ML_AI_training/test_data/pnca_merged_df2.csv at de05652ef66f3ca287be1af7f12b98d280c3d124

Tanushree Tunstall 04e0267dd1 added my_data4 after outputting merged_df3 for pnca to test the ml models

2022-03-03 13:35:05 +00:00

4.6 MiB

Raw Blame History

1	mutationinformation	lineage_labels	ligand_id	wild_type	wild_pos	position	mutant_type	pyrazinamide	drtype	mutation_info_labels	wt_prop_water	mut_prop_water	wt_prop_polarity	mut_prop_polarity	wt_calcprop	mut_calcprop	ligand_distance	ligand_affinity_change	duet_stability_change	ddg_foldx	deepddg	ddg_dynamut2	snap2_score	snap2_accuracy_pc	consurf_score	consurf_colour	consurf_colour_rev	asa	rsa	ss_class	kd_values	rd_values	af	or_mychisq	or_logistic	or_fisher	est_chisq	contacts	electro_rr	electro_sm	electro_ss	hbonds_rr	hbonds_mm	hbonds_sm	hbonds_ss	vdwclashes_rr	vdwclashes_mm	vdwclashes_sm	vdwclashes_ss	volumetric_rr	volumetric_sm	volumetric_ss	affinity_scaled	duet_scaled	foldx_scaled	deepddg_scaled	ddg_dynamut2_scaled	snap2_scaled	consurf_scaled	ligand_outcome	duet_outcome	foldx_outcome	deepddg_outcome	ddg_dynamut2_outcome	snap2_outcome	consurf_ci_upper	consurf_ci_lower	consurf_ci_colour	consurf_msa_data	consurf_aa_variety	beta_logistic	pval_logistic	se_logistic	zval_logistic	ci_low_logistic	ci_hi_logistic	log10_or_mychisq	pval_fisher	neglog_pval_fisher	ci_low_fisher	ci_hi_fisher	pval_chisq	lineage	mutation_info	mut_3upper	id	sample	sublineage	country_code	geographic_source	mutation	chain	ss	wt_3upper	wild_chain_pos	pdb_file
2	M1I	L4	PZA	M	M1	1	I	NA	Pre-XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	23.978	-0.294	-0.347	-0.0549615	-0.407	-0.79	7	53	-1.048	9	9	88	0.392857142857143	loop	0.633333333333333	4.12	0.0001437401178668	1.2119588062211	4.59700131334276e-05	0	1.01056822389159e-25	6	0	0	0	0	0	0	0	-3	0	-3	-3	0	0	0	-0.0744680851063829	-0.0896640826873385	-0.0105670806736907	-0.0693947144075021	-0.206806282722513	0.0736842105263158	-0.86326194398682	Destabilising	Destabilising	Stabilising	Destabilising	Destabilising	effect	-1.178	-0.993	9:9	21/150	V:M	-9.98752126245056	0.942832958100734	139.277183325397	-0.0717096729269464	NA	144471.706314837	0.0834878586628579	1	0	0	25.8386585962163	0.999999999999746	lineage4	other_mutations_pyrazinamide	ILE	SAMN07236323,SRR5709866	SRR5709866	lineage4.4.2	th	Thailand	pnca_p.met1ile	A	-	MET	MA1	pnca_complex.pdb
3	M1I	L2	PZA	M	M1	1	I	0	MDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	23.978	-0.294	-0.347	-0.0549615	-0.407	-0.79	7	53	-1.048	9	9	88	0.392857142857143	loop	0.633333333333333	4.12	0.0001437401178668	1.2119588062211	4.59700131334276e-05	0	1.01056822389159e-25	6	0	0	0	0	0	0	0	-3	0	-3	-3	0	0	0	-0.0744680851063829	-0.0896640826873385	-0.0105670806736907	-0.0693947144075021	-0.206806282722513	0.0736842105263158	-0.86326194398682	Destabilising	Destabilising	Stabilising	Destabilising	Destabilising	effect	-1.178	-0.993	9:9	21/150	V:M	-9.98752126245056	0.942832958100734	139.277183325397	-0.0717096729269464	NA	144471.706314837	0.0834878586628579	1	0	0	25.8386585962163	0.999999999999746	lineage2	other_mutations_pyrazinamide	ILE	SAMEA2533466,ERS456868	ERR550784_ERR550785	lineage2.2.1	uz	Nukus	pnca_p.met1ile	A	-	MET	MA1	pnca_complex.pdb
4	M1I	L2	PZA	M	M1	1	I	0	MDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	23.978	-0.294	-0.347	-0.0549615	-0.407	-0.79	7	53	-1.048	9	9	88	0.392857142857143	loop	0.633333333333333	4.12	0.0001437401178668	1.2119588062211	4.59700131334276e-05	0	1.01056822389159e-25	6	0	0	0	0	0	0	0	-3	0	-3	-3	0	0	0	-0.0744680851063829	-0.0896640826873385	-0.0105670806736907	-0.0693947144075021	-0.206806282722513	0.0736842105263158	-0.86326194398682	Destabilising	Destabilising	Stabilising	Destabilising	Destabilising	effect	-1.178	-0.993	9:9	21/150	V:M	-9.98752126245056	0.942832958100734	139.277183325397	-0.0717096729269464	NA	144471.706314837	0.0834878586628579	1	0	0	25.8386585962163	0.999999999999746	lineage2	other_mutations_pyrazinamide	ILE	ERS456961,SAMEA2533559	ERR550914_ERR550915	lineage2.2.1	uz	Nukus	pnca_p.met1ile	A	-	MET	MA1	pnca_complex.pdb
5	M1K	L3	PZA	M	M1	1	K	0	MDR	OM	hydrophobic	hydrophobic	non-polar	basic	non-polar	pos	23.978	0.215	0.296	0.0794895	-1.017	-0.34	70	85	-1.048	9	9	88	0.392857142857143	loop	0.633333333333333	4.12	7.18700589334483e-05	2.42412778478352	0.0001249735077034	0	1.03410070803344e-29	-6	-2	0	-18	0	0	0	-2	-1	0	-1	-1	0	0	0	0.0964125560538116	0.251700680272109	0.00289518061757443	-0.173401534526854	-0.0890052356020942	0.736842105263158	-0.86326194398682	Stabilising	Stabilising	Destabilising	Destabilising	Destabilising	effect	-1.178	-0.993	9:9	21/150	V:M	-8.98740878149642	0.940032862253633	119.468044435492	-0.0752285585987748	NA	4692673.51081395	0.384555509373631	1	0	0	188.544222231268	0.999999999999997	lineage3	other_mutations_pyrazinamide	LYS	ERR2510542	ERR2510542	lineage3	pk	Pakistan	pnca_p.met1lys	A	-	MET	MA1	pnca_complex.pdb
6	M1R	L2	PZA	M	M1	1	R	NA	MDR	OM	hydrophobic	hydrophilic	non-polar	basic	non-polar	pos	23.978	-0.16	0.694	-0.00977971	-0.78	1.21	44	71	-1.048	9	9	88	0.392857142857143	loop	0.633333333333333	4.12	NA	NA	NA	NA	NA	-14	0	0	-20	-2	0	-2	0	1	0	-1	1	0	-2	-2	-0.0405268490374873	0.590136054421769	-0.00188027955087288	-0.132992327365729	0.679775280898876	0.463157894736842	-0.86326194398682	Destabilising	Stabilising	Stabilising	Destabilising	Stabilising	effect	-1.178	-0.993	9:9	21/150	V:M	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	lineage2	other_mutations_pyrazinamide	ARG	SRR5073787	SRR5073787	lineage2.2.1	vn	Vietnam	pnca_p.met1arg	A	-	MET	MA1	pnca_complex.pdb
7	M1R	L4	PZA	M	M1	1	R	NA	MDR	OM	hydrophobic	hydrophilic	non-polar	basic	non-polar	pos	23.978	-0.16	0.694	-0.00977971	-0.78	1.21	44	71	-1.048	9	9	88	0.392857142857143	loop	0.633333333333333	4.12	NA	NA	NA	NA	NA	-14	0	0	-20	-2	0	-2	0	1	0	-1	1	0	-2	-2	-0.0405268490374873	0.590136054421769	-0.00188027955087288	-0.132992327365729	0.679775280898876	0.463157894736842	-0.86326194398682	Destabilising	Stabilising	Stabilising	Destabilising	Stabilising	effect	-1.178	-0.993	9:9	21/150	V:M	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	lineage4	other_mutations_pyrazinamide	ARG	ERR2707157	ERR2707157	lineage4.3.2	cd	Democratic Republic of Congo	pnca_p.met1arg	A	-	MET	MA1	pnca_complex.pdb
8	M1T	L4	PZA	M	M1	1	T	NA	MDR	DM	hydrophobic	hydrophobic	non-polar	neutral	non-polar	polar	23.978	0.344	0.109	0.867771	-1.096	0.51	52	75	-1.048	9	9	88	0.392857142857143	loop	0.633333333333333	4.12	0.0007187005893344	97.3828619670747	1395803.74890195	Inf	42.8452490786805	10	0	0	0	0	0	0	0	2	0	0	2	0	0	0	0.154260089686099	0.0926870748299319	0.031606108727482	-0.186871270247229	0.286516853932584	0.547368421052632	-0.86326194398682	Stabilising	Stabilising	Destabilising	Destabilising	Stabilising	effect	-1.178	-0.993	9:9	21/150	V:M	14.1489809714062	0.890414731995374	102.692976014008	0.137779442378573	507.712885368923	NA	1.98848253379833	2.1018584548314e-08	7.67739653395739	10.9022485555592	Inf	5.92457926729285e-11	lineage4	dr_mutations_pyrazinamide	THR	ERR2515926	ERR2515926	lineage4.8	za	South Africa	pnca_p.met1thr	A	-	MET	MA1	pnca_complex.pdb
9	M1T	L2	PZA	M	M1	1	T	1	Pre-XDR	DM	hydrophobic	hydrophobic	non-polar	neutral	non-polar	polar	23.978	0.344	0.109	0.867771	-1.096	0.51	52	75	-1.048	9	9	88	0.392857142857143	loop	0.633333333333333	4.12	0.0007187005893344	97.3828619670747	1395803.74890195	Inf	42.8452490786805	10	0	0	0	0	0	0	0	2	0	0	2	0	0	0	0.154260089686099	0.0926870748299319	0.031606108727482	-0.186871270247229	0.286516853932584	0.547368421052632	-0.86326194398682	Stabilising	Stabilising	Destabilising	Destabilising	Stabilising	effect	-1.178	-0.993	9:9	21/150	V:M	14.1489809714062	0.890414731995374	102.692976014008	0.137779442378573	507.712885368923	NA	1.98848253379833	2.1018584548314e-08	7.67739653395739	10.9022485555592	Inf	5.92457926729285e-11	lineage2	dr_mutations_pyrazinamide	THR	MDR_4152	SRR6824577	lineage2.2.1	cn	China: Pingding County, Yangquan City, Shanxi Province	pnca_p.met1thr	A	-	MET	MA1	pnca_complex.pdb
10	M1T	L2	PZA	M	M1	1	T	1	Pre-XDR	DM	hydrophobic	hydrophobic	non-polar	neutral	non-polar	polar	23.978	0.344	0.109	0.867771	-1.096	0.51	52	75	-1.048	9	9	88	0.392857142857143	loop	0.633333333333333	4.12	0.0007187005893344	97.3828619670747	1395803.74890195	Inf	42.8452490786805	10	0	0	0	0	0	0	0	2	0	0	2	0	0	0	0.154260089686099	0.0926870748299319	0.031606108727482	-0.186871270247229	0.286516853932584	0.547368421052632	-0.86326194398682	Stabilising	Stabilising	Destabilising	Destabilising	Stabilising	effect	-1.178	-0.993	9:9	21/150	V:M	14.1489809714062	0.890414731995374	102.692976014008	0.137779442378573	507.712885368923	NA	1.98848253379833	2.1018584548314e-08	7.67739653395739	10.9022485555592	Inf	5.92457926729285e-11	lineage2	dr_mutations_pyrazinamide	THR	MDR_4129	SRR6824467	lineage2.2.1	cn	China: Pingding County, Yangquan City, Shanxi Province	pnca_p.met1thr	A	-	MET	MA1	pnca_complex.pdb
11	M1T	L2	PZA	M	M1	1	T	NA	XDR	DM	hydrophobic	hydrophobic	non-polar	neutral	non-polar	polar	23.978	0.344	0.109	0.867771	-1.096	0.51	52	75	-1.048	9	9	88	0.392857142857143	loop	0.633333333333333	4.12	0.0007187005893344	97.3828619670747	1395803.74890195	Inf	42.8452490786805	10	0	0	0	0	0	0	0	2	0	0	2	0	0	0	0.154260089686099	0.0926870748299319	0.031606108727482	-0.186871270247229	0.286516853932584	0.547368421052632	-0.86326194398682	Stabilising	Stabilising	Destabilising	Destabilising	Stabilising	effect	-1.178	-0.993	9:9	21/150	V:M	14.1489809714062	0.890414731995374	102.692976014008	0.137779442378573	507.712885368923	NA	1.98848253379833	2.1018584548314e-08	7.67739653395739	10.9022485555592	Inf	5.92457926729285e-11	lineage2	dr_mutations_pyrazinamide	THR	SAMN02419548	SRR1183962_SRR1180936_SRR1159760_SRR1159954	lineage2.2.1	by	Belarus	pnca_p.met1thr	A	-	MET	MA1	pnca_complex.pdb
12	M1T	L4	PZA	M	M1	1	T	NA	XDR	DM	hydrophobic	hydrophobic	non-polar	neutral	non-polar	polar	23.978	0.344	0.109	0.867771	-1.096	0.51	52	75	-1.048	9	9	88	0.392857142857143	loop	0.633333333333333	4.12	0.0007187005893344	97.3828619670747	1395803.74890195	Inf	42.8452490786805	10	0	0	0	0	0	0	0	2	0	0	2	0	0	0	0.154260089686099	0.0926870748299319	0.031606108727482	-0.186871270247229	0.286516853932584	0.547368421052632	-0.86326194398682	Stabilising	Stabilising	Destabilising	Destabilising	Stabilising	effect	-1.178	-0.993	9:9	21/150	V:M	14.1489809714062	0.890414731995374	102.692976014008	0.137779442378573	507.712885368923	NA	1.98848253379833	2.1018584548314e-08	7.67739653395739	10.9022485555592	Inf	5.92457926729285e-11	lineage4	dr_mutations_pyrazinamide	THR	ERR1034850	ERR1034850	lineage4.3.4.2	pt	Portugal	pnca_p.met1thr	A	-	MET	MA1	pnca_complex.pdb
13	M1T	L4	PZA	M	M1	1	T	NA	XDR	DM	hydrophobic	hydrophobic	non-polar	neutral	non-polar	polar	23.978	0.344	0.109	0.867771	-1.096	0.51	52	75	-1.048	9	9	88	0.392857142857143	loop	0.633333333333333	4.12	0.0007187005893344	97.3828619670747	1395803.74890195	Inf	42.8452490786805	10	0	0	0	0	0	0	0	2	0	0	2	0	0	0	0.154260089686099	0.0926870748299319	0.031606108727482	-0.186871270247229	0.286516853932584	0.547368421052632	-0.86326194398682	Stabilising	Stabilising	Destabilising	Destabilising	Stabilising	effect	-1.178	-0.993	9:9	21/150	V:M	14.1489809714062	0.890414731995374	102.692976014008	0.137779442378573	507.712885368923	NA	1.98848253379833	2.1018584548314e-08	7.67739653395739	10.9022485555592	Inf	5.92457926729285e-11	lineage4	dr_mutations_pyrazinamide	THR	ERR275203	ERR275203	lineage4.3.4.2	pt	Portugal	pnca_p.met1thr	A	-	MET	MA1	pnca_complex.pdb
14	M1T	L4	PZA	M	M1	1	T	NA	XDR	DM	hydrophobic	hydrophobic	non-polar	neutral	non-polar	polar	23.978	0.344	0.109	0.867771	-1.096	0.51	52	75	-1.048	9	9	88	0.392857142857143	loop	0.633333333333333	4.12	0.0007187005893344	97.3828619670747	1395803.74890195	Inf	42.8452490786805	10	0	0	0	0	0	0	0	2	0	0	2	0	0	0	0.154260089686099	0.0926870748299319	0.031606108727482	-0.186871270247229	0.286516853932584	0.547368421052632	-0.86326194398682	Stabilising	Stabilising	Destabilising	Destabilising	Stabilising	effect	-1.178	-0.993	9:9	21/150	V:M	14.1489809714062	0.890414731995374	102.692976014008	0.137779442378573	507.712885368923	NA	1.98848253379833	2.1018584548314e-08	7.67739653395739	10.9022485555592	Inf	5.92457926729285e-11	lineage4	dr_mutations_pyrazinamide	THR	ERR1034847	ERR1034847	lineage4.3.4.2	pt	Portugal	pnca_p.met1thr	A	-	MET	MA1	pnca_complex.pdb
15	M1T	L2	PZA	M	M1	1	T	1	Pre-XDR	DM	hydrophobic	hydrophobic	non-polar	neutral	non-polar	polar	23.978	0.344	0.109	0.867771	-1.096	0.51	52	75	-1.048	9	9	88	0.392857142857143	loop	0.633333333333333	4.12	0.0007187005893344	97.3828619670747	1395803.74890195	Inf	42.8452490786805	10	0	0	0	0	0	0	0	2	0	0	2	0	0	0	0.154260089686099	0.0926870748299319	0.031606108727482	-0.186871270247229	0.286516853932584	0.547368421052632	-0.86326194398682	Stabilising	Stabilising	Destabilising	Destabilising	Stabilising	effect	-1.178	-0.993	9:9	21/150	V:M	14.1489809714062	0.890414731995374	102.692976014008	0.137779442378573	507.712885368923	NA	1.98848253379833	2.1018584548314e-08	7.67739653395739	10.9022485555592	Inf	5.92457926729285e-11	lineage2	dr_mutations_pyrazinamide	THR	MDR_4113	SRR6824464	lineage2.2.1	cn	China: Pingding County, Yangquan City, Shanxi Province	pnca_p.met1thr	A	-	MET	MA1	pnca_complex.pdb
16	M1T	L4	PZA	M	M1	1	T	1	XDR	DM	hydrophobic	hydrophobic	non-polar	neutral	non-polar	polar	23.978	0.344	0.109	0.867771	-1.096	0.51	52	75	-1.048	9	9	88	0.392857142857143	loop	0.633333333333333	4.12	0.0007187005893344	97.3828619670747	1395803.74890195	Inf	42.8452490786805	10	0	0	0	0	0	0	0	2	0	0	2	0	0	0	0.154260089686099	0.0926870748299319	0.031606108727482	-0.186871270247229	0.286516853932584	0.547368421052632	-0.86326194398682	Stabilising	Stabilising	Destabilising	Destabilising	Stabilising	effect	-1.178	-0.993	9:9	21/150	V:M	14.1489809714062	0.890414731995374	102.692976014008	0.137779442378573	507.712885368923	NA	1.98848253379833	2.1018584548314e-08	7.67739653395739	10.9022485555592	Inf	5.92457926729285e-11	lineage4	dr_mutations_pyrazinamide	THR	ERR1034908	ERR1034908	lineage4.3.4.2	pt	Portugal	pnca_p.met1thr	A	-	MET	MA1	pnca_complex.pdb
17	M1T	L4	PZA	M	M1	1	T	1	XDR	DM	hydrophobic	hydrophobic	non-polar	neutral	non-polar	polar	23.978	0.344	0.109	0.867771	-1.096	0.51	52	75	-1.048	9	9	88	0.392857142857143	loop	0.633333333333333	4.12	0.0007187005893344	97.3828619670747	1395803.74890195	Inf	42.8452490786805	10	0	0	0	0	0	0	0	2	0	0	2	0	0	0	0.154260089686099	0.0926870748299319	0.031606108727482	-0.186871270247229	0.286516853932584	0.547368421052632	-0.86326194398682	Stabilising	Stabilising	Destabilising	Destabilising	Stabilising	effect	-1.178	-0.993	9:9	21/150	V:M	14.1489809714062	0.890414731995374	102.692976014008	0.137779442378573	507.712885368923	NA	1.98848253379833	2.1018584548314e-08	7.67739653395739	10.9022485555592	Inf	5.92457926729285e-11	lineage4	dr_mutations_pyrazinamide	THR	ERR2864241	ERR2864241	lineage4.3.4.2	pt	Portugal	pnca_p.met1thr	A	-	MET	MA1	pnca_complex.pdb
18	M1T	L4	PZA	M	M1	1	T	1	XDR	DM	hydrophobic	hydrophobic	non-polar	neutral	non-polar	polar	23.978	0.344	0.109	0.867771	-1.096	0.51	52	75	-1.048	9	9	88	0.392857142857143	loop	0.633333333333333	4.12	0.0007187005893344	97.3828619670747	1395803.74890195	Inf	42.8452490786805	10	0	0	0	0	0	0	0	2	0	0	2	0	0	0	0.154260089686099	0.0926870748299319	0.031606108727482	-0.186871270247229	0.286516853932584	0.547368421052632	-0.86326194398682	Stabilising	Stabilising	Destabilising	Destabilising	Stabilising	effect	-1.178	-0.993	9:9	21/150	V:M	14.1489809714062	0.890414731995374	102.692976014008	0.137779442378573	507.712885368923	NA	1.98848253379833	2.1018584548314e-08	7.67739653395739	10.9022485555592	Inf	5.92457926729285e-11	lineage4	dr_mutations_pyrazinamide	THR	ERR1035222	ERR1035222	lineage4.3.4.2	pt	Portugal	pnca_p.met1thr	A	-	MET	MA1	pnca_complex.pdb
19	M1T	L1	PZA	M	M1	1	T	NA	Pre-XDR	DM	hydrophobic	hydrophobic	non-polar	neutral	non-polar	polar	23.978	0.344	0.109	0.867771	-1.096	0.51	52	75	-1.048	9	9	88	0.392857142857143	loop	0.633333333333333	4.12	0.0007187005893344	97.3828619670747	1395803.74890195	Inf	42.8452490786805	10	0	0	0	0	0	0	0	2	0	0	2	0	0	0	0.154260089686099	0.0926870748299319	0.031606108727482	-0.186871270247229	0.286516853932584	0.547368421052632	-0.86326194398682	Stabilising	Stabilising	Destabilising	Destabilising	Stabilising	effect	-1.178	-0.993	9:9	21/150	V:M	14.1489809714062	0.890414731995374	102.692976014008	0.137779442378573	507.712885368923	NA	1.98848253379833	2.1018584548314e-08	7.67739653395739	10.9022485555592	Inf	5.92457926729285e-11	lineage1	dr_mutations_pyrazinamide	THR	SRR5818699	SRR5818699	lineage1.1.2	dj	Djibouti	pnca_p.met1thr	A	-	MET	MA1	pnca_complex.pdb
20	M1T	L2	PZA	M	M1	1	T	NA	Pre-XDR	DM	hydrophobic	hydrophobic	non-polar	neutral	non-polar	polar	23.978	0.344	0.109	0.867771	-1.096	0.51	52	75	-1.048	9	9	88	0.392857142857143	loop	0.633333333333333	4.12	0.0007187005893344	97.3828619670747	1395803.74890195	Inf	42.8452490786805	10	0	0	0	0	0	0	0	2	0	0	2	0	0	0	0.154260089686099	0.0926870748299319	0.031606108727482	-0.186871270247229	0.286516853932584	0.547368421052632	-0.86326194398682	Stabilising	Stabilising	Destabilising	Destabilising	Stabilising	effect	-1.178	-0.993	9:9	21/150	V:M	14.1489809714062	0.890414731995374	102.692976014008	0.137779442378573	507.712885368923	NA	1.98848253379833	2.1018584548314e-08	7.67739653395739	10.9022485555592	Inf	5.92457926729285e-11	lineage2	dr_mutations_pyrazinamide	THR	SRS797056	SRR1723559	lineage2.2.1	cn	China:Shanxi	pnca_p.met1thr	A	-	MET	MA1	pnca_complex.pdb
21	M1T	L4	PZA	M	M1	1	T	1	XDR	DM	hydrophobic	hydrophobic	non-polar	neutral	non-polar	polar	23.978	0.344	0.109	0.867771	-1.096	0.51	52	75	-1.048	9	9	88	0.392857142857143	loop	0.633333333333333	4.12	0.0007187005893344	97.3828619670747	1395803.74890195	Inf	42.8452490786805	10	0	0	0	0	0	0	0	2	0	0	2	0	0	0	0.154260089686099	0.0926870748299319	0.031606108727482	-0.186871270247229	0.286516853932584	0.547368421052632	-0.86326194398682	Stabilising	Stabilising	Destabilising	Destabilising	Stabilising	effect	-1.178	-0.993	9:9	21/150	V:M	14.1489809714062	0.890414731995374	102.692976014008	0.137779442378573	507.712885368923	NA	1.98848253379833	2.1018584548314e-08	7.67739653395739	10.9022485555592	Inf	5.92457926729285e-11	lineage4	dr_mutations_pyrazinamide	THR	ERR1035226	ERR1035226	lineage4.3.4.2	pt	Portugal	pnca_p.met1thr	A	-	MET	MA1	pnca_complex.pdb
22	M1T	L2	PZA	M	M1	1	T	NA	Pre-XDR	DM	hydrophobic	hydrophobic	non-polar	neutral	non-polar	polar	23.978	0.344	0.109	0.867771	-1.096	0.51	52	75	-1.048	9	9	88	0.392857142857143	loop	0.633333333333333	4.12	0.0007187005893344	97.3828619670747	1395803.74890195	Inf	42.8452490786805	10	0	0	0	0	0	0	0	2	0	0	2	0	0	0	0.154260089686099	0.0926870748299319	0.031606108727482	-0.186871270247229	0.286516853932584	0.547368421052632	-0.86326194398682	Stabilising	Stabilising	Destabilising	Destabilising	Stabilising	effect	-1.178	-0.993	9:9	21/150	V:M	14.1489809714062	0.890414731995374	102.692976014008	0.137779442378573	507.712885368923	NA	1.98848253379833	2.1018584548314e-08	7.67739653395739	10.9022485555592	Inf	5.92457926729285e-11	lineage2	dr_mutations_pyrazinamide	THR	SRR5709907,SAMN07236409	SRR5709907	lineage2.2.1	th	Thailand	pnca_p.met1thr	A	-	MET	MA1	pnca_complex.pdb
23	M1T	L2	PZA	M	M1	1	T	NA	Pre-XDR	DM	hydrophobic	hydrophobic	non-polar	neutral	non-polar	polar	23.978	0.344	0.109	0.867771	-1.096	0.51	52	75	-1.048	9	9	88	0.392857142857143	loop	0.633333333333333	4.12	0.0007187005893344	97.3828619670747	1395803.74890195	Inf	42.8452490786805	10	0	0	0	0	0	0	0	2	0	0	2	0	0	0	0.154260089686099	0.0926870748299319	0.031606108727482	-0.186871270247229	0.286516853932584	0.547368421052632	-0.86326194398682	Stabilising	Stabilising	Destabilising	Destabilising	Stabilising	effect	-1.178	-0.993	9:9	21/150	V:M	14.1489809714062	0.890414731995374	102.692976014008	0.137779442378573	507.712885368923	NA	1.98848253379833	2.1018584548314e-08	7.67739653395739	10.9022485555592	Inf	5.92457926729285e-11	lineage2	dr_mutations_pyrazinamide	THR	SRS797053	SRR1723556	lineage2.2.1	cn	China:Shanxi	pnca_p.met1thr	A	-	MET	MA1	pnca_complex.pdb
24	M1T	L3	PZA	M	M1	1	T	1	Pre-XDR	DM	hydrophobic	hydrophobic	non-polar	neutral	non-polar	polar	23.978	0.344	0.109	0.867771	-1.096	0.51	52	75	-1.048	9	9	88	0.392857142857143	loop	0.633333333333333	4.12	0.0007187005893344	97.3828619670747	1395803.74890195	Inf	42.8452490786805	10	0	0	0	0	0	0	0	2	0	0	2	0	0	0	0.154260089686099	0.0926870748299319	0.031606108727482	-0.186871270247229	0.286516853932584	0.547368421052632	-0.86326194398682	Stabilising	Stabilising	Destabilising	Destabilising	Stabilising	effect	-1.178	-0.993	9:9	21/150	V:M	14.1489809714062	0.890414731995374	102.692976014008	0.137779442378573	507.712885368923	NA	1.98848253379833	2.1018584548314e-08	7.67739653395739	10.9022485555592	Inf	5.92457926729285e-11	lineage3	dr_mutations_pyrazinamide	THR	ERR2510282	ERR2510282	lineage3	pk	Pakistan	pnca_p.met1thr	A	-	MET	MA1	pnca_complex.pdb
25	M1T	L2	PZA	M	M1	1	T	NA	XDR	DM	hydrophobic	hydrophobic	non-polar	neutral	non-polar	polar	23.978	0.344	0.109	0.867771	-1.096	0.51	52	75	-1.048	9	9	88	0.392857142857143	loop	0.633333333333333	4.12	0.0007187005893344	97.3828619670747	1395803.74890195	Inf	42.8452490786805	10	0	0	0	0	0	0	0	2	0	0	2	0	0	0	0.154260089686099	0.0926870748299319	0.031606108727482	-0.186871270247229	0.286516853932584	0.547368421052632	-0.86326194398682	Stabilising	Stabilising	Destabilising	Destabilising	Stabilising	effect	-1.178	-0.993	9:9	21/150	V:M	14.1489809714062	0.890414731995374	102.692976014008	0.137779442378573	507.712885368923	NA	1.98848253379833	2.1018584548314e-08	7.67739653395739	10.9022485555592	Inf	5.92457926729285e-11	lineage2	dr_mutations_pyrazinamide	THR	SAMN02419662	SRR1172219_SRR1169121_SRR1163325_SRR1163145	lineage2.2.1	by	Belarus	pnca_p.met1thr	A	-	MET	MA1	pnca_complex.pdb
26	M1T	L2	PZA	M	M1	1	T	NA	MDR	DM	hydrophobic	hydrophobic	non-polar	neutral	non-polar	polar	23.978	0.344	0.109	0.867771	-1.096	0.51	52	75	-1.048	9	9	88	0.392857142857143	loop	0.633333333333333	4.12	0.0007187005893344	97.3828619670747	1395803.74890195	Inf	42.8452490786805	10	0	0	0	0	0	0	0	2	0	0	2	0	0	0	0.154260089686099	0.0926870748299319	0.031606108727482	-0.186871270247229	0.286516853932584	0.547368421052632	-0.86326194398682	Stabilising	Stabilising	Destabilising	Destabilising	Stabilising	effect	-1.178	-0.993	9:9	21/150	V:M	14.1489809714062	0.890414731995374	102.692976014008	0.137779442378573	507.712885368923	NA	1.98848253379833	2.1018584548314e-08	7.67739653395739	10.9022485555592	Inf	5.92457926729285e-11	lineage2	dr_mutations_pyrazinamide	THR	ETB0073	SRR6257010	lineage2.2.1	ru	Russia:Tatarstan	pnca_p.met1thr	A	-	MET	MA1	pnca_complex.pdb
27	M1T	L4	PZA	M	M1	1	T	NA	XDR	DM	hydrophobic	hydrophobic	non-polar	neutral	non-polar	polar	23.978	0.344	0.109	0.867771	-1.096	0.51	52	75	-1.048	9	9	88	0.392857142857143	loop	0.633333333333333	4.12	0.0007187005893344	97.3828619670747	1395803.74890195	Inf	42.8452490786805	10	0	0	0	0	0	0	0	2	0	0	2	0	0	0	0.154260089686099	0.0926870748299319	0.031606108727482	-0.186871270247229	0.286516853932584	0.547368421052632	-0.86326194398682	Stabilising	Stabilising	Destabilising	Destabilising	Stabilising	effect	-1.178	-0.993	9:9	21/150	V:M	14.1489809714062	0.890414731995374	102.692976014008	0.137779442378573	507.712885368923	NA	1.98848253379833	2.1018584548314e-08	7.67739653395739	10.9022485555592	Inf	5.92457926729285e-11	lineage4	dr_mutations_pyrazinamide	THR	ERR1034885	ERR1034885	lineage4.3.4.2	pt	Portugal	pnca_p.met1thr	A	-	MET	MA1	pnca_complex.pdb
28	M1T	L2	PZA	M	M1	1	T	1	Pre-XDR	DM	hydrophobic	hydrophobic	non-polar	neutral	non-polar	polar	23.978	0.344	0.109	0.867771	-1.096	0.51	52	75	-1.048	9	9	88	0.392857142857143	loop	0.633333333333333	4.12	0.0007187005893344	97.3828619670747	1395803.74890195	Inf	42.8452490786805	10	0	0	0	0	0	0	0	2	0	0	2	0	0	0	0.154260089686099	0.0926870748299319	0.031606108727482	-0.186871270247229	0.286516853932584	0.547368421052632	-0.86326194398682	Stabilising	Stabilising	Destabilising	Destabilising	Stabilising	effect	-1.178	-0.993	9:9	21/150	V:M	14.1489809714062	0.890414731995374	102.692976014008	0.137779442378573	507.712885368923	NA	1.98848253379833	2.1018584548314e-08	7.67739653395739	10.9022485555592	Inf	5.92457926729285e-11	lineage2	dr_mutations_pyrazinamide	THR	ERR2510666	ERR2510666	lineage2.2.1	it	Italy	pnca_p.met1thr	A	-	MET	MA1	pnca_complex.pdb
29	M1T	L4	PZA	M	M1	1	T	1	XDR	DM	hydrophobic	hydrophobic	non-polar	neutral	non-polar	polar	23.978	0.344	0.109	0.867771	-1.096	0.51	52	75	-1.048	9	9	88	0.392857142857143	loop	0.633333333333333	4.12	0.0007187005893344	97.3828619670747	1395803.74890195	Inf	42.8452490786805	10	0	0	0	0	0	0	0	2	0	0	2	0	0	0	0.154260089686099	0.0926870748299319	0.031606108727482	-0.186871270247229	0.286516853932584	0.547368421052632	-0.86326194398682	Stabilising	Stabilising	Destabilising	Destabilising	Stabilising	effect	-1.178	-0.993	9:9	21/150	V:M	14.1489809714062	0.890414731995374	102.692976014008	0.137779442378573	507.712885368923	NA	1.98848253379833	2.1018584548314e-08	7.67739653395739	10.9022485555592	Inf	5.92457926729285e-11	lineage4	dr_mutations_pyrazinamide	THR	ERR1035215	ERR1035215	lineage4.3.4.2	pt	Portugal	pnca_p.met1thr	A	-	MET	MA1	pnca_complex.pdb
30	M1T	L2	PZA	M	M1	1	T	NA	Pre-XDR	DM	hydrophobic	hydrophobic	non-polar	neutral	non-polar	polar	23.978	0.344	0.109	0.867771	-1.096	0.51	52	75	-1.048	9	9	88	0.392857142857143	loop	0.633333333333333	4.12	0.0007187005893344	97.3828619670747	1395803.74890195	Inf	42.8452490786805	10	0	0	0	0	0	0	0	2	0	0	2	0	0	0	0.154260089686099	0.0926870748299319	0.031606108727482	-0.186871270247229	0.286516853932584	0.547368421052632	-0.86326194398682	Stabilising	Stabilising	Destabilising	Destabilising	Stabilising	effect	-1.178	-0.993	9:9	21/150	V:M	14.1489809714062	0.890414731995374	102.692976014008	0.137779442378573	507.712885368923	NA	1.98848253379833	2.1018584548314e-08	7.67739653395739	10.9022485555592	Inf	5.92457926729285e-11	lineage2	dr_mutations_pyrazinamide	THR	SRR5710022,SAMN07236279	SRR5710022	lineage2.1	th	Thailand	pnca_p.met1thr	A	-	MET	MA1	pnca_complex.pdb
31	M1T	L2	PZA	M	M1	1	T	NA	Pre-XDR	DM	hydrophobic	hydrophobic	non-polar	neutral	non-polar	polar	23.978	0.344	0.109	0.867771	-1.096	0.51	52	75	-1.048	9	9	88	0.392857142857143	loop	0.633333333333333	4.12	0.0007187005893344	97.3828619670747	1395803.74890195	Inf	42.8452490786805	10	0	0	0	0	0	0	0	2	0	0	2	0	0	0	0.154260089686099	0.0926870748299319	0.031606108727482	-0.186871270247229	0.286516853932584	0.547368421052632	-0.86326194398682	Stabilising	Stabilising	Destabilising	Destabilising	Stabilising	effect	-1.178	-0.993	9:9	21/150	V:M	14.1489809714062	0.890414731995374	102.692976014008	0.137779442378573	507.712885368923	NA	1.98848253379833	2.1018584548314e-08	7.67739653395739	10.9022485555592	Inf	5.92457926729285e-11	lineage2	dr_mutations_pyrazinamide	THR	SRS797054	SRR1723557	lineage2.2.1	cn	China:Shanxi	pnca_p.met1thr	A	-	MET	MA1	pnca_complex.pdb
32	M1T	L2	PZA	M	M1	1	T	NA	Pre-XDR	DM	hydrophobic	hydrophobic	non-polar	neutral	non-polar	polar	23.978	0.344	0.109	0.867771	-1.096	0.51	52	75	-1.048	9	9	88	0.392857142857143	loop	0.633333333333333	4.12	0.0007187005893344	97.3828619670747	1395803.74890195	Inf	42.8452490786805	10	0	0	0	0	0	0	0	2	0	0	2	0	0	0	0.154260089686099	0.0926870748299319	0.031606108727482	-0.186871270247229	0.286516853932584	0.547368421052632	-0.86326194398682	Stabilising	Stabilising	Destabilising	Destabilising	Stabilising	effect	-1.178	-0.993	9:9	21/150	V:M	14.1489809714062	0.890414731995374	102.692976014008	0.137779442378573	507.712885368923	NA	1.98848253379833	2.1018584548314e-08	7.67739653395739	10.9022485555592	Inf	5.92457926729285e-11	lineage2	dr_mutations_pyrazinamide	THR	SRS797055	SRR1723558	lineage2.2.1	cn	China:Shanxi	pnca_p.met1thr	A	-	MET	MA1	pnca_complex.pdb
33	M1T	L4	PZA	M	M1	1	T	NA	XDR	DM	hydrophobic	hydrophobic	non-polar	neutral	non-polar	polar	23.978	0.344	0.109	0.867771	-1.096	0.51	52	75	-1.048	9	9	88	0.392857142857143	loop	0.633333333333333	4.12	0.0007187005893344	97.3828619670747	1395803.74890195	Inf	42.8452490786805	10	0	0	0	0	0	0	0	2	0	0	2	0	0	0	0.154260089686099	0.0926870748299319	0.031606108727482	-0.186871270247229	0.286516853932584	0.547368421052632	-0.86326194398682	Stabilising	Stabilising	Destabilising	Destabilising	Stabilising	effect	-1.178	-0.993	9:9	21/150	V:M	14.1489809714062	0.890414731995374	102.692976014008	0.137779442378573	507.712885368923	NA	1.98848253379833	2.1018584548314e-08	7.67739653395739	10.9022485555592	Inf	5.92457926729285e-11	lineage4	dr_mutations_pyrazinamide	THR	ERR275230	ERR275230	lineage4.3.4.2	pt	Portugal	pnca_p.met1thr	A	-	MET	MA1	pnca_complex.pdb
34	R2L	L4	PZA	R	R2	2	L	0	Pre-XDR	OM	hydrophilic	hydrophobic	basic	non-polar	pos	non-polar	21.092	-2.083	0.062	1.78755	-0.708	-0.24	44	71	-0.015	5	5	55	0.200729927007299	strand	-0.266666666666667	4.74	7.18700589334483e-05	2.42412778478352	0.0001249735077034	0	1.03410070803344e-29	38	30	4	26	4	0	2	2	1	0	-2	2	0	0	-2	-0.527608915906788	0.0527210884353741	0.0651064620225963	-0.120716112531969	-0.06282722513089	0.463157894736842	-0.0123558484349259	Destabilising	Stabilising	Destabilising	Destabilising	Destabilising	effect	-0.244	0.083	6:5	84/150	R:K:N:H:T:S:E	-8.9874087814964	0.940032862253633	119.46804443549	-0.0752285585987755	NA	4692673.51081259	0.384555509373631	1	0	0	188.544222231268	0.999999999999997	lineage4	other_mutations_pyrazinamide	LEU	ERR2516706	ERR2516706	lineage4	pe	Peru	pnca_p.arg2leu	A	E	ARG	RA2	pnca_complex.pdb
35	R2P	L4	PZA	R	R2	2	P	NA	MDR	OM	hydrophilic	hydrophilic	basic	non-polar	pos	non-polar	21.092	-2.244	-1.031	4.20376	-1.935	-0.43	63	80	-0.015	5	5	55	0.200729927007299	strand	-0.266666666666667	4.74	NA	NA	NA	NA	NA	48	28	4	24	2	0	4	0	4	2	1	1	4	6	0	-0.56838905775076	-0.26640826873385	0.153110089671399	-0.329923273657289	-0.112565445026178	0.663157894736842	-0.0123558484349259	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.244	0.083	6:5	84/150	R:K:N:H:T:S:E	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	lineage4	other_mutations_pyrazinamide	PRO	ERR779907	ERR779907	lineage4.3.3	pe		pnca_p.arg2pro	A	E	ARG	RA2	pnca_complex.pdb
36	R2W	L4	PZA	R	R2	2	W	NA	Pre-XDR	OM	hydrophilic	hydrophobic	basic	non-polar	pos	non-polar	21.092	-1.147	-0.164	4.38565	-0.74	-0.16	58	75	-0.015	5	5	55	0.200729927007299	strand	-0.266666666666667	4.74	NA	NA	NA	NA	NA	8	30	4	26	4	0	2	2	0	0	-5	5	6	6	4	-0.290526849037487	-0.0423772609819121	0.159734919397723	-0.12617220801364	-0.0418848167539267	0.610526315789474	-0.0123558484349259	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.244	0.083	6:5	84/150	R:K:N:H:T:S:E	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	lineage4	other_mutations_pyrazinamide	TRP	SAMN02584674	SRR1168960_SRR1166135	lineage4.2.1	md	Moldova	pnca_p.arg2trp	A	E	ARG	RA2	pnca_complex.pdb
37	A3E	L2	PZA	A	A3	3	E	1	MDR	DM	hydrophobic	hydrophilic	non-polar	acidic	non-polar	neg	18.028	-1.552	-2.829	2.75936	-5.34	-1.11	56	75	-0.873	8	8	0	0	strand	0.366666666666667	8.38	0.0002874802357337	38.8547368421053	1392277.50785087	Inf	13.9909822352959	-30	-38	-2	-36	0	0	0	0	-13	0	-3	-14	-4	-2	-9	-0.393110435663627	-0.731007751937984	0.100501897595408	-0.910485933503836	-0.290575916230366	0.589473684210526	-0.719110378912685	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.993	-0.827	9:8	141/150	A:G:T:V:C	14.1464514590954	0.930573112990226	162.371849599086	0.0871237932808215	0.011399544335555	NA	1.58944397188817	0.0008528275207519	3.06913879340442	3.20302487654751	Inf	0.0001836895199759	lineage2	dr_mutations_pyrazinamide	GLU	MDR_17174	SRR6824459	lineage2.2.1	cn	China: Ma City, Huanggang City,Hubei Province	pnca_p.ala3glu	A	E	ALA	AA3	pnca_complex.pdb
38	A3E	L2	PZA	A	A3	3	E	NA	MDR	DM	hydrophobic	hydrophilic	non-polar	acidic	non-polar	neg	18.028	-1.552	-2.829	2.75936	-5.34	-1.11	56	75	-0.873	8	8	0	0	strand	0.366666666666667	8.38	0.0002874802357337	38.8547368421053	1392277.50785087	Inf	13.9909822352959	-30	-38	-2	-36	0	0	0	0	-13	0	-3	-14	-4	-2	-9	-0.393110435663627	-0.731007751937984	0.100501897595408	-0.910485933503836	-0.290575916230366	0.589473684210526	-0.719110378912685	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.993	-0.827	9:8	141/150	A:G:T:V:C	14.1464514590954	0.930573112990226	162.371849599086	0.0871237932808215	0.011399544335555	NA	1.58944397188817	0.0008528275207519	3.06913879340442	3.20302487654751	Inf	0.0001836895199759	lineage2	dr_mutations_pyrazinamide	GLU	SRS797278	SRR1723804	lineage2.2.1	cn	China:Hubei	pnca_p.ala3glu	A	E	ALA	AA3	pnca_complex.pdb
39	A3E	L6	PZA	A	A3	3	E	NA	MDR	DM	hydrophobic	hydrophilic	non-polar	acidic	non-polar	neg	18.028	-1.552	-2.829	2.75936	-5.34	-1.11	56	75	-0.873	8	8	0	0	strand	0.366666666666667	8.38	0.0002874802357337	38.8547368421053	1392277.50785087	Inf	13.9909822352959	-30	-38	-2	-36	0	0	0	0	-13	0	-3	-14	-4	-2	-9	-0.393110435663627	-0.731007751937984	0.100501897595408	-0.910485933503836	-0.290575916230366	0.589473684210526	-0.719110378912685	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.993	-0.827	9:8	141/150	A:G:T:V:C	14.1464514590954	0.930573112990226	162.371849599086	0.0871237932808215	0.011399544335555	NA	1.58944397188817	0.0008528275207519	3.06913879340442	3.20302487654751	Inf	0.0001836895199759	lineage6	dr_mutations_pyrazinamide	GLU	ERR1215461	ERR1215461	lineage6	gh	Ghana	pnca_p.ala3glu	A	E	ALA	AA3	pnca_complex.pdb
40	A3E	L2	PZA	A	A3	3	E	1	MDR	DM	hydrophobic	hydrophilic	non-polar	acidic	non-polar	neg	18.028	-1.552	-2.829	2.75936	-5.34	-1.11	56	75	-0.873	8	8	0	0	strand	0.366666666666667	8.38	0.0002874802357337	38.8547368421053	1392277.50785087	Inf	13.9909822352959	-30	-38	-2	-36	0	0	0	0	-13	0	-3	-14	-4	-2	-9	-0.393110435663627	-0.731007751937984	0.100501897595408	-0.910485933503836	-0.290575916230366	0.589473684210526	-0.719110378912685	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.993	-0.827	9:8	141/150	A:G:T:V:C	14.1464514590954	0.930573112990226	162.371849599086	0.0871237932808215	0.011399544335555	NA	1.58944397188817	0.0008528275207519	3.06913879340442	3.20302487654751	Inf	0.0001836895199759	lineage2	dr_mutations_pyrazinamide	GLU	MDR_17238	SRR6824452	lineage2.2.1	cn	China: Ma City, Huanggang City,Hubei Province	pnca_p.ala3glu	A	E	ALA	AA3	pnca_complex.pdb
41	A3E	L2	PZA	A	A3	3	E	1	XDR	DM	hydrophobic	hydrophilic	non-polar	acidic	non-polar	neg	18.028	-1.552	-2.829	2.75936	-5.34	-1.11	56	75	-0.873	8	8	0	0	strand	0.366666666666667	8.38	0.0002874802357337	38.8547368421053	1392277.50785087	Inf	13.9909822352959	-30	-38	-2	-36	0	0	0	0	-13	0	-3	-14	-4	-2	-9	-0.393110435663627	-0.731007751937984	0.100501897595408	-0.910485933503836	-0.290575916230366	0.589473684210526	-0.719110378912685	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.993	-0.827	9:8	141/150	A:G:T:V:C	14.1464514590954	0.930573112990226	162.371849599086	0.0871237932808215	0.011399544335555	NA	1.58944397188817	0.0008528275207519	3.06913879340442	3.20302487654751	Inf	0.0001836895199759	lineage2	dr_mutations_pyrazinamide	GLU	ERR067750,0450Q-sc-2011-08-25T12:38:41Z-1262349	ERR067750	lineage2.2.1	ru	Russia,Samara	pnca_p.ala3glu	A	E	ALA	AA3	pnca_complex.pdb
42	A3E	L2	PZA	A	A3	3	E	1	Pre-XDR	DM	hydrophobic	hydrophilic	non-polar	acidic	non-polar	neg	18.028	-1.552	-2.829	2.75936	-5.34	-1.11	56	75	-0.873	8	8	0	0	strand	0.366666666666667	8.38	0.0002874802357337	38.8547368421053	1392277.50785087	Inf	13.9909822352959	-30	-38	-2	-36	0	0	0	0	-13	0	-3	-14	-4	-2	-9	-0.393110435663627	-0.731007751937984	0.100501897595408	-0.910485933503836	-0.290575916230366	0.589473684210526	-0.719110378912685	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.993	-0.827	9:8	141/150	A:G:T:V:C	14.1464514590954	0.930573112990226	162.371849599086	0.0871237932808215	0.011399544335555	NA	1.58944397188817	0.0008528275207519	3.06913879340442	3.20302487654751	Inf	0.0001836895199759	lineage2	dr_mutations_pyrazinamide	GLU	ETB0012	SRR6256984	lineage2.2.1	ru	Russia:Arkhangelsk	pnca_p.ala3glu	A	E	ALA	AA3	pnca_complex.pdb
43	A3P	L4	PZA	A	A3	3	P	NA	Pre-XDR	DM	hydrophobic	hydrophilic	non-polar	non-polar	non-polar	non-polar	18.028	-2.664	-1.124	-0.155697	-3.837	-0.13	66	80	-0.873	8	8	0	0	strand	0.366666666666667	8.38	7.18700589334483e-05	9.70142977291842	188179.926264599	Inf	0.763784339928386	0	0	0	0	0	0	0	0	-7	2	-7	-4	-2	-2	-1	-0.674772036474164	-0.290439276485788	-0.0299348227332154	-0.654219948849105	-0.0340314136125654	0.694736842105263	-0.719110378912685	Destabilising	Destabilising	Stabilising	Destabilising	Destabilising	effect	-0.993	-0.827	9:8	141/150	A:G:T:V:C	12.1451538387263	0.919026337424228	119.468044436222	0.101660271548263	5.01153666063644e-06	NA	0.986835744238421	0.170978870202674	0.767057556984365	0.124324963210678	Inf	0.382146811758261	lineage4	dr_mutations_pyrazinamide	PRO	3200	ERR2432999	lineage4.1.2.1	br	Brazil	pnca_p.ala3pro	A	E	ALA	AA3	pnca_complex.pdb
44	A3P	L4	PZA	A	A3	3	P	NA	MDR	DM	hydrophobic	hydrophilic	non-polar	non-polar	non-polar	non-polar	18.028	-2.664	-1.124	-0.155697	-3.837	-0.13	66	80	-0.873	8	8	0	0	strand	0.366666666666667	8.38	7.18700589334483e-05	9.70142977291842	188179.926264599	Inf	0.763784339928386	0	0	0	0	0	0	0	0	-7	2	-7	-4	-2	-2	-1	-0.674772036474164	-0.290439276485788	-0.0299348227332154	-0.654219948849105	-0.0340314136125654	0.694736842105263	-0.719110378912685	Destabilising	Destabilising	Stabilising	Destabilising	Destabilising	effect	-0.993	-0.827	9:8	141/150	A:G:T:V:C	12.1451538387263	0.919026337424228	119.468044436222	0.101660271548263	5.01153666063644e-06	NA	0.986835744238421	0.170978870202674	0.767057556984365	0.124324963210678	Inf	0.382146811758261	lineage4	dr_mutations_pyrazinamide	PRO	1662	ERR2432989	lineage4.1.2.1	br	Brazil	pnca_p.ala3pro	A	E	ALA	AA3	pnca_complex.pdb
45	A3P	L4	PZA	A	A3	3	P	1	MDR	DM	hydrophobic	hydrophilic	non-polar	non-polar	non-polar	non-polar	18.028	-2.664	-1.124	-0.155697	-3.837	-0.13	66	80	-0.873	8	8	0	0	strand	0.366666666666667	8.38	7.18700589334483e-05	9.70142977291842	188179.926264599	Inf	0.763784339928386	0	0	0	0	0	0	0	0	-7	2	-7	-4	-2	-2	-1	-0.674772036474164	-0.290439276485788	-0.0299348227332154	-0.654219948849105	-0.0340314136125654	0.694736842105263	-0.719110378912685	Destabilising	Destabilising	Stabilising	Destabilising	Destabilising	effect	-0.993	-0.827	9:8	141/150	A:G:T:V:C	12.1451538387263	0.919026337424228	119.468044436222	0.101660271548263	5.01153666063644e-06	NA	0.986835744238421	0.170978870202674	0.767057556984365	0.124324963210678	Inf	0.382146811758261	lineage4	dr_mutations_pyrazinamide	PRO	10982	ERR3014600	lineage4.1.2.1	tn	Tunisia:Tunis	pnca_p.ala3pro	A	E	ALA	AA3	pnca_complex.pdb
46	L4S	L2	PZA	L	L4	4	S	1	MDR	DM	hydrophobic	hydrophilic	non-polar	neutral	non-polar	polar	15.328	-1.078	-3.87	5.57838	-2.638	-3.7	63	80	-1.075	9	9	0	0	strand	3.36666666666667	8.8	0.0024435820037372	28.4570212765957	28.4570177059942	28.4308865607855	107.057952768928	22	0	0	0	0	0	-2	0	-3	0	-1	-2	6	4	6	-0.273049645390071	-1	0.203176742254824	-0.449786871270247	-0.968586387434555	0.663157894736842	-0.885502471169687	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.152	-1.028	9:9	146/150	F:V:L:I	3.34839479820379	4.89069202996555e-12	0.484662577645081	6.90871330415739	12.0071584873314	83.7151686983107	1.4541894385859	5.6263316435115e-18	17.2497746719749	10.8739157094292	94.2522723934353	4.32340113554558e-25	lineage2	dr_mutations_pyrazinamide	SER	ERR2516880	ERR2516880	lineage2.2.1	gb	UK	pnca_p.leu4ser	A	E	LEU	LA4	pnca_complex.pdb
47	L4S	L3	PZA	L	L4	4	S	1	Pre-MDR	DM	hydrophobic	hydrophilic	non-polar	neutral	non-polar	polar	15.328	-1.078	-3.87	5.57838	-2.638	-3.7	63	80	-1.075	9	9	0	0	strand	3.36666666666667	8.8	0.0024435820037372	28.4570212765957	28.4570177059942	28.4308865607855	107.057952768928	22	0	0	0	0	0	-2	0	-3	0	-1	-2	6	4	6	-0.273049645390071	-1	0.203176742254824	-0.449786871270247	-0.968586387434555	0.663157894736842	-0.885502471169687	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.152	-1.028	9:9	146/150	F:V:L:I	3.34839479820379	4.89069202996555e-12	0.484662577645081	6.90871330415739	12.0071584873314	83.7151686983107	1.4541894385859	5.6263316435115e-18	17.2497746719749	10.8739157094292	94.2522723934353	4.32340113554558e-25	lineage3	dr_mutations_pyrazinamide	SER	ERR2510458	ERR2510458	lineage3.1.2.1	pk	Pakistan	pnca_p.leu4ser	A	E	LEU	LA4	pnca_complex.pdb
48	L4S	L4	PZA	L	L4	4	S	NA	MDR	DM	hydrophobic	hydrophilic	non-polar	neutral	non-polar	polar	15.328	-1.078	-3.87	5.57838	-2.638	-3.7	63	80	-1.075	9	9	0	0	strand	3.36666666666667	8.8	0.0024435820037372	28.4570212765957	28.4570177059942	28.4308865607855	107.057952768928	22	0	0	0	0	0	-2	0	-3	0	-1	-2	6	4	6	-0.273049645390071	-1	0.203176742254824	-0.449786871270247	-0.968586387434555	0.663157894736842	-0.885502471169687	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.152	-1.028	9:9	146/150	F:V:L:I	3.34839479820379	4.89069202996555e-12	0.484662577645081	6.90871330415739	12.0071584873314	83.7151686983107	1.4541894385859	5.6263316435115e-18	17.2497746719749	10.8739157094292	94.2522723934353	4.32340113554558e-25	lineage4	dr_mutations_pyrazinamide	SER	ERR2516569	ERR2516569	lineage4.3.3	nl	Netherlands	pnca_p.leu4ser	A	E	LEU	LA4	pnca_complex.pdb
49	L4S	L2	PZA	L	L4	4	S	1	MDR	DM	hydrophobic	hydrophilic	non-polar	neutral	non-polar	polar	15.328	-1.078	-3.87	5.57838	-2.638	-3.7	63	80	-1.075	9	9	0	0	strand	3.36666666666667	8.8	0.0024435820037372	28.4570212765957	28.4570177059942	28.4308865607855	107.057952768928	22	0	0	0	0	0	-2	0	-3	0	-1	-2	6	4	6	-0.273049645390071	-1	0.203176742254824	-0.449786871270247	-0.968586387434555	0.663157894736842	-0.885502471169687	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.152	-1.028	9:9	146/150	F:V:L:I	3.34839479820379	4.89069202996555e-12	0.484662577645081	6.90871330415739	12.0071584873314	83.7151686983107	1.4541894385859	5.6263316435115e-18	17.2497746719749	10.8739157094292	94.2522723934353	4.32340113554558e-25	lineage2	dr_mutations_pyrazinamide	SER	SRR2100387,SAMN03647560	SRR2100387	lineage2.2.1			pnca_p.leu4ser	A	E	LEU	LA4	pnca_complex.pdb
50	L4S	L2	PZA	L	L4	4	S	0	MDR	DM	hydrophobic	hydrophilic	non-polar	neutral	non-polar	polar	15.328	-1.078	-3.87	5.57838	-2.638	-3.7	63	80	-1.075	9	9	0	0	strand	3.36666666666667	8.8	0.0024435820037372	28.4570212765957	28.4570177059942	28.4308865607855	107.057952768928	22	0	0	0	0	0	-2	0	-3	0	-1	-2	6	4	6	-0.273049645390071	-1	0.203176742254824	-0.449786871270247	-0.968586387434555	0.663157894736842	-0.885502471169687	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.152	-1.028	9:9	146/150	F:V:L:I	3.34839479820379	4.89069202996555e-12	0.484662577645081	6.90871330415739	12.0071584873314	83.7151686983107	1.4541894385859	5.6263316435115e-18	17.2497746719749	10.8739157094292	94.2522723934353	4.32340113554558e-25	lineage2	dr_mutations_pyrazinamide	SER	ERR2516991	ERR2516991	lineage2.2.1	gb	UK	pnca_p.leu4ser	A	E	LEU	LA4	pnca_complex.pdb
51	L4S	L2	PZA	L	L4	4	S	0	MDR	DM	hydrophobic	hydrophilic	non-polar	neutral	non-polar	polar	15.328	-1.078	-3.87	5.57838	-2.638	-3.7	63	80	-1.075	9	9	0	0	strand	3.36666666666667	8.8	0.0024435820037372	28.4570212765957	28.4570177059942	28.4308865607855	107.057952768928	22	0	0	0	0	0	-2	0	-3	0	-1	-2	6	4	6	-0.273049645390071	-1	0.203176742254824	-0.449786871270247	-0.968586387434555	0.663157894736842	-0.885502471169687	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.152	-1.028	9:9	146/150	F:V:L:I	3.34839479820379	4.89069202996555e-12	0.484662577645081	6.90871330415739	12.0071584873314	83.7151686983107	1.4541894385859	5.6263316435115e-18	17.2497746719749	10.8739157094292	94.2522723934353	4.32340113554558e-25	lineage2	dr_mutations_pyrazinamide	SER	ERR2517006	ERR2517006	lineage2.2.1	gb	UK	pnca_p.leu4ser	A	E	LEU	LA4	pnca_complex.pdb
52	L4S	L2	PZA	L	L4	4	S	1	XDR	DM	hydrophobic	hydrophilic	non-polar	neutral	non-polar	polar	15.328	-1.078	-3.87	5.57838	-2.638	-3.7	63	80	-1.075	9	9	0	0	strand	3.36666666666667	8.8	0.0024435820037372	28.4570212765957	28.4570177059942	28.4308865607855	107.057952768928	22	0	0	0	0	0	-2	0	-3	0	-1	-2	6	4	6	-0.273049645390071	-1	0.203176742254824	-0.449786871270247	-0.968586387434555	0.663157894736842	-0.885502471169687	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.152	-1.028	9:9	146/150	F:V:L:I	3.34839479820379	4.89069202996555e-12	0.484662577645081	6.90871330415739	12.0071584873314	83.7151686983107	1.4541894385859	5.6263316435115e-18	17.2497746719749	10.8739157094292	94.2522723934353	4.32340113554558e-25	lineage2	dr_mutations_pyrazinamide	SER	ERS1831676	ERR2041944	lineage2.2.1		Germany_extendedCAO	pnca_p.leu4ser	A	E	LEU	LA4	pnca_complex.pdb
53	L4S	L2	PZA	L	L4	4	S	NA	MDR	DM	hydrophobic	hydrophilic	non-polar	neutral	non-polar	polar	15.328	-1.078	-3.87	5.57838	-2.638	-3.7	63	80	-1.075	9	9	0	0	strand	3.36666666666667	8.8	0.0024435820037372	28.4570212765957	28.4570177059942	28.4308865607855	107.057952768928	22	0	0	0	0	0	-2	0	-3	0	-1	-2	6	4	6	-0.273049645390071	-1	0.203176742254824	-0.449786871270247	-0.968586387434555	0.663157894736842	-0.885502471169687	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.152	-1.028	9:9	146/150	F:V:L:I	3.34839479820379	4.89069202996555e-12	0.484662577645081	6.90871330415739	12.0071584873314	83.7151686983107	1.4541894385859	5.6263316435115e-18	17.2497746719749	10.8739157094292	94.2522723934353	4.32340113554558e-25	lineage2	dr_mutations_pyrazinamide	SER	ERR1023353	ERR1023353	lineage2.2.1			pnca_p.leu4ser	A	E	LEU	LA4	pnca_complex.pdb
54	L4S	L4	PZA	L	L4	4	S	1	Pre-XDR	DM	hydrophobic	hydrophilic	non-polar	neutral	non-polar	polar	15.328	-1.078	-3.87	5.57838	-2.638	-3.7	63	80	-1.075	9	9	0	0	strand	3.36666666666667	8.8	0.0024435820037372	28.4570212765957	28.4570177059942	28.4308865607855	107.057952768928	22	0	0	0	0	0	-2	0	-3	0	-1	-2	6	4	6	-0.273049645390071	-1	0.203176742254824	-0.449786871270247	-0.968586387434555	0.663157894736842	-0.885502471169687	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.152	-1.028	9:9	146/150	F:V:L:I	3.34839479820379	4.89069202996555e-12	0.484662577645081	6.90871330415739	12.0071584873314	83.7151686983107	1.4541894385859	5.6263316435115e-18	17.2497746719749	10.8739157094292	94.2522723934353	4.32340113554558e-25	lineage4	dr_mutations_pyrazinamide	SER	ERR2513221	ERR2513221	lineage4	gb	UK	pnca_p.leu4ser	A	E	LEU	LA4	pnca_complex.pdb
55	L4S	L2	PZA	L	L4	4	S	NA	XDR	DM	hydrophobic	hydrophilic	non-polar	neutral	non-polar	polar	15.328	-1.078	-3.87	5.57838	-2.638	-3.7	63	80	-1.075	9	9	0	0	strand	3.36666666666667	8.8	0.0024435820037372	28.4570212765957	28.4570177059942	28.4308865607855	107.057952768928	22	0	0	0	0	0	-2	0	-3	0	-1	-2	6	4	6	-0.273049645390071	-1	0.203176742254824	-0.449786871270247	-0.968586387434555	0.663157894736842	-0.885502471169687	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.152	-1.028	9:9	146/150	F:V:L:I	3.34839479820379	4.89069202996555e-12	0.484662577645081	6.90871330415739	12.0071584873314	83.7151686983107	1.4541894385859	5.6263316435115e-18	17.2497746719749	10.8739157094292	94.2522723934353	4.32340113554558e-25	lineage2	dr_mutations_pyrazinamide	SER	BGI_GuangZ0017,SRR671864	SRR671864	lineage2.2.1	cn	China	pnca_p.leu4ser	A	E	LEU	LA4	pnca_complex.pdb
56	L4S	L2	PZA	L	L4	4	S	1	MDR	DM	hydrophobic	hydrophilic	non-polar	neutral	non-polar	polar	15.328	-1.078	-3.87	5.57838	-2.638	-3.7	63	80	-1.075	9	9	0	0	strand	3.36666666666667	8.8	0.0024435820037372	28.4570212765957	28.4570177059942	28.4308865607855	107.057952768928	22	0	0	0	0	0	-2	0	-3	0	-1	-2	6	4	6	-0.273049645390071	-1	0.203176742254824	-0.449786871270247	-0.968586387434555	0.663157894736842	-0.885502471169687	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.152	-1.028	9:9	146/150	F:V:L:I	3.34839479820379	4.89069202996555e-12	0.484662577645081	6.90871330415739	12.0071584873314	83.7151686983107	1.4541894385859	5.6263316435115e-18	17.2497746719749	10.8739157094292	94.2522723934353	4.32340113554558e-25	lineage2	dr_mutations_pyrazinamide	SER	ERR2513564	ERR2513564	lineage2.2.1	gb	UK	pnca_p.leu4ser	A	E	LEU	LA4	pnca_complex.pdb
57	L4S	L4	PZA	L	L4	4	S	1	MDR	DM	hydrophobic	hydrophilic	non-polar	neutral	non-polar	polar	15.328	-1.078	-3.87	5.57838	-2.638	-3.7	63	80	-1.075	9	9	0	0	strand	3.36666666666667	8.8	0.0024435820037372	28.4570212765957	28.4570177059942	28.4308865607855	107.057952768928	22	0	0	0	0	0	-2	0	-3	0	-1	-2	6	4	6	-0.273049645390071	-1	0.203176742254824	-0.449786871270247	-0.968586387434555	0.663157894736842	-0.885502471169687	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.152	-1.028	9:9	146/150	F:V:L:I	3.34839479820379	4.89069202996555e-12	0.484662577645081	6.90871330415739	12.0071584873314	83.7151686983107	1.4541894385859	5.6263316435115e-18	17.2497746719749	10.8739157094292	94.2522723934353	4.32340113554558e-25	lineage4	dr_mutations_pyrazinamide	SER	ERS2592809	ERR2677466	lineage4.2.2.1	de	Germany	pnca_p.leu4ser	A	E	LEU	LA4	pnca_complex.pdb
58	L4S	L2	PZA	L	L4	4	S	1	MDR	DM	hydrophobic	hydrophilic	non-polar	neutral	non-polar	polar	15.328	-1.078	-3.87	5.57838	-2.638	-3.7	63	80	-1.075	9	9	0	0	strand	3.36666666666667	8.8	0.0024435820037372	28.4570212765957	28.4570177059942	28.4308865607855	107.057952768928	22	0	0	0	0	0	-2	0	-3	0	-1	-2	6	4	6	-0.273049645390071	-1	0.203176742254824	-0.449786871270247	-0.968586387434555	0.663157894736842	-0.885502471169687	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.152	-1.028	9:9	146/150	F:V:L:I	3.34839479820379	4.89069202996555e-12	0.484662577645081	6.90871330415739	12.0071584873314	83.7151686983107	1.4541894385859	5.6263316435115e-18	17.2497746719749	10.8739157094292	94.2522723934353	4.32340113554558e-25	lineage2	dr_mutations_pyrazinamide	SER	ERR1034880	ERR1034880	lineage2.2.1	pt	Portugal	pnca_p.leu4ser	A	E	LEU	LA4	pnca_complex.pdb
59	L4S	L2	PZA	L	L4	4	S	1	MDR	DM	hydrophobic	hydrophilic	non-polar	neutral	non-polar	polar	15.328	-1.078	-3.87	5.57838	-2.638	-3.7	63	80	-1.075	9	9	0	0	strand	3.36666666666667	8.8	0.0024435820037372	28.4570212765957	28.4570177059942	28.4308865607855	107.057952768928	22	0	0	0	0	0	-2	0	-3	0	-1	-2	6	4	6	-0.273049645390071	-1	0.203176742254824	-0.449786871270247	-0.968586387434555	0.663157894736842	-0.885502471169687	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.152	-1.028	9:9	146/150	F:V:L:I	3.34839479820379	4.89069202996555e-12	0.484662577645081	6.90871330415739	12.0071584873314	83.7151686983107	1.4541894385859	5.6263316435115e-18	17.2497746719749	10.8739157094292	94.2522723934353	4.32340113554558e-25	lineage2	dr_mutations_pyrazinamide	SER	ERR2516854	ERR2516854	lineage2.2.1	gb	UK	pnca_p.leu4ser	A	E	LEU	LA4	pnca_complex.pdb
60	L4S	L2	PZA	L	L4	4	S	0	MDR	DM	hydrophobic	hydrophilic	non-polar	neutral	non-polar	polar	15.328	-1.078	-3.87	5.57838	-2.638	-3.7	63	80	-1.075	9	9	0	0	strand	3.36666666666667	8.8	0.0024435820037372	28.4570212765957	28.4570177059942	28.4308865607855	107.057952768928	22	0	0	0	0	0	-2	0	-3	0	-1	-2	6	4	6	-0.273049645390071	-1	0.203176742254824	-0.449786871270247	-0.968586387434555	0.663157894736842	-0.885502471169687	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.152	-1.028	9:9	146/150	F:V:L:I	3.34839479820379	4.89069202996555e-12	0.484662577645081	6.90871330415739	12.0071584873314	83.7151686983107	1.4541894385859	5.6263316435115e-18	17.2497746719749	10.8739157094292	94.2522723934353	4.32340113554558e-25	lineage2	dr_mutations_pyrazinamide	SER	ERR2513572	ERR2513572	lineage2.2.1	gb	UK	pnca_p.leu4ser	A	E	LEU	LA4	pnca_complex.pdb
61	L4S	L2	PZA	L	L4	4	S	1	MDR	DM	hydrophobic	hydrophilic	non-polar	neutral	non-polar	polar	15.328	-1.078	-3.87	5.57838	-2.638	-3.7	63	80	-1.075	9	9	0	0	strand	3.36666666666667	8.8	0.0024435820037372	28.4570212765957	28.4570177059942	28.4308865607855	107.057952768928	22	0	0	0	0	0	-2	0	-3	0	-1	-2	6	4	6	-0.273049645390071	-1	0.203176742254824	-0.449786871270247	-0.968586387434555	0.663157894736842	-0.885502471169687	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.152	-1.028	9:9	146/150	F:V:L:I	3.34839479820379	4.89069202996555e-12	0.484662577645081	6.90871330415739	12.0071584873314	83.7151686983107	1.4541894385859	5.6263316435115e-18	17.2497746719749	10.8739157094292	94.2522723934353	4.32340113554558e-25	lineage2	dr_mutations_pyrazinamide	SER	ERR2512591	ERR2512591	lineage2.2.1	gb	UK	pnca_p.leu4ser	A	E	LEU	LA4	pnca_complex.pdb
62	L4S	L4	PZA	L	L4	4	S	1	Other	DM	hydrophobic	hydrophilic	non-polar	neutral	non-polar	polar	15.328	-1.078	-3.87	5.57838	-2.638	-3.7	63	80	-1.075	9	9	0	0	strand	3.36666666666667	8.8	0.0024435820037372	28.4570212765957	28.4570177059942	28.4308865607855	107.057952768928	22	0	0	0	0	0	-2	0	-3	0	-1	-2	6	4	6	-0.273049645390071	-1	0.203176742254824	-0.449786871270247	-0.968586387434555	0.663157894736842	-0.885502471169687	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.152	-1.028	9:9	146/150	F:V:L:I	3.34839479820379	4.89069202996555e-12	0.484662577645081	6.90871330415739	12.0071584873314	83.7151686983107	1.4541894385859	5.6263316435115e-18	17.2497746719749	10.8739157094292	94.2522723934353	4.32340113554558e-25	lineage4	dr_mutations_pyrazinamide	SER	ERR2510742	ERR2510742	lineage4.1.2.1	it	Italy	pnca_p.leu4ser	A	E	LEU	LA4	pnca_complex.pdb
63	L4S	L2	PZA	L	L4	4	S	1	MDR	DM	hydrophobic	hydrophilic	non-polar	neutral	non-polar	polar	15.328	-1.078	-3.87	5.57838	-2.638	-3.7	63	80	-1.075	9	9	0	0	strand	3.36666666666667	8.8	0.0024435820037372	28.4570212765957	28.4570177059942	28.4308865607855	107.057952768928	22	0	0	0	0	0	-2	0	-3	0	-1	-2	6	4	6	-0.273049645390071	-1	0.203176742254824	-0.449786871270247	-0.968586387434555	0.663157894736842	-0.885502471169687	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.152	-1.028	9:9	146/150	F:V:L:I	3.34839479820379	4.89069202996555e-12	0.484662577645081	6.90871330415739	12.0071584873314	83.7151686983107	1.4541894385859	5.6263316435115e-18	17.2497746719749	10.8739157094292	94.2522723934353	4.32340113554558e-25	lineage2	dr_mutations_pyrazinamide	SER	SRR2100950,SAMN03648197	SRR2100950	lineage2.2.1			pnca_p.leu4ser	A	E	LEU	LA4	pnca_complex.pdb
64	L4S	L3	PZA	L	L4	4	S	1	MDR	DM	hydrophobic	hydrophilic	non-polar	neutral	non-polar	polar	15.328	-1.078	-3.87	5.57838	-2.638	-3.7	63	80	-1.075	9	9	0	0	strand	3.36666666666667	8.8	0.0024435820037372	28.4570212765957	28.4570177059942	28.4308865607855	107.057952768928	22	0	0	0	0	0	-2	0	-3	0	-1	-2	6	4	6	-0.273049645390071	-1	0.203176742254824	-0.449786871270247	-0.968586387434555	0.663157894736842	-0.885502471169687	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.152	-1.028	9:9	146/150	F:V:L:I	3.34839479820379	4.89069202996555e-12	0.484662577645081	6.90871330415739	12.0071584873314	83.7151686983107	1.4541894385859	5.6263316435115e-18	17.2497746719749	10.8739157094292	94.2522723934353	4.32340113554558e-25	lineage3	dr_mutations_pyrazinamide	SER	ERR2510570	ERR2510570	lineage3	pk	Pakistan	pnca_p.leu4ser	A	E	LEU	LA4	pnca_complex.pdb
65	L4S	L2	PZA	L	L4	4	S	NA	XDR	DM	hydrophobic	hydrophilic	non-polar	neutral	non-polar	polar	15.328	-1.078	-3.87	5.57838	-2.638	-3.7	63	80	-1.075	9	9	0	0	strand	3.36666666666667	8.8	0.0024435820037372	28.4570212765957	28.4570177059942	28.4308865607855	107.057952768928	22	0	0	0	0	0	-2	0	-3	0	-1	-2	6	4	6	-0.273049645390071	-1	0.203176742254824	-0.449786871270247	-0.968586387434555	0.663157894736842	-0.885502471169687	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.152	-1.028	9:9	146/150	F:V:L:I	3.34839479820379	4.89069202996555e-12	0.484662577645081	6.90871330415739	12.0071584873314	83.7151686983107	1.4541894385859	5.6263316435115e-18	17.2497746719749	10.8739157094292	94.2522723934353	4.32340113554558e-25	lineage2	dr_mutations_pyrazinamide	SER	SRR5266534	SRR5266534	lineage2.2.1	ru	Russia	pnca_p.leu4ser	A	E	LEU	LA4	pnca_complex.pdb
66	L4S	L4	PZA	L	L4	4	S	NA	Pre-XDR	DM	hydrophobic	hydrophilic	non-polar	neutral	non-polar	polar	15.328	-1.078	-3.87	5.57838	-2.638	-3.7	63	80	-1.075	9	9	0	0	strand	3.36666666666667	8.8	0.0024435820037372	28.4570212765957	28.4570177059942	28.4308865607855	107.057952768928	22	0	0	0	0	0	-2	0	-3	0	-1	-2	6	4	6	-0.273049645390071	-1	0.203176742254824	-0.449786871270247	-0.968586387434555	0.663157894736842	-0.885502471169687	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.152	-1.028	9:9	146/150	F:V:L:I	3.34839479820379	4.89069202996555e-12	0.484662577645081	6.90871330415739	12.0071584873314	83.7151686983107	1.4541894385859	5.6263316435115e-18	17.2497746719749	10.8739157094292	94.2522723934353	4.32340113554558e-25	lineage4	dr_mutations_pyrazinamide	SER	SAMN02381040	SRR1049730_SRR1140739_SRR1049729_SRR1062930	lineage4	ug	Uganda	pnca_p.leu4ser	A	E	LEU	LA4	pnca_complex.pdb
67	L4S	L2	PZA	L	L4	4	S	1	MDR	DM	hydrophobic	hydrophilic	non-polar	neutral	non-polar	polar	15.328	-1.078	-3.87	5.57838	-2.638	-3.7	63	80	-1.075	9	9	0	0	strand	3.36666666666667	8.8	0.0024435820037372	28.4570212765957	28.4570177059942	28.4308865607855	107.057952768928	22	0	0	0	0	0	-2	0	-3	0	-1	-2	6	4	6	-0.273049645390071	-1	0.203176742254824	-0.449786871270247	-0.968586387434555	0.663157894736842	-0.885502471169687	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.152	-1.028	9:9	146/150	F:V:L:I	3.34839479820379	4.89069202996555e-12	0.484662577645081	6.90871330415739	12.0071584873314	83.7151686983107	1.4541894385859	5.6263316435115e-18	17.2497746719749	10.8739157094292	94.2522723934353	4.32340113554558e-25	lineage2	dr_mutations_pyrazinamide	SER	ERR2512419	ERR2512419	lineage2.2.1	gb	UK	pnca_p.leu4ser	A	E	LEU	LA4	pnca_complex.pdb
68	L4S	L2	PZA	L	L4	4	S	NA	XDR	DM	hydrophobic	hydrophilic	non-polar	neutral	non-polar	polar	15.328	-1.078	-3.87	5.57838	-2.638	-3.7	63	80	-1.075	9	9	0	0	strand	3.36666666666667	8.8	0.0024435820037372	28.4570212765957	28.4570177059942	28.4308865607855	107.057952768928	22	0	0	0	0	0	-2	0	-3	0	-1	-2	6	4	6	-0.273049645390071	-1	0.203176742254824	-0.449786871270247	-0.968586387434555	0.663157894736842	-0.885502471169687	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.152	-1.028	9:9	146/150	F:V:L:I	3.34839479820379	4.89069202996555e-12	0.484662577645081	6.90871330415739	12.0071584873314	83.7151686983107	1.4541894385859	5.6263316435115e-18	17.2497746719749	10.8739157094292	94.2522723934353	4.32340113554558e-25	lineage2	dr_mutations_pyrazinamide	SER	SAMN02628490	SRR1173490_SRR1173844	lineage2.2.1	ir	Iran	pnca_p.leu4ser	A	E	LEU	LA4	pnca_complex.pdb
69	L4S	L2	PZA	L	L4	4	S	NA	XDR	DM	hydrophobic	hydrophilic	non-polar	neutral	non-polar	polar	15.328	-1.078	-3.87	5.57838	-2.638	-3.7	63	80	-1.075	9	9	0	0	strand	3.36666666666667	8.8	0.0024435820037372	28.4570212765957	28.4570177059942	28.4308865607855	107.057952768928	22	0	0	0	0	0	-2	0	-3	0	-1	-2	6	4	6	-0.273049645390071	-1	0.203176742254824	-0.449786871270247	-0.968586387434555	0.663157894736842	-0.885502471169687	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.152	-1.028	9:9	146/150	F:V:L:I	3.34839479820379	4.89069202996555e-12	0.484662577645081	6.90871330415739	12.0071584873314	83.7151686983107	1.4541894385859	5.6263316435115e-18	17.2497746719749	10.8739157094292	94.2522723934353	4.32340113554558e-25	lineage2	dr_mutations_pyrazinamide	SER	SRR671789,BGI_GuangZ24	SRR671789	lineage2.2.1	cn	China	pnca_p.leu4ser	A	E	LEU	LA4	pnca_complex.pdb
70	L4S	L4	PZA	L	L4	4	S	1	Pre-XDR	DM	hydrophobic	hydrophilic	non-polar	neutral	non-polar	polar	15.328	-1.078	-3.87	5.57838	-2.638	-3.7	63	80	-1.075	9	9	0	0	strand	3.36666666666667	8.8	0.0024435820037372	28.4570212765957	28.4570177059942	28.4308865607855	107.057952768928	22	0	0	0	0	0	-2	0	-3	0	-1	-2	6	4	6	-0.273049645390071	-1	0.203176742254824	-0.449786871270247	-0.968586387434555	0.663157894736842	-0.885502471169687	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.152	-1.028	9:9	146/150	F:V:L:I	3.34839479820379	4.89069202996555e-12	0.484662577645081	6.90871330415739	12.0071584873314	83.7151686983107	1.4541894385859	5.6263316435115e-18	17.2497746719749	10.8739157094292	94.2522723934353	4.32340113554558e-25	lineage4	dr_mutations_pyrazinamide	SER	ERR2514395	ERR2514395	lineage4	gb	UK	pnca_p.leu4ser	A	E	LEU	LA4	pnca_complex.pdb
71	L4S	L2	PZA	L	L4	4	S	1	MDR	DM	hydrophobic	hydrophilic	non-polar	neutral	non-polar	polar	15.328	-1.078	-3.87	5.57838	-2.638	-3.7	63	80	-1.075	9	9	0	0	strand	3.36666666666667	8.8	0.0024435820037372	28.4570212765957	28.4570177059942	28.4308865607855	107.057952768928	22	0	0	0	0	0	-2	0	-3	0	-1	-2	6	4	6	-0.273049645390071	-1	0.203176742254824	-0.449786871270247	-0.968586387434555	0.663157894736842	-0.885502471169687	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.152	-1.028	9:9	146/150	F:V:L:I	3.34839479820379	4.89069202996555e-12	0.484662577645081	6.90871330415739	12.0071584873314	83.7151686983107	1.4541894385859	5.6263316435115e-18	17.2497746719749	10.8739157094292	94.2522723934353	4.32340113554558e-25	lineage2	dr_mutations_pyrazinamide	SER	ERR2516822	ERR2516822	lineage2.2.1	gb	UK	pnca_p.leu4ser	A	E	LEU	LA4	pnca_complex.pdb
72	L4S	L2	PZA	L	L4	4	S	1	MDR	DM	hydrophobic	hydrophilic	non-polar	neutral	non-polar	polar	15.328	-1.078	-3.87	5.57838	-2.638	-3.7	63	80	-1.075	9	9	0	0	strand	3.36666666666667	8.8	0.0024435820037372	28.4570212765957	28.4570177059942	28.4308865607855	107.057952768928	22	0	0	0	0	0	-2	0	-3	0	-1	-2	6	4	6	-0.273049645390071	-1	0.203176742254824	-0.449786871270247	-0.968586387434555	0.663157894736842	-0.885502471169687	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.152	-1.028	9:9	146/150	F:V:L:I	3.34839479820379	4.89069202996555e-12	0.484662577645081	6.90871330415739	12.0071584873314	83.7151686983107	1.4541894385859	5.6263316435115e-18	17.2497746719749	10.8739157094292	94.2522723934353	4.32340113554558e-25	lineage2	dr_mutations_pyrazinamide	SER	ERR2517099	ERR2517099	lineage2.2.1	gb	UK	pnca_p.leu4ser	A	E	LEU	LA4	pnca_complex.pdb
73	L4S	L4	PZA	L	L4	4	S	NA	MDR	DM	hydrophobic	hydrophilic	non-polar	neutral	non-polar	polar	15.328	-1.078	-3.87	5.57838	-2.638	-3.7	63	80	-1.075	9	9	0	0	strand	3.36666666666667	8.8	0.0024435820037372	28.4570212765957	28.4570177059942	28.4308865607855	107.057952768928	22	0	0	0	0	0	-2	0	-3	0	-1	-2	6	4	6	-0.273049645390071	-1	0.203176742254824	-0.449786871270247	-0.968586387434555	0.663157894736842	-0.885502471169687	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.152	-1.028	9:9	146/150	F:V:L:I	3.34839479820379	4.89069202996555e-12	0.484662577645081	6.90871330415739	12.0071584873314	83.7151686983107	1.4541894385859	5.6263316435115e-18	17.2497746719749	10.8739157094292	94.2522723934353	4.32340113554558e-25	lineage4	dr_mutations_pyrazinamide	SER	ERR2516432	ERR2516432	lineage4.3.3	nl	Netherlands	pnca_p.leu4ser	A	E	LEU	LA4	pnca_complex.pdb
74	L4S	L4	PZA	L	L4	4	S	1	MDR	DM	hydrophobic	hydrophilic	non-polar	neutral	non-polar	polar	15.328	-1.078	-3.87	5.57838	-2.638	-3.7	63	80	-1.075	9	9	0	0	strand	3.36666666666667	8.8	0.0024435820037372	28.4570212765957	28.4570177059942	28.4308865607855	107.057952768928	22	0	0	0	0	0	-2	0	-3	0	-1	-2	6	4	6	-0.273049645390071	-1	0.203176742254824	-0.449786871270247	-0.968586387434555	0.663157894736842	-0.885502471169687	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.152	-1.028	9:9	146/150	F:V:L:I	3.34839479820379	4.89069202996555e-12	0.484662577645081	6.90871330415739	12.0071584873314	83.7151686983107	1.4541894385859	5.6263316435115e-18	17.2497746719749	10.8739157094292	94.2522723934353	4.32340113554558e-25	lineage4	dr_mutations_pyrazinamide	SER	ERR040137	ERR040137	lineage4.1.1.3	ug	Uganda	pnca_p.leu4ser	A	E	LEU	LA4	pnca_complex.pdb
75	L4S	L2	PZA	L	L4	4	S	1	MDR	DM	hydrophobic	hydrophilic	non-polar	neutral	non-polar	polar	15.328	-1.078	-3.87	5.57838	-2.638	-3.7	63	80	-1.075	9	9	0	0	strand	3.36666666666667	8.8	0.0024435820037372	28.4570212765957	28.4570177059942	28.4308865607855	107.057952768928	22	0	0	0	0	0	-2	0	-3	0	-1	-2	6	4	6	-0.273049645390071	-1	0.203176742254824	-0.449786871270247	-0.968586387434555	0.663157894736842	-0.885502471169687	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.152	-1.028	9:9	146/150	F:V:L:I	3.34839479820379	4.89069202996555e-12	0.484662577645081	6.90871330415739	12.0071584873314	83.7151686983107	1.4541894385859	5.6263316435115e-18	17.2497746719749	10.8739157094292	94.2522723934353	4.32340113554558e-25	lineage2	dr_mutations_pyrazinamide	SER	ERR2517053	ERR2517053	lineage2.2.1	gb	UK	pnca_p.leu4ser	A	E	LEU	LA4	pnca_complex.pdb
76	L4S	L1;L4	PZA	L	L4	4	S	NA	Pre-MDR	DM	hydrophobic	hydrophilic	non-polar	neutral	non-polar	polar	15.328	-1.078	-3.87	5.57838	-2.638	-3.7	63	80	-1.075	9	9	0	0	strand	3.36666666666667	8.8	0.0024435820037372	28.4570212765957	28.4570177059942	28.4308865607855	107.057952768928	22	0	0	0	0	0	-2	0	-3	0	-1	-2	6	4	6	-0.273049645390071	-1	0.203176742254824	-0.449786871270247	-0.968586387434555	0.663157894736842	-0.885502471169687	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.152	-1.028	9:9	146/150	F:V:L:I	3.34839479820379	4.89069202996555e-12	0.484662577645081	6.90871330415739	12.0071584873314	83.7151686983107	1.4541894385859	5.6263316435115e-18	17.2497746719749	10.8739157094292	94.2522723934353	4.32340113554558e-25	lineage1;lineage4	dr_mutations_pyrazinamide	SER	ERR2706927	ERR2706927	lineage4.7;lineage1.1.3	cd	Democratic Republic of Congo	pnca_p.leu4ser	A	E	LEU	LA4	pnca_complex.pdb
77	L4S	L4	PZA	L	L4	4	S	NA	MDR	DM	hydrophobic	hydrophilic	non-polar	neutral	non-polar	polar	15.328	-1.078	-3.87	5.57838	-2.638	-3.7	63	80	-1.075	9	9	0	0	strand	3.36666666666667	8.8	0.0024435820037372	28.4570212765957	28.4570177059942	28.4308865607855	107.057952768928	22	0	0	0	0	0	-2	0	-3	0	-1	-2	6	4	6	-0.273049645390071	-1	0.203176742254824	-0.449786871270247	-0.968586387434555	0.663157894736842	-0.885502471169687	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.152	-1.028	9:9	146/150	F:V:L:I	3.34839479820379	4.89069202996555e-12	0.484662577645081	6.90871330415739	12.0071584873314	83.7151686983107	1.4541894385859	5.6263316435115e-18	17.2497746719749	10.8739157094292	94.2522723934353	4.32340113554558e-25	lineage4	dr_mutations_pyrazinamide	SER	ERR751550	ERR751550	lineage4.3.3	pe		pnca_p.leu4ser	A	E	LEU	LA4	pnca_complex.pdb
78	L4S	L4	PZA	L	L4	4	S	1	MDR	DM	hydrophobic	hydrophilic	non-polar	neutral	non-polar	polar	15.328	-1.078	-3.87	5.57838	-2.638	-3.7	63	80	-1.075	9	9	0	0	strand	3.36666666666667	8.8	0.0024435820037372	28.4570212765957	28.4570177059942	28.4308865607855	107.057952768928	22	0	0	0	0	0	-2	0	-3	0	-1	-2	6	4	6	-0.273049645390071	-1	0.203176742254824	-0.449786871270247	-0.968586387434555	0.663157894736842	-0.885502471169687	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.152	-1.028	9:9	146/150	F:V:L:I	3.34839479820379	4.89069202996555e-12	0.484662577645081	6.90871330415739	12.0071584873314	83.7151686983107	1.4541894385859	5.6263316435115e-18	17.2497746719749	10.8739157094292	94.2522723934353	4.32340113554558e-25	lineage4	dr_mutations_pyrazinamide	SER	ERR2516671	ERR2516671	lineage4.3.3	nl	Netherlands	pnca_p.leu4ser	A	E	LEU	LA4	pnca_complex.pdb
79	L4S	L4	PZA	L	L4	4	S	NA	Other	DM	hydrophobic	hydrophilic	non-polar	neutral	non-polar	polar	15.328	-1.078	-3.87	5.57838	-2.638	-3.7	63	80	-1.075	9	9	0	0	strand	3.36666666666667	8.8	0.0024435820037372	28.4570212765957	28.4570177059942	28.4308865607855	107.057952768928	22	0	0	0	0	0	-2	0	-3	0	-1	-2	6	4	6	-0.273049645390071	-1	0.203176742254824	-0.449786871270247	-0.968586387434555	0.663157894736842	-0.885502471169687	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.152	-1.028	9:9	146/150	F:V:L:I	3.34839479820379	4.89069202996555e-12	0.484662577645081	6.90871330415739	12.0071584873314	83.7151686983107	1.4541894385859	5.6263316435115e-18	17.2497746719749	10.8739157094292	94.2522723934353	4.32340113554558e-25	lineage4	dr_mutations_pyrazinamide	SER	SRR4035802	SRR4035802	lineage4.1.2	za	South Africa: Kwazulu-Natal	pnca_p.leu4ser	A	E	LEU	LA4	pnca_complex.pdb
80	L4S	L1	PZA	L	L4	4	S	NA	MDR	DM	hydrophobic	hydrophilic	non-polar	neutral	non-polar	polar	15.328	-1.078	-3.87	5.57838	-2.638	-3.7	63	80	-1.075	9	9	0	0	strand	3.36666666666667	8.8	0.0024435820037372	28.4570212765957	28.4570177059942	28.4308865607855	107.057952768928	22	0	0	0	0	0	-2	0	-3	0	-1	-2	6	4	6	-0.273049645390071	-1	0.203176742254824	-0.449786871270247	-0.968586387434555	0.663157894736842	-0.885502471169687	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.152	-1.028	9:9	146/150	F:V:L:I	3.34839479820379	4.89069202996555e-12	0.484662577645081	6.90871330415739	12.0071584873314	83.7151686983107	1.4541894385859	5.6263316435115e-18	17.2497746719749	10.8739157094292	94.2522723934353	4.32340113554558e-25	lineage1	dr_mutations_pyrazinamide	SER	SRR6397957	SRR6397957	lineage1.2.1	ca	Canada	pnca_p.leu4ser	A	E	LEU	LA4	pnca_complex.pdb
81	L4S	L2	PZA	L	L4	4	S	0	MDR	DM	hydrophobic	hydrophilic	non-polar	neutral	non-polar	polar	15.328	-1.078	-3.87	5.57838	-2.638	-3.7	63	80	-1.075	9	9	0	0	strand	3.36666666666667	8.8	0.0024435820037372	28.4570212765957	28.4570177059942	28.4308865607855	107.057952768928	22	0	0	0	0	0	-2	0	-3	0	-1	-2	6	4	6	-0.273049645390071	-1	0.203176742254824	-0.449786871270247	-0.968586387434555	0.663157894736842	-0.885502471169687	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.152	-1.028	9:9	146/150	F:V:L:I	3.34839479820379	4.89069202996555e-12	0.484662577645081	6.90871330415739	12.0071584873314	83.7151686983107	1.4541894385859	5.6263316435115e-18	17.2497746719749	10.8739157094292	94.2522723934353	4.32340113554558e-25	lineage2	dr_mutations_pyrazinamide	SER	ERR2516916	ERR2516916	lineage2.2.1	gb	UK	pnca_p.leu4ser	A	E	LEU	LA4	pnca_complex.pdb
82	L4S	L4	PZA	L	L4	4	S	NA	MDR	DM	hydrophobic	hydrophilic	non-polar	neutral	non-polar	polar	15.328	-1.078	-3.87	5.57838	-2.638	-3.7	63	80	-1.075	9	9	0	0	strand	3.36666666666667	8.8	0.0024435820037372	28.4570212765957	28.4570177059942	28.4308865607855	107.057952768928	22	0	0	0	0	0	-2	0	-3	0	-1	-2	6	4	6	-0.273049645390071	-1	0.203176742254824	-0.449786871270247	-0.968586387434555	0.663157894736842	-0.885502471169687	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.152	-1.028	9:9	146/150	F:V:L:I	3.34839479820379	4.89069202996555e-12	0.484662577645081	6.90871330415739	12.0071584873314	83.7151686983107	1.4541894385859	5.6263316435115e-18	17.2497746719749	10.8739157094292	94.2522723934353	4.32340113554558e-25	lineage4	dr_mutations_pyrazinamide	SER	ERR3256132	ERR3256132	lineage4.5	ph	Philippines	pnca_p.leu4ser	A	E	LEU	LA4	pnca_complex.pdb
83	L4S	L2	PZA	L	L4	4	S	NA	MDR	DM	hydrophobic	hydrophilic	non-polar	neutral	non-polar	polar	15.328	-1.078	-3.87	5.57838	-2.638	-3.7	63	80	-1.075	9	9	0	0	strand	3.36666666666667	8.8	0.0024435820037372	28.4570212765957	28.4570177059942	28.4308865607855	107.057952768928	22	0	0	0	0	0	-2	0	-3	0	-1	-2	6	4	6	-0.273049645390071	-1	0.203176742254824	-0.449786871270247	-0.968586387434555	0.663157894736842	-0.885502471169687	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.152	-1.028	9:9	146/150	F:V:L:I	3.34839479820379	4.89069202996555e-12	0.484662577645081	6.90871330415739	12.0071584873314	83.7151686983107	1.4541894385859	5.6263316435115e-18	17.2497746719749	10.8739157094292	94.2522723934353	4.32340113554558e-25	lineage2	dr_mutations_pyrazinamide	SER	SAMN02414900	SRR1163039_SRR1163448_SRR1146378_SRR1144756	lineage2.2.1	se	Sweden	pnca_p.leu4ser	A	E	LEU	LA4	pnca_complex.pdb
84	L4S	L2	PZA	L	L4	4	S	NA	XDR	DM	hydrophobic	hydrophilic	non-polar	neutral	non-polar	polar	15.328	-1.078	-3.87	5.57838	-2.638	-3.7	63	80	-1.075	9	9	0	0	strand	3.36666666666667	8.8	0.0024435820037372	28.4570212765957	28.4570177059942	28.4308865607855	107.057952768928	22	0	0	0	0	0	-2	0	-3	0	-1	-2	6	4	6	-0.273049645390071	-1	0.203176742254824	-0.449786871270247	-0.968586387434555	0.663157894736842	-0.885502471169687	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.152	-1.028	9:9	146/150	F:V:L:I	3.34839479820379	4.89069202996555e-12	0.484662577645081	6.90871330415739	12.0071584873314	83.7151686983107	1.4541894385859	5.6263316435115e-18	17.2497746719749	10.8739157094292	94.2522723934353	4.32340113554558e-25	lineage2	dr_mutations_pyrazinamide	SER	SRR671863,BGI_GuangZ0008	SRR671863	lineage2.2.1	cn	China	pnca_p.leu4ser	A	E	LEU	LA4	pnca_complex.pdb
85	L4S	L4	PZA	L	L4	4	S	NA	MDR	DM	hydrophobic	hydrophilic	non-polar	neutral	non-polar	polar	15.328	-1.078	-3.87	5.57838	-2.638	-3.7	63	80	-1.075	9	9	0	0	strand	3.36666666666667	8.8	0.0024435820037372	28.4570212765957	28.4570177059942	28.4308865607855	107.057952768928	22	0	0	0	0	0	-2	0	-3	0	-1	-2	6	4	6	-0.273049645390071	-1	0.203176742254824	-0.449786871270247	-0.968586387434555	0.663157894736842	-0.885502471169687	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.152	-1.028	9:9	146/150	F:V:L:I	3.34839479820379	4.89069202996555e-12	0.484662577645081	6.90871330415739	12.0071584873314	83.7151686983107	1.4541894385859	5.6263316435115e-18	17.2497746719749	10.8739157094292	94.2522723934353	4.32340113554558e-25	lineage4	dr_mutations_pyrazinamide	SER	ERR1193648	ERR1193648	lineage4.3.3	so	Somalia	pnca_p.leu4ser	A	E	LEU	LA4	pnca_complex.pdb
86	L4S	L2	PZA	L	L4	4	S	1	MDR	DM	hydrophobic	hydrophilic	non-polar	neutral	non-polar	polar	15.328	-1.078	-3.87	5.57838	-2.638	-3.7	63	80	-1.075	9	9	0	0	strand	3.36666666666667	8.8	0.0024435820037372	28.4570212765957	28.4570177059942	28.4308865607855	107.057952768928	22	0	0	0	0	0	-2	0	-3	0	-1	-2	6	4	6	-0.273049645390071	-1	0.203176742254824	-0.449786871270247	-0.968586387434555	0.663157894736842	-0.885502471169687	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.152	-1.028	9:9	146/150	F:V:L:I	3.34839479820379	4.89069202996555e-12	0.484662577645081	6.90871330415739	12.0071584873314	83.7151686983107	1.4541894385859	5.6263316435115e-18	17.2497746719749	10.8739157094292	94.2522723934353	4.32340113554558e-25	lineage2	dr_mutations_pyrazinamide	SER	SRR2100306,SAMN03647479	SRR2100306	lineage2.2.1			pnca_p.leu4ser	A	E	LEU	LA4	pnca_complex.pdb
87	L4S	L4	PZA	L	L4	4	S	NA	MDR	DM	hydrophobic	hydrophilic	non-polar	neutral	non-polar	polar	15.328	-1.078	-3.87	5.57838	-2.638	-3.7	63	80	-1.075	9	9	0	0	strand	3.36666666666667	8.8	0.0024435820037372	28.4570212765957	28.4570177059942	28.4308865607855	107.057952768928	22	0	0	0	0	0	-2	0	-3	0	-1	-2	6	4	6	-0.273049645390071	-1	0.203176742254824	-0.449786871270247	-0.968586387434555	0.663157894736842	-0.885502471169687	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.152	-1.028	9:9	146/150	F:V:L:I	3.34839479820379	4.89069202996555e-12	0.484662577645081	6.90871330415739	12.0071584873314	83.7151686983107	1.4541894385859	5.6263316435115e-18	17.2497746719749	10.8739157094292	94.2522723934353	4.32340113554558e-25	lineage4	dr_mutations_pyrazinamide	SER	SRR7517813	SRR7517813	lineage4.3.3	pe	Peru	pnca_p.leu4ser	A	E	LEU	LA4	pnca_complex.pdb
88	L4S	L4	PZA	L	L4	4	S	0	MDR	DM	hydrophobic	hydrophilic	non-polar	neutral	non-polar	polar	15.328	-1.078	-3.87	5.57838	-2.638	-3.7	63	80	-1.075	9	9	0	0	strand	3.36666666666667	8.8	0.0024435820037372	28.4570212765957	28.4570177059942	28.4308865607855	107.057952768928	22	0	0	0	0	0	-2	0	-3	0	-1	-2	6	4	6	-0.273049645390071	-1	0.203176742254824	-0.449786871270247	-0.968586387434555	0.663157894736842	-0.885502471169687	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.152	-1.028	9:9	146/150	F:V:L:I	3.34839479820379	4.89069202996555e-12	0.484662577645081	6.90871330415739	12.0071584873314	83.7151686983107	1.4541894385859	5.6263316435115e-18	17.2497746719749	10.8739157094292	94.2522723934353	4.32340113554558e-25	lineage4	dr_mutations_pyrazinamide	SER	ERR2516552	ERR2516552	lineage4.3.3	pe	Peru	pnca_p.leu4ser	A	E	LEU	LA4	pnca_complex.pdb
89	L4S	L2	PZA	L	L4	4	S	1	MDR	DM	hydrophobic	hydrophilic	non-polar	neutral	non-polar	polar	15.328	-1.078	-3.87	5.57838	-2.638	-3.7	63	80	-1.075	9	9	0	0	strand	3.36666666666667	8.8	0.0024435820037372	28.4570212765957	28.4570177059942	28.4308865607855	107.057952768928	22	0	0	0	0	0	-2	0	-3	0	-1	-2	6	4	6	-0.273049645390071	-1	0.203176742254824	-0.449786871270247	-0.968586387434555	0.663157894736842	-0.885502471169687	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.152	-1.028	9:9	146/150	F:V:L:I	3.34839479820379	4.89069202996555e-12	0.484662577645081	6.90871330415739	12.0071584873314	83.7151686983107	1.4541894385859	5.6263316435115e-18	17.2497746719749	10.8739157094292	94.2522723934353	4.32340113554558e-25	lineage2	dr_mutations_pyrazinamide	SER	ERR2516882	ERR2516882	lineage2.2.1	gb	UK	pnca_p.leu4ser	A	E	LEU	LA4	pnca_complex.pdb
90	L4S	L4	PZA	L	L4	4	S	1	MDR	DM	hydrophobic	hydrophilic	non-polar	neutral	non-polar	polar	15.328	-1.078	-3.87	5.57838	-2.638	-3.7	63	80	-1.075	9	9	0	0	strand	3.36666666666667	8.8	0.0024435820037372	28.4570212765957	28.4570177059942	28.4308865607855	107.057952768928	22	0	0	0	0	0	-2	0	-3	0	-1	-2	6	4	6	-0.273049645390071	-1	0.203176742254824	-0.449786871270247	-0.968586387434555	0.663157894736842	-0.885502471169687	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.152	-1.028	9:9	146/150	F:V:L:I	3.34839479820379	4.89069202996555e-12	0.484662577645081	6.90871330415739	12.0071584873314	83.7151686983107	1.4541894385859	5.6263316435115e-18	17.2497746719749	10.8739157094292	94.2522723934353	4.32340113554558e-25	lineage4	dr_mutations_pyrazinamide	SER	ERR2516638	ERR2516638	lineage4.3.3	nl	Netherlands	pnca_p.leu4ser	A	E	LEU	LA4	pnca_complex.pdb
91	L4S	L2	PZA	L	L4	4	S	1	MDR	DM	hydrophobic	hydrophilic	non-polar	neutral	non-polar	polar	15.328	-1.078	-3.87	5.57838	-2.638	-3.7	63	80	-1.075	9	9	0	0	strand	3.36666666666667	8.8	0.0024435820037372	28.4570212765957	28.4570177059942	28.4308865607855	107.057952768928	22	0	0	0	0	0	-2	0	-3	0	-1	-2	6	4	6	-0.273049645390071	-1	0.203176742254824	-0.449786871270247	-0.968586387434555	0.663157894736842	-0.885502471169687	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.152	-1.028	9:9	146/150	F:V:L:I	3.34839479820379	4.89069202996555e-12	0.484662577645081	6.90871330415739	12.0071584873314	83.7151686983107	1.4541894385859	5.6263316435115e-18	17.2497746719749	10.8739157094292	94.2522723934353	4.32340113554558e-25	lineage2	dr_mutations_pyrazinamide	SER	ERR2513835	ERR2513835	lineage2.2.1	gb	UK	pnca_p.leu4ser	A	E	LEU	LA4	pnca_complex.pdb
92	L4S	L4	PZA	L	L4	4	S	NA	MDR	DM	hydrophobic	hydrophilic	non-polar	neutral	non-polar	polar	15.328	-1.078	-3.87	5.57838	-2.638	-3.7	63	80	-1.075	9	9	0	0	strand	3.36666666666667	8.8	0.0024435820037372	28.4570212765957	28.4570177059942	28.4308865607855	107.057952768928	22	0	0	0	0	0	-2	0	-3	0	-1	-2	6	4	6	-0.273049645390071	-1	0.203176742254824	-0.449786871270247	-0.968586387434555	0.663157894736842	-0.885502471169687	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.152	-1.028	9:9	146/150	F:V:L:I	3.34839479820379	4.89069202996555e-12	0.484662577645081	6.90871330415739	12.0071584873314	83.7151686983107	1.4541894385859	5.6263316435115e-18	17.2497746719749	10.8739157094292	94.2522723934353	4.32340113554558e-25	lineage4	dr_mutations_pyrazinamide	SER	ERR2707005	ERR2707005	lineage4.7	cd	Democratic Republic of Congo	pnca_p.leu4ser	A	E	LEU	LA4	pnca_complex.pdb
93	L4S	L2	PZA	L	L4	4	S	1	Pre-XDR	DM	hydrophobic	hydrophilic	non-polar	neutral	non-polar	polar	15.328	-1.078	-3.87	5.57838	-2.638	-3.7	63	80	-1.075	9	9	0	0	strand	3.36666666666667	8.8	0.0024435820037372	28.4570212765957	28.4570177059942	28.4308865607855	107.057952768928	22	0	0	0	0	0	-2	0	-3	0	-1	-2	6	4	6	-0.273049645390071	-1	0.203176742254824	-0.449786871270247	-0.968586387434555	0.663157894736842	-0.885502471169687	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.152	-1.028	9:9	146/150	F:V:L:I	3.34839479820379	4.89069202996555e-12	0.484662577645081	6.90871330415739	12.0071584873314	83.7151686983107	1.4541894385859	5.6263316435115e-18	17.2497746719749	10.8739157094292	94.2522723934353	4.32340113554558e-25	lineage2	dr_mutations_pyrazinamide	SER	ERS2592754	ERR2677405	lineage2.2.1	de	Germany	pnca_p.leu4ser	A	E	LEU	LA4	pnca_complex.pdb
94	L4S	L4	PZA	L	L4	4	S	NA	Pre-XDR	DM	hydrophobic	hydrophilic	non-polar	neutral	non-polar	polar	15.328	-1.078	-3.87	5.57838	-2.638	-3.7	63	80	-1.075	9	9	0	0	strand	3.36666666666667	8.8	0.0024435820037372	28.4570212765957	28.4570177059942	28.4308865607855	107.057952768928	22	0	0	0	0	0	-2	0	-3	0	-1	-2	6	4	6	-0.273049645390071	-1	0.203176742254824	-0.449786871270247	-0.968586387434555	0.663157894736842	-0.885502471169687	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.152	-1.028	9:9	146/150	F:V:L:I	3.34839479820379	4.89069202996555e-12	0.484662577645081	6.90871330415739	12.0071584873314	83.7151686983107	1.4541894385859	5.6263316435115e-18	17.2497746719749	10.8739157094292	94.2522723934353	4.32340113554558e-25	lineage4	dr_mutations_pyrazinamide	SER	SAMN07236257,SRR5710013	SRR5710013	lineage4.4.2	th	Thailand	pnca_p.leu4ser	A	E	LEU	LA4	pnca_complex.pdb
95	L4S	L2	PZA	L	L4	4	S	1	MDR	DM	hydrophobic	hydrophilic	non-polar	neutral	non-polar	polar	15.328	-1.078	-3.87	5.57838	-2.638	-3.7	63	80	-1.075	9	9	0	0	strand	3.36666666666667	8.8	0.0024435820037372	28.4570212765957	28.4570177059942	28.4308865607855	107.057952768928	22	0	0	0	0	0	-2	0	-3	0	-1	-2	6	4	6	-0.273049645390071	-1	0.203176742254824	-0.449786871270247	-0.968586387434555	0.663157894736842	-0.885502471169687	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.152	-1.028	9:9	146/150	F:V:L:I	3.34839479820379	4.89069202996555e-12	0.484662577645081	6.90871330415739	12.0071584873314	83.7151686983107	1.4541894385859	5.6263316435115e-18	17.2497746719749	10.8739157094292	94.2522723934353	4.32340113554558e-25	lineage2	dr_mutations_pyrazinamide	SER	SAMN03647142	SRR2099969	lineage2.2.1			pnca_p.leu4ser	A	E	LEU	LA4	pnca_complex.pdb
96	L4S	L2	PZA	L	L4	4	S	1	MDR	DM	hydrophobic	hydrophilic	non-polar	neutral	non-polar	polar	15.328	-1.078	-3.87	5.57838	-2.638	-3.7	63	80	-1.075	9	9	0	0	strand	3.36666666666667	8.8	0.0024435820037372	28.4570212765957	28.4570177059942	28.4308865607855	107.057952768928	22	0	0	0	0	0	-2	0	-3	0	-1	-2	6	4	6	-0.273049645390071	-1	0.203176742254824	-0.449786871270247	-0.968586387434555	0.663157894736842	-0.885502471169687	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.152	-1.028	9:9	146/150	F:V:L:I	3.34839479820379	4.89069202996555e-12	0.484662577645081	6.90871330415739	12.0071584873314	83.7151686983107	1.4541894385859	5.6263316435115e-18	17.2497746719749	10.8739157094292	94.2522723934353	4.32340113554558e-25	lineage2	dr_mutations_pyrazinamide	SER	ERR2516979	ERR2516979	lineage2.2.1	gb	UK	pnca_p.leu4ser	A	E	LEU	LA4	pnca_complex.pdb
97	L4S	L2	PZA	L	L4	4	S	1	MDR	DM	hydrophobic	hydrophilic	non-polar	neutral	non-polar	polar	15.328	-1.078	-3.87	5.57838	-2.638	-3.7	63	80	-1.075	9	9	0	0	strand	3.36666666666667	8.8	0.0024435820037372	28.4570212765957	28.4570177059942	28.4308865607855	107.057952768928	22	0	0	0	0	0	-2	0	-3	0	-1	-2	6	4	6	-0.273049645390071	-1	0.203176742254824	-0.449786871270247	-0.968586387434555	0.663157894736842	-0.885502471169687	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.152	-1.028	9:9	146/150	F:V:L:I	3.34839479820379	4.89069202996555e-12	0.484662577645081	6.90871330415739	12.0071584873314	83.7151686983107	1.4541894385859	5.6263316435115e-18	17.2497746719749	10.8739157094292	94.2522723934353	4.32340113554558e-25	lineage2	dr_mutations_pyrazinamide	SER	ERR2516927	ERR2516927	lineage2.2.1	gb	UK	pnca_p.leu4ser	A	E	LEU	LA4	pnca_complex.pdb
98	L4S	L2	PZA	L	L4	4	S	NA	MDR	DM	hydrophobic	hydrophilic	non-polar	neutral	non-polar	polar	15.328	-1.078	-3.87	5.57838	-2.638	-3.7	63	80	-1.075	9	9	0	0	strand	3.36666666666667	8.8	0.0024435820037372	28.4570212765957	28.4570177059942	28.4308865607855	107.057952768928	22	0	0	0	0	0	-2	0	-3	0	-1	-2	6	4	6	-0.273049645390071	-1	0.203176742254824	-0.449786871270247	-0.968586387434555	0.663157894736842	-0.885502471169687	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.152	-1.028	9:9	146/150	F:V:L:I	3.34839479820379	4.89069202996555e-12	0.484662577645081	6.90871330415739	12.0071584873314	83.7151686983107	1.4541894385859	5.6263316435115e-18	17.2497746719749	10.8739157094292	94.2522723934353	4.32340113554558e-25	lineage2	dr_mutations_pyrazinamide	SER	SRR6397408	SRR6397408	lineage2.2.1.1	ca	Canada	pnca_p.leu4ser	A	E	LEU	LA4	pnca_complex.pdb
99	L4S	L4	PZA	L	L4	4	S	1	MDR	DM	hydrophobic	hydrophilic	non-polar	neutral	non-polar	polar	15.328	-1.078	-3.87	5.57838	-2.638	-3.7	63	80	-1.075	9	9	0	0	strand	3.36666666666667	8.8	0.0024435820037372	28.4570212765957	28.4570177059942	28.4308865607855	107.057952768928	22	0	0	0	0	0	-2	0	-3	0	-1	-2	6	4	6	-0.273049645390071	-1	0.203176742254824	-0.449786871270247	-0.968586387434555	0.663157894736842	-0.885502471169687	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.152	-1.028	9:9	146/150	F:V:L:I	3.34839479820379	4.89069202996555e-12	0.484662577645081	6.90871330415739	12.0071584873314	83.7151686983107	1.4541894385859	5.6263316435115e-18	17.2497746719749	10.8739157094292	94.2522723934353	4.32340113554558e-25	lineage4	dr_mutations_pyrazinamide	SER	ERS2592806	ERR2677462	lineage4.2.2.1	de	Germany	pnca_p.leu4ser	A	E	LEU	LA4	pnca_complex.pdb
100	L4V	L6	PZA	L	L4	4	V	NA	MDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	15.328	-2.828	-1.717	1.19624	-1.68	-1.95	22	63	-1.075	9	9	0	0	strand	3.36666666666667	8.8	NA	NA	NA	NA	NA	22	0	0	0	0	0	0	0	-3	0	-1	-2	2	0	0	-0.716312056737589	-0.443669250645995	0.043569664697441	-0.286445012787724	-0.510471204188482	0.231578947368421	-0.885502471169687	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.152	-1.028	9:9	146/150	F:V:L:I	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	lineage6	other_mutations_pyrazinamide	VAL	ERR1215461	ERR1215461	lineage6	gh	Ghana	pnca_p.leu4val	A	E	LEU	LA4	pnca_complex.pdb
101	L4W	L2	PZA	L	L4	4	W	NA	Pre-XDR	DM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	15.328	-2.216	-2.169	1.63111	-2.168	-1.93	70	85	-1.075	9	9	0	0	strand	3.36666666666667	8.8	0.0012217910018686	22.7551797040169	22.7551786098964	22.7463684762183	46.6274188614457	-46	6	0	6	0	0	0	0	-15	0	-7	-8	0	-16	2	-0.5612968591692	-0.56046511627907	0.0594085766941776	-0.369650468883205	-0.505235602094241	0.736842105263158	-0.885502471169687	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.152	-1.028	9:9	146/150	F:V:L:I	3.12479275069714	9.15103299018708e-07	0.636534850451638	4.90906782005734	7.42096527532349	98.7712876576624	1.35708026960092	7.15795820641824e-09	8.14521084167875	6.3414443600848	123.179124931302	8.58505795592483e-12	lineage2	dr_mutations_pyrazinamide	TRP	ERR3275831	ERR3275831	lineage2.2.1	nl	Netherlands	pnca_p.leu4trp	A	E	LEU	LA4	pnca_complex.pdb
102	L4W	L1	PZA	L	L4	4	W	0	MDR	DM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	15.328	-2.216	-2.169	1.63111	-2.168	-1.93	70	85	-1.075	9	9	0	0	strand	3.36666666666667	8.8	0.0012217910018686	22.7551797040169	22.7551786098964	22.7463684762183	46.6274188614457	-46	6	0	6	0	0	0	0	-15	0	-7	-8	0	-16	2	-0.5612968591692	-0.56046511627907	0.0594085766941776	-0.369650468883205	-0.505235602094241	0.736842105263158	-0.885502471169687	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.152	-1.028	9:9	146/150	F:V:L:I	3.12479275069714	9.15103299018708e-07	0.636534850451638	4.90906782005734	7.42096527532349	98.7712876576624	1.35708026960092	7.15795820641824e-09	8.14521084167875	6.3414443600848	123.179124931302	8.58505795592483e-12	lineage1	dr_mutations_pyrazinamide	TRP	ERR2516881	ERR2516881	lineage1.1.3	gb	UK	pnca_p.leu4trp	A	E	LEU	LA4	pnca_complex.pdb
103	L4W	L4	PZA	L	L4	4	W	1	Pre-XDR	DM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	15.328	-2.216	-2.169	1.63111	-2.168	-1.93	70	85	-1.075	9	9	0	0	strand	3.36666666666667	8.8	0.0012217910018686	22.7551797040169	22.7551786098964	22.7463684762183	46.6274188614457	-46	6	0	6	0	0	0	0	-15	0	-7	-8	0	-16	2	-0.5612968591692	-0.56046511627907	0.0594085766941776	-0.369650468883205	-0.505235602094241	0.736842105263158	-0.885502471169687	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.152	-1.028	9:9	146/150	F:V:L:I	3.12479275069714	9.15103299018708e-07	0.636534850451638	4.90906782005734	7.42096527532349	98.7712876576624	1.35708026960092	7.15795820641824e-09	8.14521084167875	6.3414443600848	123.179124931302	8.58505795592483e-12	lineage4	dr_mutations_pyrazinamide	TRP	18710	ERR3014623	lineage4.1.2.1	tn	Tunisia:Bizerte	pnca_p.leu4trp	A	E	LEU	LA4	pnca_complex.pdb
104	L4W	L1	PZA	L	L4	4	W	0	MDR	DM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	15.328	-2.216	-2.169	1.63111	-2.168	-1.93	70	85	-1.075	9	9	0	0	strand	3.36666666666667	8.8	0.0012217910018686	22.7551797040169	22.7551786098964	22.7463684762183	46.6274188614457	-46	6	0	6	0	0	0	0	-15	0	-7	-8	0	-16	2	-0.5612968591692	-0.56046511627907	0.0594085766941776	-0.369650468883205	-0.505235602094241	0.736842105263158	-0.885502471169687	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.152	-1.028	9:9	146/150	F:V:L:I	3.12479275069714	9.15103299018708e-07	0.636534850451638	4.90906782005734	7.42096527532349	98.7712876576624	1.35708026960092	7.15795820641824e-09	8.14521084167875	6.3414443600848	123.179124931302	8.58505795592483e-12	lineage1	dr_mutations_pyrazinamide	TRP	ERR2516763	ERR2516763	lineage1.1.3	gb	UK	pnca_p.leu4trp	A	E	LEU	LA4	pnca_complex.pdb
105	L4W	L4	PZA	L	L4	4	W	1	MDR	DM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	15.328	-2.216	-2.169	1.63111	-2.168	-1.93	70	85	-1.075	9	9	0	0	strand	3.36666666666667	8.8	0.0012217910018686	22.7551797040169	22.7551786098964	22.7463684762183	46.6274188614457	-46	6	0	6	0	0	0	0	-15	0	-7	-8	0	-16	2	-0.5612968591692	-0.56046511627907	0.0594085766941776	-0.369650468883205	-0.505235602094241	0.736842105263158	-0.885502471169687	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.152	-1.028	9:9	146/150	F:V:L:I	3.12479275069714	9.15103299018708e-07	0.636534850451638	4.90906782005734	7.42096527532349	98.7712876576624	1.35708026960092	7.15795820641824e-09	8.14521084167875	6.3414443600848	123.179124931302	8.58505795592483e-12	lineage4	dr_mutations_pyrazinamide	TRP	13916	ERR3014609	lineage4.1.2.1	tn	Tunisia:Beja	pnca_p.leu4trp	A	E	LEU	LA4	pnca_complex.pdb
106	L4W	L2	PZA	L	L4	4	W	NA	Pre-XDR	DM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	15.328	-2.216	-2.169	1.63111	-2.168	-1.93	70	85	-1.075	9	9	0	0	strand	3.36666666666667	8.8	0.0012217910018686	22.7551797040169	22.7551786098964	22.7463684762183	46.6274188614457	-46	6	0	6	0	0	0	0	-15	0	-7	-8	0	-16	2	-0.5612968591692	-0.56046511627907	0.0594085766941776	-0.369650468883205	-0.505235602094241	0.736842105263158	-0.885502471169687	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.152	-1.028	9:9	146/150	F:V:L:I	3.12479275069714	9.15103299018708e-07	0.636534850451638	4.90906782005734	7.42096527532349	98.7712876576624	1.35708026960092	7.15795820641824e-09	8.14521084167875	6.3414443600848	123.179124931302	8.58505795592483e-12	lineage2	dr_mutations_pyrazinamide	TRP	SRS796975	SRR1723462	lineage2.2.1	cn	China:Guizhou	pnca_p.leu4trp	A	E	LEU	LA4	pnca_complex.pdb
107	L4W	L1	PZA	L	L4	4	W	NA	Pre-XDR	DM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	15.328	-2.216	-2.169	1.63111	-2.168	-1.93	70	85	-1.075	9	9	0	0	strand	3.36666666666667	8.8	0.0012217910018686	22.7551797040169	22.7551786098964	22.7463684762183	46.6274188614457	-46	6	0	6	0	0	0	0	-15	0	-7	-8	0	-16	2	-0.5612968591692	-0.56046511627907	0.0594085766941776	-0.369650468883205	-0.505235602094241	0.736842105263158	-0.885502471169687	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.152	-1.028	9:9	146/150	F:V:L:I	3.12479275069714	9.15103299018708e-07	0.636534850451638	4.90906782005734	7.42096527532349	98.7712876576624	1.35708026960092	7.15795820641824e-09	8.14521084167875	6.3414443600848	123.179124931302	8.58505795592483e-12	lineage1	dr_mutations_pyrazinamide	TRP	SRR8380866	SRR8380866	lineage1.1.2	in	India	pnca_p.leu4trp	A	E	LEU	LA4	pnca_complex.pdb
108	L4W	L2;L4	PZA	L	L4	4	W	1	Pre-XDR	DM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	15.328	-2.216	-2.169	1.63111	-2.168	-1.93	70	85	-1.075	9	9	0	0	strand	3.36666666666667	8.8	0.0012217910018686	22.7551797040169	22.7551786098964	22.7463684762183	46.6274188614457	-46	6	0	6	0	0	0	0	-15	0	-7	-8	0	-16	2	-0.5612968591692	-0.56046511627907	0.0594085766941776	-0.369650468883205	-0.505235602094241	0.736842105263158	-0.885502471169687	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.152	-1.028	9:9	146/150	F:V:L:I	3.12479275069714	9.15103299018708e-07	0.636534850451638	4.90906782005734	7.42096527532349	98.7712876576624	1.35708026960092	7.15795820641824e-09	8.14521084167875	6.3414443600848	123.179124931302	8.58505795592483e-12	lineage2;lineage4	dr_mutations_pyrazinamide	TRP	1735M-sc-2012-02-21T11:37:09Z-1364763,ERR137271	ERR137271	lineage4.2.1;lineage2.2.1	ru	Russia,Samara	pnca_p.leu4trp	A	E	LEU	LA4	pnca_complex.pdb
109	L4W	L4	PZA	L	L4	4	W	1	MDR	DM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	15.328	-2.216	-2.169	1.63111	-2.168	-1.93	70	85	-1.075	9	9	0	0	strand	3.36666666666667	8.8	0.0012217910018686	22.7551797040169	22.7551786098964	22.7463684762183	46.6274188614457	-46	6	0	6	0	0	0	0	-15	0	-7	-8	0	-16	2	-0.5612968591692	-0.56046511627907	0.0594085766941776	-0.369650468883205	-0.505235602094241	0.736842105263158	-0.885502471169687	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.152	-1.028	9:9	146/150	F:V:L:I	3.12479275069714	9.15103299018708e-07	0.636534850451638	4.90906782005734	7.42096527532349	98.7712876576624	1.35708026960092	7.15795820641824e-09	8.14521084167875	6.3414443600848	123.179124931302	8.58505795592483e-12	lineage4	dr_mutations_pyrazinamide	TRP	13878	ERR3014608	lineage4.1.2.1	tn	Tunisia:Bizerte	pnca_p.leu4trp	A	E	LEU	LA4	pnca_complex.pdb
110	L4W	L2	PZA	L	L4	4	W	1	Pre-XDR	DM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	15.328	-2.216	-2.169	1.63111	-2.168	-1.93	70	85	-1.075	9	9	0	0	strand	3.36666666666667	8.8	0.0012217910018686	22.7551797040169	22.7551786098964	22.7463684762183	46.6274188614457	-46	6	0	6	0	0	0	0	-15	0	-7	-8	0	-16	2	-0.5612968591692	-0.56046511627907	0.0594085766941776	-0.369650468883205	-0.505235602094241	0.736842105263158	-0.885502471169687	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.152	-1.028	9:9	146/150	F:V:L:I	3.12479275069714	9.15103299018708e-07	0.636534850451638	4.90906782005734	7.42096527532349	98.7712876576624	1.35708026960092	7.15795820641824e-09	8.14521084167875	6.3414443600848	123.179124931302	8.58505795592483e-12	lineage2	dr_mutations_pyrazinamide	TRP	SAMN10961363	SRR8651607	lineage2.2.1	cn	China:Wenzhou	pnca_p.leu4trp	A	E	LEU	LA4	pnca_complex.pdb
111	L4W	L2	PZA	L	L4	4	W	NA	MDR	DM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	15.328	-2.216	-2.169	1.63111	-2.168	-1.93	70	85	-1.075	9	9	0	0	strand	3.36666666666667	8.8	0.0012217910018686	22.7551797040169	22.7551786098964	22.7463684762183	46.6274188614457	-46	6	0	6	0	0	0	0	-15	0	-7	-8	0	-16	2	-0.5612968591692	-0.56046511627907	0.0594085766941776	-0.369650468883205	-0.505235602094241	0.736842105263158	-0.885502471169687	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.152	-1.028	9:9	146/150	F:V:L:I	3.12479275069714	9.15103299018708e-07	0.636534850451638	4.90906782005734	7.42096527532349	98.7712876576624	1.35708026960092	7.15795820641824e-09	8.14521084167875	6.3414443600848	123.179124931302	8.58505795592483e-12	lineage2	dr_mutations_pyrazinamide	TRP	ERR137236,1477G-sc-2012-02-21T11:36:45Z-1364728	ERR137236	lineage2.2.1	ru	Russia	pnca_p.leu4trp	A	E	LEU	LA4	pnca_complex.pdb
112	L4W	L2	PZA	L	L4	4	W	NA	XDR	DM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	15.328	-2.216	-2.169	1.63111	-2.168	-1.93	70	85	-1.075	9	9	0	0	strand	3.36666666666667	8.8	0.0012217910018686	22.7551797040169	22.7551786098964	22.7463684762183	46.6274188614457	-46	6	0	6	0	0	0	0	-15	0	-7	-8	0	-16	2	-0.5612968591692	-0.56046511627907	0.0594085766941776	-0.369650468883205	-0.505235602094241	0.736842105263158	-0.885502471169687	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.152	-1.028	9:9	146/150	F:V:L:I	3.12479275069714	9.15103299018708e-07	0.636534850451638	4.90906782005734	7.42096527532349	98.7712876576624	1.35708026960092	7.15795820641824e-09	8.14521084167875	6.3414443600848	123.179124931302	8.58505795592483e-12	lineage2	dr_mutations_pyrazinamide	TRP	SAMN02398703	SRR1144796_SRR1047989	lineage2.2.2	kr	South Korea	pnca_p.leu4trp	A	E	LEU	LA4	pnca_complex.pdb
113	L4W	L2	PZA	L	L4	4	W	1	XDR	DM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	15.328	-2.216	-2.169	1.63111	-2.168	-1.93	70	85	-1.075	9	9	0	0	strand	3.36666666666667	8.8	0.0012217910018686	22.7551797040169	22.7551786098964	22.7463684762183	46.6274188614457	-46	6	0	6	0	0	0	0	-15	0	-7	-8	0	-16	2	-0.5612968591692	-0.56046511627907	0.0594085766941776	-0.369650468883205	-0.505235602094241	0.736842105263158	-0.885502471169687	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.152	-1.028	9:9	146/150	F:V:L:I	3.12479275069714	9.15103299018708e-07	0.636534850451638	4.90906782005734	7.42096527532349	98.7712876576624	1.35708026960092	7.15795820641824e-09	8.14521084167875	6.3414443600848	123.179124931302	8.58505795592483e-12	lineage2	dr_mutations_pyrazinamide	TRP	SAMN10961353	SRR8651594	lineage2.2.1	cn	China:Wenzhou	pnca_p.leu4trp	A	E	LEU	LA4	pnca_complex.pdb
114	L4W	L2	PZA	L	L4	4	W	1	Pre-XDR	DM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	15.328	-2.216	-2.169	1.63111	-2.168	-1.93	70	85	-1.075	9	9	0	0	strand	3.36666666666667	8.8	0.0012217910018686	22.7551797040169	22.7551786098964	22.7463684762183	46.6274188614457	-46	6	0	6	0	0	0	0	-15	0	-7	-8	0	-16	2	-0.5612968591692	-0.56046511627907	0.0594085766941776	-0.369650468883205	-0.505235602094241	0.736842105263158	-0.885502471169687	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.152	-1.028	9:9	146/150	F:V:L:I	3.12479275069714	9.15103299018708e-07	0.636534850451638	4.90906782005734	7.42096527532349	98.7712876576624	1.35708026960092	7.15795820641824e-09	8.14521084167875	6.3414443600848	123.179124931302	8.58505795592483e-12	lineage2	dr_mutations_pyrazinamide	TRP	MDR_24272	SRR6824542	lineage2.2.1	cn	China: Bijie City, Guizhou Province	pnca_p.leu4trp	A	E	LEU	LA4	pnca_complex.pdb
115	L4W	L2	PZA	L	L4	4	W	NA	XDR	DM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	15.328	-2.216	-2.169	1.63111	-2.168	-1.93	70	85	-1.075	9	9	0	0	strand	3.36666666666667	8.8	0.0012217910018686	22.7551797040169	22.7551786098964	22.7463684762183	46.6274188614457	-46	6	0	6	0	0	0	0	-15	0	-7	-8	0	-16	2	-0.5612968591692	-0.56046511627907	0.0594085766941776	-0.369650468883205	-0.505235602094241	0.736842105263158	-0.885502471169687	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.152	-1.028	9:9	146/150	F:V:L:I	3.12479275069714	9.15103299018708e-07	0.636534850451638	4.90906782005734	7.42096527532349	98.7712876576624	1.35708026960092	7.15795820641824e-09	8.14521084167875	6.3414443600848	123.179124931302	8.58505795592483e-12	lineage2	dr_mutations_pyrazinamide	TRP	SAMN07236540,SRR5710028	SRR5710028	lineage2.2.1	th	Thailand	pnca_p.leu4trp	A	E	LEU	LA4	pnca_complex.pdb
116	L4W	L2	PZA	L	L4	4	W	1	Pre-XDR	DM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	15.328	-2.216	-2.169	1.63111	-2.168	-1.93	70	85	-1.075	9	9	0	0	strand	3.36666666666667	8.8	0.0012217910018686	22.7551797040169	22.7551786098964	22.7463684762183	46.6274188614457	-46	6	0	6	0	0	0	0	-15	0	-7	-8	0	-16	2	-0.5612968591692	-0.56046511627907	0.0594085766941776	-0.369650468883205	-0.505235602094241	0.736842105263158	-0.885502471169687	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.152	-1.028	9:9	146/150	F:V:L:I	3.12479275069714	9.15103299018708e-07	0.636534850451638	4.90906782005734	7.42096527532349	98.7712876576624	1.35708026960092	7.15795820641824e-09	8.14521084167875	6.3414443600848	123.179124931302	8.58505795592483e-12	lineage2	dr_mutations_pyrazinamide	TRP	SAMN10961319	SRR8651646	lineage2.2.1	cn	China:Wenzhou	pnca_p.leu4trp	A	E	LEU	LA4	pnca_complex.pdb
117	L4W	L4	PZA	L	L4	4	W	1	MDR	DM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	15.328	-2.216	-2.169	1.63111	-2.168	-1.93	70	85	-1.075	9	9	0	0	strand	3.36666666666667	8.8	0.0012217910018686	22.7551797040169	22.7551786098964	22.7463684762183	46.6274188614457	-46	6	0	6	0	0	0	0	-15	0	-7	-8	0	-16	2	-0.5612968591692	-0.56046511627907	0.0594085766941776	-0.369650468883205	-0.505235602094241	0.736842105263158	-0.885502471169687	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.152	-1.028	9:9	146/150	F:V:L:I	3.12479275069714	9.15103299018708e-07	0.636534850451638	4.90906782005734	7.42096527532349	98.7712876576624	1.35708026960092	7.15795820641824e-09	8.14521084167875	6.3414443600848	123.179124931302	8.58505795592483e-12	lineage4	dr_mutations_pyrazinamide	TRP	19367	ERR3014625	lineage4.1.2.1	tn	Tunisia:Tunis	pnca_p.leu4trp	A	E	LEU	LA4	pnca_complex.pdb
118	L4W	L2	PZA	L	L4	4	W	1	Pre-XDR	DM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	15.328	-2.216	-2.169	1.63111	-2.168	-1.93	70	85	-1.075	9	9	0	0	strand	3.36666666666667	8.8	0.0012217910018686	22.7551797040169	22.7551786098964	22.7463684762183	46.6274188614457	-46	6	0	6	0	0	0	0	-15	0	-7	-8	0	-16	2	-0.5612968591692	-0.56046511627907	0.0594085766941776	-0.369650468883205	-0.505235602094241	0.736842105263158	-0.885502471169687	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.152	-1.028	9:9	146/150	F:V:L:I	3.12479275069714	9.15103299018708e-07	0.636534850451638	4.90906782005734	7.42096527532349	98.7712876576624	1.35708026960092	7.15795820641824e-09	8.14521084167875	6.3414443600848	123.179124931302	8.58505795592483e-12	lineage2	dr_mutations_pyrazinamide	TRP	SAMN10961329	SRR8651661	lineage2.2.1	cn	China:Wenzhou	pnca_p.leu4trp	A	E	LEU	LA4	pnca_complex.pdb
119	L4W	L3	PZA	L	L4	4	W	1	MDR	DM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	15.328	-2.216	-2.169	1.63111	-2.168	-1.93	70	85	-1.075	9	9	0	0	strand	3.36666666666667	8.8	0.0012217910018686	22.7551797040169	22.7551786098964	22.7463684762183	46.6274188614457	-46	6	0	6	0	0	0	0	-15	0	-7	-8	0	-16	2	-0.5612968591692	-0.56046511627907	0.0594085766941776	-0.369650468883205	-0.505235602094241	0.736842105263158	-0.885502471169687	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.152	-1.028	9:9	146/150	F:V:L:I	3.12479275069714	9.15103299018708e-07	0.636534850451638	4.90906782005734	7.42096527532349	98.7712876576624	1.35708026960092	7.15795820641824e-09	8.14521084167875	6.3414443600848	123.179124931302	8.58505795592483e-12	lineage3	dr_mutations_pyrazinamide	TRP	ERR2510522	ERR2510522	lineage3	pk	Pakistan	pnca_p.leu4trp	A	E	LEU	LA4	pnca_complex.pdb
120	L4W	L4	PZA	L	L4	4	W	1	MDR	DM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	15.328	-2.216	-2.169	1.63111	-2.168	-1.93	70	85	-1.075	9	9	0	0	strand	3.36666666666667	8.8	0.0012217910018686	22.7551797040169	22.7551786098964	22.7463684762183	46.6274188614457	-46	6	0	6	0	0	0	0	-15	0	-7	-8	0	-16	2	-0.5612968591692	-0.56046511627907	0.0594085766941776	-0.369650468883205	-0.505235602094241	0.736842105263158	-0.885502471169687	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.152	-1.028	9:9	146/150	F:V:L:I	3.12479275069714	9.15103299018708e-07	0.636534850451638	4.90906782005734	7.42096527532349	98.7712876576624	1.35708026960092	7.15795820641824e-09	8.14521084167875	6.3414443600848	123.179124931302	8.58505795592483e-12	lineage4	dr_mutations_pyrazinamide	TRP	18013	ERR3014620	lineage4.1.2.1	tn	Tunisia:Sousse	pnca_p.leu4trp	A	E	LEU	LA4	pnca_complex.pdb
121	L4W	L1	PZA	L	L4	4	W	0	MDR	DM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	15.328	-2.216	-2.169	1.63111	-2.168	-1.93	70	85	-1.075	9	9	0	0	strand	3.36666666666667	8.8	0.0012217910018686	22.7551797040169	22.7551786098964	22.7463684762183	46.6274188614457	-46	6	0	6	0	0	0	0	-15	0	-7	-8	0	-16	2	-0.5612968591692	-0.56046511627907	0.0594085766941776	-0.369650468883205	-0.505235602094241	0.736842105263158	-0.885502471169687	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.152	-1.028	9:9	146/150	F:V:L:I	3.12479275069714	9.15103299018708e-07	0.636534850451638	4.90906782005734	7.42096527532349	98.7712876576624	1.35708026960092	7.15795820641824e-09	8.14521084167875	6.3414443600848	123.179124931302	8.58505795592483e-12	lineage1	dr_mutations_pyrazinamide	TRP	ERR2516833	ERR2516833	lineage1.1.3	gb	UK	pnca_p.leu4trp	A	E	LEU	LA4	pnca_complex.pdb
122	L4W	L4	PZA	L	L4	4	W	1	MDR	DM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	15.328	-2.216	-2.169	1.63111	-2.168	-1.93	70	85	-1.075	9	9	0	0	strand	3.36666666666667	8.8	0.0012217910018686	22.7551797040169	22.7551786098964	22.7463684762183	46.6274188614457	-46	6	0	6	0	0	0	0	-15	0	-7	-8	0	-16	2	-0.5612968591692	-0.56046511627907	0.0594085766941776	-0.369650468883205	-0.505235602094241	0.736842105263158	-0.885502471169687	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.152	-1.028	9:9	146/150	F:V:L:I	3.12479275069714	9.15103299018708e-07	0.636534850451638	4.90906782005734	7.42096527532349	98.7712876576624	1.35708026960092	7.15795820641824e-09	8.14521084167875	6.3414443600848	123.179124931302	8.58505795592483e-12	lineage4	dr_mutations_pyrazinamide	TRP	2666	ERR3014584	lineage4.1.2.1	tn	Tunisia:Sousse	pnca_p.leu4trp	A	E	LEU	LA4	pnca_complex.pdb
123	L4W	L2	PZA	L	L4	4	W	NA	Pre-XDR	DM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	15.328	-2.216	-2.169	1.63111	-2.168	-1.93	70	85	-1.075	9	9	0	0	strand	3.36666666666667	8.8	0.0012217910018686	22.7551797040169	22.7551786098964	22.7463684762183	46.6274188614457	-46	6	0	6	0	0	0	0	-15	0	-7	-8	0	-16	2	-0.5612968591692	-0.56046511627907	0.0594085766941776	-0.369650468883205	-0.505235602094241	0.736842105263158	-0.885502471169687	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.152	-1.028	9:9	146/150	F:V:L:I	3.12479275069714	9.15103299018708e-07	0.636534850451638	4.90906782005734	7.42096527532349	98.7712876576624	1.35708026960092	7.15795820641824e-09	8.14521084167875	6.3414443600848	123.179124931302	8.58505795592483e-12	lineage2	dr_mutations_pyrazinamide	TRP	SRR5710014,SAMN07236287	SRR5710014	lineage2.2.1	th	Thailand	pnca_p.leu4trp	A	E	LEU	LA4	pnca_complex.pdb
124	L4W	L4	PZA	L	L4	4	W	1	MDR	DM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	15.328	-2.216	-2.169	1.63111	-2.168	-1.93	70	85	-1.075	9	9	0	0	strand	3.36666666666667	8.8	0.0012217910018686	22.7551797040169	22.7551786098964	22.7463684762183	46.6274188614457	-46	6	0	6	0	0	0	0	-15	0	-7	-8	0	-16	2	-0.5612968591692	-0.56046511627907	0.0594085766941776	-0.369650468883205	-0.505235602094241	0.736842105263158	-0.885502471169687	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.152	-1.028	9:9	146/150	F:V:L:I	3.12479275069714	9.15103299018708e-07	0.636534850451638	4.90906782005734	7.42096527532349	98.7712876576624	1.35708026960092	7.15795820641824e-09	8.14521084167875	6.3414443600848	123.179124931302	8.58505795592483e-12	lineage4	dr_mutations_pyrazinamide	TRP	16260	ERR3014615	lineage4.1.2.1	tn	Tunisia:Nabeul	pnca_p.leu4trp	A	E	LEU	LA4	pnca_complex.pdb
125	I5S	L4	PZA	I	I5	5	S	NA	MDR	DM	hydrophobic	hydrophilic	non-polar	neutral	non-polar	polar	11.437	-0.778	-3.843	5.83176	-3.518	-3.58	63	80	-0.011	5	5	0	0	strand	4.26666666666667	12.6	7.18700589334483e-05	9.70142977291842	188179.92626441	Inf	0.763784339928386	30	0	0	0	0	0	-4	0	4	0	2	2	0	4	0	-0.197061803444782	-0.993023255813954	0.212405393395931	-0.599829497016198	-0.93717277486911	0.663157894736842	-0.00906095551894563	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.244	0.083	6:5	146/150	G:F:I:L:V	12.1451538387253	0.919026337424193	119.46804443616	0.101660271548307	5.0115366606943e-06	NA	0.986835744238421	0.170978870202674	0.767057556984365	0.124324963210678	Inf	0.382146811758261	lineage4	dr_mutations_pyrazinamide	SER	ERR2179669	ERR2179669	lineage4.4	cn	China	pnca_p.ile5ser	A	E	ILE	IA5	pnca_complex.pdb
126	I5S	L4	PZA	I	I5	5	S	NA	MDR	DM	hydrophobic	hydrophilic	non-polar	neutral	non-polar	polar	11.437	-0.778	-3.843	5.83176	-3.518	-3.58	63	80	-0.011	5	5	0	0	strand	4.26666666666667	12.6	7.18700589334483e-05	9.70142977291842	188179.92626441	Inf	0.763784339928386	30	0	0	0	0	0	-4	0	4	0	2	2	0	4	0	-0.197061803444782	-0.993023255813954	0.212405393395931	-0.599829497016198	-0.93717277486911	0.663157894736842	-0.00906095551894563	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.244	0.083	6:5	146/150	G:F:I:L:V	12.1451538387253	0.919026337424193	119.46804443616	0.101660271548307	5.0115366606943e-06	NA	0.986835744238421	0.170978870202674	0.767057556984365	0.124324963210678	Inf	0.382146811758261	lineage4	dr_mutations_pyrazinamide	SER	ERR502939	ERR502939	lineage4.4			pnca_p.ile5ser	A	E	ILE	IA5	pnca_complex.pdb
127	I5S	L4	PZA	I	I5	5	S	NA	MDR	DM	hydrophobic	hydrophilic	non-polar	neutral	non-polar	polar	11.437	-0.778	-3.843	5.83176	-3.518	-3.58	63	80	-0.011	5	5	0	0	strand	4.26666666666667	12.6	7.18700589334483e-05	9.70142977291842	188179.92626441	Inf	0.763784339928386	30	0	0	0	0	0	-4	0	4	0	2	2	0	4	0	-0.197061803444782	-0.993023255813954	0.212405393395931	-0.599829497016198	-0.93717277486911	0.663157894736842	-0.00906095551894563	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.244	0.083	6:5	146/150	G:F:I:L:V	12.1451538387253	0.919026337424193	119.46804443616	0.101660271548307	5.0115366606943e-06	NA	0.986835744238421	0.170978870202674	0.767057556984365	0.124324963210678	Inf	0.382146811758261	lineage4	dr_mutations_pyrazinamide	SER	SRS797458	SRR1723998	lineage4.4	cn	China:Hunan	pnca_p.ile5ser	A	E	ILE	IA5	pnca_complex.pdb
128	I5S	L2	PZA	I	I5	5	S	NA	Pre-XDR	DM	hydrophobic	hydrophilic	non-polar	neutral	non-polar	polar	11.437	-0.778	-3.843	5.83176	-3.518	-3.58	63	80	-0.011	5	5	0	0	strand	4.26666666666667	12.6	7.18700589334483e-05	9.70142977291842	188179.92626441	Inf	0.763784339928386	30	0	0	0	0	0	-4	0	4	0	2	2	0	4	0	-0.197061803444782	-0.993023255813954	0.212405393395931	-0.599829497016198	-0.93717277486911	0.663157894736842	-0.00906095551894563	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.244	0.083	6:5	146/150	G:F:I:L:V	12.1451538387253	0.919026337424193	119.46804443616	0.101660271548307	5.0115366606943e-06	NA	0.986835744238421	0.170978870202674	0.767057556984365	0.124324963210678	Inf	0.382146811758261	lineage2	dr_mutations_pyrazinamide	SER	ERR751650	ERR751650	lineage2.2.1	th	Thailand	pnca_p.ile5ser	A	E	ILE	IA5	pnca_complex.pdb
129	I5S	L4	PZA	I	I5	5	S	1	MDR	DM	hydrophobic	hydrophilic	non-polar	neutral	non-polar	polar	11.437	-0.778	-3.843	5.83176	-3.518	-3.58	63	80	-0.011	5	5	0	0	strand	4.26666666666667	12.6	7.18700589334483e-05	9.70142977291842	188179.92626441	Inf	0.763784339928386	30	0	0	0	0	0	-4	0	4	0	2	2	0	4	0	-0.197061803444782	-0.993023255813954	0.212405393395931	-0.599829497016198	-0.93717277486911	0.663157894736842	-0.00906095551894563	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.244	0.083	6:5	146/150	G:F:I:L:V	12.1451538387253	0.919026337424193	119.46804443616	0.101660271548307	5.0115366606943e-06	NA	0.986835744238421	0.170978870202674	0.767057556984365	0.124324963210678	Inf	0.382146811758261	lineage4	dr_mutations_pyrazinamide	SER	MDR_18568	SRR6824524	lineage4.4	cn	China: Leiyang City, Hengyang City, Hunan Province	pnca_p.ile5ser	A	E	ILE	IA5	pnca_complex.pdb
130	I5S	L2	PZA	I	I5	5	S	NA	XDR	DM	hydrophobic	hydrophilic	non-polar	neutral	non-polar	polar	11.437	-0.778	-3.843	5.83176	-3.518	-3.58	63	80	-0.011	5	5	0	0	strand	4.26666666666667	12.6	7.18700589334483e-05	9.70142977291842	188179.92626441	Inf	0.763784339928386	30	0	0	0	0	0	-4	0	4	0	2	2	0	4	0	-0.197061803444782	-0.993023255813954	0.212405393395931	-0.599829497016198	-0.93717277486911	0.663157894736842	-0.00906095551894563	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.244	0.083	6:5	146/150	G:F:I:L:V	12.1451538387253	0.919026337424193	119.46804443616	0.101660271548307	5.0115366606943e-06	NA	0.986835744238421	0.170978870202674	0.767057556984365	0.124324963210678	Inf	0.382146811758261	lineage2	dr_mutations_pyrazinamide	SER	SRR8380939	SRR8380939	lineage2.2.1	in	India	pnca_p.ile5ser	A	E	ILE	IA5	pnca_complex.pdb
131	I5T	L1	PZA	I	I5	5	T	1	MDR	DM	hydrophobic	hydrophobic	non-polar	neutral	non-polar	polar	11.437	-0.945	-3.43	3.67776	-2.709	-3.3	63	80	-0.011	5	5	0	0	strand	4.26666666666667	12.6	0.0002874802357337	14.5631313131313	14.5630810302278	14.5631012253236	5.81873994206135	32	0	0	0	0	0	-4	0	4	0	2	2	0	4	0	-0.23936170212766	-0.886304909560723	0.133952024708805	-0.461892583120205	-0.863874345549738	0.663157894736842	-0.00906095551894563	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.244	0.083	6:5	146/150	G:F:I:L:V	2.67848962960141	0.0202679102821362	1.15384949648317	2.3213509541454	1.86363317860697	294.488177946116	1.16325476548539	0.0174140488202037	1.75910024233227	1.16837785201846	760.989759542733	0.0158563003544608	lineage1	dr_mutations_pyrazinamide	THR	ERR2510512	ERR2510512	lineage1.2.2	pk	Pakistan	pnca_p.ile5thr	A	E	ILE	IA5	pnca_complex.pdb
132	I5T	L4	PZA	I	I5	5	T	0	XDR	DM	hydrophobic	hydrophobic	non-polar	neutral	non-polar	polar	11.437	-0.945	-3.43	3.67776	-2.709	-3.3	63	80	-0.011	5	5	0	0	strand	4.26666666666667	12.6	0.0002874802357337	14.5631313131313	14.5630810302278	14.5631012253236	5.81873994206135	32	0	0	0	0	0	-4	0	4	0	2	2	0	4	0	-0.23936170212766	-0.886304909560723	0.133952024708805	-0.461892583120205	-0.863874345549738	0.663157894736842	-0.00906095551894563	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.244	0.083	6:5	146/150	G:F:I:L:V	2.67848962960141	0.0202679102821362	1.15384949648317	2.3213509541454	1.86363317860697	294.488177946116	1.16325476548539	0.0174140488202037	1.75910024233227	1.16837785201846	760.989759542733	0.0158563003544608	lineage4	dr_mutations_pyrazinamide	THR	ERR2041730	ERR2041730	lineage4.8	rs	Serbia	pnca_p.ile5thr	A	E	ILE	IA5	pnca_complex.pdb
133	I5T	L1	PZA	I	I5	5	T	NA	MDR	DM	hydrophobic	hydrophobic	non-polar	neutral	non-polar	polar	11.437	-0.945	-3.43	3.67776	-2.709	-3.3	63	80	-0.011	5	5	0	0	strand	4.26666666666667	12.6	0.0002874802357337	14.5631313131313	14.5630810302278	14.5631012253236	5.81873994206135	32	0	0	0	0	0	-4	0	4	0	2	2	0	4	0	-0.23936170212766	-0.886304909560723	0.133952024708805	-0.461892583120205	-0.863874345549738	0.663157894736842	-0.00906095551894563	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.244	0.083	6:5	146/150	G:F:I:L:V	2.67848962960141	0.0202679102821362	1.15384949648317	2.3213509541454	1.86363317860697	294.488177946116	1.16325476548539	0.0174140488202037	1.75910024233227	1.16837785201846	760.989759542733	0.0158563003544608	lineage1	dr_mutations_pyrazinamide	THR	SAMN02599179	SRR1172873_SRR1172848	lineage1.1.2	in	India	pnca_p.ile5thr	A	E	ILE	IA5	pnca_complex.pdb
134	I5T	L2	PZA	I	I5	5	T	1	Pre-XDR	DM	hydrophobic	hydrophobic	non-polar	neutral	non-polar	polar	11.437	-0.945	-3.43	3.67776	-2.709	-3.3	63	80	-0.011	5	5	0	0	strand	4.26666666666667	12.6	0.0002874802357337	14.5631313131313	14.5630810302278	14.5631012253236	5.81873994206135	32	0	0	0	0	0	-4	0	4	0	2	2	0	4	0	-0.23936170212766	-0.886304909560723	0.133952024708805	-0.461892583120205	-0.863874345549738	0.663157894736842	-0.00906095551894563	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.244	0.083	6:5	146/150	G:F:I:L:V	2.67848962960141	0.0202679102821362	1.15384949648317	2.3213509541454	1.86363317860697	294.488177946116	1.16325476548539	0.0174140488202037	1.75910024233227	1.16837785201846	760.989759542733	0.0158563003544608	lineage2	dr_mutations_pyrazinamide	THR	SAMN10961352	SRR8651582	lineage2.2.1	cn	China:Wenzhou	pnca_p.ile5thr	A	E	ILE	IA5	pnca_complex.pdb
135	I5T	L4	PZA	I	I5	5	T	NA	MDR	DM	hydrophobic	hydrophobic	non-polar	neutral	non-polar	polar	11.437	-0.945	-3.43	3.67776	-2.709	-3.3	63	80	-0.011	5	5	0	0	strand	4.26666666666667	12.6	0.0002874802357337	14.5631313131313	14.5630810302278	14.5631012253236	5.81873994206135	32	0	0	0	0	0	-4	0	4	0	2	2	0	4	0	-0.23936170212766	-0.886304909560723	0.133952024708805	-0.461892583120205	-0.863874345549738	0.663157894736842	-0.00906095551894563	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.244	0.083	6:5	146/150	G:F:I:L:V	2.67848962960141	0.0202679102821362	1.15384949648317	2.3213509541454	1.86363317860697	294.488177946116	1.16325476548539	0.0174140488202037	1.75910024233227	1.16837785201846	760.989759542733	0.0158563003544608	lineage4	dr_mutations_pyrazinamide	THR	ERR779880	ERR779880	lineage4.3.4.2	pe		pnca_p.ile5thr	A	E	ILE	IA5	pnca_complex.pdb
136	I5T	L4	PZA	I	I5	5	T	1	MDR	DM	hydrophobic	hydrophobic	non-polar	neutral	non-polar	polar	11.437	-0.945	-3.43	3.67776	-2.709	-3.3	63	80	-0.011	5	5	0	0	strand	4.26666666666667	12.6	0.0002874802357337	14.5631313131313	14.5630810302278	14.5631012253236	5.81873994206135	32	0	0	0	0	0	-4	0	4	0	2	2	0	4	0	-0.23936170212766	-0.886304909560723	0.133952024708805	-0.461892583120205	-0.863874345549738	0.663157894736842	-0.00906095551894563	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.244	0.083	6:5	146/150	G:F:I:L:V	2.67848962960141	0.0202679102821362	1.15384949648317	2.3213509541454	1.86363317860697	294.488177946116	1.16325476548539	0.0174140488202037	1.75910024233227	1.16837785201846	760.989759542733	0.0158563003544608	lineage4	dr_mutations_pyrazinamide	THR	ERR551126,ERS457122,4148-04	ERR551126	lineage4.1.2.1			pnca_p.ile5thr	A	E	ILE	IA5	pnca_complex.pdb
137	I6L	L2	PZA	I	I6	6	L	NA	Pre-XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	ERR067611,0341X-sc-2011-09-07T13:19:07Z-1276458	ERR067611	lineage2.2.1	ru	Russia	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
138	I6L	L2	PZA	I	I6	6	L	0	Pre-XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	ERR133839,0293V-sc-2012-02-09T18:55:51Z-1355172	ERR133839	lineage2.2.1	ru	Russia,Samara	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
139	I6L	L2	PZA	I	I6	6	L	0	Pre-XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	ERR144633,2073E-sc-2012-02-21T11:38:30Z-1364871	ERR144633	lineage2.2.1	ru	Russia,Samara	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
140	I6L	L2	PZA	I	I6	6	L	0	Pre-XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	ERR133902,0669D-sc-2012-02-09T18:56:41Z-1355235	ERR133902	lineage2.2.1	ru	Russia,Samara	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
141	I6L	L2	PZA	I	I6	6	L	1	Pre-XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	1409H-sc-2012-02-21T11:36:37Z-1364717,ERR137225	ERR137225	lineage2.2.1	ru	Russia,Samara	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
142	I6L	L2	PZA	I	I6	6	L	0	Pre-XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	ERR067721,0188F-sc-2011-08-25T12:38:23Z-1262320	ERR067721	lineage2.2.1	ru	Russia,Samara	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
143	I6L	L2	PZA	I	I6	6	L	NA	Pre-XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	1239Y-sc-2011-09-07T13:20:01Z-1276545,ERR067698	ERR067698	lineage2.2.1	ru	Russia	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
144	I6L	L2	PZA	I	I6	6	L	1	Pre-XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	0696H-sc-2012-02-09T18:56:44Z-1355239,ERR133906	ERR133906	lineage2.2.1	ru	Russia,Samara	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
145	I6L	L2	PZA	I	I6	6	L	0	XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	ERR234598,0322B-sc-2012-10-11T13:36:31Z-1494084	ERR234598	lineage2.2.1	ru	Russia,Samara	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
146	I6L	L2	PZA	I	I6	6	L	0	XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	ERR144551,1802K-sc-2012-02-21T11:37:27Z-1364788	ERR144551	lineage2.2.1	ru	Russia,Samara	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
147	I6L	L2	PZA	I	I6	6	L	0	Pre-XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	0405R-sc-2012-02-09T18:56:06Z-1355193,ERR133860	ERR133860	lineage2.2.1	ru	Russia,Samara	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
148	I6L	L2	PZA	I	I6	6	L	0	Pre-XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	2335P-sc-2012-10-11T13:38:47Z-1494225,ERR228061	ERR228061	lineage2.2.1	ru	Russia,Samara	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
149	I6L	L2	PZA	I	I6	6	L	0	Pre-XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	0406S-sc-2011-08-25T12:38:37Z-1262341,ERR067742	ERR067742	lineage2.2.1	ru	Russia,Samara	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
150	I6L	L2	PZA	I	I6	6	L	0	Pre-XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	ERR133959,0869W-sc-2012-02-09T18:57:22Z-1355292	ERR133959	lineage2.2.1	ru	Russia,Samara	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
151	I6L	L2;L4	PZA	I	I6	6	L	0	Pre-XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2;lineage4	other_mutations_pyrazinamide	LEU	1815Z-sc-2012-02-21T11:37:31Z-1364793,ERR144556	ERR144556	lineage4;lineage2.2.1	ru	Russia,Samara	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
152	I6L	L2	PZA	I	I6	6	L	NA	XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	ERR144591	ERR144591	lineage2.2.1	ru	Russia	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
153	I6L	L2	PZA	I	I6	6	L	0	Pre-XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	0367A-sc-2011-09-07T13:19:59Z-1276542,ERR067695	ERR067695	lineage2.2.1	ru	Russia,Samara	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
154	I6L	L2	PZA	I	I6	6	L	0	Pre-XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	2140C-sc-2012-04-10T09:16:23Z-1397804,ERR158592	ERR158592	lineage2.2.1	ru	Russia,Samara	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
155	I6L	L2	PZA	I	I6	6	L	0	Pre-XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	0458Z-sc-2012-02-09T18:56:10Z-1355199,ERR133866	ERR133866	lineage2.2.1	ru	Russia,Samara	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
156	I6L	L2	PZA	I	I6	6	L	0	Pre-XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	2325D-sc-2012-10-11T13:38:01Z-1494177,ERR228013	ERR228013	lineage2.2.1	ru	Russia,Samara	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
157	I6L	L2	PZA	I	I6	6	L	NA	Pre-XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	ERR137237,1502J-sc-2012-02-21T11:36:46Z-1364729	ERR137237	lineage2.2.1	ru	Russia	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
158	I6L	L2	PZA	I	I6	6	L	0	Pre-XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	ERR228029,2327F-sc-2012-10-11T13:38:16Z-1494193	ERR228029	lineage2.2.1	ru	Russia,Samara	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
159	I6L	L2	PZA	I	I6	6	L	0	Pre-XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	0664Y-sc-2012-10-11T13:36:35Z-1494088,ERR234602	ERR234602	lineage2.2.1	ru	Russia	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
160	I6L	L2	PZA	I	I6	6	L	0	Pre-XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	ERR108493,1126A-sc-2011-10-12T14:59:23Z-1289158	ERR108493	lineage2.2.1	ru	Russia,Samara	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
161	I6L	L2	PZA	I	I6	6	L	0	Pre-XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	0556F-sc-2012-02-09T18:56:24Z-1355218,ERR133885	ERR133885	lineage2.2.1	ru	Russia,Samara	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
162	I6L	L2	PZA	I	I6	6	L	0	Pre-XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	ERR144561,1824J-sc-2012-02-21T11:37:34Z-1364798	ERR144561	lineage2.2.1	ru	Russia,Samara	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
163	I6L	L2	PZA	I	I6	6	L	0	Pre-XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	ERR229966,2393C-sc-2012-10-11T13:39:45Z-1494285	ERR229966	lineage2.2.1	ru	Russia,Samara	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
164	I6L	L2	PZA	I	I6	6	L	0	Pre-XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	0915W-sc-2011-09-07T13:19:46Z-1276520,ERR067673	ERR067673	lineage2.2.1	ru	Russia,Samara	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
165	I6L	L2	PZA	I	I6	6	L	NA	Pre-XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	ERR230009	ERR230009	lineage2.2.1	ru	Russia	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
166	I6L	L2	PZA	I	I6	6	L	NA	Pre-XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	ERR137226	ERR137226	lineage2.2.1	ru	Russia	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
167	I6L	L2	PZA	I	I6	6	L	0	Pre-XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	ERR067758,0508D-sc-2011-08-25T12:38:45Z-1262357	ERR067758	lineage2.2.1	ru	Russia,Samara	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
168	I6L	L2	PZA	I	I6	6	L	NA	Pre-XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	ERR144615,2020X-sc-2012-02-21T11:38:18Z-1364852	ERR144615	lineage2.2.1	ru	Russia	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
169	I6L	L2	PZA	I	I6	6	L	0	XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	0389Z-sc-2012-02-09T18:56:02Z-1355187,ERR133854	ERR133854	lineage2.2.1	ru	Russia,Samara	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
170	I6L	L2	PZA	I	I6	6	L	0	Pre-XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	ERR108473,0967C-sc-2011-10-12T14:59:08Z-1289138	ERR108473	lineage2.2.1	ru	Russia,Samara	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
171	I6L	L2	PZA	I	I6	6	L	0	Pre-XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	0761D-sc-2011-10-12T14:59:04Z-1289132,ERR108467	ERR108467	lineage2.2.1	ru	Russia,Samara	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
172	I6L	L2	PZA	I	I6	6	L	0	XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	ERR234653,2525W-sc-2012-10-11T13:40:29Z-1494331	ERR234653	lineage2.2.1	ru	Russia,Samara	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
173	I6L	L2	PZA	I	I6	6	L	0	XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	ERR234596,0040V-sc-2012-10-11T13:36:29Z-1494082	ERR234596	lineage2.2.1	ru	Russia,Samara	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
174	I6L	L2	PZA	I	I6	6	L	0	Pre-XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	2491J-sc-2012-10-11T13:39:02Z-1494240,ERR229921	ERR229921	lineage2.2.1	ru	Russia,Samara	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
175	I6L	L2	PZA	I	I6	6	L	1	XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	0514K-sc-2011-09-07T13:18:57Z-1276439,ERR067592	ERR067592	lineage2.2.1	ru	Russia,Samara	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
176	I6L	L2	PZA	I	I6	6	L	0	Pre-XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	ERR234595,1355Z-sc-2012-10-11T13:36:28Z-1494081	ERR234595	lineage2.2.1	ru	Russia	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
177	I6L	L2	PZA	I	I6	6	L	0	Pre-XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	0622C-sc-2012-10-11T13:36:26Z-1494079,ERR234593	ERR234593	lineage2.2.1	ru	Russia,Samara	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
178	I6L	L2	PZA	I	I6	6	L	0	Pre-XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	1723Z-sc-2011-10-12T14:59:54Z-1289202,ERR117468	ERR117468	lineage2.2.1	ru	Russia,Samara	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
179	I6L	L2	PZA	I	I6	6	L	0	Pre-XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	2234E-sc-2012-10-11T13:38:05Z-1494181,ERR228017	ERR228017	lineage2.2.1	ru	Russia,Samara	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
180	I6L	L2	PZA	I	I6	6	L	NA	XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	ERR133843	ERR133843	lineage2.2.1	ru	Russia	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
181	I6L	L2	PZA	I	I6	6	L	0	Pre-XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	ERR158611,0031K-sc-2012-04-10T09:16:39Z-1397823	ERR158611	lineage2.2.1	ru	Russia,Samara	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
182	I6L	L2	PZA	I	I6	6	L	1	Pre-XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	0175R-sc-2011-09-07T13:18:49Z-1276425,ERR067578	ERR067578	lineage2.2.1	ru	Russia,Samara	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
183	I6L	L2	PZA	I	I6	6	L	0	Pre-XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	2385T-sc-2012-10-11T13:38:59Z-1494237,ERR229918	ERR229918	lineage2.2.1	ru	Russia,Samara	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
184	I6L	L2	PZA	I	I6	6	L	0	Pre-XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	1782N-sc-2012-02-21T11:37:25Z-1364785,ERR144548	ERR144548	lineage2.2.1	ru	Russia,Samara	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
185	I6L	L2	PZA	I	I6	6	L	0	Pre-XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	0076J-sc-2012-10-11T13:35:59Z-1494051,ERR234565	ERR234565	lineage2.2.1	ru	Russia,Samara	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
186	I6L	L2	PZA	I	I6	6	L	0	Pre-XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	0773R-sc-2012-02-09T18:57:01Z-1355263,ERR133930	ERR133930	lineage2.2.1	ru	Russia,Samara	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
187	I6L	L2	PZA	I	I6	6	L	0	Pre-XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	2338S-sc-2012-10-11T13:39:04Z-1494242,ERR229923	ERR229923	lineage2.2.1	ru	Russia,Samara	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
188	I6L	L2	PZA	I	I6	6	L	1	Pre-XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	ERR133915,0725P-sc-2012-02-09T18:56:50Z-1355248	ERR133915	lineage2.2.1	ru	Russia,Samara	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
189	I6L	L2	PZA	I	I6	6	L	NA	Pre-XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	ERR1023400	ERR1023400	lineage2.2.1			pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
190	I6L	L2	PZA	I	I6	6	L	0	Pre-XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	2089X-sc-2012-04-10T09:16:10Z-1397788,ERR158576	ERR158576	lineage2.2.1	ru	Russia,Samara	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
191	I6L	L2	PZA	I	I6	6	L	NA	Pre-XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	ERR067628	ERR067628	lineage2.2.1	ru	Russia	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
192	I6L	L2	PZA	I	I6	6	L	0	Pre-XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	ERR144590,1892H-sc-2012-02-21T11:38:01Z-1364827	ERR144590	lineage2.2.1	ru	Russia,Samara	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
193	I6L	L2	PZA	I	I6	6	L	NA	Pre-XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	ERR067662,0843S-sc-2011-09-07T13:19:38Z-1276509	ERR067662	lineage2.2.1	ru	Russia	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
194	I6L	L2	PZA	I	I6	6	L	0	Pre-XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	0571X-sc-2011-08-25T12:38:49Z-1262364,ERR067765	ERR067765	lineage2.2.1	ru	Russia,Samara	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
195	I6L	L2	PZA	I	I6	6	L	1	XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	ERR137204,1233R-sc-2012-02-21T11:36:23Z-1364696	ERR137204	lineage2.2.1	ru	Russia,Samara	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
196	I6L	L2	PZA	I	I6	6	L	0	XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	ERR158585,2127N-sc-2012-04-10T09:16:18Z-1397797	ERR158585	lineage2.2.1	ru	Russia,Samara	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
197	I6L	L2	PZA	I	I6	6	L	NA	XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	ERR234615,0442G-sc-2012-10-11T13:36:48Z-1494101	ERR234615	lineage2.2.1	ru	Russia	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
198	I6L	L2	PZA	I	I6	6	L	0	Pre-XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	ERR229946,2508C-sc-2012-10-11T13:39:26Z-1494265	ERR229946	lineage2.2.1	ru	Russia,Samara	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
199	I6L	L2	PZA	I	I6	6	L	0	XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	0960V-sc-2011-09-07T13:19:23Z-1276482,ERR067635	ERR067635	lineage2.2.1	ru	Russia,Samara	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
200	I6L	L2	PZA	I	I6	6	L	0	Pre-XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	ERR234609,0638V-sc-2012-10-11T13:36:42Z-1494095	ERR234609	lineage2.2.1	ru	Russia,Samara	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
201	I6L	L2	PZA	I	I6	6	L	0	XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	ERR067718,0157X-sc-2011-08-25T12:38:50Z-1262367	ERR067718	lineage2.2.1	ru	Russia,Samara	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
202	I6L	L4	PZA	I	I6	6	L	0	MDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage4	other_mutations_pyrazinamide	LEU	MDR_11168	SRR6824330	lineage4.5	cn	China: Luqiao District, Taizhou City, Zhejiang Province	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
203	I6L	L2	PZA	I	I6	6	L	NA	Pre-XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	1810T-sc-2012-02-21T11:37:28Z-1364790,ERR144553	ERR144553	lineage2.2.1	ru	Russia	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
204	I6L	L2	PZA	I	I6	6	L	1	MDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	ERR551494	ERR551494	lineage2.2.1	tm	Turkmenistan	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
205	I6L	L2	PZA	I	I6	6	L	0	Pre-XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	0609N-sc-2012-02-09T18:56:32Z-1355228,ERR133895	ERR133895	lineage2.2.1	ru	Russia,Samara	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
206	I6L	L2	PZA	I	I6	6	L	0	Pre-XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	0818Q-sc-2011-09-07T13:19:32Z-1276498,ERR067651	ERR067651	lineage2.2.1	ru	Russia,Samara	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
207	I6L	L2	PZA	I	I6	6	L	NA	XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	SRR7517822	SRR7517822	lineage2.2.1	ch	Switzerland	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
208	I6L	L2	PZA	I	I6	6	L	0	Pre-XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	ERR158613,0145J-sc-2012-04-10T09:16:40Z-1397825	ERR158613	lineage2.2.1	ru	Russia,Samara	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
209	I6L	L2	PZA	I	I6	6	L	0	Pre-XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	2516L-sc-2012-10-11T13:40:12Z-1494313,ERR229994	ERR229994	lineage2.2.1	ru	Russia,Samara	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
210	I6L	L2	PZA	I	I6	6	L	0	XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	ERR234560,0469L-sc-2012-10-11T13:35:54Z-1494046	ERR234560	lineage2.2.1	ru	Russia,Samara	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
211	I6L	L2	PZA	I	I6	6	L	1	Pre-XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	0259H-sc-2012-02-09T18:55:43Z-1355160,ERR133827	ERR133827	lineage2.2.1	ru	Russia,Samara	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
212	I6L	L2	PZA	I	I6	6	L	0	Pre-XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	1797E-sc-2012-02-21T11:37:25Z-1364786,ERR144549	ERR144549	lineage2.2.1	ru	Russia,Samara	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
213	I6L	L2	PZA	I	I6	6	L	0	Pre-XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	1825K-sc-2012-02-21T11:37:36Z-1364799,ERR144562	ERR144562	lineage2.2.1	ru	Russia,Samara	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
214	I6L	L2	PZA	I	I6	6	L	NA	Pre-XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	1736N-sc-2012-02-21T11:37:09Z-1364764,ERR137272	ERR137272	lineage2.2.1	ru	Russia	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
215	I6L	L2	PZA	I	I6	6	L	0	Pre-XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	ERR067587,0345B-sc-2011-09-07T13:18:54Z-1276434	ERR067587	lineage2.2.1	ru	Russia,Samara	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
216	I6L	L2	PZA	I	I6	6	L	0	XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	ERR234576,0495P-sc-2012-10-11T13:36:09Z-1494062	ERR234576	lineage2.2.1	ru	Russia,Samara	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
217	I6L	L2	PZA	I	I6	6	L	0	Pre-XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	0816N-sc-2011-09-07T13:19:31Z-1276496,ERR067649	ERR067649	lineage2.2.1	ru	Russia,Samara	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
218	I6L	L2	PZA	I	I6	6	L	0	Pre-XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	ERR234623,0462D-sc-2012-10-11T13:36:55Z-1494109	ERR234623	lineage2.2.1	ru	Russia,Samara	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
219	I6L	L2	PZA	I	I6	6	L	0	Pre-XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	0475S-sc-2011-08-25T12:38:43Z-1262353,ERR067754	ERR067754	lineage2.2.1	ru	Russia,Samara	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
220	I6L	L2	PZA	I	I6	6	L	0	Pre-XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	0570W-sc-2012-02-09T18:56:25Z-1355219,ERR133886	ERR133886	lineage2.2.1	ru	Russia,Samara	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
221	I6L	L2	PZA	I	I6	6	L	NA	XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	0391B-sc-2011-09-07T13:19:16Z-1276470,ERR067623	ERR067623	lineage2.2.1	ru	Russia	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
222	I6L	L2	PZA	I	I6	6	L	0	Pre-XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	ERR117470,1346P-sc-2011-10-12T14:59:56Z-1289204	ERR117470	lineage2.2.1	ru	Russia,Samara	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
223	I6L	L2	PZA	I	I6	6	L	NA	XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	ERR133848,0330K-sc-2012-02-09T18:55:57Z-1355181	ERR133848	lineage2.2.1	ru	Russia	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
224	I6L	L2	PZA	I	I6	6	L	NA	Pre-XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	0383S-sc-2011-08-25T12:38:35Z-1262338,ERR067739	ERR067739	lineage2.2.1	ru	Russia	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
225	I6L	L2	PZA	I	I6	6	L	0	Pre-XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	2639V-sc-2012-10-11T13:41:12Z-1494376,ERR234698	ERR234698	lineage2.2.1	ru	Russia,Samara	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
226	I6L	L2	PZA	I	I6	6	L	NA	Pre-XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	ERR108491,1040G-sc-2011-10-12T14:59:22Z-1289156	ERR108491	lineage2.2.1	ru	Russia	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
227	I6L	L2;L4	PZA	I	I6	6	L	0	Pre-XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2;lineage4	other_mutations_pyrazinamide	LEU	2549X-sc-2012-10-11T13:40:42Z-1494344,ERR234666	ERR234666	lineage4;lineage2.2.1	ru	Russia,Samara	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
228	I6L	L2	PZA	I	I6	6	L	0	Pre-XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	ERR228020,2311N-sc-2012-10-11T13:38:07Z-1494184	ERR228020	lineage2.2.1	ru	Russia,Samara	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
229	I6L	L2	PZA	I	I6	6	L	NA	Pre-XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	ERR108454	ERR108454	lineage2.2.1	ru	Russia	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
230	I6L	L2	PZA	I	I6	6	L	0	Pre-XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	ERR027455	ERR027455	lineage2.2.1	ru	Russia	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
231	I6L	L2	PZA	I	I6	6	L	0	Pre-XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	ERR108489,1030W-sc-2011-10-12T14:59:20Z-1289154	ERR108489	lineage2.2.1	ru	Russia,Samara	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
232	I6L	L2	PZA	I	I6	6	L	0	Pre-XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	ERR228064,2215J-sc-2012-10-11T13:38:50Z-1494228	ERR228064	lineage2.2.1	ru	Russia,Samara	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
233	I6L	L2	PZA	I	I6	6	L	0	Pre-XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	2135X-sc-2012-04-10T09:16:22Z-1397802,ERR158590	ERR158590	lineage2.2.1	ru	Russia,Samara	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
234	I6L	L2	PZA	I	I6	6	L	0	Pre-XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	ERR229924,2352H-sc-2012-10-11T13:39:05Z-1494243	ERR229924	lineage2.2.1	ru	Russia,Samara	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
235	I6L	L2	PZA	I	I6	6	L	NA	XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	0481Z-sc-2012-10-11T13:36:01Z-1494054,ERR234568	ERR234568	lineage2.2.1	ru	Russia	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
236	I6L	L2	PZA	I	I6	6	L	0	Pre-XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	ERR144597,1917K-sc-2012-02-21T11:38:05Z-1364834	ERR144597	lineage2.2.1	ru	Russia,Samara	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
237	I6L	L2	PZA	I	I6	6	L	NA	Pre-XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	0833G-sc-2011-09-07T13:19:34Z-1276501,ERR067654	ERR067654	lineage2.2.1	ru	Russia,Samara	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
238	I6L	L2;L4	PZA	I	I6	6	L	0	Pre-XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2;lineage4	other_mutations_pyrazinamide	LEU	ERR234570,0658R-sc-2012-10-11T13:36:03Z-1494056	ERR234570	lineage4;lineage2.2.1	ru	Russia,Samara	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
239	I6L	L2	PZA	I	I6	6	L	0	Pre-XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	0666A-sc-2012-10-11T13:36:50Z-1494104,ERR234618	ERR234618	lineage2.2.1	ru	Russia,Samara	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
240	I6L	L2	PZA	I	I6	6	L	0	XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	1921P-sc-2012-02-21T11:38:08Z-1364837,ERR144600	ERR144600	lineage2.2.1	ru	Russia,Samara	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
241	I6L	L2	PZA	I	I6	6	L	0	Pre-XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	2072D-sc-2012-02-21T11:38:30Z-1364870,ERR144632	ERR144632	lineage2.2.1	ru	Russia,Samara	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
242	I6L	L2	PZA	I	I6	6	L	0	Pre-XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	ERR067663,0844T-sc-2011-09-07T13:19:39Z-1276510	ERR067663	lineage2.2.1	ru	Russia,Samara	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
243	I6L	L2	PZA	I	I6	6	L	0	Pre-XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	1366L-sc-2012-02-21T11:36:34Z-1364712,ERR137220	ERR137220	lineage2.2.1	ru	Russia,Samara	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
244	I6L	L2	PZA	I	I6	6	L	0	Pre-XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	ERR228019,2287M-sc-2012-10-11T13:38:07Z-1494183	ERR228019	lineage2.2.1	ru	Russia,Samara	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
245	I6L	L2	PZA	I	I6	6	L	NA	Pre-XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	2369B-sc-2012-10-11T13:39:13Z-1494252,ERR229933	ERR229933	lineage2.2.1	ru	Russia	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
246	I6L	L2	PZA	I	I6	6	L	NA	Pre-XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	2249W-sc-2012-10-11T13:37:27Z-1494142,ERR227978	ERR227978	lineage2.2.1	ru	Russia	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
247	I6L	L2	PZA	I	I6	6	L	0	Pre-XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	ERR133953,0826Z-sc-2012-02-09T18:57:18Z-1355286	ERR133953	lineage2.2.1	ru	Russia,Samara	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
248	I6L	L2	PZA	I	I6	6	L	NA	Pre-XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	ERR158597,2152Q-sc-2012-04-10T09:16:26Z-1397809	ERR158597	lineage2.2.1	ru	Russia	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
249	I6L	L2	PZA	I	I6	6	L	NA	Pre-XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	ETB0088	SRR6257030	lineage2.2.1	ru	Russia:Samara	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
250	I6L	L2	PZA	I	I6	6	L	0	Pre-XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	1705E-sc-2012-02-21T11:37:02Z-1364754,ERR137262	ERR137262	lineage2.2.1	ru	Russia,Samara	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
251	I6L	L2	PZA	I	I6	6	L	0	XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	ERR067704,1467W-sc-2011-09-07T13:20:04Z-1276551	ERR067704	lineage2.2.1	ru	Russia,Samara	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
252	I6L	L2	PZA	I	I6	6	L	0	XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	ERR144611,2011M-sc-2012-02-21T11:38:15Z-1364848	ERR144611	lineage2.2.1	ru	Russia,Samara	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
253	I6L	L2	PZA	I	I6	6	L	NA	Pre-XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	ERR228054	ERR228054	lineage2.2.1	ru	Russia	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
254	I6L	L2	PZA	I	I6	6	L	NA	Pre-XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	SAMN02414916	SRR1146417_SRR1162881_SRR1163087_SRR1144810	lineage2.2.1	se	Sweden	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
255	I6L	L2	PZA	I	I6	6	L	0	Pre-XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	1596L-sc-2011-10-12T14:58:40Z-1289101,ERR108436	ERR108436	lineage2.2.1	ru	Russia,Samara	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
256	I6L	L2	PZA	I	I6	6	L	NA	XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	0187E-sc-2011-08-25T12:38:22Z-1262319,ERR067720	ERR067720	lineage2.2.1	ru	Russia	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
257	I6L	L2	PZA	I	I6	6	L	NA	Pre-XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	ERR027458	ERR027458	lineage2.2.1	ru	Russia	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
258	I6L	L2	PZA	I	I6	6	L	0	XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	ERR229960,2484B-sc-2012-10-11T13:39:39Z-1494279	ERR229960	lineage2.2.1	ru	Russia,Samara	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
259	I6L	L2	PZA	I	I6	6	L	0	XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	ERR227996,2308K-sc-2012-10-11T13:37:45Z-1494160	ERR227996	lineage2.2.1	ru	Russia,Samara	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
260	I6L	L2	PZA	I	I6	6	L	0	Pre-XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	ERR133806,0126N-sc-2012-02-09T18:55:27Z-1355139	ERR133806	lineage2.2.1	ru	Russia,Samara	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
261	I6L	L4	PZA	I	I6	6	L	NA	MDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage4	other_mutations_pyrazinamide	LEU	ERR2179654	ERR2179654	lineage4.5	cn	China	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
262	I6L	L2	PZA	I	I6	6	L	NA	Pre-XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	ERR108484,1002Q-sc-2011-10-12T14:59:16Z-1289149	ERR108484	lineage2.2.1	ru	Russia	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
263	I6L	L2	PZA	I	I6	6	L	NA	Pre-XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	ERR229980,2362T-sc-2012-10-11T13:39:58Z-1494299	ERR229980	lineage2.2.1	ru	Russia	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
264	I6L	L2	PZA	I	I6	6	L	0	Pre-XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	0928K-sc-2011-10-12T14:59:49Z-1289194,ERR117460	ERR117460	lineage2.2.1	ru	Russia,Samara	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
265	I6L	L2	PZA	I	I6	6	L	0	Pre-XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	ERR137281,1755J-sc-2012-02-21T11:37:17Z-1364773	ERR137281	lineage2.2.1	ru	Russia,Samara	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
266	I6L	L2	PZA	I	I6	6	L	0	Pre-XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	ERR158586,2128P-sc-2012-04-10T09:16:18Z-1397798	ERR158586	lineage2.2.1	ru	Russia,Samara	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
267	I6L	L2	PZA	I	I6	6	L	NA	Pre-XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	ERR067741,0386W-sc-2011-08-25T12:38:36Z-1262340	ERR067741	lineage2.2.1	ru	Russia	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
268	I6L	L2	PZA	I	I6	6	L	0	Pre-XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	ERR067762,0512H-sc-2011-08-25T12:38:47Z-1262361	ERR067762	lineage2.2.1	ru	Russia,Samara	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
269	I6L	L2	PZA	I	I6	6	L	0	Pre-XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	ERR133826,0255D-sc-2012-02-09T18:55:42Z-1355159	ERR133826	lineage2.2.1	ru	Russia,Samara	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
270	I6L	L2	PZA	I	I6	6	L	0	Pre-XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	1559W-sc-2011-09-07T13:20:10Z-1276562,ERR067715	ERR067715	lineage2.2.1	ru	Russia,Samara	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
271	I6L	L4	PZA	I	I6	6	L	NA	MDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage4	other_mutations_pyrazinamide	LEU	SRS797396	SRR1723935	lineage4.5	cn	China:Zhejiang	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
272	I6L	L2	PZA	I	I6	6	L	0	XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	ERR234633,0647E-sc-2012-10-11T13:37:05Z-1494119	ERR234633	lineage2.2.1	ru	Russia,Samara	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
273	I6L	L2	PZA	I	I6	6	L	1	Pre-XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	0338T-sc-2012-10-11T13:36:54Z-1494108,ERR234622	ERR234622	lineage2.2.1	ru	Russia,Samara	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
274	I6L	L2	PZA	I	I6	6	L	0	Pre-XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	ERR133889,0590S-sc-2012-02-09T18:56:26Z-1355222	ERR133889	lineage2.2.1	ru	Russia,Samara	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
275	I6L	L2	PZA	I	I6	6	L	0	Pre-XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	ERR067583,0217M-sc-2011-09-07T13:18:51Z-1276430	ERR067583	lineage2.2.1	ru	Russia,Samara	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
276	I6L	L2	PZA	I	I6	6	L	0	Pre-XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	0897B-sc-2011-10-12T14:58:57Z-1289123,ERR108458	ERR108458	lineage2.2.1	ru	Russia,Samara	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
277	I6L	L2	PZA	I	I6	6	L	0	Pre-XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	1271H-sc-2012-02-21T11:36:28Z-1364702,ERR137210	ERR137210	lineage2.2.1	ru	Russia,Samara	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
278	I6L	L2	PZA	I	I6	6	L	0	XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	ERR234641,0649G-sc-2012-10-11T13:37:13Z-1494127	ERR234641	lineage2.2.1	ru	Russia,Samara	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
279	I6L	L2	PZA	I	I6	6	L	NA	Pre-XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	1474D-sc-2011-09-07T13:20:08Z-1276557,ERR067710	ERR067710	lineage2.2.1	ru	Russia	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
280	I6L	L2	PZA	I	I6	6	L	0	Pre-XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	1860Y-sc-2012-02-21T11:37:46Z-1364812,ERR144575	ERR144575	lineage2.2.1	ru	Russia,Samara	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
281	I6L	L2	PZA	I	I6	6	L	0	Pre-XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	ERR067656,0835J-sc-2011-09-07T13:19:35Z-1276503	ERR067656	lineage2.2.1	ru	Russia,Samara	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
282	I6L	L2	PZA	I	I6	6	L	1	Pre-XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	ETB0040	SRR6257082	lineage2.2.1	ru	Russia:Samara	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
283	I6L	L2	PZA	I	I6	6	L	0	Pre-XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	ERR019564	ERR019564	lineage2.2.1	ru	Russia	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
284	I6L	L2	PZA	I	I6	6	L	NA	XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	0312Q-sc-2012-02-09T18:55:55Z-1355178,ERR133845	ERR133845	lineage2.2.1	ru	Russia	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
285	I6L	L2	PZA	I	I6	6	L	0	XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	ERR144593,1901S-sc-2012-02-21T11:38:03Z-1364830	ERR144593	lineage2.2.1	ru	Russia,Samara	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
286	I6L	L2	PZA	I	I6	6	L	0	Pre-XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	0273Y-sc-2012-02-09T18:55:45Z-1355164,ERR133831	ERR133831	lineage2.2.1	ru	Russia,Samara	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
287	I6L	L2	PZA	I	I6	6	L	0	XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	ERR144543,1770A-sc-2012-02-21T11:37:22Z-1364780	ERR144543	lineage2.2.1	ru	Russia,Samara	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
288	I6L	L2	PZA	I	I6	6	L	0	Pre-XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	ERR137283,1765V-sc-2012-02-21T11:37:18Z-1364775	ERR137283	lineage2.2.1	ru	Russia,Samara	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
289	I6L	L2	PZA	I	I6	6	L	0	Pre-XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	ERR019559	ERR019559	lineage2.2.1	ru	Russia	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
290	I6L	L2	PZA	I	I6	6	L	0	Pre-XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	0163D-sc-2011-09-07T13:18:46Z-1276423,ERR067576	ERR067576	lineage2.2.1	ru	Russia,Samara	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
291	I6L	L2	PZA	I	I6	6	L	0	Pre-XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	ERR067620,0053J-sc-2011-09-07T13:19:14Z-1276467	ERR067620	lineage2.2.1	ru	Russia,Samara	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
292	I6L	L2	PZA	I	I6	6	L	0	XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	ERR229962,2512G-sc-2012-10-11T13:39:41Z-1494281	ERR229962	lineage2.2.1	ru	Russia,Samara	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
293	I6L	L2	PZA	I	I6	6	L	0	Pre-XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	0817P-sc-2011-09-07T13:19:31Z-1276497,ERR067650	ERR067650	lineage2.2.1	ru	Russia,Samara	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
294	I6L	L2	PZA	I	I6	6	L	0	Pre-XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	ERR234574,0283J-sc-2012-10-11T13:36:07Z-1494060	ERR234574	lineage2.2.1	ru	Russia,Samara	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
295	I6L	L2	PZA	I	I6	6	L	0	XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	ERR234590,0292T-sc-2012-10-11T13:36:23Z-1494076	ERR234590	lineage2.2.1	ru	Russia,Samara	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
296	I6L	L2	PZA	I	I6	6	L	0	Pre-XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	ERR067613,0628J-sc-2011-09-07T13:19:09Z-1276460	ERR067613	lineage2.2.1	ru	Russia,Samara	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
297	I6L	L2	PZA	I	I6	6	L	NA	Pre-XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	ERR133853,0388Y-sc-2012-02-09T18:56:01Z-1355186	ERR133853	lineage2.2.1	ru	Russia	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
298	I6L	L2	PZA	I	I6	6	L	0	Pre-XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	1475E-sc-2011-09-07T13:20:08Z-1276558,ERR067711	ERR067711	lineage2.2.1	ru	Russia,Samara	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
299	I6L	L2	PZA	I	I6	6	L	NA	Pre-XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	ERR067652,0828B-sc-2011-09-07T13:19:33Z-1276499	ERR067652	lineage2.2.1	ru	Russia	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
300	I6L	L2	PZA	I	I6	6	L	0	Pre-XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	ERR234660,2535G-sc-2012-10-11T13:40:36Z-1494338	ERR234660	lineage2.2.1	ru	Russia,Samara	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
301	I6L	L2	PZA	I	I6	6	L	0	Pre-XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	1432H-sc-2012-02-21T11:36:41Z-1364722,ERR137230	ERR137230	lineage2.2.1	ru	Russia,Samara	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
302	I6L	L2	PZA	I	I6	6	L	0	Pre-XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	0071D-sc-2011-10-12T14:59:29Z-1289167,ERR108502	ERR108502	lineage2.2.1	ru	Russia,Samara	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
303	I6L	L2	PZA	I	I6	6	L	NA	Pre-XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	2281F-sc-2012-10-11T13:37:44Z-1494159,ERR227995	ERR227995	lineage2.2.1	ru	Russia	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
304	I6L	L2	PZA	I	I6	6	L	NA	XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	ERR229916,2351G-sc-2012-10-11T13:38:57Z-1494235	ERR229916	lineage2.2.1	ru	Russia	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
305	I6L	L2	PZA	I	I6	6	L	0	Pre-XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	2052G-sc-2012-02-21T11:38:26Z-1364865,ERR144628	ERR144628	lineage2.2.1	ru	Russia,Samara	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
306	I6L	L2	PZA	I	I6	6	L	NA	Pre-XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	0052H-sc-2012-10-11T13:37:00Z-1494114,ERR234628	ERR234628	lineage2.2.1	ru	Russia	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
307	I6L	L2	PZA	I	I6	6	L	0	Pre-XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	ERR133944,0799V-sc-2012-02-09T18:57:11Z-1355277	ERR133944	lineage2.2.1	ru	Russia,Samara	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
308	I6L	L2	PZA	I	I6	6	L	NA	Pre-XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	ERR137211,1284X-sc-2012-02-21T11:36:28Z-1364703	ERR137211	lineage2.2.1	ru	Russia	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
309	I6L	L2	PZA	I	I6	6	L	0	Pre-XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	ERR137222,1391N-sc-2012-02-21T11:36:35Z-1364714	ERR137222	lineage2.2.1	ru	Russia,Samara	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
310	I6L	L2	PZA	I	I6	6	L	0	Pre-XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	ERR137269,1731H-sc-2012-02-21T11:37:07Z-1364761	ERR137269	lineage2.2.1	ru	Russia,Samara	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
311	I6L	L2	PZA	I	I6	6	L	0	Pre-XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	ERR133868,0484C-sc-2012-02-09T18:56:12Z-1355201	ERR133868	lineage2.2.1	ru	Russia,Samara	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
312	I6L	L2	PZA	I	I6	6	L	0	Pre-XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	1741T-sc-2012-02-21T11:37:13Z-1364769,ERR137277	ERR137277	lineage2.2.1	ru	Russia,Samara	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
313	I6L	L2	PZA	I	I6	6	L	0	Pre-XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	2053H-sc-2012-10-11T13:38:32Z-1494210,ERR228046	ERR228046	lineage2.2.1	ru	Russia,Samara	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
314	I6L	L2	PZA	I	I6	6	L	0	Pre-XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	0978P-sc-2011-10-12T14:59:09Z-1289140,ERR108475	ERR108475	lineage2.2.1	ru	Russia,Samara	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
315	I6L	L2	PZA	I	I6	6	L	NA	Pre-XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.018	-0.548	0.267883	-1.616	-0.58	5	53	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0097024579560155	0.385310257492613	0.385311080310026	0.385326683377145	8.35414540919546	-6	0	0	0	0	0	0	0	-7	0	-2	-5	2	-2	-2	-0.764437689969605	-0.141602067183462	0.00975688197029407	-0.275532821824382	-0.151832460732984	0.0526315789473684	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	-0.953704270146009	0.0037560422096937	0.329095586242593	-2.89795521427317	0.189089468462042	0.697385389891155	-0.414189429312607	0.0017355697972772	2.76055791615401	0.180049643960023	0.733980750878148	0.0038480840706912	lineage2	other_mutations_pyrazinamide	LEU	ERR019575	ERR019575	lineage2.2.1	ru	Russia	pnca_p.ile6leu	A	E	ILE	IA6	pnca_complex.pdb
316	I6M	L4	PZA	I	I6	6	M	NA	MDR	DM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-3.085	-1.021	0.24349	-2.364	0.14	10	59	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	NA	NA	NA	NA	NA	-32	0	0	0	0	0	0	0	-3	0	0	-3	-2	-4	-2	-0.781408308004053	-0.263824289405685	0.00886843581319794	-0.40306905370844	0.0786516853932584	0.105263157894737	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Stabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	lineage4	dr_mutations_pyrazinamide	MET	ERR1555057	ERR1555057	lineage4.3.3			pnca_p.ile6met	A	E	ILE	IA6	pnca_complex.pdb
317	I6S	L2	PZA	I	I6	6	S	1	Pre-XDR	DM	hydrophobic	hydrophilic	non-polar	neutral	non-polar	polar	9.258	-1.047	-3.585	6.01751	-4.149	-3.42	64	80	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0001437401178668	19.411022297013	511754.463552573	Inf	4.73122070382274	24	0	0	0	0	0	-2	0	-1	0	-1	0	2	4	0	-0.265197568389058	-0.926356589147287	0.219170812724452	-0.707416879795396	-0.895287958115183	0.673684210526316	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	13.1456002256205	0.924803768446996	139.277183326562	0.094384449136928	0.0001628371344453	NA	1.28804840845689	0.0292235860951597	1.53426649183163	0.91081598550184	Inf	0.0296198560706035	lineage2	dr_mutations_pyrazinamide	SER	ERR2516977	ERR2516977	lineage2.2.1	gb	UK	pnca_p.ile6ser	A	E	ILE	IA6	pnca_complex.pdb
318	I6S	L2	PZA	I	I6	6	S	1	Pre-XDR	DM	hydrophobic	hydrophilic	non-polar	neutral	non-polar	polar	9.258	-1.047	-3.585	6.01751	-4.149	-3.42	64	80	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.0001437401178668	19.411022297013	511754.463552573	Inf	4.73122070382274	24	0	0	0	0	0	-2	0	-1	0	-1	0	2	4	0	-0.265197568389058	-0.926356589147287	0.219170812724452	-0.707416879795396	-0.895287958115183	0.673684210526316	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	13.1456002256205	0.924803768446996	139.277183326562	0.094384449136928	0.0001628371344453	NA	1.28804840845689	0.0292235860951597	1.53426649183163	0.91081598550184	Inf	0.0296198560706035	lineage2	dr_mutations_pyrazinamide	SER	ERR2516895	ERR2516895	lineage2.2.1	gb	UK	pnca_p.ile6ser	A	E	ILE	IA6	pnca_complex.pdb
319	I6T	L2	PZA	I	I6	6	T	1	XDR	DM	hydrophobic	hydrophobic	non-polar	neutral	non-polar	polar	9.258	-1.244	-3.089	3.71452	-3.589	-3.14	62	80	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.000646830530401	87.6075949367089	1395214.80217275	Inf	38.0099632572142	24	0	0	0	0	0	-2	0	-1	0	-1	0	2	0	0	-0.315096251266464	-0.798191214470284	0.135290903925582	-0.611935208866155	-0.821989528795812	0.652631578947368	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	14.148558941436	0.896008552350165	108.247901039825	0.130705157379733	226.474535586036	NA	1.94254175795031	1.23317897951184e-07	6.90897388676731	9.59561062779463	Inf	7.038428913028e-10	lineage2	dr_mutations_pyrazinamide	THR	ERR2510686	ERR2510686	lineage2.2.1	it	Italy	pnca_p.ile6thr	A	E	ILE	IA6	pnca_complex.pdb
320	I6T	L1	PZA	I	I6	6	T	NA	MDR	DM	hydrophobic	hydrophobic	non-polar	neutral	non-polar	polar	9.258	-1.244	-3.089	3.71452	-3.589	-3.14	62	80	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.000646830530401	87.6075949367089	1395214.80217275	Inf	38.0099632572142	24	0	0	0	0	0	-2	0	-1	0	-1	0	2	0	0	-0.315096251266464	-0.798191214470284	0.135290903925582	-0.611935208866155	-0.821989528795812	0.652631578947368	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	14.148558941436	0.896008552350165	108.247901039825	0.130705157379733	226.474535586036	NA	1.94254175795031	1.23317897951184e-07	6.90897388676731	9.59561062779463	Inf	7.038428913028e-10	lineage1	dr_mutations_pyrazinamide	THR	SAMN02414908	SRR1163076_SRR1144791_SRR1163465_SRR1146277	lineage1.1.2	se	Sweden	pnca_p.ile6thr	A	E	ILE	IA6	pnca_complex.pdb
321	I6T	L4	PZA	I	I6	6	T	1	Pre-XDR	DM	hydrophobic	hydrophobic	non-polar	neutral	non-polar	polar	9.258	-1.244	-3.089	3.71452	-3.589	-3.14	62	80	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.000646830530401	87.6075949367089	1395214.80217275	Inf	38.0099632572142	24	0	0	0	0	0	-2	0	-1	0	-1	0	2	0	0	-0.315096251266464	-0.798191214470284	0.135290903925582	-0.611935208866155	-0.821989528795812	0.652631578947368	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	14.148558941436	0.896008552350165	108.247901039825	0.130705157379733	226.474535586036	NA	1.94254175795031	1.23317897951184e-07	6.90897388676731	9.59561062779463	Inf	7.038428913028e-10	lineage4	dr_mutations_pyrazinamide	THR	ERR2510434	ERR2510434	lineage4.9	pk	Pakistan	pnca_p.ile6thr	A	E	ILE	IA6	pnca_complex.pdb
322	I6T	L2	PZA	I	I6	6	T	1	XDR	DM	hydrophobic	hydrophobic	non-polar	neutral	non-polar	polar	9.258	-1.244	-3.089	3.71452	-3.589	-3.14	62	80	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.000646830530401	87.6075949367089	1395214.80217275	Inf	38.0099632572142	24	0	0	0	0	0	-2	0	-1	0	-1	0	2	0	0	-0.315096251266464	-0.798191214470284	0.135290903925582	-0.611935208866155	-0.821989528795812	0.652631578947368	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	14.148558941436	0.896008552350165	108.247901039825	0.130705157379733	226.474535586036	NA	1.94254175795031	1.23317897951184e-07	6.90897388676731	9.59561062779463	Inf	7.038428913028e-10	lineage2	dr_mutations_pyrazinamide	THR	ERR2510710	ERR2510710	lineage2.2.1	it	Italy	pnca_p.ile6thr	A	E	ILE	IA6	pnca_complex.pdb
323	I6T	L2	PZA	I	I6	6	T	1	XDR	DM	hydrophobic	hydrophobic	non-polar	neutral	non-polar	polar	9.258	-1.244	-3.089	3.71452	-3.589	-3.14	62	80	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.000646830530401	87.6075949367089	1395214.80217275	Inf	38.0099632572142	24	0	0	0	0	0	-2	0	-1	0	-1	0	2	0	0	-0.315096251266464	-0.798191214470284	0.135290903925582	-0.611935208866155	-0.821989528795812	0.652631578947368	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	14.148558941436	0.896008552350165	108.247901039825	0.130705157379733	226.474535586036	NA	1.94254175795031	1.23317897951184e-07	6.90897388676731	9.59561062779463	Inf	7.038428913028e-10	lineage2	dr_mutations_pyrazinamide	THR	ERR2510690	ERR2510690	lineage2.2.1	it	Italy	pnca_p.ile6thr	A	E	ILE	IA6	pnca_complex.pdb
324	I6T	L2	PZA	I	I6	6	T	1	XDR	DM	hydrophobic	hydrophobic	non-polar	neutral	non-polar	polar	9.258	-1.244	-3.089	3.71452	-3.589	-3.14	62	80	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.000646830530401	87.6075949367089	1395214.80217275	Inf	38.0099632572142	24	0	0	0	0	0	-2	0	-1	0	-1	0	2	0	0	-0.315096251266464	-0.798191214470284	0.135290903925582	-0.611935208866155	-0.821989528795812	0.652631578947368	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	14.148558941436	0.896008552350165	108.247901039825	0.130705157379733	226.474535586036	NA	1.94254175795031	1.23317897951184e-07	6.90897388676731	9.59561062779463	Inf	7.038428913028e-10	lineage2	dr_mutations_pyrazinamide	THR	ERR2510703	ERR2510703	lineage2.2.1	it	Italy	pnca_p.ile6thr	A	E	ILE	IA6	pnca_complex.pdb
325	I6T	L2	PZA	I	I6	6	T	NA	Pre-XDR	DM	hydrophobic	hydrophobic	non-polar	neutral	non-polar	polar	9.258	-1.244	-3.089	3.71452	-3.589	-3.14	62	80	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.000646830530401	87.6075949367089	1395214.80217275	Inf	38.0099632572142	24	0	0	0	0	0	-2	0	-1	0	-1	0	2	0	0	-0.315096251266464	-0.798191214470284	0.135290903925582	-0.611935208866155	-0.821989528795812	0.652631578947368	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	14.148558941436	0.896008552350165	108.247901039825	0.130705157379733	226.474535586036	NA	1.94254175795031	1.23317897951184e-07	6.90897388676731	9.59561062779463	Inf	7.038428913028e-10	lineage2	dr_mutations_pyrazinamide	THR	SAMN02414851	SRR1162709_SRR1166864_SRR1165553_SRR1165535	lineage2.2.1	se	Sweden	pnca_p.ile6thr	A	E	ILE	IA6	pnca_complex.pdb
326	I6T	L2	PZA	I	I6	6	T	NA	Pre-XDR	DM	hydrophobic	hydrophobic	non-polar	neutral	non-polar	polar	9.258	-1.244	-3.089	3.71452	-3.589	-3.14	62	80	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.000646830530401	87.6075949367089	1395214.80217275	Inf	38.0099632572142	24	0	0	0	0	0	-2	0	-1	0	-1	0	2	0	0	-0.315096251266464	-0.798191214470284	0.135290903925582	-0.611935208866155	-0.821989528795812	0.652631578947368	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	14.148558941436	0.896008552350165	108.247901039825	0.130705157379733	226.474535586036	NA	1.94254175795031	1.23317897951184e-07	6.90897388676731	9.59561062779463	Inf	7.038428913028e-10	lineage2	dr_mutations_pyrazinamide	THR	SAMN02414859	SRR1165540_SRR1165563_SRR1162741_SRR1166932	lineage2.2.1	se	Sweden	pnca_p.ile6thr	A	E	ILE	IA6	pnca_complex.pdb
327	I6T	L2	PZA	I	I6	6	T	1	MDR	DM	hydrophobic	hydrophobic	non-polar	neutral	non-polar	polar	9.258	-1.244	-3.089	3.71452	-3.589	-3.14	62	80	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.000646830530401	87.6075949367089	1395214.80217275	Inf	38.0099632572142	24	0	0	0	0	0	-2	0	-1	0	-1	0	2	0	0	-0.315096251266464	-0.798191214470284	0.135290903925582	-0.611935208866155	-0.821989528795812	0.652631578947368	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	14.148558941436	0.896008552350165	108.247901039825	0.130705157379733	226.474535586036	NA	1.94254175795031	1.23317897951184e-07	6.90897388676731	9.59561062779463	Inf	7.038428913028e-10	lineage2	dr_mutations_pyrazinamide	THR	1530P-sc-2011-10-12T14:58:51Z-1289115,ERR108450	ERR108450	lineage2.2.1	ru	Russia,Samara	pnca_p.ile6thr	A	E	ILE	IA6	pnca_complex.pdb
328	I6T	L2	PZA	I	I6	6	T	1	XDR	DM	hydrophobic	hydrophobic	non-polar	neutral	non-polar	polar	9.258	-1.244	-3.089	3.71452	-3.589	-3.14	62	80	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.000646830530401	87.6075949367089	1395214.80217275	Inf	38.0099632572142	24	0	0	0	0	0	-2	0	-1	0	-1	0	2	0	0	-0.315096251266464	-0.798191214470284	0.135290903925582	-0.611935208866155	-0.821989528795812	0.652631578947368	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	14.148558941436	0.896008552350165	108.247901039825	0.130705157379733	226.474535586036	NA	1.94254175795031	1.23317897951184e-07	6.90897388676731	9.59561062779463	Inf	7.038428913028e-10	lineage2	dr_mutations_pyrazinamide	THR	ERR2510723	ERR2510723	lineage2.2.1	it	Italy	pnca_p.ile6thr	A	E	ILE	IA6	pnca_complex.pdb
329	I6T	L2	PZA	I	I6	6	T	1	XDR	DM	hydrophobic	hydrophobic	non-polar	neutral	non-polar	polar	9.258	-1.244	-3.089	3.71452	-3.589	-3.14	62	80	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.000646830530401	87.6075949367089	1395214.80217275	Inf	38.0099632572142	24	0	0	0	0	0	-2	0	-1	0	-1	0	2	0	0	-0.315096251266464	-0.798191214470284	0.135290903925582	-0.611935208866155	-0.821989528795812	0.652631578947368	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	14.148558941436	0.896008552350165	108.247901039825	0.130705157379733	226.474535586036	NA	1.94254175795031	1.23317897951184e-07	6.90897388676731	9.59561062779463	Inf	7.038428913028e-10	lineage2	dr_mutations_pyrazinamide	THR	ERR2510709	ERR2510709	lineage2.2.1	it	Italy	pnca_p.ile6thr	A	E	ILE	IA6	pnca_complex.pdb
330	I6T	L2	PZA	I	I6	6	T	1	XDR	DM	hydrophobic	hydrophobic	non-polar	neutral	non-polar	polar	9.258	-1.244	-3.089	3.71452	-3.589	-3.14	62	80	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	0.000646830530401	87.6075949367089	1395214.80217275	Inf	38.0099632572142	24	0	0	0	0	0	-2	0	-1	0	-1	0	2	0	0	-0.315096251266464	-0.798191214470284	0.135290903925582	-0.611935208866155	-0.821989528795812	0.652631578947368	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.728	-0.553	8:7	146/150	M:A:I:L:V	14.148558941436	0.896008552350165	108.247901039825	0.130705157379733	226.474535586036	NA	1.94254175795031	1.23317897951184e-07	6.90897388676731	9.59561062779463	Inf	7.038428913028e-10	lineage2	dr_mutations_pyrazinamide	THR	ERR2510702	ERR2510702	lineage2.2.1	it	Italy	pnca_p.ile6thr	A	E	ILE	IA6	pnca_complex.pdb
331	I6V	L1	PZA	I	I6	6	V	NA	Sensitive	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-2.761	-1.528	1.33147	-1.511	-1.35	-86	93	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	NA	NA	NA	NA	NA	24	0	0	0	0	0	0	0	-1	0	-1	0	2	2	0	-0.699341438703141	-0.394832041343669	0.048495035657311	-0.257630008525149	-0.353403141361257	-0.924731182795699	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	neutral	-0.728	-0.553	8:7	146/150	M:A:I:L:V	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	lineage1	other_mutations_pyrazinamide	VAL	SAMN02599161	SRR1173036_SRR1172709	lineage1.1.3	in	India	pnca_p.ile6val	A	E	ILE	IA6	pnca_complex.pdb
332	I6V		PZA	I	I6	6	V	NA	Other	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-2.761	-1.528	1.33147	-1.511	-1.35	-86	93	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	NA	NA	NA	NA	NA	24	0	0	0	0	0	0	0	-1	0	-1	0	2	2	0	-0.699341438703141	-0.394832041343669	0.048495035657311	-0.257630008525149	-0.353403141361257	-0.924731182795699	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	neutral	-0.728	-0.553	8:7	146/150	M:A:I:L:V	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA		other_mutations_pyrazinamide	VAL	SRR7496471	SRR7496471		us	Hawaii	pnca_p.ile6val	A	E	ILE	IA6	pnca_complex.pdb
333	I6V	L4	PZA	I	I6	6	V	NA	Pre-MDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	9.258	-2.761	-1.528	1.33147	-1.511	-1.35	-86	93	-0.6	7	7	1	0.0050761421319796	strand	4.4	11.36	NA	NA	NA	NA	NA	24	0	0	0	0	0	0	0	-1	0	-1	0	2	2	0	-0.699341438703141	-0.394832041343669	0.048495035657311	-0.257630008525149	-0.353403141361257	-0.924731182795699	-0.494233937397035	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	neutral	-0.728	-0.553	8:7	146/150	M:A:I:L:V	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	lineage4	other_mutations_pyrazinamide	VAL	SRR7496523	SRR7496523	lineage4	us	Hawaii	pnca_p.ile6val	A	E	ILE	IA6	pnca_complex.pdb
334	V7A	L4	PZA	V	V7	7	A	NA	Other	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	5.336	-0.97	-2.592	3.42668	-3.043	-1.9	64	80	-0.66	7	7	0	0	strand	1.73333333333333	11.02	7.18700589334483e-05	2.42412778478352	0.0001249735077034	0	1.03410070803344e-29	2	0	0	0	0	0	-2	0	5	0	3	2	4	6	3	-0.245694022289767	-0.669767441860465	0.124807144574188	-0.518840579710145	-0.49738219895288	0.673684210526316	-0.543657331136738	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.779	-0.615	8:7	146/150	V:I:A	-8.98740878149641	0.940032862253633	119.468044435491	-0.075228558598775	NA	4692673.51081185	0.384555509373631	1	0	0	188.544222231268	0.999999999999997	lineage4	other_mutations_pyrazinamide	ALA	ERR2229336	ERR2229336	lineage4.8	dk		pnca_p.val7ala	A	E	VAL	VA7	pnca_complex.pdb
335	V7A	L2	PZA	V	V7	7	A	NA	XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	5.336	-0.97	-2.592	3.42668	-3.043	-1.9	64	80	-0.66	7	7	0	0	strand	1.73333333333333	11.02	7.18700589334483e-05	2.42412778478352	0.0001249735077034	0	1.03410070803344e-29	2	0	0	0	0	0	-2	0	5	0	3	2	4	6	3	-0.245694022289767	-0.669767441860465	0.124807144574188	-0.518840579710145	-0.49738219895288	0.673684210526316	-0.543657331136738	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.779	-0.615	8:7	146/150	V:I:A	-8.98740878149641	0.940032862253633	119.468044435491	-0.075228558598775	NA	4692673.51081185	0.384555509373631	1	0	0	188.544222231268	0.999999999999997	lineage2	other_mutations_pyrazinamide	ALA	SRR5266560	SRR5266560	lineage2.2.1	ru	Russia	pnca_p.val7ala	A	E	VAL	VA7	pnca_complex.pdb
336	V7A	L2	PZA	V	V7	7	A	NA	XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	5.336	-0.97	-2.592	3.42668	-3.043	-1.9	64	80	-0.66	7	7	0	0	strand	1.73333333333333	11.02	7.18700589334483e-05	2.42412778478352	0.0001249735077034	0	1.03410070803344e-29	2	0	0	0	0	0	-2	0	5	0	3	2	4	6	3	-0.245694022289767	-0.669767441860465	0.124807144574188	-0.518840579710145	-0.49738219895288	0.673684210526316	-0.543657331136738	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.779	-0.615	8:7	146/150	V:I:A	-8.98740878149641	0.940032862253633	119.468044435491	-0.075228558598775	NA	4692673.51081185	0.384555509373631	1	0	0	188.544222231268	0.999999999999997	lineage2	other_mutations_pyrazinamide	ALA	ETB0089	SRR6257033	lineage2.2.1	ru	Russia:Leningrad Region	pnca_p.val7ala	A	E	VAL	VA7	pnca_complex.pdb
337	V7A	L2	PZA	V	V7	7	A	NA	XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	5.336	-0.97	-2.592	3.42668	-3.043	-1.9	64	80	-0.66	7	7	0	0	strand	1.73333333333333	11.02	7.18700589334483e-05	2.42412778478352	0.0001249735077034	0	1.03410070803344e-29	2	0	0	0	0	0	-2	0	5	0	3	2	4	6	3	-0.245694022289767	-0.669767441860465	0.124807144574188	-0.518840579710145	-0.49738219895288	0.673684210526316	-0.543657331136738	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.779	-0.615	8:7	146/150	V:I:A	-8.98740878149641	0.940032862253633	119.468044435491	-0.075228558598775	NA	4692673.51081185	0.384555509373631	1	0	0	188.544222231268	0.999999999999997	lineage2	other_mutations_pyrazinamide	ALA	SRR5266539	SRR5266539	lineage2.2.1	ru	Russia	pnca_p.val7ala	A	E	VAL	VA7	pnca_complex.pdb
338	V7A	L2	PZA	V	V7	7	A	NA	MDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	5.336	-0.97	-2.592	3.42668	-3.043	-1.9	64	80	-0.66	7	7	0	0	strand	1.73333333333333	11.02	7.18700589334483e-05	2.42412778478352	0.0001249735077034	0	1.03410070803344e-29	2	0	0	0	0	0	-2	0	5	0	3	2	4	6	3	-0.245694022289767	-0.669767441860465	0.124807144574188	-0.518840579710145	-0.49738219895288	0.673684210526316	-0.543657331136738	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.779	-0.615	8:7	146/150	V:I:A	-8.98740878149641	0.940032862253633	119.468044435491	-0.075228558598775	NA	4692673.51081185	0.384555509373631	1	0	0	188.544222231268	0.999999999999997	lineage2	other_mutations_pyrazinamide	ALA	ERR2516416	ERR2516416	lineage2.2.1.1	nl	Netherlands	pnca_p.val7ala	A	E	VAL	VA7	pnca_complex.pdb
339	V7A	L4	PZA	V	V7	7	A	NA	MDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	5.336	-0.97	-2.592	3.42668	-3.043	-1.9	64	80	-0.66	7	7	0	0	strand	1.73333333333333	11.02	7.18700589334483e-05	2.42412778478352	0.0001249735077034	0	1.03410070803344e-29	2	0	0	0	0	0	-2	0	5	0	3	2	4	6	3	-0.245694022289767	-0.669767441860465	0.124807144574188	-0.518840579710145	-0.49738219895288	0.673684210526316	-0.543657331136738	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.779	-0.615	8:7	146/150	V:I:A	-8.98740878149641	0.940032862253633	119.468044435491	-0.075228558598775	NA	4692673.51081185	0.384555509373631	1	0	0	188.544222231268	0.999999999999997	lineage4	other_mutations_pyrazinamide	ALA	ERR2707207	ERR2707207	lineage4.3.4.2	cd	Democratic Republic of Congo	pnca_p.val7ala	A	E	VAL	VA7	pnca_complex.pdb
340	V7A	L4	PZA	V	V7	7	A	NA	Pre-XDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	5.336	-0.97	-2.592	3.42668	-3.043	-1.9	64	80	-0.66	7	7	0	0	strand	1.73333333333333	11.02	7.18700589334483e-05	2.42412778478352	0.0001249735077034	0	1.03410070803344e-29	2	0	0	0	0	0	-2	0	5	0	3	2	4	6	3	-0.245694022289767	-0.669767441860465	0.124807144574188	-0.518840579710145	-0.49738219895288	0.673684210526316	-0.543657331136738	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.779	-0.615	8:7	146/150	V:I:A	-8.98740878149641	0.940032862253633	119.468044435491	-0.075228558598775	NA	4692673.51081185	0.384555509373631	1	0	0	188.544222231268	0.999999999999997	lineage4	other_mutations_pyrazinamide	ALA	SAMN02403510	SRR1167309_SRR1173718_SRR1165298_SRR1173815	lineage4.1.1.3	za	South Africa	pnca_p.val7ala	A	E	VAL	VA7	pnca_complex.pdb
341	V7A	L2	PZA	V	V7	7	A	0	MDR	OM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	5.336	-0.97	-2.592	3.42668	-3.043	-1.9	64	80	-0.66	7	7	0	0	strand	1.73333333333333	11.02	7.18700589334483e-05	2.42412778478352	0.0001249735077034	0	1.03410070803344e-29	2	0	0	0	0	0	-2	0	5	0	3	2	4	6	3	-0.245694022289767	-0.669767441860465	0.124807144574188	-0.518840579710145	-0.49738219895288	0.673684210526316	-0.543657331136738	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.779	-0.615	8:7	146/150	V:I:A	-8.98740878149641	0.940032862253633	119.468044435491	-0.075228558598775	NA	4692673.51081185	0.384555509373631	1	0	0	188.544222231268	0.999999999999997	lineage2	other_mutations_pyrazinamide	ALA	ERR2516577	ERR2516577	lineage2.2.1.1	nl	Netherlands	pnca_p.val7ala	A	E	VAL	VA7	pnca_complex.pdb
342	V7F	L2	PZA	V	V7	7	F	1	Pre-XDR	DM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	5.336	0.042	-1.877	4.86315	-2.949	-1.55	83	91	-0.66	7	7	0	0	strand	1.73333333333333	11.02	0.0002156101768003	9.70466975178797	9.70465898653049	9.70194990589383	2.29168245016684	-54	-2	0	-2	0	0	-2	0	-3	0	1	-4	-8	-6	-4	0.0188340807174887	-0.485012919896641	0.177126508788671	-0.502813299232737	-0.405759162303665	0.873684210526316	-0.543657331136738	Stabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.779	-0.615	8:7	146/150	V:I:A	2.27260607808817	0.06344559022609	1.22442760158496	1.8560559033024	0.929172866365903	208.881603004777	0.986980761010679	0.0776844925942494	1.10966566656461	0.504888890842109	570.372842410328	0.130068862702538	lineage2	dr_mutations_pyrazinamide	PHE	ERR2510561	ERR2510561	lineage2.2.1	pk	Pakistan	pnca_p.val7phe	A	E	VAL	VA7	pnca_complex.pdb
343	V7F	L4	PZA	V	V7	7	F	0	Pre-XDR	DM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	5.336	0.042	-1.877	4.86315	-2.949	-1.55	83	91	-0.66	7	7	0	0	strand	1.73333333333333	11.02	0.0002156101768003	9.70466975178797	9.70465898653049	9.70194990589383	2.29168245016684	-54	-2	0	-2	0	0	-2	0	-3	0	1	-4	-8	-6	-4	0.0188340807174887	-0.485012919896641	0.177126508788671	-0.502813299232737	-0.405759162303665	0.873684210526316	-0.543657331136738	Stabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.779	-0.615	8:7	146/150	V:I:A	2.27260607808817	0.06344559022609	1.22442760158496	1.8560559033024	0.929172866365903	208.881603004777	0.986980761010679	0.0776844925942494	1.10966566656461	0.504888890842109	570.372842410328	0.130068862702538	lineage4	dr_mutations_pyrazinamide	PHE	ERR2510453	ERR2510453	lineage4.8	pk	Pakistan	pnca_p.val7phe	A	E	VAL	VA7	pnca_complex.pdb
344	V7F	L2	PZA	V	V7	7	F	NA	XDR	DM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	5.336	0.042	-1.877	4.86315	-2.949	-1.55	83	91	-0.66	7	7	0	0	strand	1.73333333333333	11.02	0.0002156101768003	9.70466975178797	9.70465898653049	9.70194990589383	2.29168245016684	-54	-2	0	-2	0	0	-2	0	-3	0	1	-4	-8	-6	-4	0.0188340807174887	-0.485012919896641	0.177126508788671	-0.502813299232737	-0.405759162303665	0.873684210526316	-0.543657331136738	Stabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.779	-0.615	8:7	146/150	V:I:A	2.27260607808817	0.06344559022609	1.22442760158496	1.8560559033024	0.929172866365903	208.881603004777	0.986980761010679	0.0776844925942494	1.10966566656461	0.504888890842109	570.372842410328	0.130068862702538	lineage2	dr_mutations_pyrazinamide	PHE	SRR671815,BGI_SH311	SRR671815	lineage2.2.1	cn	China	pnca_p.val7phe	A	E	VAL	VA7	pnca_complex.pdb
345	V7F	L4	PZA	V	V7	7	F	1	Pre-XDR	DM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	5.336	0.042	-1.877	4.86315	-2.949	-1.55	83	91	-0.66	7	7	0	0	strand	1.73333333333333	11.02	0.0002156101768003	9.70466975178797	9.70465898653049	9.70194990589383	2.29168245016684	-54	-2	0	-2	0	0	-2	0	-3	0	1	-4	-8	-6	-4	0.0188340807174887	-0.485012919896641	0.177126508788671	-0.502813299232737	-0.405759162303665	0.873684210526316	-0.543657331136738	Stabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.779	-0.615	8:7	146/150	V:I:A	2.27260607808817	0.06344559022609	1.22442760158496	1.8560559033024	0.929172866365903	208.881603004777	0.986980761010679	0.0776844925942494	1.10966566656461	0.504888890842109	570.372842410328	0.130068862702538	lineage4	dr_mutations_pyrazinamide	PHE	ERR2516523	ERR2516523	lineage4.1.1	pe	Peru	pnca_p.val7phe	A	E	VAL	VA7	pnca_complex.pdb
346	V7G	L2	PZA	V	V7	7	G	NA	XDR	DM	hydrophobic	hydrophobic	non-polar	neutral	non-polar	non-polar	5.336	-1.062	-3.114	5.26226	-4.33	-2.58	86	91	-0.66	7	7	0	0	strand	1.73333333333333	11.02	0.001293661060802	39.0452814219213	39.0452813634446	39.0430804499264	60.5607562088978	12	0	0	0	0	0	-2	0	3	0	1	2	8	11	21	-0.268996960486322	-0.804651162790698	0.191662963745365	-0.738277919863598	-0.675392670157068	0.905263157894737	-0.543657331136738	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.779	-0.615	8:7	146/150	V:I:A	3.6647220332212	1.03849290922087e-06	0.750321763717271	4.88420063289289	11.103639297077	247.090478887866	1.59156855738766	5.52264644232101e-11	10.2578527592503	9.16748833639401	349.97982252054	7.13421964779937e-15	lineage2	dr_mutations_pyrazinamide	GLY	SAMN02628499	SRR1172711_SRR1173722	lineage2.2.1	ir	Iran	pnca_p.val7gly	A	E	VAL	VA7	pnca_complex.pdb
347	V7G	L2	PZA	V	V7	7	G	1	Pre-XDR	DM	hydrophobic	hydrophobic	non-polar	neutral	non-polar	non-polar	5.336	-1.062	-3.114	5.26226	-4.33	-2.58	86	91	-0.66	7	7	0	0	strand	1.73333333333333	11.02	0.001293661060802	39.0452814219213	39.0452813634446	39.0430804499264	60.5607562088978	12	0	0	0	0	0	-2	0	3	0	1	2	8	11	21	-0.268996960486322	-0.804651162790698	0.191662963745365	-0.738277919863598	-0.675392670157068	0.905263157894737	-0.543657331136738	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.779	-0.615	8:7	146/150	V:I:A	3.6647220332212	1.03849290922087e-06	0.750321763717271	4.88420063289289	11.103639297077	247.090478887866	1.59156855738766	5.52264644232101e-11	10.2578527592503	9.16748833639401	349.97982252054	7.13421964779937e-15	lineage2	dr_mutations_pyrazinamide	GLY	MDR_22242	SRR6824593	lineage2.2.1	cn	China: Fengjie County, Chongqing	pnca_p.val7gly	A	E	VAL	VA7	pnca_complex.pdb
348	V7G	L2	PZA	V	V7	7	G	1	Pre-MDR	DM	hydrophobic	hydrophobic	non-polar	neutral	non-polar	non-polar	5.336	-1.062	-3.114	5.26226	-4.33	-2.58	86	91	-0.66	7	7	0	0	strand	1.73333333333333	11.02	0.001293661060802	39.0452814219213	39.0452813634446	39.0430804499264	60.5607562088978	12	0	0	0	0	0	-2	0	3	0	1	2	8	11	21	-0.268996960486322	-0.804651162790698	0.191662963745365	-0.738277919863598	-0.675392670157068	0.905263157894737	-0.543657331136738	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.779	-0.615	8:7	146/150	V:I:A	3.6647220332212	1.03849290922087e-06	0.750321763717271	4.88420063289289	11.103639297077	247.090478887866	1.59156855738766	5.52264644232101e-11	10.2578527592503	9.16748833639401	349.97982252054	7.13421964779937e-15	lineage2	dr_mutations_pyrazinamide	GLY	ERR144542,1769Z-sc-2012-02-21T11:37:21Z-1364779	ERR144542	lineage2.2.1	ru	Russia,Samara	pnca_p.val7gly	A	E	VAL	VA7	pnca_complex.pdb
349	V7G	L2	PZA	V	V7	7	G	1	MDR	DM	hydrophobic	hydrophobic	non-polar	neutral	non-polar	non-polar	5.336	-1.062	-3.114	5.26226	-4.33	-2.58	86	91	-0.66	7	7	0	0	strand	1.73333333333333	11.02	0.001293661060802	39.0452814219213	39.0452813634446	39.0430804499264	60.5607562088978	12	0	0	0	0	0	-2	0	3	0	1	2	8	11	21	-0.268996960486322	-0.804651162790698	0.191662963745365	-0.738277919863598	-0.675392670157068	0.905263157894737	-0.543657331136738	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.779	-0.615	8:7	146/150	V:I:A	3.6647220332212	1.03849290922087e-06	0.750321763717271	4.88420063289289	11.103639297077	247.090478887866	1.59156855738766	5.52264644232101e-11	10.2578527592503	9.16748833639401	349.97982252054	7.13421964779937e-15	lineage2	dr_mutations_pyrazinamide	GLY	ERR2041800	ERR2041800	lineage2.2.1	rs	Serbia	pnca_p.val7gly	A	E	VAL	VA7	pnca_complex.pdb
350	V7G	L2	PZA	V	V7	7	G	NA	MDR	DM	hydrophobic	hydrophobic	non-polar	neutral	non-polar	non-polar	5.336	-1.062	-3.114	5.26226	-4.33	-2.58	86	91	-0.66	7	7	0	0	strand	1.73333333333333	11.02	0.001293661060802	39.0452814219213	39.0452813634446	39.0430804499264	60.5607562088978	12	0	0	0	0	0	-2	0	3	0	1	2	8	11	21	-0.268996960486322	-0.804651162790698	0.191662963745365	-0.738277919863598	-0.675392670157068	0.905263157894737	-0.543657331136738	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.779	-0.615	8:7	146/150	V:I:A	3.6647220332212	1.03849290922087e-06	0.750321763717271	4.88420063289289	11.103639297077	247.090478887866	1.59156855738766	5.52264644232101e-11	10.2578527592503	9.16748833639401	349.97982252054	7.13421964779937e-15	lineage2	dr_mutations_pyrazinamide	GLY	SRR5709871	SRR5709871	lineage2.2.1	th	Thailand	pnca_p.val7gly	A	E	VAL	VA7	pnca_complex.pdb
351	V7G	L2	PZA	V	V7	7	G	NA	MDR	DM	hydrophobic	hydrophobic	non-polar	neutral	non-polar	non-polar	5.336	-1.062	-3.114	5.26226	-4.33	-2.58	86	91	-0.66	7	7	0	0	strand	1.73333333333333	11.02	0.001293661060802	39.0452814219213	39.0452813634446	39.0430804499264	60.5607562088978	12	0	0	0	0	0	-2	0	3	0	1	2	8	11	21	-0.268996960486322	-0.804651162790698	0.191662963745365	-0.738277919863598	-0.675392670157068	0.905263157894737	-0.543657331136738	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.779	-0.615	8:7	146/150	V:I:A	3.6647220332212	1.03849290922087e-06	0.750321763717271	4.88420063289289	11.103639297077	247.090478887866	1.59156855738766	5.52264644232101e-11	10.2578527592503	9.16748833639401	349.97982252054	7.13421964779937e-15	lineage2	dr_mutations_pyrazinamide	GLY	SRS797250	SRR1723776	lineage2.2.1	cn	China:Heilongjiang	pnca_p.val7gly	A	E	VAL	VA7	pnca_complex.pdb
352	V7G	L2	PZA	V	V7	7	G	1	Pre-MDR	DM	hydrophobic	hydrophobic	non-polar	neutral	non-polar	non-polar	5.336	-1.062	-3.114	5.26226	-4.33	-2.58	86	91	-0.66	7	7	0	0	strand	1.73333333333333	11.02	0.001293661060802	39.0452814219213	39.0452813634446	39.0430804499264	60.5607562088978	12	0	0	0	0	0	-2	0	3	0	1	2	8	11	21	-0.268996960486322	-0.804651162790698	0.191662963745365	-0.738277919863598	-0.675392670157068	0.905263157894737	-0.543657331136738	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.779	-0.615	8:7	146/150	V:I:A	3.6647220332212	1.03849290922087e-06	0.750321763717271	4.88420063289289	11.103639297077	247.090478887866	1.59156855738766	5.52264644232101e-11	10.2578527592503	9.16748833639401	349.97982252054	7.13421964779937e-15	lineage2	dr_mutations_pyrazinamide	GLY	0153S-sc-2012-02-09T18:55:34Z-1355148,ERR133815	ERR133815	lineage2.2.1	ru	Russia,Samara	pnca_p.val7gly	A	E	VAL	VA7	pnca_complex.pdb
353	V7G	L2	PZA	V	V7	7	G	1	MDR	DM	hydrophobic	hydrophobic	non-polar	neutral	non-polar	non-polar	5.336	-1.062	-3.114	5.26226	-4.33	-2.58	86	91	-0.66	7	7	0	0	strand	1.73333333333333	11.02	0.001293661060802	39.0452814219213	39.0452813634446	39.0430804499264	60.5607562088978	12	0	0	0	0	0	-2	0	3	0	1	2	8	11	21	-0.268996960486322	-0.804651162790698	0.191662963745365	-0.738277919863598	-0.675392670157068	0.905263157894737	-0.543657331136738	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.779	-0.615	8:7	146/150	V:I:A	3.6647220332212	1.03849290922087e-06	0.750321763717271	4.88420063289289	11.103639297077	247.090478887866	1.59156855738766	5.52264644232101e-11	10.2578527592503	9.16748833639401	349.97982252054	7.13421964779937e-15	lineage2	dr_mutations_pyrazinamide	GLY	ERR2041716	ERR2041716	lineage2.2.1	rs	Serbia	pnca_p.val7gly	A	E	VAL	VA7	pnca_complex.pdb
354	V7G	L2	PZA	V	V7	7	G	NA	XDR	DM	hydrophobic	hydrophobic	non-polar	neutral	non-polar	non-polar	5.336	-1.062	-3.114	5.26226	-4.33	-2.58	86	91	-0.66	7	7	0	0	strand	1.73333333333333	11.02	0.001293661060802	39.0452814219213	39.0452813634446	39.0430804499264	60.5607562088978	12	0	0	0	0	0	-2	0	3	0	1	2	8	11	21	-0.268996960486322	-0.804651162790698	0.191662963745365	-0.738277919863598	-0.675392670157068	0.905263157894737	-0.543657331136738	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.779	-0.615	8:7	146/150	V:I:A	3.6647220332212	1.03849290922087e-06	0.750321763717271	4.88420063289289	11.103639297077	247.090478887866	1.59156855738766	5.52264644232101e-11	10.2578527592503	9.16748833639401	349.97982252054	7.13421964779937e-15	lineage2	dr_mutations_pyrazinamide	GLY	SAMN02628498	SRR1173393_SRR1174307	lineage2.2.1	ir	Iran	pnca_p.val7gly	A	E	VAL	VA7	pnca_complex.pdb
355	V7G	L2	PZA	V	V7	7	G	1	Pre-XDR	DM	hydrophobic	hydrophobic	non-polar	neutral	non-polar	non-polar	5.336	-1.062	-3.114	5.26226	-4.33	-2.58	86	91	-0.66	7	7	0	0	strand	1.73333333333333	11.02	0.001293661060802	39.0452814219213	39.0452813634446	39.0430804499264	60.5607562088978	12	0	0	0	0	0	-2	0	3	0	1	2	8	11	21	-0.268996960486322	-0.804651162790698	0.191662963745365	-0.738277919863598	-0.675392670157068	0.905263157894737	-0.543657331136738	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.779	-0.615	8:7	146/150	V:I:A	3.6647220332212	1.03849290922087e-06	0.750321763717271	4.88420063289289	11.103639297077	247.090478887866	1.59156855738766	5.52264644232101e-11	10.2578527592503	9.16748833639401	349.97982252054	7.13421964779937e-15	lineage2	dr_mutations_pyrazinamide	GLY	ERR228043,2294V-sc-2012-10-11T13:38:29Z-1494207	ERR228043	lineage2.2.1	ru	Russia,Samara	pnca_p.val7gly	A	E	VAL	VA7	pnca_complex.pdb
356	V7G	L4	PZA	V	V7	7	G	NA	Pre-XDR	DM	hydrophobic	hydrophobic	non-polar	neutral	non-polar	non-polar	5.336	-1.062	-3.114	5.26226	-4.33	-2.58	86	91	-0.66	7	7	0	0	strand	1.73333333333333	11.02	0.001293661060802	39.0452814219213	39.0452813634446	39.0430804499264	60.5607562088978	12	0	0	0	0	0	-2	0	3	0	1	2	8	11	21	-0.268996960486322	-0.804651162790698	0.191662963745365	-0.738277919863598	-0.675392670157068	0.905263157894737	-0.543657331136738	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.779	-0.615	8:7	146/150	V:I:A	3.6647220332212	1.03849290922087e-06	0.750321763717271	4.88420063289289	11.103639297077	247.090478887866	1.59156855738766	5.52264644232101e-11	10.2578527592503	9.16748833639401	349.97982252054	7.13421964779937e-15	lineage4	dr_mutations_pyrazinamide	GLY	SAMN02231161	SRR1049969_SRR1049970_SRR998773_SRR998774_SRR998772_SRR998775	lineage4.1	ml	Mali	pnca_p.val7gly	A	E	VAL	VA7	pnca_complex.pdb
357	V7G	L2	PZA	V	V7	7	G	NA	MDR	DM	hydrophobic	hydrophobic	non-polar	neutral	non-polar	non-polar	5.336	-1.062	-3.114	5.26226	-4.33	-2.58	86	91	-0.66	7	7	0	0	strand	1.73333333333333	11.02	0.001293661060802	39.0452814219213	39.0452813634446	39.0430804499264	60.5607562088978	12	0	0	0	0	0	-2	0	3	0	1	2	8	11	21	-0.268996960486322	-0.804651162790698	0.191662963745365	-0.738277919863598	-0.675392670157068	0.905263157894737	-0.543657331136738	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.779	-0.615	8:7	146/150	V:I:A	3.6647220332212	1.03849290922087e-06	0.750321763717271	4.88420063289289	11.103639297077	247.090478887866	1.59156855738766	5.52264644232101e-11	10.2578527592503	9.16748833639401	349.97982252054	7.13421964779937e-15	lineage2	dr_mutations_pyrazinamide	GLY	0738D-sc-2011-10-12T14:59:45Z-1289190,ERR117456	ERR117456	lineage2.2.1	ru	Russia	pnca_p.val7gly	A	E	VAL	VA7	pnca_complex.pdb
358	V7G	L2	PZA	V	V7	7	G	1	MDR	DM	hydrophobic	hydrophobic	non-polar	neutral	non-polar	non-polar	5.336	-1.062	-3.114	5.26226	-4.33	-2.58	86	91	-0.66	7	7	0	0	strand	1.73333333333333	11.02	0.001293661060802	39.0452814219213	39.0452813634446	39.0430804499264	60.5607562088978	12	0	0	0	0	0	-2	0	3	0	1	2	8	11	21	-0.268996960486322	-0.804651162790698	0.191662963745365	-0.738277919863598	-0.675392670157068	0.905263157894737	-0.543657331136738	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.779	-0.615	8:7	146/150	V:I:A	3.6647220332212	1.03849290922087e-06	0.750321763717271	4.88420063289289	11.103639297077	247.090478887866	1.59156855738766	5.52264644232101e-11	10.2578527592503	9.16748833639401	349.97982252054	7.13421964779937e-15	lineage2	dr_mutations_pyrazinamide	GLY	ERR2200148	ERR2200148	lineage2.2.1	rs	Serbia	pnca_p.val7gly	A	E	VAL	VA7	pnca_complex.pdb
359	V7G	L2	PZA	V	V7	7	G	1	MDR	DM	hydrophobic	hydrophobic	non-polar	neutral	non-polar	non-polar	5.336	-1.062	-3.114	5.26226	-4.33	-2.58	86	91	-0.66	7	7	0	0	strand	1.73333333333333	11.02	0.001293661060802	39.0452814219213	39.0452813634446	39.0430804499264	60.5607562088978	12	0	0	0	0	0	-2	0	3	0	1	2	8	11	21	-0.268996960486322	-0.804651162790698	0.191662963745365	-0.738277919863598	-0.675392670157068	0.905263157894737	-0.543657331136738	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.779	-0.615	8:7	146/150	V:I:A	3.6647220332212	1.03849290922087e-06	0.750321763717271	4.88420063289289	11.103639297077	247.090478887866	1.59156855738766	5.52264644232101e-11	10.2578527592503	9.16748833639401	349.97982252054	7.13421964779937e-15	lineage2	dr_mutations_pyrazinamide	GLY	ERR2041695	ERR2041695	lineage2.2.1	rs	Serbia	pnca_p.val7gly	A	E	VAL	VA7	pnca_complex.pdb
360	V7G	L4	PZA	V	V7	7	G	1	Pre-XDR	DM	hydrophobic	hydrophobic	non-polar	neutral	non-polar	non-polar	5.336	-1.062	-3.114	5.26226	-4.33	-2.58	86	91	-0.66	7	7	0	0	strand	1.73333333333333	11.02	0.001293661060802	39.0452814219213	39.0452813634446	39.0430804499264	60.5607562088978	12	0	0	0	0	0	-2	0	3	0	1	2	8	11	21	-0.268996960486322	-0.804651162790698	0.191662963745365	-0.738277919863598	-0.675392670157068	0.905263157894737	-0.543657331136738	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.779	-0.615	8:7	146/150	V:I:A	3.6647220332212	1.03849290922087e-06	0.750321763717271	4.88420063289289	11.103639297077	247.090478887866	1.59156855738766	5.52264644232101e-11	10.2578527592503	9.16748833639401	349.97982252054	7.13421964779937e-15	lineage4	dr_mutations_pyrazinamide	GLY	ERS2592788	ERR2677442	lineage4.2.2.1	de	Germany	pnca_p.val7gly	A	E	VAL	VA7	pnca_complex.pdb
361	V7G	L2	PZA	V	V7	7	G	1	MDR	DM	hydrophobic	hydrophobic	non-polar	neutral	non-polar	non-polar	5.336	-1.062	-3.114	5.26226	-4.33	-2.58	86	91	-0.66	7	7	0	0	strand	1.73333333333333	11.02	0.001293661060802	39.0452814219213	39.0452813634446	39.0430804499264	60.5607562088978	12	0	0	0	0	0	-2	0	3	0	1	2	8	11	21	-0.268996960486322	-0.804651162790698	0.191662963745365	-0.738277919863598	-0.675392670157068	0.905263157894737	-0.543657331136738	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.779	-0.615	8:7	146/150	V:I:A	3.6647220332212	1.03849290922087e-06	0.750321763717271	4.88420063289289	11.103639297077	247.090478887866	1.59156855738766	5.52264644232101e-11	10.2578527592503	9.16748833639401	349.97982252054	7.13421964779937e-15	lineage2	dr_mutations_pyrazinamide	GLY	MDR_8213	SRR6824586	lineage2.2.1	cn	China: Bin County, Harbin City, Heilongjiang Province	pnca_p.val7gly	A	E	VAL	VA7	pnca_complex.pdb
362	V7G	L2	PZA	V	V7	7	G	1	MDR	DM	hydrophobic	hydrophobic	non-polar	neutral	non-polar	non-polar	5.336	-1.062	-3.114	5.26226	-4.33	-2.58	86	91	-0.66	7	7	0	0	strand	1.73333333333333	11.02	0.001293661060802	39.0452814219213	39.0452813634446	39.0430804499264	60.5607562088978	12	0	0	0	0	0	-2	0	3	0	1	2	8	11	21	-0.268996960486322	-0.804651162790698	0.191662963745365	-0.738277919863598	-0.675392670157068	0.905263157894737	-0.543657331136738	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.779	-0.615	8:7	146/150	V:I:A	3.6647220332212	1.03849290922087e-06	0.750321763717271	4.88420063289289	11.103639297077	247.090478887866	1.59156855738766	5.52264644232101e-11	10.2578527592503	9.16748833639401	349.97982252054	7.13421964779937e-15	lineage2	dr_mutations_pyrazinamide	GLY	ERR2510712	ERR2510712	lineage2.2.1	it	Italy	pnca_p.val7gly	A	E	VAL	VA7	pnca_complex.pdb
363	V7G	L2	PZA	V	V7	7	G	1	MDR	DM	hydrophobic	hydrophobic	non-polar	neutral	non-polar	non-polar	5.336	-1.062	-3.114	5.26226	-4.33	-2.58	86	91	-0.66	7	7	0	0	strand	1.73333333333333	11.02	0.001293661060802	39.0452814219213	39.0452813634446	39.0430804499264	60.5607562088978	12	0	0	0	0	0	-2	0	3	0	1	2	8	11	21	-0.268996960486322	-0.804651162790698	0.191662963745365	-0.738277919863598	-0.675392670157068	0.905263157894737	-0.543657331136738	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.779	-0.615	8:7	146/150	V:I:A	3.6647220332212	1.03849290922087e-06	0.750321763717271	4.88420063289289	11.103639297077	247.090478887866	1.59156855738766	5.52264644232101e-11	10.2578527592503	9.16748833639401	349.97982252054	7.13421964779937e-15	lineage2	dr_mutations_pyrazinamide	GLY	ERR2516243	ERR2516243	lineage2.2.1	be	Belgium	pnca_p.val7gly	A	E	VAL	VA7	pnca_complex.pdb
364	V7G	L2	PZA	V	V7	7	G	1	Pre-MDR	DM	hydrophobic	hydrophobic	non-polar	neutral	non-polar	non-polar	5.336	-1.062	-3.114	5.26226	-4.33	-2.58	86	91	-0.66	7	7	0	0	strand	1.73333333333333	11.02	0.001293661060802	39.0452814219213	39.0452813634446	39.0430804499264	60.5607562088978	12	0	0	0	0	0	-2	0	3	0	1	2	8	11	21	-0.268996960486322	-0.804651162790698	0.191662963745365	-0.738277919863598	-0.675392670157068	0.905263157894737	-0.543657331136738	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.779	-0.615	8:7	146/150	V:I:A	3.6647220332212	1.03849290922087e-06	0.750321763717271	4.88420063289289	11.103639297077	247.090478887866	1.59156855738766	5.52264644232101e-11	10.2578527592503	9.16748833639401	349.97982252054	7.13421964779937e-15	lineage2	dr_mutations_pyrazinamide	GLY	ERR133900,0667B-sc-2012-02-09T18:56:39Z-1355233	ERR133900	lineage2.2.1	ru	Russia,Samara	pnca_p.val7gly	A	E	VAL	VA7	pnca_complex.pdb
365	V7G	L2	PZA	V	V7	7	G	NA	MDR	DM	hydrophobic	hydrophobic	non-polar	neutral	non-polar	non-polar	5.336	-1.062	-3.114	5.26226	-4.33	-2.58	86	91	-0.66	7	7	0	0	strand	1.73333333333333	11.02	0.001293661060802	39.0452814219213	39.0452813634446	39.0430804499264	60.5607562088978	12	0	0	0	0	0	-2	0	3	0	1	2	8	11	21	-0.268996960486322	-0.804651162790698	0.191662963745365	-0.738277919863598	-0.675392670157068	0.905263157894737	-0.543657331136738	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.779	-0.615	8:7	146/150	V:I:A	3.6647220332212	1.03849290922087e-06	0.750321763717271	4.88420063289289	11.103639297077	247.090478887866	1.59156855738766	5.52264644232101e-11	10.2578527592503	9.16748833639401	349.97982252054	7.13421964779937e-15	lineage2	dr_mutations_pyrazinamide	GLY	BGI_142,SRR671721	SRR671721	lineage2.2.1	cn	China	pnca_p.val7gly	A	E	VAL	VA7	pnca_complex.pdb
366	V7G	L2	PZA	V	V7	7	G	0	Pre-MDR	DM	hydrophobic	hydrophobic	non-polar	neutral	non-polar	non-polar	5.336	-1.062	-3.114	5.26226	-4.33	-2.58	86	91	-0.66	7	7	0	0	strand	1.73333333333333	11.02	0.001293661060802	39.0452814219213	39.0452813634446	39.0430804499264	60.5607562088978	12	0	0	0	0	0	-2	0	3	0	1	2	8	11	21	-0.268996960486322	-0.804651162790698	0.191662963745365	-0.738277919863598	-0.675392670157068	0.905263157894737	-0.543657331136738	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.779	-0.615	8:7	146/150	V:I:A	3.6647220332212	1.03849290922087e-06	0.750321763717271	4.88420063289289	11.103639297077	247.090478887866	1.59156855738766	5.52264644232101e-11	10.2578527592503	9.16748833639401	349.97982252054	7.13421964779937e-15	lineage2	dr_mutations_pyrazinamide	GLY	ERR133888,0589R-sc-2012-02-09T18:56:26Z-1355221	ERR133888	lineage2.2.1	ru	Russia,Samara	pnca_p.val7gly	A	E	VAL	VA7	pnca_complex.pdb
367	V7G	L2	PZA	V	V7	7	G	1	MDR	DM	hydrophobic	hydrophobic	non-polar	neutral	non-polar	non-polar	5.336	-1.062	-3.114	5.26226	-4.33	-2.58	86	91	-0.66	7	7	0	0	strand	1.73333333333333	11.02	0.001293661060802	39.0452814219213	39.0452813634446	39.0430804499264	60.5607562088978	12	0	0	0	0	0	-2	0	3	0	1	2	8	11	21	-0.268996960486322	-0.804651162790698	0.191662963745365	-0.738277919863598	-0.675392670157068	0.905263157894737	-0.543657331136738	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.779	-0.615	8:7	146/150	V:I:A	3.6647220332212	1.03849290922087e-06	0.750321763717271	4.88420063289289	11.103639297077	247.090478887866	1.59156855738766	5.52264644232101e-11	10.2578527592503	9.16748833639401	349.97982252054	7.13421964779937e-15	lineage2	dr_mutations_pyrazinamide	GLY	ERR2041704	ERR2041704	lineage2.2.1	rs	Serbia	pnca_p.val7gly	A	E	VAL	VA7	pnca_complex.pdb
368	V7G	L2	PZA	V	V7	7	G	NA	XDR	DM	hydrophobic	hydrophobic	non-polar	neutral	non-polar	non-polar	5.336	-1.062	-3.114	5.26226	-4.33	-2.58	86	91	-0.66	7	7	0	0	strand	1.73333333333333	11.02	0.001293661060802	39.0452814219213	39.0452813634446	39.0430804499264	60.5607562088978	12	0	0	0	0	0	-2	0	3	0	1	2	8	11	21	-0.268996960486322	-0.804651162790698	0.191662963745365	-0.738277919863598	-0.675392670157068	0.905263157894737	-0.543657331136738	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.779	-0.615	8:7	146/150	V:I:A	3.6647220332212	1.03849290922087e-06	0.750321763717271	4.88420063289289	11.103639297077	247.090478887866	1.59156855738766	5.52264644232101e-11	10.2578527592503	9.16748833639401	349.97982252054	7.13421964779937e-15	lineage2	dr_mutations_pyrazinamide	GLY	ERR144591	ERR144591	lineage2.2.1	ru	Russia	pnca_p.val7gly	A	E	VAL	VA7	pnca_complex.pdb
369	V7G	L2	PZA	V	V7	7	G	0	MDR	DM	hydrophobic	hydrophobic	non-polar	neutral	non-polar	non-polar	5.336	-1.062	-3.114	5.26226	-4.33	-2.58	86	91	-0.66	7	7	0	0	strand	1.73333333333333	11.02	0.001293661060802	39.0452814219213	39.0452813634446	39.0430804499264	60.5607562088978	12	0	0	0	0	0	-2	0	3	0	1	2	8	11	21	-0.268996960486322	-0.804651162790698	0.191662963745365	-0.738277919863598	-0.675392670157068	0.905263157894737	-0.543657331136738	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.779	-0.615	8:7	146/150	V:I:A	3.6647220332212	1.03849290922087e-06	0.750321763717271	4.88420063289289	11.103639297077	247.090478887866	1.59156855738766	5.52264644232101e-11	10.2578527592503	9.16748833639401	349.97982252054	7.13421964779937e-15	lineage2	dr_mutations_pyrazinamide	GLY	ERR2041685	ERR2041685	lineage2.2.1	rs	Serbia	pnca_p.val7gly	A	E	VAL	VA7	pnca_complex.pdb
370	V7G	L2	PZA	V	V7	7	G	1	MDR	DM	hydrophobic	hydrophobic	non-polar	neutral	non-polar	non-polar	5.336	-1.062	-3.114	5.26226	-4.33	-2.58	86	91	-0.66	7	7	0	0	strand	1.73333333333333	11.02	0.001293661060802	39.0452814219213	39.0452813634446	39.0430804499264	60.5607562088978	12	0	0	0	0	0	-2	0	3	0	1	2	8	11	21	-0.268996960486322	-0.804651162790698	0.191662963745365	-0.738277919863598	-0.675392670157068	0.905263157894737	-0.543657331136738	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.779	-0.615	8:7	146/150	V:I:A	3.6647220332212	1.03849290922087e-06	0.750321763717271	4.88420063289289	11.103639297077	247.090478887866	1.59156855738766	5.52264644232101e-11	10.2578527592503	9.16748833639401	349.97982252054	7.13421964779937e-15	lineage2	dr_mutations_pyrazinamide	GLY	ERR2041691	ERR2041691	lineage2.2.1	rs	Serbia	pnca_p.val7gly	A	E	VAL	VA7	pnca_complex.pdb
371	V7G	L2	PZA	V	V7	7	G	1	MDR	DM	hydrophobic	hydrophobic	non-polar	neutral	non-polar	non-polar	5.336	-1.062	-3.114	5.26226	-4.33	-2.58	86	91	-0.66	7	7	0	0	strand	1.73333333333333	11.02	0.001293661060802	39.0452814219213	39.0452813634446	39.0430804499264	60.5607562088978	12	0	0	0	0	0	-2	0	3	0	1	2	8	11	21	-0.268996960486322	-0.804651162790698	0.191662963745365	-0.738277919863598	-0.675392670157068	0.905263157894737	-0.543657331136738	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.779	-0.615	8:7	146/150	V:I:A	3.6647220332212	1.03849290922087e-06	0.750321763717271	4.88420063289289	11.103639297077	247.090478887866	1.59156855738766	5.52264644232101e-11	10.2578527592503	9.16748833639401	349.97982252054	7.13421964779937e-15	lineage2	dr_mutations_pyrazinamide	GLY	ERR2041706	ERR2041706	lineage2.2.1	rs	Serbia	pnca_p.val7gly	A	E	VAL	VA7	pnca_complex.pdb
372	V7G	L2	PZA	V	V7	7	G	NA	XDR	DM	hydrophobic	hydrophobic	non-polar	neutral	non-polar	non-polar	5.336	-1.062	-3.114	5.26226	-4.33	-2.58	86	91	-0.66	7	7	0	0	strand	1.73333333333333	11.02	0.001293661060802	39.0452814219213	39.0452813634446	39.0430804499264	60.5607562088978	12	0	0	0	0	0	-2	0	3	0	1	2	8	11	21	-0.268996960486322	-0.804651162790698	0.191662963745365	-0.738277919863598	-0.675392670157068	0.905263157894737	-0.543657331136738	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.779	-0.615	8:7	146/150	V:I:A	3.6647220332212	1.03849290922087e-06	0.750321763717271	4.88420063289289	11.103639297077	247.090478887866	1.59156855738766	5.52264644232101e-11	10.2578527592503	9.16748833639401	349.97982252054	7.13421964779937e-15	lineage2	dr_mutations_pyrazinamide	GLY	SAMN02628501	SRR1173446_SRR1173842	lineage2.2.1	ir	Iran	pnca_p.val7gly	A	E	VAL	VA7	pnca_complex.pdb
373	V7G	L2	PZA	V	V7	7	G	NA	XDR	DM	hydrophobic	hydrophobic	non-polar	neutral	non-polar	non-polar	5.336	-1.062	-3.114	5.26226	-4.33	-2.58	86	91	-0.66	7	7	0	0	strand	1.73333333333333	11.02	0.001293661060802	39.0452814219213	39.0452813634446	39.0430804499264	60.5607562088978	12	0	0	0	0	0	-2	0	3	0	1	2	8	11	21	-0.268996960486322	-0.804651162790698	0.191662963745365	-0.738277919863598	-0.675392670157068	0.905263157894737	-0.543657331136738	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.779	-0.615	8:7	146/150	V:I:A	3.6647220332212	1.03849290922087e-06	0.750321763717271	4.88420063289289	11.103639297077	247.090478887866	1.59156855738766	5.52264644232101e-11	10.2578527592503	9.16748833639401	349.97982252054	7.13421964779937e-15	lineage2	dr_mutations_pyrazinamide	GLY	SAMN02628500	SRR1173750_SRR1173675	lineage2.2.1	ir	Iran	pnca_p.val7gly	A	E	VAL	VA7	pnca_complex.pdb
374	V7G	L2	PZA	V	V7	7	G	NA	XDR	DM	hydrophobic	hydrophobic	non-polar	neutral	non-polar	non-polar	5.336	-1.062	-3.114	5.26226	-4.33	-2.58	86	91	-0.66	7	7	0	0	strand	1.73333333333333	11.02	0.001293661060802	39.0452814219213	39.0452813634446	39.0430804499264	60.5607562088978	12	0	0	0	0	0	-2	0	3	0	1	2	8	11	21	-0.268996960486322	-0.804651162790698	0.191662963745365	-0.738277919863598	-0.675392670157068	0.905263157894737	-0.543657331136738	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.779	-0.615	8:7	146/150	V:I:A	3.6647220332212	1.03849290922087e-06	0.750321763717271	4.88420063289289	11.103639297077	247.090478887866	1.59156855738766	5.52264644232101e-11	10.2578527592503	9.16748833639401	349.97982252054	7.13421964779937e-15	lineage2	dr_mutations_pyrazinamide	GLY	SAMN02628502	SRR1173792_SRR1173628	lineage2.2.1	ir	Iran	pnca_p.val7gly	A	E	VAL	VA7	pnca_complex.pdb
375	V7I	L4	PZA	V	V7	7	I	NA	MDR	DM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	5.336	-0.635	-0.898	-1.10338	-0.738	-0.73	46	71	-0.66	7	7	0	0	strand	1.73333333333333	11.02	NA	NA	NA	NA	NA	-24	0	0	0	0	0	-2	0	-4	0	2	-7	0	2	-2	-0.160840932117528	-0.232041343669251	-0.212139506267784	-0.125831202046036	-0.19109947643979	0.484210526315789	-0.543657331136738	Destabilising	Destabilising	Stabilising	Destabilising	Destabilising	effect	-0.779	-0.615	8:7	146/150	V:I:A	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	lineage4	dr_mutations_pyrazinamide	ILE	SAMN02586003	SRR1196479_SRR1175056_SRR1184351_SRR1172851	lineage4.3.4.2	za	South Africa	pnca_p.val7ile	A	E	VAL	VA7	pnca_complex.pdb
376	V7L	L4	PZA	V	V7	7	L	1	Pre-XDR	DM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	5.336	-0.589	-1.137	-0.847275	-2.289	-0.99	83	91	-0.66	7	7	0	0	strand	1.73333333333333	11.02	0.0009343107661348	10.9471518987342	10.9471289278841	10.9440461901209	21.4040928993518	-26	0	0	0	0	0	-2	0	-3	0	1	-4	-2	-2	2	-0.14918946301925	-0.293798449612403	-0.162899907713605	-0.390281329923274	-0.259162303664921	0.873684210526316	-0.543657331136738	Destabilising	Destabilising	Stabilising	Destabilising	Destabilising	effect	-0.779	-0.615	8:7	146/150	V:I:A	2.39307722351576	6.83262964849249e-05	0.600967660910521	3.98203993188257	3.56185012264106	40.4315613280321	1.03930114423982	4.53835196843674e-05	4.34310182576657	3.05117591386949	48.6969925271007	3.71976276752962e-06	lineage4	dr_mutations_pyrazinamide	LEU	140603921,SAMN05276312	SRR3675218	lineage4.1.1.3	gb	UK	pnca_p.val7leu	A	E	VAL	VA7	pnca_complex.pdb
377	V7L	L4	PZA	V	V7	7	L	0	Pre-XDR	DM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	5.336	-0.589	-1.137	-0.847275	-2.289	-0.99	83	91	-0.66	7	7	0	0	strand	1.73333333333333	11.02	0.0009343107661348	10.9471518987342	10.9471289278841	10.9440461901209	21.4040928993518	-26	0	0	0	0	0	-2	0	-3	0	1	-4	-2	-2	2	-0.14918946301925	-0.293798449612403	-0.162899907713605	-0.390281329923274	-0.259162303664921	0.873684210526316	-0.543657331136738	Destabilising	Destabilising	Stabilising	Destabilising	Destabilising	effect	-0.779	-0.615	8:7	146/150	V:I:A	2.39307722351576	6.83262964849249e-05	0.600967660910521	3.98203993188257	3.56185012264106	40.4315613280321	1.03930114423982	4.53835196843674e-05	4.34310182576657	3.05117591386949	48.6969925271007	3.71976276752962e-06	lineage4	dr_mutations_pyrazinamide	LEU	ERR2514424	ERR2514424	lineage4.1.1.3	gb	UK	pnca_p.val7leu	A	E	VAL	VA7	pnca_complex.pdb
378	V7L	L4	PZA	V	V7	7	L	1	Pre-MDR	DM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	5.336	-0.589	-1.137	-0.847275	-2.289	-0.99	83	91	-0.66	7	7	0	0	strand	1.73333333333333	11.02	0.0009343107661348	10.9471518987342	10.9471289278841	10.9440461901209	21.4040928993518	-26	0	0	0	0	0	-2	0	-3	0	1	-4	-2	-2	2	-0.14918946301925	-0.293798449612403	-0.162899907713605	-0.390281329923274	-0.259162303664921	0.873684210526316	-0.543657331136738	Destabilising	Destabilising	Stabilising	Destabilising	Destabilising	effect	-0.779	-0.615	8:7	146/150	V:I:A	2.39307722351576	6.83262964849249e-05	0.600967660910521	3.98203993188257	3.56185012264106	40.4315613280321	1.03930114423982	4.53835196843674e-05	4.34310182576657	3.05117591386949	48.6969925271007	3.71976276752962e-06	lineage4	dr_mutations_pyrazinamide	LEU	SAMN03647145	SRR2099972	lineage4.1.1.3			pnca_p.val7leu	A	E	VAL	VA7	pnca_complex.pdb
379	V7L	L4	PZA	V	V7	7	L	0	Pre-XDR	DM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	5.336	-0.589	-1.137	-0.847275	-2.289	-0.99	83	91	-0.66	7	7	0	0	strand	1.73333333333333	11.02	0.0009343107661348	10.9471518987342	10.9471289278841	10.9440461901209	21.4040928993518	-26	0	0	0	0	0	-2	0	-3	0	1	-4	-2	-2	2	-0.14918946301925	-0.293798449612403	-0.162899907713605	-0.390281329923274	-0.259162303664921	0.873684210526316	-0.543657331136738	Destabilising	Destabilising	Stabilising	Destabilising	Destabilising	effect	-0.779	-0.615	8:7	146/150	V:I:A	2.39307722351576	6.83262964849249e-05	0.600967660910521	3.98203993188257	3.56185012264106	40.4315613280321	1.03930114423982	4.53835196843674e-05	4.34310182576657	3.05117591386949	48.6969925271007	3.71976276752962e-06	lineage4	dr_mutations_pyrazinamide	LEU	ERR2516816	ERR2516816	lineage4.1.1.3	gb	UK	pnca_p.val7leu	A	E	VAL	VA7	pnca_complex.pdb
380	V7L	L4	PZA	V	V7	7	L	1	Pre-XDR	DM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	5.336	-0.589	-1.137	-0.847275	-2.289	-0.99	83	91	-0.66	7	7	0	0	strand	1.73333333333333	11.02	0.0009343107661348	10.9471518987342	10.9471289278841	10.9440461901209	21.4040928993518	-26	0	0	0	0	0	-2	0	-3	0	1	-4	-2	-2	2	-0.14918946301925	-0.293798449612403	-0.162899907713605	-0.390281329923274	-0.259162303664921	0.873684210526316	-0.543657331136738	Destabilising	Destabilising	Stabilising	Destabilising	Destabilising	effect	-0.779	-0.615	8:7	146/150	V:I:A	2.39307722351576	6.83262964849249e-05	0.600967660910521	3.98203993188257	3.56185012264106	40.4315613280321	1.03930114423982	4.53835196843674e-05	4.34310182576657	3.05117591386949	48.6969925271007	3.71976276752962e-06	lineage4	dr_mutations_pyrazinamide	LEU	ERR2514982	ERR2514982	lineage4.1.1.3	gb	UK	pnca_p.val7leu	A	E	VAL	VA7	pnca_complex.pdb
381	V7L	L4	PZA	V	V7	7	L	0	Pre-XDR	DM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	5.336	-0.589	-1.137	-0.847275	-2.289	-0.99	83	91	-0.66	7	7	0	0	strand	1.73333333333333	11.02	0.0009343107661348	10.9471518987342	10.9471289278841	10.9440461901209	21.4040928993518	-26	0	0	0	0	0	-2	0	-3	0	1	-4	-2	-2	2	-0.14918946301925	-0.293798449612403	-0.162899907713605	-0.390281329923274	-0.259162303664921	0.873684210526316	-0.543657331136738	Destabilising	Destabilising	Stabilising	Destabilising	Destabilising	effect	-0.779	-0.615	8:7	146/150	V:I:A	2.39307722351576	6.83262964849249e-05	0.600967660910521	3.98203993188257	3.56185012264106	40.4315613280321	1.03930114423982	4.53835196843674e-05	4.34310182576657	3.05117591386949	48.6969925271007	3.71976276752962e-06	lineage4	dr_mutations_pyrazinamide	LEU	ERR2514947	ERR2514947	lineage4.1.1.3	gb	UK	pnca_p.val7leu	A	E	VAL	VA7	pnca_complex.pdb
382	V7L	L4	PZA	V	V7	7	L	1	Pre-XDR	DM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	5.336	-0.589	-1.137	-0.847275	-2.289	-0.99	83	91	-0.66	7	7	0	0	strand	1.73333333333333	11.02	0.0009343107661348	10.9471518987342	10.9471289278841	10.9440461901209	21.4040928993518	-26	0	0	0	0	0	-2	0	-3	0	1	-4	-2	-2	2	-0.14918946301925	-0.293798449612403	-0.162899907713605	-0.390281329923274	-0.259162303664921	0.873684210526316	-0.543657331136738	Destabilising	Destabilising	Stabilising	Destabilising	Destabilising	effect	-0.779	-0.615	8:7	146/150	V:I:A	2.39307722351576	6.83262964849249e-05	0.600967660910521	3.98203993188257	3.56185012264106	40.4315613280321	1.03930114423982	4.53835196843674e-05	4.34310182576657	3.05117591386949	48.6969925271007	3.71976276752962e-06	lineage4	dr_mutations_pyrazinamide	LEU	ERR2516831	ERR2516831	lineage4.1.1.3	gb	UK	pnca_p.val7leu	A	E	VAL	VA7	pnca_complex.pdb
383	V7L	L4	PZA	V	V7	7	L	1	Pre-MDR	DM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	5.336	-0.589	-1.137	-0.847275	-2.289	-0.99	83	91	-0.66	7	7	0	0	strand	1.73333333333333	11.02	0.0009343107661348	10.9471518987342	10.9471289278841	10.9440461901209	21.4040928993518	-26	0	0	0	0	0	-2	0	-3	0	1	-4	-2	-2	2	-0.14918946301925	-0.293798449612403	-0.162899907713605	-0.390281329923274	-0.259162303664921	0.873684210526316	-0.543657331136738	Destabilising	Destabilising	Stabilising	Destabilising	Destabilising	effect	-0.779	-0.615	8:7	146/150	V:I:A	2.39307722351576	6.83262964849249e-05	0.600967660910521	3.98203993188257	3.56185012264106	40.4315613280321	1.03930114423982	4.53835196843674e-05	4.34310182576657	3.05117591386949	48.6969925271007	3.71976276752962e-06	lineage4	dr_mutations_pyrazinamide	LEU	SAMN03647894,SRR2100721	SRR2100721	lineage4.1.1.3			pnca_p.val7leu	A	E	VAL	VA7	pnca_complex.pdb
384	V7L	L4	PZA	V	V7	7	L	1	Pre-MDR	DM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	5.336	-0.589	-1.137	-0.847275	-2.289	-0.99	83	91	-0.66	7	7	0	0	strand	1.73333333333333	11.02	0.0009343107661348	10.9471518987342	10.9471289278841	10.9440461901209	21.4040928993518	-26	0	0	0	0	0	-2	0	-3	0	1	-4	-2	-2	2	-0.14918946301925	-0.293798449612403	-0.162899907713605	-0.390281329923274	-0.259162303664921	0.873684210526316	-0.543657331136738	Destabilising	Destabilising	Stabilising	Destabilising	Destabilising	effect	-0.779	-0.615	8:7	146/150	V:I:A	2.39307722351576	6.83262964849249e-05	0.600967660910521	3.98203993188257	3.56185012264106	40.4315613280321	1.03930114423982	4.53835196843674e-05	4.34310182576657	3.05117591386949	48.6969925271007	3.71976276752962e-06	lineage4	dr_mutations_pyrazinamide	LEU	SRR2101039,SAMN03648286	SRR2101039	lineage4.1.1.3			pnca_p.val7leu	A	E	VAL	VA7	pnca_complex.pdb
385	V7L	L4	PZA	V	V7	7	L	1	Pre-MDR	DM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	5.336	-0.589	-1.137	-0.847275	-2.289	-0.99	83	91	-0.66	7	7	0	0	strand	1.73333333333333	11.02	0.0009343107661348	10.9471518987342	10.9471289278841	10.9440461901209	21.4040928993518	-26	0	0	0	0	0	-2	0	-3	0	1	-4	-2	-2	2	-0.14918946301925	-0.293798449612403	-0.162899907713605	-0.390281329923274	-0.259162303664921	0.873684210526316	-0.543657331136738	Destabilising	Destabilising	Stabilising	Destabilising	Destabilising	effect	-0.779	-0.615	8:7	146/150	V:I:A	2.39307722351576	6.83262964849249e-05	0.600967660910521	3.98203993188257	3.56185012264106	40.4315613280321	1.03930114423982	4.53835196843674e-05	4.34310182576657	3.05117591386949	48.6969925271007	3.71976276752962e-06	lineage4	dr_mutations_pyrazinamide	LEU	SRR2469373,SAMN04099730	SRR2469373	lineage4.1.1.3			pnca_p.val7leu	A	E	VAL	VA7	pnca_complex.pdb
386	V7L	L4	PZA	V	V7	7	L	NA	Pre-MDR	DM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	5.336	-0.589	-1.137	-0.847275	-2.289	-0.99	83	91	-0.66	7	7	0	0	strand	1.73333333333333	11.02	0.0009343107661348	10.9471518987342	10.9471289278841	10.9440461901209	21.4040928993518	-26	0	0	0	0	0	-2	0	-3	0	1	-4	-2	-2	2	-0.14918946301925	-0.293798449612403	-0.162899907713605	-0.390281329923274	-0.259162303664921	0.873684210526316	-0.543657331136738	Destabilising	Destabilising	Stabilising	Destabilising	Destabilising	effect	-0.779	-0.615	8:7	146/150	V:I:A	2.39307722351576	6.83262964849249e-05	0.600967660910521	3.98203993188257	3.56185012264106	40.4315613280321	1.03930114423982	4.53835196843674e-05	4.34310182576657	3.05117591386949	48.6969925271007	3.71976276752962e-06	lineage4	dr_mutations_pyrazinamide	LEU	SAMN04365146	SRR3055242	lineage4.1.1.3			pnca_p.val7leu	A	E	VAL	VA7	pnca_complex.pdb
387	V7L	L4	PZA	V	V7	7	L	1	Pre-MDR	DM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	5.336	-0.589	-1.137	-0.847275	-2.289	-0.99	83	91	-0.66	7	7	0	0	strand	1.73333333333333	11.02	0.0009343107661348	10.9471518987342	10.9471289278841	10.9440461901209	21.4040928993518	-26	0	0	0	0	0	-2	0	-3	0	1	-4	-2	-2	2	-0.14918946301925	-0.293798449612403	-0.162899907713605	-0.390281329923274	-0.259162303664921	0.873684210526316	-0.543657331136738	Destabilising	Destabilising	Stabilising	Destabilising	Destabilising	effect	-0.779	-0.615	8:7	146/150	V:I:A	2.39307722351576	6.83262964849249e-05	0.600967660910521	3.98203993188257	3.56185012264106	40.4315613280321	1.03930114423982	4.53835196843674e-05	4.34310182576657	3.05117591386949	48.6969925271007	3.71976276752962e-06	lineage4	dr_mutations_pyrazinamide	LEU	ERR2514008	ERR2514008	lineage4.1.1.3	gb	UK	pnca_p.val7leu	A	E	VAL	VA7	pnca_complex.pdb
388	V7L	L4	PZA	V	V7	7	L	NA	Pre-XDR	DM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	5.336	-0.589	-1.137	-0.847275	-2.289	-0.99	83	91	-0.66	7	7	0	0	strand	1.73333333333333	11.02	0.0009343107661348	10.9471518987342	10.9471289278841	10.9440461901209	21.4040928993518	-26	0	0	0	0	0	-2	0	-3	0	1	-4	-2	-2	2	-0.14918946301925	-0.293798449612403	-0.162899907713605	-0.390281329923274	-0.259162303664921	0.873684210526316	-0.543657331136738	Destabilising	Destabilising	Stabilising	Destabilising	Destabilising	effect	-0.779	-0.615	8:7	146/150	V:I:A	2.39307722351576	6.83262964849249e-05	0.600967660910521	3.98203993188257	3.56185012264106	40.4315613280321	1.03930114423982	4.53835196843674e-05	4.34310182576657	3.05117591386949	48.6969925271007	3.71976276752962e-06	lineage4	dr_mutations_pyrazinamide	LEU	ERR2513631	ERR2513631	lineage4.1.1.3	gb	UK	pnca_p.val7leu	A	E	VAL	VA7	pnca_complex.pdb
389	V7L	L4	PZA	V	V7	7	L	0	XDR	DM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	5.336	-0.589	-1.137	-0.847275	-2.289	-0.99	83	91	-0.66	7	7	0	0	strand	1.73333333333333	11.02	0.0009343107661348	10.9471518987342	10.9471289278841	10.9440461901209	21.4040928993518	-26	0	0	0	0	0	-2	0	-3	0	1	-4	-2	-2	2	-0.14918946301925	-0.293798449612403	-0.162899907713605	-0.390281329923274	-0.259162303664921	0.873684210526316	-0.543657331136738	Destabilising	Destabilising	Stabilising	Destabilising	Destabilising	effect	-0.779	-0.615	8:7	146/150	V:I:A	2.39307722351576	6.83262964849249e-05	0.600967660910521	3.98203993188257	3.56185012264106	40.4315613280321	1.03930114423982	4.53835196843674e-05	4.34310182576657	3.05117591386949	48.6969925271007	3.71976276752962e-06	lineage4	dr_mutations_pyrazinamide	LEU	ERR2513957	ERR2513957	lineage4.1.1.3	gb	UK	pnca_p.val7leu	A	E	VAL	VA7	pnca_complex.pdb
390	V7L	L4	PZA	V	V7	7	L	1	Pre-XDR	DM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	5.336	-0.589	-1.137	-0.847275	-2.289	-0.99	83	91	-0.66	7	7	0	0	strand	1.73333333333333	11.02	0.0009343107661348	10.9471518987342	10.9471289278841	10.9440461901209	21.4040928993518	-26	0	0	0	0	0	-2	0	-3	0	1	-4	-2	-2	2	-0.14918946301925	-0.293798449612403	-0.162899907713605	-0.390281329923274	-0.259162303664921	0.873684210526316	-0.543657331136738	Destabilising	Destabilising	Stabilising	Destabilising	Destabilising	effect	-0.779	-0.615	8:7	146/150	V:I:A	2.39307722351576	6.83262964849249e-05	0.600967660910521	3.98203993188257	3.56185012264106	40.4315613280321	1.03930114423982	4.53835196843674e-05	4.34310182576657	3.05117591386949	48.6969925271007	3.71976276752962e-06	lineage4	dr_mutations_pyrazinamide	LEU	614509	SRR5007178	lineage4.1.1.3	gb	United Kingdom	pnca_p.val7leu	A	E	VAL	VA7	pnca_complex.pdb
391	V7L	L4	PZA	V	V7	7	L	NA	Pre-XDR	DM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	5.336	-0.589	-1.137	-0.847275	-2.289	-0.99	83	91	-0.66	7	7	0	0	strand	1.73333333333333	11.02	0.0009343107661348	10.9471518987342	10.9471289278841	10.9440461901209	21.4040928993518	-26	0	0	0	0	0	-2	0	-3	0	1	-4	-2	-2	2	-0.14918946301925	-0.293798449612403	-0.162899907713605	-0.390281329923274	-0.259162303664921	0.873684210526316	-0.543657331136738	Destabilising	Destabilising	Stabilising	Destabilising	Destabilising	effect	-0.779	-0.615	8:7	146/150	V:I:A	2.39307722351576	6.83262964849249e-05	0.600967660910521	3.98203993188257	3.56185012264106	40.4315613280321	1.03930114423982	4.53835196843674e-05	4.34310182576657	3.05117591386949	48.6969925271007	3.71976276752962e-06	lineage4	dr_mutations_pyrazinamide	LEU	SAMN07660385	SRR6046819	lineage4.1.1.3	gb	UK	pnca_p.val7leu	A	E	VAL	VA7	pnca_complex.pdb
392	D8A	L2	PZA	D	D8	8	A	NA	Pre-XDR	DM	hydrophilic	hydrophobic	acidic	non-polar	neg	non-polar	3.22	-3.268	-0.511	0.541028	-1.125	0.4	87	91	-1.187	9	9	5	0.0259067357512953	loop	1.63333333333333	9.48	0.0001437401178668	19.411022297013	511754.463552623	Inf	4.73122070382274	26	36	0	36	0	0	0	4	-5	0	-4	-1	0	6	1	-0.827760891590679	-0.132041343669251	0.0197054174345676	-0.191815856777494	0.224719101123595	0.91578947368421	-0.977759472817133	Destabilising	Destabilising	Destabilising	Destabilising	Stabilising	effect	-1.221	-1.178	9:9	146/150	D:H	13.1456002256206	0.924803768447001	139.277183326572	0.094384449136922	0.0001628371344451	NA	1.28804840845689	0.0292235860951597	1.53426649183163	0.91081598550184	Inf	0.0296198560706035	lineage2	dr_mutations_pyrazinamide	ALA	SRR5709862,SAMN07236319	SRR5709862	lineage2.2.1	th	Thailand	pnca_p.asp8ala	A	-	ASP	DA8	pnca_complex.pdb
393	D8A	L2	PZA	D	D8	8	A	NA	Pre-MDR	DM	hydrophilic	hydrophobic	acidic	non-polar	neg	non-polar	3.22	-3.268	-0.511	0.541028	-1.125	0.4	87	91	-1.187	9	9	5	0.0259067357512953	loop	1.63333333333333	9.48	0.0001437401178668	19.411022297013	511754.463552623	Inf	4.73122070382274	26	36	0	36	0	0	0	4	-5	0	-4	-1	0	6	1	-0.827760891590679	-0.132041343669251	0.0197054174345676	-0.191815856777494	0.224719101123595	0.91578947368421	-0.977759472817133	Destabilising	Destabilising	Destabilising	Destabilising	Stabilising	effect	-1.221	-1.178	9:9	146/150	D:H	13.1456002256206	0.924803768447001	139.277183326572	0.094384449136922	0.0001628371344451	NA	1.28804840845689	0.0292235860951597	1.53426649183163	0.91081598550184	Inf	0.0296198560706035	lineage2	dr_mutations_pyrazinamide	ALA	SRS797286	SRR1723814_SRR1723813_SRR1723815	lineage2.2.1	cn	China:Anhui	pnca_p.asp8ala	A	-	ASP	DA8	pnca_complex.pdb
394	D8A	L2	PZA	D	D8	8	A	1	MDR	DM	hydrophilic	hydrophobic	acidic	non-polar	neg	non-polar	3.22	-3.268	-0.511	0.541028	-1.125	0.4	87	91	-1.187	9	9	5	0.0259067357512953	loop	1.63333333333333	9.48	0.0001437401178668	19.411022297013	511754.463552623	Inf	4.73122070382274	26	36	0	36	0	0	0	4	-5	0	-4	-1	0	6	1	-0.827760891590679	-0.132041343669251	0.0197054174345676	-0.191815856777494	0.224719101123595	0.91578947368421	-0.977759472817133	Destabilising	Destabilising	Destabilising	Destabilising	Stabilising	effect	-1.221	-1.178	9:9	146/150	D:H	13.1456002256206	0.924803768447001	139.277183326572	0.094384449136922	0.0001628371344451	NA	1.28804840845689	0.0292235860951597	1.53426649183163	0.91081598550184	Inf	0.0296198560706035	lineage2	dr_mutations_pyrazinamide	ALA	ERR553107	ERR553107	lineage2.2.1	in	India	pnca_p.asp8ala	A	-	ASP	DA8	pnca_complex.pdb
395	D8A	L2	PZA	D	D8	8	A	NA	Pre-XDR	DM	hydrophilic	hydrophobic	acidic	non-polar	neg	non-polar	3.22	-3.268	-0.511	0.541028	-1.125	0.4	87	91	-1.187	9	9	5	0.0259067357512953	loop	1.63333333333333	9.48	0.0001437401178668	19.411022297013	511754.463552623	Inf	4.73122070382274	26	36	0	36	0	0	0	4	-5	0	-4	-1	0	6	1	-0.827760891590679	-0.132041343669251	0.0197054174345676	-0.191815856777494	0.224719101123595	0.91578947368421	-0.977759472817133	Destabilising	Destabilising	Destabilising	Destabilising	Stabilising	effect	-1.221	-1.178	9:9	146/150	D:H	13.1456002256206	0.924803768447001	139.277183326572	0.094384449136922	0.0001628371344451	NA	1.28804840845689	0.0292235860951597	1.53426649183163	0.91081598550184	Inf	0.0296198560706035	lineage2	dr_mutations_pyrazinamide	ALA	SAMN07236317,SRR5709816	SRR5709816	lineage2.2.1	th	Thailand	pnca_p.asp8ala	A	-	ASP	DA8	pnca_complex.pdb
396	D8A	L4	PZA	D	D8	8	A	NA	MDR	DM	hydrophilic	hydrophobic	acidic	non-polar	neg	non-polar	3.22	-3.268	-0.511	0.541028	-1.125	0.4	87	91	-1.187	9	9	5	0.0259067357512953	loop	1.63333333333333	9.48	0.0001437401178668	19.411022297013	511754.463552623	Inf	4.73122070382274	26	36	0	36	0	0	0	4	-5	0	-4	-1	0	6	1	-0.827760891590679	-0.132041343669251	0.0197054174345676	-0.191815856777494	0.224719101123595	0.91578947368421	-0.977759472817133	Destabilising	Destabilising	Destabilising	Destabilising	Stabilising	effect	-1.221	-1.178	9:9	146/150	D:H	13.1456002256206	0.924803768447001	139.277183326572	0.094384449136922	0.0001628371344451	NA	1.28804840845689	0.0292235860951597	1.53426649183163	0.91081598550184	Inf	0.0296198560706035	lineage4	dr_mutations_pyrazinamide	ALA	ERR751520	ERR751520	lineage4.1.1	pe		pnca_p.asp8ala	A	-	ASP	DA8	pnca_complex.pdb
397	D8A	L2	PZA	D	D8	8	A	1	Pre-MDR	DM	hydrophilic	hydrophobic	acidic	non-polar	neg	non-polar	3.22	-3.268	-0.511	0.541028	-1.125	0.4	87	91	-1.187	9	9	5	0.0259067357512953	loop	1.63333333333333	9.48	0.0001437401178668	19.411022297013	511754.463552623	Inf	4.73122070382274	26	36	0	36	0	0	0	4	-5	0	-4	-1	0	6	1	-0.827760891590679	-0.132041343669251	0.0197054174345676	-0.191815856777494	0.224719101123595	0.91578947368421	-0.977759472817133	Destabilising	Destabilising	Destabilising	Destabilising	Stabilising	effect	-1.221	-1.178	9:9	146/150	D:H	13.1456002256206	0.924803768447001	139.277183326572	0.094384449136922	0.0001628371344451	NA	1.28804840845689	0.0292235860951597	1.53426649183163	0.91081598550184	Inf	0.0296198560706035	lineage2	dr_mutations_pyrazinamide	ALA	MDR_12448	SRR6824632	lineage2.2.1	cn	China: Shou County, Lu'an City, Anhui Province	pnca_p.asp8ala	A	-	ASP	DA8	pnca_complex.pdb
398	D8E	L4	PZA	D	D8	8	E	NA	Pre-XDR	DM	hydrophilic	hydrophilic	acidic	acidic	neg	neg	3.22	0.012	-0.786	1.90122	-1.417	-0.4	90	95	-1.187	9	9	5	0.0259067357512953	loop	1.63333333333333	9.48	0.0002874802357337	14.5631313131313	14.5630810302278	14.5631012253236	5.81873994206135	-24	-28	0	-28	-2	0	-2	0	2	0	2	-1	-8	-10	-6	0.0053811659192825	-0.203100775193798	0.0692465708520604	-0.241602728047741	-0.104712041884817	0.947368421052632	-0.977759472817133	Stabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.221	-1.178	9:9	146/150	D:H	2.67848962960141	0.0202679102821361	1.15384949648317	2.3213509541454	1.86363317860697	294.488177945815	1.16325476548539	0.0174140488202037	1.75910024233227	1.16837785201846	760.989759542733	0.0158563003544608	lineage4	dr_mutations_pyrazinamide	GLU	ERR2510171	ERR2510171	lineage4	pe	Peru	pnca_p.asp8glu	A	-	ASP	DA8	pnca_complex.pdb
399	D8E	L2	PZA	D	D8	8	E	1	MDR	DM	hydrophilic	hydrophilic	acidic	acidic	neg	neg	3.22	0.012	-0.786	1.90122	-1.417	-0.4	90	95	-1.187	9	9	5	0.0259067357512953	loop	1.63333333333333	9.48	0.0002874802357337	14.5631313131313	14.5630810302278	14.5631012253236	5.81873994206135	-24	-28	0	-28	-2	0	-2	0	2	0	2	-1	-8	-10	-6	0.0053811659192825	-0.203100775193798	0.0692465708520604	-0.241602728047741	-0.104712041884817	0.947368421052632	-0.977759472817133	Stabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.221	-1.178	9:9	146/150	D:H	2.67848962960141	0.0202679102821361	1.15384949648317	2.3213509541454	1.86363317860697	294.488177945815	1.16325476548539	0.0174140488202037	1.75910024233227	1.16837785201846	760.989759542733	0.0158563003544608	lineage2	dr_mutations_pyrazinamide	GLU	ERR108421,1052V-sc-2011-10-12T14:58:09Z-1289086	ERR108421	lineage2.2.1	ru	Russia,Samara	pnca_p.asp8glu	A	-	ASP	DA8	pnca_complex.pdb
400	D8E	L2	PZA	D	D8	8	E	NA	MDR	DM	hydrophilic	hydrophilic	acidic	acidic	neg	neg	3.22	0.012	-0.786	1.90122	-1.417	-0.4	90	95	-1.187	9	9	5	0.0259067357512953	loop	1.63333333333333	9.48	0.0002874802357337	14.5631313131313	14.5630810302278	14.5631012253236	5.81873994206135	-24	-28	0	-28	-2	0	-2	0	2	0	2	-1	-8	-10	-6	0.0053811659192825	-0.203100775193798	0.0692465708520604	-0.241602728047741	-0.104712041884817	0.947368421052632	-0.977759472817133	Stabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.221	-1.178	9:9	146/150	D:H	2.67848962960141	0.0202679102821361	1.15384949648317	2.3213509541454	1.86363317860697	294.488177945815	1.16325476548539	0.0174140488202037	1.75910024233227	1.16837785201846	760.989759542733	0.0158563003544608	lineage2	dr_mutations_pyrazinamide	GLU	ERR108477	ERR108477	lineage2.2.1	ru	Russia	pnca_p.asp8glu	A	-	ASP	DA8	pnca_complex.pdb
401	D8E	L4	PZA	D	D8	8	E	NA	Pre-XDR	DM	hydrophilic	hydrophilic	acidic	acidic	neg	neg	3.22	0.012	-0.786	1.90122	-1.417	-0.4	90	95	-1.187	9	9	5	0.0259067357512953	loop	1.63333333333333	9.48	0.0002874802357337	14.5631313131313	14.5630810302278	14.5631012253236	5.81873994206135	-24	-28	0	-28	-2	0	-2	0	2	0	2	-1	-8	-10	-6	0.0053811659192825	-0.203100775193798	0.0692465708520604	-0.241602728047741	-0.104712041884817	0.947368421052632	-0.977759472817133	Stabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.221	-1.178	9:9	146/150	D:H	2.67848962960141	0.0202679102821361	1.15384949648317	2.3213509541454	1.86363317860697	294.488177945815	1.16325476548539	0.0174140488202037	1.75910024233227	1.16837785201846	760.989759542733	0.0158563003544608	lineage4	dr_mutations_pyrazinamide	GLU	ERR775389	ERR775389	lineage4	pe		pnca_p.asp8glu	A	-	ASP	DA8	pnca_complex.pdb
402	D8E	L4	PZA	D	D8	8	E	NA	Pre-XDR	DM	hydrophilic	hydrophilic	acidic	acidic	neg	neg	3.22	0.012	-0.786	1.90122	-1.417	-0.4	90	95	-1.187	9	9	5	0.0259067357512953	loop	1.63333333333333	9.48	0.0002874802357337	14.5631313131313	14.5630810302278	14.5631012253236	5.81873994206135	-24	-28	0	-28	-2	0	-2	0	2	0	2	-1	-8	-10	-6	0.0053811659192825	-0.203100775193798	0.0692465708520604	-0.241602728047741	-0.104712041884817	0.947368421052632	-0.977759472817133	Stabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.221	-1.178	9:9	146/150	D:H	2.67848962960141	0.0202679102821361	1.15384949648317	2.3213509541454	1.86363317860697	294.488177945815	1.16325476548539	0.0174140488202037	1.75910024233227	1.16837785201846	760.989759542733	0.0158563003544608	lineage4	dr_mutations_pyrazinamide	GLU	ERR1034831	ERR1034831	lineage4.3.4.1	pt	Portugal	pnca_p.asp8glu	A	-	ASP	DA8	pnca_complex.pdb
403	D8E	L2	PZA	D	D8	8	E	1	MDR	DM	hydrophilic	hydrophilic	acidic	acidic	neg	neg	3.22	0.012	-0.786	1.90122	-1.417	-0.4	90	95	-1.187	9	9	5	0.0259067357512953	loop	1.63333333333333	9.48	0.0002874802357337	14.5631313131313	14.5630810302278	14.5631012253236	5.81873994206135	-24	-28	0	-28	-2	0	-2	0	2	0	2	-1	-8	-10	-6	0.0053811659192825	-0.203100775193798	0.0692465708520604	-0.241602728047741	-0.104712041884817	0.947368421052632	-0.977759472817133	Stabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.221	-1.178	9:9	146/150	D:H	2.67848962960141	0.0202679102821361	1.15384949648317	2.3213509541454	1.86363317860697	294.488177945815	1.16325476548539	0.0174140488202037	1.75910024233227	1.16837785201846	760.989759542733	0.0158563003544608	lineage2	dr_mutations_pyrazinamide	GLU	ERR2510862	ERR2510862	lineage2.2.1	it	Italy	pnca_p.asp8glu	A	-	ASP	DA8	pnca_complex.pdb
404	D8E	L2	PZA	D	D8	8	E	0	MDR	DM	hydrophilic	hydrophilic	acidic	acidic	neg	neg	3.22	0.012	-0.786	1.90122	-1.417	-0.4	90	95	-1.187	9	9	5	0.0259067357512953	loop	1.63333333333333	9.48	0.0002874802357337	14.5631313131313	14.5630810302278	14.5631012253236	5.81873994206135	-24	-28	0	-28	-2	0	-2	0	2	0	2	-1	-8	-10	-6	0.0053811659192825	-0.203100775193798	0.0692465708520604	-0.241602728047741	-0.104712041884817	0.947368421052632	-0.977759472817133	Stabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.221	-1.178	9:9	146/150	D:H	2.67848962960141	0.0202679102821361	1.15384949648317	2.3213509541454	1.86363317860697	294.488177945815	1.16325476548539	0.0174140488202037	1.75910024233227	1.16837785201846	760.989759542733	0.0158563003544608	lineage2	dr_mutations_pyrazinamide	GLU	ERR553238,SAMEA2535237	ERR553238	lineage2.2.1			pnca_p.asp8glu	A	-	ASP	DA8	pnca_complex.pdb
405	D8E	L4	PZA	D	D8	8	E	NA	MDR	DM	hydrophilic	hydrophilic	acidic	acidic	neg	neg	3.22	0.012	-0.786	1.90122	-1.417	-0.4	90	95	-1.187	9	9	5	0.0259067357512953	loop	1.63333333333333	9.48	0.0002874802357337	14.5631313131313	14.5630810302278	14.5631012253236	5.81873994206135	-24	-28	0	-28	-2	0	-2	0	2	0	2	-1	-8	-10	-6	0.0053811659192825	-0.203100775193798	0.0692465708520604	-0.241602728047741	-0.104712041884817	0.947368421052632	-0.977759472817133	Stabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.221	-1.178	9:9	146/150	D:H	2.67848962960141	0.0202679102821361	1.15384949648317	2.3213509541454	1.86363317860697	294.488177945815	1.16325476548539	0.0174140488202037	1.75910024233227	1.16837785201846	760.989759542733	0.0158563003544608	lineage4	dr_mutations_pyrazinamide	GLU	ERR2707214	ERR2707214	lineage4.1.1	cd	Democratic Republic of Congo	pnca_p.asp8glu	A	-	ASP	DA8	pnca_complex.pdb
406	D8E	L4	PZA	D	D8	8	E	NA	Pre-XDR	DM	hydrophilic	hydrophilic	acidic	acidic	neg	neg	3.22	0.012	-0.786	1.90122	-1.417	-0.4	90	95	-1.187	9	9	5	0.0259067357512953	loop	1.63333333333333	9.48	0.0002874802357337	14.5631313131313	14.5630810302278	14.5631012253236	5.81873994206135	-24	-28	0	-28	-2	0	-2	0	2	0	2	-1	-8	-10	-6	0.0053811659192825	-0.203100775193798	0.0692465708520604	-0.241602728047741	-0.104712041884817	0.947368421052632	-0.977759472817133	Stabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.221	-1.178	9:9	146/150	D:H	2.67848962960141	0.0202679102821361	1.15384949648317	2.3213509541454	1.86363317860697	294.488177945815	1.16325476548539	0.0174140488202037	1.75910024233227	1.16837785201846	760.989759542733	0.0158563003544608	lineage4	dr_mutations_pyrazinamide	GLU	ERR845936	ERR845936	lineage4	pe		pnca_p.asp8glu	A	-	ASP	DA8	pnca_complex.pdb
407	D8E	L2	PZA	D	D8	8	E	1	Pre-XDR	DM	hydrophilic	hydrophilic	acidic	acidic	neg	neg	3.22	0.012	-0.786	1.90122	-1.417	-0.4	90	95	-1.187	9	9	5	0.0259067357512953	loop	1.63333333333333	9.48	0.0002874802357337	14.5631313131313	14.5630810302278	14.5631012253236	5.81873994206135	-24	-28	0	-28	-2	0	-2	0	2	0	2	-1	-8	-10	-6	0.0053811659192825	-0.203100775193798	0.0692465708520604	-0.241602728047741	-0.104712041884817	0.947368421052632	-0.977759472817133	Stabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.221	-1.178	9:9	146/150	D:H	2.67848962960141	0.0202679102821361	1.15384949648317	2.3213509541454	1.86363317860697	294.488177945815	1.16325476548539	0.0174140488202037	1.75910024233227	1.16837785201846	760.989759542733	0.0158563003544608	lineage2	dr_mutations_pyrazinamide	GLU	ERR117454,0710Y-sc-2011-10-12T14:59:44Z-1289188	ERR117454	lineage2.2.1	ru	Russia,Samara	pnca_p.asp8glu	A	-	ASP	DA8	pnca_complex.pdb
408	D8G	L2;L4	PZA	D	D8	8	G	NA	MDR	DM	hydrophilic	hydrophobic	acidic	neutral	neg	non-polar	3.22	-3.445	-0.851	1.89305	-1.078	-0.82	92	95	-1.187	9	9	5	0.0259067357512953	loop	1.63333333333333	9.48	0.0007905706482679	48.6872097931617	48.6872048041474	48.6746878162623	37.2619168572472	34	38	0	38	0	0	0	0	-8	-1	-3	-5	6	9	17	-0.872593718338399	-0.219896640826873	0.0689490016681357	-0.183802216538789	-0.214659685863874	0.968421052631579	-0.977759472817133	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.221	-1.178	9:9	146/150	D:H	3.88541626053988	0.0002118075877291	1.0488367141091	3.70450062271154	9.3197738725557	893.78337229237	1.68741488635211	1.95392414212297e-07	6.70909230105579	6.91781679568266	2088.84994220519	1.03281930722422e-09	lineage2;lineage4	dr_mutations_pyrazinamide	GLY	SRR5818641	SRR5818641	lineage4;lineage2.2.1	dj	Djibouti	pnca_p.asp8gly	A	-	ASP	DA8	pnca_complex.pdb
409	D8G	L2	PZA	D	D8	8	G	1	Pre-XDR	DM	hydrophilic	hydrophobic	acidic	neutral	neg	non-polar	3.22	-3.445	-0.851	1.89305	-1.078	-0.82	92	95	-1.187	9	9	5	0.0259067357512953	loop	1.63333333333333	9.48	0.0007905706482679	48.6872097931617	48.6872048041474	48.6746878162623	37.2619168572472	34	38	0	38	0	0	0	0	-8	-1	-3	-5	6	9	17	-0.872593718338399	-0.219896640826873	0.0689490016681357	-0.183802216538789	-0.214659685863874	0.968421052631579	-0.977759472817133	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.221	-1.178	9:9	146/150	D:H	3.88541626053988	0.0002118075877291	1.0488367141091	3.70450062271154	9.3197738725557	893.78337229237	1.68741488635211	1.95392414212297e-07	6.70909230105579	6.91781679568266	2088.84994220519	1.03281930722422e-09	lineage2	dr_mutations_pyrazinamide	GLY	ERS2592737	ERR2677386	lineage2.2.1	de	Germany	pnca_p.asp8gly	A	-	ASP	DA8	pnca_complex.pdb
410	D8G	L2	PZA	D	D8	8	G	1	MDR	DM	hydrophilic	hydrophobic	acidic	neutral	neg	non-polar	3.22	-3.445	-0.851	1.89305	-1.078	-0.82	92	95	-1.187	9	9	5	0.0259067357512953	loop	1.63333333333333	9.48	0.0007905706482679	48.6872097931617	48.6872048041474	48.6746878162623	37.2619168572472	34	38	0	38	0	0	0	0	-8	-1	-3	-5	6	9	17	-0.872593718338399	-0.219896640826873	0.0689490016681357	-0.183802216538789	-0.214659685863874	0.968421052631579	-0.977759472817133	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.221	-1.178	9:9	146/150	D:H	3.88541626053988	0.0002118075877291	1.0488367141091	3.70450062271154	9.3197738725557	893.78337229237	1.68741488635211	1.95392414212297e-07	6.70909230105579	6.91781679568266	2088.84994220519	1.03281930722422e-09	lineage2	dr_mutations_pyrazinamide	GLY	ERR2517005	ERR2517005	lineage2.2.1	gb	UK	pnca_p.asp8gly	A	-	ASP	DA8	pnca_complex.pdb
411	D8G	L4	PZA	D	D8	8	G	NA	Pre-MDR	DM	hydrophilic	hydrophobic	acidic	neutral	neg	non-polar	3.22	-3.445	-0.851	1.89305	-1.078	-0.82	92	95	-1.187	9	9	5	0.0259067357512953	loop	1.63333333333333	9.48	0.0007905706482679	48.6872097931617	48.6872048041474	48.6746878162623	37.2619168572472	34	38	0	38	0	0	0	0	-8	-1	-3	-5	6	9	17	-0.872593718338399	-0.219896640826873	0.0689490016681357	-0.183802216538789	-0.214659685863874	0.968421052631579	-0.977759472817133	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.221	-1.178	9:9	146/150	D:H	3.88541626053988	0.0002118075877291	1.0488367141091	3.70450062271154	9.3197738725557	893.78337229237	1.68741488635211	1.95392414212297e-07	6.70909230105579	6.91781679568266	2088.84994220519	1.03281930722422e-09	lineage4	dr_mutations_pyrazinamide	GLY	ERR1213926	ERR1213926	lineage4.1.2.1	ma	Morocco	pnca_p.asp8gly	A	-	ASP	DA8	pnca_complex.pdb
412	D8G	L2	PZA	D	D8	8	G	1	Pre-XDR	DM	hydrophilic	hydrophobic	acidic	neutral	neg	non-polar	3.22	-3.445	-0.851	1.89305	-1.078	-0.82	92	95	-1.187	9	9	5	0.0259067357512953	loop	1.63333333333333	9.48	0.0007905706482679	48.6872097931617	48.6872048041474	48.6746878162623	37.2619168572472	34	38	0	38	0	0	0	0	-8	-1	-3	-5	6	9	17	-0.872593718338399	-0.219896640826873	0.0689490016681357	-0.183802216538789	-0.214659685863874	0.968421052631579	-0.977759472817133	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.221	-1.178	9:9	146/150	D:H	3.88541626053988	0.0002118075877291	1.0488367141091	3.70450062271154	9.3197738725557	893.78337229237	1.68741488635211	1.95392414212297e-07	6.70909230105579	6.91781679568266	2088.84994220519	1.03281930722422e-09	lineage2	dr_mutations_pyrazinamide	GLY	ERS2592787	ERR2677441	lineage2.2.1	de	Germany	pnca_p.asp8gly	A	-	ASP	DA8	pnca_complex.pdb
413	D8G	L2	PZA	D	D8	8	G	1	MDR	DM	hydrophilic	hydrophobic	acidic	neutral	neg	non-polar	3.22	-3.445	-0.851	1.89305	-1.078	-0.82	92	95	-1.187	9	9	5	0.0259067357512953	loop	1.63333333333333	9.48	0.0007905706482679	48.6872097931617	48.6872048041474	48.6746878162623	37.2619168572472	34	38	0	38	0	0	0	0	-8	-1	-3	-5	6	9	17	-0.872593718338399	-0.219896640826873	0.0689490016681357	-0.183802216538789	-0.214659685863874	0.968421052631579	-0.977759472817133	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.221	-1.178	9:9	146/150	D:H	3.88541626053988	0.0002118075877291	1.0488367141091	3.70450062271154	9.3197738725557	893.78337229237	1.68741488635211	1.95392414212297e-07	6.70909230105579	6.91781679568266	2088.84994220519	1.03281930722422e-09	lineage2	dr_mutations_pyrazinamide	GLY	SAMN03648082,SRR2100909	SRR2100909	lineage2.2.1			pnca_p.asp8gly	A	-	ASP	DA8	pnca_complex.pdb
414	D8G	L2	PZA	D	D8	8	G	1	Pre-XDR	DM	hydrophilic	hydrophobic	acidic	neutral	neg	non-polar	3.22	-3.445	-0.851	1.89305	-1.078	-0.82	92	95	-1.187	9	9	5	0.0259067357512953	loop	1.63333333333333	9.48	0.0007905706482679	48.6872097931617	48.6872048041474	48.6746878162623	37.2619168572472	34	38	0	38	0	0	0	0	-8	-1	-3	-5	6	9	17	-0.872593718338399	-0.219896640826873	0.0689490016681357	-0.183802216538789	-0.214659685863874	0.968421052631579	-0.977759472817133	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.221	-1.178	9:9	146/150	D:H	3.88541626053988	0.0002118075877291	1.0488367141091	3.70450062271154	9.3197738725557	893.78337229237	1.68741488635211	1.95392414212297e-07	6.70909230105579	6.91781679568266	2088.84994220519	1.03281930722422e-09	lineage2	dr_mutations_pyrazinamide	GLY	ERS2592739	ERR2677389	lineage2.2.1	de	Germany	pnca_p.asp8gly	A	-	ASP	DA8	pnca_complex.pdb
415	D8G	L2	PZA	D	D8	8	G	1	MDR	DM	hydrophilic	hydrophobic	acidic	neutral	neg	non-polar	3.22	-3.445	-0.851	1.89305	-1.078	-0.82	92	95	-1.187	9	9	5	0.0259067357512953	loop	1.63333333333333	9.48	0.0007905706482679	48.6872097931617	48.6872048041474	48.6746878162623	37.2619168572472	34	38	0	38	0	0	0	0	-8	-1	-3	-5	6	9	17	-0.872593718338399	-0.219896640826873	0.0689490016681357	-0.183802216538789	-0.214659685863874	0.968421052631579	-0.977759472817133	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.221	-1.178	9:9	146/150	D:H	3.88541626053988	0.0002118075877291	1.0488367141091	3.70450062271154	9.3197738725557	893.78337229237	1.68741488635211	1.95392414212297e-07	6.70909230105579	6.91781679568266	2088.84994220519	1.03281930722422e-09	lineage2	dr_mutations_pyrazinamide	GLY	ERR2516875	ERR2516875	lineage2.2.1	gb	UK	pnca_p.asp8gly	A	-	ASP	DA8	pnca_complex.pdb
416	D8G	L4	PZA	D	D8	8	G	NA	MDR	DM	hydrophilic	hydrophobic	acidic	neutral	neg	non-polar	3.22	-3.445	-0.851	1.89305	-1.078	-0.82	92	95	-1.187	9	9	5	0.0259067357512953	loop	1.63333333333333	9.48	0.0007905706482679	48.6872097931617	48.6872048041474	48.6746878162623	37.2619168572472	34	38	0	38	0	0	0	0	-8	-1	-3	-5	6	9	17	-0.872593718338399	-0.219896640826873	0.0689490016681357	-0.183802216538789	-0.214659685863874	0.968421052631579	-0.977759472817133	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.221	-1.178	9:9	146/150	D:H	3.88541626053988	0.0002118075877291	1.0488367141091	3.70450062271154	9.3197738725557	893.78337229237	1.68741488635211	1.95392414212297e-07	6.70909230105579	6.91781679568266	2088.84994220519	1.03281930722422e-09	lineage4	dr_mutations_pyrazinamide	GLY	ERR2706989	ERR2706989	lineage4.3.4.2	cd	Democratic Republic of Congo	pnca_p.asp8gly	A	-	ASP	DA8	pnca_complex.pdb
417	D8G	L2	PZA	D	D8	8	G	NA	MDR	DM	hydrophilic	hydrophobic	acidic	neutral	neg	non-polar	3.22	-3.445	-0.851	1.89305	-1.078	-0.82	92	95	-1.187	9	9	5	0.0259067357512953	loop	1.63333333333333	9.48	0.0007905706482679	48.6872097931617	48.6872048041474	48.6746878162623	37.2619168572472	34	38	0	38	0	0	0	0	-8	-1	-3	-5	6	9	17	-0.872593718338399	-0.219896640826873	0.0689490016681357	-0.183802216538789	-0.214659685863874	0.968421052631579	-0.977759472817133	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.221	-1.178	9:9	146/150	D:H	3.88541626053988	0.0002118075877291	1.0488367141091	3.70450062271154	9.3197738725557	893.78337229237	1.68741488635211	1.95392414212297e-07	6.70909230105579	6.91781679568266	2088.84994220519	1.03281930722422e-09	lineage2	dr_mutations_pyrazinamide	GLY	SAMN02414980	SRR1165480_SRR1165595_SRR1163032_SRR1162843	lineage2.2.1	se	Sweden	pnca_p.asp8gly	A	-	ASP	DA8	pnca_complex.pdb
418	D8G	L2	PZA	D	D8	8	G	1	MDR	DM	hydrophilic	hydrophobic	acidic	neutral	neg	non-polar	3.22	-3.445	-0.851	1.89305	-1.078	-0.82	92	95	-1.187	9	9	5	0.0259067357512953	loop	1.63333333333333	9.48	0.0007905706482679	48.6872097931617	48.6872048041474	48.6746878162623	37.2619168572472	34	38	0	38	0	0	0	0	-8	-1	-3	-5	6	9	17	-0.872593718338399	-0.219896640826873	0.0689490016681357	-0.183802216538789	-0.214659685863874	0.968421052631579	-0.977759472817133	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.221	-1.178	9:9	146/150	D:H	3.88541626053988	0.0002118075877291	1.0488367141091	3.70450062271154	9.3197738725557	893.78337229237	1.68741488635211	1.95392414212297e-07	6.70909230105579	6.91781679568266	2088.84994220519	1.03281930722422e-09	lineage2	dr_mutations_pyrazinamide	GLY	ERR2517015	ERR2517015	lineage2.2.1	gb	UK	pnca_p.asp8gly	A	-	ASP	DA8	pnca_complex.pdb
419	D8G	L2	PZA	D	D8	8	G	1	Pre-XDR	DM	hydrophilic	hydrophobic	acidic	neutral	neg	non-polar	3.22	-3.445	-0.851	1.89305	-1.078	-0.82	92	95	-1.187	9	9	5	0.0259067357512953	loop	1.63333333333333	9.48	0.0007905706482679	48.6872097931617	48.6872048041474	48.6746878162623	37.2619168572472	34	38	0	38	0	0	0	0	-8	-1	-3	-5	6	9	17	-0.872593718338399	-0.219896640826873	0.0689490016681357	-0.183802216538789	-0.214659685863874	0.968421052631579	-0.977759472817133	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.221	-1.178	9:9	146/150	D:H	3.88541626053988	0.0002118075877291	1.0488367141091	3.70450062271154	9.3197738725557	893.78337229237	1.68741488635211	1.95392414212297e-07	6.70909230105579	6.91781679568266	2088.84994220519	1.03281930722422e-09	lineage2	dr_mutations_pyrazinamide	GLY	ERR2516213	ERR2516213	lineage2.2.1	be	Belgium	pnca_p.asp8gly	A	-	ASP	DA8	pnca_complex.pdb
420	D8G	L2	PZA	D	D8	8	G	NA	MDR	DM	hydrophilic	hydrophobic	acidic	neutral	neg	non-polar	3.22	-3.445	-0.851	1.89305	-1.078	-0.82	92	95	-1.187	9	9	5	0.0259067357512953	loop	1.63333333333333	9.48	0.0007905706482679	48.6872097931617	48.6872048041474	48.6746878162623	37.2619168572472	34	38	0	38	0	0	0	0	-8	-1	-3	-5	6	9	17	-0.872593718338399	-0.219896640826873	0.0689490016681357	-0.183802216538789	-0.214659685863874	0.968421052631579	-0.977759472817133	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.221	-1.178	9:9	146/150	D:H	3.88541626053988	0.0002118075877291	1.0488367141091	3.70450062271154	9.3197738725557	893.78337229237	1.68741488635211	1.95392414212297e-07	6.70909230105579	6.91781679568266	2088.84994220519	1.03281930722422e-09	lineage2	dr_mutations_pyrazinamide	GLY	SRR8380894	SRR8380894	lineage2.2.1	in	India	pnca_p.asp8gly	A	-	ASP	DA8	pnca_complex.pdb
421	D8G	L2	PZA	D	D8	8	G	1	MDR	DM	hydrophilic	hydrophobic	acidic	neutral	neg	non-polar	3.22	-3.445	-0.851	1.89305	-1.078	-0.82	92	95	-1.187	9	9	5	0.0259067357512953	loop	1.63333333333333	9.48	0.0007905706482679	48.6872097931617	48.6872048041474	48.6746878162623	37.2619168572472	34	38	0	38	0	0	0	0	-8	-1	-3	-5	6	9	17	-0.872593718338399	-0.219896640826873	0.0689490016681357	-0.183802216538789	-0.214659685863874	0.968421052631579	-0.977759472817133	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.221	-1.178	9:9	146/150	D:H	3.88541626053988	0.0002118075877291	1.0488367141091	3.70450062271154	9.3197738725557	893.78337229237	1.68741488635211	1.95392414212297e-07	6.70909230105579	6.91781679568266	2088.84994220519	1.03281930722422e-09	lineage2	dr_mutations_pyrazinamide	GLY	ERR2512979	ERR2512979	lineage2.2.1	gb	UK	pnca_p.asp8gly	A	-	ASP	DA8	pnca_complex.pdb
422	D8G	L2	PZA	D	D8	8	G	NA	Pre-MDR	DM	hydrophilic	hydrophobic	acidic	neutral	neg	non-polar	3.22	-3.445	-0.851	1.89305	-1.078	-0.82	92	95	-1.187	9	9	5	0.0259067357512953	loop	1.63333333333333	9.48	0.0007905706482679	48.6872097931617	48.6872048041474	48.6746878162623	37.2619168572472	34	38	0	38	0	0	0	0	-8	-1	-3	-5	6	9	17	-0.872593718338399	-0.219896640826873	0.0689490016681357	-0.183802216538789	-0.214659685863874	0.968421052631579	-0.977759472817133	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.221	-1.178	9:9	146/150	D:H	3.88541626053988	0.0002118075877291	1.0488367141091	3.70450062271154	9.3197738725557	893.78337229237	1.68741488635211	1.95392414212297e-07	6.70909230105579	6.91781679568266	2088.84994220519	1.03281930722422e-09	lineage2	dr_mutations_pyrazinamide	GLY	BGI_C-xz06202,SRR671728	SRR671728	lineage2.2.1	cn	China	pnca_p.asp8gly	A	-	ASP	DA8	pnca_complex.pdb
423	D8G	L4	PZA	D	D8	8	G	0	MDR	DM	hydrophilic	hydrophobic	acidic	neutral	neg	non-polar	3.22	-3.445	-0.851	1.89305	-1.078	-0.82	92	95	-1.187	9	9	5	0.0259067357512953	loop	1.63333333333333	9.48	0.0007905706482679	48.6872097931617	48.6872048041474	48.6746878162623	37.2619168572472	34	38	0	38	0	0	0	0	-8	-1	-3	-5	6	9	17	-0.872593718338399	-0.219896640826873	0.0689490016681357	-0.183802216538789	-0.214659685863874	0.968421052631579	-0.977759472817133	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.221	-1.178	9:9	146/150	D:H	3.88541626053988	0.0002118075877291	1.0488367141091	3.70450062271154	9.3197738725557	893.78337229237	1.68741488635211	1.95392414212297e-07	6.70909230105579	6.91781679568266	2088.84994220519	1.03281930722422e-09	lineage4	dr_mutations_pyrazinamide	GLY	ERR2516605	ERR2516605	lineage4.1.1.3	pe	Peru	pnca_p.asp8gly	A	-	ASP	DA8	pnca_complex.pdb
424	D8G	L2	PZA	D	D8	8	G	1	Pre-XDR	DM	hydrophilic	hydrophobic	acidic	neutral	neg	non-polar	3.22	-3.445	-0.851	1.89305	-1.078	-0.82	92	95	-1.187	9	9	5	0.0259067357512953	loop	1.63333333333333	9.48	0.0007905706482679	48.6872097931617	48.6872048041474	48.6746878162623	37.2619168572472	34	38	0	38	0	0	0	0	-8	-1	-3	-5	6	9	17	-0.872593718338399	-0.219896640826873	0.0689490016681357	-0.183802216538789	-0.214659685863874	0.968421052631579	-0.977759472817133	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.221	-1.178	9:9	146/150	D:H	3.88541626053988	0.0002118075877291	1.0488367141091	3.70450062271154	9.3197738725557	893.78337229237	1.68741488635211	1.95392414212297e-07	6.70909230105579	6.91781679568266	2088.84994220519	1.03281930722422e-09	lineage2	dr_mutations_pyrazinamide	GLY	ERR2510798	ERR2510798	lineage2.2.1	it	Italy	pnca_p.asp8gly	A	-	ASP	DA8	pnca_complex.pdb
425	D8G	L4	PZA	D	D8	8	G	NA	MDR	DM	hydrophilic	hydrophobic	acidic	neutral	neg	non-polar	3.22	-3.445	-0.851	1.89305	-1.078	-0.82	92	95	-1.187	9	9	5	0.0259067357512953	loop	1.63333333333333	9.48	0.0007905706482679	48.6872097931617	48.6872048041474	48.6746878162623	37.2619168572472	34	38	0	38	0	0	0	0	-8	-1	-3	-5	6	9	17	-0.872593718338399	-0.219896640826873	0.0689490016681357	-0.183802216538789	-0.214659685863874	0.968421052631579	-0.977759472817133	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.221	-1.178	9:9	146/150	D:H	3.88541626053988	0.0002118075877291	1.0488367141091	3.70450062271154	9.3197738725557	893.78337229237	1.68741488635211	1.95392414212297e-07	6.70909230105579	6.91781679568266	2088.84994220519	1.03281930722422e-09	lineage4	dr_mutations_pyrazinamide	GLY	ERR2707209	ERR2707209	lineage4.3.4.2	cd	Democratic Republic of Congo	pnca_p.asp8gly	A	-	ASP	DA8	pnca_complex.pdb
426	D8N	L2	PZA	D	D8	8	N	NA	MDR	DM	hydrophilic	hydrophilic	acidic	neutral	neg	polar	3.22	-1.655	-1.182	-1.26057	-1.022	-1.29	92	95	-1.187	9	9	5	0.0259067357512953	loop	1.63333333333333	9.48	0.0005030904125341	29.1630847029077	29.1630732435187	29.1293325978315	18.6717493808583	0	34	0	34	-4	0	-2	-2	-7	0	-5	-4	0	-4	2	-0.41919959473151	-0.305426356589147	-0.242361378143505	-0.174254049445865	-0.337696335078534	0.968421052631579	-0.977759472817133	Destabilising	Destabilising	Stabilising	Destabilising	Destabilising	effect	-1.221	-1.178	9:9	146/150	D:H	3.37290329402598	0.001789077082818	1.07995768762031	3.12318096596746	4.97876379054103	550.894323519252	1.46483345924118	0.0001485295621003	3.828187099348	3.53443753556636	1331.56873199938	1.55265977742841e-05	lineage2	dr_mutations_pyrazinamide	ASN	ERR2515173	ERR2515173	lineage2.2.1	za	South Africa	pnca_p.asp8asn	A	-	ASP	DA8	pnca_complex.pdb
427	D8N	L2	PZA	D	D8	8	N	NA	XDR	DM	hydrophilic	hydrophilic	acidic	neutral	neg	polar	3.22	-1.655	-1.182	-1.26057	-1.022	-1.29	92	95	-1.187	9	9	5	0.0259067357512953	loop	1.63333333333333	9.48	0.0005030904125341	29.1630847029077	29.1630732435187	29.1293325978315	18.6717493808583	0	34	0	34	-4	0	-2	-2	-7	0	-5	-4	0	-4	2	-0.41919959473151	-0.305426356589147	-0.242361378143505	-0.174254049445865	-0.337696335078534	0.968421052631579	-0.977759472817133	Destabilising	Destabilising	Stabilising	Destabilising	Destabilising	effect	-1.221	-1.178	9:9	146/150	D:H	3.37290329402598	0.001789077082818	1.07995768762031	3.12318096596746	4.97876379054103	550.894323519252	1.46483345924118	0.0001485295621003	3.828187099348	3.53443753556636	1331.56873199938	1.55265977742841e-05	lineage2	dr_mutations_pyrazinamide	ASN	ERR1035078	ERR1035078	lineage2.2.1	za	South Africa	pnca_p.asp8asn	A	-	ASP	DA8	pnca_complex.pdb
428	D8N	L2	PZA	D	D8	8	N	NA	XDR	DM	hydrophilic	hydrophilic	acidic	neutral	neg	polar	3.22	-1.655	-1.182	-1.26057	-1.022	-1.29	92	95	-1.187	9	9	5	0.0259067357512953	loop	1.63333333333333	9.48	0.0005030904125341	29.1630847029077	29.1630732435187	29.1293325978315	18.6717493808583	0	34	0	34	-4	0	-2	-2	-7	0	-5	-4	0	-4	2	-0.41919959473151	-0.305426356589147	-0.242361378143505	-0.174254049445865	-0.337696335078534	0.968421052631579	-0.977759472817133	Destabilising	Destabilising	Stabilising	Destabilising	Destabilising	effect	-1.221	-1.178	9:9	146/150	D:H	3.37290329402598	0.001789077082818	1.07995768762031	3.12318096596746	4.97876379054103	550.894323519252	1.46483345924118	0.0001485295621003	3.828187099348	3.53443753556636	1331.56873199938	1.55265977742841e-05	lineage2	dr_mutations_pyrazinamide	ASN	SAMN02419565	SRR1181019_SRR1184035_SRR1159738_SRR1159790	lineage2.2.1	by	Belarus	pnca_p.asp8asn	A	-	ASP	DA8	pnca_complex.pdb
429	D8N	L2	PZA	D	D8	8	N	NA	XDR	DM	hydrophilic	hydrophilic	acidic	neutral	neg	polar	3.22	-1.655	-1.182	-1.26057	-1.022	-1.29	92	95	-1.187	9	9	5	0.0259067357512953	loop	1.63333333333333	9.48	0.0005030904125341	29.1630847029077	29.1630732435187	29.1293325978315	18.6717493808583	0	34	0	34	-4	0	-2	-2	-7	0	-5	-4	0	-4	2	-0.41919959473151	-0.305426356589147	-0.242361378143505	-0.174254049445865	-0.337696335078534	0.968421052631579	-0.977759472817133	Destabilising	Destabilising	Stabilising	Destabilising	Destabilising	effect	-1.221	-1.178	9:9	146/150	D:H	3.37290329402598	0.001789077082818	1.07995768762031	3.12318096596746	4.97876379054103	550.894323519252	1.46483345924118	0.0001485295621003	3.828187099348	3.53443753556636	1331.56873199938	1.55265977742841e-05	lineage2	dr_mutations_pyrazinamide	ASN	SAMN02419602	SRR1184123_SRR1180984_SRR1159362_SRR1159122	lineage2.2.1	by	Belarus	pnca_p.asp8asn	A	-	ASP	DA8	pnca_complex.pdb
430	D8N	L2	PZA	D	D8	8	N	0	Pre-XDR	DM	hydrophilic	hydrophilic	acidic	neutral	neg	polar	3.22	-1.655	-1.182	-1.26057	-1.022	-1.29	92	95	-1.187	9	9	5	0.0259067357512953	loop	1.63333333333333	9.48	0.0005030904125341	29.1630847029077	29.1630732435187	29.1293325978315	18.6717493808583	0	34	0	34	-4	0	-2	-2	-7	0	-5	-4	0	-4	2	-0.41919959473151	-0.305426356589147	-0.242361378143505	-0.174254049445865	-0.337696335078534	0.968421052631579	-0.977759472817133	Destabilising	Destabilising	Stabilising	Destabilising	Destabilising	effect	-1.221	-1.178	9:9	146/150	D:H	3.37290329402598	0.001789077082818	1.07995768762031	3.12318096596746	4.97876379054103	550.894323519252	1.46483345924118	0.0001485295621003	3.828187099348	3.53443753556636	1331.56873199938	1.55265977742841e-05	lineage2	dr_mutations_pyrazinamide	ASN	ERR2515304	ERR2515304	lineage2.2.1	za	South Africa	pnca_p.asp8asn	A	-	ASP	DA8	pnca_complex.pdb
431	D8N	L2	PZA	D	D8	8	N	NA	XDR	DM	hydrophilic	hydrophilic	acidic	neutral	neg	polar	3.22	-1.655	-1.182	-1.26057	-1.022	-1.29	92	95	-1.187	9	9	5	0.0259067357512953	loop	1.63333333333333	9.48	0.0005030904125341	29.1630847029077	29.1630732435187	29.1293325978315	18.6717493808583	0	34	0	34	-4	0	-2	-2	-7	0	-5	-4	0	-4	2	-0.41919959473151	-0.305426356589147	-0.242361378143505	-0.174254049445865	-0.337696335078534	0.968421052631579	-0.977759472817133	Destabilising	Destabilising	Stabilising	Destabilising	Destabilising	effect	-1.221	-1.178	9:9	146/150	D:H	3.37290329402598	0.001789077082818	1.07995768762031	3.12318096596746	4.97876379054103	550.894323519252	1.46483345924118	0.0001485295621003	3.828187099348	3.53443753556636	1331.56873199938	1.55265977742841e-05	lineage2	dr_mutations_pyrazinamide	ASN	ERR2515589	ERR2515589	lineage2.2.1	za	South Africa	pnca_p.asp8asn	A	-	ASP	DA8	pnca_complex.pdb
432	D8N	L4	PZA	D	D8	8	N	NA	MDR	DM	hydrophilic	hydrophilic	acidic	neutral	neg	polar	3.22	-1.655	-1.182	-1.26057	-1.022	-1.29	92	95	-1.187	9	9	5	0.0259067357512953	loop	1.63333333333333	9.48	0.0005030904125341	29.1630847029077	29.1630732435187	29.1293325978315	18.6717493808583	0	34	0	34	-4	0	-2	-2	-7	0	-5	-4	0	-4	2	-0.41919959473151	-0.305426356589147	-0.242361378143505	-0.174254049445865	-0.337696335078534	0.968421052631579	-0.977759472817133	Destabilising	Destabilising	Stabilising	Destabilising	Destabilising	effect	-1.221	-1.178	9:9	146/150	D:H	3.37290329402598	0.001789077082818	1.07995768762031	3.12318096596746	4.97876379054103	550.894323519252	1.46483345924118	0.0001485295621003	3.828187099348	3.53443753556636	1331.56873199938	1.55265977742841e-05	lineage4	dr_mutations_pyrazinamide	ASN	SAMN02414918	SRR1144735_SRR1163015_SRR1146421_SRR1163040	lineage4.7	se	Sweden	pnca_p.asp8asn	A	-	ASP	DA8	pnca_complex.pdb
433	D8N	L2	PZA	D	D8	8	N	NA	MDR	DM	hydrophilic	hydrophilic	acidic	neutral	neg	polar	3.22	-1.655	-1.182	-1.26057	-1.022	-1.29	92	95	-1.187	9	9	5	0.0259067357512953	loop	1.63333333333333	9.48	0.0005030904125341	29.1630847029077	29.1630732435187	29.1293325978315	18.6717493808583	0	34	0	34	-4	0	-2	-2	-7	0	-5	-4	0	-4	2	-0.41919959473151	-0.305426356589147	-0.242361378143505	-0.174254049445865	-0.337696335078534	0.968421052631579	-0.977759472817133	Destabilising	Destabilising	Stabilising	Destabilising	Destabilising	effect	-1.221	-1.178	9:9	146/150	D:H	3.37290329402598	0.001789077082818	1.07995768762031	3.12318096596746	4.97876379054103	550.894323519252	1.46483345924118	0.0001485295621003	3.828187099348	3.53443753556636	1331.56873199938	1.55265977742841e-05	lineage2	dr_mutations_pyrazinamide	ASN	ERR2515650	ERR2515650	lineage2.2.1	za	South Africa	pnca_p.asp8asn	A	-	ASP	DA8	pnca_complex.pdb
434	D8N	L4	PZA	D	D8	8	N	1	Other	DM	hydrophilic	hydrophilic	acidic	neutral	neg	polar	3.22	-1.655	-1.182	-1.26057	-1.022	-1.29	92	95	-1.187	9	9	5	0.0259067357512953	loop	1.63333333333333	9.48	0.0005030904125341	29.1630847029077	29.1630732435187	29.1293325978315	18.6717493808583	0	34	0	34	-4	0	-2	-2	-7	0	-5	-4	0	-4	2	-0.41919959473151	-0.305426356589147	-0.242361378143505	-0.174254049445865	-0.337696335078534	0.968421052631579	-0.977759472817133	Destabilising	Destabilising	Stabilising	Destabilising	Destabilising	effect	-1.221	-1.178	9:9	146/150	D:H	3.37290329402598	0.001789077082818	1.07995768762031	3.12318096596746	4.97876379054103	550.894323519252	1.46483345924118	0.0001485295621003	3.828187099348	3.53443753556636	1331.56873199938	1.55265977742841e-05	lineage4	dr_mutations_pyrazinamide	ASN	SRR2100844,SAMN03648017	SRR2100844	lineage4.2.1			pnca_p.asp8asn	A	-	ASP	DA8	pnca_complex.pdb
435	D8N	L2	PZA	D	D8	8	N	NA	Pre-XDR	DM	hydrophilic	hydrophilic	acidic	neutral	neg	polar	3.22	-1.655	-1.182	-1.26057	-1.022	-1.29	92	95	-1.187	9	9	5	0.0259067357512953	loop	1.63333333333333	9.48	0.0005030904125341	29.1630847029077	29.1630732435187	29.1293325978315	18.6717493808583	0	34	0	34	-4	0	-2	-2	-7	0	-5	-4	0	-4	2	-0.41919959473151	-0.305426356589147	-0.242361378143505	-0.174254049445865	-0.337696335078534	0.968421052631579	-0.977759472817133	Destabilising	Destabilising	Stabilising	Destabilising	Destabilising	effect	-1.221	-1.178	9:9	146/150	D:H	3.37290329402598	0.001789077082818	1.07995768762031	3.12318096596746	4.97876379054103	550.894323519252	1.46483345924118	0.0001485295621003	3.828187099348	3.53443753556636	1331.56873199938	1.55265977742841e-05	lineage2	dr_mutations_pyrazinamide	ASN	SAMN02419547	SRR1162485_SRR1181247_SRR1159044_SRR1181045	lineage2.2.1	by	Belarus	pnca_p.asp8asn	A	-	ASP	DA8	pnca_complex.pdb
436	D8N	L2	PZA	D	D8	8	N	1	Pre-XDR	DM	hydrophilic	hydrophilic	acidic	neutral	neg	polar	3.22	-1.655	-1.182	-1.26057	-1.022	-1.29	92	95	-1.187	9	9	5	0.0259067357512953	loop	1.63333333333333	9.48	0.0005030904125341	29.1630847029077	29.1630732435187	29.1293325978315	18.6717493808583	0	34	0	34	-4	0	-2	-2	-7	0	-5	-4	0	-4	2	-0.41919959473151	-0.305426356589147	-0.242361378143505	-0.174254049445865	-0.337696335078534	0.968421052631579	-0.977759472817133	Destabilising	Destabilising	Stabilising	Destabilising	Destabilising	effect	-1.221	-1.178	9:9	146/150	D:H	3.37290329402598	0.001789077082818	1.07995768762031	3.12318096596746	4.97876379054103	550.894323519252	1.46483345924118	0.0001485295621003	3.828187099348	3.53443753556636	1331.56873199938	1.55265977742841e-05	lineage2	dr_mutations_pyrazinamide	ASN	ERR1873471	ERR1873471	lineage2.2.1	za	South Africa	pnca_p.asp8asn	A	-	ASP	DA8	pnca_complex.pdb
437	D8N	L2	PZA	D	D8	8	N	1	MDR	DM	hydrophilic	hydrophilic	acidic	neutral	neg	polar	3.22	-1.655	-1.182	-1.26057	-1.022	-1.29	92	95	-1.187	9	9	5	0.0259067357512953	loop	1.63333333333333	9.48	0.0005030904125341	29.1630847029077	29.1630732435187	29.1293325978315	18.6717493808583	0	34	0	34	-4	0	-2	-2	-7	0	-5	-4	0	-4	2	-0.41919959473151	-0.305426356589147	-0.242361378143505	-0.174254049445865	-0.337696335078534	0.968421052631579	-0.977759472817133	Destabilising	Destabilising	Stabilising	Destabilising	Destabilising	effect	-1.221	-1.178	9:9	146/150	D:H	3.37290329402598	0.001789077082818	1.07995768762031	3.12318096596746	4.97876379054103	550.894323519252	1.46483345924118	0.0001485295621003	3.828187099348	3.53443753556636	1331.56873199938	1.55265977742841e-05	lineage2	dr_mutations_pyrazinamide	ASN	ERR2515488	ERR2515488	lineage2.2.1	za	South Africa	pnca_p.asp8asn	A	-	ASP	DA8	pnca_complex.pdb
438	D8N	L4	PZA	D	D8	8	N	NA	MDR	DM	hydrophilic	hydrophilic	acidic	neutral	neg	polar	3.22	-1.655	-1.182	-1.26057	-1.022	-1.29	92	95	-1.187	9	9	5	0.0259067357512953	loop	1.63333333333333	9.48	0.0005030904125341	29.1630847029077	29.1630732435187	29.1293325978315	18.6717493808583	0	34	0	34	-4	0	-2	-2	-7	0	-5	-4	0	-4	2	-0.41919959473151	-0.305426356589147	-0.242361378143505	-0.174254049445865	-0.337696335078534	0.968421052631579	-0.977759472817133	Destabilising	Destabilising	Stabilising	Destabilising	Destabilising	effect	-1.221	-1.178	9:9	146/150	D:H	3.37290329402598	0.001789077082818	1.07995768762031	3.12318096596746	4.97876379054103	550.894323519252	1.46483345924118	0.0001485295621003	3.828187099348	3.53443753556636	1331.56873199938	1.55265977742841e-05	lineage4	dr_mutations_pyrazinamide	ASN	SAMN02414940	SRR1167141_SRR1165398_SRR1166914_SRR1162835	lineage4.7	se	Sweden	pnca_p.asp8asn	A	-	ASP	DA8	pnca_complex.pdb
439	D8N	L4	PZA	D	D8	8	N	NA	MDR	DM	hydrophilic	hydrophilic	acidic	neutral	neg	polar	3.22	-1.655	-1.182	-1.26057	-1.022	-1.29	92	95	-1.187	9	9	5	0.0259067357512953	loop	1.63333333333333	9.48	0.0005030904125341	29.1630847029077	29.1630732435187	29.1293325978315	18.6717493808583	0	34	0	34	-4	0	-2	-2	-7	0	-5	-4	0	-4	2	-0.41919959473151	-0.305426356589147	-0.242361378143505	-0.174254049445865	-0.337696335078534	0.968421052631579	-0.977759472817133	Destabilising	Destabilising	Stabilising	Destabilising	Destabilising	effect	-1.221	-1.178	9:9	146/150	D:H	3.37290329402598	0.001789077082818	1.07995768762031	3.12318096596746	4.97876379054103	550.894323519252	1.46483345924118	0.0001485295621003	3.828187099348	3.53443753556636	1331.56873199938	1.55265977742841e-05	lineage4	dr_mutations_pyrazinamide	ASN	ERR1023402	ERR1023402	lineage4.7			pnca_p.asp8asn	A	-	ASP	DA8	pnca_complex.pdb
440	D8N	L2	PZA	D	D8	8	N	NA	Pre-XDR	DM	hydrophilic	hydrophilic	acidic	neutral	neg	polar	3.22	-1.655	-1.182	-1.26057	-1.022	-1.29	92	95	-1.187	9	9	5	0.0259067357512953	loop	1.63333333333333	9.48	0.0005030904125341	29.1630847029077	29.1630732435187	29.1293325978315	18.6717493808583	0	34	0	34	-4	0	-2	-2	-7	0	-5	-4	0	-4	2	-0.41919959473151	-0.305426356589147	-0.242361378143505	-0.174254049445865	-0.337696335078534	0.968421052631579	-0.977759472817133	Destabilising	Destabilising	Stabilising	Destabilising	Destabilising	effect	-1.221	-1.178	9:9	146/150	D:H	3.37290329402598	0.001789077082818	1.07995768762031	3.12318096596746	4.97876379054103	550.894323519252	1.46483345924118	0.0001485295621003	3.828187099348	3.53443753556636	1331.56873199938	1.55265977742841e-05	lineage2	dr_mutations_pyrazinamide	ASN	ERR1035076	ERR1035076	lineage2.2.1	za	South Africa	pnca_p.asp8asn	A	-	ASP	DA8	pnca_complex.pdb
441	D8N	L2	PZA	D	D8	8	N	NA	MDR	DM	hydrophilic	hydrophilic	acidic	neutral	neg	polar	3.22	-1.655	-1.182	-1.26057	-1.022	-1.29	92	95	-1.187	9	9	5	0.0259067357512953	loop	1.63333333333333	9.48	0.0005030904125341	29.1630847029077	29.1630732435187	29.1293325978315	18.6717493808583	0	34	0	34	-4	0	-2	-2	-7	0	-5	-4	0	-4	2	-0.41919959473151	-0.305426356589147	-0.242361378143505	-0.174254049445865	-0.337696335078534	0.968421052631579	-0.977759472817133	Destabilising	Destabilising	Stabilising	Destabilising	Destabilising	effect	-1.221	-1.178	9:9	146/150	D:H	3.37290329402598	0.001789077082818	1.07995768762031	3.12318096596746	4.97876379054103	550.894323519252	1.46483345924118	0.0001485295621003	3.828187099348	3.53443753556636	1331.56873199938	1.55265977742841e-05	lineage2	dr_mutations_pyrazinamide	ASN	ERR1633956	ERR1633956	lineage2.2.1	za	South Africa	pnca_p.asp8asn	A	-	ASP	DA8	pnca_complex.pdb
442	D8N	L2	PZA	D	D8	8	N	1	XDR	DM	hydrophilic	hydrophilic	acidic	neutral	neg	polar	3.22	-1.655	-1.182	-1.26057	-1.022	-1.29	92	95	-1.187	9	9	5	0.0259067357512953	loop	1.63333333333333	9.48	0.0005030904125341	29.1630847029077	29.1630732435187	29.1293325978315	18.6717493808583	0	34	0	34	-4	0	-2	-2	-7	0	-5	-4	0	-4	2	-0.41919959473151	-0.305426356589147	-0.242361378143505	-0.174254049445865	-0.337696335078534	0.968421052631579	-0.977759472817133	Destabilising	Destabilising	Stabilising	Destabilising	Destabilising	effect	-1.221	-1.178	9:9	146/150	D:H	3.37290329402598	0.001789077082818	1.07995768762031	3.12318096596746	4.97876379054103	550.894323519252	1.46483345924118	0.0001485295621003	3.828187099348	3.53443753556636	1331.56873199938	1.55265977742841e-05	lineage2	dr_mutations_pyrazinamide	ASN	ERR1873477	ERR1873477	lineage2.2.1	za	South Africa	pnca_p.asp8asn	A	-	ASP	DA8	pnca_complex.pdb
443	D8N	L2	PZA	D	D8	8	N	NA	XDR	DM	hydrophilic	hydrophilic	acidic	neutral	neg	polar	3.22	-1.655	-1.182	-1.26057	-1.022	-1.29	92	95	-1.187	9	9	5	0.0259067357512953	loop	1.63333333333333	9.48	0.0005030904125341	29.1630847029077	29.1630732435187	29.1293325978315	18.6717493808583	0	34	0	34	-4	0	-2	-2	-7	0	-5	-4	0	-4	2	-0.41919959473151	-0.305426356589147	-0.242361378143505	-0.174254049445865	-0.337696335078534	0.968421052631579	-0.977759472817133	Destabilising	Destabilising	Stabilising	Destabilising	Destabilising	effect	-1.221	-1.178	9:9	146/150	D:H	3.37290329402598	0.001789077082818	1.07995768762031	3.12318096596746	4.97876379054103	550.894323519252	1.46483345924118	0.0001485295621003	3.828187099348	3.53443753556636	1331.56873199938	1.55265977742841e-05	lineage2	dr_mutations_pyrazinamide	ASN	SAMN02419587	SRR1162498_SRR1181007_SRR1183663_SRR1158950	lineage2.2.1	by	Belarus	pnca_p.asp8asn	A	-	ASP	DA8	pnca_complex.pdb
444	D8N	L2	PZA	D	D8	8	N	NA	MDR	DM	hydrophilic	hydrophilic	acidic	neutral	neg	polar	3.22	-1.655	-1.182	-1.26057	-1.022	-1.29	92	95	-1.187	9	9	5	0.0259067357512953	loop	1.63333333333333	9.48	0.0005030904125341	29.1630847029077	29.1630732435187	29.1293325978315	18.6717493808583	0	34	0	34	-4	0	-2	-2	-7	0	-5	-4	0	-4	2	-0.41919959473151	-0.305426356589147	-0.242361378143505	-0.174254049445865	-0.337696335078534	0.968421052631579	-0.977759472817133	Destabilising	Destabilising	Stabilising	Destabilising	Destabilising	effect	-1.221	-1.178	9:9	146/150	D:H	3.37290329402598	0.001789077082818	1.07995768762031	3.12318096596746	4.97876379054103	550.894323519252	1.46483345924118	0.0001485295621003	3.828187099348	3.53443753556636	1331.56873199938	1.55265977742841e-05	lineage2	dr_mutations_pyrazinamide	ASN	ERR1023521	ERR1023521	lineage2.2.1			pnca_p.asp8asn	A	-	ASP	DA8	pnca_complex.pdb
445	D8N	L4	PZA	D	D8	8	N	NA	Pre-XDR	DM	hydrophilic	hydrophilic	acidic	neutral	neg	polar	3.22	-1.655	-1.182	-1.26057	-1.022	-1.29	92	95	-1.187	9	9	5	0.0259067357512953	loop	1.63333333333333	9.48	0.0005030904125341	29.1630847029077	29.1630732435187	29.1293325978315	18.6717493808583	0	34	0	34	-4	0	-2	-2	-7	0	-5	-4	0	-4	2	-0.41919959473151	-0.305426356589147	-0.242361378143505	-0.174254049445865	-0.337696335078534	0.968421052631579	-0.977759472817133	Destabilising	Destabilising	Stabilising	Destabilising	Destabilising	effect	-1.221	-1.178	9:9	146/150	D:H	3.37290329402598	0.001789077082818	1.07995768762031	3.12318096596746	4.97876379054103	550.894323519252	1.46483345924118	0.0001485295621003	3.828187099348	3.53443753556636	1331.56873199938	1.55265977742841e-05	lineage4	dr_mutations_pyrazinamide	ASN	ERR1193843	ERR1193843	lineage4.3	iq	Iraq	pnca_p.asp8asn	A	-	ASP	DA8	pnca_complex.pdb
446	D8N	L2	PZA	D	D8	8	N	NA	MDR	DM	hydrophilic	hydrophilic	acidic	neutral	neg	polar	3.22	-1.655	-1.182	-1.26057	-1.022	-1.29	92	95	-1.187	9	9	5	0.0259067357512953	loop	1.63333333333333	9.48	0.0005030904125341	29.1630847029077	29.1630732435187	29.1293325978315	18.6717493808583	0	34	0	34	-4	0	-2	-2	-7	0	-5	-4	0	-4	2	-0.41919959473151	-0.305426356589147	-0.242361378143505	-0.174254049445865	-0.337696335078534	0.968421052631579	-0.977759472817133	Destabilising	Destabilising	Stabilising	Destabilising	Destabilising	effect	-1.221	-1.178	9:9	146/150	D:H	3.37290329402598	0.001789077082818	1.07995768762031	3.12318096596746	4.97876379054103	550.894323519252	1.46483345924118	0.0001485295621003	3.828187099348	3.53443753556636	1331.56873199938	1.55265977742841e-05	lineage2	dr_mutations_pyrazinamide	ASN	ERR1633964	ERR1633964	lineage2.2.1	za	South Africa	pnca_p.asp8asn	A	-	ASP	DA8	pnca_complex.pdb
447	D8N	L4	PZA	D	D8	8	N	NA	MDR	DM	hydrophilic	hydrophilic	acidic	neutral	neg	polar	3.22	-1.655	-1.182	-1.26057	-1.022	-1.29	92	95	-1.187	9	9	5	0.0259067357512953	loop	1.63333333333333	9.48	0.0005030904125341	29.1630847029077	29.1630732435187	29.1293325978315	18.6717493808583	0	34	0	34	-4	0	-2	-2	-7	0	-5	-4	0	-4	2	-0.41919959473151	-0.305426356589147	-0.242361378143505	-0.174254049445865	-0.337696335078534	0.968421052631579	-0.977759472817133	Destabilising	Destabilising	Stabilising	Destabilising	Destabilising	effect	-1.221	-1.178	9:9	146/150	D:H	3.37290329402598	0.001789077082818	1.07995768762031	3.12318096596746	4.97876379054103	550.894323519252	1.46483345924118	0.0001485295621003	3.828187099348	3.53443753556636	1331.56873199938	1.55265977742841e-05	lineage4	dr_mutations_pyrazinamide	ASN	SAMN02414943	SRR1167090_SRR1162750_SRR1166808_SRR1165415	lineage4.7	se	Sweden	pnca_p.asp8asn	A	-	ASP	DA8	pnca_complex.pdb
448	D8N	L2	PZA	D	D8	8	N	NA	XDR	DM	hydrophilic	hydrophilic	acidic	neutral	neg	polar	3.22	-1.655	-1.182	-1.26057	-1.022	-1.29	92	95	-1.187	9	9	5	0.0259067357512953	loop	1.63333333333333	9.48	0.0005030904125341	29.1630847029077	29.1630732435187	29.1293325978315	18.6717493808583	0	34	0	34	-4	0	-2	-2	-7	0	-5	-4	0	-4	2	-0.41919959473151	-0.305426356589147	-0.242361378143505	-0.174254049445865	-0.337696335078534	0.968421052631579	-0.977759472817133	Destabilising	Destabilising	Stabilising	Destabilising	Destabilising	effect	-1.221	-1.178	9:9	146/150	D:H	3.37290329402598	0.001789077082818	1.07995768762031	3.12318096596746	4.97876379054103	550.894323519252	1.46483345924118	0.0001485295621003	3.828187099348	3.53443753556636	1331.56873199938	1.55265977742841e-05	lineage2	dr_mutations_pyrazinamide	ASN	ERR2515238	ERR2515238	lineage2.2.1	za	South Africa	pnca_p.asp8asn	A	-	ASP	DA8	pnca_complex.pdb
449	D8N	L2	PZA	D	D8	8	N	1	XDR	DM	hydrophilic	hydrophilic	acidic	neutral	neg	polar	3.22	-1.655	-1.182	-1.26057	-1.022	-1.29	92	95	-1.187	9	9	5	0.0259067357512953	loop	1.63333333333333	9.48	0.0005030904125341	29.1630847029077	29.1630732435187	29.1293325978315	18.6717493808583	0	34	0	34	-4	0	-2	-2	-7	0	-5	-4	0	-4	2	-0.41919959473151	-0.305426356589147	-0.242361378143505	-0.174254049445865	-0.337696335078534	0.968421052631579	-0.977759472817133	Destabilising	Destabilising	Stabilising	Destabilising	Destabilising	effect	-1.221	-1.178	9:9	146/150	D:H	3.37290329402598	0.001789077082818	1.07995768762031	3.12318096596746	4.97876379054103	550.894323519252	1.46483345924118	0.0001485295621003	3.828187099348	3.53443753556636	1331.56873199938	1.55265977742841e-05	lineage2	dr_mutations_pyrazinamide	ASN	ERR1873532	ERR1873532	lineage2.2.1	za	South Africa	pnca_p.asp8asn	A	-	ASP	DA8	pnca_complex.pdb
450	D8N	L2	PZA	D	D8	8	N	1	XDR	DM	hydrophilic	hydrophilic	acidic	neutral	neg	polar	3.22	-1.655	-1.182	-1.26057	-1.022	-1.29	92	95	-1.187	9	9	5	0.0259067357512953	loop	1.63333333333333	9.48	0.0005030904125341	29.1630847029077	29.1630732435187	29.1293325978315	18.6717493808583	0	34	0	34	-4	0	-2	-2	-7	0	-5	-4	0	-4	2	-0.41919959473151	-0.305426356589147	-0.242361378143505	-0.174254049445865	-0.337696335078534	0.968421052631579	-0.977759472817133	Destabilising	Destabilising	Stabilising	Destabilising	Destabilising	effect	-1.221	-1.178	9:9	146/150	D:H	3.37290329402598	0.001789077082818	1.07995768762031	3.12318096596746	4.97876379054103	550.894323519252	1.46483345924118	0.0001485295621003	3.828187099348	3.53443753556636	1331.56873199938	1.55265977742841e-05	lineage2	dr_mutations_pyrazinamide	ASN	ERR2515301	ERR2515301	lineage2.2.1	za	South Africa	pnca_p.asp8asn	A	-	ASP	DA8	pnca_complex.pdb
451	D8N	L2	PZA	D	D8	8	N	NA	Pre-XDR	DM	hydrophilic	hydrophilic	acidic	neutral	neg	polar	3.22	-1.655	-1.182	-1.26057	-1.022	-1.29	92	95	-1.187	9	9	5	0.0259067357512953	loop	1.63333333333333	9.48	0.0005030904125341	29.1630847029077	29.1630732435187	29.1293325978315	18.6717493808583	0	34	0	34	-4	0	-2	-2	-7	0	-5	-4	0	-4	2	-0.41919959473151	-0.305426356589147	-0.242361378143505	-0.174254049445865	-0.337696335078534	0.968421052631579	-0.977759472817133	Destabilising	Destabilising	Stabilising	Destabilising	Destabilising	effect	-1.221	-1.178	9:9	146/150	D:H	3.37290329402598	0.001789077082818	1.07995768762031	3.12318096596746	4.97876379054103	550.894323519252	1.46483345924118	0.0001485295621003	3.828187099348	3.53443753556636	1331.56873199938	1.55265977742841e-05	lineage2	dr_mutations_pyrazinamide	ASN	ERR2515250	ERR2515250	lineage2.2.1	za	South Africa	pnca_p.asp8asn	A	-	ASP	DA8	pnca_complex.pdb
452	V9A	L2	PZA	V	V9	9	A	NA	MDR	DM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	6.555	-1.286	-2.467	2.03689	-2.068	-2.01	61	80	-0.711	8	8	0	0	loop	-0.933333333333333	9.57	0.0002156101768003	0.807902480033628	4.59660271789382e-05	0	0.000393645565148	0	0	0	0	0	0	0	0	2	0	0	2	6	6	5	-0.325734549138804	-0.637467700258398	0.0741879675696938	-0.352600170502984	-0.526178010471204	0.642105263157895	-0.585667215815486	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.827	-0.615	8:7	146/150	I:C:L:V:M	-9.98760797391819	0.930014323968985	113.719344729607	-0.0878268160765962	NA	127.948735098955	-0.0926410587047397	1	0	0	11.7369754738005	0.984170607395186	lineage2	dr_mutations_pyrazinamide	ALA	SRS797047	SRR1723549	lineage2.2.1	cn	China:Hebei	pnca_p.val9ala	A	-	VAL	VA9	pnca_complex.pdb
453	V9A	L4	PZA	V	V9	9	A	NA	MDR	DM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	6.555	-1.286	-2.467	2.03689	-2.068	-2.01	61	80	-0.711	8	8	0	0	loop	-0.933333333333333	9.57	0.0002156101768003	0.807902480033628	4.59660271789382e-05	0	0.000393645565148	0	0	0	0	0	0	0	0	2	0	0	2	6	6	5	-0.325734549138804	-0.637467700258398	0.0741879675696938	-0.352600170502984	-0.526178010471204	0.642105263157895	-0.585667215815486	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.827	-0.615	8:7	146/150	I:C:L:V:M	-9.98760797391819	0.930014323968985	113.719344729607	-0.0878268160765962	NA	127.948735098955	-0.0926410587047397	1	0	0	11.7369754738005	0.984170607395186	lineage4	dr_mutations_pyrazinamide	ALA	SRR671850,BGI_XZ06055	SRR671850	lineage4.5	cn	China	pnca_p.val9ala	A	-	VAL	VA9	pnca_complex.pdb
454	V9A	L2	PZA	V	V9	9	A	0	Pre-XDR	DM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	6.555	-1.286	-2.467	2.03689	-2.068	-2.01	61	80	-0.711	8	8	0	0	loop	-0.933333333333333	9.57	0.0002156101768003	0.807902480033628	4.59660271789382e-05	0	0.000393645565148	0	0	0	0	0	0	0	0	2	0	0	2	6	6	5	-0.325734549138804	-0.637467700258398	0.0741879675696938	-0.352600170502984	-0.526178010471204	0.642105263157895	-0.585667215815486	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.827	-0.615	8:7	146/150	I:C:L:V:M	-9.98760797391819	0.930014323968985	113.719344729607	-0.0878268160765962	NA	127.948735098955	-0.0926410587047397	1	0	0	11.7369754738005	0.984170607395186	lineage2	dr_mutations_pyrazinamide	ALA	SAMN10961402	SRR8651641	lineage2.2.2	cn	China:Wenzhou	pnca_p.val9ala	A	-	VAL	VA9	pnca_complex.pdb
455	V9A	L2	PZA	V	V9	9	A	0	Pre-XDR	DM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	6.555	-1.286	-2.467	2.03689	-2.068	-2.01	61	80	-0.711	8	8	0	0	loop	-0.933333333333333	9.57	0.0002156101768003	0.807902480033628	4.59660271789382e-05	0	0.000393645565148	0	0	0	0	0	0	0	0	2	0	0	2	6	6	5	-0.325734549138804	-0.637467700258398	0.0741879675696938	-0.352600170502984	-0.526178010471204	0.642105263157895	-0.585667215815486	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.827	-0.615	8:7	146/150	I:C:L:V:M	-9.98760797391819	0.930014323968985	113.719344729607	-0.0878268160765962	NA	127.948735098955	-0.0926410587047397	1	0	0	11.7369754738005	0.984170607395186	lineage2	dr_mutations_pyrazinamide	ALA	SAMN10961331	SRR8651653	lineage2.2.2	cn	China:Wenzhou	pnca_p.val9ala	A	-	VAL	VA9	pnca_complex.pdb
456	V9A	L2	PZA	V	V9	9	A	NA	MDR	DM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	6.555	-1.286	-2.467	2.03689	-2.068	-2.01	61	80	-0.711	8	8	0	0	loop	-0.933333333333333	9.57	0.0002156101768003	0.807902480033628	4.59660271789382e-05	0	0.000393645565148	0	0	0	0	0	0	0	0	2	0	0	2	6	6	5	-0.325734549138804	-0.637467700258398	0.0741879675696938	-0.352600170502984	-0.526178010471204	0.642105263157895	-0.585667215815486	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.827	-0.615	8:7	146/150	I:C:L:V:M	-9.98760797391819	0.930014323968985	113.719344729607	-0.0878268160765962	NA	127.948735098955	-0.0926410587047397	1	0	0	11.7369754738005	0.984170607395186	lineage2	dr_mutations_pyrazinamide	ALA	SRR8380932	SRR8380932	lineage2.2.1	in	India	pnca_p.val9ala	A	-	VAL	VA9	pnca_complex.pdb
457	V9A	L2;L4	PZA	V	V9	9	A	0	MDR	DM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	6.555	-1.286	-2.467	2.03689	-2.068	-2.01	61	80	-0.711	8	8	0	0	loop	-0.933333333333333	9.57	0.0002156101768003	0.807902480033628	4.59660271789382e-05	0	0.000393645565148	0	0	0	0	0	0	0	0	2	0	0	2	6	6	5	-0.325734549138804	-0.637467700258398	0.0741879675696938	-0.352600170502984	-0.526178010471204	0.642105263157895	-0.585667215815486	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.827	-0.615	8:7	146/150	I:C:L:V:M	-9.98760797391819	0.930014323968985	113.719344729607	-0.0878268160765962	NA	127.948735098955	-0.0926410587047397	1	0	0	11.7369754738005	0.984170607395186	lineage2;lineage4	dr_mutations_pyrazinamide	ALA	MDR_3208	SRR6824304	lineage4;lineage2.2.1	cn	China: Jize County, Handan City, Hebei Province	pnca_p.val9ala	A	-	VAL	VA9	pnca_complex.pdb
458	V9A	L2	PZA	V	V9	9	A	NA	XDR	DM	hydrophobic	hydrophobic	non-polar	non-polar	non-polar	non-polar	6.555	-1.286	-2.467	2.03689	-2.068	-2.01	61	80	-0.711	8	8	0	0	loop	-0.933333333333333	9.57	0.0002156101768003	0.807902480033628	4.59660271789382e-05	0	0.000393645565148	0	0	0	0	0	0	0	0	2	0	0	2	6	6	5	-0.325734549138804	-0.637467700258398	0.0741879675696938	-0.352600170502984	-0.526178010471204	0.642105263157895	-0.585667215815486	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.827	-0.615	8:7	146/150	I:C:L:V:M	-9.98760797391819	0.930014323968985	113.719344729607	-0.0878268160765962	NA	127.948735098955	-0.0926410587047397	1	0	0	11.7369754738005	0.984170607395186	lineage2	dr_mutations_pyrazinamide	ALA	SRS935963,SAMN03653228	SRR2024922	lineage2.2.1	cn	China	pnca_p.val9ala	A	-	VAL	VA9	pnca_complex.pdb
459	V9G	L3	PZA	V	V9	9	G	1	Pre-XDR	DM	hydrophobic	hydrophobic	non-polar	neutral	non-polar	non-polar	6.555	-1.063	-3.236	3.70952	-3.636	-3.48	83	91	-0.711	8	8	0	0	loop	-0.933333333333333	9.57	0.0003593502946672	19.4256842105263	19.4256680571767	19.4169790983636	9.87561363723508	8	0	0	0	0	0	0	0	0	0	2	-2	4	3	21	-0.269250253292806	-0.836175710594315	0.135108793041907	-0.619948849104859	-0.910994764397906	0.873684210526316	-0.585667215815486	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.827	-0.615	8:7	146/150	I:C:L:V:M	2.96659528728018	0.0079500503166053	1.11770528264822	2.65418382943607	2.87215213651501	380.097158975938	1.28837632444196	0.0036816889015929	2.43395291165754	1.92061868691892	951.403114304703	0.0016748373055023	lineage3	dr_mutations_pyrazinamide	GLY	ERR2510586	ERR2510586	lineage3	pk	Pakistan	pnca_p.val9gly	A	-	VAL	VA9	pnca_complex.pdb
460	V9G	L3	PZA	V	V9	9	G	1	Pre-MDR	DM	hydrophobic	hydrophobic	non-polar	neutral	non-polar	non-polar	6.555	-1.063	-3.236	3.70952	-3.636	-3.48	83	91	-0.711	8	8	0	0	loop	-0.933333333333333	9.57	0.0003593502946672	19.4256842105263	19.4256680571767	19.4169790983636	9.87561363723508	8	0	0	0	0	0	0	0	0	0	2	-2	4	3	21	-0.269250253292806	-0.836175710594315	0.135108793041907	-0.619948849104859	-0.910994764397906	0.873684210526316	-0.585667215815486	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.827	-0.615	8:7	146/150	I:C:L:V:M	2.96659528728018	0.0079500503166053	1.11770528264822	2.65418382943607	2.87215213651501	380.097158975938	1.28837632444196	0.0036816889015929	2.43395291165754	1.92061868691892	951.403114304703	0.0016748373055023	lineage3	dr_mutations_pyrazinamide	GLY	ERR2515261	ERR2515261	lineage3	za	South Africa	pnca_p.val9gly	A	-	VAL	VA9	pnca_complex.pdb
461	V9G	L3	PZA	V	V9	9	G	0	Pre-XDR	DM	hydrophobic	hydrophobic	non-polar	neutral	non-polar	non-polar	6.555	-1.063	-3.236	3.70952	-3.636	-3.48	83	91	-0.711	8	8	0	0	loop	-0.933333333333333	9.57	0.0003593502946672	19.4256842105263	19.4256680571767	19.4169790983636	9.87561363723508	8	0	0	0	0	0	0	0	0	0	2	-2	4	3	21	-0.269250253292806	-0.836175710594315	0.135108793041907	-0.619948849104859	-0.910994764397906	0.873684210526316	-0.585667215815486	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.827	-0.615	8:7	146/150	I:C:L:V:M	2.96659528728018	0.0079500503166053	1.11770528264822	2.65418382943607	2.87215213651501	380.097158975938	1.28837632444196	0.0036816889015929	2.43395291165754	1.92061868691892	951.403114304703	0.0016748373055023	lineage3	dr_mutations_pyrazinamide	GLY	ERR2510469	ERR2510469	lineage3	pk	Pakistan	pnca_p.val9gly	A	-	VAL	VA9	pnca_complex.pdb
462	V9G	L4	PZA	V	V9	9	G	1	MDR	DM	hydrophobic	hydrophobic	non-polar	neutral	non-polar	non-polar	6.555	-1.063	-3.236	3.70952	-3.636	-3.48	83	91	-0.711	8	8	0	0	loop	-0.933333333333333	9.57	0.0003593502946672	19.4256842105263	19.4256680571767	19.4169790983636	9.87561363723508	8	0	0	0	0	0	0	0	0	0	2	-2	4	3	21	-0.269250253292806	-0.836175710594315	0.135108793041907	-0.619948849104859	-0.910994764397906	0.873684210526316	-0.585667215815486	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.827	-0.615	8:7	146/150	I:C:L:V:M	2.96659528728018	0.0079500503166053	1.11770528264822	2.65418382943607	2.87215213651501	380.097158975938	1.28837632444196	0.0036816889015929	2.43395291165754	1.92061868691892	951.403114304703	0.0016748373055023	lineage4	dr_mutations_pyrazinamide	GLY	ERR2516547	ERR2516547	lineage4.1.1	pe	Peru	pnca_p.val9gly	A	-	VAL	VA9	pnca_complex.pdb
463	V9G	L3	PZA	V	V9	9	G	1	Pre-MDR	DM	hydrophobic	hydrophobic	non-polar	neutral	non-polar	non-polar	6.555	-1.063	-3.236	3.70952	-3.636	-3.48	83	91	-0.711	8	8	0	0	loop	-0.933333333333333	9.57	0.0003593502946672	19.4256842105263	19.4256680571767	19.4169790983636	9.87561363723508	8	0	0	0	0	0	0	0	0	0	2	-2	4	3	21	-0.269250253292806	-0.836175710594315	0.135108793041907	-0.619948849104859	-0.910994764397906	0.873684210526316	-0.585667215815486	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-0.827	-0.615	8:7	146/150	I:C:L:V:M	2.96659528728018	0.0079500503166053	1.11770528264822	2.65418382943607	2.87215213651501	380.097158975938	1.28837632444196	0.0036816889015929	2.43395291165754	1.92061868691892	951.403114304703	0.0016748373055023	lineage3	dr_mutations_pyrazinamide	GLY	ERR2516050	ERR2516050	lineage3	za	South Africa	pnca_p.val9gly	A	-	VAL	VA9	pnca_complex.pdb
464	Q10E	L2	PZA	Q	Q10	10	E	NA	XDR	OM	hydrophilic	hydrophilic	neutral	acidic	polar	neg	6.02	-0.537	-2.051	3.84692	-1.976	-0.13	88	91	-1.214	9	9	0	0	strand	-0.933333333333333	8.14	NA	NA	NA	NA	NA	0	-56	0	-56	0	0	2	-2	-4	0	-6	1	0	0	4	-0.136018237082067	-0.529974160206718	0.140113200125292	-0.33691389599318	-0.0340314136125654	0.926315789473684	-1	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.229	-1.201	9:9	147/150	Q	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	lineage2	other_mutations_pyrazinamide	GLU	DRR184878	DRR184878	lineage2.2.1	vn	Vietnam	pnca_p.gln10glu	A	B	GLN	QA10	pnca_complex.pdb
465	Q10E	L2	PZA	Q	Q10	10	E	NA	MDR	OM	hydrophilic	hydrophilic	neutral	acidic	polar	neg	6.02	-0.537	-2.051	3.84692	-1.976	-0.13	88	91	-1.214	9	9	0	0	strand	-0.933333333333333	8.14	NA	NA	NA	NA	NA	0	-56	0	-56	0	0	2	-2	-4	0	-6	1	0	0	4	-0.136018237082067	-0.529974160206718	0.140113200125292	-0.33691389599318	-0.0340314136125654	0.926315789473684	-1	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.229	-1.201	9:9	147/150	Q	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	lineage2	other_mutations_pyrazinamide	GLU	DRR184942	DRR184942	lineage2.2.1	vn	Vietnam	pnca_p.gln10glu	A	B	GLN	QA10	pnca_complex.pdb
466	Q10H	L4	PZA	Q	Q10	10	H	1	MDR	DM	hydrophilic	hydrophobic	neutral	basic	polar	pos	6.02	-0.636	-1.024	3.94633	-1.814	-0.97	91	95	-1.214	9	9	0	0	strand	-0.933333333333333	8.14	0.0007905706482679	107.166385135135	3795803.48336072	Inf	47.6847963834956	4	0	0	0	2	0	2	0	-11	0	-8	-3	0	2	2	-0.161094224924012	-0.264599483204134	0.143733928714516	-0.309292412617221	-0.253926701570681	0.957894736842105	-1	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.229	-1.201	9:9	147/150	Q	15.1494066679727	0.925233417916174	161.432542878774	0.0938435732834176	24.1993753469043	NA	2.03005858162844	3.58120158191569e-09	8.44597123233921	12.2081619622864	Inf	5.00558510128865e-12	lineage4	dr_mutations_pyrazinamide	HIS	436	ERR3014581	lineage4.1.2.1	tn	Tunisia:Bizerte	pnca_p.gln10his	A	B	GLN	QA10	pnca_complex.pdb
467	Q10H	L4	PZA	Q	Q10	10	H	1	MDR	DM	hydrophilic	hydrophobic	neutral	basic	polar	pos	6.02	-0.636	-1.024	3.94633	-1.814	-0.97	91	95	-1.214	9	9	0	0	strand	-0.933333333333333	8.14	0.0007905706482679	107.166385135135	3795803.48336072	Inf	47.6847963834956	4	0	0	0	2	0	2	0	-11	0	-8	-3	0	2	2	-0.161094224924012	-0.264599483204134	0.143733928714516	-0.309292412617221	-0.253926701570681	0.957894736842105	-1	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.229	-1.201	9:9	147/150	Q	15.1494066679727	0.925233417916174	161.432542878774	0.0938435732834176	24.1993753469043	NA	2.03005858162844	3.58120158191569e-09	8.44597123233921	12.2081619622864	Inf	5.00558510128865e-12	lineage4	dr_mutations_pyrazinamide	HIS	3553	ERR3013479	lineage4.1.2.1	tn	Tunisia:Bizerte	pnca_p.gln10his	A	B	GLN	QA10	pnca_complex.pdb
468	Q10H	L4	PZA	Q	Q10	10	H	1	XDR	DM	hydrophilic	hydrophobic	neutral	basic	polar	pos	6.02	-0.636	-1.024	3.94633	-1.814	-0.97	91	95	-1.214	9	9	0	0	strand	-0.933333333333333	8.14	0.0007905706482679	107.166385135135	3795803.48336072	Inf	47.6847963834956	4	0	0	0	2	0	2	0	-11	0	-8	-3	0	2	2	-0.161094224924012	-0.264599483204134	0.143733928714516	-0.309292412617221	-0.253926701570681	0.957894736842105	-1	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.229	-1.201	9:9	147/150	Q	15.1494066679727	0.925233417916174	161.432542878774	0.0938435732834176	24.1993753469043	NA	2.03005858162844	3.58120158191569e-09	8.44597123233921	12.2081619622864	Inf	5.00558510128865e-12	lineage4	dr_mutations_pyrazinamide	HIS	8626	ERR3014594	lineage4.1.2.1	tn	Tunisia:Bizerte	pnca_p.gln10his	A	B	GLN	QA10	pnca_complex.pdb
469	Q10H	L4	PZA	Q	Q10	10	H	1	MDR	DM	hydrophilic	hydrophobic	neutral	basic	polar	pos	6.02	-0.636	-1.024	3.94633	-1.814	-0.97	91	95	-1.214	9	9	0	0	strand	-0.933333333333333	8.14	0.0007905706482679	107.166385135135	3795803.48336072	Inf	47.6847963834956	4	0	0	0	2	0	2	0	-11	0	-8	-3	0	2	2	-0.161094224924012	-0.264599483204134	0.143733928714516	-0.309292412617221	-0.253926701570681	0.957894736842105	-1	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.229	-1.201	9:9	147/150	Q	15.1494066679727	0.925233417916174	161.432542878774	0.0938435732834176	24.1993753469043	NA	2.03005858162844	3.58120158191569e-09	8.44597123233921	12.2081619622864	Inf	5.00558510128865e-12	lineage4	dr_mutations_pyrazinamide	HIS	8649	ERR3014595	lineage4.1.2.1	tn	Tunisia:Bizerte	pnca_p.gln10his	A	B	GLN	QA10	pnca_complex.pdb
470	Q10H	L4	PZA	Q	Q10	10	H	1	MDR	DM	hydrophilic	hydrophobic	neutral	basic	polar	pos	6.02	-0.636	-1.024	3.94633	-1.814	-0.97	91	95	-1.214	9	9	0	0	strand	-0.933333333333333	8.14	0.0007905706482679	107.166385135135	3795803.48336072	Inf	47.6847963834956	4	0	0	0	2	0	2	0	-11	0	-8	-3	0	2	2	-0.161094224924012	-0.264599483204134	0.143733928714516	-0.309292412617221	-0.253926701570681	0.957894736842105	-1	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.229	-1.201	9:9	147/150	Q	15.1494066679727	0.925233417916174	161.432542878774	0.0938435732834176	24.1993753469043	NA	2.03005858162844	3.58120158191569e-09	8.44597123233921	12.2081619622864	Inf	5.00558510128865e-12	lineage4	dr_mutations_pyrazinamide	HIS	13025	ERR3014604	lineage4.1.2.1	tn	Tunisia:Bizerte	pnca_p.gln10his	A	B	GLN	QA10	pnca_complex.pdb
471	Q10H	L4	PZA	Q	Q10	10	H	1	Pre-XDR	DM	hydrophilic	hydrophobic	neutral	basic	polar	pos	6.02	-0.636	-1.024	3.94633	-1.814	-0.97	91	95	-1.214	9	9	0	0	strand	-0.933333333333333	8.14	0.0007905706482679	107.166385135135	3795803.48336072	Inf	47.6847963834956	4	0	0	0	2	0	2	0	-11	0	-8	-3	0	2	2	-0.161094224924012	-0.264599483204134	0.143733928714516	-0.309292412617221	-0.253926701570681	0.957894736842105	-1	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.229	-1.201	9:9	147/150	Q	15.1494066679727	0.925233417916174	161.432542878774	0.0938435732834176	24.1993753469043	NA	2.03005858162844	3.58120158191569e-09	8.44597123233921	12.2081619622864	Inf	5.00558510128865e-12	lineage4	dr_mutations_pyrazinamide	HIS	10942	ERR3014599	lineage4.1.2.1	tn	Tunisia:Bizerte	pnca_p.gln10his	A	B	GLN	QA10	pnca_complex.pdb
472	Q10H	L2	PZA	Q	Q10	10	H	1	Pre-XDR	DM	hydrophilic	hydrophobic	neutral	basic	polar	pos	6.02	-0.636	-1.024	3.94633	-1.814	-0.97	91	95	-1.214	9	9	0	0	strand	-0.933333333333333	8.14	0.0007905706482679	107.166385135135	3795803.48336072	Inf	47.6847963834956	4	0	0	0	2	0	2	0	-11	0	-8	-3	0	2	2	-0.161094224924012	-0.264599483204134	0.143733928714516	-0.309292412617221	-0.253926701570681	0.957894736842105	-1	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.229	-1.201	9:9	147/150	Q	15.1494066679727	0.925233417916174	161.432542878774	0.0938435732834176	24.1993753469043	NA	2.03005858162844	3.58120158191569e-09	8.44597123233921	12.2081619622864	Inf	5.00558510128865e-12	lineage2	dr_mutations_pyrazinamide	HIS	MDR_19329	SRR6824407	lineage2.2.1	cn	China: Luoding City, Yunfu City, Guangdong Province	pnca_p.gln10his	A	B	GLN	QA10	pnca_complex.pdb
473	Q10H	L2	PZA	Q	Q10	10	H	1	XDR	DM	hydrophilic	hydrophobic	neutral	basic	polar	pos	6.02	-0.636	-1.024	3.94633	-1.814	-0.97	91	95	-1.214	9	9	0	0	strand	-0.933333333333333	8.14	0.0007905706482679	107.166385135135	3795803.48336072	Inf	47.6847963834956	4	0	0	0	2	0	2	0	-11	0	-8	-3	0	2	2	-0.161094224924012	-0.264599483204134	0.143733928714516	-0.309292412617221	-0.253926701570681	0.957894736842105	-1	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.229	-1.201	9:9	147/150	Q	15.1494066679727	0.925233417916174	161.432542878774	0.0938435732834176	24.1993753469043	NA	2.03005858162844	3.58120158191569e-09	8.44597123233921	12.2081619622864	Inf	5.00558510128865e-12	lineage2	dr_mutations_pyrazinamide	HIS	ERR2516546	ERR2516546	lineage2.2.1	pe	Peru	pnca_p.gln10his	A	B	GLN	QA10	pnca_complex.pdb
474	Q10H	L4	PZA	Q	Q10	10	H	1	MDR	DM	hydrophilic	hydrophobic	neutral	basic	polar	pos	6.02	-0.636	-1.024	3.94633	-1.814	-0.97	91	95	-1.214	9	9	0	0	strand	-0.933333333333333	8.14	0.0007905706482679	107.166385135135	3795803.48336072	Inf	47.6847963834956	4	0	0	0	2	0	2	0	-11	0	-8	-3	0	2	2	-0.161094224924012	-0.264599483204134	0.143733928714516	-0.309292412617221	-0.253926701570681	0.957894736842105	-1	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.229	-1.201	9:9	147/150	Q	15.1494066679727	0.925233417916174	161.432542878774	0.0938435732834176	24.1993753469043	NA	2.03005858162844	3.58120158191569e-09	8.44597123233921	12.2081619622864	Inf	5.00558510128865e-12	lineage4	dr_mutations_pyrazinamide	HIS	2109	ERR3014583	lineage4.1.2.1	tn	Tunisia:Bizerte	pnca_p.gln10his	A	B	GLN	QA10	pnca_complex.pdb
475	Q10H	L4	PZA	Q	Q10	10	H	1	XDR	DM	hydrophilic	hydrophobic	neutral	basic	polar	pos	6.02	-0.636	-1.024	3.94633	-1.814	-0.97	91	95	-1.214	9	9	0	0	strand	-0.933333333333333	8.14	0.0007905706482679	107.166385135135	3795803.48336072	Inf	47.6847963834956	4	0	0	0	2	0	2	0	-11	0	-8	-3	0	2	2	-0.161094224924012	-0.264599483204134	0.143733928714516	-0.309292412617221	-0.253926701570681	0.957894736842105	-1	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.229	-1.201	9:9	147/150	Q	15.1494066679727	0.925233417916174	161.432542878774	0.0938435732834176	24.1993753469043	NA	2.03005858162844	3.58120158191569e-09	8.44597123233921	12.2081619622864	Inf	5.00558510128865e-12	lineage4	dr_mutations_pyrazinamide	HIS	14666	ERR3014613	lineage4.1.2.1	tn	Tunisia:Bizerte	pnca_p.gln10his	A	B	GLN	QA10	pnca_complex.pdb
476	Q10H	L4	PZA	Q	Q10	10	H	1	MDR	DM	hydrophilic	hydrophobic	neutral	basic	polar	pos	6.02	-0.636	-1.024	3.94633	-1.814	-0.97	91	95	-1.214	9	9	0	0	strand	-0.933333333333333	8.14	0.0007905706482679	107.166385135135	3795803.48336072	Inf	47.6847963834956	4	0	0	0	2	0	2	0	-11	0	-8	-3	0	2	2	-0.161094224924012	-0.264599483204134	0.143733928714516	-0.309292412617221	-0.253926701570681	0.957894736842105	-1	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.229	-1.201	9:9	147/150	Q	15.1494066679727	0.925233417916174	161.432542878774	0.0938435732834176	24.1993753469043	NA	2.03005858162844	3.58120158191569e-09	8.44597123233921	12.2081619622864	Inf	5.00558510128865e-12	lineage4	dr_mutations_pyrazinamide	HIS	5069	ERR3014587	lineage4.1.2.1	tn	Tunisia:Bizerte	pnca_p.gln10his	A	B	GLN	QA10	pnca_complex.pdb
477	Q10H	L2	PZA	Q	Q10	10	H	NA	Pre-XDR	DM	hydrophilic	hydrophobic	neutral	basic	polar	pos	6.02	-0.636	-1.024	3.94633	-1.814	-0.97	91	95	-1.214	9	9	0	0	strand	-0.933333333333333	8.14	0.0007905706482679	107.166385135135	3795803.48336072	Inf	47.6847963834956	4	0	0	0	2	0	2	0	-11	0	-8	-3	0	2	2	-0.161094224924012	-0.264599483204134	0.143733928714516	-0.309292412617221	-0.253926701570681	0.957894736842105	-1	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.229	-1.201	9:9	147/150	Q	15.1494066679727	0.925233417916174	161.432542878774	0.0938435732834176	24.1993753469043	NA	2.03005858162844	3.58120158191569e-09	8.44597123233921	12.2081619622864	Inf	5.00558510128865e-12	lineage2	dr_mutations_pyrazinamide	HIS	SRS797051	SRR1723552	lineage2.2.1	cn	China:Guangdong	pnca_p.gln10his	A	B	GLN	QA10	pnca_complex.pdb
478	Q10L	L4	PZA	Q	Q10	10	L	NA	Pre-XDR	OM	hydrophilic	hydrophobic	neutral	non-polar	polar	non-polar	6.02	-1.694	0.641	0.169275	-0.188	0.05	91	95	-1.214	9	9	0	0	strand	-0.933333333333333	8.14	NA	NA	NA	NA	NA	20	0	0	0	4	0	4	0	-3	0	-3	-3	2	6	4	-0.429078014184397	0.545068027210884	0.00616536396681211	-0.0320545609548167	0.0280898876404494	0.957894736842105	-1	Destabilising	Stabilising	Destabilising	Destabilising	Stabilising	effect	-1.229	-1.201	9:9	147/150	Q	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	lineage4	other_mutations_pyrazinamide	LEU	SAMN02567710	SRR1166324	lineage4.1.2.1	ro	Romania	pnca_p.gln10leu	A	B	GLN	QA10	pnca_complex.pdb
479	Q10P	L4	PZA	Q	Q10	10	P	1	Pre-XDR	DM	hydrophilic	hydrophilic	neutral	non-polar	polar	non-polar	6.02	-1.771	-0.631	6.78299	-2.963	-0.11	95	95	-1.214	9	9	0	0	strand	-0.933333333333333	8.14	0.0211297973264338	156.233890214797	156.233722233267	156.382472756358	1333.51093453962	38	-2	0	-2	6	2	4	0	-8	2	-6	-4	0	2	0	-0.448581560283688	-0.163049095607235	0.247051260571537	-0.505200341005968	-0.0287958115183246	1	-1	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.229	-1.201	9:9	147/150	Q	5.05135310548255	2.49562215648785e-55	0.322395320006857	15.6681961306855	87.7376148601903	314.979076956589	2.19377524680641	1.27822918710216e-207	206.893391269988	83.6783303393677	330.782028899935	5.90060424845557e-292	lineage4	dr_mutations_pyrazinamide	PRO	ERR760750	ERR760750	lineage4.1.2.1	ar	Argentina	pnca_p.gln10pro	A	B	GLN	QA10	pnca_complex.pdb
480	Q10P	L4	PZA	Q	Q10	10	P	1	Pre-XDR	DM	hydrophilic	hydrophilic	neutral	non-polar	polar	non-polar	6.02	-1.771	-0.631	6.78299	-2.963	-0.11	95	95	-1.214	9	9	0	0	strand	-0.933333333333333	8.14	0.0211297973264338	156.233890214797	156.233722233267	156.382472756358	1333.51093453962	38	-2	0	-2	6	2	4	0	-8	2	-6	-4	0	2	0	-0.448581560283688	-0.163049095607235	0.247051260571537	-0.505200341005968	-0.0287958115183246	1	-1	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.229	-1.201	9:9	147/150	Q	5.05135310548255	2.49562215648785e-55	0.322395320006857	15.6681961306855	87.7376148601903	314.979076956589	2.19377524680641	1.27822918710216e-207	206.893391269988	83.6783303393677	330.782028899935	5.90060424845557e-292	lineage4	dr_mutations_pyrazinamide	PRO	ERR760884	ERR760884	lineage4.1.2.1	ar	Argentina	pnca_p.gln10pro	A	B	GLN	QA10	pnca_complex.pdb
481	Q10P	L4	PZA	Q	Q10	10	P	1	Pre-XDR	DM	hydrophilic	hydrophilic	neutral	non-polar	polar	non-polar	6.02	-1.771	-0.631	6.78299	-2.963	-0.11	95	95	-1.214	9	9	0	0	strand	-0.933333333333333	8.14	0.0211297973264338	156.233890214797	156.233722233267	156.382472756358	1333.51093453962	38	-2	0	-2	6	2	4	0	-8	2	-6	-4	0	2	0	-0.448581560283688	-0.163049095607235	0.247051260571537	-0.505200341005968	-0.0287958115183246	1	-1	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.229	-1.201	9:9	147/150	Q	5.05135310548255	2.49562215648785e-55	0.322395320006857	15.6681961306855	87.7376148601903	314.979076956589	2.19377524680641	1.27822918710216e-207	206.893391269988	83.6783303393677	330.782028899935	5.90060424845557e-292	lineage4	dr_mutations_pyrazinamide	PRO	ERR757161	ERR757161	lineage4.1.2.1	ar	Argentina	pnca_p.gln10pro	A	B	GLN	QA10	pnca_complex.pdb
482	Q10P	L4	PZA	Q	Q10	10	P	1	Pre-XDR	DM	hydrophilic	hydrophilic	neutral	non-polar	polar	non-polar	6.02	-1.771	-0.631	6.78299	-2.963	-0.11	95	95	-1.214	9	9	0	0	strand	-0.933333333333333	8.14	0.0211297973264338	156.233890214797	156.233722233267	156.382472756358	1333.51093453962	38	-2	0	-2	6	2	4	0	-8	2	-6	-4	0	2	0	-0.448581560283688	-0.163049095607235	0.247051260571537	-0.505200341005968	-0.0287958115183246	1	-1	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.229	-1.201	9:9	147/150	Q	5.05135310548255	2.49562215648785e-55	0.322395320006857	15.6681961306855	87.7376148601903	314.979076956589	2.19377524680641	1.27822918710216e-207	206.893391269988	83.6783303393677	330.782028899935	5.90060424845557e-292	lineage4	dr_mutations_pyrazinamide	PRO	ERR760867	ERR760867	lineage4.1.2.1	ar	Argentina	pnca_p.gln10pro	A	B	GLN	QA10	pnca_complex.pdb
483	Q10P	L2	PZA	Q	Q10	10	P	NA	Pre-XDR	DM	hydrophilic	hydrophilic	neutral	non-polar	polar	non-polar	6.02	-1.771	-0.631	6.78299	-2.963	-0.11	95	95	-1.214	9	9	0	0	strand	-0.933333333333333	8.14	0.0211297973264338	156.233890214797	156.233722233267	156.382472756358	1333.51093453962	38	-2	0	-2	6	2	4	0	-8	2	-6	-4	0	2	0	-0.448581560283688	-0.163049095607235	0.247051260571537	-0.505200341005968	-0.0287958115183246	1	-1	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.229	-1.201	9:9	147/150	Q	5.05135310548255	2.49562215648785e-55	0.322395320006857	15.6681961306855	87.7376148601903	314.979076956589	2.19377524680641	1.27822918710216e-207	206.893391269988	83.6783303393677	330.782028899935	5.90060424845557e-292	lineage2	dr_mutations_pyrazinamide	PRO	SAMN02360601	SRR1049039_SRR1013645_SRR1013644_SRR1049038	lineage2.2.2	kr	South Korea	pnca_p.gln10pro	A	B	GLN	QA10	pnca_complex.pdb
484	Q10P	L4	PZA	Q	Q10	10	P	1	Pre-XDR	DM	hydrophilic	hydrophilic	neutral	non-polar	polar	non-polar	6.02	-1.771	-0.631	6.78299	-2.963	-0.11	95	95	-1.214	9	9	0	0	strand	-0.933333333333333	8.14	0.0211297973264338	156.233890214797	156.233722233267	156.382472756358	1333.51093453962	38	-2	0	-2	6	2	4	0	-8	2	-6	-4	0	2	0	-0.448581560283688	-0.163049095607235	0.247051260571537	-0.505200341005968	-0.0287958115183246	1	-1	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.229	-1.201	9:9	147/150	Q	5.05135310548255	2.49562215648785e-55	0.322395320006857	15.6681961306855	87.7376148601903	314.979076956589	2.19377524680641	1.27822918710216e-207	206.893391269988	83.6783303393677	330.782028899935	5.90060424845557e-292	lineage4	dr_mutations_pyrazinamide	PRO	ERR757145	ERR757145	lineage4.1.2.1	ar	Argentina	pnca_p.gln10pro	A	B	GLN	QA10	pnca_complex.pdb
485	Q10P	L4	PZA	Q	Q10	10	P	1	MDR	DM	hydrophilic	hydrophilic	neutral	non-polar	polar	non-polar	6.02	-1.771	-0.631	6.78299	-2.963	-0.11	95	95	-1.214	9	9	0	0	strand	-0.933333333333333	8.14	0.0211297973264338	156.233890214797	156.233722233267	156.382472756358	1333.51093453962	38	-2	0	-2	6	2	4	0	-8	2	-6	-4	0	2	0	-0.448581560283688	-0.163049095607235	0.247051260571537	-0.505200341005968	-0.0287958115183246	1	-1	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.229	-1.201	9:9	147/150	Q	5.05135310548255	2.49562215648785e-55	0.322395320006857	15.6681961306855	87.7376148601903	314.979076956589	2.19377524680641	1.27822918710216e-207	206.893391269988	83.6783303393677	330.782028899935	5.90060424845557e-292	lineage4	dr_mutations_pyrazinamide	PRO	ERS457454	ERR551592_ERR551591	lineage4.8	uz	Nukus	pnca_p.gln10pro	A	B	GLN	QA10	pnca_complex.pdb
486	Q10P	L4	PZA	Q	Q10	10	P	1	Pre-XDR	DM	hydrophilic	hydrophilic	neutral	non-polar	polar	non-polar	6.02	-1.771	-0.631	6.78299	-2.963	-0.11	95	95	-1.214	9	9	0	0	strand	-0.933333333333333	8.14	0.0211297973264338	156.233890214797	156.233722233267	156.382472756358	1333.51093453962	38	-2	0	-2	6	2	4	0	-8	2	-6	-4	0	2	0	-0.448581560283688	-0.163049095607235	0.247051260571537	-0.505200341005968	-0.0287958115183246	1	-1	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.229	-1.201	9:9	147/150	Q	5.05135310548255	2.49562215648785e-55	0.322395320006857	15.6681961306855	87.7376148601903	314.979076956589	2.19377524680641	1.27822918710216e-207	206.893391269988	83.6783303393677	330.782028899935	5.90060424845557e-292	lineage4	dr_mutations_pyrazinamide	PRO	ERR760838	ERR760838	lineage4.1.2.1	ar	Argentina	pnca_p.gln10pro	A	B	GLN	QA10	pnca_complex.pdb
487	Q10P	L4	PZA	Q	Q10	10	P	1	XDR	DM	hydrophilic	hydrophilic	neutral	non-polar	polar	non-polar	6.02	-1.771	-0.631	6.78299	-2.963	-0.11	95	95	-1.214	9	9	0	0	strand	-0.933333333333333	8.14	0.0211297973264338	156.233890214797	156.233722233267	156.382472756358	1333.51093453962	38	-2	0	-2	6	2	4	0	-8	2	-6	-4	0	2	0	-0.448581560283688	-0.163049095607235	0.247051260571537	-0.505200341005968	-0.0287958115183246	1	-1	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.229	-1.201	9:9	147/150	Q	5.05135310548255	2.49562215648785e-55	0.322395320006857	15.6681961306855	87.7376148601903	314.979076956589	2.19377524680641	1.27822918710216e-207	206.893391269988	83.6783303393677	330.782028899935	5.90060424845557e-292	lineage4	dr_mutations_pyrazinamide	PRO	ERR760823	ERR760823	lineage4.1.2.1	ar	Argentina	pnca_p.gln10pro	A	B	GLN	QA10	pnca_complex.pdb
488	Q10P	L4	PZA	Q	Q10	10	P	1	Pre-XDR	DM	hydrophilic	hydrophilic	neutral	non-polar	polar	non-polar	6.02	-1.771	-0.631	6.78299	-2.963	-0.11	95	95	-1.214	9	9	0	0	strand	-0.933333333333333	8.14	0.0211297973264338	156.233890214797	156.233722233267	156.382472756358	1333.51093453962	38	-2	0	-2	6	2	4	0	-8	2	-6	-4	0	2	0	-0.448581560283688	-0.163049095607235	0.247051260571537	-0.505200341005968	-0.0287958115183246	1	-1	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.229	-1.201	9:9	147/150	Q	5.05135310548255	2.49562215648785e-55	0.322395320006857	15.6681961306855	87.7376148601903	314.979076956589	2.19377524680641	1.27822918710216e-207	206.893391269988	83.6783303393677	330.782028899935	5.90060424845557e-292	lineage4	dr_mutations_pyrazinamide	PRO	ERR760881	ERR760881	lineage4.1.2.1	ar	Argentina	pnca_p.gln10pro	A	B	GLN	QA10	pnca_complex.pdb
489	Q10P	L1	PZA	Q	Q10	10	P	NA	MDR	DM	hydrophilic	hydrophilic	neutral	non-polar	polar	non-polar	6.02	-1.771	-0.631	6.78299	-2.963	-0.11	95	95	-1.214	9	9	0	0	strand	-0.933333333333333	8.14	0.0211297973264338	156.233890214797	156.233722233267	156.382472756358	1333.51093453962	38	-2	0	-2	6	2	4	0	-8	2	-6	-4	0	2	0	-0.448581560283688	-0.163049095607235	0.247051260571537	-0.505200341005968	-0.0287958115183246	1	-1	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.229	-1.201	9:9	147/150	Q	5.05135310548255	2.49562215648785e-55	0.322395320006857	15.6681961306855	87.7376148601903	314.979076956589	2.19377524680641	1.27822918710216e-207	206.893391269988	83.6783303393677	330.782028899935	5.90060424845557e-292	lineage1	dr_mutations_pyrazinamide	PRO	SRR8380876	SRR8380876	lineage1.1.2	in	India	pnca_p.gln10pro	A	B	GLN	QA10	pnca_complex.pdb
490	Q10P	L4	PZA	Q	Q10	10	P	1	Pre-XDR	DM	hydrophilic	hydrophilic	neutral	non-polar	polar	non-polar	6.02	-1.771	-0.631	6.78299	-2.963	-0.11	95	95	-1.214	9	9	0	0	strand	-0.933333333333333	8.14	0.0211297973264338	156.233890214797	156.233722233267	156.382472756358	1333.51093453962	38	-2	0	-2	6	2	4	0	-8	2	-6	-4	0	2	0	-0.448581560283688	-0.163049095607235	0.247051260571537	-0.505200341005968	-0.0287958115183246	1	-1	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.229	-1.201	9:9	147/150	Q	5.05135310548255	2.49562215648785e-55	0.322395320006857	15.6681961306855	87.7376148601903	314.979076956589	2.19377524680641	1.27822918710216e-207	206.893391269988	83.6783303393677	330.782028899935	5.90060424845557e-292	lineage4	dr_mutations_pyrazinamide	PRO	ERR757162	ERR757162	lineage4.1.2.1	ar	Argentina	pnca_p.gln10pro	A	B	GLN	QA10	pnca_complex.pdb
491	Q10P	L4	PZA	Q	Q10	10	P	1	Pre-XDR	DM	hydrophilic	hydrophilic	neutral	non-polar	polar	non-polar	6.02	-1.771	-0.631	6.78299	-2.963	-0.11	95	95	-1.214	9	9	0	0	strand	-0.933333333333333	8.14	0.0211297973264338	156.233890214797	156.233722233267	156.382472756358	1333.51093453962	38	-2	0	-2	6	2	4	0	-8	2	-6	-4	0	2	0	-0.448581560283688	-0.163049095607235	0.247051260571537	-0.505200341005968	-0.0287958115183246	1	-1	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.229	-1.201	9:9	147/150	Q	5.05135310548255	2.49562215648785e-55	0.322395320006857	15.6681961306855	87.7376148601903	314.979076956589	2.19377524680641	1.27822918710216e-207	206.893391269988	83.6783303393677	330.782028899935	5.90060424845557e-292	lineage4	dr_mutations_pyrazinamide	PRO	ERR760738	ERR760738	lineage4.1.2.1	ar	Argentina	pnca_p.gln10pro	A	B	GLN	QA10	pnca_complex.pdb
492	Q10P	L4	PZA	Q	Q10	10	P	1	Pre-XDR	DM	hydrophilic	hydrophilic	neutral	non-polar	polar	non-polar	6.02	-1.771	-0.631	6.78299	-2.963	-0.11	95	95	-1.214	9	9	0	0	strand	-0.933333333333333	8.14	0.0211297973264338	156.233890214797	156.233722233267	156.382472756358	1333.51093453962	38	-2	0	-2	6	2	4	0	-8	2	-6	-4	0	2	0	-0.448581560283688	-0.163049095607235	0.247051260571537	-0.505200341005968	-0.0287958115183246	1	-1	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.229	-1.201	9:9	147/150	Q	5.05135310548255	2.49562215648785e-55	0.322395320006857	15.6681961306855	87.7376148601903	314.979076956589	2.19377524680641	1.27822918710216e-207	206.893391269988	83.6783303393677	330.782028899935	5.90060424845557e-292	lineage4	dr_mutations_pyrazinamide	PRO	ERR760822	ERR760822	lineage4.1.2.1	ar	Argentina	pnca_p.gln10pro	A	B	GLN	QA10	pnca_complex.pdb
493	Q10P	L4	PZA	Q	Q10	10	P	1	XDR	DM	hydrophilic	hydrophilic	neutral	non-polar	polar	non-polar	6.02	-1.771	-0.631	6.78299	-2.963	-0.11	95	95	-1.214	9	9	0	0	strand	-0.933333333333333	8.14	0.0211297973264338	156.233890214797	156.233722233267	156.382472756358	1333.51093453962	38	-2	0	-2	6	2	4	0	-8	2	-6	-4	0	2	0	-0.448581560283688	-0.163049095607235	0.247051260571537	-0.505200341005968	-0.0287958115183246	1	-1	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.229	-1.201	9:9	147/150	Q	5.05135310548255	2.49562215648785e-55	0.322395320006857	15.6681961306855	87.7376148601903	314.979076956589	2.19377524680641	1.27822918710216e-207	206.893391269988	83.6783303393677	330.782028899935	5.90060424845557e-292	lineage4	dr_mutations_pyrazinamide	PRO	ERR760795	ERR760795	lineage4.1.2.1	ar	Argentina	pnca_p.gln10pro	A	B	GLN	QA10	pnca_complex.pdb
494	Q10P	L4	PZA	Q	Q10	10	P	1	Pre-XDR	DM	hydrophilic	hydrophilic	neutral	non-polar	polar	non-polar	6.02	-1.771	-0.631	6.78299	-2.963	-0.11	95	95	-1.214	9	9	0	0	strand	-0.933333333333333	8.14	0.0211297973264338	156.233890214797	156.233722233267	156.382472756358	1333.51093453962	38	-2	0	-2	6	2	4	0	-8	2	-6	-4	0	2	0	-0.448581560283688	-0.163049095607235	0.247051260571537	-0.505200341005968	-0.0287958115183246	1	-1	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.229	-1.201	9:9	147/150	Q	5.05135310548255	2.49562215648785e-55	0.322395320006857	15.6681961306855	87.7376148601903	314.979076956589	2.19377524680641	1.27822918710216e-207	206.893391269988	83.6783303393677	330.782028899935	5.90060424845557e-292	lineage4	dr_mutations_pyrazinamide	PRO	ERR760799	ERR760799	lineage4.1.2.1	ar	Argentina	pnca_p.gln10pro	A	B	GLN	QA10	pnca_complex.pdb
495	Q10P	L2	PZA	Q	Q10	10	P	1	MDR	DM	hydrophilic	hydrophilic	neutral	non-polar	polar	non-polar	6.02	-1.771	-0.631	6.78299	-2.963	-0.11	95	95	-1.214	9	9	0	0	strand	-0.933333333333333	8.14	0.0211297973264338	156.233890214797	156.233722233267	156.382472756358	1333.51093453962	38	-2	0	-2	6	2	4	0	-8	2	-6	-4	0	2	0	-0.448581560283688	-0.163049095607235	0.247051260571537	-0.505200341005968	-0.0287958115183246	1	-1	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.229	-1.201	9:9	147/150	Q	5.05135310548255	2.49562215648785e-55	0.322395320006857	15.6681961306855	87.7376148601903	314.979076956589	2.19377524680641	1.27822918710216e-207	206.893391269988	83.6783303393677	330.782028899935	5.90060424845557e-292	lineage2	dr_mutations_pyrazinamide	PRO	SAMEA2534067,ERS457469	ERR551610_ERR551611	lineage2.2.1	uz	Nukus	pnca_p.gln10pro	A	B	GLN	QA10	pnca_complex.pdb
496	Q10P	L4	PZA	Q	Q10	10	P	1	Pre-XDR	DM	hydrophilic	hydrophilic	neutral	non-polar	polar	non-polar	6.02	-1.771	-0.631	6.78299	-2.963	-0.11	95	95	-1.214	9	9	0	0	strand	-0.933333333333333	8.14	0.0211297973264338	156.233890214797	156.233722233267	156.382472756358	1333.51093453962	38	-2	0	-2	6	2	4	0	-8	2	-6	-4	0	2	0	-0.448581560283688	-0.163049095607235	0.247051260571537	-0.505200341005968	-0.0287958115183246	1	-1	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.229	-1.201	9:9	147/150	Q	5.05135310548255	2.49562215648785e-55	0.322395320006857	15.6681961306855	87.7376148601903	314.979076956589	2.19377524680641	1.27822918710216e-207	206.893391269988	83.6783303393677	330.782028899935	5.90060424845557e-292	lineage4	dr_mutations_pyrazinamide	PRO	ERR760736	ERR760736	lineage4.1.2.1	ar	Argentina	pnca_p.gln10pro	A	B	GLN	QA10	pnca_complex.pdb
497	Q10P	L4	PZA	Q	Q10	10	P	1	Pre-XDR	DM	hydrophilic	hydrophilic	neutral	non-polar	polar	non-polar	6.02	-1.771	-0.631	6.78299	-2.963	-0.11	95	95	-1.214	9	9	0	0	strand	-0.933333333333333	8.14	0.0211297973264338	156.233890214797	156.233722233267	156.382472756358	1333.51093453962	38	-2	0	-2	6	2	4	0	-8	2	-6	-4	0	2	0	-0.448581560283688	-0.163049095607235	0.247051260571537	-0.505200341005968	-0.0287958115183246	1	-1	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.229	-1.201	9:9	147/150	Q	5.05135310548255	2.49562215648785e-55	0.322395320006857	15.6681961306855	87.7376148601903	314.979076956589	2.19377524680641	1.27822918710216e-207	206.893391269988	83.6783303393677	330.782028899935	5.90060424845557e-292	lineage4	dr_mutations_pyrazinamide	PRO	ERR757188	ERR757188	lineage4.1.2.1	ar	Argentina	pnca_p.gln10pro	A	B	GLN	QA10	pnca_complex.pdb
498	Q10P	L4	PZA	Q	Q10	10	P	1	Pre-XDR	DM	hydrophilic	hydrophilic	neutral	non-polar	polar	non-polar	6.02	-1.771	-0.631	6.78299	-2.963	-0.11	95	95	-1.214	9	9	0	0	strand	-0.933333333333333	8.14	0.0211297973264338	156.233890214797	156.233722233267	156.382472756358	1333.51093453962	38	-2	0	-2	6	2	4	0	-8	2	-6	-4	0	2	0	-0.448581560283688	-0.163049095607235	0.247051260571537	-0.505200341005968	-0.0287958115183246	1	-1	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.229	-1.201	9:9	147/150	Q	5.05135310548255	2.49562215648785e-55	0.322395320006857	15.6681961306855	87.7376148601903	314.979076956589	2.19377524680641	1.27822918710216e-207	206.893391269988	83.6783303393677	330.782028899935	5.90060424845557e-292	lineage4	dr_mutations_pyrazinamide	PRO	ERR760902	ERR760902	lineage4.1.2.1	ar	Argentina	pnca_p.gln10pro	A	B	GLN	QA10	pnca_complex.pdb
499	Q10P	L4	PZA	Q	Q10	10	P	1	Pre-XDR	DM	hydrophilic	hydrophilic	neutral	non-polar	polar	non-polar	6.02	-1.771	-0.631	6.78299	-2.963	-0.11	95	95	-1.214	9	9	0	0	strand	-0.933333333333333	8.14	0.0211297973264338	156.233890214797	156.233722233267	156.382472756358	1333.51093453962	38	-2	0	-2	6	2	4	0	-8	2	-6	-4	0	2	0	-0.448581560283688	-0.163049095607235	0.247051260571537	-0.505200341005968	-0.0287958115183246	1	-1	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.229	-1.201	9:9	147/150	Q	5.05135310548255	2.49562215648785e-55	0.322395320006857	15.6681961306855	87.7376148601903	314.979076956589	2.19377524680641	1.27822918710216e-207	206.893391269988	83.6783303393677	330.782028899935	5.90060424845557e-292	lineage4	dr_mutations_pyrazinamide	PRO	ERR760916	ERR760916	lineage4.1.2.1	ar	Argentina	pnca_p.gln10pro	A	B	GLN	QA10	pnca_complex.pdb
500	Q10P	L4	PZA	Q	Q10	10	P	NA	MDR	DM	hydrophilic	hydrophilic	neutral	non-polar	polar	non-polar	6.02	-1.771	-0.631	6.78299	-2.963	-0.11	95	95	-1.214	9	9	0	0	strand	-0.933333333333333	8.14	0.0211297973264338	156.233890214797	156.233722233267	156.382472756358	1333.51093453962	38	-2	0	-2	6	2	4	0	-8	2	-6	-4	0	2	0	-0.448581560283688	-0.163049095607235	0.247051260571537	-0.505200341005968	-0.0287958115183246	1	-1	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.229	-1.201	9:9	147/150	Q	5.05135310548255	2.49562215648785e-55	0.322395320006857	15.6681961306855	87.7376148601903	314.979076956589	2.19377524680641	1.27822918710216e-207	206.893391269988	83.6783303393677	330.782028899935	5.90060424845557e-292	lineage4	dr_mutations_pyrazinamide	PRO	ERR1023472	ERR1023472	lineage4.3.2.1			pnca_p.gln10pro	A	B	GLN	QA10	pnca_complex.pdb
501	Q10P	L2	PZA	Q	Q10	10	P	1	MDR	DM	hydrophilic	hydrophilic	neutral	non-polar	polar	non-polar	6.02	-1.771	-0.631	6.78299	-2.963	-0.11	95	95	-1.214	9	9	0	0	strand	-0.933333333333333	8.14	0.0211297973264338	156.233890214797	156.233722233267	156.382472756358	1333.51093453962	38	-2	0	-2	6	2	4	0	-8	2	-6	-4	0	2	0	-0.448581560283688	-0.163049095607235	0.247051260571537	-0.505200341005968	-0.0287958115183246	1	-1	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.229	-1.201	9:9	147/150	Q	5.05135310548255	2.49562215648785e-55	0.322395320006857	15.6681961306855	87.7376148601903	314.979076956589	2.19377524680641	1.27822918710216e-207	206.893391269988	83.6783303393677	330.782028899935	5.90060424845557e-292	lineage2	dr_mutations_pyrazinamide	PRO	ERS458053,SAMEA2534651,ERR552441	ERR552441	lineage2.2.1	uz	Nukus	pnca_p.gln10pro	A	B	GLN	QA10	pnca_complex.pdb
502	Q10P	L4	PZA	Q	Q10	10	P	1	Pre-XDR	DM	hydrophilic	hydrophilic	neutral	non-polar	polar	non-polar	6.02	-1.771	-0.631	6.78299	-2.963	-0.11	95	95	-1.214	9	9	0	0	strand	-0.933333333333333	8.14	0.0211297973264338	156.233890214797	156.233722233267	156.382472756358	1333.51093453962	38	-2	0	-2	6	2	4	0	-8	2	-6	-4	0	2	0	-0.448581560283688	-0.163049095607235	0.247051260571537	-0.505200341005968	-0.0287958115183246	1	-1	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.229	-1.201	9:9	147/150	Q	5.05135310548255	2.49562215648785e-55	0.322395320006857	15.6681961306855	87.7376148601903	314.979076956589	2.19377524680641	1.27822918710216e-207	206.893391269988	83.6783303393677	330.782028899935	5.90060424845557e-292	lineage4	dr_mutations_pyrazinamide	PRO	ERR760846	ERR760846	lineage4.1.2.1	ar	Argentina	pnca_p.gln10pro	A	B	GLN	QA10	pnca_complex.pdb
503	Q10P	L2	PZA	Q	Q10	10	P	1	MDR	DM	hydrophilic	hydrophilic	neutral	non-polar	polar	non-polar	6.02	-1.771	-0.631	6.78299	-2.963	-0.11	95	95	-1.214	9	9	0	0	strand	-0.933333333333333	8.14	0.0211297973264338	156.233890214797	156.233722233267	156.382472756358	1333.51093453962	38	-2	0	-2	6	2	4	0	-8	2	-6	-4	0	2	0	-0.448581560283688	-0.163049095607235	0.247051260571537	-0.505200341005968	-0.0287958115183246	1	-1	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.229	-1.201	9:9	147/150	Q	5.05135310548255	2.49562215648785e-55	0.322395320006857	15.6681961306855	87.7376148601903	314.979076956589	2.19377524680641	1.27822918710216e-207	206.893391269988	83.6783303393677	330.782028899935	5.90060424845557e-292	lineage2	dr_mutations_pyrazinamide	PRO	ERS457589,SAMEA2534187	ERR551780_ERR551781	lineage2.2.1	uz	Nukus	pnca_p.gln10pro	A	B	GLN	QA10	pnca_complex.pdb
504	Q10P	L4	PZA	Q	Q10	10	P	1	Pre-XDR	DM	hydrophilic	hydrophilic	neutral	non-polar	polar	non-polar	6.02	-1.771	-0.631	6.78299	-2.963	-0.11	95	95	-1.214	9	9	0	0	strand	-0.933333333333333	8.14	0.0211297973264338	156.233890214797	156.233722233267	156.382472756358	1333.51093453962	38	-2	0	-2	6	2	4	0	-8	2	-6	-4	0	2	0	-0.448581560283688	-0.163049095607235	0.247051260571537	-0.505200341005968	-0.0287958115183246	1	-1	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.229	-1.201	9:9	147/150	Q	5.05135310548255	2.49562215648785e-55	0.322395320006857	15.6681961306855	87.7376148601903	314.979076956589	2.19377524680641	1.27822918710216e-207	206.893391269988	83.6783303393677	330.782028899935	5.90060424845557e-292	lineage4	dr_mutations_pyrazinamide	PRO	ERR757178	ERR757178	lineage4.1.2.1	ar	Argentina	pnca_p.gln10pro	A	B	GLN	QA10	pnca_complex.pdb
505	Q10P	L4	PZA	Q	Q10	10	P	1	Pre-XDR	DM	hydrophilic	hydrophilic	neutral	non-polar	polar	non-polar	6.02	-1.771	-0.631	6.78299	-2.963	-0.11	95	95	-1.214	9	9	0	0	strand	-0.933333333333333	8.14	0.0211297973264338	156.233890214797	156.233722233267	156.382472756358	1333.51093453962	38	-2	0	-2	6	2	4	0	-8	2	-6	-4	0	2	0	-0.448581560283688	-0.163049095607235	0.247051260571537	-0.505200341005968	-0.0287958115183246	1	-1	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.229	-1.201	9:9	147/150	Q	5.05135310548255	2.49562215648785e-55	0.322395320006857	15.6681961306855	87.7376148601903	314.979076956589	2.19377524680641	1.27822918710216e-207	206.893391269988	83.6783303393677	330.782028899935	5.90060424845557e-292	lineage4	dr_mutations_pyrazinamide	PRO	ERR760739	ERR760739	lineage4.1.2.1	ar	Argentina	pnca_p.gln10pro	A	B	GLN	QA10	pnca_complex.pdb
506	Q10P	L2	PZA	Q	Q10	10	P	1	MDR	DM	hydrophilic	hydrophilic	neutral	non-polar	polar	non-polar	6.02	-1.771	-0.631	6.78299	-2.963	-0.11	95	95	-1.214	9	9	0	0	strand	-0.933333333333333	8.14	0.0211297973264338	156.233890214797	156.233722233267	156.382472756358	1333.51093453962	38	-2	0	-2	6	2	4	0	-8	2	-6	-4	0	2	0	-0.448581560283688	-0.163049095607235	0.247051260571537	-0.505200341005968	-0.0287958115183246	1	-1	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.229	-1.201	9:9	147/150	Q	5.05135310548255	2.49562215648785e-55	0.322395320006857	15.6681961306855	87.7376148601903	314.979076956589	2.19377524680641	1.27822918710216e-207	206.893391269988	83.6783303393677	330.782028899935	5.90060424845557e-292	lineage2	dr_mutations_pyrazinamide	PRO	ERS457017,SAMEA2533615	ERR550988_ERR550989_ERR550990	lineage2.2.1	uz	Nukus	pnca_p.gln10pro	A	B	GLN	QA10	pnca_complex.pdb
507	Q10P	L4	PZA	Q	Q10	10	P	1	Pre-XDR	DM	hydrophilic	hydrophilic	neutral	non-polar	polar	non-polar	6.02	-1.771	-0.631	6.78299	-2.963	-0.11	95	95	-1.214	9	9	0	0	strand	-0.933333333333333	8.14	0.0211297973264338	156.233890214797	156.233722233267	156.382472756358	1333.51093453962	38	-2	0	-2	6	2	4	0	-8	2	-6	-4	0	2	0	-0.448581560283688	-0.163049095607235	0.247051260571537	-0.505200341005968	-0.0287958115183246	1	-1	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.229	-1.201	9:9	147/150	Q	5.05135310548255	2.49562215648785e-55	0.322395320006857	15.6681961306855	87.7376148601903	314.979076956589	2.19377524680641	1.27822918710216e-207	206.893391269988	83.6783303393677	330.782028899935	5.90060424845557e-292	lineage4	dr_mutations_pyrazinamide	PRO	ERR760836	ERR760836	lineage4.1.2.1	ar	Argentina	pnca_p.gln10pro	A	B	GLN	QA10	pnca_complex.pdb
508	Q10P	L4	PZA	Q	Q10	10	P	NA	Pre-XDR	DM	hydrophilic	hydrophilic	neutral	non-polar	polar	non-polar	6.02	-1.771	-0.631	6.78299	-2.963	-0.11	95	95	-1.214	9	9	0	0	strand	-0.933333333333333	8.14	0.0211297973264338	156.233890214797	156.233722233267	156.382472756358	1333.51093453962	38	-2	0	-2	6	2	4	0	-8	2	-6	-4	0	2	0	-0.448581560283688	-0.163049095607235	0.247051260571537	-0.505200341005968	-0.0287958115183246	1	-1	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.229	-1.201	9:9	147/150	Q	5.05135310548255	2.49562215648785e-55	0.322395320006857	15.6681961306855	87.7376148601903	314.979076956589	2.19377524680641	1.27822918710216e-207	206.893391269988	83.6783303393677	330.782028899935	5.90060424845557e-292	lineage4	dr_mutations_pyrazinamide	PRO	ERR1035005	ERR1035005	lineage4.4.1.1	za	South Africa	pnca_p.gln10pro	A	B	GLN	QA10	pnca_complex.pdb
509	Q10P	L2	PZA	Q	Q10	10	P	1	MDR	DM	hydrophilic	hydrophilic	neutral	non-polar	polar	non-polar	6.02	-1.771	-0.631	6.78299	-2.963	-0.11	95	95	-1.214	9	9	0	0	strand	-0.933333333333333	8.14	0.0211297973264338	156.233890214797	156.233722233267	156.382472756358	1333.51093453962	38	-2	0	-2	6	2	4	0	-8	2	-6	-4	0	2	0	-0.448581560283688	-0.163049095607235	0.247051260571537	-0.505200341005968	-0.0287958115183246	1	-1	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.229	-1.201	9:9	147/150	Q	5.05135310548255	2.49562215648785e-55	0.322395320006857	15.6681961306855	87.7376148601903	314.979076956589	2.19377524680641	1.27822918710216e-207	206.893391269988	83.6783303393677	330.782028899935	5.90060424845557e-292	lineage2	dr_mutations_pyrazinamide	PRO	ERS458603	ERR553189_ERR553188_ERR553190	lineage2.2.1	uz	Nukus	pnca_p.gln10pro	A	B	GLN	QA10	pnca_complex.pdb
510	Q10P	L2	PZA	Q	Q10	10	P	1	MDR	DM	hydrophilic	hydrophilic	neutral	non-polar	polar	non-polar	6.02	-1.771	-0.631	6.78299	-2.963	-0.11	95	95	-1.214	9	9	0	0	strand	-0.933333333333333	8.14	0.0211297973264338	156.233890214797	156.233722233267	156.382472756358	1333.51093453962	38	-2	0	-2	6	2	4	0	-8	2	-6	-4	0	2	0	-0.448581560283688	-0.163049095607235	0.247051260571537	-0.505200341005968	-0.0287958115183246	1	-1	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.229	-1.201	9:9	147/150	Q	5.05135310548255	2.49562215648785e-55	0.322395320006857	15.6681961306855	87.7376148601903	314.979076956589	2.19377524680641	1.27822918710216e-207	206.893391269988	83.6783303393677	330.782028899935	5.90060424845557e-292	lineage2	dr_mutations_pyrazinamide	PRO	ERS457844	ERR552144_ERR552143_ERR552142	lineage2.2.1	uz	Nukus	pnca_p.gln10pro	A	B	GLN	QA10	pnca_complex.pdb
511	Q10P	L4	PZA	Q	Q10	10	P	1	XDR	DM	hydrophilic	hydrophilic	neutral	non-polar	polar	non-polar	6.02	-1.771	-0.631	6.78299	-2.963	-0.11	95	95	-1.214	9	9	0	0	strand	-0.933333333333333	8.14	0.0211297973264338	156.233890214797	156.233722233267	156.382472756358	1333.51093453962	38	-2	0	-2	6	2	4	0	-8	2	-6	-4	0	2	0	-0.448581560283688	-0.163049095607235	0.247051260571537	-0.505200341005968	-0.0287958115183246	1	-1	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.229	-1.201	9:9	147/150	Q	5.05135310548255	2.49562215648785e-55	0.322395320006857	15.6681961306855	87.7376148601903	314.979076956589	2.19377524680641	1.27822918710216e-207	206.893391269988	83.6783303393677	330.782028899935	5.90060424845557e-292	lineage4	dr_mutations_pyrazinamide	PRO	ERR760896	ERR760896	lineage4.1.2.1	ar	Argentina	pnca_p.gln10pro	A	B	GLN	QA10	pnca_complex.pdb
512	Q10P	L2	PZA	Q	Q10	10	P	NA	Pre-MDR	DM	hydrophilic	hydrophilic	neutral	non-polar	polar	non-polar	6.02	-1.771	-0.631	6.78299	-2.963	-0.11	95	95	-1.214	9	9	0	0	strand	-0.933333333333333	8.14	0.0211297973264338	156.233890214797	156.233722233267	156.382472756358	1333.51093453962	38	-2	0	-2	6	2	4	0	-8	2	-6	-4	0	2	0	-0.448581560283688	-0.163049095607235	0.247051260571537	-0.505200341005968	-0.0287958115183246	1	-1	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.229	-1.201	9:9	147/150	Q	5.05135310548255	2.49562215648785e-55	0.322395320006857	15.6681961306855	87.7376148601903	314.979076956589	2.19377524680641	1.27822918710216e-207	206.893391269988	83.6783303393677	330.782028899935	5.90060424845557e-292	lineage2	dr_mutations_pyrazinamide	PRO	0932P-sc-2011-09-07T13:19:25Z-1276485,ERR067638	ERR067638	lineage2.2.1	ru	Russia	pnca_p.gln10pro	A	B	GLN	QA10	pnca_complex.pdb
513	Q10P	L4	PZA	Q	Q10	10	P	1	Pre-XDR	DM	hydrophilic	hydrophilic	neutral	non-polar	polar	non-polar	6.02	-1.771	-0.631	6.78299	-2.963	-0.11	95	95	-1.214	9	9	0	0	strand	-0.933333333333333	8.14	0.0211297973264338	156.233890214797	156.233722233267	156.382472756358	1333.51093453962	38	-2	0	-2	6	2	4	0	-8	2	-6	-4	0	2	0	-0.448581560283688	-0.163049095607235	0.247051260571537	-0.505200341005968	-0.0287958115183246	1	-1	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.229	-1.201	9:9	147/150	Q	5.05135310548255	2.49562215648785e-55	0.322395320006857	15.6681961306855	87.7376148601903	314.979076956589	2.19377524680641	1.27822918710216e-207	206.893391269988	83.6783303393677	330.782028899935	5.90060424845557e-292	lineage4	dr_mutations_pyrazinamide	PRO	ERR760764	ERR760764	lineage4.1.2.1	ar	Argentina	pnca_p.gln10pro	A	B	GLN	QA10	pnca_complex.pdb
514	Q10P	L2	PZA	Q	Q10	10	P	NA	Pre-XDR	DM	hydrophilic	hydrophilic	neutral	non-polar	polar	non-polar	6.02	-1.771	-0.631	6.78299	-2.963	-0.11	95	95	-1.214	9	9	0	0	strand	-0.933333333333333	8.14	0.0211297973264338	156.233890214797	156.233722233267	156.382472756358	1333.51093453962	38	-2	0	-2	6	2	4	0	-8	2	-6	-4	0	2	0	-0.448581560283688	-0.163049095607235	0.247051260571537	-0.505200341005968	-0.0287958115183246	1	-1	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.229	-1.201	9:9	147/150	Q	5.05135310548255	2.49562215648785e-55	0.322395320006857	15.6681961306855	87.7376148601903	314.979076956589	2.19377524680641	1.27822918710216e-207	206.893391269988	83.6783303393677	330.782028899935	5.90060424845557e-292	lineage2	dr_mutations_pyrazinamide	PRO	SRS797090	SRR1723595_SRR1723596	lineage2.2.1	cn	China:Jiangxi	pnca_p.gln10pro	A	B	GLN	QA10	pnca_complex.pdb
515	Q10P	L2	PZA	Q	Q10	10	P	1	Pre-XDR	DM	hydrophilic	hydrophilic	neutral	non-polar	polar	non-polar	6.02	-1.771	-0.631	6.78299	-2.963	-0.11	95	95	-1.214	9	9	0	0	strand	-0.933333333333333	8.14	0.0211297973264338	156.233890214797	156.233722233267	156.382472756358	1333.51093453962	38	-2	0	-2	6	2	4	0	-8	2	-6	-4	0	2	0	-0.448581560283688	-0.163049095607235	0.247051260571537	-0.505200341005968	-0.0287958115183246	1	-1	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.229	-1.201	9:9	147/150	Q	5.05135310548255	2.49562215648785e-55	0.322395320006857	15.6681961306855	87.7376148601903	314.979076956589	2.19377524680641	1.27822918710216e-207	206.893391269988	83.6783303393677	330.782028899935	5.90060424845557e-292	lineage2	dr_mutations_pyrazinamide	PRO	ERS457881	ERR552198_ERR552199_ERR552197_ERR552200	lineage2.2.1	uz	Nukus	pnca_p.gln10pro	A	B	GLN	QA10	pnca_complex.pdb
516	Q10P	L4	PZA	Q	Q10	10	P	1	Pre-XDR	DM	hydrophilic	hydrophilic	neutral	non-polar	polar	non-polar	6.02	-1.771	-0.631	6.78299	-2.963	-0.11	95	95	-1.214	9	9	0	0	strand	-0.933333333333333	8.14	0.0211297973264338	156.233890214797	156.233722233267	156.382472756358	1333.51093453962	38	-2	0	-2	6	2	4	0	-8	2	-6	-4	0	2	0	-0.448581560283688	-0.163049095607235	0.247051260571537	-0.505200341005968	-0.0287958115183246	1	-1	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.229	-1.201	9:9	147/150	Q	5.05135310548255	2.49562215648785e-55	0.322395320006857	15.6681961306855	87.7376148601903	314.979076956589	2.19377524680641	1.27822918710216e-207	206.893391269988	83.6783303393677	330.782028899935	5.90060424845557e-292	lineage4	dr_mutations_pyrazinamide	PRO	ERR757175	ERR757175	lineage4.1.2.1	ar	Argentina	pnca_p.gln10pro	A	B	GLN	QA10	pnca_complex.pdb
517	Q10P	L4	PZA	Q	Q10	10	P	1	Pre-XDR	DM	hydrophilic	hydrophilic	neutral	non-polar	polar	non-polar	6.02	-1.771	-0.631	6.78299	-2.963	-0.11	95	95	-1.214	9	9	0	0	strand	-0.933333333333333	8.14	0.0211297973264338	156.233890214797	156.233722233267	156.382472756358	1333.51093453962	38	-2	0	-2	6	2	4	0	-8	2	-6	-4	0	2	0	-0.448581560283688	-0.163049095607235	0.247051260571537	-0.505200341005968	-0.0287958115183246	1	-1	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.229	-1.201	9:9	147/150	Q	5.05135310548255	2.49562215648785e-55	0.322395320006857	15.6681961306855	87.7376148601903	314.979076956589	2.19377524680641	1.27822918710216e-207	206.893391269988	83.6783303393677	330.782028899935	5.90060424845557e-292	lineage4	dr_mutations_pyrazinamide	PRO	ERR760864	ERR760864	lineage4.1.2.1	ar	Argentina	pnca_p.gln10pro	A	B	GLN	QA10	pnca_complex.pdb
518	Q10P	L2	PZA	Q	Q10	10	P	0	Pre-XDR	DM	hydrophilic	hydrophilic	neutral	non-polar	polar	non-polar	6.02	-1.771	-0.631	6.78299	-2.963	-0.11	95	95	-1.214	9	9	0	0	strand	-0.933333333333333	8.14	0.0211297973264338	156.233890214797	156.233722233267	156.382472756358	1333.51093453962	38	-2	0	-2	6	2	4	0	-8	2	-6	-4	0	2	0	-0.448581560283688	-0.163049095607235	0.247051260571537	-0.505200341005968	-0.0287958115183246	1	-1	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.229	-1.201	9:9	147/150	Q	5.05135310548255	2.49562215648785e-55	0.322395320006857	15.6681961306855	87.7376148601903	314.979076956589	2.19377524680641	1.27822918710216e-207	206.893391269988	83.6783303393677	330.782028899935	5.90060424845557e-292	lineage2	dr_mutations_pyrazinamide	PRO	ERS458645	ERR553247_ERR553246	lineage2.2.1	uz	Nukus	pnca_p.gln10pro	A	B	GLN	QA10	pnca_complex.pdb
519	Q10P	L4	PZA	Q	Q10	10	P	1	Pre-XDR	DM	hydrophilic	hydrophilic	neutral	non-polar	polar	non-polar	6.02	-1.771	-0.631	6.78299	-2.963	-0.11	95	95	-1.214	9	9	0	0	strand	-0.933333333333333	8.14	0.0211297973264338	156.233890214797	156.233722233267	156.382472756358	1333.51093453962	38	-2	0	-2	6	2	4	0	-8	2	-6	-4	0	2	0	-0.448581560283688	-0.163049095607235	0.247051260571537	-0.505200341005968	-0.0287958115183246	1	-1	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.229	-1.201	9:9	147/150	Q	5.05135310548255	2.49562215648785e-55	0.322395320006857	15.6681961306855	87.7376148601903	314.979076956589	2.19377524680641	1.27822918710216e-207	206.893391269988	83.6783303393677	330.782028899935	5.90060424845557e-292	lineage4	dr_mutations_pyrazinamide	PRO	ERR760747	ERR760747	lineage4.1.2.1	ar	Argentina	pnca_p.gln10pro	A	B	GLN	QA10	pnca_complex.pdb
520	Q10P	L2	PZA	Q	Q10	10	P	0	MDR	DM	hydrophilic	hydrophilic	neutral	non-polar	polar	non-polar	6.02	-1.771	-0.631	6.78299	-2.963	-0.11	95	95	-1.214	9	9	0	0	strand	-0.933333333333333	8.14	0.0211297973264338	156.233890214797	156.233722233267	156.382472756358	1333.51093453962	38	-2	0	-2	6	2	4	0	-8	2	-6	-4	0	2	0	-0.448581560283688	-0.163049095607235	0.247051260571537	-0.505200341005968	-0.0287958115183246	1	-1	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.229	-1.201	9:9	147/150	Q	5.05135310548255	2.49562215648785e-55	0.322395320006857	15.6681961306855	87.7376148601903	314.979076956589	2.19377524680641	1.27822918710216e-207	206.893391269988	83.6783303393677	330.782028899935	5.90060424845557e-292	lineage2	dr_mutations_pyrazinamide	PRO	ERS458206	ERR552661_ERR552660	lineage2.2.1	uz	Nukus	pnca_p.gln10pro	A	B	GLN	QA10	pnca_complex.pdb
521	Q10P	L4	PZA	Q	Q10	10	P	1	Pre-XDR	DM	hydrophilic	hydrophilic	neutral	non-polar	polar	non-polar	6.02	-1.771	-0.631	6.78299	-2.963	-0.11	95	95	-1.214	9	9	0	0	strand	-0.933333333333333	8.14	0.0211297973264338	156.233890214797	156.233722233267	156.382472756358	1333.51093453962	38	-2	0	-2	6	2	4	0	-8	2	-6	-4	0	2	0	-0.448581560283688	-0.163049095607235	0.247051260571537	-0.505200341005968	-0.0287958115183246	1	-1	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.229	-1.201	9:9	147/150	Q	5.05135310548255	2.49562215648785e-55	0.322395320006857	15.6681961306855	87.7376148601903	314.979076956589	2.19377524680641	1.27822918710216e-207	206.893391269988	83.6783303393677	330.782028899935	5.90060424845557e-292	lineage4	dr_mutations_pyrazinamide	PRO	ERR757183	ERR757183	lineage4.1.2.1	ar	Argentina	pnca_p.gln10pro	A	B	GLN	QA10	pnca_complex.pdb
522	Q10P	L4	PZA	Q	Q10	10	P	1	Pre-XDR	DM	hydrophilic	hydrophilic	neutral	non-polar	polar	non-polar	6.02	-1.771	-0.631	6.78299	-2.963	-0.11	95	95	-1.214	9	9	0	0	strand	-0.933333333333333	8.14	0.0211297973264338	156.233890214797	156.233722233267	156.382472756358	1333.51093453962	38	-2	0	-2	6	2	4	0	-8	2	-6	-4	0	2	0	-0.448581560283688	-0.163049095607235	0.247051260571537	-0.505200341005968	-0.0287958115183246	1	-1	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.229	-1.201	9:9	147/150	Q	5.05135310548255	2.49562215648785e-55	0.322395320006857	15.6681961306855	87.7376148601903	314.979076956589	2.19377524680641	1.27822918710216e-207	206.893391269988	83.6783303393677	330.782028899935	5.90060424845557e-292	lineage4	dr_mutations_pyrazinamide	PRO	ERR760831	ERR760831	lineage4.1.2.1	ar	Argentina	pnca_p.gln10pro	A	B	GLN	QA10	pnca_complex.pdb
523	Q10P	L2	PZA	Q	Q10	10	P	NA	MDR	DM	hydrophilic	hydrophilic	neutral	non-polar	polar	non-polar	6.02	-1.771	-0.631	6.78299	-2.963	-0.11	95	95	-1.214	9	9	0	0	strand	-0.933333333333333	8.14	0.0211297973264338	156.233890214797	156.233722233267	156.382472756358	1333.51093453962	38	-2	0	-2	6	2	4	0	-8	2	-6	-4	0	2	0	-0.448581560283688	-0.163049095607235	0.247051260571537	-0.505200341005968	-0.0287958115183246	1	-1	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.229	-1.201	9:9	147/150	Q	5.05135310548255	2.49562215648785e-55	0.322395320006857	15.6681961306855	87.7376148601903	314.979076956589	2.19377524680641	1.27822918710216e-207	206.893391269988	83.6783303393677	330.782028899935	5.90060424845557e-292	lineage2	dr_mutations_pyrazinamide	PRO	BGI_SH068,SRR671811	SRR671811	lineage2.2.1	cn	China	pnca_p.gln10pro	A	B	GLN	QA10	pnca_complex.pdb
524	Q10P	L2	PZA	Q	Q10	10	P	1	MDR	DM	hydrophilic	hydrophilic	neutral	non-polar	polar	non-polar	6.02	-1.771	-0.631	6.78299	-2.963	-0.11	95	95	-1.214	9	9	0	0	strand	-0.933333333333333	8.14	0.0211297973264338	156.233890214797	156.233722233267	156.382472756358	1333.51093453962	38	-2	0	-2	6	2	4	0	-8	2	-6	-4	0	2	0	-0.448581560283688	-0.163049095607235	0.247051260571537	-0.505200341005968	-0.0287958115183246	1	-1	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.229	-1.201	9:9	147/150	Q	5.05135310548255	2.49562215648785e-55	0.322395320006857	15.6681961306855	87.7376148601903	314.979076956589	2.19377524680641	1.27822918710216e-207	206.893391269988	83.6783303393677	330.782028899935	5.90060424845557e-292	lineage2	dr_mutations_pyrazinamide	PRO	ERS457920,SAMEA2534518	ERR552257_ERR552258	lineage2.2.1	uz	Nukus	pnca_p.gln10pro	A	B	GLN	QA10	pnca_complex.pdb
525	Q10P	L4	PZA	Q	Q10	10	P	1	Pre-XDR	DM	hydrophilic	hydrophilic	neutral	non-polar	polar	non-polar	6.02	-1.771	-0.631	6.78299	-2.963	-0.11	95	95	-1.214	9	9	0	0	strand	-0.933333333333333	8.14	0.0211297973264338	156.233890214797	156.233722233267	156.382472756358	1333.51093453962	38	-2	0	-2	6	2	4	0	-8	2	-6	-4	0	2	0	-0.448581560283688	-0.163049095607235	0.247051260571537	-0.505200341005968	-0.0287958115183246	1	-1	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.229	-1.201	9:9	147/150	Q	5.05135310548255	2.49562215648785e-55	0.322395320006857	15.6681961306855	87.7376148601903	314.979076956589	2.19377524680641	1.27822918710216e-207	206.893391269988	83.6783303393677	330.782028899935	5.90060424845557e-292	lineage4	dr_mutations_pyrazinamide	PRO	ERR757167	ERR757167	lineage4.1.2.1	ar	Argentina	pnca_p.gln10pro	A	B	GLN	QA10	pnca_complex.pdb
526	Q10P	L4	PZA	Q	Q10	10	P	1	Pre-XDR	DM	hydrophilic	hydrophilic	neutral	non-polar	polar	non-polar	6.02	-1.771	-0.631	6.78299	-2.963	-0.11	95	95	-1.214	9	9	0	0	strand	-0.933333333333333	8.14	0.0211297973264338	156.233890214797	156.233722233267	156.382472756358	1333.51093453962	38	-2	0	-2	6	2	4	0	-8	2	-6	-4	0	2	0	-0.448581560283688	-0.163049095607235	0.247051260571537	-0.505200341005968	-0.0287958115183246	1	-1	Destabilising	Destabilising	Destabilising	Destabilising	Destabilising	effect	-1.229	-1.201	9:9	147/150	Q	5.05135310548255	2.49562215648785e-55	0.322395320006857	15.6681961306855	87.7376148601903	314.979076956589	2.19377524680641	1.27822918710216e-207	206.893391269988	83.6783303393677	330.782028899935	5.90060424845557e-292	lineage4	dr_mutations_pyrazinamide	PRO	ERR760909	ERR760909	lineage4.1.2.1	ar	Argentina	pnca_p.gln10pro	A	B	GLN	QA10	pnca_complex.pdb

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