1 | mutationinformation | lineage_labels | ligand_id | wild_type | wild_pos | position | mutant_type | pyrazinamide | drtype | mutation_info_labels | wt_prop_water | mut_prop_water | wt_prop_polarity | mut_prop_polarity | wt_calcprop | mut_calcprop | ligand_distance | ligand_affinity_change | duet_stability_change | ddg_foldx | deepddg | ddg_dynamut2 | snap2_score | snap2_accuracy_pc | consurf_score | consurf_colour | consurf_colour_rev | asa | rsa | ss_class | kd_values | rd_values | af | or_mychisq | or_logistic | or_fisher | est_chisq | contacts | electro_rr | electro_mm | electro_sm | electro_ss | disulfide_rr | disulfide_mm | disulfide_sm | disulfide_ss | hbonds_rr | hbonds_mm | hbonds_sm | hbonds_ss | partcov_rr | partcov_mm | partcov_sm | partcov_ss | vdwclashes_rr | vdwclashes_mm | vdwclashes_sm | vdwclashes_ss | volumetric_rr | volumetric_mm | volumetric_sm | volumetric_ss | affinity_scaled | duet_scaled | foldx_scaled | deepddg_scaled | ddg_dynamut2_scaled | snap2_scaled | consurf_scaled | ligand_outcome | duet_outcome | foldx_outcome | deepddg_outcome | ddg_dynamut2_outcome | snap2_outcome | consurf_ci_upper | consurf_ci_lower | consurf_ci_colour | consurf_msa_data | consurf_aa_variety | beta_logistic | pval_logistic | se_logistic | zval_logistic | ci_low_logistic | ci_hi_logistic | log10_or_mychisq | pval_fisher | neglog_pval_fisher | ci_low_fisher | ci_hi_fisher | pval_chisq | lineage | mutation_info | mut_3upper | seq_offset4pdb | id | sample | sublineage | country_code | geographic_source | mutation | chain | ss | wt_3upper | wild_chain_pos | pdb_file |
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2 | M1I | L4 | PZA | M | M1 | 1 | I | NA | Pre-XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 23.978 | -0.294 | -0.347 | -0.0549615 | -0.407 | -0.79 | 7 | 53 | -1.048 | 9 | 9 | 88 | 0.392857142857143 | loop | 0.633333333333333 | 4.12 | 0.0001437401178668 | 1.2119588062211 | 4.59700131334276e-05 | 0 | 1.01056822389159e-25 | 6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -3 | 0 | -3 | -3 | 0 | 0 | 0 | 0 | -0.0744680851063829 | -0.0896640826873385 | -0.0105670806736907 | -0.0693947144075021 | -0.206806282722513 | 0.0736842105263158 | -0.86326194398682 | Destabilising | Destabilising | Stabilising | Destabilising | Destabilising | effect | -1.178 | -0.993 | 9:9 | 21/150 | V:M | -9.98752126245056 | 0.942832958100734 | 139.277183325397 | -0.0717096729269464 | NA | 144471.706314837 | 0.0834878586628579 | 1 | 0 | 0 | 25.8386585962163 | 0.999999999999746 | lineage4 | other_mutations_pyrazinamide | ILE | 0 | SAMN07236323,SRR5709866 | SRR5709866 | lineage4.4.2 | th | Thailand | pnca_p.met1ile | A | - | MET | MA1 | pnca_complex.pdb |
3 | M1I | L2 | PZA | M | M1 | 1 | I | 0 | MDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 23.978 | -0.294 | -0.347 | -0.0549615 | -0.407 | -0.79 | 7 | 53 | -1.048 | 9 | 9 | 88 | 0.392857142857143 | loop | 0.633333333333333 | 4.12 | 0.0001437401178668 | 1.2119588062211 | 4.59700131334276e-05 | 0 | 1.01056822389159e-25 | 6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -3 | 0 | -3 | -3 | 0 | 0 | 0 | 0 | -0.0744680851063829 | -0.0896640826873385 | -0.0105670806736907 | -0.0693947144075021 | -0.206806282722513 | 0.0736842105263158 | -0.86326194398682 | Destabilising | Destabilising | Stabilising | Destabilising | Destabilising | effect | -1.178 | -0.993 | 9:9 | 21/150 | V:M | -9.98752126245056 | 0.942832958100734 | 139.277183325397 | -0.0717096729269464 | NA | 144471.706314837 | 0.0834878586628579 | 1 | 0 | 0 | 25.8386585962163 | 0.999999999999746 | lineage2 | other_mutations_pyrazinamide | ILE | 0 | SAMEA2533466,ERS456868 | ERR550784_ERR550785 | lineage2.2.1 | uz | Nukus | pnca_p.met1ile | A | - | MET | MA1 | pnca_complex.pdb |
4 | M1I | L2 | PZA | M | M1 | 1 | I | 0 | MDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 23.978 | -0.294 | -0.347 | -0.0549615 | -0.407 | -0.79 | 7 | 53 | -1.048 | 9 | 9 | 88 | 0.392857142857143 | loop | 0.633333333333333 | 4.12 | 0.0001437401178668 | 1.2119588062211 | 4.59700131334276e-05 | 0 | 1.01056822389159e-25 | 6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -3 | 0 | -3 | -3 | 0 | 0 | 0 | 0 | -0.0744680851063829 | -0.0896640826873385 | -0.0105670806736907 | -0.0693947144075021 | -0.206806282722513 | 0.0736842105263158 | -0.86326194398682 | Destabilising | Destabilising | Stabilising | Destabilising | Destabilising | effect | -1.178 | -0.993 | 9:9 | 21/150 | V:M | -9.98752126245056 | 0.942832958100734 | 139.277183325397 | -0.0717096729269464 | NA | 144471.706314837 | 0.0834878586628579 | 1 | 0 | 0 | 25.8386585962163 | 0.999999999999746 | lineage2 | other_mutations_pyrazinamide | ILE | 0 | ERS456961,SAMEA2533559 | ERR550914_ERR550915 | lineage2.2.1 | uz | Nukus | pnca_p.met1ile | A | - | MET | MA1 | pnca_complex.pdb |
5 | M1K | L3 | PZA | M | M1 | 1 | K | 0 | MDR | OM | hydrophobic | hydrophobic | non-polar | basic | non-polar | pos | 23.978 | 0.215 | 0.296 | 0.0794895 | -1.017 | -0.34 | 70 | 85 | -1.048 | 9 | 9 | 88 | 0.392857142857143 | loop | 0.633333333333333 | 4.12 | 7.18700589334483e-05 | 2.42412778478352 | 0.0001249735077034 | 0 | 1.03410070803344e-29 | -6 | -2 | 0 | 0 | -18 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | -1 | 0 | -1 | -1 | 0 | 0 | 0 | 0 | 0.0964125560538116 | 0.251700680272109 | 0.00289518061757443 | -0.173401534526854 | -0.0890052356020942 | 0.736842105263158 | -0.86326194398682 | Stabilising | Stabilising | Destabilising | Destabilising | Destabilising | effect | -1.178 | -0.993 | 9:9 | 21/150 | V:M | -8.98740878149642 | 0.940032862253633 | 119.468044435492 | -0.0752285585987748 | NA | 4692673.51081395 | 0.384555509373631 | 1 | 0 | 0 | 188.544222231268 | 0.999999999999997 | lineage3 | other_mutations_pyrazinamide | LYS | 0 | ERR2510542 | ERR2510542 | lineage3 | pk | Pakistan | pnca_p.met1lys | A | - | MET | MA1 | pnca_complex.pdb |
6 | M1R | L2 | PZA | M | M1 | 1 | R | NA | MDR | OM | hydrophobic | hydrophilic | non-polar | basic | non-polar | pos | 23.978 | -0.16 | 0.694 | -0.00977971 | -0.78 | 1.21 | 44 | 71 | -1.048 | 9 | 9 | 88 | 0.392857142857143 | loop | 0.633333333333333 | 4.12 | NA | NA | NA | NA | NA | -14 | 0 | 0 | 0 | -20 | 0 | 0 | 0 | 0 | -2 | 0 | -2 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | -1 | 1 | 0 | 0 | -2 | -2 | -0.0405268490374873 | 0.590136054421769 | -0.00188027955087288 | -0.132992327365729 | 0.679775280898876 | 0.463157894736842 | -0.86326194398682 | Destabilising | Stabilising | Stabilising | Destabilising | Stabilising | effect | -1.178 | -0.993 | 9:9 | 21/150 | V:M | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | lineage2 | other_mutations_pyrazinamide | ARG | 0 | SRR5073787 | SRR5073787 | lineage2.2.1 | vn | Vietnam | pnca_p.met1arg | A | - | MET | MA1 | pnca_complex.pdb |
7 | M1R | L4 | PZA | M | M1 | 1 | R | NA | MDR | OM | hydrophobic | hydrophilic | non-polar | basic | non-polar | pos | 23.978 | -0.16 | 0.694 | -0.00977971 | -0.78 | 1.21 | 44 | 71 | -1.048 | 9 | 9 | 88 | 0.392857142857143 | loop | 0.633333333333333 | 4.12 | NA | NA | NA | NA | NA | -14 | 0 | 0 | 0 | -20 | 0 | 0 | 0 | 0 | -2 | 0 | -2 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | -1 | 1 | 0 | 0 | -2 | -2 | -0.0405268490374873 | 0.590136054421769 | -0.00188027955087288 | -0.132992327365729 | 0.679775280898876 | 0.463157894736842 | -0.86326194398682 | Destabilising | Stabilising | Stabilising | Destabilising | Stabilising | effect | -1.178 | -0.993 | 9:9 | 21/150 | V:M | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | lineage4 | other_mutations_pyrazinamide | ARG | 0 | ERR2707157 | ERR2707157 | lineage4.3.2 | cd | Democratic Republic of Congo | pnca_p.met1arg | A | - | MET | MA1 | pnca_complex.pdb |
8 | M1T | L4 | PZA | M | M1 | 1 | T | NA | MDR | DM | hydrophobic | hydrophobic | non-polar | neutral | non-polar | polar | 23.978 | 0.344 | 0.109 | 0.867771 | -1.096 | 0.51 | 52 | 75 | -1.048 | 9 | 9 | 88 | 0.392857142857143 | loop | 0.633333333333333 | 4.12 | 0.0007187005893344 | 97.3828619670747 | 1395803.74890195 | Inf | 42.8452490786805 | 10 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 0.154260089686099 | 0.0926870748299319 | 0.031606108727482 | -0.186871270247229 | 0.286516853932584 | 0.547368421052632 | -0.86326194398682 | Stabilising | Stabilising | Destabilising | Destabilising | Stabilising | effect | -1.178 | -0.993 | 9:9 | 21/150 | V:M | 14.1489809714062 | 0.890414731995374 | 102.692976014008 | 0.137779442378573 | 507.712885368923 | NA | 1.98848253379833 | 2.1018584548314e-08 | 7.67739653395739 | 10.9022485555592 | Inf | 5.92457926729285e-11 | lineage4 | dr_mutations_pyrazinamide | THR | 0 | ERR2515926 | ERR2515926 | lineage4.8 | za | South Africa | pnca_p.met1thr | A | - | MET | MA1 | pnca_complex.pdb |
9 | M1T | L2 | PZA | M | M1 | 1 | T | 1 | Pre-XDR | DM | hydrophobic | hydrophobic | non-polar | neutral | non-polar | polar | 23.978 | 0.344 | 0.109 | 0.867771 | -1.096 | 0.51 | 52 | 75 | -1.048 | 9 | 9 | 88 | 0.392857142857143 | loop | 0.633333333333333 | 4.12 | 0.0007187005893344 | 97.3828619670747 | 1395803.74890195 | Inf | 42.8452490786805 | 10 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 0.154260089686099 | 0.0926870748299319 | 0.031606108727482 | -0.186871270247229 | 0.286516853932584 | 0.547368421052632 | -0.86326194398682 | Stabilising | Stabilising | Destabilising | Destabilising | Stabilising | effect | -1.178 | -0.993 | 9:9 | 21/150 | V:M | 14.1489809714062 | 0.890414731995374 | 102.692976014008 | 0.137779442378573 | 507.712885368923 | NA | 1.98848253379833 | 2.1018584548314e-08 | 7.67739653395739 | 10.9022485555592 | Inf | 5.92457926729285e-11 | lineage2 | dr_mutations_pyrazinamide | THR | 0 | MDR_4152 | SRR6824577 | lineage2.2.1 | cn | China: Pingding County, Yangquan City, Shanxi Province | pnca_p.met1thr | A | - | MET | MA1 | pnca_complex.pdb |
10 | M1T | L2 | PZA | M | M1 | 1 | T | 1 | Pre-XDR | DM | hydrophobic | hydrophobic | non-polar | neutral | non-polar | polar | 23.978 | 0.344 | 0.109 | 0.867771 | -1.096 | 0.51 | 52 | 75 | -1.048 | 9 | 9 | 88 | 0.392857142857143 | loop | 0.633333333333333 | 4.12 | 0.0007187005893344 | 97.3828619670747 | 1395803.74890195 | Inf | 42.8452490786805 | 10 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 0.154260089686099 | 0.0926870748299319 | 0.031606108727482 | -0.186871270247229 | 0.286516853932584 | 0.547368421052632 | -0.86326194398682 | Stabilising | Stabilising | Destabilising | Destabilising | Stabilising | effect | -1.178 | -0.993 | 9:9 | 21/150 | V:M | 14.1489809714062 | 0.890414731995374 | 102.692976014008 | 0.137779442378573 | 507.712885368923 | NA | 1.98848253379833 | 2.1018584548314e-08 | 7.67739653395739 | 10.9022485555592 | Inf | 5.92457926729285e-11 | lineage2 | dr_mutations_pyrazinamide | THR | 0 | MDR_4129 | SRR6824467 | lineage2.2.1 | cn | China: Pingding County, Yangquan City, Shanxi Province | pnca_p.met1thr | A | - | MET | MA1 | pnca_complex.pdb |
11 | M1T | L2 | PZA | M | M1 | 1 | T | NA | XDR | DM | hydrophobic | hydrophobic | non-polar | neutral | non-polar | polar | 23.978 | 0.344 | 0.109 | 0.867771 | -1.096 | 0.51 | 52 | 75 | -1.048 | 9 | 9 | 88 | 0.392857142857143 | loop | 0.633333333333333 | 4.12 | 0.0007187005893344 | 97.3828619670747 | 1395803.74890195 | Inf | 42.8452490786805 | 10 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 0.154260089686099 | 0.0926870748299319 | 0.031606108727482 | -0.186871270247229 | 0.286516853932584 | 0.547368421052632 | -0.86326194398682 | Stabilising | Stabilising | Destabilising | Destabilising | Stabilising | effect | -1.178 | -0.993 | 9:9 | 21/150 | V:M | 14.1489809714062 | 0.890414731995374 | 102.692976014008 | 0.137779442378573 | 507.712885368923 | NA | 1.98848253379833 | 2.1018584548314e-08 | 7.67739653395739 | 10.9022485555592 | Inf | 5.92457926729285e-11 | lineage2 | dr_mutations_pyrazinamide | THR | 0 | SAMN02419548 | SRR1183962_SRR1180936_SRR1159760_SRR1159954 | lineage2.2.1 | by | Belarus | pnca_p.met1thr | A | - | MET | MA1 | pnca_complex.pdb |
12 | M1T | L4 | PZA | M | M1 | 1 | T | NA | XDR | DM | hydrophobic | hydrophobic | non-polar | neutral | non-polar | polar | 23.978 | 0.344 | 0.109 | 0.867771 | -1.096 | 0.51 | 52 | 75 | -1.048 | 9 | 9 | 88 | 0.392857142857143 | loop | 0.633333333333333 | 4.12 | 0.0007187005893344 | 97.3828619670747 | 1395803.74890195 | Inf | 42.8452490786805 | 10 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 0.154260089686099 | 0.0926870748299319 | 0.031606108727482 | -0.186871270247229 | 0.286516853932584 | 0.547368421052632 | -0.86326194398682 | Stabilising | Stabilising | Destabilising | Destabilising | Stabilising | effect | -1.178 | -0.993 | 9:9 | 21/150 | V:M | 14.1489809714062 | 0.890414731995374 | 102.692976014008 | 0.137779442378573 | 507.712885368923 | NA | 1.98848253379833 | 2.1018584548314e-08 | 7.67739653395739 | 10.9022485555592 | Inf | 5.92457926729285e-11 | lineage4 | dr_mutations_pyrazinamide | THR | 0 | ERR1034850 | ERR1034850 | lineage4.3.4.2 | pt | Portugal | pnca_p.met1thr | A | - | MET | MA1 | pnca_complex.pdb |
13 | M1T | L4 | PZA | M | M1 | 1 | T | NA | XDR | DM | hydrophobic | hydrophobic | non-polar | neutral | non-polar | polar | 23.978 | 0.344 | 0.109 | 0.867771 | -1.096 | 0.51 | 52 | 75 | -1.048 | 9 | 9 | 88 | 0.392857142857143 | loop | 0.633333333333333 | 4.12 | 0.0007187005893344 | 97.3828619670747 | 1395803.74890195 | Inf | 42.8452490786805 | 10 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 0.154260089686099 | 0.0926870748299319 | 0.031606108727482 | -0.186871270247229 | 0.286516853932584 | 0.547368421052632 | -0.86326194398682 | Stabilising | Stabilising | Destabilising | Destabilising | Stabilising | effect | -1.178 | -0.993 | 9:9 | 21/150 | V:M | 14.1489809714062 | 0.890414731995374 | 102.692976014008 | 0.137779442378573 | 507.712885368923 | NA | 1.98848253379833 | 2.1018584548314e-08 | 7.67739653395739 | 10.9022485555592 | Inf | 5.92457926729285e-11 | lineage4 | dr_mutations_pyrazinamide | THR | 0 | ERR275203 | ERR275203 | lineage4.3.4.2 | pt | Portugal | pnca_p.met1thr | A | - | MET | MA1 | pnca_complex.pdb |
14 | M1T | L4 | PZA | M | M1 | 1 | T | NA | XDR | DM | hydrophobic | hydrophobic | non-polar | neutral | non-polar | polar | 23.978 | 0.344 | 0.109 | 0.867771 | -1.096 | 0.51 | 52 | 75 | -1.048 | 9 | 9 | 88 | 0.392857142857143 | loop | 0.633333333333333 | 4.12 | 0.0007187005893344 | 97.3828619670747 | 1395803.74890195 | Inf | 42.8452490786805 | 10 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 0.154260089686099 | 0.0926870748299319 | 0.031606108727482 | -0.186871270247229 | 0.286516853932584 | 0.547368421052632 | -0.86326194398682 | Stabilising | Stabilising | Destabilising | Destabilising | Stabilising | effect | -1.178 | -0.993 | 9:9 | 21/150 | V:M | 14.1489809714062 | 0.890414731995374 | 102.692976014008 | 0.137779442378573 | 507.712885368923 | NA | 1.98848253379833 | 2.1018584548314e-08 | 7.67739653395739 | 10.9022485555592 | Inf | 5.92457926729285e-11 | lineage4 | dr_mutations_pyrazinamide | THR | 0 | ERR1034847 | ERR1034847 | lineage4.3.4.2 | pt | Portugal | pnca_p.met1thr | A | - | MET | MA1 | pnca_complex.pdb |
15 | M1T | L2 | PZA | M | M1 | 1 | T | 1 | Pre-XDR | DM | hydrophobic | hydrophobic | non-polar | neutral | non-polar | polar | 23.978 | 0.344 | 0.109 | 0.867771 | -1.096 | 0.51 | 52 | 75 | -1.048 | 9 | 9 | 88 | 0.392857142857143 | loop | 0.633333333333333 | 4.12 | 0.0007187005893344 | 97.3828619670747 | 1395803.74890195 | Inf | 42.8452490786805 | 10 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 0.154260089686099 | 0.0926870748299319 | 0.031606108727482 | -0.186871270247229 | 0.286516853932584 | 0.547368421052632 | -0.86326194398682 | Stabilising | Stabilising | Destabilising | Destabilising | Stabilising | effect | -1.178 | -0.993 | 9:9 | 21/150 | V:M | 14.1489809714062 | 0.890414731995374 | 102.692976014008 | 0.137779442378573 | 507.712885368923 | NA | 1.98848253379833 | 2.1018584548314e-08 | 7.67739653395739 | 10.9022485555592 | Inf | 5.92457926729285e-11 | lineage2 | dr_mutations_pyrazinamide | THR | 0 | MDR_4113 | SRR6824464 | lineage2.2.1 | cn | China: Pingding County, Yangquan City, Shanxi Province | pnca_p.met1thr | A | - | MET | MA1 | pnca_complex.pdb |
16 | M1T | L4 | PZA | M | M1 | 1 | T | 1 | XDR | DM | hydrophobic | hydrophobic | non-polar | neutral | non-polar | polar | 23.978 | 0.344 | 0.109 | 0.867771 | -1.096 | 0.51 | 52 | 75 | -1.048 | 9 | 9 | 88 | 0.392857142857143 | loop | 0.633333333333333 | 4.12 | 0.0007187005893344 | 97.3828619670747 | 1395803.74890195 | Inf | 42.8452490786805 | 10 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 0.154260089686099 | 0.0926870748299319 | 0.031606108727482 | -0.186871270247229 | 0.286516853932584 | 0.547368421052632 | -0.86326194398682 | Stabilising | Stabilising | Destabilising | Destabilising | Stabilising | effect | -1.178 | -0.993 | 9:9 | 21/150 | V:M | 14.1489809714062 | 0.890414731995374 | 102.692976014008 | 0.137779442378573 | 507.712885368923 | NA | 1.98848253379833 | 2.1018584548314e-08 | 7.67739653395739 | 10.9022485555592 | Inf | 5.92457926729285e-11 | lineage4 | dr_mutations_pyrazinamide | THR | 0 | ERR1034908 | ERR1034908 | lineage4.3.4.2 | pt | Portugal | pnca_p.met1thr | A | - | MET | MA1 | pnca_complex.pdb |
17 | M1T | L4 | PZA | M | M1 | 1 | T | 1 | XDR | DM | hydrophobic | hydrophobic | non-polar | neutral | non-polar | polar | 23.978 | 0.344 | 0.109 | 0.867771 | -1.096 | 0.51 | 52 | 75 | -1.048 | 9 | 9 | 88 | 0.392857142857143 | loop | 0.633333333333333 | 4.12 | 0.0007187005893344 | 97.3828619670747 | 1395803.74890195 | Inf | 42.8452490786805 | 10 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 0.154260089686099 | 0.0926870748299319 | 0.031606108727482 | -0.186871270247229 | 0.286516853932584 | 0.547368421052632 | -0.86326194398682 | Stabilising | Stabilising | Destabilising | Destabilising | Stabilising | effect | -1.178 | -0.993 | 9:9 | 21/150 | V:M | 14.1489809714062 | 0.890414731995374 | 102.692976014008 | 0.137779442378573 | 507.712885368923 | NA | 1.98848253379833 | 2.1018584548314e-08 | 7.67739653395739 | 10.9022485555592 | Inf | 5.92457926729285e-11 | lineage4 | dr_mutations_pyrazinamide | THR | 0 | ERR2864241 | ERR2864241 | lineage4.3.4.2 | pt | Portugal | pnca_p.met1thr | A | - | MET | MA1 | pnca_complex.pdb |
18 | M1T | L4 | PZA | M | M1 | 1 | T | 1 | XDR | DM | hydrophobic | hydrophobic | non-polar | neutral | non-polar | polar | 23.978 | 0.344 | 0.109 | 0.867771 | -1.096 | 0.51 | 52 | 75 | -1.048 | 9 | 9 | 88 | 0.392857142857143 | loop | 0.633333333333333 | 4.12 | 0.0007187005893344 | 97.3828619670747 | 1395803.74890195 | Inf | 42.8452490786805 | 10 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 0.154260089686099 | 0.0926870748299319 | 0.031606108727482 | -0.186871270247229 | 0.286516853932584 | 0.547368421052632 | -0.86326194398682 | Stabilising | Stabilising | Destabilising | Destabilising | Stabilising | effect | -1.178 | -0.993 | 9:9 | 21/150 | V:M | 14.1489809714062 | 0.890414731995374 | 102.692976014008 | 0.137779442378573 | 507.712885368923 | NA | 1.98848253379833 | 2.1018584548314e-08 | 7.67739653395739 | 10.9022485555592 | Inf | 5.92457926729285e-11 | lineage4 | dr_mutations_pyrazinamide | THR | 0 | ERR1035222 | ERR1035222 | lineage4.3.4.2 | pt | Portugal | pnca_p.met1thr | A | - | MET | MA1 | pnca_complex.pdb |
19 | M1T | L1 | PZA | M | M1 | 1 | T | NA | Pre-XDR | DM | hydrophobic | hydrophobic | non-polar | neutral | non-polar | polar | 23.978 | 0.344 | 0.109 | 0.867771 | -1.096 | 0.51 | 52 | 75 | -1.048 | 9 | 9 | 88 | 0.392857142857143 | loop | 0.633333333333333 | 4.12 | 0.0007187005893344 | 97.3828619670747 | 1395803.74890195 | Inf | 42.8452490786805 | 10 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 0.154260089686099 | 0.0926870748299319 | 0.031606108727482 | -0.186871270247229 | 0.286516853932584 | 0.547368421052632 | -0.86326194398682 | Stabilising | Stabilising | Destabilising | Destabilising | Stabilising | effect | -1.178 | -0.993 | 9:9 | 21/150 | V:M | 14.1489809714062 | 0.890414731995374 | 102.692976014008 | 0.137779442378573 | 507.712885368923 | NA | 1.98848253379833 | 2.1018584548314e-08 | 7.67739653395739 | 10.9022485555592 | Inf | 5.92457926729285e-11 | lineage1 | dr_mutations_pyrazinamide | THR | 0 | SRR5818699 | SRR5818699 | lineage1.1.2 | dj | Djibouti | pnca_p.met1thr | A | - | MET | MA1 | pnca_complex.pdb |
20 | M1T | L2 | PZA | M | M1 | 1 | T | NA | Pre-XDR | DM | hydrophobic | hydrophobic | non-polar | neutral | non-polar | polar | 23.978 | 0.344 | 0.109 | 0.867771 | -1.096 | 0.51 | 52 | 75 | -1.048 | 9 | 9 | 88 | 0.392857142857143 | loop | 0.633333333333333 | 4.12 | 0.0007187005893344 | 97.3828619670747 | 1395803.74890195 | Inf | 42.8452490786805 | 10 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 0.154260089686099 | 0.0926870748299319 | 0.031606108727482 | -0.186871270247229 | 0.286516853932584 | 0.547368421052632 | -0.86326194398682 | Stabilising | Stabilising | Destabilising | Destabilising | Stabilising | effect | -1.178 | -0.993 | 9:9 | 21/150 | V:M | 14.1489809714062 | 0.890414731995374 | 102.692976014008 | 0.137779442378573 | 507.712885368923 | NA | 1.98848253379833 | 2.1018584548314e-08 | 7.67739653395739 | 10.9022485555592 | Inf | 5.92457926729285e-11 | lineage2 | dr_mutations_pyrazinamide | THR | 0 | SRS797056 | SRR1723559 | lineage2.2.1 | cn | China:Shanxi | pnca_p.met1thr | A | - | MET | MA1 | pnca_complex.pdb |
21 | M1T | L4 | PZA | M | M1 | 1 | T | 1 | XDR | DM | hydrophobic | hydrophobic | non-polar | neutral | non-polar | polar | 23.978 | 0.344 | 0.109 | 0.867771 | -1.096 | 0.51 | 52 | 75 | -1.048 | 9 | 9 | 88 | 0.392857142857143 | loop | 0.633333333333333 | 4.12 | 0.0007187005893344 | 97.3828619670747 | 1395803.74890195 | Inf | 42.8452490786805 | 10 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 0.154260089686099 | 0.0926870748299319 | 0.031606108727482 | -0.186871270247229 | 0.286516853932584 | 0.547368421052632 | -0.86326194398682 | Stabilising | Stabilising | Destabilising | Destabilising | Stabilising | effect | -1.178 | -0.993 | 9:9 | 21/150 | V:M | 14.1489809714062 | 0.890414731995374 | 102.692976014008 | 0.137779442378573 | 507.712885368923 | NA | 1.98848253379833 | 2.1018584548314e-08 | 7.67739653395739 | 10.9022485555592 | Inf | 5.92457926729285e-11 | lineage4 | dr_mutations_pyrazinamide | THR | 0 | ERR1035226 | ERR1035226 | lineage4.3.4.2 | pt | Portugal | pnca_p.met1thr | A | - | MET | MA1 | pnca_complex.pdb |
22 | M1T | L2 | PZA | M | M1 | 1 | T | NA | Pre-XDR | DM | hydrophobic | hydrophobic | non-polar | neutral | non-polar | polar | 23.978 | 0.344 | 0.109 | 0.867771 | -1.096 | 0.51 | 52 | 75 | -1.048 | 9 | 9 | 88 | 0.392857142857143 | loop | 0.633333333333333 | 4.12 | 0.0007187005893344 | 97.3828619670747 | 1395803.74890195 | Inf | 42.8452490786805 | 10 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 0.154260089686099 | 0.0926870748299319 | 0.031606108727482 | -0.186871270247229 | 0.286516853932584 | 0.547368421052632 | -0.86326194398682 | Stabilising | Stabilising | Destabilising | Destabilising | Stabilising | effect | -1.178 | -0.993 | 9:9 | 21/150 | V:M | 14.1489809714062 | 0.890414731995374 | 102.692976014008 | 0.137779442378573 | 507.712885368923 | NA | 1.98848253379833 | 2.1018584548314e-08 | 7.67739653395739 | 10.9022485555592 | Inf | 5.92457926729285e-11 | lineage2 | dr_mutations_pyrazinamide | THR | 0 | SRR5709907,SAMN07236409 | SRR5709907 | lineage2.2.1 | th | Thailand | pnca_p.met1thr | A | - | MET | MA1 | pnca_complex.pdb |
23 | M1T | L2 | PZA | M | M1 | 1 | T | NA | Pre-XDR | DM | hydrophobic | hydrophobic | non-polar | neutral | non-polar | polar | 23.978 | 0.344 | 0.109 | 0.867771 | -1.096 | 0.51 | 52 | 75 | -1.048 | 9 | 9 | 88 | 0.392857142857143 | loop | 0.633333333333333 | 4.12 | 0.0007187005893344 | 97.3828619670747 | 1395803.74890195 | Inf | 42.8452490786805 | 10 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 0.154260089686099 | 0.0926870748299319 | 0.031606108727482 | -0.186871270247229 | 0.286516853932584 | 0.547368421052632 | -0.86326194398682 | Stabilising | Stabilising | Destabilising | Destabilising | Stabilising | effect | -1.178 | -0.993 | 9:9 | 21/150 | V:M | 14.1489809714062 | 0.890414731995374 | 102.692976014008 | 0.137779442378573 | 507.712885368923 | NA | 1.98848253379833 | 2.1018584548314e-08 | 7.67739653395739 | 10.9022485555592 | Inf | 5.92457926729285e-11 | lineage2 | dr_mutations_pyrazinamide | THR | 0 | SRS797053 | SRR1723556 | lineage2.2.1 | cn | China:Shanxi | pnca_p.met1thr | A | - | MET | MA1 | pnca_complex.pdb |
24 | M1T | L3 | PZA | M | M1 | 1 | T | 1 | Pre-XDR | DM | hydrophobic | hydrophobic | non-polar | neutral | non-polar | polar | 23.978 | 0.344 | 0.109 | 0.867771 | -1.096 | 0.51 | 52 | 75 | -1.048 | 9 | 9 | 88 | 0.392857142857143 | loop | 0.633333333333333 | 4.12 | 0.0007187005893344 | 97.3828619670747 | 1395803.74890195 | Inf | 42.8452490786805 | 10 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 0.154260089686099 | 0.0926870748299319 | 0.031606108727482 | -0.186871270247229 | 0.286516853932584 | 0.547368421052632 | -0.86326194398682 | Stabilising | Stabilising | Destabilising | Destabilising | Stabilising | effect | -1.178 | -0.993 | 9:9 | 21/150 | V:M | 14.1489809714062 | 0.890414731995374 | 102.692976014008 | 0.137779442378573 | 507.712885368923 | NA | 1.98848253379833 | 2.1018584548314e-08 | 7.67739653395739 | 10.9022485555592 | Inf | 5.92457926729285e-11 | lineage3 | dr_mutations_pyrazinamide | THR | 0 | ERR2510282 | ERR2510282 | lineage3 | pk | Pakistan | pnca_p.met1thr | A | - | MET | MA1 | pnca_complex.pdb |
25 | M1T | L2 | PZA | M | M1 | 1 | T | NA | XDR | DM | hydrophobic | hydrophobic | non-polar | neutral | non-polar | polar | 23.978 | 0.344 | 0.109 | 0.867771 | -1.096 | 0.51 | 52 | 75 | -1.048 | 9 | 9 | 88 | 0.392857142857143 | loop | 0.633333333333333 | 4.12 | 0.0007187005893344 | 97.3828619670747 | 1395803.74890195 | Inf | 42.8452490786805 | 10 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 0.154260089686099 | 0.0926870748299319 | 0.031606108727482 | -0.186871270247229 | 0.286516853932584 | 0.547368421052632 | -0.86326194398682 | Stabilising | Stabilising | Destabilising | Destabilising | Stabilising | effect | -1.178 | -0.993 | 9:9 | 21/150 | V:M | 14.1489809714062 | 0.890414731995374 | 102.692976014008 | 0.137779442378573 | 507.712885368923 | NA | 1.98848253379833 | 2.1018584548314e-08 | 7.67739653395739 | 10.9022485555592 | Inf | 5.92457926729285e-11 | lineage2 | dr_mutations_pyrazinamide | THR | 0 | SAMN02419662 | SRR1172219_SRR1169121_SRR1163325_SRR1163145 | lineage2.2.1 | by | Belarus | pnca_p.met1thr | A | - | MET | MA1 | pnca_complex.pdb |
26 | M1T | L2 | PZA | M | M1 | 1 | T | NA | MDR | DM | hydrophobic | hydrophobic | non-polar | neutral | non-polar | polar | 23.978 | 0.344 | 0.109 | 0.867771 | -1.096 | 0.51 | 52 | 75 | -1.048 | 9 | 9 | 88 | 0.392857142857143 | loop | 0.633333333333333 | 4.12 | 0.0007187005893344 | 97.3828619670747 | 1395803.74890195 | Inf | 42.8452490786805 | 10 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 0.154260089686099 | 0.0926870748299319 | 0.031606108727482 | -0.186871270247229 | 0.286516853932584 | 0.547368421052632 | -0.86326194398682 | Stabilising | Stabilising | Destabilising | Destabilising | Stabilising | effect | -1.178 | -0.993 | 9:9 | 21/150 | V:M | 14.1489809714062 | 0.890414731995374 | 102.692976014008 | 0.137779442378573 | 507.712885368923 | NA | 1.98848253379833 | 2.1018584548314e-08 | 7.67739653395739 | 10.9022485555592 | Inf | 5.92457926729285e-11 | lineage2 | dr_mutations_pyrazinamide | THR | 0 | ETB0073 | SRR6257010 | lineage2.2.1 | ru | Russia:Tatarstan | pnca_p.met1thr | A | - | MET | MA1 | pnca_complex.pdb |
27 | M1T | L4 | PZA | M | M1 | 1 | T | NA | XDR | DM | hydrophobic | hydrophobic | non-polar | neutral | non-polar | polar | 23.978 | 0.344 | 0.109 | 0.867771 | -1.096 | 0.51 | 52 | 75 | -1.048 | 9 | 9 | 88 | 0.392857142857143 | loop | 0.633333333333333 | 4.12 | 0.0007187005893344 | 97.3828619670747 | 1395803.74890195 | Inf | 42.8452490786805 | 10 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 0.154260089686099 | 0.0926870748299319 | 0.031606108727482 | -0.186871270247229 | 0.286516853932584 | 0.547368421052632 | -0.86326194398682 | Stabilising | Stabilising | Destabilising | Destabilising | Stabilising | effect | -1.178 | -0.993 | 9:9 | 21/150 | V:M | 14.1489809714062 | 0.890414731995374 | 102.692976014008 | 0.137779442378573 | 507.712885368923 | NA | 1.98848253379833 | 2.1018584548314e-08 | 7.67739653395739 | 10.9022485555592 | Inf | 5.92457926729285e-11 | lineage4 | dr_mutations_pyrazinamide | THR | 0 | ERR1034885 | ERR1034885 | lineage4.3.4.2 | pt | Portugal | pnca_p.met1thr | A | - | MET | MA1 | pnca_complex.pdb |
28 | M1T | L2 | PZA | M | M1 | 1 | T | 1 | Pre-XDR | DM | hydrophobic | hydrophobic | non-polar | neutral | non-polar | polar | 23.978 | 0.344 | 0.109 | 0.867771 | -1.096 | 0.51 | 52 | 75 | -1.048 | 9 | 9 | 88 | 0.392857142857143 | loop | 0.633333333333333 | 4.12 | 0.0007187005893344 | 97.3828619670747 | 1395803.74890195 | Inf | 42.8452490786805 | 10 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 0.154260089686099 | 0.0926870748299319 | 0.031606108727482 | -0.186871270247229 | 0.286516853932584 | 0.547368421052632 | -0.86326194398682 | Stabilising | Stabilising | Destabilising | Destabilising | Stabilising | effect | -1.178 | -0.993 | 9:9 | 21/150 | V:M | 14.1489809714062 | 0.890414731995374 | 102.692976014008 | 0.137779442378573 | 507.712885368923 | NA | 1.98848253379833 | 2.1018584548314e-08 | 7.67739653395739 | 10.9022485555592 | Inf | 5.92457926729285e-11 | lineage2 | dr_mutations_pyrazinamide | THR | 0 | ERR2510666 | ERR2510666 | lineage2.2.1 | it | Italy | pnca_p.met1thr | A | - | MET | MA1 | pnca_complex.pdb |
29 | M1T | L4 | PZA | M | M1 | 1 | T | 1 | XDR | DM | hydrophobic | hydrophobic | non-polar | neutral | non-polar | polar | 23.978 | 0.344 | 0.109 | 0.867771 | -1.096 | 0.51 | 52 | 75 | -1.048 | 9 | 9 | 88 | 0.392857142857143 | loop | 0.633333333333333 | 4.12 | 0.0007187005893344 | 97.3828619670747 | 1395803.74890195 | Inf | 42.8452490786805 | 10 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 0.154260089686099 | 0.0926870748299319 | 0.031606108727482 | -0.186871270247229 | 0.286516853932584 | 0.547368421052632 | -0.86326194398682 | Stabilising | Stabilising | Destabilising | Destabilising | Stabilising | effect | -1.178 | -0.993 | 9:9 | 21/150 | V:M | 14.1489809714062 | 0.890414731995374 | 102.692976014008 | 0.137779442378573 | 507.712885368923 | NA | 1.98848253379833 | 2.1018584548314e-08 | 7.67739653395739 | 10.9022485555592 | Inf | 5.92457926729285e-11 | lineage4 | dr_mutations_pyrazinamide | THR | 0 | ERR1035215 | ERR1035215 | lineage4.3.4.2 | pt | Portugal | pnca_p.met1thr | A | - | MET | MA1 | pnca_complex.pdb |
30 | M1T | L2 | PZA | M | M1 | 1 | T | NA | Pre-XDR | DM | hydrophobic | hydrophobic | non-polar | neutral | non-polar | polar | 23.978 | 0.344 | 0.109 | 0.867771 | -1.096 | 0.51 | 52 | 75 | -1.048 | 9 | 9 | 88 | 0.392857142857143 | loop | 0.633333333333333 | 4.12 | 0.0007187005893344 | 97.3828619670747 | 1395803.74890195 | Inf | 42.8452490786805 | 10 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 0.154260089686099 | 0.0926870748299319 | 0.031606108727482 | -0.186871270247229 | 0.286516853932584 | 0.547368421052632 | -0.86326194398682 | Stabilising | Stabilising | Destabilising | Destabilising | Stabilising | effect | -1.178 | -0.993 | 9:9 | 21/150 | V:M | 14.1489809714062 | 0.890414731995374 | 102.692976014008 | 0.137779442378573 | 507.712885368923 | NA | 1.98848253379833 | 2.1018584548314e-08 | 7.67739653395739 | 10.9022485555592 | Inf | 5.92457926729285e-11 | lineage2 | dr_mutations_pyrazinamide | THR | 0 | SRR5710022,SAMN07236279 | SRR5710022 | lineage2.1 | th | Thailand | pnca_p.met1thr | A | - | MET | MA1 | pnca_complex.pdb |
31 | M1T | L2 | PZA | M | M1 | 1 | T | NA | Pre-XDR | DM | hydrophobic | hydrophobic | non-polar | neutral | non-polar | polar | 23.978 | 0.344 | 0.109 | 0.867771 | -1.096 | 0.51 | 52 | 75 | -1.048 | 9 | 9 | 88 | 0.392857142857143 | loop | 0.633333333333333 | 4.12 | 0.0007187005893344 | 97.3828619670747 | 1395803.74890195 | Inf | 42.8452490786805 | 10 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 0.154260089686099 | 0.0926870748299319 | 0.031606108727482 | -0.186871270247229 | 0.286516853932584 | 0.547368421052632 | -0.86326194398682 | Stabilising | Stabilising | Destabilising | Destabilising | Stabilising | effect | -1.178 | -0.993 | 9:9 | 21/150 | V:M | 14.1489809714062 | 0.890414731995374 | 102.692976014008 | 0.137779442378573 | 507.712885368923 | NA | 1.98848253379833 | 2.1018584548314e-08 | 7.67739653395739 | 10.9022485555592 | Inf | 5.92457926729285e-11 | lineage2 | dr_mutations_pyrazinamide | THR | 0 | SRS797054 | SRR1723557 | lineage2.2.1 | cn | China:Shanxi | pnca_p.met1thr | A | - | MET | MA1 | pnca_complex.pdb |
32 | M1T | L2 | PZA | M | M1 | 1 | T | NA | Pre-XDR | DM | hydrophobic | hydrophobic | non-polar | neutral | non-polar | polar | 23.978 | 0.344 | 0.109 | 0.867771 | -1.096 | 0.51 | 52 | 75 | -1.048 | 9 | 9 | 88 | 0.392857142857143 | loop | 0.633333333333333 | 4.12 | 0.0007187005893344 | 97.3828619670747 | 1395803.74890195 | Inf | 42.8452490786805 | 10 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 0.154260089686099 | 0.0926870748299319 | 0.031606108727482 | -0.186871270247229 | 0.286516853932584 | 0.547368421052632 | -0.86326194398682 | Stabilising | Stabilising | Destabilising | Destabilising | Stabilising | effect | -1.178 | -0.993 | 9:9 | 21/150 | V:M | 14.1489809714062 | 0.890414731995374 | 102.692976014008 | 0.137779442378573 | 507.712885368923 | NA | 1.98848253379833 | 2.1018584548314e-08 | 7.67739653395739 | 10.9022485555592 | Inf | 5.92457926729285e-11 | lineage2 | dr_mutations_pyrazinamide | THR | 0 | SRS797055 | SRR1723558 | lineage2.2.1 | cn | China:Shanxi | pnca_p.met1thr | A | - | MET | MA1 | pnca_complex.pdb |
33 | M1T | L4 | PZA | M | M1 | 1 | T | NA | XDR | DM | hydrophobic | hydrophobic | non-polar | neutral | non-polar | polar | 23.978 | 0.344 | 0.109 | 0.867771 | -1.096 | 0.51 | 52 | 75 | -1.048 | 9 | 9 | 88 | 0.392857142857143 | loop | 0.633333333333333 | 4.12 | 0.0007187005893344 | 97.3828619670747 | 1395803.74890195 | Inf | 42.8452490786805 | 10 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 0.154260089686099 | 0.0926870748299319 | 0.031606108727482 | -0.186871270247229 | 0.286516853932584 | 0.547368421052632 | -0.86326194398682 | Stabilising | Stabilising | Destabilising | Destabilising | Stabilising | effect | -1.178 | -0.993 | 9:9 | 21/150 | V:M | 14.1489809714062 | 0.890414731995374 | 102.692976014008 | 0.137779442378573 | 507.712885368923 | NA | 1.98848253379833 | 2.1018584548314e-08 | 7.67739653395739 | 10.9022485555592 | Inf | 5.92457926729285e-11 | lineage4 | dr_mutations_pyrazinamide | THR | 0 | ERR275230 | ERR275230 | lineage4.3.4.2 | pt | Portugal | pnca_p.met1thr | A | - | MET | MA1 | pnca_complex.pdb |
34 | R2L | L4 | PZA | R | R2 | 2 | L | 0 | Pre-XDR | OM | hydrophilic | hydrophobic | basic | non-polar | pos | non-polar | 21.092 | -2.083 | 0.062 | 1.78755 | -0.708 | -0.24 | 44 | 71 | -0.015 | 5 | 5 | 55 | 0.200729927007299 | strand | -0.266666666666667 | 4.74 | 7.18700589334483e-05 | 2.42412778478352 | 0.0001249735077034 | 0 | 1.03410070803344e-29 | 38 | 30 | 0 | 4 | 26 | 0 | 0 | 0 | 0 | 4 | 0 | 2 | 2 | 0 | 0 | 0 | 0 | 1 | 0 | -2 | 2 | 0 | 0 | 0 | -2 | -0.527608915906788 | 0.0527210884353741 | 0.0651064620225963 | -0.120716112531969 | -0.06282722513089 | 0.463157894736842 | -0.0123558484349259 | Destabilising | Stabilising | Destabilising | Destabilising | Destabilising | effect | -0.244 | 0.083 | 6:5 | 84/150 | R:K:N:H:T:S:E | -8.9874087814964 | 0.940032862253633 | 119.46804443549 | -0.0752285585987755 | NA | 4692673.51081259 | 0.384555509373631 | 1 | 0 | 0 | 188.544222231268 | 0.999999999999997 | lineage4 | other_mutations_pyrazinamide | LEU | 0 | ERR2516706 | ERR2516706 | lineage4 | pe | Peru | pnca_p.arg2leu | A | E | ARG | RA2 | pnca_complex.pdb |
35 | R2P | L4 | PZA | R | R2 | 2 | P | NA | MDR | OM | hydrophilic | hydrophilic | basic | non-polar | pos | non-polar | 21.092 | -2.244 | -1.031 | 4.20376 | -1.935 | -0.43 | 63 | 80 | -0.015 | 5 | 5 | 55 | 0.200729927007299 | strand | -0.266666666666667 | 4.74 | NA | NA | NA | NA | NA | 48 | 28 | 0 | 4 | 24 | 0 | 0 | 0 | 0 | 2 | 0 | 4 | 0 | 0 | 0 | 0 | 0 | 4 | 2 | 1 | 1 | 4 | 0 | 6 | 0 | -0.56838905775076 | -0.26640826873385 | 0.153110089671399 | -0.329923273657289 | -0.112565445026178 | 0.663157894736842 | -0.0123558484349259 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.244 | 0.083 | 6:5 | 84/150 | R:K:N:H:T:S:E | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | lineage4 | other_mutations_pyrazinamide | PRO | 0 | ERR779907 | ERR779907 | lineage4.3.3 | pe | | pnca_p.arg2pro | A | E | ARG | RA2 | pnca_complex.pdb |
36 | R2W | L4 | PZA | R | R2 | 2 | W | NA | Pre-XDR | OM | hydrophilic | hydrophobic | basic | non-polar | pos | non-polar | 21.092 | -1.147 | -0.164 | 4.38565 | -0.74 | -0.16 | 58 | 75 | -0.015 | 5 | 5 | 55 | 0.200729927007299 | strand | -0.266666666666667 | 4.74 | NA | NA | NA | NA | NA | 8 | 30 | 0 | 4 | 26 | 0 | 0 | 0 | 0 | 4 | 0 | 2 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | -5 | 5 | 6 | 0 | 6 | 4 | -0.290526849037487 | -0.0423772609819121 | 0.159734919397723 | -0.12617220801364 | -0.0418848167539267 | 0.610526315789474 | -0.0123558484349259 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.244 | 0.083 | 6:5 | 84/150 | R:K:N:H:T:S:E | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | lineage4 | other_mutations_pyrazinamide | TRP | 0 | SAMN02584674 | SRR1168960_SRR1166135 | lineage4.2.1 | md | Moldova | pnca_p.arg2trp | A | E | ARG | RA2 | pnca_complex.pdb |
37 | A3E | L2 | PZA | A | A3 | 3 | E | 1 | MDR | DM | hydrophobic | hydrophilic | non-polar | acidic | non-polar | neg | 18.028 | -1.552 | -2.829 | 2.75936 | -5.34 | -1.11 | 56 | 75 | -0.873 | 8 | 8 | 0 | 0 | strand | 0.366666666666667 | 8.38 | 0.0002874802357337 | 38.8547368421053 | 1392277.50785087 | Inf | 13.9909822352959 | -30 | -38 | 0 | -2 | -36 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -13 | 0 | -3 | -14 | -4 | 0 | -2 | -9 | -0.393110435663627 | -0.731007751937984 | 0.100501897595408 | -0.910485933503836 | -0.290575916230366 | 0.589473684210526 | -0.719110378912685 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.993 | -0.827 | 9:8 | 141/150 | A:G:T:V:C | 14.1464514590954 | 0.930573112990226 | 162.371849599086 | 0.0871237932808215 | 0.011399544335555 | NA | 1.58944397188817 | 0.0008528275207519 | 3.06913879340442 | 3.20302487654751 | Inf | 0.0001836895199759 | lineage2 | dr_mutations_pyrazinamide | GLU | 0 | MDR_17174 | SRR6824459 | lineage2.2.1 | cn | China: Ma City, Huanggang City,Hubei Province | pnca_p.ala3glu | A | E | ALA | AA3 | pnca_complex.pdb |
38 | A3E | L2 | PZA | A | A3 | 3 | E | NA | MDR | DM | hydrophobic | hydrophilic | non-polar | acidic | non-polar | neg | 18.028 | -1.552 | -2.829 | 2.75936 | -5.34 | -1.11 | 56 | 75 | -0.873 | 8 | 8 | 0 | 0 | strand | 0.366666666666667 | 8.38 | 0.0002874802357337 | 38.8547368421053 | 1392277.50785087 | Inf | 13.9909822352959 | -30 | -38 | 0 | -2 | -36 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -13 | 0 | -3 | -14 | -4 | 0 | -2 | -9 | -0.393110435663627 | -0.731007751937984 | 0.100501897595408 | -0.910485933503836 | -0.290575916230366 | 0.589473684210526 | -0.719110378912685 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.993 | -0.827 | 9:8 | 141/150 | A:G:T:V:C | 14.1464514590954 | 0.930573112990226 | 162.371849599086 | 0.0871237932808215 | 0.011399544335555 | NA | 1.58944397188817 | 0.0008528275207519 | 3.06913879340442 | 3.20302487654751 | Inf | 0.0001836895199759 | lineage2 | dr_mutations_pyrazinamide | GLU | 0 | SRS797278 | SRR1723804 | lineage2.2.1 | cn | China:Hubei | pnca_p.ala3glu | A | E | ALA | AA3 | pnca_complex.pdb |
39 | A3E | L6 | PZA | A | A3 | 3 | E | NA | MDR | DM | hydrophobic | hydrophilic | non-polar | acidic | non-polar | neg | 18.028 | -1.552 | -2.829 | 2.75936 | -5.34 | -1.11 | 56 | 75 | -0.873 | 8 | 8 | 0 | 0 | strand | 0.366666666666667 | 8.38 | 0.0002874802357337 | 38.8547368421053 | 1392277.50785087 | Inf | 13.9909822352959 | -30 | -38 | 0 | -2 | -36 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -13 | 0 | -3 | -14 | -4 | 0 | -2 | -9 | -0.393110435663627 | -0.731007751937984 | 0.100501897595408 | -0.910485933503836 | -0.290575916230366 | 0.589473684210526 | -0.719110378912685 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.993 | -0.827 | 9:8 | 141/150 | A:G:T:V:C | 14.1464514590954 | 0.930573112990226 | 162.371849599086 | 0.0871237932808215 | 0.011399544335555 | NA | 1.58944397188817 | 0.0008528275207519 | 3.06913879340442 | 3.20302487654751 | Inf | 0.0001836895199759 | lineage6 | dr_mutations_pyrazinamide | GLU | 0 | ERR1215461 | ERR1215461 | lineage6 | gh | Ghana | pnca_p.ala3glu | A | E | ALA | AA3 | pnca_complex.pdb |
40 | A3E | L2 | PZA | A | A3 | 3 | E | 1 | MDR | DM | hydrophobic | hydrophilic | non-polar | acidic | non-polar | neg | 18.028 | -1.552 | -2.829 | 2.75936 | -5.34 | -1.11 | 56 | 75 | -0.873 | 8 | 8 | 0 | 0 | strand | 0.366666666666667 | 8.38 | 0.0002874802357337 | 38.8547368421053 | 1392277.50785087 | Inf | 13.9909822352959 | -30 | -38 | 0 | -2 | -36 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -13 | 0 | -3 | -14 | -4 | 0 | -2 | -9 | -0.393110435663627 | -0.731007751937984 | 0.100501897595408 | -0.910485933503836 | -0.290575916230366 | 0.589473684210526 | -0.719110378912685 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.993 | -0.827 | 9:8 | 141/150 | A:G:T:V:C | 14.1464514590954 | 0.930573112990226 | 162.371849599086 | 0.0871237932808215 | 0.011399544335555 | NA | 1.58944397188817 | 0.0008528275207519 | 3.06913879340442 | 3.20302487654751 | Inf | 0.0001836895199759 | lineage2 | dr_mutations_pyrazinamide | GLU | 0 | MDR_17238 | SRR6824452 | lineage2.2.1 | cn | China: Ma City, Huanggang City,Hubei Province | pnca_p.ala3glu | A | E | ALA | AA3 | pnca_complex.pdb |
41 | A3E | L2 | PZA | A | A3 | 3 | E | 1 | XDR | DM | hydrophobic | hydrophilic | non-polar | acidic | non-polar | neg | 18.028 | -1.552 | -2.829 | 2.75936 | -5.34 | -1.11 | 56 | 75 | -0.873 | 8 | 8 | 0 | 0 | strand | 0.366666666666667 | 8.38 | 0.0002874802357337 | 38.8547368421053 | 1392277.50785087 | Inf | 13.9909822352959 | -30 | -38 | 0 | -2 | -36 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -13 | 0 | -3 | -14 | -4 | 0 | -2 | -9 | -0.393110435663627 | -0.731007751937984 | 0.100501897595408 | -0.910485933503836 | -0.290575916230366 | 0.589473684210526 | -0.719110378912685 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.993 | -0.827 | 9:8 | 141/150 | A:G:T:V:C | 14.1464514590954 | 0.930573112990226 | 162.371849599086 | 0.0871237932808215 | 0.011399544335555 | NA | 1.58944397188817 | 0.0008528275207519 | 3.06913879340442 | 3.20302487654751 | Inf | 0.0001836895199759 | lineage2 | dr_mutations_pyrazinamide | GLU | 0 | ERR067750,0450Q-sc-2011-08-25T12:38:41Z-1262349 | ERR067750 | lineage2.2.1 | ru | Russia,Samara | pnca_p.ala3glu | A | E | ALA | AA3 | pnca_complex.pdb |
42 | A3E | L2 | PZA | A | A3 | 3 | E | 1 | Pre-XDR | DM | hydrophobic | hydrophilic | non-polar | acidic | non-polar | neg | 18.028 | -1.552 | -2.829 | 2.75936 | -5.34 | -1.11 | 56 | 75 | -0.873 | 8 | 8 | 0 | 0 | strand | 0.366666666666667 | 8.38 | 0.0002874802357337 | 38.8547368421053 | 1392277.50785087 | Inf | 13.9909822352959 | -30 | -38 | 0 | -2 | -36 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -13 | 0 | -3 | -14 | -4 | 0 | -2 | -9 | -0.393110435663627 | -0.731007751937984 | 0.100501897595408 | -0.910485933503836 | -0.290575916230366 | 0.589473684210526 | -0.719110378912685 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.993 | -0.827 | 9:8 | 141/150 | A:G:T:V:C | 14.1464514590954 | 0.930573112990226 | 162.371849599086 | 0.0871237932808215 | 0.011399544335555 | NA | 1.58944397188817 | 0.0008528275207519 | 3.06913879340442 | 3.20302487654751 | Inf | 0.0001836895199759 | lineage2 | dr_mutations_pyrazinamide | GLU | 0 | ETB0012 | SRR6256984 | lineage2.2.1 | ru | Russia:Arkhangelsk | pnca_p.ala3glu | A | E | ALA | AA3 | pnca_complex.pdb |
43 | A3P | L4 | PZA | A | A3 | 3 | P | NA | Pre-XDR | DM | hydrophobic | hydrophilic | non-polar | non-polar | non-polar | non-polar | 18.028 | -2.664 | -1.124 | -0.155697 | -3.837 | -0.13 | 66 | 80 | -0.873 | 8 | 8 | 0 | 0 | strand | 0.366666666666667 | 8.38 | 7.18700589334483e-05 | 9.70142977291842 | 188179.926264599 | Inf | 0.763784339928386 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 2 | -7 | -4 | -2 | 0 | -2 | -1 | -0.674772036474164 | -0.290439276485788 | -0.0299348227332154 | -0.654219948849105 | -0.0340314136125654 | 0.694736842105263 | -0.719110378912685 | Destabilising | Destabilising | Stabilising | Destabilising | Destabilising | effect | -0.993 | -0.827 | 9:8 | 141/150 | A:G:T:V:C | 12.1451538387263 | 0.919026337424228 | 119.468044436222 | 0.101660271548263 | 5.01153666063644e-06 | NA | 0.986835744238421 | 0.170978870202674 | 0.767057556984365 | 0.124324963210678 | Inf | 0.382146811758261 | lineage4 | dr_mutations_pyrazinamide | PRO | 0 | 3200 | ERR2432999 | lineage4.1.2.1 | br | Brazil | pnca_p.ala3pro | A | E | ALA | AA3 | pnca_complex.pdb |
44 | A3P | L4 | PZA | A | A3 | 3 | P | NA | MDR | DM | hydrophobic | hydrophilic | non-polar | non-polar | non-polar | non-polar | 18.028 | -2.664 | -1.124 | -0.155697 | -3.837 | -0.13 | 66 | 80 | -0.873 | 8 | 8 | 0 | 0 | strand | 0.366666666666667 | 8.38 | 7.18700589334483e-05 | 9.70142977291842 | 188179.926264599 | Inf | 0.763784339928386 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 2 | -7 | -4 | -2 | 0 | -2 | -1 | -0.674772036474164 | -0.290439276485788 | -0.0299348227332154 | -0.654219948849105 | -0.0340314136125654 | 0.694736842105263 | -0.719110378912685 | Destabilising | Destabilising | Stabilising | Destabilising | Destabilising | effect | -0.993 | -0.827 | 9:8 | 141/150 | A:G:T:V:C | 12.1451538387263 | 0.919026337424228 | 119.468044436222 | 0.101660271548263 | 5.01153666063644e-06 | NA | 0.986835744238421 | 0.170978870202674 | 0.767057556984365 | 0.124324963210678 | Inf | 0.382146811758261 | lineage4 | dr_mutations_pyrazinamide | PRO | 0 | 1662 | ERR2432989 | lineage4.1.2.1 | br | Brazil | pnca_p.ala3pro | A | E | ALA | AA3 | pnca_complex.pdb |
45 | A3P | L4 | PZA | A | A3 | 3 | P | 1 | MDR | DM | hydrophobic | hydrophilic | non-polar | non-polar | non-polar | non-polar | 18.028 | -2.664 | -1.124 | -0.155697 | -3.837 | -0.13 | 66 | 80 | -0.873 | 8 | 8 | 0 | 0 | strand | 0.366666666666667 | 8.38 | 7.18700589334483e-05 | 9.70142977291842 | 188179.926264599 | Inf | 0.763784339928386 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 2 | -7 | -4 | -2 | 0 | -2 | -1 | -0.674772036474164 | -0.290439276485788 | -0.0299348227332154 | -0.654219948849105 | -0.0340314136125654 | 0.694736842105263 | -0.719110378912685 | Destabilising | Destabilising | Stabilising | Destabilising | Destabilising | effect | -0.993 | -0.827 | 9:8 | 141/150 | A:G:T:V:C | 12.1451538387263 | 0.919026337424228 | 119.468044436222 | 0.101660271548263 | 5.01153666063644e-06 | NA | 0.986835744238421 | 0.170978870202674 | 0.767057556984365 | 0.124324963210678 | Inf | 0.382146811758261 | lineage4 | dr_mutations_pyrazinamide | PRO | 0 | 10982 | ERR3014600 | lineage4.1.2.1 | tn | Tunisia:Tunis | pnca_p.ala3pro | A | E | ALA | AA3 | pnca_complex.pdb |
46 | L4S | L2 | PZA | L | L4 | 4 | S | 1 | MDR | DM | hydrophobic | hydrophilic | non-polar | neutral | non-polar | polar | 15.328 | -1.078 | -3.87 | 5.57838 | -2.638 | -3.7 | 63 | 80 | -1.075 | 9 | 9 | 0 | 0 | strand | 3.36666666666667 | 8.8 | 0.0024435820037372 | 28.4570212765957 | 28.4570177059942 | 28.4308865607855 | 107.057952768928 | 22 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 0 | -3 | 0 | -1 | -2 | 6 | 0 | 4 | 6 | -0.273049645390071 | -1 | 0.203176742254824 | -0.449786871270247 | -0.968586387434555 | 0.663157894736842 | -0.885502471169687 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.152 | -1.028 | 9:9 | 146/150 | F:V:L:I | 3.34839479820379 | 4.89069202996555e-12 | 0.484662577645081 | 6.90871330415739 | 12.0071584873314 | 83.7151686983107 | 1.4541894385859 | 5.6263316435115e-18 | 17.2497746719749 | 10.8739157094292 | 94.2522723934353 | 4.32340113554558e-25 | lineage2 | dr_mutations_pyrazinamide | SER | 0 | ERR2516880 | ERR2516880 | lineage2.2.1 | gb | UK | pnca_p.leu4ser | A | E | LEU | LA4 | pnca_complex.pdb |
47 | L4S | L3 | PZA | L | L4 | 4 | S | 1 | Pre-MDR | DM | hydrophobic | hydrophilic | non-polar | neutral | non-polar | polar | 15.328 | -1.078 | -3.87 | 5.57838 | -2.638 | -3.7 | 63 | 80 | -1.075 | 9 | 9 | 0 | 0 | strand | 3.36666666666667 | 8.8 | 0.0024435820037372 | 28.4570212765957 | 28.4570177059942 | 28.4308865607855 | 107.057952768928 | 22 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 0 | -3 | 0 | -1 | -2 | 6 | 0 | 4 | 6 | -0.273049645390071 | -1 | 0.203176742254824 | -0.449786871270247 | -0.968586387434555 | 0.663157894736842 | -0.885502471169687 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.152 | -1.028 | 9:9 | 146/150 | F:V:L:I | 3.34839479820379 | 4.89069202996555e-12 | 0.484662577645081 | 6.90871330415739 | 12.0071584873314 | 83.7151686983107 | 1.4541894385859 | 5.6263316435115e-18 | 17.2497746719749 | 10.8739157094292 | 94.2522723934353 | 4.32340113554558e-25 | lineage3 | dr_mutations_pyrazinamide | SER | 0 | ERR2510458 | ERR2510458 | lineage3.1.2.1 | pk | Pakistan | pnca_p.leu4ser | A | E | LEU | LA4 | pnca_complex.pdb |
48 | L4S | L4 | PZA | L | L4 | 4 | S | NA | MDR | DM | hydrophobic | hydrophilic | non-polar | neutral | non-polar | polar | 15.328 | -1.078 | -3.87 | 5.57838 | -2.638 | -3.7 | 63 | 80 | -1.075 | 9 | 9 | 0 | 0 | strand | 3.36666666666667 | 8.8 | 0.0024435820037372 | 28.4570212765957 | 28.4570177059942 | 28.4308865607855 | 107.057952768928 | 22 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 0 | -3 | 0 | -1 | -2 | 6 | 0 | 4 | 6 | -0.273049645390071 | -1 | 0.203176742254824 | -0.449786871270247 | -0.968586387434555 | 0.663157894736842 | -0.885502471169687 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.152 | -1.028 | 9:9 | 146/150 | F:V:L:I | 3.34839479820379 | 4.89069202996555e-12 | 0.484662577645081 | 6.90871330415739 | 12.0071584873314 | 83.7151686983107 | 1.4541894385859 | 5.6263316435115e-18 | 17.2497746719749 | 10.8739157094292 | 94.2522723934353 | 4.32340113554558e-25 | lineage4 | dr_mutations_pyrazinamide | SER | 0 | ERR2516569 | ERR2516569 | lineage4.3.3 | nl | Netherlands | pnca_p.leu4ser | A | E | LEU | LA4 | pnca_complex.pdb |
49 | L4S | L2 | PZA | L | L4 | 4 | S | 1 | MDR | DM | hydrophobic | hydrophilic | non-polar | neutral | non-polar | polar | 15.328 | -1.078 | -3.87 | 5.57838 | -2.638 | -3.7 | 63 | 80 | -1.075 | 9 | 9 | 0 | 0 | strand | 3.36666666666667 | 8.8 | 0.0024435820037372 | 28.4570212765957 | 28.4570177059942 | 28.4308865607855 | 107.057952768928 | 22 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 0 | -3 | 0 | -1 | -2 | 6 | 0 | 4 | 6 | -0.273049645390071 | -1 | 0.203176742254824 | -0.449786871270247 | -0.968586387434555 | 0.663157894736842 | -0.885502471169687 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.152 | -1.028 | 9:9 | 146/150 | F:V:L:I | 3.34839479820379 | 4.89069202996555e-12 | 0.484662577645081 | 6.90871330415739 | 12.0071584873314 | 83.7151686983107 | 1.4541894385859 | 5.6263316435115e-18 | 17.2497746719749 | 10.8739157094292 | 94.2522723934353 | 4.32340113554558e-25 | lineage2 | dr_mutations_pyrazinamide | SER | 0 | SRR2100387,SAMN03647560 | SRR2100387 | lineage2.2.1 | | | pnca_p.leu4ser | A | E | LEU | LA4 | pnca_complex.pdb |
50 | L4S | L2 | PZA | L | L4 | 4 | S | 0 | MDR | DM | hydrophobic | hydrophilic | non-polar | neutral | non-polar | polar | 15.328 | -1.078 | -3.87 | 5.57838 | -2.638 | -3.7 | 63 | 80 | -1.075 | 9 | 9 | 0 | 0 | strand | 3.36666666666667 | 8.8 | 0.0024435820037372 | 28.4570212765957 | 28.4570177059942 | 28.4308865607855 | 107.057952768928 | 22 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 0 | -3 | 0 | -1 | -2 | 6 | 0 | 4 | 6 | -0.273049645390071 | -1 | 0.203176742254824 | -0.449786871270247 | -0.968586387434555 | 0.663157894736842 | -0.885502471169687 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.152 | -1.028 | 9:9 | 146/150 | F:V:L:I | 3.34839479820379 | 4.89069202996555e-12 | 0.484662577645081 | 6.90871330415739 | 12.0071584873314 | 83.7151686983107 | 1.4541894385859 | 5.6263316435115e-18 | 17.2497746719749 | 10.8739157094292 | 94.2522723934353 | 4.32340113554558e-25 | lineage2 | dr_mutations_pyrazinamide | SER | 0 | ERR2516991 | ERR2516991 | lineage2.2.1 | gb | UK | pnca_p.leu4ser | A | E | LEU | LA4 | pnca_complex.pdb |
51 | L4S | L2 | PZA | L | L4 | 4 | S | 0 | MDR | DM | hydrophobic | hydrophilic | non-polar | neutral | non-polar | polar | 15.328 | -1.078 | -3.87 | 5.57838 | -2.638 | -3.7 | 63 | 80 | -1.075 | 9 | 9 | 0 | 0 | strand | 3.36666666666667 | 8.8 | 0.0024435820037372 | 28.4570212765957 | 28.4570177059942 | 28.4308865607855 | 107.057952768928 | 22 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 0 | -3 | 0 | -1 | -2 | 6 | 0 | 4 | 6 | -0.273049645390071 | -1 | 0.203176742254824 | -0.449786871270247 | -0.968586387434555 | 0.663157894736842 | -0.885502471169687 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.152 | -1.028 | 9:9 | 146/150 | F:V:L:I | 3.34839479820379 | 4.89069202996555e-12 | 0.484662577645081 | 6.90871330415739 | 12.0071584873314 | 83.7151686983107 | 1.4541894385859 | 5.6263316435115e-18 | 17.2497746719749 | 10.8739157094292 | 94.2522723934353 | 4.32340113554558e-25 | lineage2 | dr_mutations_pyrazinamide | SER | 0 | ERR2517006 | ERR2517006 | lineage2.2.1 | gb | UK | pnca_p.leu4ser | A | E | LEU | LA4 | pnca_complex.pdb |
52 | L4S | L2 | PZA | L | L4 | 4 | S | 1 | XDR | DM | hydrophobic | hydrophilic | non-polar | neutral | non-polar | polar | 15.328 | -1.078 | -3.87 | 5.57838 | -2.638 | -3.7 | 63 | 80 | -1.075 | 9 | 9 | 0 | 0 | strand | 3.36666666666667 | 8.8 | 0.0024435820037372 | 28.4570212765957 | 28.4570177059942 | 28.4308865607855 | 107.057952768928 | 22 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 0 | -3 | 0 | -1 | -2 | 6 | 0 | 4 | 6 | -0.273049645390071 | -1 | 0.203176742254824 | -0.449786871270247 | -0.968586387434555 | 0.663157894736842 | -0.885502471169687 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.152 | -1.028 | 9:9 | 146/150 | F:V:L:I | 3.34839479820379 | 4.89069202996555e-12 | 0.484662577645081 | 6.90871330415739 | 12.0071584873314 | 83.7151686983107 | 1.4541894385859 | 5.6263316435115e-18 | 17.2497746719749 | 10.8739157094292 | 94.2522723934353 | 4.32340113554558e-25 | lineage2 | dr_mutations_pyrazinamide | SER | 0 | ERS1831676 | ERR2041944 | lineage2.2.1 | | Germany_extendedCAO | pnca_p.leu4ser | A | E | LEU | LA4 | pnca_complex.pdb |
53 | L4S | L2 | PZA | L | L4 | 4 | S | NA | MDR | DM | hydrophobic | hydrophilic | non-polar | neutral | non-polar | polar | 15.328 | -1.078 | -3.87 | 5.57838 | -2.638 | -3.7 | 63 | 80 | -1.075 | 9 | 9 | 0 | 0 | strand | 3.36666666666667 | 8.8 | 0.0024435820037372 | 28.4570212765957 | 28.4570177059942 | 28.4308865607855 | 107.057952768928 | 22 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 0 | -3 | 0 | -1 | -2 | 6 | 0 | 4 | 6 | -0.273049645390071 | -1 | 0.203176742254824 | -0.449786871270247 | -0.968586387434555 | 0.663157894736842 | -0.885502471169687 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.152 | -1.028 | 9:9 | 146/150 | F:V:L:I | 3.34839479820379 | 4.89069202996555e-12 | 0.484662577645081 | 6.90871330415739 | 12.0071584873314 | 83.7151686983107 | 1.4541894385859 | 5.6263316435115e-18 | 17.2497746719749 | 10.8739157094292 | 94.2522723934353 | 4.32340113554558e-25 | lineage2 | dr_mutations_pyrazinamide | SER | 0 | ERR1023353 | ERR1023353 | lineage2.2.1 | | | pnca_p.leu4ser | A | E | LEU | LA4 | pnca_complex.pdb |
54 | L4S | L4 | PZA | L | L4 | 4 | S | 1 | Pre-XDR | DM | hydrophobic | hydrophilic | non-polar | neutral | non-polar | polar | 15.328 | -1.078 | -3.87 | 5.57838 | -2.638 | -3.7 | 63 | 80 | -1.075 | 9 | 9 | 0 | 0 | strand | 3.36666666666667 | 8.8 | 0.0024435820037372 | 28.4570212765957 | 28.4570177059942 | 28.4308865607855 | 107.057952768928 | 22 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 0 | -3 | 0 | -1 | -2 | 6 | 0 | 4 | 6 | -0.273049645390071 | -1 | 0.203176742254824 | -0.449786871270247 | -0.968586387434555 | 0.663157894736842 | -0.885502471169687 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.152 | -1.028 | 9:9 | 146/150 | F:V:L:I | 3.34839479820379 | 4.89069202996555e-12 | 0.484662577645081 | 6.90871330415739 | 12.0071584873314 | 83.7151686983107 | 1.4541894385859 | 5.6263316435115e-18 | 17.2497746719749 | 10.8739157094292 | 94.2522723934353 | 4.32340113554558e-25 | lineage4 | dr_mutations_pyrazinamide | SER | 0 | ERR2513221 | ERR2513221 | lineage4 | gb | UK | pnca_p.leu4ser | A | E | LEU | LA4 | pnca_complex.pdb |
55 | L4S | L2 | PZA | L | L4 | 4 | S | NA | XDR | DM | hydrophobic | hydrophilic | non-polar | neutral | non-polar | polar | 15.328 | -1.078 | -3.87 | 5.57838 | -2.638 | -3.7 | 63 | 80 | -1.075 | 9 | 9 | 0 | 0 | strand | 3.36666666666667 | 8.8 | 0.0024435820037372 | 28.4570212765957 | 28.4570177059942 | 28.4308865607855 | 107.057952768928 | 22 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 0 | -3 | 0 | -1 | -2 | 6 | 0 | 4 | 6 | -0.273049645390071 | -1 | 0.203176742254824 | -0.449786871270247 | -0.968586387434555 | 0.663157894736842 | -0.885502471169687 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.152 | -1.028 | 9:9 | 146/150 | F:V:L:I | 3.34839479820379 | 4.89069202996555e-12 | 0.484662577645081 | 6.90871330415739 | 12.0071584873314 | 83.7151686983107 | 1.4541894385859 | 5.6263316435115e-18 | 17.2497746719749 | 10.8739157094292 | 94.2522723934353 | 4.32340113554558e-25 | lineage2 | dr_mutations_pyrazinamide | SER | 0 | BGI_GuangZ0017,SRR671864 | SRR671864 | lineage2.2.1 | cn | China | pnca_p.leu4ser | A | E | LEU | LA4 | pnca_complex.pdb |
56 | L4S | L2 | PZA | L | L4 | 4 | S | 1 | MDR | DM | hydrophobic | hydrophilic | non-polar | neutral | non-polar | polar | 15.328 | -1.078 | -3.87 | 5.57838 | -2.638 | -3.7 | 63 | 80 | -1.075 | 9 | 9 | 0 | 0 | strand | 3.36666666666667 | 8.8 | 0.0024435820037372 | 28.4570212765957 | 28.4570177059942 | 28.4308865607855 | 107.057952768928 | 22 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 0 | -3 | 0 | -1 | -2 | 6 | 0 | 4 | 6 | -0.273049645390071 | -1 | 0.203176742254824 | -0.449786871270247 | -0.968586387434555 | 0.663157894736842 | -0.885502471169687 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.152 | -1.028 | 9:9 | 146/150 | F:V:L:I | 3.34839479820379 | 4.89069202996555e-12 | 0.484662577645081 | 6.90871330415739 | 12.0071584873314 | 83.7151686983107 | 1.4541894385859 | 5.6263316435115e-18 | 17.2497746719749 | 10.8739157094292 | 94.2522723934353 | 4.32340113554558e-25 | lineage2 | dr_mutations_pyrazinamide | SER | 0 | ERR2513564 | ERR2513564 | lineage2.2.1 | gb | UK | pnca_p.leu4ser | A | E | LEU | LA4 | pnca_complex.pdb |
57 | L4S | L4 | PZA | L | L4 | 4 | S | 1 | MDR | DM | hydrophobic | hydrophilic | non-polar | neutral | non-polar | polar | 15.328 | -1.078 | -3.87 | 5.57838 | -2.638 | -3.7 | 63 | 80 | -1.075 | 9 | 9 | 0 | 0 | strand | 3.36666666666667 | 8.8 | 0.0024435820037372 | 28.4570212765957 | 28.4570177059942 | 28.4308865607855 | 107.057952768928 | 22 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 0 | -3 | 0 | -1 | -2 | 6 | 0 | 4 | 6 | -0.273049645390071 | -1 | 0.203176742254824 | -0.449786871270247 | -0.968586387434555 | 0.663157894736842 | -0.885502471169687 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.152 | -1.028 | 9:9 | 146/150 | F:V:L:I | 3.34839479820379 | 4.89069202996555e-12 | 0.484662577645081 | 6.90871330415739 | 12.0071584873314 | 83.7151686983107 | 1.4541894385859 | 5.6263316435115e-18 | 17.2497746719749 | 10.8739157094292 | 94.2522723934353 | 4.32340113554558e-25 | lineage4 | dr_mutations_pyrazinamide | SER | 0 | ERS2592809 | ERR2677466 | lineage4.2.2.1 | de | Germany | pnca_p.leu4ser | A | E | LEU | LA4 | pnca_complex.pdb |
58 | L4S | L2 | PZA | L | L4 | 4 | S | 1 | MDR | DM | hydrophobic | hydrophilic | non-polar | neutral | non-polar | polar | 15.328 | -1.078 | -3.87 | 5.57838 | -2.638 | -3.7 | 63 | 80 | -1.075 | 9 | 9 | 0 | 0 | strand | 3.36666666666667 | 8.8 | 0.0024435820037372 | 28.4570212765957 | 28.4570177059942 | 28.4308865607855 | 107.057952768928 | 22 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 0 | -3 | 0 | -1 | -2 | 6 | 0 | 4 | 6 | -0.273049645390071 | -1 | 0.203176742254824 | -0.449786871270247 | -0.968586387434555 | 0.663157894736842 | -0.885502471169687 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.152 | -1.028 | 9:9 | 146/150 | F:V:L:I | 3.34839479820379 | 4.89069202996555e-12 | 0.484662577645081 | 6.90871330415739 | 12.0071584873314 | 83.7151686983107 | 1.4541894385859 | 5.6263316435115e-18 | 17.2497746719749 | 10.8739157094292 | 94.2522723934353 | 4.32340113554558e-25 | lineage2 | dr_mutations_pyrazinamide | SER | 0 | ERR1034880 | ERR1034880 | lineage2.2.1 | pt | Portugal | pnca_p.leu4ser | A | E | LEU | LA4 | pnca_complex.pdb |
59 | L4S | L2 | PZA | L | L4 | 4 | S | 1 | MDR | DM | hydrophobic | hydrophilic | non-polar | neutral | non-polar | polar | 15.328 | -1.078 | -3.87 | 5.57838 | -2.638 | -3.7 | 63 | 80 | -1.075 | 9 | 9 | 0 | 0 | strand | 3.36666666666667 | 8.8 | 0.0024435820037372 | 28.4570212765957 | 28.4570177059942 | 28.4308865607855 | 107.057952768928 | 22 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 0 | -3 | 0 | -1 | -2 | 6 | 0 | 4 | 6 | -0.273049645390071 | -1 | 0.203176742254824 | -0.449786871270247 | -0.968586387434555 | 0.663157894736842 | -0.885502471169687 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.152 | -1.028 | 9:9 | 146/150 | F:V:L:I | 3.34839479820379 | 4.89069202996555e-12 | 0.484662577645081 | 6.90871330415739 | 12.0071584873314 | 83.7151686983107 | 1.4541894385859 | 5.6263316435115e-18 | 17.2497746719749 | 10.8739157094292 | 94.2522723934353 | 4.32340113554558e-25 | lineage2 | dr_mutations_pyrazinamide | SER | 0 | ERR2516854 | ERR2516854 | lineage2.2.1 | gb | UK | pnca_p.leu4ser | A | E | LEU | LA4 | pnca_complex.pdb |
60 | L4S | L2 | PZA | L | L4 | 4 | S | 0 | MDR | DM | hydrophobic | hydrophilic | non-polar | neutral | non-polar | polar | 15.328 | -1.078 | -3.87 | 5.57838 | -2.638 | -3.7 | 63 | 80 | -1.075 | 9 | 9 | 0 | 0 | strand | 3.36666666666667 | 8.8 | 0.0024435820037372 | 28.4570212765957 | 28.4570177059942 | 28.4308865607855 | 107.057952768928 | 22 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 0 | -3 | 0 | -1 | -2 | 6 | 0 | 4 | 6 | -0.273049645390071 | -1 | 0.203176742254824 | -0.449786871270247 | -0.968586387434555 | 0.663157894736842 | -0.885502471169687 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.152 | -1.028 | 9:9 | 146/150 | F:V:L:I | 3.34839479820379 | 4.89069202996555e-12 | 0.484662577645081 | 6.90871330415739 | 12.0071584873314 | 83.7151686983107 | 1.4541894385859 | 5.6263316435115e-18 | 17.2497746719749 | 10.8739157094292 | 94.2522723934353 | 4.32340113554558e-25 | lineage2 | dr_mutations_pyrazinamide | SER | 0 | ERR2513572 | ERR2513572 | lineage2.2.1 | gb | UK | pnca_p.leu4ser | A | E | LEU | LA4 | pnca_complex.pdb |
61 | L4S | L2 | PZA | L | L4 | 4 | S | 1 | MDR | DM | hydrophobic | hydrophilic | non-polar | neutral | non-polar | polar | 15.328 | -1.078 | -3.87 | 5.57838 | -2.638 | -3.7 | 63 | 80 | -1.075 | 9 | 9 | 0 | 0 | strand | 3.36666666666667 | 8.8 | 0.0024435820037372 | 28.4570212765957 | 28.4570177059942 | 28.4308865607855 | 107.057952768928 | 22 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 0 | -3 | 0 | -1 | -2 | 6 | 0 | 4 | 6 | -0.273049645390071 | -1 | 0.203176742254824 | -0.449786871270247 | -0.968586387434555 | 0.663157894736842 | -0.885502471169687 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.152 | -1.028 | 9:9 | 146/150 | F:V:L:I | 3.34839479820379 | 4.89069202996555e-12 | 0.484662577645081 | 6.90871330415739 | 12.0071584873314 | 83.7151686983107 | 1.4541894385859 | 5.6263316435115e-18 | 17.2497746719749 | 10.8739157094292 | 94.2522723934353 | 4.32340113554558e-25 | lineage2 | dr_mutations_pyrazinamide | SER | 0 | ERR2512591 | ERR2512591 | lineage2.2.1 | gb | UK | pnca_p.leu4ser | A | E | LEU | LA4 | pnca_complex.pdb |
62 | L4S | L4 | PZA | L | L4 | 4 | S | 1 | Other | DM | hydrophobic | hydrophilic | non-polar | neutral | non-polar | polar | 15.328 | -1.078 | -3.87 | 5.57838 | -2.638 | -3.7 | 63 | 80 | -1.075 | 9 | 9 | 0 | 0 | strand | 3.36666666666667 | 8.8 | 0.0024435820037372 | 28.4570212765957 | 28.4570177059942 | 28.4308865607855 | 107.057952768928 | 22 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 0 | -3 | 0 | -1 | -2 | 6 | 0 | 4 | 6 | -0.273049645390071 | -1 | 0.203176742254824 | -0.449786871270247 | -0.968586387434555 | 0.663157894736842 | -0.885502471169687 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.152 | -1.028 | 9:9 | 146/150 | F:V:L:I | 3.34839479820379 | 4.89069202996555e-12 | 0.484662577645081 | 6.90871330415739 | 12.0071584873314 | 83.7151686983107 | 1.4541894385859 | 5.6263316435115e-18 | 17.2497746719749 | 10.8739157094292 | 94.2522723934353 | 4.32340113554558e-25 | lineage4 | dr_mutations_pyrazinamide | SER | 0 | ERR2510742 | ERR2510742 | lineage4.1.2.1 | it | Italy | pnca_p.leu4ser | A | E | LEU | LA4 | pnca_complex.pdb |
63 | L4S | L2 | PZA | L | L4 | 4 | S | 1 | MDR | DM | hydrophobic | hydrophilic | non-polar | neutral | non-polar | polar | 15.328 | -1.078 | -3.87 | 5.57838 | -2.638 | -3.7 | 63 | 80 | -1.075 | 9 | 9 | 0 | 0 | strand | 3.36666666666667 | 8.8 | 0.0024435820037372 | 28.4570212765957 | 28.4570177059942 | 28.4308865607855 | 107.057952768928 | 22 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 0 | -3 | 0 | -1 | -2 | 6 | 0 | 4 | 6 | -0.273049645390071 | -1 | 0.203176742254824 | -0.449786871270247 | -0.968586387434555 | 0.663157894736842 | -0.885502471169687 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.152 | -1.028 | 9:9 | 146/150 | F:V:L:I | 3.34839479820379 | 4.89069202996555e-12 | 0.484662577645081 | 6.90871330415739 | 12.0071584873314 | 83.7151686983107 | 1.4541894385859 | 5.6263316435115e-18 | 17.2497746719749 | 10.8739157094292 | 94.2522723934353 | 4.32340113554558e-25 | lineage2 | dr_mutations_pyrazinamide | SER | 0 | SRR2100950,SAMN03648197 | SRR2100950 | lineage2.2.1 | | | pnca_p.leu4ser | A | E | LEU | LA4 | pnca_complex.pdb |
64 | L4S | L3 | PZA | L | L4 | 4 | S | 1 | MDR | DM | hydrophobic | hydrophilic | non-polar | neutral | non-polar | polar | 15.328 | -1.078 | -3.87 | 5.57838 | -2.638 | -3.7 | 63 | 80 | -1.075 | 9 | 9 | 0 | 0 | strand | 3.36666666666667 | 8.8 | 0.0024435820037372 | 28.4570212765957 | 28.4570177059942 | 28.4308865607855 | 107.057952768928 | 22 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 0 | -3 | 0 | -1 | -2 | 6 | 0 | 4 | 6 | -0.273049645390071 | -1 | 0.203176742254824 | -0.449786871270247 | -0.968586387434555 | 0.663157894736842 | -0.885502471169687 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.152 | -1.028 | 9:9 | 146/150 | F:V:L:I | 3.34839479820379 | 4.89069202996555e-12 | 0.484662577645081 | 6.90871330415739 | 12.0071584873314 | 83.7151686983107 | 1.4541894385859 | 5.6263316435115e-18 | 17.2497746719749 | 10.8739157094292 | 94.2522723934353 | 4.32340113554558e-25 | lineage3 | dr_mutations_pyrazinamide | SER | 0 | ERR2510570 | ERR2510570 | lineage3 | pk | Pakistan | pnca_p.leu4ser | A | E | LEU | LA4 | pnca_complex.pdb |
65 | L4S | L2 | PZA | L | L4 | 4 | S | NA | XDR | DM | hydrophobic | hydrophilic | non-polar | neutral | non-polar | polar | 15.328 | -1.078 | -3.87 | 5.57838 | -2.638 | -3.7 | 63 | 80 | -1.075 | 9 | 9 | 0 | 0 | strand | 3.36666666666667 | 8.8 | 0.0024435820037372 | 28.4570212765957 | 28.4570177059942 | 28.4308865607855 | 107.057952768928 | 22 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 0 | -3 | 0 | -1 | -2 | 6 | 0 | 4 | 6 | -0.273049645390071 | -1 | 0.203176742254824 | -0.449786871270247 | -0.968586387434555 | 0.663157894736842 | -0.885502471169687 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.152 | -1.028 | 9:9 | 146/150 | F:V:L:I | 3.34839479820379 | 4.89069202996555e-12 | 0.484662577645081 | 6.90871330415739 | 12.0071584873314 | 83.7151686983107 | 1.4541894385859 | 5.6263316435115e-18 | 17.2497746719749 | 10.8739157094292 | 94.2522723934353 | 4.32340113554558e-25 | lineage2 | dr_mutations_pyrazinamide | SER | 0 | SRR5266534 | SRR5266534 | lineage2.2.1 | ru | Russia | pnca_p.leu4ser | A | E | LEU | LA4 | pnca_complex.pdb |
66 | L4S | L4 | PZA | L | L4 | 4 | S | NA | Pre-XDR | DM | hydrophobic | hydrophilic | non-polar | neutral | non-polar | polar | 15.328 | -1.078 | -3.87 | 5.57838 | -2.638 | -3.7 | 63 | 80 | -1.075 | 9 | 9 | 0 | 0 | strand | 3.36666666666667 | 8.8 | 0.0024435820037372 | 28.4570212765957 | 28.4570177059942 | 28.4308865607855 | 107.057952768928 | 22 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 0 | -3 | 0 | -1 | -2 | 6 | 0 | 4 | 6 | -0.273049645390071 | -1 | 0.203176742254824 | -0.449786871270247 | -0.968586387434555 | 0.663157894736842 | -0.885502471169687 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.152 | -1.028 | 9:9 | 146/150 | F:V:L:I | 3.34839479820379 | 4.89069202996555e-12 | 0.484662577645081 | 6.90871330415739 | 12.0071584873314 | 83.7151686983107 | 1.4541894385859 | 5.6263316435115e-18 | 17.2497746719749 | 10.8739157094292 | 94.2522723934353 | 4.32340113554558e-25 | lineage4 | dr_mutations_pyrazinamide | SER | 0 | SAMN02381040 | SRR1049730_SRR1140739_SRR1049729_SRR1062930 | lineage4 | ug | Uganda | pnca_p.leu4ser | A | E | LEU | LA4 | pnca_complex.pdb |
67 | L4S | L2 | PZA | L | L4 | 4 | S | 1 | MDR | DM | hydrophobic | hydrophilic | non-polar | neutral | non-polar | polar | 15.328 | -1.078 | -3.87 | 5.57838 | -2.638 | -3.7 | 63 | 80 | -1.075 | 9 | 9 | 0 | 0 | strand | 3.36666666666667 | 8.8 | 0.0024435820037372 | 28.4570212765957 | 28.4570177059942 | 28.4308865607855 | 107.057952768928 | 22 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 0 | -3 | 0 | -1 | -2 | 6 | 0 | 4 | 6 | -0.273049645390071 | -1 | 0.203176742254824 | -0.449786871270247 | -0.968586387434555 | 0.663157894736842 | -0.885502471169687 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.152 | -1.028 | 9:9 | 146/150 | F:V:L:I | 3.34839479820379 | 4.89069202996555e-12 | 0.484662577645081 | 6.90871330415739 | 12.0071584873314 | 83.7151686983107 | 1.4541894385859 | 5.6263316435115e-18 | 17.2497746719749 | 10.8739157094292 | 94.2522723934353 | 4.32340113554558e-25 | lineage2 | dr_mutations_pyrazinamide | SER | 0 | ERR2512419 | ERR2512419 | lineage2.2.1 | gb | UK | pnca_p.leu4ser | A | E | LEU | LA4 | pnca_complex.pdb |
68 | L4S | L2 | PZA | L | L4 | 4 | S | NA | XDR | DM | hydrophobic | hydrophilic | non-polar | neutral | non-polar | polar | 15.328 | -1.078 | -3.87 | 5.57838 | -2.638 | -3.7 | 63 | 80 | -1.075 | 9 | 9 | 0 | 0 | strand | 3.36666666666667 | 8.8 | 0.0024435820037372 | 28.4570212765957 | 28.4570177059942 | 28.4308865607855 | 107.057952768928 | 22 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 0 | -3 | 0 | -1 | -2 | 6 | 0 | 4 | 6 | -0.273049645390071 | -1 | 0.203176742254824 | -0.449786871270247 | -0.968586387434555 | 0.663157894736842 | -0.885502471169687 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.152 | -1.028 | 9:9 | 146/150 | F:V:L:I | 3.34839479820379 | 4.89069202996555e-12 | 0.484662577645081 | 6.90871330415739 | 12.0071584873314 | 83.7151686983107 | 1.4541894385859 | 5.6263316435115e-18 | 17.2497746719749 | 10.8739157094292 | 94.2522723934353 | 4.32340113554558e-25 | lineage2 | dr_mutations_pyrazinamide | SER | 0 | SAMN02628490 | SRR1173490_SRR1173844 | lineage2.2.1 | ir | Iran | pnca_p.leu4ser | A | E | LEU | LA4 | pnca_complex.pdb |
69 | L4S | L2 | PZA | L | L4 | 4 | S | NA | XDR | DM | hydrophobic | hydrophilic | non-polar | neutral | non-polar | polar | 15.328 | -1.078 | -3.87 | 5.57838 | -2.638 | -3.7 | 63 | 80 | -1.075 | 9 | 9 | 0 | 0 | strand | 3.36666666666667 | 8.8 | 0.0024435820037372 | 28.4570212765957 | 28.4570177059942 | 28.4308865607855 | 107.057952768928 | 22 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 0 | -3 | 0 | -1 | -2 | 6 | 0 | 4 | 6 | -0.273049645390071 | -1 | 0.203176742254824 | -0.449786871270247 | -0.968586387434555 | 0.663157894736842 | -0.885502471169687 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.152 | -1.028 | 9:9 | 146/150 | F:V:L:I | 3.34839479820379 | 4.89069202996555e-12 | 0.484662577645081 | 6.90871330415739 | 12.0071584873314 | 83.7151686983107 | 1.4541894385859 | 5.6263316435115e-18 | 17.2497746719749 | 10.8739157094292 | 94.2522723934353 | 4.32340113554558e-25 | lineage2 | dr_mutations_pyrazinamide | SER | 0 | SRR671789,BGI_GuangZ24 | SRR671789 | lineage2.2.1 | cn | China | pnca_p.leu4ser | A | E | LEU | LA4 | pnca_complex.pdb |
70 | L4S | L4 | PZA | L | L4 | 4 | S | 1 | Pre-XDR | DM | hydrophobic | hydrophilic | non-polar | neutral | non-polar | polar | 15.328 | -1.078 | -3.87 | 5.57838 | -2.638 | -3.7 | 63 | 80 | -1.075 | 9 | 9 | 0 | 0 | strand | 3.36666666666667 | 8.8 | 0.0024435820037372 | 28.4570212765957 | 28.4570177059942 | 28.4308865607855 | 107.057952768928 | 22 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 0 | -3 | 0 | -1 | -2 | 6 | 0 | 4 | 6 | -0.273049645390071 | -1 | 0.203176742254824 | -0.449786871270247 | -0.968586387434555 | 0.663157894736842 | -0.885502471169687 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.152 | -1.028 | 9:9 | 146/150 | F:V:L:I | 3.34839479820379 | 4.89069202996555e-12 | 0.484662577645081 | 6.90871330415739 | 12.0071584873314 | 83.7151686983107 | 1.4541894385859 | 5.6263316435115e-18 | 17.2497746719749 | 10.8739157094292 | 94.2522723934353 | 4.32340113554558e-25 | lineage4 | dr_mutations_pyrazinamide | SER | 0 | ERR2514395 | ERR2514395 | lineage4 | gb | UK | pnca_p.leu4ser | A | E | LEU | LA4 | pnca_complex.pdb |
71 | L4S | L2 | PZA | L | L4 | 4 | S | 1 | MDR | DM | hydrophobic | hydrophilic | non-polar | neutral | non-polar | polar | 15.328 | -1.078 | -3.87 | 5.57838 | -2.638 | -3.7 | 63 | 80 | -1.075 | 9 | 9 | 0 | 0 | strand | 3.36666666666667 | 8.8 | 0.0024435820037372 | 28.4570212765957 | 28.4570177059942 | 28.4308865607855 | 107.057952768928 | 22 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 0 | -3 | 0 | -1 | -2 | 6 | 0 | 4 | 6 | -0.273049645390071 | -1 | 0.203176742254824 | -0.449786871270247 | -0.968586387434555 | 0.663157894736842 | -0.885502471169687 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.152 | -1.028 | 9:9 | 146/150 | F:V:L:I | 3.34839479820379 | 4.89069202996555e-12 | 0.484662577645081 | 6.90871330415739 | 12.0071584873314 | 83.7151686983107 | 1.4541894385859 | 5.6263316435115e-18 | 17.2497746719749 | 10.8739157094292 | 94.2522723934353 | 4.32340113554558e-25 | lineage2 | dr_mutations_pyrazinamide | SER | 0 | ERR2516822 | ERR2516822 | lineage2.2.1 | gb | UK | pnca_p.leu4ser | A | E | LEU | LA4 | pnca_complex.pdb |
72 | L4S | L2 | PZA | L | L4 | 4 | S | 1 | MDR | DM | hydrophobic | hydrophilic | non-polar | neutral | non-polar | polar | 15.328 | -1.078 | -3.87 | 5.57838 | -2.638 | -3.7 | 63 | 80 | -1.075 | 9 | 9 | 0 | 0 | strand | 3.36666666666667 | 8.8 | 0.0024435820037372 | 28.4570212765957 | 28.4570177059942 | 28.4308865607855 | 107.057952768928 | 22 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 0 | -3 | 0 | -1 | -2 | 6 | 0 | 4 | 6 | -0.273049645390071 | -1 | 0.203176742254824 | -0.449786871270247 | -0.968586387434555 | 0.663157894736842 | -0.885502471169687 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.152 | -1.028 | 9:9 | 146/150 | F:V:L:I | 3.34839479820379 | 4.89069202996555e-12 | 0.484662577645081 | 6.90871330415739 | 12.0071584873314 | 83.7151686983107 | 1.4541894385859 | 5.6263316435115e-18 | 17.2497746719749 | 10.8739157094292 | 94.2522723934353 | 4.32340113554558e-25 | lineage2 | dr_mutations_pyrazinamide | SER | 0 | ERR2517099 | ERR2517099 | lineage2.2.1 | gb | UK | pnca_p.leu4ser | A | E | LEU | LA4 | pnca_complex.pdb |
73 | L4S | L4 | PZA | L | L4 | 4 | S | NA | MDR | DM | hydrophobic | hydrophilic | non-polar | neutral | non-polar | polar | 15.328 | -1.078 | -3.87 | 5.57838 | -2.638 | -3.7 | 63 | 80 | -1.075 | 9 | 9 | 0 | 0 | strand | 3.36666666666667 | 8.8 | 0.0024435820037372 | 28.4570212765957 | 28.4570177059942 | 28.4308865607855 | 107.057952768928 | 22 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 0 | -3 | 0 | -1 | -2 | 6 | 0 | 4 | 6 | -0.273049645390071 | -1 | 0.203176742254824 | -0.449786871270247 | -0.968586387434555 | 0.663157894736842 | -0.885502471169687 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.152 | -1.028 | 9:9 | 146/150 | F:V:L:I | 3.34839479820379 | 4.89069202996555e-12 | 0.484662577645081 | 6.90871330415739 | 12.0071584873314 | 83.7151686983107 | 1.4541894385859 | 5.6263316435115e-18 | 17.2497746719749 | 10.8739157094292 | 94.2522723934353 | 4.32340113554558e-25 | lineage4 | dr_mutations_pyrazinamide | SER | 0 | ERR2516432 | ERR2516432 | lineage4.3.3 | nl | Netherlands | pnca_p.leu4ser | A | E | LEU | LA4 | pnca_complex.pdb |
74 | L4S | L4 | PZA | L | L4 | 4 | S | 1 | MDR | DM | hydrophobic | hydrophilic | non-polar | neutral | non-polar | polar | 15.328 | -1.078 | -3.87 | 5.57838 | -2.638 | -3.7 | 63 | 80 | -1.075 | 9 | 9 | 0 | 0 | strand | 3.36666666666667 | 8.8 | 0.0024435820037372 | 28.4570212765957 | 28.4570177059942 | 28.4308865607855 | 107.057952768928 | 22 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 0 | -3 | 0 | -1 | -2 | 6 | 0 | 4 | 6 | -0.273049645390071 | -1 | 0.203176742254824 | -0.449786871270247 | -0.968586387434555 | 0.663157894736842 | -0.885502471169687 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.152 | -1.028 | 9:9 | 146/150 | F:V:L:I | 3.34839479820379 | 4.89069202996555e-12 | 0.484662577645081 | 6.90871330415739 | 12.0071584873314 | 83.7151686983107 | 1.4541894385859 | 5.6263316435115e-18 | 17.2497746719749 | 10.8739157094292 | 94.2522723934353 | 4.32340113554558e-25 | lineage4 | dr_mutations_pyrazinamide | SER | 0 | ERR040137 | ERR040137 | lineage4.1.1.3 | ug | Uganda | pnca_p.leu4ser | A | E | LEU | LA4 | pnca_complex.pdb |
75 | L4S | L2 | PZA | L | L4 | 4 | S | 1 | MDR | DM | hydrophobic | hydrophilic | non-polar | neutral | non-polar | polar | 15.328 | -1.078 | -3.87 | 5.57838 | -2.638 | -3.7 | 63 | 80 | -1.075 | 9 | 9 | 0 | 0 | strand | 3.36666666666667 | 8.8 | 0.0024435820037372 | 28.4570212765957 | 28.4570177059942 | 28.4308865607855 | 107.057952768928 | 22 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 0 | -3 | 0 | -1 | -2 | 6 | 0 | 4 | 6 | -0.273049645390071 | -1 | 0.203176742254824 | -0.449786871270247 | -0.968586387434555 | 0.663157894736842 | -0.885502471169687 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.152 | -1.028 | 9:9 | 146/150 | F:V:L:I | 3.34839479820379 | 4.89069202996555e-12 | 0.484662577645081 | 6.90871330415739 | 12.0071584873314 | 83.7151686983107 | 1.4541894385859 | 5.6263316435115e-18 | 17.2497746719749 | 10.8739157094292 | 94.2522723934353 | 4.32340113554558e-25 | lineage2 | dr_mutations_pyrazinamide | SER | 0 | ERR2517053 | ERR2517053 | lineage2.2.1 | gb | UK | pnca_p.leu4ser | A | E | LEU | LA4 | pnca_complex.pdb |
76 | L4S | L1;L4 | PZA | L | L4 | 4 | S | NA | Pre-MDR | DM | hydrophobic | hydrophilic | non-polar | neutral | non-polar | polar | 15.328 | -1.078 | -3.87 | 5.57838 | -2.638 | -3.7 | 63 | 80 | -1.075 | 9 | 9 | 0 | 0 | strand | 3.36666666666667 | 8.8 | 0.0024435820037372 | 28.4570212765957 | 28.4570177059942 | 28.4308865607855 | 107.057952768928 | 22 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 0 | -3 | 0 | -1 | -2 | 6 | 0 | 4 | 6 | -0.273049645390071 | -1 | 0.203176742254824 | -0.449786871270247 | -0.968586387434555 | 0.663157894736842 | -0.885502471169687 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.152 | -1.028 | 9:9 | 146/150 | F:V:L:I | 3.34839479820379 | 4.89069202996555e-12 | 0.484662577645081 | 6.90871330415739 | 12.0071584873314 | 83.7151686983107 | 1.4541894385859 | 5.6263316435115e-18 | 17.2497746719749 | 10.8739157094292 | 94.2522723934353 | 4.32340113554558e-25 | lineage1;lineage4 | dr_mutations_pyrazinamide | SER | 0 | ERR2706927 | ERR2706927 | lineage4.7;lineage1.1.3 | cd | Democratic Republic of Congo | pnca_p.leu4ser | A | E | LEU | LA4 | pnca_complex.pdb |
77 | L4S | L4 | PZA | L | L4 | 4 | S | NA | MDR | DM | hydrophobic | hydrophilic | non-polar | neutral | non-polar | polar | 15.328 | -1.078 | -3.87 | 5.57838 | -2.638 | -3.7 | 63 | 80 | -1.075 | 9 | 9 | 0 | 0 | strand | 3.36666666666667 | 8.8 | 0.0024435820037372 | 28.4570212765957 | 28.4570177059942 | 28.4308865607855 | 107.057952768928 | 22 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 0 | -3 | 0 | -1 | -2 | 6 | 0 | 4 | 6 | -0.273049645390071 | -1 | 0.203176742254824 | -0.449786871270247 | -0.968586387434555 | 0.663157894736842 | -0.885502471169687 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.152 | -1.028 | 9:9 | 146/150 | F:V:L:I | 3.34839479820379 | 4.89069202996555e-12 | 0.484662577645081 | 6.90871330415739 | 12.0071584873314 | 83.7151686983107 | 1.4541894385859 | 5.6263316435115e-18 | 17.2497746719749 | 10.8739157094292 | 94.2522723934353 | 4.32340113554558e-25 | lineage4 | dr_mutations_pyrazinamide | SER | 0 | ERR751550 | ERR751550 | lineage4.3.3 | pe | | pnca_p.leu4ser | A | E | LEU | LA4 | pnca_complex.pdb |
78 | L4S | L4 | PZA | L | L4 | 4 | S | 1 | MDR | DM | hydrophobic | hydrophilic | non-polar | neutral | non-polar | polar | 15.328 | -1.078 | -3.87 | 5.57838 | -2.638 | -3.7 | 63 | 80 | -1.075 | 9 | 9 | 0 | 0 | strand | 3.36666666666667 | 8.8 | 0.0024435820037372 | 28.4570212765957 | 28.4570177059942 | 28.4308865607855 | 107.057952768928 | 22 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 0 | -3 | 0 | -1 | -2 | 6 | 0 | 4 | 6 | -0.273049645390071 | -1 | 0.203176742254824 | -0.449786871270247 | -0.968586387434555 | 0.663157894736842 | -0.885502471169687 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.152 | -1.028 | 9:9 | 146/150 | F:V:L:I | 3.34839479820379 | 4.89069202996555e-12 | 0.484662577645081 | 6.90871330415739 | 12.0071584873314 | 83.7151686983107 | 1.4541894385859 | 5.6263316435115e-18 | 17.2497746719749 | 10.8739157094292 | 94.2522723934353 | 4.32340113554558e-25 | lineage4 | dr_mutations_pyrazinamide | SER | 0 | ERR2516671 | ERR2516671 | lineage4.3.3 | nl | Netherlands | pnca_p.leu4ser | A | E | LEU | LA4 | pnca_complex.pdb |
79 | L4S | L4 | PZA | L | L4 | 4 | S | NA | Other | DM | hydrophobic | hydrophilic | non-polar | neutral | non-polar | polar | 15.328 | -1.078 | -3.87 | 5.57838 | -2.638 | -3.7 | 63 | 80 | -1.075 | 9 | 9 | 0 | 0 | strand | 3.36666666666667 | 8.8 | 0.0024435820037372 | 28.4570212765957 | 28.4570177059942 | 28.4308865607855 | 107.057952768928 | 22 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 0 | -3 | 0 | -1 | -2 | 6 | 0 | 4 | 6 | -0.273049645390071 | -1 | 0.203176742254824 | -0.449786871270247 | -0.968586387434555 | 0.663157894736842 | -0.885502471169687 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.152 | -1.028 | 9:9 | 146/150 | F:V:L:I | 3.34839479820379 | 4.89069202996555e-12 | 0.484662577645081 | 6.90871330415739 | 12.0071584873314 | 83.7151686983107 | 1.4541894385859 | 5.6263316435115e-18 | 17.2497746719749 | 10.8739157094292 | 94.2522723934353 | 4.32340113554558e-25 | lineage4 | dr_mutations_pyrazinamide | SER | 0 | SRR4035802 | SRR4035802 | lineage4.1.2 | za | South Africa: Kwazulu-Natal | pnca_p.leu4ser | A | E | LEU | LA4 | pnca_complex.pdb |
80 | L4S | L1 | PZA | L | L4 | 4 | S | NA | MDR | DM | hydrophobic | hydrophilic | non-polar | neutral | non-polar | polar | 15.328 | -1.078 | -3.87 | 5.57838 | -2.638 | -3.7 | 63 | 80 | -1.075 | 9 | 9 | 0 | 0 | strand | 3.36666666666667 | 8.8 | 0.0024435820037372 | 28.4570212765957 | 28.4570177059942 | 28.4308865607855 | 107.057952768928 | 22 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 0 | -3 | 0 | -1 | -2 | 6 | 0 | 4 | 6 | -0.273049645390071 | -1 | 0.203176742254824 | -0.449786871270247 | -0.968586387434555 | 0.663157894736842 | -0.885502471169687 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.152 | -1.028 | 9:9 | 146/150 | F:V:L:I | 3.34839479820379 | 4.89069202996555e-12 | 0.484662577645081 | 6.90871330415739 | 12.0071584873314 | 83.7151686983107 | 1.4541894385859 | 5.6263316435115e-18 | 17.2497746719749 | 10.8739157094292 | 94.2522723934353 | 4.32340113554558e-25 | lineage1 | dr_mutations_pyrazinamide | SER | 0 | SRR6397957 | SRR6397957 | lineage1.2.1 | ca | Canada | pnca_p.leu4ser | A | E | LEU | LA4 | pnca_complex.pdb |
81 | L4S | L2 | PZA | L | L4 | 4 | S | 0 | MDR | DM | hydrophobic | hydrophilic | non-polar | neutral | non-polar | polar | 15.328 | -1.078 | -3.87 | 5.57838 | -2.638 | -3.7 | 63 | 80 | -1.075 | 9 | 9 | 0 | 0 | strand | 3.36666666666667 | 8.8 | 0.0024435820037372 | 28.4570212765957 | 28.4570177059942 | 28.4308865607855 | 107.057952768928 | 22 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 0 | -3 | 0 | -1 | -2 | 6 | 0 | 4 | 6 | -0.273049645390071 | -1 | 0.203176742254824 | -0.449786871270247 | -0.968586387434555 | 0.663157894736842 | -0.885502471169687 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.152 | -1.028 | 9:9 | 146/150 | F:V:L:I | 3.34839479820379 | 4.89069202996555e-12 | 0.484662577645081 | 6.90871330415739 | 12.0071584873314 | 83.7151686983107 | 1.4541894385859 | 5.6263316435115e-18 | 17.2497746719749 | 10.8739157094292 | 94.2522723934353 | 4.32340113554558e-25 | lineage2 | dr_mutations_pyrazinamide | SER | 0 | ERR2516916 | ERR2516916 | lineage2.2.1 | gb | UK | pnca_p.leu4ser | A | E | LEU | LA4 | pnca_complex.pdb |
82 | L4S | L4 | PZA | L | L4 | 4 | S | NA | MDR | DM | hydrophobic | hydrophilic | non-polar | neutral | non-polar | polar | 15.328 | -1.078 | -3.87 | 5.57838 | -2.638 | -3.7 | 63 | 80 | -1.075 | 9 | 9 | 0 | 0 | strand | 3.36666666666667 | 8.8 | 0.0024435820037372 | 28.4570212765957 | 28.4570177059942 | 28.4308865607855 | 107.057952768928 | 22 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 0 | -3 | 0 | -1 | -2 | 6 | 0 | 4 | 6 | -0.273049645390071 | -1 | 0.203176742254824 | -0.449786871270247 | -0.968586387434555 | 0.663157894736842 | -0.885502471169687 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.152 | -1.028 | 9:9 | 146/150 | F:V:L:I | 3.34839479820379 | 4.89069202996555e-12 | 0.484662577645081 | 6.90871330415739 | 12.0071584873314 | 83.7151686983107 | 1.4541894385859 | 5.6263316435115e-18 | 17.2497746719749 | 10.8739157094292 | 94.2522723934353 | 4.32340113554558e-25 | lineage4 | dr_mutations_pyrazinamide | SER | 0 | ERR3256132 | ERR3256132 | lineage4.5 | ph | Philippines | pnca_p.leu4ser | A | E | LEU | LA4 | pnca_complex.pdb |
83 | L4S | L2 | PZA | L | L4 | 4 | S | NA | MDR | DM | hydrophobic | hydrophilic | non-polar | neutral | non-polar | polar | 15.328 | -1.078 | -3.87 | 5.57838 | -2.638 | -3.7 | 63 | 80 | -1.075 | 9 | 9 | 0 | 0 | strand | 3.36666666666667 | 8.8 | 0.0024435820037372 | 28.4570212765957 | 28.4570177059942 | 28.4308865607855 | 107.057952768928 | 22 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 0 | -3 | 0 | -1 | -2 | 6 | 0 | 4 | 6 | -0.273049645390071 | -1 | 0.203176742254824 | -0.449786871270247 | -0.968586387434555 | 0.663157894736842 | -0.885502471169687 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.152 | -1.028 | 9:9 | 146/150 | F:V:L:I | 3.34839479820379 | 4.89069202996555e-12 | 0.484662577645081 | 6.90871330415739 | 12.0071584873314 | 83.7151686983107 | 1.4541894385859 | 5.6263316435115e-18 | 17.2497746719749 | 10.8739157094292 | 94.2522723934353 | 4.32340113554558e-25 | lineage2 | dr_mutations_pyrazinamide | SER | 0 | SAMN02414900 | SRR1163039_SRR1163448_SRR1146378_SRR1144756 | lineage2.2.1 | se | Sweden | pnca_p.leu4ser | A | E | LEU | LA4 | pnca_complex.pdb |
84 | L4S | L2 | PZA | L | L4 | 4 | S | NA | XDR | DM | hydrophobic | hydrophilic | non-polar | neutral | non-polar | polar | 15.328 | -1.078 | -3.87 | 5.57838 | -2.638 | -3.7 | 63 | 80 | -1.075 | 9 | 9 | 0 | 0 | strand | 3.36666666666667 | 8.8 | 0.0024435820037372 | 28.4570212765957 | 28.4570177059942 | 28.4308865607855 | 107.057952768928 | 22 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 0 | -3 | 0 | -1 | -2 | 6 | 0 | 4 | 6 | -0.273049645390071 | -1 | 0.203176742254824 | -0.449786871270247 | -0.968586387434555 | 0.663157894736842 | -0.885502471169687 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.152 | -1.028 | 9:9 | 146/150 | F:V:L:I | 3.34839479820379 | 4.89069202996555e-12 | 0.484662577645081 | 6.90871330415739 | 12.0071584873314 | 83.7151686983107 | 1.4541894385859 | 5.6263316435115e-18 | 17.2497746719749 | 10.8739157094292 | 94.2522723934353 | 4.32340113554558e-25 | lineage2 | dr_mutations_pyrazinamide | SER | 0 | SRR671863,BGI_GuangZ0008 | SRR671863 | lineage2.2.1 | cn | China | pnca_p.leu4ser | A | E | LEU | LA4 | pnca_complex.pdb |
85 | L4S | L4 | PZA | L | L4 | 4 | S | NA | MDR | DM | hydrophobic | hydrophilic | non-polar | neutral | non-polar | polar | 15.328 | -1.078 | -3.87 | 5.57838 | -2.638 | -3.7 | 63 | 80 | -1.075 | 9 | 9 | 0 | 0 | strand | 3.36666666666667 | 8.8 | 0.0024435820037372 | 28.4570212765957 | 28.4570177059942 | 28.4308865607855 | 107.057952768928 | 22 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 0 | -3 | 0 | -1 | -2 | 6 | 0 | 4 | 6 | -0.273049645390071 | -1 | 0.203176742254824 | -0.449786871270247 | -0.968586387434555 | 0.663157894736842 | -0.885502471169687 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.152 | -1.028 | 9:9 | 146/150 | F:V:L:I | 3.34839479820379 | 4.89069202996555e-12 | 0.484662577645081 | 6.90871330415739 | 12.0071584873314 | 83.7151686983107 | 1.4541894385859 | 5.6263316435115e-18 | 17.2497746719749 | 10.8739157094292 | 94.2522723934353 | 4.32340113554558e-25 | lineage4 | dr_mutations_pyrazinamide | SER | 0 | ERR1193648 | ERR1193648 | lineage4.3.3 | so | Somalia | pnca_p.leu4ser | A | E | LEU | LA4 | pnca_complex.pdb |
86 | L4S | L2 | PZA | L | L4 | 4 | S | 1 | MDR | DM | hydrophobic | hydrophilic | non-polar | neutral | non-polar | polar | 15.328 | -1.078 | -3.87 | 5.57838 | -2.638 | -3.7 | 63 | 80 | -1.075 | 9 | 9 | 0 | 0 | strand | 3.36666666666667 | 8.8 | 0.0024435820037372 | 28.4570212765957 | 28.4570177059942 | 28.4308865607855 | 107.057952768928 | 22 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 0 | -3 | 0 | -1 | -2 | 6 | 0 | 4 | 6 | -0.273049645390071 | -1 | 0.203176742254824 | -0.449786871270247 | -0.968586387434555 | 0.663157894736842 | -0.885502471169687 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.152 | -1.028 | 9:9 | 146/150 | F:V:L:I | 3.34839479820379 | 4.89069202996555e-12 | 0.484662577645081 | 6.90871330415739 | 12.0071584873314 | 83.7151686983107 | 1.4541894385859 | 5.6263316435115e-18 | 17.2497746719749 | 10.8739157094292 | 94.2522723934353 | 4.32340113554558e-25 | lineage2 | dr_mutations_pyrazinamide | SER | 0 | SRR2100306,SAMN03647479 | SRR2100306 | lineage2.2.1 | | | pnca_p.leu4ser | A | E | LEU | LA4 | pnca_complex.pdb |
87 | L4S | L4 | PZA | L | L4 | 4 | S | NA | MDR | DM | hydrophobic | hydrophilic | non-polar | neutral | non-polar | polar | 15.328 | -1.078 | -3.87 | 5.57838 | -2.638 | -3.7 | 63 | 80 | -1.075 | 9 | 9 | 0 | 0 | strand | 3.36666666666667 | 8.8 | 0.0024435820037372 | 28.4570212765957 | 28.4570177059942 | 28.4308865607855 | 107.057952768928 | 22 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 0 | -3 | 0 | -1 | -2 | 6 | 0 | 4 | 6 | -0.273049645390071 | -1 | 0.203176742254824 | -0.449786871270247 | -0.968586387434555 | 0.663157894736842 | -0.885502471169687 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.152 | -1.028 | 9:9 | 146/150 | F:V:L:I | 3.34839479820379 | 4.89069202996555e-12 | 0.484662577645081 | 6.90871330415739 | 12.0071584873314 | 83.7151686983107 | 1.4541894385859 | 5.6263316435115e-18 | 17.2497746719749 | 10.8739157094292 | 94.2522723934353 | 4.32340113554558e-25 | lineage4 | dr_mutations_pyrazinamide | SER | 0 | SRR7517813 | SRR7517813 | lineage4.3.3 | pe | Peru | pnca_p.leu4ser | A | E | LEU | LA4 | pnca_complex.pdb |
88 | L4S | L4 | PZA | L | L4 | 4 | S | 0 | MDR | DM | hydrophobic | hydrophilic | non-polar | neutral | non-polar | polar | 15.328 | -1.078 | -3.87 | 5.57838 | -2.638 | -3.7 | 63 | 80 | -1.075 | 9 | 9 | 0 | 0 | strand | 3.36666666666667 | 8.8 | 0.0024435820037372 | 28.4570212765957 | 28.4570177059942 | 28.4308865607855 | 107.057952768928 | 22 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 0 | -3 | 0 | -1 | -2 | 6 | 0 | 4 | 6 | -0.273049645390071 | -1 | 0.203176742254824 | -0.449786871270247 | -0.968586387434555 | 0.663157894736842 | -0.885502471169687 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.152 | -1.028 | 9:9 | 146/150 | F:V:L:I | 3.34839479820379 | 4.89069202996555e-12 | 0.484662577645081 | 6.90871330415739 | 12.0071584873314 | 83.7151686983107 | 1.4541894385859 | 5.6263316435115e-18 | 17.2497746719749 | 10.8739157094292 | 94.2522723934353 | 4.32340113554558e-25 | lineage4 | dr_mutations_pyrazinamide | SER | 0 | ERR2516552 | ERR2516552 | lineage4.3.3 | pe | Peru | pnca_p.leu4ser | A | E | LEU | LA4 | pnca_complex.pdb |
89 | L4S | L2 | PZA | L | L4 | 4 | S | 1 | MDR | DM | hydrophobic | hydrophilic | non-polar | neutral | non-polar | polar | 15.328 | -1.078 | -3.87 | 5.57838 | -2.638 | -3.7 | 63 | 80 | -1.075 | 9 | 9 | 0 | 0 | strand | 3.36666666666667 | 8.8 | 0.0024435820037372 | 28.4570212765957 | 28.4570177059942 | 28.4308865607855 | 107.057952768928 | 22 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 0 | -3 | 0 | -1 | -2 | 6 | 0 | 4 | 6 | -0.273049645390071 | -1 | 0.203176742254824 | -0.449786871270247 | -0.968586387434555 | 0.663157894736842 | -0.885502471169687 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.152 | -1.028 | 9:9 | 146/150 | F:V:L:I | 3.34839479820379 | 4.89069202996555e-12 | 0.484662577645081 | 6.90871330415739 | 12.0071584873314 | 83.7151686983107 | 1.4541894385859 | 5.6263316435115e-18 | 17.2497746719749 | 10.8739157094292 | 94.2522723934353 | 4.32340113554558e-25 | lineage2 | dr_mutations_pyrazinamide | SER | 0 | ERR2516882 | ERR2516882 | lineage2.2.1 | gb | UK | pnca_p.leu4ser | A | E | LEU | LA4 | pnca_complex.pdb |
90 | L4S | L4 | PZA | L | L4 | 4 | S | 1 | MDR | DM | hydrophobic | hydrophilic | non-polar | neutral | non-polar | polar | 15.328 | -1.078 | -3.87 | 5.57838 | -2.638 | -3.7 | 63 | 80 | -1.075 | 9 | 9 | 0 | 0 | strand | 3.36666666666667 | 8.8 | 0.0024435820037372 | 28.4570212765957 | 28.4570177059942 | 28.4308865607855 | 107.057952768928 | 22 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 0 | -3 | 0 | -1 | -2 | 6 | 0 | 4 | 6 | -0.273049645390071 | -1 | 0.203176742254824 | -0.449786871270247 | -0.968586387434555 | 0.663157894736842 | -0.885502471169687 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.152 | -1.028 | 9:9 | 146/150 | F:V:L:I | 3.34839479820379 | 4.89069202996555e-12 | 0.484662577645081 | 6.90871330415739 | 12.0071584873314 | 83.7151686983107 | 1.4541894385859 | 5.6263316435115e-18 | 17.2497746719749 | 10.8739157094292 | 94.2522723934353 | 4.32340113554558e-25 | lineage4 | dr_mutations_pyrazinamide | SER | 0 | ERR2516638 | ERR2516638 | lineage4.3.3 | nl | Netherlands | pnca_p.leu4ser | A | E | LEU | LA4 | pnca_complex.pdb |
91 | L4S | L2 | PZA | L | L4 | 4 | S | 1 | MDR | DM | hydrophobic | hydrophilic | non-polar | neutral | non-polar | polar | 15.328 | -1.078 | -3.87 | 5.57838 | -2.638 | -3.7 | 63 | 80 | -1.075 | 9 | 9 | 0 | 0 | strand | 3.36666666666667 | 8.8 | 0.0024435820037372 | 28.4570212765957 | 28.4570177059942 | 28.4308865607855 | 107.057952768928 | 22 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 0 | -3 | 0 | -1 | -2 | 6 | 0 | 4 | 6 | -0.273049645390071 | -1 | 0.203176742254824 | -0.449786871270247 | -0.968586387434555 | 0.663157894736842 | -0.885502471169687 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.152 | -1.028 | 9:9 | 146/150 | F:V:L:I | 3.34839479820379 | 4.89069202996555e-12 | 0.484662577645081 | 6.90871330415739 | 12.0071584873314 | 83.7151686983107 | 1.4541894385859 | 5.6263316435115e-18 | 17.2497746719749 | 10.8739157094292 | 94.2522723934353 | 4.32340113554558e-25 | lineage2 | dr_mutations_pyrazinamide | SER | 0 | ERR2513835 | ERR2513835 | lineage2.2.1 | gb | UK | pnca_p.leu4ser | A | E | LEU | LA4 | pnca_complex.pdb |
92 | L4S | L4 | PZA | L | L4 | 4 | S | NA | MDR | DM | hydrophobic | hydrophilic | non-polar | neutral | non-polar | polar | 15.328 | -1.078 | -3.87 | 5.57838 | -2.638 | -3.7 | 63 | 80 | -1.075 | 9 | 9 | 0 | 0 | strand | 3.36666666666667 | 8.8 | 0.0024435820037372 | 28.4570212765957 | 28.4570177059942 | 28.4308865607855 | 107.057952768928 | 22 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 0 | -3 | 0 | -1 | -2 | 6 | 0 | 4 | 6 | -0.273049645390071 | -1 | 0.203176742254824 | -0.449786871270247 | -0.968586387434555 | 0.663157894736842 | -0.885502471169687 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.152 | -1.028 | 9:9 | 146/150 | F:V:L:I | 3.34839479820379 | 4.89069202996555e-12 | 0.484662577645081 | 6.90871330415739 | 12.0071584873314 | 83.7151686983107 | 1.4541894385859 | 5.6263316435115e-18 | 17.2497746719749 | 10.8739157094292 | 94.2522723934353 | 4.32340113554558e-25 | lineage4 | dr_mutations_pyrazinamide | SER | 0 | ERR2707005 | ERR2707005 | lineage4.7 | cd | Democratic Republic of Congo | pnca_p.leu4ser | A | E | LEU | LA4 | pnca_complex.pdb |
93 | L4S | L2 | PZA | L | L4 | 4 | S | 1 | Pre-XDR | DM | hydrophobic | hydrophilic | non-polar | neutral | non-polar | polar | 15.328 | -1.078 | -3.87 | 5.57838 | -2.638 | -3.7 | 63 | 80 | -1.075 | 9 | 9 | 0 | 0 | strand | 3.36666666666667 | 8.8 | 0.0024435820037372 | 28.4570212765957 | 28.4570177059942 | 28.4308865607855 | 107.057952768928 | 22 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 0 | -3 | 0 | -1 | -2 | 6 | 0 | 4 | 6 | -0.273049645390071 | -1 | 0.203176742254824 | -0.449786871270247 | -0.968586387434555 | 0.663157894736842 | -0.885502471169687 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.152 | -1.028 | 9:9 | 146/150 | F:V:L:I | 3.34839479820379 | 4.89069202996555e-12 | 0.484662577645081 | 6.90871330415739 | 12.0071584873314 | 83.7151686983107 | 1.4541894385859 | 5.6263316435115e-18 | 17.2497746719749 | 10.8739157094292 | 94.2522723934353 | 4.32340113554558e-25 | lineage2 | dr_mutations_pyrazinamide | SER | 0 | ERS2592754 | ERR2677405 | lineage2.2.1 | de | Germany | pnca_p.leu4ser | A | E | LEU | LA4 | pnca_complex.pdb |
94 | L4S | L4 | PZA | L | L4 | 4 | S | NA | Pre-XDR | DM | hydrophobic | hydrophilic | non-polar | neutral | non-polar | polar | 15.328 | -1.078 | -3.87 | 5.57838 | -2.638 | -3.7 | 63 | 80 | -1.075 | 9 | 9 | 0 | 0 | strand | 3.36666666666667 | 8.8 | 0.0024435820037372 | 28.4570212765957 | 28.4570177059942 | 28.4308865607855 | 107.057952768928 | 22 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 0 | -3 | 0 | -1 | -2 | 6 | 0 | 4 | 6 | -0.273049645390071 | -1 | 0.203176742254824 | -0.449786871270247 | -0.968586387434555 | 0.663157894736842 | -0.885502471169687 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.152 | -1.028 | 9:9 | 146/150 | F:V:L:I | 3.34839479820379 | 4.89069202996555e-12 | 0.484662577645081 | 6.90871330415739 | 12.0071584873314 | 83.7151686983107 | 1.4541894385859 | 5.6263316435115e-18 | 17.2497746719749 | 10.8739157094292 | 94.2522723934353 | 4.32340113554558e-25 | lineage4 | dr_mutations_pyrazinamide | SER | 0 | SAMN07236257,SRR5710013 | SRR5710013 | lineage4.4.2 | th | Thailand | pnca_p.leu4ser | A | E | LEU | LA4 | pnca_complex.pdb |
95 | L4S | L2 | PZA | L | L4 | 4 | S | 1 | MDR | DM | hydrophobic | hydrophilic | non-polar | neutral | non-polar | polar | 15.328 | -1.078 | -3.87 | 5.57838 | -2.638 | -3.7 | 63 | 80 | -1.075 | 9 | 9 | 0 | 0 | strand | 3.36666666666667 | 8.8 | 0.0024435820037372 | 28.4570212765957 | 28.4570177059942 | 28.4308865607855 | 107.057952768928 | 22 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 0 | -3 | 0 | -1 | -2 | 6 | 0 | 4 | 6 | -0.273049645390071 | -1 | 0.203176742254824 | -0.449786871270247 | -0.968586387434555 | 0.663157894736842 | -0.885502471169687 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.152 | -1.028 | 9:9 | 146/150 | F:V:L:I | 3.34839479820379 | 4.89069202996555e-12 | 0.484662577645081 | 6.90871330415739 | 12.0071584873314 | 83.7151686983107 | 1.4541894385859 | 5.6263316435115e-18 | 17.2497746719749 | 10.8739157094292 | 94.2522723934353 | 4.32340113554558e-25 | lineage2 | dr_mutations_pyrazinamide | SER | 0 | SAMN03647142 | SRR2099969 | lineage2.2.1 | | | pnca_p.leu4ser | A | E | LEU | LA4 | pnca_complex.pdb |
96 | L4S | L2 | PZA | L | L4 | 4 | S | 1 | MDR | DM | hydrophobic | hydrophilic | non-polar | neutral | non-polar | polar | 15.328 | -1.078 | -3.87 | 5.57838 | -2.638 | -3.7 | 63 | 80 | -1.075 | 9 | 9 | 0 | 0 | strand | 3.36666666666667 | 8.8 | 0.0024435820037372 | 28.4570212765957 | 28.4570177059942 | 28.4308865607855 | 107.057952768928 | 22 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 0 | -3 | 0 | -1 | -2 | 6 | 0 | 4 | 6 | -0.273049645390071 | -1 | 0.203176742254824 | -0.449786871270247 | -0.968586387434555 | 0.663157894736842 | -0.885502471169687 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.152 | -1.028 | 9:9 | 146/150 | F:V:L:I | 3.34839479820379 | 4.89069202996555e-12 | 0.484662577645081 | 6.90871330415739 | 12.0071584873314 | 83.7151686983107 | 1.4541894385859 | 5.6263316435115e-18 | 17.2497746719749 | 10.8739157094292 | 94.2522723934353 | 4.32340113554558e-25 | lineage2 | dr_mutations_pyrazinamide | SER | 0 | ERR2516979 | ERR2516979 | lineage2.2.1 | gb | UK | pnca_p.leu4ser | A | E | LEU | LA4 | pnca_complex.pdb |
97 | L4S | L2 | PZA | L | L4 | 4 | S | 1 | MDR | DM | hydrophobic | hydrophilic | non-polar | neutral | non-polar | polar | 15.328 | -1.078 | -3.87 | 5.57838 | -2.638 | -3.7 | 63 | 80 | -1.075 | 9 | 9 | 0 | 0 | strand | 3.36666666666667 | 8.8 | 0.0024435820037372 | 28.4570212765957 | 28.4570177059942 | 28.4308865607855 | 107.057952768928 | 22 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 0 | -3 | 0 | -1 | -2 | 6 | 0 | 4 | 6 | -0.273049645390071 | -1 | 0.203176742254824 | -0.449786871270247 | -0.968586387434555 | 0.663157894736842 | -0.885502471169687 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.152 | -1.028 | 9:9 | 146/150 | F:V:L:I | 3.34839479820379 | 4.89069202996555e-12 | 0.484662577645081 | 6.90871330415739 | 12.0071584873314 | 83.7151686983107 | 1.4541894385859 | 5.6263316435115e-18 | 17.2497746719749 | 10.8739157094292 | 94.2522723934353 | 4.32340113554558e-25 | lineage2 | dr_mutations_pyrazinamide | SER | 0 | ERR2516927 | ERR2516927 | lineage2.2.1 | gb | UK | pnca_p.leu4ser | A | E | LEU | LA4 | pnca_complex.pdb |
98 | L4S | L2 | PZA | L | L4 | 4 | S | NA | MDR | DM | hydrophobic | hydrophilic | non-polar | neutral | non-polar | polar | 15.328 | -1.078 | -3.87 | 5.57838 | -2.638 | -3.7 | 63 | 80 | -1.075 | 9 | 9 | 0 | 0 | strand | 3.36666666666667 | 8.8 | 0.0024435820037372 | 28.4570212765957 | 28.4570177059942 | 28.4308865607855 | 107.057952768928 | 22 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 0 | -3 | 0 | -1 | -2 | 6 | 0 | 4 | 6 | -0.273049645390071 | -1 | 0.203176742254824 | -0.449786871270247 | -0.968586387434555 | 0.663157894736842 | -0.885502471169687 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.152 | -1.028 | 9:9 | 146/150 | F:V:L:I | 3.34839479820379 | 4.89069202996555e-12 | 0.484662577645081 | 6.90871330415739 | 12.0071584873314 | 83.7151686983107 | 1.4541894385859 | 5.6263316435115e-18 | 17.2497746719749 | 10.8739157094292 | 94.2522723934353 | 4.32340113554558e-25 | lineage2 | dr_mutations_pyrazinamide | SER | 0 | SRR6397408 | SRR6397408 | lineage2.2.1.1 | ca | Canada | pnca_p.leu4ser | A | E | LEU | LA4 | pnca_complex.pdb |
99 | L4S | L4 | PZA | L | L4 | 4 | S | 1 | MDR | DM | hydrophobic | hydrophilic | non-polar | neutral | non-polar | polar | 15.328 | -1.078 | -3.87 | 5.57838 | -2.638 | -3.7 | 63 | 80 | -1.075 | 9 | 9 | 0 | 0 | strand | 3.36666666666667 | 8.8 | 0.0024435820037372 | 28.4570212765957 | 28.4570177059942 | 28.4308865607855 | 107.057952768928 | 22 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 0 | -3 | 0 | -1 | -2 | 6 | 0 | 4 | 6 | -0.273049645390071 | -1 | 0.203176742254824 | -0.449786871270247 | -0.968586387434555 | 0.663157894736842 | -0.885502471169687 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.152 | -1.028 | 9:9 | 146/150 | F:V:L:I | 3.34839479820379 | 4.89069202996555e-12 | 0.484662577645081 | 6.90871330415739 | 12.0071584873314 | 83.7151686983107 | 1.4541894385859 | 5.6263316435115e-18 | 17.2497746719749 | 10.8739157094292 | 94.2522723934353 | 4.32340113554558e-25 | lineage4 | dr_mutations_pyrazinamide | SER | 0 | ERS2592806 | ERR2677462 | lineage4.2.2.1 | de | Germany | pnca_p.leu4ser | A | E | LEU | LA4 | pnca_complex.pdb |
100 | L4V | L6 | PZA | L | L4 | 4 | V | NA | MDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 15.328 | -2.828 | -1.717 | 1.19624 | -1.68 | -1.95 | 22 | 63 | -1.075 | 9 | 9 | 0 | 0 | strand | 3.36666666666667 | 8.8 | NA | NA | NA | NA | NA | 22 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -3 | 0 | -1 | -2 | 2 | 0 | 0 | 0 | -0.716312056737589 | -0.443669250645995 | 0.043569664697441 | -0.286445012787724 | -0.510471204188482 | 0.231578947368421 | -0.885502471169687 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.152 | -1.028 | 9:9 | 146/150 | F:V:L:I | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | lineage6 | other_mutations_pyrazinamide | VAL | 0 | ERR1215461 | ERR1215461 | lineage6 | gh | Ghana | pnca_p.leu4val | A | E | LEU | LA4 | pnca_complex.pdb |
101 | L4W | L2 | PZA | L | L4 | 4 | W | NA | Pre-XDR | DM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 15.328 | -2.216 | -2.169 | 1.63111 | -2.168 | -1.93 | 70 | 85 | -1.075 | 9 | 9 | 0 | 0 | strand | 3.36666666666667 | 8.8 | 0.0012217910018686 | 22.7551797040169 | 22.7551786098964 | 22.7463684762183 | 46.6274188614457 | -46 | 6 | 0 | 0 | 6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -15 | 0 | -7 | -8 | 0 | 0 | -16 | 2 | -0.5612968591692 | -0.56046511627907 | 0.0594085766941776 | -0.369650468883205 | -0.505235602094241 | 0.736842105263158 | -0.885502471169687 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.152 | -1.028 | 9:9 | 146/150 | F:V:L:I | 3.12479275069714 | 9.15103299018708e-07 | 0.636534850451638 | 4.90906782005734 | 7.42096527532349 | 98.7712876576624 | 1.35708026960092 | 7.15795820641824e-09 | 8.14521084167875 | 6.3414443600848 | 123.179124931302 | 8.58505795592483e-12 | lineage2 | dr_mutations_pyrazinamide | TRP | 0 | ERR3275831 | ERR3275831 | lineage2.2.1 | nl | Netherlands | pnca_p.leu4trp | A | E | LEU | LA4 | pnca_complex.pdb |
102 | L4W | L1 | PZA | L | L4 | 4 | W | 0 | MDR | DM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 15.328 | -2.216 | -2.169 | 1.63111 | -2.168 | -1.93 | 70 | 85 | -1.075 | 9 | 9 | 0 | 0 | strand | 3.36666666666667 | 8.8 | 0.0012217910018686 | 22.7551797040169 | 22.7551786098964 | 22.7463684762183 | 46.6274188614457 | -46 | 6 | 0 | 0 | 6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -15 | 0 | -7 | -8 | 0 | 0 | -16 | 2 | -0.5612968591692 | -0.56046511627907 | 0.0594085766941776 | -0.369650468883205 | -0.505235602094241 | 0.736842105263158 | -0.885502471169687 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.152 | -1.028 | 9:9 | 146/150 | F:V:L:I | 3.12479275069714 | 9.15103299018708e-07 | 0.636534850451638 | 4.90906782005734 | 7.42096527532349 | 98.7712876576624 | 1.35708026960092 | 7.15795820641824e-09 | 8.14521084167875 | 6.3414443600848 | 123.179124931302 | 8.58505795592483e-12 | lineage1 | dr_mutations_pyrazinamide | TRP | 0 | ERR2516881 | ERR2516881 | lineage1.1.3 | gb | UK | pnca_p.leu4trp | A | E | LEU | LA4 | pnca_complex.pdb |
103 | L4W | L4 | PZA | L | L4 | 4 | W | 1 | Pre-XDR | DM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 15.328 | -2.216 | -2.169 | 1.63111 | -2.168 | -1.93 | 70 | 85 | -1.075 | 9 | 9 | 0 | 0 | strand | 3.36666666666667 | 8.8 | 0.0012217910018686 | 22.7551797040169 | 22.7551786098964 | 22.7463684762183 | 46.6274188614457 | -46 | 6 | 0 | 0 | 6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -15 | 0 | -7 | -8 | 0 | 0 | -16 | 2 | -0.5612968591692 | -0.56046511627907 | 0.0594085766941776 | -0.369650468883205 | -0.505235602094241 | 0.736842105263158 | -0.885502471169687 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.152 | -1.028 | 9:9 | 146/150 | F:V:L:I | 3.12479275069714 | 9.15103299018708e-07 | 0.636534850451638 | 4.90906782005734 | 7.42096527532349 | 98.7712876576624 | 1.35708026960092 | 7.15795820641824e-09 | 8.14521084167875 | 6.3414443600848 | 123.179124931302 | 8.58505795592483e-12 | lineage4 | dr_mutations_pyrazinamide | TRP | 0 | 18710 | ERR3014623 | lineage4.1.2.1 | tn | Tunisia:Bizerte | pnca_p.leu4trp | A | E | LEU | LA4 | pnca_complex.pdb |
104 | L4W | L1 | PZA | L | L4 | 4 | W | 0 | MDR | DM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 15.328 | -2.216 | -2.169 | 1.63111 | -2.168 | -1.93 | 70 | 85 | -1.075 | 9 | 9 | 0 | 0 | strand | 3.36666666666667 | 8.8 | 0.0012217910018686 | 22.7551797040169 | 22.7551786098964 | 22.7463684762183 | 46.6274188614457 | -46 | 6 | 0 | 0 | 6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -15 | 0 | -7 | -8 | 0 | 0 | -16 | 2 | -0.5612968591692 | -0.56046511627907 | 0.0594085766941776 | -0.369650468883205 | -0.505235602094241 | 0.736842105263158 | -0.885502471169687 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.152 | -1.028 | 9:9 | 146/150 | F:V:L:I | 3.12479275069714 | 9.15103299018708e-07 | 0.636534850451638 | 4.90906782005734 | 7.42096527532349 | 98.7712876576624 | 1.35708026960092 | 7.15795820641824e-09 | 8.14521084167875 | 6.3414443600848 | 123.179124931302 | 8.58505795592483e-12 | lineage1 | dr_mutations_pyrazinamide | TRP | 0 | ERR2516763 | ERR2516763 | lineage1.1.3 | gb | UK | pnca_p.leu4trp | A | E | LEU | LA4 | pnca_complex.pdb |
105 | L4W | L4 | PZA | L | L4 | 4 | W | 1 | MDR | DM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 15.328 | -2.216 | -2.169 | 1.63111 | -2.168 | -1.93 | 70 | 85 | -1.075 | 9 | 9 | 0 | 0 | strand | 3.36666666666667 | 8.8 | 0.0012217910018686 | 22.7551797040169 | 22.7551786098964 | 22.7463684762183 | 46.6274188614457 | -46 | 6 | 0 | 0 | 6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -15 | 0 | -7 | -8 | 0 | 0 | -16 | 2 | -0.5612968591692 | -0.56046511627907 | 0.0594085766941776 | -0.369650468883205 | -0.505235602094241 | 0.736842105263158 | -0.885502471169687 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.152 | -1.028 | 9:9 | 146/150 | F:V:L:I | 3.12479275069714 | 9.15103299018708e-07 | 0.636534850451638 | 4.90906782005734 | 7.42096527532349 | 98.7712876576624 | 1.35708026960092 | 7.15795820641824e-09 | 8.14521084167875 | 6.3414443600848 | 123.179124931302 | 8.58505795592483e-12 | lineage4 | dr_mutations_pyrazinamide | TRP | 0 | 13916 | ERR3014609 | lineage4.1.2.1 | tn | Tunisia:Beja | pnca_p.leu4trp | A | E | LEU | LA4 | pnca_complex.pdb |
106 | L4W | L2 | PZA | L | L4 | 4 | W | NA | Pre-XDR | DM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 15.328 | -2.216 | -2.169 | 1.63111 | -2.168 | -1.93 | 70 | 85 | -1.075 | 9 | 9 | 0 | 0 | strand | 3.36666666666667 | 8.8 | 0.0012217910018686 | 22.7551797040169 | 22.7551786098964 | 22.7463684762183 | 46.6274188614457 | -46 | 6 | 0 | 0 | 6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -15 | 0 | -7 | -8 | 0 | 0 | -16 | 2 | -0.5612968591692 | -0.56046511627907 | 0.0594085766941776 | -0.369650468883205 | -0.505235602094241 | 0.736842105263158 | -0.885502471169687 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.152 | -1.028 | 9:9 | 146/150 | F:V:L:I | 3.12479275069714 | 9.15103299018708e-07 | 0.636534850451638 | 4.90906782005734 | 7.42096527532349 | 98.7712876576624 | 1.35708026960092 | 7.15795820641824e-09 | 8.14521084167875 | 6.3414443600848 | 123.179124931302 | 8.58505795592483e-12 | lineage2 | dr_mutations_pyrazinamide | TRP | 0 | SRS796975 | SRR1723462 | lineage2.2.1 | cn | China:Guizhou | pnca_p.leu4trp | A | E | LEU | LA4 | pnca_complex.pdb |
107 | L4W | L1 | PZA | L | L4 | 4 | W | NA | Pre-XDR | DM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 15.328 | -2.216 | -2.169 | 1.63111 | -2.168 | -1.93 | 70 | 85 | -1.075 | 9 | 9 | 0 | 0 | strand | 3.36666666666667 | 8.8 | 0.0012217910018686 | 22.7551797040169 | 22.7551786098964 | 22.7463684762183 | 46.6274188614457 | -46 | 6 | 0 | 0 | 6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -15 | 0 | -7 | -8 | 0 | 0 | -16 | 2 | -0.5612968591692 | -0.56046511627907 | 0.0594085766941776 | -0.369650468883205 | -0.505235602094241 | 0.736842105263158 | -0.885502471169687 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.152 | -1.028 | 9:9 | 146/150 | F:V:L:I | 3.12479275069714 | 9.15103299018708e-07 | 0.636534850451638 | 4.90906782005734 | 7.42096527532349 | 98.7712876576624 | 1.35708026960092 | 7.15795820641824e-09 | 8.14521084167875 | 6.3414443600848 | 123.179124931302 | 8.58505795592483e-12 | lineage1 | dr_mutations_pyrazinamide | TRP | 0 | SRR8380866 | SRR8380866 | lineage1.1.2 | in | India | pnca_p.leu4trp | A | E | LEU | LA4 | pnca_complex.pdb |
108 | L4W | L2;L4 | PZA | L | L4 | 4 | W | 1 | Pre-XDR | DM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 15.328 | -2.216 | -2.169 | 1.63111 | -2.168 | -1.93 | 70 | 85 | -1.075 | 9 | 9 | 0 | 0 | strand | 3.36666666666667 | 8.8 | 0.0012217910018686 | 22.7551797040169 | 22.7551786098964 | 22.7463684762183 | 46.6274188614457 | -46 | 6 | 0 | 0 | 6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -15 | 0 | -7 | -8 | 0 | 0 | -16 | 2 | -0.5612968591692 | -0.56046511627907 | 0.0594085766941776 | -0.369650468883205 | -0.505235602094241 | 0.736842105263158 | -0.885502471169687 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.152 | -1.028 | 9:9 | 146/150 | F:V:L:I | 3.12479275069714 | 9.15103299018708e-07 | 0.636534850451638 | 4.90906782005734 | 7.42096527532349 | 98.7712876576624 | 1.35708026960092 | 7.15795820641824e-09 | 8.14521084167875 | 6.3414443600848 | 123.179124931302 | 8.58505795592483e-12 | lineage2;lineage4 | dr_mutations_pyrazinamide | TRP | 0 | 1735M-sc-2012-02-21T11:37:09Z-1364763,ERR137271 | ERR137271 | lineage4.2.1;lineage2.2.1 | ru | Russia,Samara | pnca_p.leu4trp | A | E | LEU | LA4 | pnca_complex.pdb |
109 | L4W | L4 | PZA | L | L4 | 4 | W | 1 | MDR | DM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 15.328 | -2.216 | -2.169 | 1.63111 | -2.168 | -1.93 | 70 | 85 | -1.075 | 9 | 9 | 0 | 0 | strand | 3.36666666666667 | 8.8 | 0.0012217910018686 | 22.7551797040169 | 22.7551786098964 | 22.7463684762183 | 46.6274188614457 | -46 | 6 | 0 | 0 | 6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -15 | 0 | -7 | -8 | 0 | 0 | -16 | 2 | -0.5612968591692 | -0.56046511627907 | 0.0594085766941776 | -0.369650468883205 | -0.505235602094241 | 0.736842105263158 | -0.885502471169687 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.152 | -1.028 | 9:9 | 146/150 | F:V:L:I | 3.12479275069714 | 9.15103299018708e-07 | 0.636534850451638 | 4.90906782005734 | 7.42096527532349 | 98.7712876576624 | 1.35708026960092 | 7.15795820641824e-09 | 8.14521084167875 | 6.3414443600848 | 123.179124931302 | 8.58505795592483e-12 | lineage4 | dr_mutations_pyrazinamide | TRP | 0 | 13878 | ERR3014608 | lineage4.1.2.1 | tn | Tunisia:Bizerte | pnca_p.leu4trp | A | E | LEU | LA4 | pnca_complex.pdb |
110 | L4W | L2 | PZA | L | L4 | 4 | W | 1 | Pre-XDR | DM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 15.328 | -2.216 | -2.169 | 1.63111 | -2.168 | -1.93 | 70 | 85 | -1.075 | 9 | 9 | 0 | 0 | strand | 3.36666666666667 | 8.8 | 0.0012217910018686 | 22.7551797040169 | 22.7551786098964 | 22.7463684762183 | 46.6274188614457 | -46 | 6 | 0 | 0 | 6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -15 | 0 | -7 | -8 | 0 | 0 | -16 | 2 | -0.5612968591692 | -0.56046511627907 | 0.0594085766941776 | -0.369650468883205 | -0.505235602094241 | 0.736842105263158 | -0.885502471169687 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.152 | -1.028 | 9:9 | 146/150 | F:V:L:I | 3.12479275069714 | 9.15103299018708e-07 | 0.636534850451638 | 4.90906782005734 | 7.42096527532349 | 98.7712876576624 | 1.35708026960092 | 7.15795820641824e-09 | 8.14521084167875 | 6.3414443600848 | 123.179124931302 | 8.58505795592483e-12 | lineage2 | dr_mutations_pyrazinamide | TRP | 0 | SAMN10961363 | SRR8651607 | lineage2.2.1 | cn | China:Wenzhou | pnca_p.leu4trp | A | E | LEU | LA4 | pnca_complex.pdb |
111 | L4W | L2 | PZA | L | L4 | 4 | W | NA | MDR | DM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 15.328 | -2.216 | -2.169 | 1.63111 | -2.168 | -1.93 | 70 | 85 | -1.075 | 9 | 9 | 0 | 0 | strand | 3.36666666666667 | 8.8 | 0.0012217910018686 | 22.7551797040169 | 22.7551786098964 | 22.7463684762183 | 46.6274188614457 | -46 | 6 | 0 | 0 | 6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -15 | 0 | -7 | -8 | 0 | 0 | -16 | 2 | -0.5612968591692 | -0.56046511627907 | 0.0594085766941776 | -0.369650468883205 | -0.505235602094241 | 0.736842105263158 | -0.885502471169687 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.152 | -1.028 | 9:9 | 146/150 | F:V:L:I | 3.12479275069714 | 9.15103299018708e-07 | 0.636534850451638 | 4.90906782005734 | 7.42096527532349 | 98.7712876576624 | 1.35708026960092 | 7.15795820641824e-09 | 8.14521084167875 | 6.3414443600848 | 123.179124931302 | 8.58505795592483e-12 | lineage2 | dr_mutations_pyrazinamide | TRP | 0 | ERR137236,1477G-sc-2012-02-21T11:36:45Z-1364728 | ERR137236 | lineage2.2.1 | ru | Russia | pnca_p.leu4trp | A | E | LEU | LA4 | pnca_complex.pdb |
112 | L4W | L2 | PZA | L | L4 | 4 | W | NA | XDR | DM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 15.328 | -2.216 | -2.169 | 1.63111 | -2.168 | -1.93 | 70 | 85 | -1.075 | 9 | 9 | 0 | 0 | strand | 3.36666666666667 | 8.8 | 0.0012217910018686 | 22.7551797040169 | 22.7551786098964 | 22.7463684762183 | 46.6274188614457 | -46 | 6 | 0 | 0 | 6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -15 | 0 | -7 | -8 | 0 | 0 | -16 | 2 | -0.5612968591692 | -0.56046511627907 | 0.0594085766941776 | -0.369650468883205 | -0.505235602094241 | 0.736842105263158 | -0.885502471169687 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.152 | -1.028 | 9:9 | 146/150 | F:V:L:I | 3.12479275069714 | 9.15103299018708e-07 | 0.636534850451638 | 4.90906782005734 | 7.42096527532349 | 98.7712876576624 | 1.35708026960092 | 7.15795820641824e-09 | 8.14521084167875 | 6.3414443600848 | 123.179124931302 | 8.58505795592483e-12 | lineage2 | dr_mutations_pyrazinamide | TRP | 0 | SAMN02398703 | SRR1144796_SRR1047989 | lineage2.2.2 | kr | South Korea | pnca_p.leu4trp | A | E | LEU | LA4 | pnca_complex.pdb |
113 | L4W | L2 | PZA | L | L4 | 4 | W | 1 | XDR | DM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 15.328 | -2.216 | -2.169 | 1.63111 | -2.168 | -1.93 | 70 | 85 | -1.075 | 9 | 9 | 0 | 0 | strand | 3.36666666666667 | 8.8 | 0.0012217910018686 | 22.7551797040169 | 22.7551786098964 | 22.7463684762183 | 46.6274188614457 | -46 | 6 | 0 | 0 | 6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -15 | 0 | -7 | -8 | 0 | 0 | -16 | 2 | -0.5612968591692 | -0.56046511627907 | 0.0594085766941776 | -0.369650468883205 | -0.505235602094241 | 0.736842105263158 | -0.885502471169687 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.152 | -1.028 | 9:9 | 146/150 | F:V:L:I | 3.12479275069714 | 9.15103299018708e-07 | 0.636534850451638 | 4.90906782005734 | 7.42096527532349 | 98.7712876576624 | 1.35708026960092 | 7.15795820641824e-09 | 8.14521084167875 | 6.3414443600848 | 123.179124931302 | 8.58505795592483e-12 | lineage2 | dr_mutations_pyrazinamide | TRP | 0 | SAMN10961353 | SRR8651594 | lineage2.2.1 | cn | China:Wenzhou | pnca_p.leu4trp | A | E | LEU | LA4 | pnca_complex.pdb |
114 | L4W | L2 | PZA | L | L4 | 4 | W | 1 | Pre-XDR | DM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 15.328 | -2.216 | -2.169 | 1.63111 | -2.168 | -1.93 | 70 | 85 | -1.075 | 9 | 9 | 0 | 0 | strand | 3.36666666666667 | 8.8 | 0.0012217910018686 | 22.7551797040169 | 22.7551786098964 | 22.7463684762183 | 46.6274188614457 | -46 | 6 | 0 | 0 | 6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -15 | 0 | -7 | -8 | 0 | 0 | -16 | 2 | -0.5612968591692 | -0.56046511627907 | 0.0594085766941776 | -0.369650468883205 | -0.505235602094241 | 0.736842105263158 | -0.885502471169687 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.152 | -1.028 | 9:9 | 146/150 | F:V:L:I | 3.12479275069714 | 9.15103299018708e-07 | 0.636534850451638 | 4.90906782005734 | 7.42096527532349 | 98.7712876576624 | 1.35708026960092 | 7.15795820641824e-09 | 8.14521084167875 | 6.3414443600848 | 123.179124931302 | 8.58505795592483e-12 | lineage2 | dr_mutations_pyrazinamide | TRP | 0 | MDR_24272 | SRR6824542 | lineage2.2.1 | cn | China: Bijie City, Guizhou Province | pnca_p.leu4trp | A | E | LEU | LA4 | pnca_complex.pdb |
115 | L4W | L2 | PZA | L | L4 | 4 | W | NA | XDR | DM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 15.328 | -2.216 | -2.169 | 1.63111 | -2.168 | -1.93 | 70 | 85 | -1.075 | 9 | 9 | 0 | 0 | strand | 3.36666666666667 | 8.8 | 0.0012217910018686 | 22.7551797040169 | 22.7551786098964 | 22.7463684762183 | 46.6274188614457 | -46 | 6 | 0 | 0 | 6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -15 | 0 | -7 | -8 | 0 | 0 | -16 | 2 | -0.5612968591692 | -0.56046511627907 | 0.0594085766941776 | -0.369650468883205 | -0.505235602094241 | 0.736842105263158 | -0.885502471169687 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.152 | -1.028 | 9:9 | 146/150 | F:V:L:I | 3.12479275069714 | 9.15103299018708e-07 | 0.636534850451638 | 4.90906782005734 | 7.42096527532349 | 98.7712876576624 | 1.35708026960092 | 7.15795820641824e-09 | 8.14521084167875 | 6.3414443600848 | 123.179124931302 | 8.58505795592483e-12 | lineage2 | dr_mutations_pyrazinamide | TRP | 0 | SAMN07236540,SRR5710028 | SRR5710028 | lineage2.2.1 | th | Thailand | pnca_p.leu4trp | A | E | LEU | LA4 | pnca_complex.pdb |
116 | L4W | L2 | PZA | L | L4 | 4 | W | 1 | Pre-XDR | DM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 15.328 | -2.216 | -2.169 | 1.63111 | -2.168 | -1.93 | 70 | 85 | -1.075 | 9 | 9 | 0 | 0 | strand | 3.36666666666667 | 8.8 | 0.0012217910018686 | 22.7551797040169 | 22.7551786098964 | 22.7463684762183 | 46.6274188614457 | -46 | 6 | 0 | 0 | 6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -15 | 0 | -7 | -8 | 0 | 0 | -16 | 2 | -0.5612968591692 | -0.56046511627907 | 0.0594085766941776 | -0.369650468883205 | -0.505235602094241 | 0.736842105263158 | -0.885502471169687 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.152 | -1.028 | 9:9 | 146/150 | F:V:L:I | 3.12479275069714 | 9.15103299018708e-07 | 0.636534850451638 | 4.90906782005734 | 7.42096527532349 | 98.7712876576624 | 1.35708026960092 | 7.15795820641824e-09 | 8.14521084167875 | 6.3414443600848 | 123.179124931302 | 8.58505795592483e-12 | lineage2 | dr_mutations_pyrazinamide | TRP | 0 | SAMN10961319 | SRR8651646 | lineage2.2.1 | cn | China:Wenzhou | pnca_p.leu4trp | A | E | LEU | LA4 | pnca_complex.pdb |
117 | L4W | L4 | PZA | L | L4 | 4 | W | 1 | MDR | DM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 15.328 | -2.216 | -2.169 | 1.63111 | -2.168 | -1.93 | 70 | 85 | -1.075 | 9 | 9 | 0 | 0 | strand | 3.36666666666667 | 8.8 | 0.0012217910018686 | 22.7551797040169 | 22.7551786098964 | 22.7463684762183 | 46.6274188614457 | -46 | 6 | 0 | 0 | 6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -15 | 0 | -7 | -8 | 0 | 0 | -16 | 2 | -0.5612968591692 | -0.56046511627907 | 0.0594085766941776 | -0.369650468883205 | -0.505235602094241 | 0.736842105263158 | -0.885502471169687 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.152 | -1.028 | 9:9 | 146/150 | F:V:L:I | 3.12479275069714 | 9.15103299018708e-07 | 0.636534850451638 | 4.90906782005734 | 7.42096527532349 | 98.7712876576624 | 1.35708026960092 | 7.15795820641824e-09 | 8.14521084167875 | 6.3414443600848 | 123.179124931302 | 8.58505795592483e-12 | lineage4 | dr_mutations_pyrazinamide | TRP | 0 | 19367 | ERR3014625 | lineage4.1.2.1 | tn | Tunisia:Tunis | pnca_p.leu4trp | A | E | LEU | LA4 | pnca_complex.pdb |
118 | L4W | L2 | PZA | L | L4 | 4 | W | 1 | Pre-XDR | DM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 15.328 | -2.216 | -2.169 | 1.63111 | -2.168 | -1.93 | 70 | 85 | -1.075 | 9 | 9 | 0 | 0 | strand | 3.36666666666667 | 8.8 | 0.0012217910018686 | 22.7551797040169 | 22.7551786098964 | 22.7463684762183 | 46.6274188614457 | -46 | 6 | 0 | 0 | 6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -15 | 0 | -7 | -8 | 0 | 0 | -16 | 2 | -0.5612968591692 | -0.56046511627907 | 0.0594085766941776 | -0.369650468883205 | -0.505235602094241 | 0.736842105263158 | -0.885502471169687 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.152 | -1.028 | 9:9 | 146/150 | F:V:L:I | 3.12479275069714 | 9.15103299018708e-07 | 0.636534850451638 | 4.90906782005734 | 7.42096527532349 | 98.7712876576624 | 1.35708026960092 | 7.15795820641824e-09 | 8.14521084167875 | 6.3414443600848 | 123.179124931302 | 8.58505795592483e-12 | lineage2 | dr_mutations_pyrazinamide | TRP | 0 | SAMN10961329 | SRR8651661 | lineage2.2.1 | cn | China:Wenzhou | pnca_p.leu4trp | A | E | LEU | LA4 | pnca_complex.pdb |
119 | L4W | L3 | PZA | L | L4 | 4 | W | 1 | MDR | DM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 15.328 | -2.216 | -2.169 | 1.63111 | -2.168 | -1.93 | 70 | 85 | -1.075 | 9 | 9 | 0 | 0 | strand | 3.36666666666667 | 8.8 | 0.0012217910018686 | 22.7551797040169 | 22.7551786098964 | 22.7463684762183 | 46.6274188614457 | -46 | 6 | 0 | 0 | 6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -15 | 0 | -7 | -8 | 0 | 0 | -16 | 2 | -0.5612968591692 | -0.56046511627907 | 0.0594085766941776 | -0.369650468883205 | -0.505235602094241 | 0.736842105263158 | -0.885502471169687 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.152 | -1.028 | 9:9 | 146/150 | F:V:L:I | 3.12479275069714 | 9.15103299018708e-07 | 0.636534850451638 | 4.90906782005734 | 7.42096527532349 | 98.7712876576624 | 1.35708026960092 | 7.15795820641824e-09 | 8.14521084167875 | 6.3414443600848 | 123.179124931302 | 8.58505795592483e-12 | lineage3 | dr_mutations_pyrazinamide | TRP | 0 | ERR2510522 | ERR2510522 | lineage3 | pk | Pakistan | pnca_p.leu4trp | A | E | LEU | LA4 | pnca_complex.pdb |
120 | L4W | L4 | PZA | L | L4 | 4 | W | 1 | MDR | DM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 15.328 | -2.216 | -2.169 | 1.63111 | -2.168 | -1.93 | 70 | 85 | -1.075 | 9 | 9 | 0 | 0 | strand | 3.36666666666667 | 8.8 | 0.0012217910018686 | 22.7551797040169 | 22.7551786098964 | 22.7463684762183 | 46.6274188614457 | -46 | 6 | 0 | 0 | 6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -15 | 0 | -7 | -8 | 0 | 0 | -16 | 2 | -0.5612968591692 | -0.56046511627907 | 0.0594085766941776 | -0.369650468883205 | -0.505235602094241 | 0.736842105263158 | -0.885502471169687 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.152 | -1.028 | 9:9 | 146/150 | F:V:L:I | 3.12479275069714 | 9.15103299018708e-07 | 0.636534850451638 | 4.90906782005734 | 7.42096527532349 | 98.7712876576624 | 1.35708026960092 | 7.15795820641824e-09 | 8.14521084167875 | 6.3414443600848 | 123.179124931302 | 8.58505795592483e-12 | lineage4 | dr_mutations_pyrazinamide | TRP | 0 | 18013 | ERR3014620 | lineage4.1.2.1 | tn | Tunisia:Sousse | pnca_p.leu4trp | A | E | LEU | LA4 | pnca_complex.pdb |
121 | L4W | L1 | PZA | L | L4 | 4 | W | 0 | MDR | DM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 15.328 | -2.216 | -2.169 | 1.63111 | -2.168 | -1.93 | 70 | 85 | -1.075 | 9 | 9 | 0 | 0 | strand | 3.36666666666667 | 8.8 | 0.0012217910018686 | 22.7551797040169 | 22.7551786098964 | 22.7463684762183 | 46.6274188614457 | -46 | 6 | 0 | 0 | 6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -15 | 0 | -7 | -8 | 0 | 0 | -16 | 2 | -0.5612968591692 | -0.56046511627907 | 0.0594085766941776 | -0.369650468883205 | -0.505235602094241 | 0.736842105263158 | -0.885502471169687 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.152 | -1.028 | 9:9 | 146/150 | F:V:L:I | 3.12479275069714 | 9.15103299018708e-07 | 0.636534850451638 | 4.90906782005734 | 7.42096527532349 | 98.7712876576624 | 1.35708026960092 | 7.15795820641824e-09 | 8.14521084167875 | 6.3414443600848 | 123.179124931302 | 8.58505795592483e-12 | lineage1 | dr_mutations_pyrazinamide | TRP | 0 | ERR2516833 | ERR2516833 | lineage1.1.3 | gb | UK | pnca_p.leu4trp | A | E | LEU | LA4 | pnca_complex.pdb |
122 | L4W | L4 | PZA | L | L4 | 4 | W | 1 | MDR | DM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 15.328 | -2.216 | -2.169 | 1.63111 | -2.168 | -1.93 | 70 | 85 | -1.075 | 9 | 9 | 0 | 0 | strand | 3.36666666666667 | 8.8 | 0.0012217910018686 | 22.7551797040169 | 22.7551786098964 | 22.7463684762183 | 46.6274188614457 | -46 | 6 | 0 | 0 | 6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -15 | 0 | -7 | -8 | 0 | 0 | -16 | 2 | -0.5612968591692 | -0.56046511627907 | 0.0594085766941776 | -0.369650468883205 | -0.505235602094241 | 0.736842105263158 | -0.885502471169687 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.152 | -1.028 | 9:9 | 146/150 | F:V:L:I | 3.12479275069714 | 9.15103299018708e-07 | 0.636534850451638 | 4.90906782005734 | 7.42096527532349 | 98.7712876576624 | 1.35708026960092 | 7.15795820641824e-09 | 8.14521084167875 | 6.3414443600848 | 123.179124931302 | 8.58505795592483e-12 | lineage4 | dr_mutations_pyrazinamide | TRP | 0 | 2666 | ERR3014584 | lineage4.1.2.1 | tn | Tunisia:Sousse | pnca_p.leu4trp | A | E | LEU | LA4 | pnca_complex.pdb |
123 | L4W | L2 | PZA | L | L4 | 4 | W | NA | Pre-XDR | DM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 15.328 | -2.216 | -2.169 | 1.63111 | -2.168 | -1.93 | 70 | 85 | -1.075 | 9 | 9 | 0 | 0 | strand | 3.36666666666667 | 8.8 | 0.0012217910018686 | 22.7551797040169 | 22.7551786098964 | 22.7463684762183 | 46.6274188614457 | -46 | 6 | 0 | 0 | 6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -15 | 0 | -7 | -8 | 0 | 0 | -16 | 2 | -0.5612968591692 | -0.56046511627907 | 0.0594085766941776 | -0.369650468883205 | -0.505235602094241 | 0.736842105263158 | -0.885502471169687 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.152 | -1.028 | 9:9 | 146/150 | F:V:L:I | 3.12479275069714 | 9.15103299018708e-07 | 0.636534850451638 | 4.90906782005734 | 7.42096527532349 | 98.7712876576624 | 1.35708026960092 | 7.15795820641824e-09 | 8.14521084167875 | 6.3414443600848 | 123.179124931302 | 8.58505795592483e-12 | lineage2 | dr_mutations_pyrazinamide | TRP | 0 | SRR5710014,SAMN07236287 | SRR5710014 | lineage2.2.1 | th | Thailand | pnca_p.leu4trp | A | E | LEU | LA4 | pnca_complex.pdb |
124 | L4W | L4 | PZA | L | L4 | 4 | W | 1 | MDR | DM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 15.328 | -2.216 | -2.169 | 1.63111 | -2.168 | -1.93 | 70 | 85 | -1.075 | 9 | 9 | 0 | 0 | strand | 3.36666666666667 | 8.8 | 0.0012217910018686 | 22.7551797040169 | 22.7551786098964 | 22.7463684762183 | 46.6274188614457 | -46 | 6 | 0 | 0 | 6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -15 | 0 | -7 | -8 | 0 | 0 | -16 | 2 | -0.5612968591692 | -0.56046511627907 | 0.0594085766941776 | -0.369650468883205 | -0.505235602094241 | 0.736842105263158 | -0.885502471169687 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.152 | -1.028 | 9:9 | 146/150 | F:V:L:I | 3.12479275069714 | 9.15103299018708e-07 | 0.636534850451638 | 4.90906782005734 | 7.42096527532349 | 98.7712876576624 | 1.35708026960092 | 7.15795820641824e-09 | 8.14521084167875 | 6.3414443600848 | 123.179124931302 | 8.58505795592483e-12 | lineage4 | dr_mutations_pyrazinamide | TRP | 0 | 16260 | ERR3014615 | lineage4.1.2.1 | tn | Tunisia:Nabeul | pnca_p.leu4trp | A | E | LEU | LA4 | pnca_complex.pdb |
125 | I5S | L4 | PZA | I | I5 | 5 | S | NA | MDR | DM | hydrophobic | hydrophilic | non-polar | neutral | non-polar | polar | 11.437 | -0.778 | -3.843 | 5.83176 | -3.518 | -3.58 | 63 | 80 | -0.011 | 5 | 5 | 0 | 0 | strand | 4.26666666666667 | 12.6 | 7.18700589334483e-05 | 9.70142977291842 | 188179.92626441 | Inf | 0.763784339928386 | 30 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -4 | 0 | 0 | 0 | 0 | 0 | 4 | 0 | 2 | 2 | 0 | 0 | 4 | 0 | -0.197061803444782 | -0.993023255813954 | 0.212405393395931 | -0.599829497016198 | -0.93717277486911 | 0.663157894736842 | -0.00906095551894563 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.244 | 0.083 | 6:5 | 146/150 | G:F:I:L:V | 12.1451538387253 | 0.919026337424193 | 119.46804443616 | 0.101660271548307 | 5.0115366606943e-06 | NA | 0.986835744238421 | 0.170978870202674 | 0.767057556984365 | 0.124324963210678 | Inf | 0.382146811758261 | lineage4 | dr_mutations_pyrazinamide | SER | 0 | ERR2179669 | ERR2179669 | lineage4.4 | cn | China | pnca_p.ile5ser | A | E | ILE | IA5 | pnca_complex.pdb |
126 | I5S | L4 | PZA | I | I5 | 5 | S | NA | MDR | DM | hydrophobic | hydrophilic | non-polar | neutral | non-polar | polar | 11.437 | -0.778 | -3.843 | 5.83176 | -3.518 | -3.58 | 63 | 80 | -0.011 | 5 | 5 | 0 | 0 | strand | 4.26666666666667 | 12.6 | 7.18700589334483e-05 | 9.70142977291842 | 188179.92626441 | Inf | 0.763784339928386 | 30 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -4 | 0 | 0 | 0 | 0 | 0 | 4 | 0 | 2 | 2 | 0 | 0 | 4 | 0 | -0.197061803444782 | -0.993023255813954 | 0.212405393395931 | -0.599829497016198 | -0.93717277486911 | 0.663157894736842 | -0.00906095551894563 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.244 | 0.083 | 6:5 | 146/150 | G:F:I:L:V | 12.1451538387253 | 0.919026337424193 | 119.46804443616 | 0.101660271548307 | 5.0115366606943e-06 | NA | 0.986835744238421 | 0.170978870202674 | 0.767057556984365 | 0.124324963210678 | Inf | 0.382146811758261 | lineage4 | dr_mutations_pyrazinamide | SER | 0 | ERR502939 | ERR502939 | lineage4.4 | | | pnca_p.ile5ser | A | E | ILE | IA5 | pnca_complex.pdb |
127 | I5S | L4 | PZA | I | I5 | 5 | S | NA | MDR | DM | hydrophobic | hydrophilic | non-polar | neutral | non-polar | polar | 11.437 | -0.778 | -3.843 | 5.83176 | -3.518 | -3.58 | 63 | 80 | -0.011 | 5 | 5 | 0 | 0 | strand | 4.26666666666667 | 12.6 | 7.18700589334483e-05 | 9.70142977291842 | 188179.92626441 | Inf | 0.763784339928386 | 30 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -4 | 0 | 0 | 0 | 0 | 0 | 4 | 0 | 2 | 2 | 0 | 0 | 4 | 0 | -0.197061803444782 | -0.993023255813954 | 0.212405393395931 | -0.599829497016198 | -0.93717277486911 | 0.663157894736842 | -0.00906095551894563 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.244 | 0.083 | 6:5 | 146/150 | G:F:I:L:V | 12.1451538387253 | 0.919026337424193 | 119.46804443616 | 0.101660271548307 | 5.0115366606943e-06 | NA | 0.986835744238421 | 0.170978870202674 | 0.767057556984365 | 0.124324963210678 | Inf | 0.382146811758261 | lineage4 | dr_mutations_pyrazinamide | SER | 0 | SRS797458 | SRR1723998 | lineage4.4 | cn | China:Hunan | pnca_p.ile5ser | A | E | ILE | IA5 | pnca_complex.pdb |
128 | I5S | L2 | PZA | I | I5 | 5 | S | NA | Pre-XDR | DM | hydrophobic | hydrophilic | non-polar | neutral | non-polar | polar | 11.437 | -0.778 | -3.843 | 5.83176 | -3.518 | -3.58 | 63 | 80 | -0.011 | 5 | 5 | 0 | 0 | strand | 4.26666666666667 | 12.6 | 7.18700589334483e-05 | 9.70142977291842 | 188179.92626441 | Inf | 0.763784339928386 | 30 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -4 | 0 | 0 | 0 | 0 | 0 | 4 | 0 | 2 | 2 | 0 | 0 | 4 | 0 | -0.197061803444782 | -0.993023255813954 | 0.212405393395931 | -0.599829497016198 | -0.93717277486911 | 0.663157894736842 | -0.00906095551894563 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.244 | 0.083 | 6:5 | 146/150 | G:F:I:L:V | 12.1451538387253 | 0.919026337424193 | 119.46804443616 | 0.101660271548307 | 5.0115366606943e-06 | NA | 0.986835744238421 | 0.170978870202674 | 0.767057556984365 | 0.124324963210678 | Inf | 0.382146811758261 | lineage2 | dr_mutations_pyrazinamide | SER | 0 | ERR751650 | ERR751650 | lineage2.2.1 | th | Thailand | pnca_p.ile5ser | A | E | ILE | IA5 | pnca_complex.pdb |
129 | I5S | L4 | PZA | I | I5 | 5 | S | 1 | MDR | DM | hydrophobic | hydrophilic | non-polar | neutral | non-polar | polar | 11.437 | -0.778 | -3.843 | 5.83176 | -3.518 | -3.58 | 63 | 80 | -0.011 | 5 | 5 | 0 | 0 | strand | 4.26666666666667 | 12.6 | 7.18700589334483e-05 | 9.70142977291842 | 188179.92626441 | Inf | 0.763784339928386 | 30 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -4 | 0 | 0 | 0 | 0 | 0 | 4 | 0 | 2 | 2 | 0 | 0 | 4 | 0 | -0.197061803444782 | -0.993023255813954 | 0.212405393395931 | -0.599829497016198 | -0.93717277486911 | 0.663157894736842 | -0.00906095551894563 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.244 | 0.083 | 6:5 | 146/150 | G:F:I:L:V | 12.1451538387253 | 0.919026337424193 | 119.46804443616 | 0.101660271548307 | 5.0115366606943e-06 | NA | 0.986835744238421 | 0.170978870202674 | 0.767057556984365 | 0.124324963210678 | Inf | 0.382146811758261 | lineage4 | dr_mutations_pyrazinamide | SER | 0 | MDR_18568 | SRR6824524 | lineage4.4 | cn | China: Leiyang City, Hengyang City, Hunan Province | pnca_p.ile5ser | A | E | ILE | IA5 | pnca_complex.pdb |
130 | I5S | L2 | PZA | I | I5 | 5 | S | NA | XDR | DM | hydrophobic | hydrophilic | non-polar | neutral | non-polar | polar | 11.437 | -0.778 | -3.843 | 5.83176 | -3.518 | -3.58 | 63 | 80 | -0.011 | 5 | 5 | 0 | 0 | strand | 4.26666666666667 | 12.6 | 7.18700589334483e-05 | 9.70142977291842 | 188179.92626441 | Inf | 0.763784339928386 | 30 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -4 | 0 | 0 | 0 | 0 | 0 | 4 | 0 | 2 | 2 | 0 | 0 | 4 | 0 | -0.197061803444782 | -0.993023255813954 | 0.212405393395931 | -0.599829497016198 | -0.93717277486911 | 0.663157894736842 | -0.00906095551894563 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.244 | 0.083 | 6:5 | 146/150 | G:F:I:L:V | 12.1451538387253 | 0.919026337424193 | 119.46804443616 | 0.101660271548307 | 5.0115366606943e-06 | NA | 0.986835744238421 | 0.170978870202674 | 0.767057556984365 | 0.124324963210678 | Inf | 0.382146811758261 | lineage2 | dr_mutations_pyrazinamide | SER | 0 | SRR8380939 | SRR8380939 | lineage2.2.1 | in | India | pnca_p.ile5ser | A | E | ILE | IA5 | pnca_complex.pdb |
131 | I5T | L1 | PZA | I | I5 | 5 | T | 1 | MDR | DM | hydrophobic | hydrophobic | non-polar | neutral | non-polar | polar | 11.437 | -0.945 | -3.43 | 3.67776 | -2.709 | -3.3 | 63 | 80 | -0.011 | 5 | 5 | 0 | 0 | strand | 4.26666666666667 | 12.6 | 0.0002874802357337 | 14.5631313131313 | 14.5630810302278 | 14.5631012253236 | 5.81873994206135 | 32 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -4 | 0 | 0 | 0 | 0 | 0 | 4 | 0 | 2 | 2 | 0 | 0 | 4 | 0 | -0.23936170212766 | -0.886304909560723 | 0.133952024708805 | -0.461892583120205 | -0.863874345549738 | 0.663157894736842 | -0.00906095551894563 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.244 | 0.083 | 6:5 | 146/150 | G:F:I:L:V | 2.67848962960141 | 0.0202679102821362 | 1.15384949648317 | 2.3213509541454 | 1.86363317860697 | 294.488177946116 | 1.16325476548539 | 0.0174140488202037 | 1.75910024233227 | 1.16837785201846 | 760.989759542733 | 0.0158563003544608 | lineage1 | dr_mutations_pyrazinamide | THR | 0 | ERR2510512 | ERR2510512 | lineage1.2.2 | pk | Pakistan | pnca_p.ile5thr | A | E | ILE | IA5 | pnca_complex.pdb |
132 | I5T | L4 | PZA | I | I5 | 5 | T | 0 | XDR | DM | hydrophobic | hydrophobic | non-polar | neutral | non-polar | polar | 11.437 | -0.945 | -3.43 | 3.67776 | -2.709 | -3.3 | 63 | 80 | -0.011 | 5 | 5 | 0 | 0 | strand | 4.26666666666667 | 12.6 | 0.0002874802357337 | 14.5631313131313 | 14.5630810302278 | 14.5631012253236 | 5.81873994206135 | 32 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -4 | 0 | 0 | 0 | 0 | 0 | 4 | 0 | 2 | 2 | 0 | 0 | 4 | 0 | -0.23936170212766 | -0.886304909560723 | 0.133952024708805 | -0.461892583120205 | -0.863874345549738 | 0.663157894736842 | -0.00906095551894563 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.244 | 0.083 | 6:5 | 146/150 | G:F:I:L:V | 2.67848962960141 | 0.0202679102821362 | 1.15384949648317 | 2.3213509541454 | 1.86363317860697 | 294.488177946116 | 1.16325476548539 | 0.0174140488202037 | 1.75910024233227 | 1.16837785201846 | 760.989759542733 | 0.0158563003544608 | lineage4 | dr_mutations_pyrazinamide | THR | 0 | ERR2041730 | ERR2041730 | lineage4.8 | rs | Serbia | pnca_p.ile5thr | A | E | ILE | IA5 | pnca_complex.pdb |
133 | I5T | L1 | PZA | I | I5 | 5 | T | NA | MDR | DM | hydrophobic | hydrophobic | non-polar | neutral | non-polar | polar | 11.437 | -0.945 | -3.43 | 3.67776 | -2.709 | -3.3 | 63 | 80 | -0.011 | 5 | 5 | 0 | 0 | strand | 4.26666666666667 | 12.6 | 0.0002874802357337 | 14.5631313131313 | 14.5630810302278 | 14.5631012253236 | 5.81873994206135 | 32 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -4 | 0 | 0 | 0 | 0 | 0 | 4 | 0 | 2 | 2 | 0 | 0 | 4 | 0 | -0.23936170212766 | -0.886304909560723 | 0.133952024708805 | -0.461892583120205 | -0.863874345549738 | 0.663157894736842 | -0.00906095551894563 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.244 | 0.083 | 6:5 | 146/150 | G:F:I:L:V | 2.67848962960141 | 0.0202679102821362 | 1.15384949648317 | 2.3213509541454 | 1.86363317860697 | 294.488177946116 | 1.16325476548539 | 0.0174140488202037 | 1.75910024233227 | 1.16837785201846 | 760.989759542733 | 0.0158563003544608 | lineage1 | dr_mutations_pyrazinamide | THR | 0 | SAMN02599179 | SRR1172873_SRR1172848 | lineage1.1.2 | in | India | pnca_p.ile5thr | A | E | ILE | IA5 | pnca_complex.pdb |
134 | I5T | L2 | PZA | I | I5 | 5 | T | 1 | Pre-XDR | DM | hydrophobic | hydrophobic | non-polar | neutral | non-polar | polar | 11.437 | -0.945 | -3.43 | 3.67776 | -2.709 | -3.3 | 63 | 80 | -0.011 | 5 | 5 | 0 | 0 | strand | 4.26666666666667 | 12.6 | 0.0002874802357337 | 14.5631313131313 | 14.5630810302278 | 14.5631012253236 | 5.81873994206135 | 32 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -4 | 0 | 0 | 0 | 0 | 0 | 4 | 0 | 2 | 2 | 0 | 0 | 4 | 0 | -0.23936170212766 | -0.886304909560723 | 0.133952024708805 | -0.461892583120205 | -0.863874345549738 | 0.663157894736842 | -0.00906095551894563 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.244 | 0.083 | 6:5 | 146/150 | G:F:I:L:V | 2.67848962960141 | 0.0202679102821362 | 1.15384949648317 | 2.3213509541454 | 1.86363317860697 | 294.488177946116 | 1.16325476548539 | 0.0174140488202037 | 1.75910024233227 | 1.16837785201846 | 760.989759542733 | 0.0158563003544608 | lineage2 | dr_mutations_pyrazinamide | THR | 0 | SAMN10961352 | SRR8651582 | lineage2.2.1 | cn | China:Wenzhou | pnca_p.ile5thr | A | E | ILE | IA5 | pnca_complex.pdb |
135 | I5T | L4 | PZA | I | I5 | 5 | T | NA | MDR | DM | hydrophobic | hydrophobic | non-polar | neutral | non-polar | polar | 11.437 | -0.945 | -3.43 | 3.67776 | -2.709 | -3.3 | 63 | 80 | -0.011 | 5 | 5 | 0 | 0 | strand | 4.26666666666667 | 12.6 | 0.0002874802357337 | 14.5631313131313 | 14.5630810302278 | 14.5631012253236 | 5.81873994206135 | 32 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -4 | 0 | 0 | 0 | 0 | 0 | 4 | 0 | 2 | 2 | 0 | 0 | 4 | 0 | -0.23936170212766 | -0.886304909560723 | 0.133952024708805 | -0.461892583120205 | -0.863874345549738 | 0.663157894736842 | -0.00906095551894563 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.244 | 0.083 | 6:5 | 146/150 | G:F:I:L:V | 2.67848962960141 | 0.0202679102821362 | 1.15384949648317 | 2.3213509541454 | 1.86363317860697 | 294.488177946116 | 1.16325476548539 | 0.0174140488202037 | 1.75910024233227 | 1.16837785201846 | 760.989759542733 | 0.0158563003544608 | lineage4 | dr_mutations_pyrazinamide | THR | 0 | ERR779880 | ERR779880 | lineage4.3.4.2 | pe | | pnca_p.ile5thr | A | E | ILE | IA5 | pnca_complex.pdb |
136 | I5T | L4 | PZA | I | I5 | 5 | T | 1 | MDR | DM | hydrophobic | hydrophobic | non-polar | neutral | non-polar | polar | 11.437 | -0.945 | -3.43 | 3.67776 | -2.709 | -3.3 | 63 | 80 | -0.011 | 5 | 5 | 0 | 0 | strand | 4.26666666666667 | 12.6 | 0.0002874802357337 | 14.5631313131313 | 14.5630810302278 | 14.5631012253236 | 5.81873994206135 | 32 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -4 | 0 | 0 | 0 | 0 | 0 | 4 | 0 | 2 | 2 | 0 | 0 | 4 | 0 | -0.23936170212766 | -0.886304909560723 | 0.133952024708805 | -0.461892583120205 | -0.863874345549738 | 0.663157894736842 | -0.00906095551894563 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.244 | 0.083 | 6:5 | 146/150 | G:F:I:L:V | 2.67848962960141 | 0.0202679102821362 | 1.15384949648317 | 2.3213509541454 | 1.86363317860697 | 294.488177946116 | 1.16325476548539 | 0.0174140488202037 | 1.75910024233227 | 1.16837785201846 | 760.989759542733 | 0.0158563003544608 | lineage4 | dr_mutations_pyrazinamide | THR | 0 | ERR551126,ERS457122,4148-04 | ERR551126 | lineage4.1.2.1 | | | pnca_p.ile5thr | A | E | ILE | IA5 | pnca_complex.pdb |
137 | I6L | L2 | PZA | I | I6 | 6 | L | NA | Pre-XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | ERR067611,0341X-sc-2011-09-07T13:19:07Z-1276458 | ERR067611 | lineage2.2.1 | ru | Russia | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
138 | I6L | L2 | PZA | I | I6 | 6 | L | 0 | Pre-XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | ERR133839,0293V-sc-2012-02-09T18:55:51Z-1355172 | ERR133839 | lineage2.2.1 | ru | Russia,Samara | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
139 | I6L | L2 | PZA | I | I6 | 6 | L | 0 | Pre-XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | ERR144633,2073E-sc-2012-02-21T11:38:30Z-1364871 | ERR144633 | lineage2.2.1 | ru | Russia,Samara | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
140 | I6L | L2 | PZA | I | I6 | 6 | L | 0 | Pre-XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | ERR133902,0669D-sc-2012-02-09T18:56:41Z-1355235 | ERR133902 | lineage2.2.1 | ru | Russia,Samara | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
141 | I6L | L2 | PZA | I | I6 | 6 | L | 1 | Pre-XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | 1409H-sc-2012-02-21T11:36:37Z-1364717,ERR137225 | ERR137225 | lineage2.2.1 | ru | Russia,Samara | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
142 | I6L | L2 | PZA | I | I6 | 6 | L | 0 | Pre-XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | ERR067721,0188F-sc-2011-08-25T12:38:23Z-1262320 | ERR067721 | lineage2.2.1 | ru | Russia,Samara | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
143 | I6L | L2 | PZA | I | I6 | 6 | L | NA | Pre-XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | 1239Y-sc-2011-09-07T13:20:01Z-1276545,ERR067698 | ERR067698 | lineage2.2.1 | ru | Russia | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
144 | I6L | L2 | PZA | I | I6 | 6 | L | 1 | Pre-XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | 0696H-sc-2012-02-09T18:56:44Z-1355239,ERR133906 | ERR133906 | lineage2.2.1 | ru | Russia,Samara | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
145 | I6L | L2 | PZA | I | I6 | 6 | L | 0 | XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | ERR234598,0322B-sc-2012-10-11T13:36:31Z-1494084 | ERR234598 | lineage2.2.1 | ru | Russia,Samara | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
146 | I6L | L2 | PZA | I | I6 | 6 | L | 0 | XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | ERR144551,1802K-sc-2012-02-21T11:37:27Z-1364788 | ERR144551 | lineage2.2.1 | ru | Russia,Samara | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
147 | I6L | L2 | PZA | I | I6 | 6 | L | 0 | Pre-XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | 0405R-sc-2012-02-09T18:56:06Z-1355193,ERR133860 | ERR133860 | lineage2.2.1 | ru | Russia,Samara | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
148 | I6L | L2 | PZA | I | I6 | 6 | L | 0 | Pre-XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | 2335P-sc-2012-10-11T13:38:47Z-1494225,ERR228061 | ERR228061 | lineage2.2.1 | ru | Russia,Samara | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
149 | I6L | L2 | PZA | I | I6 | 6 | L | 0 | Pre-XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | 0406S-sc-2011-08-25T12:38:37Z-1262341,ERR067742 | ERR067742 | lineage2.2.1 | ru | Russia,Samara | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
150 | I6L | L2 | PZA | I | I6 | 6 | L | 0 | Pre-XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | ERR133959,0869W-sc-2012-02-09T18:57:22Z-1355292 | ERR133959 | lineage2.2.1 | ru | Russia,Samara | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
151 | I6L | L2;L4 | PZA | I | I6 | 6 | L | 0 | Pre-XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2;lineage4 | other_mutations_pyrazinamide | LEU | 0 | 1815Z-sc-2012-02-21T11:37:31Z-1364793,ERR144556 | ERR144556 | lineage4;lineage2.2.1 | ru | Russia,Samara | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
152 | I6L | L2 | PZA | I | I6 | 6 | L | NA | XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | ERR144591 | ERR144591 | lineage2.2.1 | ru | Russia | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
153 | I6L | L2 | PZA | I | I6 | 6 | L | 0 | Pre-XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | 0367A-sc-2011-09-07T13:19:59Z-1276542,ERR067695 | ERR067695 | lineage2.2.1 | ru | Russia,Samara | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
154 | I6L | L2 | PZA | I | I6 | 6 | L | 0 | Pre-XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | 2140C-sc-2012-04-10T09:16:23Z-1397804,ERR158592 | ERR158592 | lineage2.2.1 | ru | Russia,Samara | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
155 | I6L | L2 | PZA | I | I6 | 6 | L | 0 | Pre-XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | 0458Z-sc-2012-02-09T18:56:10Z-1355199,ERR133866 | ERR133866 | lineage2.2.1 | ru | Russia,Samara | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
156 | I6L | L2 | PZA | I | I6 | 6 | L | 0 | Pre-XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | 2325D-sc-2012-10-11T13:38:01Z-1494177,ERR228013 | ERR228013 | lineage2.2.1 | ru | Russia,Samara | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
157 | I6L | L2 | PZA | I | I6 | 6 | L | NA | Pre-XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | ERR137237,1502J-sc-2012-02-21T11:36:46Z-1364729 | ERR137237 | lineage2.2.1 | ru | Russia | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
158 | I6L | L2 | PZA | I | I6 | 6 | L | 0 | Pre-XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | ERR228029,2327F-sc-2012-10-11T13:38:16Z-1494193 | ERR228029 | lineage2.2.1 | ru | Russia,Samara | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
159 | I6L | L2 | PZA | I | I6 | 6 | L | 0 | Pre-XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | 0664Y-sc-2012-10-11T13:36:35Z-1494088,ERR234602 | ERR234602 | lineage2.2.1 | ru | Russia | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
160 | I6L | L2 | PZA | I | I6 | 6 | L | 0 | Pre-XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | ERR108493,1126A-sc-2011-10-12T14:59:23Z-1289158 | ERR108493 | lineage2.2.1 | ru | Russia,Samara | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
161 | I6L | L2 | PZA | I | I6 | 6 | L | 0 | Pre-XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | 0556F-sc-2012-02-09T18:56:24Z-1355218,ERR133885 | ERR133885 | lineage2.2.1 | ru | Russia,Samara | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
162 | I6L | L2 | PZA | I | I6 | 6 | L | 0 | Pre-XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | ERR144561,1824J-sc-2012-02-21T11:37:34Z-1364798 | ERR144561 | lineage2.2.1 | ru | Russia,Samara | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
163 | I6L | L2 | PZA | I | I6 | 6 | L | 0 | Pre-XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | ERR229966,2393C-sc-2012-10-11T13:39:45Z-1494285 | ERR229966 | lineage2.2.1 | ru | Russia,Samara | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
164 | I6L | L2 | PZA | I | I6 | 6 | L | 0 | Pre-XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | 0915W-sc-2011-09-07T13:19:46Z-1276520,ERR067673 | ERR067673 | lineage2.2.1 | ru | Russia,Samara | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
165 | I6L | L2 | PZA | I | I6 | 6 | L | NA | Pre-XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | ERR230009 | ERR230009 | lineage2.2.1 | ru | Russia | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
166 | I6L | L2 | PZA | I | I6 | 6 | L | NA | Pre-XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | ERR137226 | ERR137226 | lineage2.2.1 | ru | Russia | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
167 | I6L | L2 | PZA | I | I6 | 6 | L | 0 | Pre-XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | ERR067758,0508D-sc-2011-08-25T12:38:45Z-1262357 | ERR067758 | lineage2.2.1 | ru | Russia,Samara | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
168 | I6L | L2 | PZA | I | I6 | 6 | L | NA | Pre-XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | ERR144615,2020X-sc-2012-02-21T11:38:18Z-1364852 | ERR144615 | lineage2.2.1 | ru | Russia | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
169 | I6L | L2 | PZA | I | I6 | 6 | L | 0 | XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | 0389Z-sc-2012-02-09T18:56:02Z-1355187,ERR133854 | ERR133854 | lineage2.2.1 | ru | Russia,Samara | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
170 | I6L | L2 | PZA | I | I6 | 6 | L | 0 | Pre-XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | ERR108473,0967C-sc-2011-10-12T14:59:08Z-1289138 | ERR108473 | lineage2.2.1 | ru | Russia,Samara | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
171 | I6L | L2 | PZA | I | I6 | 6 | L | 0 | Pre-XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | 0761D-sc-2011-10-12T14:59:04Z-1289132,ERR108467 | ERR108467 | lineage2.2.1 | ru | Russia,Samara | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
172 | I6L | L2 | PZA | I | I6 | 6 | L | 0 | XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | ERR234653,2525W-sc-2012-10-11T13:40:29Z-1494331 | ERR234653 | lineage2.2.1 | ru | Russia,Samara | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
173 | I6L | L2 | PZA | I | I6 | 6 | L | 0 | XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | ERR234596,0040V-sc-2012-10-11T13:36:29Z-1494082 | ERR234596 | lineage2.2.1 | ru | Russia,Samara | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
174 | I6L | L2 | PZA | I | I6 | 6 | L | 0 | Pre-XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | 2491J-sc-2012-10-11T13:39:02Z-1494240,ERR229921 | ERR229921 | lineage2.2.1 | ru | Russia,Samara | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
175 | I6L | L2 | PZA | I | I6 | 6 | L | 1 | XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | 0514K-sc-2011-09-07T13:18:57Z-1276439,ERR067592 | ERR067592 | lineage2.2.1 | ru | Russia,Samara | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
176 | I6L | L2 | PZA | I | I6 | 6 | L | 0 | Pre-XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | ERR234595,1355Z-sc-2012-10-11T13:36:28Z-1494081 | ERR234595 | lineage2.2.1 | ru | Russia | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
177 | I6L | L2 | PZA | I | I6 | 6 | L | 0 | Pre-XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | 0622C-sc-2012-10-11T13:36:26Z-1494079,ERR234593 | ERR234593 | lineage2.2.1 | ru | Russia,Samara | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
178 | I6L | L2 | PZA | I | I6 | 6 | L | 0 | Pre-XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | 1723Z-sc-2011-10-12T14:59:54Z-1289202,ERR117468 | ERR117468 | lineage2.2.1 | ru | Russia,Samara | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
179 | I6L | L2 | PZA | I | I6 | 6 | L | 0 | Pre-XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | 2234E-sc-2012-10-11T13:38:05Z-1494181,ERR228017 | ERR228017 | lineage2.2.1 | ru | Russia,Samara | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
180 | I6L | L2 | PZA | I | I6 | 6 | L | NA | XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | ERR133843 | ERR133843 | lineage2.2.1 | ru | Russia | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
181 | I6L | L2 | PZA | I | I6 | 6 | L | 0 | Pre-XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | ERR158611,0031K-sc-2012-04-10T09:16:39Z-1397823 | ERR158611 | lineage2.2.1 | ru | Russia,Samara | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
182 | I6L | L2 | PZA | I | I6 | 6 | L | 1 | Pre-XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | 0175R-sc-2011-09-07T13:18:49Z-1276425,ERR067578 | ERR067578 | lineage2.2.1 | ru | Russia,Samara | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
183 | I6L | L2 | PZA | I | I6 | 6 | L | 0 | Pre-XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | 2385T-sc-2012-10-11T13:38:59Z-1494237,ERR229918 | ERR229918 | lineage2.2.1 | ru | Russia,Samara | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
184 | I6L | L2 | PZA | I | I6 | 6 | L | 0 | Pre-XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | 1782N-sc-2012-02-21T11:37:25Z-1364785,ERR144548 | ERR144548 | lineage2.2.1 | ru | Russia,Samara | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
185 | I6L | L2 | PZA | I | I6 | 6 | L | 0 | Pre-XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | 0076J-sc-2012-10-11T13:35:59Z-1494051,ERR234565 | ERR234565 | lineage2.2.1 | ru | Russia,Samara | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
186 | I6L | L2 | PZA | I | I6 | 6 | L | 0 | Pre-XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | 0773R-sc-2012-02-09T18:57:01Z-1355263,ERR133930 | ERR133930 | lineage2.2.1 | ru | Russia,Samara | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
187 | I6L | L2 | PZA | I | I6 | 6 | L | 0 | Pre-XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | 2338S-sc-2012-10-11T13:39:04Z-1494242,ERR229923 | ERR229923 | lineage2.2.1 | ru | Russia,Samara | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
188 | I6L | L2 | PZA | I | I6 | 6 | L | 1 | Pre-XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | ERR133915,0725P-sc-2012-02-09T18:56:50Z-1355248 | ERR133915 | lineage2.2.1 | ru | Russia,Samara | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
189 | I6L | L2 | PZA | I | I6 | 6 | L | NA | Pre-XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | ERR1023400 | ERR1023400 | lineage2.2.1 | | | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
190 | I6L | L2 | PZA | I | I6 | 6 | L | 0 | Pre-XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | 2089X-sc-2012-04-10T09:16:10Z-1397788,ERR158576 | ERR158576 | lineage2.2.1 | ru | Russia,Samara | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
191 | I6L | L2 | PZA | I | I6 | 6 | L | NA | Pre-XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | ERR067628 | ERR067628 | lineage2.2.1 | ru | Russia | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
192 | I6L | L2 | PZA | I | I6 | 6 | L | 0 | Pre-XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | ERR144590,1892H-sc-2012-02-21T11:38:01Z-1364827 | ERR144590 | lineage2.2.1 | ru | Russia,Samara | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
193 | I6L | L2 | PZA | I | I6 | 6 | L | NA | Pre-XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | ERR067662,0843S-sc-2011-09-07T13:19:38Z-1276509 | ERR067662 | lineage2.2.1 | ru | Russia | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
194 | I6L | L2 | PZA | I | I6 | 6 | L | 0 | Pre-XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | 0571X-sc-2011-08-25T12:38:49Z-1262364,ERR067765 | ERR067765 | lineage2.2.1 | ru | Russia,Samara | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
195 | I6L | L2 | PZA | I | I6 | 6 | L | 1 | XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | ERR137204,1233R-sc-2012-02-21T11:36:23Z-1364696 | ERR137204 | lineage2.2.1 | ru | Russia,Samara | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
196 | I6L | L2 | PZA | I | I6 | 6 | L | 0 | XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | ERR158585,2127N-sc-2012-04-10T09:16:18Z-1397797 | ERR158585 | lineage2.2.1 | ru | Russia,Samara | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
197 | I6L | L2 | PZA | I | I6 | 6 | L | NA | XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | ERR234615,0442G-sc-2012-10-11T13:36:48Z-1494101 | ERR234615 | lineage2.2.1 | ru | Russia | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
198 | I6L | L2 | PZA | I | I6 | 6 | L | 0 | Pre-XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | ERR229946,2508C-sc-2012-10-11T13:39:26Z-1494265 | ERR229946 | lineage2.2.1 | ru | Russia,Samara | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
199 | I6L | L2 | PZA | I | I6 | 6 | L | 0 | XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | 0960V-sc-2011-09-07T13:19:23Z-1276482,ERR067635 | ERR067635 | lineage2.2.1 | ru | Russia,Samara | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
200 | I6L | L2 | PZA | I | I6 | 6 | L | 0 | Pre-XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | ERR234609,0638V-sc-2012-10-11T13:36:42Z-1494095 | ERR234609 | lineage2.2.1 | ru | Russia,Samara | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
201 | I6L | L2 | PZA | I | I6 | 6 | L | 0 | XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | ERR067718,0157X-sc-2011-08-25T12:38:50Z-1262367 | ERR067718 | lineage2.2.1 | ru | Russia,Samara | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
202 | I6L | L4 | PZA | I | I6 | 6 | L | 0 | MDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage4 | other_mutations_pyrazinamide | LEU | 0 | MDR_11168 | SRR6824330 | lineage4.5 | cn | China: Luqiao District, Taizhou City, Zhejiang Province | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
203 | I6L | L2 | PZA | I | I6 | 6 | L | NA | Pre-XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | 1810T-sc-2012-02-21T11:37:28Z-1364790,ERR144553 | ERR144553 | lineage2.2.1 | ru | Russia | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
204 | I6L | L2 | PZA | I | I6 | 6 | L | 1 | MDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | ERR551494 | ERR551494 | lineage2.2.1 | tm | Turkmenistan | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
205 | I6L | L2 | PZA | I | I6 | 6 | L | 0 | Pre-XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | 0609N-sc-2012-02-09T18:56:32Z-1355228,ERR133895 | ERR133895 | lineage2.2.1 | ru | Russia,Samara | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
206 | I6L | L2 | PZA | I | I6 | 6 | L | 0 | Pre-XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | 0818Q-sc-2011-09-07T13:19:32Z-1276498,ERR067651 | ERR067651 | lineage2.2.1 | ru | Russia,Samara | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
207 | I6L | L2 | PZA | I | I6 | 6 | L | NA | XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | SRR7517822 | SRR7517822 | lineage2.2.1 | ch | Switzerland | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
208 | I6L | L2 | PZA | I | I6 | 6 | L | 0 | Pre-XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | ERR158613,0145J-sc-2012-04-10T09:16:40Z-1397825 | ERR158613 | lineage2.2.1 | ru | Russia,Samara | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
209 | I6L | L2 | PZA | I | I6 | 6 | L | 0 | Pre-XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | 2516L-sc-2012-10-11T13:40:12Z-1494313,ERR229994 | ERR229994 | lineage2.2.1 | ru | Russia,Samara | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
210 | I6L | L2 | PZA | I | I6 | 6 | L | 0 | XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | ERR234560,0469L-sc-2012-10-11T13:35:54Z-1494046 | ERR234560 | lineage2.2.1 | ru | Russia,Samara | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
211 | I6L | L2 | PZA | I | I6 | 6 | L | 1 | Pre-XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | 0259H-sc-2012-02-09T18:55:43Z-1355160,ERR133827 | ERR133827 | lineage2.2.1 | ru | Russia,Samara | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
212 | I6L | L2 | PZA | I | I6 | 6 | L | 0 | Pre-XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | 1797E-sc-2012-02-21T11:37:25Z-1364786,ERR144549 | ERR144549 | lineage2.2.1 | ru | Russia,Samara | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
213 | I6L | L2 | PZA | I | I6 | 6 | L | 0 | Pre-XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | 1825K-sc-2012-02-21T11:37:36Z-1364799,ERR144562 | ERR144562 | lineage2.2.1 | ru | Russia,Samara | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
214 | I6L | L2 | PZA | I | I6 | 6 | L | NA | Pre-XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | 1736N-sc-2012-02-21T11:37:09Z-1364764,ERR137272 | ERR137272 | lineage2.2.1 | ru | Russia | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
215 | I6L | L2 | PZA | I | I6 | 6 | L | 0 | Pre-XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | ERR067587,0345B-sc-2011-09-07T13:18:54Z-1276434 | ERR067587 | lineage2.2.1 | ru | Russia,Samara | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
216 | I6L | L2 | PZA | I | I6 | 6 | L | 0 | XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | ERR234576,0495P-sc-2012-10-11T13:36:09Z-1494062 | ERR234576 | lineage2.2.1 | ru | Russia,Samara | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
217 | I6L | L2 | PZA | I | I6 | 6 | L | 0 | Pre-XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | 0816N-sc-2011-09-07T13:19:31Z-1276496,ERR067649 | ERR067649 | lineage2.2.1 | ru | Russia,Samara | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
218 | I6L | L2 | PZA | I | I6 | 6 | L | 0 | Pre-XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | ERR234623,0462D-sc-2012-10-11T13:36:55Z-1494109 | ERR234623 | lineage2.2.1 | ru | Russia,Samara | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
219 | I6L | L2 | PZA | I | I6 | 6 | L | 0 | Pre-XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | 0475S-sc-2011-08-25T12:38:43Z-1262353,ERR067754 | ERR067754 | lineage2.2.1 | ru | Russia,Samara | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
220 | I6L | L2 | PZA | I | I6 | 6 | L | 0 | Pre-XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | 0570W-sc-2012-02-09T18:56:25Z-1355219,ERR133886 | ERR133886 | lineage2.2.1 | ru | Russia,Samara | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
221 | I6L | L2 | PZA | I | I6 | 6 | L | NA | XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | 0391B-sc-2011-09-07T13:19:16Z-1276470,ERR067623 | ERR067623 | lineage2.2.1 | ru | Russia | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
222 | I6L | L2 | PZA | I | I6 | 6 | L | 0 | Pre-XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | ERR117470,1346P-sc-2011-10-12T14:59:56Z-1289204 | ERR117470 | lineage2.2.1 | ru | Russia,Samara | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
223 | I6L | L2 | PZA | I | I6 | 6 | L | NA | XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | ERR133848,0330K-sc-2012-02-09T18:55:57Z-1355181 | ERR133848 | lineage2.2.1 | ru | Russia | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
224 | I6L | L2 | PZA | I | I6 | 6 | L | NA | Pre-XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | 0383S-sc-2011-08-25T12:38:35Z-1262338,ERR067739 | ERR067739 | lineage2.2.1 | ru | Russia | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
225 | I6L | L2 | PZA | I | I6 | 6 | L | 0 | Pre-XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | 2639V-sc-2012-10-11T13:41:12Z-1494376,ERR234698 | ERR234698 | lineage2.2.1 | ru | Russia,Samara | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
226 | I6L | L2 | PZA | I | I6 | 6 | L | NA | Pre-XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | ERR108491,1040G-sc-2011-10-12T14:59:22Z-1289156 | ERR108491 | lineage2.2.1 | ru | Russia | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
227 | I6L | L2;L4 | PZA | I | I6 | 6 | L | 0 | Pre-XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2;lineage4 | other_mutations_pyrazinamide | LEU | 0 | 2549X-sc-2012-10-11T13:40:42Z-1494344,ERR234666 | ERR234666 | lineage4;lineage2.2.1 | ru | Russia,Samara | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
228 | I6L | L2 | PZA | I | I6 | 6 | L | 0 | Pre-XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | ERR228020,2311N-sc-2012-10-11T13:38:07Z-1494184 | ERR228020 | lineage2.2.1 | ru | Russia,Samara | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
229 | I6L | L2 | PZA | I | I6 | 6 | L | NA | Pre-XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | ERR108454 | ERR108454 | lineage2.2.1 | ru | Russia | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
230 | I6L | L2 | PZA | I | I6 | 6 | L | 0 | Pre-XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | ERR027455 | ERR027455 | lineage2.2.1 | ru | Russia | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
231 | I6L | L2 | PZA | I | I6 | 6 | L | 0 | Pre-XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | ERR108489,1030W-sc-2011-10-12T14:59:20Z-1289154 | ERR108489 | lineage2.2.1 | ru | Russia,Samara | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
232 | I6L | L2 | PZA | I | I6 | 6 | L | 0 | Pre-XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | ERR228064,2215J-sc-2012-10-11T13:38:50Z-1494228 | ERR228064 | lineage2.2.1 | ru | Russia,Samara | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
233 | I6L | L2 | PZA | I | I6 | 6 | L | 0 | Pre-XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | 2135X-sc-2012-04-10T09:16:22Z-1397802,ERR158590 | ERR158590 | lineage2.2.1 | ru | Russia,Samara | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
234 | I6L | L2 | PZA | I | I6 | 6 | L | 0 | Pre-XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | ERR229924,2352H-sc-2012-10-11T13:39:05Z-1494243 | ERR229924 | lineage2.2.1 | ru | Russia,Samara | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
235 | I6L | L2 | PZA | I | I6 | 6 | L | NA | XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | 0481Z-sc-2012-10-11T13:36:01Z-1494054,ERR234568 | ERR234568 | lineage2.2.1 | ru | Russia | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
236 | I6L | L2 | PZA | I | I6 | 6 | L | 0 | Pre-XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | ERR144597,1917K-sc-2012-02-21T11:38:05Z-1364834 | ERR144597 | lineage2.2.1 | ru | Russia,Samara | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
237 | I6L | L2 | PZA | I | I6 | 6 | L | NA | Pre-XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | 0833G-sc-2011-09-07T13:19:34Z-1276501,ERR067654 | ERR067654 | lineage2.2.1 | ru | Russia,Samara | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
238 | I6L | L2;L4 | PZA | I | I6 | 6 | L | 0 | Pre-XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2;lineage4 | other_mutations_pyrazinamide | LEU | 0 | ERR234570,0658R-sc-2012-10-11T13:36:03Z-1494056 | ERR234570 | lineage4;lineage2.2.1 | ru | Russia,Samara | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
239 | I6L | L2 | PZA | I | I6 | 6 | L | 0 | Pre-XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | 0666A-sc-2012-10-11T13:36:50Z-1494104,ERR234618 | ERR234618 | lineage2.2.1 | ru | Russia,Samara | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
240 | I6L | L2 | PZA | I | I6 | 6 | L | 0 | XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | 1921P-sc-2012-02-21T11:38:08Z-1364837,ERR144600 | ERR144600 | lineage2.2.1 | ru | Russia,Samara | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
241 | I6L | L2 | PZA | I | I6 | 6 | L | 0 | Pre-XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | 2072D-sc-2012-02-21T11:38:30Z-1364870,ERR144632 | ERR144632 | lineage2.2.1 | ru | Russia,Samara | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
242 | I6L | L2 | PZA | I | I6 | 6 | L | 0 | Pre-XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | ERR067663,0844T-sc-2011-09-07T13:19:39Z-1276510 | ERR067663 | lineage2.2.1 | ru | Russia,Samara | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
243 | I6L | L2 | PZA | I | I6 | 6 | L | 0 | Pre-XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | 1366L-sc-2012-02-21T11:36:34Z-1364712,ERR137220 | ERR137220 | lineage2.2.1 | ru | Russia,Samara | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
244 | I6L | L2 | PZA | I | I6 | 6 | L | 0 | Pre-XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | ERR228019,2287M-sc-2012-10-11T13:38:07Z-1494183 | ERR228019 | lineage2.2.1 | ru | Russia,Samara | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
245 | I6L | L2 | PZA | I | I6 | 6 | L | NA | Pre-XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | 2369B-sc-2012-10-11T13:39:13Z-1494252,ERR229933 | ERR229933 | lineage2.2.1 | ru | Russia | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
246 | I6L | L2 | PZA | I | I6 | 6 | L | NA | Pre-XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | 2249W-sc-2012-10-11T13:37:27Z-1494142,ERR227978 | ERR227978 | lineage2.2.1 | ru | Russia | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
247 | I6L | L2 | PZA | I | I6 | 6 | L | 0 | Pre-XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | ERR133953,0826Z-sc-2012-02-09T18:57:18Z-1355286 | ERR133953 | lineage2.2.1 | ru | Russia,Samara | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
248 | I6L | L2 | PZA | I | I6 | 6 | L | NA | Pre-XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | ERR158597,2152Q-sc-2012-04-10T09:16:26Z-1397809 | ERR158597 | lineage2.2.1 | ru | Russia | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
249 | I6L | L2 | PZA | I | I6 | 6 | L | NA | Pre-XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | ETB0088 | SRR6257030 | lineage2.2.1 | ru | Russia:Samara | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
250 | I6L | L2 | PZA | I | I6 | 6 | L | 0 | Pre-XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | 1705E-sc-2012-02-21T11:37:02Z-1364754,ERR137262 | ERR137262 | lineage2.2.1 | ru | Russia,Samara | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
251 | I6L | L2 | PZA | I | I6 | 6 | L | 0 | XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | ERR067704,1467W-sc-2011-09-07T13:20:04Z-1276551 | ERR067704 | lineage2.2.1 | ru | Russia,Samara | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
252 | I6L | L2 | PZA | I | I6 | 6 | L | 0 | XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | ERR144611,2011M-sc-2012-02-21T11:38:15Z-1364848 | ERR144611 | lineage2.2.1 | ru | Russia,Samara | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
253 | I6L | L2 | PZA | I | I6 | 6 | L | NA | Pre-XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | ERR228054 | ERR228054 | lineage2.2.1 | ru | Russia | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
254 | I6L | L2 | PZA | I | I6 | 6 | L | NA | Pre-XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | SAMN02414916 | SRR1146417_SRR1162881_SRR1163087_SRR1144810 | lineage2.2.1 | se | Sweden | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
255 | I6L | L2 | PZA | I | I6 | 6 | L | 0 | Pre-XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | 1596L-sc-2011-10-12T14:58:40Z-1289101,ERR108436 | ERR108436 | lineage2.2.1 | ru | Russia,Samara | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
256 | I6L | L2 | PZA | I | I6 | 6 | L | NA | XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | 0187E-sc-2011-08-25T12:38:22Z-1262319,ERR067720 | ERR067720 | lineage2.2.1 | ru | Russia | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
257 | I6L | L2 | PZA | I | I6 | 6 | L | NA | Pre-XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | ERR027458 | ERR027458 | lineage2.2.1 | ru | Russia | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
258 | I6L | L2 | PZA | I | I6 | 6 | L | 0 | XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | ERR229960,2484B-sc-2012-10-11T13:39:39Z-1494279 | ERR229960 | lineage2.2.1 | ru | Russia,Samara | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
259 | I6L | L2 | PZA | I | I6 | 6 | L | 0 | XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | ERR227996,2308K-sc-2012-10-11T13:37:45Z-1494160 | ERR227996 | lineage2.2.1 | ru | Russia,Samara | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
260 | I6L | L2 | PZA | I | I6 | 6 | L | 0 | Pre-XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | ERR133806,0126N-sc-2012-02-09T18:55:27Z-1355139 | ERR133806 | lineage2.2.1 | ru | Russia,Samara | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
261 | I6L | L4 | PZA | I | I6 | 6 | L | NA | MDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage4 | other_mutations_pyrazinamide | LEU | 0 | ERR2179654 | ERR2179654 | lineage4.5 | cn | China | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
262 | I6L | L2 | PZA | I | I6 | 6 | L | NA | Pre-XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | ERR108484,1002Q-sc-2011-10-12T14:59:16Z-1289149 | ERR108484 | lineage2.2.1 | ru | Russia | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
263 | I6L | L2 | PZA | I | I6 | 6 | L | NA | Pre-XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | ERR229980,2362T-sc-2012-10-11T13:39:58Z-1494299 | ERR229980 | lineage2.2.1 | ru | Russia | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
264 | I6L | L2 | PZA | I | I6 | 6 | L | 0 | Pre-XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | 0928K-sc-2011-10-12T14:59:49Z-1289194,ERR117460 | ERR117460 | lineage2.2.1 | ru | Russia,Samara | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
265 | I6L | L2 | PZA | I | I6 | 6 | L | 0 | Pre-XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | ERR137281,1755J-sc-2012-02-21T11:37:17Z-1364773 | ERR137281 | lineage2.2.1 | ru | Russia,Samara | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
266 | I6L | L2 | PZA | I | I6 | 6 | L | 0 | Pre-XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | ERR158586,2128P-sc-2012-04-10T09:16:18Z-1397798 | ERR158586 | lineage2.2.1 | ru | Russia,Samara | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
267 | I6L | L2 | PZA | I | I6 | 6 | L | NA | Pre-XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | ERR067741,0386W-sc-2011-08-25T12:38:36Z-1262340 | ERR067741 | lineage2.2.1 | ru | Russia | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
268 | I6L | L2 | PZA | I | I6 | 6 | L | 0 | Pre-XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | ERR067762,0512H-sc-2011-08-25T12:38:47Z-1262361 | ERR067762 | lineage2.2.1 | ru | Russia,Samara | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
269 | I6L | L2 | PZA | I | I6 | 6 | L | 0 | Pre-XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | ERR133826,0255D-sc-2012-02-09T18:55:42Z-1355159 | ERR133826 | lineage2.2.1 | ru | Russia,Samara | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
270 | I6L | L2 | PZA | I | I6 | 6 | L | 0 | Pre-XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | 1559W-sc-2011-09-07T13:20:10Z-1276562,ERR067715 | ERR067715 | lineage2.2.1 | ru | Russia,Samara | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
271 | I6L | L4 | PZA | I | I6 | 6 | L | NA | MDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage4 | other_mutations_pyrazinamide | LEU | 0 | SRS797396 | SRR1723935 | lineage4.5 | cn | China:Zhejiang | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
272 | I6L | L2 | PZA | I | I6 | 6 | L | 0 | XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | ERR234633,0647E-sc-2012-10-11T13:37:05Z-1494119 | ERR234633 | lineage2.2.1 | ru | Russia,Samara | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
273 | I6L | L2 | PZA | I | I6 | 6 | L | 1 | Pre-XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | 0338T-sc-2012-10-11T13:36:54Z-1494108,ERR234622 | ERR234622 | lineage2.2.1 | ru | Russia,Samara | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
274 | I6L | L2 | PZA | I | I6 | 6 | L | 0 | Pre-XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | ERR133889,0590S-sc-2012-02-09T18:56:26Z-1355222 | ERR133889 | lineage2.2.1 | ru | Russia,Samara | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
275 | I6L | L2 | PZA | I | I6 | 6 | L | 0 | Pre-XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | ERR067583,0217M-sc-2011-09-07T13:18:51Z-1276430 | ERR067583 | lineage2.2.1 | ru | Russia,Samara | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
276 | I6L | L2 | PZA | I | I6 | 6 | L | 0 | Pre-XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | 0897B-sc-2011-10-12T14:58:57Z-1289123,ERR108458 | ERR108458 | lineage2.2.1 | ru | Russia,Samara | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
277 | I6L | L2 | PZA | I | I6 | 6 | L | 0 | Pre-XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | 1271H-sc-2012-02-21T11:36:28Z-1364702,ERR137210 | ERR137210 | lineage2.2.1 | ru | Russia,Samara | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
278 | I6L | L2 | PZA | I | I6 | 6 | L | 0 | XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | ERR234641,0649G-sc-2012-10-11T13:37:13Z-1494127 | ERR234641 | lineage2.2.1 | ru | Russia,Samara | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
279 | I6L | L2 | PZA | I | I6 | 6 | L | NA | Pre-XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | 1474D-sc-2011-09-07T13:20:08Z-1276557,ERR067710 | ERR067710 | lineage2.2.1 | ru | Russia | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
280 | I6L | L2 | PZA | I | I6 | 6 | L | 0 | Pre-XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | 1860Y-sc-2012-02-21T11:37:46Z-1364812,ERR144575 | ERR144575 | lineage2.2.1 | ru | Russia,Samara | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
281 | I6L | L2 | PZA | I | I6 | 6 | L | 0 | Pre-XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | ERR067656,0835J-sc-2011-09-07T13:19:35Z-1276503 | ERR067656 | lineage2.2.1 | ru | Russia,Samara | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
282 | I6L | L2 | PZA | I | I6 | 6 | L | 1 | Pre-XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | ETB0040 | SRR6257082 | lineage2.2.1 | ru | Russia:Samara | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
283 | I6L | L2 | PZA | I | I6 | 6 | L | 0 | Pre-XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | ERR019564 | ERR019564 | lineage2.2.1 | ru | Russia | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
284 | I6L | L2 | PZA | I | I6 | 6 | L | NA | XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | 0312Q-sc-2012-02-09T18:55:55Z-1355178,ERR133845 | ERR133845 | lineage2.2.1 | ru | Russia | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
285 | I6L | L2 | PZA | I | I6 | 6 | L | 0 | XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | ERR144593,1901S-sc-2012-02-21T11:38:03Z-1364830 | ERR144593 | lineage2.2.1 | ru | Russia,Samara | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
286 | I6L | L2 | PZA | I | I6 | 6 | L | 0 | Pre-XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | 0273Y-sc-2012-02-09T18:55:45Z-1355164,ERR133831 | ERR133831 | lineage2.2.1 | ru | Russia,Samara | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
287 | I6L | L2 | PZA | I | I6 | 6 | L | 0 | XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | ERR144543,1770A-sc-2012-02-21T11:37:22Z-1364780 | ERR144543 | lineage2.2.1 | ru | Russia,Samara | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
288 | I6L | L2 | PZA | I | I6 | 6 | L | 0 | Pre-XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | ERR137283,1765V-sc-2012-02-21T11:37:18Z-1364775 | ERR137283 | lineage2.2.1 | ru | Russia,Samara | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
289 | I6L | L2 | PZA | I | I6 | 6 | L | 0 | Pre-XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | ERR019559 | ERR019559 | lineage2.2.1 | ru | Russia | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
290 | I6L | L2 | PZA | I | I6 | 6 | L | 0 | Pre-XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | 0163D-sc-2011-09-07T13:18:46Z-1276423,ERR067576 | ERR067576 | lineage2.2.1 | ru | Russia,Samara | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
291 | I6L | L2 | PZA | I | I6 | 6 | L | 0 | Pre-XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | ERR067620,0053J-sc-2011-09-07T13:19:14Z-1276467 | ERR067620 | lineage2.2.1 | ru | Russia,Samara | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
292 | I6L | L2 | PZA | I | I6 | 6 | L | 0 | XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | ERR229962,2512G-sc-2012-10-11T13:39:41Z-1494281 | ERR229962 | lineage2.2.1 | ru | Russia,Samara | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
293 | I6L | L2 | PZA | I | I6 | 6 | L | 0 | Pre-XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | 0817P-sc-2011-09-07T13:19:31Z-1276497,ERR067650 | ERR067650 | lineage2.2.1 | ru | Russia,Samara | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
294 | I6L | L2 | PZA | I | I6 | 6 | L | 0 | Pre-XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | ERR234574,0283J-sc-2012-10-11T13:36:07Z-1494060 | ERR234574 | lineage2.2.1 | ru | Russia,Samara | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
295 | I6L | L2 | PZA | I | I6 | 6 | L | 0 | XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | ERR234590,0292T-sc-2012-10-11T13:36:23Z-1494076 | ERR234590 | lineage2.2.1 | ru | Russia,Samara | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
296 | I6L | L2 | PZA | I | I6 | 6 | L | 0 | Pre-XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | ERR067613,0628J-sc-2011-09-07T13:19:09Z-1276460 | ERR067613 | lineage2.2.1 | ru | Russia,Samara | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
297 | I6L | L2 | PZA | I | I6 | 6 | L | NA | Pre-XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | ERR133853,0388Y-sc-2012-02-09T18:56:01Z-1355186 | ERR133853 | lineage2.2.1 | ru | Russia | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
298 | I6L | L2 | PZA | I | I6 | 6 | L | 0 | Pre-XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | 1475E-sc-2011-09-07T13:20:08Z-1276558,ERR067711 | ERR067711 | lineage2.2.1 | ru | Russia,Samara | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
299 | I6L | L2 | PZA | I | I6 | 6 | L | NA | Pre-XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | ERR067652,0828B-sc-2011-09-07T13:19:33Z-1276499 | ERR067652 | lineage2.2.1 | ru | Russia | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
300 | I6L | L2 | PZA | I | I6 | 6 | L | 0 | Pre-XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | ERR234660,2535G-sc-2012-10-11T13:40:36Z-1494338 | ERR234660 | lineage2.2.1 | ru | Russia,Samara | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
301 | I6L | L2 | PZA | I | I6 | 6 | L | 0 | Pre-XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | 1432H-sc-2012-02-21T11:36:41Z-1364722,ERR137230 | ERR137230 | lineage2.2.1 | ru | Russia,Samara | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
302 | I6L | L2 | PZA | I | I6 | 6 | L | 0 | Pre-XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | 0071D-sc-2011-10-12T14:59:29Z-1289167,ERR108502 | ERR108502 | lineage2.2.1 | ru | Russia,Samara | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
303 | I6L | L2 | PZA | I | I6 | 6 | L | NA | Pre-XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | 2281F-sc-2012-10-11T13:37:44Z-1494159,ERR227995 | ERR227995 | lineage2.2.1 | ru | Russia | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
304 | I6L | L2 | PZA | I | I6 | 6 | L | NA | XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | ERR229916,2351G-sc-2012-10-11T13:38:57Z-1494235 | ERR229916 | lineage2.2.1 | ru | Russia | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
305 | I6L | L2 | PZA | I | I6 | 6 | L | 0 | Pre-XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | 2052G-sc-2012-02-21T11:38:26Z-1364865,ERR144628 | ERR144628 | lineage2.2.1 | ru | Russia,Samara | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
306 | I6L | L2 | PZA | I | I6 | 6 | L | NA | Pre-XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | 0052H-sc-2012-10-11T13:37:00Z-1494114,ERR234628 | ERR234628 | lineage2.2.1 | ru | Russia | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
307 | I6L | L2 | PZA | I | I6 | 6 | L | 0 | Pre-XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | ERR133944,0799V-sc-2012-02-09T18:57:11Z-1355277 | ERR133944 | lineage2.2.1 | ru | Russia,Samara | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
308 | I6L | L2 | PZA | I | I6 | 6 | L | NA | Pre-XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | ERR137211,1284X-sc-2012-02-21T11:36:28Z-1364703 | ERR137211 | lineage2.2.1 | ru | Russia | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
309 | I6L | L2 | PZA | I | I6 | 6 | L | 0 | Pre-XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | ERR137222,1391N-sc-2012-02-21T11:36:35Z-1364714 | ERR137222 | lineage2.2.1 | ru | Russia,Samara | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
310 | I6L | L2 | PZA | I | I6 | 6 | L | 0 | Pre-XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | ERR137269,1731H-sc-2012-02-21T11:37:07Z-1364761 | ERR137269 | lineage2.2.1 | ru | Russia,Samara | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
311 | I6L | L2 | PZA | I | I6 | 6 | L | 0 | Pre-XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | ERR133868,0484C-sc-2012-02-09T18:56:12Z-1355201 | ERR133868 | lineage2.2.1 | ru | Russia,Samara | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
312 | I6L | L2 | PZA | I | I6 | 6 | L | 0 | Pre-XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | 1741T-sc-2012-02-21T11:37:13Z-1364769,ERR137277 | ERR137277 | lineage2.2.1 | ru | Russia,Samara | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
313 | I6L | L2 | PZA | I | I6 | 6 | L | 0 | Pre-XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | 2053H-sc-2012-10-11T13:38:32Z-1494210,ERR228046 | ERR228046 | lineage2.2.1 | ru | Russia,Samara | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
314 | I6L | L2 | PZA | I | I6 | 6 | L | 0 | Pre-XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | 0978P-sc-2011-10-12T14:59:09Z-1289140,ERR108475 | ERR108475 | lineage2.2.1 | ru | Russia,Samara | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
315 | I6L | L2 | PZA | I | I6 | 6 | L | NA | Pre-XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.018 | -0.548 | 0.267883 | -1.616 | -0.58 | 5 | 53 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0097024579560155 | 0.385310257492613 | 0.385311080310026 | 0.385326683377145 | 8.35414540919546 | -6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -7 | 0 | -2 | -5 | 2 | 0 | -2 | -2 | -0.764437689969605 | -0.141602067183462 | 0.00975688197029407 | -0.275532821824382 | -0.151832460732984 | 0.0526315789473684 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -0.953704270146009 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | -0.414189429312607 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 0.0038480840706912 | lineage2 | other_mutations_pyrazinamide | LEU | 0 | ERR019575 | ERR019575 | lineage2.2.1 | ru | Russia | pnca_p.ile6leu | A | E | ILE | IA6 | pnca_complex.pdb |
316 | I6M | L4 | PZA | I | I6 | 6 | M | NA | MDR | DM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -3.085 | -1.021 | 0.24349 | -2.364 | 0.14 | 10 | 59 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | NA | NA | NA | NA | NA | -32 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -3 | 0 | 0 | -3 | -2 | 0 | -4 | -2 | -0.781408308004053 | -0.263824289405685 | 0.00886843581319794 | -0.40306905370844 | 0.0786516853932584 | 0.105263157894737 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Stabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | lineage4 | dr_mutations_pyrazinamide | MET | 0 | ERR1555057 | ERR1555057 | lineage4.3.3 | | | pnca_p.ile6met | A | E | ILE | IA6 | pnca_complex.pdb |
317 | I6S | L2 | PZA | I | I6 | 6 | S | 1 | Pre-XDR | DM | hydrophobic | hydrophilic | non-polar | neutral | non-polar | polar | 9.258 | -1.047 | -3.585 | 6.01751 | -4.149 | -3.42 | 64 | 80 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0001437401178668 | 19.411022297013 | 511754.463552573 | Inf | 4.73122070382274 | 24 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 0 | -1 | 0 | -1 | 0 | 2 | 0 | 4 | 0 | -0.265197568389058 | -0.926356589147287 | 0.219170812724452 | -0.707416879795396 | -0.895287958115183 | 0.673684210526316 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | 13.1456002256205 | 0.924803768446996 | 139.277183326562 | 0.094384449136928 | 0.0001628371344453 | NA | 1.28804840845689 | 0.0292235860951597 | 1.53426649183163 | 0.91081598550184 | Inf | 0.0296198560706035 | lineage2 | dr_mutations_pyrazinamide | SER | 0 | ERR2516977 | ERR2516977 | lineage2.2.1 | gb | UK | pnca_p.ile6ser | A | E | ILE | IA6 | pnca_complex.pdb |
318 | I6S | L2 | PZA | I | I6 | 6 | S | 1 | Pre-XDR | DM | hydrophobic | hydrophilic | non-polar | neutral | non-polar | polar | 9.258 | -1.047 | -3.585 | 6.01751 | -4.149 | -3.42 | 64 | 80 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.0001437401178668 | 19.411022297013 | 511754.463552573 | Inf | 4.73122070382274 | 24 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 0 | -1 | 0 | -1 | 0 | 2 | 0 | 4 | 0 | -0.265197568389058 | -0.926356589147287 | 0.219170812724452 | -0.707416879795396 | -0.895287958115183 | 0.673684210526316 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | 13.1456002256205 | 0.924803768446996 | 139.277183326562 | 0.094384449136928 | 0.0001628371344453 | NA | 1.28804840845689 | 0.0292235860951597 | 1.53426649183163 | 0.91081598550184 | Inf | 0.0296198560706035 | lineage2 | dr_mutations_pyrazinamide | SER | 0 | ERR2516895 | ERR2516895 | lineage2.2.1 | gb | UK | pnca_p.ile6ser | A | E | ILE | IA6 | pnca_complex.pdb |
319 | I6T | L2 | PZA | I | I6 | 6 | T | 1 | XDR | DM | hydrophobic | hydrophobic | non-polar | neutral | non-polar | polar | 9.258 | -1.244 | -3.089 | 3.71452 | -3.589 | -3.14 | 62 | 80 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.000646830530401 | 87.6075949367089 | 1395214.80217275 | Inf | 38.0099632572142 | 24 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 0 | -1 | 0 | -1 | 0 | 2 | 0 | 0 | 0 | -0.315096251266464 | -0.798191214470284 | 0.135290903925582 | -0.611935208866155 | -0.821989528795812 | 0.652631578947368 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | 14.148558941436 | 0.896008552350165 | 108.247901039825 | 0.130705157379733 | 226.474535586036 | NA | 1.94254175795031 | 1.23317897951184e-07 | 6.90897388676731 | 9.59561062779463 | Inf | 7.038428913028e-10 | lineage2 | dr_mutations_pyrazinamide | THR | 0 | ERR2510686 | ERR2510686 | lineage2.2.1 | it | Italy | pnca_p.ile6thr | A | E | ILE | IA6 | pnca_complex.pdb |
320 | I6T | L1 | PZA | I | I6 | 6 | T | NA | MDR | DM | hydrophobic | hydrophobic | non-polar | neutral | non-polar | polar | 9.258 | -1.244 | -3.089 | 3.71452 | -3.589 | -3.14 | 62 | 80 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.000646830530401 | 87.6075949367089 | 1395214.80217275 | Inf | 38.0099632572142 | 24 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 0 | -1 | 0 | -1 | 0 | 2 | 0 | 0 | 0 | -0.315096251266464 | -0.798191214470284 | 0.135290903925582 | -0.611935208866155 | -0.821989528795812 | 0.652631578947368 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | 14.148558941436 | 0.896008552350165 | 108.247901039825 | 0.130705157379733 | 226.474535586036 | NA | 1.94254175795031 | 1.23317897951184e-07 | 6.90897388676731 | 9.59561062779463 | Inf | 7.038428913028e-10 | lineage1 | dr_mutations_pyrazinamide | THR | 0 | SAMN02414908 | SRR1163076_SRR1144791_SRR1163465_SRR1146277 | lineage1.1.2 | se | Sweden | pnca_p.ile6thr | A | E | ILE | IA6 | pnca_complex.pdb |
321 | I6T | L4 | PZA | I | I6 | 6 | T | 1 | Pre-XDR | DM | hydrophobic | hydrophobic | non-polar | neutral | non-polar | polar | 9.258 | -1.244 | -3.089 | 3.71452 | -3.589 | -3.14 | 62 | 80 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.000646830530401 | 87.6075949367089 | 1395214.80217275 | Inf | 38.0099632572142 | 24 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 0 | -1 | 0 | -1 | 0 | 2 | 0 | 0 | 0 | -0.315096251266464 | -0.798191214470284 | 0.135290903925582 | -0.611935208866155 | -0.821989528795812 | 0.652631578947368 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | 14.148558941436 | 0.896008552350165 | 108.247901039825 | 0.130705157379733 | 226.474535586036 | NA | 1.94254175795031 | 1.23317897951184e-07 | 6.90897388676731 | 9.59561062779463 | Inf | 7.038428913028e-10 | lineage4 | dr_mutations_pyrazinamide | THR | 0 | ERR2510434 | ERR2510434 | lineage4.9 | pk | Pakistan | pnca_p.ile6thr | A | E | ILE | IA6 | pnca_complex.pdb |
322 | I6T | L2 | PZA | I | I6 | 6 | T | 1 | XDR | DM | hydrophobic | hydrophobic | non-polar | neutral | non-polar | polar | 9.258 | -1.244 | -3.089 | 3.71452 | -3.589 | -3.14 | 62 | 80 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.000646830530401 | 87.6075949367089 | 1395214.80217275 | Inf | 38.0099632572142 | 24 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 0 | -1 | 0 | -1 | 0 | 2 | 0 | 0 | 0 | -0.315096251266464 | -0.798191214470284 | 0.135290903925582 | -0.611935208866155 | -0.821989528795812 | 0.652631578947368 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | 14.148558941436 | 0.896008552350165 | 108.247901039825 | 0.130705157379733 | 226.474535586036 | NA | 1.94254175795031 | 1.23317897951184e-07 | 6.90897388676731 | 9.59561062779463 | Inf | 7.038428913028e-10 | lineage2 | dr_mutations_pyrazinamide | THR | 0 | ERR2510710 | ERR2510710 | lineage2.2.1 | it | Italy | pnca_p.ile6thr | A | E | ILE | IA6 | pnca_complex.pdb |
323 | I6T | L2 | PZA | I | I6 | 6 | T | 1 | XDR | DM | hydrophobic | hydrophobic | non-polar | neutral | non-polar | polar | 9.258 | -1.244 | -3.089 | 3.71452 | -3.589 | -3.14 | 62 | 80 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.000646830530401 | 87.6075949367089 | 1395214.80217275 | Inf | 38.0099632572142 | 24 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 0 | -1 | 0 | -1 | 0 | 2 | 0 | 0 | 0 | -0.315096251266464 | -0.798191214470284 | 0.135290903925582 | -0.611935208866155 | -0.821989528795812 | 0.652631578947368 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | 14.148558941436 | 0.896008552350165 | 108.247901039825 | 0.130705157379733 | 226.474535586036 | NA | 1.94254175795031 | 1.23317897951184e-07 | 6.90897388676731 | 9.59561062779463 | Inf | 7.038428913028e-10 | lineage2 | dr_mutations_pyrazinamide | THR | 0 | ERR2510690 | ERR2510690 | lineage2.2.1 | it | Italy | pnca_p.ile6thr | A | E | ILE | IA6 | pnca_complex.pdb |
324 | I6T | L2 | PZA | I | I6 | 6 | T | 1 | XDR | DM | hydrophobic | hydrophobic | non-polar | neutral | non-polar | polar | 9.258 | -1.244 | -3.089 | 3.71452 | -3.589 | -3.14 | 62 | 80 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.000646830530401 | 87.6075949367089 | 1395214.80217275 | Inf | 38.0099632572142 | 24 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 0 | -1 | 0 | -1 | 0 | 2 | 0 | 0 | 0 | -0.315096251266464 | -0.798191214470284 | 0.135290903925582 | -0.611935208866155 | -0.821989528795812 | 0.652631578947368 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | 14.148558941436 | 0.896008552350165 | 108.247901039825 | 0.130705157379733 | 226.474535586036 | NA | 1.94254175795031 | 1.23317897951184e-07 | 6.90897388676731 | 9.59561062779463 | Inf | 7.038428913028e-10 | lineage2 | dr_mutations_pyrazinamide | THR | 0 | ERR2510703 | ERR2510703 | lineage2.2.1 | it | Italy | pnca_p.ile6thr | A | E | ILE | IA6 | pnca_complex.pdb |
325 | I6T | L2 | PZA | I | I6 | 6 | T | NA | Pre-XDR | DM | hydrophobic | hydrophobic | non-polar | neutral | non-polar | polar | 9.258 | -1.244 | -3.089 | 3.71452 | -3.589 | -3.14 | 62 | 80 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.000646830530401 | 87.6075949367089 | 1395214.80217275 | Inf | 38.0099632572142 | 24 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 0 | -1 | 0 | -1 | 0 | 2 | 0 | 0 | 0 | -0.315096251266464 | -0.798191214470284 | 0.135290903925582 | -0.611935208866155 | -0.821989528795812 | 0.652631578947368 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | 14.148558941436 | 0.896008552350165 | 108.247901039825 | 0.130705157379733 | 226.474535586036 | NA | 1.94254175795031 | 1.23317897951184e-07 | 6.90897388676731 | 9.59561062779463 | Inf | 7.038428913028e-10 | lineage2 | dr_mutations_pyrazinamide | THR | 0 | SAMN02414851 | SRR1162709_SRR1166864_SRR1165553_SRR1165535 | lineage2.2.1 | se | Sweden | pnca_p.ile6thr | A | E | ILE | IA6 | pnca_complex.pdb |
326 | I6T | L2 | PZA | I | I6 | 6 | T | NA | Pre-XDR | DM | hydrophobic | hydrophobic | non-polar | neutral | non-polar | polar | 9.258 | -1.244 | -3.089 | 3.71452 | -3.589 | -3.14 | 62 | 80 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.000646830530401 | 87.6075949367089 | 1395214.80217275 | Inf | 38.0099632572142 | 24 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 0 | -1 | 0 | -1 | 0 | 2 | 0 | 0 | 0 | -0.315096251266464 | -0.798191214470284 | 0.135290903925582 | -0.611935208866155 | -0.821989528795812 | 0.652631578947368 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | 14.148558941436 | 0.896008552350165 | 108.247901039825 | 0.130705157379733 | 226.474535586036 | NA | 1.94254175795031 | 1.23317897951184e-07 | 6.90897388676731 | 9.59561062779463 | Inf | 7.038428913028e-10 | lineage2 | dr_mutations_pyrazinamide | THR | 0 | SAMN02414859 | SRR1165540_SRR1165563_SRR1162741_SRR1166932 | lineage2.2.1 | se | Sweden | pnca_p.ile6thr | A | E | ILE | IA6 | pnca_complex.pdb |
327 | I6T | L2 | PZA | I | I6 | 6 | T | 1 | MDR | DM | hydrophobic | hydrophobic | non-polar | neutral | non-polar | polar | 9.258 | -1.244 | -3.089 | 3.71452 | -3.589 | -3.14 | 62 | 80 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.000646830530401 | 87.6075949367089 | 1395214.80217275 | Inf | 38.0099632572142 | 24 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 0 | -1 | 0 | -1 | 0 | 2 | 0 | 0 | 0 | -0.315096251266464 | -0.798191214470284 | 0.135290903925582 | -0.611935208866155 | -0.821989528795812 | 0.652631578947368 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | 14.148558941436 | 0.896008552350165 | 108.247901039825 | 0.130705157379733 | 226.474535586036 | NA | 1.94254175795031 | 1.23317897951184e-07 | 6.90897388676731 | 9.59561062779463 | Inf | 7.038428913028e-10 | lineage2 | dr_mutations_pyrazinamide | THR | 0 | 1530P-sc-2011-10-12T14:58:51Z-1289115,ERR108450 | ERR108450 | lineage2.2.1 | ru | Russia,Samara | pnca_p.ile6thr | A | E | ILE | IA6 | pnca_complex.pdb |
328 | I6T | L2 | PZA | I | I6 | 6 | T | 1 | XDR | DM | hydrophobic | hydrophobic | non-polar | neutral | non-polar | polar | 9.258 | -1.244 | -3.089 | 3.71452 | -3.589 | -3.14 | 62 | 80 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.000646830530401 | 87.6075949367089 | 1395214.80217275 | Inf | 38.0099632572142 | 24 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 0 | -1 | 0 | -1 | 0 | 2 | 0 | 0 | 0 | -0.315096251266464 | -0.798191214470284 | 0.135290903925582 | -0.611935208866155 | -0.821989528795812 | 0.652631578947368 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | 14.148558941436 | 0.896008552350165 | 108.247901039825 | 0.130705157379733 | 226.474535586036 | NA | 1.94254175795031 | 1.23317897951184e-07 | 6.90897388676731 | 9.59561062779463 | Inf | 7.038428913028e-10 | lineage2 | dr_mutations_pyrazinamide | THR | 0 | ERR2510723 | ERR2510723 | lineage2.2.1 | it | Italy | pnca_p.ile6thr | A | E | ILE | IA6 | pnca_complex.pdb |
329 | I6T | L2 | PZA | I | I6 | 6 | T | 1 | XDR | DM | hydrophobic | hydrophobic | non-polar | neutral | non-polar | polar | 9.258 | -1.244 | -3.089 | 3.71452 | -3.589 | -3.14 | 62 | 80 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.000646830530401 | 87.6075949367089 | 1395214.80217275 | Inf | 38.0099632572142 | 24 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 0 | -1 | 0 | -1 | 0 | 2 | 0 | 0 | 0 | -0.315096251266464 | -0.798191214470284 | 0.135290903925582 | -0.611935208866155 | -0.821989528795812 | 0.652631578947368 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | 14.148558941436 | 0.896008552350165 | 108.247901039825 | 0.130705157379733 | 226.474535586036 | NA | 1.94254175795031 | 1.23317897951184e-07 | 6.90897388676731 | 9.59561062779463 | Inf | 7.038428913028e-10 | lineage2 | dr_mutations_pyrazinamide | THR | 0 | ERR2510709 | ERR2510709 | lineage2.2.1 | it | Italy | pnca_p.ile6thr | A | E | ILE | IA6 | pnca_complex.pdb |
330 | I6T | L2 | PZA | I | I6 | 6 | T | 1 | XDR | DM | hydrophobic | hydrophobic | non-polar | neutral | non-polar | polar | 9.258 | -1.244 | -3.089 | 3.71452 | -3.589 | -3.14 | 62 | 80 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | 0.000646830530401 | 87.6075949367089 | 1395214.80217275 | Inf | 38.0099632572142 | 24 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 0 | -1 | 0 | -1 | 0 | 2 | 0 | 0 | 0 | -0.315096251266464 | -0.798191214470284 | 0.135290903925582 | -0.611935208866155 | -0.821989528795812 | 0.652631578947368 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | 14.148558941436 | 0.896008552350165 | 108.247901039825 | 0.130705157379733 | 226.474535586036 | NA | 1.94254175795031 | 1.23317897951184e-07 | 6.90897388676731 | 9.59561062779463 | Inf | 7.038428913028e-10 | lineage2 | dr_mutations_pyrazinamide | THR | 0 | ERR2510702 | ERR2510702 | lineage2.2.1 | it | Italy | pnca_p.ile6thr | A | E | ILE | IA6 | pnca_complex.pdb |
331 | I6V | L1 | PZA | I | I6 | 6 | V | NA | Sensitive | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -2.761 | -1.528 | 1.33147 | -1.511 | -1.35 | -86 | 93 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | NA | NA | NA | NA | NA | 24 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -1 | 0 | -1 | 0 | 2 | 0 | 2 | 0 | -0.699341438703141 | -0.394832041343669 | 0.048495035657311 | -0.257630008525149 | -0.353403141361257 | -0.924731182795699 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | neutral | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | lineage1 | other_mutations_pyrazinamide | VAL | 0 | SAMN02599161 | SRR1173036_SRR1172709 | lineage1.1.3 | in | India | pnca_p.ile6val | A | E | ILE | IA6 | pnca_complex.pdb |
332 | I6V | | PZA | I | I6 | 6 | V | NA | Other | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -2.761 | -1.528 | 1.33147 | -1.511 | -1.35 | -86 | 93 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | NA | NA | NA | NA | NA | 24 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -1 | 0 | -1 | 0 | 2 | 0 | 2 | 0 | -0.699341438703141 | -0.394832041343669 | 0.048495035657311 | -0.257630008525149 | -0.353403141361257 | -0.924731182795699 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | neutral | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | | other_mutations_pyrazinamide | VAL | 0 | SRR7496471 | SRR7496471 | | us | Hawaii | pnca_p.ile6val | A | E | ILE | IA6 | pnca_complex.pdb |
333 | I6V | L4 | PZA | I | I6 | 6 | V | NA | Pre-MDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 9.258 | -2.761 | -1.528 | 1.33147 | -1.511 | -1.35 | -86 | 93 | -0.6 | 7 | 7 | 1 | 0.0050761421319796 | strand | 4.4 | 11.36 | NA | NA | NA | NA | NA | 24 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -1 | 0 | -1 | 0 | 2 | 0 | 2 | 0 | -0.699341438703141 | -0.394832041343669 | 0.048495035657311 | -0.257630008525149 | -0.353403141361257 | -0.924731182795699 | -0.494233937397035 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | neutral | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | lineage4 | other_mutations_pyrazinamide | VAL | 0 | SRR7496523 | SRR7496523 | lineage4 | us | Hawaii | pnca_p.ile6val | A | E | ILE | IA6 | pnca_complex.pdb |
334 | V7A | L4 | PZA | V | V7 | 7 | A | NA | Other | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 5.336 | -0.97 | -2.592 | 3.42668 | -3.043 | -1.9 | 64 | 80 | -0.66 | 7 | 7 | 0 | 0 | strand | 1.73333333333333 | 11.02 | 7.18700589334483e-05 | 2.42412778478352 | 0.0001249735077034 | 0 | 1.03410070803344e-29 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 0 | 5 | 0 | 3 | 2 | 4 | 0 | 6 | 3 | -0.245694022289767 | -0.669767441860465 | 0.124807144574188 | -0.518840579710145 | -0.49738219895288 | 0.673684210526316 | -0.543657331136738 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.779 | -0.615 | 8:7 | 146/150 | V:I:A | -8.98740878149641 | 0.940032862253633 | 119.468044435491 | -0.075228558598775 | NA | 4692673.51081185 | 0.384555509373631 | 1 | 0 | 0 | 188.544222231268 | 0.999999999999997 | lineage4 | other_mutations_pyrazinamide | ALA | 0 | ERR2229336 | ERR2229336 | lineage4.8 | dk | | pnca_p.val7ala | A | E | VAL | VA7 | pnca_complex.pdb |
335 | V7A | L2 | PZA | V | V7 | 7 | A | NA | XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 5.336 | -0.97 | -2.592 | 3.42668 | -3.043 | -1.9 | 64 | 80 | -0.66 | 7 | 7 | 0 | 0 | strand | 1.73333333333333 | 11.02 | 7.18700589334483e-05 | 2.42412778478352 | 0.0001249735077034 | 0 | 1.03410070803344e-29 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 0 | 5 | 0 | 3 | 2 | 4 | 0 | 6 | 3 | -0.245694022289767 | -0.669767441860465 | 0.124807144574188 | -0.518840579710145 | -0.49738219895288 | 0.673684210526316 | -0.543657331136738 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.779 | -0.615 | 8:7 | 146/150 | V:I:A | -8.98740878149641 | 0.940032862253633 | 119.468044435491 | -0.075228558598775 | NA | 4692673.51081185 | 0.384555509373631 | 1 | 0 | 0 | 188.544222231268 | 0.999999999999997 | lineage2 | other_mutations_pyrazinamide | ALA | 0 | SRR5266560 | SRR5266560 | lineage2.2.1 | ru | Russia | pnca_p.val7ala | A | E | VAL | VA7 | pnca_complex.pdb |
336 | V7A | L2 | PZA | V | V7 | 7 | A | NA | XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 5.336 | -0.97 | -2.592 | 3.42668 | -3.043 | -1.9 | 64 | 80 | -0.66 | 7 | 7 | 0 | 0 | strand | 1.73333333333333 | 11.02 | 7.18700589334483e-05 | 2.42412778478352 | 0.0001249735077034 | 0 | 1.03410070803344e-29 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 0 | 5 | 0 | 3 | 2 | 4 | 0 | 6 | 3 | -0.245694022289767 | -0.669767441860465 | 0.124807144574188 | -0.518840579710145 | -0.49738219895288 | 0.673684210526316 | -0.543657331136738 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.779 | -0.615 | 8:7 | 146/150 | V:I:A | -8.98740878149641 | 0.940032862253633 | 119.468044435491 | -0.075228558598775 | NA | 4692673.51081185 | 0.384555509373631 | 1 | 0 | 0 | 188.544222231268 | 0.999999999999997 | lineage2 | other_mutations_pyrazinamide | ALA | 0 | ETB0089 | SRR6257033 | lineage2.2.1 | ru | Russia:Leningrad Region | pnca_p.val7ala | A | E | VAL | VA7 | pnca_complex.pdb |
337 | V7A | L2 | PZA | V | V7 | 7 | A | NA | XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 5.336 | -0.97 | -2.592 | 3.42668 | -3.043 | -1.9 | 64 | 80 | -0.66 | 7 | 7 | 0 | 0 | strand | 1.73333333333333 | 11.02 | 7.18700589334483e-05 | 2.42412778478352 | 0.0001249735077034 | 0 | 1.03410070803344e-29 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 0 | 5 | 0 | 3 | 2 | 4 | 0 | 6 | 3 | -0.245694022289767 | -0.669767441860465 | 0.124807144574188 | -0.518840579710145 | -0.49738219895288 | 0.673684210526316 | -0.543657331136738 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.779 | -0.615 | 8:7 | 146/150 | V:I:A | -8.98740878149641 | 0.940032862253633 | 119.468044435491 | -0.075228558598775 | NA | 4692673.51081185 | 0.384555509373631 | 1 | 0 | 0 | 188.544222231268 | 0.999999999999997 | lineage2 | other_mutations_pyrazinamide | ALA | 0 | SRR5266539 | SRR5266539 | lineage2.2.1 | ru | Russia | pnca_p.val7ala | A | E | VAL | VA7 | pnca_complex.pdb |
338 | V7A | L2 | PZA | V | V7 | 7 | A | NA | MDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 5.336 | -0.97 | -2.592 | 3.42668 | -3.043 | -1.9 | 64 | 80 | -0.66 | 7 | 7 | 0 | 0 | strand | 1.73333333333333 | 11.02 | 7.18700589334483e-05 | 2.42412778478352 | 0.0001249735077034 | 0 | 1.03410070803344e-29 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 0 | 5 | 0 | 3 | 2 | 4 | 0 | 6 | 3 | -0.245694022289767 | -0.669767441860465 | 0.124807144574188 | -0.518840579710145 | -0.49738219895288 | 0.673684210526316 | -0.543657331136738 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.779 | -0.615 | 8:7 | 146/150 | V:I:A | -8.98740878149641 | 0.940032862253633 | 119.468044435491 | -0.075228558598775 | NA | 4692673.51081185 | 0.384555509373631 | 1 | 0 | 0 | 188.544222231268 | 0.999999999999997 | lineage2 | other_mutations_pyrazinamide | ALA | 0 | ERR2516416 | ERR2516416 | lineage2.2.1.1 | nl | Netherlands | pnca_p.val7ala | A | E | VAL | VA7 | pnca_complex.pdb |
339 | V7A | L4 | PZA | V | V7 | 7 | A | NA | MDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 5.336 | -0.97 | -2.592 | 3.42668 | -3.043 | -1.9 | 64 | 80 | -0.66 | 7 | 7 | 0 | 0 | strand | 1.73333333333333 | 11.02 | 7.18700589334483e-05 | 2.42412778478352 | 0.0001249735077034 | 0 | 1.03410070803344e-29 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 0 | 5 | 0 | 3 | 2 | 4 | 0 | 6 | 3 | -0.245694022289767 | -0.669767441860465 | 0.124807144574188 | -0.518840579710145 | -0.49738219895288 | 0.673684210526316 | -0.543657331136738 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.779 | -0.615 | 8:7 | 146/150 | V:I:A | -8.98740878149641 | 0.940032862253633 | 119.468044435491 | -0.075228558598775 | NA | 4692673.51081185 | 0.384555509373631 | 1 | 0 | 0 | 188.544222231268 | 0.999999999999997 | lineage4 | other_mutations_pyrazinamide | ALA | 0 | ERR2707207 | ERR2707207 | lineage4.3.4.2 | cd | Democratic Republic of Congo | pnca_p.val7ala | A | E | VAL | VA7 | pnca_complex.pdb |
340 | V7A | L4 | PZA | V | V7 | 7 | A | NA | Pre-XDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 5.336 | -0.97 | -2.592 | 3.42668 | -3.043 | -1.9 | 64 | 80 | -0.66 | 7 | 7 | 0 | 0 | strand | 1.73333333333333 | 11.02 | 7.18700589334483e-05 | 2.42412778478352 | 0.0001249735077034 | 0 | 1.03410070803344e-29 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 0 | 5 | 0 | 3 | 2 | 4 | 0 | 6 | 3 | -0.245694022289767 | -0.669767441860465 | 0.124807144574188 | -0.518840579710145 | -0.49738219895288 | 0.673684210526316 | -0.543657331136738 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.779 | -0.615 | 8:7 | 146/150 | V:I:A | -8.98740878149641 | 0.940032862253633 | 119.468044435491 | -0.075228558598775 | NA | 4692673.51081185 | 0.384555509373631 | 1 | 0 | 0 | 188.544222231268 | 0.999999999999997 | lineage4 | other_mutations_pyrazinamide | ALA | 0 | SAMN02403510 | SRR1167309_SRR1173718_SRR1165298_SRR1173815 | lineage4.1.1.3 | za | South Africa | pnca_p.val7ala | A | E | VAL | VA7 | pnca_complex.pdb |
341 | V7A | L2 | PZA | V | V7 | 7 | A | 0 | MDR | OM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 5.336 | -0.97 | -2.592 | 3.42668 | -3.043 | -1.9 | 64 | 80 | -0.66 | 7 | 7 | 0 | 0 | strand | 1.73333333333333 | 11.02 | 7.18700589334483e-05 | 2.42412778478352 | 0.0001249735077034 | 0 | 1.03410070803344e-29 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 0 | 5 | 0 | 3 | 2 | 4 | 0 | 6 | 3 | -0.245694022289767 | -0.669767441860465 | 0.124807144574188 | -0.518840579710145 | -0.49738219895288 | 0.673684210526316 | -0.543657331136738 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.779 | -0.615 | 8:7 | 146/150 | V:I:A | -8.98740878149641 | 0.940032862253633 | 119.468044435491 | -0.075228558598775 | NA | 4692673.51081185 | 0.384555509373631 | 1 | 0 | 0 | 188.544222231268 | 0.999999999999997 | lineage2 | other_mutations_pyrazinamide | ALA | 0 | ERR2516577 | ERR2516577 | lineage2.2.1.1 | nl | Netherlands | pnca_p.val7ala | A | E | VAL | VA7 | pnca_complex.pdb |
342 | V7F | L2 | PZA | V | V7 | 7 | F | 1 | Pre-XDR | DM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 5.336 | 0.042 | -1.877 | 4.86315 | -2.949 | -1.55 | 83 | 91 | -0.66 | 7 | 7 | 0 | 0 | strand | 1.73333333333333 | 11.02 | 0.0002156101768003 | 9.70466975178797 | 9.70465898653049 | 9.70194990589383 | 2.29168245016684 | -54 | -2 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 0 | -3 | 0 | 1 | -4 | -8 | 0 | -6 | -4 | 0.0188340807174887 | -0.485012919896641 | 0.177126508788671 | -0.502813299232737 | -0.405759162303665 | 0.873684210526316 | -0.543657331136738 | Stabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.779 | -0.615 | 8:7 | 146/150 | V:I:A | 2.27260607808817 | 0.06344559022609 | 1.22442760158496 | 1.8560559033024 | 0.929172866365903 | 208.881603004777 | 0.986980761010679 | 0.0776844925942494 | 1.10966566656461 | 0.504888890842109 | 570.372842410328 | 0.130068862702538 | lineage2 | dr_mutations_pyrazinamide | PHE | 0 | ERR2510561 | ERR2510561 | lineage2.2.1 | pk | Pakistan | pnca_p.val7phe | A | E | VAL | VA7 | pnca_complex.pdb |
343 | V7F | L4 | PZA | V | V7 | 7 | F | 0 | Pre-XDR | DM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 5.336 | 0.042 | -1.877 | 4.86315 | -2.949 | -1.55 | 83 | 91 | -0.66 | 7 | 7 | 0 | 0 | strand | 1.73333333333333 | 11.02 | 0.0002156101768003 | 9.70466975178797 | 9.70465898653049 | 9.70194990589383 | 2.29168245016684 | -54 | -2 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 0 | -3 | 0 | 1 | -4 | -8 | 0 | -6 | -4 | 0.0188340807174887 | -0.485012919896641 | 0.177126508788671 | -0.502813299232737 | -0.405759162303665 | 0.873684210526316 | -0.543657331136738 | Stabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.779 | -0.615 | 8:7 | 146/150 | V:I:A | 2.27260607808817 | 0.06344559022609 | 1.22442760158496 | 1.8560559033024 | 0.929172866365903 | 208.881603004777 | 0.986980761010679 | 0.0776844925942494 | 1.10966566656461 | 0.504888890842109 | 570.372842410328 | 0.130068862702538 | lineage4 | dr_mutations_pyrazinamide | PHE | 0 | ERR2510453 | ERR2510453 | lineage4.8 | pk | Pakistan | pnca_p.val7phe | A | E | VAL | VA7 | pnca_complex.pdb |
344 | V7F | L2 | PZA | V | V7 | 7 | F | NA | XDR | DM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 5.336 | 0.042 | -1.877 | 4.86315 | -2.949 | -1.55 | 83 | 91 | -0.66 | 7 | 7 | 0 | 0 | strand | 1.73333333333333 | 11.02 | 0.0002156101768003 | 9.70466975178797 | 9.70465898653049 | 9.70194990589383 | 2.29168245016684 | -54 | -2 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 0 | -3 | 0 | 1 | -4 | -8 | 0 | -6 | -4 | 0.0188340807174887 | -0.485012919896641 | 0.177126508788671 | -0.502813299232737 | -0.405759162303665 | 0.873684210526316 | -0.543657331136738 | Stabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.779 | -0.615 | 8:7 | 146/150 | V:I:A | 2.27260607808817 | 0.06344559022609 | 1.22442760158496 | 1.8560559033024 | 0.929172866365903 | 208.881603004777 | 0.986980761010679 | 0.0776844925942494 | 1.10966566656461 | 0.504888890842109 | 570.372842410328 | 0.130068862702538 | lineage2 | dr_mutations_pyrazinamide | PHE | 0 | SRR671815,BGI_SH311 | SRR671815 | lineage2.2.1 | cn | China | pnca_p.val7phe | A | E | VAL | VA7 | pnca_complex.pdb |
345 | V7F | L4 | PZA | V | V7 | 7 | F | 1 | Pre-XDR | DM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 5.336 | 0.042 | -1.877 | 4.86315 | -2.949 | -1.55 | 83 | 91 | -0.66 | 7 | 7 | 0 | 0 | strand | 1.73333333333333 | 11.02 | 0.0002156101768003 | 9.70466975178797 | 9.70465898653049 | 9.70194990589383 | 2.29168245016684 | -54 | -2 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 0 | -3 | 0 | 1 | -4 | -8 | 0 | -6 | -4 | 0.0188340807174887 | -0.485012919896641 | 0.177126508788671 | -0.502813299232737 | -0.405759162303665 | 0.873684210526316 | -0.543657331136738 | Stabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.779 | -0.615 | 8:7 | 146/150 | V:I:A | 2.27260607808817 | 0.06344559022609 | 1.22442760158496 | 1.8560559033024 | 0.929172866365903 | 208.881603004777 | 0.986980761010679 | 0.0776844925942494 | 1.10966566656461 | 0.504888890842109 | 570.372842410328 | 0.130068862702538 | lineage4 | dr_mutations_pyrazinamide | PHE | 0 | ERR2516523 | ERR2516523 | lineage4.1.1 | pe | Peru | pnca_p.val7phe | A | E | VAL | VA7 | pnca_complex.pdb |
346 | V7G | L2 | PZA | V | V7 | 7 | G | NA | XDR | DM | hydrophobic | hydrophobic | non-polar | neutral | non-polar | non-polar | 5.336 | -1.062 | -3.114 | 5.26226 | -4.33 | -2.58 | 86 | 91 | -0.66 | 7 | 7 | 0 | 0 | strand | 1.73333333333333 | 11.02 | 0.001293661060802 | 39.0452814219213 | 39.0452813634446 | 39.0430804499264 | 60.5607562088978 | 12 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 0 | 3 | 0 | 1 | 2 | 8 | 0 | 11 | 21 | -0.268996960486322 | -0.804651162790698 | 0.191662963745365 | -0.738277919863598 | -0.675392670157068 | 0.905263157894737 | -0.543657331136738 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.779 | -0.615 | 8:7 | 146/150 | V:I:A | 3.6647220332212 | 1.03849290922087e-06 | 0.750321763717271 | 4.88420063289289 | 11.103639297077 | 247.090478887866 | 1.59156855738766 | 5.52264644232101e-11 | 10.2578527592503 | 9.16748833639401 | 349.97982252054 | 7.13421964779937e-15 | lineage2 | dr_mutations_pyrazinamide | GLY | 0 | SAMN02628499 | SRR1172711_SRR1173722 | lineage2.2.1 | ir | Iran | pnca_p.val7gly | A | E | VAL | VA7 | pnca_complex.pdb |
347 | V7G | L2 | PZA | V | V7 | 7 | G | 1 | Pre-XDR | DM | hydrophobic | hydrophobic | non-polar | neutral | non-polar | non-polar | 5.336 | -1.062 | -3.114 | 5.26226 | -4.33 | -2.58 | 86 | 91 | -0.66 | 7 | 7 | 0 | 0 | strand | 1.73333333333333 | 11.02 | 0.001293661060802 | 39.0452814219213 | 39.0452813634446 | 39.0430804499264 | 60.5607562088978 | 12 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 0 | 3 | 0 | 1 | 2 | 8 | 0 | 11 | 21 | -0.268996960486322 | -0.804651162790698 | 0.191662963745365 | -0.738277919863598 | -0.675392670157068 | 0.905263157894737 | -0.543657331136738 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.779 | -0.615 | 8:7 | 146/150 | V:I:A | 3.6647220332212 | 1.03849290922087e-06 | 0.750321763717271 | 4.88420063289289 | 11.103639297077 | 247.090478887866 | 1.59156855738766 | 5.52264644232101e-11 | 10.2578527592503 | 9.16748833639401 | 349.97982252054 | 7.13421964779937e-15 | lineage2 | dr_mutations_pyrazinamide | GLY | 0 | MDR_22242 | SRR6824593 | lineage2.2.1 | cn | China: Fengjie County, Chongqing | pnca_p.val7gly | A | E | VAL | VA7 | pnca_complex.pdb |
348 | V7G | L2 | PZA | V | V7 | 7 | G | 1 | Pre-MDR | DM | hydrophobic | hydrophobic | non-polar | neutral | non-polar | non-polar | 5.336 | -1.062 | -3.114 | 5.26226 | -4.33 | -2.58 | 86 | 91 | -0.66 | 7 | 7 | 0 | 0 | strand | 1.73333333333333 | 11.02 | 0.001293661060802 | 39.0452814219213 | 39.0452813634446 | 39.0430804499264 | 60.5607562088978 | 12 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 0 | 3 | 0 | 1 | 2 | 8 | 0 | 11 | 21 | -0.268996960486322 | -0.804651162790698 | 0.191662963745365 | -0.738277919863598 | -0.675392670157068 | 0.905263157894737 | -0.543657331136738 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.779 | -0.615 | 8:7 | 146/150 | V:I:A | 3.6647220332212 | 1.03849290922087e-06 | 0.750321763717271 | 4.88420063289289 | 11.103639297077 | 247.090478887866 | 1.59156855738766 | 5.52264644232101e-11 | 10.2578527592503 | 9.16748833639401 | 349.97982252054 | 7.13421964779937e-15 | lineage2 | dr_mutations_pyrazinamide | GLY | 0 | ERR144542,1769Z-sc-2012-02-21T11:37:21Z-1364779 | ERR144542 | lineage2.2.1 | ru | Russia,Samara | pnca_p.val7gly | A | E | VAL | VA7 | pnca_complex.pdb |
349 | V7G | L2 | PZA | V | V7 | 7 | G | 1 | MDR | DM | hydrophobic | hydrophobic | non-polar | neutral | non-polar | non-polar | 5.336 | -1.062 | -3.114 | 5.26226 | -4.33 | -2.58 | 86 | 91 | -0.66 | 7 | 7 | 0 | 0 | strand | 1.73333333333333 | 11.02 | 0.001293661060802 | 39.0452814219213 | 39.0452813634446 | 39.0430804499264 | 60.5607562088978 | 12 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 0 | 3 | 0 | 1 | 2 | 8 | 0 | 11 | 21 | -0.268996960486322 | -0.804651162790698 | 0.191662963745365 | -0.738277919863598 | -0.675392670157068 | 0.905263157894737 | -0.543657331136738 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.779 | -0.615 | 8:7 | 146/150 | V:I:A | 3.6647220332212 | 1.03849290922087e-06 | 0.750321763717271 | 4.88420063289289 | 11.103639297077 | 247.090478887866 | 1.59156855738766 | 5.52264644232101e-11 | 10.2578527592503 | 9.16748833639401 | 349.97982252054 | 7.13421964779937e-15 | lineage2 | dr_mutations_pyrazinamide | GLY | 0 | ERR2041800 | ERR2041800 | lineage2.2.1 | rs | Serbia | pnca_p.val7gly | A | E | VAL | VA7 | pnca_complex.pdb |
350 | V7G | L2 | PZA | V | V7 | 7 | G | NA | MDR | DM | hydrophobic | hydrophobic | non-polar | neutral | non-polar | non-polar | 5.336 | -1.062 | -3.114 | 5.26226 | -4.33 | -2.58 | 86 | 91 | -0.66 | 7 | 7 | 0 | 0 | strand | 1.73333333333333 | 11.02 | 0.001293661060802 | 39.0452814219213 | 39.0452813634446 | 39.0430804499264 | 60.5607562088978 | 12 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 0 | 3 | 0 | 1 | 2 | 8 | 0 | 11 | 21 | -0.268996960486322 | -0.804651162790698 | 0.191662963745365 | -0.738277919863598 | -0.675392670157068 | 0.905263157894737 | -0.543657331136738 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.779 | -0.615 | 8:7 | 146/150 | V:I:A | 3.6647220332212 | 1.03849290922087e-06 | 0.750321763717271 | 4.88420063289289 | 11.103639297077 | 247.090478887866 | 1.59156855738766 | 5.52264644232101e-11 | 10.2578527592503 | 9.16748833639401 | 349.97982252054 | 7.13421964779937e-15 | lineage2 | dr_mutations_pyrazinamide | GLY | 0 | SRR5709871 | SRR5709871 | lineage2.2.1 | th | Thailand | pnca_p.val7gly | A | E | VAL | VA7 | pnca_complex.pdb |
351 | V7G | L2 | PZA | V | V7 | 7 | G | NA | MDR | DM | hydrophobic | hydrophobic | non-polar | neutral | non-polar | non-polar | 5.336 | -1.062 | -3.114 | 5.26226 | -4.33 | -2.58 | 86 | 91 | -0.66 | 7 | 7 | 0 | 0 | strand | 1.73333333333333 | 11.02 | 0.001293661060802 | 39.0452814219213 | 39.0452813634446 | 39.0430804499264 | 60.5607562088978 | 12 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 0 | 3 | 0 | 1 | 2 | 8 | 0 | 11 | 21 | -0.268996960486322 | -0.804651162790698 | 0.191662963745365 | -0.738277919863598 | -0.675392670157068 | 0.905263157894737 | -0.543657331136738 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.779 | -0.615 | 8:7 | 146/150 | V:I:A | 3.6647220332212 | 1.03849290922087e-06 | 0.750321763717271 | 4.88420063289289 | 11.103639297077 | 247.090478887866 | 1.59156855738766 | 5.52264644232101e-11 | 10.2578527592503 | 9.16748833639401 | 349.97982252054 | 7.13421964779937e-15 | lineage2 | dr_mutations_pyrazinamide | GLY | 0 | SRS797250 | SRR1723776 | lineage2.2.1 | cn | China:Heilongjiang | pnca_p.val7gly | A | E | VAL | VA7 | pnca_complex.pdb |
352 | V7G | L2 | PZA | V | V7 | 7 | G | 1 | Pre-MDR | DM | hydrophobic | hydrophobic | non-polar | neutral | non-polar | non-polar | 5.336 | -1.062 | -3.114 | 5.26226 | -4.33 | -2.58 | 86 | 91 | -0.66 | 7 | 7 | 0 | 0 | strand | 1.73333333333333 | 11.02 | 0.001293661060802 | 39.0452814219213 | 39.0452813634446 | 39.0430804499264 | 60.5607562088978 | 12 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 0 | 3 | 0 | 1 | 2 | 8 | 0 | 11 | 21 | -0.268996960486322 | -0.804651162790698 | 0.191662963745365 | -0.738277919863598 | -0.675392670157068 | 0.905263157894737 | -0.543657331136738 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.779 | -0.615 | 8:7 | 146/150 | V:I:A | 3.6647220332212 | 1.03849290922087e-06 | 0.750321763717271 | 4.88420063289289 | 11.103639297077 | 247.090478887866 | 1.59156855738766 | 5.52264644232101e-11 | 10.2578527592503 | 9.16748833639401 | 349.97982252054 | 7.13421964779937e-15 | lineage2 | dr_mutations_pyrazinamide | GLY | 0 | 0153S-sc-2012-02-09T18:55:34Z-1355148,ERR133815 | ERR133815 | lineage2.2.1 | ru | Russia,Samara | pnca_p.val7gly | A | E | VAL | VA7 | pnca_complex.pdb |
353 | V7G | L2 | PZA | V | V7 | 7 | G | 1 | MDR | DM | hydrophobic | hydrophobic | non-polar | neutral | non-polar | non-polar | 5.336 | -1.062 | -3.114 | 5.26226 | -4.33 | -2.58 | 86 | 91 | -0.66 | 7 | 7 | 0 | 0 | strand | 1.73333333333333 | 11.02 | 0.001293661060802 | 39.0452814219213 | 39.0452813634446 | 39.0430804499264 | 60.5607562088978 | 12 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 0 | 3 | 0 | 1 | 2 | 8 | 0 | 11 | 21 | -0.268996960486322 | -0.804651162790698 | 0.191662963745365 | -0.738277919863598 | -0.675392670157068 | 0.905263157894737 | -0.543657331136738 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.779 | -0.615 | 8:7 | 146/150 | V:I:A | 3.6647220332212 | 1.03849290922087e-06 | 0.750321763717271 | 4.88420063289289 | 11.103639297077 | 247.090478887866 | 1.59156855738766 | 5.52264644232101e-11 | 10.2578527592503 | 9.16748833639401 | 349.97982252054 | 7.13421964779937e-15 | lineage2 | dr_mutations_pyrazinamide | GLY | 0 | ERR2041716 | ERR2041716 | lineage2.2.1 | rs | Serbia | pnca_p.val7gly | A | E | VAL | VA7 | pnca_complex.pdb |
354 | V7G | L2 | PZA | V | V7 | 7 | G | NA | XDR | DM | hydrophobic | hydrophobic | non-polar | neutral | non-polar | non-polar | 5.336 | -1.062 | -3.114 | 5.26226 | -4.33 | -2.58 | 86 | 91 | -0.66 | 7 | 7 | 0 | 0 | strand | 1.73333333333333 | 11.02 | 0.001293661060802 | 39.0452814219213 | 39.0452813634446 | 39.0430804499264 | 60.5607562088978 | 12 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 0 | 3 | 0 | 1 | 2 | 8 | 0 | 11 | 21 | -0.268996960486322 | -0.804651162790698 | 0.191662963745365 | -0.738277919863598 | -0.675392670157068 | 0.905263157894737 | -0.543657331136738 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.779 | -0.615 | 8:7 | 146/150 | V:I:A | 3.6647220332212 | 1.03849290922087e-06 | 0.750321763717271 | 4.88420063289289 | 11.103639297077 | 247.090478887866 | 1.59156855738766 | 5.52264644232101e-11 | 10.2578527592503 | 9.16748833639401 | 349.97982252054 | 7.13421964779937e-15 | lineage2 | dr_mutations_pyrazinamide | GLY | 0 | SAMN02628498 | SRR1173393_SRR1174307 | lineage2.2.1 | ir | Iran | pnca_p.val7gly | A | E | VAL | VA7 | pnca_complex.pdb |
355 | V7G | L2 | PZA | V | V7 | 7 | G | 1 | Pre-XDR | DM | hydrophobic | hydrophobic | non-polar | neutral | non-polar | non-polar | 5.336 | -1.062 | -3.114 | 5.26226 | -4.33 | -2.58 | 86 | 91 | -0.66 | 7 | 7 | 0 | 0 | strand | 1.73333333333333 | 11.02 | 0.001293661060802 | 39.0452814219213 | 39.0452813634446 | 39.0430804499264 | 60.5607562088978 | 12 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 0 | 3 | 0 | 1 | 2 | 8 | 0 | 11 | 21 | -0.268996960486322 | -0.804651162790698 | 0.191662963745365 | -0.738277919863598 | -0.675392670157068 | 0.905263157894737 | -0.543657331136738 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.779 | -0.615 | 8:7 | 146/150 | V:I:A | 3.6647220332212 | 1.03849290922087e-06 | 0.750321763717271 | 4.88420063289289 | 11.103639297077 | 247.090478887866 | 1.59156855738766 | 5.52264644232101e-11 | 10.2578527592503 | 9.16748833639401 | 349.97982252054 | 7.13421964779937e-15 | lineage2 | dr_mutations_pyrazinamide | GLY | 0 | ERR228043,2294V-sc-2012-10-11T13:38:29Z-1494207 | ERR228043 | lineage2.2.1 | ru | Russia,Samara | pnca_p.val7gly | A | E | VAL | VA7 | pnca_complex.pdb |
356 | V7G | L4 | PZA | V | V7 | 7 | G | NA | Pre-XDR | DM | hydrophobic | hydrophobic | non-polar | neutral | non-polar | non-polar | 5.336 | -1.062 | -3.114 | 5.26226 | -4.33 | -2.58 | 86 | 91 | -0.66 | 7 | 7 | 0 | 0 | strand | 1.73333333333333 | 11.02 | 0.001293661060802 | 39.0452814219213 | 39.0452813634446 | 39.0430804499264 | 60.5607562088978 | 12 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 0 | 3 | 0 | 1 | 2 | 8 | 0 | 11 | 21 | -0.268996960486322 | -0.804651162790698 | 0.191662963745365 | -0.738277919863598 | -0.675392670157068 | 0.905263157894737 | -0.543657331136738 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.779 | -0.615 | 8:7 | 146/150 | V:I:A | 3.6647220332212 | 1.03849290922087e-06 | 0.750321763717271 | 4.88420063289289 | 11.103639297077 | 247.090478887866 | 1.59156855738766 | 5.52264644232101e-11 | 10.2578527592503 | 9.16748833639401 | 349.97982252054 | 7.13421964779937e-15 | lineage4 | dr_mutations_pyrazinamide | GLY | 0 | SAMN02231161 | SRR1049969_SRR1049970_SRR998773_SRR998774_SRR998772_SRR998775 | lineage4.1 | ml | Mali | pnca_p.val7gly | A | E | VAL | VA7 | pnca_complex.pdb |
357 | V7G | L2 | PZA | V | V7 | 7 | G | NA | MDR | DM | hydrophobic | hydrophobic | non-polar | neutral | non-polar | non-polar | 5.336 | -1.062 | -3.114 | 5.26226 | -4.33 | -2.58 | 86 | 91 | -0.66 | 7 | 7 | 0 | 0 | strand | 1.73333333333333 | 11.02 | 0.001293661060802 | 39.0452814219213 | 39.0452813634446 | 39.0430804499264 | 60.5607562088978 | 12 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 0 | 3 | 0 | 1 | 2 | 8 | 0 | 11 | 21 | -0.268996960486322 | -0.804651162790698 | 0.191662963745365 | -0.738277919863598 | -0.675392670157068 | 0.905263157894737 | -0.543657331136738 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.779 | -0.615 | 8:7 | 146/150 | V:I:A | 3.6647220332212 | 1.03849290922087e-06 | 0.750321763717271 | 4.88420063289289 | 11.103639297077 | 247.090478887866 | 1.59156855738766 | 5.52264644232101e-11 | 10.2578527592503 | 9.16748833639401 | 349.97982252054 | 7.13421964779937e-15 | lineage2 | dr_mutations_pyrazinamide | GLY | 0 | 0738D-sc-2011-10-12T14:59:45Z-1289190,ERR117456 | ERR117456 | lineage2.2.1 | ru | Russia | pnca_p.val7gly | A | E | VAL | VA7 | pnca_complex.pdb |
358 | V7G | L2 | PZA | V | V7 | 7 | G | 1 | MDR | DM | hydrophobic | hydrophobic | non-polar | neutral | non-polar | non-polar | 5.336 | -1.062 | -3.114 | 5.26226 | -4.33 | -2.58 | 86 | 91 | -0.66 | 7 | 7 | 0 | 0 | strand | 1.73333333333333 | 11.02 | 0.001293661060802 | 39.0452814219213 | 39.0452813634446 | 39.0430804499264 | 60.5607562088978 | 12 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 0 | 3 | 0 | 1 | 2 | 8 | 0 | 11 | 21 | -0.268996960486322 | -0.804651162790698 | 0.191662963745365 | -0.738277919863598 | -0.675392670157068 | 0.905263157894737 | -0.543657331136738 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.779 | -0.615 | 8:7 | 146/150 | V:I:A | 3.6647220332212 | 1.03849290922087e-06 | 0.750321763717271 | 4.88420063289289 | 11.103639297077 | 247.090478887866 | 1.59156855738766 | 5.52264644232101e-11 | 10.2578527592503 | 9.16748833639401 | 349.97982252054 | 7.13421964779937e-15 | lineage2 | dr_mutations_pyrazinamide | GLY | 0 | ERR2200148 | ERR2200148 | lineage2.2.1 | rs | Serbia | pnca_p.val7gly | A | E | VAL | VA7 | pnca_complex.pdb |
359 | V7G | L2 | PZA | V | V7 | 7 | G | 1 | MDR | DM | hydrophobic | hydrophobic | non-polar | neutral | non-polar | non-polar | 5.336 | -1.062 | -3.114 | 5.26226 | -4.33 | -2.58 | 86 | 91 | -0.66 | 7 | 7 | 0 | 0 | strand | 1.73333333333333 | 11.02 | 0.001293661060802 | 39.0452814219213 | 39.0452813634446 | 39.0430804499264 | 60.5607562088978 | 12 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 0 | 3 | 0 | 1 | 2 | 8 | 0 | 11 | 21 | -0.268996960486322 | -0.804651162790698 | 0.191662963745365 | -0.738277919863598 | -0.675392670157068 | 0.905263157894737 | -0.543657331136738 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.779 | -0.615 | 8:7 | 146/150 | V:I:A | 3.6647220332212 | 1.03849290922087e-06 | 0.750321763717271 | 4.88420063289289 | 11.103639297077 | 247.090478887866 | 1.59156855738766 | 5.52264644232101e-11 | 10.2578527592503 | 9.16748833639401 | 349.97982252054 | 7.13421964779937e-15 | lineage2 | dr_mutations_pyrazinamide | GLY | 0 | ERR2041695 | ERR2041695 | lineage2.2.1 | rs | Serbia | pnca_p.val7gly | A | E | VAL | VA7 | pnca_complex.pdb |
360 | V7G | L4 | PZA | V | V7 | 7 | G | 1 | Pre-XDR | DM | hydrophobic | hydrophobic | non-polar | neutral | non-polar | non-polar | 5.336 | -1.062 | -3.114 | 5.26226 | -4.33 | -2.58 | 86 | 91 | -0.66 | 7 | 7 | 0 | 0 | strand | 1.73333333333333 | 11.02 | 0.001293661060802 | 39.0452814219213 | 39.0452813634446 | 39.0430804499264 | 60.5607562088978 | 12 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 0 | 3 | 0 | 1 | 2 | 8 | 0 | 11 | 21 | -0.268996960486322 | -0.804651162790698 | 0.191662963745365 | -0.738277919863598 | -0.675392670157068 | 0.905263157894737 | -0.543657331136738 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.779 | -0.615 | 8:7 | 146/150 | V:I:A | 3.6647220332212 | 1.03849290922087e-06 | 0.750321763717271 | 4.88420063289289 | 11.103639297077 | 247.090478887866 | 1.59156855738766 | 5.52264644232101e-11 | 10.2578527592503 | 9.16748833639401 | 349.97982252054 | 7.13421964779937e-15 | lineage4 | dr_mutations_pyrazinamide | GLY | 0 | ERS2592788 | ERR2677442 | lineage4.2.2.1 | de | Germany | pnca_p.val7gly | A | E | VAL | VA7 | pnca_complex.pdb |
361 | V7G | L2 | PZA | V | V7 | 7 | G | 1 | MDR | DM | hydrophobic | hydrophobic | non-polar | neutral | non-polar | non-polar | 5.336 | -1.062 | -3.114 | 5.26226 | -4.33 | -2.58 | 86 | 91 | -0.66 | 7 | 7 | 0 | 0 | strand | 1.73333333333333 | 11.02 | 0.001293661060802 | 39.0452814219213 | 39.0452813634446 | 39.0430804499264 | 60.5607562088978 | 12 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 0 | 3 | 0 | 1 | 2 | 8 | 0 | 11 | 21 | -0.268996960486322 | -0.804651162790698 | 0.191662963745365 | -0.738277919863598 | -0.675392670157068 | 0.905263157894737 | -0.543657331136738 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.779 | -0.615 | 8:7 | 146/150 | V:I:A | 3.6647220332212 | 1.03849290922087e-06 | 0.750321763717271 | 4.88420063289289 | 11.103639297077 | 247.090478887866 | 1.59156855738766 | 5.52264644232101e-11 | 10.2578527592503 | 9.16748833639401 | 349.97982252054 | 7.13421964779937e-15 | lineage2 | dr_mutations_pyrazinamide | GLY | 0 | MDR_8213 | SRR6824586 | lineage2.2.1 | cn | China: Bin County, Harbin City, Heilongjiang Province | pnca_p.val7gly | A | E | VAL | VA7 | pnca_complex.pdb |
362 | V7G | L2 | PZA | V | V7 | 7 | G | 1 | MDR | DM | hydrophobic | hydrophobic | non-polar | neutral | non-polar | non-polar | 5.336 | -1.062 | -3.114 | 5.26226 | -4.33 | -2.58 | 86 | 91 | -0.66 | 7 | 7 | 0 | 0 | strand | 1.73333333333333 | 11.02 | 0.001293661060802 | 39.0452814219213 | 39.0452813634446 | 39.0430804499264 | 60.5607562088978 | 12 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 0 | 3 | 0 | 1 | 2 | 8 | 0 | 11 | 21 | -0.268996960486322 | -0.804651162790698 | 0.191662963745365 | -0.738277919863598 | -0.675392670157068 | 0.905263157894737 | -0.543657331136738 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.779 | -0.615 | 8:7 | 146/150 | V:I:A | 3.6647220332212 | 1.03849290922087e-06 | 0.750321763717271 | 4.88420063289289 | 11.103639297077 | 247.090478887866 | 1.59156855738766 | 5.52264644232101e-11 | 10.2578527592503 | 9.16748833639401 | 349.97982252054 | 7.13421964779937e-15 | lineage2 | dr_mutations_pyrazinamide | GLY | 0 | ERR2510712 | ERR2510712 | lineage2.2.1 | it | Italy | pnca_p.val7gly | A | E | VAL | VA7 | pnca_complex.pdb |
363 | V7G | L2 | PZA | V | V7 | 7 | G | 1 | MDR | DM | hydrophobic | hydrophobic | non-polar | neutral | non-polar | non-polar | 5.336 | -1.062 | -3.114 | 5.26226 | -4.33 | -2.58 | 86 | 91 | -0.66 | 7 | 7 | 0 | 0 | strand | 1.73333333333333 | 11.02 | 0.001293661060802 | 39.0452814219213 | 39.0452813634446 | 39.0430804499264 | 60.5607562088978 | 12 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 0 | 3 | 0 | 1 | 2 | 8 | 0 | 11 | 21 | -0.268996960486322 | -0.804651162790698 | 0.191662963745365 | -0.738277919863598 | -0.675392670157068 | 0.905263157894737 | -0.543657331136738 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.779 | -0.615 | 8:7 | 146/150 | V:I:A | 3.6647220332212 | 1.03849290922087e-06 | 0.750321763717271 | 4.88420063289289 | 11.103639297077 | 247.090478887866 | 1.59156855738766 | 5.52264644232101e-11 | 10.2578527592503 | 9.16748833639401 | 349.97982252054 | 7.13421964779937e-15 | lineage2 | dr_mutations_pyrazinamide | GLY | 0 | ERR2516243 | ERR2516243 | lineage2.2.1 | be | Belgium | pnca_p.val7gly | A | E | VAL | VA7 | pnca_complex.pdb |
364 | V7G | L2 | PZA | V | V7 | 7 | G | 1 | Pre-MDR | DM | hydrophobic | hydrophobic | non-polar | neutral | non-polar | non-polar | 5.336 | -1.062 | -3.114 | 5.26226 | -4.33 | -2.58 | 86 | 91 | -0.66 | 7 | 7 | 0 | 0 | strand | 1.73333333333333 | 11.02 | 0.001293661060802 | 39.0452814219213 | 39.0452813634446 | 39.0430804499264 | 60.5607562088978 | 12 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 0 | 3 | 0 | 1 | 2 | 8 | 0 | 11 | 21 | -0.268996960486322 | -0.804651162790698 | 0.191662963745365 | -0.738277919863598 | -0.675392670157068 | 0.905263157894737 | -0.543657331136738 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.779 | -0.615 | 8:7 | 146/150 | V:I:A | 3.6647220332212 | 1.03849290922087e-06 | 0.750321763717271 | 4.88420063289289 | 11.103639297077 | 247.090478887866 | 1.59156855738766 | 5.52264644232101e-11 | 10.2578527592503 | 9.16748833639401 | 349.97982252054 | 7.13421964779937e-15 | lineage2 | dr_mutations_pyrazinamide | GLY | 0 | ERR133900,0667B-sc-2012-02-09T18:56:39Z-1355233 | ERR133900 | lineage2.2.1 | ru | Russia,Samara | pnca_p.val7gly | A | E | VAL | VA7 | pnca_complex.pdb |
365 | V7G | L2 | PZA | V | V7 | 7 | G | NA | MDR | DM | hydrophobic | hydrophobic | non-polar | neutral | non-polar | non-polar | 5.336 | -1.062 | -3.114 | 5.26226 | -4.33 | -2.58 | 86 | 91 | -0.66 | 7 | 7 | 0 | 0 | strand | 1.73333333333333 | 11.02 | 0.001293661060802 | 39.0452814219213 | 39.0452813634446 | 39.0430804499264 | 60.5607562088978 | 12 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 0 | 3 | 0 | 1 | 2 | 8 | 0 | 11 | 21 | -0.268996960486322 | -0.804651162790698 | 0.191662963745365 | -0.738277919863598 | -0.675392670157068 | 0.905263157894737 | -0.543657331136738 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.779 | -0.615 | 8:7 | 146/150 | V:I:A | 3.6647220332212 | 1.03849290922087e-06 | 0.750321763717271 | 4.88420063289289 | 11.103639297077 | 247.090478887866 | 1.59156855738766 | 5.52264644232101e-11 | 10.2578527592503 | 9.16748833639401 | 349.97982252054 | 7.13421964779937e-15 | lineage2 | dr_mutations_pyrazinamide | GLY | 0 | BGI_142,SRR671721 | SRR671721 | lineage2.2.1 | cn | China | pnca_p.val7gly | A | E | VAL | VA7 | pnca_complex.pdb |
366 | V7G | L2 | PZA | V | V7 | 7 | G | 0 | Pre-MDR | DM | hydrophobic | hydrophobic | non-polar | neutral | non-polar | non-polar | 5.336 | -1.062 | -3.114 | 5.26226 | -4.33 | -2.58 | 86 | 91 | -0.66 | 7 | 7 | 0 | 0 | strand | 1.73333333333333 | 11.02 | 0.001293661060802 | 39.0452814219213 | 39.0452813634446 | 39.0430804499264 | 60.5607562088978 | 12 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 0 | 3 | 0 | 1 | 2 | 8 | 0 | 11 | 21 | -0.268996960486322 | -0.804651162790698 | 0.191662963745365 | -0.738277919863598 | -0.675392670157068 | 0.905263157894737 | -0.543657331136738 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.779 | -0.615 | 8:7 | 146/150 | V:I:A | 3.6647220332212 | 1.03849290922087e-06 | 0.750321763717271 | 4.88420063289289 | 11.103639297077 | 247.090478887866 | 1.59156855738766 | 5.52264644232101e-11 | 10.2578527592503 | 9.16748833639401 | 349.97982252054 | 7.13421964779937e-15 | lineage2 | dr_mutations_pyrazinamide | GLY | 0 | ERR133888,0589R-sc-2012-02-09T18:56:26Z-1355221 | ERR133888 | lineage2.2.1 | ru | Russia,Samara | pnca_p.val7gly | A | E | VAL | VA7 | pnca_complex.pdb |
367 | V7G | L2 | PZA | V | V7 | 7 | G | 1 | MDR | DM | hydrophobic | hydrophobic | non-polar | neutral | non-polar | non-polar | 5.336 | -1.062 | -3.114 | 5.26226 | -4.33 | -2.58 | 86 | 91 | -0.66 | 7 | 7 | 0 | 0 | strand | 1.73333333333333 | 11.02 | 0.001293661060802 | 39.0452814219213 | 39.0452813634446 | 39.0430804499264 | 60.5607562088978 | 12 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 0 | 3 | 0 | 1 | 2 | 8 | 0 | 11 | 21 | -0.268996960486322 | -0.804651162790698 | 0.191662963745365 | -0.738277919863598 | -0.675392670157068 | 0.905263157894737 | -0.543657331136738 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.779 | -0.615 | 8:7 | 146/150 | V:I:A | 3.6647220332212 | 1.03849290922087e-06 | 0.750321763717271 | 4.88420063289289 | 11.103639297077 | 247.090478887866 | 1.59156855738766 | 5.52264644232101e-11 | 10.2578527592503 | 9.16748833639401 | 349.97982252054 | 7.13421964779937e-15 | lineage2 | dr_mutations_pyrazinamide | GLY | 0 | ERR2041704 | ERR2041704 | lineage2.2.1 | rs | Serbia | pnca_p.val7gly | A | E | VAL | VA7 | pnca_complex.pdb |
368 | V7G | L2 | PZA | V | V7 | 7 | G | NA | XDR | DM | hydrophobic | hydrophobic | non-polar | neutral | non-polar | non-polar | 5.336 | -1.062 | -3.114 | 5.26226 | -4.33 | -2.58 | 86 | 91 | -0.66 | 7 | 7 | 0 | 0 | strand | 1.73333333333333 | 11.02 | 0.001293661060802 | 39.0452814219213 | 39.0452813634446 | 39.0430804499264 | 60.5607562088978 | 12 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 0 | 3 | 0 | 1 | 2 | 8 | 0 | 11 | 21 | -0.268996960486322 | -0.804651162790698 | 0.191662963745365 | -0.738277919863598 | -0.675392670157068 | 0.905263157894737 | -0.543657331136738 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.779 | -0.615 | 8:7 | 146/150 | V:I:A | 3.6647220332212 | 1.03849290922087e-06 | 0.750321763717271 | 4.88420063289289 | 11.103639297077 | 247.090478887866 | 1.59156855738766 | 5.52264644232101e-11 | 10.2578527592503 | 9.16748833639401 | 349.97982252054 | 7.13421964779937e-15 | lineage2 | dr_mutations_pyrazinamide | GLY | 0 | ERR144591 | ERR144591 | lineage2.2.1 | ru | Russia | pnca_p.val7gly | A | E | VAL | VA7 | pnca_complex.pdb |
369 | V7G | L2 | PZA | V | V7 | 7 | G | 0 | MDR | DM | hydrophobic | hydrophobic | non-polar | neutral | non-polar | non-polar | 5.336 | -1.062 | -3.114 | 5.26226 | -4.33 | -2.58 | 86 | 91 | -0.66 | 7 | 7 | 0 | 0 | strand | 1.73333333333333 | 11.02 | 0.001293661060802 | 39.0452814219213 | 39.0452813634446 | 39.0430804499264 | 60.5607562088978 | 12 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 0 | 3 | 0 | 1 | 2 | 8 | 0 | 11 | 21 | -0.268996960486322 | -0.804651162790698 | 0.191662963745365 | -0.738277919863598 | -0.675392670157068 | 0.905263157894737 | -0.543657331136738 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.779 | -0.615 | 8:7 | 146/150 | V:I:A | 3.6647220332212 | 1.03849290922087e-06 | 0.750321763717271 | 4.88420063289289 | 11.103639297077 | 247.090478887866 | 1.59156855738766 | 5.52264644232101e-11 | 10.2578527592503 | 9.16748833639401 | 349.97982252054 | 7.13421964779937e-15 | lineage2 | dr_mutations_pyrazinamide | GLY | 0 | ERR2041685 | ERR2041685 | lineage2.2.1 | rs | Serbia | pnca_p.val7gly | A | E | VAL | VA7 | pnca_complex.pdb |
370 | V7G | L2 | PZA | V | V7 | 7 | G | 1 | MDR | DM | hydrophobic | hydrophobic | non-polar | neutral | non-polar | non-polar | 5.336 | -1.062 | -3.114 | 5.26226 | -4.33 | -2.58 | 86 | 91 | -0.66 | 7 | 7 | 0 | 0 | strand | 1.73333333333333 | 11.02 | 0.001293661060802 | 39.0452814219213 | 39.0452813634446 | 39.0430804499264 | 60.5607562088978 | 12 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 0 | 3 | 0 | 1 | 2 | 8 | 0 | 11 | 21 | -0.268996960486322 | -0.804651162790698 | 0.191662963745365 | -0.738277919863598 | -0.675392670157068 | 0.905263157894737 | -0.543657331136738 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.779 | -0.615 | 8:7 | 146/150 | V:I:A | 3.6647220332212 | 1.03849290922087e-06 | 0.750321763717271 | 4.88420063289289 | 11.103639297077 | 247.090478887866 | 1.59156855738766 | 5.52264644232101e-11 | 10.2578527592503 | 9.16748833639401 | 349.97982252054 | 7.13421964779937e-15 | lineage2 | dr_mutations_pyrazinamide | GLY | 0 | ERR2041691 | ERR2041691 | lineage2.2.1 | rs | Serbia | pnca_p.val7gly | A | E | VAL | VA7 | pnca_complex.pdb |
371 | V7G | L2 | PZA | V | V7 | 7 | G | 1 | MDR | DM | hydrophobic | hydrophobic | non-polar | neutral | non-polar | non-polar | 5.336 | -1.062 | -3.114 | 5.26226 | -4.33 | -2.58 | 86 | 91 | -0.66 | 7 | 7 | 0 | 0 | strand | 1.73333333333333 | 11.02 | 0.001293661060802 | 39.0452814219213 | 39.0452813634446 | 39.0430804499264 | 60.5607562088978 | 12 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 0 | 3 | 0 | 1 | 2 | 8 | 0 | 11 | 21 | -0.268996960486322 | -0.804651162790698 | 0.191662963745365 | -0.738277919863598 | -0.675392670157068 | 0.905263157894737 | -0.543657331136738 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.779 | -0.615 | 8:7 | 146/150 | V:I:A | 3.6647220332212 | 1.03849290922087e-06 | 0.750321763717271 | 4.88420063289289 | 11.103639297077 | 247.090478887866 | 1.59156855738766 | 5.52264644232101e-11 | 10.2578527592503 | 9.16748833639401 | 349.97982252054 | 7.13421964779937e-15 | lineage2 | dr_mutations_pyrazinamide | GLY | 0 | ERR2041706 | ERR2041706 | lineage2.2.1 | rs | Serbia | pnca_p.val7gly | A | E | VAL | VA7 | pnca_complex.pdb |
372 | V7G | L2 | PZA | V | V7 | 7 | G | NA | XDR | DM | hydrophobic | hydrophobic | non-polar | neutral | non-polar | non-polar | 5.336 | -1.062 | -3.114 | 5.26226 | -4.33 | -2.58 | 86 | 91 | -0.66 | 7 | 7 | 0 | 0 | strand | 1.73333333333333 | 11.02 | 0.001293661060802 | 39.0452814219213 | 39.0452813634446 | 39.0430804499264 | 60.5607562088978 | 12 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 0 | 3 | 0 | 1 | 2 | 8 | 0 | 11 | 21 | -0.268996960486322 | -0.804651162790698 | 0.191662963745365 | -0.738277919863598 | -0.675392670157068 | 0.905263157894737 | -0.543657331136738 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.779 | -0.615 | 8:7 | 146/150 | V:I:A | 3.6647220332212 | 1.03849290922087e-06 | 0.750321763717271 | 4.88420063289289 | 11.103639297077 | 247.090478887866 | 1.59156855738766 | 5.52264644232101e-11 | 10.2578527592503 | 9.16748833639401 | 349.97982252054 | 7.13421964779937e-15 | lineage2 | dr_mutations_pyrazinamide | GLY | 0 | SAMN02628501 | SRR1173446_SRR1173842 | lineage2.2.1 | ir | Iran | pnca_p.val7gly | A | E | VAL | VA7 | pnca_complex.pdb |
373 | V7G | L2 | PZA | V | V7 | 7 | G | NA | XDR | DM | hydrophobic | hydrophobic | non-polar | neutral | non-polar | non-polar | 5.336 | -1.062 | -3.114 | 5.26226 | -4.33 | -2.58 | 86 | 91 | -0.66 | 7 | 7 | 0 | 0 | strand | 1.73333333333333 | 11.02 | 0.001293661060802 | 39.0452814219213 | 39.0452813634446 | 39.0430804499264 | 60.5607562088978 | 12 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 0 | 3 | 0 | 1 | 2 | 8 | 0 | 11 | 21 | -0.268996960486322 | -0.804651162790698 | 0.191662963745365 | -0.738277919863598 | -0.675392670157068 | 0.905263157894737 | -0.543657331136738 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.779 | -0.615 | 8:7 | 146/150 | V:I:A | 3.6647220332212 | 1.03849290922087e-06 | 0.750321763717271 | 4.88420063289289 | 11.103639297077 | 247.090478887866 | 1.59156855738766 | 5.52264644232101e-11 | 10.2578527592503 | 9.16748833639401 | 349.97982252054 | 7.13421964779937e-15 | lineage2 | dr_mutations_pyrazinamide | GLY | 0 | SAMN02628500 | SRR1173750_SRR1173675 | lineage2.2.1 | ir | Iran | pnca_p.val7gly | A | E | VAL | VA7 | pnca_complex.pdb |
374 | V7G | L2 | PZA | V | V7 | 7 | G | NA | XDR | DM | hydrophobic | hydrophobic | non-polar | neutral | non-polar | non-polar | 5.336 | -1.062 | -3.114 | 5.26226 | -4.33 | -2.58 | 86 | 91 | -0.66 | 7 | 7 | 0 | 0 | strand | 1.73333333333333 | 11.02 | 0.001293661060802 | 39.0452814219213 | 39.0452813634446 | 39.0430804499264 | 60.5607562088978 | 12 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 0 | 3 | 0 | 1 | 2 | 8 | 0 | 11 | 21 | -0.268996960486322 | -0.804651162790698 | 0.191662963745365 | -0.738277919863598 | -0.675392670157068 | 0.905263157894737 | -0.543657331136738 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.779 | -0.615 | 8:7 | 146/150 | V:I:A | 3.6647220332212 | 1.03849290922087e-06 | 0.750321763717271 | 4.88420063289289 | 11.103639297077 | 247.090478887866 | 1.59156855738766 | 5.52264644232101e-11 | 10.2578527592503 | 9.16748833639401 | 349.97982252054 | 7.13421964779937e-15 | lineage2 | dr_mutations_pyrazinamide | GLY | 0 | SAMN02628502 | SRR1173792_SRR1173628 | lineage2.2.1 | ir | Iran | pnca_p.val7gly | A | E | VAL | VA7 | pnca_complex.pdb |
375 | V7I | L4 | PZA | V | V7 | 7 | I | NA | MDR | DM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 5.336 | -0.635 | -0.898 | -1.10338 | -0.738 | -0.73 | 46 | 71 | -0.66 | 7 | 7 | 0 | 0 | strand | 1.73333333333333 | 11.02 | NA | NA | NA | NA | NA | -24 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 0 | -4 | 0 | 2 | -7 | 0 | 0 | 2 | -2 | -0.160840932117528 | -0.232041343669251 | -0.212139506267784 | -0.125831202046036 | -0.19109947643979 | 0.484210526315789 | -0.543657331136738 | Destabilising | Destabilising | Stabilising | Destabilising | Destabilising | effect | -0.779 | -0.615 | 8:7 | 146/150 | V:I:A | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | lineage4 | dr_mutations_pyrazinamide | ILE | 0 | SAMN02586003 | SRR1196479_SRR1175056_SRR1184351_SRR1172851 | lineage4.3.4.2 | za | South Africa | pnca_p.val7ile | A | E | VAL | VA7 | pnca_complex.pdb |
376 | V7L | L4 | PZA | V | V7 | 7 | L | 1 | Pre-XDR | DM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 5.336 | -0.589 | -1.137 | -0.847275 | -2.289 | -0.99 | 83 | 91 | -0.66 | 7 | 7 | 0 | 0 | strand | 1.73333333333333 | 11.02 | 0.0009343107661348 | 10.9471518987342 | 10.9471289278841 | 10.9440461901209 | 21.4040928993518 | -26 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 0 | -3 | 0 | 1 | -4 | -2 | 0 | -2 | 2 | -0.14918946301925 | -0.293798449612403 | -0.162899907713605 | -0.390281329923274 | -0.259162303664921 | 0.873684210526316 | -0.543657331136738 | Destabilising | Destabilising | Stabilising | Destabilising | Destabilising | effect | -0.779 | -0.615 | 8:7 | 146/150 | V:I:A | 2.39307722351576 | 6.83262964849249e-05 | 0.600967660910521 | 3.98203993188257 | 3.56185012264106 | 40.4315613280321 | 1.03930114423982 | 4.53835196843674e-05 | 4.34310182576657 | 3.05117591386949 | 48.6969925271007 | 3.71976276752962e-06 | lineage4 | dr_mutations_pyrazinamide | LEU | 0 | 140603921,SAMN05276312 | SRR3675218 | lineage4.1.1.3 | gb | UK | pnca_p.val7leu | A | E | VAL | VA7 | pnca_complex.pdb |
377 | V7L | L4 | PZA | V | V7 | 7 | L | 0 | Pre-XDR | DM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 5.336 | -0.589 | -1.137 | -0.847275 | -2.289 | -0.99 | 83 | 91 | -0.66 | 7 | 7 | 0 | 0 | strand | 1.73333333333333 | 11.02 | 0.0009343107661348 | 10.9471518987342 | 10.9471289278841 | 10.9440461901209 | 21.4040928993518 | -26 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 0 | -3 | 0 | 1 | -4 | -2 | 0 | -2 | 2 | -0.14918946301925 | -0.293798449612403 | -0.162899907713605 | -0.390281329923274 | -0.259162303664921 | 0.873684210526316 | -0.543657331136738 | Destabilising | Destabilising | Stabilising | Destabilising | Destabilising | effect | -0.779 | -0.615 | 8:7 | 146/150 | V:I:A | 2.39307722351576 | 6.83262964849249e-05 | 0.600967660910521 | 3.98203993188257 | 3.56185012264106 | 40.4315613280321 | 1.03930114423982 | 4.53835196843674e-05 | 4.34310182576657 | 3.05117591386949 | 48.6969925271007 | 3.71976276752962e-06 | lineage4 | dr_mutations_pyrazinamide | LEU | 0 | ERR2514424 | ERR2514424 | lineage4.1.1.3 | gb | UK | pnca_p.val7leu | A | E | VAL | VA7 | pnca_complex.pdb |
378 | V7L | L4 | PZA | V | V7 | 7 | L | 1 | Pre-MDR | DM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 5.336 | -0.589 | -1.137 | -0.847275 | -2.289 | -0.99 | 83 | 91 | -0.66 | 7 | 7 | 0 | 0 | strand | 1.73333333333333 | 11.02 | 0.0009343107661348 | 10.9471518987342 | 10.9471289278841 | 10.9440461901209 | 21.4040928993518 | -26 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 0 | -3 | 0 | 1 | -4 | -2 | 0 | -2 | 2 | -0.14918946301925 | -0.293798449612403 | -0.162899907713605 | -0.390281329923274 | -0.259162303664921 | 0.873684210526316 | -0.543657331136738 | Destabilising | Destabilising | Stabilising | Destabilising | Destabilising | effect | -0.779 | -0.615 | 8:7 | 146/150 | V:I:A | 2.39307722351576 | 6.83262964849249e-05 | 0.600967660910521 | 3.98203993188257 | 3.56185012264106 | 40.4315613280321 | 1.03930114423982 | 4.53835196843674e-05 | 4.34310182576657 | 3.05117591386949 | 48.6969925271007 | 3.71976276752962e-06 | lineage4 | dr_mutations_pyrazinamide | LEU | 0 | SAMN03647145 | SRR2099972 | lineage4.1.1.3 | | | pnca_p.val7leu | A | E | VAL | VA7 | pnca_complex.pdb |
379 | V7L | L4 | PZA | V | V7 | 7 | L | 0 | Pre-XDR | DM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 5.336 | -0.589 | -1.137 | -0.847275 | -2.289 | -0.99 | 83 | 91 | -0.66 | 7 | 7 | 0 | 0 | strand | 1.73333333333333 | 11.02 | 0.0009343107661348 | 10.9471518987342 | 10.9471289278841 | 10.9440461901209 | 21.4040928993518 | -26 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 0 | -3 | 0 | 1 | -4 | -2 | 0 | -2 | 2 | -0.14918946301925 | -0.293798449612403 | -0.162899907713605 | -0.390281329923274 | -0.259162303664921 | 0.873684210526316 | -0.543657331136738 | Destabilising | Destabilising | Stabilising | Destabilising | Destabilising | effect | -0.779 | -0.615 | 8:7 | 146/150 | V:I:A | 2.39307722351576 | 6.83262964849249e-05 | 0.600967660910521 | 3.98203993188257 | 3.56185012264106 | 40.4315613280321 | 1.03930114423982 | 4.53835196843674e-05 | 4.34310182576657 | 3.05117591386949 | 48.6969925271007 | 3.71976276752962e-06 | lineage4 | dr_mutations_pyrazinamide | LEU | 0 | ERR2516816 | ERR2516816 | lineage4.1.1.3 | gb | UK | pnca_p.val7leu | A | E | VAL | VA7 | pnca_complex.pdb |
380 | V7L | L4 | PZA | V | V7 | 7 | L | 1 | Pre-XDR | DM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 5.336 | -0.589 | -1.137 | -0.847275 | -2.289 | -0.99 | 83 | 91 | -0.66 | 7 | 7 | 0 | 0 | strand | 1.73333333333333 | 11.02 | 0.0009343107661348 | 10.9471518987342 | 10.9471289278841 | 10.9440461901209 | 21.4040928993518 | -26 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 0 | -3 | 0 | 1 | -4 | -2 | 0 | -2 | 2 | -0.14918946301925 | -0.293798449612403 | -0.162899907713605 | -0.390281329923274 | -0.259162303664921 | 0.873684210526316 | -0.543657331136738 | Destabilising | Destabilising | Stabilising | Destabilising | Destabilising | effect | -0.779 | -0.615 | 8:7 | 146/150 | V:I:A | 2.39307722351576 | 6.83262964849249e-05 | 0.600967660910521 | 3.98203993188257 | 3.56185012264106 | 40.4315613280321 | 1.03930114423982 | 4.53835196843674e-05 | 4.34310182576657 | 3.05117591386949 | 48.6969925271007 | 3.71976276752962e-06 | lineage4 | dr_mutations_pyrazinamide | LEU | 0 | ERR2514982 | ERR2514982 | lineage4.1.1.3 | gb | UK | pnca_p.val7leu | A | E | VAL | VA7 | pnca_complex.pdb |
381 | V7L | L4 | PZA | V | V7 | 7 | L | 0 | Pre-XDR | DM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 5.336 | -0.589 | -1.137 | -0.847275 | -2.289 | -0.99 | 83 | 91 | -0.66 | 7 | 7 | 0 | 0 | strand | 1.73333333333333 | 11.02 | 0.0009343107661348 | 10.9471518987342 | 10.9471289278841 | 10.9440461901209 | 21.4040928993518 | -26 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 0 | -3 | 0 | 1 | -4 | -2 | 0 | -2 | 2 | -0.14918946301925 | -0.293798449612403 | -0.162899907713605 | -0.390281329923274 | -0.259162303664921 | 0.873684210526316 | -0.543657331136738 | Destabilising | Destabilising | Stabilising | Destabilising | Destabilising | effect | -0.779 | -0.615 | 8:7 | 146/150 | V:I:A | 2.39307722351576 | 6.83262964849249e-05 | 0.600967660910521 | 3.98203993188257 | 3.56185012264106 | 40.4315613280321 | 1.03930114423982 | 4.53835196843674e-05 | 4.34310182576657 | 3.05117591386949 | 48.6969925271007 | 3.71976276752962e-06 | lineage4 | dr_mutations_pyrazinamide | LEU | 0 | ERR2514947 | ERR2514947 | lineage4.1.1.3 | gb | UK | pnca_p.val7leu | A | E | VAL | VA7 | pnca_complex.pdb |
382 | V7L | L4 | PZA | V | V7 | 7 | L | 1 | Pre-XDR | DM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 5.336 | -0.589 | -1.137 | -0.847275 | -2.289 | -0.99 | 83 | 91 | -0.66 | 7 | 7 | 0 | 0 | strand | 1.73333333333333 | 11.02 | 0.0009343107661348 | 10.9471518987342 | 10.9471289278841 | 10.9440461901209 | 21.4040928993518 | -26 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 0 | -3 | 0 | 1 | -4 | -2 | 0 | -2 | 2 | -0.14918946301925 | -0.293798449612403 | -0.162899907713605 | -0.390281329923274 | -0.259162303664921 | 0.873684210526316 | -0.543657331136738 | Destabilising | Destabilising | Stabilising | Destabilising | Destabilising | effect | -0.779 | -0.615 | 8:7 | 146/150 | V:I:A | 2.39307722351576 | 6.83262964849249e-05 | 0.600967660910521 | 3.98203993188257 | 3.56185012264106 | 40.4315613280321 | 1.03930114423982 | 4.53835196843674e-05 | 4.34310182576657 | 3.05117591386949 | 48.6969925271007 | 3.71976276752962e-06 | lineage4 | dr_mutations_pyrazinamide | LEU | 0 | ERR2516831 | ERR2516831 | lineage4.1.1.3 | gb | UK | pnca_p.val7leu | A | E | VAL | VA7 | pnca_complex.pdb |
383 | V7L | L4 | PZA | V | V7 | 7 | L | 1 | Pre-MDR | DM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 5.336 | -0.589 | -1.137 | -0.847275 | -2.289 | -0.99 | 83 | 91 | -0.66 | 7 | 7 | 0 | 0 | strand | 1.73333333333333 | 11.02 | 0.0009343107661348 | 10.9471518987342 | 10.9471289278841 | 10.9440461901209 | 21.4040928993518 | -26 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 0 | -3 | 0 | 1 | -4 | -2 | 0 | -2 | 2 | -0.14918946301925 | -0.293798449612403 | -0.162899907713605 | -0.390281329923274 | -0.259162303664921 | 0.873684210526316 | -0.543657331136738 | Destabilising | Destabilising | Stabilising | Destabilising | Destabilising | effect | -0.779 | -0.615 | 8:7 | 146/150 | V:I:A | 2.39307722351576 | 6.83262964849249e-05 | 0.600967660910521 | 3.98203993188257 | 3.56185012264106 | 40.4315613280321 | 1.03930114423982 | 4.53835196843674e-05 | 4.34310182576657 | 3.05117591386949 | 48.6969925271007 | 3.71976276752962e-06 | lineage4 | dr_mutations_pyrazinamide | LEU | 0 | SAMN03647894,SRR2100721 | SRR2100721 | lineage4.1.1.3 | | | pnca_p.val7leu | A | E | VAL | VA7 | pnca_complex.pdb |
384 | V7L | L4 | PZA | V | V7 | 7 | L | 1 | Pre-MDR | DM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 5.336 | -0.589 | -1.137 | -0.847275 | -2.289 | -0.99 | 83 | 91 | -0.66 | 7 | 7 | 0 | 0 | strand | 1.73333333333333 | 11.02 | 0.0009343107661348 | 10.9471518987342 | 10.9471289278841 | 10.9440461901209 | 21.4040928993518 | -26 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 0 | -3 | 0 | 1 | -4 | -2 | 0 | -2 | 2 | -0.14918946301925 | -0.293798449612403 | -0.162899907713605 | -0.390281329923274 | -0.259162303664921 | 0.873684210526316 | -0.543657331136738 | Destabilising | Destabilising | Stabilising | Destabilising | Destabilising | effect | -0.779 | -0.615 | 8:7 | 146/150 | V:I:A | 2.39307722351576 | 6.83262964849249e-05 | 0.600967660910521 | 3.98203993188257 | 3.56185012264106 | 40.4315613280321 | 1.03930114423982 | 4.53835196843674e-05 | 4.34310182576657 | 3.05117591386949 | 48.6969925271007 | 3.71976276752962e-06 | lineage4 | dr_mutations_pyrazinamide | LEU | 0 | SRR2101039,SAMN03648286 | SRR2101039 | lineage4.1.1.3 | | | pnca_p.val7leu | A | E | VAL | VA7 | pnca_complex.pdb |
385 | V7L | L4 | PZA | V | V7 | 7 | L | 1 | Pre-MDR | DM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 5.336 | -0.589 | -1.137 | -0.847275 | -2.289 | -0.99 | 83 | 91 | -0.66 | 7 | 7 | 0 | 0 | strand | 1.73333333333333 | 11.02 | 0.0009343107661348 | 10.9471518987342 | 10.9471289278841 | 10.9440461901209 | 21.4040928993518 | -26 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 0 | -3 | 0 | 1 | -4 | -2 | 0 | -2 | 2 | -0.14918946301925 | -0.293798449612403 | -0.162899907713605 | -0.390281329923274 | -0.259162303664921 | 0.873684210526316 | -0.543657331136738 | Destabilising | Destabilising | Stabilising | Destabilising | Destabilising | effect | -0.779 | -0.615 | 8:7 | 146/150 | V:I:A | 2.39307722351576 | 6.83262964849249e-05 | 0.600967660910521 | 3.98203993188257 | 3.56185012264106 | 40.4315613280321 | 1.03930114423982 | 4.53835196843674e-05 | 4.34310182576657 | 3.05117591386949 | 48.6969925271007 | 3.71976276752962e-06 | lineage4 | dr_mutations_pyrazinamide | LEU | 0 | SRR2469373,SAMN04099730 | SRR2469373 | lineage4.1.1.3 | | | pnca_p.val7leu | A | E | VAL | VA7 | pnca_complex.pdb |
386 | V7L | L4 | PZA | V | V7 | 7 | L | NA | Pre-MDR | DM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 5.336 | -0.589 | -1.137 | -0.847275 | -2.289 | -0.99 | 83 | 91 | -0.66 | 7 | 7 | 0 | 0 | strand | 1.73333333333333 | 11.02 | 0.0009343107661348 | 10.9471518987342 | 10.9471289278841 | 10.9440461901209 | 21.4040928993518 | -26 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 0 | -3 | 0 | 1 | -4 | -2 | 0 | -2 | 2 | -0.14918946301925 | -0.293798449612403 | -0.162899907713605 | -0.390281329923274 | -0.259162303664921 | 0.873684210526316 | -0.543657331136738 | Destabilising | Destabilising | Stabilising | Destabilising | Destabilising | effect | -0.779 | -0.615 | 8:7 | 146/150 | V:I:A | 2.39307722351576 | 6.83262964849249e-05 | 0.600967660910521 | 3.98203993188257 | 3.56185012264106 | 40.4315613280321 | 1.03930114423982 | 4.53835196843674e-05 | 4.34310182576657 | 3.05117591386949 | 48.6969925271007 | 3.71976276752962e-06 | lineage4 | dr_mutations_pyrazinamide | LEU | 0 | SAMN04365146 | SRR3055242 | lineage4.1.1.3 | | | pnca_p.val7leu | A | E | VAL | VA7 | pnca_complex.pdb |
387 | V7L | L4 | PZA | V | V7 | 7 | L | 1 | Pre-MDR | DM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 5.336 | -0.589 | -1.137 | -0.847275 | -2.289 | -0.99 | 83 | 91 | -0.66 | 7 | 7 | 0 | 0 | strand | 1.73333333333333 | 11.02 | 0.0009343107661348 | 10.9471518987342 | 10.9471289278841 | 10.9440461901209 | 21.4040928993518 | -26 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 0 | -3 | 0 | 1 | -4 | -2 | 0 | -2 | 2 | -0.14918946301925 | -0.293798449612403 | -0.162899907713605 | -0.390281329923274 | -0.259162303664921 | 0.873684210526316 | -0.543657331136738 | Destabilising | Destabilising | Stabilising | Destabilising | Destabilising | effect | -0.779 | -0.615 | 8:7 | 146/150 | V:I:A | 2.39307722351576 | 6.83262964849249e-05 | 0.600967660910521 | 3.98203993188257 | 3.56185012264106 | 40.4315613280321 | 1.03930114423982 | 4.53835196843674e-05 | 4.34310182576657 | 3.05117591386949 | 48.6969925271007 | 3.71976276752962e-06 | lineage4 | dr_mutations_pyrazinamide | LEU | 0 | ERR2514008 | ERR2514008 | lineage4.1.1.3 | gb | UK | pnca_p.val7leu | A | E | VAL | VA7 | pnca_complex.pdb |
388 | V7L | L4 | PZA | V | V7 | 7 | L | NA | Pre-XDR | DM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 5.336 | -0.589 | -1.137 | -0.847275 | -2.289 | -0.99 | 83 | 91 | -0.66 | 7 | 7 | 0 | 0 | strand | 1.73333333333333 | 11.02 | 0.0009343107661348 | 10.9471518987342 | 10.9471289278841 | 10.9440461901209 | 21.4040928993518 | -26 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 0 | -3 | 0 | 1 | -4 | -2 | 0 | -2 | 2 | -0.14918946301925 | -0.293798449612403 | -0.162899907713605 | -0.390281329923274 | -0.259162303664921 | 0.873684210526316 | -0.543657331136738 | Destabilising | Destabilising | Stabilising | Destabilising | Destabilising | effect | -0.779 | -0.615 | 8:7 | 146/150 | V:I:A | 2.39307722351576 | 6.83262964849249e-05 | 0.600967660910521 | 3.98203993188257 | 3.56185012264106 | 40.4315613280321 | 1.03930114423982 | 4.53835196843674e-05 | 4.34310182576657 | 3.05117591386949 | 48.6969925271007 | 3.71976276752962e-06 | lineage4 | dr_mutations_pyrazinamide | LEU | 0 | ERR2513631 | ERR2513631 | lineage4.1.1.3 | gb | UK | pnca_p.val7leu | A | E | VAL | VA7 | pnca_complex.pdb |
389 | V7L | L4 | PZA | V | V7 | 7 | L | 0 | XDR | DM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 5.336 | -0.589 | -1.137 | -0.847275 | -2.289 | -0.99 | 83 | 91 | -0.66 | 7 | 7 | 0 | 0 | strand | 1.73333333333333 | 11.02 | 0.0009343107661348 | 10.9471518987342 | 10.9471289278841 | 10.9440461901209 | 21.4040928993518 | -26 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 0 | -3 | 0 | 1 | -4 | -2 | 0 | -2 | 2 | -0.14918946301925 | -0.293798449612403 | -0.162899907713605 | -0.390281329923274 | -0.259162303664921 | 0.873684210526316 | -0.543657331136738 | Destabilising | Destabilising | Stabilising | Destabilising | Destabilising | effect | -0.779 | -0.615 | 8:7 | 146/150 | V:I:A | 2.39307722351576 | 6.83262964849249e-05 | 0.600967660910521 | 3.98203993188257 | 3.56185012264106 | 40.4315613280321 | 1.03930114423982 | 4.53835196843674e-05 | 4.34310182576657 | 3.05117591386949 | 48.6969925271007 | 3.71976276752962e-06 | lineage4 | dr_mutations_pyrazinamide | LEU | 0 | ERR2513957 | ERR2513957 | lineage4.1.1.3 | gb | UK | pnca_p.val7leu | A | E | VAL | VA7 | pnca_complex.pdb |
390 | V7L | L4 | PZA | V | V7 | 7 | L | 1 | Pre-XDR | DM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 5.336 | -0.589 | -1.137 | -0.847275 | -2.289 | -0.99 | 83 | 91 | -0.66 | 7 | 7 | 0 | 0 | strand | 1.73333333333333 | 11.02 | 0.0009343107661348 | 10.9471518987342 | 10.9471289278841 | 10.9440461901209 | 21.4040928993518 | -26 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 0 | -3 | 0 | 1 | -4 | -2 | 0 | -2 | 2 | -0.14918946301925 | -0.293798449612403 | -0.162899907713605 | -0.390281329923274 | -0.259162303664921 | 0.873684210526316 | -0.543657331136738 | Destabilising | Destabilising | Stabilising | Destabilising | Destabilising | effect | -0.779 | -0.615 | 8:7 | 146/150 | V:I:A | 2.39307722351576 | 6.83262964849249e-05 | 0.600967660910521 | 3.98203993188257 | 3.56185012264106 | 40.4315613280321 | 1.03930114423982 | 4.53835196843674e-05 | 4.34310182576657 | 3.05117591386949 | 48.6969925271007 | 3.71976276752962e-06 | lineage4 | dr_mutations_pyrazinamide | LEU | 0 | 614509 | SRR5007178 | lineage4.1.1.3 | gb | United Kingdom | pnca_p.val7leu | A | E | VAL | VA7 | pnca_complex.pdb |
391 | V7L | L4 | PZA | V | V7 | 7 | L | NA | Pre-XDR | DM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 5.336 | -0.589 | -1.137 | -0.847275 | -2.289 | -0.99 | 83 | 91 | -0.66 | 7 | 7 | 0 | 0 | strand | 1.73333333333333 | 11.02 | 0.0009343107661348 | 10.9471518987342 | 10.9471289278841 | 10.9440461901209 | 21.4040928993518 | -26 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 0 | -3 | 0 | 1 | -4 | -2 | 0 | -2 | 2 | -0.14918946301925 | -0.293798449612403 | -0.162899907713605 | -0.390281329923274 | -0.259162303664921 | 0.873684210526316 | -0.543657331136738 | Destabilising | Destabilising | Stabilising | Destabilising | Destabilising | effect | -0.779 | -0.615 | 8:7 | 146/150 | V:I:A | 2.39307722351576 | 6.83262964849249e-05 | 0.600967660910521 | 3.98203993188257 | 3.56185012264106 | 40.4315613280321 | 1.03930114423982 | 4.53835196843674e-05 | 4.34310182576657 | 3.05117591386949 | 48.6969925271007 | 3.71976276752962e-06 | lineage4 | dr_mutations_pyrazinamide | LEU | 0 | SAMN07660385 | SRR6046819 | lineage4.1.1.3 | gb | UK | pnca_p.val7leu | A | E | VAL | VA7 | pnca_complex.pdb |
392 | D8A | L2 | PZA | D | D8 | 8 | A | NA | Pre-XDR | DM | hydrophilic | hydrophobic | acidic | non-polar | neg | non-polar | 3.22 | -3.268 | -0.511 | 0.541028 | -1.125 | 0.4 | 87 | 91 | -1.187 | 9 | 9 | 5 | 0.0259067357512953 | loop | 1.63333333333333 | 9.48 | 0.0001437401178668 | 19.411022297013 | 511754.463552623 | Inf | 4.73122070382274 | 26 | 36 | 0 | 0 | 36 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4 | 0 | 0 | 0 | 0 | -5 | 0 | -4 | -1 | 0 | 0 | 6 | 1 | -0.827760891590679 | -0.132041343669251 | 0.0197054174345676 | -0.191815856777494 | 0.224719101123595 | 0.91578947368421 | -0.977759472817133 | Destabilising | Destabilising | Destabilising | Destabilising | Stabilising | effect | -1.221 | -1.178 | 9:9 | 146/150 | D:H | 13.1456002256206 | 0.924803768447001 | 139.277183326572 | 0.094384449136922 | 0.0001628371344451 | NA | 1.28804840845689 | 0.0292235860951597 | 1.53426649183163 | 0.91081598550184 | Inf | 0.0296198560706035 | lineage2 | dr_mutations_pyrazinamide | ALA | 0 | SRR5709862,SAMN07236319 | SRR5709862 | lineage2.2.1 | th | Thailand | pnca_p.asp8ala | A | - | ASP | DA8 | pnca_complex.pdb |
393 | D8A | L2 | PZA | D | D8 | 8 | A | NA | Pre-MDR | DM | hydrophilic | hydrophobic | acidic | non-polar | neg | non-polar | 3.22 | -3.268 | -0.511 | 0.541028 | -1.125 | 0.4 | 87 | 91 | -1.187 | 9 | 9 | 5 | 0.0259067357512953 | loop | 1.63333333333333 | 9.48 | 0.0001437401178668 | 19.411022297013 | 511754.463552623 | Inf | 4.73122070382274 | 26 | 36 | 0 | 0 | 36 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4 | 0 | 0 | 0 | 0 | -5 | 0 | -4 | -1 | 0 | 0 | 6 | 1 | -0.827760891590679 | -0.132041343669251 | 0.0197054174345676 | -0.191815856777494 | 0.224719101123595 | 0.91578947368421 | -0.977759472817133 | Destabilising | Destabilising | Destabilising | Destabilising | Stabilising | effect | -1.221 | -1.178 | 9:9 | 146/150 | D:H | 13.1456002256206 | 0.924803768447001 | 139.277183326572 | 0.094384449136922 | 0.0001628371344451 | NA | 1.28804840845689 | 0.0292235860951597 | 1.53426649183163 | 0.91081598550184 | Inf | 0.0296198560706035 | lineage2 | dr_mutations_pyrazinamide | ALA | 0 | SRS797286 | SRR1723814_SRR1723813_SRR1723815 | lineage2.2.1 | cn | China:Anhui | pnca_p.asp8ala | A | - | ASP | DA8 | pnca_complex.pdb |
394 | D8A | L2 | PZA | D | D8 | 8 | A | 1 | MDR | DM | hydrophilic | hydrophobic | acidic | non-polar | neg | non-polar | 3.22 | -3.268 | -0.511 | 0.541028 | -1.125 | 0.4 | 87 | 91 | -1.187 | 9 | 9 | 5 | 0.0259067357512953 | loop | 1.63333333333333 | 9.48 | 0.0001437401178668 | 19.411022297013 | 511754.463552623 | Inf | 4.73122070382274 | 26 | 36 | 0 | 0 | 36 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4 | 0 | 0 | 0 | 0 | -5 | 0 | -4 | -1 | 0 | 0 | 6 | 1 | -0.827760891590679 | -0.132041343669251 | 0.0197054174345676 | -0.191815856777494 | 0.224719101123595 | 0.91578947368421 | -0.977759472817133 | Destabilising | Destabilising | Destabilising | Destabilising | Stabilising | effect | -1.221 | -1.178 | 9:9 | 146/150 | D:H | 13.1456002256206 | 0.924803768447001 | 139.277183326572 | 0.094384449136922 | 0.0001628371344451 | NA | 1.28804840845689 | 0.0292235860951597 | 1.53426649183163 | 0.91081598550184 | Inf | 0.0296198560706035 | lineage2 | dr_mutations_pyrazinamide | ALA | 0 | ERR553107 | ERR553107 | lineage2.2.1 | in | India | pnca_p.asp8ala | A | - | ASP | DA8 | pnca_complex.pdb |
395 | D8A | L2 | PZA | D | D8 | 8 | A | NA | Pre-XDR | DM | hydrophilic | hydrophobic | acidic | non-polar | neg | non-polar | 3.22 | -3.268 | -0.511 | 0.541028 | -1.125 | 0.4 | 87 | 91 | -1.187 | 9 | 9 | 5 | 0.0259067357512953 | loop | 1.63333333333333 | 9.48 | 0.0001437401178668 | 19.411022297013 | 511754.463552623 | Inf | 4.73122070382274 | 26 | 36 | 0 | 0 | 36 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4 | 0 | 0 | 0 | 0 | -5 | 0 | -4 | -1 | 0 | 0 | 6 | 1 | -0.827760891590679 | -0.132041343669251 | 0.0197054174345676 | -0.191815856777494 | 0.224719101123595 | 0.91578947368421 | -0.977759472817133 | Destabilising | Destabilising | Destabilising | Destabilising | Stabilising | effect | -1.221 | -1.178 | 9:9 | 146/150 | D:H | 13.1456002256206 | 0.924803768447001 | 139.277183326572 | 0.094384449136922 | 0.0001628371344451 | NA | 1.28804840845689 | 0.0292235860951597 | 1.53426649183163 | 0.91081598550184 | Inf | 0.0296198560706035 | lineage2 | dr_mutations_pyrazinamide | ALA | 0 | SAMN07236317,SRR5709816 | SRR5709816 | lineage2.2.1 | th | Thailand | pnca_p.asp8ala | A | - | ASP | DA8 | pnca_complex.pdb |
396 | D8A | L4 | PZA | D | D8 | 8 | A | NA | MDR | DM | hydrophilic | hydrophobic | acidic | non-polar | neg | non-polar | 3.22 | -3.268 | -0.511 | 0.541028 | -1.125 | 0.4 | 87 | 91 | -1.187 | 9 | 9 | 5 | 0.0259067357512953 | loop | 1.63333333333333 | 9.48 | 0.0001437401178668 | 19.411022297013 | 511754.463552623 | Inf | 4.73122070382274 | 26 | 36 | 0 | 0 | 36 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4 | 0 | 0 | 0 | 0 | -5 | 0 | -4 | -1 | 0 | 0 | 6 | 1 | -0.827760891590679 | -0.132041343669251 | 0.0197054174345676 | -0.191815856777494 | 0.224719101123595 | 0.91578947368421 | -0.977759472817133 | Destabilising | Destabilising | Destabilising | Destabilising | Stabilising | effect | -1.221 | -1.178 | 9:9 | 146/150 | D:H | 13.1456002256206 | 0.924803768447001 | 139.277183326572 | 0.094384449136922 | 0.0001628371344451 | NA | 1.28804840845689 | 0.0292235860951597 | 1.53426649183163 | 0.91081598550184 | Inf | 0.0296198560706035 | lineage4 | dr_mutations_pyrazinamide | ALA | 0 | ERR751520 | ERR751520 | lineage4.1.1 | pe | | pnca_p.asp8ala | A | - | ASP | DA8 | pnca_complex.pdb |
397 | D8A | L2 | PZA | D | D8 | 8 | A | 1 | Pre-MDR | DM | hydrophilic | hydrophobic | acidic | non-polar | neg | non-polar | 3.22 | -3.268 | -0.511 | 0.541028 | -1.125 | 0.4 | 87 | 91 | -1.187 | 9 | 9 | 5 | 0.0259067357512953 | loop | 1.63333333333333 | 9.48 | 0.0001437401178668 | 19.411022297013 | 511754.463552623 | Inf | 4.73122070382274 | 26 | 36 | 0 | 0 | 36 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4 | 0 | 0 | 0 | 0 | -5 | 0 | -4 | -1 | 0 | 0 | 6 | 1 | -0.827760891590679 | -0.132041343669251 | 0.0197054174345676 | -0.191815856777494 | 0.224719101123595 | 0.91578947368421 | -0.977759472817133 | Destabilising | Destabilising | Destabilising | Destabilising | Stabilising | effect | -1.221 | -1.178 | 9:9 | 146/150 | D:H | 13.1456002256206 | 0.924803768447001 | 139.277183326572 | 0.094384449136922 | 0.0001628371344451 | NA | 1.28804840845689 | 0.0292235860951597 | 1.53426649183163 | 0.91081598550184 | Inf | 0.0296198560706035 | lineage2 | dr_mutations_pyrazinamide | ALA | 0 | MDR_12448 | SRR6824632 | lineage2.2.1 | cn | China: Shou County, Lu'an City, Anhui Province | pnca_p.asp8ala | A | - | ASP | DA8 | pnca_complex.pdb |
398 | D8E | L4 | PZA | D | D8 | 8 | E | NA | Pre-XDR | DM | hydrophilic | hydrophilic | acidic | acidic | neg | neg | 3.22 | 0.012 | -0.786 | 1.90122 | -1.417 | -0.4 | 90 | 95 | -1.187 | 9 | 9 | 5 | 0.0259067357512953 | loop | 1.63333333333333 | 9.48 | 0.0002874802357337 | 14.5631313131313 | 14.5630810302278 | 14.5631012253236 | 5.81873994206135 | -24 | -28 | 0 | 0 | -28 | 0 | 0 | 0 | 0 | -2 | 0 | -2 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 2 | -1 | -8 | 0 | -10 | -6 | 0.0053811659192825 | -0.203100775193798 | 0.0692465708520604 | -0.241602728047741 | -0.104712041884817 | 0.947368421052632 | -0.977759472817133 | Stabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.221 | -1.178 | 9:9 | 146/150 | D:H | 2.67848962960141 | 0.0202679102821361 | 1.15384949648317 | 2.3213509541454 | 1.86363317860697 | 294.488177945815 | 1.16325476548539 | 0.0174140488202037 | 1.75910024233227 | 1.16837785201846 | 760.989759542733 | 0.0158563003544608 | lineage4 | dr_mutations_pyrazinamide | GLU | 0 | ERR2510171 | ERR2510171 | lineage4 | pe | Peru | pnca_p.asp8glu | A | - | ASP | DA8 | pnca_complex.pdb |
399 | D8E | L2 | PZA | D | D8 | 8 | E | 1 | MDR | DM | hydrophilic | hydrophilic | acidic | acidic | neg | neg | 3.22 | 0.012 | -0.786 | 1.90122 | -1.417 | -0.4 | 90 | 95 | -1.187 | 9 | 9 | 5 | 0.0259067357512953 | loop | 1.63333333333333 | 9.48 | 0.0002874802357337 | 14.5631313131313 | 14.5630810302278 | 14.5631012253236 | 5.81873994206135 | -24 | -28 | 0 | 0 | -28 | 0 | 0 | 0 | 0 | -2 | 0 | -2 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 2 | -1 | -8 | 0 | -10 | -6 | 0.0053811659192825 | -0.203100775193798 | 0.0692465708520604 | -0.241602728047741 | -0.104712041884817 | 0.947368421052632 | -0.977759472817133 | Stabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.221 | -1.178 | 9:9 | 146/150 | D:H | 2.67848962960141 | 0.0202679102821361 | 1.15384949648317 | 2.3213509541454 | 1.86363317860697 | 294.488177945815 | 1.16325476548539 | 0.0174140488202037 | 1.75910024233227 | 1.16837785201846 | 760.989759542733 | 0.0158563003544608 | lineage2 | dr_mutations_pyrazinamide | GLU | 0 | ERR108421,1052V-sc-2011-10-12T14:58:09Z-1289086 | ERR108421 | lineage2.2.1 | ru | Russia,Samara | pnca_p.asp8glu | A | - | ASP | DA8 | pnca_complex.pdb |
400 | D8E | L2 | PZA | D | D8 | 8 | E | NA | MDR | DM | hydrophilic | hydrophilic | acidic | acidic | neg | neg | 3.22 | 0.012 | -0.786 | 1.90122 | -1.417 | -0.4 | 90 | 95 | -1.187 | 9 | 9 | 5 | 0.0259067357512953 | loop | 1.63333333333333 | 9.48 | 0.0002874802357337 | 14.5631313131313 | 14.5630810302278 | 14.5631012253236 | 5.81873994206135 | -24 | -28 | 0 | 0 | -28 | 0 | 0 | 0 | 0 | -2 | 0 | -2 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 2 | -1 | -8 | 0 | -10 | -6 | 0.0053811659192825 | -0.203100775193798 | 0.0692465708520604 | -0.241602728047741 | -0.104712041884817 | 0.947368421052632 | -0.977759472817133 | Stabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.221 | -1.178 | 9:9 | 146/150 | D:H | 2.67848962960141 | 0.0202679102821361 | 1.15384949648317 | 2.3213509541454 | 1.86363317860697 | 294.488177945815 | 1.16325476548539 | 0.0174140488202037 | 1.75910024233227 | 1.16837785201846 | 760.989759542733 | 0.0158563003544608 | lineage2 | dr_mutations_pyrazinamide | GLU | 0 | ERR108477 | ERR108477 | lineage2.2.1 | ru | Russia | pnca_p.asp8glu | A | - | ASP | DA8 | pnca_complex.pdb |
401 | D8E | L4 | PZA | D | D8 | 8 | E | NA | Pre-XDR | DM | hydrophilic | hydrophilic | acidic | acidic | neg | neg | 3.22 | 0.012 | -0.786 | 1.90122 | -1.417 | -0.4 | 90 | 95 | -1.187 | 9 | 9 | 5 | 0.0259067357512953 | loop | 1.63333333333333 | 9.48 | 0.0002874802357337 | 14.5631313131313 | 14.5630810302278 | 14.5631012253236 | 5.81873994206135 | -24 | -28 | 0 | 0 | -28 | 0 | 0 | 0 | 0 | -2 | 0 | -2 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 2 | -1 | -8 | 0 | -10 | -6 | 0.0053811659192825 | -0.203100775193798 | 0.0692465708520604 | -0.241602728047741 | -0.104712041884817 | 0.947368421052632 | -0.977759472817133 | Stabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.221 | -1.178 | 9:9 | 146/150 | D:H | 2.67848962960141 | 0.0202679102821361 | 1.15384949648317 | 2.3213509541454 | 1.86363317860697 | 294.488177945815 | 1.16325476548539 | 0.0174140488202037 | 1.75910024233227 | 1.16837785201846 | 760.989759542733 | 0.0158563003544608 | lineage4 | dr_mutations_pyrazinamide | GLU | 0 | ERR775389 | ERR775389 | lineage4 | pe | | pnca_p.asp8glu | A | - | ASP | DA8 | pnca_complex.pdb |
402 | D8E | L4 | PZA | D | D8 | 8 | E | NA | Pre-XDR | DM | hydrophilic | hydrophilic | acidic | acidic | neg | neg | 3.22 | 0.012 | -0.786 | 1.90122 | -1.417 | -0.4 | 90 | 95 | -1.187 | 9 | 9 | 5 | 0.0259067357512953 | loop | 1.63333333333333 | 9.48 | 0.0002874802357337 | 14.5631313131313 | 14.5630810302278 | 14.5631012253236 | 5.81873994206135 | -24 | -28 | 0 | 0 | -28 | 0 | 0 | 0 | 0 | -2 | 0 | -2 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 2 | -1 | -8 | 0 | -10 | -6 | 0.0053811659192825 | -0.203100775193798 | 0.0692465708520604 | -0.241602728047741 | -0.104712041884817 | 0.947368421052632 | -0.977759472817133 | Stabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.221 | -1.178 | 9:9 | 146/150 | D:H | 2.67848962960141 | 0.0202679102821361 | 1.15384949648317 | 2.3213509541454 | 1.86363317860697 | 294.488177945815 | 1.16325476548539 | 0.0174140488202037 | 1.75910024233227 | 1.16837785201846 | 760.989759542733 | 0.0158563003544608 | lineage4 | dr_mutations_pyrazinamide | GLU | 0 | ERR1034831 | ERR1034831 | lineage4.3.4.1 | pt | Portugal | pnca_p.asp8glu | A | - | ASP | DA8 | pnca_complex.pdb |
403 | D8E | L2 | PZA | D | D8 | 8 | E | 1 | MDR | DM | hydrophilic | hydrophilic | acidic | acidic | neg | neg | 3.22 | 0.012 | -0.786 | 1.90122 | -1.417 | -0.4 | 90 | 95 | -1.187 | 9 | 9 | 5 | 0.0259067357512953 | loop | 1.63333333333333 | 9.48 | 0.0002874802357337 | 14.5631313131313 | 14.5630810302278 | 14.5631012253236 | 5.81873994206135 | -24 | -28 | 0 | 0 | -28 | 0 | 0 | 0 | 0 | -2 | 0 | -2 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 2 | -1 | -8 | 0 | -10 | -6 | 0.0053811659192825 | -0.203100775193798 | 0.0692465708520604 | -0.241602728047741 | -0.104712041884817 | 0.947368421052632 | -0.977759472817133 | Stabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.221 | -1.178 | 9:9 | 146/150 | D:H | 2.67848962960141 | 0.0202679102821361 | 1.15384949648317 | 2.3213509541454 | 1.86363317860697 | 294.488177945815 | 1.16325476548539 | 0.0174140488202037 | 1.75910024233227 | 1.16837785201846 | 760.989759542733 | 0.0158563003544608 | lineage2 | dr_mutations_pyrazinamide | GLU | 0 | ERR2510862 | ERR2510862 | lineage2.2.1 | it | Italy | pnca_p.asp8glu | A | - | ASP | DA8 | pnca_complex.pdb |
404 | D8E | L2 | PZA | D | D8 | 8 | E | 0 | MDR | DM | hydrophilic | hydrophilic | acidic | acidic | neg | neg | 3.22 | 0.012 | -0.786 | 1.90122 | -1.417 | -0.4 | 90 | 95 | -1.187 | 9 | 9 | 5 | 0.0259067357512953 | loop | 1.63333333333333 | 9.48 | 0.0002874802357337 | 14.5631313131313 | 14.5630810302278 | 14.5631012253236 | 5.81873994206135 | -24 | -28 | 0 | 0 | -28 | 0 | 0 | 0 | 0 | -2 | 0 | -2 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 2 | -1 | -8 | 0 | -10 | -6 | 0.0053811659192825 | -0.203100775193798 | 0.0692465708520604 | -0.241602728047741 | -0.104712041884817 | 0.947368421052632 | -0.977759472817133 | Stabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.221 | -1.178 | 9:9 | 146/150 | D:H | 2.67848962960141 | 0.0202679102821361 | 1.15384949648317 | 2.3213509541454 | 1.86363317860697 | 294.488177945815 | 1.16325476548539 | 0.0174140488202037 | 1.75910024233227 | 1.16837785201846 | 760.989759542733 | 0.0158563003544608 | lineage2 | dr_mutations_pyrazinamide | GLU | 0 | ERR553238,SAMEA2535237 | ERR553238 | lineage2.2.1 | | | pnca_p.asp8glu | A | - | ASP | DA8 | pnca_complex.pdb |
405 | D8E | L4 | PZA | D | D8 | 8 | E | NA | MDR | DM | hydrophilic | hydrophilic | acidic | acidic | neg | neg | 3.22 | 0.012 | -0.786 | 1.90122 | -1.417 | -0.4 | 90 | 95 | -1.187 | 9 | 9 | 5 | 0.0259067357512953 | loop | 1.63333333333333 | 9.48 | 0.0002874802357337 | 14.5631313131313 | 14.5630810302278 | 14.5631012253236 | 5.81873994206135 | -24 | -28 | 0 | 0 | -28 | 0 | 0 | 0 | 0 | -2 | 0 | -2 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 2 | -1 | -8 | 0 | -10 | -6 | 0.0053811659192825 | -0.203100775193798 | 0.0692465708520604 | -0.241602728047741 | -0.104712041884817 | 0.947368421052632 | -0.977759472817133 | Stabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.221 | -1.178 | 9:9 | 146/150 | D:H | 2.67848962960141 | 0.0202679102821361 | 1.15384949648317 | 2.3213509541454 | 1.86363317860697 | 294.488177945815 | 1.16325476548539 | 0.0174140488202037 | 1.75910024233227 | 1.16837785201846 | 760.989759542733 | 0.0158563003544608 | lineage4 | dr_mutations_pyrazinamide | GLU | 0 | ERR2707214 | ERR2707214 | lineage4.1.1 | cd | Democratic Republic of Congo | pnca_p.asp8glu | A | - | ASP | DA8 | pnca_complex.pdb |
406 | D8E | L4 | PZA | D | D8 | 8 | E | NA | Pre-XDR | DM | hydrophilic | hydrophilic | acidic | acidic | neg | neg | 3.22 | 0.012 | -0.786 | 1.90122 | -1.417 | -0.4 | 90 | 95 | -1.187 | 9 | 9 | 5 | 0.0259067357512953 | loop | 1.63333333333333 | 9.48 | 0.0002874802357337 | 14.5631313131313 | 14.5630810302278 | 14.5631012253236 | 5.81873994206135 | -24 | -28 | 0 | 0 | -28 | 0 | 0 | 0 | 0 | -2 | 0 | -2 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 2 | -1 | -8 | 0 | -10 | -6 | 0.0053811659192825 | -0.203100775193798 | 0.0692465708520604 | -0.241602728047741 | -0.104712041884817 | 0.947368421052632 | -0.977759472817133 | Stabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.221 | -1.178 | 9:9 | 146/150 | D:H | 2.67848962960141 | 0.0202679102821361 | 1.15384949648317 | 2.3213509541454 | 1.86363317860697 | 294.488177945815 | 1.16325476548539 | 0.0174140488202037 | 1.75910024233227 | 1.16837785201846 | 760.989759542733 | 0.0158563003544608 | lineage4 | dr_mutations_pyrazinamide | GLU | 0 | ERR845936 | ERR845936 | lineage4 | pe | | pnca_p.asp8glu | A | - | ASP | DA8 | pnca_complex.pdb |
407 | D8E | L2 | PZA | D | D8 | 8 | E | 1 | Pre-XDR | DM | hydrophilic | hydrophilic | acidic | acidic | neg | neg | 3.22 | 0.012 | -0.786 | 1.90122 | -1.417 | -0.4 | 90 | 95 | -1.187 | 9 | 9 | 5 | 0.0259067357512953 | loop | 1.63333333333333 | 9.48 | 0.0002874802357337 | 14.5631313131313 | 14.5630810302278 | 14.5631012253236 | 5.81873994206135 | -24 | -28 | 0 | 0 | -28 | 0 | 0 | 0 | 0 | -2 | 0 | -2 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 2 | -1 | -8 | 0 | -10 | -6 | 0.0053811659192825 | -0.203100775193798 | 0.0692465708520604 | -0.241602728047741 | -0.104712041884817 | 0.947368421052632 | -0.977759472817133 | Stabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.221 | -1.178 | 9:9 | 146/150 | D:H | 2.67848962960141 | 0.0202679102821361 | 1.15384949648317 | 2.3213509541454 | 1.86363317860697 | 294.488177945815 | 1.16325476548539 | 0.0174140488202037 | 1.75910024233227 | 1.16837785201846 | 760.989759542733 | 0.0158563003544608 | lineage2 | dr_mutations_pyrazinamide | GLU | 0 | ERR117454,0710Y-sc-2011-10-12T14:59:44Z-1289188 | ERR117454 | lineage2.2.1 | ru | Russia,Samara | pnca_p.asp8glu | A | - | ASP | DA8 | pnca_complex.pdb |
408 | D8G | L2;L4 | PZA | D | D8 | 8 | G | NA | MDR | DM | hydrophilic | hydrophobic | acidic | neutral | neg | non-polar | 3.22 | -3.445 | -0.851 | 1.89305 | -1.078 | -0.82 | 92 | 95 | -1.187 | 9 | 9 | 5 | 0.0259067357512953 | loop | 1.63333333333333 | 9.48 | 0.0007905706482679 | 48.6872097931617 | 48.6872048041474 | 48.6746878162623 | 37.2619168572472 | 34 | 38 | 0 | 0 | 38 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -8 | -1 | -3 | -5 | 6 | 0 | 9 | 17 | -0.872593718338399 | -0.219896640826873 | 0.0689490016681357 | -0.183802216538789 | -0.214659685863874 | 0.968421052631579 | -0.977759472817133 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.221 | -1.178 | 9:9 | 146/150 | D:H | 3.88541626053988 | 0.0002118075877291 | 1.0488367141091 | 3.70450062271154 | 9.3197738725557 | 893.78337229237 | 1.68741488635211 | 1.95392414212297e-07 | 6.70909230105579 | 6.91781679568266 | 2088.84994220519 | 1.03281930722422e-09 | lineage2;lineage4 | dr_mutations_pyrazinamide | GLY | 0 | SRR5818641 | SRR5818641 | lineage4;lineage2.2.1 | dj | Djibouti | pnca_p.asp8gly | A | - | ASP | DA8 | pnca_complex.pdb |
409 | D8G | L2 | PZA | D | D8 | 8 | G | 1 | Pre-XDR | DM | hydrophilic | hydrophobic | acidic | neutral | neg | non-polar | 3.22 | -3.445 | -0.851 | 1.89305 | -1.078 | -0.82 | 92 | 95 | -1.187 | 9 | 9 | 5 | 0.0259067357512953 | loop | 1.63333333333333 | 9.48 | 0.0007905706482679 | 48.6872097931617 | 48.6872048041474 | 48.6746878162623 | 37.2619168572472 | 34 | 38 | 0 | 0 | 38 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -8 | -1 | -3 | -5 | 6 | 0 | 9 | 17 | -0.872593718338399 | -0.219896640826873 | 0.0689490016681357 | -0.183802216538789 | -0.214659685863874 | 0.968421052631579 | -0.977759472817133 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.221 | -1.178 | 9:9 | 146/150 | D:H | 3.88541626053988 | 0.0002118075877291 | 1.0488367141091 | 3.70450062271154 | 9.3197738725557 | 893.78337229237 | 1.68741488635211 | 1.95392414212297e-07 | 6.70909230105579 | 6.91781679568266 | 2088.84994220519 | 1.03281930722422e-09 | lineage2 | dr_mutations_pyrazinamide | GLY | 0 | ERS2592737 | ERR2677386 | lineage2.2.1 | de | Germany | pnca_p.asp8gly | A | - | ASP | DA8 | pnca_complex.pdb |
410 | D8G | L2 | PZA | D | D8 | 8 | G | 1 | MDR | DM | hydrophilic | hydrophobic | acidic | neutral | neg | non-polar | 3.22 | -3.445 | -0.851 | 1.89305 | -1.078 | -0.82 | 92 | 95 | -1.187 | 9 | 9 | 5 | 0.0259067357512953 | loop | 1.63333333333333 | 9.48 | 0.0007905706482679 | 48.6872097931617 | 48.6872048041474 | 48.6746878162623 | 37.2619168572472 | 34 | 38 | 0 | 0 | 38 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -8 | -1 | -3 | -5 | 6 | 0 | 9 | 17 | -0.872593718338399 | -0.219896640826873 | 0.0689490016681357 | -0.183802216538789 | -0.214659685863874 | 0.968421052631579 | -0.977759472817133 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.221 | -1.178 | 9:9 | 146/150 | D:H | 3.88541626053988 | 0.0002118075877291 | 1.0488367141091 | 3.70450062271154 | 9.3197738725557 | 893.78337229237 | 1.68741488635211 | 1.95392414212297e-07 | 6.70909230105579 | 6.91781679568266 | 2088.84994220519 | 1.03281930722422e-09 | lineage2 | dr_mutations_pyrazinamide | GLY | 0 | ERR2517005 | ERR2517005 | lineage2.2.1 | gb | UK | pnca_p.asp8gly | A | - | ASP | DA8 | pnca_complex.pdb |
411 | D8G | L4 | PZA | D | D8 | 8 | G | NA | Pre-MDR | DM | hydrophilic | hydrophobic | acidic | neutral | neg | non-polar | 3.22 | -3.445 | -0.851 | 1.89305 | -1.078 | -0.82 | 92 | 95 | -1.187 | 9 | 9 | 5 | 0.0259067357512953 | loop | 1.63333333333333 | 9.48 | 0.0007905706482679 | 48.6872097931617 | 48.6872048041474 | 48.6746878162623 | 37.2619168572472 | 34 | 38 | 0 | 0 | 38 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -8 | -1 | -3 | -5 | 6 | 0 | 9 | 17 | -0.872593718338399 | -0.219896640826873 | 0.0689490016681357 | -0.183802216538789 | -0.214659685863874 | 0.968421052631579 | -0.977759472817133 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.221 | -1.178 | 9:9 | 146/150 | D:H | 3.88541626053988 | 0.0002118075877291 | 1.0488367141091 | 3.70450062271154 | 9.3197738725557 | 893.78337229237 | 1.68741488635211 | 1.95392414212297e-07 | 6.70909230105579 | 6.91781679568266 | 2088.84994220519 | 1.03281930722422e-09 | lineage4 | dr_mutations_pyrazinamide | GLY | 0 | ERR1213926 | ERR1213926 | lineage4.1.2.1 | ma | Morocco | pnca_p.asp8gly | A | - | ASP | DA8 | pnca_complex.pdb |
412 | D8G | L2 | PZA | D | D8 | 8 | G | 1 | Pre-XDR | DM | hydrophilic | hydrophobic | acidic | neutral | neg | non-polar | 3.22 | -3.445 | -0.851 | 1.89305 | -1.078 | -0.82 | 92 | 95 | -1.187 | 9 | 9 | 5 | 0.0259067357512953 | loop | 1.63333333333333 | 9.48 | 0.0007905706482679 | 48.6872097931617 | 48.6872048041474 | 48.6746878162623 | 37.2619168572472 | 34 | 38 | 0 | 0 | 38 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -8 | -1 | -3 | -5 | 6 | 0 | 9 | 17 | -0.872593718338399 | -0.219896640826873 | 0.0689490016681357 | -0.183802216538789 | -0.214659685863874 | 0.968421052631579 | -0.977759472817133 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.221 | -1.178 | 9:9 | 146/150 | D:H | 3.88541626053988 | 0.0002118075877291 | 1.0488367141091 | 3.70450062271154 | 9.3197738725557 | 893.78337229237 | 1.68741488635211 | 1.95392414212297e-07 | 6.70909230105579 | 6.91781679568266 | 2088.84994220519 | 1.03281930722422e-09 | lineage2 | dr_mutations_pyrazinamide | GLY | 0 | ERS2592787 | ERR2677441 | lineage2.2.1 | de | Germany | pnca_p.asp8gly | A | - | ASP | DA8 | pnca_complex.pdb |
413 | D8G | L2 | PZA | D | D8 | 8 | G | 1 | MDR | DM | hydrophilic | hydrophobic | acidic | neutral | neg | non-polar | 3.22 | -3.445 | -0.851 | 1.89305 | -1.078 | -0.82 | 92 | 95 | -1.187 | 9 | 9 | 5 | 0.0259067357512953 | loop | 1.63333333333333 | 9.48 | 0.0007905706482679 | 48.6872097931617 | 48.6872048041474 | 48.6746878162623 | 37.2619168572472 | 34 | 38 | 0 | 0 | 38 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -8 | -1 | -3 | -5 | 6 | 0 | 9 | 17 | -0.872593718338399 | -0.219896640826873 | 0.0689490016681357 | -0.183802216538789 | -0.214659685863874 | 0.968421052631579 | -0.977759472817133 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.221 | -1.178 | 9:9 | 146/150 | D:H | 3.88541626053988 | 0.0002118075877291 | 1.0488367141091 | 3.70450062271154 | 9.3197738725557 | 893.78337229237 | 1.68741488635211 | 1.95392414212297e-07 | 6.70909230105579 | 6.91781679568266 | 2088.84994220519 | 1.03281930722422e-09 | lineage2 | dr_mutations_pyrazinamide | GLY | 0 | SAMN03648082,SRR2100909 | SRR2100909 | lineage2.2.1 | | | pnca_p.asp8gly | A | - | ASP | DA8 | pnca_complex.pdb |
414 | D8G | L2 | PZA | D | D8 | 8 | G | 1 | Pre-XDR | DM | hydrophilic | hydrophobic | acidic | neutral | neg | non-polar | 3.22 | -3.445 | -0.851 | 1.89305 | -1.078 | -0.82 | 92 | 95 | -1.187 | 9 | 9 | 5 | 0.0259067357512953 | loop | 1.63333333333333 | 9.48 | 0.0007905706482679 | 48.6872097931617 | 48.6872048041474 | 48.6746878162623 | 37.2619168572472 | 34 | 38 | 0 | 0 | 38 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -8 | -1 | -3 | -5 | 6 | 0 | 9 | 17 | -0.872593718338399 | -0.219896640826873 | 0.0689490016681357 | -0.183802216538789 | -0.214659685863874 | 0.968421052631579 | -0.977759472817133 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.221 | -1.178 | 9:9 | 146/150 | D:H | 3.88541626053988 | 0.0002118075877291 | 1.0488367141091 | 3.70450062271154 | 9.3197738725557 | 893.78337229237 | 1.68741488635211 | 1.95392414212297e-07 | 6.70909230105579 | 6.91781679568266 | 2088.84994220519 | 1.03281930722422e-09 | lineage2 | dr_mutations_pyrazinamide | GLY | 0 | ERS2592739 | ERR2677389 | lineage2.2.1 | de | Germany | pnca_p.asp8gly | A | - | ASP | DA8 | pnca_complex.pdb |
415 | D8G | L2 | PZA | D | D8 | 8 | G | 1 | MDR | DM | hydrophilic | hydrophobic | acidic | neutral | neg | non-polar | 3.22 | -3.445 | -0.851 | 1.89305 | -1.078 | -0.82 | 92 | 95 | -1.187 | 9 | 9 | 5 | 0.0259067357512953 | loop | 1.63333333333333 | 9.48 | 0.0007905706482679 | 48.6872097931617 | 48.6872048041474 | 48.6746878162623 | 37.2619168572472 | 34 | 38 | 0 | 0 | 38 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -8 | -1 | -3 | -5 | 6 | 0 | 9 | 17 | -0.872593718338399 | -0.219896640826873 | 0.0689490016681357 | -0.183802216538789 | -0.214659685863874 | 0.968421052631579 | -0.977759472817133 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.221 | -1.178 | 9:9 | 146/150 | D:H | 3.88541626053988 | 0.0002118075877291 | 1.0488367141091 | 3.70450062271154 | 9.3197738725557 | 893.78337229237 | 1.68741488635211 | 1.95392414212297e-07 | 6.70909230105579 | 6.91781679568266 | 2088.84994220519 | 1.03281930722422e-09 | lineage2 | dr_mutations_pyrazinamide | GLY | 0 | ERR2516875 | ERR2516875 | lineage2.2.1 | gb | UK | pnca_p.asp8gly | A | - | ASP | DA8 | pnca_complex.pdb |
416 | D8G | L4 | PZA | D | D8 | 8 | G | NA | MDR | DM | hydrophilic | hydrophobic | acidic | neutral | neg | non-polar | 3.22 | -3.445 | -0.851 | 1.89305 | -1.078 | -0.82 | 92 | 95 | -1.187 | 9 | 9 | 5 | 0.0259067357512953 | loop | 1.63333333333333 | 9.48 | 0.0007905706482679 | 48.6872097931617 | 48.6872048041474 | 48.6746878162623 | 37.2619168572472 | 34 | 38 | 0 | 0 | 38 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -8 | -1 | -3 | -5 | 6 | 0 | 9 | 17 | -0.872593718338399 | -0.219896640826873 | 0.0689490016681357 | -0.183802216538789 | -0.214659685863874 | 0.968421052631579 | -0.977759472817133 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.221 | -1.178 | 9:9 | 146/150 | D:H | 3.88541626053988 | 0.0002118075877291 | 1.0488367141091 | 3.70450062271154 | 9.3197738725557 | 893.78337229237 | 1.68741488635211 | 1.95392414212297e-07 | 6.70909230105579 | 6.91781679568266 | 2088.84994220519 | 1.03281930722422e-09 | lineage4 | dr_mutations_pyrazinamide | GLY | 0 | ERR2706989 | ERR2706989 | lineage4.3.4.2 | cd | Democratic Republic of Congo | pnca_p.asp8gly | A | - | ASP | DA8 | pnca_complex.pdb |
417 | D8G | L2 | PZA | D | D8 | 8 | G | NA | MDR | DM | hydrophilic | hydrophobic | acidic | neutral | neg | non-polar | 3.22 | -3.445 | -0.851 | 1.89305 | -1.078 | -0.82 | 92 | 95 | -1.187 | 9 | 9 | 5 | 0.0259067357512953 | loop | 1.63333333333333 | 9.48 | 0.0007905706482679 | 48.6872097931617 | 48.6872048041474 | 48.6746878162623 | 37.2619168572472 | 34 | 38 | 0 | 0 | 38 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -8 | -1 | -3 | -5 | 6 | 0 | 9 | 17 | -0.872593718338399 | -0.219896640826873 | 0.0689490016681357 | -0.183802216538789 | -0.214659685863874 | 0.968421052631579 | -0.977759472817133 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.221 | -1.178 | 9:9 | 146/150 | D:H | 3.88541626053988 | 0.0002118075877291 | 1.0488367141091 | 3.70450062271154 | 9.3197738725557 | 893.78337229237 | 1.68741488635211 | 1.95392414212297e-07 | 6.70909230105579 | 6.91781679568266 | 2088.84994220519 | 1.03281930722422e-09 | lineage2 | dr_mutations_pyrazinamide | GLY | 0 | SAMN02414980 | SRR1165480_SRR1165595_SRR1163032_SRR1162843 | lineage2.2.1 | se | Sweden | pnca_p.asp8gly | A | - | ASP | DA8 | pnca_complex.pdb |
418 | D8G | L2 | PZA | D | D8 | 8 | G | 1 | MDR | DM | hydrophilic | hydrophobic | acidic | neutral | neg | non-polar | 3.22 | -3.445 | -0.851 | 1.89305 | -1.078 | -0.82 | 92 | 95 | -1.187 | 9 | 9 | 5 | 0.0259067357512953 | loop | 1.63333333333333 | 9.48 | 0.0007905706482679 | 48.6872097931617 | 48.6872048041474 | 48.6746878162623 | 37.2619168572472 | 34 | 38 | 0 | 0 | 38 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -8 | -1 | -3 | -5 | 6 | 0 | 9 | 17 | -0.872593718338399 | -0.219896640826873 | 0.0689490016681357 | -0.183802216538789 | -0.214659685863874 | 0.968421052631579 | -0.977759472817133 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.221 | -1.178 | 9:9 | 146/150 | D:H | 3.88541626053988 | 0.0002118075877291 | 1.0488367141091 | 3.70450062271154 | 9.3197738725557 | 893.78337229237 | 1.68741488635211 | 1.95392414212297e-07 | 6.70909230105579 | 6.91781679568266 | 2088.84994220519 | 1.03281930722422e-09 | lineage2 | dr_mutations_pyrazinamide | GLY | 0 | ERR2517015 | ERR2517015 | lineage2.2.1 | gb | UK | pnca_p.asp8gly | A | - | ASP | DA8 | pnca_complex.pdb |
419 | D8G | L2 | PZA | D | D8 | 8 | G | 1 | Pre-XDR | DM | hydrophilic | hydrophobic | acidic | neutral | neg | non-polar | 3.22 | -3.445 | -0.851 | 1.89305 | -1.078 | -0.82 | 92 | 95 | -1.187 | 9 | 9 | 5 | 0.0259067357512953 | loop | 1.63333333333333 | 9.48 | 0.0007905706482679 | 48.6872097931617 | 48.6872048041474 | 48.6746878162623 | 37.2619168572472 | 34 | 38 | 0 | 0 | 38 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -8 | -1 | -3 | -5 | 6 | 0 | 9 | 17 | -0.872593718338399 | -0.219896640826873 | 0.0689490016681357 | -0.183802216538789 | -0.214659685863874 | 0.968421052631579 | -0.977759472817133 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.221 | -1.178 | 9:9 | 146/150 | D:H | 3.88541626053988 | 0.0002118075877291 | 1.0488367141091 | 3.70450062271154 | 9.3197738725557 | 893.78337229237 | 1.68741488635211 | 1.95392414212297e-07 | 6.70909230105579 | 6.91781679568266 | 2088.84994220519 | 1.03281930722422e-09 | lineage2 | dr_mutations_pyrazinamide | GLY | 0 | ERR2516213 | ERR2516213 | lineage2.2.1 | be | Belgium | pnca_p.asp8gly | A | - | ASP | DA8 | pnca_complex.pdb |
420 | D8G | L2 | PZA | D | D8 | 8 | G | NA | MDR | DM | hydrophilic | hydrophobic | acidic | neutral | neg | non-polar | 3.22 | -3.445 | -0.851 | 1.89305 | -1.078 | -0.82 | 92 | 95 | -1.187 | 9 | 9 | 5 | 0.0259067357512953 | loop | 1.63333333333333 | 9.48 | 0.0007905706482679 | 48.6872097931617 | 48.6872048041474 | 48.6746878162623 | 37.2619168572472 | 34 | 38 | 0 | 0 | 38 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -8 | -1 | -3 | -5 | 6 | 0 | 9 | 17 | -0.872593718338399 | -0.219896640826873 | 0.0689490016681357 | -0.183802216538789 | -0.214659685863874 | 0.968421052631579 | -0.977759472817133 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.221 | -1.178 | 9:9 | 146/150 | D:H | 3.88541626053988 | 0.0002118075877291 | 1.0488367141091 | 3.70450062271154 | 9.3197738725557 | 893.78337229237 | 1.68741488635211 | 1.95392414212297e-07 | 6.70909230105579 | 6.91781679568266 | 2088.84994220519 | 1.03281930722422e-09 | lineage2 | dr_mutations_pyrazinamide | GLY | 0 | SRR8380894 | SRR8380894 | lineage2.2.1 | in | India | pnca_p.asp8gly | A | - | ASP | DA8 | pnca_complex.pdb |
421 | D8G | L2 | PZA | D | D8 | 8 | G | 1 | MDR | DM | hydrophilic | hydrophobic | acidic | neutral | neg | non-polar | 3.22 | -3.445 | -0.851 | 1.89305 | -1.078 | -0.82 | 92 | 95 | -1.187 | 9 | 9 | 5 | 0.0259067357512953 | loop | 1.63333333333333 | 9.48 | 0.0007905706482679 | 48.6872097931617 | 48.6872048041474 | 48.6746878162623 | 37.2619168572472 | 34 | 38 | 0 | 0 | 38 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -8 | -1 | -3 | -5 | 6 | 0 | 9 | 17 | -0.872593718338399 | -0.219896640826873 | 0.0689490016681357 | -0.183802216538789 | -0.214659685863874 | 0.968421052631579 | -0.977759472817133 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.221 | -1.178 | 9:9 | 146/150 | D:H | 3.88541626053988 | 0.0002118075877291 | 1.0488367141091 | 3.70450062271154 | 9.3197738725557 | 893.78337229237 | 1.68741488635211 | 1.95392414212297e-07 | 6.70909230105579 | 6.91781679568266 | 2088.84994220519 | 1.03281930722422e-09 | lineage2 | dr_mutations_pyrazinamide | GLY | 0 | ERR2512979 | ERR2512979 | lineage2.2.1 | gb | UK | pnca_p.asp8gly | A | - | ASP | DA8 | pnca_complex.pdb |
422 | D8G | L2 | PZA | D | D8 | 8 | G | NA | Pre-MDR | DM | hydrophilic | hydrophobic | acidic | neutral | neg | non-polar | 3.22 | -3.445 | -0.851 | 1.89305 | -1.078 | -0.82 | 92 | 95 | -1.187 | 9 | 9 | 5 | 0.0259067357512953 | loop | 1.63333333333333 | 9.48 | 0.0007905706482679 | 48.6872097931617 | 48.6872048041474 | 48.6746878162623 | 37.2619168572472 | 34 | 38 | 0 | 0 | 38 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -8 | -1 | -3 | -5 | 6 | 0 | 9 | 17 | -0.872593718338399 | -0.219896640826873 | 0.0689490016681357 | -0.183802216538789 | -0.214659685863874 | 0.968421052631579 | -0.977759472817133 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.221 | -1.178 | 9:9 | 146/150 | D:H | 3.88541626053988 | 0.0002118075877291 | 1.0488367141091 | 3.70450062271154 | 9.3197738725557 | 893.78337229237 | 1.68741488635211 | 1.95392414212297e-07 | 6.70909230105579 | 6.91781679568266 | 2088.84994220519 | 1.03281930722422e-09 | lineage2 | dr_mutations_pyrazinamide | GLY | 0 | BGI_C-xz06202,SRR671728 | SRR671728 | lineage2.2.1 | cn | China | pnca_p.asp8gly | A | - | ASP | DA8 | pnca_complex.pdb |
423 | D8G | L4 | PZA | D | D8 | 8 | G | 0 | MDR | DM | hydrophilic | hydrophobic | acidic | neutral | neg | non-polar | 3.22 | -3.445 | -0.851 | 1.89305 | -1.078 | -0.82 | 92 | 95 | -1.187 | 9 | 9 | 5 | 0.0259067357512953 | loop | 1.63333333333333 | 9.48 | 0.0007905706482679 | 48.6872097931617 | 48.6872048041474 | 48.6746878162623 | 37.2619168572472 | 34 | 38 | 0 | 0 | 38 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -8 | -1 | -3 | -5 | 6 | 0 | 9 | 17 | -0.872593718338399 | -0.219896640826873 | 0.0689490016681357 | -0.183802216538789 | -0.214659685863874 | 0.968421052631579 | -0.977759472817133 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.221 | -1.178 | 9:9 | 146/150 | D:H | 3.88541626053988 | 0.0002118075877291 | 1.0488367141091 | 3.70450062271154 | 9.3197738725557 | 893.78337229237 | 1.68741488635211 | 1.95392414212297e-07 | 6.70909230105579 | 6.91781679568266 | 2088.84994220519 | 1.03281930722422e-09 | lineage4 | dr_mutations_pyrazinamide | GLY | 0 | ERR2516605 | ERR2516605 | lineage4.1.1.3 | pe | Peru | pnca_p.asp8gly | A | - | ASP | DA8 | pnca_complex.pdb |
424 | D8G | L2 | PZA | D | D8 | 8 | G | 1 | Pre-XDR | DM | hydrophilic | hydrophobic | acidic | neutral | neg | non-polar | 3.22 | -3.445 | -0.851 | 1.89305 | -1.078 | -0.82 | 92 | 95 | -1.187 | 9 | 9 | 5 | 0.0259067357512953 | loop | 1.63333333333333 | 9.48 | 0.0007905706482679 | 48.6872097931617 | 48.6872048041474 | 48.6746878162623 | 37.2619168572472 | 34 | 38 | 0 | 0 | 38 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -8 | -1 | -3 | -5 | 6 | 0 | 9 | 17 | -0.872593718338399 | -0.219896640826873 | 0.0689490016681357 | -0.183802216538789 | -0.214659685863874 | 0.968421052631579 | -0.977759472817133 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.221 | -1.178 | 9:9 | 146/150 | D:H | 3.88541626053988 | 0.0002118075877291 | 1.0488367141091 | 3.70450062271154 | 9.3197738725557 | 893.78337229237 | 1.68741488635211 | 1.95392414212297e-07 | 6.70909230105579 | 6.91781679568266 | 2088.84994220519 | 1.03281930722422e-09 | lineage2 | dr_mutations_pyrazinamide | GLY | 0 | ERR2510798 | ERR2510798 | lineage2.2.1 | it | Italy | pnca_p.asp8gly | A | - | ASP | DA8 | pnca_complex.pdb |
425 | D8G | L4 | PZA | D | D8 | 8 | G | NA | MDR | DM | hydrophilic | hydrophobic | acidic | neutral | neg | non-polar | 3.22 | -3.445 | -0.851 | 1.89305 | -1.078 | -0.82 | 92 | 95 | -1.187 | 9 | 9 | 5 | 0.0259067357512953 | loop | 1.63333333333333 | 9.48 | 0.0007905706482679 | 48.6872097931617 | 48.6872048041474 | 48.6746878162623 | 37.2619168572472 | 34 | 38 | 0 | 0 | 38 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -8 | -1 | -3 | -5 | 6 | 0 | 9 | 17 | -0.872593718338399 | -0.219896640826873 | 0.0689490016681357 | -0.183802216538789 | -0.214659685863874 | 0.968421052631579 | -0.977759472817133 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.221 | -1.178 | 9:9 | 146/150 | D:H | 3.88541626053988 | 0.0002118075877291 | 1.0488367141091 | 3.70450062271154 | 9.3197738725557 | 893.78337229237 | 1.68741488635211 | 1.95392414212297e-07 | 6.70909230105579 | 6.91781679568266 | 2088.84994220519 | 1.03281930722422e-09 | lineage4 | dr_mutations_pyrazinamide | GLY | 0 | ERR2707209 | ERR2707209 | lineage4.3.4.2 | cd | Democratic Republic of Congo | pnca_p.asp8gly | A | - | ASP | DA8 | pnca_complex.pdb |
426 | D8N | L2 | PZA | D | D8 | 8 | N | NA | MDR | DM | hydrophilic | hydrophilic | acidic | neutral | neg | polar | 3.22 | -1.655 | -1.182 | -1.26057 | -1.022 | -1.29 | 92 | 95 | -1.187 | 9 | 9 | 5 | 0.0259067357512953 | loop | 1.63333333333333 | 9.48 | 0.0005030904125341 | 29.1630847029077 | 29.1630732435187 | 29.1293325978315 | 18.6717493808583 | 0 | 34 | 0 | 0 | 34 | 0 | 0 | 0 | 0 | -4 | 0 | -2 | -2 | 0 | 0 | 0 | 0 | -7 | 0 | -5 | -4 | 0 | 0 | -4 | 2 | -0.41919959473151 | -0.305426356589147 | -0.242361378143505 | -0.174254049445865 | -0.337696335078534 | 0.968421052631579 | -0.977759472817133 | Destabilising | Destabilising | Stabilising | Destabilising | Destabilising | effect | -1.221 | -1.178 | 9:9 | 146/150 | D:H | 3.37290329402598 | 0.001789077082818 | 1.07995768762031 | 3.12318096596746 | 4.97876379054103 | 550.894323519252 | 1.46483345924118 | 0.0001485295621003 | 3.828187099348 | 3.53443753556636 | 1331.56873199938 | 1.55265977742841e-05 | lineage2 | dr_mutations_pyrazinamide | ASN | 0 | ERR2515173 | ERR2515173 | lineage2.2.1 | za | South Africa | pnca_p.asp8asn | A | - | ASP | DA8 | pnca_complex.pdb |
427 | D8N | L2 | PZA | D | D8 | 8 | N | NA | XDR | DM | hydrophilic | hydrophilic | acidic | neutral | neg | polar | 3.22 | -1.655 | -1.182 | -1.26057 | -1.022 | -1.29 | 92 | 95 | -1.187 | 9 | 9 | 5 | 0.0259067357512953 | loop | 1.63333333333333 | 9.48 | 0.0005030904125341 | 29.1630847029077 | 29.1630732435187 | 29.1293325978315 | 18.6717493808583 | 0 | 34 | 0 | 0 | 34 | 0 | 0 | 0 | 0 | -4 | 0 | -2 | -2 | 0 | 0 | 0 | 0 | -7 | 0 | -5 | -4 | 0 | 0 | -4 | 2 | -0.41919959473151 | -0.305426356589147 | -0.242361378143505 | -0.174254049445865 | -0.337696335078534 | 0.968421052631579 | -0.977759472817133 | Destabilising | Destabilising | Stabilising | Destabilising | Destabilising | effect | -1.221 | -1.178 | 9:9 | 146/150 | D:H | 3.37290329402598 | 0.001789077082818 | 1.07995768762031 | 3.12318096596746 | 4.97876379054103 | 550.894323519252 | 1.46483345924118 | 0.0001485295621003 | 3.828187099348 | 3.53443753556636 | 1331.56873199938 | 1.55265977742841e-05 | lineage2 | dr_mutations_pyrazinamide | ASN | 0 | ERR1035078 | ERR1035078 | lineage2.2.1 | za | South Africa | pnca_p.asp8asn | A | - | ASP | DA8 | pnca_complex.pdb |
428 | D8N | L2 | PZA | D | D8 | 8 | N | NA | XDR | DM | hydrophilic | hydrophilic | acidic | neutral | neg | polar | 3.22 | -1.655 | -1.182 | -1.26057 | -1.022 | -1.29 | 92 | 95 | -1.187 | 9 | 9 | 5 | 0.0259067357512953 | loop | 1.63333333333333 | 9.48 | 0.0005030904125341 | 29.1630847029077 | 29.1630732435187 | 29.1293325978315 | 18.6717493808583 | 0 | 34 | 0 | 0 | 34 | 0 | 0 | 0 | 0 | -4 | 0 | -2 | -2 | 0 | 0 | 0 | 0 | -7 | 0 | -5 | -4 | 0 | 0 | -4 | 2 | -0.41919959473151 | -0.305426356589147 | -0.242361378143505 | -0.174254049445865 | -0.337696335078534 | 0.968421052631579 | -0.977759472817133 | Destabilising | Destabilising | Stabilising | Destabilising | Destabilising | effect | -1.221 | -1.178 | 9:9 | 146/150 | D:H | 3.37290329402598 | 0.001789077082818 | 1.07995768762031 | 3.12318096596746 | 4.97876379054103 | 550.894323519252 | 1.46483345924118 | 0.0001485295621003 | 3.828187099348 | 3.53443753556636 | 1331.56873199938 | 1.55265977742841e-05 | lineage2 | dr_mutations_pyrazinamide | ASN | 0 | SAMN02419565 | SRR1181019_SRR1184035_SRR1159738_SRR1159790 | lineage2.2.1 | by | Belarus | pnca_p.asp8asn | A | - | ASP | DA8 | pnca_complex.pdb |
429 | D8N | L2 | PZA | D | D8 | 8 | N | NA | XDR | DM | hydrophilic | hydrophilic | acidic | neutral | neg | polar | 3.22 | -1.655 | -1.182 | -1.26057 | -1.022 | -1.29 | 92 | 95 | -1.187 | 9 | 9 | 5 | 0.0259067357512953 | loop | 1.63333333333333 | 9.48 | 0.0005030904125341 | 29.1630847029077 | 29.1630732435187 | 29.1293325978315 | 18.6717493808583 | 0 | 34 | 0 | 0 | 34 | 0 | 0 | 0 | 0 | -4 | 0 | -2 | -2 | 0 | 0 | 0 | 0 | -7 | 0 | -5 | -4 | 0 | 0 | -4 | 2 | -0.41919959473151 | -0.305426356589147 | -0.242361378143505 | -0.174254049445865 | -0.337696335078534 | 0.968421052631579 | -0.977759472817133 | Destabilising | Destabilising | Stabilising | Destabilising | Destabilising | effect | -1.221 | -1.178 | 9:9 | 146/150 | D:H | 3.37290329402598 | 0.001789077082818 | 1.07995768762031 | 3.12318096596746 | 4.97876379054103 | 550.894323519252 | 1.46483345924118 | 0.0001485295621003 | 3.828187099348 | 3.53443753556636 | 1331.56873199938 | 1.55265977742841e-05 | lineage2 | dr_mutations_pyrazinamide | ASN | 0 | SAMN02419602 | SRR1184123_SRR1180984_SRR1159362_SRR1159122 | lineage2.2.1 | by | Belarus | pnca_p.asp8asn | A | - | ASP | DA8 | pnca_complex.pdb |
430 | D8N | L2 | PZA | D | D8 | 8 | N | 0 | Pre-XDR | DM | hydrophilic | hydrophilic | acidic | neutral | neg | polar | 3.22 | -1.655 | -1.182 | -1.26057 | -1.022 | -1.29 | 92 | 95 | -1.187 | 9 | 9 | 5 | 0.0259067357512953 | loop | 1.63333333333333 | 9.48 | 0.0005030904125341 | 29.1630847029077 | 29.1630732435187 | 29.1293325978315 | 18.6717493808583 | 0 | 34 | 0 | 0 | 34 | 0 | 0 | 0 | 0 | -4 | 0 | -2 | -2 | 0 | 0 | 0 | 0 | -7 | 0 | -5 | -4 | 0 | 0 | -4 | 2 | -0.41919959473151 | -0.305426356589147 | -0.242361378143505 | -0.174254049445865 | -0.337696335078534 | 0.968421052631579 | -0.977759472817133 | Destabilising | Destabilising | Stabilising | Destabilising | Destabilising | effect | -1.221 | -1.178 | 9:9 | 146/150 | D:H | 3.37290329402598 | 0.001789077082818 | 1.07995768762031 | 3.12318096596746 | 4.97876379054103 | 550.894323519252 | 1.46483345924118 | 0.0001485295621003 | 3.828187099348 | 3.53443753556636 | 1331.56873199938 | 1.55265977742841e-05 | lineage2 | dr_mutations_pyrazinamide | ASN | 0 | ERR2515304 | ERR2515304 | lineage2.2.1 | za | South Africa | pnca_p.asp8asn | A | - | ASP | DA8 | pnca_complex.pdb |
431 | D8N | L2 | PZA | D | D8 | 8 | N | NA | XDR | DM | hydrophilic | hydrophilic | acidic | neutral | neg | polar | 3.22 | -1.655 | -1.182 | -1.26057 | -1.022 | -1.29 | 92 | 95 | -1.187 | 9 | 9 | 5 | 0.0259067357512953 | loop | 1.63333333333333 | 9.48 | 0.0005030904125341 | 29.1630847029077 | 29.1630732435187 | 29.1293325978315 | 18.6717493808583 | 0 | 34 | 0 | 0 | 34 | 0 | 0 | 0 | 0 | -4 | 0 | -2 | -2 | 0 | 0 | 0 | 0 | -7 | 0 | -5 | -4 | 0 | 0 | -4 | 2 | -0.41919959473151 | -0.305426356589147 | -0.242361378143505 | -0.174254049445865 | -0.337696335078534 | 0.968421052631579 | -0.977759472817133 | Destabilising | Destabilising | Stabilising | Destabilising | Destabilising | effect | -1.221 | -1.178 | 9:9 | 146/150 | D:H | 3.37290329402598 | 0.001789077082818 | 1.07995768762031 | 3.12318096596746 | 4.97876379054103 | 550.894323519252 | 1.46483345924118 | 0.0001485295621003 | 3.828187099348 | 3.53443753556636 | 1331.56873199938 | 1.55265977742841e-05 | lineage2 | dr_mutations_pyrazinamide | ASN | 0 | ERR2515589 | ERR2515589 | lineage2.2.1 | za | South Africa | pnca_p.asp8asn | A | - | ASP | DA8 | pnca_complex.pdb |
432 | D8N | L4 | PZA | D | D8 | 8 | N | NA | MDR | DM | hydrophilic | hydrophilic | acidic | neutral | neg | polar | 3.22 | -1.655 | -1.182 | -1.26057 | -1.022 | -1.29 | 92 | 95 | -1.187 | 9 | 9 | 5 | 0.0259067357512953 | loop | 1.63333333333333 | 9.48 | 0.0005030904125341 | 29.1630847029077 | 29.1630732435187 | 29.1293325978315 | 18.6717493808583 | 0 | 34 | 0 | 0 | 34 | 0 | 0 | 0 | 0 | -4 | 0 | -2 | -2 | 0 | 0 | 0 | 0 | -7 | 0 | -5 | -4 | 0 | 0 | -4 | 2 | -0.41919959473151 | -0.305426356589147 | -0.242361378143505 | -0.174254049445865 | -0.337696335078534 | 0.968421052631579 | -0.977759472817133 | Destabilising | Destabilising | Stabilising | Destabilising | Destabilising | effect | -1.221 | -1.178 | 9:9 | 146/150 | D:H | 3.37290329402598 | 0.001789077082818 | 1.07995768762031 | 3.12318096596746 | 4.97876379054103 | 550.894323519252 | 1.46483345924118 | 0.0001485295621003 | 3.828187099348 | 3.53443753556636 | 1331.56873199938 | 1.55265977742841e-05 | lineage4 | dr_mutations_pyrazinamide | ASN | 0 | SAMN02414918 | SRR1144735_SRR1163015_SRR1146421_SRR1163040 | lineage4.7 | se | Sweden | pnca_p.asp8asn | A | - | ASP | DA8 | pnca_complex.pdb |
433 | D8N | L2 | PZA | D | D8 | 8 | N | NA | MDR | DM | hydrophilic | hydrophilic | acidic | neutral | neg | polar | 3.22 | -1.655 | -1.182 | -1.26057 | -1.022 | -1.29 | 92 | 95 | -1.187 | 9 | 9 | 5 | 0.0259067357512953 | loop | 1.63333333333333 | 9.48 | 0.0005030904125341 | 29.1630847029077 | 29.1630732435187 | 29.1293325978315 | 18.6717493808583 | 0 | 34 | 0 | 0 | 34 | 0 | 0 | 0 | 0 | -4 | 0 | -2 | -2 | 0 | 0 | 0 | 0 | -7 | 0 | -5 | -4 | 0 | 0 | -4 | 2 | -0.41919959473151 | -0.305426356589147 | -0.242361378143505 | -0.174254049445865 | -0.337696335078534 | 0.968421052631579 | -0.977759472817133 | Destabilising | Destabilising | Stabilising | Destabilising | Destabilising | effect | -1.221 | -1.178 | 9:9 | 146/150 | D:H | 3.37290329402598 | 0.001789077082818 | 1.07995768762031 | 3.12318096596746 | 4.97876379054103 | 550.894323519252 | 1.46483345924118 | 0.0001485295621003 | 3.828187099348 | 3.53443753556636 | 1331.56873199938 | 1.55265977742841e-05 | lineage2 | dr_mutations_pyrazinamide | ASN | 0 | ERR2515650 | ERR2515650 | lineage2.2.1 | za | South Africa | pnca_p.asp8asn | A | - | ASP | DA8 | pnca_complex.pdb |
434 | D8N | L4 | PZA | D | D8 | 8 | N | 1 | Other | DM | hydrophilic | hydrophilic | acidic | neutral | neg | polar | 3.22 | -1.655 | -1.182 | -1.26057 | -1.022 | -1.29 | 92 | 95 | -1.187 | 9 | 9 | 5 | 0.0259067357512953 | loop | 1.63333333333333 | 9.48 | 0.0005030904125341 | 29.1630847029077 | 29.1630732435187 | 29.1293325978315 | 18.6717493808583 | 0 | 34 | 0 | 0 | 34 | 0 | 0 | 0 | 0 | -4 | 0 | -2 | -2 | 0 | 0 | 0 | 0 | -7 | 0 | -5 | -4 | 0 | 0 | -4 | 2 | -0.41919959473151 | -0.305426356589147 | -0.242361378143505 | -0.174254049445865 | -0.337696335078534 | 0.968421052631579 | -0.977759472817133 | Destabilising | Destabilising | Stabilising | Destabilising | Destabilising | effect | -1.221 | -1.178 | 9:9 | 146/150 | D:H | 3.37290329402598 | 0.001789077082818 | 1.07995768762031 | 3.12318096596746 | 4.97876379054103 | 550.894323519252 | 1.46483345924118 | 0.0001485295621003 | 3.828187099348 | 3.53443753556636 | 1331.56873199938 | 1.55265977742841e-05 | lineage4 | dr_mutations_pyrazinamide | ASN | 0 | SRR2100844,SAMN03648017 | SRR2100844 | lineage4.2.1 | | | pnca_p.asp8asn | A | - | ASP | DA8 | pnca_complex.pdb |
435 | D8N | L2 | PZA | D | D8 | 8 | N | NA | Pre-XDR | DM | hydrophilic | hydrophilic | acidic | neutral | neg | polar | 3.22 | -1.655 | -1.182 | -1.26057 | -1.022 | -1.29 | 92 | 95 | -1.187 | 9 | 9 | 5 | 0.0259067357512953 | loop | 1.63333333333333 | 9.48 | 0.0005030904125341 | 29.1630847029077 | 29.1630732435187 | 29.1293325978315 | 18.6717493808583 | 0 | 34 | 0 | 0 | 34 | 0 | 0 | 0 | 0 | -4 | 0 | -2 | -2 | 0 | 0 | 0 | 0 | -7 | 0 | -5 | -4 | 0 | 0 | -4 | 2 | -0.41919959473151 | -0.305426356589147 | -0.242361378143505 | -0.174254049445865 | -0.337696335078534 | 0.968421052631579 | -0.977759472817133 | Destabilising | Destabilising | Stabilising | Destabilising | Destabilising | effect | -1.221 | -1.178 | 9:9 | 146/150 | D:H | 3.37290329402598 | 0.001789077082818 | 1.07995768762031 | 3.12318096596746 | 4.97876379054103 | 550.894323519252 | 1.46483345924118 | 0.0001485295621003 | 3.828187099348 | 3.53443753556636 | 1331.56873199938 | 1.55265977742841e-05 | lineage2 | dr_mutations_pyrazinamide | ASN | 0 | SAMN02419547 | SRR1162485_SRR1181247_SRR1159044_SRR1181045 | lineage2.2.1 | by | Belarus | pnca_p.asp8asn | A | - | ASP | DA8 | pnca_complex.pdb |
436 | D8N | L2 | PZA | D | D8 | 8 | N | 1 | Pre-XDR | DM | hydrophilic | hydrophilic | acidic | neutral | neg | polar | 3.22 | -1.655 | -1.182 | -1.26057 | -1.022 | -1.29 | 92 | 95 | -1.187 | 9 | 9 | 5 | 0.0259067357512953 | loop | 1.63333333333333 | 9.48 | 0.0005030904125341 | 29.1630847029077 | 29.1630732435187 | 29.1293325978315 | 18.6717493808583 | 0 | 34 | 0 | 0 | 34 | 0 | 0 | 0 | 0 | -4 | 0 | -2 | -2 | 0 | 0 | 0 | 0 | -7 | 0 | -5 | -4 | 0 | 0 | -4 | 2 | -0.41919959473151 | -0.305426356589147 | -0.242361378143505 | -0.174254049445865 | -0.337696335078534 | 0.968421052631579 | -0.977759472817133 | Destabilising | Destabilising | Stabilising | Destabilising | Destabilising | effect | -1.221 | -1.178 | 9:9 | 146/150 | D:H | 3.37290329402598 | 0.001789077082818 | 1.07995768762031 | 3.12318096596746 | 4.97876379054103 | 550.894323519252 | 1.46483345924118 | 0.0001485295621003 | 3.828187099348 | 3.53443753556636 | 1331.56873199938 | 1.55265977742841e-05 | lineage2 | dr_mutations_pyrazinamide | ASN | 0 | ERR1873471 | ERR1873471 | lineage2.2.1 | za | South Africa | pnca_p.asp8asn | A | - | ASP | DA8 | pnca_complex.pdb |
437 | D8N | L2 | PZA | D | D8 | 8 | N | 1 | MDR | DM | hydrophilic | hydrophilic | acidic | neutral | neg | polar | 3.22 | -1.655 | -1.182 | -1.26057 | -1.022 | -1.29 | 92 | 95 | -1.187 | 9 | 9 | 5 | 0.0259067357512953 | loop | 1.63333333333333 | 9.48 | 0.0005030904125341 | 29.1630847029077 | 29.1630732435187 | 29.1293325978315 | 18.6717493808583 | 0 | 34 | 0 | 0 | 34 | 0 | 0 | 0 | 0 | -4 | 0 | -2 | -2 | 0 | 0 | 0 | 0 | -7 | 0 | -5 | -4 | 0 | 0 | -4 | 2 | -0.41919959473151 | -0.305426356589147 | -0.242361378143505 | -0.174254049445865 | -0.337696335078534 | 0.968421052631579 | -0.977759472817133 | Destabilising | Destabilising | Stabilising | Destabilising | Destabilising | effect | -1.221 | -1.178 | 9:9 | 146/150 | D:H | 3.37290329402598 | 0.001789077082818 | 1.07995768762031 | 3.12318096596746 | 4.97876379054103 | 550.894323519252 | 1.46483345924118 | 0.0001485295621003 | 3.828187099348 | 3.53443753556636 | 1331.56873199938 | 1.55265977742841e-05 | lineage2 | dr_mutations_pyrazinamide | ASN | 0 | ERR2515488 | ERR2515488 | lineage2.2.1 | za | South Africa | pnca_p.asp8asn | A | - | ASP | DA8 | pnca_complex.pdb |
438 | D8N | L4 | PZA | D | D8 | 8 | N | NA | MDR | DM | hydrophilic | hydrophilic | acidic | neutral | neg | polar | 3.22 | -1.655 | -1.182 | -1.26057 | -1.022 | -1.29 | 92 | 95 | -1.187 | 9 | 9 | 5 | 0.0259067357512953 | loop | 1.63333333333333 | 9.48 | 0.0005030904125341 | 29.1630847029077 | 29.1630732435187 | 29.1293325978315 | 18.6717493808583 | 0 | 34 | 0 | 0 | 34 | 0 | 0 | 0 | 0 | -4 | 0 | -2 | -2 | 0 | 0 | 0 | 0 | -7 | 0 | -5 | -4 | 0 | 0 | -4 | 2 | -0.41919959473151 | -0.305426356589147 | -0.242361378143505 | -0.174254049445865 | -0.337696335078534 | 0.968421052631579 | -0.977759472817133 | Destabilising | Destabilising | Stabilising | Destabilising | Destabilising | effect | -1.221 | -1.178 | 9:9 | 146/150 | D:H | 3.37290329402598 | 0.001789077082818 | 1.07995768762031 | 3.12318096596746 | 4.97876379054103 | 550.894323519252 | 1.46483345924118 | 0.0001485295621003 | 3.828187099348 | 3.53443753556636 | 1331.56873199938 | 1.55265977742841e-05 | lineage4 | dr_mutations_pyrazinamide | ASN | 0 | SAMN02414940 | SRR1167141_SRR1165398_SRR1166914_SRR1162835 | lineage4.7 | se | Sweden | pnca_p.asp8asn | A | - | ASP | DA8 | pnca_complex.pdb |
439 | D8N | L4 | PZA | D | D8 | 8 | N | NA | MDR | DM | hydrophilic | hydrophilic | acidic | neutral | neg | polar | 3.22 | -1.655 | -1.182 | -1.26057 | -1.022 | -1.29 | 92 | 95 | -1.187 | 9 | 9 | 5 | 0.0259067357512953 | loop | 1.63333333333333 | 9.48 | 0.0005030904125341 | 29.1630847029077 | 29.1630732435187 | 29.1293325978315 | 18.6717493808583 | 0 | 34 | 0 | 0 | 34 | 0 | 0 | 0 | 0 | -4 | 0 | -2 | -2 | 0 | 0 | 0 | 0 | -7 | 0 | -5 | -4 | 0 | 0 | -4 | 2 | -0.41919959473151 | -0.305426356589147 | -0.242361378143505 | -0.174254049445865 | -0.337696335078534 | 0.968421052631579 | -0.977759472817133 | Destabilising | Destabilising | Stabilising | Destabilising | Destabilising | effect | -1.221 | -1.178 | 9:9 | 146/150 | D:H | 3.37290329402598 | 0.001789077082818 | 1.07995768762031 | 3.12318096596746 | 4.97876379054103 | 550.894323519252 | 1.46483345924118 | 0.0001485295621003 | 3.828187099348 | 3.53443753556636 | 1331.56873199938 | 1.55265977742841e-05 | lineage4 | dr_mutations_pyrazinamide | ASN | 0 | ERR1023402 | ERR1023402 | lineage4.7 | | | pnca_p.asp8asn | A | - | ASP | DA8 | pnca_complex.pdb |
440 | D8N | L2 | PZA | D | D8 | 8 | N | NA | Pre-XDR | DM | hydrophilic | hydrophilic | acidic | neutral | neg | polar | 3.22 | -1.655 | -1.182 | -1.26057 | -1.022 | -1.29 | 92 | 95 | -1.187 | 9 | 9 | 5 | 0.0259067357512953 | loop | 1.63333333333333 | 9.48 | 0.0005030904125341 | 29.1630847029077 | 29.1630732435187 | 29.1293325978315 | 18.6717493808583 | 0 | 34 | 0 | 0 | 34 | 0 | 0 | 0 | 0 | -4 | 0 | -2 | -2 | 0 | 0 | 0 | 0 | -7 | 0 | -5 | -4 | 0 | 0 | -4 | 2 | -0.41919959473151 | -0.305426356589147 | -0.242361378143505 | -0.174254049445865 | -0.337696335078534 | 0.968421052631579 | -0.977759472817133 | Destabilising | Destabilising | Stabilising | Destabilising | Destabilising | effect | -1.221 | -1.178 | 9:9 | 146/150 | D:H | 3.37290329402598 | 0.001789077082818 | 1.07995768762031 | 3.12318096596746 | 4.97876379054103 | 550.894323519252 | 1.46483345924118 | 0.0001485295621003 | 3.828187099348 | 3.53443753556636 | 1331.56873199938 | 1.55265977742841e-05 | lineage2 | dr_mutations_pyrazinamide | ASN | 0 | ERR1035076 | ERR1035076 | lineage2.2.1 | za | South Africa | pnca_p.asp8asn | A | - | ASP | DA8 | pnca_complex.pdb |
441 | D8N | L2 | PZA | D | D8 | 8 | N | NA | MDR | DM | hydrophilic | hydrophilic | acidic | neutral | neg | polar | 3.22 | -1.655 | -1.182 | -1.26057 | -1.022 | -1.29 | 92 | 95 | -1.187 | 9 | 9 | 5 | 0.0259067357512953 | loop | 1.63333333333333 | 9.48 | 0.0005030904125341 | 29.1630847029077 | 29.1630732435187 | 29.1293325978315 | 18.6717493808583 | 0 | 34 | 0 | 0 | 34 | 0 | 0 | 0 | 0 | -4 | 0 | -2 | -2 | 0 | 0 | 0 | 0 | -7 | 0 | -5 | -4 | 0 | 0 | -4 | 2 | -0.41919959473151 | -0.305426356589147 | -0.242361378143505 | -0.174254049445865 | -0.337696335078534 | 0.968421052631579 | -0.977759472817133 | Destabilising | Destabilising | Stabilising | Destabilising | Destabilising | effect | -1.221 | -1.178 | 9:9 | 146/150 | D:H | 3.37290329402598 | 0.001789077082818 | 1.07995768762031 | 3.12318096596746 | 4.97876379054103 | 550.894323519252 | 1.46483345924118 | 0.0001485295621003 | 3.828187099348 | 3.53443753556636 | 1331.56873199938 | 1.55265977742841e-05 | lineage2 | dr_mutations_pyrazinamide | ASN | 0 | ERR1633956 | ERR1633956 | lineage2.2.1 | za | South Africa | pnca_p.asp8asn | A | - | ASP | DA8 | pnca_complex.pdb |
442 | D8N | L2 | PZA | D | D8 | 8 | N | 1 | XDR | DM | hydrophilic | hydrophilic | acidic | neutral | neg | polar | 3.22 | -1.655 | -1.182 | -1.26057 | -1.022 | -1.29 | 92 | 95 | -1.187 | 9 | 9 | 5 | 0.0259067357512953 | loop | 1.63333333333333 | 9.48 | 0.0005030904125341 | 29.1630847029077 | 29.1630732435187 | 29.1293325978315 | 18.6717493808583 | 0 | 34 | 0 | 0 | 34 | 0 | 0 | 0 | 0 | -4 | 0 | -2 | -2 | 0 | 0 | 0 | 0 | -7 | 0 | -5 | -4 | 0 | 0 | -4 | 2 | -0.41919959473151 | -0.305426356589147 | -0.242361378143505 | -0.174254049445865 | -0.337696335078534 | 0.968421052631579 | -0.977759472817133 | Destabilising | Destabilising | Stabilising | Destabilising | Destabilising | effect | -1.221 | -1.178 | 9:9 | 146/150 | D:H | 3.37290329402598 | 0.001789077082818 | 1.07995768762031 | 3.12318096596746 | 4.97876379054103 | 550.894323519252 | 1.46483345924118 | 0.0001485295621003 | 3.828187099348 | 3.53443753556636 | 1331.56873199938 | 1.55265977742841e-05 | lineage2 | dr_mutations_pyrazinamide | ASN | 0 | ERR1873477 | ERR1873477 | lineage2.2.1 | za | South Africa | pnca_p.asp8asn | A | - | ASP | DA8 | pnca_complex.pdb |
443 | D8N | L2 | PZA | D | D8 | 8 | N | NA | XDR | DM | hydrophilic | hydrophilic | acidic | neutral | neg | polar | 3.22 | -1.655 | -1.182 | -1.26057 | -1.022 | -1.29 | 92 | 95 | -1.187 | 9 | 9 | 5 | 0.0259067357512953 | loop | 1.63333333333333 | 9.48 | 0.0005030904125341 | 29.1630847029077 | 29.1630732435187 | 29.1293325978315 | 18.6717493808583 | 0 | 34 | 0 | 0 | 34 | 0 | 0 | 0 | 0 | -4 | 0 | -2 | -2 | 0 | 0 | 0 | 0 | -7 | 0 | -5 | -4 | 0 | 0 | -4 | 2 | -0.41919959473151 | -0.305426356589147 | -0.242361378143505 | -0.174254049445865 | -0.337696335078534 | 0.968421052631579 | -0.977759472817133 | Destabilising | Destabilising | Stabilising | Destabilising | Destabilising | effect | -1.221 | -1.178 | 9:9 | 146/150 | D:H | 3.37290329402598 | 0.001789077082818 | 1.07995768762031 | 3.12318096596746 | 4.97876379054103 | 550.894323519252 | 1.46483345924118 | 0.0001485295621003 | 3.828187099348 | 3.53443753556636 | 1331.56873199938 | 1.55265977742841e-05 | lineage2 | dr_mutations_pyrazinamide | ASN | 0 | SAMN02419587 | SRR1162498_SRR1181007_SRR1183663_SRR1158950 | lineage2.2.1 | by | Belarus | pnca_p.asp8asn | A | - | ASP | DA8 | pnca_complex.pdb |
444 | D8N | L2 | PZA | D | D8 | 8 | N | NA | MDR | DM | hydrophilic | hydrophilic | acidic | neutral | neg | polar | 3.22 | -1.655 | -1.182 | -1.26057 | -1.022 | -1.29 | 92 | 95 | -1.187 | 9 | 9 | 5 | 0.0259067357512953 | loop | 1.63333333333333 | 9.48 | 0.0005030904125341 | 29.1630847029077 | 29.1630732435187 | 29.1293325978315 | 18.6717493808583 | 0 | 34 | 0 | 0 | 34 | 0 | 0 | 0 | 0 | -4 | 0 | -2 | -2 | 0 | 0 | 0 | 0 | -7 | 0 | -5 | -4 | 0 | 0 | -4 | 2 | -0.41919959473151 | -0.305426356589147 | -0.242361378143505 | -0.174254049445865 | -0.337696335078534 | 0.968421052631579 | -0.977759472817133 | Destabilising | Destabilising | Stabilising | Destabilising | Destabilising | effect | -1.221 | -1.178 | 9:9 | 146/150 | D:H | 3.37290329402598 | 0.001789077082818 | 1.07995768762031 | 3.12318096596746 | 4.97876379054103 | 550.894323519252 | 1.46483345924118 | 0.0001485295621003 | 3.828187099348 | 3.53443753556636 | 1331.56873199938 | 1.55265977742841e-05 | lineage2 | dr_mutations_pyrazinamide | ASN | 0 | ERR1023521 | ERR1023521 | lineage2.2.1 | | | pnca_p.asp8asn | A | - | ASP | DA8 | pnca_complex.pdb |
445 | D8N | L4 | PZA | D | D8 | 8 | N | NA | Pre-XDR | DM | hydrophilic | hydrophilic | acidic | neutral | neg | polar | 3.22 | -1.655 | -1.182 | -1.26057 | -1.022 | -1.29 | 92 | 95 | -1.187 | 9 | 9 | 5 | 0.0259067357512953 | loop | 1.63333333333333 | 9.48 | 0.0005030904125341 | 29.1630847029077 | 29.1630732435187 | 29.1293325978315 | 18.6717493808583 | 0 | 34 | 0 | 0 | 34 | 0 | 0 | 0 | 0 | -4 | 0 | -2 | -2 | 0 | 0 | 0 | 0 | -7 | 0 | -5 | -4 | 0 | 0 | -4 | 2 | -0.41919959473151 | -0.305426356589147 | -0.242361378143505 | -0.174254049445865 | -0.337696335078534 | 0.968421052631579 | -0.977759472817133 | Destabilising | Destabilising | Stabilising | Destabilising | Destabilising | effect | -1.221 | -1.178 | 9:9 | 146/150 | D:H | 3.37290329402598 | 0.001789077082818 | 1.07995768762031 | 3.12318096596746 | 4.97876379054103 | 550.894323519252 | 1.46483345924118 | 0.0001485295621003 | 3.828187099348 | 3.53443753556636 | 1331.56873199938 | 1.55265977742841e-05 | lineage4 | dr_mutations_pyrazinamide | ASN | 0 | ERR1193843 | ERR1193843 | lineage4.3 | iq | Iraq | pnca_p.asp8asn | A | - | ASP | DA8 | pnca_complex.pdb |
446 | D8N | L2 | PZA | D | D8 | 8 | N | NA | MDR | DM | hydrophilic | hydrophilic | acidic | neutral | neg | polar | 3.22 | -1.655 | -1.182 | -1.26057 | -1.022 | -1.29 | 92 | 95 | -1.187 | 9 | 9 | 5 | 0.0259067357512953 | loop | 1.63333333333333 | 9.48 | 0.0005030904125341 | 29.1630847029077 | 29.1630732435187 | 29.1293325978315 | 18.6717493808583 | 0 | 34 | 0 | 0 | 34 | 0 | 0 | 0 | 0 | -4 | 0 | -2 | -2 | 0 | 0 | 0 | 0 | -7 | 0 | -5 | -4 | 0 | 0 | -4 | 2 | -0.41919959473151 | -0.305426356589147 | -0.242361378143505 | -0.174254049445865 | -0.337696335078534 | 0.968421052631579 | -0.977759472817133 | Destabilising | Destabilising | Stabilising | Destabilising | Destabilising | effect | -1.221 | -1.178 | 9:9 | 146/150 | D:H | 3.37290329402598 | 0.001789077082818 | 1.07995768762031 | 3.12318096596746 | 4.97876379054103 | 550.894323519252 | 1.46483345924118 | 0.0001485295621003 | 3.828187099348 | 3.53443753556636 | 1331.56873199938 | 1.55265977742841e-05 | lineage2 | dr_mutations_pyrazinamide | ASN | 0 | ERR1633964 | ERR1633964 | lineage2.2.1 | za | South Africa | pnca_p.asp8asn | A | - | ASP | DA8 | pnca_complex.pdb |
447 | D8N | L4 | PZA | D | D8 | 8 | N | NA | MDR | DM | hydrophilic | hydrophilic | acidic | neutral | neg | polar | 3.22 | -1.655 | -1.182 | -1.26057 | -1.022 | -1.29 | 92 | 95 | -1.187 | 9 | 9 | 5 | 0.0259067357512953 | loop | 1.63333333333333 | 9.48 | 0.0005030904125341 | 29.1630847029077 | 29.1630732435187 | 29.1293325978315 | 18.6717493808583 | 0 | 34 | 0 | 0 | 34 | 0 | 0 | 0 | 0 | -4 | 0 | -2 | -2 | 0 | 0 | 0 | 0 | -7 | 0 | -5 | -4 | 0 | 0 | -4 | 2 | -0.41919959473151 | -0.305426356589147 | -0.242361378143505 | -0.174254049445865 | -0.337696335078534 | 0.968421052631579 | -0.977759472817133 | Destabilising | Destabilising | Stabilising | Destabilising | Destabilising | effect | -1.221 | -1.178 | 9:9 | 146/150 | D:H | 3.37290329402598 | 0.001789077082818 | 1.07995768762031 | 3.12318096596746 | 4.97876379054103 | 550.894323519252 | 1.46483345924118 | 0.0001485295621003 | 3.828187099348 | 3.53443753556636 | 1331.56873199938 | 1.55265977742841e-05 | lineage4 | dr_mutations_pyrazinamide | ASN | 0 | SAMN02414943 | SRR1167090_SRR1162750_SRR1166808_SRR1165415 | lineage4.7 | se | Sweden | pnca_p.asp8asn | A | - | ASP | DA8 | pnca_complex.pdb |
448 | D8N | L2 | PZA | D | D8 | 8 | N | NA | XDR | DM | hydrophilic | hydrophilic | acidic | neutral | neg | polar | 3.22 | -1.655 | -1.182 | -1.26057 | -1.022 | -1.29 | 92 | 95 | -1.187 | 9 | 9 | 5 | 0.0259067357512953 | loop | 1.63333333333333 | 9.48 | 0.0005030904125341 | 29.1630847029077 | 29.1630732435187 | 29.1293325978315 | 18.6717493808583 | 0 | 34 | 0 | 0 | 34 | 0 | 0 | 0 | 0 | -4 | 0 | -2 | -2 | 0 | 0 | 0 | 0 | -7 | 0 | -5 | -4 | 0 | 0 | -4 | 2 | -0.41919959473151 | -0.305426356589147 | -0.242361378143505 | -0.174254049445865 | -0.337696335078534 | 0.968421052631579 | -0.977759472817133 | Destabilising | Destabilising | Stabilising | Destabilising | Destabilising | effect | -1.221 | -1.178 | 9:9 | 146/150 | D:H | 3.37290329402598 | 0.001789077082818 | 1.07995768762031 | 3.12318096596746 | 4.97876379054103 | 550.894323519252 | 1.46483345924118 | 0.0001485295621003 | 3.828187099348 | 3.53443753556636 | 1331.56873199938 | 1.55265977742841e-05 | lineage2 | dr_mutations_pyrazinamide | ASN | 0 | ERR2515238 | ERR2515238 | lineage2.2.1 | za | South Africa | pnca_p.asp8asn | A | - | ASP | DA8 | pnca_complex.pdb |
449 | D8N | L2 | PZA | D | D8 | 8 | N | 1 | XDR | DM | hydrophilic | hydrophilic | acidic | neutral | neg | polar | 3.22 | -1.655 | -1.182 | -1.26057 | -1.022 | -1.29 | 92 | 95 | -1.187 | 9 | 9 | 5 | 0.0259067357512953 | loop | 1.63333333333333 | 9.48 | 0.0005030904125341 | 29.1630847029077 | 29.1630732435187 | 29.1293325978315 | 18.6717493808583 | 0 | 34 | 0 | 0 | 34 | 0 | 0 | 0 | 0 | -4 | 0 | -2 | -2 | 0 | 0 | 0 | 0 | -7 | 0 | -5 | -4 | 0 | 0 | -4 | 2 | -0.41919959473151 | -0.305426356589147 | -0.242361378143505 | -0.174254049445865 | -0.337696335078534 | 0.968421052631579 | -0.977759472817133 | Destabilising | Destabilising | Stabilising | Destabilising | Destabilising | effect | -1.221 | -1.178 | 9:9 | 146/150 | D:H | 3.37290329402598 | 0.001789077082818 | 1.07995768762031 | 3.12318096596746 | 4.97876379054103 | 550.894323519252 | 1.46483345924118 | 0.0001485295621003 | 3.828187099348 | 3.53443753556636 | 1331.56873199938 | 1.55265977742841e-05 | lineage2 | dr_mutations_pyrazinamide | ASN | 0 | ERR1873532 | ERR1873532 | lineage2.2.1 | za | South Africa | pnca_p.asp8asn | A | - | ASP | DA8 | pnca_complex.pdb |
450 | D8N | L2 | PZA | D | D8 | 8 | N | 1 | XDR | DM | hydrophilic | hydrophilic | acidic | neutral | neg | polar | 3.22 | -1.655 | -1.182 | -1.26057 | -1.022 | -1.29 | 92 | 95 | -1.187 | 9 | 9 | 5 | 0.0259067357512953 | loop | 1.63333333333333 | 9.48 | 0.0005030904125341 | 29.1630847029077 | 29.1630732435187 | 29.1293325978315 | 18.6717493808583 | 0 | 34 | 0 | 0 | 34 | 0 | 0 | 0 | 0 | -4 | 0 | -2 | -2 | 0 | 0 | 0 | 0 | -7 | 0 | -5 | -4 | 0 | 0 | -4 | 2 | -0.41919959473151 | -0.305426356589147 | -0.242361378143505 | -0.174254049445865 | -0.337696335078534 | 0.968421052631579 | -0.977759472817133 | Destabilising | Destabilising | Stabilising | Destabilising | Destabilising | effect | -1.221 | -1.178 | 9:9 | 146/150 | D:H | 3.37290329402598 | 0.001789077082818 | 1.07995768762031 | 3.12318096596746 | 4.97876379054103 | 550.894323519252 | 1.46483345924118 | 0.0001485295621003 | 3.828187099348 | 3.53443753556636 | 1331.56873199938 | 1.55265977742841e-05 | lineage2 | dr_mutations_pyrazinamide | ASN | 0 | ERR2515301 | ERR2515301 | lineage2.2.1 | za | South Africa | pnca_p.asp8asn | A | - | ASP | DA8 | pnca_complex.pdb |
451 | D8N | L2 | PZA | D | D8 | 8 | N | NA | Pre-XDR | DM | hydrophilic | hydrophilic | acidic | neutral | neg | polar | 3.22 | -1.655 | -1.182 | -1.26057 | -1.022 | -1.29 | 92 | 95 | -1.187 | 9 | 9 | 5 | 0.0259067357512953 | loop | 1.63333333333333 | 9.48 | 0.0005030904125341 | 29.1630847029077 | 29.1630732435187 | 29.1293325978315 | 18.6717493808583 | 0 | 34 | 0 | 0 | 34 | 0 | 0 | 0 | 0 | -4 | 0 | -2 | -2 | 0 | 0 | 0 | 0 | -7 | 0 | -5 | -4 | 0 | 0 | -4 | 2 | -0.41919959473151 | -0.305426356589147 | -0.242361378143505 | -0.174254049445865 | -0.337696335078534 | 0.968421052631579 | -0.977759472817133 | Destabilising | Destabilising | Stabilising | Destabilising | Destabilising | effect | -1.221 | -1.178 | 9:9 | 146/150 | D:H | 3.37290329402598 | 0.001789077082818 | 1.07995768762031 | 3.12318096596746 | 4.97876379054103 | 550.894323519252 | 1.46483345924118 | 0.0001485295621003 | 3.828187099348 | 3.53443753556636 | 1331.56873199938 | 1.55265977742841e-05 | lineage2 | dr_mutations_pyrazinamide | ASN | 0 | ERR2515250 | ERR2515250 | lineage2.2.1 | za | South Africa | pnca_p.asp8asn | A | - | ASP | DA8 | pnca_complex.pdb |
452 | V9A | L2 | PZA | V | V9 | 9 | A | NA | MDR | DM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 6.555 | -1.286 | -2.467 | 2.03689 | -2.068 | -2.01 | 61 | 80 | -0.711 | 8 | 8 | 0 | 0 | loop | -0.933333333333333 | 9.57 | 0.0002156101768003 | 0.807902480033628 | 4.59660271789382e-05 | 0 | 0.000393645565148 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 2 | 6 | 0 | 6 | 5 | -0.325734549138804 | -0.637467700258398 | 0.0741879675696938 | -0.352600170502984 | -0.526178010471204 | 0.642105263157895 | -0.585667215815486 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.827 | -0.615 | 8:7 | 146/150 | I:C:L:V:M | -9.98760797391819 | 0.930014323968985 | 113.719344729607 | -0.0878268160765962 | NA | 127.948735098955 | -0.0926410587047397 | 1 | 0 | 0 | 11.7369754738005 | 0.984170607395186 | lineage2 | dr_mutations_pyrazinamide | ALA | 0 | SRS797047 | SRR1723549 | lineage2.2.1 | cn | China:Hebei | pnca_p.val9ala | A | - | VAL | VA9 | pnca_complex.pdb |
453 | V9A | L4 | PZA | V | V9 | 9 | A | NA | MDR | DM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 6.555 | -1.286 | -2.467 | 2.03689 | -2.068 | -2.01 | 61 | 80 | -0.711 | 8 | 8 | 0 | 0 | loop | -0.933333333333333 | 9.57 | 0.0002156101768003 | 0.807902480033628 | 4.59660271789382e-05 | 0 | 0.000393645565148 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 2 | 6 | 0 | 6 | 5 | -0.325734549138804 | -0.637467700258398 | 0.0741879675696938 | -0.352600170502984 | -0.526178010471204 | 0.642105263157895 | -0.585667215815486 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.827 | -0.615 | 8:7 | 146/150 | I:C:L:V:M | -9.98760797391819 | 0.930014323968985 | 113.719344729607 | -0.0878268160765962 | NA | 127.948735098955 | -0.0926410587047397 | 1 | 0 | 0 | 11.7369754738005 | 0.984170607395186 | lineage4 | dr_mutations_pyrazinamide | ALA | 0 | SRR671850,BGI_XZ06055 | SRR671850 | lineage4.5 | cn | China | pnca_p.val9ala | A | - | VAL | VA9 | pnca_complex.pdb |
454 | V9A | L2 | PZA | V | V9 | 9 | A | 0 | Pre-XDR | DM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 6.555 | -1.286 | -2.467 | 2.03689 | -2.068 | -2.01 | 61 | 80 | -0.711 | 8 | 8 | 0 | 0 | loop | -0.933333333333333 | 9.57 | 0.0002156101768003 | 0.807902480033628 | 4.59660271789382e-05 | 0 | 0.000393645565148 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 2 | 6 | 0 | 6 | 5 | -0.325734549138804 | -0.637467700258398 | 0.0741879675696938 | -0.352600170502984 | -0.526178010471204 | 0.642105263157895 | -0.585667215815486 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.827 | -0.615 | 8:7 | 146/150 | I:C:L:V:M | -9.98760797391819 | 0.930014323968985 | 113.719344729607 | -0.0878268160765962 | NA | 127.948735098955 | -0.0926410587047397 | 1 | 0 | 0 | 11.7369754738005 | 0.984170607395186 | lineage2 | dr_mutations_pyrazinamide | ALA | 0 | SAMN10961402 | SRR8651641 | lineage2.2.2 | cn | China:Wenzhou | pnca_p.val9ala | A | - | VAL | VA9 | pnca_complex.pdb |
455 | V9A | L2 | PZA | V | V9 | 9 | A | 0 | Pre-XDR | DM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 6.555 | -1.286 | -2.467 | 2.03689 | -2.068 | -2.01 | 61 | 80 | -0.711 | 8 | 8 | 0 | 0 | loop | -0.933333333333333 | 9.57 | 0.0002156101768003 | 0.807902480033628 | 4.59660271789382e-05 | 0 | 0.000393645565148 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 2 | 6 | 0 | 6 | 5 | -0.325734549138804 | -0.637467700258398 | 0.0741879675696938 | -0.352600170502984 | -0.526178010471204 | 0.642105263157895 | -0.585667215815486 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.827 | -0.615 | 8:7 | 146/150 | I:C:L:V:M | -9.98760797391819 | 0.930014323968985 | 113.719344729607 | -0.0878268160765962 | NA | 127.948735098955 | -0.0926410587047397 | 1 | 0 | 0 | 11.7369754738005 | 0.984170607395186 | lineage2 | dr_mutations_pyrazinamide | ALA | 0 | SAMN10961331 | SRR8651653 | lineage2.2.2 | cn | China:Wenzhou | pnca_p.val9ala | A | - | VAL | VA9 | pnca_complex.pdb |
456 | V9A | L2 | PZA | V | V9 | 9 | A | NA | MDR | DM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 6.555 | -1.286 | -2.467 | 2.03689 | -2.068 | -2.01 | 61 | 80 | -0.711 | 8 | 8 | 0 | 0 | loop | -0.933333333333333 | 9.57 | 0.0002156101768003 | 0.807902480033628 | 4.59660271789382e-05 | 0 | 0.000393645565148 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 2 | 6 | 0 | 6 | 5 | -0.325734549138804 | -0.637467700258398 | 0.0741879675696938 | -0.352600170502984 | -0.526178010471204 | 0.642105263157895 | -0.585667215815486 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.827 | -0.615 | 8:7 | 146/150 | I:C:L:V:M | -9.98760797391819 | 0.930014323968985 | 113.719344729607 | -0.0878268160765962 | NA | 127.948735098955 | -0.0926410587047397 | 1 | 0 | 0 | 11.7369754738005 | 0.984170607395186 | lineage2 | dr_mutations_pyrazinamide | ALA | 0 | SRR8380932 | SRR8380932 | lineage2.2.1 | in | India | pnca_p.val9ala | A | - | VAL | VA9 | pnca_complex.pdb |
457 | V9A | L2;L4 | PZA | V | V9 | 9 | A | 0 | MDR | DM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 6.555 | -1.286 | -2.467 | 2.03689 | -2.068 | -2.01 | 61 | 80 | -0.711 | 8 | 8 | 0 | 0 | loop | -0.933333333333333 | 9.57 | 0.0002156101768003 | 0.807902480033628 | 4.59660271789382e-05 | 0 | 0.000393645565148 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 2 | 6 | 0 | 6 | 5 | -0.325734549138804 | -0.637467700258398 | 0.0741879675696938 | -0.352600170502984 | -0.526178010471204 | 0.642105263157895 | -0.585667215815486 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.827 | -0.615 | 8:7 | 146/150 | I:C:L:V:M | -9.98760797391819 | 0.930014323968985 | 113.719344729607 | -0.0878268160765962 | NA | 127.948735098955 | -0.0926410587047397 | 1 | 0 | 0 | 11.7369754738005 | 0.984170607395186 | lineage2;lineage4 | dr_mutations_pyrazinamide | ALA | 0 | MDR_3208 | SRR6824304 | lineage4;lineage2.2.1 | cn | China: Jize County, Handan City, Hebei Province | pnca_p.val9ala | A | - | VAL | VA9 | pnca_complex.pdb |
458 | V9A | L2 | PZA | V | V9 | 9 | A | NA | XDR | DM | hydrophobic | hydrophobic | non-polar | non-polar | non-polar | non-polar | 6.555 | -1.286 | -2.467 | 2.03689 | -2.068 | -2.01 | 61 | 80 | -0.711 | 8 | 8 | 0 | 0 | loop | -0.933333333333333 | 9.57 | 0.0002156101768003 | 0.807902480033628 | 4.59660271789382e-05 | 0 | 0.000393645565148 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 2 | 6 | 0 | 6 | 5 | -0.325734549138804 | -0.637467700258398 | 0.0741879675696938 | -0.352600170502984 | -0.526178010471204 | 0.642105263157895 | -0.585667215815486 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.827 | -0.615 | 8:7 | 146/150 | I:C:L:V:M | -9.98760797391819 | 0.930014323968985 | 113.719344729607 | -0.0878268160765962 | NA | 127.948735098955 | -0.0926410587047397 | 1 | 0 | 0 | 11.7369754738005 | 0.984170607395186 | lineage2 | dr_mutations_pyrazinamide | ALA | 0 | SRS935963,SAMN03653228 | SRR2024922 | lineage2.2.1 | cn | China | pnca_p.val9ala | A | - | VAL | VA9 | pnca_complex.pdb |
459 | V9G | L3 | PZA | V | V9 | 9 | G | 1 | Pre-XDR | DM | hydrophobic | hydrophobic | non-polar | neutral | non-polar | non-polar | 6.555 | -1.063 | -3.236 | 3.70952 | -3.636 | -3.48 | 83 | 91 | -0.711 | 8 | 8 | 0 | 0 | loop | -0.933333333333333 | 9.57 | 0.0003593502946672 | 19.4256842105263 | 19.4256680571767 | 19.4169790983636 | 9.87561363723508 | 8 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | -2 | 4 | 0 | 3 | 21 | -0.269250253292806 | -0.836175710594315 | 0.135108793041907 | -0.619948849104859 | -0.910994764397906 | 0.873684210526316 | -0.585667215815486 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.827 | -0.615 | 8:7 | 146/150 | I:C:L:V:M | 2.96659528728018 | 0.0079500503166053 | 1.11770528264822 | 2.65418382943607 | 2.87215213651501 | 380.097158975938 | 1.28837632444196 | 0.0036816889015929 | 2.43395291165754 | 1.92061868691892 | 951.403114304703 | 0.0016748373055023 | lineage3 | dr_mutations_pyrazinamide | GLY | 0 | ERR2510586 | ERR2510586 | lineage3 | pk | Pakistan | pnca_p.val9gly | A | - | VAL | VA9 | pnca_complex.pdb |
460 | V9G | L3 | PZA | V | V9 | 9 | G | 1 | Pre-MDR | DM | hydrophobic | hydrophobic | non-polar | neutral | non-polar | non-polar | 6.555 | -1.063 | -3.236 | 3.70952 | -3.636 | -3.48 | 83 | 91 | -0.711 | 8 | 8 | 0 | 0 | loop | -0.933333333333333 | 9.57 | 0.0003593502946672 | 19.4256842105263 | 19.4256680571767 | 19.4169790983636 | 9.87561363723508 | 8 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | -2 | 4 | 0 | 3 | 21 | -0.269250253292806 | -0.836175710594315 | 0.135108793041907 | -0.619948849104859 | -0.910994764397906 | 0.873684210526316 | -0.585667215815486 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.827 | -0.615 | 8:7 | 146/150 | I:C:L:V:M | 2.96659528728018 | 0.0079500503166053 | 1.11770528264822 | 2.65418382943607 | 2.87215213651501 | 380.097158975938 | 1.28837632444196 | 0.0036816889015929 | 2.43395291165754 | 1.92061868691892 | 951.403114304703 | 0.0016748373055023 | lineage3 | dr_mutations_pyrazinamide | GLY | 0 | ERR2515261 | ERR2515261 | lineage3 | za | South Africa | pnca_p.val9gly | A | - | VAL | VA9 | pnca_complex.pdb |
461 | V9G | L3 | PZA | V | V9 | 9 | G | 0 | Pre-XDR | DM | hydrophobic | hydrophobic | non-polar | neutral | non-polar | non-polar | 6.555 | -1.063 | -3.236 | 3.70952 | -3.636 | -3.48 | 83 | 91 | -0.711 | 8 | 8 | 0 | 0 | loop | -0.933333333333333 | 9.57 | 0.0003593502946672 | 19.4256842105263 | 19.4256680571767 | 19.4169790983636 | 9.87561363723508 | 8 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | -2 | 4 | 0 | 3 | 21 | -0.269250253292806 | -0.836175710594315 | 0.135108793041907 | -0.619948849104859 | -0.910994764397906 | 0.873684210526316 | -0.585667215815486 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.827 | -0.615 | 8:7 | 146/150 | I:C:L:V:M | 2.96659528728018 | 0.0079500503166053 | 1.11770528264822 | 2.65418382943607 | 2.87215213651501 | 380.097158975938 | 1.28837632444196 | 0.0036816889015929 | 2.43395291165754 | 1.92061868691892 | 951.403114304703 | 0.0016748373055023 | lineage3 | dr_mutations_pyrazinamide | GLY | 0 | ERR2510469 | ERR2510469 | lineage3 | pk | Pakistan | pnca_p.val9gly | A | - | VAL | VA9 | pnca_complex.pdb |
462 | V9G | L4 | PZA | V | V9 | 9 | G | 1 | MDR | DM | hydrophobic | hydrophobic | non-polar | neutral | non-polar | non-polar | 6.555 | -1.063 | -3.236 | 3.70952 | -3.636 | -3.48 | 83 | 91 | -0.711 | 8 | 8 | 0 | 0 | loop | -0.933333333333333 | 9.57 | 0.0003593502946672 | 19.4256842105263 | 19.4256680571767 | 19.4169790983636 | 9.87561363723508 | 8 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | -2 | 4 | 0 | 3 | 21 | -0.269250253292806 | -0.836175710594315 | 0.135108793041907 | -0.619948849104859 | -0.910994764397906 | 0.873684210526316 | -0.585667215815486 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.827 | -0.615 | 8:7 | 146/150 | I:C:L:V:M | 2.96659528728018 | 0.0079500503166053 | 1.11770528264822 | 2.65418382943607 | 2.87215213651501 | 380.097158975938 | 1.28837632444196 | 0.0036816889015929 | 2.43395291165754 | 1.92061868691892 | 951.403114304703 | 0.0016748373055023 | lineage4 | dr_mutations_pyrazinamide | GLY | 0 | ERR2516547 | ERR2516547 | lineage4.1.1 | pe | Peru | pnca_p.val9gly | A | - | VAL | VA9 | pnca_complex.pdb |
463 | V9G | L3 | PZA | V | V9 | 9 | G | 1 | Pre-MDR | DM | hydrophobic | hydrophobic | non-polar | neutral | non-polar | non-polar | 6.555 | -1.063 | -3.236 | 3.70952 | -3.636 | -3.48 | 83 | 91 | -0.711 | 8 | 8 | 0 | 0 | loop | -0.933333333333333 | 9.57 | 0.0003593502946672 | 19.4256842105263 | 19.4256680571767 | 19.4169790983636 | 9.87561363723508 | 8 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | -2 | 4 | 0 | 3 | 21 | -0.269250253292806 | -0.836175710594315 | 0.135108793041907 | -0.619948849104859 | -0.910994764397906 | 0.873684210526316 | -0.585667215815486 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -0.827 | -0.615 | 8:7 | 146/150 | I:C:L:V:M | 2.96659528728018 | 0.0079500503166053 | 1.11770528264822 | 2.65418382943607 | 2.87215213651501 | 380.097158975938 | 1.28837632444196 | 0.0036816889015929 | 2.43395291165754 | 1.92061868691892 | 951.403114304703 | 0.0016748373055023 | lineage3 | dr_mutations_pyrazinamide | GLY | 0 | ERR2516050 | ERR2516050 | lineage3 | za | South Africa | pnca_p.val9gly | A | - | VAL | VA9 | pnca_complex.pdb |
464 | Q10E | L2 | PZA | Q | Q10 | 10 | E | NA | XDR | OM | hydrophilic | hydrophilic | neutral | acidic | polar | neg | 6.02 | -0.537 | -2.051 | 3.84692 | -1.976 | -0.13 | 88 | 91 | -1.214 | 9 | 9 | 0 | 0 | strand | -0.933333333333333 | 8.14 | NA | NA | NA | NA | NA | 0 | -56 | 0 | 0 | -56 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | -2 | 0 | 0 | 0 | 0 | -4 | 0 | -6 | 1 | 0 | 0 | 0 | 4 | -0.136018237082067 | -0.529974160206718 | 0.140113200125292 | -0.33691389599318 | -0.0340314136125654 | 0.926315789473684 | -1 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.229 | -1.201 | 9:9 | 147/150 | Q | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | lineage2 | other_mutations_pyrazinamide | GLU | 0 | DRR184878 | DRR184878 | lineage2.2.1 | vn | Vietnam | pnca_p.gln10glu | A | B | GLN | QA10 | pnca_complex.pdb |
465 | Q10E | L2 | PZA | Q | Q10 | 10 | E | NA | MDR | OM | hydrophilic | hydrophilic | neutral | acidic | polar | neg | 6.02 | -0.537 | -2.051 | 3.84692 | -1.976 | -0.13 | 88 | 91 | -1.214 | 9 | 9 | 0 | 0 | strand | -0.933333333333333 | 8.14 | NA | NA | NA | NA | NA | 0 | -56 | 0 | 0 | -56 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | -2 | 0 | 0 | 0 | 0 | -4 | 0 | -6 | 1 | 0 | 0 | 0 | 4 | -0.136018237082067 | -0.529974160206718 | 0.140113200125292 | -0.33691389599318 | -0.0340314136125654 | 0.926315789473684 | -1 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.229 | -1.201 | 9:9 | 147/150 | Q | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | lineage2 | other_mutations_pyrazinamide | GLU | 0 | DRR184942 | DRR184942 | lineage2.2.1 | vn | Vietnam | pnca_p.gln10glu | A | B | GLN | QA10 | pnca_complex.pdb |
466 | Q10H | L4 | PZA | Q | Q10 | 10 | H | 1 | MDR | DM | hydrophilic | hydrophobic | neutral | basic | polar | pos | 6.02 | -0.636 | -1.024 | 3.94633 | -1.814 | -0.97 | 91 | 95 | -1.214 | 9 | 9 | 0 | 0 | strand | -0.933333333333333 | 8.14 | 0.0007905706482679 | 107.166385135135 | 3795803.48336072 | Inf | 47.6847963834956 | 4 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | -11 | 0 | -8 | -3 | 0 | 0 | 2 | 2 | -0.161094224924012 | -0.264599483204134 | 0.143733928714516 | -0.309292412617221 | -0.253926701570681 | 0.957894736842105 | -1 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.229 | -1.201 | 9:9 | 147/150 | Q | 15.1494066679727 | 0.925233417916174 | 161.432542878774 | 0.0938435732834176 | 24.1993753469043 | NA | 2.03005858162844 | 3.58120158191569e-09 | 8.44597123233921 | 12.2081619622864 | Inf | 5.00558510128865e-12 | lineage4 | dr_mutations_pyrazinamide | HIS | 0 | 436 | ERR3014581 | lineage4.1.2.1 | tn | Tunisia:Bizerte | pnca_p.gln10his | A | B | GLN | QA10 | pnca_complex.pdb |
467 | Q10H | L4 | PZA | Q | Q10 | 10 | H | 1 | MDR | DM | hydrophilic | hydrophobic | neutral | basic | polar | pos | 6.02 | -0.636 | -1.024 | 3.94633 | -1.814 | -0.97 | 91 | 95 | -1.214 | 9 | 9 | 0 | 0 | strand | -0.933333333333333 | 8.14 | 0.0007905706482679 | 107.166385135135 | 3795803.48336072 | Inf | 47.6847963834956 | 4 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | -11 | 0 | -8 | -3 | 0 | 0 | 2 | 2 | -0.161094224924012 | -0.264599483204134 | 0.143733928714516 | -0.309292412617221 | -0.253926701570681 | 0.957894736842105 | -1 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.229 | -1.201 | 9:9 | 147/150 | Q | 15.1494066679727 | 0.925233417916174 | 161.432542878774 | 0.0938435732834176 | 24.1993753469043 | NA | 2.03005858162844 | 3.58120158191569e-09 | 8.44597123233921 | 12.2081619622864 | Inf | 5.00558510128865e-12 | lineage4 | dr_mutations_pyrazinamide | HIS | 0 | 3553 | ERR3013479 | lineage4.1.2.1 | tn | Tunisia:Bizerte | pnca_p.gln10his | A | B | GLN | QA10 | pnca_complex.pdb |
468 | Q10H | L4 | PZA | Q | Q10 | 10 | H | 1 | XDR | DM | hydrophilic | hydrophobic | neutral | basic | polar | pos | 6.02 | -0.636 | -1.024 | 3.94633 | -1.814 | -0.97 | 91 | 95 | -1.214 | 9 | 9 | 0 | 0 | strand | -0.933333333333333 | 8.14 | 0.0007905706482679 | 107.166385135135 | 3795803.48336072 | Inf | 47.6847963834956 | 4 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | -11 | 0 | -8 | -3 | 0 | 0 | 2 | 2 | -0.161094224924012 | -0.264599483204134 | 0.143733928714516 | -0.309292412617221 | -0.253926701570681 | 0.957894736842105 | -1 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.229 | -1.201 | 9:9 | 147/150 | Q | 15.1494066679727 | 0.925233417916174 | 161.432542878774 | 0.0938435732834176 | 24.1993753469043 | NA | 2.03005858162844 | 3.58120158191569e-09 | 8.44597123233921 | 12.2081619622864 | Inf | 5.00558510128865e-12 | lineage4 | dr_mutations_pyrazinamide | HIS | 0 | 8626 | ERR3014594 | lineage4.1.2.1 | tn | Tunisia:Bizerte | pnca_p.gln10his | A | B | GLN | QA10 | pnca_complex.pdb |
469 | Q10H | L4 | PZA | Q | Q10 | 10 | H | 1 | MDR | DM | hydrophilic | hydrophobic | neutral | basic | polar | pos | 6.02 | -0.636 | -1.024 | 3.94633 | -1.814 | -0.97 | 91 | 95 | -1.214 | 9 | 9 | 0 | 0 | strand | -0.933333333333333 | 8.14 | 0.0007905706482679 | 107.166385135135 | 3795803.48336072 | Inf | 47.6847963834956 | 4 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | -11 | 0 | -8 | -3 | 0 | 0 | 2 | 2 | -0.161094224924012 | -0.264599483204134 | 0.143733928714516 | -0.309292412617221 | -0.253926701570681 | 0.957894736842105 | -1 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.229 | -1.201 | 9:9 | 147/150 | Q | 15.1494066679727 | 0.925233417916174 | 161.432542878774 | 0.0938435732834176 | 24.1993753469043 | NA | 2.03005858162844 | 3.58120158191569e-09 | 8.44597123233921 | 12.2081619622864 | Inf | 5.00558510128865e-12 | lineage4 | dr_mutations_pyrazinamide | HIS | 0 | 8649 | ERR3014595 | lineage4.1.2.1 | tn | Tunisia:Bizerte | pnca_p.gln10his | A | B | GLN | QA10 | pnca_complex.pdb |
470 | Q10H | L4 | PZA | Q | Q10 | 10 | H | 1 | MDR | DM | hydrophilic | hydrophobic | neutral | basic | polar | pos | 6.02 | -0.636 | -1.024 | 3.94633 | -1.814 | -0.97 | 91 | 95 | -1.214 | 9 | 9 | 0 | 0 | strand | -0.933333333333333 | 8.14 | 0.0007905706482679 | 107.166385135135 | 3795803.48336072 | Inf | 47.6847963834956 | 4 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | -11 | 0 | -8 | -3 | 0 | 0 | 2 | 2 | -0.161094224924012 | -0.264599483204134 | 0.143733928714516 | -0.309292412617221 | -0.253926701570681 | 0.957894736842105 | -1 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.229 | -1.201 | 9:9 | 147/150 | Q | 15.1494066679727 | 0.925233417916174 | 161.432542878774 | 0.0938435732834176 | 24.1993753469043 | NA | 2.03005858162844 | 3.58120158191569e-09 | 8.44597123233921 | 12.2081619622864 | Inf | 5.00558510128865e-12 | lineage4 | dr_mutations_pyrazinamide | HIS | 0 | 13025 | ERR3014604 | lineage4.1.2.1 | tn | Tunisia:Bizerte | pnca_p.gln10his | A | B | GLN | QA10 | pnca_complex.pdb |
471 | Q10H | L4 | PZA | Q | Q10 | 10 | H | 1 | Pre-XDR | DM | hydrophilic | hydrophobic | neutral | basic | polar | pos | 6.02 | -0.636 | -1.024 | 3.94633 | -1.814 | -0.97 | 91 | 95 | -1.214 | 9 | 9 | 0 | 0 | strand | -0.933333333333333 | 8.14 | 0.0007905706482679 | 107.166385135135 | 3795803.48336072 | Inf | 47.6847963834956 | 4 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | -11 | 0 | -8 | -3 | 0 | 0 | 2 | 2 | -0.161094224924012 | -0.264599483204134 | 0.143733928714516 | -0.309292412617221 | -0.253926701570681 | 0.957894736842105 | -1 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.229 | -1.201 | 9:9 | 147/150 | Q | 15.1494066679727 | 0.925233417916174 | 161.432542878774 | 0.0938435732834176 | 24.1993753469043 | NA | 2.03005858162844 | 3.58120158191569e-09 | 8.44597123233921 | 12.2081619622864 | Inf | 5.00558510128865e-12 | lineage4 | dr_mutations_pyrazinamide | HIS | 0 | 10942 | ERR3014599 | lineage4.1.2.1 | tn | Tunisia:Bizerte | pnca_p.gln10his | A | B | GLN | QA10 | pnca_complex.pdb |
472 | Q10H | L2 | PZA | Q | Q10 | 10 | H | 1 | Pre-XDR | DM | hydrophilic | hydrophobic | neutral | basic | polar | pos | 6.02 | -0.636 | -1.024 | 3.94633 | -1.814 | -0.97 | 91 | 95 | -1.214 | 9 | 9 | 0 | 0 | strand | -0.933333333333333 | 8.14 | 0.0007905706482679 | 107.166385135135 | 3795803.48336072 | Inf | 47.6847963834956 | 4 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | -11 | 0 | -8 | -3 | 0 | 0 | 2 | 2 | -0.161094224924012 | -0.264599483204134 | 0.143733928714516 | -0.309292412617221 | -0.253926701570681 | 0.957894736842105 | -1 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.229 | -1.201 | 9:9 | 147/150 | Q | 15.1494066679727 | 0.925233417916174 | 161.432542878774 | 0.0938435732834176 | 24.1993753469043 | NA | 2.03005858162844 | 3.58120158191569e-09 | 8.44597123233921 | 12.2081619622864 | Inf | 5.00558510128865e-12 | lineage2 | dr_mutations_pyrazinamide | HIS | 0 | MDR_19329 | SRR6824407 | lineage2.2.1 | cn | China: Luoding City, Yunfu City, Guangdong Province | pnca_p.gln10his | A | B | GLN | QA10 | pnca_complex.pdb |
473 | Q10H | L2 | PZA | Q | Q10 | 10 | H | 1 | XDR | DM | hydrophilic | hydrophobic | neutral | basic | polar | pos | 6.02 | -0.636 | -1.024 | 3.94633 | -1.814 | -0.97 | 91 | 95 | -1.214 | 9 | 9 | 0 | 0 | strand | -0.933333333333333 | 8.14 | 0.0007905706482679 | 107.166385135135 | 3795803.48336072 | Inf | 47.6847963834956 | 4 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | -11 | 0 | -8 | -3 | 0 | 0 | 2 | 2 | -0.161094224924012 | -0.264599483204134 | 0.143733928714516 | -0.309292412617221 | -0.253926701570681 | 0.957894736842105 | -1 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.229 | -1.201 | 9:9 | 147/150 | Q | 15.1494066679727 | 0.925233417916174 | 161.432542878774 | 0.0938435732834176 | 24.1993753469043 | NA | 2.03005858162844 | 3.58120158191569e-09 | 8.44597123233921 | 12.2081619622864 | Inf | 5.00558510128865e-12 | lineage2 | dr_mutations_pyrazinamide | HIS | 0 | ERR2516546 | ERR2516546 | lineage2.2.1 | pe | Peru | pnca_p.gln10his | A | B | GLN | QA10 | pnca_complex.pdb |
474 | Q10H | L4 | PZA | Q | Q10 | 10 | H | 1 | MDR | DM | hydrophilic | hydrophobic | neutral | basic | polar | pos | 6.02 | -0.636 | -1.024 | 3.94633 | -1.814 | -0.97 | 91 | 95 | -1.214 | 9 | 9 | 0 | 0 | strand | -0.933333333333333 | 8.14 | 0.0007905706482679 | 107.166385135135 | 3795803.48336072 | Inf | 47.6847963834956 | 4 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | -11 | 0 | -8 | -3 | 0 | 0 | 2 | 2 | -0.161094224924012 | -0.264599483204134 | 0.143733928714516 | -0.309292412617221 | -0.253926701570681 | 0.957894736842105 | -1 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.229 | -1.201 | 9:9 | 147/150 | Q | 15.1494066679727 | 0.925233417916174 | 161.432542878774 | 0.0938435732834176 | 24.1993753469043 | NA | 2.03005858162844 | 3.58120158191569e-09 | 8.44597123233921 | 12.2081619622864 | Inf | 5.00558510128865e-12 | lineage4 | dr_mutations_pyrazinamide | HIS | 0 | 2109 | ERR3014583 | lineage4.1.2.1 | tn | Tunisia:Bizerte | pnca_p.gln10his | A | B | GLN | QA10 | pnca_complex.pdb |
475 | Q10H | L4 | PZA | Q | Q10 | 10 | H | 1 | XDR | DM | hydrophilic | hydrophobic | neutral | basic | polar | pos | 6.02 | -0.636 | -1.024 | 3.94633 | -1.814 | -0.97 | 91 | 95 | -1.214 | 9 | 9 | 0 | 0 | strand | -0.933333333333333 | 8.14 | 0.0007905706482679 | 107.166385135135 | 3795803.48336072 | Inf | 47.6847963834956 | 4 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | -11 | 0 | -8 | -3 | 0 | 0 | 2 | 2 | -0.161094224924012 | -0.264599483204134 | 0.143733928714516 | -0.309292412617221 | -0.253926701570681 | 0.957894736842105 | -1 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.229 | -1.201 | 9:9 | 147/150 | Q | 15.1494066679727 | 0.925233417916174 | 161.432542878774 | 0.0938435732834176 | 24.1993753469043 | NA | 2.03005858162844 | 3.58120158191569e-09 | 8.44597123233921 | 12.2081619622864 | Inf | 5.00558510128865e-12 | lineage4 | dr_mutations_pyrazinamide | HIS | 0 | 14666 | ERR3014613 | lineage4.1.2.1 | tn | Tunisia:Bizerte | pnca_p.gln10his | A | B | GLN | QA10 | pnca_complex.pdb |
476 | Q10H | L4 | PZA | Q | Q10 | 10 | H | 1 | MDR | DM | hydrophilic | hydrophobic | neutral | basic | polar | pos | 6.02 | -0.636 | -1.024 | 3.94633 | -1.814 | -0.97 | 91 | 95 | -1.214 | 9 | 9 | 0 | 0 | strand | -0.933333333333333 | 8.14 | 0.0007905706482679 | 107.166385135135 | 3795803.48336072 | Inf | 47.6847963834956 | 4 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | -11 | 0 | -8 | -3 | 0 | 0 | 2 | 2 | -0.161094224924012 | -0.264599483204134 | 0.143733928714516 | -0.309292412617221 | -0.253926701570681 | 0.957894736842105 | -1 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.229 | -1.201 | 9:9 | 147/150 | Q | 15.1494066679727 | 0.925233417916174 | 161.432542878774 | 0.0938435732834176 | 24.1993753469043 | NA | 2.03005858162844 | 3.58120158191569e-09 | 8.44597123233921 | 12.2081619622864 | Inf | 5.00558510128865e-12 | lineage4 | dr_mutations_pyrazinamide | HIS | 0 | 5069 | ERR3014587 | lineage4.1.2.1 | tn | Tunisia:Bizerte | pnca_p.gln10his | A | B | GLN | QA10 | pnca_complex.pdb |
477 | Q10H | L2 | PZA | Q | Q10 | 10 | H | NA | Pre-XDR | DM | hydrophilic | hydrophobic | neutral | basic | polar | pos | 6.02 | -0.636 | -1.024 | 3.94633 | -1.814 | -0.97 | 91 | 95 | -1.214 | 9 | 9 | 0 | 0 | strand | -0.933333333333333 | 8.14 | 0.0007905706482679 | 107.166385135135 | 3795803.48336072 | Inf | 47.6847963834956 | 4 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | -11 | 0 | -8 | -3 | 0 | 0 | 2 | 2 | -0.161094224924012 | -0.264599483204134 | 0.143733928714516 | -0.309292412617221 | -0.253926701570681 | 0.957894736842105 | -1 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.229 | -1.201 | 9:9 | 147/150 | Q | 15.1494066679727 | 0.925233417916174 | 161.432542878774 | 0.0938435732834176 | 24.1993753469043 | NA | 2.03005858162844 | 3.58120158191569e-09 | 8.44597123233921 | 12.2081619622864 | Inf | 5.00558510128865e-12 | lineage2 | dr_mutations_pyrazinamide | HIS | 0 | SRS797051 | SRR1723552 | lineage2.2.1 | cn | China:Guangdong | pnca_p.gln10his | A | B | GLN | QA10 | pnca_complex.pdb |
478 | Q10L | L4 | PZA | Q | Q10 | 10 | L | NA | Pre-XDR | OM | hydrophilic | hydrophobic | neutral | non-polar | polar | non-polar | 6.02 | -1.694 | 0.641 | 0.169275 | -0.188 | 0.05 | 91 | 95 | -1.214 | 9 | 9 | 0 | 0 | strand | -0.933333333333333 | 8.14 | NA | NA | NA | NA | NA | 20 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4 | 0 | 4 | 0 | 0 | 0 | 0 | 0 | -3 | 0 | -3 | -3 | 2 | 0 | 6 | 4 | -0.429078014184397 | 0.545068027210884 | 0.00616536396681211 | -0.0320545609548167 | 0.0280898876404494 | 0.957894736842105 | -1 | Destabilising | Stabilising | Destabilising | Destabilising | Stabilising | effect | -1.229 | -1.201 | 9:9 | 147/150 | Q | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | lineage4 | other_mutations_pyrazinamide | LEU | 0 | SAMN02567710 | SRR1166324 | lineage4.1.2.1 | ro | Romania | pnca_p.gln10leu | A | B | GLN | QA10 | pnca_complex.pdb |
479 | Q10P | L4 | PZA | Q | Q10 | 10 | P | 1 | Pre-XDR | DM | hydrophilic | hydrophilic | neutral | non-polar | polar | non-polar | 6.02 | -1.771 | -0.631 | 6.78299 | -2.963 | -0.11 | 95 | 95 | -1.214 | 9 | 9 | 0 | 0 | strand | -0.933333333333333 | 8.14 | 0.0211297973264338 | 156.233890214797 | 156.233722233267 | 156.382472756358 | 1333.51093453962 | 38 | -2 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 6 | 2 | 4 | 0 | 0 | 0 | 0 | 0 | -8 | 2 | -6 | -4 | 0 | 0 | 2 | 0 | -0.448581560283688 | -0.163049095607235 | 0.247051260571537 | -0.505200341005968 | -0.0287958115183246 | 1 | -1 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.229 | -1.201 | 9:9 | 147/150 | Q | 5.05135310548255 | 2.49562215648785e-55 | 0.322395320006857 | 15.6681961306855 | 87.7376148601903 | 314.979076956589 | 2.19377524680641 | 1.27822918710216e-207 | 206.893391269988 | 83.6783303393677 | 330.782028899935 | 5.90060424845557e-292 | lineage4 | dr_mutations_pyrazinamide | PRO | 0 | ERR760750 | ERR760750 | lineage4.1.2.1 | ar | Argentina | pnca_p.gln10pro | A | B | GLN | QA10 | pnca_complex.pdb |
480 | Q10P | L4 | PZA | Q | Q10 | 10 | P | 1 | Pre-XDR | DM | hydrophilic | hydrophilic | neutral | non-polar | polar | non-polar | 6.02 | -1.771 | -0.631 | 6.78299 | -2.963 | -0.11 | 95 | 95 | -1.214 | 9 | 9 | 0 | 0 | strand | -0.933333333333333 | 8.14 | 0.0211297973264338 | 156.233890214797 | 156.233722233267 | 156.382472756358 | 1333.51093453962 | 38 | -2 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 6 | 2 | 4 | 0 | 0 | 0 | 0 | 0 | -8 | 2 | -6 | -4 | 0 | 0 | 2 | 0 | -0.448581560283688 | -0.163049095607235 | 0.247051260571537 | -0.505200341005968 | -0.0287958115183246 | 1 | -1 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.229 | -1.201 | 9:9 | 147/150 | Q | 5.05135310548255 | 2.49562215648785e-55 | 0.322395320006857 | 15.6681961306855 | 87.7376148601903 | 314.979076956589 | 2.19377524680641 | 1.27822918710216e-207 | 206.893391269988 | 83.6783303393677 | 330.782028899935 | 5.90060424845557e-292 | lineage4 | dr_mutations_pyrazinamide | PRO | 0 | ERR760884 | ERR760884 | lineage4.1.2.1 | ar | Argentina | pnca_p.gln10pro | A | B | GLN | QA10 | pnca_complex.pdb |
481 | Q10P | L4 | PZA | Q | Q10 | 10 | P | 1 | Pre-XDR | DM | hydrophilic | hydrophilic | neutral | non-polar | polar | non-polar | 6.02 | -1.771 | -0.631 | 6.78299 | -2.963 | -0.11 | 95 | 95 | -1.214 | 9 | 9 | 0 | 0 | strand | -0.933333333333333 | 8.14 | 0.0211297973264338 | 156.233890214797 | 156.233722233267 | 156.382472756358 | 1333.51093453962 | 38 | -2 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 6 | 2 | 4 | 0 | 0 | 0 | 0 | 0 | -8 | 2 | -6 | -4 | 0 | 0 | 2 | 0 | -0.448581560283688 | -0.163049095607235 | 0.247051260571537 | -0.505200341005968 | -0.0287958115183246 | 1 | -1 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.229 | -1.201 | 9:9 | 147/150 | Q | 5.05135310548255 | 2.49562215648785e-55 | 0.322395320006857 | 15.6681961306855 | 87.7376148601903 | 314.979076956589 | 2.19377524680641 | 1.27822918710216e-207 | 206.893391269988 | 83.6783303393677 | 330.782028899935 | 5.90060424845557e-292 | lineage4 | dr_mutations_pyrazinamide | PRO | 0 | ERR757161 | ERR757161 | lineage4.1.2.1 | ar | Argentina | pnca_p.gln10pro | A | B | GLN | QA10 | pnca_complex.pdb |
482 | Q10P | L4 | PZA | Q | Q10 | 10 | P | 1 | Pre-XDR | DM | hydrophilic | hydrophilic | neutral | non-polar | polar | non-polar | 6.02 | -1.771 | -0.631 | 6.78299 | -2.963 | -0.11 | 95 | 95 | -1.214 | 9 | 9 | 0 | 0 | strand | -0.933333333333333 | 8.14 | 0.0211297973264338 | 156.233890214797 | 156.233722233267 | 156.382472756358 | 1333.51093453962 | 38 | -2 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 6 | 2 | 4 | 0 | 0 | 0 | 0 | 0 | -8 | 2 | -6 | -4 | 0 | 0 | 2 | 0 | -0.448581560283688 | -0.163049095607235 | 0.247051260571537 | -0.505200341005968 | -0.0287958115183246 | 1 | -1 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.229 | -1.201 | 9:9 | 147/150 | Q | 5.05135310548255 | 2.49562215648785e-55 | 0.322395320006857 | 15.6681961306855 | 87.7376148601903 | 314.979076956589 | 2.19377524680641 | 1.27822918710216e-207 | 206.893391269988 | 83.6783303393677 | 330.782028899935 | 5.90060424845557e-292 | lineage4 | dr_mutations_pyrazinamide | PRO | 0 | ERR760867 | ERR760867 | lineage4.1.2.1 | ar | Argentina | pnca_p.gln10pro | A | B | GLN | QA10 | pnca_complex.pdb |
483 | Q10P | L2 | PZA | Q | Q10 | 10 | P | NA | Pre-XDR | DM | hydrophilic | hydrophilic | neutral | non-polar | polar | non-polar | 6.02 | -1.771 | -0.631 | 6.78299 | -2.963 | -0.11 | 95 | 95 | -1.214 | 9 | 9 | 0 | 0 | strand | -0.933333333333333 | 8.14 | 0.0211297973264338 | 156.233890214797 | 156.233722233267 | 156.382472756358 | 1333.51093453962 | 38 | -2 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 6 | 2 | 4 | 0 | 0 | 0 | 0 | 0 | -8 | 2 | -6 | -4 | 0 | 0 | 2 | 0 | -0.448581560283688 | -0.163049095607235 | 0.247051260571537 | -0.505200341005968 | -0.0287958115183246 | 1 | -1 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.229 | -1.201 | 9:9 | 147/150 | Q | 5.05135310548255 | 2.49562215648785e-55 | 0.322395320006857 | 15.6681961306855 | 87.7376148601903 | 314.979076956589 | 2.19377524680641 | 1.27822918710216e-207 | 206.893391269988 | 83.6783303393677 | 330.782028899935 | 5.90060424845557e-292 | lineage2 | dr_mutations_pyrazinamide | PRO | 0 | SAMN02360601 | SRR1049039_SRR1013645_SRR1013644_SRR1049038 | lineage2.2.2 | kr | South Korea | pnca_p.gln10pro | A | B | GLN | QA10 | pnca_complex.pdb |
484 | Q10P | L4 | PZA | Q | Q10 | 10 | P | 1 | Pre-XDR | DM | hydrophilic | hydrophilic | neutral | non-polar | polar | non-polar | 6.02 | -1.771 | -0.631 | 6.78299 | -2.963 | -0.11 | 95 | 95 | -1.214 | 9 | 9 | 0 | 0 | strand | -0.933333333333333 | 8.14 | 0.0211297973264338 | 156.233890214797 | 156.233722233267 | 156.382472756358 | 1333.51093453962 | 38 | -2 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 6 | 2 | 4 | 0 | 0 | 0 | 0 | 0 | -8 | 2 | -6 | -4 | 0 | 0 | 2 | 0 | -0.448581560283688 | -0.163049095607235 | 0.247051260571537 | -0.505200341005968 | -0.0287958115183246 | 1 | -1 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.229 | -1.201 | 9:9 | 147/150 | Q | 5.05135310548255 | 2.49562215648785e-55 | 0.322395320006857 | 15.6681961306855 | 87.7376148601903 | 314.979076956589 | 2.19377524680641 | 1.27822918710216e-207 | 206.893391269988 | 83.6783303393677 | 330.782028899935 | 5.90060424845557e-292 | lineage4 | dr_mutations_pyrazinamide | PRO | 0 | ERR757145 | ERR757145 | lineage4.1.2.1 | ar | Argentina | pnca_p.gln10pro | A | B | GLN | QA10 | pnca_complex.pdb |
485 | Q10P | L4 | PZA | Q | Q10 | 10 | P | 1 | MDR | DM | hydrophilic | hydrophilic | neutral | non-polar | polar | non-polar | 6.02 | -1.771 | -0.631 | 6.78299 | -2.963 | -0.11 | 95 | 95 | -1.214 | 9 | 9 | 0 | 0 | strand | -0.933333333333333 | 8.14 | 0.0211297973264338 | 156.233890214797 | 156.233722233267 | 156.382472756358 | 1333.51093453962 | 38 | -2 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 6 | 2 | 4 | 0 | 0 | 0 | 0 | 0 | -8 | 2 | -6 | -4 | 0 | 0 | 2 | 0 | -0.448581560283688 | -0.163049095607235 | 0.247051260571537 | -0.505200341005968 | -0.0287958115183246 | 1 | -1 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.229 | -1.201 | 9:9 | 147/150 | Q | 5.05135310548255 | 2.49562215648785e-55 | 0.322395320006857 | 15.6681961306855 | 87.7376148601903 | 314.979076956589 | 2.19377524680641 | 1.27822918710216e-207 | 206.893391269988 | 83.6783303393677 | 330.782028899935 | 5.90060424845557e-292 | lineage4 | dr_mutations_pyrazinamide | PRO | 0 | ERS457454 | ERR551592_ERR551591 | lineage4.8 | uz | Nukus | pnca_p.gln10pro | A | B | GLN | QA10 | pnca_complex.pdb |
486 | Q10P | L4 | PZA | Q | Q10 | 10 | P | 1 | Pre-XDR | DM | hydrophilic | hydrophilic | neutral | non-polar | polar | non-polar | 6.02 | -1.771 | -0.631 | 6.78299 | -2.963 | -0.11 | 95 | 95 | -1.214 | 9 | 9 | 0 | 0 | strand | -0.933333333333333 | 8.14 | 0.0211297973264338 | 156.233890214797 | 156.233722233267 | 156.382472756358 | 1333.51093453962 | 38 | -2 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 6 | 2 | 4 | 0 | 0 | 0 | 0 | 0 | -8 | 2 | -6 | -4 | 0 | 0 | 2 | 0 | -0.448581560283688 | -0.163049095607235 | 0.247051260571537 | -0.505200341005968 | -0.0287958115183246 | 1 | -1 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.229 | -1.201 | 9:9 | 147/150 | Q | 5.05135310548255 | 2.49562215648785e-55 | 0.322395320006857 | 15.6681961306855 | 87.7376148601903 | 314.979076956589 | 2.19377524680641 | 1.27822918710216e-207 | 206.893391269988 | 83.6783303393677 | 330.782028899935 | 5.90060424845557e-292 | lineage4 | dr_mutations_pyrazinamide | PRO | 0 | ERR760838 | ERR760838 | lineage4.1.2.1 | ar | Argentina | pnca_p.gln10pro | A | B | GLN | QA10 | pnca_complex.pdb |
487 | Q10P | L4 | PZA | Q | Q10 | 10 | P | 1 | XDR | DM | hydrophilic | hydrophilic | neutral | non-polar | polar | non-polar | 6.02 | -1.771 | -0.631 | 6.78299 | -2.963 | -0.11 | 95 | 95 | -1.214 | 9 | 9 | 0 | 0 | strand | -0.933333333333333 | 8.14 | 0.0211297973264338 | 156.233890214797 | 156.233722233267 | 156.382472756358 | 1333.51093453962 | 38 | -2 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 6 | 2 | 4 | 0 | 0 | 0 | 0 | 0 | -8 | 2 | -6 | -4 | 0 | 0 | 2 | 0 | -0.448581560283688 | -0.163049095607235 | 0.247051260571537 | -0.505200341005968 | -0.0287958115183246 | 1 | -1 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.229 | -1.201 | 9:9 | 147/150 | Q | 5.05135310548255 | 2.49562215648785e-55 | 0.322395320006857 | 15.6681961306855 | 87.7376148601903 | 314.979076956589 | 2.19377524680641 | 1.27822918710216e-207 | 206.893391269988 | 83.6783303393677 | 330.782028899935 | 5.90060424845557e-292 | lineage4 | dr_mutations_pyrazinamide | PRO | 0 | ERR760823 | ERR760823 | lineage4.1.2.1 | ar | Argentina | pnca_p.gln10pro | A | B | GLN | QA10 | pnca_complex.pdb |
488 | Q10P | L4 | PZA | Q | Q10 | 10 | P | 1 | Pre-XDR | DM | hydrophilic | hydrophilic | neutral | non-polar | polar | non-polar | 6.02 | -1.771 | -0.631 | 6.78299 | -2.963 | -0.11 | 95 | 95 | -1.214 | 9 | 9 | 0 | 0 | strand | -0.933333333333333 | 8.14 | 0.0211297973264338 | 156.233890214797 | 156.233722233267 | 156.382472756358 | 1333.51093453962 | 38 | -2 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 6 | 2 | 4 | 0 | 0 | 0 | 0 | 0 | -8 | 2 | -6 | -4 | 0 | 0 | 2 | 0 | -0.448581560283688 | -0.163049095607235 | 0.247051260571537 | -0.505200341005968 | -0.0287958115183246 | 1 | -1 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.229 | -1.201 | 9:9 | 147/150 | Q | 5.05135310548255 | 2.49562215648785e-55 | 0.322395320006857 | 15.6681961306855 | 87.7376148601903 | 314.979076956589 | 2.19377524680641 | 1.27822918710216e-207 | 206.893391269988 | 83.6783303393677 | 330.782028899935 | 5.90060424845557e-292 | lineage4 | dr_mutations_pyrazinamide | PRO | 0 | ERR760881 | ERR760881 | lineage4.1.2.1 | ar | Argentina | pnca_p.gln10pro | A | B | GLN | QA10 | pnca_complex.pdb |
489 | Q10P | L1 | PZA | Q | Q10 | 10 | P | NA | MDR | DM | hydrophilic | hydrophilic | neutral | non-polar | polar | non-polar | 6.02 | -1.771 | -0.631 | 6.78299 | -2.963 | -0.11 | 95 | 95 | -1.214 | 9 | 9 | 0 | 0 | strand | -0.933333333333333 | 8.14 | 0.0211297973264338 | 156.233890214797 | 156.233722233267 | 156.382472756358 | 1333.51093453962 | 38 | -2 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 6 | 2 | 4 | 0 | 0 | 0 | 0 | 0 | -8 | 2 | -6 | -4 | 0 | 0 | 2 | 0 | -0.448581560283688 | -0.163049095607235 | 0.247051260571537 | -0.505200341005968 | -0.0287958115183246 | 1 | -1 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.229 | -1.201 | 9:9 | 147/150 | Q | 5.05135310548255 | 2.49562215648785e-55 | 0.322395320006857 | 15.6681961306855 | 87.7376148601903 | 314.979076956589 | 2.19377524680641 | 1.27822918710216e-207 | 206.893391269988 | 83.6783303393677 | 330.782028899935 | 5.90060424845557e-292 | lineage1 | dr_mutations_pyrazinamide | PRO | 0 | SRR8380876 | SRR8380876 | lineage1.1.2 | in | India | pnca_p.gln10pro | A | B | GLN | QA10 | pnca_complex.pdb |
490 | Q10P | L4 | PZA | Q | Q10 | 10 | P | 1 | Pre-XDR | DM | hydrophilic | hydrophilic | neutral | non-polar | polar | non-polar | 6.02 | -1.771 | -0.631 | 6.78299 | -2.963 | -0.11 | 95 | 95 | -1.214 | 9 | 9 | 0 | 0 | strand | -0.933333333333333 | 8.14 | 0.0211297973264338 | 156.233890214797 | 156.233722233267 | 156.382472756358 | 1333.51093453962 | 38 | -2 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 6 | 2 | 4 | 0 | 0 | 0 | 0 | 0 | -8 | 2 | -6 | -4 | 0 | 0 | 2 | 0 | -0.448581560283688 | -0.163049095607235 | 0.247051260571537 | -0.505200341005968 | -0.0287958115183246 | 1 | -1 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.229 | -1.201 | 9:9 | 147/150 | Q | 5.05135310548255 | 2.49562215648785e-55 | 0.322395320006857 | 15.6681961306855 | 87.7376148601903 | 314.979076956589 | 2.19377524680641 | 1.27822918710216e-207 | 206.893391269988 | 83.6783303393677 | 330.782028899935 | 5.90060424845557e-292 | lineage4 | dr_mutations_pyrazinamide | PRO | 0 | ERR757162 | ERR757162 | lineage4.1.2.1 | ar | Argentina | pnca_p.gln10pro | A | B | GLN | QA10 | pnca_complex.pdb |
491 | Q10P | L4 | PZA | Q | Q10 | 10 | P | 1 | Pre-XDR | DM | hydrophilic | hydrophilic | neutral | non-polar | polar | non-polar | 6.02 | -1.771 | -0.631 | 6.78299 | -2.963 | -0.11 | 95 | 95 | -1.214 | 9 | 9 | 0 | 0 | strand | -0.933333333333333 | 8.14 | 0.0211297973264338 | 156.233890214797 | 156.233722233267 | 156.382472756358 | 1333.51093453962 | 38 | -2 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 6 | 2 | 4 | 0 | 0 | 0 | 0 | 0 | -8 | 2 | -6 | -4 | 0 | 0 | 2 | 0 | -0.448581560283688 | -0.163049095607235 | 0.247051260571537 | -0.505200341005968 | -0.0287958115183246 | 1 | -1 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.229 | -1.201 | 9:9 | 147/150 | Q | 5.05135310548255 | 2.49562215648785e-55 | 0.322395320006857 | 15.6681961306855 | 87.7376148601903 | 314.979076956589 | 2.19377524680641 | 1.27822918710216e-207 | 206.893391269988 | 83.6783303393677 | 330.782028899935 | 5.90060424845557e-292 | lineage4 | dr_mutations_pyrazinamide | PRO | 0 | ERR760738 | ERR760738 | lineage4.1.2.1 | ar | Argentina | pnca_p.gln10pro | A | B | GLN | QA10 | pnca_complex.pdb |
492 | Q10P | L4 | PZA | Q | Q10 | 10 | P | 1 | Pre-XDR | DM | hydrophilic | hydrophilic | neutral | non-polar | polar | non-polar | 6.02 | -1.771 | -0.631 | 6.78299 | -2.963 | -0.11 | 95 | 95 | -1.214 | 9 | 9 | 0 | 0 | strand | -0.933333333333333 | 8.14 | 0.0211297973264338 | 156.233890214797 | 156.233722233267 | 156.382472756358 | 1333.51093453962 | 38 | -2 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 6 | 2 | 4 | 0 | 0 | 0 | 0 | 0 | -8 | 2 | -6 | -4 | 0 | 0 | 2 | 0 | -0.448581560283688 | -0.163049095607235 | 0.247051260571537 | -0.505200341005968 | -0.0287958115183246 | 1 | -1 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.229 | -1.201 | 9:9 | 147/150 | Q | 5.05135310548255 | 2.49562215648785e-55 | 0.322395320006857 | 15.6681961306855 | 87.7376148601903 | 314.979076956589 | 2.19377524680641 | 1.27822918710216e-207 | 206.893391269988 | 83.6783303393677 | 330.782028899935 | 5.90060424845557e-292 | lineage4 | dr_mutations_pyrazinamide | PRO | 0 | ERR760822 | ERR760822 | lineage4.1.2.1 | ar | Argentina | pnca_p.gln10pro | A | B | GLN | QA10 | pnca_complex.pdb |
493 | Q10P | L4 | PZA | Q | Q10 | 10 | P | 1 | XDR | DM | hydrophilic | hydrophilic | neutral | non-polar | polar | non-polar | 6.02 | -1.771 | -0.631 | 6.78299 | -2.963 | -0.11 | 95 | 95 | -1.214 | 9 | 9 | 0 | 0 | strand | -0.933333333333333 | 8.14 | 0.0211297973264338 | 156.233890214797 | 156.233722233267 | 156.382472756358 | 1333.51093453962 | 38 | -2 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 6 | 2 | 4 | 0 | 0 | 0 | 0 | 0 | -8 | 2 | -6 | -4 | 0 | 0 | 2 | 0 | -0.448581560283688 | -0.163049095607235 | 0.247051260571537 | -0.505200341005968 | -0.0287958115183246 | 1 | -1 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.229 | -1.201 | 9:9 | 147/150 | Q | 5.05135310548255 | 2.49562215648785e-55 | 0.322395320006857 | 15.6681961306855 | 87.7376148601903 | 314.979076956589 | 2.19377524680641 | 1.27822918710216e-207 | 206.893391269988 | 83.6783303393677 | 330.782028899935 | 5.90060424845557e-292 | lineage4 | dr_mutations_pyrazinamide | PRO | 0 | ERR760795 | ERR760795 | lineage4.1.2.1 | ar | Argentina | pnca_p.gln10pro | A | B | GLN | QA10 | pnca_complex.pdb |
494 | Q10P | L4 | PZA | Q | Q10 | 10 | P | 1 | Pre-XDR | DM | hydrophilic | hydrophilic | neutral | non-polar | polar | non-polar | 6.02 | -1.771 | -0.631 | 6.78299 | -2.963 | -0.11 | 95 | 95 | -1.214 | 9 | 9 | 0 | 0 | strand | -0.933333333333333 | 8.14 | 0.0211297973264338 | 156.233890214797 | 156.233722233267 | 156.382472756358 | 1333.51093453962 | 38 | -2 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 6 | 2 | 4 | 0 | 0 | 0 | 0 | 0 | -8 | 2 | -6 | -4 | 0 | 0 | 2 | 0 | -0.448581560283688 | -0.163049095607235 | 0.247051260571537 | -0.505200341005968 | -0.0287958115183246 | 1 | -1 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.229 | -1.201 | 9:9 | 147/150 | Q | 5.05135310548255 | 2.49562215648785e-55 | 0.322395320006857 | 15.6681961306855 | 87.7376148601903 | 314.979076956589 | 2.19377524680641 | 1.27822918710216e-207 | 206.893391269988 | 83.6783303393677 | 330.782028899935 | 5.90060424845557e-292 | lineage4 | dr_mutations_pyrazinamide | PRO | 0 | ERR760799 | ERR760799 | lineage4.1.2.1 | ar | Argentina | pnca_p.gln10pro | A | B | GLN | QA10 | pnca_complex.pdb |
495 | Q10P | L2 | PZA | Q | Q10 | 10 | P | 1 | MDR | DM | hydrophilic | hydrophilic | neutral | non-polar | polar | non-polar | 6.02 | -1.771 | -0.631 | 6.78299 | -2.963 | -0.11 | 95 | 95 | -1.214 | 9 | 9 | 0 | 0 | strand | -0.933333333333333 | 8.14 | 0.0211297973264338 | 156.233890214797 | 156.233722233267 | 156.382472756358 | 1333.51093453962 | 38 | -2 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 6 | 2 | 4 | 0 | 0 | 0 | 0 | 0 | -8 | 2 | -6 | -4 | 0 | 0 | 2 | 0 | -0.448581560283688 | -0.163049095607235 | 0.247051260571537 | -0.505200341005968 | -0.0287958115183246 | 1 | -1 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.229 | -1.201 | 9:9 | 147/150 | Q | 5.05135310548255 | 2.49562215648785e-55 | 0.322395320006857 | 15.6681961306855 | 87.7376148601903 | 314.979076956589 | 2.19377524680641 | 1.27822918710216e-207 | 206.893391269988 | 83.6783303393677 | 330.782028899935 | 5.90060424845557e-292 | lineage2 | dr_mutations_pyrazinamide | PRO | 0 | SAMEA2534067,ERS457469 | ERR551610_ERR551611 | lineage2.2.1 | uz | Nukus | pnca_p.gln10pro | A | B | GLN | QA10 | pnca_complex.pdb |
496 | Q10P | L4 | PZA | Q | Q10 | 10 | P | 1 | Pre-XDR | DM | hydrophilic | hydrophilic | neutral | non-polar | polar | non-polar | 6.02 | -1.771 | -0.631 | 6.78299 | -2.963 | -0.11 | 95 | 95 | -1.214 | 9 | 9 | 0 | 0 | strand | -0.933333333333333 | 8.14 | 0.0211297973264338 | 156.233890214797 | 156.233722233267 | 156.382472756358 | 1333.51093453962 | 38 | -2 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 6 | 2 | 4 | 0 | 0 | 0 | 0 | 0 | -8 | 2 | -6 | -4 | 0 | 0 | 2 | 0 | -0.448581560283688 | -0.163049095607235 | 0.247051260571537 | -0.505200341005968 | -0.0287958115183246 | 1 | -1 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.229 | -1.201 | 9:9 | 147/150 | Q | 5.05135310548255 | 2.49562215648785e-55 | 0.322395320006857 | 15.6681961306855 | 87.7376148601903 | 314.979076956589 | 2.19377524680641 | 1.27822918710216e-207 | 206.893391269988 | 83.6783303393677 | 330.782028899935 | 5.90060424845557e-292 | lineage4 | dr_mutations_pyrazinamide | PRO | 0 | ERR760736 | ERR760736 | lineage4.1.2.1 | ar | Argentina | pnca_p.gln10pro | A | B | GLN | QA10 | pnca_complex.pdb |
497 | Q10P | L4 | PZA | Q | Q10 | 10 | P | 1 | Pre-XDR | DM | hydrophilic | hydrophilic | neutral | non-polar | polar | non-polar | 6.02 | -1.771 | -0.631 | 6.78299 | -2.963 | -0.11 | 95 | 95 | -1.214 | 9 | 9 | 0 | 0 | strand | -0.933333333333333 | 8.14 | 0.0211297973264338 | 156.233890214797 | 156.233722233267 | 156.382472756358 | 1333.51093453962 | 38 | -2 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 6 | 2 | 4 | 0 | 0 | 0 | 0 | 0 | -8 | 2 | -6 | -4 | 0 | 0 | 2 | 0 | -0.448581560283688 | -0.163049095607235 | 0.247051260571537 | -0.505200341005968 | -0.0287958115183246 | 1 | -1 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.229 | -1.201 | 9:9 | 147/150 | Q | 5.05135310548255 | 2.49562215648785e-55 | 0.322395320006857 | 15.6681961306855 | 87.7376148601903 | 314.979076956589 | 2.19377524680641 | 1.27822918710216e-207 | 206.893391269988 | 83.6783303393677 | 330.782028899935 | 5.90060424845557e-292 | lineage4 | dr_mutations_pyrazinamide | PRO | 0 | ERR757188 | ERR757188 | lineage4.1.2.1 | ar | Argentina | pnca_p.gln10pro | A | B | GLN | QA10 | pnca_complex.pdb |
498 | Q10P | L4 | PZA | Q | Q10 | 10 | P | 1 | Pre-XDR | DM | hydrophilic | hydrophilic | neutral | non-polar | polar | non-polar | 6.02 | -1.771 | -0.631 | 6.78299 | -2.963 | -0.11 | 95 | 95 | -1.214 | 9 | 9 | 0 | 0 | strand | -0.933333333333333 | 8.14 | 0.0211297973264338 | 156.233890214797 | 156.233722233267 | 156.382472756358 | 1333.51093453962 | 38 | -2 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 6 | 2 | 4 | 0 | 0 | 0 | 0 | 0 | -8 | 2 | -6 | -4 | 0 | 0 | 2 | 0 | -0.448581560283688 | -0.163049095607235 | 0.247051260571537 | -0.505200341005968 | -0.0287958115183246 | 1 | -1 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.229 | -1.201 | 9:9 | 147/150 | Q | 5.05135310548255 | 2.49562215648785e-55 | 0.322395320006857 | 15.6681961306855 | 87.7376148601903 | 314.979076956589 | 2.19377524680641 | 1.27822918710216e-207 | 206.893391269988 | 83.6783303393677 | 330.782028899935 | 5.90060424845557e-292 | lineage4 | dr_mutations_pyrazinamide | PRO | 0 | ERR760902 | ERR760902 | lineage4.1.2.1 | ar | Argentina | pnca_p.gln10pro | A | B | GLN | QA10 | pnca_complex.pdb |
499 | Q10P | L4 | PZA | Q | Q10 | 10 | P | 1 | Pre-XDR | DM | hydrophilic | hydrophilic | neutral | non-polar | polar | non-polar | 6.02 | -1.771 | -0.631 | 6.78299 | -2.963 | -0.11 | 95 | 95 | -1.214 | 9 | 9 | 0 | 0 | strand | -0.933333333333333 | 8.14 | 0.0211297973264338 | 156.233890214797 | 156.233722233267 | 156.382472756358 | 1333.51093453962 | 38 | -2 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 6 | 2 | 4 | 0 | 0 | 0 | 0 | 0 | -8 | 2 | -6 | -4 | 0 | 0 | 2 | 0 | -0.448581560283688 | -0.163049095607235 | 0.247051260571537 | -0.505200341005968 | -0.0287958115183246 | 1 | -1 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.229 | -1.201 | 9:9 | 147/150 | Q | 5.05135310548255 | 2.49562215648785e-55 | 0.322395320006857 | 15.6681961306855 | 87.7376148601903 | 314.979076956589 | 2.19377524680641 | 1.27822918710216e-207 | 206.893391269988 | 83.6783303393677 | 330.782028899935 | 5.90060424845557e-292 | lineage4 | dr_mutations_pyrazinamide | PRO | 0 | ERR760916 | ERR760916 | lineage4.1.2.1 | ar | Argentina | pnca_p.gln10pro | A | B | GLN | QA10 | pnca_complex.pdb |
500 | Q10P | L4 | PZA | Q | Q10 | 10 | P | NA | MDR | DM | hydrophilic | hydrophilic | neutral | non-polar | polar | non-polar | 6.02 | -1.771 | -0.631 | 6.78299 | -2.963 | -0.11 | 95 | 95 | -1.214 | 9 | 9 | 0 | 0 | strand | -0.933333333333333 | 8.14 | 0.0211297973264338 | 156.233890214797 | 156.233722233267 | 156.382472756358 | 1333.51093453962 | 38 | -2 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 6 | 2 | 4 | 0 | 0 | 0 | 0 | 0 | -8 | 2 | -6 | -4 | 0 | 0 | 2 | 0 | -0.448581560283688 | -0.163049095607235 | 0.247051260571537 | -0.505200341005968 | -0.0287958115183246 | 1 | -1 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.229 | -1.201 | 9:9 | 147/150 | Q | 5.05135310548255 | 2.49562215648785e-55 | 0.322395320006857 | 15.6681961306855 | 87.7376148601903 | 314.979076956589 | 2.19377524680641 | 1.27822918710216e-207 | 206.893391269988 | 83.6783303393677 | 330.782028899935 | 5.90060424845557e-292 | lineage4 | dr_mutations_pyrazinamide | PRO | 0 | ERR1023472 | ERR1023472 | lineage4.3.2.1 | | | pnca_p.gln10pro | A | B | GLN | QA10 | pnca_complex.pdb |
501 | Q10P | L2 | PZA | Q | Q10 | 10 | P | 1 | MDR | DM | hydrophilic | hydrophilic | neutral | non-polar | polar | non-polar | 6.02 | -1.771 | -0.631 | 6.78299 | -2.963 | -0.11 | 95 | 95 | -1.214 | 9 | 9 | 0 | 0 | strand | -0.933333333333333 | 8.14 | 0.0211297973264338 | 156.233890214797 | 156.233722233267 | 156.382472756358 | 1333.51093453962 | 38 | -2 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 6 | 2 | 4 | 0 | 0 | 0 | 0 | 0 | -8 | 2 | -6 | -4 | 0 | 0 | 2 | 0 | -0.448581560283688 | -0.163049095607235 | 0.247051260571537 | -0.505200341005968 | -0.0287958115183246 | 1 | -1 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.229 | -1.201 | 9:9 | 147/150 | Q | 5.05135310548255 | 2.49562215648785e-55 | 0.322395320006857 | 15.6681961306855 | 87.7376148601903 | 314.979076956589 | 2.19377524680641 | 1.27822918710216e-207 | 206.893391269988 | 83.6783303393677 | 330.782028899935 | 5.90060424845557e-292 | lineage2 | dr_mutations_pyrazinamide | PRO | 0 | ERS458053,SAMEA2534651,ERR552441 | ERR552441 | lineage2.2.1 | uz | Nukus | pnca_p.gln10pro | A | B | GLN | QA10 | pnca_complex.pdb |
502 | Q10P | L4 | PZA | Q | Q10 | 10 | P | 1 | Pre-XDR | DM | hydrophilic | hydrophilic | neutral | non-polar | polar | non-polar | 6.02 | -1.771 | -0.631 | 6.78299 | -2.963 | -0.11 | 95 | 95 | -1.214 | 9 | 9 | 0 | 0 | strand | -0.933333333333333 | 8.14 | 0.0211297973264338 | 156.233890214797 | 156.233722233267 | 156.382472756358 | 1333.51093453962 | 38 | -2 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 6 | 2 | 4 | 0 | 0 | 0 | 0 | 0 | -8 | 2 | -6 | -4 | 0 | 0 | 2 | 0 | -0.448581560283688 | -0.163049095607235 | 0.247051260571537 | -0.505200341005968 | -0.0287958115183246 | 1 | -1 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.229 | -1.201 | 9:9 | 147/150 | Q | 5.05135310548255 | 2.49562215648785e-55 | 0.322395320006857 | 15.6681961306855 | 87.7376148601903 | 314.979076956589 | 2.19377524680641 | 1.27822918710216e-207 | 206.893391269988 | 83.6783303393677 | 330.782028899935 | 5.90060424845557e-292 | lineage4 | dr_mutations_pyrazinamide | PRO | 0 | ERR760846 | ERR760846 | lineage4.1.2.1 | ar | Argentina | pnca_p.gln10pro | A | B | GLN | QA10 | pnca_complex.pdb |
503 | Q10P | L2 | PZA | Q | Q10 | 10 | P | 1 | MDR | DM | hydrophilic | hydrophilic | neutral | non-polar | polar | non-polar | 6.02 | -1.771 | -0.631 | 6.78299 | -2.963 | -0.11 | 95 | 95 | -1.214 | 9 | 9 | 0 | 0 | strand | -0.933333333333333 | 8.14 | 0.0211297973264338 | 156.233890214797 | 156.233722233267 | 156.382472756358 | 1333.51093453962 | 38 | -2 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 6 | 2 | 4 | 0 | 0 | 0 | 0 | 0 | -8 | 2 | -6 | -4 | 0 | 0 | 2 | 0 | -0.448581560283688 | -0.163049095607235 | 0.247051260571537 | -0.505200341005968 | -0.0287958115183246 | 1 | -1 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.229 | -1.201 | 9:9 | 147/150 | Q | 5.05135310548255 | 2.49562215648785e-55 | 0.322395320006857 | 15.6681961306855 | 87.7376148601903 | 314.979076956589 | 2.19377524680641 | 1.27822918710216e-207 | 206.893391269988 | 83.6783303393677 | 330.782028899935 | 5.90060424845557e-292 | lineage2 | dr_mutations_pyrazinamide | PRO | 0 | ERS457589,SAMEA2534187 | ERR551780_ERR551781 | lineage2.2.1 | uz | Nukus | pnca_p.gln10pro | A | B | GLN | QA10 | pnca_complex.pdb |
504 | Q10P | L4 | PZA | Q | Q10 | 10 | P | 1 | Pre-XDR | DM | hydrophilic | hydrophilic | neutral | non-polar | polar | non-polar | 6.02 | -1.771 | -0.631 | 6.78299 | -2.963 | -0.11 | 95 | 95 | -1.214 | 9 | 9 | 0 | 0 | strand | -0.933333333333333 | 8.14 | 0.0211297973264338 | 156.233890214797 | 156.233722233267 | 156.382472756358 | 1333.51093453962 | 38 | -2 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 6 | 2 | 4 | 0 | 0 | 0 | 0 | 0 | -8 | 2 | -6 | -4 | 0 | 0 | 2 | 0 | -0.448581560283688 | -0.163049095607235 | 0.247051260571537 | -0.505200341005968 | -0.0287958115183246 | 1 | -1 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.229 | -1.201 | 9:9 | 147/150 | Q | 5.05135310548255 | 2.49562215648785e-55 | 0.322395320006857 | 15.6681961306855 | 87.7376148601903 | 314.979076956589 | 2.19377524680641 | 1.27822918710216e-207 | 206.893391269988 | 83.6783303393677 | 330.782028899935 | 5.90060424845557e-292 | lineage4 | dr_mutations_pyrazinamide | PRO | 0 | ERR757178 | ERR757178 | lineage4.1.2.1 | ar | Argentina | pnca_p.gln10pro | A | B | GLN | QA10 | pnca_complex.pdb |
505 | Q10P | L4 | PZA | Q | Q10 | 10 | P | 1 | Pre-XDR | DM | hydrophilic | hydrophilic | neutral | non-polar | polar | non-polar | 6.02 | -1.771 | -0.631 | 6.78299 | -2.963 | -0.11 | 95 | 95 | -1.214 | 9 | 9 | 0 | 0 | strand | -0.933333333333333 | 8.14 | 0.0211297973264338 | 156.233890214797 | 156.233722233267 | 156.382472756358 | 1333.51093453962 | 38 | -2 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 6 | 2 | 4 | 0 | 0 | 0 | 0 | 0 | -8 | 2 | -6 | -4 | 0 | 0 | 2 | 0 | -0.448581560283688 | -0.163049095607235 | 0.247051260571537 | -0.505200341005968 | -0.0287958115183246 | 1 | -1 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.229 | -1.201 | 9:9 | 147/150 | Q | 5.05135310548255 | 2.49562215648785e-55 | 0.322395320006857 | 15.6681961306855 | 87.7376148601903 | 314.979076956589 | 2.19377524680641 | 1.27822918710216e-207 | 206.893391269988 | 83.6783303393677 | 330.782028899935 | 5.90060424845557e-292 | lineage4 | dr_mutations_pyrazinamide | PRO | 0 | ERR760739 | ERR760739 | lineage4.1.2.1 | ar | Argentina | pnca_p.gln10pro | A | B | GLN | QA10 | pnca_complex.pdb |
506 | Q10P | L2 | PZA | Q | Q10 | 10 | P | 1 | MDR | DM | hydrophilic | hydrophilic | neutral | non-polar | polar | non-polar | 6.02 | -1.771 | -0.631 | 6.78299 | -2.963 | -0.11 | 95 | 95 | -1.214 | 9 | 9 | 0 | 0 | strand | -0.933333333333333 | 8.14 | 0.0211297973264338 | 156.233890214797 | 156.233722233267 | 156.382472756358 | 1333.51093453962 | 38 | -2 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 6 | 2 | 4 | 0 | 0 | 0 | 0 | 0 | -8 | 2 | -6 | -4 | 0 | 0 | 2 | 0 | -0.448581560283688 | -0.163049095607235 | 0.247051260571537 | -0.505200341005968 | -0.0287958115183246 | 1 | -1 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.229 | -1.201 | 9:9 | 147/150 | Q | 5.05135310548255 | 2.49562215648785e-55 | 0.322395320006857 | 15.6681961306855 | 87.7376148601903 | 314.979076956589 | 2.19377524680641 | 1.27822918710216e-207 | 206.893391269988 | 83.6783303393677 | 330.782028899935 | 5.90060424845557e-292 | lineage2 | dr_mutations_pyrazinamide | PRO | 0 | ERS457017,SAMEA2533615 | ERR550988_ERR550989_ERR550990 | lineage2.2.1 | uz | Nukus | pnca_p.gln10pro | A | B | GLN | QA10 | pnca_complex.pdb |
507 | Q10P | L4 | PZA | Q | Q10 | 10 | P | 1 | Pre-XDR | DM | hydrophilic | hydrophilic | neutral | non-polar | polar | non-polar | 6.02 | -1.771 | -0.631 | 6.78299 | -2.963 | -0.11 | 95 | 95 | -1.214 | 9 | 9 | 0 | 0 | strand | -0.933333333333333 | 8.14 | 0.0211297973264338 | 156.233890214797 | 156.233722233267 | 156.382472756358 | 1333.51093453962 | 38 | -2 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 6 | 2 | 4 | 0 | 0 | 0 | 0 | 0 | -8 | 2 | -6 | -4 | 0 | 0 | 2 | 0 | -0.448581560283688 | -0.163049095607235 | 0.247051260571537 | -0.505200341005968 | -0.0287958115183246 | 1 | -1 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.229 | -1.201 | 9:9 | 147/150 | Q | 5.05135310548255 | 2.49562215648785e-55 | 0.322395320006857 | 15.6681961306855 | 87.7376148601903 | 314.979076956589 | 2.19377524680641 | 1.27822918710216e-207 | 206.893391269988 | 83.6783303393677 | 330.782028899935 | 5.90060424845557e-292 | lineage4 | dr_mutations_pyrazinamide | PRO | 0 | ERR760836 | ERR760836 | lineage4.1.2.1 | ar | Argentina | pnca_p.gln10pro | A | B | GLN | QA10 | pnca_complex.pdb |
508 | Q10P | L4 | PZA | Q | Q10 | 10 | P | NA | Pre-XDR | DM | hydrophilic | hydrophilic | neutral | non-polar | polar | non-polar | 6.02 | -1.771 | -0.631 | 6.78299 | -2.963 | -0.11 | 95 | 95 | -1.214 | 9 | 9 | 0 | 0 | strand | -0.933333333333333 | 8.14 | 0.0211297973264338 | 156.233890214797 | 156.233722233267 | 156.382472756358 | 1333.51093453962 | 38 | -2 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 6 | 2 | 4 | 0 | 0 | 0 | 0 | 0 | -8 | 2 | -6 | -4 | 0 | 0 | 2 | 0 | -0.448581560283688 | -0.163049095607235 | 0.247051260571537 | -0.505200341005968 | -0.0287958115183246 | 1 | -1 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.229 | -1.201 | 9:9 | 147/150 | Q | 5.05135310548255 | 2.49562215648785e-55 | 0.322395320006857 | 15.6681961306855 | 87.7376148601903 | 314.979076956589 | 2.19377524680641 | 1.27822918710216e-207 | 206.893391269988 | 83.6783303393677 | 330.782028899935 | 5.90060424845557e-292 | lineage4 | dr_mutations_pyrazinamide | PRO | 0 | ERR1035005 | ERR1035005 | lineage4.4.1.1 | za | South Africa | pnca_p.gln10pro | A | B | GLN | QA10 | pnca_complex.pdb |
509 | Q10P | L2 | PZA | Q | Q10 | 10 | P | 1 | MDR | DM | hydrophilic | hydrophilic | neutral | non-polar | polar | non-polar | 6.02 | -1.771 | -0.631 | 6.78299 | -2.963 | -0.11 | 95 | 95 | -1.214 | 9 | 9 | 0 | 0 | strand | -0.933333333333333 | 8.14 | 0.0211297973264338 | 156.233890214797 | 156.233722233267 | 156.382472756358 | 1333.51093453962 | 38 | -2 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 6 | 2 | 4 | 0 | 0 | 0 | 0 | 0 | -8 | 2 | -6 | -4 | 0 | 0 | 2 | 0 | -0.448581560283688 | -0.163049095607235 | 0.247051260571537 | -0.505200341005968 | -0.0287958115183246 | 1 | -1 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.229 | -1.201 | 9:9 | 147/150 | Q | 5.05135310548255 | 2.49562215648785e-55 | 0.322395320006857 | 15.6681961306855 | 87.7376148601903 | 314.979076956589 | 2.19377524680641 | 1.27822918710216e-207 | 206.893391269988 | 83.6783303393677 | 330.782028899935 | 5.90060424845557e-292 | lineage2 | dr_mutations_pyrazinamide | PRO | 0 | ERS458603 | ERR553189_ERR553188_ERR553190 | lineage2.2.1 | uz | Nukus | pnca_p.gln10pro | A | B | GLN | QA10 | pnca_complex.pdb |
510 | Q10P | L2 | PZA | Q | Q10 | 10 | P | 1 | MDR | DM | hydrophilic | hydrophilic | neutral | non-polar | polar | non-polar | 6.02 | -1.771 | -0.631 | 6.78299 | -2.963 | -0.11 | 95 | 95 | -1.214 | 9 | 9 | 0 | 0 | strand | -0.933333333333333 | 8.14 | 0.0211297973264338 | 156.233890214797 | 156.233722233267 | 156.382472756358 | 1333.51093453962 | 38 | -2 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 6 | 2 | 4 | 0 | 0 | 0 | 0 | 0 | -8 | 2 | -6 | -4 | 0 | 0 | 2 | 0 | -0.448581560283688 | -0.163049095607235 | 0.247051260571537 | -0.505200341005968 | -0.0287958115183246 | 1 | -1 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.229 | -1.201 | 9:9 | 147/150 | Q | 5.05135310548255 | 2.49562215648785e-55 | 0.322395320006857 | 15.6681961306855 | 87.7376148601903 | 314.979076956589 | 2.19377524680641 | 1.27822918710216e-207 | 206.893391269988 | 83.6783303393677 | 330.782028899935 | 5.90060424845557e-292 | lineage2 | dr_mutations_pyrazinamide | PRO | 0 | ERS457844 | ERR552144_ERR552143_ERR552142 | lineage2.2.1 | uz | Nukus | pnca_p.gln10pro | A | B | GLN | QA10 | pnca_complex.pdb |
511 | Q10P | L4 | PZA | Q | Q10 | 10 | P | 1 | XDR | DM | hydrophilic | hydrophilic | neutral | non-polar | polar | non-polar | 6.02 | -1.771 | -0.631 | 6.78299 | -2.963 | -0.11 | 95 | 95 | -1.214 | 9 | 9 | 0 | 0 | strand | -0.933333333333333 | 8.14 | 0.0211297973264338 | 156.233890214797 | 156.233722233267 | 156.382472756358 | 1333.51093453962 | 38 | -2 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 6 | 2 | 4 | 0 | 0 | 0 | 0 | 0 | -8 | 2 | -6 | -4 | 0 | 0 | 2 | 0 | -0.448581560283688 | -0.163049095607235 | 0.247051260571537 | -0.505200341005968 | -0.0287958115183246 | 1 | -1 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.229 | -1.201 | 9:9 | 147/150 | Q | 5.05135310548255 | 2.49562215648785e-55 | 0.322395320006857 | 15.6681961306855 | 87.7376148601903 | 314.979076956589 | 2.19377524680641 | 1.27822918710216e-207 | 206.893391269988 | 83.6783303393677 | 330.782028899935 | 5.90060424845557e-292 | lineage4 | dr_mutations_pyrazinamide | PRO | 0 | ERR760896 | ERR760896 | lineage4.1.2.1 | ar | Argentina | pnca_p.gln10pro | A | B | GLN | QA10 | pnca_complex.pdb |
512 | Q10P | L2 | PZA | Q | Q10 | 10 | P | NA | Pre-MDR | DM | hydrophilic | hydrophilic | neutral | non-polar | polar | non-polar | 6.02 | -1.771 | -0.631 | 6.78299 | -2.963 | -0.11 | 95 | 95 | -1.214 | 9 | 9 | 0 | 0 | strand | -0.933333333333333 | 8.14 | 0.0211297973264338 | 156.233890214797 | 156.233722233267 | 156.382472756358 | 1333.51093453962 | 38 | -2 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 6 | 2 | 4 | 0 | 0 | 0 | 0 | 0 | -8 | 2 | -6 | -4 | 0 | 0 | 2 | 0 | -0.448581560283688 | -0.163049095607235 | 0.247051260571537 | -0.505200341005968 | -0.0287958115183246 | 1 | -1 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.229 | -1.201 | 9:9 | 147/150 | Q | 5.05135310548255 | 2.49562215648785e-55 | 0.322395320006857 | 15.6681961306855 | 87.7376148601903 | 314.979076956589 | 2.19377524680641 | 1.27822918710216e-207 | 206.893391269988 | 83.6783303393677 | 330.782028899935 | 5.90060424845557e-292 | lineage2 | dr_mutations_pyrazinamide | PRO | 0 | 0932P-sc-2011-09-07T13:19:25Z-1276485,ERR067638 | ERR067638 | lineage2.2.1 | ru | Russia | pnca_p.gln10pro | A | B | GLN | QA10 | pnca_complex.pdb |
513 | Q10P | L4 | PZA | Q | Q10 | 10 | P | 1 | Pre-XDR | DM | hydrophilic | hydrophilic | neutral | non-polar | polar | non-polar | 6.02 | -1.771 | -0.631 | 6.78299 | -2.963 | -0.11 | 95 | 95 | -1.214 | 9 | 9 | 0 | 0 | strand | -0.933333333333333 | 8.14 | 0.0211297973264338 | 156.233890214797 | 156.233722233267 | 156.382472756358 | 1333.51093453962 | 38 | -2 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 6 | 2 | 4 | 0 | 0 | 0 | 0 | 0 | -8 | 2 | -6 | -4 | 0 | 0 | 2 | 0 | -0.448581560283688 | -0.163049095607235 | 0.247051260571537 | -0.505200341005968 | -0.0287958115183246 | 1 | -1 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.229 | -1.201 | 9:9 | 147/150 | Q | 5.05135310548255 | 2.49562215648785e-55 | 0.322395320006857 | 15.6681961306855 | 87.7376148601903 | 314.979076956589 | 2.19377524680641 | 1.27822918710216e-207 | 206.893391269988 | 83.6783303393677 | 330.782028899935 | 5.90060424845557e-292 | lineage4 | dr_mutations_pyrazinamide | PRO | 0 | ERR760764 | ERR760764 | lineage4.1.2.1 | ar | Argentina | pnca_p.gln10pro | A | B | GLN | QA10 | pnca_complex.pdb |
514 | Q10P | L2 | PZA | Q | Q10 | 10 | P | NA | Pre-XDR | DM | hydrophilic | hydrophilic | neutral | non-polar | polar | non-polar | 6.02 | -1.771 | -0.631 | 6.78299 | -2.963 | -0.11 | 95 | 95 | -1.214 | 9 | 9 | 0 | 0 | strand | -0.933333333333333 | 8.14 | 0.0211297973264338 | 156.233890214797 | 156.233722233267 | 156.382472756358 | 1333.51093453962 | 38 | -2 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 6 | 2 | 4 | 0 | 0 | 0 | 0 | 0 | -8 | 2 | -6 | -4 | 0 | 0 | 2 | 0 | -0.448581560283688 | -0.163049095607235 | 0.247051260571537 | -0.505200341005968 | -0.0287958115183246 | 1 | -1 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.229 | -1.201 | 9:9 | 147/150 | Q | 5.05135310548255 | 2.49562215648785e-55 | 0.322395320006857 | 15.6681961306855 | 87.7376148601903 | 314.979076956589 | 2.19377524680641 | 1.27822918710216e-207 | 206.893391269988 | 83.6783303393677 | 330.782028899935 | 5.90060424845557e-292 | lineage2 | dr_mutations_pyrazinamide | PRO | 0 | SRS797090 | SRR1723595_SRR1723596 | lineage2.2.1 | cn | China:Jiangxi | pnca_p.gln10pro | A | B | GLN | QA10 | pnca_complex.pdb |
515 | Q10P | L2 | PZA | Q | Q10 | 10 | P | 1 | Pre-XDR | DM | hydrophilic | hydrophilic | neutral | non-polar | polar | non-polar | 6.02 | -1.771 | -0.631 | 6.78299 | -2.963 | -0.11 | 95 | 95 | -1.214 | 9 | 9 | 0 | 0 | strand | -0.933333333333333 | 8.14 | 0.0211297973264338 | 156.233890214797 | 156.233722233267 | 156.382472756358 | 1333.51093453962 | 38 | -2 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 6 | 2 | 4 | 0 | 0 | 0 | 0 | 0 | -8 | 2 | -6 | -4 | 0 | 0 | 2 | 0 | -0.448581560283688 | -0.163049095607235 | 0.247051260571537 | -0.505200341005968 | -0.0287958115183246 | 1 | -1 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.229 | -1.201 | 9:9 | 147/150 | Q | 5.05135310548255 | 2.49562215648785e-55 | 0.322395320006857 | 15.6681961306855 | 87.7376148601903 | 314.979076956589 | 2.19377524680641 | 1.27822918710216e-207 | 206.893391269988 | 83.6783303393677 | 330.782028899935 | 5.90060424845557e-292 | lineage2 | dr_mutations_pyrazinamide | PRO | 0 | ERS457881 | ERR552198_ERR552199_ERR552197_ERR552200 | lineage2.2.1 | uz | Nukus | pnca_p.gln10pro | A | B | GLN | QA10 | pnca_complex.pdb |
516 | Q10P | L4 | PZA | Q | Q10 | 10 | P | 1 | Pre-XDR | DM | hydrophilic | hydrophilic | neutral | non-polar | polar | non-polar | 6.02 | -1.771 | -0.631 | 6.78299 | -2.963 | -0.11 | 95 | 95 | -1.214 | 9 | 9 | 0 | 0 | strand | -0.933333333333333 | 8.14 | 0.0211297973264338 | 156.233890214797 | 156.233722233267 | 156.382472756358 | 1333.51093453962 | 38 | -2 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 6 | 2 | 4 | 0 | 0 | 0 | 0 | 0 | -8 | 2 | -6 | -4 | 0 | 0 | 2 | 0 | -0.448581560283688 | -0.163049095607235 | 0.247051260571537 | -0.505200341005968 | -0.0287958115183246 | 1 | -1 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.229 | -1.201 | 9:9 | 147/150 | Q | 5.05135310548255 | 2.49562215648785e-55 | 0.322395320006857 | 15.6681961306855 | 87.7376148601903 | 314.979076956589 | 2.19377524680641 | 1.27822918710216e-207 | 206.893391269988 | 83.6783303393677 | 330.782028899935 | 5.90060424845557e-292 | lineage4 | dr_mutations_pyrazinamide | PRO | 0 | ERR757175 | ERR757175 | lineage4.1.2.1 | ar | Argentina | pnca_p.gln10pro | A | B | GLN | QA10 | pnca_complex.pdb |
517 | Q10P | L4 | PZA | Q | Q10 | 10 | P | 1 | Pre-XDR | DM | hydrophilic | hydrophilic | neutral | non-polar | polar | non-polar | 6.02 | -1.771 | -0.631 | 6.78299 | -2.963 | -0.11 | 95 | 95 | -1.214 | 9 | 9 | 0 | 0 | strand | -0.933333333333333 | 8.14 | 0.0211297973264338 | 156.233890214797 | 156.233722233267 | 156.382472756358 | 1333.51093453962 | 38 | -2 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 6 | 2 | 4 | 0 | 0 | 0 | 0 | 0 | -8 | 2 | -6 | -4 | 0 | 0 | 2 | 0 | -0.448581560283688 | -0.163049095607235 | 0.247051260571537 | -0.505200341005968 | -0.0287958115183246 | 1 | -1 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.229 | -1.201 | 9:9 | 147/150 | Q | 5.05135310548255 | 2.49562215648785e-55 | 0.322395320006857 | 15.6681961306855 | 87.7376148601903 | 314.979076956589 | 2.19377524680641 | 1.27822918710216e-207 | 206.893391269988 | 83.6783303393677 | 330.782028899935 | 5.90060424845557e-292 | lineage4 | dr_mutations_pyrazinamide | PRO | 0 | ERR760864 | ERR760864 | lineage4.1.2.1 | ar | Argentina | pnca_p.gln10pro | A | B | GLN | QA10 | pnca_complex.pdb |
518 | Q10P | L2 | PZA | Q | Q10 | 10 | P | 0 | Pre-XDR | DM | hydrophilic | hydrophilic | neutral | non-polar | polar | non-polar | 6.02 | -1.771 | -0.631 | 6.78299 | -2.963 | -0.11 | 95 | 95 | -1.214 | 9 | 9 | 0 | 0 | strand | -0.933333333333333 | 8.14 | 0.0211297973264338 | 156.233890214797 | 156.233722233267 | 156.382472756358 | 1333.51093453962 | 38 | -2 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 6 | 2 | 4 | 0 | 0 | 0 | 0 | 0 | -8 | 2 | -6 | -4 | 0 | 0 | 2 | 0 | -0.448581560283688 | -0.163049095607235 | 0.247051260571537 | -0.505200341005968 | -0.0287958115183246 | 1 | -1 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.229 | -1.201 | 9:9 | 147/150 | Q | 5.05135310548255 | 2.49562215648785e-55 | 0.322395320006857 | 15.6681961306855 | 87.7376148601903 | 314.979076956589 | 2.19377524680641 | 1.27822918710216e-207 | 206.893391269988 | 83.6783303393677 | 330.782028899935 | 5.90060424845557e-292 | lineage2 | dr_mutations_pyrazinamide | PRO | 0 | ERS458645 | ERR553247_ERR553246 | lineage2.2.1 | uz | Nukus | pnca_p.gln10pro | A | B | GLN | QA10 | pnca_complex.pdb |
519 | Q10P | L4 | PZA | Q | Q10 | 10 | P | 1 | Pre-XDR | DM | hydrophilic | hydrophilic | neutral | non-polar | polar | non-polar | 6.02 | -1.771 | -0.631 | 6.78299 | -2.963 | -0.11 | 95 | 95 | -1.214 | 9 | 9 | 0 | 0 | strand | -0.933333333333333 | 8.14 | 0.0211297973264338 | 156.233890214797 | 156.233722233267 | 156.382472756358 | 1333.51093453962 | 38 | -2 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 6 | 2 | 4 | 0 | 0 | 0 | 0 | 0 | -8 | 2 | -6 | -4 | 0 | 0 | 2 | 0 | -0.448581560283688 | -0.163049095607235 | 0.247051260571537 | -0.505200341005968 | -0.0287958115183246 | 1 | -1 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.229 | -1.201 | 9:9 | 147/150 | Q | 5.05135310548255 | 2.49562215648785e-55 | 0.322395320006857 | 15.6681961306855 | 87.7376148601903 | 314.979076956589 | 2.19377524680641 | 1.27822918710216e-207 | 206.893391269988 | 83.6783303393677 | 330.782028899935 | 5.90060424845557e-292 | lineage4 | dr_mutations_pyrazinamide | PRO | 0 | ERR760747 | ERR760747 | lineage4.1.2.1 | ar | Argentina | pnca_p.gln10pro | A | B | GLN | QA10 | pnca_complex.pdb |
520 | Q10P | L2 | PZA | Q | Q10 | 10 | P | 0 | MDR | DM | hydrophilic | hydrophilic | neutral | non-polar | polar | non-polar | 6.02 | -1.771 | -0.631 | 6.78299 | -2.963 | -0.11 | 95 | 95 | -1.214 | 9 | 9 | 0 | 0 | strand | -0.933333333333333 | 8.14 | 0.0211297973264338 | 156.233890214797 | 156.233722233267 | 156.382472756358 | 1333.51093453962 | 38 | -2 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 6 | 2 | 4 | 0 | 0 | 0 | 0 | 0 | -8 | 2 | -6 | -4 | 0 | 0 | 2 | 0 | -0.448581560283688 | -0.163049095607235 | 0.247051260571537 | -0.505200341005968 | -0.0287958115183246 | 1 | -1 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.229 | -1.201 | 9:9 | 147/150 | Q | 5.05135310548255 | 2.49562215648785e-55 | 0.322395320006857 | 15.6681961306855 | 87.7376148601903 | 314.979076956589 | 2.19377524680641 | 1.27822918710216e-207 | 206.893391269988 | 83.6783303393677 | 330.782028899935 | 5.90060424845557e-292 | lineage2 | dr_mutations_pyrazinamide | PRO | 0 | ERS458206 | ERR552661_ERR552660 | lineage2.2.1 | uz | Nukus | pnca_p.gln10pro | A | B | GLN | QA10 | pnca_complex.pdb |
521 | Q10P | L4 | PZA | Q | Q10 | 10 | P | 1 | Pre-XDR | DM | hydrophilic | hydrophilic | neutral | non-polar | polar | non-polar | 6.02 | -1.771 | -0.631 | 6.78299 | -2.963 | -0.11 | 95 | 95 | -1.214 | 9 | 9 | 0 | 0 | strand | -0.933333333333333 | 8.14 | 0.0211297973264338 | 156.233890214797 | 156.233722233267 | 156.382472756358 | 1333.51093453962 | 38 | -2 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 6 | 2 | 4 | 0 | 0 | 0 | 0 | 0 | -8 | 2 | -6 | -4 | 0 | 0 | 2 | 0 | -0.448581560283688 | -0.163049095607235 | 0.247051260571537 | -0.505200341005968 | -0.0287958115183246 | 1 | -1 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.229 | -1.201 | 9:9 | 147/150 | Q | 5.05135310548255 | 2.49562215648785e-55 | 0.322395320006857 | 15.6681961306855 | 87.7376148601903 | 314.979076956589 | 2.19377524680641 | 1.27822918710216e-207 | 206.893391269988 | 83.6783303393677 | 330.782028899935 | 5.90060424845557e-292 | lineage4 | dr_mutations_pyrazinamide | PRO | 0 | ERR757183 | ERR757183 | lineage4.1.2.1 | ar | Argentina | pnca_p.gln10pro | A | B | GLN | QA10 | pnca_complex.pdb |
522 | Q10P | L4 | PZA | Q | Q10 | 10 | P | 1 | Pre-XDR | DM | hydrophilic | hydrophilic | neutral | non-polar | polar | non-polar | 6.02 | -1.771 | -0.631 | 6.78299 | -2.963 | -0.11 | 95 | 95 | -1.214 | 9 | 9 | 0 | 0 | strand | -0.933333333333333 | 8.14 | 0.0211297973264338 | 156.233890214797 | 156.233722233267 | 156.382472756358 | 1333.51093453962 | 38 | -2 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 6 | 2 | 4 | 0 | 0 | 0 | 0 | 0 | -8 | 2 | -6 | -4 | 0 | 0 | 2 | 0 | -0.448581560283688 | -0.163049095607235 | 0.247051260571537 | -0.505200341005968 | -0.0287958115183246 | 1 | -1 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.229 | -1.201 | 9:9 | 147/150 | Q | 5.05135310548255 | 2.49562215648785e-55 | 0.322395320006857 | 15.6681961306855 | 87.7376148601903 | 314.979076956589 | 2.19377524680641 | 1.27822918710216e-207 | 206.893391269988 | 83.6783303393677 | 330.782028899935 | 5.90060424845557e-292 | lineage4 | dr_mutations_pyrazinamide | PRO | 0 | ERR760831 | ERR760831 | lineage4.1.2.1 | ar | Argentina | pnca_p.gln10pro | A | B | GLN | QA10 | pnca_complex.pdb |
523 | Q10P | L2 | PZA | Q | Q10 | 10 | P | NA | MDR | DM | hydrophilic | hydrophilic | neutral | non-polar | polar | non-polar | 6.02 | -1.771 | -0.631 | 6.78299 | -2.963 | -0.11 | 95 | 95 | -1.214 | 9 | 9 | 0 | 0 | strand | -0.933333333333333 | 8.14 | 0.0211297973264338 | 156.233890214797 | 156.233722233267 | 156.382472756358 | 1333.51093453962 | 38 | -2 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 6 | 2 | 4 | 0 | 0 | 0 | 0 | 0 | -8 | 2 | -6 | -4 | 0 | 0 | 2 | 0 | -0.448581560283688 | -0.163049095607235 | 0.247051260571537 | -0.505200341005968 | -0.0287958115183246 | 1 | -1 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.229 | -1.201 | 9:9 | 147/150 | Q | 5.05135310548255 | 2.49562215648785e-55 | 0.322395320006857 | 15.6681961306855 | 87.7376148601903 | 314.979076956589 | 2.19377524680641 | 1.27822918710216e-207 | 206.893391269988 | 83.6783303393677 | 330.782028899935 | 5.90060424845557e-292 | lineage2 | dr_mutations_pyrazinamide | PRO | 0 | BGI_SH068,SRR671811 | SRR671811 | lineage2.2.1 | cn | China | pnca_p.gln10pro | A | B | GLN | QA10 | pnca_complex.pdb |
524 | Q10P | L2 | PZA | Q | Q10 | 10 | P | 1 | MDR | DM | hydrophilic | hydrophilic | neutral | non-polar | polar | non-polar | 6.02 | -1.771 | -0.631 | 6.78299 | -2.963 | -0.11 | 95 | 95 | -1.214 | 9 | 9 | 0 | 0 | strand | -0.933333333333333 | 8.14 | 0.0211297973264338 | 156.233890214797 | 156.233722233267 | 156.382472756358 | 1333.51093453962 | 38 | -2 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 6 | 2 | 4 | 0 | 0 | 0 | 0 | 0 | -8 | 2 | -6 | -4 | 0 | 0 | 2 | 0 | -0.448581560283688 | -0.163049095607235 | 0.247051260571537 | -0.505200341005968 | -0.0287958115183246 | 1 | -1 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.229 | -1.201 | 9:9 | 147/150 | Q | 5.05135310548255 | 2.49562215648785e-55 | 0.322395320006857 | 15.6681961306855 | 87.7376148601903 | 314.979076956589 | 2.19377524680641 | 1.27822918710216e-207 | 206.893391269988 | 83.6783303393677 | 330.782028899935 | 5.90060424845557e-292 | lineage2 | dr_mutations_pyrazinamide | PRO | 0 | ERS457920,SAMEA2534518 | ERR552257_ERR552258 | lineage2.2.1 | uz | Nukus | pnca_p.gln10pro | A | B | GLN | QA10 | pnca_complex.pdb |
525 | Q10P | L4 | PZA | Q | Q10 | 10 | P | 1 | Pre-XDR | DM | hydrophilic | hydrophilic | neutral | non-polar | polar | non-polar | 6.02 | -1.771 | -0.631 | 6.78299 | -2.963 | -0.11 | 95 | 95 | -1.214 | 9 | 9 | 0 | 0 | strand | -0.933333333333333 | 8.14 | 0.0211297973264338 | 156.233890214797 | 156.233722233267 | 156.382472756358 | 1333.51093453962 | 38 | -2 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 6 | 2 | 4 | 0 | 0 | 0 | 0 | 0 | -8 | 2 | -6 | -4 | 0 | 0 | 2 | 0 | -0.448581560283688 | -0.163049095607235 | 0.247051260571537 | -0.505200341005968 | -0.0287958115183246 | 1 | -1 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.229 | -1.201 | 9:9 | 147/150 | Q | 5.05135310548255 | 2.49562215648785e-55 | 0.322395320006857 | 15.6681961306855 | 87.7376148601903 | 314.979076956589 | 2.19377524680641 | 1.27822918710216e-207 | 206.893391269988 | 83.6783303393677 | 330.782028899935 | 5.90060424845557e-292 | lineage4 | dr_mutations_pyrazinamide | PRO | 0 | ERR757167 | ERR757167 | lineage4.1.2.1 | ar | Argentina | pnca_p.gln10pro | A | B | GLN | QA10 | pnca_complex.pdb |
526 | Q10P | L4 | PZA | Q | Q10 | 10 | P | 1 | Pre-XDR | DM | hydrophilic | hydrophilic | neutral | non-polar | polar | non-polar | 6.02 | -1.771 | -0.631 | 6.78299 | -2.963 | -0.11 | 95 | 95 | -1.214 | 9 | 9 | 0 | 0 | strand | -0.933333333333333 | 8.14 | 0.0211297973264338 | 156.233890214797 | 156.233722233267 | 156.382472756358 | 1333.51093453962 | 38 | -2 | 0 | 0 | -2 | 0 | 0 | 0 | 0 | 6 | 2 | 4 | 0 | 0 | 0 | 0 | 0 | -8 | 2 | -6 | -4 | 0 | 0 | 2 | 0 | -0.448581560283688 | -0.163049095607235 | 0.247051260571537 | -0.505200341005968 | -0.0287958115183246 | 1 | -1 | Destabilising | Destabilising | Destabilising | Destabilising | Destabilising | effect | -1.229 | -1.201 | 9:9 | 147/150 | Q | 5.05135310548255 | 2.49562215648785e-55 | 0.322395320006857 | 15.6681961306855 | 87.7376148601903 | 314.979076956589 | 2.19377524680641 | 1.27822918710216e-207 | 206.893391269988 | 83.6783303393677 | 330.782028899935 | 5.90060424845557e-292 | lineage4 | dr_mutations_pyrazinamide | PRO | 0 | ERR760909 | ERR760909 | lineage4.1.2.1 | ar | Argentina | pnca_p.gln10pro | A | B | GLN | QA10 | pnca_complex.pdb |