4917 lines
4.6 MiB
4917 lines
4.6 MiB
"mutationinformation","lineage_labels","ligand_id","wild_type","wild_pos","position","mutant_type","pyrazinamide","drtype","mutation_info_labels","wt_prop_water","mut_prop_water","wt_prop_polarity","mut_prop_polarity","wt_calcprop","mut_calcprop","ligand_distance","ligand_affinity_change","duet_stability_change","ddg_foldx","deepddg","ddg_dynamut2","snap2_score","snap2_accuracy_pc","consurf_score","consurf_colour","consurf_colour_rev","asa","rsa","ss_class","kd_values","rd_values","af","or_mychisq","or_logistic","or_fisher","est_chisq","contacts","electro_rr","electro_mm","electro_sm","electro_ss","disulfide_rr","disulfide_mm","disulfide_sm","disulfide_ss","hbonds_rr","hbonds_mm","hbonds_sm","hbonds_ss","partcov_rr","partcov_mm","partcov_sm","partcov_ss","vdwclashes_rr","vdwclashes_mm","vdwclashes_sm","vdwclashes_ss","volumetric_rr","volumetric_mm","volumetric_sm","volumetric_ss","affinity_scaled","duet_scaled","foldx_scaled","deepddg_scaled","ddg_dynamut2_scaled","snap2_scaled","consurf_scaled","ligand_outcome","duet_outcome","foldx_outcome","deepddg_outcome","ddg_dynamut2_outcome","snap2_outcome","consurf_ci_upper","consurf_ci_lower","consurf_ci_colour","consurf_msa_data","consurf_aa_variety","beta_logistic","pval_logistic","se_logistic","zval_logistic","ci_low_logistic","ci_hi_logistic","log10_or_mychisq","pval_fisher","neglog_pval_fisher","ci_low_fisher","ci_hi_fisher","pval_chisq","lineage","mutation_info","mut_3upper","seq_offset4pdb","id","sample","sublineage","country_code","geographic_source","mutation","chain","ss","wt_3upper","wild_chain_pos","pdb_file"
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"M1I","L4","PZA","M","M1",1,"I",NA,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",23.978,-0.294,-0.347,-0.0549615,-0.407,-0.79,7,53,-1.048,9,9,88,0.392857142857143,"loop",0.633333333333333,4.12,0.0001437401178668,1.2119588062211,4.59700131334276e-05,0,1.01056822389159e-25,6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-3,0,-3,-3,0,0,0,0,-0.0744680851063829,-0.0896640826873385,-0.0105670806736907,-0.0693947144075021,-0.206806282722513,0.0736842105263158,-0.86326194398682,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.178,-0.993,"9:9","21/150","V:M",-9.98752126245056,0.942832958100734,139.277183325397,-0.0717096729269464,NA,144471.706314837,0.0834878586628579,1,0,0,25.8386585962163,0.999999999999746,"lineage4","other_mutations_pyrazinamide","ILE",0,"SAMN07236323,SRR5709866","SRR5709866","lineage4.4.2","th","Thailand","pnca_p.met1ile","A","-","MET","MA1","pnca_complex.pdb"
|
|
"M1I","L2","PZA","M","M1",1,"I",0,"MDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",23.978,-0.294,-0.347,-0.0549615,-0.407,-0.79,7,53,-1.048,9,9,88,0.392857142857143,"loop",0.633333333333333,4.12,0.0001437401178668,1.2119588062211,4.59700131334276e-05,0,1.01056822389159e-25,6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-3,0,-3,-3,0,0,0,0,-0.0744680851063829,-0.0896640826873385,-0.0105670806736907,-0.0693947144075021,-0.206806282722513,0.0736842105263158,-0.86326194398682,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.178,-0.993,"9:9","21/150","V:M",-9.98752126245056,0.942832958100734,139.277183325397,-0.0717096729269464,NA,144471.706314837,0.0834878586628579,1,0,0,25.8386585962163,0.999999999999746,"lineage2","other_mutations_pyrazinamide","ILE",0,"SAMEA2533466,ERS456868","ERR550784_ERR550785","lineage2.2.1","uz","Nukus","pnca_p.met1ile","A","-","MET","MA1","pnca_complex.pdb"
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|
"M1I","L2","PZA","M","M1",1,"I",0,"MDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",23.978,-0.294,-0.347,-0.0549615,-0.407,-0.79,7,53,-1.048,9,9,88,0.392857142857143,"loop",0.633333333333333,4.12,0.0001437401178668,1.2119588062211,4.59700131334276e-05,0,1.01056822389159e-25,6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-3,0,-3,-3,0,0,0,0,-0.0744680851063829,-0.0896640826873385,-0.0105670806736907,-0.0693947144075021,-0.206806282722513,0.0736842105263158,-0.86326194398682,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.178,-0.993,"9:9","21/150","V:M",-9.98752126245056,0.942832958100734,139.277183325397,-0.0717096729269464,NA,144471.706314837,0.0834878586628579,1,0,0,25.8386585962163,0.999999999999746,"lineage2","other_mutations_pyrazinamide","ILE",0,"ERS456961,SAMEA2533559","ERR550914_ERR550915","lineage2.2.1","uz","Nukus","pnca_p.met1ile","A","-","MET","MA1","pnca_complex.pdb"
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"M1K","L3","PZA","M","M1",1,"K",0,"MDR","OM","hydrophobic","hydrophobic","non-polar","basic","non-polar","pos",23.978,0.215,0.296,0.0794895,-1.017,-0.34,70,85,-1.048,9,9,88,0.392857142857143,"loop",0.633333333333333,4.12,7.18700589334483e-05,2.42412778478352,0.0001249735077034,0,1.03410070803344e-29,-6,-2,0,0,-18,0,0,0,0,0,0,0,-2,0,0,0,0,-1,0,-1,-1,0,0,0,0,0.0964125560538116,0.251700680272109,0.00289518061757443,-0.173401534526854,-0.0890052356020942,0.736842105263158,-0.86326194398682,"Stabilising","Stabilising","Destabilising","Destabilising","Destabilising","effect",-1.178,-0.993,"9:9","21/150","V:M",-8.98740878149642,0.940032862253633,119.468044435492,-0.0752285585987748,NA,4692673.51081395,0.384555509373631,1,0,0,188.544222231268,0.999999999999997,"lineage3","other_mutations_pyrazinamide","LYS",0,"ERR2510542","ERR2510542","lineage3","pk","Pakistan","pnca_p.met1lys","A","-","MET","MA1","pnca_complex.pdb"
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"M1R","L2","PZA","M","M1",1,"R",NA,"MDR","OM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",23.978,-0.16,0.694,-0.00977971,-0.78,1.21,44,71,-1.048,9,9,88,0.392857142857143,"loop",0.633333333333333,4.12,NA,NA,NA,NA,NA,-14,0,0,0,-20,0,0,0,0,-2,0,-2,0,0,0,0,0,1,0,-1,1,0,0,-2,-2,-0.0405268490374873,0.590136054421769,-0.00188027955087288,-0.132992327365729,0.679775280898876,0.463157894736842,-0.86326194398682,"Destabilising","Stabilising","Stabilising","Destabilising","Stabilising","effect",-1.178,-0.993,"9:9","21/150","V:M",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage2","other_mutations_pyrazinamide","ARG",0,"SRR5073787","SRR5073787","lineage2.2.1","vn","Vietnam","pnca_p.met1arg","A","-","MET","MA1","pnca_complex.pdb"
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"M1R","L4","PZA","M","M1",1,"R",NA,"MDR","OM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",23.978,-0.16,0.694,-0.00977971,-0.78,1.21,44,71,-1.048,9,9,88,0.392857142857143,"loop",0.633333333333333,4.12,NA,NA,NA,NA,NA,-14,0,0,0,-20,0,0,0,0,-2,0,-2,0,0,0,0,0,1,0,-1,1,0,0,-2,-2,-0.0405268490374873,0.590136054421769,-0.00188027955087288,-0.132992327365729,0.679775280898876,0.463157894736842,-0.86326194398682,"Destabilising","Stabilising","Stabilising","Destabilising","Stabilising","effect",-1.178,-0.993,"9:9","21/150","V:M",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage4","other_mutations_pyrazinamide","ARG",0,"ERR2707157","ERR2707157","lineage4.3.2","cd","Democratic Republic of Congo","pnca_p.met1arg","A","-","MET","MA1","pnca_complex.pdb"
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"M1T","L4","PZA","M","M1",1,"T",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",23.978,0.344,0.109,0.867771,-1.096,0.51,52,75,-1.048,9,9,88,0.392857142857143,"loop",0.633333333333333,4.12,0.0007187005893344,97.3828619670747,1395803.74890195,Inf,42.8452490786805,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,2,0,0,2,0,0,0,0,0.154260089686099,0.0926870748299319,0.031606108727482,-0.186871270247229,0.286516853932584,0.547368421052632,-0.86326194398682,"Stabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.178,-0.993,"9:9","21/150","V:M",14.1489809714062,0.890414731995374,102.692976014008,0.137779442378573,507.712885368923,NA,1.98848253379833,2.1018584548314e-08,7.67739653395739,10.9022485555592,Inf,5.92457926729285e-11,"lineage4","dr_mutations_pyrazinamide","THR",0,"ERR2515926","ERR2515926","lineage4.8","za","South Africa","pnca_p.met1thr","A","-","MET","MA1","pnca_complex.pdb"
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|
"M1T","L2","PZA","M","M1",1,"T",1,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",23.978,0.344,0.109,0.867771,-1.096,0.51,52,75,-1.048,9,9,88,0.392857142857143,"loop",0.633333333333333,4.12,0.0007187005893344,97.3828619670747,1395803.74890195,Inf,42.8452490786805,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,2,0,0,2,0,0,0,0,0.154260089686099,0.0926870748299319,0.031606108727482,-0.186871270247229,0.286516853932584,0.547368421052632,-0.86326194398682,"Stabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.178,-0.993,"9:9","21/150","V:M",14.1489809714062,0.890414731995374,102.692976014008,0.137779442378573,507.712885368923,NA,1.98848253379833,2.1018584548314e-08,7.67739653395739,10.9022485555592,Inf,5.92457926729285e-11,"lineage2","dr_mutations_pyrazinamide","THR",0,"MDR_4152","SRR6824577","lineage2.2.1","cn","China: Pingding County, Yangquan City, Shanxi Province","pnca_p.met1thr","A","-","MET","MA1","pnca_complex.pdb"
|
|
"M1T","L2","PZA","M","M1",1,"T",1,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",23.978,0.344,0.109,0.867771,-1.096,0.51,52,75,-1.048,9,9,88,0.392857142857143,"loop",0.633333333333333,4.12,0.0007187005893344,97.3828619670747,1395803.74890195,Inf,42.8452490786805,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,2,0,0,2,0,0,0,0,0.154260089686099,0.0926870748299319,0.031606108727482,-0.186871270247229,0.286516853932584,0.547368421052632,-0.86326194398682,"Stabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.178,-0.993,"9:9","21/150","V:M",14.1489809714062,0.890414731995374,102.692976014008,0.137779442378573,507.712885368923,NA,1.98848253379833,2.1018584548314e-08,7.67739653395739,10.9022485555592,Inf,5.92457926729285e-11,"lineage2","dr_mutations_pyrazinamide","THR",0,"MDR_4129","SRR6824467","lineage2.2.1","cn","China: Pingding County, Yangquan City, Shanxi Province","pnca_p.met1thr","A","-","MET","MA1","pnca_complex.pdb"
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|
"M1T","L2","PZA","M","M1",1,"T",NA,"XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",23.978,0.344,0.109,0.867771,-1.096,0.51,52,75,-1.048,9,9,88,0.392857142857143,"loop",0.633333333333333,4.12,0.0007187005893344,97.3828619670747,1395803.74890195,Inf,42.8452490786805,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,2,0,0,2,0,0,0,0,0.154260089686099,0.0926870748299319,0.031606108727482,-0.186871270247229,0.286516853932584,0.547368421052632,-0.86326194398682,"Stabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.178,-0.993,"9:9","21/150","V:M",14.1489809714062,0.890414731995374,102.692976014008,0.137779442378573,507.712885368923,NA,1.98848253379833,2.1018584548314e-08,7.67739653395739,10.9022485555592,Inf,5.92457926729285e-11,"lineage2","dr_mutations_pyrazinamide","THR",0,"SAMN02419548","SRR1183962_SRR1180936_SRR1159760_SRR1159954","lineage2.2.1","by","Belarus","pnca_p.met1thr","A","-","MET","MA1","pnca_complex.pdb"
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|
"M1T","L4","PZA","M","M1",1,"T",NA,"XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",23.978,0.344,0.109,0.867771,-1.096,0.51,52,75,-1.048,9,9,88,0.392857142857143,"loop",0.633333333333333,4.12,0.0007187005893344,97.3828619670747,1395803.74890195,Inf,42.8452490786805,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,2,0,0,2,0,0,0,0,0.154260089686099,0.0926870748299319,0.031606108727482,-0.186871270247229,0.286516853932584,0.547368421052632,-0.86326194398682,"Stabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.178,-0.993,"9:9","21/150","V:M",14.1489809714062,0.890414731995374,102.692976014008,0.137779442378573,507.712885368923,NA,1.98848253379833,2.1018584548314e-08,7.67739653395739,10.9022485555592,Inf,5.92457926729285e-11,"lineage4","dr_mutations_pyrazinamide","THR",0,"ERR1034850","ERR1034850","lineage4.3.4.2","pt","Portugal","pnca_p.met1thr","A","-","MET","MA1","pnca_complex.pdb"
|
|
"M1T","L4","PZA","M","M1",1,"T",NA,"XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",23.978,0.344,0.109,0.867771,-1.096,0.51,52,75,-1.048,9,9,88,0.392857142857143,"loop",0.633333333333333,4.12,0.0007187005893344,97.3828619670747,1395803.74890195,Inf,42.8452490786805,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,2,0,0,2,0,0,0,0,0.154260089686099,0.0926870748299319,0.031606108727482,-0.186871270247229,0.286516853932584,0.547368421052632,-0.86326194398682,"Stabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.178,-0.993,"9:9","21/150","V:M",14.1489809714062,0.890414731995374,102.692976014008,0.137779442378573,507.712885368923,NA,1.98848253379833,2.1018584548314e-08,7.67739653395739,10.9022485555592,Inf,5.92457926729285e-11,"lineage4","dr_mutations_pyrazinamide","THR",0,"ERR275203","ERR275203","lineage4.3.4.2","pt","Portugal","pnca_p.met1thr","A","-","MET","MA1","pnca_complex.pdb"
|
|
"M1T","L4","PZA","M","M1",1,"T",NA,"XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",23.978,0.344,0.109,0.867771,-1.096,0.51,52,75,-1.048,9,9,88,0.392857142857143,"loop",0.633333333333333,4.12,0.0007187005893344,97.3828619670747,1395803.74890195,Inf,42.8452490786805,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,2,0,0,2,0,0,0,0,0.154260089686099,0.0926870748299319,0.031606108727482,-0.186871270247229,0.286516853932584,0.547368421052632,-0.86326194398682,"Stabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.178,-0.993,"9:9","21/150","V:M",14.1489809714062,0.890414731995374,102.692976014008,0.137779442378573,507.712885368923,NA,1.98848253379833,2.1018584548314e-08,7.67739653395739,10.9022485555592,Inf,5.92457926729285e-11,"lineage4","dr_mutations_pyrazinamide","THR",0,"ERR1034847","ERR1034847","lineage4.3.4.2","pt","Portugal","pnca_p.met1thr","A","-","MET","MA1","pnca_complex.pdb"
|
|
"M1T","L2","PZA","M","M1",1,"T",1,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",23.978,0.344,0.109,0.867771,-1.096,0.51,52,75,-1.048,9,9,88,0.392857142857143,"loop",0.633333333333333,4.12,0.0007187005893344,97.3828619670747,1395803.74890195,Inf,42.8452490786805,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,2,0,0,2,0,0,0,0,0.154260089686099,0.0926870748299319,0.031606108727482,-0.186871270247229,0.286516853932584,0.547368421052632,-0.86326194398682,"Stabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.178,-0.993,"9:9","21/150","V:M",14.1489809714062,0.890414731995374,102.692976014008,0.137779442378573,507.712885368923,NA,1.98848253379833,2.1018584548314e-08,7.67739653395739,10.9022485555592,Inf,5.92457926729285e-11,"lineage2","dr_mutations_pyrazinamide","THR",0,"MDR_4113","SRR6824464","lineage2.2.1","cn","China: Pingding County, Yangquan City, Shanxi Province","pnca_p.met1thr","A","-","MET","MA1","pnca_complex.pdb"
|
|
"M1T","L4","PZA","M","M1",1,"T",1,"XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",23.978,0.344,0.109,0.867771,-1.096,0.51,52,75,-1.048,9,9,88,0.392857142857143,"loop",0.633333333333333,4.12,0.0007187005893344,97.3828619670747,1395803.74890195,Inf,42.8452490786805,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,2,0,0,2,0,0,0,0,0.154260089686099,0.0926870748299319,0.031606108727482,-0.186871270247229,0.286516853932584,0.547368421052632,-0.86326194398682,"Stabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.178,-0.993,"9:9","21/150","V:M",14.1489809714062,0.890414731995374,102.692976014008,0.137779442378573,507.712885368923,NA,1.98848253379833,2.1018584548314e-08,7.67739653395739,10.9022485555592,Inf,5.92457926729285e-11,"lineage4","dr_mutations_pyrazinamide","THR",0,"ERR1034908","ERR1034908","lineage4.3.4.2","pt","Portugal","pnca_p.met1thr","A","-","MET","MA1","pnca_complex.pdb"
|
|
"M1T","L4","PZA","M","M1",1,"T",1,"XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",23.978,0.344,0.109,0.867771,-1.096,0.51,52,75,-1.048,9,9,88,0.392857142857143,"loop",0.633333333333333,4.12,0.0007187005893344,97.3828619670747,1395803.74890195,Inf,42.8452490786805,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,2,0,0,2,0,0,0,0,0.154260089686099,0.0926870748299319,0.031606108727482,-0.186871270247229,0.286516853932584,0.547368421052632,-0.86326194398682,"Stabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.178,-0.993,"9:9","21/150","V:M",14.1489809714062,0.890414731995374,102.692976014008,0.137779442378573,507.712885368923,NA,1.98848253379833,2.1018584548314e-08,7.67739653395739,10.9022485555592,Inf,5.92457926729285e-11,"lineage4","dr_mutations_pyrazinamide","THR",0,"ERR2864241","ERR2864241","lineage4.3.4.2","pt","Portugal","pnca_p.met1thr","A","-","MET","MA1","pnca_complex.pdb"
|
|
"M1T","L4","PZA","M","M1",1,"T",1,"XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",23.978,0.344,0.109,0.867771,-1.096,0.51,52,75,-1.048,9,9,88,0.392857142857143,"loop",0.633333333333333,4.12,0.0007187005893344,97.3828619670747,1395803.74890195,Inf,42.8452490786805,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,2,0,0,2,0,0,0,0,0.154260089686099,0.0926870748299319,0.031606108727482,-0.186871270247229,0.286516853932584,0.547368421052632,-0.86326194398682,"Stabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.178,-0.993,"9:9","21/150","V:M",14.1489809714062,0.890414731995374,102.692976014008,0.137779442378573,507.712885368923,NA,1.98848253379833,2.1018584548314e-08,7.67739653395739,10.9022485555592,Inf,5.92457926729285e-11,"lineage4","dr_mutations_pyrazinamide","THR",0,"ERR1035222","ERR1035222","lineage4.3.4.2","pt","Portugal","pnca_p.met1thr","A","-","MET","MA1","pnca_complex.pdb"
|
|
"M1T","L1","PZA","M","M1",1,"T",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",23.978,0.344,0.109,0.867771,-1.096,0.51,52,75,-1.048,9,9,88,0.392857142857143,"loop",0.633333333333333,4.12,0.0007187005893344,97.3828619670747,1395803.74890195,Inf,42.8452490786805,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,2,0,0,2,0,0,0,0,0.154260089686099,0.0926870748299319,0.031606108727482,-0.186871270247229,0.286516853932584,0.547368421052632,-0.86326194398682,"Stabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.178,-0.993,"9:9","21/150","V:M",14.1489809714062,0.890414731995374,102.692976014008,0.137779442378573,507.712885368923,NA,1.98848253379833,2.1018584548314e-08,7.67739653395739,10.9022485555592,Inf,5.92457926729285e-11,"lineage1","dr_mutations_pyrazinamide","THR",0,"SRR5818699","SRR5818699","lineage1.1.2","dj","Djibouti","pnca_p.met1thr","A","-","MET","MA1","pnca_complex.pdb"
|
|
"M1T","L2","PZA","M","M1",1,"T",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",23.978,0.344,0.109,0.867771,-1.096,0.51,52,75,-1.048,9,9,88,0.392857142857143,"loop",0.633333333333333,4.12,0.0007187005893344,97.3828619670747,1395803.74890195,Inf,42.8452490786805,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,2,0,0,2,0,0,0,0,0.154260089686099,0.0926870748299319,0.031606108727482,-0.186871270247229,0.286516853932584,0.547368421052632,-0.86326194398682,"Stabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.178,-0.993,"9:9","21/150","V:M",14.1489809714062,0.890414731995374,102.692976014008,0.137779442378573,507.712885368923,NA,1.98848253379833,2.1018584548314e-08,7.67739653395739,10.9022485555592,Inf,5.92457926729285e-11,"lineage2","dr_mutations_pyrazinamide","THR",0,"SRS797056","SRR1723559","lineage2.2.1","cn","China:Shanxi","pnca_p.met1thr","A","-","MET","MA1","pnca_complex.pdb"
|
|
"M1T","L4","PZA","M","M1",1,"T",1,"XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",23.978,0.344,0.109,0.867771,-1.096,0.51,52,75,-1.048,9,9,88,0.392857142857143,"loop",0.633333333333333,4.12,0.0007187005893344,97.3828619670747,1395803.74890195,Inf,42.8452490786805,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,2,0,0,2,0,0,0,0,0.154260089686099,0.0926870748299319,0.031606108727482,-0.186871270247229,0.286516853932584,0.547368421052632,-0.86326194398682,"Stabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.178,-0.993,"9:9","21/150","V:M",14.1489809714062,0.890414731995374,102.692976014008,0.137779442378573,507.712885368923,NA,1.98848253379833,2.1018584548314e-08,7.67739653395739,10.9022485555592,Inf,5.92457926729285e-11,"lineage4","dr_mutations_pyrazinamide","THR",0,"ERR1035226","ERR1035226","lineage4.3.4.2","pt","Portugal","pnca_p.met1thr","A","-","MET","MA1","pnca_complex.pdb"
|
|
"M1T","L2","PZA","M","M1",1,"T",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",23.978,0.344,0.109,0.867771,-1.096,0.51,52,75,-1.048,9,9,88,0.392857142857143,"loop",0.633333333333333,4.12,0.0007187005893344,97.3828619670747,1395803.74890195,Inf,42.8452490786805,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,2,0,0,2,0,0,0,0,0.154260089686099,0.0926870748299319,0.031606108727482,-0.186871270247229,0.286516853932584,0.547368421052632,-0.86326194398682,"Stabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.178,-0.993,"9:9","21/150","V:M",14.1489809714062,0.890414731995374,102.692976014008,0.137779442378573,507.712885368923,NA,1.98848253379833,2.1018584548314e-08,7.67739653395739,10.9022485555592,Inf,5.92457926729285e-11,"lineage2","dr_mutations_pyrazinamide","THR",0,"SRR5709907,SAMN07236409","SRR5709907","lineage2.2.1","th","Thailand","pnca_p.met1thr","A","-","MET","MA1","pnca_complex.pdb"
|
|
"M1T","L2","PZA","M","M1",1,"T",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",23.978,0.344,0.109,0.867771,-1.096,0.51,52,75,-1.048,9,9,88,0.392857142857143,"loop",0.633333333333333,4.12,0.0007187005893344,97.3828619670747,1395803.74890195,Inf,42.8452490786805,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,2,0,0,2,0,0,0,0,0.154260089686099,0.0926870748299319,0.031606108727482,-0.186871270247229,0.286516853932584,0.547368421052632,-0.86326194398682,"Stabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.178,-0.993,"9:9","21/150","V:M",14.1489809714062,0.890414731995374,102.692976014008,0.137779442378573,507.712885368923,NA,1.98848253379833,2.1018584548314e-08,7.67739653395739,10.9022485555592,Inf,5.92457926729285e-11,"lineage2","dr_mutations_pyrazinamide","THR",0,"SRS797053","SRR1723556","lineage2.2.1","cn","China:Shanxi","pnca_p.met1thr","A","-","MET","MA1","pnca_complex.pdb"
|
|
"M1T","L3","PZA","M","M1",1,"T",1,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",23.978,0.344,0.109,0.867771,-1.096,0.51,52,75,-1.048,9,9,88,0.392857142857143,"loop",0.633333333333333,4.12,0.0007187005893344,97.3828619670747,1395803.74890195,Inf,42.8452490786805,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,2,0,0,2,0,0,0,0,0.154260089686099,0.0926870748299319,0.031606108727482,-0.186871270247229,0.286516853932584,0.547368421052632,-0.86326194398682,"Stabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.178,-0.993,"9:9","21/150","V:M",14.1489809714062,0.890414731995374,102.692976014008,0.137779442378573,507.712885368923,NA,1.98848253379833,2.1018584548314e-08,7.67739653395739,10.9022485555592,Inf,5.92457926729285e-11,"lineage3","dr_mutations_pyrazinamide","THR",0,"ERR2510282","ERR2510282","lineage3","pk","Pakistan","pnca_p.met1thr","A","-","MET","MA1","pnca_complex.pdb"
|
|
"M1T","L2","PZA","M","M1",1,"T",NA,"XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",23.978,0.344,0.109,0.867771,-1.096,0.51,52,75,-1.048,9,9,88,0.392857142857143,"loop",0.633333333333333,4.12,0.0007187005893344,97.3828619670747,1395803.74890195,Inf,42.8452490786805,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,2,0,0,2,0,0,0,0,0.154260089686099,0.0926870748299319,0.031606108727482,-0.186871270247229,0.286516853932584,0.547368421052632,-0.86326194398682,"Stabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.178,-0.993,"9:9","21/150","V:M",14.1489809714062,0.890414731995374,102.692976014008,0.137779442378573,507.712885368923,NA,1.98848253379833,2.1018584548314e-08,7.67739653395739,10.9022485555592,Inf,5.92457926729285e-11,"lineage2","dr_mutations_pyrazinamide","THR",0,"SAMN02419662","SRR1172219_SRR1169121_SRR1163325_SRR1163145","lineage2.2.1","by","Belarus","pnca_p.met1thr","A","-","MET","MA1","pnca_complex.pdb"
|
|
"M1T","L2","PZA","M","M1",1,"T",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",23.978,0.344,0.109,0.867771,-1.096,0.51,52,75,-1.048,9,9,88,0.392857142857143,"loop",0.633333333333333,4.12,0.0007187005893344,97.3828619670747,1395803.74890195,Inf,42.8452490786805,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,2,0,0,2,0,0,0,0,0.154260089686099,0.0926870748299319,0.031606108727482,-0.186871270247229,0.286516853932584,0.547368421052632,-0.86326194398682,"Stabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.178,-0.993,"9:9","21/150","V:M",14.1489809714062,0.890414731995374,102.692976014008,0.137779442378573,507.712885368923,NA,1.98848253379833,2.1018584548314e-08,7.67739653395739,10.9022485555592,Inf,5.92457926729285e-11,"lineage2","dr_mutations_pyrazinamide","THR",0,"ETB0073","SRR6257010","lineage2.2.1","ru","Russia:Tatarstan","pnca_p.met1thr","A","-","MET","MA1","pnca_complex.pdb"
|
|
"M1T","L4","PZA","M","M1",1,"T",NA,"XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",23.978,0.344,0.109,0.867771,-1.096,0.51,52,75,-1.048,9,9,88,0.392857142857143,"loop",0.633333333333333,4.12,0.0007187005893344,97.3828619670747,1395803.74890195,Inf,42.8452490786805,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,2,0,0,2,0,0,0,0,0.154260089686099,0.0926870748299319,0.031606108727482,-0.186871270247229,0.286516853932584,0.547368421052632,-0.86326194398682,"Stabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.178,-0.993,"9:9","21/150","V:M",14.1489809714062,0.890414731995374,102.692976014008,0.137779442378573,507.712885368923,NA,1.98848253379833,2.1018584548314e-08,7.67739653395739,10.9022485555592,Inf,5.92457926729285e-11,"lineage4","dr_mutations_pyrazinamide","THR",0,"ERR1034885","ERR1034885","lineage4.3.4.2","pt","Portugal","pnca_p.met1thr","A","-","MET","MA1","pnca_complex.pdb"
|
|
"M1T","L2","PZA","M","M1",1,"T",1,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",23.978,0.344,0.109,0.867771,-1.096,0.51,52,75,-1.048,9,9,88,0.392857142857143,"loop",0.633333333333333,4.12,0.0007187005893344,97.3828619670747,1395803.74890195,Inf,42.8452490786805,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,2,0,0,2,0,0,0,0,0.154260089686099,0.0926870748299319,0.031606108727482,-0.186871270247229,0.286516853932584,0.547368421052632,-0.86326194398682,"Stabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.178,-0.993,"9:9","21/150","V:M",14.1489809714062,0.890414731995374,102.692976014008,0.137779442378573,507.712885368923,NA,1.98848253379833,2.1018584548314e-08,7.67739653395739,10.9022485555592,Inf,5.92457926729285e-11,"lineage2","dr_mutations_pyrazinamide","THR",0,"ERR2510666","ERR2510666","lineage2.2.1","it","Italy","pnca_p.met1thr","A","-","MET","MA1","pnca_complex.pdb"
|
|
"M1T","L4","PZA","M","M1",1,"T",1,"XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",23.978,0.344,0.109,0.867771,-1.096,0.51,52,75,-1.048,9,9,88,0.392857142857143,"loop",0.633333333333333,4.12,0.0007187005893344,97.3828619670747,1395803.74890195,Inf,42.8452490786805,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,2,0,0,2,0,0,0,0,0.154260089686099,0.0926870748299319,0.031606108727482,-0.186871270247229,0.286516853932584,0.547368421052632,-0.86326194398682,"Stabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.178,-0.993,"9:9","21/150","V:M",14.1489809714062,0.890414731995374,102.692976014008,0.137779442378573,507.712885368923,NA,1.98848253379833,2.1018584548314e-08,7.67739653395739,10.9022485555592,Inf,5.92457926729285e-11,"lineage4","dr_mutations_pyrazinamide","THR",0,"ERR1035215","ERR1035215","lineage4.3.4.2","pt","Portugal","pnca_p.met1thr","A","-","MET","MA1","pnca_complex.pdb"
|
|
"M1T","L2","PZA","M","M1",1,"T",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",23.978,0.344,0.109,0.867771,-1.096,0.51,52,75,-1.048,9,9,88,0.392857142857143,"loop",0.633333333333333,4.12,0.0007187005893344,97.3828619670747,1395803.74890195,Inf,42.8452490786805,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,2,0,0,2,0,0,0,0,0.154260089686099,0.0926870748299319,0.031606108727482,-0.186871270247229,0.286516853932584,0.547368421052632,-0.86326194398682,"Stabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.178,-0.993,"9:9","21/150","V:M",14.1489809714062,0.890414731995374,102.692976014008,0.137779442378573,507.712885368923,NA,1.98848253379833,2.1018584548314e-08,7.67739653395739,10.9022485555592,Inf,5.92457926729285e-11,"lineage2","dr_mutations_pyrazinamide","THR",0,"SRR5710022,SAMN07236279","SRR5710022","lineage2.1","th","Thailand","pnca_p.met1thr","A","-","MET","MA1","pnca_complex.pdb"
|
|
"M1T","L2","PZA","M","M1",1,"T",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",23.978,0.344,0.109,0.867771,-1.096,0.51,52,75,-1.048,9,9,88,0.392857142857143,"loop",0.633333333333333,4.12,0.0007187005893344,97.3828619670747,1395803.74890195,Inf,42.8452490786805,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,2,0,0,2,0,0,0,0,0.154260089686099,0.0926870748299319,0.031606108727482,-0.186871270247229,0.286516853932584,0.547368421052632,-0.86326194398682,"Stabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.178,-0.993,"9:9","21/150","V:M",14.1489809714062,0.890414731995374,102.692976014008,0.137779442378573,507.712885368923,NA,1.98848253379833,2.1018584548314e-08,7.67739653395739,10.9022485555592,Inf,5.92457926729285e-11,"lineage2","dr_mutations_pyrazinamide","THR",0,"SRS797054","SRR1723557","lineage2.2.1","cn","China:Shanxi","pnca_p.met1thr","A","-","MET","MA1","pnca_complex.pdb"
|
|
"M1T","L2","PZA","M","M1",1,"T",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",23.978,0.344,0.109,0.867771,-1.096,0.51,52,75,-1.048,9,9,88,0.392857142857143,"loop",0.633333333333333,4.12,0.0007187005893344,97.3828619670747,1395803.74890195,Inf,42.8452490786805,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,2,0,0,2,0,0,0,0,0.154260089686099,0.0926870748299319,0.031606108727482,-0.186871270247229,0.286516853932584,0.547368421052632,-0.86326194398682,"Stabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.178,-0.993,"9:9","21/150","V:M",14.1489809714062,0.890414731995374,102.692976014008,0.137779442378573,507.712885368923,NA,1.98848253379833,2.1018584548314e-08,7.67739653395739,10.9022485555592,Inf,5.92457926729285e-11,"lineage2","dr_mutations_pyrazinamide","THR",0,"SRS797055","SRR1723558","lineage2.2.1","cn","China:Shanxi","pnca_p.met1thr","A","-","MET","MA1","pnca_complex.pdb"
|
|
"M1T","L4","PZA","M","M1",1,"T",NA,"XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",23.978,0.344,0.109,0.867771,-1.096,0.51,52,75,-1.048,9,9,88,0.392857142857143,"loop",0.633333333333333,4.12,0.0007187005893344,97.3828619670747,1395803.74890195,Inf,42.8452490786805,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,2,0,0,2,0,0,0,0,0.154260089686099,0.0926870748299319,0.031606108727482,-0.186871270247229,0.286516853932584,0.547368421052632,-0.86326194398682,"Stabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.178,-0.993,"9:9","21/150","V:M",14.1489809714062,0.890414731995374,102.692976014008,0.137779442378573,507.712885368923,NA,1.98848253379833,2.1018584548314e-08,7.67739653395739,10.9022485555592,Inf,5.92457926729285e-11,"lineage4","dr_mutations_pyrazinamide","THR",0,"ERR275230","ERR275230","lineage4.3.4.2","pt","Portugal","pnca_p.met1thr","A","-","MET","MA1","pnca_complex.pdb"
|
|
"R2L","L4","PZA","R","R2",2,"L",0,"Pre-XDR","OM","hydrophilic","hydrophobic","basic","non-polar","pos","non-polar",21.092,-2.083,0.062,1.78755,-0.708,-0.24,44,71,-0.015,5,5,55,0.200729927007299,"strand",-0.266666666666667,4.74,7.18700589334483e-05,2.42412778478352,0.0001249735077034,0,1.03410070803344e-29,38,30,0,4,26,0,0,0,0,4,0,2,2,0,0,0,0,1,0,-2,2,0,0,0,-2,-0.527608915906788,0.0527210884353741,0.0651064620225963,-0.120716112531969,-0.06282722513089,0.463157894736842,-0.0123558484349259,"Destabilising","Stabilising","Destabilising","Destabilising","Destabilising","effect",-0.244,0.083,"6:5","84/150","R:K:N:H:T:S:E",-8.9874087814964,0.940032862253633,119.46804443549,-0.0752285585987755,NA,4692673.51081259,0.384555509373631,1,0,0,188.544222231268,0.999999999999997,"lineage4","other_mutations_pyrazinamide","LEU",0,"ERR2516706","ERR2516706","lineage4","pe","Peru","pnca_p.arg2leu","A","E","ARG","RA2","pnca_complex.pdb"
|
|
"R2P","L4","PZA","R","R2",2,"P",NA,"MDR","OM","hydrophilic","hydrophilic","basic","non-polar","pos","non-polar",21.092,-2.244,-1.031,4.20376,-1.935,-0.43,63,80,-0.015,5,5,55,0.200729927007299,"strand",-0.266666666666667,4.74,NA,NA,NA,NA,NA,48,28,0,4,24,0,0,0,0,2,0,4,0,0,0,0,0,4,2,1,1,4,0,6,0,-0.56838905775076,-0.26640826873385,0.153110089671399,-0.329923273657289,-0.112565445026178,0.663157894736842,-0.0123558484349259,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.244,0.083,"6:5","84/150","R:K:N:H:T:S:E",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage4","other_mutations_pyrazinamide","PRO",0,"ERR779907","ERR779907","lineage4.3.3","pe","","pnca_p.arg2pro","A","E","ARG","RA2","pnca_complex.pdb"
|
|
"R2W","L4","PZA","R","R2",2,"W",NA,"Pre-XDR","OM","hydrophilic","hydrophobic","basic","non-polar","pos","non-polar",21.092,-1.147,-0.164,4.38565,-0.74,-0.16,58,75,-0.015,5,5,55,0.200729927007299,"strand",-0.266666666666667,4.74,NA,NA,NA,NA,NA,8,30,0,4,26,0,0,0,0,4,0,2,2,0,0,0,0,0,0,-5,5,6,0,6,4,-0.290526849037487,-0.0423772609819121,0.159734919397723,-0.12617220801364,-0.0418848167539267,0.610526315789474,-0.0123558484349259,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.244,0.083,"6:5","84/150","R:K:N:H:T:S:E",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage4","other_mutations_pyrazinamide","TRP",0,"SAMN02584674","SRR1168960_SRR1166135","lineage4.2.1","md","Moldova","pnca_p.arg2trp","A","E","ARG","RA2","pnca_complex.pdb"
|
|
"A3E","L2","PZA","A","A3",3,"E",1,"MDR","DM","hydrophobic","hydrophilic","non-polar","acidic","non-polar","neg",18.028,-1.552,-2.829,2.75936,-5.34,-1.11,56,75,-0.873,8,8,0,0,"strand",0.366666666666667,8.38,0.0002874802357337,38.8547368421053,1392277.50785087,Inf,13.9909822352959,-30,-38,0,-2,-36,0,0,0,0,0,0,0,0,0,0,0,0,-13,0,-3,-14,-4,0,-2,-9,-0.393110435663627,-0.731007751937984,0.100501897595408,-0.910485933503836,-0.290575916230366,0.589473684210526,-0.719110378912685,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","141/150","A:G:T:V:C",14.1464514590954,0.930573112990226,162.371849599086,0.0871237932808215,0.011399544335555,NA,1.58944397188817,0.0008528275207519,3.06913879340442,3.20302487654751,Inf,0.0001836895199759,"lineage2","dr_mutations_pyrazinamide","GLU",0,"MDR_17174","SRR6824459","lineage2.2.1","cn","China: Ma City, Huanggang City,Hubei Province","pnca_p.ala3glu","A","E","ALA","AA3","pnca_complex.pdb"
|
|
"A3E","L2","PZA","A","A3",3,"E",NA,"MDR","DM","hydrophobic","hydrophilic","non-polar","acidic","non-polar","neg",18.028,-1.552,-2.829,2.75936,-5.34,-1.11,56,75,-0.873,8,8,0,0,"strand",0.366666666666667,8.38,0.0002874802357337,38.8547368421053,1392277.50785087,Inf,13.9909822352959,-30,-38,0,-2,-36,0,0,0,0,0,0,0,0,0,0,0,0,-13,0,-3,-14,-4,0,-2,-9,-0.393110435663627,-0.731007751937984,0.100501897595408,-0.910485933503836,-0.290575916230366,0.589473684210526,-0.719110378912685,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","141/150","A:G:T:V:C",14.1464514590954,0.930573112990226,162.371849599086,0.0871237932808215,0.011399544335555,NA,1.58944397188817,0.0008528275207519,3.06913879340442,3.20302487654751,Inf,0.0001836895199759,"lineage2","dr_mutations_pyrazinamide","GLU",0,"SRS797278","SRR1723804","lineage2.2.1","cn","China:Hubei","pnca_p.ala3glu","A","E","ALA","AA3","pnca_complex.pdb"
|
|
"A3E","L6","PZA","A","A3",3,"E",NA,"MDR","DM","hydrophobic","hydrophilic","non-polar","acidic","non-polar","neg",18.028,-1.552,-2.829,2.75936,-5.34,-1.11,56,75,-0.873,8,8,0,0,"strand",0.366666666666667,8.38,0.0002874802357337,38.8547368421053,1392277.50785087,Inf,13.9909822352959,-30,-38,0,-2,-36,0,0,0,0,0,0,0,0,0,0,0,0,-13,0,-3,-14,-4,0,-2,-9,-0.393110435663627,-0.731007751937984,0.100501897595408,-0.910485933503836,-0.290575916230366,0.589473684210526,-0.719110378912685,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","141/150","A:G:T:V:C",14.1464514590954,0.930573112990226,162.371849599086,0.0871237932808215,0.011399544335555,NA,1.58944397188817,0.0008528275207519,3.06913879340442,3.20302487654751,Inf,0.0001836895199759,"lineage6","dr_mutations_pyrazinamide","GLU",0,"ERR1215461","ERR1215461","lineage6","gh","Ghana","pnca_p.ala3glu","A","E","ALA","AA3","pnca_complex.pdb"
|
|
"A3E","L2","PZA","A","A3",3,"E",1,"MDR","DM","hydrophobic","hydrophilic","non-polar","acidic","non-polar","neg",18.028,-1.552,-2.829,2.75936,-5.34,-1.11,56,75,-0.873,8,8,0,0,"strand",0.366666666666667,8.38,0.0002874802357337,38.8547368421053,1392277.50785087,Inf,13.9909822352959,-30,-38,0,-2,-36,0,0,0,0,0,0,0,0,0,0,0,0,-13,0,-3,-14,-4,0,-2,-9,-0.393110435663627,-0.731007751937984,0.100501897595408,-0.910485933503836,-0.290575916230366,0.589473684210526,-0.719110378912685,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","141/150","A:G:T:V:C",14.1464514590954,0.930573112990226,162.371849599086,0.0871237932808215,0.011399544335555,NA,1.58944397188817,0.0008528275207519,3.06913879340442,3.20302487654751,Inf,0.0001836895199759,"lineage2","dr_mutations_pyrazinamide","GLU",0,"MDR_17238","SRR6824452","lineage2.2.1","cn","China: Ma City, Huanggang City,Hubei Province","pnca_p.ala3glu","A","E","ALA","AA3","pnca_complex.pdb"
|
|
"A3E","L2","PZA","A","A3",3,"E",1,"XDR","DM","hydrophobic","hydrophilic","non-polar","acidic","non-polar","neg",18.028,-1.552,-2.829,2.75936,-5.34,-1.11,56,75,-0.873,8,8,0,0,"strand",0.366666666666667,8.38,0.0002874802357337,38.8547368421053,1392277.50785087,Inf,13.9909822352959,-30,-38,0,-2,-36,0,0,0,0,0,0,0,0,0,0,0,0,-13,0,-3,-14,-4,0,-2,-9,-0.393110435663627,-0.731007751937984,0.100501897595408,-0.910485933503836,-0.290575916230366,0.589473684210526,-0.719110378912685,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","141/150","A:G:T:V:C",14.1464514590954,0.930573112990226,162.371849599086,0.0871237932808215,0.011399544335555,NA,1.58944397188817,0.0008528275207519,3.06913879340442,3.20302487654751,Inf,0.0001836895199759,"lineage2","dr_mutations_pyrazinamide","GLU",0,"ERR067750,0450Q-sc-2011-08-25T12:38:41Z-1262349","ERR067750","lineage2.2.1","ru","Russia,Samara","pnca_p.ala3glu","A","E","ALA","AA3","pnca_complex.pdb"
|
|
"A3E","L2","PZA","A","A3",3,"E",1,"Pre-XDR","DM","hydrophobic","hydrophilic","non-polar","acidic","non-polar","neg",18.028,-1.552,-2.829,2.75936,-5.34,-1.11,56,75,-0.873,8,8,0,0,"strand",0.366666666666667,8.38,0.0002874802357337,38.8547368421053,1392277.50785087,Inf,13.9909822352959,-30,-38,0,-2,-36,0,0,0,0,0,0,0,0,0,0,0,0,-13,0,-3,-14,-4,0,-2,-9,-0.393110435663627,-0.731007751937984,0.100501897595408,-0.910485933503836,-0.290575916230366,0.589473684210526,-0.719110378912685,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","141/150","A:G:T:V:C",14.1464514590954,0.930573112990226,162.371849599086,0.0871237932808215,0.011399544335555,NA,1.58944397188817,0.0008528275207519,3.06913879340442,3.20302487654751,Inf,0.0001836895199759,"lineage2","dr_mutations_pyrazinamide","GLU",0,"ETB0012","SRR6256984","lineage2.2.1","ru","Russia:Arkhangelsk","pnca_p.ala3glu","A","E","ALA","AA3","pnca_complex.pdb"
|
|
"A3P","L4","PZA","A","A3",3,"P",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",18.028,-2.664,-1.124,-0.155697,-3.837,-0.13,66,80,-0.873,8,8,0,0,"strand",0.366666666666667,8.38,7.18700589334483e-05,9.70142977291842,188179.926264599,Inf,0.763784339928386,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,2,-7,-4,-2,0,-2,-1,-0.674772036474164,-0.290439276485788,-0.0299348227332154,-0.654219948849105,-0.0340314136125654,0.694736842105263,-0.719110378912685,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","141/150","A:G:T:V:C",12.1451538387263,0.919026337424228,119.468044436222,0.101660271548263,5.01153666063644e-06,NA,0.986835744238421,0.170978870202674,0.767057556984365,0.124324963210678,Inf,0.382146811758261,"lineage4","dr_mutations_pyrazinamide","PRO",0,"3200","ERR2432999","lineage4.1.2.1","br","Brazil","pnca_p.ala3pro","A","E","ALA","AA3","pnca_complex.pdb"
|
|
"A3P","L4","PZA","A","A3",3,"P",NA,"MDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",18.028,-2.664,-1.124,-0.155697,-3.837,-0.13,66,80,-0.873,8,8,0,0,"strand",0.366666666666667,8.38,7.18700589334483e-05,9.70142977291842,188179.926264599,Inf,0.763784339928386,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,2,-7,-4,-2,0,-2,-1,-0.674772036474164,-0.290439276485788,-0.0299348227332154,-0.654219948849105,-0.0340314136125654,0.694736842105263,-0.719110378912685,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","141/150","A:G:T:V:C",12.1451538387263,0.919026337424228,119.468044436222,0.101660271548263,5.01153666063644e-06,NA,0.986835744238421,0.170978870202674,0.767057556984365,0.124324963210678,Inf,0.382146811758261,"lineage4","dr_mutations_pyrazinamide","PRO",0,"1662","ERR2432989","lineage4.1.2.1","br","Brazil","pnca_p.ala3pro","A","E","ALA","AA3","pnca_complex.pdb"
|
|
"A3P","L4","PZA","A","A3",3,"P",1,"MDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",18.028,-2.664,-1.124,-0.155697,-3.837,-0.13,66,80,-0.873,8,8,0,0,"strand",0.366666666666667,8.38,7.18700589334483e-05,9.70142977291842,188179.926264599,Inf,0.763784339928386,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,2,-7,-4,-2,0,-2,-1,-0.674772036474164,-0.290439276485788,-0.0299348227332154,-0.654219948849105,-0.0340314136125654,0.694736842105263,-0.719110378912685,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","141/150","A:G:T:V:C",12.1451538387263,0.919026337424228,119.468044436222,0.101660271548263,5.01153666063644e-06,NA,0.986835744238421,0.170978870202674,0.767057556984365,0.124324963210678,Inf,0.382146811758261,"lineage4","dr_mutations_pyrazinamide","PRO",0,"10982","ERR3014600","lineage4.1.2.1","tn","Tunisia:Tunis","pnca_p.ala3pro","A","E","ALA","AA3","pnca_complex.pdb"
|
|
"L4S","L2","PZA","L","L4",4,"S",1,"MDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",15.328,-1.078,-3.87,5.57838,-2.638,-3.7,63,80,-1.075,9,9,0,0,"strand",3.36666666666667,8.8,0.0024435820037372,28.4570212765957,28.4570177059942,28.4308865607855,107.057952768928,22,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,-3,0,-1,-2,6,0,4,6,-0.273049645390071,-1,0.203176742254824,-0.449786871270247,-0.968586387434555,0.663157894736842,-0.885502471169687,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.152,-1.028,"9:9","146/150","F:V:L:I",3.34839479820379,4.89069202996555e-12,0.484662577645081,6.90871330415739,12.0071584873314,83.7151686983107,1.4541894385859,5.6263316435115e-18,17.2497746719749,10.8739157094292,94.2522723934353,4.32340113554558e-25,"lineage2","dr_mutations_pyrazinamide","SER",0,"ERR2516880","ERR2516880","lineage2.2.1","gb","UK","pnca_p.leu4ser","A","E","LEU","LA4","pnca_complex.pdb"
|
|
"L4S","L3","PZA","L","L4",4,"S",1,"Pre-MDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",15.328,-1.078,-3.87,5.57838,-2.638,-3.7,63,80,-1.075,9,9,0,0,"strand",3.36666666666667,8.8,0.0024435820037372,28.4570212765957,28.4570177059942,28.4308865607855,107.057952768928,22,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,-3,0,-1,-2,6,0,4,6,-0.273049645390071,-1,0.203176742254824,-0.449786871270247,-0.968586387434555,0.663157894736842,-0.885502471169687,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.152,-1.028,"9:9","146/150","F:V:L:I",3.34839479820379,4.89069202996555e-12,0.484662577645081,6.90871330415739,12.0071584873314,83.7151686983107,1.4541894385859,5.6263316435115e-18,17.2497746719749,10.8739157094292,94.2522723934353,4.32340113554558e-25,"lineage3","dr_mutations_pyrazinamide","SER",0,"ERR2510458","ERR2510458","lineage3.1.2.1","pk","Pakistan","pnca_p.leu4ser","A","E","LEU","LA4","pnca_complex.pdb"
|
|
"L4S","L4","PZA","L","L4",4,"S",NA,"MDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",15.328,-1.078,-3.87,5.57838,-2.638,-3.7,63,80,-1.075,9,9,0,0,"strand",3.36666666666667,8.8,0.0024435820037372,28.4570212765957,28.4570177059942,28.4308865607855,107.057952768928,22,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,-3,0,-1,-2,6,0,4,6,-0.273049645390071,-1,0.203176742254824,-0.449786871270247,-0.968586387434555,0.663157894736842,-0.885502471169687,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.152,-1.028,"9:9","146/150","F:V:L:I",3.34839479820379,4.89069202996555e-12,0.484662577645081,6.90871330415739,12.0071584873314,83.7151686983107,1.4541894385859,5.6263316435115e-18,17.2497746719749,10.8739157094292,94.2522723934353,4.32340113554558e-25,"lineage4","dr_mutations_pyrazinamide","SER",0,"ERR2516569","ERR2516569","lineage4.3.3","nl","Netherlands","pnca_p.leu4ser","A","E","LEU","LA4","pnca_complex.pdb"
|
|
"L4S","L2","PZA","L","L4",4,"S",1,"MDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",15.328,-1.078,-3.87,5.57838,-2.638,-3.7,63,80,-1.075,9,9,0,0,"strand",3.36666666666667,8.8,0.0024435820037372,28.4570212765957,28.4570177059942,28.4308865607855,107.057952768928,22,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,-3,0,-1,-2,6,0,4,6,-0.273049645390071,-1,0.203176742254824,-0.449786871270247,-0.968586387434555,0.663157894736842,-0.885502471169687,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.152,-1.028,"9:9","146/150","F:V:L:I",3.34839479820379,4.89069202996555e-12,0.484662577645081,6.90871330415739,12.0071584873314,83.7151686983107,1.4541894385859,5.6263316435115e-18,17.2497746719749,10.8739157094292,94.2522723934353,4.32340113554558e-25,"lineage2","dr_mutations_pyrazinamide","SER",0,"SRR2100387,SAMN03647560","SRR2100387","lineage2.2.1","","","pnca_p.leu4ser","A","E","LEU","LA4","pnca_complex.pdb"
|
|
"L4S","L2","PZA","L","L4",4,"S",0,"MDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",15.328,-1.078,-3.87,5.57838,-2.638,-3.7,63,80,-1.075,9,9,0,0,"strand",3.36666666666667,8.8,0.0024435820037372,28.4570212765957,28.4570177059942,28.4308865607855,107.057952768928,22,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,-3,0,-1,-2,6,0,4,6,-0.273049645390071,-1,0.203176742254824,-0.449786871270247,-0.968586387434555,0.663157894736842,-0.885502471169687,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.152,-1.028,"9:9","146/150","F:V:L:I",3.34839479820379,4.89069202996555e-12,0.484662577645081,6.90871330415739,12.0071584873314,83.7151686983107,1.4541894385859,5.6263316435115e-18,17.2497746719749,10.8739157094292,94.2522723934353,4.32340113554558e-25,"lineage2","dr_mutations_pyrazinamide","SER",0,"ERR2516991","ERR2516991","lineage2.2.1","gb","UK","pnca_p.leu4ser","A","E","LEU","LA4","pnca_complex.pdb"
|
|
"L4S","L2","PZA","L","L4",4,"S",0,"MDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",15.328,-1.078,-3.87,5.57838,-2.638,-3.7,63,80,-1.075,9,9,0,0,"strand",3.36666666666667,8.8,0.0024435820037372,28.4570212765957,28.4570177059942,28.4308865607855,107.057952768928,22,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,-3,0,-1,-2,6,0,4,6,-0.273049645390071,-1,0.203176742254824,-0.449786871270247,-0.968586387434555,0.663157894736842,-0.885502471169687,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.152,-1.028,"9:9","146/150","F:V:L:I",3.34839479820379,4.89069202996555e-12,0.484662577645081,6.90871330415739,12.0071584873314,83.7151686983107,1.4541894385859,5.6263316435115e-18,17.2497746719749,10.8739157094292,94.2522723934353,4.32340113554558e-25,"lineage2","dr_mutations_pyrazinamide","SER",0,"ERR2517006","ERR2517006","lineage2.2.1","gb","UK","pnca_p.leu4ser","A","E","LEU","LA4","pnca_complex.pdb"
|
|
"L4S","L2","PZA","L","L4",4,"S",1,"XDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",15.328,-1.078,-3.87,5.57838,-2.638,-3.7,63,80,-1.075,9,9,0,0,"strand",3.36666666666667,8.8,0.0024435820037372,28.4570212765957,28.4570177059942,28.4308865607855,107.057952768928,22,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,-3,0,-1,-2,6,0,4,6,-0.273049645390071,-1,0.203176742254824,-0.449786871270247,-0.968586387434555,0.663157894736842,-0.885502471169687,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.152,-1.028,"9:9","146/150","F:V:L:I",3.34839479820379,4.89069202996555e-12,0.484662577645081,6.90871330415739,12.0071584873314,83.7151686983107,1.4541894385859,5.6263316435115e-18,17.2497746719749,10.8739157094292,94.2522723934353,4.32340113554558e-25,"lineage2","dr_mutations_pyrazinamide","SER",0,"ERS1831676","ERR2041944","lineage2.2.1","","Germany_extendedCAO","pnca_p.leu4ser","A","E","LEU","LA4","pnca_complex.pdb"
|
|
"L4S","L2","PZA","L","L4",4,"S",NA,"MDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",15.328,-1.078,-3.87,5.57838,-2.638,-3.7,63,80,-1.075,9,9,0,0,"strand",3.36666666666667,8.8,0.0024435820037372,28.4570212765957,28.4570177059942,28.4308865607855,107.057952768928,22,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,-3,0,-1,-2,6,0,4,6,-0.273049645390071,-1,0.203176742254824,-0.449786871270247,-0.968586387434555,0.663157894736842,-0.885502471169687,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.152,-1.028,"9:9","146/150","F:V:L:I",3.34839479820379,4.89069202996555e-12,0.484662577645081,6.90871330415739,12.0071584873314,83.7151686983107,1.4541894385859,5.6263316435115e-18,17.2497746719749,10.8739157094292,94.2522723934353,4.32340113554558e-25,"lineage2","dr_mutations_pyrazinamide","SER",0,"ERR1023353","ERR1023353","lineage2.2.1","","","pnca_p.leu4ser","A","E","LEU","LA4","pnca_complex.pdb"
|
|
"L4S","L4","PZA","L","L4",4,"S",1,"Pre-XDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",15.328,-1.078,-3.87,5.57838,-2.638,-3.7,63,80,-1.075,9,9,0,0,"strand",3.36666666666667,8.8,0.0024435820037372,28.4570212765957,28.4570177059942,28.4308865607855,107.057952768928,22,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,-3,0,-1,-2,6,0,4,6,-0.273049645390071,-1,0.203176742254824,-0.449786871270247,-0.968586387434555,0.663157894736842,-0.885502471169687,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.152,-1.028,"9:9","146/150","F:V:L:I",3.34839479820379,4.89069202996555e-12,0.484662577645081,6.90871330415739,12.0071584873314,83.7151686983107,1.4541894385859,5.6263316435115e-18,17.2497746719749,10.8739157094292,94.2522723934353,4.32340113554558e-25,"lineage4","dr_mutations_pyrazinamide","SER",0,"ERR2513221","ERR2513221","lineage4","gb","UK","pnca_p.leu4ser","A","E","LEU","LA4","pnca_complex.pdb"
|
|
"L4S","L2","PZA","L","L4",4,"S",NA,"XDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",15.328,-1.078,-3.87,5.57838,-2.638,-3.7,63,80,-1.075,9,9,0,0,"strand",3.36666666666667,8.8,0.0024435820037372,28.4570212765957,28.4570177059942,28.4308865607855,107.057952768928,22,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,-3,0,-1,-2,6,0,4,6,-0.273049645390071,-1,0.203176742254824,-0.449786871270247,-0.968586387434555,0.663157894736842,-0.885502471169687,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.152,-1.028,"9:9","146/150","F:V:L:I",3.34839479820379,4.89069202996555e-12,0.484662577645081,6.90871330415739,12.0071584873314,83.7151686983107,1.4541894385859,5.6263316435115e-18,17.2497746719749,10.8739157094292,94.2522723934353,4.32340113554558e-25,"lineage2","dr_mutations_pyrazinamide","SER",0,"BGI_GuangZ0017,SRR671864","SRR671864","lineage2.2.1","cn","China","pnca_p.leu4ser","A","E","LEU","LA4","pnca_complex.pdb"
|
|
"L4S","L2","PZA","L","L4",4,"S",1,"MDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",15.328,-1.078,-3.87,5.57838,-2.638,-3.7,63,80,-1.075,9,9,0,0,"strand",3.36666666666667,8.8,0.0024435820037372,28.4570212765957,28.4570177059942,28.4308865607855,107.057952768928,22,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,-3,0,-1,-2,6,0,4,6,-0.273049645390071,-1,0.203176742254824,-0.449786871270247,-0.968586387434555,0.663157894736842,-0.885502471169687,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.152,-1.028,"9:9","146/150","F:V:L:I",3.34839479820379,4.89069202996555e-12,0.484662577645081,6.90871330415739,12.0071584873314,83.7151686983107,1.4541894385859,5.6263316435115e-18,17.2497746719749,10.8739157094292,94.2522723934353,4.32340113554558e-25,"lineage2","dr_mutations_pyrazinamide","SER",0,"ERR2513564","ERR2513564","lineage2.2.1","gb","UK","pnca_p.leu4ser","A","E","LEU","LA4","pnca_complex.pdb"
|
|
"L4S","L4","PZA","L","L4",4,"S",1,"MDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",15.328,-1.078,-3.87,5.57838,-2.638,-3.7,63,80,-1.075,9,9,0,0,"strand",3.36666666666667,8.8,0.0024435820037372,28.4570212765957,28.4570177059942,28.4308865607855,107.057952768928,22,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,-3,0,-1,-2,6,0,4,6,-0.273049645390071,-1,0.203176742254824,-0.449786871270247,-0.968586387434555,0.663157894736842,-0.885502471169687,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.152,-1.028,"9:9","146/150","F:V:L:I",3.34839479820379,4.89069202996555e-12,0.484662577645081,6.90871330415739,12.0071584873314,83.7151686983107,1.4541894385859,5.6263316435115e-18,17.2497746719749,10.8739157094292,94.2522723934353,4.32340113554558e-25,"lineage4","dr_mutations_pyrazinamide","SER",0,"ERS2592809","ERR2677466","lineage4.2.2.1","de","Germany","pnca_p.leu4ser","A","E","LEU","LA4","pnca_complex.pdb"
|
|
"L4S","L2","PZA","L","L4",4,"S",1,"MDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",15.328,-1.078,-3.87,5.57838,-2.638,-3.7,63,80,-1.075,9,9,0,0,"strand",3.36666666666667,8.8,0.0024435820037372,28.4570212765957,28.4570177059942,28.4308865607855,107.057952768928,22,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,-3,0,-1,-2,6,0,4,6,-0.273049645390071,-1,0.203176742254824,-0.449786871270247,-0.968586387434555,0.663157894736842,-0.885502471169687,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.152,-1.028,"9:9","146/150","F:V:L:I",3.34839479820379,4.89069202996555e-12,0.484662577645081,6.90871330415739,12.0071584873314,83.7151686983107,1.4541894385859,5.6263316435115e-18,17.2497746719749,10.8739157094292,94.2522723934353,4.32340113554558e-25,"lineage2","dr_mutations_pyrazinamide","SER",0,"ERR1034880","ERR1034880","lineage2.2.1","pt","Portugal","pnca_p.leu4ser","A","E","LEU","LA4","pnca_complex.pdb"
|
|
"L4S","L2","PZA","L","L4",4,"S",1,"MDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",15.328,-1.078,-3.87,5.57838,-2.638,-3.7,63,80,-1.075,9,9,0,0,"strand",3.36666666666667,8.8,0.0024435820037372,28.4570212765957,28.4570177059942,28.4308865607855,107.057952768928,22,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,-3,0,-1,-2,6,0,4,6,-0.273049645390071,-1,0.203176742254824,-0.449786871270247,-0.968586387434555,0.663157894736842,-0.885502471169687,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.152,-1.028,"9:9","146/150","F:V:L:I",3.34839479820379,4.89069202996555e-12,0.484662577645081,6.90871330415739,12.0071584873314,83.7151686983107,1.4541894385859,5.6263316435115e-18,17.2497746719749,10.8739157094292,94.2522723934353,4.32340113554558e-25,"lineage2","dr_mutations_pyrazinamide","SER",0,"ERR2516854","ERR2516854","lineage2.2.1","gb","UK","pnca_p.leu4ser","A","E","LEU","LA4","pnca_complex.pdb"
|
|
"L4S","L2","PZA","L","L4",4,"S",0,"MDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",15.328,-1.078,-3.87,5.57838,-2.638,-3.7,63,80,-1.075,9,9,0,0,"strand",3.36666666666667,8.8,0.0024435820037372,28.4570212765957,28.4570177059942,28.4308865607855,107.057952768928,22,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,-3,0,-1,-2,6,0,4,6,-0.273049645390071,-1,0.203176742254824,-0.449786871270247,-0.968586387434555,0.663157894736842,-0.885502471169687,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.152,-1.028,"9:9","146/150","F:V:L:I",3.34839479820379,4.89069202996555e-12,0.484662577645081,6.90871330415739,12.0071584873314,83.7151686983107,1.4541894385859,5.6263316435115e-18,17.2497746719749,10.8739157094292,94.2522723934353,4.32340113554558e-25,"lineage2","dr_mutations_pyrazinamide","SER",0,"ERR2513572","ERR2513572","lineage2.2.1","gb","UK","pnca_p.leu4ser","A","E","LEU","LA4","pnca_complex.pdb"
|
|
"L4S","L2","PZA","L","L4",4,"S",1,"MDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",15.328,-1.078,-3.87,5.57838,-2.638,-3.7,63,80,-1.075,9,9,0,0,"strand",3.36666666666667,8.8,0.0024435820037372,28.4570212765957,28.4570177059942,28.4308865607855,107.057952768928,22,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,-3,0,-1,-2,6,0,4,6,-0.273049645390071,-1,0.203176742254824,-0.449786871270247,-0.968586387434555,0.663157894736842,-0.885502471169687,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.152,-1.028,"9:9","146/150","F:V:L:I",3.34839479820379,4.89069202996555e-12,0.484662577645081,6.90871330415739,12.0071584873314,83.7151686983107,1.4541894385859,5.6263316435115e-18,17.2497746719749,10.8739157094292,94.2522723934353,4.32340113554558e-25,"lineage2","dr_mutations_pyrazinamide","SER",0,"ERR2512591","ERR2512591","lineage2.2.1","gb","UK","pnca_p.leu4ser","A","E","LEU","LA4","pnca_complex.pdb"
|
|
"L4S","L4","PZA","L","L4",4,"S",1,"Other","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",15.328,-1.078,-3.87,5.57838,-2.638,-3.7,63,80,-1.075,9,9,0,0,"strand",3.36666666666667,8.8,0.0024435820037372,28.4570212765957,28.4570177059942,28.4308865607855,107.057952768928,22,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,-3,0,-1,-2,6,0,4,6,-0.273049645390071,-1,0.203176742254824,-0.449786871270247,-0.968586387434555,0.663157894736842,-0.885502471169687,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.152,-1.028,"9:9","146/150","F:V:L:I",3.34839479820379,4.89069202996555e-12,0.484662577645081,6.90871330415739,12.0071584873314,83.7151686983107,1.4541894385859,5.6263316435115e-18,17.2497746719749,10.8739157094292,94.2522723934353,4.32340113554558e-25,"lineage4","dr_mutations_pyrazinamide","SER",0,"ERR2510742","ERR2510742","lineage4.1.2.1","it","Italy","pnca_p.leu4ser","A","E","LEU","LA4","pnca_complex.pdb"
|
|
"L4S","L2","PZA","L","L4",4,"S",1,"MDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",15.328,-1.078,-3.87,5.57838,-2.638,-3.7,63,80,-1.075,9,9,0,0,"strand",3.36666666666667,8.8,0.0024435820037372,28.4570212765957,28.4570177059942,28.4308865607855,107.057952768928,22,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,-3,0,-1,-2,6,0,4,6,-0.273049645390071,-1,0.203176742254824,-0.449786871270247,-0.968586387434555,0.663157894736842,-0.885502471169687,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.152,-1.028,"9:9","146/150","F:V:L:I",3.34839479820379,4.89069202996555e-12,0.484662577645081,6.90871330415739,12.0071584873314,83.7151686983107,1.4541894385859,5.6263316435115e-18,17.2497746719749,10.8739157094292,94.2522723934353,4.32340113554558e-25,"lineage2","dr_mutations_pyrazinamide","SER",0,"SRR2100950,SAMN03648197","SRR2100950","lineage2.2.1","","","pnca_p.leu4ser","A","E","LEU","LA4","pnca_complex.pdb"
|
|
"L4S","L3","PZA","L","L4",4,"S",1,"MDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",15.328,-1.078,-3.87,5.57838,-2.638,-3.7,63,80,-1.075,9,9,0,0,"strand",3.36666666666667,8.8,0.0024435820037372,28.4570212765957,28.4570177059942,28.4308865607855,107.057952768928,22,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,-3,0,-1,-2,6,0,4,6,-0.273049645390071,-1,0.203176742254824,-0.449786871270247,-0.968586387434555,0.663157894736842,-0.885502471169687,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.152,-1.028,"9:9","146/150","F:V:L:I",3.34839479820379,4.89069202996555e-12,0.484662577645081,6.90871330415739,12.0071584873314,83.7151686983107,1.4541894385859,5.6263316435115e-18,17.2497746719749,10.8739157094292,94.2522723934353,4.32340113554558e-25,"lineage3","dr_mutations_pyrazinamide","SER",0,"ERR2510570","ERR2510570","lineage3","pk","Pakistan","pnca_p.leu4ser","A","E","LEU","LA4","pnca_complex.pdb"
|
|
"L4S","L2","PZA","L","L4",4,"S",NA,"XDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",15.328,-1.078,-3.87,5.57838,-2.638,-3.7,63,80,-1.075,9,9,0,0,"strand",3.36666666666667,8.8,0.0024435820037372,28.4570212765957,28.4570177059942,28.4308865607855,107.057952768928,22,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,-3,0,-1,-2,6,0,4,6,-0.273049645390071,-1,0.203176742254824,-0.449786871270247,-0.968586387434555,0.663157894736842,-0.885502471169687,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.152,-1.028,"9:9","146/150","F:V:L:I",3.34839479820379,4.89069202996555e-12,0.484662577645081,6.90871330415739,12.0071584873314,83.7151686983107,1.4541894385859,5.6263316435115e-18,17.2497746719749,10.8739157094292,94.2522723934353,4.32340113554558e-25,"lineage2","dr_mutations_pyrazinamide","SER",0,"SRR5266534","SRR5266534","lineage2.2.1","ru","Russia","pnca_p.leu4ser","A","E","LEU","LA4","pnca_complex.pdb"
|
|
"L4S","L4","PZA","L","L4",4,"S",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",15.328,-1.078,-3.87,5.57838,-2.638,-3.7,63,80,-1.075,9,9,0,0,"strand",3.36666666666667,8.8,0.0024435820037372,28.4570212765957,28.4570177059942,28.4308865607855,107.057952768928,22,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,-3,0,-1,-2,6,0,4,6,-0.273049645390071,-1,0.203176742254824,-0.449786871270247,-0.968586387434555,0.663157894736842,-0.885502471169687,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.152,-1.028,"9:9","146/150","F:V:L:I",3.34839479820379,4.89069202996555e-12,0.484662577645081,6.90871330415739,12.0071584873314,83.7151686983107,1.4541894385859,5.6263316435115e-18,17.2497746719749,10.8739157094292,94.2522723934353,4.32340113554558e-25,"lineage4","dr_mutations_pyrazinamide","SER",0,"SAMN02381040","SRR1049730_SRR1140739_SRR1049729_SRR1062930","lineage4","ug","Uganda","pnca_p.leu4ser","A","E","LEU","LA4","pnca_complex.pdb"
|
|
"L4S","L2","PZA","L","L4",4,"S",1,"MDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",15.328,-1.078,-3.87,5.57838,-2.638,-3.7,63,80,-1.075,9,9,0,0,"strand",3.36666666666667,8.8,0.0024435820037372,28.4570212765957,28.4570177059942,28.4308865607855,107.057952768928,22,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,-3,0,-1,-2,6,0,4,6,-0.273049645390071,-1,0.203176742254824,-0.449786871270247,-0.968586387434555,0.663157894736842,-0.885502471169687,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.152,-1.028,"9:9","146/150","F:V:L:I",3.34839479820379,4.89069202996555e-12,0.484662577645081,6.90871330415739,12.0071584873314,83.7151686983107,1.4541894385859,5.6263316435115e-18,17.2497746719749,10.8739157094292,94.2522723934353,4.32340113554558e-25,"lineage2","dr_mutations_pyrazinamide","SER",0,"ERR2512419","ERR2512419","lineage2.2.1","gb","UK","pnca_p.leu4ser","A","E","LEU","LA4","pnca_complex.pdb"
|
|
"L4S","L2","PZA","L","L4",4,"S",NA,"XDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",15.328,-1.078,-3.87,5.57838,-2.638,-3.7,63,80,-1.075,9,9,0,0,"strand",3.36666666666667,8.8,0.0024435820037372,28.4570212765957,28.4570177059942,28.4308865607855,107.057952768928,22,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,-3,0,-1,-2,6,0,4,6,-0.273049645390071,-1,0.203176742254824,-0.449786871270247,-0.968586387434555,0.663157894736842,-0.885502471169687,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.152,-1.028,"9:9","146/150","F:V:L:I",3.34839479820379,4.89069202996555e-12,0.484662577645081,6.90871330415739,12.0071584873314,83.7151686983107,1.4541894385859,5.6263316435115e-18,17.2497746719749,10.8739157094292,94.2522723934353,4.32340113554558e-25,"lineage2","dr_mutations_pyrazinamide","SER",0,"SAMN02628490","SRR1173490_SRR1173844","lineage2.2.1","ir","Iran","pnca_p.leu4ser","A","E","LEU","LA4","pnca_complex.pdb"
|
|
"L4S","L2","PZA","L","L4",4,"S",NA,"XDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",15.328,-1.078,-3.87,5.57838,-2.638,-3.7,63,80,-1.075,9,9,0,0,"strand",3.36666666666667,8.8,0.0024435820037372,28.4570212765957,28.4570177059942,28.4308865607855,107.057952768928,22,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,-3,0,-1,-2,6,0,4,6,-0.273049645390071,-1,0.203176742254824,-0.449786871270247,-0.968586387434555,0.663157894736842,-0.885502471169687,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.152,-1.028,"9:9","146/150","F:V:L:I",3.34839479820379,4.89069202996555e-12,0.484662577645081,6.90871330415739,12.0071584873314,83.7151686983107,1.4541894385859,5.6263316435115e-18,17.2497746719749,10.8739157094292,94.2522723934353,4.32340113554558e-25,"lineage2","dr_mutations_pyrazinamide","SER",0,"SRR671789,BGI_GuangZ24","SRR671789","lineage2.2.1","cn","China","pnca_p.leu4ser","A","E","LEU","LA4","pnca_complex.pdb"
|
|
"L4S","L4","PZA","L","L4",4,"S",1,"Pre-XDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",15.328,-1.078,-3.87,5.57838,-2.638,-3.7,63,80,-1.075,9,9,0,0,"strand",3.36666666666667,8.8,0.0024435820037372,28.4570212765957,28.4570177059942,28.4308865607855,107.057952768928,22,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,-3,0,-1,-2,6,0,4,6,-0.273049645390071,-1,0.203176742254824,-0.449786871270247,-0.968586387434555,0.663157894736842,-0.885502471169687,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.152,-1.028,"9:9","146/150","F:V:L:I",3.34839479820379,4.89069202996555e-12,0.484662577645081,6.90871330415739,12.0071584873314,83.7151686983107,1.4541894385859,5.6263316435115e-18,17.2497746719749,10.8739157094292,94.2522723934353,4.32340113554558e-25,"lineage4","dr_mutations_pyrazinamide","SER",0,"ERR2514395","ERR2514395","lineage4","gb","UK","pnca_p.leu4ser","A","E","LEU","LA4","pnca_complex.pdb"
|
|
"L4S","L2","PZA","L","L4",4,"S",1,"MDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",15.328,-1.078,-3.87,5.57838,-2.638,-3.7,63,80,-1.075,9,9,0,0,"strand",3.36666666666667,8.8,0.0024435820037372,28.4570212765957,28.4570177059942,28.4308865607855,107.057952768928,22,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,-3,0,-1,-2,6,0,4,6,-0.273049645390071,-1,0.203176742254824,-0.449786871270247,-0.968586387434555,0.663157894736842,-0.885502471169687,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.152,-1.028,"9:9","146/150","F:V:L:I",3.34839479820379,4.89069202996555e-12,0.484662577645081,6.90871330415739,12.0071584873314,83.7151686983107,1.4541894385859,5.6263316435115e-18,17.2497746719749,10.8739157094292,94.2522723934353,4.32340113554558e-25,"lineage2","dr_mutations_pyrazinamide","SER",0,"ERR2516822","ERR2516822","lineage2.2.1","gb","UK","pnca_p.leu4ser","A","E","LEU","LA4","pnca_complex.pdb"
|
|
"L4S","L2","PZA","L","L4",4,"S",1,"MDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",15.328,-1.078,-3.87,5.57838,-2.638,-3.7,63,80,-1.075,9,9,0,0,"strand",3.36666666666667,8.8,0.0024435820037372,28.4570212765957,28.4570177059942,28.4308865607855,107.057952768928,22,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,-3,0,-1,-2,6,0,4,6,-0.273049645390071,-1,0.203176742254824,-0.449786871270247,-0.968586387434555,0.663157894736842,-0.885502471169687,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.152,-1.028,"9:9","146/150","F:V:L:I",3.34839479820379,4.89069202996555e-12,0.484662577645081,6.90871330415739,12.0071584873314,83.7151686983107,1.4541894385859,5.6263316435115e-18,17.2497746719749,10.8739157094292,94.2522723934353,4.32340113554558e-25,"lineage2","dr_mutations_pyrazinamide","SER",0,"ERR2517099","ERR2517099","lineage2.2.1","gb","UK","pnca_p.leu4ser","A","E","LEU","LA4","pnca_complex.pdb"
|
|
"L4S","L4","PZA","L","L4",4,"S",NA,"MDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",15.328,-1.078,-3.87,5.57838,-2.638,-3.7,63,80,-1.075,9,9,0,0,"strand",3.36666666666667,8.8,0.0024435820037372,28.4570212765957,28.4570177059942,28.4308865607855,107.057952768928,22,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,-3,0,-1,-2,6,0,4,6,-0.273049645390071,-1,0.203176742254824,-0.449786871270247,-0.968586387434555,0.663157894736842,-0.885502471169687,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.152,-1.028,"9:9","146/150","F:V:L:I",3.34839479820379,4.89069202996555e-12,0.484662577645081,6.90871330415739,12.0071584873314,83.7151686983107,1.4541894385859,5.6263316435115e-18,17.2497746719749,10.8739157094292,94.2522723934353,4.32340113554558e-25,"lineage4","dr_mutations_pyrazinamide","SER",0,"ERR2516432","ERR2516432","lineage4.3.3","nl","Netherlands","pnca_p.leu4ser","A","E","LEU","LA4","pnca_complex.pdb"
|
|
"L4S","L4","PZA","L","L4",4,"S",1,"MDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",15.328,-1.078,-3.87,5.57838,-2.638,-3.7,63,80,-1.075,9,9,0,0,"strand",3.36666666666667,8.8,0.0024435820037372,28.4570212765957,28.4570177059942,28.4308865607855,107.057952768928,22,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,-3,0,-1,-2,6,0,4,6,-0.273049645390071,-1,0.203176742254824,-0.449786871270247,-0.968586387434555,0.663157894736842,-0.885502471169687,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.152,-1.028,"9:9","146/150","F:V:L:I",3.34839479820379,4.89069202996555e-12,0.484662577645081,6.90871330415739,12.0071584873314,83.7151686983107,1.4541894385859,5.6263316435115e-18,17.2497746719749,10.8739157094292,94.2522723934353,4.32340113554558e-25,"lineage4","dr_mutations_pyrazinamide","SER",0,"ERR040137","ERR040137","lineage4.1.1.3","ug","Uganda","pnca_p.leu4ser","A","E","LEU","LA4","pnca_complex.pdb"
|
|
"L4S","L2","PZA","L","L4",4,"S",1,"MDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",15.328,-1.078,-3.87,5.57838,-2.638,-3.7,63,80,-1.075,9,9,0,0,"strand",3.36666666666667,8.8,0.0024435820037372,28.4570212765957,28.4570177059942,28.4308865607855,107.057952768928,22,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,-3,0,-1,-2,6,0,4,6,-0.273049645390071,-1,0.203176742254824,-0.449786871270247,-0.968586387434555,0.663157894736842,-0.885502471169687,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.152,-1.028,"9:9","146/150","F:V:L:I",3.34839479820379,4.89069202996555e-12,0.484662577645081,6.90871330415739,12.0071584873314,83.7151686983107,1.4541894385859,5.6263316435115e-18,17.2497746719749,10.8739157094292,94.2522723934353,4.32340113554558e-25,"lineage2","dr_mutations_pyrazinamide","SER",0,"ERR2517053","ERR2517053","lineage2.2.1","gb","UK","pnca_p.leu4ser","A","E","LEU","LA4","pnca_complex.pdb"
|
|
"L4S","L1;L4","PZA","L","L4",4,"S",NA,"Pre-MDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",15.328,-1.078,-3.87,5.57838,-2.638,-3.7,63,80,-1.075,9,9,0,0,"strand",3.36666666666667,8.8,0.0024435820037372,28.4570212765957,28.4570177059942,28.4308865607855,107.057952768928,22,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,-3,0,-1,-2,6,0,4,6,-0.273049645390071,-1,0.203176742254824,-0.449786871270247,-0.968586387434555,0.663157894736842,-0.885502471169687,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.152,-1.028,"9:9","146/150","F:V:L:I",3.34839479820379,4.89069202996555e-12,0.484662577645081,6.90871330415739,12.0071584873314,83.7151686983107,1.4541894385859,5.6263316435115e-18,17.2497746719749,10.8739157094292,94.2522723934353,4.32340113554558e-25,"lineage1;lineage4","dr_mutations_pyrazinamide","SER",0,"ERR2706927","ERR2706927","lineage4.7;lineage1.1.3","cd","Democratic Republic of Congo","pnca_p.leu4ser","A","E","LEU","LA4","pnca_complex.pdb"
|
|
"L4S","L4","PZA","L","L4",4,"S",NA,"MDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",15.328,-1.078,-3.87,5.57838,-2.638,-3.7,63,80,-1.075,9,9,0,0,"strand",3.36666666666667,8.8,0.0024435820037372,28.4570212765957,28.4570177059942,28.4308865607855,107.057952768928,22,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,-3,0,-1,-2,6,0,4,6,-0.273049645390071,-1,0.203176742254824,-0.449786871270247,-0.968586387434555,0.663157894736842,-0.885502471169687,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.152,-1.028,"9:9","146/150","F:V:L:I",3.34839479820379,4.89069202996555e-12,0.484662577645081,6.90871330415739,12.0071584873314,83.7151686983107,1.4541894385859,5.6263316435115e-18,17.2497746719749,10.8739157094292,94.2522723934353,4.32340113554558e-25,"lineage4","dr_mutations_pyrazinamide","SER",0,"ERR751550","ERR751550","lineage4.3.3","pe","","pnca_p.leu4ser","A","E","LEU","LA4","pnca_complex.pdb"
|
|
"L4S","L4","PZA","L","L4",4,"S",1,"MDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",15.328,-1.078,-3.87,5.57838,-2.638,-3.7,63,80,-1.075,9,9,0,0,"strand",3.36666666666667,8.8,0.0024435820037372,28.4570212765957,28.4570177059942,28.4308865607855,107.057952768928,22,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,-3,0,-1,-2,6,0,4,6,-0.273049645390071,-1,0.203176742254824,-0.449786871270247,-0.968586387434555,0.663157894736842,-0.885502471169687,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.152,-1.028,"9:9","146/150","F:V:L:I",3.34839479820379,4.89069202996555e-12,0.484662577645081,6.90871330415739,12.0071584873314,83.7151686983107,1.4541894385859,5.6263316435115e-18,17.2497746719749,10.8739157094292,94.2522723934353,4.32340113554558e-25,"lineage4","dr_mutations_pyrazinamide","SER",0,"ERR2516671","ERR2516671","lineage4.3.3","nl","Netherlands","pnca_p.leu4ser","A","E","LEU","LA4","pnca_complex.pdb"
|
|
"L4S","L4","PZA","L","L4",4,"S",NA,"Other","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",15.328,-1.078,-3.87,5.57838,-2.638,-3.7,63,80,-1.075,9,9,0,0,"strand",3.36666666666667,8.8,0.0024435820037372,28.4570212765957,28.4570177059942,28.4308865607855,107.057952768928,22,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,-3,0,-1,-2,6,0,4,6,-0.273049645390071,-1,0.203176742254824,-0.449786871270247,-0.968586387434555,0.663157894736842,-0.885502471169687,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.152,-1.028,"9:9","146/150","F:V:L:I",3.34839479820379,4.89069202996555e-12,0.484662577645081,6.90871330415739,12.0071584873314,83.7151686983107,1.4541894385859,5.6263316435115e-18,17.2497746719749,10.8739157094292,94.2522723934353,4.32340113554558e-25,"lineage4","dr_mutations_pyrazinamide","SER",0,"SRR4035802","SRR4035802","lineage4.1.2","za","South Africa: Kwazulu-Natal","pnca_p.leu4ser","A","E","LEU","LA4","pnca_complex.pdb"
|
|
"L4S","L1","PZA","L","L4",4,"S",NA,"MDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",15.328,-1.078,-3.87,5.57838,-2.638,-3.7,63,80,-1.075,9,9,0,0,"strand",3.36666666666667,8.8,0.0024435820037372,28.4570212765957,28.4570177059942,28.4308865607855,107.057952768928,22,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,-3,0,-1,-2,6,0,4,6,-0.273049645390071,-1,0.203176742254824,-0.449786871270247,-0.968586387434555,0.663157894736842,-0.885502471169687,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.152,-1.028,"9:9","146/150","F:V:L:I",3.34839479820379,4.89069202996555e-12,0.484662577645081,6.90871330415739,12.0071584873314,83.7151686983107,1.4541894385859,5.6263316435115e-18,17.2497746719749,10.8739157094292,94.2522723934353,4.32340113554558e-25,"lineage1","dr_mutations_pyrazinamide","SER",0,"SRR6397957","SRR6397957","lineage1.2.1","ca","Canada","pnca_p.leu4ser","A","E","LEU","LA4","pnca_complex.pdb"
|
|
"L4S","L2","PZA","L","L4",4,"S",0,"MDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",15.328,-1.078,-3.87,5.57838,-2.638,-3.7,63,80,-1.075,9,9,0,0,"strand",3.36666666666667,8.8,0.0024435820037372,28.4570212765957,28.4570177059942,28.4308865607855,107.057952768928,22,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,-3,0,-1,-2,6,0,4,6,-0.273049645390071,-1,0.203176742254824,-0.449786871270247,-0.968586387434555,0.663157894736842,-0.885502471169687,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.152,-1.028,"9:9","146/150","F:V:L:I",3.34839479820379,4.89069202996555e-12,0.484662577645081,6.90871330415739,12.0071584873314,83.7151686983107,1.4541894385859,5.6263316435115e-18,17.2497746719749,10.8739157094292,94.2522723934353,4.32340113554558e-25,"lineage2","dr_mutations_pyrazinamide","SER",0,"ERR2516916","ERR2516916","lineage2.2.1","gb","UK","pnca_p.leu4ser","A","E","LEU","LA4","pnca_complex.pdb"
|
|
"L4S","L4","PZA","L","L4",4,"S",NA,"MDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",15.328,-1.078,-3.87,5.57838,-2.638,-3.7,63,80,-1.075,9,9,0,0,"strand",3.36666666666667,8.8,0.0024435820037372,28.4570212765957,28.4570177059942,28.4308865607855,107.057952768928,22,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,-3,0,-1,-2,6,0,4,6,-0.273049645390071,-1,0.203176742254824,-0.449786871270247,-0.968586387434555,0.663157894736842,-0.885502471169687,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.152,-1.028,"9:9","146/150","F:V:L:I",3.34839479820379,4.89069202996555e-12,0.484662577645081,6.90871330415739,12.0071584873314,83.7151686983107,1.4541894385859,5.6263316435115e-18,17.2497746719749,10.8739157094292,94.2522723934353,4.32340113554558e-25,"lineage4","dr_mutations_pyrazinamide","SER",0,"ERR3256132","ERR3256132","lineage4.5","ph","Philippines","pnca_p.leu4ser","A","E","LEU","LA4","pnca_complex.pdb"
|
|
"L4S","L2","PZA","L","L4",4,"S",NA,"MDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",15.328,-1.078,-3.87,5.57838,-2.638,-3.7,63,80,-1.075,9,9,0,0,"strand",3.36666666666667,8.8,0.0024435820037372,28.4570212765957,28.4570177059942,28.4308865607855,107.057952768928,22,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,-3,0,-1,-2,6,0,4,6,-0.273049645390071,-1,0.203176742254824,-0.449786871270247,-0.968586387434555,0.663157894736842,-0.885502471169687,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.152,-1.028,"9:9","146/150","F:V:L:I",3.34839479820379,4.89069202996555e-12,0.484662577645081,6.90871330415739,12.0071584873314,83.7151686983107,1.4541894385859,5.6263316435115e-18,17.2497746719749,10.8739157094292,94.2522723934353,4.32340113554558e-25,"lineage2","dr_mutations_pyrazinamide","SER",0,"SAMN02414900","SRR1163039_SRR1163448_SRR1146378_SRR1144756","lineage2.2.1","se","Sweden","pnca_p.leu4ser","A","E","LEU","LA4","pnca_complex.pdb"
|
|
"L4S","L2","PZA","L","L4",4,"S",NA,"XDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",15.328,-1.078,-3.87,5.57838,-2.638,-3.7,63,80,-1.075,9,9,0,0,"strand",3.36666666666667,8.8,0.0024435820037372,28.4570212765957,28.4570177059942,28.4308865607855,107.057952768928,22,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,-3,0,-1,-2,6,0,4,6,-0.273049645390071,-1,0.203176742254824,-0.449786871270247,-0.968586387434555,0.663157894736842,-0.885502471169687,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.152,-1.028,"9:9","146/150","F:V:L:I",3.34839479820379,4.89069202996555e-12,0.484662577645081,6.90871330415739,12.0071584873314,83.7151686983107,1.4541894385859,5.6263316435115e-18,17.2497746719749,10.8739157094292,94.2522723934353,4.32340113554558e-25,"lineage2","dr_mutations_pyrazinamide","SER",0,"SRR671863,BGI_GuangZ0008","SRR671863","lineage2.2.1","cn","China","pnca_p.leu4ser","A","E","LEU","LA4","pnca_complex.pdb"
|
|
"L4S","L4","PZA","L","L4",4,"S",NA,"MDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",15.328,-1.078,-3.87,5.57838,-2.638,-3.7,63,80,-1.075,9,9,0,0,"strand",3.36666666666667,8.8,0.0024435820037372,28.4570212765957,28.4570177059942,28.4308865607855,107.057952768928,22,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,-3,0,-1,-2,6,0,4,6,-0.273049645390071,-1,0.203176742254824,-0.449786871270247,-0.968586387434555,0.663157894736842,-0.885502471169687,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.152,-1.028,"9:9","146/150","F:V:L:I",3.34839479820379,4.89069202996555e-12,0.484662577645081,6.90871330415739,12.0071584873314,83.7151686983107,1.4541894385859,5.6263316435115e-18,17.2497746719749,10.8739157094292,94.2522723934353,4.32340113554558e-25,"lineage4","dr_mutations_pyrazinamide","SER",0,"ERR1193648","ERR1193648","lineage4.3.3","so","Somalia","pnca_p.leu4ser","A","E","LEU","LA4","pnca_complex.pdb"
|
|
"L4S","L2","PZA","L","L4",4,"S",1,"MDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",15.328,-1.078,-3.87,5.57838,-2.638,-3.7,63,80,-1.075,9,9,0,0,"strand",3.36666666666667,8.8,0.0024435820037372,28.4570212765957,28.4570177059942,28.4308865607855,107.057952768928,22,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,-3,0,-1,-2,6,0,4,6,-0.273049645390071,-1,0.203176742254824,-0.449786871270247,-0.968586387434555,0.663157894736842,-0.885502471169687,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.152,-1.028,"9:9","146/150","F:V:L:I",3.34839479820379,4.89069202996555e-12,0.484662577645081,6.90871330415739,12.0071584873314,83.7151686983107,1.4541894385859,5.6263316435115e-18,17.2497746719749,10.8739157094292,94.2522723934353,4.32340113554558e-25,"lineage2","dr_mutations_pyrazinamide","SER",0,"SRR2100306,SAMN03647479","SRR2100306","lineage2.2.1","","","pnca_p.leu4ser","A","E","LEU","LA4","pnca_complex.pdb"
|
|
"L4S","L4","PZA","L","L4",4,"S",NA,"MDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",15.328,-1.078,-3.87,5.57838,-2.638,-3.7,63,80,-1.075,9,9,0,0,"strand",3.36666666666667,8.8,0.0024435820037372,28.4570212765957,28.4570177059942,28.4308865607855,107.057952768928,22,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,-3,0,-1,-2,6,0,4,6,-0.273049645390071,-1,0.203176742254824,-0.449786871270247,-0.968586387434555,0.663157894736842,-0.885502471169687,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.152,-1.028,"9:9","146/150","F:V:L:I",3.34839479820379,4.89069202996555e-12,0.484662577645081,6.90871330415739,12.0071584873314,83.7151686983107,1.4541894385859,5.6263316435115e-18,17.2497746719749,10.8739157094292,94.2522723934353,4.32340113554558e-25,"lineage4","dr_mutations_pyrazinamide","SER",0,"SRR7517813","SRR7517813","lineage4.3.3","pe","Peru","pnca_p.leu4ser","A","E","LEU","LA4","pnca_complex.pdb"
|
|
"L4S","L4","PZA","L","L4",4,"S",0,"MDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",15.328,-1.078,-3.87,5.57838,-2.638,-3.7,63,80,-1.075,9,9,0,0,"strand",3.36666666666667,8.8,0.0024435820037372,28.4570212765957,28.4570177059942,28.4308865607855,107.057952768928,22,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,-3,0,-1,-2,6,0,4,6,-0.273049645390071,-1,0.203176742254824,-0.449786871270247,-0.968586387434555,0.663157894736842,-0.885502471169687,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.152,-1.028,"9:9","146/150","F:V:L:I",3.34839479820379,4.89069202996555e-12,0.484662577645081,6.90871330415739,12.0071584873314,83.7151686983107,1.4541894385859,5.6263316435115e-18,17.2497746719749,10.8739157094292,94.2522723934353,4.32340113554558e-25,"lineage4","dr_mutations_pyrazinamide","SER",0,"ERR2516552","ERR2516552","lineage4.3.3","pe","Peru","pnca_p.leu4ser","A","E","LEU","LA4","pnca_complex.pdb"
|
|
"L4S","L2","PZA","L","L4",4,"S",1,"MDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",15.328,-1.078,-3.87,5.57838,-2.638,-3.7,63,80,-1.075,9,9,0,0,"strand",3.36666666666667,8.8,0.0024435820037372,28.4570212765957,28.4570177059942,28.4308865607855,107.057952768928,22,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,-3,0,-1,-2,6,0,4,6,-0.273049645390071,-1,0.203176742254824,-0.449786871270247,-0.968586387434555,0.663157894736842,-0.885502471169687,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.152,-1.028,"9:9","146/150","F:V:L:I",3.34839479820379,4.89069202996555e-12,0.484662577645081,6.90871330415739,12.0071584873314,83.7151686983107,1.4541894385859,5.6263316435115e-18,17.2497746719749,10.8739157094292,94.2522723934353,4.32340113554558e-25,"lineage2","dr_mutations_pyrazinamide","SER",0,"ERR2516882","ERR2516882","lineage2.2.1","gb","UK","pnca_p.leu4ser","A","E","LEU","LA4","pnca_complex.pdb"
|
|
"L4S","L4","PZA","L","L4",4,"S",1,"MDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",15.328,-1.078,-3.87,5.57838,-2.638,-3.7,63,80,-1.075,9,9,0,0,"strand",3.36666666666667,8.8,0.0024435820037372,28.4570212765957,28.4570177059942,28.4308865607855,107.057952768928,22,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,-3,0,-1,-2,6,0,4,6,-0.273049645390071,-1,0.203176742254824,-0.449786871270247,-0.968586387434555,0.663157894736842,-0.885502471169687,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.152,-1.028,"9:9","146/150","F:V:L:I",3.34839479820379,4.89069202996555e-12,0.484662577645081,6.90871330415739,12.0071584873314,83.7151686983107,1.4541894385859,5.6263316435115e-18,17.2497746719749,10.8739157094292,94.2522723934353,4.32340113554558e-25,"lineage4","dr_mutations_pyrazinamide","SER",0,"ERR2516638","ERR2516638","lineage4.3.3","nl","Netherlands","pnca_p.leu4ser","A","E","LEU","LA4","pnca_complex.pdb"
|
|
"L4S","L2","PZA","L","L4",4,"S",1,"MDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",15.328,-1.078,-3.87,5.57838,-2.638,-3.7,63,80,-1.075,9,9,0,0,"strand",3.36666666666667,8.8,0.0024435820037372,28.4570212765957,28.4570177059942,28.4308865607855,107.057952768928,22,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,-3,0,-1,-2,6,0,4,6,-0.273049645390071,-1,0.203176742254824,-0.449786871270247,-0.968586387434555,0.663157894736842,-0.885502471169687,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.152,-1.028,"9:9","146/150","F:V:L:I",3.34839479820379,4.89069202996555e-12,0.484662577645081,6.90871330415739,12.0071584873314,83.7151686983107,1.4541894385859,5.6263316435115e-18,17.2497746719749,10.8739157094292,94.2522723934353,4.32340113554558e-25,"lineage2","dr_mutations_pyrazinamide","SER",0,"ERR2513835","ERR2513835","lineage2.2.1","gb","UK","pnca_p.leu4ser","A","E","LEU","LA4","pnca_complex.pdb"
|
|
"L4S","L4","PZA","L","L4",4,"S",NA,"MDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",15.328,-1.078,-3.87,5.57838,-2.638,-3.7,63,80,-1.075,9,9,0,0,"strand",3.36666666666667,8.8,0.0024435820037372,28.4570212765957,28.4570177059942,28.4308865607855,107.057952768928,22,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,-3,0,-1,-2,6,0,4,6,-0.273049645390071,-1,0.203176742254824,-0.449786871270247,-0.968586387434555,0.663157894736842,-0.885502471169687,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.152,-1.028,"9:9","146/150","F:V:L:I",3.34839479820379,4.89069202996555e-12,0.484662577645081,6.90871330415739,12.0071584873314,83.7151686983107,1.4541894385859,5.6263316435115e-18,17.2497746719749,10.8739157094292,94.2522723934353,4.32340113554558e-25,"lineage4","dr_mutations_pyrazinamide","SER",0,"ERR2707005","ERR2707005","lineage4.7","cd","Democratic Republic of Congo","pnca_p.leu4ser","A","E","LEU","LA4","pnca_complex.pdb"
|
|
"L4S","L2","PZA","L","L4",4,"S",1,"Pre-XDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",15.328,-1.078,-3.87,5.57838,-2.638,-3.7,63,80,-1.075,9,9,0,0,"strand",3.36666666666667,8.8,0.0024435820037372,28.4570212765957,28.4570177059942,28.4308865607855,107.057952768928,22,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,-3,0,-1,-2,6,0,4,6,-0.273049645390071,-1,0.203176742254824,-0.449786871270247,-0.968586387434555,0.663157894736842,-0.885502471169687,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.152,-1.028,"9:9","146/150","F:V:L:I",3.34839479820379,4.89069202996555e-12,0.484662577645081,6.90871330415739,12.0071584873314,83.7151686983107,1.4541894385859,5.6263316435115e-18,17.2497746719749,10.8739157094292,94.2522723934353,4.32340113554558e-25,"lineage2","dr_mutations_pyrazinamide","SER",0,"ERS2592754","ERR2677405","lineage2.2.1","de","Germany","pnca_p.leu4ser","A","E","LEU","LA4","pnca_complex.pdb"
|
|
"L4S","L4","PZA","L","L4",4,"S",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",15.328,-1.078,-3.87,5.57838,-2.638,-3.7,63,80,-1.075,9,9,0,0,"strand",3.36666666666667,8.8,0.0024435820037372,28.4570212765957,28.4570177059942,28.4308865607855,107.057952768928,22,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,-3,0,-1,-2,6,0,4,6,-0.273049645390071,-1,0.203176742254824,-0.449786871270247,-0.968586387434555,0.663157894736842,-0.885502471169687,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.152,-1.028,"9:9","146/150","F:V:L:I",3.34839479820379,4.89069202996555e-12,0.484662577645081,6.90871330415739,12.0071584873314,83.7151686983107,1.4541894385859,5.6263316435115e-18,17.2497746719749,10.8739157094292,94.2522723934353,4.32340113554558e-25,"lineage4","dr_mutations_pyrazinamide","SER",0,"SAMN07236257,SRR5710013","SRR5710013","lineage4.4.2","th","Thailand","pnca_p.leu4ser","A","E","LEU","LA4","pnca_complex.pdb"
|
|
"L4S","L2","PZA","L","L4",4,"S",1,"MDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",15.328,-1.078,-3.87,5.57838,-2.638,-3.7,63,80,-1.075,9,9,0,0,"strand",3.36666666666667,8.8,0.0024435820037372,28.4570212765957,28.4570177059942,28.4308865607855,107.057952768928,22,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,-3,0,-1,-2,6,0,4,6,-0.273049645390071,-1,0.203176742254824,-0.449786871270247,-0.968586387434555,0.663157894736842,-0.885502471169687,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.152,-1.028,"9:9","146/150","F:V:L:I",3.34839479820379,4.89069202996555e-12,0.484662577645081,6.90871330415739,12.0071584873314,83.7151686983107,1.4541894385859,5.6263316435115e-18,17.2497746719749,10.8739157094292,94.2522723934353,4.32340113554558e-25,"lineage2","dr_mutations_pyrazinamide","SER",0,"SAMN03647142","SRR2099969","lineage2.2.1","","","pnca_p.leu4ser","A","E","LEU","LA4","pnca_complex.pdb"
|
|
"L4S","L2","PZA","L","L4",4,"S",1,"MDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",15.328,-1.078,-3.87,5.57838,-2.638,-3.7,63,80,-1.075,9,9,0,0,"strand",3.36666666666667,8.8,0.0024435820037372,28.4570212765957,28.4570177059942,28.4308865607855,107.057952768928,22,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,-3,0,-1,-2,6,0,4,6,-0.273049645390071,-1,0.203176742254824,-0.449786871270247,-0.968586387434555,0.663157894736842,-0.885502471169687,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.152,-1.028,"9:9","146/150","F:V:L:I",3.34839479820379,4.89069202996555e-12,0.484662577645081,6.90871330415739,12.0071584873314,83.7151686983107,1.4541894385859,5.6263316435115e-18,17.2497746719749,10.8739157094292,94.2522723934353,4.32340113554558e-25,"lineage2","dr_mutations_pyrazinamide","SER",0,"ERR2516979","ERR2516979","lineage2.2.1","gb","UK","pnca_p.leu4ser","A","E","LEU","LA4","pnca_complex.pdb"
|
|
"L4S","L2","PZA","L","L4",4,"S",1,"MDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",15.328,-1.078,-3.87,5.57838,-2.638,-3.7,63,80,-1.075,9,9,0,0,"strand",3.36666666666667,8.8,0.0024435820037372,28.4570212765957,28.4570177059942,28.4308865607855,107.057952768928,22,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,-3,0,-1,-2,6,0,4,6,-0.273049645390071,-1,0.203176742254824,-0.449786871270247,-0.968586387434555,0.663157894736842,-0.885502471169687,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.152,-1.028,"9:9","146/150","F:V:L:I",3.34839479820379,4.89069202996555e-12,0.484662577645081,6.90871330415739,12.0071584873314,83.7151686983107,1.4541894385859,5.6263316435115e-18,17.2497746719749,10.8739157094292,94.2522723934353,4.32340113554558e-25,"lineage2","dr_mutations_pyrazinamide","SER",0,"ERR2516927","ERR2516927","lineage2.2.1","gb","UK","pnca_p.leu4ser","A","E","LEU","LA4","pnca_complex.pdb"
|
|
"L4S","L2","PZA","L","L4",4,"S",NA,"MDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",15.328,-1.078,-3.87,5.57838,-2.638,-3.7,63,80,-1.075,9,9,0,0,"strand",3.36666666666667,8.8,0.0024435820037372,28.4570212765957,28.4570177059942,28.4308865607855,107.057952768928,22,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,-3,0,-1,-2,6,0,4,6,-0.273049645390071,-1,0.203176742254824,-0.449786871270247,-0.968586387434555,0.663157894736842,-0.885502471169687,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.152,-1.028,"9:9","146/150","F:V:L:I",3.34839479820379,4.89069202996555e-12,0.484662577645081,6.90871330415739,12.0071584873314,83.7151686983107,1.4541894385859,5.6263316435115e-18,17.2497746719749,10.8739157094292,94.2522723934353,4.32340113554558e-25,"lineage2","dr_mutations_pyrazinamide","SER",0,"SRR6397408","SRR6397408","lineage2.2.1.1","ca","Canada","pnca_p.leu4ser","A","E","LEU","LA4","pnca_complex.pdb"
|
|
"L4S","L4","PZA","L","L4",4,"S",1,"MDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",15.328,-1.078,-3.87,5.57838,-2.638,-3.7,63,80,-1.075,9,9,0,0,"strand",3.36666666666667,8.8,0.0024435820037372,28.4570212765957,28.4570177059942,28.4308865607855,107.057952768928,22,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,-3,0,-1,-2,6,0,4,6,-0.273049645390071,-1,0.203176742254824,-0.449786871270247,-0.968586387434555,0.663157894736842,-0.885502471169687,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.152,-1.028,"9:9","146/150","F:V:L:I",3.34839479820379,4.89069202996555e-12,0.484662577645081,6.90871330415739,12.0071584873314,83.7151686983107,1.4541894385859,5.6263316435115e-18,17.2497746719749,10.8739157094292,94.2522723934353,4.32340113554558e-25,"lineage4","dr_mutations_pyrazinamide","SER",0,"ERS2592806","ERR2677462","lineage4.2.2.1","de","Germany","pnca_p.leu4ser","A","E","LEU","LA4","pnca_complex.pdb"
|
|
"L4V","L6","PZA","L","L4",4,"V",NA,"MDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",15.328,-2.828,-1.717,1.19624,-1.68,-1.95,22,63,-1.075,9,9,0,0,"strand",3.36666666666667,8.8,NA,NA,NA,NA,NA,22,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-3,0,-1,-2,2,0,0,0,-0.716312056737589,-0.443669250645995,0.043569664697441,-0.286445012787724,-0.510471204188482,0.231578947368421,-0.885502471169687,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.152,-1.028,"9:9","146/150","F:V:L:I",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage6","other_mutations_pyrazinamide","VAL",0,"ERR1215461","ERR1215461","lineage6","gh","Ghana","pnca_p.leu4val","A","E","LEU","LA4","pnca_complex.pdb"
|
|
"L4W","L2","PZA","L","L4",4,"W",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",15.328,-2.216,-2.169,1.63111,-2.168,-1.93,70,85,-1.075,9,9,0,0,"strand",3.36666666666667,8.8,0.0012217910018686,22.7551797040169,22.7551786098964,22.7463684762183,46.6274188614457,-46,6,0,0,6,0,0,0,0,0,0,0,0,0,0,0,0,-15,0,-7,-8,0,0,-16,2,-0.5612968591692,-0.56046511627907,0.0594085766941776,-0.369650468883205,-0.505235602094241,0.736842105263158,-0.885502471169687,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.152,-1.028,"9:9","146/150","F:V:L:I",3.12479275069714,9.15103299018708e-07,0.636534850451638,4.90906782005734,7.42096527532349,98.7712876576624,1.35708026960092,7.15795820641824e-09,8.14521084167875,6.3414443600848,123.179124931302,8.58505795592483e-12,"lineage2","dr_mutations_pyrazinamide","TRP",0,"ERR3275831","ERR3275831","lineage2.2.1","nl","Netherlands","pnca_p.leu4trp","A","E","LEU","LA4","pnca_complex.pdb"
|
|
"L4W","L1","PZA","L","L4",4,"W",0,"MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",15.328,-2.216,-2.169,1.63111,-2.168,-1.93,70,85,-1.075,9,9,0,0,"strand",3.36666666666667,8.8,0.0012217910018686,22.7551797040169,22.7551786098964,22.7463684762183,46.6274188614457,-46,6,0,0,6,0,0,0,0,0,0,0,0,0,0,0,0,-15,0,-7,-8,0,0,-16,2,-0.5612968591692,-0.56046511627907,0.0594085766941776,-0.369650468883205,-0.505235602094241,0.736842105263158,-0.885502471169687,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.152,-1.028,"9:9","146/150","F:V:L:I",3.12479275069714,9.15103299018708e-07,0.636534850451638,4.90906782005734,7.42096527532349,98.7712876576624,1.35708026960092,7.15795820641824e-09,8.14521084167875,6.3414443600848,123.179124931302,8.58505795592483e-12,"lineage1","dr_mutations_pyrazinamide","TRP",0,"ERR2516881","ERR2516881","lineage1.1.3","gb","UK","pnca_p.leu4trp","A","E","LEU","LA4","pnca_complex.pdb"
|
|
"L4W","L4","PZA","L","L4",4,"W",1,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",15.328,-2.216,-2.169,1.63111,-2.168,-1.93,70,85,-1.075,9,9,0,0,"strand",3.36666666666667,8.8,0.0012217910018686,22.7551797040169,22.7551786098964,22.7463684762183,46.6274188614457,-46,6,0,0,6,0,0,0,0,0,0,0,0,0,0,0,0,-15,0,-7,-8,0,0,-16,2,-0.5612968591692,-0.56046511627907,0.0594085766941776,-0.369650468883205,-0.505235602094241,0.736842105263158,-0.885502471169687,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.152,-1.028,"9:9","146/150","F:V:L:I",3.12479275069714,9.15103299018708e-07,0.636534850451638,4.90906782005734,7.42096527532349,98.7712876576624,1.35708026960092,7.15795820641824e-09,8.14521084167875,6.3414443600848,123.179124931302,8.58505795592483e-12,"lineage4","dr_mutations_pyrazinamide","TRP",0,"18710","ERR3014623","lineage4.1.2.1","tn","Tunisia:Bizerte","pnca_p.leu4trp","A","E","LEU","LA4","pnca_complex.pdb"
|
|
"L4W","L1","PZA","L","L4",4,"W",0,"MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",15.328,-2.216,-2.169,1.63111,-2.168,-1.93,70,85,-1.075,9,9,0,0,"strand",3.36666666666667,8.8,0.0012217910018686,22.7551797040169,22.7551786098964,22.7463684762183,46.6274188614457,-46,6,0,0,6,0,0,0,0,0,0,0,0,0,0,0,0,-15,0,-7,-8,0,0,-16,2,-0.5612968591692,-0.56046511627907,0.0594085766941776,-0.369650468883205,-0.505235602094241,0.736842105263158,-0.885502471169687,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.152,-1.028,"9:9","146/150","F:V:L:I",3.12479275069714,9.15103299018708e-07,0.636534850451638,4.90906782005734,7.42096527532349,98.7712876576624,1.35708026960092,7.15795820641824e-09,8.14521084167875,6.3414443600848,123.179124931302,8.58505795592483e-12,"lineage1","dr_mutations_pyrazinamide","TRP",0,"ERR2516763","ERR2516763","lineage1.1.3","gb","UK","pnca_p.leu4trp","A","E","LEU","LA4","pnca_complex.pdb"
|
|
"L4W","L4","PZA","L","L4",4,"W",1,"MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",15.328,-2.216,-2.169,1.63111,-2.168,-1.93,70,85,-1.075,9,9,0,0,"strand",3.36666666666667,8.8,0.0012217910018686,22.7551797040169,22.7551786098964,22.7463684762183,46.6274188614457,-46,6,0,0,6,0,0,0,0,0,0,0,0,0,0,0,0,-15,0,-7,-8,0,0,-16,2,-0.5612968591692,-0.56046511627907,0.0594085766941776,-0.369650468883205,-0.505235602094241,0.736842105263158,-0.885502471169687,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.152,-1.028,"9:9","146/150","F:V:L:I",3.12479275069714,9.15103299018708e-07,0.636534850451638,4.90906782005734,7.42096527532349,98.7712876576624,1.35708026960092,7.15795820641824e-09,8.14521084167875,6.3414443600848,123.179124931302,8.58505795592483e-12,"lineage4","dr_mutations_pyrazinamide","TRP",0,"13916","ERR3014609","lineage4.1.2.1","tn","Tunisia:Beja","pnca_p.leu4trp","A","E","LEU","LA4","pnca_complex.pdb"
|
|
"L4W","L2","PZA","L","L4",4,"W",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",15.328,-2.216,-2.169,1.63111,-2.168,-1.93,70,85,-1.075,9,9,0,0,"strand",3.36666666666667,8.8,0.0012217910018686,22.7551797040169,22.7551786098964,22.7463684762183,46.6274188614457,-46,6,0,0,6,0,0,0,0,0,0,0,0,0,0,0,0,-15,0,-7,-8,0,0,-16,2,-0.5612968591692,-0.56046511627907,0.0594085766941776,-0.369650468883205,-0.505235602094241,0.736842105263158,-0.885502471169687,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.152,-1.028,"9:9","146/150","F:V:L:I",3.12479275069714,9.15103299018708e-07,0.636534850451638,4.90906782005734,7.42096527532349,98.7712876576624,1.35708026960092,7.15795820641824e-09,8.14521084167875,6.3414443600848,123.179124931302,8.58505795592483e-12,"lineage2","dr_mutations_pyrazinamide","TRP",0,"SRS796975","SRR1723462","lineage2.2.1","cn","China:Guizhou","pnca_p.leu4trp","A","E","LEU","LA4","pnca_complex.pdb"
|
|
"L4W","L1","PZA","L","L4",4,"W",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",15.328,-2.216,-2.169,1.63111,-2.168,-1.93,70,85,-1.075,9,9,0,0,"strand",3.36666666666667,8.8,0.0012217910018686,22.7551797040169,22.7551786098964,22.7463684762183,46.6274188614457,-46,6,0,0,6,0,0,0,0,0,0,0,0,0,0,0,0,-15,0,-7,-8,0,0,-16,2,-0.5612968591692,-0.56046511627907,0.0594085766941776,-0.369650468883205,-0.505235602094241,0.736842105263158,-0.885502471169687,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.152,-1.028,"9:9","146/150","F:V:L:I",3.12479275069714,9.15103299018708e-07,0.636534850451638,4.90906782005734,7.42096527532349,98.7712876576624,1.35708026960092,7.15795820641824e-09,8.14521084167875,6.3414443600848,123.179124931302,8.58505795592483e-12,"lineage1","dr_mutations_pyrazinamide","TRP",0,"SRR8380866","SRR8380866","lineage1.1.2","in","India","pnca_p.leu4trp","A","E","LEU","LA4","pnca_complex.pdb"
|
|
"L4W","L2;L4","PZA","L","L4",4,"W",1,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",15.328,-2.216,-2.169,1.63111,-2.168,-1.93,70,85,-1.075,9,9,0,0,"strand",3.36666666666667,8.8,0.0012217910018686,22.7551797040169,22.7551786098964,22.7463684762183,46.6274188614457,-46,6,0,0,6,0,0,0,0,0,0,0,0,0,0,0,0,-15,0,-7,-8,0,0,-16,2,-0.5612968591692,-0.56046511627907,0.0594085766941776,-0.369650468883205,-0.505235602094241,0.736842105263158,-0.885502471169687,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.152,-1.028,"9:9","146/150","F:V:L:I",3.12479275069714,9.15103299018708e-07,0.636534850451638,4.90906782005734,7.42096527532349,98.7712876576624,1.35708026960092,7.15795820641824e-09,8.14521084167875,6.3414443600848,123.179124931302,8.58505795592483e-12,"lineage2;lineage4","dr_mutations_pyrazinamide","TRP",0,"1735M-sc-2012-02-21T11:37:09Z-1364763,ERR137271","ERR137271","lineage4.2.1;lineage2.2.1","ru","Russia,Samara","pnca_p.leu4trp","A","E","LEU","LA4","pnca_complex.pdb"
|
|
"L4W","L4","PZA","L","L4",4,"W",1,"MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",15.328,-2.216,-2.169,1.63111,-2.168,-1.93,70,85,-1.075,9,9,0,0,"strand",3.36666666666667,8.8,0.0012217910018686,22.7551797040169,22.7551786098964,22.7463684762183,46.6274188614457,-46,6,0,0,6,0,0,0,0,0,0,0,0,0,0,0,0,-15,0,-7,-8,0,0,-16,2,-0.5612968591692,-0.56046511627907,0.0594085766941776,-0.369650468883205,-0.505235602094241,0.736842105263158,-0.885502471169687,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.152,-1.028,"9:9","146/150","F:V:L:I",3.12479275069714,9.15103299018708e-07,0.636534850451638,4.90906782005734,7.42096527532349,98.7712876576624,1.35708026960092,7.15795820641824e-09,8.14521084167875,6.3414443600848,123.179124931302,8.58505795592483e-12,"lineage4","dr_mutations_pyrazinamide","TRP",0,"13878","ERR3014608","lineage4.1.2.1","tn","Tunisia:Bizerte","pnca_p.leu4trp","A","E","LEU","LA4","pnca_complex.pdb"
|
|
"L4W","L2","PZA","L","L4",4,"W",1,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",15.328,-2.216,-2.169,1.63111,-2.168,-1.93,70,85,-1.075,9,9,0,0,"strand",3.36666666666667,8.8,0.0012217910018686,22.7551797040169,22.7551786098964,22.7463684762183,46.6274188614457,-46,6,0,0,6,0,0,0,0,0,0,0,0,0,0,0,0,-15,0,-7,-8,0,0,-16,2,-0.5612968591692,-0.56046511627907,0.0594085766941776,-0.369650468883205,-0.505235602094241,0.736842105263158,-0.885502471169687,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.152,-1.028,"9:9","146/150","F:V:L:I",3.12479275069714,9.15103299018708e-07,0.636534850451638,4.90906782005734,7.42096527532349,98.7712876576624,1.35708026960092,7.15795820641824e-09,8.14521084167875,6.3414443600848,123.179124931302,8.58505795592483e-12,"lineage2","dr_mutations_pyrazinamide","TRP",0,"SAMN10961363","SRR8651607","lineage2.2.1","cn","China:Wenzhou","pnca_p.leu4trp","A","E","LEU","LA4","pnca_complex.pdb"
|
|
"L4W","L2","PZA","L","L4",4,"W",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",15.328,-2.216,-2.169,1.63111,-2.168,-1.93,70,85,-1.075,9,9,0,0,"strand",3.36666666666667,8.8,0.0012217910018686,22.7551797040169,22.7551786098964,22.7463684762183,46.6274188614457,-46,6,0,0,6,0,0,0,0,0,0,0,0,0,0,0,0,-15,0,-7,-8,0,0,-16,2,-0.5612968591692,-0.56046511627907,0.0594085766941776,-0.369650468883205,-0.505235602094241,0.736842105263158,-0.885502471169687,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.152,-1.028,"9:9","146/150","F:V:L:I",3.12479275069714,9.15103299018708e-07,0.636534850451638,4.90906782005734,7.42096527532349,98.7712876576624,1.35708026960092,7.15795820641824e-09,8.14521084167875,6.3414443600848,123.179124931302,8.58505795592483e-12,"lineage2","dr_mutations_pyrazinamide","TRP",0,"ERR137236,1477G-sc-2012-02-21T11:36:45Z-1364728","ERR137236","lineage2.2.1","ru","Russia","pnca_p.leu4trp","A","E","LEU","LA4","pnca_complex.pdb"
|
|
"L4W","L2","PZA","L","L4",4,"W",NA,"XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",15.328,-2.216,-2.169,1.63111,-2.168,-1.93,70,85,-1.075,9,9,0,0,"strand",3.36666666666667,8.8,0.0012217910018686,22.7551797040169,22.7551786098964,22.7463684762183,46.6274188614457,-46,6,0,0,6,0,0,0,0,0,0,0,0,0,0,0,0,-15,0,-7,-8,0,0,-16,2,-0.5612968591692,-0.56046511627907,0.0594085766941776,-0.369650468883205,-0.505235602094241,0.736842105263158,-0.885502471169687,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.152,-1.028,"9:9","146/150","F:V:L:I",3.12479275069714,9.15103299018708e-07,0.636534850451638,4.90906782005734,7.42096527532349,98.7712876576624,1.35708026960092,7.15795820641824e-09,8.14521084167875,6.3414443600848,123.179124931302,8.58505795592483e-12,"lineage2","dr_mutations_pyrazinamide","TRP",0,"SAMN02398703","SRR1144796_SRR1047989","lineage2.2.2","kr","South Korea","pnca_p.leu4trp","A","E","LEU","LA4","pnca_complex.pdb"
|
|
"L4W","L2","PZA","L","L4",4,"W",1,"XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",15.328,-2.216,-2.169,1.63111,-2.168,-1.93,70,85,-1.075,9,9,0,0,"strand",3.36666666666667,8.8,0.0012217910018686,22.7551797040169,22.7551786098964,22.7463684762183,46.6274188614457,-46,6,0,0,6,0,0,0,0,0,0,0,0,0,0,0,0,-15,0,-7,-8,0,0,-16,2,-0.5612968591692,-0.56046511627907,0.0594085766941776,-0.369650468883205,-0.505235602094241,0.736842105263158,-0.885502471169687,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.152,-1.028,"9:9","146/150","F:V:L:I",3.12479275069714,9.15103299018708e-07,0.636534850451638,4.90906782005734,7.42096527532349,98.7712876576624,1.35708026960092,7.15795820641824e-09,8.14521084167875,6.3414443600848,123.179124931302,8.58505795592483e-12,"lineage2","dr_mutations_pyrazinamide","TRP",0,"SAMN10961353","SRR8651594","lineage2.2.1","cn","China:Wenzhou","pnca_p.leu4trp","A","E","LEU","LA4","pnca_complex.pdb"
|
|
"L4W","L2","PZA","L","L4",4,"W",1,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",15.328,-2.216,-2.169,1.63111,-2.168,-1.93,70,85,-1.075,9,9,0,0,"strand",3.36666666666667,8.8,0.0012217910018686,22.7551797040169,22.7551786098964,22.7463684762183,46.6274188614457,-46,6,0,0,6,0,0,0,0,0,0,0,0,0,0,0,0,-15,0,-7,-8,0,0,-16,2,-0.5612968591692,-0.56046511627907,0.0594085766941776,-0.369650468883205,-0.505235602094241,0.736842105263158,-0.885502471169687,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.152,-1.028,"9:9","146/150","F:V:L:I",3.12479275069714,9.15103299018708e-07,0.636534850451638,4.90906782005734,7.42096527532349,98.7712876576624,1.35708026960092,7.15795820641824e-09,8.14521084167875,6.3414443600848,123.179124931302,8.58505795592483e-12,"lineage2","dr_mutations_pyrazinamide","TRP",0,"MDR_24272","SRR6824542","lineage2.2.1","cn","China: Bijie City, Guizhou Province","pnca_p.leu4trp","A","E","LEU","LA4","pnca_complex.pdb"
|
|
"L4W","L2","PZA","L","L4",4,"W",NA,"XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",15.328,-2.216,-2.169,1.63111,-2.168,-1.93,70,85,-1.075,9,9,0,0,"strand",3.36666666666667,8.8,0.0012217910018686,22.7551797040169,22.7551786098964,22.7463684762183,46.6274188614457,-46,6,0,0,6,0,0,0,0,0,0,0,0,0,0,0,0,-15,0,-7,-8,0,0,-16,2,-0.5612968591692,-0.56046511627907,0.0594085766941776,-0.369650468883205,-0.505235602094241,0.736842105263158,-0.885502471169687,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.152,-1.028,"9:9","146/150","F:V:L:I",3.12479275069714,9.15103299018708e-07,0.636534850451638,4.90906782005734,7.42096527532349,98.7712876576624,1.35708026960092,7.15795820641824e-09,8.14521084167875,6.3414443600848,123.179124931302,8.58505795592483e-12,"lineage2","dr_mutations_pyrazinamide","TRP",0,"SAMN07236540,SRR5710028","SRR5710028","lineage2.2.1","th","Thailand","pnca_p.leu4trp","A","E","LEU","LA4","pnca_complex.pdb"
|
|
"L4W","L2","PZA","L","L4",4,"W",1,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",15.328,-2.216,-2.169,1.63111,-2.168,-1.93,70,85,-1.075,9,9,0,0,"strand",3.36666666666667,8.8,0.0012217910018686,22.7551797040169,22.7551786098964,22.7463684762183,46.6274188614457,-46,6,0,0,6,0,0,0,0,0,0,0,0,0,0,0,0,-15,0,-7,-8,0,0,-16,2,-0.5612968591692,-0.56046511627907,0.0594085766941776,-0.369650468883205,-0.505235602094241,0.736842105263158,-0.885502471169687,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.152,-1.028,"9:9","146/150","F:V:L:I",3.12479275069714,9.15103299018708e-07,0.636534850451638,4.90906782005734,7.42096527532349,98.7712876576624,1.35708026960092,7.15795820641824e-09,8.14521084167875,6.3414443600848,123.179124931302,8.58505795592483e-12,"lineage2","dr_mutations_pyrazinamide","TRP",0,"SAMN10961319","SRR8651646","lineage2.2.1","cn","China:Wenzhou","pnca_p.leu4trp","A","E","LEU","LA4","pnca_complex.pdb"
|
|
"L4W","L4","PZA","L","L4",4,"W",1,"MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",15.328,-2.216,-2.169,1.63111,-2.168,-1.93,70,85,-1.075,9,9,0,0,"strand",3.36666666666667,8.8,0.0012217910018686,22.7551797040169,22.7551786098964,22.7463684762183,46.6274188614457,-46,6,0,0,6,0,0,0,0,0,0,0,0,0,0,0,0,-15,0,-7,-8,0,0,-16,2,-0.5612968591692,-0.56046511627907,0.0594085766941776,-0.369650468883205,-0.505235602094241,0.736842105263158,-0.885502471169687,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.152,-1.028,"9:9","146/150","F:V:L:I",3.12479275069714,9.15103299018708e-07,0.636534850451638,4.90906782005734,7.42096527532349,98.7712876576624,1.35708026960092,7.15795820641824e-09,8.14521084167875,6.3414443600848,123.179124931302,8.58505795592483e-12,"lineage4","dr_mutations_pyrazinamide","TRP",0,"19367","ERR3014625","lineage4.1.2.1","tn","Tunisia:Tunis","pnca_p.leu4trp","A","E","LEU","LA4","pnca_complex.pdb"
|
|
"L4W","L2","PZA","L","L4",4,"W",1,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",15.328,-2.216,-2.169,1.63111,-2.168,-1.93,70,85,-1.075,9,9,0,0,"strand",3.36666666666667,8.8,0.0012217910018686,22.7551797040169,22.7551786098964,22.7463684762183,46.6274188614457,-46,6,0,0,6,0,0,0,0,0,0,0,0,0,0,0,0,-15,0,-7,-8,0,0,-16,2,-0.5612968591692,-0.56046511627907,0.0594085766941776,-0.369650468883205,-0.505235602094241,0.736842105263158,-0.885502471169687,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.152,-1.028,"9:9","146/150","F:V:L:I",3.12479275069714,9.15103299018708e-07,0.636534850451638,4.90906782005734,7.42096527532349,98.7712876576624,1.35708026960092,7.15795820641824e-09,8.14521084167875,6.3414443600848,123.179124931302,8.58505795592483e-12,"lineage2","dr_mutations_pyrazinamide","TRP",0,"SAMN10961329","SRR8651661","lineage2.2.1","cn","China:Wenzhou","pnca_p.leu4trp","A","E","LEU","LA4","pnca_complex.pdb"
|
|
"L4W","L3","PZA","L","L4",4,"W",1,"MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",15.328,-2.216,-2.169,1.63111,-2.168,-1.93,70,85,-1.075,9,9,0,0,"strand",3.36666666666667,8.8,0.0012217910018686,22.7551797040169,22.7551786098964,22.7463684762183,46.6274188614457,-46,6,0,0,6,0,0,0,0,0,0,0,0,0,0,0,0,-15,0,-7,-8,0,0,-16,2,-0.5612968591692,-0.56046511627907,0.0594085766941776,-0.369650468883205,-0.505235602094241,0.736842105263158,-0.885502471169687,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.152,-1.028,"9:9","146/150","F:V:L:I",3.12479275069714,9.15103299018708e-07,0.636534850451638,4.90906782005734,7.42096527532349,98.7712876576624,1.35708026960092,7.15795820641824e-09,8.14521084167875,6.3414443600848,123.179124931302,8.58505795592483e-12,"lineage3","dr_mutations_pyrazinamide","TRP",0,"ERR2510522","ERR2510522","lineage3","pk","Pakistan","pnca_p.leu4trp","A","E","LEU","LA4","pnca_complex.pdb"
|
|
"L4W","L4","PZA","L","L4",4,"W",1,"MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",15.328,-2.216,-2.169,1.63111,-2.168,-1.93,70,85,-1.075,9,9,0,0,"strand",3.36666666666667,8.8,0.0012217910018686,22.7551797040169,22.7551786098964,22.7463684762183,46.6274188614457,-46,6,0,0,6,0,0,0,0,0,0,0,0,0,0,0,0,-15,0,-7,-8,0,0,-16,2,-0.5612968591692,-0.56046511627907,0.0594085766941776,-0.369650468883205,-0.505235602094241,0.736842105263158,-0.885502471169687,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.152,-1.028,"9:9","146/150","F:V:L:I",3.12479275069714,9.15103299018708e-07,0.636534850451638,4.90906782005734,7.42096527532349,98.7712876576624,1.35708026960092,7.15795820641824e-09,8.14521084167875,6.3414443600848,123.179124931302,8.58505795592483e-12,"lineage4","dr_mutations_pyrazinamide","TRP",0,"18013","ERR3014620","lineage4.1.2.1","tn","Tunisia:Sousse","pnca_p.leu4trp","A","E","LEU","LA4","pnca_complex.pdb"
|
|
"L4W","L1","PZA","L","L4",4,"W",0,"MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",15.328,-2.216,-2.169,1.63111,-2.168,-1.93,70,85,-1.075,9,9,0,0,"strand",3.36666666666667,8.8,0.0012217910018686,22.7551797040169,22.7551786098964,22.7463684762183,46.6274188614457,-46,6,0,0,6,0,0,0,0,0,0,0,0,0,0,0,0,-15,0,-7,-8,0,0,-16,2,-0.5612968591692,-0.56046511627907,0.0594085766941776,-0.369650468883205,-0.505235602094241,0.736842105263158,-0.885502471169687,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.152,-1.028,"9:9","146/150","F:V:L:I",3.12479275069714,9.15103299018708e-07,0.636534850451638,4.90906782005734,7.42096527532349,98.7712876576624,1.35708026960092,7.15795820641824e-09,8.14521084167875,6.3414443600848,123.179124931302,8.58505795592483e-12,"lineage1","dr_mutations_pyrazinamide","TRP",0,"ERR2516833","ERR2516833","lineage1.1.3","gb","UK","pnca_p.leu4trp","A","E","LEU","LA4","pnca_complex.pdb"
|
|
"L4W","L4","PZA","L","L4",4,"W",1,"MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",15.328,-2.216,-2.169,1.63111,-2.168,-1.93,70,85,-1.075,9,9,0,0,"strand",3.36666666666667,8.8,0.0012217910018686,22.7551797040169,22.7551786098964,22.7463684762183,46.6274188614457,-46,6,0,0,6,0,0,0,0,0,0,0,0,0,0,0,0,-15,0,-7,-8,0,0,-16,2,-0.5612968591692,-0.56046511627907,0.0594085766941776,-0.369650468883205,-0.505235602094241,0.736842105263158,-0.885502471169687,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.152,-1.028,"9:9","146/150","F:V:L:I",3.12479275069714,9.15103299018708e-07,0.636534850451638,4.90906782005734,7.42096527532349,98.7712876576624,1.35708026960092,7.15795820641824e-09,8.14521084167875,6.3414443600848,123.179124931302,8.58505795592483e-12,"lineage4","dr_mutations_pyrazinamide","TRP",0,"2666","ERR3014584","lineage4.1.2.1","tn","Tunisia:Sousse","pnca_p.leu4trp","A","E","LEU","LA4","pnca_complex.pdb"
|
|
"L4W","L2","PZA","L","L4",4,"W",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",15.328,-2.216,-2.169,1.63111,-2.168,-1.93,70,85,-1.075,9,9,0,0,"strand",3.36666666666667,8.8,0.0012217910018686,22.7551797040169,22.7551786098964,22.7463684762183,46.6274188614457,-46,6,0,0,6,0,0,0,0,0,0,0,0,0,0,0,0,-15,0,-7,-8,0,0,-16,2,-0.5612968591692,-0.56046511627907,0.0594085766941776,-0.369650468883205,-0.505235602094241,0.736842105263158,-0.885502471169687,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.152,-1.028,"9:9","146/150","F:V:L:I",3.12479275069714,9.15103299018708e-07,0.636534850451638,4.90906782005734,7.42096527532349,98.7712876576624,1.35708026960092,7.15795820641824e-09,8.14521084167875,6.3414443600848,123.179124931302,8.58505795592483e-12,"lineage2","dr_mutations_pyrazinamide","TRP",0,"SRR5710014,SAMN07236287","SRR5710014","lineage2.2.1","th","Thailand","pnca_p.leu4trp","A","E","LEU","LA4","pnca_complex.pdb"
|
|
"L4W","L4","PZA","L","L4",4,"W",1,"MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",15.328,-2.216,-2.169,1.63111,-2.168,-1.93,70,85,-1.075,9,9,0,0,"strand",3.36666666666667,8.8,0.0012217910018686,22.7551797040169,22.7551786098964,22.7463684762183,46.6274188614457,-46,6,0,0,6,0,0,0,0,0,0,0,0,0,0,0,0,-15,0,-7,-8,0,0,-16,2,-0.5612968591692,-0.56046511627907,0.0594085766941776,-0.369650468883205,-0.505235602094241,0.736842105263158,-0.885502471169687,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.152,-1.028,"9:9","146/150","F:V:L:I",3.12479275069714,9.15103299018708e-07,0.636534850451638,4.90906782005734,7.42096527532349,98.7712876576624,1.35708026960092,7.15795820641824e-09,8.14521084167875,6.3414443600848,123.179124931302,8.58505795592483e-12,"lineage4","dr_mutations_pyrazinamide","TRP",0,"16260","ERR3014615","lineage4.1.2.1","tn","Tunisia:Nabeul","pnca_p.leu4trp","A","E","LEU","LA4","pnca_complex.pdb"
|
|
"I5S","L4","PZA","I","I5",5,"S",NA,"MDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",11.437,-0.778,-3.843,5.83176,-3.518,-3.58,63,80,-0.011,5,5,0,0,"strand",4.26666666666667,12.6,7.18700589334483e-05,9.70142977291842,188179.92626441,Inf,0.763784339928386,30,0,0,0,0,0,0,0,0,0,0,-4,0,0,0,0,0,4,0,2,2,0,0,4,0,-0.197061803444782,-0.993023255813954,0.212405393395931,-0.599829497016198,-0.93717277486911,0.663157894736842,-0.00906095551894563,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.244,0.083,"6:5","146/150","G:F:I:L:V",12.1451538387253,0.919026337424193,119.46804443616,0.101660271548307,5.0115366606943e-06,NA,0.986835744238421,0.170978870202674,0.767057556984365,0.124324963210678,Inf,0.382146811758261,"lineage4","dr_mutations_pyrazinamide","SER",0,"ERR2179669","ERR2179669","lineage4.4","cn","China","pnca_p.ile5ser","A","E","ILE","IA5","pnca_complex.pdb"
|
|
"I5S","L4","PZA","I","I5",5,"S",NA,"MDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",11.437,-0.778,-3.843,5.83176,-3.518,-3.58,63,80,-0.011,5,5,0,0,"strand",4.26666666666667,12.6,7.18700589334483e-05,9.70142977291842,188179.92626441,Inf,0.763784339928386,30,0,0,0,0,0,0,0,0,0,0,-4,0,0,0,0,0,4,0,2,2,0,0,4,0,-0.197061803444782,-0.993023255813954,0.212405393395931,-0.599829497016198,-0.93717277486911,0.663157894736842,-0.00906095551894563,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.244,0.083,"6:5","146/150","G:F:I:L:V",12.1451538387253,0.919026337424193,119.46804443616,0.101660271548307,5.0115366606943e-06,NA,0.986835744238421,0.170978870202674,0.767057556984365,0.124324963210678,Inf,0.382146811758261,"lineage4","dr_mutations_pyrazinamide","SER",0,"ERR502939","ERR502939","lineage4.4","","","pnca_p.ile5ser","A","E","ILE","IA5","pnca_complex.pdb"
|
|
"I5S","L4","PZA","I","I5",5,"S",NA,"MDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",11.437,-0.778,-3.843,5.83176,-3.518,-3.58,63,80,-0.011,5,5,0,0,"strand",4.26666666666667,12.6,7.18700589334483e-05,9.70142977291842,188179.92626441,Inf,0.763784339928386,30,0,0,0,0,0,0,0,0,0,0,-4,0,0,0,0,0,4,0,2,2,0,0,4,0,-0.197061803444782,-0.993023255813954,0.212405393395931,-0.599829497016198,-0.93717277486911,0.663157894736842,-0.00906095551894563,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.244,0.083,"6:5","146/150","G:F:I:L:V",12.1451538387253,0.919026337424193,119.46804443616,0.101660271548307,5.0115366606943e-06,NA,0.986835744238421,0.170978870202674,0.767057556984365,0.124324963210678,Inf,0.382146811758261,"lineage4","dr_mutations_pyrazinamide","SER",0,"SRS797458","SRR1723998","lineage4.4","cn","China:Hunan","pnca_p.ile5ser","A","E","ILE","IA5","pnca_complex.pdb"
|
|
"I5S","L2","PZA","I","I5",5,"S",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",11.437,-0.778,-3.843,5.83176,-3.518,-3.58,63,80,-0.011,5,5,0,0,"strand",4.26666666666667,12.6,7.18700589334483e-05,9.70142977291842,188179.92626441,Inf,0.763784339928386,30,0,0,0,0,0,0,0,0,0,0,-4,0,0,0,0,0,4,0,2,2,0,0,4,0,-0.197061803444782,-0.993023255813954,0.212405393395931,-0.599829497016198,-0.93717277486911,0.663157894736842,-0.00906095551894563,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.244,0.083,"6:5","146/150","G:F:I:L:V",12.1451538387253,0.919026337424193,119.46804443616,0.101660271548307,5.0115366606943e-06,NA,0.986835744238421,0.170978870202674,0.767057556984365,0.124324963210678,Inf,0.382146811758261,"lineage2","dr_mutations_pyrazinamide","SER",0,"ERR751650","ERR751650","lineage2.2.1","th","Thailand","pnca_p.ile5ser","A","E","ILE","IA5","pnca_complex.pdb"
|
|
"I5S","L4","PZA","I","I5",5,"S",1,"MDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",11.437,-0.778,-3.843,5.83176,-3.518,-3.58,63,80,-0.011,5,5,0,0,"strand",4.26666666666667,12.6,7.18700589334483e-05,9.70142977291842,188179.92626441,Inf,0.763784339928386,30,0,0,0,0,0,0,0,0,0,0,-4,0,0,0,0,0,4,0,2,2,0,0,4,0,-0.197061803444782,-0.993023255813954,0.212405393395931,-0.599829497016198,-0.93717277486911,0.663157894736842,-0.00906095551894563,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.244,0.083,"6:5","146/150","G:F:I:L:V",12.1451538387253,0.919026337424193,119.46804443616,0.101660271548307,5.0115366606943e-06,NA,0.986835744238421,0.170978870202674,0.767057556984365,0.124324963210678,Inf,0.382146811758261,"lineage4","dr_mutations_pyrazinamide","SER",0,"MDR_18568","SRR6824524","lineage4.4","cn","China: Leiyang City, Hengyang City, Hunan Province","pnca_p.ile5ser","A","E","ILE","IA5","pnca_complex.pdb"
|
|
"I5S","L2","PZA","I","I5",5,"S",NA,"XDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",11.437,-0.778,-3.843,5.83176,-3.518,-3.58,63,80,-0.011,5,5,0,0,"strand",4.26666666666667,12.6,7.18700589334483e-05,9.70142977291842,188179.92626441,Inf,0.763784339928386,30,0,0,0,0,0,0,0,0,0,0,-4,0,0,0,0,0,4,0,2,2,0,0,4,0,-0.197061803444782,-0.993023255813954,0.212405393395931,-0.599829497016198,-0.93717277486911,0.663157894736842,-0.00906095551894563,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.244,0.083,"6:5","146/150","G:F:I:L:V",12.1451538387253,0.919026337424193,119.46804443616,0.101660271548307,5.0115366606943e-06,NA,0.986835744238421,0.170978870202674,0.767057556984365,0.124324963210678,Inf,0.382146811758261,"lineage2","dr_mutations_pyrazinamide","SER",0,"SRR8380939","SRR8380939","lineage2.2.1","in","India","pnca_p.ile5ser","A","E","ILE","IA5","pnca_complex.pdb"
|
|
"I5T","L1","PZA","I","I5",5,"T",1,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",11.437,-0.945,-3.43,3.67776,-2.709,-3.3,63,80,-0.011,5,5,0,0,"strand",4.26666666666667,12.6,0.0002874802357337,14.5631313131313,14.5630810302278,14.5631012253236,5.81873994206135,32,0,0,0,0,0,0,0,0,0,0,-4,0,0,0,0,0,4,0,2,2,0,0,4,0,-0.23936170212766,-0.886304909560723,0.133952024708805,-0.461892583120205,-0.863874345549738,0.663157894736842,-0.00906095551894563,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.244,0.083,"6:5","146/150","G:F:I:L:V",2.67848962960141,0.0202679102821362,1.15384949648317,2.3213509541454,1.86363317860697,294.488177946116,1.16325476548539,0.0174140488202037,1.75910024233227,1.16837785201846,760.989759542733,0.0158563003544608,"lineage1","dr_mutations_pyrazinamide","THR",0,"ERR2510512","ERR2510512","lineage1.2.2","pk","Pakistan","pnca_p.ile5thr","A","E","ILE","IA5","pnca_complex.pdb"
|
|
"I5T","L4","PZA","I","I5",5,"T",0,"XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",11.437,-0.945,-3.43,3.67776,-2.709,-3.3,63,80,-0.011,5,5,0,0,"strand",4.26666666666667,12.6,0.0002874802357337,14.5631313131313,14.5630810302278,14.5631012253236,5.81873994206135,32,0,0,0,0,0,0,0,0,0,0,-4,0,0,0,0,0,4,0,2,2,0,0,4,0,-0.23936170212766,-0.886304909560723,0.133952024708805,-0.461892583120205,-0.863874345549738,0.663157894736842,-0.00906095551894563,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.244,0.083,"6:5","146/150","G:F:I:L:V",2.67848962960141,0.0202679102821362,1.15384949648317,2.3213509541454,1.86363317860697,294.488177946116,1.16325476548539,0.0174140488202037,1.75910024233227,1.16837785201846,760.989759542733,0.0158563003544608,"lineage4","dr_mutations_pyrazinamide","THR",0,"ERR2041730","ERR2041730","lineage4.8","rs","Serbia","pnca_p.ile5thr","A","E","ILE","IA5","pnca_complex.pdb"
|
|
"I5T","L1","PZA","I","I5",5,"T",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",11.437,-0.945,-3.43,3.67776,-2.709,-3.3,63,80,-0.011,5,5,0,0,"strand",4.26666666666667,12.6,0.0002874802357337,14.5631313131313,14.5630810302278,14.5631012253236,5.81873994206135,32,0,0,0,0,0,0,0,0,0,0,-4,0,0,0,0,0,4,0,2,2,0,0,4,0,-0.23936170212766,-0.886304909560723,0.133952024708805,-0.461892583120205,-0.863874345549738,0.663157894736842,-0.00906095551894563,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.244,0.083,"6:5","146/150","G:F:I:L:V",2.67848962960141,0.0202679102821362,1.15384949648317,2.3213509541454,1.86363317860697,294.488177946116,1.16325476548539,0.0174140488202037,1.75910024233227,1.16837785201846,760.989759542733,0.0158563003544608,"lineage1","dr_mutations_pyrazinamide","THR",0,"SAMN02599179","SRR1172873_SRR1172848","lineage1.1.2","in","India","pnca_p.ile5thr","A","E","ILE","IA5","pnca_complex.pdb"
|
|
"I5T","L2","PZA","I","I5",5,"T",1,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",11.437,-0.945,-3.43,3.67776,-2.709,-3.3,63,80,-0.011,5,5,0,0,"strand",4.26666666666667,12.6,0.0002874802357337,14.5631313131313,14.5630810302278,14.5631012253236,5.81873994206135,32,0,0,0,0,0,0,0,0,0,0,-4,0,0,0,0,0,4,0,2,2,0,0,4,0,-0.23936170212766,-0.886304909560723,0.133952024708805,-0.461892583120205,-0.863874345549738,0.663157894736842,-0.00906095551894563,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.244,0.083,"6:5","146/150","G:F:I:L:V",2.67848962960141,0.0202679102821362,1.15384949648317,2.3213509541454,1.86363317860697,294.488177946116,1.16325476548539,0.0174140488202037,1.75910024233227,1.16837785201846,760.989759542733,0.0158563003544608,"lineage2","dr_mutations_pyrazinamide","THR",0,"SAMN10961352","SRR8651582","lineage2.2.1","cn","China:Wenzhou","pnca_p.ile5thr","A","E","ILE","IA5","pnca_complex.pdb"
|
|
"I5T","L4","PZA","I","I5",5,"T",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",11.437,-0.945,-3.43,3.67776,-2.709,-3.3,63,80,-0.011,5,5,0,0,"strand",4.26666666666667,12.6,0.0002874802357337,14.5631313131313,14.5630810302278,14.5631012253236,5.81873994206135,32,0,0,0,0,0,0,0,0,0,0,-4,0,0,0,0,0,4,0,2,2,0,0,4,0,-0.23936170212766,-0.886304909560723,0.133952024708805,-0.461892583120205,-0.863874345549738,0.663157894736842,-0.00906095551894563,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.244,0.083,"6:5","146/150","G:F:I:L:V",2.67848962960141,0.0202679102821362,1.15384949648317,2.3213509541454,1.86363317860697,294.488177946116,1.16325476548539,0.0174140488202037,1.75910024233227,1.16837785201846,760.989759542733,0.0158563003544608,"lineage4","dr_mutations_pyrazinamide","THR",0,"ERR779880","ERR779880","lineage4.3.4.2","pe","","pnca_p.ile5thr","A","E","ILE","IA5","pnca_complex.pdb"
|
|
"I5T","L4","PZA","I","I5",5,"T",1,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",11.437,-0.945,-3.43,3.67776,-2.709,-3.3,63,80,-0.011,5,5,0,0,"strand",4.26666666666667,12.6,0.0002874802357337,14.5631313131313,14.5630810302278,14.5631012253236,5.81873994206135,32,0,0,0,0,0,0,0,0,0,0,-4,0,0,0,0,0,4,0,2,2,0,0,4,0,-0.23936170212766,-0.886304909560723,0.133952024708805,-0.461892583120205,-0.863874345549738,0.663157894736842,-0.00906095551894563,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.244,0.083,"6:5","146/150","G:F:I:L:V",2.67848962960141,0.0202679102821362,1.15384949648317,2.3213509541454,1.86363317860697,294.488177946116,1.16325476548539,0.0174140488202037,1.75910024233227,1.16837785201846,760.989759542733,0.0158563003544608,"lineage4","dr_mutations_pyrazinamide","THR",0,"ERR551126,ERS457122,4148-04","ERR551126","lineage4.1.2.1","","","pnca_p.ile5thr","A","E","ILE","IA5","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",NA,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"ERR067611,0341X-sc-2011-09-07T13:19:07Z-1276458","ERR067611","lineage2.2.1","ru","Russia","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",0,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"ERR133839,0293V-sc-2012-02-09T18:55:51Z-1355172","ERR133839","lineage2.2.1","ru","Russia,Samara","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",0,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"ERR144633,2073E-sc-2012-02-21T11:38:30Z-1364871","ERR144633","lineage2.2.1","ru","Russia,Samara","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",0,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"ERR133902,0669D-sc-2012-02-09T18:56:41Z-1355235","ERR133902","lineage2.2.1","ru","Russia,Samara","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",1,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"1409H-sc-2012-02-21T11:36:37Z-1364717,ERR137225","ERR137225","lineage2.2.1","ru","Russia,Samara","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",0,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"ERR067721,0188F-sc-2011-08-25T12:38:23Z-1262320","ERR067721","lineage2.2.1","ru","Russia,Samara","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",NA,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"1239Y-sc-2011-09-07T13:20:01Z-1276545,ERR067698","ERR067698","lineage2.2.1","ru","Russia","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",1,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"0696H-sc-2012-02-09T18:56:44Z-1355239,ERR133906","ERR133906","lineage2.2.1","ru","Russia,Samara","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",0,"XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"ERR234598,0322B-sc-2012-10-11T13:36:31Z-1494084","ERR234598","lineage2.2.1","ru","Russia,Samara","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",0,"XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"ERR144551,1802K-sc-2012-02-21T11:37:27Z-1364788","ERR144551","lineage2.2.1","ru","Russia,Samara","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",0,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"0405R-sc-2012-02-09T18:56:06Z-1355193,ERR133860","ERR133860","lineage2.2.1","ru","Russia,Samara","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",0,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"2335P-sc-2012-10-11T13:38:47Z-1494225,ERR228061","ERR228061","lineage2.2.1","ru","Russia,Samara","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",0,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"0406S-sc-2011-08-25T12:38:37Z-1262341,ERR067742","ERR067742","lineage2.2.1","ru","Russia,Samara","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",0,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"ERR133959,0869W-sc-2012-02-09T18:57:22Z-1355292","ERR133959","lineage2.2.1","ru","Russia,Samara","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2;L4","PZA","I","I6",6,"L",0,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2;lineage4","other_mutations_pyrazinamide","LEU",0,"1815Z-sc-2012-02-21T11:37:31Z-1364793,ERR144556","ERR144556","lineage4;lineage2.2.1","ru","Russia,Samara","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",NA,"XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"ERR144591","ERR144591","lineage2.2.1","ru","Russia","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",0,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"0367A-sc-2011-09-07T13:19:59Z-1276542,ERR067695","ERR067695","lineage2.2.1","ru","Russia,Samara","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",0,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"2140C-sc-2012-04-10T09:16:23Z-1397804,ERR158592","ERR158592","lineage2.2.1","ru","Russia,Samara","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",0,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"0458Z-sc-2012-02-09T18:56:10Z-1355199,ERR133866","ERR133866","lineage2.2.1","ru","Russia,Samara","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",0,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"2325D-sc-2012-10-11T13:38:01Z-1494177,ERR228013","ERR228013","lineage2.2.1","ru","Russia,Samara","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",NA,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"ERR137237,1502J-sc-2012-02-21T11:36:46Z-1364729","ERR137237","lineage2.2.1","ru","Russia","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",0,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"ERR228029,2327F-sc-2012-10-11T13:38:16Z-1494193","ERR228029","lineage2.2.1","ru","Russia,Samara","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",0,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"0664Y-sc-2012-10-11T13:36:35Z-1494088,ERR234602","ERR234602","lineage2.2.1","ru","Russia","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",0,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"ERR108493,1126A-sc-2011-10-12T14:59:23Z-1289158","ERR108493","lineage2.2.1","ru","Russia,Samara","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",0,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"0556F-sc-2012-02-09T18:56:24Z-1355218,ERR133885","ERR133885","lineage2.2.1","ru","Russia,Samara","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",0,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"ERR144561,1824J-sc-2012-02-21T11:37:34Z-1364798","ERR144561","lineage2.2.1","ru","Russia,Samara","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",0,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"ERR229966,2393C-sc-2012-10-11T13:39:45Z-1494285","ERR229966","lineage2.2.1","ru","Russia,Samara","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",0,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"0915W-sc-2011-09-07T13:19:46Z-1276520,ERR067673","ERR067673","lineage2.2.1","ru","Russia,Samara","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",NA,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"ERR230009","ERR230009","lineage2.2.1","ru","Russia","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",NA,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"ERR137226","ERR137226","lineage2.2.1","ru","Russia","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",0,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"ERR067758,0508D-sc-2011-08-25T12:38:45Z-1262357","ERR067758","lineage2.2.1","ru","Russia,Samara","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",NA,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"ERR144615,2020X-sc-2012-02-21T11:38:18Z-1364852","ERR144615","lineage2.2.1","ru","Russia","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",0,"XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"0389Z-sc-2012-02-09T18:56:02Z-1355187,ERR133854","ERR133854","lineage2.2.1","ru","Russia,Samara","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",0,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"ERR108473,0967C-sc-2011-10-12T14:59:08Z-1289138","ERR108473","lineage2.2.1","ru","Russia,Samara","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",0,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"0761D-sc-2011-10-12T14:59:04Z-1289132,ERR108467","ERR108467","lineage2.2.1","ru","Russia,Samara","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",0,"XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"ERR234653,2525W-sc-2012-10-11T13:40:29Z-1494331","ERR234653","lineage2.2.1","ru","Russia,Samara","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",0,"XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"ERR234596,0040V-sc-2012-10-11T13:36:29Z-1494082","ERR234596","lineage2.2.1","ru","Russia,Samara","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",0,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"2491J-sc-2012-10-11T13:39:02Z-1494240,ERR229921","ERR229921","lineage2.2.1","ru","Russia,Samara","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",1,"XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"0514K-sc-2011-09-07T13:18:57Z-1276439,ERR067592","ERR067592","lineage2.2.1","ru","Russia,Samara","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",0,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"ERR234595,1355Z-sc-2012-10-11T13:36:28Z-1494081","ERR234595","lineage2.2.1","ru","Russia","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",0,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"0622C-sc-2012-10-11T13:36:26Z-1494079,ERR234593","ERR234593","lineage2.2.1","ru","Russia,Samara","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",0,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"1723Z-sc-2011-10-12T14:59:54Z-1289202,ERR117468","ERR117468","lineage2.2.1","ru","Russia,Samara","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",0,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"2234E-sc-2012-10-11T13:38:05Z-1494181,ERR228017","ERR228017","lineage2.2.1","ru","Russia,Samara","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",NA,"XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"ERR133843","ERR133843","lineage2.2.1","ru","Russia","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",0,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"ERR158611,0031K-sc-2012-04-10T09:16:39Z-1397823","ERR158611","lineage2.2.1","ru","Russia,Samara","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",1,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"0175R-sc-2011-09-07T13:18:49Z-1276425,ERR067578","ERR067578","lineage2.2.1","ru","Russia,Samara","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",0,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"2385T-sc-2012-10-11T13:38:59Z-1494237,ERR229918","ERR229918","lineage2.2.1","ru","Russia,Samara","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",0,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"1782N-sc-2012-02-21T11:37:25Z-1364785,ERR144548","ERR144548","lineage2.2.1","ru","Russia,Samara","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",0,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"0076J-sc-2012-10-11T13:35:59Z-1494051,ERR234565","ERR234565","lineage2.2.1","ru","Russia,Samara","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",0,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"0773R-sc-2012-02-09T18:57:01Z-1355263,ERR133930","ERR133930","lineage2.2.1","ru","Russia,Samara","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",0,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"2338S-sc-2012-10-11T13:39:04Z-1494242,ERR229923","ERR229923","lineage2.2.1","ru","Russia,Samara","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",1,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"ERR133915,0725P-sc-2012-02-09T18:56:50Z-1355248","ERR133915","lineage2.2.1","ru","Russia,Samara","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",NA,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"ERR1023400","ERR1023400","lineage2.2.1","","","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",0,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"2089X-sc-2012-04-10T09:16:10Z-1397788,ERR158576","ERR158576","lineage2.2.1","ru","Russia,Samara","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",NA,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"ERR067628","ERR067628","lineage2.2.1","ru","Russia","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",0,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"ERR144590,1892H-sc-2012-02-21T11:38:01Z-1364827","ERR144590","lineage2.2.1","ru","Russia,Samara","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",NA,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"ERR067662,0843S-sc-2011-09-07T13:19:38Z-1276509","ERR067662","lineage2.2.1","ru","Russia","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",0,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"0571X-sc-2011-08-25T12:38:49Z-1262364,ERR067765","ERR067765","lineage2.2.1","ru","Russia,Samara","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",1,"XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"ERR137204,1233R-sc-2012-02-21T11:36:23Z-1364696","ERR137204","lineage2.2.1","ru","Russia,Samara","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",0,"XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"ERR158585,2127N-sc-2012-04-10T09:16:18Z-1397797","ERR158585","lineage2.2.1","ru","Russia,Samara","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",NA,"XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"ERR234615,0442G-sc-2012-10-11T13:36:48Z-1494101","ERR234615","lineage2.2.1","ru","Russia","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",0,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"ERR229946,2508C-sc-2012-10-11T13:39:26Z-1494265","ERR229946","lineage2.2.1","ru","Russia,Samara","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",0,"XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"0960V-sc-2011-09-07T13:19:23Z-1276482,ERR067635","ERR067635","lineage2.2.1","ru","Russia,Samara","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",0,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"ERR234609,0638V-sc-2012-10-11T13:36:42Z-1494095","ERR234609","lineage2.2.1","ru","Russia,Samara","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",0,"XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"ERR067718,0157X-sc-2011-08-25T12:38:50Z-1262367","ERR067718","lineage2.2.1","ru","Russia,Samara","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L4","PZA","I","I6",6,"L",0,"MDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage4","other_mutations_pyrazinamide","LEU",0,"MDR_11168","SRR6824330","lineage4.5","cn","China: Luqiao District, Taizhou City, Zhejiang Province","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",NA,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"1810T-sc-2012-02-21T11:37:28Z-1364790,ERR144553","ERR144553","lineage2.2.1","ru","Russia","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",1,"MDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"ERR551494","ERR551494","lineage2.2.1","tm","Turkmenistan","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",0,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"0609N-sc-2012-02-09T18:56:32Z-1355228,ERR133895","ERR133895","lineage2.2.1","ru","Russia,Samara","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",0,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"0818Q-sc-2011-09-07T13:19:32Z-1276498,ERR067651","ERR067651","lineage2.2.1","ru","Russia,Samara","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",NA,"XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"SRR7517822","SRR7517822","lineage2.2.1","ch","Switzerland","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",0,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"ERR158613,0145J-sc-2012-04-10T09:16:40Z-1397825","ERR158613","lineage2.2.1","ru","Russia,Samara","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",0,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"2516L-sc-2012-10-11T13:40:12Z-1494313,ERR229994","ERR229994","lineage2.2.1","ru","Russia,Samara","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",0,"XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"ERR234560,0469L-sc-2012-10-11T13:35:54Z-1494046","ERR234560","lineage2.2.1","ru","Russia,Samara","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",1,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"0259H-sc-2012-02-09T18:55:43Z-1355160,ERR133827","ERR133827","lineage2.2.1","ru","Russia,Samara","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",0,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"1797E-sc-2012-02-21T11:37:25Z-1364786,ERR144549","ERR144549","lineage2.2.1","ru","Russia,Samara","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",0,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"1825K-sc-2012-02-21T11:37:36Z-1364799,ERR144562","ERR144562","lineage2.2.1","ru","Russia,Samara","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",NA,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"1736N-sc-2012-02-21T11:37:09Z-1364764,ERR137272","ERR137272","lineage2.2.1","ru","Russia","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",0,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"ERR067587,0345B-sc-2011-09-07T13:18:54Z-1276434","ERR067587","lineage2.2.1","ru","Russia,Samara","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",0,"XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"ERR234576,0495P-sc-2012-10-11T13:36:09Z-1494062","ERR234576","lineage2.2.1","ru","Russia,Samara","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",0,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"0816N-sc-2011-09-07T13:19:31Z-1276496,ERR067649","ERR067649","lineage2.2.1","ru","Russia,Samara","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",0,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"ERR234623,0462D-sc-2012-10-11T13:36:55Z-1494109","ERR234623","lineage2.2.1","ru","Russia,Samara","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",0,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"0475S-sc-2011-08-25T12:38:43Z-1262353,ERR067754","ERR067754","lineage2.2.1","ru","Russia,Samara","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",0,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"0570W-sc-2012-02-09T18:56:25Z-1355219,ERR133886","ERR133886","lineage2.2.1","ru","Russia,Samara","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",NA,"XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"0391B-sc-2011-09-07T13:19:16Z-1276470,ERR067623","ERR067623","lineage2.2.1","ru","Russia","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",0,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"ERR117470,1346P-sc-2011-10-12T14:59:56Z-1289204","ERR117470","lineage2.2.1","ru","Russia,Samara","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",NA,"XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"ERR133848,0330K-sc-2012-02-09T18:55:57Z-1355181","ERR133848","lineage2.2.1","ru","Russia","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",NA,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"0383S-sc-2011-08-25T12:38:35Z-1262338,ERR067739","ERR067739","lineage2.2.1","ru","Russia","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",0,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"2639V-sc-2012-10-11T13:41:12Z-1494376,ERR234698","ERR234698","lineage2.2.1","ru","Russia,Samara","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",NA,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"ERR108491,1040G-sc-2011-10-12T14:59:22Z-1289156","ERR108491","lineage2.2.1","ru","Russia","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2;L4","PZA","I","I6",6,"L",0,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2;lineage4","other_mutations_pyrazinamide","LEU",0,"2549X-sc-2012-10-11T13:40:42Z-1494344,ERR234666","ERR234666","lineage4;lineage2.2.1","ru","Russia,Samara","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",0,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"ERR228020,2311N-sc-2012-10-11T13:38:07Z-1494184","ERR228020","lineage2.2.1","ru","Russia,Samara","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",NA,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"ERR108454","ERR108454","lineage2.2.1","ru","Russia","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",0,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"ERR027455","ERR027455","lineage2.2.1","ru","Russia","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",0,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"ERR108489,1030W-sc-2011-10-12T14:59:20Z-1289154","ERR108489","lineage2.2.1","ru","Russia,Samara","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",0,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"ERR228064,2215J-sc-2012-10-11T13:38:50Z-1494228","ERR228064","lineage2.2.1","ru","Russia,Samara","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",0,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"2135X-sc-2012-04-10T09:16:22Z-1397802,ERR158590","ERR158590","lineage2.2.1","ru","Russia,Samara","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",0,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"ERR229924,2352H-sc-2012-10-11T13:39:05Z-1494243","ERR229924","lineage2.2.1","ru","Russia,Samara","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",NA,"XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"0481Z-sc-2012-10-11T13:36:01Z-1494054,ERR234568","ERR234568","lineage2.2.1","ru","Russia","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",0,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"ERR144597,1917K-sc-2012-02-21T11:38:05Z-1364834","ERR144597","lineage2.2.1","ru","Russia,Samara","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",NA,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"0833G-sc-2011-09-07T13:19:34Z-1276501,ERR067654","ERR067654","lineage2.2.1","ru","Russia,Samara","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2;L4","PZA","I","I6",6,"L",0,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2;lineage4","other_mutations_pyrazinamide","LEU",0,"ERR234570,0658R-sc-2012-10-11T13:36:03Z-1494056","ERR234570","lineage4;lineage2.2.1","ru","Russia,Samara","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",0,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"0666A-sc-2012-10-11T13:36:50Z-1494104,ERR234618","ERR234618","lineage2.2.1","ru","Russia,Samara","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",0,"XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"1921P-sc-2012-02-21T11:38:08Z-1364837,ERR144600","ERR144600","lineage2.2.1","ru","Russia,Samara","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",0,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"2072D-sc-2012-02-21T11:38:30Z-1364870,ERR144632","ERR144632","lineage2.2.1","ru","Russia,Samara","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",0,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"ERR067663,0844T-sc-2011-09-07T13:19:39Z-1276510","ERR067663","lineage2.2.1","ru","Russia,Samara","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",0,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"1366L-sc-2012-02-21T11:36:34Z-1364712,ERR137220","ERR137220","lineage2.2.1","ru","Russia,Samara","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",0,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"ERR228019,2287M-sc-2012-10-11T13:38:07Z-1494183","ERR228019","lineage2.2.1","ru","Russia,Samara","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",NA,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"2369B-sc-2012-10-11T13:39:13Z-1494252,ERR229933","ERR229933","lineage2.2.1","ru","Russia","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",NA,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"2249W-sc-2012-10-11T13:37:27Z-1494142,ERR227978","ERR227978","lineage2.2.1","ru","Russia","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",0,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"ERR133953,0826Z-sc-2012-02-09T18:57:18Z-1355286","ERR133953","lineage2.2.1","ru","Russia,Samara","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",NA,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"ERR158597,2152Q-sc-2012-04-10T09:16:26Z-1397809","ERR158597","lineage2.2.1","ru","Russia","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",NA,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"ETB0088","SRR6257030","lineage2.2.1","ru","Russia:Samara","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",0,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"1705E-sc-2012-02-21T11:37:02Z-1364754,ERR137262","ERR137262","lineage2.2.1","ru","Russia,Samara","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",0,"XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"ERR067704,1467W-sc-2011-09-07T13:20:04Z-1276551","ERR067704","lineage2.2.1","ru","Russia,Samara","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",0,"XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"ERR144611,2011M-sc-2012-02-21T11:38:15Z-1364848","ERR144611","lineage2.2.1","ru","Russia,Samara","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",NA,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"ERR228054","ERR228054","lineage2.2.1","ru","Russia","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",NA,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"SAMN02414916","SRR1146417_SRR1162881_SRR1163087_SRR1144810","lineage2.2.1","se","Sweden","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",0,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"1596L-sc-2011-10-12T14:58:40Z-1289101,ERR108436","ERR108436","lineage2.2.1","ru","Russia,Samara","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",NA,"XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"0187E-sc-2011-08-25T12:38:22Z-1262319,ERR067720","ERR067720","lineage2.2.1","ru","Russia","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",NA,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"ERR027458","ERR027458","lineage2.2.1","ru","Russia","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",0,"XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"ERR229960,2484B-sc-2012-10-11T13:39:39Z-1494279","ERR229960","lineage2.2.1","ru","Russia,Samara","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",0,"XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"ERR227996,2308K-sc-2012-10-11T13:37:45Z-1494160","ERR227996","lineage2.2.1","ru","Russia,Samara","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",0,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"ERR133806,0126N-sc-2012-02-09T18:55:27Z-1355139","ERR133806","lineage2.2.1","ru","Russia,Samara","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L4","PZA","I","I6",6,"L",NA,"MDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage4","other_mutations_pyrazinamide","LEU",0,"ERR2179654","ERR2179654","lineage4.5","cn","China","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",NA,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"ERR108484,1002Q-sc-2011-10-12T14:59:16Z-1289149","ERR108484","lineage2.2.1","ru","Russia","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",NA,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"ERR229980,2362T-sc-2012-10-11T13:39:58Z-1494299","ERR229980","lineage2.2.1","ru","Russia","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",0,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"0928K-sc-2011-10-12T14:59:49Z-1289194,ERR117460","ERR117460","lineage2.2.1","ru","Russia,Samara","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",0,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"ERR137281,1755J-sc-2012-02-21T11:37:17Z-1364773","ERR137281","lineage2.2.1","ru","Russia,Samara","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",0,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"ERR158586,2128P-sc-2012-04-10T09:16:18Z-1397798","ERR158586","lineage2.2.1","ru","Russia,Samara","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",NA,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"ERR067741,0386W-sc-2011-08-25T12:38:36Z-1262340","ERR067741","lineage2.2.1","ru","Russia","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",0,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"ERR067762,0512H-sc-2011-08-25T12:38:47Z-1262361","ERR067762","lineage2.2.1","ru","Russia,Samara","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",0,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"ERR133826,0255D-sc-2012-02-09T18:55:42Z-1355159","ERR133826","lineage2.2.1","ru","Russia,Samara","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",0,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"1559W-sc-2011-09-07T13:20:10Z-1276562,ERR067715","ERR067715","lineage2.2.1","ru","Russia,Samara","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L4","PZA","I","I6",6,"L",NA,"MDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage4","other_mutations_pyrazinamide","LEU",0,"SRS797396","SRR1723935","lineage4.5","cn","China:Zhejiang","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",0,"XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"ERR234633,0647E-sc-2012-10-11T13:37:05Z-1494119","ERR234633","lineage2.2.1","ru","Russia,Samara","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",1,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"0338T-sc-2012-10-11T13:36:54Z-1494108,ERR234622","ERR234622","lineage2.2.1","ru","Russia,Samara","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",0,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"ERR133889,0590S-sc-2012-02-09T18:56:26Z-1355222","ERR133889","lineage2.2.1","ru","Russia,Samara","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",0,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"ERR067583,0217M-sc-2011-09-07T13:18:51Z-1276430","ERR067583","lineage2.2.1","ru","Russia,Samara","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",0,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"0897B-sc-2011-10-12T14:58:57Z-1289123,ERR108458","ERR108458","lineage2.2.1","ru","Russia,Samara","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",0,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"1271H-sc-2012-02-21T11:36:28Z-1364702,ERR137210","ERR137210","lineage2.2.1","ru","Russia,Samara","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",0,"XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"ERR234641,0649G-sc-2012-10-11T13:37:13Z-1494127","ERR234641","lineage2.2.1","ru","Russia,Samara","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",NA,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"1474D-sc-2011-09-07T13:20:08Z-1276557,ERR067710","ERR067710","lineage2.2.1","ru","Russia","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",0,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"1860Y-sc-2012-02-21T11:37:46Z-1364812,ERR144575","ERR144575","lineage2.2.1","ru","Russia,Samara","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",0,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"ERR067656,0835J-sc-2011-09-07T13:19:35Z-1276503","ERR067656","lineage2.2.1","ru","Russia,Samara","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",1,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"ETB0040","SRR6257082","lineage2.2.1","ru","Russia:Samara","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",0,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"ERR019564","ERR019564","lineage2.2.1","ru","Russia","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",NA,"XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"0312Q-sc-2012-02-09T18:55:55Z-1355178,ERR133845","ERR133845","lineage2.2.1","ru","Russia","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",0,"XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"ERR144593,1901S-sc-2012-02-21T11:38:03Z-1364830","ERR144593","lineage2.2.1","ru","Russia,Samara","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",0,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"0273Y-sc-2012-02-09T18:55:45Z-1355164,ERR133831","ERR133831","lineage2.2.1","ru","Russia,Samara","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",0,"XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"ERR144543,1770A-sc-2012-02-21T11:37:22Z-1364780","ERR144543","lineage2.2.1","ru","Russia,Samara","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",0,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"ERR137283,1765V-sc-2012-02-21T11:37:18Z-1364775","ERR137283","lineage2.2.1","ru","Russia,Samara","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",0,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"ERR019559","ERR019559","lineage2.2.1","ru","Russia","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",0,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"0163D-sc-2011-09-07T13:18:46Z-1276423,ERR067576","ERR067576","lineage2.2.1","ru","Russia,Samara","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",0,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"ERR067620,0053J-sc-2011-09-07T13:19:14Z-1276467","ERR067620","lineage2.2.1","ru","Russia,Samara","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",0,"XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"ERR229962,2512G-sc-2012-10-11T13:39:41Z-1494281","ERR229962","lineage2.2.1","ru","Russia,Samara","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",0,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"0817P-sc-2011-09-07T13:19:31Z-1276497,ERR067650","ERR067650","lineage2.2.1","ru","Russia,Samara","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",0,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"ERR234574,0283J-sc-2012-10-11T13:36:07Z-1494060","ERR234574","lineage2.2.1","ru","Russia,Samara","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",0,"XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"ERR234590,0292T-sc-2012-10-11T13:36:23Z-1494076","ERR234590","lineage2.2.1","ru","Russia,Samara","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",0,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"ERR067613,0628J-sc-2011-09-07T13:19:09Z-1276460","ERR067613","lineage2.2.1","ru","Russia,Samara","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",NA,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"ERR133853,0388Y-sc-2012-02-09T18:56:01Z-1355186","ERR133853","lineage2.2.1","ru","Russia","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",0,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"1475E-sc-2011-09-07T13:20:08Z-1276558,ERR067711","ERR067711","lineage2.2.1","ru","Russia,Samara","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",NA,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"ERR067652,0828B-sc-2011-09-07T13:19:33Z-1276499","ERR067652","lineage2.2.1","ru","Russia","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",0,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"ERR234660,2535G-sc-2012-10-11T13:40:36Z-1494338","ERR234660","lineage2.2.1","ru","Russia,Samara","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",0,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"1432H-sc-2012-02-21T11:36:41Z-1364722,ERR137230","ERR137230","lineage2.2.1","ru","Russia,Samara","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",0,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"0071D-sc-2011-10-12T14:59:29Z-1289167,ERR108502","ERR108502","lineage2.2.1","ru","Russia,Samara","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",NA,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"2281F-sc-2012-10-11T13:37:44Z-1494159,ERR227995","ERR227995","lineage2.2.1","ru","Russia","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",NA,"XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"ERR229916,2351G-sc-2012-10-11T13:38:57Z-1494235","ERR229916","lineage2.2.1","ru","Russia","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",0,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"2052G-sc-2012-02-21T11:38:26Z-1364865,ERR144628","ERR144628","lineage2.2.1","ru","Russia,Samara","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",NA,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"0052H-sc-2012-10-11T13:37:00Z-1494114,ERR234628","ERR234628","lineage2.2.1","ru","Russia","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",0,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"ERR133944,0799V-sc-2012-02-09T18:57:11Z-1355277","ERR133944","lineage2.2.1","ru","Russia,Samara","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",NA,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"ERR137211,1284X-sc-2012-02-21T11:36:28Z-1364703","ERR137211","lineage2.2.1","ru","Russia","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",0,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"ERR137222,1391N-sc-2012-02-21T11:36:35Z-1364714","ERR137222","lineage2.2.1","ru","Russia,Samara","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",0,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"ERR137269,1731H-sc-2012-02-21T11:37:07Z-1364761","ERR137269","lineage2.2.1","ru","Russia,Samara","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",0,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"ERR133868,0484C-sc-2012-02-09T18:56:12Z-1355201","ERR133868","lineage2.2.1","ru","Russia,Samara","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",0,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"1741T-sc-2012-02-21T11:37:13Z-1364769,ERR137277","ERR137277","lineage2.2.1","ru","Russia,Samara","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",0,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"2053H-sc-2012-10-11T13:38:32Z-1494210,ERR228046","ERR228046","lineage2.2.1","ru","Russia,Samara","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",0,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"0978P-sc-2011-10-12T14:59:09Z-1289140,ERR108475","ERR108475","lineage2.2.1","ru","Russia,Samara","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6L","L2","PZA","I","I6",6,"L",NA,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.018,-0.548,0.267883,-1.616,-0.58,5,53,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0097024579560155,0.385310257492613,0.385311080310026,0.385326683377145,8.35414540919546,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-2,-5,2,0,-2,-2,-0.764437689969605,-0.141602067183462,0.00975688197029407,-0.275532821824382,-0.151832460732984,0.0526315789473684,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",-0.953704270146009,0.0037560422096937,0.329095586242593,-2.89795521427317,0.189089468462042,0.697385389891155,-0.414189429312607,0.0017355697972772,2.76055791615401,0.180049643960023,0.733980750878148,0.0038480840706912,"lineage2","other_mutations_pyrazinamide","LEU",0,"ERR019575","ERR019575","lineage2.2.1","ru","Russia","pnca_p.ile6leu","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6M","L4","PZA","I","I6",6,"M",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-3.085,-1.021,0.24349,-2.364,0.14,10,59,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,NA,NA,NA,NA,NA,-32,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-3,0,0,-3,-2,0,-4,-2,-0.781408308004053,-0.263824289405685,0.00886843581319794,-0.40306905370844,0.0786516853932584,0.105263157894737,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage4","dr_mutations_pyrazinamide","MET",0,"ERR1555057","ERR1555057","lineage4.3.3","","","pnca_p.ile6met","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6S","L2","PZA","I","I6",6,"S",1,"Pre-XDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",9.258,-1.047,-3.585,6.01751,-4.149,-3.42,64,80,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0001437401178668,19.411022297013,511754.463552573,Inf,4.73122070382274,24,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,-1,0,-1,0,2,0,4,0,-0.265197568389058,-0.926356589147287,0.219170812724452,-0.707416879795396,-0.895287958115183,0.673684210526316,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",13.1456002256205,0.924803768446996,139.277183326562,0.094384449136928,0.0001628371344453,NA,1.28804840845689,0.0292235860951597,1.53426649183163,0.91081598550184,Inf,0.0296198560706035,"lineage2","dr_mutations_pyrazinamide","SER",0,"ERR2516977","ERR2516977","lineage2.2.1","gb","UK","pnca_p.ile6ser","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6S","L2","PZA","I","I6",6,"S",1,"Pre-XDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",9.258,-1.047,-3.585,6.01751,-4.149,-3.42,64,80,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.0001437401178668,19.411022297013,511754.463552573,Inf,4.73122070382274,24,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,-1,0,-1,0,2,0,4,0,-0.265197568389058,-0.926356589147287,0.219170812724452,-0.707416879795396,-0.895287958115183,0.673684210526316,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",13.1456002256205,0.924803768446996,139.277183326562,0.094384449136928,0.0001628371344453,NA,1.28804840845689,0.0292235860951597,1.53426649183163,0.91081598550184,Inf,0.0296198560706035,"lineage2","dr_mutations_pyrazinamide","SER",0,"ERR2516895","ERR2516895","lineage2.2.1","gb","UK","pnca_p.ile6ser","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6T","L2","PZA","I","I6",6,"T",1,"XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",9.258,-1.244,-3.089,3.71452,-3.589,-3.14,62,80,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.000646830530401,87.6075949367089,1395214.80217275,Inf,38.0099632572142,24,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,-1,0,-1,0,2,0,0,0,-0.315096251266464,-0.798191214470284,0.135290903925582,-0.611935208866155,-0.821989528795812,0.652631578947368,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",14.148558941436,0.896008552350165,108.247901039825,0.130705157379733,226.474535586036,NA,1.94254175795031,1.23317897951184e-07,6.90897388676731,9.59561062779463,Inf,7.038428913028e-10,"lineage2","dr_mutations_pyrazinamide","THR",0,"ERR2510686","ERR2510686","lineage2.2.1","it","Italy","pnca_p.ile6thr","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6T","L1","PZA","I","I6",6,"T",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",9.258,-1.244,-3.089,3.71452,-3.589,-3.14,62,80,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.000646830530401,87.6075949367089,1395214.80217275,Inf,38.0099632572142,24,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,-1,0,-1,0,2,0,0,0,-0.315096251266464,-0.798191214470284,0.135290903925582,-0.611935208866155,-0.821989528795812,0.652631578947368,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",14.148558941436,0.896008552350165,108.247901039825,0.130705157379733,226.474535586036,NA,1.94254175795031,1.23317897951184e-07,6.90897388676731,9.59561062779463,Inf,7.038428913028e-10,"lineage1","dr_mutations_pyrazinamide","THR",0,"SAMN02414908","SRR1163076_SRR1144791_SRR1163465_SRR1146277","lineage1.1.2","se","Sweden","pnca_p.ile6thr","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6T","L4","PZA","I","I6",6,"T",1,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",9.258,-1.244,-3.089,3.71452,-3.589,-3.14,62,80,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.000646830530401,87.6075949367089,1395214.80217275,Inf,38.0099632572142,24,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,-1,0,-1,0,2,0,0,0,-0.315096251266464,-0.798191214470284,0.135290903925582,-0.611935208866155,-0.821989528795812,0.652631578947368,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",14.148558941436,0.896008552350165,108.247901039825,0.130705157379733,226.474535586036,NA,1.94254175795031,1.23317897951184e-07,6.90897388676731,9.59561062779463,Inf,7.038428913028e-10,"lineage4","dr_mutations_pyrazinamide","THR",0,"ERR2510434","ERR2510434","lineage4.9","pk","Pakistan","pnca_p.ile6thr","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6T","L2","PZA","I","I6",6,"T",1,"XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",9.258,-1.244,-3.089,3.71452,-3.589,-3.14,62,80,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.000646830530401,87.6075949367089,1395214.80217275,Inf,38.0099632572142,24,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,-1,0,-1,0,2,0,0,0,-0.315096251266464,-0.798191214470284,0.135290903925582,-0.611935208866155,-0.821989528795812,0.652631578947368,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",14.148558941436,0.896008552350165,108.247901039825,0.130705157379733,226.474535586036,NA,1.94254175795031,1.23317897951184e-07,6.90897388676731,9.59561062779463,Inf,7.038428913028e-10,"lineage2","dr_mutations_pyrazinamide","THR",0,"ERR2510710","ERR2510710","lineage2.2.1","it","Italy","pnca_p.ile6thr","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6T","L2","PZA","I","I6",6,"T",1,"XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",9.258,-1.244,-3.089,3.71452,-3.589,-3.14,62,80,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.000646830530401,87.6075949367089,1395214.80217275,Inf,38.0099632572142,24,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,-1,0,-1,0,2,0,0,0,-0.315096251266464,-0.798191214470284,0.135290903925582,-0.611935208866155,-0.821989528795812,0.652631578947368,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",14.148558941436,0.896008552350165,108.247901039825,0.130705157379733,226.474535586036,NA,1.94254175795031,1.23317897951184e-07,6.90897388676731,9.59561062779463,Inf,7.038428913028e-10,"lineage2","dr_mutations_pyrazinamide","THR",0,"ERR2510690","ERR2510690","lineage2.2.1","it","Italy","pnca_p.ile6thr","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6T","L2","PZA","I","I6",6,"T",1,"XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",9.258,-1.244,-3.089,3.71452,-3.589,-3.14,62,80,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.000646830530401,87.6075949367089,1395214.80217275,Inf,38.0099632572142,24,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,-1,0,-1,0,2,0,0,0,-0.315096251266464,-0.798191214470284,0.135290903925582,-0.611935208866155,-0.821989528795812,0.652631578947368,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",14.148558941436,0.896008552350165,108.247901039825,0.130705157379733,226.474535586036,NA,1.94254175795031,1.23317897951184e-07,6.90897388676731,9.59561062779463,Inf,7.038428913028e-10,"lineage2","dr_mutations_pyrazinamide","THR",0,"ERR2510703","ERR2510703","lineage2.2.1","it","Italy","pnca_p.ile6thr","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6T","L2","PZA","I","I6",6,"T",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",9.258,-1.244,-3.089,3.71452,-3.589,-3.14,62,80,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.000646830530401,87.6075949367089,1395214.80217275,Inf,38.0099632572142,24,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,-1,0,-1,0,2,0,0,0,-0.315096251266464,-0.798191214470284,0.135290903925582,-0.611935208866155,-0.821989528795812,0.652631578947368,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",14.148558941436,0.896008552350165,108.247901039825,0.130705157379733,226.474535586036,NA,1.94254175795031,1.23317897951184e-07,6.90897388676731,9.59561062779463,Inf,7.038428913028e-10,"lineage2","dr_mutations_pyrazinamide","THR",0,"SAMN02414851","SRR1162709_SRR1166864_SRR1165553_SRR1165535","lineage2.2.1","se","Sweden","pnca_p.ile6thr","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6T","L2","PZA","I","I6",6,"T",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",9.258,-1.244,-3.089,3.71452,-3.589,-3.14,62,80,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.000646830530401,87.6075949367089,1395214.80217275,Inf,38.0099632572142,24,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,-1,0,-1,0,2,0,0,0,-0.315096251266464,-0.798191214470284,0.135290903925582,-0.611935208866155,-0.821989528795812,0.652631578947368,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",14.148558941436,0.896008552350165,108.247901039825,0.130705157379733,226.474535586036,NA,1.94254175795031,1.23317897951184e-07,6.90897388676731,9.59561062779463,Inf,7.038428913028e-10,"lineage2","dr_mutations_pyrazinamide","THR",0,"SAMN02414859","SRR1165540_SRR1165563_SRR1162741_SRR1166932","lineage2.2.1","se","Sweden","pnca_p.ile6thr","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6T","L2","PZA","I","I6",6,"T",1,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",9.258,-1.244,-3.089,3.71452,-3.589,-3.14,62,80,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.000646830530401,87.6075949367089,1395214.80217275,Inf,38.0099632572142,24,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,-1,0,-1,0,2,0,0,0,-0.315096251266464,-0.798191214470284,0.135290903925582,-0.611935208866155,-0.821989528795812,0.652631578947368,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",14.148558941436,0.896008552350165,108.247901039825,0.130705157379733,226.474535586036,NA,1.94254175795031,1.23317897951184e-07,6.90897388676731,9.59561062779463,Inf,7.038428913028e-10,"lineage2","dr_mutations_pyrazinamide","THR",0,"1530P-sc-2011-10-12T14:58:51Z-1289115,ERR108450","ERR108450","lineage2.2.1","ru","Russia,Samara","pnca_p.ile6thr","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6T","L2","PZA","I","I6",6,"T",1,"XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",9.258,-1.244,-3.089,3.71452,-3.589,-3.14,62,80,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.000646830530401,87.6075949367089,1395214.80217275,Inf,38.0099632572142,24,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,-1,0,-1,0,2,0,0,0,-0.315096251266464,-0.798191214470284,0.135290903925582,-0.611935208866155,-0.821989528795812,0.652631578947368,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",14.148558941436,0.896008552350165,108.247901039825,0.130705157379733,226.474535586036,NA,1.94254175795031,1.23317897951184e-07,6.90897388676731,9.59561062779463,Inf,7.038428913028e-10,"lineage2","dr_mutations_pyrazinamide","THR",0,"ERR2510723","ERR2510723","lineage2.2.1","it","Italy","pnca_p.ile6thr","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6T","L2","PZA","I","I6",6,"T",1,"XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",9.258,-1.244,-3.089,3.71452,-3.589,-3.14,62,80,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.000646830530401,87.6075949367089,1395214.80217275,Inf,38.0099632572142,24,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,-1,0,-1,0,2,0,0,0,-0.315096251266464,-0.798191214470284,0.135290903925582,-0.611935208866155,-0.821989528795812,0.652631578947368,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",14.148558941436,0.896008552350165,108.247901039825,0.130705157379733,226.474535586036,NA,1.94254175795031,1.23317897951184e-07,6.90897388676731,9.59561062779463,Inf,7.038428913028e-10,"lineage2","dr_mutations_pyrazinamide","THR",0,"ERR2510709","ERR2510709","lineage2.2.1","it","Italy","pnca_p.ile6thr","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6T","L2","PZA","I","I6",6,"T",1,"XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",9.258,-1.244,-3.089,3.71452,-3.589,-3.14,62,80,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,0.000646830530401,87.6075949367089,1395214.80217275,Inf,38.0099632572142,24,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,-1,0,-1,0,2,0,0,0,-0.315096251266464,-0.798191214470284,0.135290903925582,-0.611935208866155,-0.821989528795812,0.652631578947368,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",14.148558941436,0.896008552350165,108.247901039825,0.130705157379733,226.474535586036,NA,1.94254175795031,1.23317897951184e-07,6.90897388676731,9.59561062779463,Inf,7.038428913028e-10,"lineage2","dr_mutations_pyrazinamide","THR",0,"ERR2510702","ERR2510702","lineage2.2.1","it","Italy","pnca_p.ile6thr","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6V","L1","PZA","I","I6",6,"V",NA,"Sensitive","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-2.761,-1.528,1.33147,-1.511,-1.35,-86,93,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,NA,NA,NA,NA,NA,24,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-1,0,-1,0,2,0,2,0,-0.699341438703141,-0.394832041343669,0.048495035657311,-0.257630008525149,-0.353403141361257,-0.924731182795699,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","neutral",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage1","other_mutations_pyrazinamide","VAL",0,"SAMN02599161","SRR1173036_SRR1172709","lineage1.1.3","in","India","pnca_p.ile6val","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6V","","PZA","I","I6",6,"V",NA,"Other","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-2.761,-1.528,1.33147,-1.511,-1.35,-86,93,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,NA,NA,NA,NA,NA,24,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-1,0,-1,0,2,0,2,0,-0.699341438703141,-0.394832041343669,0.048495035657311,-0.257630008525149,-0.353403141361257,-0.924731182795699,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","neutral",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"","other_mutations_pyrazinamide","VAL",0,"SRR7496471","SRR7496471","","us","Hawaii","pnca_p.ile6val","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"I6V","L4","PZA","I","I6",6,"V",NA,"Pre-MDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.258,-2.761,-1.528,1.33147,-1.511,-1.35,-86,93,-0.6,7,7,1,0.0050761421319796,"strand",4.4,11.36,NA,NA,NA,NA,NA,24,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-1,0,-1,0,2,0,2,0,-0.699341438703141,-0.394832041343669,0.048495035657311,-0.257630008525149,-0.353403141361257,-0.924731182795699,-0.494233937397035,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","neutral",-0.728,-0.553,"8:7","146/150","M:A:I:L:V",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage4","other_mutations_pyrazinamide","VAL",0,"SRR7496523","SRR7496523","lineage4","us","Hawaii","pnca_p.ile6val","A","E","ILE","IA6","pnca_complex.pdb"
|
|
"V7A","L4","PZA","V","V7",7,"A",NA,"Other","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",5.336,-0.97,-2.592,3.42668,-3.043,-1.9,64,80,-0.66,7,7,0,0,"strand",1.73333333333333,11.02,7.18700589334483e-05,2.42412778478352,0.0001249735077034,0,1.03410070803344e-29,2,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,5,0,3,2,4,0,6,3,-0.245694022289767,-0.669767441860465,0.124807144574188,-0.518840579710145,-0.49738219895288,0.673684210526316,-0.543657331136738,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.779,-0.615,"8:7","146/150","V:I:A",-8.98740878149641,0.940032862253633,119.468044435491,-0.075228558598775,NA,4692673.51081185,0.384555509373631,1,0,0,188.544222231268,0.999999999999997,"lineage4","other_mutations_pyrazinamide","ALA",0,"ERR2229336","ERR2229336","lineage4.8","dk","","pnca_p.val7ala","A","E","VAL","VA7","pnca_complex.pdb"
|
|
"V7A","L2","PZA","V","V7",7,"A",NA,"XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",5.336,-0.97,-2.592,3.42668,-3.043,-1.9,64,80,-0.66,7,7,0,0,"strand",1.73333333333333,11.02,7.18700589334483e-05,2.42412778478352,0.0001249735077034,0,1.03410070803344e-29,2,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,5,0,3,2,4,0,6,3,-0.245694022289767,-0.669767441860465,0.124807144574188,-0.518840579710145,-0.49738219895288,0.673684210526316,-0.543657331136738,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.779,-0.615,"8:7","146/150","V:I:A",-8.98740878149641,0.940032862253633,119.468044435491,-0.075228558598775,NA,4692673.51081185,0.384555509373631,1,0,0,188.544222231268,0.999999999999997,"lineage2","other_mutations_pyrazinamide","ALA",0,"SRR5266560","SRR5266560","lineage2.2.1","ru","Russia","pnca_p.val7ala","A","E","VAL","VA7","pnca_complex.pdb"
|
|
"V7A","L2","PZA","V","V7",7,"A",NA,"XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",5.336,-0.97,-2.592,3.42668,-3.043,-1.9,64,80,-0.66,7,7,0,0,"strand",1.73333333333333,11.02,7.18700589334483e-05,2.42412778478352,0.0001249735077034,0,1.03410070803344e-29,2,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,5,0,3,2,4,0,6,3,-0.245694022289767,-0.669767441860465,0.124807144574188,-0.518840579710145,-0.49738219895288,0.673684210526316,-0.543657331136738,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.779,-0.615,"8:7","146/150","V:I:A",-8.98740878149641,0.940032862253633,119.468044435491,-0.075228558598775,NA,4692673.51081185,0.384555509373631,1,0,0,188.544222231268,0.999999999999997,"lineage2","other_mutations_pyrazinamide","ALA",0,"ETB0089","SRR6257033","lineage2.2.1","ru","Russia:Leningrad Region","pnca_p.val7ala","A","E","VAL","VA7","pnca_complex.pdb"
|
|
"V7A","L2","PZA","V","V7",7,"A",NA,"XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",5.336,-0.97,-2.592,3.42668,-3.043,-1.9,64,80,-0.66,7,7,0,0,"strand",1.73333333333333,11.02,7.18700589334483e-05,2.42412778478352,0.0001249735077034,0,1.03410070803344e-29,2,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,5,0,3,2,4,0,6,3,-0.245694022289767,-0.669767441860465,0.124807144574188,-0.518840579710145,-0.49738219895288,0.673684210526316,-0.543657331136738,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.779,-0.615,"8:7","146/150","V:I:A",-8.98740878149641,0.940032862253633,119.468044435491,-0.075228558598775,NA,4692673.51081185,0.384555509373631,1,0,0,188.544222231268,0.999999999999997,"lineage2","other_mutations_pyrazinamide","ALA",0,"SRR5266539","SRR5266539","lineage2.2.1","ru","Russia","pnca_p.val7ala","A","E","VAL","VA7","pnca_complex.pdb"
|
|
"V7A","L2","PZA","V","V7",7,"A",NA,"MDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",5.336,-0.97,-2.592,3.42668,-3.043,-1.9,64,80,-0.66,7,7,0,0,"strand",1.73333333333333,11.02,7.18700589334483e-05,2.42412778478352,0.0001249735077034,0,1.03410070803344e-29,2,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,5,0,3,2,4,0,6,3,-0.245694022289767,-0.669767441860465,0.124807144574188,-0.518840579710145,-0.49738219895288,0.673684210526316,-0.543657331136738,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.779,-0.615,"8:7","146/150","V:I:A",-8.98740878149641,0.940032862253633,119.468044435491,-0.075228558598775,NA,4692673.51081185,0.384555509373631,1,0,0,188.544222231268,0.999999999999997,"lineage2","other_mutations_pyrazinamide","ALA",0,"ERR2516416","ERR2516416","lineage2.2.1.1","nl","Netherlands","pnca_p.val7ala","A","E","VAL","VA7","pnca_complex.pdb"
|
|
"V7A","L4","PZA","V","V7",7,"A",NA,"MDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",5.336,-0.97,-2.592,3.42668,-3.043,-1.9,64,80,-0.66,7,7,0,0,"strand",1.73333333333333,11.02,7.18700589334483e-05,2.42412778478352,0.0001249735077034,0,1.03410070803344e-29,2,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,5,0,3,2,4,0,6,3,-0.245694022289767,-0.669767441860465,0.124807144574188,-0.518840579710145,-0.49738219895288,0.673684210526316,-0.543657331136738,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.779,-0.615,"8:7","146/150","V:I:A",-8.98740878149641,0.940032862253633,119.468044435491,-0.075228558598775,NA,4692673.51081185,0.384555509373631,1,0,0,188.544222231268,0.999999999999997,"lineage4","other_mutations_pyrazinamide","ALA",0,"ERR2707207","ERR2707207","lineage4.3.4.2","cd","Democratic Republic of Congo","pnca_p.val7ala","A","E","VAL","VA7","pnca_complex.pdb"
|
|
"V7A","L4","PZA","V","V7",7,"A",NA,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",5.336,-0.97,-2.592,3.42668,-3.043,-1.9,64,80,-0.66,7,7,0,0,"strand",1.73333333333333,11.02,7.18700589334483e-05,2.42412778478352,0.0001249735077034,0,1.03410070803344e-29,2,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,5,0,3,2,4,0,6,3,-0.245694022289767,-0.669767441860465,0.124807144574188,-0.518840579710145,-0.49738219895288,0.673684210526316,-0.543657331136738,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.779,-0.615,"8:7","146/150","V:I:A",-8.98740878149641,0.940032862253633,119.468044435491,-0.075228558598775,NA,4692673.51081185,0.384555509373631,1,0,0,188.544222231268,0.999999999999997,"lineage4","other_mutations_pyrazinamide","ALA",0,"SAMN02403510","SRR1167309_SRR1173718_SRR1165298_SRR1173815","lineage4.1.1.3","za","South Africa","pnca_p.val7ala","A","E","VAL","VA7","pnca_complex.pdb"
|
|
"V7A","L2","PZA","V","V7",7,"A",0,"MDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",5.336,-0.97,-2.592,3.42668,-3.043,-1.9,64,80,-0.66,7,7,0,0,"strand",1.73333333333333,11.02,7.18700589334483e-05,2.42412778478352,0.0001249735077034,0,1.03410070803344e-29,2,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,5,0,3,2,4,0,6,3,-0.245694022289767,-0.669767441860465,0.124807144574188,-0.518840579710145,-0.49738219895288,0.673684210526316,-0.543657331136738,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.779,-0.615,"8:7","146/150","V:I:A",-8.98740878149641,0.940032862253633,119.468044435491,-0.075228558598775,NA,4692673.51081185,0.384555509373631,1,0,0,188.544222231268,0.999999999999997,"lineage2","other_mutations_pyrazinamide","ALA",0,"ERR2516577","ERR2516577","lineage2.2.1.1","nl","Netherlands","pnca_p.val7ala","A","E","VAL","VA7","pnca_complex.pdb"
|
|
"V7F","L2","PZA","V","V7",7,"F",1,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",5.336,0.042,-1.877,4.86315,-2.949,-1.55,83,91,-0.66,7,7,0,0,"strand",1.73333333333333,11.02,0.0002156101768003,9.70466975178797,9.70465898653049,9.70194990589383,2.29168245016684,-54,-2,0,0,-2,0,0,0,0,0,0,-2,0,0,0,0,0,-3,0,1,-4,-8,0,-6,-4,0.0188340807174887,-0.485012919896641,0.177126508788671,-0.502813299232737,-0.405759162303665,0.873684210526316,-0.543657331136738,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.779,-0.615,"8:7","146/150","V:I:A",2.27260607808817,0.06344559022609,1.22442760158496,1.8560559033024,0.929172866365903,208.881603004777,0.986980761010679,0.0776844925942494,1.10966566656461,0.504888890842109,570.372842410328,0.130068862702538,"lineage2","dr_mutations_pyrazinamide","PHE",0,"ERR2510561","ERR2510561","lineage2.2.1","pk","Pakistan","pnca_p.val7phe","A","E","VAL","VA7","pnca_complex.pdb"
|
|
"V7F","L4","PZA","V","V7",7,"F",0,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",5.336,0.042,-1.877,4.86315,-2.949,-1.55,83,91,-0.66,7,7,0,0,"strand",1.73333333333333,11.02,0.0002156101768003,9.70466975178797,9.70465898653049,9.70194990589383,2.29168245016684,-54,-2,0,0,-2,0,0,0,0,0,0,-2,0,0,0,0,0,-3,0,1,-4,-8,0,-6,-4,0.0188340807174887,-0.485012919896641,0.177126508788671,-0.502813299232737,-0.405759162303665,0.873684210526316,-0.543657331136738,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.779,-0.615,"8:7","146/150","V:I:A",2.27260607808817,0.06344559022609,1.22442760158496,1.8560559033024,0.929172866365903,208.881603004777,0.986980761010679,0.0776844925942494,1.10966566656461,0.504888890842109,570.372842410328,0.130068862702538,"lineage4","dr_mutations_pyrazinamide","PHE",0,"ERR2510453","ERR2510453","lineage4.8","pk","Pakistan","pnca_p.val7phe","A","E","VAL","VA7","pnca_complex.pdb"
|
|
"V7F","L2","PZA","V","V7",7,"F",NA,"XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",5.336,0.042,-1.877,4.86315,-2.949,-1.55,83,91,-0.66,7,7,0,0,"strand",1.73333333333333,11.02,0.0002156101768003,9.70466975178797,9.70465898653049,9.70194990589383,2.29168245016684,-54,-2,0,0,-2,0,0,0,0,0,0,-2,0,0,0,0,0,-3,0,1,-4,-8,0,-6,-4,0.0188340807174887,-0.485012919896641,0.177126508788671,-0.502813299232737,-0.405759162303665,0.873684210526316,-0.543657331136738,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.779,-0.615,"8:7","146/150","V:I:A",2.27260607808817,0.06344559022609,1.22442760158496,1.8560559033024,0.929172866365903,208.881603004777,0.986980761010679,0.0776844925942494,1.10966566656461,0.504888890842109,570.372842410328,0.130068862702538,"lineage2","dr_mutations_pyrazinamide","PHE",0,"SRR671815,BGI_SH311","SRR671815","lineage2.2.1","cn","China","pnca_p.val7phe","A","E","VAL","VA7","pnca_complex.pdb"
|
|
"V7F","L4","PZA","V","V7",7,"F",1,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",5.336,0.042,-1.877,4.86315,-2.949,-1.55,83,91,-0.66,7,7,0,0,"strand",1.73333333333333,11.02,0.0002156101768003,9.70466975178797,9.70465898653049,9.70194990589383,2.29168245016684,-54,-2,0,0,-2,0,0,0,0,0,0,-2,0,0,0,0,0,-3,0,1,-4,-8,0,-6,-4,0.0188340807174887,-0.485012919896641,0.177126508788671,-0.502813299232737,-0.405759162303665,0.873684210526316,-0.543657331136738,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.779,-0.615,"8:7","146/150","V:I:A",2.27260607808817,0.06344559022609,1.22442760158496,1.8560559033024,0.929172866365903,208.881603004777,0.986980761010679,0.0776844925942494,1.10966566656461,0.504888890842109,570.372842410328,0.130068862702538,"lineage4","dr_mutations_pyrazinamide","PHE",0,"ERR2516523","ERR2516523","lineage4.1.1","pe","Peru","pnca_p.val7phe","A","E","VAL","VA7","pnca_complex.pdb"
|
|
"V7G","L2","PZA","V","V7",7,"G",NA,"XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",5.336,-1.062,-3.114,5.26226,-4.33,-2.58,86,91,-0.66,7,7,0,0,"strand",1.73333333333333,11.02,0.001293661060802,39.0452814219213,39.0452813634446,39.0430804499264,60.5607562088978,12,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,3,0,1,2,8,0,11,21,-0.268996960486322,-0.804651162790698,0.191662963745365,-0.738277919863598,-0.675392670157068,0.905263157894737,-0.543657331136738,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.779,-0.615,"8:7","146/150","V:I:A",3.6647220332212,1.03849290922087e-06,0.750321763717271,4.88420063289289,11.103639297077,247.090478887866,1.59156855738766,5.52264644232101e-11,10.2578527592503,9.16748833639401,349.97982252054,7.13421964779937e-15,"lineage2","dr_mutations_pyrazinamide","GLY",0,"SAMN02628499","SRR1172711_SRR1173722","lineage2.2.1","ir","Iran","pnca_p.val7gly","A","E","VAL","VA7","pnca_complex.pdb"
|
|
"V7G","L2","PZA","V","V7",7,"G",1,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",5.336,-1.062,-3.114,5.26226,-4.33,-2.58,86,91,-0.66,7,7,0,0,"strand",1.73333333333333,11.02,0.001293661060802,39.0452814219213,39.0452813634446,39.0430804499264,60.5607562088978,12,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,3,0,1,2,8,0,11,21,-0.268996960486322,-0.804651162790698,0.191662963745365,-0.738277919863598,-0.675392670157068,0.905263157894737,-0.543657331136738,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.779,-0.615,"8:7","146/150","V:I:A",3.6647220332212,1.03849290922087e-06,0.750321763717271,4.88420063289289,11.103639297077,247.090478887866,1.59156855738766,5.52264644232101e-11,10.2578527592503,9.16748833639401,349.97982252054,7.13421964779937e-15,"lineage2","dr_mutations_pyrazinamide","GLY",0,"MDR_22242","SRR6824593","lineage2.2.1","cn","China: Fengjie County, Chongqing","pnca_p.val7gly","A","E","VAL","VA7","pnca_complex.pdb"
|
|
"V7G","L2","PZA","V","V7",7,"G",1,"Pre-MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",5.336,-1.062,-3.114,5.26226,-4.33,-2.58,86,91,-0.66,7,7,0,0,"strand",1.73333333333333,11.02,0.001293661060802,39.0452814219213,39.0452813634446,39.0430804499264,60.5607562088978,12,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,3,0,1,2,8,0,11,21,-0.268996960486322,-0.804651162790698,0.191662963745365,-0.738277919863598,-0.675392670157068,0.905263157894737,-0.543657331136738,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.779,-0.615,"8:7","146/150","V:I:A",3.6647220332212,1.03849290922087e-06,0.750321763717271,4.88420063289289,11.103639297077,247.090478887866,1.59156855738766,5.52264644232101e-11,10.2578527592503,9.16748833639401,349.97982252054,7.13421964779937e-15,"lineage2","dr_mutations_pyrazinamide","GLY",0,"ERR144542,1769Z-sc-2012-02-21T11:37:21Z-1364779","ERR144542","lineage2.2.1","ru","Russia,Samara","pnca_p.val7gly","A","E","VAL","VA7","pnca_complex.pdb"
|
|
"V7G","L2","PZA","V","V7",7,"G",1,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",5.336,-1.062,-3.114,5.26226,-4.33,-2.58,86,91,-0.66,7,7,0,0,"strand",1.73333333333333,11.02,0.001293661060802,39.0452814219213,39.0452813634446,39.0430804499264,60.5607562088978,12,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,3,0,1,2,8,0,11,21,-0.268996960486322,-0.804651162790698,0.191662963745365,-0.738277919863598,-0.675392670157068,0.905263157894737,-0.543657331136738,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.779,-0.615,"8:7","146/150","V:I:A",3.6647220332212,1.03849290922087e-06,0.750321763717271,4.88420063289289,11.103639297077,247.090478887866,1.59156855738766,5.52264644232101e-11,10.2578527592503,9.16748833639401,349.97982252054,7.13421964779937e-15,"lineage2","dr_mutations_pyrazinamide","GLY",0,"ERR2041800","ERR2041800","lineage2.2.1","rs","Serbia","pnca_p.val7gly","A","E","VAL","VA7","pnca_complex.pdb"
|
|
"V7G","L2","PZA","V","V7",7,"G",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",5.336,-1.062,-3.114,5.26226,-4.33,-2.58,86,91,-0.66,7,7,0,0,"strand",1.73333333333333,11.02,0.001293661060802,39.0452814219213,39.0452813634446,39.0430804499264,60.5607562088978,12,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,3,0,1,2,8,0,11,21,-0.268996960486322,-0.804651162790698,0.191662963745365,-0.738277919863598,-0.675392670157068,0.905263157894737,-0.543657331136738,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.779,-0.615,"8:7","146/150","V:I:A",3.6647220332212,1.03849290922087e-06,0.750321763717271,4.88420063289289,11.103639297077,247.090478887866,1.59156855738766,5.52264644232101e-11,10.2578527592503,9.16748833639401,349.97982252054,7.13421964779937e-15,"lineage2","dr_mutations_pyrazinamide","GLY",0,"SRR5709871","SRR5709871","lineage2.2.1","th","Thailand","pnca_p.val7gly","A","E","VAL","VA7","pnca_complex.pdb"
|
|
"V7G","L2","PZA","V","V7",7,"G",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",5.336,-1.062,-3.114,5.26226,-4.33,-2.58,86,91,-0.66,7,7,0,0,"strand",1.73333333333333,11.02,0.001293661060802,39.0452814219213,39.0452813634446,39.0430804499264,60.5607562088978,12,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,3,0,1,2,8,0,11,21,-0.268996960486322,-0.804651162790698,0.191662963745365,-0.738277919863598,-0.675392670157068,0.905263157894737,-0.543657331136738,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.779,-0.615,"8:7","146/150","V:I:A",3.6647220332212,1.03849290922087e-06,0.750321763717271,4.88420063289289,11.103639297077,247.090478887866,1.59156855738766,5.52264644232101e-11,10.2578527592503,9.16748833639401,349.97982252054,7.13421964779937e-15,"lineage2","dr_mutations_pyrazinamide","GLY",0,"SRS797250","SRR1723776","lineage2.2.1","cn","China:Heilongjiang","pnca_p.val7gly","A","E","VAL","VA7","pnca_complex.pdb"
|
|
"V7G","L2","PZA","V","V7",7,"G",1,"Pre-MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",5.336,-1.062,-3.114,5.26226,-4.33,-2.58,86,91,-0.66,7,7,0,0,"strand",1.73333333333333,11.02,0.001293661060802,39.0452814219213,39.0452813634446,39.0430804499264,60.5607562088978,12,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,3,0,1,2,8,0,11,21,-0.268996960486322,-0.804651162790698,0.191662963745365,-0.738277919863598,-0.675392670157068,0.905263157894737,-0.543657331136738,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.779,-0.615,"8:7","146/150","V:I:A",3.6647220332212,1.03849290922087e-06,0.750321763717271,4.88420063289289,11.103639297077,247.090478887866,1.59156855738766,5.52264644232101e-11,10.2578527592503,9.16748833639401,349.97982252054,7.13421964779937e-15,"lineage2","dr_mutations_pyrazinamide","GLY",0,"0153S-sc-2012-02-09T18:55:34Z-1355148,ERR133815","ERR133815","lineage2.2.1","ru","Russia,Samara","pnca_p.val7gly","A","E","VAL","VA7","pnca_complex.pdb"
|
|
"V7G","L2","PZA","V","V7",7,"G",1,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",5.336,-1.062,-3.114,5.26226,-4.33,-2.58,86,91,-0.66,7,7,0,0,"strand",1.73333333333333,11.02,0.001293661060802,39.0452814219213,39.0452813634446,39.0430804499264,60.5607562088978,12,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,3,0,1,2,8,0,11,21,-0.268996960486322,-0.804651162790698,0.191662963745365,-0.738277919863598,-0.675392670157068,0.905263157894737,-0.543657331136738,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.779,-0.615,"8:7","146/150","V:I:A",3.6647220332212,1.03849290922087e-06,0.750321763717271,4.88420063289289,11.103639297077,247.090478887866,1.59156855738766,5.52264644232101e-11,10.2578527592503,9.16748833639401,349.97982252054,7.13421964779937e-15,"lineage2","dr_mutations_pyrazinamide","GLY",0,"ERR2041716","ERR2041716","lineage2.2.1","rs","Serbia","pnca_p.val7gly","A","E","VAL","VA7","pnca_complex.pdb"
|
|
"V7G","L2","PZA","V","V7",7,"G",NA,"XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",5.336,-1.062,-3.114,5.26226,-4.33,-2.58,86,91,-0.66,7,7,0,0,"strand",1.73333333333333,11.02,0.001293661060802,39.0452814219213,39.0452813634446,39.0430804499264,60.5607562088978,12,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,3,0,1,2,8,0,11,21,-0.268996960486322,-0.804651162790698,0.191662963745365,-0.738277919863598,-0.675392670157068,0.905263157894737,-0.543657331136738,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.779,-0.615,"8:7","146/150","V:I:A",3.6647220332212,1.03849290922087e-06,0.750321763717271,4.88420063289289,11.103639297077,247.090478887866,1.59156855738766,5.52264644232101e-11,10.2578527592503,9.16748833639401,349.97982252054,7.13421964779937e-15,"lineage2","dr_mutations_pyrazinamide","GLY",0,"SAMN02628498","SRR1173393_SRR1174307","lineage2.2.1","ir","Iran","pnca_p.val7gly","A","E","VAL","VA7","pnca_complex.pdb"
|
|
"V7G","L2","PZA","V","V7",7,"G",1,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",5.336,-1.062,-3.114,5.26226,-4.33,-2.58,86,91,-0.66,7,7,0,0,"strand",1.73333333333333,11.02,0.001293661060802,39.0452814219213,39.0452813634446,39.0430804499264,60.5607562088978,12,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,3,0,1,2,8,0,11,21,-0.268996960486322,-0.804651162790698,0.191662963745365,-0.738277919863598,-0.675392670157068,0.905263157894737,-0.543657331136738,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.779,-0.615,"8:7","146/150","V:I:A",3.6647220332212,1.03849290922087e-06,0.750321763717271,4.88420063289289,11.103639297077,247.090478887866,1.59156855738766,5.52264644232101e-11,10.2578527592503,9.16748833639401,349.97982252054,7.13421964779937e-15,"lineage2","dr_mutations_pyrazinamide","GLY",0,"ERR228043,2294V-sc-2012-10-11T13:38:29Z-1494207","ERR228043","lineage2.2.1","ru","Russia,Samara","pnca_p.val7gly","A","E","VAL","VA7","pnca_complex.pdb"
|
|
"V7G","L4","PZA","V","V7",7,"G",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",5.336,-1.062,-3.114,5.26226,-4.33,-2.58,86,91,-0.66,7,7,0,0,"strand",1.73333333333333,11.02,0.001293661060802,39.0452814219213,39.0452813634446,39.0430804499264,60.5607562088978,12,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,3,0,1,2,8,0,11,21,-0.268996960486322,-0.804651162790698,0.191662963745365,-0.738277919863598,-0.675392670157068,0.905263157894737,-0.543657331136738,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.779,-0.615,"8:7","146/150","V:I:A",3.6647220332212,1.03849290922087e-06,0.750321763717271,4.88420063289289,11.103639297077,247.090478887866,1.59156855738766,5.52264644232101e-11,10.2578527592503,9.16748833639401,349.97982252054,7.13421964779937e-15,"lineage4","dr_mutations_pyrazinamide","GLY",0,"SAMN02231161","SRR1049969_SRR1049970_SRR998773_SRR998774_SRR998772_SRR998775","lineage4.1","ml","Mali","pnca_p.val7gly","A","E","VAL","VA7","pnca_complex.pdb"
|
|
"V7G","L2","PZA","V","V7",7,"G",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",5.336,-1.062,-3.114,5.26226,-4.33,-2.58,86,91,-0.66,7,7,0,0,"strand",1.73333333333333,11.02,0.001293661060802,39.0452814219213,39.0452813634446,39.0430804499264,60.5607562088978,12,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,3,0,1,2,8,0,11,21,-0.268996960486322,-0.804651162790698,0.191662963745365,-0.738277919863598,-0.675392670157068,0.905263157894737,-0.543657331136738,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.779,-0.615,"8:7","146/150","V:I:A",3.6647220332212,1.03849290922087e-06,0.750321763717271,4.88420063289289,11.103639297077,247.090478887866,1.59156855738766,5.52264644232101e-11,10.2578527592503,9.16748833639401,349.97982252054,7.13421964779937e-15,"lineage2","dr_mutations_pyrazinamide","GLY",0,"0738D-sc-2011-10-12T14:59:45Z-1289190,ERR117456","ERR117456","lineage2.2.1","ru","Russia","pnca_p.val7gly","A","E","VAL","VA7","pnca_complex.pdb"
|
|
"V7G","L2","PZA","V","V7",7,"G",1,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",5.336,-1.062,-3.114,5.26226,-4.33,-2.58,86,91,-0.66,7,7,0,0,"strand",1.73333333333333,11.02,0.001293661060802,39.0452814219213,39.0452813634446,39.0430804499264,60.5607562088978,12,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,3,0,1,2,8,0,11,21,-0.268996960486322,-0.804651162790698,0.191662963745365,-0.738277919863598,-0.675392670157068,0.905263157894737,-0.543657331136738,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.779,-0.615,"8:7","146/150","V:I:A",3.6647220332212,1.03849290922087e-06,0.750321763717271,4.88420063289289,11.103639297077,247.090478887866,1.59156855738766,5.52264644232101e-11,10.2578527592503,9.16748833639401,349.97982252054,7.13421964779937e-15,"lineage2","dr_mutations_pyrazinamide","GLY",0,"ERR2200148","ERR2200148","lineage2.2.1","rs","Serbia","pnca_p.val7gly","A","E","VAL","VA7","pnca_complex.pdb"
|
|
"V7G","L2","PZA","V","V7",7,"G",1,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",5.336,-1.062,-3.114,5.26226,-4.33,-2.58,86,91,-0.66,7,7,0,0,"strand",1.73333333333333,11.02,0.001293661060802,39.0452814219213,39.0452813634446,39.0430804499264,60.5607562088978,12,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,3,0,1,2,8,0,11,21,-0.268996960486322,-0.804651162790698,0.191662963745365,-0.738277919863598,-0.675392670157068,0.905263157894737,-0.543657331136738,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.779,-0.615,"8:7","146/150","V:I:A",3.6647220332212,1.03849290922087e-06,0.750321763717271,4.88420063289289,11.103639297077,247.090478887866,1.59156855738766,5.52264644232101e-11,10.2578527592503,9.16748833639401,349.97982252054,7.13421964779937e-15,"lineage2","dr_mutations_pyrazinamide","GLY",0,"ERR2041695","ERR2041695","lineage2.2.1","rs","Serbia","pnca_p.val7gly","A","E","VAL","VA7","pnca_complex.pdb"
|
|
"V7G","L4","PZA","V","V7",7,"G",1,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",5.336,-1.062,-3.114,5.26226,-4.33,-2.58,86,91,-0.66,7,7,0,0,"strand",1.73333333333333,11.02,0.001293661060802,39.0452814219213,39.0452813634446,39.0430804499264,60.5607562088978,12,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,3,0,1,2,8,0,11,21,-0.268996960486322,-0.804651162790698,0.191662963745365,-0.738277919863598,-0.675392670157068,0.905263157894737,-0.543657331136738,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.779,-0.615,"8:7","146/150","V:I:A",3.6647220332212,1.03849290922087e-06,0.750321763717271,4.88420063289289,11.103639297077,247.090478887866,1.59156855738766,5.52264644232101e-11,10.2578527592503,9.16748833639401,349.97982252054,7.13421964779937e-15,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERS2592788","ERR2677442","lineage4.2.2.1","de","Germany","pnca_p.val7gly","A","E","VAL","VA7","pnca_complex.pdb"
|
|
"V7G","L2","PZA","V","V7",7,"G",1,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",5.336,-1.062,-3.114,5.26226,-4.33,-2.58,86,91,-0.66,7,7,0,0,"strand",1.73333333333333,11.02,0.001293661060802,39.0452814219213,39.0452813634446,39.0430804499264,60.5607562088978,12,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,3,0,1,2,8,0,11,21,-0.268996960486322,-0.804651162790698,0.191662963745365,-0.738277919863598,-0.675392670157068,0.905263157894737,-0.543657331136738,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.779,-0.615,"8:7","146/150","V:I:A",3.6647220332212,1.03849290922087e-06,0.750321763717271,4.88420063289289,11.103639297077,247.090478887866,1.59156855738766,5.52264644232101e-11,10.2578527592503,9.16748833639401,349.97982252054,7.13421964779937e-15,"lineage2","dr_mutations_pyrazinamide","GLY",0,"MDR_8213","SRR6824586","lineage2.2.1","cn","China: Bin County, Harbin City, Heilongjiang Province","pnca_p.val7gly","A","E","VAL","VA7","pnca_complex.pdb"
|
|
"V7G","L2","PZA","V","V7",7,"G",1,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",5.336,-1.062,-3.114,5.26226,-4.33,-2.58,86,91,-0.66,7,7,0,0,"strand",1.73333333333333,11.02,0.001293661060802,39.0452814219213,39.0452813634446,39.0430804499264,60.5607562088978,12,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,3,0,1,2,8,0,11,21,-0.268996960486322,-0.804651162790698,0.191662963745365,-0.738277919863598,-0.675392670157068,0.905263157894737,-0.543657331136738,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.779,-0.615,"8:7","146/150","V:I:A",3.6647220332212,1.03849290922087e-06,0.750321763717271,4.88420063289289,11.103639297077,247.090478887866,1.59156855738766,5.52264644232101e-11,10.2578527592503,9.16748833639401,349.97982252054,7.13421964779937e-15,"lineage2","dr_mutations_pyrazinamide","GLY",0,"ERR2510712","ERR2510712","lineage2.2.1","it","Italy","pnca_p.val7gly","A","E","VAL","VA7","pnca_complex.pdb"
|
|
"V7G","L2","PZA","V","V7",7,"G",1,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",5.336,-1.062,-3.114,5.26226,-4.33,-2.58,86,91,-0.66,7,7,0,0,"strand",1.73333333333333,11.02,0.001293661060802,39.0452814219213,39.0452813634446,39.0430804499264,60.5607562088978,12,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,3,0,1,2,8,0,11,21,-0.268996960486322,-0.804651162790698,0.191662963745365,-0.738277919863598,-0.675392670157068,0.905263157894737,-0.543657331136738,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.779,-0.615,"8:7","146/150","V:I:A",3.6647220332212,1.03849290922087e-06,0.750321763717271,4.88420063289289,11.103639297077,247.090478887866,1.59156855738766,5.52264644232101e-11,10.2578527592503,9.16748833639401,349.97982252054,7.13421964779937e-15,"lineage2","dr_mutations_pyrazinamide","GLY",0,"ERR2516243","ERR2516243","lineage2.2.1","be","Belgium","pnca_p.val7gly","A","E","VAL","VA7","pnca_complex.pdb"
|
|
"V7G","L2","PZA","V","V7",7,"G",1,"Pre-MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",5.336,-1.062,-3.114,5.26226,-4.33,-2.58,86,91,-0.66,7,7,0,0,"strand",1.73333333333333,11.02,0.001293661060802,39.0452814219213,39.0452813634446,39.0430804499264,60.5607562088978,12,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,3,0,1,2,8,0,11,21,-0.268996960486322,-0.804651162790698,0.191662963745365,-0.738277919863598,-0.675392670157068,0.905263157894737,-0.543657331136738,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.779,-0.615,"8:7","146/150","V:I:A",3.6647220332212,1.03849290922087e-06,0.750321763717271,4.88420063289289,11.103639297077,247.090478887866,1.59156855738766,5.52264644232101e-11,10.2578527592503,9.16748833639401,349.97982252054,7.13421964779937e-15,"lineage2","dr_mutations_pyrazinamide","GLY",0,"ERR133900,0667B-sc-2012-02-09T18:56:39Z-1355233","ERR133900","lineage2.2.1","ru","Russia,Samara","pnca_p.val7gly","A","E","VAL","VA7","pnca_complex.pdb"
|
|
"V7G","L2","PZA","V","V7",7,"G",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",5.336,-1.062,-3.114,5.26226,-4.33,-2.58,86,91,-0.66,7,7,0,0,"strand",1.73333333333333,11.02,0.001293661060802,39.0452814219213,39.0452813634446,39.0430804499264,60.5607562088978,12,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,3,0,1,2,8,0,11,21,-0.268996960486322,-0.804651162790698,0.191662963745365,-0.738277919863598,-0.675392670157068,0.905263157894737,-0.543657331136738,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.779,-0.615,"8:7","146/150","V:I:A",3.6647220332212,1.03849290922087e-06,0.750321763717271,4.88420063289289,11.103639297077,247.090478887866,1.59156855738766,5.52264644232101e-11,10.2578527592503,9.16748833639401,349.97982252054,7.13421964779937e-15,"lineage2","dr_mutations_pyrazinamide","GLY",0,"BGI_142,SRR671721","SRR671721","lineage2.2.1","cn","China","pnca_p.val7gly","A","E","VAL","VA7","pnca_complex.pdb"
|
|
"V7G","L2","PZA","V","V7",7,"G",0,"Pre-MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",5.336,-1.062,-3.114,5.26226,-4.33,-2.58,86,91,-0.66,7,7,0,0,"strand",1.73333333333333,11.02,0.001293661060802,39.0452814219213,39.0452813634446,39.0430804499264,60.5607562088978,12,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,3,0,1,2,8,0,11,21,-0.268996960486322,-0.804651162790698,0.191662963745365,-0.738277919863598,-0.675392670157068,0.905263157894737,-0.543657331136738,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.779,-0.615,"8:7","146/150","V:I:A",3.6647220332212,1.03849290922087e-06,0.750321763717271,4.88420063289289,11.103639297077,247.090478887866,1.59156855738766,5.52264644232101e-11,10.2578527592503,9.16748833639401,349.97982252054,7.13421964779937e-15,"lineage2","dr_mutations_pyrazinamide","GLY",0,"ERR133888,0589R-sc-2012-02-09T18:56:26Z-1355221","ERR133888","lineage2.2.1","ru","Russia,Samara","pnca_p.val7gly","A","E","VAL","VA7","pnca_complex.pdb"
|
|
"V7G","L2","PZA","V","V7",7,"G",1,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",5.336,-1.062,-3.114,5.26226,-4.33,-2.58,86,91,-0.66,7,7,0,0,"strand",1.73333333333333,11.02,0.001293661060802,39.0452814219213,39.0452813634446,39.0430804499264,60.5607562088978,12,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,3,0,1,2,8,0,11,21,-0.268996960486322,-0.804651162790698,0.191662963745365,-0.738277919863598,-0.675392670157068,0.905263157894737,-0.543657331136738,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.779,-0.615,"8:7","146/150","V:I:A",3.6647220332212,1.03849290922087e-06,0.750321763717271,4.88420063289289,11.103639297077,247.090478887866,1.59156855738766,5.52264644232101e-11,10.2578527592503,9.16748833639401,349.97982252054,7.13421964779937e-15,"lineage2","dr_mutations_pyrazinamide","GLY",0,"ERR2041704","ERR2041704","lineage2.2.1","rs","Serbia","pnca_p.val7gly","A","E","VAL","VA7","pnca_complex.pdb"
|
|
"V7G","L2","PZA","V","V7",7,"G",NA,"XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",5.336,-1.062,-3.114,5.26226,-4.33,-2.58,86,91,-0.66,7,7,0,0,"strand",1.73333333333333,11.02,0.001293661060802,39.0452814219213,39.0452813634446,39.0430804499264,60.5607562088978,12,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,3,0,1,2,8,0,11,21,-0.268996960486322,-0.804651162790698,0.191662963745365,-0.738277919863598,-0.675392670157068,0.905263157894737,-0.543657331136738,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.779,-0.615,"8:7","146/150","V:I:A",3.6647220332212,1.03849290922087e-06,0.750321763717271,4.88420063289289,11.103639297077,247.090478887866,1.59156855738766,5.52264644232101e-11,10.2578527592503,9.16748833639401,349.97982252054,7.13421964779937e-15,"lineage2","dr_mutations_pyrazinamide","GLY",0,"ERR144591","ERR144591","lineage2.2.1","ru","Russia","pnca_p.val7gly","A","E","VAL","VA7","pnca_complex.pdb"
|
|
"V7G","L2","PZA","V","V7",7,"G",0,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",5.336,-1.062,-3.114,5.26226,-4.33,-2.58,86,91,-0.66,7,7,0,0,"strand",1.73333333333333,11.02,0.001293661060802,39.0452814219213,39.0452813634446,39.0430804499264,60.5607562088978,12,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,3,0,1,2,8,0,11,21,-0.268996960486322,-0.804651162790698,0.191662963745365,-0.738277919863598,-0.675392670157068,0.905263157894737,-0.543657331136738,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.779,-0.615,"8:7","146/150","V:I:A",3.6647220332212,1.03849290922087e-06,0.750321763717271,4.88420063289289,11.103639297077,247.090478887866,1.59156855738766,5.52264644232101e-11,10.2578527592503,9.16748833639401,349.97982252054,7.13421964779937e-15,"lineage2","dr_mutations_pyrazinamide","GLY",0,"ERR2041685","ERR2041685","lineage2.2.1","rs","Serbia","pnca_p.val7gly","A","E","VAL","VA7","pnca_complex.pdb"
|
|
"V7G","L2","PZA","V","V7",7,"G",1,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",5.336,-1.062,-3.114,5.26226,-4.33,-2.58,86,91,-0.66,7,7,0,0,"strand",1.73333333333333,11.02,0.001293661060802,39.0452814219213,39.0452813634446,39.0430804499264,60.5607562088978,12,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,3,0,1,2,8,0,11,21,-0.268996960486322,-0.804651162790698,0.191662963745365,-0.738277919863598,-0.675392670157068,0.905263157894737,-0.543657331136738,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.779,-0.615,"8:7","146/150","V:I:A",3.6647220332212,1.03849290922087e-06,0.750321763717271,4.88420063289289,11.103639297077,247.090478887866,1.59156855738766,5.52264644232101e-11,10.2578527592503,9.16748833639401,349.97982252054,7.13421964779937e-15,"lineage2","dr_mutations_pyrazinamide","GLY",0,"ERR2041691","ERR2041691","lineage2.2.1","rs","Serbia","pnca_p.val7gly","A","E","VAL","VA7","pnca_complex.pdb"
|
|
"V7G","L2","PZA","V","V7",7,"G",1,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",5.336,-1.062,-3.114,5.26226,-4.33,-2.58,86,91,-0.66,7,7,0,0,"strand",1.73333333333333,11.02,0.001293661060802,39.0452814219213,39.0452813634446,39.0430804499264,60.5607562088978,12,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,3,0,1,2,8,0,11,21,-0.268996960486322,-0.804651162790698,0.191662963745365,-0.738277919863598,-0.675392670157068,0.905263157894737,-0.543657331136738,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.779,-0.615,"8:7","146/150","V:I:A",3.6647220332212,1.03849290922087e-06,0.750321763717271,4.88420063289289,11.103639297077,247.090478887866,1.59156855738766,5.52264644232101e-11,10.2578527592503,9.16748833639401,349.97982252054,7.13421964779937e-15,"lineage2","dr_mutations_pyrazinamide","GLY",0,"ERR2041706","ERR2041706","lineage2.2.1","rs","Serbia","pnca_p.val7gly","A","E","VAL","VA7","pnca_complex.pdb"
|
|
"V7G","L2","PZA","V","V7",7,"G",NA,"XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",5.336,-1.062,-3.114,5.26226,-4.33,-2.58,86,91,-0.66,7,7,0,0,"strand",1.73333333333333,11.02,0.001293661060802,39.0452814219213,39.0452813634446,39.0430804499264,60.5607562088978,12,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,3,0,1,2,8,0,11,21,-0.268996960486322,-0.804651162790698,0.191662963745365,-0.738277919863598,-0.675392670157068,0.905263157894737,-0.543657331136738,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.779,-0.615,"8:7","146/150","V:I:A",3.6647220332212,1.03849290922087e-06,0.750321763717271,4.88420063289289,11.103639297077,247.090478887866,1.59156855738766,5.52264644232101e-11,10.2578527592503,9.16748833639401,349.97982252054,7.13421964779937e-15,"lineage2","dr_mutations_pyrazinamide","GLY",0,"SAMN02628501","SRR1173446_SRR1173842","lineage2.2.1","ir","Iran","pnca_p.val7gly","A","E","VAL","VA7","pnca_complex.pdb"
|
|
"V7G","L2","PZA","V","V7",7,"G",NA,"XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",5.336,-1.062,-3.114,5.26226,-4.33,-2.58,86,91,-0.66,7,7,0,0,"strand",1.73333333333333,11.02,0.001293661060802,39.0452814219213,39.0452813634446,39.0430804499264,60.5607562088978,12,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,3,0,1,2,8,0,11,21,-0.268996960486322,-0.804651162790698,0.191662963745365,-0.738277919863598,-0.675392670157068,0.905263157894737,-0.543657331136738,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.779,-0.615,"8:7","146/150","V:I:A",3.6647220332212,1.03849290922087e-06,0.750321763717271,4.88420063289289,11.103639297077,247.090478887866,1.59156855738766,5.52264644232101e-11,10.2578527592503,9.16748833639401,349.97982252054,7.13421964779937e-15,"lineage2","dr_mutations_pyrazinamide","GLY",0,"SAMN02628500","SRR1173750_SRR1173675","lineage2.2.1","ir","Iran","pnca_p.val7gly","A","E","VAL","VA7","pnca_complex.pdb"
|
|
"V7G","L2","PZA","V","V7",7,"G",NA,"XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",5.336,-1.062,-3.114,5.26226,-4.33,-2.58,86,91,-0.66,7,7,0,0,"strand",1.73333333333333,11.02,0.001293661060802,39.0452814219213,39.0452813634446,39.0430804499264,60.5607562088978,12,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,3,0,1,2,8,0,11,21,-0.268996960486322,-0.804651162790698,0.191662963745365,-0.738277919863598,-0.675392670157068,0.905263157894737,-0.543657331136738,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.779,-0.615,"8:7","146/150","V:I:A",3.6647220332212,1.03849290922087e-06,0.750321763717271,4.88420063289289,11.103639297077,247.090478887866,1.59156855738766,5.52264644232101e-11,10.2578527592503,9.16748833639401,349.97982252054,7.13421964779937e-15,"lineage2","dr_mutations_pyrazinamide","GLY",0,"SAMN02628502","SRR1173792_SRR1173628","lineage2.2.1","ir","Iran","pnca_p.val7gly","A","E","VAL","VA7","pnca_complex.pdb"
|
|
"V7I","L4","PZA","V","V7",7,"I",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",5.336,-0.635,-0.898,-1.10338,-0.738,-0.73,46,71,-0.66,7,7,0,0,"strand",1.73333333333333,11.02,NA,NA,NA,NA,NA,-24,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,-4,0,2,-7,0,0,2,-2,-0.160840932117528,-0.232041343669251,-0.212139506267784,-0.125831202046036,-0.19109947643979,0.484210526315789,-0.543657331136738,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.779,-0.615,"8:7","146/150","V:I:A",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage4","dr_mutations_pyrazinamide","ILE",0,"SAMN02586003","SRR1196479_SRR1175056_SRR1184351_SRR1172851","lineage4.3.4.2","za","South Africa","pnca_p.val7ile","A","E","VAL","VA7","pnca_complex.pdb"
|
|
"V7L","L4","PZA","V","V7",7,"L",1,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",5.336,-0.589,-1.137,-0.847275,-2.289,-0.99,83,91,-0.66,7,7,0,0,"strand",1.73333333333333,11.02,0.0009343107661348,10.9471518987342,10.9471289278841,10.9440461901209,21.4040928993518,-26,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,-3,0,1,-4,-2,0,-2,2,-0.14918946301925,-0.293798449612403,-0.162899907713605,-0.390281329923274,-0.259162303664921,0.873684210526316,-0.543657331136738,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.779,-0.615,"8:7","146/150","V:I:A",2.39307722351576,6.83262964849249e-05,0.600967660910521,3.98203993188257,3.56185012264106,40.4315613280321,1.03930114423982,4.53835196843674e-05,4.34310182576657,3.05117591386949,48.6969925271007,3.71976276752962e-06,"lineage4","dr_mutations_pyrazinamide","LEU",0,"140603921,SAMN05276312","SRR3675218","lineage4.1.1.3","gb","UK","pnca_p.val7leu","A","E","VAL","VA7","pnca_complex.pdb"
|
|
"V7L","L4","PZA","V","V7",7,"L",0,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",5.336,-0.589,-1.137,-0.847275,-2.289,-0.99,83,91,-0.66,7,7,0,0,"strand",1.73333333333333,11.02,0.0009343107661348,10.9471518987342,10.9471289278841,10.9440461901209,21.4040928993518,-26,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,-3,0,1,-4,-2,0,-2,2,-0.14918946301925,-0.293798449612403,-0.162899907713605,-0.390281329923274,-0.259162303664921,0.873684210526316,-0.543657331136738,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.779,-0.615,"8:7","146/150","V:I:A",2.39307722351576,6.83262964849249e-05,0.600967660910521,3.98203993188257,3.56185012264106,40.4315613280321,1.03930114423982,4.53835196843674e-05,4.34310182576657,3.05117591386949,48.6969925271007,3.71976276752962e-06,"lineage4","dr_mutations_pyrazinamide","LEU",0,"ERR2514424","ERR2514424","lineage4.1.1.3","gb","UK","pnca_p.val7leu","A","E","VAL","VA7","pnca_complex.pdb"
|
|
"V7L","L4","PZA","V","V7",7,"L",1,"Pre-MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",5.336,-0.589,-1.137,-0.847275,-2.289,-0.99,83,91,-0.66,7,7,0,0,"strand",1.73333333333333,11.02,0.0009343107661348,10.9471518987342,10.9471289278841,10.9440461901209,21.4040928993518,-26,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,-3,0,1,-4,-2,0,-2,2,-0.14918946301925,-0.293798449612403,-0.162899907713605,-0.390281329923274,-0.259162303664921,0.873684210526316,-0.543657331136738,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.779,-0.615,"8:7","146/150","V:I:A",2.39307722351576,6.83262964849249e-05,0.600967660910521,3.98203993188257,3.56185012264106,40.4315613280321,1.03930114423982,4.53835196843674e-05,4.34310182576657,3.05117591386949,48.6969925271007,3.71976276752962e-06,"lineage4","dr_mutations_pyrazinamide","LEU",0,"SAMN03647145","SRR2099972","lineage4.1.1.3","","","pnca_p.val7leu","A","E","VAL","VA7","pnca_complex.pdb"
|
|
"V7L","L4","PZA","V","V7",7,"L",0,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",5.336,-0.589,-1.137,-0.847275,-2.289,-0.99,83,91,-0.66,7,7,0,0,"strand",1.73333333333333,11.02,0.0009343107661348,10.9471518987342,10.9471289278841,10.9440461901209,21.4040928993518,-26,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,-3,0,1,-4,-2,0,-2,2,-0.14918946301925,-0.293798449612403,-0.162899907713605,-0.390281329923274,-0.259162303664921,0.873684210526316,-0.543657331136738,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.779,-0.615,"8:7","146/150","V:I:A",2.39307722351576,6.83262964849249e-05,0.600967660910521,3.98203993188257,3.56185012264106,40.4315613280321,1.03930114423982,4.53835196843674e-05,4.34310182576657,3.05117591386949,48.6969925271007,3.71976276752962e-06,"lineage4","dr_mutations_pyrazinamide","LEU",0,"ERR2516816","ERR2516816","lineage4.1.1.3","gb","UK","pnca_p.val7leu","A","E","VAL","VA7","pnca_complex.pdb"
|
|
"V7L","L4","PZA","V","V7",7,"L",1,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",5.336,-0.589,-1.137,-0.847275,-2.289,-0.99,83,91,-0.66,7,7,0,0,"strand",1.73333333333333,11.02,0.0009343107661348,10.9471518987342,10.9471289278841,10.9440461901209,21.4040928993518,-26,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,-3,0,1,-4,-2,0,-2,2,-0.14918946301925,-0.293798449612403,-0.162899907713605,-0.390281329923274,-0.259162303664921,0.873684210526316,-0.543657331136738,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.779,-0.615,"8:7","146/150","V:I:A",2.39307722351576,6.83262964849249e-05,0.600967660910521,3.98203993188257,3.56185012264106,40.4315613280321,1.03930114423982,4.53835196843674e-05,4.34310182576657,3.05117591386949,48.6969925271007,3.71976276752962e-06,"lineage4","dr_mutations_pyrazinamide","LEU",0,"ERR2514982","ERR2514982","lineage4.1.1.3","gb","UK","pnca_p.val7leu","A","E","VAL","VA7","pnca_complex.pdb"
|
|
"V7L","L4","PZA","V","V7",7,"L",0,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",5.336,-0.589,-1.137,-0.847275,-2.289,-0.99,83,91,-0.66,7,7,0,0,"strand",1.73333333333333,11.02,0.0009343107661348,10.9471518987342,10.9471289278841,10.9440461901209,21.4040928993518,-26,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,-3,0,1,-4,-2,0,-2,2,-0.14918946301925,-0.293798449612403,-0.162899907713605,-0.390281329923274,-0.259162303664921,0.873684210526316,-0.543657331136738,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.779,-0.615,"8:7","146/150","V:I:A",2.39307722351576,6.83262964849249e-05,0.600967660910521,3.98203993188257,3.56185012264106,40.4315613280321,1.03930114423982,4.53835196843674e-05,4.34310182576657,3.05117591386949,48.6969925271007,3.71976276752962e-06,"lineage4","dr_mutations_pyrazinamide","LEU",0,"ERR2514947","ERR2514947","lineage4.1.1.3","gb","UK","pnca_p.val7leu","A","E","VAL","VA7","pnca_complex.pdb"
|
|
"V7L","L4","PZA","V","V7",7,"L",1,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",5.336,-0.589,-1.137,-0.847275,-2.289,-0.99,83,91,-0.66,7,7,0,0,"strand",1.73333333333333,11.02,0.0009343107661348,10.9471518987342,10.9471289278841,10.9440461901209,21.4040928993518,-26,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,-3,0,1,-4,-2,0,-2,2,-0.14918946301925,-0.293798449612403,-0.162899907713605,-0.390281329923274,-0.259162303664921,0.873684210526316,-0.543657331136738,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.779,-0.615,"8:7","146/150","V:I:A",2.39307722351576,6.83262964849249e-05,0.600967660910521,3.98203993188257,3.56185012264106,40.4315613280321,1.03930114423982,4.53835196843674e-05,4.34310182576657,3.05117591386949,48.6969925271007,3.71976276752962e-06,"lineage4","dr_mutations_pyrazinamide","LEU",0,"ERR2516831","ERR2516831","lineage4.1.1.3","gb","UK","pnca_p.val7leu","A","E","VAL","VA7","pnca_complex.pdb"
|
|
"V7L","L4","PZA","V","V7",7,"L",1,"Pre-MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",5.336,-0.589,-1.137,-0.847275,-2.289,-0.99,83,91,-0.66,7,7,0,0,"strand",1.73333333333333,11.02,0.0009343107661348,10.9471518987342,10.9471289278841,10.9440461901209,21.4040928993518,-26,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,-3,0,1,-4,-2,0,-2,2,-0.14918946301925,-0.293798449612403,-0.162899907713605,-0.390281329923274,-0.259162303664921,0.873684210526316,-0.543657331136738,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.779,-0.615,"8:7","146/150","V:I:A",2.39307722351576,6.83262964849249e-05,0.600967660910521,3.98203993188257,3.56185012264106,40.4315613280321,1.03930114423982,4.53835196843674e-05,4.34310182576657,3.05117591386949,48.6969925271007,3.71976276752962e-06,"lineage4","dr_mutations_pyrazinamide","LEU",0,"SAMN03647894,SRR2100721","SRR2100721","lineage4.1.1.3","","","pnca_p.val7leu","A","E","VAL","VA7","pnca_complex.pdb"
|
|
"V7L","L4","PZA","V","V7",7,"L",1,"Pre-MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",5.336,-0.589,-1.137,-0.847275,-2.289,-0.99,83,91,-0.66,7,7,0,0,"strand",1.73333333333333,11.02,0.0009343107661348,10.9471518987342,10.9471289278841,10.9440461901209,21.4040928993518,-26,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,-3,0,1,-4,-2,0,-2,2,-0.14918946301925,-0.293798449612403,-0.162899907713605,-0.390281329923274,-0.259162303664921,0.873684210526316,-0.543657331136738,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.779,-0.615,"8:7","146/150","V:I:A",2.39307722351576,6.83262964849249e-05,0.600967660910521,3.98203993188257,3.56185012264106,40.4315613280321,1.03930114423982,4.53835196843674e-05,4.34310182576657,3.05117591386949,48.6969925271007,3.71976276752962e-06,"lineage4","dr_mutations_pyrazinamide","LEU",0,"SRR2101039,SAMN03648286","SRR2101039","lineage4.1.1.3","","","pnca_p.val7leu","A","E","VAL","VA7","pnca_complex.pdb"
|
|
"V7L","L4","PZA","V","V7",7,"L",1,"Pre-MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",5.336,-0.589,-1.137,-0.847275,-2.289,-0.99,83,91,-0.66,7,7,0,0,"strand",1.73333333333333,11.02,0.0009343107661348,10.9471518987342,10.9471289278841,10.9440461901209,21.4040928993518,-26,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,-3,0,1,-4,-2,0,-2,2,-0.14918946301925,-0.293798449612403,-0.162899907713605,-0.390281329923274,-0.259162303664921,0.873684210526316,-0.543657331136738,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.779,-0.615,"8:7","146/150","V:I:A",2.39307722351576,6.83262964849249e-05,0.600967660910521,3.98203993188257,3.56185012264106,40.4315613280321,1.03930114423982,4.53835196843674e-05,4.34310182576657,3.05117591386949,48.6969925271007,3.71976276752962e-06,"lineage4","dr_mutations_pyrazinamide","LEU",0,"SRR2469373,SAMN04099730","SRR2469373","lineage4.1.1.3","","","pnca_p.val7leu","A","E","VAL","VA7","pnca_complex.pdb"
|
|
"V7L","L4","PZA","V","V7",7,"L",NA,"Pre-MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",5.336,-0.589,-1.137,-0.847275,-2.289,-0.99,83,91,-0.66,7,7,0,0,"strand",1.73333333333333,11.02,0.0009343107661348,10.9471518987342,10.9471289278841,10.9440461901209,21.4040928993518,-26,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,-3,0,1,-4,-2,0,-2,2,-0.14918946301925,-0.293798449612403,-0.162899907713605,-0.390281329923274,-0.259162303664921,0.873684210526316,-0.543657331136738,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.779,-0.615,"8:7","146/150","V:I:A",2.39307722351576,6.83262964849249e-05,0.600967660910521,3.98203993188257,3.56185012264106,40.4315613280321,1.03930114423982,4.53835196843674e-05,4.34310182576657,3.05117591386949,48.6969925271007,3.71976276752962e-06,"lineage4","dr_mutations_pyrazinamide","LEU",0,"SAMN04365146","SRR3055242","lineage4.1.1.3","","","pnca_p.val7leu","A","E","VAL","VA7","pnca_complex.pdb"
|
|
"V7L","L4","PZA","V","V7",7,"L",1,"Pre-MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",5.336,-0.589,-1.137,-0.847275,-2.289,-0.99,83,91,-0.66,7,7,0,0,"strand",1.73333333333333,11.02,0.0009343107661348,10.9471518987342,10.9471289278841,10.9440461901209,21.4040928993518,-26,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,-3,0,1,-4,-2,0,-2,2,-0.14918946301925,-0.293798449612403,-0.162899907713605,-0.390281329923274,-0.259162303664921,0.873684210526316,-0.543657331136738,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.779,-0.615,"8:7","146/150","V:I:A",2.39307722351576,6.83262964849249e-05,0.600967660910521,3.98203993188257,3.56185012264106,40.4315613280321,1.03930114423982,4.53835196843674e-05,4.34310182576657,3.05117591386949,48.6969925271007,3.71976276752962e-06,"lineage4","dr_mutations_pyrazinamide","LEU",0,"ERR2514008","ERR2514008","lineage4.1.1.3","gb","UK","pnca_p.val7leu","A","E","VAL","VA7","pnca_complex.pdb"
|
|
"V7L","L4","PZA","V","V7",7,"L",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",5.336,-0.589,-1.137,-0.847275,-2.289,-0.99,83,91,-0.66,7,7,0,0,"strand",1.73333333333333,11.02,0.0009343107661348,10.9471518987342,10.9471289278841,10.9440461901209,21.4040928993518,-26,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,-3,0,1,-4,-2,0,-2,2,-0.14918946301925,-0.293798449612403,-0.162899907713605,-0.390281329923274,-0.259162303664921,0.873684210526316,-0.543657331136738,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.779,-0.615,"8:7","146/150","V:I:A",2.39307722351576,6.83262964849249e-05,0.600967660910521,3.98203993188257,3.56185012264106,40.4315613280321,1.03930114423982,4.53835196843674e-05,4.34310182576657,3.05117591386949,48.6969925271007,3.71976276752962e-06,"lineage4","dr_mutations_pyrazinamide","LEU",0,"ERR2513631","ERR2513631","lineage4.1.1.3","gb","UK","pnca_p.val7leu","A","E","VAL","VA7","pnca_complex.pdb"
|
|
"V7L","L4","PZA","V","V7",7,"L",0,"XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",5.336,-0.589,-1.137,-0.847275,-2.289,-0.99,83,91,-0.66,7,7,0,0,"strand",1.73333333333333,11.02,0.0009343107661348,10.9471518987342,10.9471289278841,10.9440461901209,21.4040928993518,-26,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,-3,0,1,-4,-2,0,-2,2,-0.14918946301925,-0.293798449612403,-0.162899907713605,-0.390281329923274,-0.259162303664921,0.873684210526316,-0.543657331136738,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.779,-0.615,"8:7","146/150","V:I:A",2.39307722351576,6.83262964849249e-05,0.600967660910521,3.98203993188257,3.56185012264106,40.4315613280321,1.03930114423982,4.53835196843674e-05,4.34310182576657,3.05117591386949,48.6969925271007,3.71976276752962e-06,"lineage4","dr_mutations_pyrazinamide","LEU",0,"ERR2513957","ERR2513957","lineage4.1.1.3","gb","UK","pnca_p.val7leu","A","E","VAL","VA7","pnca_complex.pdb"
|
|
"V7L","L4","PZA","V","V7",7,"L",1,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",5.336,-0.589,-1.137,-0.847275,-2.289,-0.99,83,91,-0.66,7,7,0,0,"strand",1.73333333333333,11.02,0.0009343107661348,10.9471518987342,10.9471289278841,10.9440461901209,21.4040928993518,-26,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,-3,0,1,-4,-2,0,-2,2,-0.14918946301925,-0.293798449612403,-0.162899907713605,-0.390281329923274,-0.259162303664921,0.873684210526316,-0.543657331136738,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.779,-0.615,"8:7","146/150","V:I:A",2.39307722351576,6.83262964849249e-05,0.600967660910521,3.98203993188257,3.56185012264106,40.4315613280321,1.03930114423982,4.53835196843674e-05,4.34310182576657,3.05117591386949,48.6969925271007,3.71976276752962e-06,"lineage4","dr_mutations_pyrazinamide","LEU",0,"614509","SRR5007178","lineage4.1.1.3","gb","United Kingdom","pnca_p.val7leu","A","E","VAL","VA7","pnca_complex.pdb"
|
|
"V7L","L4","PZA","V","V7",7,"L",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",5.336,-0.589,-1.137,-0.847275,-2.289,-0.99,83,91,-0.66,7,7,0,0,"strand",1.73333333333333,11.02,0.0009343107661348,10.9471518987342,10.9471289278841,10.9440461901209,21.4040928993518,-26,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,-3,0,1,-4,-2,0,-2,2,-0.14918946301925,-0.293798449612403,-0.162899907713605,-0.390281329923274,-0.259162303664921,0.873684210526316,-0.543657331136738,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.779,-0.615,"8:7","146/150","V:I:A",2.39307722351576,6.83262964849249e-05,0.600967660910521,3.98203993188257,3.56185012264106,40.4315613280321,1.03930114423982,4.53835196843674e-05,4.34310182576657,3.05117591386949,48.6969925271007,3.71976276752962e-06,"lineage4","dr_mutations_pyrazinamide","LEU",0,"SAMN07660385","SRR6046819","lineage4.1.1.3","gb","UK","pnca_p.val7leu","A","E","VAL","VA7","pnca_complex.pdb"
|
|
"D8A","L2","PZA","D","D8",8,"A",NA,"Pre-XDR","DM","hydrophilic","hydrophobic","acidic","non-polar","neg","non-polar",3.22,-3.268,-0.511,0.541028,-1.125,0.4,87,91,-1.187,9,9,5,0.0259067357512953,"loop",1.63333333333333,9.48,0.0001437401178668,19.411022297013,511754.463552623,Inf,4.73122070382274,26,36,0,0,36,0,0,0,0,0,0,0,4,0,0,0,0,-5,0,-4,-1,0,0,6,1,-0.827760891590679,-0.132041343669251,0.0197054174345676,-0.191815856777494,0.224719101123595,0.91578947368421,-0.977759472817133,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-1.221,-1.178,"9:9","146/150","D:H",13.1456002256206,0.924803768447001,139.277183326572,0.094384449136922,0.0001628371344451,NA,1.28804840845689,0.0292235860951597,1.53426649183163,0.91081598550184,Inf,0.0296198560706035,"lineage2","dr_mutations_pyrazinamide","ALA",0,"SRR5709862,SAMN07236319","SRR5709862","lineage2.2.1","th","Thailand","pnca_p.asp8ala","A","-","ASP","DA8","pnca_complex.pdb"
|
|
"D8A","L2","PZA","D","D8",8,"A",NA,"Pre-MDR","DM","hydrophilic","hydrophobic","acidic","non-polar","neg","non-polar",3.22,-3.268,-0.511,0.541028,-1.125,0.4,87,91,-1.187,9,9,5,0.0259067357512953,"loop",1.63333333333333,9.48,0.0001437401178668,19.411022297013,511754.463552623,Inf,4.73122070382274,26,36,0,0,36,0,0,0,0,0,0,0,4,0,0,0,0,-5,0,-4,-1,0,0,6,1,-0.827760891590679,-0.132041343669251,0.0197054174345676,-0.191815856777494,0.224719101123595,0.91578947368421,-0.977759472817133,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-1.221,-1.178,"9:9","146/150","D:H",13.1456002256206,0.924803768447001,139.277183326572,0.094384449136922,0.0001628371344451,NA,1.28804840845689,0.0292235860951597,1.53426649183163,0.91081598550184,Inf,0.0296198560706035,"lineage2","dr_mutations_pyrazinamide","ALA",0,"SRS797286","SRR1723814_SRR1723813_SRR1723815","lineage2.2.1","cn","China:Anhui","pnca_p.asp8ala","A","-","ASP","DA8","pnca_complex.pdb"
|
|
"D8A","L2","PZA","D","D8",8,"A",1,"MDR","DM","hydrophilic","hydrophobic","acidic","non-polar","neg","non-polar",3.22,-3.268,-0.511,0.541028,-1.125,0.4,87,91,-1.187,9,9,5,0.0259067357512953,"loop",1.63333333333333,9.48,0.0001437401178668,19.411022297013,511754.463552623,Inf,4.73122070382274,26,36,0,0,36,0,0,0,0,0,0,0,4,0,0,0,0,-5,0,-4,-1,0,0,6,1,-0.827760891590679,-0.132041343669251,0.0197054174345676,-0.191815856777494,0.224719101123595,0.91578947368421,-0.977759472817133,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-1.221,-1.178,"9:9","146/150","D:H",13.1456002256206,0.924803768447001,139.277183326572,0.094384449136922,0.0001628371344451,NA,1.28804840845689,0.0292235860951597,1.53426649183163,0.91081598550184,Inf,0.0296198560706035,"lineage2","dr_mutations_pyrazinamide","ALA",0,"ERR553107","ERR553107","lineage2.2.1","in","India","pnca_p.asp8ala","A","-","ASP","DA8","pnca_complex.pdb"
|
|
"D8A","L2","PZA","D","D8",8,"A",NA,"Pre-XDR","DM","hydrophilic","hydrophobic","acidic","non-polar","neg","non-polar",3.22,-3.268,-0.511,0.541028,-1.125,0.4,87,91,-1.187,9,9,5,0.0259067357512953,"loop",1.63333333333333,9.48,0.0001437401178668,19.411022297013,511754.463552623,Inf,4.73122070382274,26,36,0,0,36,0,0,0,0,0,0,0,4,0,0,0,0,-5,0,-4,-1,0,0,6,1,-0.827760891590679,-0.132041343669251,0.0197054174345676,-0.191815856777494,0.224719101123595,0.91578947368421,-0.977759472817133,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-1.221,-1.178,"9:9","146/150","D:H",13.1456002256206,0.924803768447001,139.277183326572,0.094384449136922,0.0001628371344451,NA,1.28804840845689,0.0292235860951597,1.53426649183163,0.91081598550184,Inf,0.0296198560706035,"lineage2","dr_mutations_pyrazinamide","ALA",0,"SAMN07236317,SRR5709816","SRR5709816","lineage2.2.1","th","Thailand","pnca_p.asp8ala","A","-","ASP","DA8","pnca_complex.pdb"
|
|
"D8A","L4","PZA","D","D8",8,"A",NA,"MDR","DM","hydrophilic","hydrophobic","acidic","non-polar","neg","non-polar",3.22,-3.268,-0.511,0.541028,-1.125,0.4,87,91,-1.187,9,9,5,0.0259067357512953,"loop",1.63333333333333,9.48,0.0001437401178668,19.411022297013,511754.463552623,Inf,4.73122070382274,26,36,0,0,36,0,0,0,0,0,0,0,4,0,0,0,0,-5,0,-4,-1,0,0,6,1,-0.827760891590679,-0.132041343669251,0.0197054174345676,-0.191815856777494,0.224719101123595,0.91578947368421,-0.977759472817133,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-1.221,-1.178,"9:9","146/150","D:H",13.1456002256206,0.924803768447001,139.277183326572,0.094384449136922,0.0001628371344451,NA,1.28804840845689,0.0292235860951597,1.53426649183163,0.91081598550184,Inf,0.0296198560706035,"lineage4","dr_mutations_pyrazinamide","ALA",0,"ERR751520","ERR751520","lineage4.1.1","pe","","pnca_p.asp8ala","A","-","ASP","DA8","pnca_complex.pdb"
|
|
"D8A","L2","PZA","D","D8",8,"A",1,"Pre-MDR","DM","hydrophilic","hydrophobic","acidic","non-polar","neg","non-polar",3.22,-3.268,-0.511,0.541028,-1.125,0.4,87,91,-1.187,9,9,5,0.0259067357512953,"loop",1.63333333333333,9.48,0.0001437401178668,19.411022297013,511754.463552623,Inf,4.73122070382274,26,36,0,0,36,0,0,0,0,0,0,0,4,0,0,0,0,-5,0,-4,-1,0,0,6,1,-0.827760891590679,-0.132041343669251,0.0197054174345676,-0.191815856777494,0.224719101123595,0.91578947368421,-0.977759472817133,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-1.221,-1.178,"9:9","146/150","D:H",13.1456002256206,0.924803768447001,139.277183326572,0.094384449136922,0.0001628371344451,NA,1.28804840845689,0.0292235860951597,1.53426649183163,0.91081598550184,Inf,0.0296198560706035,"lineage2","dr_mutations_pyrazinamide","ALA",0,"MDR_12448","SRR6824632","lineage2.2.1","cn","China: Shou County, Lu'an City, Anhui Province","pnca_p.asp8ala","A","-","ASP","DA8","pnca_complex.pdb"
|
|
"D8E","L4","PZA","D","D8",8,"E",NA,"Pre-XDR","DM","hydrophilic","hydrophilic","acidic","acidic","neg","neg",3.22,0.012,-0.786,1.90122,-1.417,-0.4,90,95,-1.187,9,9,5,0.0259067357512953,"loop",1.63333333333333,9.48,0.0002874802357337,14.5631313131313,14.5630810302278,14.5631012253236,5.81873994206135,-24,-28,0,0,-28,0,0,0,0,-2,0,-2,0,0,0,0,0,2,0,2,-1,-8,0,-10,-6,0.0053811659192825,-0.203100775193798,0.0692465708520604,-0.241602728047741,-0.104712041884817,0.947368421052632,-0.977759472817133,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","146/150","D:H",2.67848962960141,0.0202679102821361,1.15384949648317,2.3213509541454,1.86363317860697,294.488177945815,1.16325476548539,0.0174140488202037,1.75910024233227,1.16837785201846,760.989759542733,0.0158563003544608,"lineage4","dr_mutations_pyrazinamide","GLU",0,"ERR2510171","ERR2510171","lineage4","pe","Peru","pnca_p.asp8glu","A","-","ASP","DA8","pnca_complex.pdb"
|
|
"D8E","L2","PZA","D","D8",8,"E",1,"MDR","DM","hydrophilic","hydrophilic","acidic","acidic","neg","neg",3.22,0.012,-0.786,1.90122,-1.417,-0.4,90,95,-1.187,9,9,5,0.0259067357512953,"loop",1.63333333333333,9.48,0.0002874802357337,14.5631313131313,14.5630810302278,14.5631012253236,5.81873994206135,-24,-28,0,0,-28,0,0,0,0,-2,0,-2,0,0,0,0,0,2,0,2,-1,-8,0,-10,-6,0.0053811659192825,-0.203100775193798,0.0692465708520604,-0.241602728047741,-0.104712041884817,0.947368421052632,-0.977759472817133,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","146/150","D:H",2.67848962960141,0.0202679102821361,1.15384949648317,2.3213509541454,1.86363317860697,294.488177945815,1.16325476548539,0.0174140488202037,1.75910024233227,1.16837785201846,760.989759542733,0.0158563003544608,"lineage2","dr_mutations_pyrazinamide","GLU",0,"ERR108421,1052V-sc-2011-10-12T14:58:09Z-1289086","ERR108421","lineage2.2.1","ru","Russia,Samara","pnca_p.asp8glu","A","-","ASP","DA8","pnca_complex.pdb"
|
|
"D8E","L2","PZA","D","D8",8,"E",NA,"MDR","DM","hydrophilic","hydrophilic","acidic","acidic","neg","neg",3.22,0.012,-0.786,1.90122,-1.417,-0.4,90,95,-1.187,9,9,5,0.0259067357512953,"loop",1.63333333333333,9.48,0.0002874802357337,14.5631313131313,14.5630810302278,14.5631012253236,5.81873994206135,-24,-28,0,0,-28,0,0,0,0,-2,0,-2,0,0,0,0,0,2,0,2,-1,-8,0,-10,-6,0.0053811659192825,-0.203100775193798,0.0692465708520604,-0.241602728047741,-0.104712041884817,0.947368421052632,-0.977759472817133,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","146/150","D:H",2.67848962960141,0.0202679102821361,1.15384949648317,2.3213509541454,1.86363317860697,294.488177945815,1.16325476548539,0.0174140488202037,1.75910024233227,1.16837785201846,760.989759542733,0.0158563003544608,"lineage2","dr_mutations_pyrazinamide","GLU",0,"ERR108477","ERR108477","lineage2.2.1","ru","Russia","pnca_p.asp8glu","A","-","ASP","DA8","pnca_complex.pdb"
|
|
"D8E","L4","PZA","D","D8",8,"E",NA,"Pre-XDR","DM","hydrophilic","hydrophilic","acidic","acidic","neg","neg",3.22,0.012,-0.786,1.90122,-1.417,-0.4,90,95,-1.187,9,9,5,0.0259067357512953,"loop",1.63333333333333,9.48,0.0002874802357337,14.5631313131313,14.5630810302278,14.5631012253236,5.81873994206135,-24,-28,0,0,-28,0,0,0,0,-2,0,-2,0,0,0,0,0,2,0,2,-1,-8,0,-10,-6,0.0053811659192825,-0.203100775193798,0.0692465708520604,-0.241602728047741,-0.104712041884817,0.947368421052632,-0.977759472817133,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","146/150","D:H",2.67848962960141,0.0202679102821361,1.15384949648317,2.3213509541454,1.86363317860697,294.488177945815,1.16325476548539,0.0174140488202037,1.75910024233227,1.16837785201846,760.989759542733,0.0158563003544608,"lineage4","dr_mutations_pyrazinamide","GLU",0,"ERR775389","ERR775389","lineage4","pe","","pnca_p.asp8glu","A","-","ASP","DA8","pnca_complex.pdb"
|
|
"D8E","L4","PZA","D","D8",8,"E",NA,"Pre-XDR","DM","hydrophilic","hydrophilic","acidic","acidic","neg","neg",3.22,0.012,-0.786,1.90122,-1.417,-0.4,90,95,-1.187,9,9,5,0.0259067357512953,"loop",1.63333333333333,9.48,0.0002874802357337,14.5631313131313,14.5630810302278,14.5631012253236,5.81873994206135,-24,-28,0,0,-28,0,0,0,0,-2,0,-2,0,0,0,0,0,2,0,2,-1,-8,0,-10,-6,0.0053811659192825,-0.203100775193798,0.0692465708520604,-0.241602728047741,-0.104712041884817,0.947368421052632,-0.977759472817133,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","146/150","D:H",2.67848962960141,0.0202679102821361,1.15384949648317,2.3213509541454,1.86363317860697,294.488177945815,1.16325476548539,0.0174140488202037,1.75910024233227,1.16837785201846,760.989759542733,0.0158563003544608,"lineage4","dr_mutations_pyrazinamide","GLU",0,"ERR1034831","ERR1034831","lineage4.3.4.1","pt","Portugal","pnca_p.asp8glu","A","-","ASP","DA8","pnca_complex.pdb"
|
|
"D8E","L2","PZA","D","D8",8,"E",1,"MDR","DM","hydrophilic","hydrophilic","acidic","acidic","neg","neg",3.22,0.012,-0.786,1.90122,-1.417,-0.4,90,95,-1.187,9,9,5,0.0259067357512953,"loop",1.63333333333333,9.48,0.0002874802357337,14.5631313131313,14.5630810302278,14.5631012253236,5.81873994206135,-24,-28,0,0,-28,0,0,0,0,-2,0,-2,0,0,0,0,0,2,0,2,-1,-8,0,-10,-6,0.0053811659192825,-0.203100775193798,0.0692465708520604,-0.241602728047741,-0.104712041884817,0.947368421052632,-0.977759472817133,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","146/150","D:H",2.67848962960141,0.0202679102821361,1.15384949648317,2.3213509541454,1.86363317860697,294.488177945815,1.16325476548539,0.0174140488202037,1.75910024233227,1.16837785201846,760.989759542733,0.0158563003544608,"lineage2","dr_mutations_pyrazinamide","GLU",0,"ERR2510862","ERR2510862","lineage2.2.1","it","Italy","pnca_p.asp8glu","A","-","ASP","DA8","pnca_complex.pdb"
|
|
"D8E","L2","PZA","D","D8",8,"E",0,"MDR","DM","hydrophilic","hydrophilic","acidic","acidic","neg","neg",3.22,0.012,-0.786,1.90122,-1.417,-0.4,90,95,-1.187,9,9,5,0.0259067357512953,"loop",1.63333333333333,9.48,0.0002874802357337,14.5631313131313,14.5630810302278,14.5631012253236,5.81873994206135,-24,-28,0,0,-28,0,0,0,0,-2,0,-2,0,0,0,0,0,2,0,2,-1,-8,0,-10,-6,0.0053811659192825,-0.203100775193798,0.0692465708520604,-0.241602728047741,-0.104712041884817,0.947368421052632,-0.977759472817133,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","146/150","D:H",2.67848962960141,0.0202679102821361,1.15384949648317,2.3213509541454,1.86363317860697,294.488177945815,1.16325476548539,0.0174140488202037,1.75910024233227,1.16837785201846,760.989759542733,0.0158563003544608,"lineage2","dr_mutations_pyrazinamide","GLU",0,"ERR553238,SAMEA2535237","ERR553238","lineage2.2.1","","","pnca_p.asp8glu","A","-","ASP","DA8","pnca_complex.pdb"
|
|
"D8E","L4","PZA","D","D8",8,"E",NA,"MDR","DM","hydrophilic","hydrophilic","acidic","acidic","neg","neg",3.22,0.012,-0.786,1.90122,-1.417,-0.4,90,95,-1.187,9,9,5,0.0259067357512953,"loop",1.63333333333333,9.48,0.0002874802357337,14.5631313131313,14.5630810302278,14.5631012253236,5.81873994206135,-24,-28,0,0,-28,0,0,0,0,-2,0,-2,0,0,0,0,0,2,0,2,-1,-8,0,-10,-6,0.0053811659192825,-0.203100775193798,0.0692465708520604,-0.241602728047741,-0.104712041884817,0.947368421052632,-0.977759472817133,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","146/150","D:H",2.67848962960141,0.0202679102821361,1.15384949648317,2.3213509541454,1.86363317860697,294.488177945815,1.16325476548539,0.0174140488202037,1.75910024233227,1.16837785201846,760.989759542733,0.0158563003544608,"lineage4","dr_mutations_pyrazinamide","GLU",0,"ERR2707214","ERR2707214","lineage4.1.1","cd","Democratic Republic of Congo","pnca_p.asp8glu","A","-","ASP","DA8","pnca_complex.pdb"
|
|
"D8E","L4","PZA","D","D8",8,"E",NA,"Pre-XDR","DM","hydrophilic","hydrophilic","acidic","acidic","neg","neg",3.22,0.012,-0.786,1.90122,-1.417,-0.4,90,95,-1.187,9,9,5,0.0259067357512953,"loop",1.63333333333333,9.48,0.0002874802357337,14.5631313131313,14.5630810302278,14.5631012253236,5.81873994206135,-24,-28,0,0,-28,0,0,0,0,-2,0,-2,0,0,0,0,0,2,0,2,-1,-8,0,-10,-6,0.0053811659192825,-0.203100775193798,0.0692465708520604,-0.241602728047741,-0.104712041884817,0.947368421052632,-0.977759472817133,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","146/150","D:H",2.67848962960141,0.0202679102821361,1.15384949648317,2.3213509541454,1.86363317860697,294.488177945815,1.16325476548539,0.0174140488202037,1.75910024233227,1.16837785201846,760.989759542733,0.0158563003544608,"lineage4","dr_mutations_pyrazinamide","GLU",0,"ERR845936","ERR845936","lineage4","pe","","pnca_p.asp8glu","A","-","ASP","DA8","pnca_complex.pdb"
|
|
"D8E","L2","PZA","D","D8",8,"E",1,"Pre-XDR","DM","hydrophilic","hydrophilic","acidic","acidic","neg","neg",3.22,0.012,-0.786,1.90122,-1.417,-0.4,90,95,-1.187,9,9,5,0.0259067357512953,"loop",1.63333333333333,9.48,0.0002874802357337,14.5631313131313,14.5630810302278,14.5631012253236,5.81873994206135,-24,-28,0,0,-28,0,0,0,0,-2,0,-2,0,0,0,0,0,2,0,2,-1,-8,0,-10,-6,0.0053811659192825,-0.203100775193798,0.0692465708520604,-0.241602728047741,-0.104712041884817,0.947368421052632,-0.977759472817133,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","146/150","D:H",2.67848962960141,0.0202679102821361,1.15384949648317,2.3213509541454,1.86363317860697,294.488177945815,1.16325476548539,0.0174140488202037,1.75910024233227,1.16837785201846,760.989759542733,0.0158563003544608,"lineage2","dr_mutations_pyrazinamide","GLU",0,"ERR117454,0710Y-sc-2011-10-12T14:59:44Z-1289188","ERR117454","lineage2.2.1","ru","Russia,Samara","pnca_p.asp8glu","A","-","ASP","DA8","pnca_complex.pdb"
|
|
"D8G","L2;L4","PZA","D","D8",8,"G",NA,"MDR","DM","hydrophilic","hydrophobic","acidic","neutral","neg","non-polar",3.22,-3.445,-0.851,1.89305,-1.078,-0.82,92,95,-1.187,9,9,5,0.0259067357512953,"loop",1.63333333333333,9.48,0.0007905706482679,48.6872097931617,48.6872048041474,48.6746878162623,37.2619168572472,34,38,0,0,38,0,0,0,0,0,0,0,0,0,0,0,0,-8,-1,-3,-5,6,0,9,17,-0.872593718338399,-0.219896640826873,0.0689490016681357,-0.183802216538789,-0.214659685863874,0.968421052631579,-0.977759472817133,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","146/150","D:H",3.88541626053988,0.0002118075877291,1.0488367141091,3.70450062271154,9.3197738725557,893.78337229237,1.68741488635211,1.95392414212297e-07,6.70909230105579,6.91781679568266,2088.84994220519,1.03281930722422e-09,"lineage2;lineage4","dr_mutations_pyrazinamide","GLY",0,"SRR5818641","SRR5818641","lineage4;lineage2.2.1","dj","Djibouti","pnca_p.asp8gly","A","-","ASP","DA8","pnca_complex.pdb"
|
|
"D8G","L2","PZA","D","D8",8,"G",1,"Pre-XDR","DM","hydrophilic","hydrophobic","acidic","neutral","neg","non-polar",3.22,-3.445,-0.851,1.89305,-1.078,-0.82,92,95,-1.187,9,9,5,0.0259067357512953,"loop",1.63333333333333,9.48,0.0007905706482679,48.6872097931617,48.6872048041474,48.6746878162623,37.2619168572472,34,38,0,0,38,0,0,0,0,0,0,0,0,0,0,0,0,-8,-1,-3,-5,6,0,9,17,-0.872593718338399,-0.219896640826873,0.0689490016681357,-0.183802216538789,-0.214659685863874,0.968421052631579,-0.977759472817133,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","146/150","D:H",3.88541626053988,0.0002118075877291,1.0488367141091,3.70450062271154,9.3197738725557,893.78337229237,1.68741488635211,1.95392414212297e-07,6.70909230105579,6.91781679568266,2088.84994220519,1.03281930722422e-09,"lineage2","dr_mutations_pyrazinamide","GLY",0,"ERS2592737","ERR2677386","lineage2.2.1","de","Germany","pnca_p.asp8gly","A","-","ASP","DA8","pnca_complex.pdb"
|
|
"D8G","L2","PZA","D","D8",8,"G",1,"MDR","DM","hydrophilic","hydrophobic","acidic","neutral","neg","non-polar",3.22,-3.445,-0.851,1.89305,-1.078,-0.82,92,95,-1.187,9,9,5,0.0259067357512953,"loop",1.63333333333333,9.48,0.0007905706482679,48.6872097931617,48.6872048041474,48.6746878162623,37.2619168572472,34,38,0,0,38,0,0,0,0,0,0,0,0,0,0,0,0,-8,-1,-3,-5,6,0,9,17,-0.872593718338399,-0.219896640826873,0.0689490016681357,-0.183802216538789,-0.214659685863874,0.968421052631579,-0.977759472817133,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","146/150","D:H",3.88541626053988,0.0002118075877291,1.0488367141091,3.70450062271154,9.3197738725557,893.78337229237,1.68741488635211,1.95392414212297e-07,6.70909230105579,6.91781679568266,2088.84994220519,1.03281930722422e-09,"lineage2","dr_mutations_pyrazinamide","GLY",0,"ERR2517005","ERR2517005","lineage2.2.1","gb","UK","pnca_p.asp8gly","A","-","ASP","DA8","pnca_complex.pdb"
|
|
"D8G","L4","PZA","D","D8",8,"G",NA,"Pre-MDR","DM","hydrophilic","hydrophobic","acidic","neutral","neg","non-polar",3.22,-3.445,-0.851,1.89305,-1.078,-0.82,92,95,-1.187,9,9,5,0.0259067357512953,"loop",1.63333333333333,9.48,0.0007905706482679,48.6872097931617,48.6872048041474,48.6746878162623,37.2619168572472,34,38,0,0,38,0,0,0,0,0,0,0,0,0,0,0,0,-8,-1,-3,-5,6,0,9,17,-0.872593718338399,-0.219896640826873,0.0689490016681357,-0.183802216538789,-0.214659685863874,0.968421052631579,-0.977759472817133,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","146/150","D:H",3.88541626053988,0.0002118075877291,1.0488367141091,3.70450062271154,9.3197738725557,893.78337229237,1.68741488635211,1.95392414212297e-07,6.70909230105579,6.91781679568266,2088.84994220519,1.03281930722422e-09,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR1213926","ERR1213926","lineage4.1.2.1","ma","Morocco","pnca_p.asp8gly","A","-","ASP","DA8","pnca_complex.pdb"
|
|
"D8G","L2","PZA","D","D8",8,"G",1,"Pre-XDR","DM","hydrophilic","hydrophobic","acidic","neutral","neg","non-polar",3.22,-3.445,-0.851,1.89305,-1.078,-0.82,92,95,-1.187,9,9,5,0.0259067357512953,"loop",1.63333333333333,9.48,0.0007905706482679,48.6872097931617,48.6872048041474,48.6746878162623,37.2619168572472,34,38,0,0,38,0,0,0,0,0,0,0,0,0,0,0,0,-8,-1,-3,-5,6,0,9,17,-0.872593718338399,-0.219896640826873,0.0689490016681357,-0.183802216538789,-0.214659685863874,0.968421052631579,-0.977759472817133,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","146/150","D:H",3.88541626053988,0.0002118075877291,1.0488367141091,3.70450062271154,9.3197738725557,893.78337229237,1.68741488635211,1.95392414212297e-07,6.70909230105579,6.91781679568266,2088.84994220519,1.03281930722422e-09,"lineage2","dr_mutations_pyrazinamide","GLY",0,"ERS2592787","ERR2677441","lineage2.2.1","de","Germany","pnca_p.asp8gly","A","-","ASP","DA8","pnca_complex.pdb"
|
|
"D8G","L2","PZA","D","D8",8,"G",1,"MDR","DM","hydrophilic","hydrophobic","acidic","neutral","neg","non-polar",3.22,-3.445,-0.851,1.89305,-1.078,-0.82,92,95,-1.187,9,9,5,0.0259067357512953,"loop",1.63333333333333,9.48,0.0007905706482679,48.6872097931617,48.6872048041474,48.6746878162623,37.2619168572472,34,38,0,0,38,0,0,0,0,0,0,0,0,0,0,0,0,-8,-1,-3,-5,6,0,9,17,-0.872593718338399,-0.219896640826873,0.0689490016681357,-0.183802216538789,-0.214659685863874,0.968421052631579,-0.977759472817133,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","146/150","D:H",3.88541626053988,0.0002118075877291,1.0488367141091,3.70450062271154,9.3197738725557,893.78337229237,1.68741488635211,1.95392414212297e-07,6.70909230105579,6.91781679568266,2088.84994220519,1.03281930722422e-09,"lineage2","dr_mutations_pyrazinamide","GLY",0,"SAMN03648082,SRR2100909","SRR2100909","lineage2.2.1","","","pnca_p.asp8gly","A","-","ASP","DA8","pnca_complex.pdb"
|
|
"D8G","L2","PZA","D","D8",8,"G",1,"Pre-XDR","DM","hydrophilic","hydrophobic","acidic","neutral","neg","non-polar",3.22,-3.445,-0.851,1.89305,-1.078,-0.82,92,95,-1.187,9,9,5,0.0259067357512953,"loop",1.63333333333333,9.48,0.0007905706482679,48.6872097931617,48.6872048041474,48.6746878162623,37.2619168572472,34,38,0,0,38,0,0,0,0,0,0,0,0,0,0,0,0,-8,-1,-3,-5,6,0,9,17,-0.872593718338399,-0.219896640826873,0.0689490016681357,-0.183802216538789,-0.214659685863874,0.968421052631579,-0.977759472817133,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","146/150","D:H",3.88541626053988,0.0002118075877291,1.0488367141091,3.70450062271154,9.3197738725557,893.78337229237,1.68741488635211,1.95392414212297e-07,6.70909230105579,6.91781679568266,2088.84994220519,1.03281930722422e-09,"lineage2","dr_mutations_pyrazinamide","GLY",0,"ERS2592739","ERR2677389","lineage2.2.1","de","Germany","pnca_p.asp8gly","A","-","ASP","DA8","pnca_complex.pdb"
|
|
"D8G","L2","PZA","D","D8",8,"G",1,"MDR","DM","hydrophilic","hydrophobic","acidic","neutral","neg","non-polar",3.22,-3.445,-0.851,1.89305,-1.078,-0.82,92,95,-1.187,9,9,5,0.0259067357512953,"loop",1.63333333333333,9.48,0.0007905706482679,48.6872097931617,48.6872048041474,48.6746878162623,37.2619168572472,34,38,0,0,38,0,0,0,0,0,0,0,0,0,0,0,0,-8,-1,-3,-5,6,0,9,17,-0.872593718338399,-0.219896640826873,0.0689490016681357,-0.183802216538789,-0.214659685863874,0.968421052631579,-0.977759472817133,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","146/150","D:H",3.88541626053988,0.0002118075877291,1.0488367141091,3.70450062271154,9.3197738725557,893.78337229237,1.68741488635211,1.95392414212297e-07,6.70909230105579,6.91781679568266,2088.84994220519,1.03281930722422e-09,"lineage2","dr_mutations_pyrazinamide","GLY",0,"ERR2516875","ERR2516875","lineage2.2.1","gb","UK","pnca_p.asp8gly","A","-","ASP","DA8","pnca_complex.pdb"
|
|
"D8G","L4","PZA","D","D8",8,"G",NA,"MDR","DM","hydrophilic","hydrophobic","acidic","neutral","neg","non-polar",3.22,-3.445,-0.851,1.89305,-1.078,-0.82,92,95,-1.187,9,9,5,0.0259067357512953,"loop",1.63333333333333,9.48,0.0007905706482679,48.6872097931617,48.6872048041474,48.6746878162623,37.2619168572472,34,38,0,0,38,0,0,0,0,0,0,0,0,0,0,0,0,-8,-1,-3,-5,6,0,9,17,-0.872593718338399,-0.219896640826873,0.0689490016681357,-0.183802216538789,-0.214659685863874,0.968421052631579,-0.977759472817133,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","146/150","D:H",3.88541626053988,0.0002118075877291,1.0488367141091,3.70450062271154,9.3197738725557,893.78337229237,1.68741488635211,1.95392414212297e-07,6.70909230105579,6.91781679568266,2088.84994220519,1.03281930722422e-09,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR2706989","ERR2706989","lineage4.3.4.2","cd","Democratic Republic of Congo","pnca_p.asp8gly","A","-","ASP","DA8","pnca_complex.pdb"
|
|
"D8G","L2","PZA","D","D8",8,"G",NA,"MDR","DM","hydrophilic","hydrophobic","acidic","neutral","neg","non-polar",3.22,-3.445,-0.851,1.89305,-1.078,-0.82,92,95,-1.187,9,9,5,0.0259067357512953,"loop",1.63333333333333,9.48,0.0007905706482679,48.6872097931617,48.6872048041474,48.6746878162623,37.2619168572472,34,38,0,0,38,0,0,0,0,0,0,0,0,0,0,0,0,-8,-1,-3,-5,6,0,9,17,-0.872593718338399,-0.219896640826873,0.0689490016681357,-0.183802216538789,-0.214659685863874,0.968421052631579,-0.977759472817133,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","146/150","D:H",3.88541626053988,0.0002118075877291,1.0488367141091,3.70450062271154,9.3197738725557,893.78337229237,1.68741488635211,1.95392414212297e-07,6.70909230105579,6.91781679568266,2088.84994220519,1.03281930722422e-09,"lineage2","dr_mutations_pyrazinamide","GLY",0,"SAMN02414980","SRR1165480_SRR1165595_SRR1163032_SRR1162843","lineage2.2.1","se","Sweden","pnca_p.asp8gly","A","-","ASP","DA8","pnca_complex.pdb"
|
|
"D8G","L2","PZA","D","D8",8,"G",1,"MDR","DM","hydrophilic","hydrophobic","acidic","neutral","neg","non-polar",3.22,-3.445,-0.851,1.89305,-1.078,-0.82,92,95,-1.187,9,9,5,0.0259067357512953,"loop",1.63333333333333,9.48,0.0007905706482679,48.6872097931617,48.6872048041474,48.6746878162623,37.2619168572472,34,38,0,0,38,0,0,0,0,0,0,0,0,0,0,0,0,-8,-1,-3,-5,6,0,9,17,-0.872593718338399,-0.219896640826873,0.0689490016681357,-0.183802216538789,-0.214659685863874,0.968421052631579,-0.977759472817133,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","146/150","D:H",3.88541626053988,0.0002118075877291,1.0488367141091,3.70450062271154,9.3197738725557,893.78337229237,1.68741488635211,1.95392414212297e-07,6.70909230105579,6.91781679568266,2088.84994220519,1.03281930722422e-09,"lineage2","dr_mutations_pyrazinamide","GLY",0,"ERR2517015","ERR2517015","lineage2.2.1","gb","UK","pnca_p.asp8gly","A","-","ASP","DA8","pnca_complex.pdb"
|
|
"D8G","L2","PZA","D","D8",8,"G",1,"Pre-XDR","DM","hydrophilic","hydrophobic","acidic","neutral","neg","non-polar",3.22,-3.445,-0.851,1.89305,-1.078,-0.82,92,95,-1.187,9,9,5,0.0259067357512953,"loop",1.63333333333333,9.48,0.0007905706482679,48.6872097931617,48.6872048041474,48.6746878162623,37.2619168572472,34,38,0,0,38,0,0,0,0,0,0,0,0,0,0,0,0,-8,-1,-3,-5,6,0,9,17,-0.872593718338399,-0.219896640826873,0.0689490016681357,-0.183802216538789,-0.214659685863874,0.968421052631579,-0.977759472817133,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","146/150","D:H",3.88541626053988,0.0002118075877291,1.0488367141091,3.70450062271154,9.3197738725557,893.78337229237,1.68741488635211,1.95392414212297e-07,6.70909230105579,6.91781679568266,2088.84994220519,1.03281930722422e-09,"lineage2","dr_mutations_pyrazinamide","GLY",0,"ERR2516213","ERR2516213","lineage2.2.1","be","Belgium","pnca_p.asp8gly","A","-","ASP","DA8","pnca_complex.pdb"
|
|
"D8G","L2","PZA","D","D8",8,"G",NA,"MDR","DM","hydrophilic","hydrophobic","acidic","neutral","neg","non-polar",3.22,-3.445,-0.851,1.89305,-1.078,-0.82,92,95,-1.187,9,9,5,0.0259067357512953,"loop",1.63333333333333,9.48,0.0007905706482679,48.6872097931617,48.6872048041474,48.6746878162623,37.2619168572472,34,38,0,0,38,0,0,0,0,0,0,0,0,0,0,0,0,-8,-1,-3,-5,6,0,9,17,-0.872593718338399,-0.219896640826873,0.0689490016681357,-0.183802216538789,-0.214659685863874,0.968421052631579,-0.977759472817133,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","146/150","D:H",3.88541626053988,0.0002118075877291,1.0488367141091,3.70450062271154,9.3197738725557,893.78337229237,1.68741488635211,1.95392414212297e-07,6.70909230105579,6.91781679568266,2088.84994220519,1.03281930722422e-09,"lineage2","dr_mutations_pyrazinamide","GLY",0,"SRR8380894","SRR8380894","lineage2.2.1","in","India","pnca_p.asp8gly","A","-","ASP","DA8","pnca_complex.pdb"
|
|
"D8G","L2","PZA","D","D8",8,"G",1,"MDR","DM","hydrophilic","hydrophobic","acidic","neutral","neg","non-polar",3.22,-3.445,-0.851,1.89305,-1.078,-0.82,92,95,-1.187,9,9,5,0.0259067357512953,"loop",1.63333333333333,9.48,0.0007905706482679,48.6872097931617,48.6872048041474,48.6746878162623,37.2619168572472,34,38,0,0,38,0,0,0,0,0,0,0,0,0,0,0,0,-8,-1,-3,-5,6,0,9,17,-0.872593718338399,-0.219896640826873,0.0689490016681357,-0.183802216538789,-0.214659685863874,0.968421052631579,-0.977759472817133,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","146/150","D:H",3.88541626053988,0.0002118075877291,1.0488367141091,3.70450062271154,9.3197738725557,893.78337229237,1.68741488635211,1.95392414212297e-07,6.70909230105579,6.91781679568266,2088.84994220519,1.03281930722422e-09,"lineage2","dr_mutations_pyrazinamide","GLY",0,"ERR2512979","ERR2512979","lineage2.2.1","gb","UK","pnca_p.asp8gly","A","-","ASP","DA8","pnca_complex.pdb"
|
|
"D8G","L2","PZA","D","D8",8,"G",NA,"Pre-MDR","DM","hydrophilic","hydrophobic","acidic","neutral","neg","non-polar",3.22,-3.445,-0.851,1.89305,-1.078,-0.82,92,95,-1.187,9,9,5,0.0259067357512953,"loop",1.63333333333333,9.48,0.0007905706482679,48.6872097931617,48.6872048041474,48.6746878162623,37.2619168572472,34,38,0,0,38,0,0,0,0,0,0,0,0,0,0,0,0,-8,-1,-3,-5,6,0,9,17,-0.872593718338399,-0.219896640826873,0.0689490016681357,-0.183802216538789,-0.214659685863874,0.968421052631579,-0.977759472817133,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","146/150","D:H",3.88541626053988,0.0002118075877291,1.0488367141091,3.70450062271154,9.3197738725557,893.78337229237,1.68741488635211,1.95392414212297e-07,6.70909230105579,6.91781679568266,2088.84994220519,1.03281930722422e-09,"lineage2","dr_mutations_pyrazinamide","GLY",0,"BGI_C-xz06202,SRR671728","SRR671728","lineage2.2.1","cn","China","pnca_p.asp8gly","A","-","ASP","DA8","pnca_complex.pdb"
|
|
"D8G","L4","PZA","D","D8",8,"G",0,"MDR","DM","hydrophilic","hydrophobic","acidic","neutral","neg","non-polar",3.22,-3.445,-0.851,1.89305,-1.078,-0.82,92,95,-1.187,9,9,5,0.0259067357512953,"loop",1.63333333333333,9.48,0.0007905706482679,48.6872097931617,48.6872048041474,48.6746878162623,37.2619168572472,34,38,0,0,38,0,0,0,0,0,0,0,0,0,0,0,0,-8,-1,-3,-5,6,0,9,17,-0.872593718338399,-0.219896640826873,0.0689490016681357,-0.183802216538789,-0.214659685863874,0.968421052631579,-0.977759472817133,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","146/150","D:H",3.88541626053988,0.0002118075877291,1.0488367141091,3.70450062271154,9.3197738725557,893.78337229237,1.68741488635211,1.95392414212297e-07,6.70909230105579,6.91781679568266,2088.84994220519,1.03281930722422e-09,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR2516605","ERR2516605","lineage4.1.1.3","pe","Peru","pnca_p.asp8gly","A","-","ASP","DA8","pnca_complex.pdb"
|
|
"D8G","L2","PZA","D","D8",8,"G",1,"Pre-XDR","DM","hydrophilic","hydrophobic","acidic","neutral","neg","non-polar",3.22,-3.445,-0.851,1.89305,-1.078,-0.82,92,95,-1.187,9,9,5,0.0259067357512953,"loop",1.63333333333333,9.48,0.0007905706482679,48.6872097931617,48.6872048041474,48.6746878162623,37.2619168572472,34,38,0,0,38,0,0,0,0,0,0,0,0,0,0,0,0,-8,-1,-3,-5,6,0,9,17,-0.872593718338399,-0.219896640826873,0.0689490016681357,-0.183802216538789,-0.214659685863874,0.968421052631579,-0.977759472817133,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","146/150","D:H",3.88541626053988,0.0002118075877291,1.0488367141091,3.70450062271154,9.3197738725557,893.78337229237,1.68741488635211,1.95392414212297e-07,6.70909230105579,6.91781679568266,2088.84994220519,1.03281930722422e-09,"lineage2","dr_mutations_pyrazinamide","GLY",0,"ERR2510798","ERR2510798","lineage2.2.1","it","Italy","pnca_p.asp8gly","A","-","ASP","DA8","pnca_complex.pdb"
|
|
"D8G","L4","PZA","D","D8",8,"G",NA,"MDR","DM","hydrophilic","hydrophobic","acidic","neutral","neg","non-polar",3.22,-3.445,-0.851,1.89305,-1.078,-0.82,92,95,-1.187,9,9,5,0.0259067357512953,"loop",1.63333333333333,9.48,0.0007905706482679,48.6872097931617,48.6872048041474,48.6746878162623,37.2619168572472,34,38,0,0,38,0,0,0,0,0,0,0,0,0,0,0,0,-8,-1,-3,-5,6,0,9,17,-0.872593718338399,-0.219896640826873,0.0689490016681357,-0.183802216538789,-0.214659685863874,0.968421052631579,-0.977759472817133,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","146/150","D:H",3.88541626053988,0.0002118075877291,1.0488367141091,3.70450062271154,9.3197738725557,893.78337229237,1.68741488635211,1.95392414212297e-07,6.70909230105579,6.91781679568266,2088.84994220519,1.03281930722422e-09,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR2707209","ERR2707209","lineage4.3.4.2","cd","Democratic Republic of Congo","pnca_p.asp8gly","A","-","ASP","DA8","pnca_complex.pdb"
|
|
"D8N","L2","PZA","D","D8",8,"N",NA,"MDR","DM","hydrophilic","hydrophilic","acidic","neutral","neg","polar",3.22,-1.655,-1.182,-1.26057,-1.022,-1.29,92,95,-1.187,9,9,5,0.0259067357512953,"loop",1.63333333333333,9.48,0.0005030904125341,29.1630847029077,29.1630732435187,29.1293325978315,18.6717493808583,0,34,0,0,34,0,0,0,0,-4,0,-2,-2,0,0,0,0,-7,0,-5,-4,0,0,-4,2,-0.41919959473151,-0.305426356589147,-0.242361378143505,-0.174254049445865,-0.337696335078534,0.968421052631579,-0.977759472817133,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","146/150","D:H",3.37290329402598,0.001789077082818,1.07995768762031,3.12318096596746,4.97876379054103,550.894323519252,1.46483345924118,0.0001485295621003,3.828187099348,3.53443753556636,1331.56873199938,1.55265977742841e-05,"lineage2","dr_mutations_pyrazinamide","ASN",0,"ERR2515173","ERR2515173","lineage2.2.1","za","South Africa","pnca_p.asp8asn","A","-","ASP","DA8","pnca_complex.pdb"
|
|
"D8N","L2","PZA","D","D8",8,"N",NA,"XDR","DM","hydrophilic","hydrophilic","acidic","neutral","neg","polar",3.22,-1.655,-1.182,-1.26057,-1.022,-1.29,92,95,-1.187,9,9,5,0.0259067357512953,"loop",1.63333333333333,9.48,0.0005030904125341,29.1630847029077,29.1630732435187,29.1293325978315,18.6717493808583,0,34,0,0,34,0,0,0,0,-4,0,-2,-2,0,0,0,0,-7,0,-5,-4,0,0,-4,2,-0.41919959473151,-0.305426356589147,-0.242361378143505,-0.174254049445865,-0.337696335078534,0.968421052631579,-0.977759472817133,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","146/150","D:H",3.37290329402598,0.001789077082818,1.07995768762031,3.12318096596746,4.97876379054103,550.894323519252,1.46483345924118,0.0001485295621003,3.828187099348,3.53443753556636,1331.56873199938,1.55265977742841e-05,"lineage2","dr_mutations_pyrazinamide","ASN",0,"ERR1035078","ERR1035078","lineage2.2.1","za","South Africa","pnca_p.asp8asn","A","-","ASP","DA8","pnca_complex.pdb"
|
|
"D8N","L2","PZA","D","D8",8,"N",NA,"XDR","DM","hydrophilic","hydrophilic","acidic","neutral","neg","polar",3.22,-1.655,-1.182,-1.26057,-1.022,-1.29,92,95,-1.187,9,9,5,0.0259067357512953,"loop",1.63333333333333,9.48,0.0005030904125341,29.1630847029077,29.1630732435187,29.1293325978315,18.6717493808583,0,34,0,0,34,0,0,0,0,-4,0,-2,-2,0,0,0,0,-7,0,-5,-4,0,0,-4,2,-0.41919959473151,-0.305426356589147,-0.242361378143505,-0.174254049445865,-0.337696335078534,0.968421052631579,-0.977759472817133,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","146/150","D:H",3.37290329402598,0.001789077082818,1.07995768762031,3.12318096596746,4.97876379054103,550.894323519252,1.46483345924118,0.0001485295621003,3.828187099348,3.53443753556636,1331.56873199938,1.55265977742841e-05,"lineage2","dr_mutations_pyrazinamide","ASN",0,"SAMN02419565","SRR1181019_SRR1184035_SRR1159738_SRR1159790","lineage2.2.1","by","Belarus","pnca_p.asp8asn","A","-","ASP","DA8","pnca_complex.pdb"
|
|
"D8N","L2","PZA","D","D8",8,"N",NA,"XDR","DM","hydrophilic","hydrophilic","acidic","neutral","neg","polar",3.22,-1.655,-1.182,-1.26057,-1.022,-1.29,92,95,-1.187,9,9,5,0.0259067357512953,"loop",1.63333333333333,9.48,0.0005030904125341,29.1630847029077,29.1630732435187,29.1293325978315,18.6717493808583,0,34,0,0,34,0,0,0,0,-4,0,-2,-2,0,0,0,0,-7,0,-5,-4,0,0,-4,2,-0.41919959473151,-0.305426356589147,-0.242361378143505,-0.174254049445865,-0.337696335078534,0.968421052631579,-0.977759472817133,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","146/150","D:H",3.37290329402598,0.001789077082818,1.07995768762031,3.12318096596746,4.97876379054103,550.894323519252,1.46483345924118,0.0001485295621003,3.828187099348,3.53443753556636,1331.56873199938,1.55265977742841e-05,"lineage2","dr_mutations_pyrazinamide","ASN",0,"SAMN02419602","SRR1184123_SRR1180984_SRR1159362_SRR1159122","lineage2.2.1","by","Belarus","pnca_p.asp8asn","A","-","ASP","DA8","pnca_complex.pdb"
|
|
"D8N","L2","PZA","D","D8",8,"N",0,"Pre-XDR","DM","hydrophilic","hydrophilic","acidic","neutral","neg","polar",3.22,-1.655,-1.182,-1.26057,-1.022,-1.29,92,95,-1.187,9,9,5,0.0259067357512953,"loop",1.63333333333333,9.48,0.0005030904125341,29.1630847029077,29.1630732435187,29.1293325978315,18.6717493808583,0,34,0,0,34,0,0,0,0,-4,0,-2,-2,0,0,0,0,-7,0,-5,-4,0,0,-4,2,-0.41919959473151,-0.305426356589147,-0.242361378143505,-0.174254049445865,-0.337696335078534,0.968421052631579,-0.977759472817133,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","146/150","D:H",3.37290329402598,0.001789077082818,1.07995768762031,3.12318096596746,4.97876379054103,550.894323519252,1.46483345924118,0.0001485295621003,3.828187099348,3.53443753556636,1331.56873199938,1.55265977742841e-05,"lineage2","dr_mutations_pyrazinamide","ASN",0,"ERR2515304","ERR2515304","lineage2.2.1","za","South Africa","pnca_p.asp8asn","A","-","ASP","DA8","pnca_complex.pdb"
|
|
"D8N","L2","PZA","D","D8",8,"N",NA,"XDR","DM","hydrophilic","hydrophilic","acidic","neutral","neg","polar",3.22,-1.655,-1.182,-1.26057,-1.022,-1.29,92,95,-1.187,9,9,5,0.0259067357512953,"loop",1.63333333333333,9.48,0.0005030904125341,29.1630847029077,29.1630732435187,29.1293325978315,18.6717493808583,0,34,0,0,34,0,0,0,0,-4,0,-2,-2,0,0,0,0,-7,0,-5,-4,0,0,-4,2,-0.41919959473151,-0.305426356589147,-0.242361378143505,-0.174254049445865,-0.337696335078534,0.968421052631579,-0.977759472817133,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","146/150","D:H",3.37290329402598,0.001789077082818,1.07995768762031,3.12318096596746,4.97876379054103,550.894323519252,1.46483345924118,0.0001485295621003,3.828187099348,3.53443753556636,1331.56873199938,1.55265977742841e-05,"lineage2","dr_mutations_pyrazinamide","ASN",0,"ERR2515589","ERR2515589","lineage2.2.1","za","South Africa","pnca_p.asp8asn","A","-","ASP","DA8","pnca_complex.pdb"
|
|
"D8N","L4","PZA","D","D8",8,"N",NA,"MDR","DM","hydrophilic","hydrophilic","acidic","neutral","neg","polar",3.22,-1.655,-1.182,-1.26057,-1.022,-1.29,92,95,-1.187,9,9,5,0.0259067357512953,"loop",1.63333333333333,9.48,0.0005030904125341,29.1630847029077,29.1630732435187,29.1293325978315,18.6717493808583,0,34,0,0,34,0,0,0,0,-4,0,-2,-2,0,0,0,0,-7,0,-5,-4,0,0,-4,2,-0.41919959473151,-0.305426356589147,-0.242361378143505,-0.174254049445865,-0.337696335078534,0.968421052631579,-0.977759472817133,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","146/150","D:H",3.37290329402598,0.001789077082818,1.07995768762031,3.12318096596746,4.97876379054103,550.894323519252,1.46483345924118,0.0001485295621003,3.828187099348,3.53443753556636,1331.56873199938,1.55265977742841e-05,"lineage4","dr_mutations_pyrazinamide","ASN",0,"SAMN02414918","SRR1144735_SRR1163015_SRR1146421_SRR1163040","lineage4.7","se","Sweden","pnca_p.asp8asn","A","-","ASP","DA8","pnca_complex.pdb"
|
|
"D8N","L2","PZA","D","D8",8,"N",NA,"MDR","DM","hydrophilic","hydrophilic","acidic","neutral","neg","polar",3.22,-1.655,-1.182,-1.26057,-1.022,-1.29,92,95,-1.187,9,9,5,0.0259067357512953,"loop",1.63333333333333,9.48,0.0005030904125341,29.1630847029077,29.1630732435187,29.1293325978315,18.6717493808583,0,34,0,0,34,0,0,0,0,-4,0,-2,-2,0,0,0,0,-7,0,-5,-4,0,0,-4,2,-0.41919959473151,-0.305426356589147,-0.242361378143505,-0.174254049445865,-0.337696335078534,0.968421052631579,-0.977759472817133,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","146/150","D:H",3.37290329402598,0.001789077082818,1.07995768762031,3.12318096596746,4.97876379054103,550.894323519252,1.46483345924118,0.0001485295621003,3.828187099348,3.53443753556636,1331.56873199938,1.55265977742841e-05,"lineage2","dr_mutations_pyrazinamide","ASN",0,"ERR2515650","ERR2515650","lineage2.2.1","za","South Africa","pnca_p.asp8asn","A","-","ASP","DA8","pnca_complex.pdb"
|
|
"D8N","L4","PZA","D","D8",8,"N",1,"Other","DM","hydrophilic","hydrophilic","acidic","neutral","neg","polar",3.22,-1.655,-1.182,-1.26057,-1.022,-1.29,92,95,-1.187,9,9,5,0.0259067357512953,"loop",1.63333333333333,9.48,0.0005030904125341,29.1630847029077,29.1630732435187,29.1293325978315,18.6717493808583,0,34,0,0,34,0,0,0,0,-4,0,-2,-2,0,0,0,0,-7,0,-5,-4,0,0,-4,2,-0.41919959473151,-0.305426356589147,-0.242361378143505,-0.174254049445865,-0.337696335078534,0.968421052631579,-0.977759472817133,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","146/150","D:H",3.37290329402598,0.001789077082818,1.07995768762031,3.12318096596746,4.97876379054103,550.894323519252,1.46483345924118,0.0001485295621003,3.828187099348,3.53443753556636,1331.56873199938,1.55265977742841e-05,"lineage4","dr_mutations_pyrazinamide","ASN",0,"SRR2100844,SAMN03648017","SRR2100844","lineage4.2.1","","","pnca_p.asp8asn","A","-","ASP","DA8","pnca_complex.pdb"
|
|
"D8N","L2","PZA","D","D8",8,"N",NA,"Pre-XDR","DM","hydrophilic","hydrophilic","acidic","neutral","neg","polar",3.22,-1.655,-1.182,-1.26057,-1.022,-1.29,92,95,-1.187,9,9,5,0.0259067357512953,"loop",1.63333333333333,9.48,0.0005030904125341,29.1630847029077,29.1630732435187,29.1293325978315,18.6717493808583,0,34,0,0,34,0,0,0,0,-4,0,-2,-2,0,0,0,0,-7,0,-5,-4,0,0,-4,2,-0.41919959473151,-0.305426356589147,-0.242361378143505,-0.174254049445865,-0.337696335078534,0.968421052631579,-0.977759472817133,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","146/150","D:H",3.37290329402598,0.001789077082818,1.07995768762031,3.12318096596746,4.97876379054103,550.894323519252,1.46483345924118,0.0001485295621003,3.828187099348,3.53443753556636,1331.56873199938,1.55265977742841e-05,"lineage2","dr_mutations_pyrazinamide","ASN",0,"SAMN02419547","SRR1162485_SRR1181247_SRR1159044_SRR1181045","lineage2.2.1","by","Belarus","pnca_p.asp8asn","A","-","ASP","DA8","pnca_complex.pdb"
|
|
"D8N","L2","PZA","D","D8",8,"N",1,"Pre-XDR","DM","hydrophilic","hydrophilic","acidic","neutral","neg","polar",3.22,-1.655,-1.182,-1.26057,-1.022,-1.29,92,95,-1.187,9,9,5,0.0259067357512953,"loop",1.63333333333333,9.48,0.0005030904125341,29.1630847029077,29.1630732435187,29.1293325978315,18.6717493808583,0,34,0,0,34,0,0,0,0,-4,0,-2,-2,0,0,0,0,-7,0,-5,-4,0,0,-4,2,-0.41919959473151,-0.305426356589147,-0.242361378143505,-0.174254049445865,-0.337696335078534,0.968421052631579,-0.977759472817133,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","146/150","D:H",3.37290329402598,0.001789077082818,1.07995768762031,3.12318096596746,4.97876379054103,550.894323519252,1.46483345924118,0.0001485295621003,3.828187099348,3.53443753556636,1331.56873199938,1.55265977742841e-05,"lineage2","dr_mutations_pyrazinamide","ASN",0,"ERR1873471","ERR1873471","lineage2.2.1","za","South Africa","pnca_p.asp8asn","A","-","ASP","DA8","pnca_complex.pdb"
|
|
"D8N","L2","PZA","D","D8",8,"N",1,"MDR","DM","hydrophilic","hydrophilic","acidic","neutral","neg","polar",3.22,-1.655,-1.182,-1.26057,-1.022,-1.29,92,95,-1.187,9,9,5,0.0259067357512953,"loop",1.63333333333333,9.48,0.0005030904125341,29.1630847029077,29.1630732435187,29.1293325978315,18.6717493808583,0,34,0,0,34,0,0,0,0,-4,0,-2,-2,0,0,0,0,-7,0,-5,-4,0,0,-4,2,-0.41919959473151,-0.305426356589147,-0.242361378143505,-0.174254049445865,-0.337696335078534,0.968421052631579,-0.977759472817133,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","146/150","D:H",3.37290329402598,0.001789077082818,1.07995768762031,3.12318096596746,4.97876379054103,550.894323519252,1.46483345924118,0.0001485295621003,3.828187099348,3.53443753556636,1331.56873199938,1.55265977742841e-05,"lineage2","dr_mutations_pyrazinamide","ASN",0,"ERR2515488","ERR2515488","lineage2.2.1","za","South Africa","pnca_p.asp8asn","A","-","ASP","DA8","pnca_complex.pdb"
|
|
"D8N","L4","PZA","D","D8",8,"N",NA,"MDR","DM","hydrophilic","hydrophilic","acidic","neutral","neg","polar",3.22,-1.655,-1.182,-1.26057,-1.022,-1.29,92,95,-1.187,9,9,5,0.0259067357512953,"loop",1.63333333333333,9.48,0.0005030904125341,29.1630847029077,29.1630732435187,29.1293325978315,18.6717493808583,0,34,0,0,34,0,0,0,0,-4,0,-2,-2,0,0,0,0,-7,0,-5,-4,0,0,-4,2,-0.41919959473151,-0.305426356589147,-0.242361378143505,-0.174254049445865,-0.337696335078534,0.968421052631579,-0.977759472817133,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","146/150","D:H",3.37290329402598,0.001789077082818,1.07995768762031,3.12318096596746,4.97876379054103,550.894323519252,1.46483345924118,0.0001485295621003,3.828187099348,3.53443753556636,1331.56873199938,1.55265977742841e-05,"lineage4","dr_mutations_pyrazinamide","ASN",0,"SAMN02414940","SRR1167141_SRR1165398_SRR1166914_SRR1162835","lineage4.7","se","Sweden","pnca_p.asp8asn","A","-","ASP","DA8","pnca_complex.pdb"
|
|
"D8N","L4","PZA","D","D8",8,"N",NA,"MDR","DM","hydrophilic","hydrophilic","acidic","neutral","neg","polar",3.22,-1.655,-1.182,-1.26057,-1.022,-1.29,92,95,-1.187,9,9,5,0.0259067357512953,"loop",1.63333333333333,9.48,0.0005030904125341,29.1630847029077,29.1630732435187,29.1293325978315,18.6717493808583,0,34,0,0,34,0,0,0,0,-4,0,-2,-2,0,0,0,0,-7,0,-5,-4,0,0,-4,2,-0.41919959473151,-0.305426356589147,-0.242361378143505,-0.174254049445865,-0.337696335078534,0.968421052631579,-0.977759472817133,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","146/150","D:H",3.37290329402598,0.001789077082818,1.07995768762031,3.12318096596746,4.97876379054103,550.894323519252,1.46483345924118,0.0001485295621003,3.828187099348,3.53443753556636,1331.56873199938,1.55265977742841e-05,"lineage4","dr_mutations_pyrazinamide","ASN",0,"ERR1023402","ERR1023402","lineage4.7","","","pnca_p.asp8asn","A","-","ASP","DA8","pnca_complex.pdb"
|
|
"D8N","L2","PZA","D","D8",8,"N",NA,"Pre-XDR","DM","hydrophilic","hydrophilic","acidic","neutral","neg","polar",3.22,-1.655,-1.182,-1.26057,-1.022,-1.29,92,95,-1.187,9,9,5,0.0259067357512953,"loop",1.63333333333333,9.48,0.0005030904125341,29.1630847029077,29.1630732435187,29.1293325978315,18.6717493808583,0,34,0,0,34,0,0,0,0,-4,0,-2,-2,0,0,0,0,-7,0,-5,-4,0,0,-4,2,-0.41919959473151,-0.305426356589147,-0.242361378143505,-0.174254049445865,-0.337696335078534,0.968421052631579,-0.977759472817133,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","146/150","D:H",3.37290329402598,0.001789077082818,1.07995768762031,3.12318096596746,4.97876379054103,550.894323519252,1.46483345924118,0.0001485295621003,3.828187099348,3.53443753556636,1331.56873199938,1.55265977742841e-05,"lineage2","dr_mutations_pyrazinamide","ASN",0,"ERR1035076","ERR1035076","lineage2.2.1","za","South Africa","pnca_p.asp8asn","A","-","ASP","DA8","pnca_complex.pdb"
|
|
"D8N","L2","PZA","D","D8",8,"N",NA,"MDR","DM","hydrophilic","hydrophilic","acidic","neutral","neg","polar",3.22,-1.655,-1.182,-1.26057,-1.022,-1.29,92,95,-1.187,9,9,5,0.0259067357512953,"loop",1.63333333333333,9.48,0.0005030904125341,29.1630847029077,29.1630732435187,29.1293325978315,18.6717493808583,0,34,0,0,34,0,0,0,0,-4,0,-2,-2,0,0,0,0,-7,0,-5,-4,0,0,-4,2,-0.41919959473151,-0.305426356589147,-0.242361378143505,-0.174254049445865,-0.337696335078534,0.968421052631579,-0.977759472817133,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","146/150","D:H",3.37290329402598,0.001789077082818,1.07995768762031,3.12318096596746,4.97876379054103,550.894323519252,1.46483345924118,0.0001485295621003,3.828187099348,3.53443753556636,1331.56873199938,1.55265977742841e-05,"lineage2","dr_mutations_pyrazinamide","ASN",0,"ERR1633956","ERR1633956","lineage2.2.1","za","South Africa","pnca_p.asp8asn","A","-","ASP","DA8","pnca_complex.pdb"
|
|
"D8N","L2","PZA","D","D8",8,"N",1,"XDR","DM","hydrophilic","hydrophilic","acidic","neutral","neg","polar",3.22,-1.655,-1.182,-1.26057,-1.022,-1.29,92,95,-1.187,9,9,5,0.0259067357512953,"loop",1.63333333333333,9.48,0.0005030904125341,29.1630847029077,29.1630732435187,29.1293325978315,18.6717493808583,0,34,0,0,34,0,0,0,0,-4,0,-2,-2,0,0,0,0,-7,0,-5,-4,0,0,-4,2,-0.41919959473151,-0.305426356589147,-0.242361378143505,-0.174254049445865,-0.337696335078534,0.968421052631579,-0.977759472817133,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","146/150","D:H",3.37290329402598,0.001789077082818,1.07995768762031,3.12318096596746,4.97876379054103,550.894323519252,1.46483345924118,0.0001485295621003,3.828187099348,3.53443753556636,1331.56873199938,1.55265977742841e-05,"lineage2","dr_mutations_pyrazinamide","ASN",0,"ERR1873477","ERR1873477","lineage2.2.1","za","South Africa","pnca_p.asp8asn","A","-","ASP","DA8","pnca_complex.pdb"
|
|
"D8N","L2","PZA","D","D8",8,"N",NA,"XDR","DM","hydrophilic","hydrophilic","acidic","neutral","neg","polar",3.22,-1.655,-1.182,-1.26057,-1.022,-1.29,92,95,-1.187,9,9,5,0.0259067357512953,"loop",1.63333333333333,9.48,0.0005030904125341,29.1630847029077,29.1630732435187,29.1293325978315,18.6717493808583,0,34,0,0,34,0,0,0,0,-4,0,-2,-2,0,0,0,0,-7,0,-5,-4,0,0,-4,2,-0.41919959473151,-0.305426356589147,-0.242361378143505,-0.174254049445865,-0.337696335078534,0.968421052631579,-0.977759472817133,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","146/150","D:H",3.37290329402598,0.001789077082818,1.07995768762031,3.12318096596746,4.97876379054103,550.894323519252,1.46483345924118,0.0001485295621003,3.828187099348,3.53443753556636,1331.56873199938,1.55265977742841e-05,"lineage2","dr_mutations_pyrazinamide","ASN",0,"SAMN02419587","SRR1162498_SRR1181007_SRR1183663_SRR1158950","lineage2.2.1","by","Belarus","pnca_p.asp8asn","A","-","ASP","DA8","pnca_complex.pdb"
|
|
"D8N","L2","PZA","D","D8",8,"N",NA,"MDR","DM","hydrophilic","hydrophilic","acidic","neutral","neg","polar",3.22,-1.655,-1.182,-1.26057,-1.022,-1.29,92,95,-1.187,9,9,5,0.0259067357512953,"loop",1.63333333333333,9.48,0.0005030904125341,29.1630847029077,29.1630732435187,29.1293325978315,18.6717493808583,0,34,0,0,34,0,0,0,0,-4,0,-2,-2,0,0,0,0,-7,0,-5,-4,0,0,-4,2,-0.41919959473151,-0.305426356589147,-0.242361378143505,-0.174254049445865,-0.337696335078534,0.968421052631579,-0.977759472817133,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","146/150","D:H",3.37290329402598,0.001789077082818,1.07995768762031,3.12318096596746,4.97876379054103,550.894323519252,1.46483345924118,0.0001485295621003,3.828187099348,3.53443753556636,1331.56873199938,1.55265977742841e-05,"lineage2","dr_mutations_pyrazinamide","ASN",0,"ERR1023521","ERR1023521","lineage2.2.1","","","pnca_p.asp8asn","A","-","ASP","DA8","pnca_complex.pdb"
|
|
"D8N","L4","PZA","D","D8",8,"N",NA,"Pre-XDR","DM","hydrophilic","hydrophilic","acidic","neutral","neg","polar",3.22,-1.655,-1.182,-1.26057,-1.022,-1.29,92,95,-1.187,9,9,5,0.0259067357512953,"loop",1.63333333333333,9.48,0.0005030904125341,29.1630847029077,29.1630732435187,29.1293325978315,18.6717493808583,0,34,0,0,34,0,0,0,0,-4,0,-2,-2,0,0,0,0,-7,0,-5,-4,0,0,-4,2,-0.41919959473151,-0.305426356589147,-0.242361378143505,-0.174254049445865,-0.337696335078534,0.968421052631579,-0.977759472817133,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","146/150","D:H",3.37290329402598,0.001789077082818,1.07995768762031,3.12318096596746,4.97876379054103,550.894323519252,1.46483345924118,0.0001485295621003,3.828187099348,3.53443753556636,1331.56873199938,1.55265977742841e-05,"lineage4","dr_mutations_pyrazinamide","ASN",0,"ERR1193843","ERR1193843","lineage4.3","iq","Iraq","pnca_p.asp8asn","A","-","ASP","DA8","pnca_complex.pdb"
|
|
"D8N","L2","PZA","D","D8",8,"N",NA,"MDR","DM","hydrophilic","hydrophilic","acidic","neutral","neg","polar",3.22,-1.655,-1.182,-1.26057,-1.022,-1.29,92,95,-1.187,9,9,5,0.0259067357512953,"loop",1.63333333333333,9.48,0.0005030904125341,29.1630847029077,29.1630732435187,29.1293325978315,18.6717493808583,0,34,0,0,34,0,0,0,0,-4,0,-2,-2,0,0,0,0,-7,0,-5,-4,0,0,-4,2,-0.41919959473151,-0.305426356589147,-0.242361378143505,-0.174254049445865,-0.337696335078534,0.968421052631579,-0.977759472817133,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","146/150","D:H",3.37290329402598,0.001789077082818,1.07995768762031,3.12318096596746,4.97876379054103,550.894323519252,1.46483345924118,0.0001485295621003,3.828187099348,3.53443753556636,1331.56873199938,1.55265977742841e-05,"lineage2","dr_mutations_pyrazinamide","ASN",0,"ERR1633964","ERR1633964","lineage2.2.1","za","South Africa","pnca_p.asp8asn","A","-","ASP","DA8","pnca_complex.pdb"
|
|
"D8N","L4","PZA","D","D8",8,"N",NA,"MDR","DM","hydrophilic","hydrophilic","acidic","neutral","neg","polar",3.22,-1.655,-1.182,-1.26057,-1.022,-1.29,92,95,-1.187,9,9,5,0.0259067357512953,"loop",1.63333333333333,9.48,0.0005030904125341,29.1630847029077,29.1630732435187,29.1293325978315,18.6717493808583,0,34,0,0,34,0,0,0,0,-4,0,-2,-2,0,0,0,0,-7,0,-5,-4,0,0,-4,2,-0.41919959473151,-0.305426356589147,-0.242361378143505,-0.174254049445865,-0.337696335078534,0.968421052631579,-0.977759472817133,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","146/150","D:H",3.37290329402598,0.001789077082818,1.07995768762031,3.12318096596746,4.97876379054103,550.894323519252,1.46483345924118,0.0001485295621003,3.828187099348,3.53443753556636,1331.56873199938,1.55265977742841e-05,"lineage4","dr_mutations_pyrazinamide","ASN",0,"SAMN02414943","SRR1167090_SRR1162750_SRR1166808_SRR1165415","lineage4.7","se","Sweden","pnca_p.asp8asn","A","-","ASP","DA8","pnca_complex.pdb"
|
|
"D8N","L2","PZA","D","D8",8,"N",NA,"XDR","DM","hydrophilic","hydrophilic","acidic","neutral","neg","polar",3.22,-1.655,-1.182,-1.26057,-1.022,-1.29,92,95,-1.187,9,9,5,0.0259067357512953,"loop",1.63333333333333,9.48,0.0005030904125341,29.1630847029077,29.1630732435187,29.1293325978315,18.6717493808583,0,34,0,0,34,0,0,0,0,-4,0,-2,-2,0,0,0,0,-7,0,-5,-4,0,0,-4,2,-0.41919959473151,-0.305426356589147,-0.242361378143505,-0.174254049445865,-0.337696335078534,0.968421052631579,-0.977759472817133,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","146/150","D:H",3.37290329402598,0.001789077082818,1.07995768762031,3.12318096596746,4.97876379054103,550.894323519252,1.46483345924118,0.0001485295621003,3.828187099348,3.53443753556636,1331.56873199938,1.55265977742841e-05,"lineage2","dr_mutations_pyrazinamide","ASN",0,"ERR2515238","ERR2515238","lineage2.2.1","za","South Africa","pnca_p.asp8asn","A","-","ASP","DA8","pnca_complex.pdb"
|
|
"D8N","L2","PZA","D","D8",8,"N",1,"XDR","DM","hydrophilic","hydrophilic","acidic","neutral","neg","polar",3.22,-1.655,-1.182,-1.26057,-1.022,-1.29,92,95,-1.187,9,9,5,0.0259067357512953,"loop",1.63333333333333,9.48,0.0005030904125341,29.1630847029077,29.1630732435187,29.1293325978315,18.6717493808583,0,34,0,0,34,0,0,0,0,-4,0,-2,-2,0,0,0,0,-7,0,-5,-4,0,0,-4,2,-0.41919959473151,-0.305426356589147,-0.242361378143505,-0.174254049445865,-0.337696335078534,0.968421052631579,-0.977759472817133,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","146/150","D:H",3.37290329402598,0.001789077082818,1.07995768762031,3.12318096596746,4.97876379054103,550.894323519252,1.46483345924118,0.0001485295621003,3.828187099348,3.53443753556636,1331.56873199938,1.55265977742841e-05,"lineage2","dr_mutations_pyrazinamide","ASN",0,"ERR1873532","ERR1873532","lineage2.2.1","za","South Africa","pnca_p.asp8asn","A","-","ASP","DA8","pnca_complex.pdb"
|
|
"D8N","L2","PZA","D","D8",8,"N",1,"XDR","DM","hydrophilic","hydrophilic","acidic","neutral","neg","polar",3.22,-1.655,-1.182,-1.26057,-1.022,-1.29,92,95,-1.187,9,9,5,0.0259067357512953,"loop",1.63333333333333,9.48,0.0005030904125341,29.1630847029077,29.1630732435187,29.1293325978315,18.6717493808583,0,34,0,0,34,0,0,0,0,-4,0,-2,-2,0,0,0,0,-7,0,-5,-4,0,0,-4,2,-0.41919959473151,-0.305426356589147,-0.242361378143505,-0.174254049445865,-0.337696335078534,0.968421052631579,-0.977759472817133,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","146/150","D:H",3.37290329402598,0.001789077082818,1.07995768762031,3.12318096596746,4.97876379054103,550.894323519252,1.46483345924118,0.0001485295621003,3.828187099348,3.53443753556636,1331.56873199938,1.55265977742841e-05,"lineage2","dr_mutations_pyrazinamide","ASN",0,"ERR2515301","ERR2515301","lineage2.2.1","za","South Africa","pnca_p.asp8asn","A","-","ASP","DA8","pnca_complex.pdb"
|
|
"D8N","L2","PZA","D","D8",8,"N",NA,"Pre-XDR","DM","hydrophilic","hydrophilic","acidic","neutral","neg","polar",3.22,-1.655,-1.182,-1.26057,-1.022,-1.29,92,95,-1.187,9,9,5,0.0259067357512953,"loop",1.63333333333333,9.48,0.0005030904125341,29.1630847029077,29.1630732435187,29.1293325978315,18.6717493808583,0,34,0,0,34,0,0,0,0,-4,0,-2,-2,0,0,0,0,-7,0,-5,-4,0,0,-4,2,-0.41919959473151,-0.305426356589147,-0.242361378143505,-0.174254049445865,-0.337696335078534,0.968421052631579,-0.977759472817133,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","146/150","D:H",3.37290329402598,0.001789077082818,1.07995768762031,3.12318096596746,4.97876379054103,550.894323519252,1.46483345924118,0.0001485295621003,3.828187099348,3.53443753556636,1331.56873199938,1.55265977742841e-05,"lineage2","dr_mutations_pyrazinamide","ASN",0,"ERR2515250","ERR2515250","lineage2.2.1","za","South Africa","pnca_p.asp8asn","A","-","ASP","DA8","pnca_complex.pdb"
|
|
"V9A","L2","PZA","V","V9",9,"A",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",6.555,-1.286,-2.467,2.03689,-2.068,-2.01,61,80,-0.711,8,8,0,0,"loop",-0.933333333333333,9.57,0.0002156101768003,0.807902480033628,4.59660271789382e-05,0,0.000393645565148,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,2,0,0,2,6,0,6,5,-0.325734549138804,-0.637467700258398,0.0741879675696938,-0.352600170502984,-0.526178010471204,0.642105263157895,-0.585667215815486,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.827,-0.615,"8:7","146/150","I:C:L:V:M",-9.98760797391819,0.930014323968985,113.719344729607,-0.0878268160765962,NA,127.948735098955,-0.0926410587047397,1,0,0,11.7369754738005,0.984170607395186,"lineage2","dr_mutations_pyrazinamide","ALA",0,"SRS797047","SRR1723549","lineage2.2.1","cn","China:Hebei","pnca_p.val9ala","A","-","VAL","VA9","pnca_complex.pdb"
|
|
"V9A","L4","PZA","V","V9",9,"A",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",6.555,-1.286,-2.467,2.03689,-2.068,-2.01,61,80,-0.711,8,8,0,0,"loop",-0.933333333333333,9.57,0.0002156101768003,0.807902480033628,4.59660271789382e-05,0,0.000393645565148,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,2,0,0,2,6,0,6,5,-0.325734549138804,-0.637467700258398,0.0741879675696938,-0.352600170502984,-0.526178010471204,0.642105263157895,-0.585667215815486,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.827,-0.615,"8:7","146/150","I:C:L:V:M",-9.98760797391819,0.930014323968985,113.719344729607,-0.0878268160765962,NA,127.948735098955,-0.0926410587047397,1,0,0,11.7369754738005,0.984170607395186,"lineage4","dr_mutations_pyrazinamide","ALA",0,"SRR671850,BGI_XZ06055","SRR671850","lineage4.5","cn","China","pnca_p.val9ala","A","-","VAL","VA9","pnca_complex.pdb"
|
|
"V9A","L2","PZA","V","V9",9,"A",0,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",6.555,-1.286,-2.467,2.03689,-2.068,-2.01,61,80,-0.711,8,8,0,0,"loop",-0.933333333333333,9.57,0.0002156101768003,0.807902480033628,4.59660271789382e-05,0,0.000393645565148,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,2,0,0,2,6,0,6,5,-0.325734549138804,-0.637467700258398,0.0741879675696938,-0.352600170502984,-0.526178010471204,0.642105263157895,-0.585667215815486,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.827,-0.615,"8:7","146/150","I:C:L:V:M",-9.98760797391819,0.930014323968985,113.719344729607,-0.0878268160765962,NA,127.948735098955,-0.0926410587047397,1,0,0,11.7369754738005,0.984170607395186,"lineage2","dr_mutations_pyrazinamide","ALA",0,"SAMN10961402","SRR8651641","lineage2.2.2","cn","China:Wenzhou","pnca_p.val9ala","A","-","VAL","VA9","pnca_complex.pdb"
|
|
"V9A","L2","PZA","V","V9",9,"A",0,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",6.555,-1.286,-2.467,2.03689,-2.068,-2.01,61,80,-0.711,8,8,0,0,"loop",-0.933333333333333,9.57,0.0002156101768003,0.807902480033628,4.59660271789382e-05,0,0.000393645565148,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,2,0,0,2,6,0,6,5,-0.325734549138804,-0.637467700258398,0.0741879675696938,-0.352600170502984,-0.526178010471204,0.642105263157895,-0.585667215815486,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.827,-0.615,"8:7","146/150","I:C:L:V:M",-9.98760797391819,0.930014323968985,113.719344729607,-0.0878268160765962,NA,127.948735098955,-0.0926410587047397,1,0,0,11.7369754738005,0.984170607395186,"lineage2","dr_mutations_pyrazinamide","ALA",0,"SAMN10961331","SRR8651653","lineage2.2.2","cn","China:Wenzhou","pnca_p.val9ala","A","-","VAL","VA9","pnca_complex.pdb"
|
|
"V9A","L2","PZA","V","V9",9,"A",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",6.555,-1.286,-2.467,2.03689,-2.068,-2.01,61,80,-0.711,8,8,0,0,"loop",-0.933333333333333,9.57,0.0002156101768003,0.807902480033628,4.59660271789382e-05,0,0.000393645565148,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,2,0,0,2,6,0,6,5,-0.325734549138804,-0.637467700258398,0.0741879675696938,-0.352600170502984,-0.526178010471204,0.642105263157895,-0.585667215815486,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.827,-0.615,"8:7","146/150","I:C:L:V:M",-9.98760797391819,0.930014323968985,113.719344729607,-0.0878268160765962,NA,127.948735098955,-0.0926410587047397,1,0,0,11.7369754738005,0.984170607395186,"lineage2","dr_mutations_pyrazinamide","ALA",0,"SRR8380932","SRR8380932","lineage2.2.1","in","India","pnca_p.val9ala","A","-","VAL","VA9","pnca_complex.pdb"
|
|
"V9A","L2;L4","PZA","V","V9",9,"A",0,"MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",6.555,-1.286,-2.467,2.03689,-2.068,-2.01,61,80,-0.711,8,8,0,0,"loop",-0.933333333333333,9.57,0.0002156101768003,0.807902480033628,4.59660271789382e-05,0,0.000393645565148,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,2,0,0,2,6,0,6,5,-0.325734549138804,-0.637467700258398,0.0741879675696938,-0.352600170502984,-0.526178010471204,0.642105263157895,-0.585667215815486,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.827,-0.615,"8:7","146/150","I:C:L:V:M",-9.98760797391819,0.930014323968985,113.719344729607,-0.0878268160765962,NA,127.948735098955,-0.0926410587047397,1,0,0,11.7369754738005,0.984170607395186,"lineage2;lineage4","dr_mutations_pyrazinamide","ALA",0,"MDR_3208","SRR6824304","lineage4;lineage2.2.1","cn","China: Jize County, Handan City, Hebei Province","pnca_p.val9ala","A","-","VAL","VA9","pnca_complex.pdb"
|
|
"V9A","L2","PZA","V","V9",9,"A",NA,"XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",6.555,-1.286,-2.467,2.03689,-2.068,-2.01,61,80,-0.711,8,8,0,0,"loop",-0.933333333333333,9.57,0.0002156101768003,0.807902480033628,4.59660271789382e-05,0,0.000393645565148,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,2,0,0,2,6,0,6,5,-0.325734549138804,-0.637467700258398,0.0741879675696938,-0.352600170502984,-0.526178010471204,0.642105263157895,-0.585667215815486,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.827,-0.615,"8:7","146/150","I:C:L:V:M",-9.98760797391819,0.930014323968985,113.719344729607,-0.0878268160765962,NA,127.948735098955,-0.0926410587047397,1,0,0,11.7369754738005,0.984170607395186,"lineage2","dr_mutations_pyrazinamide","ALA",0,"SRS935963,SAMN03653228","SRR2024922","lineage2.2.1","cn","China","pnca_p.val9ala","A","-","VAL","VA9","pnca_complex.pdb"
|
|
"V9G","L3","PZA","V","V9",9,"G",1,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",6.555,-1.063,-3.236,3.70952,-3.636,-3.48,83,91,-0.711,8,8,0,0,"loop",-0.933333333333333,9.57,0.0003593502946672,19.4256842105263,19.4256680571767,19.4169790983636,9.87561363723508,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,2,-2,4,0,3,21,-0.269250253292806,-0.836175710594315,0.135108793041907,-0.619948849104859,-0.910994764397906,0.873684210526316,-0.585667215815486,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.827,-0.615,"8:7","146/150","I:C:L:V:M",2.96659528728018,0.0079500503166053,1.11770528264822,2.65418382943607,2.87215213651501,380.097158975938,1.28837632444196,0.0036816889015929,2.43395291165754,1.92061868691892,951.403114304703,0.0016748373055023,"lineage3","dr_mutations_pyrazinamide","GLY",0,"ERR2510586","ERR2510586","lineage3","pk","Pakistan","pnca_p.val9gly","A","-","VAL","VA9","pnca_complex.pdb"
|
|
"V9G","L3","PZA","V","V9",9,"G",1,"Pre-MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",6.555,-1.063,-3.236,3.70952,-3.636,-3.48,83,91,-0.711,8,8,0,0,"loop",-0.933333333333333,9.57,0.0003593502946672,19.4256842105263,19.4256680571767,19.4169790983636,9.87561363723508,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,2,-2,4,0,3,21,-0.269250253292806,-0.836175710594315,0.135108793041907,-0.619948849104859,-0.910994764397906,0.873684210526316,-0.585667215815486,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.827,-0.615,"8:7","146/150","I:C:L:V:M",2.96659528728018,0.0079500503166053,1.11770528264822,2.65418382943607,2.87215213651501,380.097158975938,1.28837632444196,0.0036816889015929,2.43395291165754,1.92061868691892,951.403114304703,0.0016748373055023,"lineage3","dr_mutations_pyrazinamide","GLY",0,"ERR2515261","ERR2515261","lineage3","za","South Africa","pnca_p.val9gly","A","-","VAL","VA9","pnca_complex.pdb"
|
|
"V9G","L3","PZA","V","V9",9,"G",0,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",6.555,-1.063,-3.236,3.70952,-3.636,-3.48,83,91,-0.711,8,8,0,0,"loop",-0.933333333333333,9.57,0.0003593502946672,19.4256842105263,19.4256680571767,19.4169790983636,9.87561363723508,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,2,-2,4,0,3,21,-0.269250253292806,-0.836175710594315,0.135108793041907,-0.619948849104859,-0.910994764397906,0.873684210526316,-0.585667215815486,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.827,-0.615,"8:7","146/150","I:C:L:V:M",2.96659528728018,0.0079500503166053,1.11770528264822,2.65418382943607,2.87215213651501,380.097158975938,1.28837632444196,0.0036816889015929,2.43395291165754,1.92061868691892,951.403114304703,0.0016748373055023,"lineage3","dr_mutations_pyrazinamide","GLY",0,"ERR2510469","ERR2510469","lineage3","pk","Pakistan","pnca_p.val9gly","A","-","VAL","VA9","pnca_complex.pdb"
|
|
"V9G","L4","PZA","V","V9",9,"G",1,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",6.555,-1.063,-3.236,3.70952,-3.636,-3.48,83,91,-0.711,8,8,0,0,"loop",-0.933333333333333,9.57,0.0003593502946672,19.4256842105263,19.4256680571767,19.4169790983636,9.87561363723508,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,2,-2,4,0,3,21,-0.269250253292806,-0.836175710594315,0.135108793041907,-0.619948849104859,-0.910994764397906,0.873684210526316,-0.585667215815486,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.827,-0.615,"8:7","146/150","I:C:L:V:M",2.96659528728018,0.0079500503166053,1.11770528264822,2.65418382943607,2.87215213651501,380.097158975938,1.28837632444196,0.0036816889015929,2.43395291165754,1.92061868691892,951.403114304703,0.0016748373055023,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR2516547","ERR2516547","lineage4.1.1","pe","Peru","pnca_p.val9gly","A","-","VAL","VA9","pnca_complex.pdb"
|
|
"V9G","L3","PZA","V","V9",9,"G",1,"Pre-MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",6.555,-1.063,-3.236,3.70952,-3.636,-3.48,83,91,-0.711,8,8,0,0,"loop",-0.933333333333333,9.57,0.0003593502946672,19.4256842105263,19.4256680571767,19.4169790983636,9.87561363723508,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,2,-2,4,0,3,21,-0.269250253292806,-0.836175710594315,0.135108793041907,-0.619948849104859,-0.910994764397906,0.873684210526316,-0.585667215815486,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.827,-0.615,"8:7","146/150","I:C:L:V:M",2.96659528728018,0.0079500503166053,1.11770528264822,2.65418382943607,2.87215213651501,380.097158975938,1.28837632444196,0.0036816889015929,2.43395291165754,1.92061868691892,951.403114304703,0.0016748373055023,"lineage3","dr_mutations_pyrazinamide","GLY",0,"ERR2516050","ERR2516050","lineage3","za","South Africa","pnca_p.val9gly","A","-","VAL","VA9","pnca_complex.pdb"
|
|
"Q10E","L2","PZA","Q","Q10",10,"E",NA,"XDR","OM","hydrophilic","hydrophilic","neutral","acidic","polar","neg",6.02,-0.537,-2.051,3.84692,-1.976,-0.13,88,91,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,NA,NA,NA,NA,NA,0,-56,0,0,-56,0,0,0,0,0,0,2,-2,0,0,0,0,-4,0,-6,1,0,0,0,4,-0.136018237082067,-0.529974160206718,0.140113200125292,-0.33691389599318,-0.0340314136125654,0.926315789473684,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage2","other_mutations_pyrazinamide","GLU",0,"DRR184878","DRR184878","lineage2.2.1","vn","Vietnam","pnca_p.gln10glu","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10E","L2","PZA","Q","Q10",10,"E",NA,"MDR","OM","hydrophilic","hydrophilic","neutral","acidic","polar","neg",6.02,-0.537,-2.051,3.84692,-1.976,-0.13,88,91,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,NA,NA,NA,NA,NA,0,-56,0,0,-56,0,0,0,0,0,0,2,-2,0,0,0,0,-4,0,-6,1,0,0,0,4,-0.136018237082067,-0.529974160206718,0.140113200125292,-0.33691389599318,-0.0340314136125654,0.926315789473684,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage2","other_mutations_pyrazinamide","GLU",0,"DRR184942","DRR184942","lineage2.2.1","vn","Vietnam","pnca_p.gln10glu","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10H","L4","PZA","Q","Q10",10,"H",1,"MDR","DM","hydrophilic","hydrophobic","neutral","basic","polar","pos",6.02,-0.636,-1.024,3.94633,-1.814,-0.97,91,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0007905706482679,107.166385135135,3795803.48336072,Inf,47.6847963834956,4,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,-11,0,-8,-3,0,0,2,2,-0.161094224924012,-0.264599483204134,0.143733928714516,-0.309292412617221,-0.253926701570681,0.957894736842105,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",15.1494066679727,0.925233417916174,161.432542878774,0.0938435732834176,24.1993753469043,NA,2.03005858162844,3.58120158191569e-09,8.44597123233921,12.2081619622864,Inf,5.00558510128865e-12,"lineage4","dr_mutations_pyrazinamide","HIS",0,"436","ERR3014581","lineage4.1.2.1","tn","Tunisia:Bizerte","pnca_p.gln10his","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10H","L4","PZA","Q","Q10",10,"H",1,"MDR","DM","hydrophilic","hydrophobic","neutral","basic","polar","pos",6.02,-0.636,-1.024,3.94633,-1.814,-0.97,91,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0007905706482679,107.166385135135,3795803.48336072,Inf,47.6847963834956,4,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,-11,0,-8,-3,0,0,2,2,-0.161094224924012,-0.264599483204134,0.143733928714516,-0.309292412617221,-0.253926701570681,0.957894736842105,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",15.1494066679727,0.925233417916174,161.432542878774,0.0938435732834176,24.1993753469043,NA,2.03005858162844,3.58120158191569e-09,8.44597123233921,12.2081619622864,Inf,5.00558510128865e-12,"lineage4","dr_mutations_pyrazinamide","HIS",0,"3553","ERR3013479","lineage4.1.2.1","tn","Tunisia:Bizerte","pnca_p.gln10his","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10H","L4","PZA","Q","Q10",10,"H",1,"XDR","DM","hydrophilic","hydrophobic","neutral","basic","polar","pos",6.02,-0.636,-1.024,3.94633,-1.814,-0.97,91,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0007905706482679,107.166385135135,3795803.48336072,Inf,47.6847963834956,4,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,-11,0,-8,-3,0,0,2,2,-0.161094224924012,-0.264599483204134,0.143733928714516,-0.309292412617221,-0.253926701570681,0.957894736842105,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",15.1494066679727,0.925233417916174,161.432542878774,0.0938435732834176,24.1993753469043,NA,2.03005858162844,3.58120158191569e-09,8.44597123233921,12.2081619622864,Inf,5.00558510128865e-12,"lineage4","dr_mutations_pyrazinamide","HIS",0,"8626","ERR3014594","lineage4.1.2.1","tn","Tunisia:Bizerte","pnca_p.gln10his","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10H","L4","PZA","Q","Q10",10,"H",1,"MDR","DM","hydrophilic","hydrophobic","neutral","basic","polar","pos",6.02,-0.636,-1.024,3.94633,-1.814,-0.97,91,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0007905706482679,107.166385135135,3795803.48336072,Inf,47.6847963834956,4,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,-11,0,-8,-3,0,0,2,2,-0.161094224924012,-0.264599483204134,0.143733928714516,-0.309292412617221,-0.253926701570681,0.957894736842105,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",15.1494066679727,0.925233417916174,161.432542878774,0.0938435732834176,24.1993753469043,NA,2.03005858162844,3.58120158191569e-09,8.44597123233921,12.2081619622864,Inf,5.00558510128865e-12,"lineage4","dr_mutations_pyrazinamide","HIS",0,"8649","ERR3014595","lineage4.1.2.1","tn","Tunisia:Bizerte","pnca_p.gln10his","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10H","L4","PZA","Q","Q10",10,"H",1,"MDR","DM","hydrophilic","hydrophobic","neutral","basic","polar","pos",6.02,-0.636,-1.024,3.94633,-1.814,-0.97,91,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0007905706482679,107.166385135135,3795803.48336072,Inf,47.6847963834956,4,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,-11,0,-8,-3,0,0,2,2,-0.161094224924012,-0.264599483204134,0.143733928714516,-0.309292412617221,-0.253926701570681,0.957894736842105,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",15.1494066679727,0.925233417916174,161.432542878774,0.0938435732834176,24.1993753469043,NA,2.03005858162844,3.58120158191569e-09,8.44597123233921,12.2081619622864,Inf,5.00558510128865e-12,"lineage4","dr_mutations_pyrazinamide","HIS",0,"13025","ERR3014604","lineage4.1.2.1","tn","Tunisia:Bizerte","pnca_p.gln10his","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10H","L4","PZA","Q","Q10",10,"H",1,"Pre-XDR","DM","hydrophilic","hydrophobic","neutral","basic","polar","pos",6.02,-0.636,-1.024,3.94633,-1.814,-0.97,91,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0007905706482679,107.166385135135,3795803.48336072,Inf,47.6847963834956,4,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,-11,0,-8,-3,0,0,2,2,-0.161094224924012,-0.264599483204134,0.143733928714516,-0.309292412617221,-0.253926701570681,0.957894736842105,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",15.1494066679727,0.925233417916174,161.432542878774,0.0938435732834176,24.1993753469043,NA,2.03005858162844,3.58120158191569e-09,8.44597123233921,12.2081619622864,Inf,5.00558510128865e-12,"lineage4","dr_mutations_pyrazinamide","HIS",0,"10942","ERR3014599","lineage4.1.2.1","tn","Tunisia:Bizerte","pnca_p.gln10his","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10H","L2","PZA","Q","Q10",10,"H",1,"Pre-XDR","DM","hydrophilic","hydrophobic","neutral","basic","polar","pos",6.02,-0.636,-1.024,3.94633,-1.814,-0.97,91,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0007905706482679,107.166385135135,3795803.48336072,Inf,47.6847963834956,4,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,-11,0,-8,-3,0,0,2,2,-0.161094224924012,-0.264599483204134,0.143733928714516,-0.309292412617221,-0.253926701570681,0.957894736842105,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",15.1494066679727,0.925233417916174,161.432542878774,0.0938435732834176,24.1993753469043,NA,2.03005858162844,3.58120158191569e-09,8.44597123233921,12.2081619622864,Inf,5.00558510128865e-12,"lineage2","dr_mutations_pyrazinamide","HIS",0,"MDR_19329","SRR6824407","lineage2.2.1","cn","China: Luoding City, Yunfu City, Guangdong Province","pnca_p.gln10his","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10H","L2","PZA","Q","Q10",10,"H",1,"XDR","DM","hydrophilic","hydrophobic","neutral","basic","polar","pos",6.02,-0.636,-1.024,3.94633,-1.814,-0.97,91,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0007905706482679,107.166385135135,3795803.48336072,Inf,47.6847963834956,4,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,-11,0,-8,-3,0,0,2,2,-0.161094224924012,-0.264599483204134,0.143733928714516,-0.309292412617221,-0.253926701570681,0.957894736842105,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",15.1494066679727,0.925233417916174,161.432542878774,0.0938435732834176,24.1993753469043,NA,2.03005858162844,3.58120158191569e-09,8.44597123233921,12.2081619622864,Inf,5.00558510128865e-12,"lineage2","dr_mutations_pyrazinamide","HIS",0,"ERR2516546","ERR2516546","lineage2.2.1","pe","Peru","pnca_p.gln10his","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10H","L4","PZA","Q","Q10",10,"H",1,"MDR","DM","hydrophilic","hydrophobic","neutral","basic","polar","pos",6.02,-0.636,-1.024,3.94633,-1.814,-0.97,91,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0007905706482679,107.166385135135,3795803.48336072,Inf,47.6847963834956,4,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,-11,0,-8,-3,0,0,2,2,-0.161094224924012,-0.264599483204134,0.143733928714516,-0.309292412617221,-0.253926701570681,0.957894736842105,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",15.1494066679727,0.925233417916174,161.432542878774,0.0938435732834176,24.1993753469043,NA,2.03005858162844,3.58120158191569e-09,8.44597123233921,12.2081619622864,Inf,5.00558510128865e-12,"lineage4","dr_mutations_pyrazinamide","HIS",0,"2109","ERR3014583","lineage4.1.2.1","tn","Tunisia:Bizerte","pnca_p.gln10his","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10H","L4","PZA","Q","Q10",10,"H",1,"XDR","DM","hydrophilic","hydrophobic","neutral","basic","polar","pos",6.02,-0.636,-1.024,3.94633,-1.814,-0.97,91,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0007905706482679,107.166385135135,3795803.48336072,Inf,47.6847963834956,4,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,-11,0,-8,-3,0,0,2,2,-0.161094224924012,-0.264599483204134,0.143733928714516,-0.309292412617221,-0.253926701570681,0.957894736842105,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",15.1494066679727,0.925233417916174,161.432542878774,0.0938435732834176,24.1993753469043,NA,2.03005858162844,3.58120158191569e-09,8.44597123233921,12.2081619622864,Inf,5.00558510128865e-12,"lineage4","dr_mutations_pyrazinamide","HIS",0,"14666","ERR3014613","lineage4.1.2.1","tn","Tunisia:Bizerte","pnca_p.gln10his","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10H","L4","PZA","Q","Q10",10,"H",1,"MDR","DM","hydrophilic","hydrophobic","neutral","basic","polar","pos",6.02,-0.636,-1.024,3.94633,-1.814,-0.97,91,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0007905706482679,107.166385135135,3795803.48336072,Inf,47.6847963834956,4,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,-11,0,-8,-3,0,0,2,2,-0.161094224924012,-0.264599483204134,0.143733928714516,-0.309292412617221,-0.253926701570681,0.957894736842105,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",15.1494066679727,0.925233417916174,161.432542878774,0.0938435732834176,24.1993753469043,NA,2.03005858162844,3.58120158191569e-09,8.44597123233921,12.2081619622864,Inf,5.00558510128865e-12,"lineage4","dr_mutations_pyrazinamide","HIS",0,"5069","ERR3014587","lineage4.1.2.1","tn","Tunisia:Bizerte","pnca_p.gln10his","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10H","L2","PZA","Q","Q10",10,"H",NA,"Pre-XDR","DM","hydrophilic","hydrophobic","neutral","basic","polar","pos",6.02,-0.636,-1.024,3.94633,-1.814,-0.97,91,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0007905706482679,107.166385135135,3795803.48336072,Inf,47.6847963834956,4,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,-11,0,-8,-3,0,0,2,2,-0.161094224924012,-0.264599483204134,0.143733928714516,-0.309292412617221,-0.253926701570681,0.957894736842105,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",15.1494066679727,0.925233417916174,161.432542878774,0.0938435732834176,24.1993753469043,NA,2.03005858162844,3.58120158191569e-09,8.44597123233921,12.2081619622864,Inf,5.00558510128865e-12,"lineage2","dr_mutations_pyrazinamide","HIS",0,"SRS797051","SRR1723552","lineage2.2.1","cn","China:Guangdong","pnca_p.gln10his","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10L","L4","PZA","Q","Q10",10,"L",NA,"Pre-XDR","OM","hydrophilic","hydrophobic","neutral","non-polar","polar","non-polar",6.02,-1.694,0.641,0.169275,-0.188,0.05,91,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,NA,NA,NA,NA,NA,20,0,0,0,0,0,0,0,0,4,0,4,0,0,0,0,0,-3,0,-3,-3,2,0,6,4,-0.429078014184397,0.545068027210884,0.00616536396681211,-0.0320545609548167,0.0280898876404494,0.957894736842105,-1,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.229,-1.201,"9:9","147/150","Q",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage4","other_mutations_pyrazinamide","LEU",0,"SAMN02567710","SRR1166324","lineage4.1.2.1","ro","Romania","pnca_p.gln10leu","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760750","ERR760750","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760884","ERR760884","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR757161","ERR757161","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760867","ERR760867","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L2","PZA","Q","Q10",10,"P",NA,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage2","dr_mutations_pyrazinamide","PRO",0,"SAMN02360601","SRR1049039_SRR1013645_SRR1013644_SRR1049038","lineage2.2.2","kr","South Korea","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR757145","ERR757145","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERS457454","ERR551592_ERR551591","lineage4.8","uz","Nukus","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760838","ERR760838","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760823","ERR760823","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760881","ERR760881","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L1","PZA","Q","Q10",10,"P",NA,"MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage1","dr_mutations_pyrazinamide","PRO",0,"SRR8380876","SRR8380876","lineage1.1.2","in","India","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR757162","ERR757162","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760738","ERR760738","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760822","ERR760822","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760795","ERR760795","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760799","ERR760799","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L2","PZA","Q","Q10",10,"P",1,"MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage2","dr_mutations_pyrazinamide","PRO",0,"SAMEA2534067,ERS457469","ERR551610_ERR551611","lineage2.2.1","uz","Nukus","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760736","ERR760736","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR757188","ERR757188","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760902","ERR760902","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760916","ERR760916","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",NA,"MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR1023472","ERR1023472","lineage4.3.2.1","","","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L2","PZA","Q","Q10",10,"P",1,"MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage2","dr_mutations_pyrazinamide","PRO",0,"ERS458053,SAMEA2534651,ERR552441","ERR552441","lineage2.2.1","uz","Nukus","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760846","ERR760846","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L2","PZA","Q","Q10",10,"P",1,"MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage2","dr_mutations_pyrazinamide","PRO",0,"ERS457589,SAMEA2534187","ERR551780_ERR551781","lineage2.2.1","uz","Nukus","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR757178","ERR757178","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760739","ERR760739","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L2","PZA","Q","Q10",10,"P",1,"MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage2","dr_mutations_pyrazinamide","PRO",0,"ERS457017,SAMEA2533615","ERR550988_ERR550989_ERR550990","lineage2.2.1","uz","Nukus","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760836","ERR760836","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",NA,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR1035005","ERR1035005","lineage4.4.1.1","za","South Africa","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L2","PZA","Q","Q10",10,"P",1,"MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage2","dr_mutations_pyrazinamide","PRO",0,"ERS458603","ERR553189_ERR553188_ERR553190","lineage2.2.1","uz","Nukus","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L2","PZA","Q","Q10",10,"P",1,"MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage2","dr_mutations_pyrazinamide","PRO",0,"ERS457844","ERR552144_ERR552143_ERR552142","lineage2.2.1","uz","Nukus","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760896","ERR760896","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L2","PZA","Q","Q10",10,"P",NA,"Pre-MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage2","dr_mutations_pyrazinamide","PRO",0,"0932P-sc-2011-09-07T13:19:25Z-1276485,ERR067638","ERR067638","lineage2.2.1","ru","Russia","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760764","ERR760764","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L2","PZA","Q","Q10",10,"P",NA,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage2","dr_mutations_pyrazinamide","PRO",0,"SRS797090","SRR1723595_SRR1723596","lineage2.2.1","cn","China:Jiangxi","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L2","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage2","dr_mutations_pyrazinamide","PRO",0,"ERS457881","ERR552198_ERR552199_ERR552197_ERR552200","lineage2.2.1","uz","Nukus","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR757175","ERR757175","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760864","ERR760864","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L2","PZA","Q","Q10",10,"P",0,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage2","dr_mutations_pyrazinamide","PRO",0,"ERS458645","ERR553247_ERR553246","lineage2.2.1","uz","Nukus","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760747","ERR760747","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L2","PZA","Q","Q10",10,"P",0,"MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage2","dr_mutations_pyrazinamide","PRO",0,"ERS458206","ERR552661_ERR552660","lineage2.2.1","uz","Nukus","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR757183","ERR757183","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760831","ERR760831","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L2","PZA","Q","Q10",10,"P",NA,"MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage2","dr_mutations_pyrazinamide","PRO",0,"BGI_SH068,SRR671811","SRR671811","lineage2.2.1","cn","China","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L2","PZA","Q","Q10",10,"P",1,"MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage2","dr_mutations_pyrazinamide","PRO",0,"ERS457920,SAMEA2534518","ERR552257_ERR552258","lineage2.2.1","uz","Nukus","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR757167","ERR757167","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760909","ERR760909","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L2","PZA","Q","Q10",10,"P",1,"MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage2","dr_mutations_pyrazinamide","PRO",0,"ERS458105,SAMEA2534703","ERR552519_ERR552520","lineage2.2.1","uz","Nukus","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L2","PZA","Q","Q10",10,"P",1,"MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage2","dr_mutations_pyrazinamide","PRO",0,"ERS456825","ERR550725_ERR550724","lineage2.2.1","uz","Nukus","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR757181","ERR757181","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L2","PZA","Q","Q10",10,"P",1,"MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage2","dr_mutations_pyrazinamide","PRO",0,"ERS457558,SAMEA2534156","ERR551735_ERR551736","lineage2.2.1","uz","Nukus","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L2","PZA","Q","Q10",10,"P",NA,"MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage2","dr_mutations_pyrazinamide","PRO",0,"SAMEA2533983,ERS457385","ERR551495_ERR551496","lineage2.2.1","uz","Nukus","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760853","ERR760853","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L3;L4","PZA","Q","Q10",10,"P",1,"MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage3;lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760733","ERR760733","lineage4.1.2.1;lineage3","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760906","ERR760906","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760790","ERR760790","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L2","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage2","dr_mutations_pyrazinamide","PRO",0,"ERS457132","ERR551142_ERR551141","lineage2.2.1","uz","Nukus","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR757148","ERR757148","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760890","ERR760890","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",NA,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR1035032","ERR1035032","lineage4.4.1.1","za","South Africa","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760818","ERR760818","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760869","ERR760869","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760791","ERR760791","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760789","ERR760789","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L2","PZA","Q","Q10",10,"P",1,"MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage2","dr_mutations_pyrazinamide","PRO",0,"ERR552194","ERR552194","lineage2.2.1","az","Azerbaijan","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR757177","ERR757177","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760778","ERR760778","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760596","ERR760596","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760757","ERR760757","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR762353","ERR762353","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760763","ERR760763","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR757174","ERR757174","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L2","PZA","Q","Q10",10,"P",1,"MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage2","dr_mutations_pyrazinamide","PRO",0,"ERS458165","ERR552607_ERR552606","lineage2.2.1","uz","Nukus","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760885","ERR760885","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760595","ERR760595","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760731","ERR760731","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760599","ERR760599","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR757163","ERR757163","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L3","PZA","Q","Q10",10,"P",1,"MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage3","dr_mutations_pyrazinamide","PRO",0,"ERR2516596","ERR2516596","lineage3","nl","Netherlands","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR757159","ERR757159","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L2","PZA","Q","Q10",10,"P",1,"MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage2","dr_mutations_pyrazinamide","PRO",0,"ERS457898","ERR552226_ERR552225","lineage2.2.1","uz","Nukus","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L2","PZA","Q","Q10",10,"P",1,"MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage2","dr_mutations_pyrazinamide","PRO",0,"ERS456842","ERR550744_ERR550743","lineage2.2.1","uz","Nukus","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",NA,"MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"SAMN02584622","SRR1168978_SRR1166201","lineage4.2.1","md","Moldova","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR757152","ERR757152","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L2","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage2","dr_mutations_pyrazinamide","PRO",0,"ERS458379","ERR552883_ERR552882","lineage2.2.1","uz","Nukus","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760882","ERR760882","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760857","ERR760857","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760924","ERR760924","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760863","ERR760863","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L2","PZA","Q","Q10",10,"P",1,"MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage2","dr_mutations_pyrazinamide","PRO",0,"ERS458605,SAMEA2535203","ERR553194_ERR553195","lineage2.2.1","uz","Nukus","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760837","ERR760837","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760758","ERR760758","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760862","ERR760862","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L2","PZA","Q","Q10",10,"P",1,"MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage2","dr_mutations_pyrazinamide","PRO",0,"ERS457024","ERR551000_ERR550999","lineage2.2.1","uz","Nukus","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760787","ERR760787","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760601","ERR760601","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760761","ERR760761","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760865","ERR760865","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L2","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage2","dr_mutations_pyrazinamide","PRO",0,"ERS457156","ERR551172_ERR551173_ERR551171","lineage2.2.1","uz","Nukus","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760927","ERR760927","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760841","ERR760841","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760872","ERR760872","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760905","ERR760905","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760811","ERR760811","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L2","PZA","Q","Q10",10,"P",NA,"MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage2","dr_mutations_pyrazinamide","PRO",0,"DRR184887","DRR184887","lineage2.2.2","vn","Vietnam","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760803","ERR760803","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR757185","ERR757185","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR845327","ERR845327","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760611","ERR760611","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760859","ERR760859","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",NA,"MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR779905","ERR779905","lineage4.1.2.1","pe","","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR845329","ERR845329","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760751","ERR760751","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L2","PZA","Q","Q10",10,"P",0,"MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage2","dr_mutations_pyrazinamide","PRO",0,"ERS457587","ERR551776_ERR551777_ERR551775","lineage2.2.1","uz","Nukus","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L2","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage2","dr_mutations_pyrazinamide","PRO",0,"SAMEA2534702,ERR552517,ERS458104","ERR552517","lineage2.2.1","uz","Nukus","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760908","ERR760908","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR845303","ERR845303","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760876","ERR760876","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L1","PZA","Q","Q10",10,"P",NA,"Pre-MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage1","dr_mutations_pyrazinamide","PRO",0,"ERR752114","ERR752114","lineage1.1.1","th","Thailand","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L2","PZA","Q","Q10",10,"P",0,"MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage2","dr_mutations_pyrazinamide","PRO",0,"ERS456887,SAMEA2533485","ERR550808_ERR550809","lineage2.2.1","uz","Nukus","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760903","ERR760903","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760800","ERR760800","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR845305","ERR845305","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR757179","ERR757179","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760759","ERR760759","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760875","ERR760875","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR757176","ERR757176","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760786","ERR760786","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760600","ERR760600","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760917","ERR760917","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760765","ERR760765","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L2","PZA","Q","Q10",10,"P",NA,"XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage2","dr_mutations_pyrazinamide","PRO",0,"ERR502895","ERR502895","lineage2.2.1","","","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760883","ERR760883","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR845307","ERR845307","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760766","ERR760766","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR757184","ERR757184","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L2","PZA","Q","Q10",10,"P",1,"MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage2","dr_mutations_pyrazinamide","PRO",0,"ERS457752,SAMEA2534350","ERR552011_ERR552012","lineage2.2.1","uz","Nukus","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L2","PZA","Q","Q10",10,"P",NA,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage2","dr_mutations_pyrazinamide","PRO",0,"0732X-sc-2012-02-09T18:56:52Z-1355251,ERR133918","ERR133918","lineage2.2.1","ru","Russia","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760894","ERR760894","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760756","ERR760756","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR845330","ERR845330","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760734","ERR760734","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L2","PZA","Q","Q10",10,"P",1,"MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage2","dr_mutations_pyrazinamide","PRO",0,"SAMEA2533835,ERS457237","ERR551284_ERR551285","lineage2.2.1","uz","Nukus","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760921","ERR760921","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L2","PZA","Q","Q10",10,"P",1,"MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage2","dr_mutations_pyrazinamide","PRO",0,"SAMEA2533733,ERS457135,ERR551145","ERR551145","lineage2.2.1","uz","Nukus","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760850","ERR760850","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760754","ERR760754","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR757164","ERR757164","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760737","ERR760737","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760912","ERR760912","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L5","PZA","Q","Q10",10,"P",NA,"MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage5","dr_mutations_pyrazinamide","PRO",0,"ERR1203070","ERR1203070","lineage5","gh","Ghana","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",NA,"MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR779904","ERR779904","lineage4.1.2.1;lineage4.1.1","pe","","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L2","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage2","dr_mutations_pyrazinamide","PRO",0,"ERS456835","ERR550736_ERR550735","lineage2.2.1","uz","Nukus","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR757171","ERR757171","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L2","PZA","Q","Q10",10,"P",NA,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage2","dr_mutations_pyrazinamide","PRO",0,"BGI_GZ10109,SRR671844","SRR671844","lineage2.2.1","cn","China","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760781","ERR760781","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760752","ERR760752","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760735","ERR760735","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760847","ERR760847","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760891","ERR760891","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L3","PZA","Q","Q10",10,"P",0,"MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage3","dr_mutations_pyrazinamide","PRO",0,"ERR3335773","ERR3335773","lineage3","pk","Pakistan","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760886","ERR760886","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760901","ERR760901","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR845328","ERR845328","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760918","ERR760918","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760860","ERR760860","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L2","PZA","Q","Q10",10,"P",0,"MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage2","dr_mutations_pyrazinamide","PRO",0,"ERS458141","ERR552570_ERR552571_ERR552569","lineage2.2.1","uz","Nukus","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR2510493","ERR2510493","lineage4.8","pk","Pakistan","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L2","PZA","Q","Q10",10,"P",NA,"MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage2","dr_mutations_pyrazinamide","PRO",0,"ETB0054","SRR6256989","lineage2.2.1","ru","Russia:Khabarovsk","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR845306","ERR845306","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760753","ERR760753","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760915","ERR760915","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760801","ERR760801","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L2","PZA","Q","Q10",10,"P",1,"MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage2","dr_mutations_pyrazinamide","PRO",0,"ERS2592784","ERR2677438","lineage2.2.1","de","Germany","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",NA,"MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"SAMN02584631","SRR1169016_SRR1166144","lineage4.2.1","md","Moldova","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760802","ERR760802","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR762352","ERR762352","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760848","ERR760848","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L2","PZA","Q","Q10",10,"P",NA,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage2","dr_mutations_pyrazinamide","PRO",0,"SAMN02414989","SRR1165586_SRR1162726_SRR1166938_SRR1165527","lineage2.2.1","se","Sweden","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760784","ERR760784","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L2","PZA","Q","Q10",10,"P",0,"MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage2","dr_mutations_pyrazinamide","PRO",0,"ERS458271","ERR552747_ERR552748_ERR552746","lineage2.2.1","uz","Nukus","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760866","ERR760866","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760815","ERR760815","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L2","PZA","Q","Q10",10,"P",0,"MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage2","dr_mutations_pyrazinamide","PRO",0,"SAMN02053789","SRR833133_SRR833021","lineage2.2.1","za","South Africa","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760852","ERR760852","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760855","ERR760855","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L2","PZA","Q","Q10",10,"P",NA,"MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage2","dr_mutations_pyrazinamide","PRO",0,"SAMN02053788","SRR833010_SRR833169","lineage2.2.1","za","South Africa","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760911","ERR760911","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760788","ERR760788","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760612","ERR760612","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR1873449","ERR1873449","lineage4.4.1.1","za","South Africa","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L2","PZA","Q","Q10",10,"P",0,"MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage2","dr_mutations_pyrazinamide","PRO",0,"ERS458018","ERR552390_ERR552389","lineage2.2.1","uz","Nukus","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760793","ERR760793","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760873","ERR760873","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760768","ERR760768","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR757169","ERR757169","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L2","PZA","Q","Q10",10,"P",1,"MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage2","dr_mutations_pyrazinamide","PRO",0,"14MT_6111","SRR5526917","lineage2.2.1.1","pg","","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L2","PZA","Q","Q10",10,"P",NA,"Pre-MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage2","dr_mutations_pyrazinamide","PRO",0,"ERR551155","ERR551155","lineage2.2.1.1","th","Thailand","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR1873459","ERR1873459","lineage4.4.1.1","za","South Africa","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760874","ERR760874","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760755","ERR760755","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760745","ERR760745","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760845","ERR760845","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760798","ERR760798","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760904","ERR760904","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR757150","ERR757150","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR757180","ERR757180","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L3","PZA","Q","Q10",10,"P",1,"XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage3","dr_mutations_pyrazinamide","PRO",0,"ERR2510576","ERR2510576","lineage3","pk","Pakistan","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760854","ERR760854","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760861","ERR760861","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760598","ERR760598","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR757165","ERR757165","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L2","PZA","Q","Q10",10,"P",1,"MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage2","dr_mutations_pyrazinamide","PRO",0,"ERS458764","ERR553394_ERR553393","lineage2.2.1","uz","Nukus","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760832","ERR760832","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",NA,"MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR751481","ERR751481","lineage4.1.2.1","pe","","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR757168","ERR757168","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L1","PZA","Q","Q10",10,"P",NA,"XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage1","dr_mutations_pyrazinamide","PRO",0,"SRR5710018,SAMN07236283","SRR5710018","lineage1.1.1","th","Thailand","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L2","PZA","Q","Q10",10,"P",1,"MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage2","dr_mutations_pyrazinamide","PRO",0,"13MT_2948","SRR5525982","lineage2.2.1.1","pg","","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L2","PZA","Q","Q10",10,"P",1,"MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage2","dr_mutations_pyrazinamide","PRO",0,"14MT_13360","SRR5526019","lineage2.2.1.1","pg","","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR757173","ERR757173","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L2","PZA","Q","Q10",10,"P",1,"Other","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage2","dr_mutations_pyrazinamide","PRO",0,"ERR2512746","ERR2512746","lineage2.2.1","gb","UK","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760913","ERR760913","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR2516564","ERR2516564","lineage4.4.1.1","pe","Peru","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L2","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage2","dr_mutations_pyrazinamide","PRO",0,"MDR_14257","SRR6824371","lineage2.2.1","cn","China: Jinxian County, Nanchang City, Jiangxi Province","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760851","ERR760851","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L2","PZA","Q","Q10",10,"P",1,"MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage2","dr_mutations_pyrazinamide","PRO",0,"ERS457289","ERR551362_ERR551360_ERR551361","lineage2.2.1","uz","Nukus","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",NA,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"SAMN02628509","SRR1173615_SRR1173818","lineage4.2.1","ir","Iran","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR757146","ERR757146","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760783","ERR760783","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",NA,"MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"SRR7517799","SRR7517799","lineage4.1.2.1","ch","Switzerland","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760923","ERR760923","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760858","ERR760858","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760844","ERR760844","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L2","PZA","Q","Q10",10,"P",1,"MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage2","dr_mutations_pyrazinamide","PRO",0,"SAMEA2534721,ERS458123","ERR552545_ERR552546","lineage2.2.1","uz","Nukus","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760879","ERR760879","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760817","ERR760817","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760743","ERR760743","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L2","PZA","Q","Q10",10,"P",NA,"MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage2","dr_mutations_pyrazinamide","PRO",0,"SRR5065610","SRR5065610","lineage2.2.1","vn","Vietnam","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760889","ERR760889","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760907","ERR760907","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L5","PZA","Q","Q10",10,"P",NA,"MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage5","dr_mutations_pyrazinamide","PRO",0,"ERR1215480","ERR1215480","lineage5","gh","Ghana","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760828","ERR760828","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760821","ERR760821","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760895","ERR760895","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760610","ERR760610","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760827","ERR760827","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760900","ERR760900","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L2","PZA","Q","Q10",10,"P",1,"MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage2","dr_mutations_pyrazinamide","PRO",0,"ERS457126","ERR551133_ERR551132","lineage2.2.1","uz","Nukus","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L2","PZA","Q","Q10",10,"P",1,"MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage2","dr_mutations_pyrazinamide","PRO",0,"ERS457891","ERR552216_ERR552215_ERR552217","lineage2.2.1","uz","Nukus","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760741","ERR760741","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760794","ERR760794","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760732","ERR760732","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR757151","ERR757151","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR757189","ERR757189","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760826","ERR760826","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760914","ERR760914","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760810","ERR760810","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760925","ERR760925","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760797","ERR760797","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR850262","ERR850262","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L2","PZA","Q","Q10",10,"P",1,"MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage2","dr_mutations_pyrazinamide","PRO",0,"ERR551430,SAMEA2533936,ERS457338","ERR551430","lineage2.2.1","uz","Nukus","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L2","PZA","Q","Q10",10,"P",1,"MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage2","dr_mutations_pyrazinamide","PRO",0,"ERS458388","ERR552897_ERR552896","lineage2.2.1","uz","Nukus","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",NA,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"SAMN02628479","SRR1172359_SRR1180243_SRR1183100_SRR1172171","lineage4.2.1","ir","Iran","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760825","ERR760825","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR2041788","ERR2041788","lineage4.1.2.1","rs","Serbia","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR757182","ERR757182","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760607","ERR760607","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760899","ERR760899","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760597","ERR760597","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR757172","ERR757172","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760878","ERR760878","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760602","ERR760602","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760830","ERR760830","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",NA,"MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR775358","ERR775358","lineage4.3.3","pe","","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760880","ERR760880","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760782","ERR760782","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760744","ERR760744","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR2516527","ERR2516527","lineage4.3.3","pe","Peru","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760760","ERR760760","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760813","ERR760813","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760816","ERR760816","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760833","ERR760833","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760814","ERR760814","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760835","ERR760835","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR757186","ERR757186","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760888","ERR760888","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760922","ERR760922","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760603","ERR760603","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760829","ERR760829","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR2510668","ERR2510668","lineage4.8","it","Italy","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760604","ERR760604","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760868","ERR760868","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",NA,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR1035002","ERR1035002","lineage4.4.1.1","za","South Africa","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760609","ERR760609","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760871","ERR760871","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L2","PZA","Q","Q10",10,"P",1,"MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage2","dr_mutations_pyrazinamide","PRO",0,"ERS458056,SAMEA2534654","ERR552446_ERR552447","lineage2.2.1","uz","Nukus","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760819","ERR760819","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",NA,"MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"SAMN09708345","SRR7585421","lineage4.4","in","India","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR2510552","ERR2510552","lineage4.8","pk","Pakistan","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760919","ERR760919","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760856","ERR760856","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",NA,"MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR2707013","ERR2707013","lineage4.3.4.2","cd","Democratic Republic of Congo","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR2517100","ERR2517100","lineage4.2.2","gb","UK","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR757147","ERR757147","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760779","ERR760779","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760767","ERR760767","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L2","PZA","Q","Q10",10,"P",0,"MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage2","dr_mutations_pyrazinamide","PRO",0,"ERS458600","ERR553184_ERR553183","lineage2.2.1","uz","Nukus","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760608","ERR760608","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR757160","ERR757160","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760740","ERR760740","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",NA,"MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR2510232","ERR2510232","lineage4.3.3","pe","Peru","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760748","ERR760748","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760812","ERR760812","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760892","ERR760892","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760792","ERR760792","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760920","ERR760920","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760910","ERR760910","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L2","PZA","Q","Q10",10,"P",1,"MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage2","dr_mutations_pyrazinamide","PRO",0,"ERS456779","ERR550664_ERR550663","lineage2.2.1","uz","Nukus","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760877","ERR760877","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760897","ERR760897","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760926","ERR760926","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760742","ERR760742","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760870","ERR760870","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760796","ERR760796","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760887","ERR760887","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L3","PZA","Q","Q10",10,"P",1,"MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage3","dr_mutations_pyrazinamide","PRO",0,"ERR2510456","ERR2510456","lineage3","pk","Pakistan","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760809","ERR760809","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10P","L4","PZA","Q","Q10",10,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",6.02,-1.771,-0.631,6.78299,-2.963,-0.11,95,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.0211297973264338,156.233890214797,156.233722233267,156.382472756358,1333.51093453962,38,-2,0,0,-2,0,0,0,0,6,2,4,0,0,0,0,0,-8,2,-6,-4,0,0,2,0,-0.448581560283688,-0.163049095607235,0.247051260571537,-0.505200341005968,-0.0287958115183246,1,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",5.05135310548255,2.49562215648785e-55,0.322395320006857,15.6681961306855,87.7376148601903,314.979076956589,2.19377524680641,1.27822918710216e-207,206.893391269988,83.6783303393677,330.782028899935,5.90060424845557e-292,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR760824","ERR760824","lineage4.1.2.1","ar","Argentina","pnca_p.gln10pro","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10R","L4","PZA","Q","Q10",10,"R",NA,"MDR","DM","hydrophilic","hydrophilic","neutral","basic","polar","pos",6.02,-0.833,-1.078,8.55341,-2.07,-0.42,94,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.001293661060802,83.0135478408129,83.0096797665738,82.9817212776157,70.7034697627924,-48,-32,0,0,-32,0,0,0,0,2,0,2,0,0,0,0,0,-5,0,-5,-5,0,0,6,-4,-0.210992907801418,-0.278552971576227,0.311533810706663,-0.352941176470588,-0.109947643979058,0.989473684210526,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",4.41895722469024,1.61039699449321e-05,1.02456224249978,4.31301978678098,17.0476857395373,1496.24228456829,1.91914897517566,1.31421065040623e-12,11.8813350175945,12.9924324330291,3402.15298704802,4.15161653132659e-17,"lineage4","dr_mutations_pyrazinamide","ARG",0,"SRR3732721","SRR3732721","lineage4.3.3","pe","Peru","pnca_p.gln10arg","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10R","L4","PZA","Q","Q10",10,"R",NA,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","basic","polar","pos",6.02,-0.833,-1.078,8.55341,-2.07,-0.42,94,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.001293661060802,83.0135478408129,83.0096797665738,82.9817212776157,70.7034697627924,-48,-32,0,0,-32,0,0,0,0,2,0,2,0,0,0,0,0,-5,0,-5,-5,0,0,6,-4,-0.210992907801418,-0.278552971576227,0.311533810706663,-0.352941176470588,-0.109947643979058,0.989473684210526,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",4.41895722469024,1.61039699449321e-05,1.02456224249978,4.31301978678098,17.0476857395373,1496.24228456829,1.91914897517566,1.31421065040623e-12,11.8813350175945,12.9924324330291,3402.15298704802,4.15161653132659e-17,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERR751503","ERR751503","lineage4.3.3","pe","","pnca_p.gln10arg","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10R","L4","PZA","Q","Q10",10,"R",NA,"MDR","DM","hydrophilic","hydrophilic","neutral","basic","polar","pos",6.02,-0.833,-1.078,8.55341,-2.07,-0.42,94,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.001293661060802,83.0135478408129,83.0096797665738,82.9817212776157,70.7034697627924,-48,-32,0,0,-32,0,0,0,0,2,0,2,0,0,0,0,0,-5,0,-5,-5,0,0,6,-4,-0.210992907801418,-0.278552971576227,0.311533810706663,-0.352941176470588,-0.109947643979058,0.989473684210526,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",4.41895722469024,1.61039699449321e-05,1.02456224249978,4.31301978678098,17.0476857395373,1496.24228456829,1.91914897517566,1.31421065040623e-12,11.8813350175945,12.9924324330291,3402.15298704802,4.15161653132659e-17,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERR751581","ERR751581","lineage4.3.3","pe","","pnca_p.gln10arg","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10R","L4","PZA","Q","Q10",10,"R",NA,"MDR","DM","hydrophilic","hydrophilic","neutral","basic","polar","pos",6.02,-0.833,-1.078,8.55341,-2.07,-0.42,94,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.001293661060802,83.0135478408129,83.0096797665738,82.9817212776157,70.7034697627924,-48,-32,0,0,-32,0,0,0,0,2,0,2,0,0,0,0,0,-5,0,-5,-5,0,0,6,-4,-0.210992907801418,-0.278552971576227,0.311533810706663,-0.352941176470588,-0.109947643979058,0.989473684210526,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",4.41895722469024,1.61039699449321e-05,1.02456224249978,4.31301978678098,17.0476857395373,1496.24228456829,1.91914897517566,1.31421065040623e-12,11.8813350175945,12.9924324330291,3402.15298704802,4.15161653132659e-17,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERR775369","ERR775369","lineage4.3.3","pe","","pnca_p.gln10arg","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10R","L4","PZA","Q","Q10",10,"R",NA,"MDR","DM","hydrophilic","hydrophilic","neutral","basic","polar","pos",6.02,-0.833,-1.078,8.55341,-2.07,-0.42,94,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.001293661060802,83.0135478408129,83.0096797665738,82.9817212776157,70.7034697627924,-48,-32,0,0,-32,0,0,0,0,2,0,2,0,0,0,0,0,-5,0,-5,-5,0,0,6,-4,-0.210992907801418,-0.278552971576227,0.311533810706663,-0.352941176470588,-0.109947643979058,0.989473684210526,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",4.41895722469024,1.61039699449321e-05,1.02456224249978,4.31301978678098,17.0476857395373,1496.24228456829,1.91914897517566,1.31421065040623e-12,11.8813350175945,12.9924324330291,3402.15298704802,4.15161653132659e-17,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERR2510167","ERR2510167","lineage4.3.3","pe","Peru","pnca_p.gln10arg","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10R","L4","PZA","Q","Q10",10,"R",NA,"MDR","DM","hydrophilic","hydrophilic","neutral","basic","polar","pos",6.02,-0.833,-1.078,8.55341,-2.07,-0.42,94,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.001293661060802,83.0135478408129,83.0096797665738,82.9817212776157,70.7034697627924,-48,-32,0,0,-32,0,0,0,0,2,0,2,0,0,0,0,0,-5,0,-5,-5,0,0,6,-4,-0.210992907801418,-0.278552971576227,0.311533810706663,-0.352941176470588,-0.109947643979058,0.989473684210526,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",4.41895722469024,1.61039699449321e-05,1.02456224249978,4.31301978678098,17.0476857395373,1496.24228456829,1.91914897517566,1.31421065040623e-12,11.8813350175945,12.9924324330291,3402.15298704802,4.15161653132659e-17,"lineage4","dr_mutations_pyrazinamide","ARG",0,"SRR7517831","SRR7517831","lineage4.3.3","pe","Peru","pnca_p.gln10arg","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10R","L2","PZA","Q","Q10",10,"R",0,"MDR","DM","hydrophilic","hydrophilic","neutral","basic","polar","pos",6.02,-0.833,-1.078,8.55341,-2.07,-0.42,94,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.001293661060802,83.0135478408129,83.0096797665738,82.9817212776157,70.7034697627924,-48,-32,0,0,-32,0,0,0,0,2,0,2,0,0,0,0,0,-5,0,-5,-5,0,0,6,-4,-0.210992907801418,-0.278552971576227,0.311533810706663,-0.352941176470588,-0.109947643979058,0.989473684210526,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",4.41895722469024,1.61039699449321e-05,1.02456224249978,4.31301978678098,17.0476857395373,1496.24228456829,1.91914897517566,1.31421065040623e-12,11.8813350175945,12.9924324330291,3402.15298704802,4.15161653132659e-17,"lineage2","dr_mutations_pyrazinamide","ARG",0,"SAMEA2533806,ERS457208","ERR551250_ERR551251","lineage2.2.1","uz","Nukus","pnca_p.gln10arg","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10R","L4","PZA","Q","Q10",10,"R",1,"MDR","DM","hydrophilic","hydrophilic","neutral","basic","polar","pos",6.02,-0.833,-1.078,8.55341,-2.07,-0.42,94,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.001293661060802,83.0135478408129,83.0096797665738,82.9817212776157,70.7034697627924,-48,-32,0,0,-32,0,0,0,0,2,0,2,0,0,0,0,0,-5,0,-5,-5,0,0,6,-4,-0.210992907801418,-0.278552971576227,0.311533810706663,-0.352941176470588,-0.109947643979058,0.989473684210526,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",4.41895722469024,1.61039699449321e-05,1.02456224249978,4.31301978678098,17.0476857395373,1496.24228456829,1.91914897517566,1.31421065040623e-12,11.8813350175945,12.9924324330291,3402.15298704802,4.15161653132659e-17,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERR2516528","ERR2516528","lineage4.3.3","pe","Peru","pnca_p.gln10arg","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10R","L4","PZA","Q","Q10",10,"R",NA,"MDR","DM","hydrophilic","hydrophilic","neutral","basic","polar","pos",6.02,-0.833,-1.078,8.55341,-2.07,-0.42,94,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.001293661060802,83.0135478408129,83.0096797665738,82.9817212776157,70.7034697627924,-48,-32,0,0,-32,0,0,0,0,2,0,2,0,0,0,0,0,-5,0,-5,-5,0,0,6,-4,-0.210992907801418,-0.278552971576227,0.311533810706663,-0.352941176470588,-0.109947643979058,0.989473684210526,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",4.41895722469024,1.61039699449321e-05,1.02456224249978,4.31301978678098,17.0476857395373,1496.24228456829,1.91914897517566,1.31421065040623e-12,11.8813350175945,12.9924324330291,3402.15298704802,4.15161653132659e-17,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERR1213928","ERR1213928","lineage4.3.3","pe","Peru","pnca_p.gln10arg","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10R","L2","PZA","Q","Q10",10,"R",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","basic","polar","pos",6.02,-0.833,-1.078,8.55341,-2.07,-0.42,94,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.001293661060802,83.0135478408129,83.0096797665738,82.9817212776157,70.7034697627924,-48,-32,0,0,-32,0,0,0,0,2,0,2,0,0,0,0,0,-5,0,-5,-5,0,0,6,-4,-0.210992907801418,-0.278552971576227,0.311533810706663,-0.352941176470588,-0.109947643979058,0.989473684210526,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",4.41895722469024,1.61039699449321e-05,1.02456224249978,4.31301978678098,17.0476857395373,1496.24228456829,1.91914897517566,1.31421065040623e-12,11.8813350175945,12.9924324330291,3402.15298704802,4.15161653132659e-17,"lineage2","dr_mutations_pyrazinamide","ARG",0,"SAMN10961326","SRR8651656","lineage2.2.1","cn","China:Wenzhou","pnca_p.gln10arg","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10R","L4","PZA","Q","Q10",10,"R",NA,"MDR","DM","hydrophilic","hydrophilic","neutral","basic","polar","pos",6.02,-0.833,-1.078,8.55341,-2.07,-0.42,94,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.001293661060802,83.0135478408129,83.0096797665738,82.9817212776157,70.7034697627924,-48,-32,0,0,-32,0,0,0,0,2,0,2,0,0,0,0,0,-5,0,-5,-5,0,0,6,-4,-0.210992907801418,-0.278552971576227,0.311533810706663,-0.352941176470588,-0.109947643979058,0.989473684210526,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",4.41895722469024,1.61039699449321e-05,1.02456224249978,4.31301978678098,17.0476857395373,1496.24228456829,1.91914897517566,1.31421065040623e-12,11.8813350175945,12.9924324330291,3402.15298704802,4.15161653132659e-17,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERR775311","ERR775311","lineage4.3.3","pe","","pnca_p.gln10arg","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10R","L2","PZA","Q","Q10",10,"R",NA,"XDR","DM","hydrophilic","hydrophilic","neutral","basic","polar","pos",6.02,-0.833,-1.078,8.55341,-2.07,-0.42,94,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.001293661060802,83.0135478408129,83.0096797665738,82.9817212776157,70.7034697627924,-48,-32,0,0,-32,0,0,0,0,2,0,2,0,0,0,0,0,-5,0,-5,-5,0,0,6,-4,-0.210992907801418,-0.278552971576227,0.311533810706663,-0.352941176470588,-0.109947643979058,0.989473684210526,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",4.41895722469024,1.61039699449321e-05,1.02456224249978,4.31301978678098,17.0476857395373,1496.24228456829,1.91914897517566,1.31421065040623e-12,11.8813350175945,12.9924324330291,3402.15298704802,4.15161653132659e-17,"lineage2","dr_mutations_pyrazinamide","ARG",0,"ERR158609","ERR158609","lineage2.2.1.1","gb","UK","pnca_p.gln10arg","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10R","L2","PZA","Q","Q10",10,"R",1,"MDR","DM","hydrophilic","hydrophilic","neutral","basic","polar","pos",6.02,-0.833,-1.078,8.55341,-2.07,-0.42,94,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.001293661060802,83.0135478408129,83.0096797665738,82.9817212776157,70.7034697627924,-48,-32,0,0,-32,0,0,0,0,2,0,2,0,0,0,0,0,-5,0,-5,-5,0,0,6,-4,-0.210992907801418,-0.278552971576227,0.311533810706663,-0.352941176470588,-0.109947643979058,0.989473684210526,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",4.41895722469024,1.61039699449321e-05,1.02456224249978,4.31301978678098,17.0476857395373,1496.24228456829,1.91914897517566,1.31421065040623e-12,11.8813350175945,12.9924324330291,3402.15298704802,4.15161653132659e-17,"lineage2","dr_mutations_pyrazinamide","ARG",0,"ERR2510305","ERR2510305","lineage2.2.1.1","pk","Pakistan","pnca_p.gln10arg","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10R","L4","PZA","Q","Q10",10,"R",NA,"MDR","DM","hydrophilic","hydrophilic","neutral","basic","polar","pos",6.02,-0.833,-1.078,8.55341,-2.07,-0.42,94,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.001293661060802,83.0135478408129,83.0096797665738,82.9817212776157,70.7034697627924,-48,-32,0,0,-32,0,0,0,0,2,0,2,0,0,0,0,0,-5,0,-5,-5,0,0,6,-4,-0.210992907801418,-0.278552971576227,0.311533810706663,-0.352941176470588,-0.109947643979058,0.989473684210526,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",4.41895722469024,1.61039699449321e-05,1.02456224249978,4.31301978678098,17.0476857395373,1496.24228456829,1.91914897517566,1.31421065040623e-12,11.8813350175945,12.9924324330291,3402.15298704802,4.15161653132659e-17,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERR751459","ERR751459","lineage4.3.3","pe","","pnca_p.gln10arg","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10R","L2","PZA","Q","Q10",10,"R",NA,"MDR","DM","hydrophilic","hydrophilic","neutral","basic","polar","pos",6.02,-0.833,-1.078,8.55341,-2.07,-0.42,94,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.001293661060802,83.0135478408129,83.0096797665738,82.9817212776157,70.7034697627924,-48,-32,0,0,-32,0,0,0,0,2,0,2,0,0,0,0,0,-5,0,-5,-5,0,0,6,-4,-0.210992907801418,-0.278552971576227,0.311533810706663,-0.352941176470588,-0.109947643979058,0.989473684210526,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",4.41895722469024,1.61039699449321e-05,1.02456224249978,4.31301978678098,17.0476857395373,1496.24228456829,1.91914897517566,1.31421065040623e-12,11.8813350175945,12.9924324330291,3402.15298704802,4.15161653132659e-17,"lineage2","dr_mutations_pyrazinamide","ARG",0,"DRR184607","DRR184607","lineage2.2.1","vn","Vietnam","pnca_p.gln10arg","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10R","L4","PZA","Q","Q10",10,"R",NA,"MDR","DM","hydrophilic","hydrophilic","neutral","basic","polar","pos",6.02,-0.833,-1.078,8.55341,-2.07,-0.42,94,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.001293661060802,83.0135478408129,83.0096797665738,82.9817212776157,70.7034697627924,-48,-32,0,0,-32,0,0,0,0,2,0,2,0,0,0,0,0,-5,0,-5,-5,0,0,6,-4,-0.210992907801418,-0.278552971576227,0.311533810706663,-0.352941176470588,-0.109947643979058,0.989473684210526,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",4.41895722469024,1.61039699449321e-05,1.02456224249978,4.31301978678098,17.0476857395373,1496.24228456829,1.91914897517566,1.31421065040623e-12,11.8813350175945,12.9924324330291,3402.15298704802,4.15161653132659e-17,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERR779895","ERR779895","lineage4.3.3","pe","","pnca_p.gln10arg","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10R","L4","PZA","Q","Q10",10,"R",1,"MDR","DM","hydrophilic","hydrophilic","neutral","basic","polar","pos",6.02,-0.833,-1.078,8.55341,-2.07,-0.42,94,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.001293661060802,83.0135478408129,83.0096797665738,82.9817212776157,70.7034697627924,-48,-32,0,0,-32,0,0,0,0,2,0,2,0,0,0,0,0,-5,0,-5,-5,0,0,6,-4,-0.210992907801418,-0.278552971576227,0.311533810706663,-0.352941176470588,-0.109947643979058,0.989473684210526,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",4.41895722469024,1.61039699449321e-05,1.02456224249978,4.31301978678098,17.0476857395373,1496.24228456829,1.91914897517566,1.31421065040623e-12,11.8813350175945,12.9924324330291,3402.15298704802,4.15161653132659e-17,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERR2516333","ERR2516333","lineage4.6.1.2","be","Belgium","pnca_p.gln10arg","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10R","L4","PZA","Q","Q10",10,"R",NA,"MDR","DM","hydrophilic","hydrophilic","neutral","basic","polar","pos",6.02,-0.833,-1.078,8.55341,-2.07,-0.42,94,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.001293661060802,83.0135478408129,83.0096797665738,82.9817212776157,70.7034697627924,-48,-32,0,0,-32,0,0,0,0,2,0,2,0,0,0,0,0,-5,0,-5,-5,0,0,6,-4,-0.210992907801418,-0.278552971576227,0.311533810706663,-0.352941176470588,-0.109947643979058,0.989473684210526,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",4.41895722469024,1.61039699449321e-05,1.02456224249978,4.31301978678098,17.0476857395373,1496.24228456829,1.91914897517566,1.31421065040623e-12,11.8813350175945,12.9924324330291,3402.15298704802,4.15161653132659e-17,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERR751399","ERR751399","lineage4.3.3","pe","","pnca_p.gln10arg","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10R","L2","PZA","Q","Q10",10,"R",1,"XDR","DM","hydrophilic","hydrophilic","neutral","basic","polar","pos",6.02,-0.833,-1.078,8.55341,-2.07,-0.42,94,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.001293661060802,83.0135478408129,83.0096797665738,82.9817212776157,70.7034697627924,-48,-32,0,0,-32,0,0,0,0,2,0,2,0,0,0,0,0,-5,0,-5,-5,0,0,6,-4,-0.210992907801418,-0.278552971576227,0.311533810706663,-0.352941176470588,-0.109947643979058,0.989473684210526,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",4.41895722469024,1.61039699449321e-05,1.02456224249978,4.31301978678098,17.0476857395373,1496.24228456829,1.91914897517566,1.31421065040623e-12,11.8813350175945,12.9924324330291,3402.15298704802,4.15161653132659e-17,"lineage2","dr_mutations_pyrazinamide","ARG",0,"ERR2516846","ERR2516846","lineage2.2.1.1","gb","UK","pnca_p.gln10arg","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10R","L4","PZA","Q","Q10",10,"R",NA,"MDR","DM","hydrophilic","hydrophilic","neutral","basic","polar","pos",6.02,-0.833,-1.078,8.55341,-2.07,-0.42,94,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.001293661060802,83.0135478408129,83.0096797665738,82.9817212776157,70.7034697627924,-48,-32,0,0,-32,0,0,0,0,2,0,2,0,0,0,0,0,-5,0,-5,-5,0,0,6,-4,-0.210992907801418,-0.278552971576227,0.311533810706663,-0.352941176470588,-0.109947643979058,0.989473684210526,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",4.41895722469024,1.61039699449321e-05,1.02456224249978,4.31301978678098,17.0476857395373,1496.24228456829,1.91914897517566,1.31421065040623e-12,11.8813350175945,12.9924324330291,3402.15298704802,4.15161653132659e-17,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERR779906","ERR779906","lineage4.3.3","pe","","pnca_p.gln10arg","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10R","L2","PZA","Q","Q10",10,"R",NA,"XDR","DM","hydrophilic","hydrophilic","neutral","basic","polar","pos",6.02,-0.833,-1.078,8.55341,-2.07,-0.42,94,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.001293661060802,83.0135478408129,83.0096797665738,82.9817212776157,70.7034697627924,-48,-32,0,0,-32,0,0,0,0,2,0,2,0,0,0,0,0,-5,0,-5,-5,0,0,6,-4,-0.210992907801418,-0.278552971576227,0.311533810706663,-0.352941176470588,-0.109947643979058,0.989473684210526,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",4.41895722469024,1.61039699449321e-05,1.02456224249978,4.31301978678098,17.0476857395373,1496.24228456829,1.91914897517566,1.31421065040623e-12,11.8813350175945,12.9924324330291,3402.15298704802,4.15161653132659e-17,"lineage2","dr_mutations_pyrazinamide","ARG",0,"SAMN02419610","SRR1163329_SRR1163290_SRR1169090_SRR1172367","lineage2.2.1","by","Belarus","pnca_p.gln10arg","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10R","L4","PZA","Q","Q10",10,"R",NA,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","basic","polar","pos",6.02,-0.833,-1.078,8.55341,-2.07,-0.42,94,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.001293661060802,83.0135478408129,83.0096797665738,82.9817212776157,70.7034697627924,-48,-32,0,0,-32,0,0,0,0,2,0,2,0,0,0,0,0,-5,0,-5,-5,0,0,6,-4,-0.210992907801418,-0.278552971576227,0.311533810706663,-0.352941176470588,-0.109947643979058,0.989473684210526,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",4.41895722469024,1.61039699449321e-05,1.02456224249978,4.31301978678098,17.0476857395373,1496.24228456829,1.91914897517566,1.31421065040623e-12,11.8813350175945,12.9924324330291,3402.15298704802,4.15161653132659e-17,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERR3276064","ERR3276064","lineage4.1.2.1","nl","Netherlands","pnca_p.gln10arg","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10R","L4","PZA","Q","Q10",10,"R",NA,"MDR","DM","hydrophilic","hydrophilic","neutral","basic","polar","pos",6.02,-0.833,-1.078,8.55341,-2.07,-0.42,94,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.001293661060802,83.0135478408129,83.0096797665738,82.9817212776157,70.7034697627924,-48,-32,0,0,-32,0,0,0,0,2,0,2,0,0,0,0,0,-5,0,-5,-5,0,0,6,-4,-0.210992907801418,-0.278552971576227,0.311533810706663,-0.352941176470588,-0.109947643979058,0.989473684210526,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",4.41895722469024,1.61039699449321e-05,1.02456224249978,4.31301978678098,17.0476857395373,1496.24228456829,1.91914897517566,1.31421065040623e-12,11.8813350175945,12.9924324330291,3402.15298704802,4.15161653132659e-17,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERR779847","ERR779847","lineage4.3.3","pe","","pnca_p.gln10arg","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10R","L4","PZA","Q","Q10",10,"R",NA,"MDR","DM","hydrophilic","hydrophilic","neutral","basic","polar","pos",6.02,-0.833,-1.078,8.55341,-2.07,-0.42,94,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.001293661060802,83.0135478408129,83.0096797665738,82.9817212776157,70.7034697627924,-48,-32,0,0,-32,0,0,0,0,2,0,2,0,0,0,0,0,-5,0,-5,-5,0,0,6,-4,-0.210992907801418,-0.278552971576227,0.311533810706663,-0.352941176470588,-0.109947643979058,0.989473684210526,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",4.41895722469024,1.61039699449321e-05,1.02456224249978,4.31301978678098,17.0476857395373,1496.24228456829,1.91914897517566,1.31421065040623e-12,11.8813350175945,12.9924324330291,3402.15298704802,4.15161653132659e-17,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERR775302","ERR775302","lineage4.3.3","pe","","pnca_p.gln10arg","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10R","L1","PZA","Q","Q10",10,"R",1,"MDR","DM","hydrophilic","hydrophilic","neutral","basic","polar","pos",6.02,-0.833,-1.078,8.55341,-2.07,-0.42,94,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.001293661060802,83.0135478408129,83.0096797665738,82.9817212776157,70.7034697627924,-48,-32,0,0,-32,0,0,0,0,2,0,2,0,0,0,0,0,-5,0,-5,-5,0,0,6,-4,-0.210992907801418,-0.278552971576227,0.311533810706663,-0.352941176470588,-0.109947643979058,0.989473684210526,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",4.41895722469024,1.61039699449321e-05,1.02456224249978,4.31301978678098,17.0476857395373,1496.24228456829,1.91914897517566,1.31421065040623e-12,11.8813350175945,12.9924324330291,3402.15298704802,4.15161653132659e-17,"lineage1","dr_mutations_pyrazinamide","ARG",0,"ERR550869","ERR550869","lineage1.2.2","sz","Swaziland","pnca_p.gln10arg","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10R","L4","PZA","Q","Q10",10,"R",NA,"MDR","DM","hydrophilic","hydrophilic","neutral","basic","polar","pos",6.02,-0.833,-1.078,8.55341,-2.07,-0.42,94,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.001293661060802,83.0135478408129,83.0096797665738,82.9817212776157,70.7034697627924,-48,-32,0,0,-32,0,0,0,0,2,0,2,0,0,0,0,0,-5,0,-5,-5,0,0,6,-4,-0.210992907801418,-0.278552971576227,0.311533810706663,-0.352941176470588,-0.109947643979058,0.989473684210526,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",4.41895722469024,1.61039699449321e-05,1.02456224249978,4.31301978678098,17.0476857395373,1496.24228456829,1.91914897517566,1.31421065040623e-12,11.8813350175945,12.9924324330291,3402.15298704802,4.15161653132659e-17,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERR751569","ERR751569","lineage4.3.3","pe","","pnca_p.gln10arg","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10R","L4","PZA","Q","Q10",10,"R",NA,"MDR","DM","hydrophilic","hydrophilic","neutral","basic","polar","pos",6.02,-0.833,-1.078,8.55341,-2.07,-0.42,94,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.001293661060802,83.0135478408129,83.0096797665738,82.9817212776157,70.7034697627924,-48,-32,0,0,-32,0,0,0,0,2,0,2,0,0,0,0,0,-5,0,-5,-5,0,0,6,-4,-0.210992907801418,-0.278552971576227,0.311533810706663,-0.352941176470588,-0.109947643979058,0.989473684210526,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",4.41895722469024,1.61039699449321e-05,1.02456224249978,4.31301978678098,17.0476857395373,1496.24228456829,1.91914897517566,1.31421065040623e-12,11.8813350175945,12.9924324330291,3402.15298704802,4.15161653132659e-17,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERR2707222","ERR2707222","lineage4.3.4.2.1","cd","Democratic Republic of Congo","pnca_p.gln10arg","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10R","L2","PZA","Q","Q10",10,"R",1,"XDR","DM","hydrophilic","hydrophilic","neutral","basic","polar","pos",6.02,-0.833,-1.078,8.55341,-2.07,-0.42,94,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.001293661060802,83.0135478408129,83.0096797665738,82.9817212776157,70.7034697627924,-48,-32,0,0,-32,0,0,0,0,2,0,2,0,0,0,0,0,-5,0,-5,-5,0,0,6,-4,-0.210992907801418,-0.278552971576227,0.311533810706663,-0.352941176470588,-0.109947643979058,0.989473684210526,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",4.41895722469024,1.61039699449321e-05,1.02456224249978,4.31301978678098,17.0476857395373,1496.24228456829,1.91914897517566,1.31421065040623e-12,11.8813350175945,12.9924324330291,3402.15298704802,4.15161653132659e-17,"lineage2","dr_mutations_pyrazinamide","ARG",0,"ERR2510252","ERR2510252","lineage2.2.1.1","pk","Pakistan","pnca_p.gln10arg","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10R","L4","PZA","Q","Q10",10,"R",1,"Pre-MDR","DM","hydrophilic","hydrophilic","neutral","basic","polar","pos",6.02,-0.833,-1.078,8.55341,-2.07,-0.42,94,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.001293661060802,83.0135478408129,83.0096797665738,82.9817212776157,70.7034697627924,-48,-32,0,0,-32,0,0,0,0,2,0,2,0,0,0,0,0,-5,0,-5,-5,0,0,6,-4,-0.210992907801418,-0.278552971576227,0.311533810706663,-0.352941176470588,-0.109947643979058,0.989473684210526,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",4.41895722469024,1.61039699449321e-05,1.02456224249978,4.31301978678098,17.0476857395373,1496.24228456829,1.91914897517566,1.31421065040623e-12,11.8813350175945,12.9924324330291,3402.15298704802,4.15161653132659e-17,"lineage4","dr_mutations_pyrazinamide","ARG",0,"MDR_23258","SRR6824366","lineage4.5","cn","China: Tongjiang County, Bazhong City, Sichuan Province ","pnca_p.gln10arg","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10R","L2","PZA","Q","Q10",10,"R",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","basic","polar","pos",6.02,-0.833,-1.078,8.55341,-2.07,-0.42,94,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.001293661060802,83.0135478408129,83.0096797665738,82.9817212776157,70.7034697627924,-48,-32,0,0,-32,0,0,0,0,2,0,2,0,0,0,0,0,-5,0,-5,-5,0,0,6,-4,-0.210992907801418,-0.278552971576227,0.311533810706663,-0.352941176470588,-0.109947643979058,0.989473684210526,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",4.41895722469024,1.61039699449321e-05,1.02456224249978,4.31301978678098,17.0476857395373,1496.24228456829,1.91914897517566,1.31421065040623e-12,11.8813350175945,12.9924324330291,3402.15298704802,4.15161653132659e-17,"lineage2","dr_mutations_pyrazinamide","ARG",0,"ERR2516644","ERR2516644","lineage2.2.1","pe","Peru","pnca_p.gln10arg","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10R","L4","PZA","Q","Q10",10,"R",NA,"MDR","DM","hydrophilic","hydrophilic","neutral","basic","polar","pos",6.02,-0.833,-1.078,8.55341,-2.07,-0.42,94,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.001293661060802,83.0135478408129,83.0096797665738,82.9817212776157,70.7034697627924,-48,-32,0,0,-32,0,0,0,0,2,0,2,0,0,0,0,0,-5,0,-5,-5,0,0,6,-4,-0.210992907801418,-0.278552971576227,0.311533810706663,-0.352941176470588,-0.109947643979058,0.989473684210526,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",4.41895722469024,1.61039699449321e-05,1.02456224249978,4.31301978678098,17.0476857395373,1496.24228456829,1.91914897517566,1.31421065040623e-12,11.8813350175945,12.9924324330291,3402.15298704802,4.15161653132659e-17,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERR775383","ERR775383","lineage4.3.3","pe","","pnca_p.gln10arg","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10R","L4","PZA","Q","Q10",10,"R",NA,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","basic","polar","pos",6.02,-0.833,-1.078,8.55341,-2.07,-0.42,94,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.001293661060802,83.0135478408129,83.0096797665738,82.9817212776157,70.7034697627924,-48,-32,0,0,-32,0,0,0,0,2,0,2,0,0,0,0,0,-5,0,-5,-5,0,0,6,-4,-0.210992907801418,-0.278552971576227,0.311533810706663,-0.352941176470588,-0.109947643979058,0.989473684210526,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",4.41895722469024,1.61039699449321e-05,1.02456224249978,4.31301978678098,17.0476857395373,1496.24228456829,1.91914897517566,1.31421065040623e-12,11.8813350175945,12.9924324330291,3402.15298704802,4.15161653132659e-17,"lineage4","dr_mutations_pyrazinamide","ARG",0,"SAMN02584584","SRR1168995_SRR1166305","lineage4.3.3","md","Moldova","pnca_p.gln10arg","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10R","L4","PZA","Q","Q10",10,"R",NA,"MDR","DM","hydrophilic","hydrophilic","neutral","basic","polar","pos",6.02,-0.833,-1.078,8.55341,-2.07,-0.42,94,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.001293661060802,83.0135478408129,83.0096797665738,82.9817212776157,70.7034697627924,-48,-32,0,0,-32,0,0,0,0,2,0,2,0,0,0,0,0,-5,0,-5,-5,0,0,6,-4,-0.210992907801418,-0.278552971576227,0.311533810706663,-0.352941176470588,-0.109947643979058,0.989473684210526,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",4.41895722469024,1.61039699449321e-05,1.02456224249978,4.31301978678098,17.0476857395373,1496.24228456829,1.91914897517566,1.31421065040623e-12,11.8813350175945,12.9924324330291,3402.15298704802,4.15161653132659e-17,"lineage4","dr_mutations_pyrazinamide","ARG",0,"SRR7517772","SRR7517772","lineage4.3.3","pe","Peru","pnca_p.gln10arg","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10R","L4","PZA","Q","Q10",10,"R",NA,"MDR","DM","hydrophilic","hydrophilic","neutral","basic","polar","pos",6.02,-0.833,-1.078,8.55341,-2.07,-0.42,94,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.001293661060802,83.0135478408129,83.0096797665738,82.9817212776157,70.7034697627924,-48,-32,0,0,-32,0,0,0,0,2,0,2,0,0,0,0,0,-5,0,-5,-5,0,0,6,-4,-0.210992907801418,-0.278552971576227,0.311533810706663,-0.352941176470588,-0.109947643979058,0.989473684210526,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",4.41895722469024,1.61039699449321e-05,1.02456224249978,4.31301978678098,17.0476857395373,1496.24228456829,1.91914897517566,1.31421065040623e-12,11.8813350175945,12.9924324330291,3402.15298704802,4.15161653132659e-17,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERR751462","ERR751462","lineage4.3.3","pe","","pnca_p.gln10arg","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10R","L4","PZA","Q","Q10",10,"R",1,"MDR","DM","hydrophilic","hydrophilic","neutral","basic","polar","pos",6.02,-0.833,-1.078,8.55341,-2.07,-0.42,94,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.001293661060802,83.0135478408129,83.0096797665738,82.9817212776157,70.7034697627924,-48,-32,0,0,-32,0,0,0,0,2,0,2,0,0,0,0,0,-5,0,-5,-5,0,0,6,-4,-0.210992907801418,-0.278552971576227,0.311533810706663,-0.352941176470588,-0.109947643979058,0.989473684210526,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",4.41895722469024,1.61039699449321e-05,1.02456224249978,4.31301978678098,17.0476857395373,1496.24228456829,1.91914897517566,1.31421065040623e-12,11.8813350175945,12.9924324330291,3402.15298704802,4.15161653132659e-17,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERR2516524","ERR2516524","lineage4.6.1.2","nl","Netherlands","pnca_p.gln10arg","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10R","L4","PZA","Q","Q10",10,"R",NA,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","basic","polar","pos",6.02,-0.833,-1.078,8.55341,-2.07,-0.42,94,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.001293661060802,83.0135478408129,83.0096797665738,82.9817212776157,70.7034697627924,-48,-32,0,0,-32,0,0,0,0,2,0,2,0,0,0,0,0,-5,0,-5,-5,0,0,6,-4,-0.210992907801418,-0.278552971576227,0.311533810706663,-0.352941176470588,-0.109947643979058,0.989473684210526,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",4.41895722469024,1.61039699449321e-05,1.02456224249978,4.31301978678098,17.0476857395373,1496.24228456829,1.91914897517566,1.31421065040623e-12,11.8813350175945,12.9924324330291,3402.15298704802,4.15161653132659e-17,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERR751564","ERR751564","lineage4.3.3","pe","","pnca_p.gln10arg","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10R","L2","PZA","Q","Q10",10,"R",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","basic","polar","pos",6.02,-0.833,-1.078,8.55341,-2.07,-0.42,94,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.001293661060802,83.0135478408129,83.0096797665738,82.9817212776157,70.7034697627924,-48,-32,0,0,-32,0,0,0,0,2,0,2,0,0,0,0,0,-5,0,-5,-5,0,0,6,-4,-0.210992907801418,-0.278552971576227,0.311533810706663,-0.352941176470588,-0.109947643979058,0.989473684210526,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",4.41895722469024,1.61039699449321e-05,1.02456224249978,4.31301978678098,17.0476857395373,1496.24228456829,1.91914897517566,1.31421065040623e-12,11.8813350175945,12.9924324330291,3402.15298704802,4.15161653132659e-17,"lineage2","dr_mutations_pyrazinamide","ARG",0,"ERR2510871","ERR2510871","lineage2.2.1.1","pk","Pakistan","pnca_p.gln10arg","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10R","L4","PZA","Q","Q10",10,"R",1,"MDR","DM","hydrophilic","hydrophilic","neutral","basic","polar","pos",6.02,-0.833,-1.078,8.55341,-2.07,-0.42,94,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.001293661060802,83.0135478408129,83.0096797665738,82.9817212776157,70.7034697627924,-48,-32,0,0,-32,0,0,0,0,2,0,2,0,0,0,0,0,-5,0,-5,-5,0,0,6,-4,-0.210992907801418,-0.278552971576227,0.311533810706663,-0.352941176470588,-0.109947643979058,0.989473684210526,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",4.41895722469024,1.61039699449321e-05,1.02456224249978,4.31301978678098,17.0476857395373,1496.24228456829,1.91914897517566,1.31421065040623e-12,11.8813350175945,12.9924324330291,3402.15298704802,4.15161653132659e-17,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERR2516504","ERR2516504","lineage4.3.3","pe","Peru","pnca_p.gln10arg","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10R","L4","PZA","Q","Q10",10,"R",NA,"MDR","DM","hydrophilic","hydrophilic","neutral","basic","polar","pos",6.02,-0.833,-1.078,8.55341,-2.07,-0.42,94,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.001293661060802,83.0135478408129,83.0096797665738,82.9817212776157,70.7034697627924,-48,-32,0,0,-32,0,0,0,0,2,0,2,0,0,0,0,0,-5,0,-5,-5,0,0,6,-4,-0.210992907801418,-0.278552971576227,0.311533810706663,-0.352941176470588,-0.109947643979058,0.989473684210526,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",4.41895722469024,1.61039699449321e-05,1.02456224249978,4.31301978678098,17.0476857395373,1496.24228456829,1.91914897517566,1.31421065040623e-12,11.8813350175945,12.9924324330291,3402.15298704802,4.15161653132659e-17,"lineage4","dr_mutations_pyrazinamide","ARG",0,"SRR7517810","SRR7517810","lineage4.3.3","pe","Peru","pnca_p.gln10arg","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10R","L2","PZA","Q","Q10",10,"R",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","basic","polar","pos",6.02,-0.833,-1.078,8.55341,-2.07,-0.42,94,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.001293661060802,83.0135478408129,83.0096797665738,82.9817212776157,70.7034697627924,-48,-32,0,0,-32,0,0,0,0,2,0,2,0,0,0,0,0,-5,0,-5,-5,0,0,6,-4,-0.210992907801418,-0.278552971576227,0.311533810706663,-0.352941176470588,-0.109947643979058,0.989473684210526,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",4.41895722469024,1.61039699449321e-05,1.02456224249978,4.31301978678098,17.0476857395373,1496.24228456829,1.91914897517566,1.31421065040623e-12,11.8813350175945,12.9924324330291,3402.15298704802,4.15161653132659e-17,"lineage2","dr_mutations_pyrazinamide","ARG",0,"ERR2516959","ERR2516959","lineage2.2.1.1","gb","UK","pnca_p.gln10arg","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10R","L4","PZA","Q","Q10",10,"R",NA,"MDR","DM","hydrophilic","hydrophilic","neutral","basic","polar","pos",6.02,-0.833,-1.078,8.55341,-2.07,-0.42,94,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.001293661060802,83.0135478408129,83.0096797665738,82.9817212776157,70.7034697627924,-48,-32,0,0,-32,0,0,0,0,2,0,2,0,0,0,0,0,-5,0,-5,-5,0,0,6,-4,-0.210992907801418,-0.278552971576227,0.311533810706663,-0.352941176470588,-0.109947643979058,0.989473684210526,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",4.41895722469024,1.61039699449321e-05,1.02456224249978,4.31301978678098,17.0476857395373,1496.24228456829,1.91914897517566,1.31421065040623e-12,11.8813350175945,12.9924324330291,3402.15298704802,4.15161653132659e-17,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERR751599","ERR751599","lineage4.3.3","pe","","pnca_p.gln10arg","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10R","L4","PZA","Q","Q10",10,"R",NA,"MDR","DM","hydrophilic","hydrophilic","neutral","basic","polar","pos",6.02,-0.833,-1.078,8.55341,-2.07,-0.42,94,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.001293661060802,83.0135478408129,83.0096797665738,82.9817212776157,70.7034697627924,-48,-32,0,0,-32,0,0,0,0,2,0,2,0,0,0,0,0,-5,0,-5,-5,0,0,6,-4,-0.210992907801418,-0.278552971576227,0.311533810706663,-0.352941176470588,-0.109947643979058,0.989473684210526,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",4.41895722469024,1.61039699449321e-05,1.02456224249978,4.31301978678098,17.0476857395373,1496.24228456829,1.91914897517566,1.31421065040623e-12,11.8813350175945,12.9924324330291,3402.15298704802,4.15161653132659e-17,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERR751604","ERR751604","lineage4.3.3","pe","","pnca_p.gln10arg","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10R","L4","PZA","Q","Q10",10,"R",NA,"MDR","DM","hydrophilic","hydrophilic","neutral","basic","polar","pos",6.02,-0.833,-1.078,8.55341,-2.07,-0.42,94,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.001293661060802,83.0135478408129,83.0096797665738,82.9817212776157,70.7034697627924,-48,-32,0,0,-32,0,0,0,0,2,0,2,0,0,0,0,0,-5,0,-5,-5,0,0,6,-4,-0.210992907801418,-0.278552971576227,0.311533810706663,-0.352941176470588,-0.109947643979058,0.989473684210526,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",4.41895722469024,1.61039699449321e-05,1.02456224249978,4.31301978678098,17.0476857395373,1496.24228456829,1.91914897517566,1.31421065040623e-12,11.8813350175945,12.9924324330291,3402.15298704802,4.15161653132659e-17,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERR751469","ERR751469","lineage4.3.3","pe","","pnca_p.gln10arg","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10R","L2","PZA","Q","Q10",10,"R",1,"MDR","DM","hydrophilic","hydrophilic","neutral","basic","polar","pos",6.02,-0.833,-1.078,8.55341,-2.07,-0.42,94,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.001293661060802,83.0135478408129,83.0096797665738,82.9817212776157,70.7034697627924,-48,-32,0,0,-32,0,0,0,0,2,0,2,0,0,0,0,0,-5,0,-5,-5,0,0,6,-4,-0.210992907801418,-0.278552971576227,0.311533810706663,-0.352941176470588,-0.109947643979058,0.989473684210526,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",4.41895722469024,1.61039699449321e-05,1.02456224249978,4.31301978678098,17.0476857395373,1496.24228456829,1.91914897517566,1.31421065040623e-12,11.8813350175945,12.9924324330291,3402.15298704802,4.15161653132659e-17,"lineage2","dr_mutations_pyrazinamide","ARG",0,"ERS458151","ERR552586_ERR552585","lineage2.2.1","uz","Nukus","pnca_p.gln10arg","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10R","L2","PZA","Q","Q10",10,"R",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","basic","polar","pos",6.02,-0.833,-1.078,8.55341,-2.07,-0.42,94,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.001293661060802,83.0135478408129,83.0096797665738,82.9817212776157,70.7034697627924,-48,-32,0,0,-32,0,0,0,0,2,0,2,0,0,0,0,0,-5,0,-5,-5,0,0,6,-4,-0.210992907801418,-0.278552971576227,0.311533810706663,-0.352941176470588,-0.109947643979058,0.989473684210526,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",4.41895722469024,1.61039699449321e-05,1.02456224249978,4.31301978678098,17.0476857395373,1496.24228456829,1.91914897517566,1.31421065040623e-12,11.8813350175945,12.9924324330291,3402.15298704802,4.15161653132659e-17,"lineage2","dr_mutations_pyrazinamide","ARG",0,"ERR2510870","ERR2510870","lineage2.2.1.1","pk","Pakistan","pnca_p.gln10arg","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10R","L2","PZA","Q","Q10",10,"R",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","basic","polar","pos",6.02,-0.833,-1.078,8.55341,-2.07,-0.42,94,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.001293661060802,83.0135478408129,83.0096797665738,82.9817212776157,70.7034697627924,-48,-32,0,0,-32,0,0,0,0,2,0,2,0,0,0,0,0,-5,0,-5,-5,0,0,6,-4,-0.210992907801418,-0.278552971576227,0.311533810706663,-0.352941176470588,-0.109947643979058,0.989473684210526,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",4.41895722469024,1.61039699449321e-05,1.02456224249978,4.31301978678098,17.0476857395373,1496.24228456829,1.91914897517566,1.31421065040623e-12,11.8813350175945,12.9924324330291,3402.15298704802,4.15161653132659e-17,"lineage2","dr_mutations_pyrazinamide","ARG",0,"ERR2516733","ERR2516733","lineage2.2.1","pe","Peru","pnca_p.gln10arg","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10R","L4","PZA","Q","Q10",10,"R",NA,"MDR","DM","hydrophilic","hydrophilic","neutral","basic","polar","pos",6.02,-0.833,-1.078,8.55341,-2.07,-0.42,94,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.001293661060802,83.0135478408129,83.0096797665738,82.9817212776157,70.7034697627924,-48,-32,0,0,-32,0,0,0,0,2,0,2,0,0,0,0,0,-5,0,-5,-5,0,0,6,-4,-0.210992907801418,-0.278552971576227,0.311533810706663,-0.352941176470588,-0.109947643979058,0.989473684210526,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",4.41895722469024,1.61039699449321e-05,1.02456224249978,4.31301978678098,17.0476857395373,1496.24228456829,1.91914897517566,1.31421065040623e-12,11.8813350175945,12.9924324330291,3402.15298704802,4.15161653132659e-17,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERR751472","ERR751472","lineage4.3.3","pe","","pnca_p.gln10arg","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10R","L4","PZA","Q","Q10",10,"R",NA,"MDR","DM","hydrophilic","hydrophilic","neutral","basic","polar","pos",6.02,-0.833,-1.078,8.55341,-2.07,-0.42,94,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.001293661060802,83.0135478408129,83.0096797665738,82.9817212776157,70.7034697627924,-48,-32,0,0,-32,0,0,0,0,2,0,2,0,0,0,0,0,-5,0,-5,-5,0,0,6,-4,-0.210992907801418,-0.278552971576227,0.311533810706663,-0.352941176470588,-0.109947643979058,0.989473684210526,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",4.41895722469024,1.61039699449321e-05,1.02456224249978,4.31301978678098,17.0476857395373,1496.24228456829,1.91914897517566,1.31421065040623e-12,11.8813350175945,12.9924324330291,3402.15298704802,4.15161653132659e-17,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERR751431","ERR751431","lineage4.3.3","pe","","pnca_p.gln10arg","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10R","L1","PZA","Q","Q10",10,"R",1,"MDR","DM","hydrophilic","hydrophilic","neutral","basic","polar","pos",6.02,-0.833,-1.078,8.55341,-2.07,-0.42,94,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.001293661060802,83.0135478408129,83.0096797665738,82.9817212776157,70.7034697627924,-48,-32,0,0,-32,0,0,0,0,2,0,2,0,0,0,0,0,-5,0,-5,-5,0,0,6,-4,-0.210992907801418,-0.278552971576227,0.311533810706663,-0.352941176470588,-0.109947643979058,0.989473684210526,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",4.41895722469024,1.61039699449321e-05,1.02456224249978,4.31301978678098,17.0476857395373,1496.24228456829,1.91914897517566,1.31421065040623e-12,11.8813350175945,12.9924324330291,3402.15298704802,4.15161653132659e-17,"lineage1","dr_mutations_pyrazinamide","ARG",0,"ERR551899","ERR551899","lineage1.2.2","sz","Swaziland","pnca_p.gln10arg","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10R","L4","PZA","Q","Q10",10,"R",NA,"MDR","DM","hydrophilic","hydrophilic","neutral","basic","polar","pos",6.02,-0.833,-1.078,8.55341,-2.07,-0.42,94,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.001293661060802,83.0135478408129,83.0096797665738,82.9817212776157,70.7034697627924,-48,-32,0,0,-32,0,0,0,0,2,0,2,0,0,0,0,0,-5,0,-5,-5,0,0,6,-4,-0.210992907801418,-0.278552971576227,0.311533810706663,-0.352941176470588,-0.109947643979058,0.989473684210526,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",4.41895722469024,1.61039699449321e-05,1.02456224249978,4.31301978678098,17.0476857395373,1496.24228456829,1.91914897517566,1.31421065040623e-12,11.8813350175945,12.9924324330291,3402.15298704802,4.15161653132659e-17,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERR751489","ERR751489","lineage4.3.3","pe","","pnca_p.gln10arg","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10R","L4","PZA","Q","Q10",10,"R",NA,"MDR","DM","hydrophilic","hydrophilic","neutral","basic","polar","pos",6.02,-0.833,-1.078,8.55341,-2.07,-0.42,94,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.001293661060802,83.0135478408129,83.0096797665738,82.9817212776157,70.7034697627924,-48,-32,0,0,-32,0,0,0,0,2,0,2,0,0,0,0,0,-5,0,-5,-5,0,0,6,-4,-0.210992907801418,-0.278552971576227,0.311533810706663,-0.352941176470588,-0.109947643979058,0.989473684210526,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",4.41895722469024,1.61039699449321e-05,1.02456224249978,4.31301978678098,17.0476857395373,1496.24228456829,1.91914897517566,1.31421065040623e-12,11.8813350175945,12.9924324330291,3402.15298704802,4.15161653132659e-17,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERR751429","ERR751429","lineage4.3.3","pe","","pnca_p.gln10arg","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10R","L4","PZA","Q","Q10",10,"R",NA,"XDR","DM","hydrophilic","hydrophilic","neutral","basic","polar","pos",6.02,-0.833,-1.078,8.55341,-2.07,-0.42,94,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.001293661060802,83.0135478408129,83.0096797665738,82.9817212776157,70.7034697627924,-48,-32,0,0,-32,0,0,0,0,2,0,2,0,0,0,0,0,-5,0,-5,-5,0,0,6,-4,-0.210992907801418,-0.278552971576227,0.311533810706663,-0.352941176470588,-0.109947643979058,0.989473684210526,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",4.41895722469024,1.61039699449321e-05,1.02456224249978,4.31301978678098,17.0476857395373,1496.24228456829,1.91914897517566,1.31421065040623e-12,11.8813350175945,12.9924324330291,3402.15298704802,4.15161653132659e-17,"lineage4","dr_mutations_pyrazinamide","ARG",0,"SRR7341648","SRR7341648","lineage4.1.2.1","ro","Romania","pnca_p.gln10arg","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10R","L4","PZA","Q","Q10",10,"R",NA,"MDR","DM","hydrophilic","hydrophilic","neutral","basic","polar","pos",6.02,-0.833,-1.078,8.55341,-2.07,-0.42,94,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.001293661060802,83.0135478408129,83.0096797665738,82.9817212776157,70.7034697627924,-48,-32,0,0,-32,0,0,0,0,2,0,2,0,0,0,0,0,-5,0,-5,-5,0,0,6,-4,-0.210992907801418,-0.278552971576227,0.311533810706663,-0.352941176470588,-0.109947643979058,0.989473684210526,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",4.41895722469024,1.61039699449321e-05,1.02456224249978,4.31301978678098,17.0476857395373,1496.24228456829,1.91914897517566,1.31421065040623e-12,11.8813350175945,12.9924324330291,3402.15298704802,4.15161653132659e-17,"lineage4","dr_mutations_pyrazinamide","ARG",0,"SAMN02381003","SRR1062893_SRR1049611_SRR1140702_SRR1049610","lineage4.3.4.2","ug","Uganda","pnca_p.gln10arg","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10R","L4","PZA","Q","Q10",10,"R",NA,"MDR","DM","hydrophilic","hydrophilic","neutral","basic","polar","pos",6.02,-0.833,-1.078,8.55341,-2.07,-0.42,94,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.001293661060802,83.0135478408129,83.0096797665738,82.9817212776157,70.7034697627924,-48,-32,0,0,-32,0,0,0,0,2,0,2,0,0,0,0,0,-5,0,-5,-5,0,0,6,-4,-0.210992907801418,-0.278552971576227,0.311533810706663,-0.352941176470588,-0.109947643979058,0.989473684210526,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",4.41895722469024,1.61039699449321e-05,1.02456224249978,4.31301978678098,17.0476857395373,1496.24228456829,1.91914897517566,1.31421065040623e-12,11.8813350175945,12.9924324330291,3402.15298704802,4.15161653132659e-17,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERR751424","ERR751424","lineage4.3.3","pe","","pnca_p.gln10arg","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10R","L4","PZA","Q","Q10",10,"R",NA,"MDR","DM","hydrophilic","hydrophilic","neutral","basic","polar","pos",6.02,-0.833,-1.078,8.55341,-2.07,-0.42,94,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.001293661060802,83.0135478408129,83.0096797665738,82.9817212776157,70.7034697627924,-48,-32,0,0,-32,0,0,0,0,2,0,2,0,0,0,0,0,-5,0,-5,-5,0,0,6,-4,-0.210992907801418,-0.278552971576227,0.311533810706663,-0.352941176470588,-0.109947643979058,0.989473684210526,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",4.41895722469024,1.61039699449321e-05,1.02456224249978,4.31301978678098,17.0476857395373,1496.24228456829,1.91914897517566,1.31421065040623e-12,11.8813350175945,12.9924324330291,3402.15298704802,4.15161653132659e-17,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERR751363","ERR751363","lineage4.3.3","pe","","pnca_p.gln10arg","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10R","L4","PZA","Q","Q10",10,"R",NA,"MDR","DM","hydrophilic","hydrophilic","neutral","basic","polar","pos",6.02,-0.833,-1.078,8.55341,-2.07,-0.42,94,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.001293661060802,83.0135478408129,83.0096797665738,82.9817212776157,70.7034697627924,-48,-32,0,0,-32,0,0,0,0,2,0,2,0,0,0,0,0,-5,0,-5,-5,0,0,6,-4,-0.210992907801418,-0.278552971576227,0.311533810706663,-0.352941176470588,-0.109947643979058,0.989473684210526,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",4.41895722469024,1.61039699449321e-05,1.02456224249978,4.31301978678098,17.0476857395373,1496.24228456829,1.91914897517566,1.31421065040623e-12,11.8813350175945,12.9924324330291,3402.15298704802,4.15161653132659e-17,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERR751460","ERR751460","lineage4.3.3","pe","","pnca_p.gln10arg","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10R","L2","PZA","Q","Q10",10,"R",NA,"XDR","DM","hydrophilic","hydrophilic","neutral","basic","polar","pos",6.02,-0.833,-1.078,8.55341,-2.07,-0.42,94,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.001293661060802,83.0135478408129,83.0096797665738,82.9817212776157,70.7034697627924,-48,-32,0,0,-32,0,0,0,0,2,0,2,0,0,0,0,0,-5,0,-5,-5,0,0,6,-4,-0.210992907801418,-0.278552971576227,0.311533810706663,-0.352941176470588,-0.109947643979058,0.989473684210526,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",4.41895722469024,1.61039699449321e-05,1.02456224249978,4.31301978678098,17.0476857395373,1496.24228456829,1.91914897517566,1.31421065040623e-12,11.8813350175945,12.9924324330291,3402.15298704802,4.15161653132659e-17,"lineage2","dr_mutations_pyrazinamide","ARG",0,"SAMN02419564","SRR1181104_SRR1181248_SRR1159370_SRR1158946","lineage2.2.1","by","Belarus","pnca_p.gln10arg","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"Q10R","L4","PZA","Q","Q10",10,"R",NA,"MDR","DM","hydrophilic","hydrophilic","neutral","basic","polar","pos",6.02,-0.833,-1.078,8.55341,-2.07,-0.42,94,95,-1.214,9,9,0,0,"strand",-0.933333333333333,8.14,0.001293661060802,83.0135478408129,83.0096797665738,82.9817212776157,70.7034697627924,-48,-32,0,0,-32,0,0,0,0,2,0,2,0,0,0,0,0,-5,0,-5,-5,0,0,6,-4,-0.210992907801418,-0.278552971576227,0.311533810706663,-0.352941176470588,-0.109947643979058,0.989473684210526,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","Q",4.41895722469024,1.61039699449321e-05,1.02456224249978,4.31301978678098,17.0476857395373,1496.24228456829,1.91914897517566,1.31421065040623e-12,11.8813350175945,12.9924324330291,3402.15298704802,4.15161653132659e-17,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERR751446","ERR751446","lineage4.3.3","pe","","pnca_p.gln10arg","A","B","GLN","QA10","pnca_complex.pdb"
|
|
"N11S","L3","PZA","N","N11",11,"S",0,"Sensitive","OM","hydrophilic","hydrophilic","neutral","neutral","polar","polar",9.599,-1.515,0.315,2.58536,-1.389,0.57,69,80,-0.682,8,8,42,0.215384615384615,"helix",-3.5,4.28,7.18700589334483e-05,2.42412778478352,0.0001249735077034,0,1.03410070803344e-29,4,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,-2,0,0,-2,0,0,-2,0,-0.383738601823708,0.267857142857143,0.094164438843523,-0.236828644501279,0.320224719101123,0.726315789473684,-0.561779242174629,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-0.827,-0.615,"8:7","147/150","T:P:L:N:V:I:R:K:Y:E:H:Q",-8.98740878149641,0.940032862253633,119.46804443549,-0.0752285585987755,NA,4692673.51081015,0.384555509373631,1,0,0,188.544222231268,0.999999999999997,"lineage3","other_mutations_pyrazinamide","SER",0,"ERR2513021","ERR2513021","lineage3","gb","UK","pnca_p.asn11ser","A","G","ASN","NA11","pnca_complex.pdb"
|
|
"D12A","L4","PZA","D","D12",12,"A",NA,"MDR","DM","hydrophilic","hydrophobic","acidic","non-polar","neg","non-polar",7.825,-2.924,0.904,0.896575,-1.267,1.36,64,80,-1.058,9,9,22,0.113989637305699,"helix",-1.4,5.01,0.0017967514733362,5.2760989010989,5.27609886875925,5.2752786493537,19.1276037177328,14,16,0,0,16,0,0,0,0,4,0,4,0,0,0,0,0,0,0,0,0,4,0,6,3,-0.740628166160081,0.768707482993197,0.0326552131061561,-0.216027280477408,0.764044943820225,0.673684210526316,-0.871499176276771,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.124,-1.028,"9:9","147/150","C:D:T:G",1.66318697401976,3.35314758209503e-05,0.400956055116994,4.14805301676878,2.39021356042842,11.7435962131774,0.722312927852139,6.93631068428177e-05,4.15887146261268,2.21601547098056,12.6651520546836,1.22263744860911e-05,"lineage4","dr_mutations_pyrazinamide","ALA",0,"ERR2707093","ERR2707093","lineage4.3.2","cd","Democratic Republic of Congo","pnca_p.asp12ala","A","G","ASP","DA12","pnca_complex.pdb"
|
|
"D12A","L2","PZA","D","D12",12,"A",1,"Pre-MDR","DM","hydrophilic","hydrophobic","acidic","non-polar","neg","non-polar",7.825,-2.924,0.904,0.896575,-1.267,1.36,64,80,-1.058,9,9,22,0.113989637305699,"helix",-1.4,5.01,0.0017967514733362,5.2760989010989,5.27609886875925,5.2752786493537,19.1276037177328,14,16,0,0,16,0,0,0,0,4,0,4,0,0,0,0,0,0,0,0,0,4,0,6,3,-0.740628166160081,0.768707482993197,0.0326552131061561,-0.216027280477408,0.764044943820225,0.673684210526316,-0.871499176276771,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.124,-1.028,"9:9","147/150","C:D:T:G",1.66318697401976,3.35314758209503e-05,0.400956055116994,4.14805301676878,2.39021356042842,11.7435962131774,0.722312927852139,6.93631068428177e-05,4.15887146261268,2.21601547098056,12.6651520546836,1.22263744860911e-05,"lineage2","dr_mutations_pyrazinamide","ALA",0,"ERR144545,1773D-sc-2012-02-21T11:37:23Z-1364782","ERR144545","lineage2.2.1","ru","Russia","pnca_p.asp12ala","A","G","ASP","DA12","pnca_complex.pdb"
|
|
"D12A","L4","PZA","D","D12",12,"A",NA,"MDR","DM","hydrophilic","hydrophobic","acidic","non-polar","neg","non-polar",7.825,-2.924,0.904,0.896575,-1.267,1.36,64,80,-1.058,9,9,22,0.113989637305699,"helix",-1.4,5.01,0.0017967514733362,5.2760989010989,5.27609886875925,5.2752786493537,19.1276037177328,14,16,0,0,16,0,0,0,0,4,0,4,0,0,0,0,0,0,0,0,0,4,0,6,3,-0.740628166160081,0.768707482993197,0.0326552131061561,-0.216027280477408,0.764044943820225,0.673684210526316,-0.871499176276771,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.124,-1.028,"9:9","147/150","C:D:T:G",1.66318697401976,3.35314758209503e-05,0.400956055116994,4.14805301676878,2.39021356042842,11.7435962131774,0.722312927852139,6.93631068428177e-05,4.15887146261268,2.21601547098056,12.6651520546836,1.22263744860911e-05,"lineage4","dr_mutations_pyrazinamide","ALA",0,"ERR1035281","ERR1035281","lineage4.3.4.1","br","Brazil","pnca_p.asp12ala","A","G","ASP","DA12","pnca_complex.pdb"
|
|
"D12A","L4","PZA","D","D12",12,"A",NA,"MDR","DM","hydrophilic","hydrophobic","acidic","non-polar","neg","non-polar",7.825,-2.924,0.904,0.896575,-1.267,1.36,64,80,-1.058,9,9,22,0.113989637305699,"helix",-1.4,5.01,0.0017967514733362,5.2760989010989,5.27609886875925,5.2752786493537,19.1276037177328,14,16,0,0,16,0,0,0,0,4,0,4,0,0,0,0,0,0,0,0,0,4,0,6,3,-0.740628166160081,0.768707482993197,0.0326552131061561,-0.216027280477408,0.764044943820225,0.673684210526316,-0.871499176276771,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.124,-1.028,"9:9","147/150","C:D:T:G",1.66318697401976,3.35314758209503e-05,0.400956055116994,4.14805301676878,2.39021356042842,11.7435962131774,0.722312927852139,6.93631068428177e-05,4.15887146261268,2.21601547098056,12.6651520546836,1.22263744860911e-05,"lineage4","dr_mutations_pyrazinamide","ALA",0,"ERR1199115","ERR1199115","lineage4.6.1.2","cd","Democratic Republic of the Congo","pnca_p.asp12ala","A","G","ASP","DA12","pnca_complex.pdb"
|
|
"D12A","L2","PZA","D","D12",12,"A",NA,"Other","DM","hydrophilic","hydrophobic","acidic","non-polar","neg","non-polar",7.825,-2.924,0.904,0.896575,-1.267,1.36,64,80,-1.058,9,9,22,0.113989637305699,"helix",-1.4,5.01,0.0017967514733362,5.2760989010989,5.27609886875925,5.2752786493537,19.1276037177328,14,16,0,0,16,0,0,0,0,4,0,4,0,0,0,0,0,0,0,0,0,4,0,6,3,-0.740628166160081,0.768707482993197,0.0326552131061561,-0.216027280477408,0.764044943820225,0.673684210526316,-0.871499176276771,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.124,-1.028,"9:9","147/150","C:D:T:G",1.66318697401976,3.35314758209503e-05,0.400956055116994,4.14805301676878,2.39021356042842,11.7435962131774,0.722312927852139,6.93631068428177e-05,4.15887146261268,2.21601547098056,12.6651520546836,1.22263744860911e-05,"lineage2","dr_mutations_pyrazinamide","ALA",0,"SRR5067707","SRR5067707","lineage2.2.1","vn","Vietnam","pnca_p.asp12ala","A","G","ASP","DA12","pnca_complex.pdb"
|
|
"D12A","L4","PZA","D","D12",12,"A",NA,"XDR","DM","hydrophilic","hydrophobic","acidic","non-polar","neg","non-polar",7.825,-2.924,0.904,0.896575,-1.267,1.36,64,80,-1.058,9,9,22,0.113989637305699,"helix",-1.4,5.01,0.0017967514733362,5.2760989010989,5.27609886875925,5.2752786493537,19.1276037177328,14,16,0,0,16,0,0,0,0,4,0,4,0,0,0,0,0,0,0,0,0,4,0,6,3,-0.740628166160081,0.768707482993197,0.0326552131061561,-0.216027280477408,0.764044943820225,0.673684210526316,-0.871499176276771,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.124,-1.028,"9:9","147/150","C:D:T:G",1.66318697401976,3.35314758209503e-05,0.400956055116994,4.14805301676878,2.39021356042842,11.7435962131774,0.722312927852139,6.93631068428177e-05,4.15887146261268,2.21601547098056,12.6651520546836,1.22263744860911e-05,"lineage4","dr_mutations_pyrazinamide","ALA",0,"SAMN01925647","SRR924218_SRR847803","lineage4.1.1.3","za","South Africa","pnca_p.asp12ala","A","G","ASP","DA12","pnca_complex.pdb"
|
|
"D12A","L4","PZA","D","D12",12,"A",NA,"MDR","DM","hydrophilic","hydrophobic","acidic","non-polar","neg","non-polar",7.825,-2.924,0.904,0.896575,-1.267,1.36,64,80,-1.058,9,9,22,0.113989637305699,"helix",-1.4,5.01,0.0017967514733362,5.2760989010989,5.27609886875925,5.2752786493537,19.1276037177328,14,16,0,0,16,0,0,0,0,4,0,4,0,0,0,0,0,0,0,0,0,4,0,6,3,-0.740628166160081,0.768707482993197,0.0326552131061561,-0.216027280477408,0.764044943820225,0.673684210526316,-0.871499176276771,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.124,-1.028,"9:9","147/150","C:D:T:G",1.66318697401976,3.35314758209503e-05,0.400956055116994,4.14805301676878,2.39021356042842,11.7435962131774,0.722312927852139,6.93631068428177e-05,4.15887146261268,2.21601547098056,12.6651520546836,1.22263744860911e-05,"lineage4","dr_mutations_pyrazinamide","ALA",0,"ERR2707118","ERR2707118","lineage4.3.2","cd","Democratic Republic of Congo","pnca_p.asp12ala","A","G","ASP","DA12","pnca_complex.pdb"
|
|
"D12A","L4","PZA","D","D12",12,"A",1,"MDR","DM","hydrophilic","hydrophobic","acidic","non-polar","neg","non-polar",7.825,-2.924,0.904,0.896575,-1.267,1.36,64,80,-1.058,9,9,22,0.113989637305699,"helix",-1.4,5.01,0.0017967514733362,5.2760989010989,5.27609886875925,5.2752786493537,19.1276037177328,14,16,0,0,16,0,0,0,0,4,0,4,0,0,0,0,0,0,0,0,0,4,0,6,3,-0.740628166160081,0.768707482993197,0.0326552131061561,-0.216027280477408,0.764044943820225,0.673684210526316,-0.871499176276771,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.124,-1.028,"9:9","147/150","C:D:T:G",1.66318697401976,3.35314758209503e-05,0.400956055116994,4.14805301676878,2.39021356042842,11.7435962131774,0.722312927852139,6.93631068428177e-05,4.15887146261268,2.21601547098056,12.6651520546836,1.22263744860911e-05,"lineage4","dr_mutations_pyrazinamide","ALA",0,"ERR038739","ERR038739","lineage4.6.1.2","ug","Uganda","pnca_p.asp12ala","A","G","ASP","DA12","pnca_complex.pdb"
|
|
"D12A","L1","PZA","D","D12",12,"A",0,"MDR","DM","hydrophilic","hydrophobic","acidic","non-polar","neg","non-polar",7.825,-2.924,0.904,0.896575,-1.267,1.36,64,80,-1.058,9,9,22,0.113989637305699,"helix",-1.4,5.01,0.0017967514733362,5.2760989010989,5.27609886875925,5.2752786493537,19.1276037177328,14,16,0,0,16,0,0,0,0,4,0,4,0,0,0,0,0,0,0,0,0,4,0,6,3,-0.740628166160081,0.768707482993197,0.0326552131061561,-0.216027280477408,0.764044943820225,0.673684210526316,-0.871499176276771,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.124,-1.028,"9:9","147/150","C:D:T:G",1.66318697401976,3.35314758209503e-05,0.400956055116994,4.14805301676878,2.39021356042842,11.7435962131774,0.722312927852139,6.93631068428177e-05,4.15887146261268,2.21601547098056,12.6651520546836,1.22263744860911e-05,"lineage1","dr_mutations_pyrazinamide","ALA",0,"ERR2516828","ERR2516828","lineage1.2.2","gb","UK","pnca_p.asp12ala","A","G","ASP","DA12","pnca_complex.pdb"
|
|
"D12A","L4","PZA","D","D12",12,"A",NA,"MDR","DM","hydrophilic","hydrophobic","acidic","non-polar","neg","non-polar",7.825,-2.924,0.904,0.896575,-1.267,1.36,64,80,-1.058,9,9,22,0.113989637305699,"helix",-1.4,5.01,0.0017967514733362,5.2760989010989,5.27609886875925,5.2752786493537,19.1276037177328,14,16,0,0,16,0,0,0,0,4,0,4,0,0,0,0,0,0,0,0,0,4,0,6,3,-0.740628166160081,0.768707482993197,0.0326552131061561,-0.216027280477408,0.764044943820225,0.673684210526316,-0.871499176276771,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.124,-1.028,"9:9","147/150","C:D:T:G",1.66318697401976,3.35314758209503e-05,0.400956055116994,4.14805301676878,2.39021356042842,11.7435962131774,0.722312927852139,6.93631068428177e-05,4.15887146261268,2.21601547098056,12.6651520546836,1.22263744860911e-05,"lineage4","dr_mutations_pyrazinamide","ALA",0,"ERR2706918","ERR2706918","lineage4.3.2","cd","Democratic Republic of Congo","pnca_p.asp12ala","A","G","ASP","DA12","pnca_complex.pdb"
|
|
"D12A","L2","PZA","D","D12",12,"A",NA,"XDR","DM","hydrophilic","hydrophobic","acidic","non-polar","neg","non-polar",7.825,-2.924,0.904,0.896575,-1.267,1.36,64,80,-1.058,9,9,22,0.113989637305699,"helix",-1.4,5.01,0.0017967514733362,5.2760989010989,5.27609886875925,5.2752786493537,19.1276037177328,14,16,0,0,16,0,0,0,0,4,0,4,0,0,0,0,0,0,0,0,0,4,0,6,3,-0.740628166160081,0.768707482993197,0.0326552131061561,-0.216027280477408,0.764044943820225,0.673684210526316,-0.871499176276771,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.124,-1.028,"9:9","147/150","C:D:T:G",1.66318697401976,3.35314758209503e-05,0.400956055116994,4.14805301676878,2.39021356042842,11.7435962131774,0.722312927852139,6.93631068428177e-05,4.15887146261268,2.21601547098056,12.6651520546836,1.22263744860911e-05,"lineage2","dr_mutations_pyrazinamide","ALA",0,"SAMN02584596","SRR1169159_SRR1166303","lineage2.2.1","md","Moldova","pnca_p.asp12ala","A","G","ASP","DA12","pnca_complex.pdb"
|
|
"D12A","L4","PZA","D","D12",12,"A",0,"Pre-XDR","DM","hydrophilic","hydrophobic","acidic","non-polar","neg","non-polar",7.825,-2.924,0.904,0.896575,-1.267,1.36,64,80,-1.058,9,9,22,0.113989637305699,"helix",-1.4,5.01,0.0017967514733362,5.2760989010989,5.27609886875925,5.2752786493537,19.1276037177328,14,16,0,0,16,0,0,0,0,4,0,4,0,0,0,0,0,0,0,0,0,4,0,6,3,-0.740628166160081,0.768707482993197,0.0326552131061561,-0.216027280477408,0.764044943820225,0.673684210526316,-0.871499176276771,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.124,-1.028,"9:9","147/150","C:D:T:G",1.66318697401976,3.35314758209503e-05,0.400956055116994,4.14805301676878,2.39021356042842,11.7435962131774,0.722312927852139,6.93631068428177e-05,4.15887146261268,2.21601547098056,12.6651520546836,1.22263744860911e-05,"lineage4","dr_mutations_pyrazinamide","ALA",0,"ERR2516419","ERR2516419","lineage4.3.3","nl","Netherlands","pnca_p.asp12ala","A","G","ASP","DA12","pnca_complex.pdb"
|
|
"D12A","L2","PZA","D","D12",12,"A",NA,"Pre-XDR","DM","hydrophilic","hydrophobic","acidic","non-polar","neg","non-polar",7.825,-2.924,0.904,0.896575,-1.267,1.36,64,80,-1.058,9,9,22,0.113989637305699,"helix",-1.4,5.01,0.0017967514733362,5.2760989010989,5.27609886875925,5.2752786493537,19.1276037177328,14,16,0,0,16,0,0,0,0,4,0,4,0,0,0,0,0,0,0,0,0,4,0,6,3,-0.740628166160081,0.768707482993197,0.0326552131061561,-0.216027280477408,0.764044943820225,0.673684210526316,-0.871499176276771,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.124,-1.028,"9:9","147/150","C:D:T:G",1.66318697401976,3.35314758209503e-05,0.400956055116994,4.14805301676878,2.39021356042842,11.7435962131774,0.722312927852139,6.93631068428177e-05,4.15887146261268,2.21601547098056,12.6651520546836,1.22263744860911e-05,"lineage2","dr_mutations_pyrazinamide","ALA",0,"SAMN02419561","SRR1180937_SRR1159977_SRR1159700_SRR1184120","lineage2.2.1","by","Belarus","pnca_p.asp12ala","A","G","ASP","DA12","pnca_complex.pdb"
|
|
"D12A","L2","PZA","D","D12",12,"A",0,"MDR","DM","hydrophilic","hydrophobic","acidic","non-polar","neg","non-polar",7.825,-2.924,0.904,0.896575,-1.267,1.36,64,80,-1.058,9,9,22,0.113989637305699,"helix",-1.4,5.01,0.0017967514733362,5.2760989010989,5.27609886875925,5.2752786493537,19.1276037177328,14,16,0,0,16,0,0,0,0,4,0,4,0,0,0,0,0,0,0,0,0,4,0,6,3,-0.740628166160081,0.768707482993197,0.0326552131061561,-0.216027280477408,0.764044943820225,0.673684210526316,-0.871499176276771,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.124,-1.028,"9:9","147/150","C:D:T:G",1.66318697401976,3.35314758209503e-05,0.400956055116994,4.14805301676878,2.39021356042842,11.7435962131774,0.722312927852139,6.93631068428177e-05,4.15887146261268,2.21601547098056,12.6651520546836,1.22263744860911e-05,"lineage2","dr_mutations_pyrazinamide","ALA",0,"ERR2516843","ERR2516843","lineage2.2.1","gb","UK","pnca_p.asp12ala","A","G","ASP","DA12","pnca_complex.pdb"
|
|
"D12A","L4","PZA","D","D12",12,"A",NA,"MDR","DM","hydrophilic","hydrophobic","acidic","non-polar","neg","non-polar",7.825,-2.924,0.904,0.896575,-1.267,1.36,64,80,-1.058,9,9,22,0.113989637305699,"helix",-1.4,5.01,0.0017967514733362,5.2760989010989,5.27609886875925,5.2752786493537,19.1276037177328,14,16,0,0,16,0,0,0,0,4,0,4,0,0,0,0,0,0,0,0,0,4,0,6,3,-0.740628166160081,0.768707482993197,0.0326552131061561,-0.216027280477408,0.764044943820225,0.673684210526316,-0.871499176276771,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.124,-1.028,"9:9","147/150","C:D:T:G",1.66318697401976,3.35314758209503e-05,0.400956055116994,4.14805301676878,2.39021356042842,11.7435962131774,0.722312927852139,6.93631068428177e-05,4.15887146261268,2.21601547098056,12.6651520546836,1.22263744860911e-05,"lineage4","dr_mutations_pyrazinamide","ALA",0,"ERR2179641","ERR2179641","lineage4.5","cn","China","pnca_p.asp12ala","A","G","ASP","DA12","pnca_complex.pdb"
|
|
"D12A","L4","PZA","D","D12",12,"A",NA,"XDR","DM","hydrophilic","hydrophobic","acidic","non-polar","neg","non-polar",7.825,-2.924,0.904,0.896575,-1.267,1.36,64,80,-1.058,9,9,22,0.113989637305699,"helix",-1.4,5.01,0.0017967514733362,5.2760989010989,5.27609886875925,5.2752786493537,19.1276037177328,14,16,0,0,16,0,0,0,0,4,0,4,0,0,0,0,0,0,0,0,0,4,0,6,3,-0.740628166160081,0.768707482993197,0.0326552131061561,-0.216027280477408,0.764044943820225,0.673684210526316,-0.871499176276771,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.124,-1.028,"9:9","147/150","C:D:T:G",1.66318697401976,3.35314758209503e-05,0.400956055116994,4.14805301676878,2.39021356042842,11.7435962131774,0.722312927852139,6.93631068428177e-05,4.15887146261268,2.21601547098056,12.6651520546836,1.22263744860911e-05,"lineage4","dr_mutations_pyrazinamide","ALA",0,"SAMN02584613","SRR1166082_SRR1169022","lineage4.2.1","md","Moldova","pnca_p.asp12ala","A","G","ASP","DA12","pnca_complex.pdb"
|
|
"D12A","L4","PZA","D","D12",12,"A",0,"MDR","DM","hydrophilic","hydrophobic","acidic","non-polar","neg","non-polar",7.825,-2.924,0.904,0.896575,-1.267,1.36,64,80,-1.058,9,9,22,0.113989637305699,"helix",-1.4,5.01,0.0017967514733362,5.2760989010989,5.27609886875925,5.2752786493537,19.1276037177328,14,16,0,0,16,0,0,0,0,4,0,4,0,0,0,0,0,0,0,0,0,4,0,6,3,-0.740628166160081,0.768707482993197,0.0326552131061561,-0.216027280477408,0.764044943820225,0.673684210526316,-0.871499176276771,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.124,-1.028,"9:9","147/150","C:D:T:G",1.66318697401976,3.35314758209503e-05,0.400956055116994,4.14805301676878,2.39021356042842,11.7435962131774,0.722312927852139,6.93631068428177e-05,4.15887146261268,2.21601547098056,12.6651520546836,1.22263744860911e-05,"lineage4","dr_mutations_pyrazinamide","ALA",0,"ERR2516410","ERR2516410","lineage4.2.1","nl","Netherlands","pnca_p.asp12ala","A","G","ASP","DA12","pnca_complex.pdb"
|
|
"D12A","L1","PZA","D","D12",12,"A",NA,"Pre-MDR","DM","hydrophilic","hydrophobic","acidic","non-polar","neg","non-polar",7.825,-2.924,0.904,0.896575,-1.267,1.36,64,80,-1.058,9,9,22,0.113989637305699,"helix",-1.4,5.01,0.0017967514733362,5.2760989010989,5.27609886875925,5.2752786493537,19.1276037177328,14,16,0,0,16,0,0,0,0,4,0,4,0,0,0,0,0,0,0,0,0,4,0,6,3,-0.740628166160081,0.768707482993197,0.0326552131061561,-0.216027280477408,0.764044943820225,0.673684210526316,-0.871499176276771,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.124,-1.028,"9:9","147/150","C:D:T:G",1.66318697401976,3.35314758209503e-05,0.400956055116994,4.14805301676878,2.39021356042842,11.7435962131774,0.722312927852139,6.93631068428177e-05,4.15887146261268,2.21601547098056,12.6651520546836,1.22263744860911e-05,"lineage1","dr_mutations_pyrazinamide","ALA",0,"ERR3256168","ERR3256168","lineage1.2.1","ph","Philippines","pnca_p.asp12ala","A","G","ASP","DA12","pnca_complex.pdb"
|
|
"D12A","L4","PZA","D","D12",12,"A",NA,"MDR","DM","hydrophilic","hydrophobic","acidic","non-polar","neg","non-polar",7.825,-2.924,0.904,0.896575,-1.267,1.36,64,80,-1.058,9,9,22,0.113989637305699,"helix",-1.4,5.01,0.0017967514733362,5.2760989010989,5.27609886875925,5.2752786493537,19.1276037177328,14,16,0,0,16,0,0,0,0,4,0,4,0,0,0,0,0,0,0,0,0,4,0,6,3,-0.740628166160081,0.768707482993197,0.0326552131061561,-0.216027280477408,0.764044943820225,0.673684210526316,-0.871499176276771,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.124,-1.028,"9:9","147/150","C:D:T:G",1.66318697401976,3.35314758209503e-05,0.400956055116994,4.14805301676878,2.39021356042842,11.7435962131774,0.722312927852139,6.93631068428177e-05,4.15887146261268,2.21601547098056,12.6651520546836,1.22263744860911e-05,"lineage4","dr_mutations_pyrazinamide","ALA",0,"ERR751547","ERR751547","lineage4.3.4.2","pe","","pnca_p.asp12ala","A","G","ASP","DA12","pnca_complex.pdb"
|
|
"D12A","L1","PZA","D","D12",12,"A",1,"MDR","DM","hydrophilic","hydrophobic","acidic","non-polar","neg","non-polar",7.825,-2.924,0.904,0.896575,-1.267,1.36,64,80,-1.058,9,9,22,0.113989637305699,"helix",-1.4,5.01,0.0017967514733362,5.2760989010989,5.27609886875925,5.2752786493537,19.1276037177328,14,16,0,0,16,0,0,0,0,4,0,4,0,0,0,0,0,0,0,0,0,4,0,6,3,-0.740628166160081,0.768707482993197,0.0326552131061561,-0.216027280477408,0.764044943820225,0.673684210526316,-0.871499176276771,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.124,-1.028,"9:9","147/150","C:D:T:G",1.66318697401976,3.35314758209503e-05,0.400956055116994,4.14805301676878,2.39021356042842,11.7435962131774,0.722312927852139,6.93631068428177e-05,4.15887146261268,2.21601547098056,12.6651520546836,1.22263744860911e-05,"lineage1","dr_mutations_pyrazinamide","ALA",0,"ERR2510512","ERR2510512","lineage1.2.2","pk","Pakistan","pnca_p.asp12ala","A","G","ASP","DA12","pnca_complex.pdb"
|
|
"D12A","L3","PZA","D","D12",12,"A",1,"MDR","DM","hydrophilic","hydrophobic","acidic","non-polar","neg","non-polar",7.825,-2.924,0.904,0.896575,-1.267,1.36,64,80,-1.058,9,9,22,0.113989637305699,"helix",-1.4,5.01,0.0017967514733362,5.2760989010989,5.27609886875925,5.2752786493537,19.1276037177328,14,16,0,0,16,0,0,0,0,4,0,4,0,0,0,0,0,0,0,0,0,4,0,6,3,-0.740628166160081,0.768707482993197,0.0326552131061561,-0.216027280477408,0.764044943820225,0.673684210526316,-0.871499176276771,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.124,-1.028,"9:9","147/150","C:D:T:G",1.66318697401976,3.35314758209503e-05,0.400956055116994,4.14805301676878,2.39021356042842,11.7435962131774,0.722312927852139,6.93631068428177e-05,4.15887146261268,2.21601547098056,12.6651520546836,1.22263744860911e-05,"lineage3","dr_mutations_pyrazinamide","ALA",0,"ERR3335759","ERR3335759","lineage3","pk","Pakistan","pnca_p.asp12ala","A","G","ASP","DA12","pnca_complex.pdb"
|
|
"D12A","L2","PZA","D","D12",12,"A",1,"XDR","DM","hydrophilic","hydrophobic","acidic","non-polar","neg","non-polar",7.825,-2.924,0.904,0.896575,-1.267,1.36,64,80,-1.058,9,9,22,0.113989637305699,"helix",-1.4,5.01,0.0017967514733362,5.2760989010989,5.27609886875925,5.2752786493537,19.1276037177328,14,16,0,0,16,0,0,0,0,4,0,4,0,0,0,0,0,0,0,0,0,4,0,6,3,-0.740628166160081,0.768707482993197,0.0326552131061561,-0.216027280477408,0.764044943820225,0.673684210526316,-0.871499176276771,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.124,-1.028,"9:9","147/150","C:D:T:G",1.66318697401976,3.35314758209503e-05,0.400956055116994,4.14805301676878,2.39021356042842,11.7435962131774,0.722312927852139,6.93631068428177e-05,4.15887146261268,2.21601547098056,12.6651520546836,1.22263744860911e-05,"lineage2","dr_mutations_pyrazinamide","ALA",0,"SRR2101053,SAMN03648300","SRR2101053","lineage2.2.1","","","pnca_p.asp12ala","A","G","ASP","DA12","pnca_complex.pdb"
|
|
"D12A","L4","PZA","D","D12",12,"A",NA,"MDR","DM","hydrophilic","hydrophobic","acidic","non-polar","neg","non-polar",7.825,-2.924,0.904,0.896575,-1.267,1.36,64,80,-1.058,9,9,22,0.113989637305699,"helix",-1.4,5.01,0.0017967514733362,5.2760989010989,5.27609886875925,5.2752786493537,19.1276037177328,14,16,0,0,16,0,0,0,0,4,0,4,0,0,0,0,0,0,0,0,0,4,0,6,3,-0.740628166160081,0.768707482993197,0.0326552131061561,-0.216027280477408,0.764044943820225,0.673684210526316,-0.871499176276771,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.124,-1.028,"9:9","147/150","C:D:T:G",1.66318697401976,3.35314758209503e-05,0.400956055116994,4.14805301676878,2.39021356042842,11.7435962131774,0.722312927852139,6.93631068428177e-05,4.15887146261268,2.21601547098056,12.6651520546836,1.22263744860911e-05,"lineage4","dr_mutations_pyrazinamide","ALA",0,"ERR2707164","ERR2707164","lineage4.3.2","cd","Democratic Republic of Congo","pnca_p.asp12ala","A","G","ASP","DA12","pnca_complex.pdb"
|
|
"D12A","L3","PZA","D","D12",12,"A",0,"Pre-MDR","DM","hydrophilic","hydrophobic","acidic","non-polar","neg","non-polar",7.825,-2.924,0.904,0.896575,-1.267,1.36,64,80,-1.058,9,9,22,0.113989637305699,"helix",-1.4,5.01,0.0017967514733362,5.2760989010989,5.27609886875925,5.2752786493537,19.1276037177328,14,16,0,0,16,0,0,0,0,4,0,4,0,0,0,0,0,0,0,0,0,4,0,6,3,-0.740628166160081,0.768707482993197,0.0326552131061561,-0.216027280477408,0.764044943820225,0.673684210526316,-0.871499176276771,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.124,-1.028,"9:9","147/150","C:D:T:G",1.66318697401976,3.35314758209503e-05,0.400956055116994,4.14805301676878,2.39021356042842,11.7435962131774,0.722312927852139,6.93631068428177e-05,4.15887146261268,2.21601547098056,12.6651520546836,1.22263744860911e-05,"lineage3","dr_mutations_pyrazinamide","ALA",0,"ERR2510646","ERR2510646","lineage3","pk","Pakistan","pnca_p.asp12ala","A","G","ASP","DA12","pnca_complex.pdb"
|
|
"D12A","L4","PZA","D","D12",12,"A",NA,"MDR","DM","hydrophilic","hydrophobic","acidic","non-polar","neg","non-polar",7.825,-2.924,0.904,0.896575,-1.267,1.36,64,80,-1.058,9,9,22,0.113989637305699,"helix",-1.4,5.01,0.0017967514733362,5.2760989010989,5.27609886875925,5.2752786493537,19.1276037177328,14,16,0,0,16,0,0,0,0,4,0,4,0,0,0,0,0,0,0,0,0,4,0,6,3,-0.740628166160081,0.768707482993197,0.0326552131061561,-0.216027280477408,0.764044943820225,0.673684210526316,-0.871499176276771,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.124,-1.028,"9:9","147/150","C:D:T:G",1.66318697401976,3.35314758209503e-05,0.400956055116994,4.14805301676878,2.39021356042842,11.7435962131774,0.722312927852139,6.93631068428177e-05,4.15887146261268,2.21601547098056,12.6651520546836,1.22263744860911e-05,"lineage4","dr_mutations_pyrazinamide","ALA",0,"ERR2706937","ERR2706937","lineage4.3.2","cd","Democratic Republic of Congo","pnca_p.asp12ala","A","G","ASP","DA12","pnca_complex.pdb"
|
|
"D12A","L2","PZA","D","D12",12,"A",0,"MDR","DM","hydrophilic","hydrophobic","acidic","non-polar","neg","non-polar",7.825,-2.924,0.904,0.896575,-1.267,1.36,64,80,-1.058,9,9,22,0.113989637305699,"helix",-1.4,5.01,0.0017967514733362,5.2760989010989,5.27609886875925,5.2752786493537,19.1276037177328,14,16,0,0,16,0,0,0,0,4,0,4,0,0,0,0,0,0,0,0,0,4,0,6,3,-0.740628166160081,0.768707482993197,0.0326552131061561,-0.216027280477408,0.764044943820225,0.673684210526316,-0.871499176276771,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.124,-1.028,"9:9","147/150","C:D:T:G",1.66318697401976,3.35314758209503e-05,0.400956055116994,4.14805301676878,2.39021356042842,11.7435962131774,0.722312927852139,6.93631068428177e-05,4.15887146261268,2.21601547098056,12.6651520546836,1.22263744860911e-05,"lineage2","dr_mutations_pyrazinamide","ALA",0,"ERR2516963","ERR2516963","lineage2.2.1","gb","UK","pnca_p.asp12ala","A","G","ASP","DA12","pnca_complex.pdb"
|
|
"D12A","L2","PZA","D","D12",12,"A",0,"MDR","DM","hydrophilic","hydrophobic","acidic","non-polar","neg","non-polar",7.825,-2.924,0.904,0.896575,-1.267,1.36,64,80,-1.058,9,9,22,0.113989637305699,"helix",-1.4,5.01,0.0017967514733362,5.2760989010989,5.27609886875925,5.2752786493537,19.1276037177328,14,16,0,0,16,0,0,0,0,4,0,4,0,0,0,0,0,0,0,0,0,4,0,6,3,-0.740628166160081,0.768707482993197,0.0326552131061561,-0.216027280477408,0.764044943820225,0.673684210526316,-0.871499176276771,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.124,-1.028,"9:9","147/150","C:D:T:G",1.66318697401976,3.35314758209503e-05,0.400956055116994,4.14805301676878,2.39021356042842,11.7435962131774,0.722312927852139,6.93631068428177e-05,4.15887146261268,2.21601547098056,12.6651520546836,1.22263744860911e-05,"lineage2","dr_mutations_pyrazinamide","ALA",0,"ERR2516795","ERR2516795","lineage2.2.1","gb","UK","pnca_p.asp12ala","A","G","ASP","DA12","pnca_complex.pdb"
|
|
"D12A","L2","PZA","D","D12",12,"A",NA,"MDR","DM","hydrophilic","hydrophobic","acidic","non-polar","neg","non-polar",7.825,-2.924,0.904,0.896575,-1.267,1.36,64,80,-1.058,9,9,22,0.113989637305699,"helix",-1.4,5.01,0.0017967514733362,5.2760989010989,5.27609886875925,5.2752786493537,19.1276037177328,14,16,0,0,16,0,0,0,0,4,0,4,0,0,0,0,0,0,0,0,0,4,0,6,3,-0.740628166160081,0.768707482993197,0.0326552131061561,-0.216027280477408,0.764044943820225,0.673684210526316,-0.871499176276771,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.124,-1.028,"9:9","147/150","C:D:T:G",1.66318697401976,3.35314758209503e-05,0.400956055116994,4.14805301676878,2.39021356042842,11.7435962131774,0.722312927852139,6.93631068428177e-05,4.15887146261268,2.21601547098056,12.6651520546836,1.22263744860911e-05,"lineage2","dr_mutations_pyrazinamide","ALA",0,"ERR067749","ERR067749","lineage2.2.1","ru","Russia","pnca_p.asp12ala","A","G","ASP","DA12","pnca_complex.pdb"
|
|
"D12A","L2","PZA","D","D12",12,"A",NA,"Pre-MDR","DM","hydrophilic","hydrophobic","acidic","non-polar","neg","non-polar",7.825,-2.924,0.904,0.896575,-1.267,1.36,64,80,-1.058,9,9,22,0.113989637305699,"helix",-1.4,5.01,0.0017967514733362,5.2760989010989,5.27609886875925,5.2752786493537,19.1276037177328,14,16,0,0,16,0,0,0,0,4,0,4,0,0,0,0,0,0,0,0,0,4,0,6,3,-0.740628166160081,0.768707482993197,0.0326552131061561,-0.216027280477408,0.764044943820225,0.673684210526316,-0.871499176276771,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.124,-1.028,"9:9","147/150","C:D:T:G",1.66318697401976,3.35314758209503e-05,0.400956055116994,4.14805301676878,2.39021356042842,11.7435962131774,0.722312927852139,6.93631068428177e-05,4.15887146261268,2.21601547098056,12.6651520546836,1.22263744860911e-05,"lineage2","dr_mutations_pyrazinamide","ALA",0,"SRS796956","SRR1723441","lineage2.2.1","cn","China:Guangxi","pnca_p.asp12ala","A","G","ASP","DA12","pnca_complex.pdb"
|
|
"D12A","L4","PZA","D","D12",12,"A",NA,"MDR","DM","hydrophilic","hydrophobic","acidic","non-polar","neg","non-polar",7.825,-2.924,0.904,0.896575,-1.267,1.36,64,80,-1.058,9,9,22,0.113989637305699,"helix",-1.4,5.01,0.0017967514733362,5.2760989010989,5.27609886875925,5.2752786493537,19.1276037177328,14,16,0,0,16,0,0,0,0,4,0,4,0,0,0,0,0,0,0,0,0,4,0,6,3,-0.740628166160081,0.768707482993197,0.0326552131061561,-0.216027280477408,0.764044943820225,0.673684210526316,-0.871499176276771,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.124,-1.028,"9:9","147/150","C:D:T:G",1.66318697401976,3.35314758209503e-05,0.400956055116994,4.14805301676878,2.39021356042842,11.7435962131774,0.722312927852139,6.93631068428177e-05,4.15887146261268,2.21601547098056,12.6651520546836,1.22263744860911e-05,"lineage4","dr_mutations_pyrazinamide","ALA",0,"ERR1034726","ERR1034726","lineage4.3.4.1","pe","Peru","pnca_p.asp12ala","A","G","ASP","DA12","pnca_complex.pdb"
|
|
"D12A","L4","PZA","D","D12",12,"A",1,"MDR","DM","hydrophilic","hydrophobic","acidic","non-polar","neg","non-polar",7.825,-2.924,0.904,0.896575,-1.267,1.36,64,80,-1.058,9,9,22,0.113989637305699,"helix",-1.4,5.01,0.0017967514733362,5.2760989010989,5.27609886875925,5.2752786493537,19.1276037177328,14,16,0,0,16,0,0,0,0,4,0,4,0,0,0,0,0,0,0,0,0,4,0,6,3,-0.740628166160081,0.768707482993197,0.0326552131061561,-0.216027280477408,0.764044943820225,0.673684210526316,-0.871499176276771,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.124,-1.028,"9:9","147/150","C:D:T:G",1.66318697401976,3.35314758209503e-05,0.400956055116994,4.14805301676878,2.39021356042842,11.7435962131774,0.722312927852139,6.93631068428177e-05,4.15887146261268,2.21601547098056,12.6651520546836,1.22263744860911e-05,"lineage4","dr_mutations_pyrazinamide","ALA",0,"ERR1034725","ERR1034725","lineage4.3.4.1","pe","Peru","pnca_p.asp12ala","A","G","ASP","DA12","pnca_complex.pdb"
|
|
"D12A","L2","PZA","D","D12",12,"A",1,"MDR","DM","hydrophilic","hydrophobic","acidic","non-polar","neg","non-polar",7.825,-2.924,0.904,0.896575,-1.267,1.36,64,80,-1.058,9,9,22,0.113989637305699,"helix",-1.4,5.01,0.0017967514733362,5.2760989010989,5.27609886875925,5.2752786493537,19.1276037177328,14,16,0,0,16,0,0,0,0,4,0,4,0,0,0,0,0,0,0,0,0,4,0,6,3,-0.740628166160081,0.768707482993197,0.0326552131061561,-0.216027280477408,0.764044943820225,0.673684210526316,-0.871499176276771,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.124,-1.028,"9:9","147/150","C:D:T:G",1.66318697401976,3.35314758209503e-05,0.400956055116994,4.14805301676878,2.39021356042842,11.7435962131774,0.722312927852139,6.93631068428177e-05,4.15887146261268,2.21601547098056,12.6651520546836,1.22263744860911e-05,"lineage2","dr_mutations_pyrazinamide","ALA",0,"ERS2286329","ERR2503403","lineage2.2.1","fi","Finland","pnca_p.asp12ala","A","G","ASP","DA12","pnca_complex.pdb"
|
|
"D12A","L4","PZA","D","D12",12,"A",1,"MDR","DM","hydrophilic","hydrophobic","acidic","non-polar","neg","non-polar",7.825,-2.924,0.904,0.896575,-1.267,1.36,64,80,-1.058,9,9,22,0.113989637305699,"helix",-1.4,5.01,0.0017967514733362,5.2760989010989,5.27609886875925,5.2752786493537,19.1276037177328,14,16,0,0,16,0,0,0,0,4,0,4,0,0,0,0,0,0,0,0,0,4,0,6,3,-0.740628166160081,0.768707482993197,0.0326552131061561,-0.216027280477408,0.764044943820225,0.673684210526316,-0.871499176276771,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.124,-1.028,"9:9","147/150","C:D:T:G",1.66318697401976,3.35314758209503e-05,0.400956055116994,4.14805301676878,2.39021356042842,11.7435962131774,0.722312927852139,6.93631068428177e-05,4.15887146261268,2.21601547098056,12.6651520546836,1.22263744860911e-05,"lineage4","dr_mutations_pyrazinamide","ALA",0,"MDR_5134","SRR6824531","lineage4.5","cn","China: Huimin District, Huhhot City, Inner Mongolia Province","pnca_p.asp12ala","A","G","ASP","DA12","pnca_complex.pdb"
|
|
"D12A","L4","PZA","D","D12",12,"A",NA,"Pre-XDR","DM","hydrophilic","hydrophobic","acidic","non-polar","neg","non-polar",7.825,-2.924,0.904,0.896575,-1.267,1.36,64,80,-1.058,9,9,22,0.113989637305699,"helix",-1.4,5.01,0.0017967514733362,5.2760989010989,5.27609886875925,5.2752786493537,19.1276037177328,14,16,0,0,16,0,0,0,0,4,0,4,0,0,0,0,0,0,0,0,0,4,0,6,3,-0.740628166160081,0.768707482993197,0.0326552131061561,-0.216027280477408,0.764044943820225,0.673684210526316,-0.871499176276771,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.124,-1.028,"9:9","147/150","C:D:T:G",1.66318697401976,3.35314758209503e-05,0.400956055116994,4.14805301676878,2.39021356042842,11.7435962131774,0.722312927852139,6.93631068428177e-05,4.15887146261268,2.21601547098056,12.6651520546836,1.22263744860911e-05,"lineage4","dr_mutations_pyrazinamide","ALA",0,"SAMN02584640","SRR1169083_SRR1166300","lineage4.2.1","md","Moldova","pnca_p.asp12ala","A","G","ASP","DA12","pnca_complex.pdb"
|
|
"D12A","L4","PZA","D","D12",12,"A",1,"XDR","DM","hydrophilic","hydrophobic","acidic","non-polar","neg","non-polar",7.825,-2.924,0.904,0.896575,-1.267,1.36,64,80,-1.058,9,9,22,0.113989637305699,"helix",-1.4,5.01,0.0017967514733362,5.2760989010989,5.27609886875925,5.2752786493537,19.1276037177328,14,16,0,0,16,0,0,0,0,4,0,4,0,0,0,0,0,0,0,0,0,4,0,6,3,-0.740628166160081,0.768707482993197,0.0326552131061561,-0.216027280477408,0.764044943820225,0.673684210526316,-0.871499176276771,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.124,-1.028,"9:9","147/150","C:D:T:G",1.66318697401976,3.35314758209503e-05,0.400956055116994,4.14805301676878,2.39021356042842,11.7435962131774,0.722312927852139,6.93631068428177e-05,4.15887146261268,2.21601547098056,12.6651520546836,1.22263744860911e-05,"lineage4","dr_mutations_pyrazinamide","ALA",0,"ERR2510711","ERR2510711","lineage4.2.1","it","Italy","pnca_p.asp12ala","A","G","ASP","DA12","pnca_complex.pdb"
|
|
"D12A","L4","PZA","D","D12",12,"A",NA,"MDR","DM","hydrophilic","hydrophobic","acidic","non-polar","neg","non-polar",7.825,-2.924,0.904,0.896575,-1.267,1.36,64,80,-1.058,9,9,22,0.113989637305699,"helix",-1.4,5.01,0.0017967514733362,5.2760989010989,5.27609886875925,5.2752786493537,19.1276037177328,14,16,0,0,16,0,0,0,0,4,0,4,0,0,0,0,0,0,0,0,0,4,0,6,3,-0.740628166160081,0.768707482993197,0.0326552131061561,-0.216027280477408,0.764044943820225,0.673684210526316,-0.871499176276771,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.124,-1.028,"9:9","147/150","C:D:T:G",1.66318697401976,3.35314758209503e-05,0.400956055116994,4.14805301676878,2.39021356042842,11.7435962131774,0.722312927852139,6.93631068428177e-05,4.15887146261268,2.21601547098056,12.6651520546836,1.22263744860911e-05,"lineage4","dr_mutations_pyrazinamide","ALA",0,"ERR2707034","ERR2707034","lineage4.3.2","cd","Democratic Republic of Congo","pnca_p.asp12ala","A","G","ASP","DA12","pnca_complex.pdb"
|
|
"D12A","L4","PZA","D","D12",12,"A",NA,"Pre-XDR","DM","hydrophilic","hydrophobic","acidic","non-polar","neg","non-polar",7.825,-2.924,0.904,0.896575,-1.267,1.36,64,80,-1.058,9,9,22,0.113989637305699,"helix",-1.4,5.01,0.0017967514733362,5.2760989010989,5.27609886875925,5.2752786493537,19.1276037177328,14,16,0,0,16,0,0,0,0,4,0,4,0,0,0,0,0,0,0,0,0,4,0,6,3,-0.740628166160081,0.768707482993197,0.0326552131061561,-0.216027280477408,0.764044943820225,0.673684210526316,-0.871499176276771,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.124,-1.028,"9:9","147/150","C:D:T:G",1.66318697401976,3.35314758209503e-05,0.400956055116994,4.14805301676878,2.39021356042842,11.7435962131774,0.722312927852139,6.93631068428177e-05,4.15887146261268,2.21601547098056,12.6651520546836,1.22263744860911e-05,"lineage4","dr_mutations_pyrazinamide","ALA",0,"SAMN02584589","SRR1169011_SRR1166315","lineage4.2.1","md","Moldova","pnca_p.asp12ala","A","G","ASP","DA12","pnca_complex.pdb"
|
|
"D12A","L4","PZA","D","D12",12,"A",1,"MDR","DM","hydrophilic","hydrophobic","acidic","non-polar","neg","non-polar",7.825,-2.924,0.904,0.896575,-1.267,1.36,64,80,-1.058,9,9,22,0.113989637305699,"helix",-1.4,5.01,0.0017967514733362,5.2760989010989,5.27609886875925,5.2752786493537,19.1276037177328,14,16,0,0,16,0,0,0,0,4,0,4,0,0,0,0,0,0,0,0,0,4,0,6,3,-0.740628166160081,0.768707482993197,0.0326552131061561,-0.216027280477408,0.764044943820225,0.673684210526316,-0.871499176276771,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.124,-1.028,"9:9","147/150","C:D:T:G",1.66318697401976,3.35314758209503e-05,0.400956055116994,4.14805301676878,2.39021356042842,11.7435962131774,0.722312927852139,6.93631068428177e-05,4.15887146261268,2.21601547098056,12.6651520546836,1.22263744860911e-05,"lineage4","dr_mutations_pyrazinamide","ALA",0,"ERR038748","ERR038748","lineage4.6.1.2","ug","Uganda","pnca_p.asp12ala","A","G","ASP","DA12","pnca_complex.pdb"
|
|
"D12A","L2","PZA","D","D12",12,"A",NA,"Pre-XDR","DM","hydrophilic","hydrophobic","acidic","non-polar","neg","non-polar",7.825,-2.924,0.904,0.896575,-1.267,1.36,64,80,-1.058,9,9,22,0.113989637305699,"helix",-1.4,5.01,0.0017967514733362,5.2760989010989,5.27609886875925,5.2752786493537,19.1276037177328,14,16,0,0,16,0,0,0,0,4,0,4,0,0,0,0,0,0,0,0,0,4,0,6,3,-0.740628166160081,0.768707482993197,0.0326552131061561,-0.216027280477408,0.764044943820225,0.673684210526316,-0.871499176276771,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.124,-1.028,"9:9","147/150","C:D:T:G",1.66318697401976,3.35314758209503e-05,0.400956055116994,4.14805301676878,2.39021356042842,11.7435962131774,0.722312927852139,6.93631068428177e-05,4.15887146261268,2.21601547098056,12.6651520546836,1.22263744860911e-05,"lineage2","dr_mutations_pyrazinamide","ALA",0,"SRR5709794,SAMN07236265","SRR5709794","lineage2.2.1","th","Thailand","pnca_p.asp12ala","A","G","ASP","DA12","pnca_complex.pdb"
|
|
"D12A","L4","PZA","D","D12",12,"A",NA,"MDR","DM","hydrophilic","hydrophobic","acidic","non-polar","neg","non-polar",7.825,-2.924,0.904,0.896575,-1.267,1.36,64,80,-1.058,9,9,22,0.113989637305699,"helix",-1.4,5.01,0.0017967514733362,5.2760989010989,5.27609886875925,5.2752786493537,19.1276037177328,14,16,0,0,16,0,0,0,0,4,0,4,0,0,0,0,0,0,0,0,0,4,0,6,3,-0.740628166160081,0.768707482993197,0.0326552131061561,-0.216027280477408,0.764044943820225,0.673684210526316,-0.871499176276771,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.124,-1.028,"9:9","147/150","C:D:T:G",1.66318697401976,3.35314758209503e-05,0.400956055116994,4.14805301676878,2.39021356042842,11.7435962131774,0.722312927852139,6.93631068428177e-05,4.15887146261268,2.21601547098056,12.6651520546836,1.22263744860911e-05,"lineage4","dr_mutations_pyrazinamide","ALA",0,"SAMN02380998","SRR1062888_SRR1049599_SRR1049600_SRR1140717","lineage4.6.1.2","ug","Uganda","pnca_p.asp12ala","A","G","ASP","DA12","pnca_complex.pdb"
|
|
"D12A","L2","PZA","D","D12",12,"A",1,"MDR","DM","hydrophilic","hydrophobic","acidic","non-polar","neg","non-polar",7.825,-2.924,0.904,0.896575,-1.267,1.36,64,80,-1.058,9,9,22,0.113989637305699,"helix",-1.4,5.01,0.0017967514733362,5.2760989010989,5.27609886875925,5.2752786493537,19.1276037177328,14,16,0,0,16,0,0,0,0,4,0,4,0,0,0,0,0,0,0,0,0,4,0,6,3,-0.740628166160081,0.768707482993197,0.0326552131061561,-0.216027280477408,0.764044943820225,0.673684210526316,-0.871499176276771,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.124,-1.028,"9:9","147/150","C:D:T:G",1.66318697401976,3.35314758209503e-05,0.400956055116994,4.14805301676878,2.39021356042842,11.7435962131774,0.722312927852139,6.93631068428177e-05,4.15887146261268,2.21601547098056,12.6651520546836,1.22263744860911e-05,"lineage2","dr_mutations_pyrazinamide","ALA",0,"MDR_5166","SRR6824476","lineage2.2.1","cn","China: Huimin District, Huhhot City, Inner Mongolia Province","pnca_p.asp12ala","A","G","ASP","DA12","pnca_complex.pdb"
|
|
"D12A","L4","PZA","D","D12",12,"A",NA,"MDR","DM","hydrophilic","hydrophobic","acidic","non-polar","neg","non-polar",7.825,-2.924,0.904,0.896575,-1.267,1.36,64,80,-1.058,9,9,22,0.113989637305699,"helix",-1.4,5.01,0.0017967514733362,5.2760989010989,5.27609886875925,5.2752786493537,19.1276037177328,14,16,0,0,16,0,0,0,0,4,0,4,0,0,0,0,0,0,0,0,0,4,0,6,3,-0.740628166160081,0.768707482993197,0.0326552131061561,-0.216027280477408,0.764044943820225,0.673684210526316,-0.871499176276771,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.124,-1.028,"9:9","147/150","C:D:T:G",1.66318697401976,3.35314758209503e-05,0.400956055116994,4.14805301676878,2.39021356042842,11.7435962131774,0.722312927852139,6.93631068428177e-05,4.15887146261268,2.21601547098056,12.6651520546836,1.22263744860911e-05,"lineage4","dr_mutations_pyrazinamide","ALA",0,"SAMN02414927","SRR1146355_SRR1144781_SRR1162895_SRR1163206","lineage4.6.1.2","se","Sweden","pnca_p.asp12ala","A","G","ASP","DA12","pnca_complex.pdb"
|
|
"D12A","L4","PZA","D","D12",12,"A",1,"Pre-XDR","DM","hydrophilic","hydrophobic","acidic","non-polar","neg","non-polar",7.825,-2.924,0.904,0.896575,-1.267,1.36,64,80,-1.058,9,9,22,0.113989637305699,"helix",-1.4,5.01,0.0017967514733362,5.2760989010989,5.27609886875925,5.2752786493537,19.1276037177328,14,16,0,0,16,0,0,0,0,4,0,4,0,0,0,0,0,0,0,0,0,4,0,6,3,-0.740628166160081,0.768707482993197,0.0326552131061561,-0.216027280477408,0.764044943820225,0.673684210526316,-0.871499176276771,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.124,-1.028,"9:9","147/150","C:D:T:G",1.66318697401976,3.35314758209503e-05,0.400956055116994,4.14805301676878,2.39021356042842,11.7435962131774,0.722312927852139,6.93631068428177e-05,4.15887146261268,2.21601547098056,12.6651520546836,1.22263744860911e-05,"lineage4","dr_mutations_pyrazinamide","ALA",0,"ERR2516647","ERR2516647","lineage4.3.4.1","pe","Peru","pnca_p.asp12ala","A","G","ASP","DA12","pnca_complex.pdb"
|
|
"D12A","L4","PZA","D","D12",12,"A",NA,"MDR","DM","hydrophilic","hydrophobic","acidic","non-polar","neg","non-polar",7.825,-2.924,0.904,0.896575,-1.267,1.36,64,80,-1.058,9,9,22,0.113989637305699,"helix",-1.4,5.01,0.0017967514733362,5.2760989010989,5.27609886875925,5.2752786493537,19.1276037177328,14,16,0,0,16,0,0,0,0,4,0,4,0,0,0,0,0,0,0,0,0,4,0,6,3,-0.740628166160081,0.768707482993197,0.0326552131061561,-0.216027280477408,0.764044943820225,0.673684210526316,-0.871499176276771,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.124,-1.028,"9:9","147/150","C:D:T:G",1.66318697401976,3.35314758209503e-05,0.400956055116994,4.14805301676878,2.39021356042842,11.7435962131774,0.722312927852139,6.93631068428177e-05,4.15887146261268,2.21601547098056,12.6651520546836,1.22263744860911e-05,"lineage4","dr_mutations_pyrazinamide","ALA",0,"ERR2707140","ERR2707140","lineage4.3.2","cd","Democratic Republic of Congo","pnca_p.asp12ala","A","G","ASP","DA12","pnca_complex.pdb"
|
|
"D12A","L4","PZA","D","D12",12,"A",NA,"MDR","DM","hydrophilic","hydrophobic","acidic","non-polar","neg","non-polar",7.825,-2.924,0.904,0.896575,-1.267,1.36,64,80,-1.058,9,9,22,0.113989637305699,"helix",-1.4,5.01,0.0017967514733362,5.2760989010989,5.27609886875925,5.2752786493537,19.1276037177328,14,16,0,0,16,0,0,0,0,4,0,4,0,0,0,0,0,0,0,0,0,4,0,6,3,-0.740628166160081,0.768707482993197,0.0326552131061561,-0.216027280477408,0.764044943820225,0.673684210526316,-0.871499176276771,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.124,-1.028,"9:9","147/150","C:D:T:G",1.66318697401976,3.35314758209503e-05,0.400956055116994,4.14805301676878,2.39021356042842,11.7435962131774,0.722312927852139,6.93631068428177e-05,4.15887146261268,2.21601547098056,12.6651520546836,1.22263744860911e-05,"lineage4","dr_mutations_pyrazinamide","ALA",0,"ERR775388","ERR775388","lineage4.3.3","pe","","pnca_p.asp12ala","A","G","ASP","DA12","pnca_complex.pdb"
|
|
"D12A","L4","PZA","D","D12",12,"A",NA,"MDR","DM","hydrophilic","hydrophobic","acidic","non-polar","neg","non-polar",7.825,-2.924,0.904,0.896575,-1.267,1.36,64,80,-1.058,9,9,22,0.113989637305699,"helix",-1.4,5.01,0.0017967514733362,5.2760989010989,5.27609886875925,5.2752786493537,19.1276037177328,14,16,0,0,16,0,0,0,0,4,0,4,0,0,0,0,0,0,0,0,0,4,0,6,3,-0.740628166160081,0.768707482993197,0.0326552131061561,-0.216027280477408,0.764044943820225,0.673684210526316,-0.871499176276771,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.124,-1.028,"9:9","147/150","C:D:T:G",1.66318697401976,3.35314758209503e-05,0.400956055116994,4.14805301676878,2.39021356042842,11.7435962131774,0.722312927852139,6.93631068428177e-05,4.15887146261268,2.21601547098056,12.6651520546836,1.22263744860911e-05,"lineage4","dr_mutations_pyrazinamide","ALA",0,"ERR2707224","ERR2707224","lineage4.6.1.2","cd","Democratic Republic of Congo","pnca_p.asp12ala","A","G","ASP","DA12","pnca_complex.pdb"
|
|
"D12A","L2","PZA","D","D12",12,"A",0,"Pre-MDR","DM","hydrophilic","hydrophobic","acidic","non-polar","neg","non-polar",7.825,-2.924,0.904,0.896575,-1.267,1.36,64,80,-1.058,9,9,22,0.113989637305699,"helix",-1.4,5.01,0.0017967514733362,5.2760989010989,5.27609886875925,5.2752786493537,19.1276037177328,14,16,0,0,16,0,0,0,0,4,0,4,0,0,0,0,0,0,0,0,0,4,0,6,3,-0.740628166160081,0.768707482993197,0.0326552131061561,-0.216027280477408,0.764044943820225,0.673684210526316,-0.871499176276771,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.124,-1.028,"9:9","147/150","C:D:T:G",1.66318697401976,3.35314758209503e-05,0.400956055116994,4.14805301676878,2.39021356042842,11.7435962131774,0.722312927852139,6.93631068428177e-05,4.15887146261268,2.21601547098056,12.6651520546836,1.22263744860911e-05,"lineage2","dr_mutations_pyrazinamide","ALA",0,"MDR_20163","SRR6824291","lineage2.2.1","cn","China: Pinguo County, Baise City, Guangxi Province","pnca_p.asp12ala","A","G","ASP","DA12","pnca_complex.pdb"
|
|
"D12A","L4","PZA","D","D12",12,"A",NA,"MDR","DM","hydrophilic","hydrophobic","acidic","non-polar","neg","non-polar",7.825,-2.924,0.904,0.896575,-1.267,1.36,64,80,-1.058,9,9,22,0.113989637305699,"helix",-1.4,5.01,0.0017967514733362,5.2760989010989,5.27609886875925,5.2752786493537,19.1276037177328,14,16,0,0,16,0,0,0,0,4,0,4,0,0,0,0,0,0,0,0,0,4,0,6,3,-0.740628166160081,0.768707482993197,0.0326552131061561,-0.216027280477408,0.764044943820225,0.673684210526316,-0.871499176276771,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.124,-1.028,"9:9","147/150","C:D:T:G",1.66318697401976,3.35314758209503e-05,0.400956055116994,4.14805301676878,2.39021356042842,11.7435962131774,0.722312927852139,6.93631068428177e-05,4.15887146261268,2.21601547098056,12.6651520546836,1.22263744860911e-05,"lineage4","dr_mutations_pyrazinamide","ALA",0,"ERR1023411","ERR1023411","lineage4.6.1.2","","","pnca_p.asp12ala","A","G","ASP","DA12","pnca_complex.pdb"
|
|
"D12A","L4","PZA","D","D12",12,"A",NA,"MDR","DM","hydrophilic","hydrophobic","acidic","non-polar","neg","non-polar",7.825,-2.924,0.904,0.896575,-1.267,1.36,64,80,-1.058,9,9,22,0.113989637305699,"helix",-1.4,5.01,0.0017967514733362,5.2760989010989,5.27609886875925,5.2752786493537,19.1276037177328,14,16,0,0,16,0,0,0,0,4,0,4,0,0,0,0,0,0,0,0,0,4,0,6,3,-0.740628166160081,0.768707482993197,0.0326552131061561,-0.216027280477408,0.764044943820225,0.673684210526316,-0.871499176276771,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.124,-1.028,"9:9","147/150","C:D:T:G",1.66318697401976,3.35314758209503e-05,0.400956055116994,4.14805301676878,2.39021356042842,11.7435962131774,0.722312927852139,6.93631068428177e-05,4.15887146261268,2.21601547098056,12.6651520546836,1.22263744860911e-05,"lineage4","dr_mutations_pyrazinamide","ALA",0,"ERR845935","ERR845935","lineage4.3.4.1","pe","","pnca_p.asp12ala","A","G","ASP","DA12","pnca_complex.pdb"
|
|
"D12A","L4","PZA","D","D12",12,"A",NA,"MDR","DM","hydrophilic","hydrophobic","acidic","non-polar","neg","non-polar",7.825,-2.924,0.904,0.896575,-1.267,1.36,64,80,-1.058,9,9,22,0.113989637305699,"helix",-1.4,5.01,0.0017967514733362,5.2760989010989,5.27609886875925,5.2752786493537,19.1276037177328,14,16,0,0,16,0,0,0,0,4,0,4,0,0,0,0,0,0,0,0,0,4,0,6,3,-0.740628166160081,0.768707482993197,0.0326552131061561,-0.216027280477408,0.764044943820225,0.673684210526316,-0.871499176276771,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.124,-1.028,"9:9","147/150","C:D:T:G",1.66318697401976,3.35314758209503e-05,0.400956055116994,4.14805301676878,2.39021356042842,11.7435962131774,0.722312927852139,6.93631068428177e-05,4.15887146261268,2.21601547098056,12.6651520546836,1.22263744860911e-05,"lineage4","dr_mutations_pyrazinamide","ALA",0,"SRS797366","SRR1723900","lineage4.5","cn","China:InnerMongolia","pnca_p.asp12ala","A","G","ASP","DA12","pnca_complex.pdb"
|
|
"D12A","L1","PZA","D","D12",12,"A",NA,"Pre-MDR","DM","hydrophilic","hydrophobic","acidic","non-polar","neg","non-polar",7.825,-2.924,0.904,0.896575,-1.267,1.36,64,80,-1.058,9,9,22,0.113989637305699,"helix",-1.4,5.01,0.0017967514733362,5.2760989010989,5.27609886875925,5.2752786493537,19.1276037177328,14,16,0,0,16,0,0,0,0,4,0,4,0,0,0,0,0,0,0,0,0,4,0,6,3,-0.740628166160081,0.768707482993197,0.0326552131061561,-0.216027280477408,0.764044943820225,0.673684210526316,-0.871499176276771,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.124,-1.028,"9:9","147/150","C:D:T:G",1.66318697401976,3.35314758209503e-05,0.400956055116994,4.14805301676878,2.39021356042842,11.7435962131774,0.722312927852139,6.93631068428177e-05,4.15887146261268,2.21601547098056,12.6651520546836,1.22263744860911e-05,"lineage1","dr_mutations_pyrazinamide","ALA",0,"ERR3256152","ERR3256152","lineage1.2.1","ph","Philippines","pnca_p.asp12ala","A","G","ASP","DA12","pnca_complex.pdb"
|
|
"D12A","L2","PZA","D","D12",12,"A",0,"MDR","DM","hydrophilic","hydrophobic","acidic","non-polar","neg","non-polar",7.825,-2.924,0.904,0.896575,-1.267,1.36,64,80,-1.058,9,9,22,0.113989637305699,"helix",-1.4,5.01,0.0017967514733362,5.2760989010989,5.27609886875925,5.2752786493537,19.1276037177328,14,16,0,0,16,0,0,0,0,4,0,4,0,0,0,0,0,0,0,0,0,4,0,6,3,-0.740628166160081,0.768707482993197,0.0326552131061561,-0.216027280477408,0.764044943820225,0.673684210526316,-0.871499176276771,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.124,-1.028,"9:9","147/150","C:D:T:G",1.66318697401976,3.35314758209503e-05,0.400956055116994,4.14805301676878,2.39021356042842,11.7435962131774,0.722312927852139,6.93631068428177e-05,4.15887146261268,2.21601547098056,12.6651520546836,1.22263744860911e-05,"lineage2","dr_mutations_pyrazinamide","ALA",0,"ERR2517117","ERR2517117","lineage2.2.1","gb","UK","pnca_p.asp12ala","A","G","ASP","DA12","pnca_complex.pdb"
|
|
"D12A","L2","PZA","D","D12",12,"A",0,"MDR","DM","hydrophilic","hydrophobic","acidic","non-polar","neg","non-polar",7.825,-2.924,0.904,0.896575,-1.267,1.36,64,80,-1.058,9,9,22,0.113989637305699,"helix",-1.4,5.01,0.0017967514733362,5.2760989010989,5.27609886875925,5.2752786493537,19.1276037177328,14,16,0,0,16,0,0,0,0,4,0,4,0,0,0,0,0,0,0,0,0,4,0,6,3,-0.740628166160081,0.768707482993197,0.0326552131061561,-0.216027280477408,0.764044943820225,0.673684210526316,-0.871499176276771,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.124,-1.028,"9:9","147/150","C:D:T:G",1.66318697401976,3.35314758209503e-05,0.400956055116994,4.14805301676878,2.39021356042842,11.7435962131774,0.722312927852139,6.93631068428177e-05,4.15887146261268,2.21601547098056,12.6651520546836,1.22263744860911e-05,"lineage2","dr_mutations_pyrazinamide","ALA",0,"ERR2516888","ERR2516888","lineage2.2.1","gb","UK","pnca_p.asp12ala","A","G","ASP","DA12","pnca_complex.pdb"
|
|
"D12A","L2","PZA","D","D12",12,"A",0,"XDR","DM","hydrophilic","hydrophobic","acidic","non-polar","neg","non-polar",7.825,-2.924,0.904,0.896575,-1.267,1.36,64,80,-1.058,9,9,22,0.113989637305699,"helix",-1.4,5.01,0.0017967514733362,5.2760989010989,5.27609886875925,5.2752786493537,19.1276037177328,14,16,0,0,16,0,0,0,0,4,0,4,0,0,0,0,0,0,0,0,0,4,0,6,3,-0.740628166160081,0.768707482993197,0.0326552131061561,-0.216027280477408,0.764044943820225,0.673684210526316,-0.871499176276771,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.124,-1.028,"9:9","147/150","C:D:T:G",1.66318697401976,3.35314758209503e-05,0.400956055116994,4.14805301676878,2.39021356042842,11.7435962131774,0.722312927852139,6.93631068428177e-05,4.15887146261268,2.21601547098056,12.6651520546836,1.22263744860911e-05,"lineage2","dr_mutations_pyrazinamide","ALA",0,"ERR2516943","ERR2516943","lineage2.2.1","gb","UK","pnca_p.asp12ala","A","G","ASP","DA12","pnca_complex.pdb"
|
|
"D12A","L2","PZA","D","D12",12,"A",NA,"Pre-MDR","DM","hydrophilic","hydrophobic","acidic","non-polar","neg","non-polar",7.825,-2.924,0.904,0.896575,-1.267,1.36,64,80,-1.058,9,9,22,0.113989637305699,"helix",-1.4,5.01,0.0017967514733362,5.2760989010989,5.27609886875925,5.2752786493537,19.1276037177328,14,16,0,0,16,0,0,0,0,4,0,4,0,0,0,0,0,0,0,0,0,4,0,6,3,-0.740628166160081,0.768707482993197,0.0326552131061561,-0.216027280477408,0.764044943820225,0.673684210526316,-0.871499176276771,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.124,-1.028,"9:9","147/150","C:D:T:G",1.66318697401976,3.35314758209503e-05,0.400956055116994,4.14805301676878,2.39021356042842,11.7435962131774,0.722312927852139,6.93631068428177e-05,4.15887146261268,2.21601547098056,12.6651520546836,1.22263744860911e-05,"lineage2","dr_mutations_pyrazinamide","ALA",0,"BGI_C-xz06202,SRR671728","SRR671728","lineage2.2.1","cn","China","pnca_p.asp12ala","A","G","ASP","DA12","pnca_complex.pdb"
|
|
"D12A","L2","PZA","D","D12",12,"A",NA,"Pre-MDR","DM","hydrophilic","hydrophobic","acidic","non-polar","neg","non-polar",7.825,-2.924,0.904,0.896575,-1.267,1.36,64,80,-1.058,9,9,22,0.113989637305699,"helix",-1.4,5.01,0.0017967514733362,5.2760989010989,5.27609886875925,5.2752786493537,19.1276037177328,14,16,0,0,16,0,0,0,0,4,0,4,0,0,0,0,0,0,0,0,0,4,0,6,3,-0.740628166160081,0.768707482993197,0.0326552131061561,-0.216027280477408,0.764044943820225,0.673684210526316,-0.871499176276771,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.124,-1.028,"9:9","147/150","C:D:T:G",1.66318697401976,3.35314758209503e-05,0.400956055116994,4.14805301676878,2.39021356042842,11.7435962131774,0.722312927852139,6.93631068428177e-05,4.15887146261268,2.21601547098056,12.6651520546836,1.22263744860911e-05,"lineage2","dr_mutations_pyrazinamide","ALA",0,"SRR5073984","SRR5073984","lineage2.2.1","vn","Vietnam","pnca_p.asp12ala","A","G","ASP","DA12","pnca_complex.pdb"
|
|
"D12A","L2","PZA","D","D12",12,"A",0,"MDR","DM","hydrophilic","hydrophobic","acidic","non-polar","neg","non-polar",7.825,-2.924,0.904,0.896575,-1.267,1.36,64,80,-1.058,9,9,22,0.113989637305699,"helix",-1.4,5.01,0.0017967514733362,5.2760989010989,5.27609886875925,5.2752786493537,19.1276037177328,14,16,0,0,16,0,0,0,0,4,0,4,0,0,0,0,0,0,0,0,0,4,0,6,3,-0.740628166160081,0.768707482993197,0.0326552131061561,-0.216027280477408,0.764044943820225,0.673684210526316,-0.871499176276771,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.124,-1.028,"9:9","147/150","C:D:T:G",1.66318697401976,3.35314758209503e-05,0.400956055116994,4.14805301676878,2.39021356042842,11.7435962131774,0.722312927852139,6.93631068428177e-05,4.15887146261268,2.21601547098056,12.6651520546836,1.22263744860911e-05,"lineage2","dr_mutations_pyrazinamide","ALA",0,"ERR552479","ERR552479","lineage2.2.1","kz","Kazakhstan","pnca_p.asp12ala","A","G","ASP","DA12","pnca_complex.pdb"
|
|
"D12A","L4","PZA","D","D12",12,"A",NA,"Pre-XDR","DM","hydrophilic","hydrophobic","acidic","non-polar","neg","non-polar",7.825,-2.924,0.904,0.896575,-1.267,1.36,64,80,-1.058,9,9,22,0.113989637305699,"helix",-1.4,5.01,0.0017967514733362,5.2760989010989,5.27609886875925,5.2752786493537,19.1276037177328,14,16,0,0,16,0,0,0,0,4,0,4,0,0,0,0,0,0,0,0,0,4,0,6,3,-0.740628166160081,0.768707482993197,0.0326552131061561,-0.216027280477408,0.764044943820225,0.673684210526316,-0.871499176276771,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.124,-1.028,"9:9","147/150","C:D:T:G",1.66318697401976,3.35314758209503e-05,0.400956055116994,4.14805301676878,2.39021356042842,11.7435962131774,0.722312927852139,6.93631068428177e-05,4.15887146261268,2.21601547098056,12.6651520546836,1.22263744860911e-05,"lineage4","dr_mutations_pyrazinamide","ALA",0,"SAMN02584611","SRR1166261_SRR1169165","lineage4.2.1","md","Moldova","pnca_p.asp12ala","A","G","ASP","DA12","pnca_complex.pdb"
|
|
"D12A","L4","PZA","D","D12",12,"A",NA,"MDR","DM","hydrophilic","hydrophobic","acidic","non-polar","neg","non-polar",7.825,-2.924,0.904,0.896575,-1.267,1.36,64,80,-1.058,9,9,22,0.113989637305699,"helix",-1.4,5.01,0.0017967514733362,5.2760989010989,5.27609886875925,5.2752786493537,19.1276037177328,14,16,0,0,16,0,0,0,0,4,0,4,0,0,0,0,0,0,0,0,0,4,0,6,3,-0.740628166160081,0.768707482993197,0.0326552131061561,-0.216027280477408,0.764044943820225,0.673684210526316,-0.871499176276771,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.124,-1.028,"9:9","147/150","C:D:T:G",1.66318697401976,3.35314758209503e-05,0.400956055116994,4.14805301676878,2.39021356042842,11.7435962131774,0.722312927852139,6.93631068428177e-05,4.15887146261268,2.21601547098056,12.6651520546836,1.22263744860911e-05,"lineage4","dr_mutations_pyrazinamide","ALA",0,"SRR3724660","SRR3724660","lineage4.3.2","cd","DRC","pnca_p.asp12ala","A","G","ASP","DA12","pnca_complex.pdb"
|
|
"D12A","L2","PZA","D","D12",12,"A",NA,"Pre-XDR","DM","hydrophilic","hydrophobic","acidic","non-polar","neg","non-polar",7.825,-2.924,0.904,0.896575,-1.267,1.36,64,80,-1.058,9,9,22,0.113989637305699,"helix",-1.4,5.01,0.0017967514733362,5.2760989010989,5.27609886875925,5.2752786493537,19.1276037177328,14,16,0,0,16,0,0,0,0,4,0,4,0,0,0,0,0,0,0,0,0,4,0,6,3,-0.740628166160081,0.768707482993197,0.0326552131061561,-0.216027280477408,0.764044943820225,0.673684210526316,-0.871499176276771,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.124,-1.028,"9:9","147/150","C:D:T:G",1.66318697401976,3.35314758209503e-05,0.400956055116994,4.14805301676878,2.39021356042842,11.7435962131774,0.722312927852139,6.93631068428177e-05,4.15887146261268,2.21601547098056,12.6651520546836,1.22263744860911e-05,"lineage2","dr_mutations_pyrazinamide","ALA",0,"SRR5709919,SAMN07236248","SRR5709919","lineage2.2.1","th","Thailand","pnca_p.asp12ala","A","G","ASP","DA12","pnca_complex.pdb"
|
|
"D12A","L3","PZA","D","D12",12,"A",1,"Pre-XDR","DM","hydrophilic","hydrophobic","acidic","non-polar","neg","non-polar",7.825,-2.924,0.904,0.896575,-1.267,1.36,64,80,-1.058,9,9,22,0.113989637305699,"helix",-1.4,5.01,0.0017967514733362,5.2760989010989,5.27609886875925,5.2752786493537,19.1276037177328,14,16,0,0,16,0,0,0,0,4,0,4,0,0,0,0,0,0,0,0,0,4,0,6,3,-0.740628166160081,0.768707482993197,0.0326552131061561,-0.216027280477408,0.764044943820225,0.673684210526316,-0.871499176276771,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.124,-1.028,"9:9","147/150","C:D:T:G",1.66318697401976,3.35314758209503e-05,0.400956055116994,4.14805301676878,2.39021356042842,11.7435962131774,0.722312927852139,6.93631068428177e-05,4.15887146261268,2.21601547098056,12.6651520546836,1.22263744860911e-05,"lineage3","dr_mutations_pyrazinamide","ALA",0,"ERR2510607","ERR2510607","lineage3","pk","Pakistan","pnca_p.asp12ala","A","G","ASP","DA12","pnca_complex.pdb"
|
|
"D12E","L2","PZA","D","D12",12,"E",NA,"MDR","DM","hydrophilic","hydrophilic","acidic","acidic","neg","neg",7.825,-0.42,-0.21,2.1586,-2.035,-0.02,69,80,-1.058,9,9,22,0.113989637305699,"helix",-1.4,5.01,0.0005749604714675,34.0379426644182,34.0375872334386,34.0436365315203,23.2409378193551,-8,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,-3,0,-3,-2,0,0,0,0,-0.106382978723404,-0.0542635658914728,0.0786209107001071,-0.346973572037511,-0.0052356020942408,0.726315789473684,-0.871499176276771,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.124,-1.028,"9:9","147/150","C:D:T:G",3.52746542085928,0.0009482725856347,1.06716956280854,3.30544043214259,6.05331233477717,636.464952477748,1.53196330239691,2.88610345466244e-05,4.53968810533409,4.36820226973726,1521.29182901896,1.42922316872435e-06,"lineage2","dr_mutations_pyrazinamide","GLU",0,"ERR234215","ERR234215","lineage2.2.1","mn","Mongolia","pnca_p.asp12glu","A","G","ASP","DA12","pnca_complex.pdb"
|
|
"D12E","L2","PZA","D","D12",12,"E",NA,"MDR","DM","hydrophilic","hydrophilic","acidic","acidic","neg","neg",7.825,-0.42,-0.21,2.1586,-2.035,-0.02,69,80,-1.058,9,9,22,0.113989637305699,"helix",-1.4,5.01,0.0005749604714675,34.0379426644182,34.0375872334386,34.0436365315203,23.2409378193551,-8,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,-3,0,-3,-2,0,0,0,0,-0.106382978723404,-0.0542635658914728,0.0786209107001071,-0.346973572037511,-0.0052356020942408,0.726315789473684,-0.871499176276771,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.124,-1.028,"9:9","147/150","C:D:T:G",3.52746542085928,0.0009482725856347,1.06716956280854,3.30544043214259,6.05331233477717,636.464952477748,1.53196330239691,2.88610345466244e-05,4.53968810533409,4.36820226973726,1521.29182901896,1.42922316872435e-06,"lineage2","dr_mutations_pyrazinamide","GLU",0,"SAMN02414978","SRR1163041_SRR1165495_SRR1163004_SRR1165591","lineage2.2.1","se","Sweden","pnca_p.asp12glu","A","G","ASP","DA12","pnca_complex.pdb"
|
|
"D12E","L2","PZA","D","D12",12,"E",1,"MDR","DM","hydrophilic","hydrophilic","acidic","acidic","neg","neg",7.825,-0.42,-0.21,2.1586,-2.035,-0.02,69,80,-1.058,9,9,22,0.113989637305699,"helix",-1.4,5.01,0.0005749604714675,34.0379426644182,34.0375872334386,34.0436365315203,23.2409378193551,-8,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,-3,0,-3,-2,0,0,0,0,-0.106382978723404,-0.0542635658914728,0.0786209107001071,-0.346973572037511,-0.0052356020942408,0.726315789473684,-0.871499176276771,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.124,-1.028,"9:9","147/150","C:D:T:G",3.52746542085928,0.0009482725856347,1.06716956280854,3.30544043214259,6.05331233477717,636.464952477748,1.53196330239691,2.88610345466244e-05,4.53968810533409,4.36820226973726,1521.29182901896,1.42922316872435e-06,"lineage2","dr_mutations_pyrazinamide","GLU",0,"14MT_9935","SRR5533151","lineage2.2.1.1","pg","","pnca_p.asp12glu","A","G","ASP","DA12","pnca_complex.pdb"
|
|
"D12E","L2","PZA","D","D12",12,"E",1,"MDR","DM","hydrophilic","hydrophilic","acidic","acidic","neg","neg",7.825,-0.42,-0.21,2.1586,-2.035,-0.02,69,80,-1.058,9,9,22,0.113989637305699,"helix",-1.4,5.01,0.0005749604714675,34.0379426644182,34.0375872334386,34.0436365315203,23.2409378193551,-8,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,-3,0,-3,-2,0,0,0,0,-0.106382978723404,-0.0542635658914728,0.0786209107001071,-0.346973572037511,-0.0052356020942408,0.726315789473684,-0.871499176276771,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.124,-1.028,"9:9","147/150","C:D:T:G",3.52746542085928,0.0009482725856347,1.06716956280854,3.30544043214259,6.05331233477717,636.464952477748,1.53196330239691,2.88610345466244e-05,4.53968810533409,4.36820226973726,1521.29182901896,1.42922316872435e-06,"lineage2","dr_mutations_pyrazinamide","GLU",0,"14MT_20852","SRR5548263","lineage2.2.1.1","pg","","pnca_p.asp12glu","A","G","ASP","DA12","pnca_complex.pdb"
|
|
"D12E","L2","PZA","D","D12",12,"E",NA,"MDR","DM","hydrophilic","hydrophilic","acidic","acidic","neg","neg",7.825,-0.42,-0.21,2.1586,-2.035,-0.02,69,80,-1.058,9,9,22,0.113989637305699,"helix",-1.4,5.01,0.0005749604714675,34.0379426644182,34.0375872334386,34.0436365315203,23.2409378193551,-8,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,-3,0,-3,-2,0,0,0,0,-0.106382978723404,-0.0542635658914728,0.0786209107001071,-0.346973572037511,-0.0052356020942408,0.726315789473684,-0.871499176276771,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.124,-1.028,"9:9","147/150","C:D:T:G",3.52746542085928,0.0009482725856347,1.06716956280854,3.30544043214259,6.05331233477717,636.464952477748,1.53196330239691,2.88610345466244e-05,4.53968810533409,4.36820226973726,1521.29182901896,1.42922316872435e-06,"lineage2","dr_mutations_pyrazinamide","GLU",0,"SRR6079966","SRR6079966","lineage2.2.1.1","au","","pnca_p.asp12glu","A","G","ASP","DA12","pnca_complex.pdb"
|
|
"D12E","L2","PZA","D","D12",12,"E",1,"MDR","DM","hydrophilic","hydrophilic","acidic","acidic","neg","neg",7.825,-0.42,-0.21,2.1586,-2.035,-0.02,69,80,-1.058,9,9,22,0.113989637305699,"helix",-1.4,5.01,0.0005749604714675,34.0379426644182,34.0375872334386,34.0436365315203,23.2409378193551,-8,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,-3,0,-3,-2,0,0,0,0,-0.106382978723404,-0.0542635658914728,0.0786209107001071,-0.346973572037511,-0.0052356020942408,0.726315789473684,-0.871499176276771,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.124,-1.028,"9:9","147/150","C:D:T:G",3.52746542085928,0.0009482725856347,1.06716956280854,3.30544043214259,6.05331233477717,636.464952477748,1.53196330239691,2.88610345466244e-05,4.53968810533409,4.36820226973726,1521.29182901896,1.42922316872435e-06,"lineage2","dr_mutations_pyrazinamide","GLU",0,"13MT_2964","SRR5525984","lineage2.2.1.1","pg","","pnca_p.asp12glu","A","G","ASP","DA12","pnca_complex.pdb"
|
|
"D12E","L2","PZA","D","D12",12,"E",1,"MDR","DM","hydrophilic","hydrophilic","acidic","acidic","neg","neg",7.825,-0.42,-0.21,2.1586,-2.035,-0.02,69,80,-1.058,9,9,22,0.113989637305699,"helix",-1.4,5.01,0.0005749604714675,34.0379426644182,34.0375872334386,34.0436365315203,23.2409378193551,-8,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,-3,0,-3,-2,0,0,0,0,-0.106382978723404,-0.0542635658914728,0.0786209107001071,-0.346973572037511,-0.0052356020942408,0.726315789473684,-0.871499176276771,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.124,-1.028,"9:9","147/150","C:D:T:G",3.52746542085928,0.0009482725856347,1.06716956280854,3.30544043214259,6.05331233477717,636.464952477748,1.53196330239691,2.88610345466244e-05,4.53968810533409,4.36820226973726,1521.29182901896,1.42922316872435e-06,"lineage2","dr_mutations_pyrazinamide","GLU",0,"14MT_21042","SRR5533179","lineage2.2.1.1","pg","","pnca_p.asp12glu","A","G","ASP","DA12","pnca_complex.pdb"
|
|
"D12E","L2","PZA","D","D12",12,"E",0,"MDR","DM","hydrophilic","hydrophilic","acidic","acidic","neg","neg",7.825,-0.42,-0.21,2.1586,-2.035,-0.02,69,80,-1.058,9,9,22,0.113989637305699,"helix",-1.4,5.01,0.0005749604714675,34.0379426644182,34.0375872334386,34.0436365315203,23.2409378193551,-8,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,-3,0,-3,-2,0,0,0,0,-0.106382978723404,-0.0542635658914728,0.0786209107001071,-0.346973572037511,-0.0052356020942408,0.726315789473684,-0.871499176276771,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.124,-1.028,"9:9","147/150","C:D:T:G",3.52746542085928,0.0009482725856347,1.06716956280854,3.30544043214259,6.05331233477717,636.464952477748,1.53196330239691,2.88610345466244e-05,4.53968810533409,4.36820226973726,1521.29182901896,1.42922316872435e-06,"lineage2","dr_mutations_pyrazinamide","GLU",0,"ERR2516780","ERR2516780","lineage2.2.1","gb","UK","pnca_p.asp12glu","A","G","ASP","DA12","pnca_complex.pdb"
|
|
"D12E","L2","PZA","D","D12",12,"E",1,"MDR","DM","hydrophilic","hydrophilic","acidic","acidic","neg","neg",7.825,-0.42,-0.21,2.1586,-2.035,-0.02,69,80,-1.058,9,9,22,0.113989637305699,"helix",-1.4,5.01,0.0005749604714675,34.0379426644182,34.0375872334386,34.0436365315203,23.2409378193551,-8,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,-3,0,-3,-2,0,0,0,0,-0.106382978723404,-0.0542635658914728,0.0786209107001071,-0.346973572037511,-0.0052356020942408,0.726315789473684,-0.871499176276771,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.124,-1.028,"9:9","147/150","C:D:T:G",3.52746542085928,0.0009482725856347,1.06716956280854,3.30544043214259,6.05331233477717,636.464952477748,1.53196330239691,2.88610345466244e-05,4.53968810533409,4.36820226973726,1521.29182901896,1.42922316872435e-06,"lineage2","dr_mutations_pyrazinamide","GLU",0,"15MT_4694","SRR5552561","lineage2.2.1.1","pg","","pnca_p.asp12glu","A","G","ASP","DA12","pnca_complex.pdb"
|
|
"D12E","L2","PZA","D","D12",12,"E",1,"MDR","DM","hydrophilic","hydrophilic","acidic","acidic","neg","neg",7.825,-0.42,-0.21,2.1586,-2.035,-0.02,69,80,-1.058,9,9,22,0.113989637305699,"helix",-1.4,5.01,0.0005749604714675,34.0379426644182,34.0375872334386,34.0436365315203,23.2409378193551,-8,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,-3,0,-3,-2,0,0,0,0,-0.106382978723404,-0.0542635658914728,0.0786209107001071,-0.346973572037511,-0.0052356020942408,0.726315789473684,-0.871499176276771,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.124,-1.028,"9:9","147/150","C:D:T:G",3.52746542085928,0.0009482725856347,1.06716956280854,3.30544043214259,6.05331233477717,636.464952477748,1.53196330239691,2.88610345466244e-05,4.53968810533409,4.36820226973726,1521.29182901896,1.42922316872435e-06,"lineage2","dr_mutations_pyrazinamide","GLU",0,"ERR2516867","ERR2516867","lineage2.2.1","gb","UK","pnca_p.asp12glu","A","G","ASP","DA12","pnca_complex.pdb"
|
|
"D12E","L2","PZA","D","D12",12,"E",1,"MDR","DM","hydrophilic","hydrophilic","acidic","acidic","neg","neg",7.825,-0.42,-0.21,2.1586,-2.035,-0.02,69,80,-1.058,9,9,22,0.113989637305699,"helix",-1.4,5.01,0.0005749604714675,34.0379426644182,34.0375872334386,34.0436365315203,23.2409378193551,-8,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,-3,0,-3,-2,0,0,0,0,-0.106382978723404,-0.0542635658914728,0.0786209107001071,-0.346973572037511,-0.0052356020942408,0.726315789473684,-0.871499176276771,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.124,-1.028,"9:9","147/150","C:D:T:G",3.52746542085928,0.0009482725856347,1.06716956280854,3.30544043214259,6.05331233477717,636.464952477748,1.53196330239691,2.88610345466244e-05,4.53968810533409,4.36820226973726,1521.29182901896,1.42922316872435e-06,"lineage2","dr_mutations_pyrazinamide","GLU",0,"ERR2516829","ERR2516829","lineage2.2.1","gb","UK","pnca_p.asp12glu","A","G","ASP","DA12","pnca_complex.pdb"
|
|
"D12G","L4","PZA","D","D12",12,"G",1,"Pre-XDR","DM","hydrophilic","hydrophobic","acidic","neutral","neg","non-polar",7.825,-3.008,0.079,2.26095,-1.546,0.46,67,80,-1.058,9,9,22,0.113989637305699,"helix",-1.4,5.01,0.0005030904125341,29.1630847029077,29.1630732435187,29.1293325978315,18.6717493808583,20,16,0,0,16,0,0,0,0,4,0,4,0,0,0,0,0,0,0,0,0,6,0,15,17,-0.761904761904762,0.0671768707482993,0.0823487204889313,-0.263597612958227,0.258426966292135,0.705263157894737,-0.871499176276771,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.124,-1.028,"9:9","147/150","C:D:T:G",3.37290329402598,0.001789077082818,1.07995768762031,3.12318096596747,4.97876379053956,550.894323519286,1.46483345924118,0.0001485295621003,3.828187099348,3.53443753556636,1331.56873199938,1.55265977742841e-05,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR2516704","ERR2516704","lineage4.3.2","pe","Peru","pnca_p.asp12gly","A","G","ASP","DA12","pnca_complex.pdb"
|
|
"D12G","L4","PZA","D","D12",12,"G",1,"Pre-XDR","DM","hydrophilic","hydrophobic","acidic","neutral","neg","non-polar",7.825,-3.008,0.079,2.26095,-1.546,0.46,67,80,-1.058,9,9,22,0.113989637305699,"helix",-1.4,5.01,0.0005030904125341,29.1630847029077,29.1630732435187,29.1293325978315,18.6717493808583,20,16,0,0,16,0,0,0,0,4,0,4,0,0,0,0,0,0,0,0,0,6,0,15,17,-0.761904761904762,0.0671768707482993,0.0823487204889313,-0.263597612958227,0.258426966292135,0.705263157894737,-0.871499176276771,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.124,-1.028,"9:9","147/150","C:D:T:G",3.37290329402598,0.001789077082818,1.07995768762031,3.12318096596747,4.97876379053956,550.894323519286,1.46483345924118,0.0001485295621003,3.828187099348,3.53443753556636,1331.56873199938,1.55265977742841e-05,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR2516409","ERR2516409","lineage4.3.2","pe","Peru","pnca_p.asp12gly","A","G","ASP","DA12","pnca_complex.pdb"
|
|
"D12G","L2","PZA","D","D12",12,"G",NA,"Pre-XDR","DM","hydrophilic","hydrophobic","acidic","neutral","neg","non-polar",7.825,-3.008,0.079,2.26095,-1.546,0.46,67,80,-1.058,9,9,22,0.113989637305699,"helix",-1.4,5.01,0.0005030904125341,29.1630847029077,29.1630732435187,29.1293325978315,18.6717493808583,20,16,0,0,16,0,0,0,0,4,0,4,0,0,0,0,0,0,0,0,0,6,0,15,17,-0.761904761904762,0.0671768707482993,0.0823487204889313,-0.263597612958227,0.258426966292135,0.705263157894737,-0.871499176276771,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.124,-1.028,"9:9","147/150","C:D:T:G",3.37290329402598,0.001789077082818,1.07995768762031,3.12318096596747,4.97876379053956,550.894323519286,1.46483345924118,0.0001485295621003,3.828187099348,3.53443753556636,1331.56873199938,1.55265977742841e-05,"lineage2","dr_mutations_pyrazinamide","GLY",0,"SAMN02381027","SRR1049687_SRR1049688_SRR1140694_SRR1062917","lineage2.2.1","ug","Uganda","pnca_p.asp12gly","A","G","ASP","DA12","pnca_complex.pdb"
|
|
"D12G","L2","PZA","D","D12",12,"G",NA,"Pre-XDR","DM","hydrophilic","hydrophobic","acidic","neutral","neg","non-polar",7.825,-3.008,0.079,2.26095,-1.546,0.46,67,80,-1.058,9,9,22,0.113989637305699,"helix",-1.4,5.01,0.0005030904125341,29.1630847029077,29.1630732435187,29.1293325978315,18.6717493808583,20,16,0,0,16,0,0,0,0,4,0,4,0,0,0,0,0,0,0,0,0,6,0,15,17,-0.761904761904762,0.0671768707482993,0.0823487204889313,-0.263597612958227,0.258426966292135,0.705263157894737,-0.871499176276771,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.124,-1.028,"9:9","147/150","C:D:T:G",3.37290329402598,0.001789077082818,1.07995768762031,3.12318096596747,4.97876379053956,550.894323519286,1.46483345924118,0.0001485295621003,3.828187099348,3.53443753556636,1331.56873199938,1.55265977742841e-05,"lineage2","dr_mutations_pyrazinamide","GLY",0,"BGI_LN077,SRR671787","SRR671787","lineage2.2.1","cn","China","pnca_p.asp12gly","A","G","ASP","DA12","pnca_complex.pdb"
|
|
"D12G","L2","PZA","D","D12",12,"G",1,"MDR","DM","hydrophilic","hydrophobic","acidic","neutral","neg","non-polar",7.825,-3.008,0.079,2.26095,-1.546,0.46,67,80,-1.058,9,9,22,0.113989637305699,"helix",-1.4,5.01,0.0005030904125341,29.1630847029077,29.1630732435187,29.1293325978315,18.6717493808583,20,16,0,0,16,0,0,0,0,4,0,4,0,0,0,0,0,0,0,0,0,6,0,15,17,-0.761904761904762,0.0671768707482993,0.0823487204889313,-0.263597612958227,0.258426966292135,0.705263157894737,-0.871499176276771,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.124,-1.028,"9:9","147/150","C:D:T:G",3.37290329402598,0.001789077082818,1.07995768762031,3.12318096596747,4.97876379053956,550.894323519286,1.46483345924118,0.0001485295621003,3.828187099348,3.53443753556636,1331.56873199938,1.55265977742841e-05,"lineage2","dr_mutations_pyrazinamide","GLY",0,"MDR_14306","SRR6824376","lineage2.2.1","cn","China: Guangfeng County, Shangrao City, Jiangxi Province","pnca_p.asp12gly","A","G","ASP","DA12","pnca_complex.pdb"
|
|
"D12G","L2","PZA","D","D12",12,"G",1,"MDR","DM","hydrophilic","hydrophobic","acidic","neutral","neg","non-polar",7.825,-3.008,0.079,2.26095,-1.546,0.46,67,80,-1.058,9,9,22,0.113989637305699,"helix",-1.4,5.01,0.0005030904125341,29.1630847029077,29.1630732435187,29.1293325978315,18.6717493808583,20,16,0,0,16,0,0,0,0,4,0,4,0,0,0,0,0,0,0,0,0,6,0,15,17,-0.761904761904762,0.0671768707482993,0.0823487204889313,-0.263597612958227,0.258426966292135,0.705263157894737,-0.871499176276771,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.124,-1.028,"9:9","147/150","C:D:T:G",3.37290329402598,0.001789077082818,1.07995768762031,3.12318096596747,4.97876379053956,550.894323519286,1.46483345924118,0.0001485295621003,3.828187099348,3.53443753556636,1331.56873199938,1.55265977742841e-05,"lineage2","dr_mutations_pyrazinamide","GLY",0,"ERR1034754","ERR1034754","lineage2.2.1","pe","Peru","pnca_p.asp12gly","A","G","ASP","DA12","pnca_complex.pdb"
|
|
"D12G","L2","PZA","D","D12",12,"G",0,"Pre-XDR","DM","hydrophilic","hydrophobic","acidic","neutral","neg","non-polar",7.825,-3.008,0.079,2.26095,-1.546,0.46,67,80,-1.058,9,9,22,0.113989637305699,"helix",-1.4,5.01,0.0005030904125341,29.1630847029077,29.1630732435187,29.1293325978315,18.6717493808583,20,16,0,0,16,0,0,0,0,4,0,4,0,0,0,0,0,0,0,0,0,6,0,15,17,-0.761904761904762,0.0671768707482993,0.0823487204889313,-0.263597612958227,0.258426966292135,0.705263157894737,-0.871499176276771,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.124,-1.028,"9:9","147/150","C:D:T:G",3.37290329402598,0.001789077082818,1.07995768762031,3.12318096596747,4.97876379053956,550.894323519286,1.46483345924118,0.0001485295621003,3.828187099348,3.53443753556636,1331.56873199938,1.55265977742841e-05,"lineage2","dr_mutations_pyrazinamide","GLY",0,"2403N-sc-2012-10-11T13:40:16Z-1494317,ERR229998","ERR229998","lineage2.2.1","ru","Russia,Samara","pnca_p.asp12gly","A","G","ASP","DA12","pnca_complex.pdb"
|
|
"D12G","L2","PZA","D","D12",12,"G",1,"MDR","DM","hydrophilic","hydrophobic","acidic","neutral","neg","non-polar",7.825,-3.008,0.079,2.26095,-1.546,0.46,67,80,-1.058,9,9,22,0.113989637305699,"helix",-1.4,5.01,0.0005030904125341,29.1630847029077,29.1630732435187,29.1293325978315,18.6717493808583,20,16,0,0,16,0,0,0,0,4,0,4,0,0,0,0,0,0,0,0,0,6,0,15,17,-0.761904761904762,0.0671768707482993,0.0823487204889313,-0.263597612958227,0.258426966292135,0.705263157894737,-0.871499176276771,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.124,-1.028,"9:9","147/150","C:D:T:G",3.37290329402598,0.001789077082818,1.07995768762031,3.12318096596747,4.97876379053956,550.894323519286,1.46483345924118,0.0001485295621003,3.828187099348,3.53443753556636,1331.56873199938,1.55265977742841e-05,"lineage2","dr_mutations_pyrazinamide","GLY",0,"ERR2516482","ERR2516482","lineage2.2.1","pe","Peru","pnca_p.asp12gly","A","G","ASP","DA12","pnca_complex.pdb"
|
|
"D12G","L2","PZA","D","D12",12,"G",NA,"MDR","DM","hydrophilic","hydrophobic","acidic","neutral","neg","non-polar",7.825,-3.008,0.079,2.26095,-1.546,0.46,67,80,-1.058,9,9,22,0.113989637305699,"helix",-1.4,5.01,0.0005030904125341,29.1630847029077,29.1630732435187,29.1293325978315,18.6717493808583,20,16,0,0,16,0,0,0,0,4,0,4,0,0,0,0,0,0,0,0,0,6,0,15,17,-0.761904761904762,0.0671768707482993,0.0823487204889313,-0.263597612958227,0.258426966292135,0.705263157894737,-0.871499176276771,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.124,-1.028,"9:9","147/150","C:D:T:G",3.37290329402598,0.001789077082818,1.07995768762031,3.12318096596747,4.97876379053956,550.894323519286,1.46483345924118,0.0001485295621003,3.828187099348,3.53443753556636,1331.56873199938,1.55265977742841e-05,"lineage2","dr_mutations_pyrazinamide","GLY",0,"SRR5073521","SRR5073521","lineage2.2.1","vn","Vietnam","pnca_p.asp12gly","A","G","ASP","DA12","pnca_complex.pdb"
|
|
"D12G","L2","PZA","D","D12",12,"G",NA,"Pre-XDR","DM","hydrophilic","hydrophobic","acidic","neutral","neg","non-polar",7.825,-3.008,0.079,2.26095,-1.546,0.46,67,80,-1.058,9,9,22,0.113989637305699,"helix",-1.4,5.01,0.0005030904125341,29.1630847029077,29.1630732435187,29.1293325978315,18.6717493808583,20,16,0,0,16,0,0,0,0,4,0,4,0,0,0,0,0,0,0,0,0,6,0,15,17,-0.761904761904762,0.0671768707482993,0.0823487204889313,-0.263597612958227,0.258426966292135,0.705263157894737,-0.871499176276771,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.124,-1.028,"9:9","147/150","C:D:T:G",3.37290329402598,0.001789077082818,1.07995768762031,3.12318096596747,4.97876379053956,550.894323519286,1.46483345924118,0.0001485295621003,3.828187099348,3.53443753556636,1331.56873199938,1.55265977742841e-05,"lineage2","dr_mutations_pyrazinamide","GLY",0,"SRS796976","SRR1723464","lineage2.2.1","cn","China:Sichuan","pnca_p.asp12gly","A","G","ASP","DA12","pnca_complex.pdb"
|
|
"D12G","L4","PZA","D","D12",12,"G",1,"MDR","DM","hydrophilic","hydrophobic","acidic","neutral","neg","non-polar",7.825,-3.008,0.079,2.26095,-1.546,0.46,67,80,-1.058,9,9,22,0.113989637305699,"helix",-1.4,5.01,0.0005030904125341,29.1630847029077,29.1630732435187,29.1293325978315,18.6717493808583,20,16,0,0,16,0,0,0,0,4,0,4,0,0,0,0,0,0,0,0,0,6,0,15,17,-0.761904761904762,0.0671768707482993,0.0823487204889313,-0.263597612958227,0.258426966292135,0.705263157894737,-0.871499176276771,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.124,-1.028,"9:9","147/150","C:D:T:G",3.37290329402598,0.001789077082818,1.07995768762031,3.12318096596747,4.97876379053956,550.894323519286,1.46483345924118,0.0001485295621003,3.828187099348,3.53443753556636,1331.56873199938,1.55265977742841e-05,"lineage4","dr_mutations_pyrazinamide","GLY",0,"MDR_23342","SRR6824480","lineage4.2.2","cn","China: Fucheng District, Mianyang City, Sichuan Province","pnca_p.asp12gly","A","G","ASP","DA12","pnca_complex.pdb"
|
|
"D12N","L2","PZA","D","D12",12,"N",NA,"Pre-XDR","DM","hydrophilic","hydrophilic","acidic","neutral","neg","polar",7.825,-1.928,0.018,1.58277,-2.236,0.09,79,85,-1.058,9,9,22,0.113989637305699,"helix",-1.4,5.01,0.000646830530401,17.0174957841484,17.0174574529133,17.0076332291246,19.306440114962,0,16,0,0,16,0,0,0,0,2,0,2,0,0,0,0,0,-7,0,-5,-2,0,0,0,0,-0.488348530901722,0.0153061224489795,0.0576479286708091,-0.381244671781756,0.0505617977528089,0.831578947368421,-0.871499176276771,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.124,-1.028,"9:9","147/150","C:D:T:G",2.83423972614077,0.0004057565735776,0.801467871651648,3.53631109416779,4.11022012991606,114.25813127402,1.23089565168614,0.0001105447439914,3.95646190174896,3.23648804294829,167.757055506696,1.11330211002346e-05,"lineage2","dr_mutations_pyrazinamide","ASN",0,"SRS797316","SRR1723847","lineage2.2.1","cn","China:Shanxi","pnca_p.asp12asn","A","G","ASP","DA12","pnca_complex.pdb"
|
|
"D12N","L2","PZA","D","D12",12,"N",0,"XDR","DM","hydrophilic","hydrophilic","acidic","neutral","neg","polar",7.825,-1.928,0.018,1.58277,-2.236,0.09,79,85,-1.058,9,9,22,0.113989637305699,"helix",-1.4,5.01,0.000646830530401,17.0174957841484,17.0174574529133,17.0076332291246,19.306440114962,0,16,0,0,16,0,0,0,0,2,0,2,0,0,0,0,0,-7,0,-5,-2,0,0,0,0,-0.488348530901722,0.0153061224489795,0.0576479286708091,-0.381244671781756,0.0505617977528089,0.831578947368421,-0.871499176276771,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.124,-1.028,"9:9","147/150","C:D:T:G",2.83423972614077,0.0004057565735776,0.801467871651648,3.53631109416779,4.11022012991606,114.25813127402,1.23089565168614,0.0001105447439914,3.95646190174896,3.23648804294829,167.757055506696,1.11330211002346e-05,"lineage2","dr_mutations_pyrazinamide","ASN",0,"IEMDR04","ERR1952141","lineage2.2.1","ie","Ireland","pnca_p.asp12asn","A","G","ASP","DA12","pnca_complex.pdb"
|
|
"D12N","L2","PZA","D","D12",12,"N",1,"Pre-XDR","DM","hydrophilic","hydrophilic","acidic","neutral","neg","polar",7.825,-1.928,0.018,1.58277,-2.236,0.09,79,85,-1.058,9,9,22,0.113989637305699,"helix",-1.4,5.01,0.000646830530401,17.0174957841484,17.0174574529133,17.0076332291246,19.306440114962,0,16,0,0,16,0,0,0,0,2,0,2,0,0,0,0,0,-7,0,-5,-2,0,0,0,0,-0.488348530901722,0.0153061224489795,0.0576479286708091,-0.381244671781756,0.0505617977528089,0.831578947368421,-0.871499176276771,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.124,-1.028,"9:9","147/150","C:D:T:G",2.83423972614077,0.0004057565735776,0.801467871651648,3.53631109416779,4.11022012991606,114.25813127402,1.23089565168614,0.0001105447439914,3.95646190174896,3.23648804294829,167.757055506696,1.11330211002346e-05,"lineage2","dr_mutations_pyrazinamide","ASN",0,"MDR_4148","SRR6824530","lineage2.2.1","cn","China: Pingding County, Yangquan City, Shanxi Province","pnca_p.asp12asn","A","G","ASP","DA12","pnca_complex.pdb"
|
|
"D12N","L2","PZA","D","D12",12,"N",1,"Pre-XDR","DM","hydrophilic","hydrophilic","acidic","neutral","neg","polar",7.825,-1.928,0.018,1.58277,-2.236,0.09,79,85,-1.058,9,9,22,0.113989637305699,"helix",-1.4,5.01,0.000646830530401,17.0174957841484,17.0174574529133,17.0076332291246,19.306440114962,0,16,0,0,16,0,0,0,0,2,0,2,0,0,0,0,0,-7,0,-5,-2,0,0,0,0,-0.488348530901722,0.0153061224489795,0.0576479286708091,-0.381244671781756,0.0505617977528089,0.831578947368421,-0.871499176276771,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.124,-1.028,"9:9","147/150","C:D:T:G",2.83423972614077,0.0004057565735776,0.801467871651648,3.53631109416779,4.11022012991606,114.25813127402,1.23089565168614,0.0001105447439914,3.95646190174896,3.23648804294829,167.757055506696,1.11330211002346e-05,"lineage2","dr_mutations_pyrazinamide","ASN",0,"ERR2516775","ERR2516775","lineage2.2.1","gb","UK","pnca_p.asp12asn","A","G","ASP","DA12","pnca_complex.pdb"
|
|
"D12N","L2","PZA","D","D12",12,"N",1,"Pre-XDR","DM","hydrophilic","hydrophilic","acidic","neutral","neg","polar",7.825,-1.928,0.018,1.58277,-2.236,0.09,79,85,-1.058,9,9,22,0.113989637305699,"helix",-1.4,5.01,0.000646830530401,17.0174957841484,17.0174574529133,17.0076332291246,19.306440114962,0,16,0,0,16,0,0,0,0,2,0,2,0,0,0,0,0,-7,0,-5,-2,0,0,0,0,-0.488348530901722,0.0153061224489795,0.0576479286708091,-0.381244671781756,0.0505617977528089,0.831578947368421,-0.871499176276771,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.124,-1.028,"9:9","147/150","C:D:T:G",2.83423972614077,0.0004057565735776,0.801467871651648,3.53631109416779,4.11022012991606,114.25813127402,1.23089565168614,0.0001105447439914,3.95646190174896,3.23648804294829,167.757055506696,1.11330211002346e-05,"lineage2","dr_mutations_pyrazinamide","ASN",0,"MDR_4145","SRR6824527","lineage2.2.1","cn","China: Pingding County, Yangquan City, Shanxi Province","pnca_p.asp12asn","A","G","ASP","DA12","pnca_complex.pdb"
|
|
"D12N","L4","PZA","D","D12",12,"N",NA,"MDR","DM","hydrophilic","hydrophilic","acidic","neutral","neg","polar",7.825,-1.928,0.018,1.58277,-2.236,0.09,79,85,-1.058,9,9,22,0.113989637305699,"helix",-1.4,5.01,0.000646830530401,17.0174957841484,17.0174574529133,17.0076332291246,19.306440114962,0,16,0,0,16,0,0,0,0,2,0,2,0,0,0,0,0,-7,0,-5,-2,0,0,0,0,-0.488348530901722,0.0153061224489795,0.0576479286708091,-0.381244671781756,0.0505617977528089,0.831578947368421,-0.871499176276771,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.124,-1.028,"9:9","147/150","C:D:T:G",2.83423972614077,0.0004057565735776,0.801467871651648,3.53631109416779,4.11022012991606,114.25813127402,1.23089565168614,0.0001105447439914,3.95646190174896,3.23648804294829,167.757055506696,1.11330211002346e-05,"lineage4","dr_mutations_pyrazinamide","ASN",0,"ERR2706921","ERR2706921","lineage4.6.1.2","cd","Democratic Republic of Congo","pnca_p.asp12asn","A","G","ASP","DA12","pnca_complex.pdb"
|
|
"D12N","L2","PZA","D","D12",12,"N",1,"XDR","DM","hydrophilic","hydrophilic","acidic","neutral","neg","polar",7.825,-1.928,0.018,1.58277,-2.236,0.09,79,85,-1.058,9,9,22,0.113989637305699,"helix",-1.4,5.01,0.000646830530401,17.0174957841484,17.0174574529133,17.0076332291246,19.306440114962,0,16,0,0,16,0,0,0,0,2,0,2,0,0,0,0,0,-7,0,-5,-2,0,0,0,0,-0.488348530901722,0.0153061224489795,0.0576479286708091,-0.381244671781756,0.0505617977528089,0.831578947368421,-0.871499176276771,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.124,-1.028,"9:9","147/150","C:D:T:G",2.83423972614077,0.0004057565735776,0.801467871651648,3.53631109416779,4.11022012991606,114.25813127402,1.23089565168614,0.0001105447439914,3.95646190174896,3.23648804294829,167.757055506696,1.11330211002346e-05,"lineage2","dr_mutations_pyrazinamide","ASN",0,"ERR2517112","ERR2517112","lineage2.2.1","gb","UK","pnca_p.asp12asn","A","G","ASP","DA12","pnca_complex.pdb"
|
|
"D12N","L2","PZA","D","D12",12,"N",NA,"Pre-XDR","DM","hydrophilic","hydrophilic","acidic","neutral","neg","polar",7.825,-1.928,0.018,1.58277,-2.236,0.09,79,85,-1.058,9,9,22,0.113989637305699,"helix",-1.4,5.01,0.000646830530401,17.0174957841484,17.0174574529133,17.0076332291246,19.306440114962,0,16,0,0,16,0,0,0,0,2,0,2,0,0,0,0,0,-7,0,-5,-2,0,0,0,0,-0.488348530901722,0.0153061224489795,0.0576479286708091,-0.381244671781756,0.0505617977528089,0.831578947368421,-0.871499176276771,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.124,-1.028,"9:9","147/150","C:D:T:G",2.83423972614077,0.0004057565735776,0.801467871651648,3.53631109416779,4.11022012991606,114.25813127402,1.23089565168614,0.0001105447439914,3.95646190174896,3.23648804294829,167.757055506696,1.11330211002346e-05,"lineage2","dr_mutations_pyrazinamide","ASN",0,"SRS797313","SRR1723843","lineage2.2.1","cn","China:Shanxi","pnca_p.asp12asn","A","G","ASP","DA12","pnca_complex.pdb"
|
|
"D12N","L2","PZA","D","D12",12,"N",NA,"MDR","DM","hydrophilic","hydrophilic","acidic","neutral","neg","polar",7.825,-1.928,0.018,1.58277,-2.236,0.09,79,85,-1.058,9,9,22,0.113989637305699,"helix",-1.4,5.01,0.000646830530401,17.0174957841484,17.0174574529133,17.0076332291246,19.306440114962,0,16,0,0,16,0,0,0,0,2,0,2,0,0,0,0,0,-7,0,-5,-2,0,0,0,0,-0.488348530901722,0.0153061224489795,0.0576479286708091,-0.381244671781756,0.0505617977528089,0.831578947368421,-0.871499176276771,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.124,-1.028,"9:9","147/150","C:D:T:G",2.83423972614077,0.0004057565735776,0.801467871651648,3.53631109416779,4.11022012991606,114.25813127402,1.23089565168614,0.0001105447439914,3.95646190174896,3.23648804294829,167.757055506696,1.11330211002346e-05,"lineage2","dr_mutations_pyrazinamide","ASN",0,"SRR5073698","SRR5073698","lineage2.2.1.1","vn","Vietnam","pnca_p.asp12asn","A","G","ASP","DA12","pnca_complex.pdb"
|
|
"D12N","L2","PZA","D","D12",12,"N",NA,"Pre-XDR","DM","hydrophilic","hydrophilic","acidic","neutral","neg","polar",7.825,-1.928,0.018,1.58277,-2.236,0.09,79,85,-1.058,9,9,22,0.113989637305699,"helix",-1.4,5.01,0.000646830530401,17.0174957841484,17.0174574529133,17.0076332291246,19.306440114962,0,16,0,0,16,0,0,0,0,2,0,2,0,0,0,0,0,-7,0,-5,-2,0,0,0,0,-0.488348530901722,0.0153061224489795,0.0576479286708091,-0.381244671781756,0.0505617977528089,0.831578947368421,-0.871499176276771,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.124,-1.028,"9:9","147/150","C:D:T:G",2.83423972614077,0.0004057565735776,0.801467871651648,3.53631109416779,4.11022012991606,114.25813127402,1.23089565168614,0.0001105447439914,3.95646190174896,3.23648804294829,167.757055506696,1.11330211002346e-05,"lineage2","dr_mutations_pyrazinamide","ASN",0,"ERR158606","ERR158606","lineage2.2.1","gb","UK","pnca_p.asp12asn","A","G","ASP","DA12","pnca_complex.pdb"
|
|
"D12N","L2","PZA","D","D12",12,"N",NA,"Pre-XDR","DM","hydrophilic","hydrophilic","acidic","neutral","neg","polar",7.825,-1.928,0.018,1.58277,-2.236,0.09,79,85,-1.058,9,9,22,0.113989637305699,"helix",-1.4,5.01,0.000646830530401,17.0174957841484,17.0174574529133,17.0076332291246,19.306440114962,0,16,0,0,16,0,0,0,0,2,0,2,0,0,0,0,0,-7,0,-5,-2,0,0,0,0,-0.488348530901722,0.0153061224489795,0.0576479286708091,-0.381244671781756,0.0505617977528089,0.831578947368421,-0.871499176276771,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.124,-1.028,"9:9","147/150","C:D:T:G",2.83423972614077,0.0004057565735776,0.801467871651648,3.53631109416779,4.11022012991606,114.25813127402,1.23089565168614,0.0001105447439914,3.95646190174896,3.23648804294829,167.757055506696,1.11330211002346e-05,"lineage2","dr_mutations_pyrazinamide","ASN",0,"SRS797314","SRR1723845_SRR1723844","lineage2.2.1","cn","China:Shanxi","pnca_p.asp12asn","A","G","ASP","DA12","pnca_complex.pdb"
|
|
"D12N","L2","PZA","D","D12",12,"N",NA,"Pre-XDR","DM","hydrophilic","hydrophilic","acidic","neutral","neg","polar",7.825,-1.928,0.018,1.58277,-2.236,0.09,79,85,-1.058,9,9,22,0.113989637305699,"helix",-1.4,5.01,0.000646830530401,17.0174957841484,17.0174574529133,17.0076332291246,19.306440114962,0,16,0,0,16,0,0,0,0,2,0,2,0,0,0,0,0,-7,0,-5,-2,0,0,0,0,-0.488348530901722,0.0153061224489795,0.0576479286708091,-0.381244671781756,0.0505617977528089,0.831578947368421,-0.871499176276771,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.124,-1.028,"9:9","147/150","C:D:T:G",2.83423972614077,0.0004057565735776,0.801467871651648,3.53631109416779,4.11022012991606,114.25813127402,1.23089565168614,0.0001105447439914,3.95646190174896,3.23648804294829,167.757055506696,1.11330211002346e-05,"lineage2","dr_mutations_pyrazinamide","ASN",0,"SRS797315","SRR1723846","lineage2.2.1","cn","China:Shanxi","pnca_p.asp12asn","A","G","ASP","DA12","pnca_complex.pdb"
|
|
"D12N","L2","PZA","D","D12",12,"N",1,"Pre-XDR","DM","hydrophilic","hydrophilic","acidic","neutral","neg","polar",7.825,-1.928,0.018,1.58277,-2.236,0.09,79,85,-1.058,9,9,22,0.113989637305699,"helix",-1.4,5.01,0.000646830530401,17.0174957841484,17.0174574529133,17.0076332291246,19.306440114962,0,16,0,0,16,0,0,0,0,2,0,2,0,0,0,0,0,-7,0,-5,-2,0,0,0,0,-0.488348530901722,0.0153061224489795,0.0576479286708091,-0.381244671781756,0.0505617977528089,0.831578947368421,-0.871499176276771,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.124,-1.028,"9:9","147/150","C:D:T:G",2.83423972614077,0.0004057565735776,0.801467871651648,3.53631109416779,4.11022012991606,114.25813127402,1.23089565168614,0.0001105447439914,3.95646190174896,3.23648804294829,167.757055506696,1.11330211002346e-05,"lineage2","dr_mutations_pyrazinamide","ASN",0,"MDR_4147","SRR6824471","lineage2.2.1","cn","China: Pingding County, Yangquan City, Shanxi Province","pnca_p.asp12asn","A","G","ASP","DA12","pnca_complex.pdb"
|
|
"D12N","L2","PZA","D","D12",12,"N",0,"Pre-XDR","DM","hydrophilic","hydrophilic","acidic","neutral","neg","polar",7.825,-1.928,0.018,1.58277,-2.236,0.09,79,85,-1.058,9,9,22,0.113989637305699,"helix",-1.4,5.01,0.000646830530401,17.0174957841484,17.0174574529133,17.0076332291246,19.306440114962,0,16,0,0,16,0,0,0,0,2,0,2,0,0,0,0,0,-7,0,-5,-2,0,0,0,0,-0.488348530901722,0.0153061224489795,0.0576479286708091,-0.381244671781756,0.0505617977528089,0.831578947368421,-0.871499176276771,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.124,-1.028,"9:9","147/150","C:D:T:G",2.83423972614077,0.0004057565735776,0.801467871651648,3.53631109416779,4.11022012991606,114.25813127402,1.23089565168614,0.0001105447439914,3.95646190174896,3.23648804294829,167.757055506696,1.11330211002346e-05,"lineage2","dr_mutations_pyrazinamide","ASN",0,"MDR_4160","SRR6824580","lineage2.2.1","cn","China: Pingding County, Yangquan City, Shanxi Province","pnca_p.asp12asn","A","G","ASP","DA12","pnca_complex.pdb"
|
|
"D12N","L2","PZA","D","D12",12,"N",1,"Pre-XDR","DM","hydrophilic","hydrophilic","acidic","neutral","neg","polar",7.825,-1.928,0.018,1.58277,-2.236,0.09,79,85,-1.058,9,9,22,0.113989637305699,"helix",-1.4,5.01,0.000646830530401,17.0174957841484,17.0174574529133,17.0076332291246,19.306440114962,0,16,0,0,16,0,0,0,0,2,0,2,0,0,0,0,0,-7,0,-5,-2,0,0,0,0,-0.488348530901722,0.0153061224489795,0.0576479286708091,-0.381244671781756,0.0505617977528089,0.831578947368421,-0.871499176276771,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.124,-1.028,"9:9","147/150","C:D:T:G",2.83423972614077,0.0004057565735776,0.801467871651648,3.53631109416779,4.11022012991606,114.25813127402,1.23089565168614,0.0001105447439914,3.95646190174896,3.23648804294829,167.757055506696,1.11330211002346e-05,"lineage2","dr_mutations_pyrazinamide","ASN",0,"ERR2517033","ERR2517033","lineage2.2.1","gb","UK","pnca_p.asp12asn","A","G","ASP","DA12","pnca_complex.pdb"
|
|
"D12N","L2","PZA","D","D12",12,"N",1,"Pre-XDR","DM","hydrophilic","hydrophilic","acidic","neutral","neg","polar",7.825,-1.928,0.018,1.58277,-2.236,0.09,79,85,-1.058,9,9,22,0.113989637305699,"helix",-1.4,5.01,0.000646830530401,17.0174957841484,17.0174574529133,17.0076332291246,19.306440114962,0,16,0,0,16,0,0,0,0,2,0,2,0,0,0,0,0,-7,0,-5,-2,0,0,0,0,-0.488348530901722,0.0153061224489795,0.0576479286708091,-0.381244671781756,0.0505617977528089,0.831578947368421,-0.871499176276771,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.124,-1.028,"9:9","147/150","C:D:T:G",2.83423972614077,0.0004057565735776,0.801467871651648,3.53631109416779,4.11022012991606,114.25813127402,1.23089565168614,0.0001105447439914,3.95646190174896,3.23648804294829,167.757055506696,1.11330211002346e-05,"lineage2","dr_mutations_pyrazinamide","ASN",0,"ERR2516769","ERR2516769","lineage2.2.1","gb","UK","pnca_p.asp12asn","A","G","ASP","DA12","pnca_complex.pdb"
|
|
"D12Y","L4","PZA","D","D12",12,"Y",NA,"MDR","OM","hydrophilic","hydrophobic","acidic","neutral","neg","polar",7.825,-1.94,-0.794,4.93098,-1.092,-0.59,82,91,-1.058,9,9,22,0.113989637305699,"helix",-1.4,5.01,NA,NA,NA,NA,NA,-30,16,0,0,16,0,0,0,0,4,0,4,0,0,0,0,0,-7,0,-7,-2,0,0,0,-6,-0.491388044579534,-0.205167958656331,0.179597025036604,-0.18618925831202,-0.154450261780105,0.863157894736842,-0.871499176276771,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.124,-1.028,"9:9","147/150","C:D:T:G",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage4","other_mutations_pyrazinamide","TYR",0,"ERR047881","ERR047881","lineage4.3.3","gb","UK","pnca_p.asp12tyr","A","G","ASP","DA12","pnca_complex.pdb"
|
|
"F13C","L4","PZA","F","F13",13,"C",NA,"Pre-MDR","OM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",3.551,-0.485,-2.32,2.69734,-2.036,-2.68,79,85,-1.201,9,9,24,0.1,"helix",0.6,6.93,0.0001437401178668,1.2119588062211,4.59700131334268e-05,0,1.01056822389159e-25,42,4,0,0,4,0,0,0,0,0,0,-2,0,0,0,0,0,-7,0,-5,-2,-2,0,-2,0,-0.122847011144883,-0.599483204134367,0.098242994194305,-0.347144075021313,-0.701570680628272,0.831578947368421,-0.989291598023064,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","F",-9.98752126245058,0.942832958100734,139.277183325397,-0.0717096729269463,NA,144471.706314842,0.0834878586628579,1,0,0,25.8386585962163,0.999999999999746,"lineage4","other_mutations_pyrazinamide","CYS",0,"ERR1034975","ERR1034975","lineage4.3.2.1","za","South Africa","pnca_p.phe13cys","A","G","PHE","FA13","pnca_complex.pdb"
|
|
"F13C","L4","PZA","F","F13",13,"C",NA,"Pre-MDR","OM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",3.551,-0.485,-2.32,2.69734,-2.036,-2.68,79,85,-1.201,9,9,24,0.1,"helix",0.6,6.93,0.0001437401178668,1.2119588062211,4.59700131334268e-05,0,1.01056822389159e-25,42,4,0,0,4,0,0,0,0,0,0,-2,0,0,0,0,0,-7,0,-5,-2,-2,0,-2,0,-0.122847011144883,-0.599483204134367,0.098242994194305,-0.347144075021313,-0.701570680628272,0.831578947368421,-0.989291598023064,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","F",-9.98752126245058,0.942832958100734,139.277183325397,-0.0717096729269463,NA,144471.706314842,0.0834878586628579,1,0,0,25.8386585962163,0.999999999999746,"lineage4","other_mutations_pyrazinamide","CYS",0,"ERR1034989","ERR1034989","lineage4.3.2.1","za","South Africa","pnca_p.phe13cys","A","G","PHE","FA13","pnca_complex.pdb"
|
|
"F13C","L3","PZA","F","F13",13,"C",0,"MDR","OM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",3.551,-0.485,-2.32,2.69734,-2.036,-2.68,79,85,-1.201,9,9,24,0.1,"helix",0.6,6.93,0.0001437401178668,1.2119588062211,4.59700131334268e-05,0,1.01056822389159e-25,42,4,0,0,4,0,0,0,0,0,0,-2,0,0,0,0,0,-7,0,-5,-2,-2,0,-2,0,-0.122847011144883,-0.599483204134367,0.098242994194305,-0.347144075021313,-0.701570680628272,0.831578947368421,-0.989291598023064,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","F",-9.98752126245058,0.942832958100734,139.277183325397,-0.0717096729269463,NA,144471.706314842,0.0834878586628579,1,0,0,25.8386585962163,0.999999999999746,"lineage3","other_mutations_pyrazinamide","CYS",0,"ERR2510245","ERR2510245","lineage3","pk","Pakistan","pnca_p.phe13cys","A","G","PHE","FA13","pnca_complex.pdb"
|
|
"F13C","L4","PZA","F","F13",13,"C",0,"MDR","OM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",3.551,-0.485,-2.32,2.69734,-2.036,-2.68,79,85,-1.201,9,9,24,0.1,"helix",0.6,6.93,0.0001437401178668,1.2119588062211,4.59700131334268e-05,0,1.01056822389159e-25,42,4,0,0,4,0,0,0,0,0,0,-2,0,0,0,0,0,-7,0,-5,-2,-2,0,-2,0,-0.122847011144883,-0.599483204134367,0.098242994194305,-0.347144075021313,-0.701570680628272,0.831578947368421,-0.989291598023064,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","F",-9.98752126245058,0.942832958100734,139.277183325397,-0.0717096729269463,NA,144471.706314842,0.0834878586628579,1,0,0,25.8386585962163,0.999999999999746,"lineage4","other_mutations_pyrazinamide","CYS",0,"ERR1034993","ERR1034993","lineage4.3.2.1","za","South Africa","pnca_p.phe13cys","A","G","PHE","FA13","pnca_complex.pdb"
|
|
"F13I","L4","PZA","F","F13",13,"I",1,"MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",3.551,-0.45,-1.762,0.887245,-1.241,-2.3,83,91,-1.201,9,9,24,0.1,"helix",0.6,6.93,0.0002874802357337,14.5631313131313,14.5630810302277,14.5631012253236,5.81873994206135,12,8,0,0,8,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-3,-4,4,0,2,4,-0.113981762917933,-0.455297157622739,0.0323153941972188,-0.211594202898551,-0.602094240837696,0.873684210526316,-0.989291598023064,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","F",2.67848962960141,0.0202679102821363,1.15384949648317,2.3213509541454,1.86363317860665,294.488177945996,1.16325476548539,0.0174140488202037,1.75910024233227,1.16837785201846,760.989759542733,0.0158563003544608,"lineage4","dr_mutations_pyrazinamide","ILE",0,"ERR2864275","ERR2864275","lineage4.1.2.1","pt","Portugal","pnca_p.phe13ile","A","G","PHE","FA13","pnca_complex.pdb"
|
|
"F13I","L4","PZA","F","F13",13,"I",0,"MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",3.551,-0.45,-1.762,0.887245,-1.241,-2.3,83,91,-1.201,9,9,24,0.1,"helix",0.6,6.93,0.0002874802357337,14.5631313131313,14.5630810302277,14.5631012253236,5.81873994206135,12,8,0,0,8,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-3,-4,4,0,2,4,-0.113981762917933,-0.455297157622739,0.0323153941972188,-0.211594202898551,-0.602094240837696,0.873684210526316,-0.989291598023064,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","F",2.67848962960141,0.0202679102821363,1.15384949648317,2.3213509541454,1.86363317860665,294.488177945996,1.16325476548539,0.0174140488202037,1.75910024233227,1.16837785201846,760.989759542733,0.0158563003544608,"lineage4","dr_mutations_pyrazinamide","ILE",0,"ERR2864233","ERR2864233","lineage4.1.2.1","pt","Portugal","pnca_p.phe13ile","A","G","PHE","FA13","pnca_complex.pdb"
|
|
"F13I","L4","PZA","F","F13",13,"I",1,"MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",3.551,-0.45,-1.762,0.887245,-1.241,-2.3,83,91,-1.201,9,9,24,0.1,"helix",0.6,6.93,0.0002874802357337,14.5631313131313,14.5630810302277,14.5631012253236,5.81873994206135,12,8,0,0,8,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-3,-4,4,0,2,4,-0.113981762917933,-0.455297157622739,0.0323153941972188,-0.211594202898551,-0.602094240837696,0.873684210526316,-0.989291598023064,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","F",2.67848962960141,0.0202679102821363,1.15384949648317,2.3213509541454,1.86363317860665,294.488177945996,1.16325476548539,0.0174140488202037,1.75910024233227,1.16837785201846,760.989759542733,0.0158563003544608,"lineage4","dr_mutations_pyrazinamide","ILE",0,"ERR2864223","ERR2864223","lineage4.1.2.1","pt","Portugal","pnca_p.phe13ile","A","G","PHE","FA13","pnca_complex.pdb"
|
|
"F13I","L4","PZA","F","F13",13,"I",1,"MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",3.551,-0.45,-1.762,0.887245,-1.241,-2.3,83,91,-1.201,9,9,24,0.1,"helix",0.6,6.93,0.0002874802357337,14.5631313131313,14.5630810302277,14.5631012253236,5.81873994206135,12,8,0,0,8,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-3,-4,4,0,2,4,-0.113981762917933,-0.455297157622739,0.0323153941972188,-0.211594202898551,-0.602094240837696,0.873684210526316,-0.989291598023064,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","F",2.67848962960141,0.0202679102821363,1.15384949648317,2.3213509541454,1.86363317860665,294.488177945996,1.16325476548539,0.0174140488202037,1.75910024233227,1.16837785201846,760.989759542733,0.0158563003544608,"lineage4","dr_mutations_pyrazinamide","ILE",0,"ERR1034842","ERR1034842","lineage4.1.2.1","pt","Portugal","pnca_p.phe13ile","A","G","PHE","FA13","pnca_complex.pdb"
|
|
"F13L","L4","PZA","F","F13",13,"L",1,"XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",3.551,-0.427,-2.033,1.0968,-1.283,-2.06,84,91,-1.201,9,9,24,0.1,"helix",0.6,6.93,0.0005749604714675,34.0379426644182,34.0375872334388,34.0436365315203,23.2409378193551,8,6,0,0,6,0,0,0,0,0,0,0,0,0,0,0,0,-4,0,-2,-4,-4,0,-2,0,-0.108156028368794,-0.525322997416021,0.0399478434429155,-0.218755328218244,-0.539267015706806,0.884210526315789,-0.989291598023064,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","F",3.52746542085928,0.0009482725856346,1.06716956280854,3.3054404321426,6.05331233477459,636.464952476757,1.53196330239691,2.88610345466244e-05,4.53968810533409,4.36820226973726,1521.29182901896,1.42922316872435e-06,"lineage4","dr_mutations_pyrazinamide","LEU",0,"ERR1873518","ERR1873518","lineage4.1.1.3","za","South Africa","pnca_p.phe13leu","A","G","PHE","FA13","pnca_complex.pdb"
|
|
"F13L","L4","PZA","F","F13",13,"L",1,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",3.551,-0.427,-2.033,1.0968,-1.283,-2.06,84,91,-1.201,9,9,24,0.1,"helix",0.6,6.93,0.0005749604714675,34.0379426644182,34.0375872334388,34.0436365315203,23.2409378193551,8,6,0,0,6,0,0,0,0,0,0,0,0,0,0,0,0,-4,0,-2,-4,-4,0,-2,0,-0.108156028368794,-0.525322997416021,0.0399478434429155,-0.218755328218244,-0.539267015706806,0.884210526315789,-0.989291598023064,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","F",3.52746542085928,0.0009482725856346,1.06716956280854,3.3054404321426,6.05331233477459,636.464952476757,1.53196330239691,2.88610345466244e-05,4.53968810533409,4.36820226973726,1521.29182901896,1.42922316872435e-06,"lineage4","dr_mutations_pyrazinamide","LEU",0,"ERR2516289","ERR2516289","lineage4.6","be","Belgium","pnca_p.phe13leu","A","G","PHE","FA13","pnca_complex.pdb"
|
|
"F13L","L4","PZA","F","F13",13,"L",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",3.551,-0.427,-2.033,1.0968,-1.283,-2.06,84,91,-1.201,9,9,24,0.1,"helix",0.6,6.93,0.0005749604714675,34.0379426644182,34.0375872334388,34.0436365315203,23.2409378193551,8,6,0,0,6,0,0,0,0,0,0,0,0,0,0,0,0,-4,0,-2,-4,-4,0,-2,0,-0.108156028368794,-0.525322997416021,0.0399478434429155,-0.218755328218244,-0.539267015706806,0.884210526315789,-0.989291598023064,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","F",3.52746542085928,0.0009482725856346,1.06716956280854,3.3054404321426,6.05331233477459,636.464952476757,1.53196330239691,2.88610345466244e-05,4.53968810533409,4.36820226973726,1521.29182901896,1.42922316872435e-06,"lineage4","dr_mutations_pyrazinamide","LEU",0,"SAMN02414960","SRR1162819_SRR1165598_SRR1162876_SRR1165526","lineage4.3.4.1","se","Sweden","pnca_p.phe13leu","A","G","PHE","FA13","pnca_complex.pdb"
|
|
"F13L","L4","PZA","F","F13",13,"L",1,"XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",3.551,-0.427,-2.033,1.0968,-1.283,-2.06,84,91,-1.201,9,9,24,0.1,"helix",0.6,6.93,0.0005749604714675,34.0379426644182,34.0375872334388,34.0436365315203,23.2409378193551,8,6,0,0,6,0,0,0,0,0,0,0,0,0,0,0,0,-4,0,-2,-4,-4,0,-2,0,-0.108156028368794,-0.525322997416021,0.0399478434429155,-0.218755328218244,-0.539267015706806,0.884210526315789,-0.989291598023064,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","F",3.52746542085928,0.0009482725856346,1.06716956280854,3.3054404321426,6.05331233477459,636.464952476757,1.53196330239691,2.88610345466244e-05,4.53968810533409,4.36820226973726,1521.29182901896,1.42922316872435e-06,"lineage4","dr_mutations_pyrazinamide","LEU",0,"ERR1036294","ERR1036294","lineage4.3.4.2","pt","Portugal","pnca_p.phe13leu","A","G","PHE","FA13","pnca_complex.pdb"
|
|
"F13L","LBOV","PZA","F","F13",13,"L",1,"Other","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",3.551,-0.427,-2.033,1.0968,-1.283,-2.06,84,91,-1.201,9,9,24,0.1,"helix",0.6,6.93,0.0005749604714675,34.0379426644182,34.0375872334388,34.0436365315203,23.2409378193551,8,6,0,0,6,0,0,0,0,0,0,0,0,0,0,0,0,-4,0,-2,-4,-4,0,-2,0,-0.108156028368794,-0.525322997416021,0.0399478434429155,-0.218755328218244,-0.539267015706806,0.884210526315789,-0.989291598023064,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","F",3.52746542085928,0.0009482725856346,1.06716956280854,3.3054404321426,6.05331233477459,636.464952476757,1.53196330239691,2.88610345466244e-05,4.53968810533409,4.36820226973726,1521.29182901896,1.42922316872435e-06,"lineageBOV","dr_mutations_pyrazinamide","LEU",0,"ERR2517357","ERR2517357","lineageBOV","nl","Netherlands","pnca_p.phe13leu","A","G","PHE","FA13","pnca_complex.pdb"
|
|
"F13L","L4","PZA","F","F13",13,"L",1,"XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",3.551,-0.427,-2.033,1.0968,-1.283,-2.06,84,91,-1.201,9,9,24,0.1,"helix",0.6,6.93,0.0005749604714675,34.0379426644182,34.0375872334388,34.0436365315203,23.2409378193551,8,6,0,0,6,0,0,0,0,0,0,0,0,0,0,0,0,-4,0,-2,-4,-4,0,-2,0,-0.108156028368794,-0.525322997416021,0.0399478434429155,-0.218755328218244,-0.539267015706806,0.884210526315789,-0.989291598023064,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","F",3.52746542085928,0.0009482725856346,1.06716956280854,3.3054404321426,6.05331233477459,636.464952476757,1.53196330239691,2.88610345466244e-05,4.53968810533409,4.36820226973726,1521.29182901896,1.42922316872435e-06,"lineage4","dr_mutations_pyrazinamide","LEU",0,"ERR1034852","ERR1034852","lineage4.3.4.2","pt","Portugal","pnca_p.phe13leu","A","G","PHE","FA13","pnca_complex.pdb"
|
|
"F13L","LBOV","PZA","F","F13",13,"L",1,"Other","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",3.551,-0.427,-2.033,1.0968,-1.283,-2.06,84,91,-1.201,9,9,24,0.1,"helix",0.6,6.93,0.0005749604714675,34.0379426644182,34.0375872334388,34.0436365315203,23.2409378193551,8,6,0,0,6,0,0,0,0,0,0,0,0,0,0,0,0,-4,0,-2,-4,-4,0,-2,0,-0.108156028368794,-0.525322997416021,0.0399478434429155,-0.218755328218244,-0.539267015706806,0.884210526315789,-0.989291598023064,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","F",3.52746542085928,0.0009482725856346,1.06716956280854,3.3054404321426,6.05331233477459,636.464952476757,1.53196330239691,2.88610345466244e-05,4.53968810533409,4.36820226973726,1521.29182901896,1.42922316872435e-06,"lineageBOV","dr_mutations_pyrazinamide","LEU",0,"ERR2517151","ERR2517151","lineageBOV","nl","Netherlands","pnca_p.phe13leu","A","G","PHE","FA13","pnca_complex.pdb"
|
|
"F13L","LBOV","PZA","F","F13",13,"L",NA,"Other","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",3.551,-0.427,-2.033,1.0968,-1.283,-2.06,84,91,-1.201,9,9,24,0.1,"helix",0.6,6.93,0.0005749604714675,34.0379426644182,34.0375872334388,34.0436365315203,23.2409378193551,8,6,0,0,6,0,0,0,0,0,0,0,0,0,0,0,0,-4,0,-2,-4,-4,0,-2,0,-0.108156028368794,-0.525322997416021,0.0399478434429155,-0.218755328218244,-0.539267015706806,0.884210526315789,-0.989291598023064,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","F",3.52746542085928,0.0009482725856346,1.06716956280854,3.3054404321426,6.05331233477459,636.464952476757,1.53196330239691,2.88610345466244e-05,4.53968810533409,4.36820226973726,1521.29182901896,1.42922316872435e-06,"lineageBOV","dr_mutations_pyrazinamide","LEU",0,"ERR2446525","ERR2446525","lineageBOV","nl","Netherlands","pnca_p.phe13leu","A","G","PHE","FA13","pnca_complex.pdb"
|
|
"F13L","L4","PZA","F","F13",13,"L",0,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",3.551,-0.427,-2.033,1.0968,-1.283,-2.06,84,91,-1.201,9,9,24,0.1,"helix",0.6,6.93,0.0005749604714675,34.0379426644182,34.0375872334388,34.0436365315203,23.2409378193551,8,6,0,0,6,0,0,0,0,0,0,0,0,0,0,0,0,-4,0,-2,-4,-4,0,-2,0,-0.108156028368794,-0.525322997416021,0.0399478434429155,-0.218755328218244,-0.539267015706806,0.884210526315789,-0.989291598023064,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","F",3.52746542085928,0.0009482725856346,1.06716956280854,3.3054404321426,6.05331233477459,636.464952476757,1.53196330239691,2.88610345466244e-05,4.53968810533409,4.36820226973726,1521.29182901896,1.42922316872435e-06,"lineage4","dr_mutations_pyrazinamide","LEU",0,"ERR2516969","ERR2516969","lineage4.6","gb","UK","pnca_p.phe13leu","A","G","PHE","FA13","pnca_complex.pdb"
|
|
"F13L","L4","PZA","F","F13",13,"L",1,"XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",3.551,-0.427,-2.033,1.0968,-1.283,-2.06,84,91,-1.201,9,9,24,0.1,"helix",0.6,6.93,0.0005749604714675,34.0379426644182,34.0375872334388,34.0436365315203,23.2409378193551,8,6,0,0,6,0,0,0,0,0,0,0,0,0,0,0,0,-4,0,-2,-4,-4,0,-2,0,-0.108156028368794,-0.525322997416021,0.0399478434429155,-0.218755328218244,-0.539267015706806,0.884210526315789,-0.989291598023064,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","F",3.52746542085928,0.0009482725856346,1.06716956280854,3.3054404321426,6.05331233477459,636.464952476757,1.53196330239691,2.88610345466244e-05,4.53968810533409,4.36820226973726,1521.29182901896,1.42922316872435e-06,"lineage4","dr_mutations_pyrazinamide","LEU",0,"ERR1036296","ERR1036296","lineage4.3.4.2","pt","Portugal","pnca_p.phe13leu","A","G","PHE","FA13","pnca_complex.pdb"
|
|
"F13L","L4","PZA","F","F13",13,"L",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",3.551,-0.427,-2.033,1.0968,-1.283,-2.06,84,91,-1.201,9,9,24,0.1,"helix",0.6,6.93,0.0005749604714675,34.0379426644182,34.0375872334388,34.0436365315203,23.2409378193551,8,6,0,0,6,0,0,0,0,0,0,0,0,0,0,0,0,-4,0,-2,-4,-4,0,-2,0,-0.108156028368794,-0.525322997416021,0.0399478434429155,-0.218755328218244,-0.539267015706806,0.884210526315789,-0.989291598023064,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","F",3.52746542085928,0.0009482725856346,1.06716956280854,3.3054404321426,6.05331233477459,636.464952476757,1.53196330239691,2.88610345466244e-05,4.53968810533409,4.36820226973726,1521.29182901896,1.42922316872435e-06,"lineage4","dr_mutations_pyrazinamide","LEU",0,"SAMN02414897","SRR1166815_SRR1146314_SRR1162834_SRR1144726","lineage4.3.4.1","se","Sweden","pnca_p.phe13leu","A","G","PHE","FA13","pnca_complex.pdb"
|
|
"F13L","L4","PZA","F","F13",13,"L",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",3.551,-0.427,-2.033,1.0968,-1.283,-2.06,84,91,-1.201,9,9,24,0.1,"helix",0.6,6.93,0.0005749604714675,34.0379426644182,34.0375872334388,34.0436365315203,23.2409378193551,8,6,0,0,6,0,0,0,0,0,0,0,0,0,0,0,0,-4,0,-2,-4,-4,0,-2,0,-0.108156028368794,-0.525322997416021,0.0399478434429155,-0.218755328218244,-0.539267015706806,0.884210526315789,-0.989291598023064,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","F",3.52746542085928,0.0009482725856346,1.06716956280854,3.3054404321426,6.05331233477459,636.464952476757,1.53196330239691,2.88610345466244e-05,4.53968810533409,4.36820226973726,1521.29182901896,1.42922316872435e-06,"lineage4","dr_mutations_pyrazinamide","LEU",0,"SAMN02414892","SRR1162850_SRR1144795_SRR1146415_SRR1166936","lineage4.3.4.1","se","Sweden","pnca_p.phe13leu","A","G","PHE","FA13","pnca_complex.pdb"
|
|
"F13S","L2","PZA","F","F13",13,"S",0,"XDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",3.551,0.218,-3.104,2.59174,-2.032,-3.54,88,91,-1.201,9,9,24,0.1,"helix",0.6,6.93,0.0002874802357337,1.61648444070648,1.61648999729673,1.61641362774286,5.75148528770432e-25,44,6,0,0,6,0,0,0,0,0,0,-2,0,0,0,0,0,-9,0,-5,-4,-2,0,2,6,0.0977578475336322,-0.802067183462532,0.0943968123310922,-0.346462063086104,-0.926701570680628,0.926315789473684,-0.989291598023064,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","F",0.480257130287146,0.677247786834331,1.1538493489906,0.416221693678883,0.0799389646160496,12.6318165284589,0.208571528713835,0.527693668101443,0.277618116975238,0.0307788891197694,20.1401594005,0.999999999999395,"lineage2","dr_mutations_pyrazinamide","SER",0,"0218N-sc-2011-09-07T13:18:52Z-1276431,ERR067584","ERR067584","lineage2.2.1","ru","Russia,Samara","pnca_p.phe13ser","A","G","PHE","FA13","pnca_complex.pdb"
|
|
"F13S","L4","PZA","F","F13",13,"S",0,"MDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",3.551,0.218,-3.104,2.59174,-2.032,-3.54,88,91,-1.201,9,9,24,0.1,"helix",0.6,6.93,0.0002874802357337,1.61648444070648,1.61648999729673,1.61641362774286,5.75148528770432e-25,44,6,0,0,6,0,0,0,0,0,0,-2,0,0,0,0,0,-9,0,-5,-4,-2,0,2,6,0.0977578475336322,-0.802067183462532,0.0943968123310922,-0.346462063086104,-0.926701570680628,0.926315789473684,-0.989291598023064,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","F",0.480257130287146,0.677247786834331,1.1538493489906,0.416221693678883,0.0799389646160496,12.6318165284589,0.208571528713835,0.527693668101443,0.277618116975238,0.0307788891197694,20.1401594005,0.999999999999395,"lineage4","dr_mutations_pyrazinamide","SER",0,"ERR2517062","ERR2517062","lineage4.3.4.2.1","gb","UK","pnca_p.phe13ser","A","G","PHE","FA13","pnca_complex.pdb"
|
|
"F13S","L2","PZA","F","F13",13,"S",NA,"Pre-MDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",3.551,0.218,-3.104,2.59174,-2.032,-3.54,88,91,-1.201,9,9,24,0.1,"helix",0.6,6.93,0.0002874802357337,1.61648444070648,1.61648999729673,1.61641362774286,5.75148528770432e-25,44,6,0,0,6,0,0,0,0,0,0,-2,0,0,0,0,0,-9,0,-5,-4,-2,0,2,6,0.0977578475336322,-0.802067183462532,0.0943968123310922,-0.346462063086104,-0.926701570680628,0.926315789473684,-0.989291598023064,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","F",0.480257130287146,0.677247786834331,1.1538493489906,0.416221693678883,0.0799389646160496,12.6318165284589,0.208571528713835,0.527693668101443,0.277618116975238,0.0307788891197694,20.1401594005,0.999999999999395,"lineage2","dr_mutations_pyrazinamide","SER",0,"SRR5073641","SRR5073641","lineage2.2.1.1","vn","Vietnam","pnca_p.phe13ser","A","G","PHE","FA13","pnca_complex.pdb"
|
|
"F13S","L2","PZA","F","F13",13,"S",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",3.551,0.218,-3.104,2.59174,-2.032,-3.54,88,91,-1.201,9,9,24,0.1,"helix",0.6,6.93,0.0002874802357337,1.61648444070648,1.61648999729673,1.61641362774286,5.75148528770432e-25,44,6,0,0,6,0,0,0,0,0,0,-2,0,0,0,0,0,-9,0,-5,-4,-2,0,2,6,0.0977578475336322,-0.802067183462532,0.0943968123310922,-0.346462063086104,-0.926701570680628,0.926315789473684,-0.989291598023064,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","F",0.480257130287146,0.677247786834331,1.1538493489906,0.416221693678883,0.0799389646160496,12.6318165284589,0.208571528713835,0.527693668101443,0.277618116975238,0.0307788891197694,20.1401594005,0.999999999999395,"lineage2","dr_mutations_pyrazinamide","SER",0,"SRR5067458","SRR5067458","lineage2.1","vn","Vietnam","pnca_p.phe13ser","A","G","PHE","FA13","pnca_complex.pdb"
|
|
"F13S","L4","PZA","F","F13",13,"S",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",3.551,0.218,-3.104,2.59174,-2.032,-3.54,88,91,-1.201,9,9,24,0.1,"helix",0.6,6.93,0.0002874802357337,1.61648444070648,1.61648999729673,1.61641362774286,5.75148528770432e-25,44,6,0,0,6,0,0,0,0,0,0,-2,0,0,0,0,0,-9,0,-5,-4,-2,0,2,6,0.0977578475336322,-0.802067183462532,0.0943968123310922,-0.346462063086104,-0.926701570680628,0.926315789473684,-0.989291598023064,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","F",0.480257130287146,0.677247786834331,1.1538493489906,0.416221693678883,0.0799389646160496,12.6318165284589,0.208571528713835,0.527693668101443,0.277618116975238,0.0307788891197694,20.1401594005,0.999999999999395,"lineage4","dr_mutations_pyrazinamide","SER",0,"SAMN02584647","SRR1169152_SRR1166115","lineage4.2.1","md","Moldova","pnca_p.phe13ser","A","G","PHE","FA13","pnca_complex.pdb"
|
|
"F13S","L4","PZA","F","F13",13,"S",0,"MDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",3.551,0.218,-3.104,2.59174,-2.032,-3.54,88,91,-1.201,9,9,24,0.1,"helix",0.6,6.93,0.0002874802357337,1.61648444070648,1.61648999729673,1.61641362774286,5.75148528770432e-25,44,6,0,0,6,0,0,0,0,0,0,-2,0,0,0,0,0,-9,0,-5,-4,-2,0,2,6,0.0977578475336322,-0.802067183462532,0.0943968123310922,-0.346462063086104,-0.926701570680628,0.926315789473684,-0.989291598023064,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","F",0.480257130287146,0.677247786834331,1.1538493489906,0.416221693678883,0.0799389646160496,12.6318165284589,0.208571528713835,0.527693668101443,0.277618116975238,0.0307788891197694,20.1401594005,0.999999999999395,"lineage4","dr_mutations_pyrazinamide","SER",0,"ERR2516808","ERR2516808","lineage4.3.4.2.1","gb","UK","pnca_p.phe13ser","A","G","PHE","FA13","pnca_complex.pdb"
|
|
"F13S","L4","PZA","F","F13",13,"S",1,"Pre-XDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",3.551,0.218,-3.104,2.59174,-2.032,-3.54,88,91,-1.201,9,9,24,0.1,"helix",0.6,6.93,0.0002874802357337,1.61648444070648,1.61648999729673,1.61641362774286,5.75148528770432e-25,44,6,0,0,6,0,0,0,0,0,0,-2,0,0,0,0,0,-9,0,-5,-4,-2,0,2,6,0.0977578475336322,-0.802067183462532,0.0943968123310922,-0.346462063086104,-0.926701570680628,0.926315789473684,-0.989291598023064,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","F",0.480257130287146,0.677247786834331,1.1538493489906,0.416221693678883,0.0799389646160496,12.6318165284589,0.208571528713835,0.527693668101443,0.277618116975238,0.0307788891197694,20.1401594005,0.999999999999395,"lineage4","dr_mutations_pyrazinamide","SER",0,"ERS457692","ERR551919_ERR551918","lineage4.8","uz","Nukus","pnca_p.phe13ser","A","G","PHE","FA13","pnca_complex.pdb"
|
|
"F13S","L4","PZA","F","F13",13,"S",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",3.551,0.218,-3.104,2.59174,-2.032,-3.54,88,91,-1.201,9,9,24,0.1,"helix",0.6,6.93,0.0002874802357337,1.61648444070648,1.61648999729673,1.61641362774286,5.75148528770432e-25,44,6,0,0,6,0,0,0,0,0,0,-2,0,0,0,0,0,-9,0,-5,-4,-2,0,2,6,0.0977578475336322,-0.802067183462532,0.0943968123310922,-0.346462063086104,-0.926701570680628,0.926315789473684,-0.989291598023064,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","F",0.480257130287146,0.677247786834331,1.1538493489906,0.416221693678883,0.0799389646160496,12.6318165284589,0.208571528713835,0.527693668101443,0.277618116975238,0.0307788891197694,20.1401594005,0.999999999999395,"lineage4","dr_mutations_pyrazinamide","SER",0,"ERR2515872","ERR2515872","lineage4.1.1.3","za","South Africa","pnca_p.phe13ser","A","G","PHE","FA13","pnca_complex.pdb"
|
|
"F13V","L3","PZA","F","F13",13,"V",0,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",3.551,-0.562,-2.57,1.40193,-2.51,-2.34,84,91,-1.201,9,9,24,0.1,"helix",0.6,6.93,0.0001437401178668,1.2119588062211,4.59700131334268e-05,0,1.01056822389159e-25,44,8,0,0,8,0,0,0,0,2,0,2,0,0,0,0,0,-1,0,-1,0,0,0,-4,0,-0.142350557244174,-0.664082687338501,0.051061342230057,-0.427962489343563,-0.612565445026178,0.884210526315789,-0.989291598023064,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","F",-9.98752126245058,0.942832958100734,139.277183325397,-0.0717096729269463,NA,144471.706314842,0.0834878586628579,1,0,0,25.8386585962163,0.999999999999746,"lineage3","other_mutations_pyrazinamide","VAL",0,"ERR2510280","ERR2510280","lineage3","pk","Pakistan","pnca_p.phe13val","A","G","PHE","FA13","pnca_complex.pdb"
|
|
"F13V","L3","PZA","F","F13",13,"V",0,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",3.551,-0.562,-2.57,1.40193,-2.51,-2.34,84,91,-1.201,9,9,24,0.1,"helix",0.6,6.93,0.0001437401178668,1.2119588062211,4.59700131334268e-05,0,1.01056822389159e-25,44,8,0,0,8,0,0,0,0,2,0,2,0,0,0,0,0,-1,0,-1,0,0,0,-4,0,-0.142350557244174,-0.664082687338501,0.051061342230057,-0.427962489343563,-0.612565445026178,0.884210526315789,-0.989291598023064,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","147/150","F",-9.98752126245058,0.942832958100734,139.277183325397,-0.0717096729269463,NA,144471.706314842,0.0834878586628579,1,0,0,25.8386585962163,0.999999999999746,"lineage3","other_mutations_pyrazinamide","VAL",0,"ERR2510568","ERR2510568","lineage3","pk","Pakistan","pnca_p.phe13val","A","G","PHE","FA13","pnca_complex.pdb"
|
|
"C14G","L4","PZA","C","C14",14,"G",0,"Pre-XDR","DM","hydrophobic","hydrophobic","neutral","neutral","non-polar","non-polar",8.493,-1.214,-0.534,1.40101,-2.618,1.21,82,91,0.013,5,5,1,0.0059880239520958,"loop",0.6,5.76,0.0009343107661348,4.1639877189814,4.16398768969361,4.16339464867528,5.83418569155344,10,0,0,0,0,0,0,0,0,0,0,2,-2,0,0,0,0,4,0,4,2,4,0,13,15,-0.307497467071935,-0.137984496124031,0.0510278338274609,-0.446376811594203,0.679775280898876,0.863157894736842,0.00416666666666667,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.244,0.225,"6:4","147/150","L:V:C:I:M:A:T",1.42647319438274,0.0104102993024226,0.556804076010637,2.56189431047824,1.33944091330526,12.5461379903288,0.619509439957981,0.0142886927095374,1.84500750353971,1.15481122214044,14.4829286214949,0.0157176829434794,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR2510823","ERR2510823","lineage4.8","it","Italy","pnca_p.cys14gly","A","S","CYS","CA14","pnca_complex.pdb"
|
|
"C14G","L4","PZA","C","C14",14,"G",1,"Pre-XDR","DM","hydrophobic","hydrophobic","neutral","neutral","non-polar","non-polar",8.493,-1.214,-0.534,1.40101,-2.618,1.21,82,91,0.013,5,5,1,0.0059880239520958,"loop",0.6,5.76,0.0009343107661348,4.1639877189814,4.16398768969361,4.16339464867528,5.83418569155344,10,0,0,0,0,0,0,0,0,0,0,2,-2,0,0,0,0,4,0,4,2,4,0,13,15,-0.307497467071935,-0.137984496124031,0.0510278338274609,-0.446376811594203,0.679775280898876,0.863157894736842,0.00416666666666667,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.244,0.225,"6:4","147/150","L:V:C:I:M:A:T",1.42647319438274,0.0104102993024226,0.556804076010637,2.56189431047824,1.33944091330526,12.5461379903288,0.619509439957981,0.0142886927095374,1.84500750353971,1.15481122214044,14.4829286214949,0.0157176829434794,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR2516281","ERR2516281","lineage4.8","be","Belgium","pnca_p.cys14gly","A","S","CYS","CA14","pnca_complex.pdb"
|
|
"C14G","L2","PZA","C","C14",14,"G",1,"MDR","DM","hydrophobic","hydrophobic","neutral","neutral","non-polar","non-polar",8.493,-1.214,-0.534,1.40101,-2.618,1.21,82,91,0.013,5,5,1,0.0059880239520958,"loop",0.6,5.76,0.0009343107661348,4.1639877189814,4.16398768969361,4.16339464867528,5.83418569155344,10,0,0,0,0,0,0,0,0,0,0,2,-2,0,0,0,0,4,0,4,2,4,0,13,15,-0.307497467071935,-0.137984496124031,0.0510278338274609,-0.446376811594203,0.679775280898876,0.863157894736842,0.00416666666666667,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.244,0.225,"6:4","147/150","L:V:C:I:M:A:T",1.42647319438274,0.0104102993024226,0.556804076010637,2.56189431047824,1.33944091330526,12.5461379903288,0.619509439957981,0.0142886927095374,1.84500750353971,1.15481122214044,14.4829286214949,0.0157176829434794,"lineage2","dr_mutations_pyrazinamide","GLY",0,"ERR1034717","ERR1034717","lineage2.2.1","pe","Peru","pnca_p.cys14gly","A","S","CYS","CA14","pnca_complex.pdb"
|
|
"C14G","L4","PZA","C","C14",14,"G",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","neutral","neutral","non-polar","non-polar",8.493,-1.214,-0.534,1.40101,-2.618,1.21,82,91,0.013,5,5,1,0.0059880239520958,"loop",0.6,5.76,0.0009343107661348,4.1639877189814,4.16398768969361,4.16339464867528,5.83418569155344,10,0,0,0,0,0,0,0,0,0,0,2,-2,0,0,0,0,4,0,4,2,4,0,13,15,-0.307497467071935,-0.137984496124031,0.0510278338274609,-0.446376811594203,0.679775280898876,0.863157894736842,0.00416666666666667,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.244,0.225,"6:4","147/150","L:V:C:I:M:A:T",1.42647319438274,0.0104102993024226,0.556804076010637,2.56189431047824,1.33944091330526,12.5461379903288,0.619509439957981,0.0142886927095374,1.84500750353971,1.15481122214044,14.4829286214949,0.0157176829434794,"lineage4","dr_mutations_pyrazinamide","GLY",0,"SAMN02567712","SRR1166220","lineage4.8","ro","Romania","pnca_p.cys14gly","A","S","CYS","CA14","pnca_complex.pdb"
|
|
"C14G","L4","PZA","C","C14",14,"G",1,"XDR","DM","hydrophobic","hydrophobic","neutral","neutral","non-polar","non-polar",8.493,-1.214,-0.534,1.40101,-2.618,1.21,82,91,0.013,5,5,1,0.0059880239520958,"loop",0.6,5.76,0.0009343107661348,4.1639877189814,4.16398768969361,4.16339464867528,5.83418569155344,10,0,0,0,0,0,0,0,0,0,0,2,-2,0,0,0,0,4,0,4,2,4,0,13,15,-0.307497467071935,-0.137984496124031,0.0510278338274609,-0.446376811594203,0.679775280898876,0.863157894736842,0.00416666666666667,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.244,0.225,"6:4","147/150","L:V:C:I:M:A:T",1.42647319438274,0.0104102993024226,0.556804076010637,2.56189431047824,1.33944091330526,12.5461379903288,0.619509439957981,0.0142886927095374,1.84500750353971,1.15481122214044,14.4829286214949,0.0157176829434794,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR2516405","ERR2516405","lineage4.1.2.1","pe","Peru","pnca_p.cys14gly","A","S","CYS","CA14","pnca_complex.pdb"
|
|
"C14G","L4","PZA","C","C14",14,"G",NA,"Pre-MDR","DM","hydrophobic","hydrophobic","neutral","neutral","non-polar","non-polar",8.493,-1.214,-0.534,1.40101,-2.618,1.21,82,91,0.013,5,5,1,0.0059880239520958,"loop",0.6,5.76,0.0009343107661348,4.1639877189814,4.16398768969361,4.16339464867528,5.83418569155344,10,0,0,0,0,0,0,0,0,0,0,2,-2,0,0,0,0,4,0,4,2,4,0,13,15,-0.307497467071935,-0.137984496124031,0.0510278338274609,-0.446376811594203,0.679775280898876,0.863157894736842,0.00416666666666667,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.244,0.225,"6:4","147/150","L:V:C:I:M:A:T",1.42647319438274,0.0104102993024226,0.556804076010637,2.56189431047824,1.33944091330526,12.5461379903288,0.619509439957981,0.0142886927095374,1.84500750353971,1.15481122214044,14.4829286214949,0.0157176829434794,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR1199093","ERR1199093","lineage4.6.1.2","cd","Democratic Republic of the Congo","pnca_p.cys14gly","A","S","CYS","CA14","pnca_complex.pdb"
|
|
"C14G","L4","PZA","C","C14",14,"G",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","neutral","neutral","non-polar","non-polar",8.493,-1.214,-0.534,1.40101,-2.618,1.21,82,91,0.013,5,5,1,0.0059880239520958,"loop",0.6,5.76,0.0009343107661348,4.1639877189814,4.16398768969361,4.16339464867528,5.83418569155344,10,0,0,0,0,0,0,0,0,0,0,2,-2,0,0,0,0,4,0,4,2,4,0,13,15,-0.307497467071935,-0.137984496124031,0.0510278338274609,-0.446376811594203,0.679775280898876,0.863157894736842,0.00416666666666667,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.244,0.225,"6:4","147/150","L:V:C:I:M:A:T",1.42647319438274,0.0104102993024226,0.556804076010637,2.56189431047824,1.33944091330526,12.5461379903288,0.619509439957981,0.0142886927095374,1.84500750353971,1.15481122214044,14.4829286214949,0.0157176829434794,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR2516282","ERR2516282","lineage4.8","be","Belgium","pnca_p.cys14gly","A","S","CYS","CA14","pnca_complex.pdb"
|
|
"C14G","L4","PZA","C","C14",14,"G",1,"XDR","DM","hydrophobic","hydrophobic","neutral","neutral","non-polar","non-polar",8.493,-1.214,-0.534,1.40101,-2.618,1.21,82,91,0.013,5,5,1,0.0059880239520958,"loop",0.6,5.76,0.0009343107661348,4.1639877189814,4.16398768969361,4.16339464867528,5.83418569155344,10,0,0,0,0,0,0,0,0,0,0,2,-2,0,0,0,0,4,0,4,2,4,0,13,15,-0.307497467071935,-0.137984496124031,0.0510278338274609,-0.446376811594203,0.679775280898876,0.863157894736842,0.00416666666666667,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.244,0.225,"6:4","147/150","L:V:C:I:M:A:T",1.42647319438274,0.0104102993024226,0.556804076010637,2.56189431047824,1.33944091330526,12.5461379903288,0.619509439957981,0.0142886927095374,1.84500750353971,1.15481122214044,14.4829286214949,0.0157176829434794,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR2864280","ERR2864280","lineage4.3.4.2","pt","Portugal","pnca_p.cys14gly","A","S","CYS","CA14","pnca_complex.pdb"
|
|
"C14G","L4","PZA","C","C14",14,"G",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","neutral","neutral","non-polar","non-polar",8.493,-1.214,-0.534,1.40101,-2.618,1.21,82,91,0.013,5,5,1,0.0059880239520958,"loop",0.6,5.76,0.0009343107661348,4.1639877189814,4.16398768969361,4.16339464867528,5.83418569155344,10,0,0,0,0,0,0,0,0,0,0,2,-2,0,0,0,0,4,0,4,2,4,0,13,15,-0.307497467071935,-0.137984496124031,0.0510278338274609,-0.446376811594203,0.679775280898876,0.863157894736842,0.00416666666666667,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.244,0.225,"6:4","147/150","L:V:C:I:M:A:T",1.42647319438274,0.0104102993024226,0.556804076010637,2.56189431047824,1.33944091330526,12.5461379903288,0.619509439957981,0.0142886927095374,1.84500750353971,1.15481122214044,14.4829286214949,0.0157176829434794,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR2510824","ERR2510824","lineage4.8","it","Italy","pnca_p.cys14gly","A","S","CYS","CA14","pnca_complex.pdb"
|
|
"C14G","L4","PZA","C","C14",14,"G",1,"Pre-XDR","DM","hydrophobic","hydrophobic","neutral","neutral","non-polar","non-polar",8.493,-1.214,-0.534,1.40101,-2.618,1.21,82,91,0.013,5,5,1,0.0059880239520958,"loop",0.6,5.76,0.0009343107661348,4.1639877189814,4.16398768969361,4.16339464867528,5.83418569155344,10,0,0,0,0,0,0,0,0,0,0,2,-2,0,0,0,0,4,0,4,2,4,0,13,15,-0.307497467071935,-0.137984496124031,0.0510278338274609,-0.446376811594203,0.679775280898876,0.863157894736842,0.00416666666666667,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.244,0.225,"6:4","147/150","L:V:C:I:M:A:T",1.42647319438274,0.0104102993024226,0.556804076010637,2.56189431047824,1.33944091330526,12.5461379903288,0.619509439957981,0.0142886927095374,1.84500750353971,1.15481122214044,14.4829286214949,0.0157176829434794,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR2516167","ERR2516167","lineage4.8","be","Belgium","pnca_p.cys14gly","A","S","CYS","CA14","pnca_complex.pdb"
|
|
"C14G","L4","PZA","C","C14",14,"G",0,"XDR","DM","hydrophobic","hydrophobic","neutral","neutral","non-polar","non-polar",8.493,-1.214,-0.534,1.40101,-2.618,1.21,82,91,0.013,5,5,1,0.0059880239520958,"loop",0.6,5.76,0.0009343107661348,4.1639877189814,4.16398768969361,4.16339464867528,5.83418569155344,10,0,0,0,0,0,0,0,0,0,0,2,-2,0,0,0,0,4,0,4,2,4,0,13,15,-0.307497467071935,-0.137984496124031,0.0510278338274609,-0.446376811594203,0.679775280898876,0.863157894736842,0.00416666666666667,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.244,0.225,"6:4","147/150","L:V:C:I:M:A:T",1.42647319438274,0.0104102993024226,0.556804076010637,2.56189431047824,1.33944091330526,12.5461379903288,0.619509439957981,0.0142886927095374,1.84500750353971,1.15481122214044,14.4829286214949,0.0157176829434794,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR2516698","ERR2516698","lineage4.1.2.1","pe","Peru","pnca_p.cys14gly","A","S","CYS","CA14","pnca_complex.pdb"
|
|
"C14G","L4","PZA","C","C14",14,"G",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","neutral","neutral","non-polar","non-polar",8.493,-1.214,-0.534,1.40101,-2.618,1.21,82,91,0.013,5,5,1,0.0059880239520958,"loop",0.6,5.76,0.0009343107661348,4.1639877189814,4.16398768969361,4.16339464867528,5.83418569155344,10,0,0,0,0,0,0,0,0,0,0,2,-2,0,0,0,0,4,0,4,2,4,0,13,15,-0.307497467071935,-0.137984496124031,0.0510278338274609,-0.446376811594203,0.679775280898876,0.863157894736842,0.00416666666666667,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.244,0.225,"6:4","147/150","L:V:C:I:M:A:T",1.42647319438274,0.0104102993024226,0.556804076010637,2.56189431047824,1.33944091330526,12.5461379903288,0.619509439957981,0.0142886927095374,1.84500750353971,1.15481122214044,14.4829286214949,0.0157176829434794,"lineage4","dr_mutations_pyrazinamide","GLY",0,"SAMN02584616","SRR1169018_SRR1166146","lineage4.2.1","md","Moldova","pnca_p.cys14gly","A","S","CYS","CA14","pnca_complex.pdb"
|
|
"C14G","L4","PZA","C","C14",14,"G",NA,"MDR","DM","hydrophobic","hydrophobic","neutral","neutral","non-polar","non-polar",8.493,-1.214,-0.534,1.40101,-2.618,1.21,82,91,0.013,5,5,1,0.0059880239520958,"loop",0.6,5.76,0.0009343107661348,4.1639877189814,4.16398768969361,4.16339464867528,5.83418569155344,10,0,0,0,0,0,0,0,0,0,0,2,-2,0,0,0,0,4,0,4,2,4,0,13,15,-0.307497467071935,-0.137984496124031,0.0510278338274609,-0.446376811594203,0.679775280898876,0.863157894736842,0.00416666666666667,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.244,0.225,"6:4","147/150","L:V:C:I:M:A:T",1.42647319438274,0.0104102993024226,0.556804076010637,2.56189431047824,1.33944091330526,12.5461379903288,0.619509439957981,0.0142886927095374,1.84500750353971,1.15481122214044,14.4829286214949,0.0157176829434794,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR2706915","ERR2706915","lineage4.6.1.2","cd","Democratic Republic of Congo","pnca_p.cys14gly","A","S","CYS","CA14","pnca_complex.pdb"
|
|
"C14G","L4","PZA","C","C14",14,"G",0,"Pre-XDR","DM","hydrophobic","hydrophobic","neutral","neutral","non-polar","non-polar",8.493,-1.214,-0.534,1.40101,-2.618,1.21,82,91,0.013,5,5,1,0.0059880239520958,"loop",0.6,5.76,0.0009343107661348,4.1639877189814,4.16398768969361,4.16339464867528,5.83418569155344,10,0,0,0,0,0,0,0,0,0,0,2,-2,0,0,0,0,4,0,4,2,4,0,13,15,-0.307497467071935,-0.137984496124031,0.0510278338274609,-0.446376811594203,0.679775280898876,0.863157894736842,0.00416666666666667,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.244,0.225,"6:4","147/150","L:V:C:I:M:A:T",1.42647319438274,0.0104102993024226,0.556804076010637,2.56189431047824,1.33944091330526,12.5461379903288,0.619509439957981,0.0142886927095374,1.84500750353971,1.15481122214044,14.4829286214949,0.0157176829434794,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR2510725","ERR2510725","lineage4.8","it","Italy","pnca_p.cys14gly","A","S","CYS","CA14","pnca_complex.pdb"
|
|
"C14G","L2","PZA","C","C14",14,"G",NA,"XDR","DM","hydrophobic","hydrophobic","neutral","neutral","non-polar","non-polar",8.493,-1.214,-0.534,1.40101,-2.618,1.21,82,91,0.013,5,5,1,0.0059880239520958,"loop",0.6,5.76,0.0009343107661348,4.1639877189814,4.16398768969361,4.16339464867528,5.83418569155344,10,0,0,0,0,0,0,0,0,0,0,2,-2,0,0,0,0,4,0,4,2,4,0,13,15,-0.307497467071935,-0.137984496124031,0.0510278338274609,-0.446376811594203,0.679775280898876,0.863157894736842,0.00416666666666667,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.244,0.225,"6:4","147/150","L:V:C:I:M:A:T",1.42647319438274,0.0104102993024226,0.556804076010637,2.56189431047824,1.33944091330526,12.5461379903288,0.619509439957981,0.0142886927095374,1.84500750353971,1.15481122214044,14.4829286214949,0.0157176829434794,"lineage2","dr_mutations_pyrazinamide","GLY",0,"SAMN02628510","SRR1174309_SRR1173140","lineage2.2.1","ir","Iran","pnca_p.cys14gly","A","S","CYS","CA14","pnca_complex.pdb"
|
|
"C14G","L4","PZA","C","C14",14,"G",0,"Pre-XDR","DM","hydrophobic","hydrophobic","neutral","neutral","non-polar","non-polar",8.493,-1.214,-0.534,1.40101,-2.618,1.21,82,91,0.013,5,5,1,0.0059880239520958,"loop",0.6,5.76,0.0009343107661348,4.1639877189814,4.16398768969361,4.16339464867528,5.83418569155344,10,0,0,0,0,0,0,0,0,0,0,2,-2,0,0,0,0,4,0,4,2,4,0,13,15,-0.307497467071935,-0.137984496124031,0.0510278338274609,-0.446376811594203,0.679775280898876,0.863157894736842,0.00416666666666667,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.244,0.225,"6:4","147/150","L:V:C:I:M:A:T",1.42647319438274,0.0104102993024226,0.556804076010637,2.56189431047824,1.33944091330526,12.5461379903288,0.619509439957981,0.0142886927095374,1.84500750353971,1.15481122214044,14.4829286214949,0.0157176829434794,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR2516340","ERR2516340","lineage4.8","be","Belgium","pnca_p.cys14gly","A","S","CYS","CA14","pnca_complex.pdb"
|
|
"C14G","L4","PZA","C","C14",14,"G",NA,"XDR","DM","hydrophobic","hydrophobic","neutral","neutral","non-polar","non-polar",8.493,-1.214,-0.534,1.40101,-2.618,1.21,82,91,0.013,5,5,1,0.0059880239520958,"loop",0.6,5.76,0.0009343107661348,4.1639877189814,4.16398768969361,4.16339464867528,5.83418569155344,10,0,0,0,0,0,0,0,0,0,0,2,-2,0,0,0,0,4,0,4,2,4,0,13,15,-0.307497467071935,-0.137984496124031,0.0510278338274609,-0.446376811594203,0.679775280898876,0.863157894736842,0.00416666666666667,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.244,0.225,"6:4","147/150","L:V:C:I:M:A:T",1.42647319438274,0.0104102993024226,0.556804076010637,2.56189431047824,1.33944091330526,12.5461379903288,0.619509439957981,0.0142886927095374,1.84500750353971,1.15481122214044,14.4829286214949,0.0157176829434794,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR2510724","ERR2510724","lineage4.8","it","Italy","pnca_p.cys14gly","A","S","CYS","CA14","pnca_complex.pdb"
|
|
"C14G","L1","PZA","C","C14",14,"G",0,"MDR","DM","hydrophobic","hydrophobic","neutral","neutral","non-polar","non-polar",8.493,-1.214,-0.534,1.40101,-2.618,1.21,82,91,0.013,5,5,1,0.0059880239520958,"loop",0.6,5.76,0.0009343107661348,4.1639877189814,4.16398768969361,4.16339464867528,5.83418569155344,10,0,0,0,0,0,0,0,0,0,0,2,-2,0,0,0,0,4,0,4,2,4,0,13,15,-0.307497467071935,-0.137984496124031,0.0510278338274609,-0.446376811594203,0.679775280898876,0.863157894736842,0.00416666666666667,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.244,0.225,"6:4","147/150","L:V:C:I:M:A:T",1.42647319438274,0.0104102993024226,0.556804076010637,2.56189431047824,1.33944091330526,12.5461379903288,0.619509439957981,0.0142886927095374,1.84500750353971,1.15481122214044,14.4829286214949,0.0157176829434794,"lineage1","dr_mutations_pyrazinamide","GLY",0,"IEMDR05","ERR1952142","lineage1.1.2","ie","Ireland","pnca_p.cys14gly","A","S","CYS","CA14","pnca_complex.pdb"
|
|
"C14G","L2","PZA","C","C14",14,"G",NA,"XDR","DM","hydrophobic","hydrophobic","neutral","neutral","non-polar","non-polar",8.493,-1.214,-0.534,1.40101,-2.618,1.21,82,91,0.013,5,5,1,0.0059880239520958,"loop",0.6,5.76,0.0009343107661348,4.1639877189814,4.16398768969361,4.16339464867528,5.83418569155344,10,0,0,0,0,0,0,0,0,0,0,2,-2,0,0,0,0,4,0,4,2,4,0,13,15,-0.307497467071935,-0.137984496124031,0.0510278338274609,-0.446376811594203,0.679775280898876,0.863157894736842,0.00416666666666667,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.244,0.225,"6:4","147/150","L:V:C:I:M:A:T",1.42647319438274,0.0104102993024226,0.556804076010637,2.56189431047824,1.33944091330526,12.5461379903288,0.619509439957981,0.0142886927095374,1.84500750353971,1.15481122214044,14.4829286214949,0.0157176829434794,"lineage2","dr_mutations_pyrazinamide","GLY",0,"ERR751395","ERR751395","lineage2.2.1","pe","","pnca_p.cys14gly","A","S","CYS","CA14","pnca_complex.pdb"
|
|
"C14G","L1","PZA","C","C14",14,"G",0,"MDR","DM","hydrophobic","hydrophobic","neutral","neutral","non-polar","non-polar",8.493,-1.214,-0.534,1.40101,-2.618,1.21,82,91,0.013,5,5,1,0.0059880239520958,"loop",0.6,5.76,0.0009343107661348,4.1639877189814,4.16398768969361,4.16339464867528,5.83418569155344,10,0,0,0,0,0,0,0,0,0,0,2,-2,0,0,0,0,4,0,4,2,4,0,13,15,-0.307497467071935,-0.137984496124031,0.0510278338274609,-0.446376811594203,0.679775280898876,0.863157894736842,0.00416666666666667,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.244,0.225,"6:4","147/150","L:V:C:I:M:A:T",1.42647319438274,0.0104102993024226,0.556804076010637,2.56189431047824,1.33944091330526,12.5461379903288,0.619509439957981,0.0142886927095374,1.84500750353971,1.15481122214044,14.4829286214949,0.0157176829434794,"lineage1","dr_mutations_pyrazinamide","GLY",0,"ERR2516753","ERR2516753","lineage1.2.1","gb","UK","pnca_p.cys14gly","A","S","CYS","CA14","pnca_complex.pdb"
|
|
"C14G","L4","PZA","C","C14",14,"G",0,"Pre-XDR","DM","hydrophobic","hydrophobic","neutral","neutral","non-polar","non-polar",8.493,-1.214,-0.534,1.40101,-2.618,1.21,82,91,0.013,5,5,1,0.0059880239520958,"loop",0.6,5.76,0.0009343107661348,4.1639877189814,4.16398768969361,4.16339464867528,5.83418569155344,10,0,0,0,0,0,0,0,0,0,0,2,-2,0,0,0,0,4,0,4,2,4,0,13,15,-0.307497467071935,-0.137984496124031,0.0510278338274609,-0.446376811594203,0.679775280898876,0.863157894736842,0.00416666666666667,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.244,0.225,"6:4","147/150","L:V:C:I:M:A:T",1.42647319438274,0.0104102993024226,0.556804076010637,2.56189431047824,1.33944091330526,12.5461379903288,0.619509439957981,0.0142886927095374,1.84500750353971,1.15481122214044,14.4829286214949,0.0157176829434794,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR2516451","ERR2516451","lineage4.1.2.1","pe","Peru","pnca_p.cys14gly","A","S","CYS","CA14","pnca_complex.pdb"
|
|
"C14G","L2","PZA","C","C14",14,"G",NA,"MDR","DM","hydrophobic","hydrophobic","neutral","neutral","non-polar","non-polar",8.493,-1.214,-0.534,1.40101,-2.618,1.21,82,91,0.013,5,5,1,0.0059880239520958,"loop",0.6,5.76,0.0009343107661348,4.1639877189814,4.16398768969361,4.16339464867528,5.83418569155344,10,0,0,0,0,0,0,0,0,0,0,2,-2,0,0,0,0,4,0,4,2,4,0,13,15,-0.307497467071935,-0.137984496124031,0.0510278338274609,-0.446376811594203,0.679775280898876,0.863157894736842,0.00416666666666667,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.244,0.225,"6:4","147/150","L:V:C:I:M:A:T",1.42647319438274,0.0104102993024226,0.556804076010637,2.56189431047824,1.33944091330526,12.5461379903288,0.619509439957981,0.0142886927095374,1.84500750353971,1.15481122214044,14.4829286214949,0.0157176829434794,"lineage2","dr_mutations_pyrazinamide","GLY",0,"ERR1034738","ERR1034738","lineage2.2.1","pe","Peru","pnca_p.cys14gly","A","S","CYS","CA14","pnca_complex.pdb"
|
|
"C14G","L4","PZA","C","C14",14,"G",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","neutral","neutral","non-polar","non-polar",8.493,-1.214,-0.534,1.40101,-2.618,1.21,82,91,0.013,5,5,1,0.0059880239520958,"loop",0.6,5.76,0.0009343107661348,4.1639877189814,4.16398768969361,4.16339464867528,5.83418569155344,10,0,0,0,0,0,0,0,0,0,0,2,-2,0,0,0,0,4,0,4,2,4,0,13,15,-0.307497467071935,-0.137984496124031,0.0510278338274609,-0.446376811594203,0.679775280898876,0.863157894736842,0.00416666666666667,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.244,0.225,"6:4","147/150","L:V:C:I:M:A:T",1.42647319438274,0.0104102993024226,0.556804076010637,2.56189431047824,1.33944091330526,12.5461379903288,0.619509439957981,0.0142886927095374,1.84500750353971,1.15481122214044,14.4829286214949,0.0157176829434794,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR2516251","ERR2516251","lineage4.8","be","Belgium","pnca_p.cys14gly","A","S","CYS","CA14","pnca_complex.pdb"
|
|
"C14G","L4","PZA","C","C14",14,"G",1,"XDR","DM","hydrophobic","hydrophobic","neutral","neutral","non-polar","non-polar",8.493,-1.214,-0.534,1.40101,-2.618,1.21,82,91,0.013,5,5,1,0.0059880239520958,"loop",0.6,5.76,0.0009343107661348,4.1639877189814,4.16398768969361,4.16339464867528,5.83418569155344,10,0,0,0,0,0,0,0,0,0,0,2,-2,0,0,0,0,4,0,4,2,4,0,13,15,-0.307497467071935,-0.137984496124031,0.0510278338274609,-0.446376811594203,0.679775280898876,0.863157894736842,0.00416666666666667,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.244,0.225,"6:4","147/150","L:V:C:I:M:A:T",1.42647319438274,0.0104102993024226,0.556804076010637,2.56189431047824,1.33944091330526,12.5461379903288,0.619509439957981,0.0142886927095374,1.84500750353971,1.15481122214044,14.4829286214949,0.0157176829434794,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR2516597","ERR2516597","lineage4.1.2.1","pe","Peru","pnca_p.cys14gly","A","S","CYS","CA14","pnca_complex.pdb"
|
|
"C14R","L2","PZA","C","C14",14,"R",NA,"XDR","DM","hydrophobic","hydrophilic","neutral","basic","non-polar","pos",8.493,-1.215,-0.333,-1.79171,-2.708,0.11,81,91,0.013,5,5,1,0.0059880239520958,"loop",0.6,5.76,0.0034497628288055,42.4477739726027,42.4477736723918,42.4422996313437,173.445422378416,-58,-18,0,0,-18,0,0,0,0,-4,0,-2,-2,0,0,0,0,-5,0,-2,-3,0,0,-2,-2,-0.307750759878419,-0.0860465116279069,-0.344480119972314,-0.461722080136402,0.0617977528089887,0.852631578947368,0.00416666666666667,"Destabilising","Destabilising","Stabilising","Destabilising","Stabilising","effect",-0.244,0.225,"6:4","147/150","L:V:C:I:M:A:T",3.74827446550197,2.29709370000913e-15,0.473019029416408,7.92415152964658,18.4724160727947,122.828725767578,1.6278549200979,5.27268754098056e-28,27.2779679641604,16.8169087404394,137.378365631042,1.30826250297363e-39,"lineage2","dr_mutations_pyrazinamide","ARG",0,"ERR2516005","ERR2516005","lineage2.2.2","za","South Africa","pnca_p.cys14arg","A","S","CYS","CA14","pnca_complex.pdb"
|
|
"C14R","L2","PZA","C","C14",14,"R",1,"Pre-XDR","DM","hydrophobic","hydrophilic","neutral","basic","non-polar","pos",8.493,-1.215,-0.333,-1.79171,-2.708,0.11,81,91,0.013,5,5,1,0.0059880239520958,"loop",0.6,5.76,0.0034497628288055,42.4477739726027,42.4477736723918,42.4422996313437,173.445422378416,-58,-18,0,0,-18,0,0,0,0,-4,0,-2,-2,0,0,0,0,-5,0,-2,-3,0,0,-2,-2,-0.307750759878419,-0.0860465116279069,-0.344480119972314,-0.461722080136402,0.0617977528089887,0.852631578947368,0.00416666666666667,"Destabilising","Destabilising","Stabilising","Destabilising","Stabilising","effect",-0.244,0.225,"6:4","147/150","L:V:C:I:M:A:T",3.74827446550197,2.29709370000913e-15,0.473019029416408,7.92415152964658,18.4724160727947,122.828725767578,1.6278549200979,5.27268754098056e-28,27.2779679641604,16.8169087404394,137.378365631042,1.30826250297363e-39,"lineage2","dr_mutations_pyrazinamide","ARG",0,"ERR2515466","ERR2515466","lineage2.2.2","za","South Africa","pnca_p.cys14arg","A","S","CYS","CA14","pnca_complex.pdb"
|
|
"C14R","L1","PZA","C","C14",14,"R",NA,"Other","DM","hydrophobic","hydrophilic","neutral","basic","non-polar","pos",8.493,-1.215,-0.333,-1.79171,-2.708,0.11,81,91,0.013,5,5,1,0.0059880239520958,"loop",0.6,5.76,0.0034497628288055,42.4477739726027,42.4477736723918,42.4422996313437,173.445422378416,-58,-18,0,0,-18,0,0,0,0,-4,0,-2,-2,0,0,0,0,-5,0,-2,-3,0,0,-2,-2,-0.307750759878419,-0.0860465116279069,-0.344480119972314,-0.461722080136402,0.0617977528089887,0.852631578947368,0.00416666666666667,"Destabilising","Destabilising","Stabilising","Destabilising","Stabilising","effect",-0.244,0.225,"6:4","147/150","L:V:C:I:M:A:T",3.74827446550197,2.29709370000913e-15,0.473019029416408,7.92415152964658,18.4724160727947,122.828725767578,1.6278549200979,5.27268754098056e-28,27.2779679641604,16.8169087404394,137.378365631042,1.30826250297363e-39,"lineage1","dr_mutations_pyrazinamide","ARG",0,"SRR5074090","SRR5074090","lineage1.1.1","vn","Vietnam","pnca_p.cys14arg","A","S","CYS","CA14","pnca_complex.pdb"
|
|
"C14R","L2","PZA","C","C14",14,"R",0,"Pre-XDR","DM","hydrophobic","hydrophilic","neutral","basic","non-polar","pos",8.493,-1.215,-0.333,-1.79171,-2.708,0.11,81,91,0.013,5,5,1,0.0059880239520958,"loop",0.6,5.76,0.0034497628288055,42.4477739726027,42.4477736723918,42.4422996313437,173.445422378416,-58,-18,0,0,-18,0,0,0,0,-4,0,-2,-2,0,0,0,0,-5,0,-2,-3,0,0,-2,-2,-0.307750759878419,-0.0860465116279069,-0.344480119972314,-0.461722080136402,0.0617977528089887,0.852631578947368,0.00416666666666667,"Destabilising","Destabilising","Stabilising","Destabilising","Stabilising","effect",-0.244,0.225,"6:4","147/150","L:V:C:I:M:A:T",3.74827446550197,2.29709370000913e-15,0.473019029416408,7.92415152964658,18.4724160727947,122.828725767578,1.6278549200979,5.27268754098056e-28,27.2779679641604,16.8169087404394,137.378365631042,1.30826250297363e-39,"lineage2","dr_mutations_pyrazinamide","ARG",0,"ERR2517035","ERR2517035","lineage2.2.1","gb","UK","pnca_p.cys14arg","A","S","CYS","CA14","pnca_complex.pdb"
|
|
"C14R","L2","PZA","C","C14",14,"R",1,"XDR","DM","hydrophobic","hydrophilic","neutral","basic","non-polar","pos",8.493,-1.215,-0.333,-1.79171,-2.708,0.11,81,91,0.013,5,5,1,0.0059880239520958,"loop",0.6,5.76,0.0034497628288055,42.4477739726027,42.4477736723918,42.4422996313437,173.445422378416,-58,-18,0,0,-18,0,0,0,0,-4,0,-2,-2,0,0,0,0,-5,0,-2,-3,0,0,-2,-2,-0.307750759878419,-0.0860465116279069,-0.344480119972314,-0.461722080136402,0.0617977528089887,0.852631578947368,0.00416666666666667,"Destabilising","Destabilising","Stabilising","Destabilising","Stabilising","effect",-0.244,0.225,"6:4","147/150","L:V:C:I:M:A:T",3.74827446550197,2.29709370000913e-15,0.473019029416408,7.92415152964658,18.4724160727947,122.828725767578,1.6278549200979,5.27268754098056e-28,27.2779679641604,16.8169087404394,137.378365631042,1.30826250297363e-39,"lineage2","dr_mutations_pyrazinamide","ARG",0,"ERR1873525","ERR1873525","lineage2.2.2","za","South Africa","pnca_p.cys14arg","A","S","CYS","CA14","pnca_complex.pdb"
|
|
"C14R","L2","PZA","C","C14",14,"R",NA,"XDR","DM","hydrophobic","hydrophilic","neutral","basic","non-polar","pos",8.493,-1.215,-0.333,-1.79171,-2.708,0.11,81,91,0.013,5,5,1,0.0059880239520958,"loop",0.6,5.76,0.0034497628288055,42.4477739726027,42.4477736723918,42.4422996313437,173.445422378416,-58,-18,0,0,-18,0,0,0,0,-4,0,-2,-2,0,0,0,0,-5,0,-2,-3,0,0,-2,-2,-0.307750759878419,-0.0860465116279069,-0.344480119972314,-0.461722080136402,0.0617977528089887,0.852631578947368,0.00416666666666667,"Destabilising","Destabilising","Stabilising","Destabilising","Stabilising","effect",-0.244,0.225,"6:4","147/150","L:V:C:I:M:A:T",3.74827446550197,2.29709370000913e-15,0.473019029416408,7.92415152964658,18.4724160727947,122.828725767578,1.6278549200979,5.27268754098056e-28,27.2779679641604,16.8169087404394,137.378365631042,1.30826250297363e-39,"lineage2","dr_mutations_pyrazinamide","ARG",0,"ERR1035038","ERR1035038","lineage2.2.2","za","South Africa","pnca_p.cys14arg","A","S","CYS","CA14","pnca_complex.pdb"
|
|
"C14R","L2","PZA","C","C14",14,"R",1,"XDR","DM","hydrophobic","hydrophilic","neutral","basic","non-polar","pos",8.493,-1.215,-0.333,-1.79171,-2.708,0.11,81,91,0.013,5,5,1,0.0059880239520958,"loop",0.6,5.76,0.0034497628288055,42.4477739726027,42.4477736723918,42.4422996313437,173.445422378416,-58,-18,0,0,-18,0,0,0,0,-4,0,-2,-2,0,0,0,0,-5,0,-2,-3,0,0,-2,-2,-0.307750759878419,-0.0860465116279069,-0.344480119972314,-0.461722080136402,0.0617977528089887,0.852631578947368,0.00416666666666667,"Destabilising","Destabilising","Stabilising","Destabilising","Stabilising","effect",-0.244,0.225,"6:4","147/150","L:V:C:I:M:A:T",3.74827446550197,2.29709370000913e-15,0.473019029416408,7.92415152964658,18.4724160727947,122.828725767578,1.6278549200979,5.27268754098056e-28,27.2779679641604,16.8169087404394,137.378365631042,1.30826250297363e-39,"lineage2","dr_mutations_pyrazinamide","ARG",0,"ERR1873436","ERR1873436","lineage2.2.2","za","South Africa","pnca_p.cys14arg","A","S","CYS","CA14","pnca_complex.pdb"
|
|
"C14R","L2","PZA","C","C14",14,"R",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","neutral","basic","non-polar","pos",8.493,-1.215,-0.333,-1.79171,-2.708,0.11,81,91,0.013,5,5,1,0.0059880239520958,"loop",0.6,5.76,0.0034497628288055,42.4477739726027,42.4477736723918,42.4422996313437,173.445422378416,-58,-18,0,0,-18,0,0,0,0,-4,0,-2,-2,0,0,0,0,-5,0,-2,-3,0,0,-2,-2,-0.307750759878419,-0.0860465116279069,-0.344480119972314,-0.461722080136402,0.0617977528089887,0.852631578947368,0.00416666666666667,"Destabilising","Destabilising","Stabilising","Destabilising","Stabilising","effect",-0.244,0.225,"6:4","147/150","L:V:C:I:M:A:T",3.74827446550197,2.29709370000913e-15,0.473019029416408,7.92415152964658,18.4724160727947,122.828725767578,1.6278549200979,5.27268754098056e-28,27.2779679641604,16.8169087404394,137.378365631042,1.30826250297363e-39,"lineage2","dr_mutations_pyrazinamide","ARG",0,"ERR2514646","ERR2514646","lineage2.2.1","gb","UK","pnca_p.cys14arg","A","S","CYS","CA14","pnca_complex.pdb"
|
|
"C14R","L4","PZA","C","C14",14,"R",1,"Other","DM","hydrophobic","hydrophilic","neutral","basic","non-polar","pos",8.493,-1.215,-0.333,-1.79171,-2.708,0.11,81,91,0.013,5,5,1,0.0059880239520958,"loop",0.6,5.76,0.0034497628288055,42.4477739726027,42.4477736723918,42.4422996313437,173.445422378416,-58,-18,0,0,-18,0,0,0,0,-4,0,-2,-2,0,0,0,0,-5,0,-2,-3,0,0,-2,-2,-0.307750759878419,-0.0860465116279069,-0.344480119972314,-0.461722080136402,0.0617977528089887,0.852631578947368,0.00416666666666667,"Destabilising","Destabilising","Stabilising","Destabilising","Stabilising","effect",-0.244,0.225,"6:4","147/150","L:V:C:I:M:A:T",3.74827446550197,2.29709370000913e-15,0.473019029416408,7.92415152964658,18.4724160727947,122.828725767578,1.6278549200979,5.27268754098056e-28,27.2779679641604,16.8169087404394,137.378365631042,1.30826250297363e-39,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERR2515731","ERR2515731","lineage4.1.1.3","za","South Africa","pnca_p.cys14arg","A","S","CYS","CA14","pnca_complex.pdb"
|
|
"C14R","L2","PZA","C","C14",14,"R",1,"XDR","DM","hydrophobic","hydrophilic","neutral","basic","non-polar","pos",8.493,-1.215,-0.333,-1.79171,-2.708,0.11,81,91,0.013,5,5,1,0.0059880239520958,"loop",0.6,5.76,0.0034497628288055,42.4477739726027,42.4477736723918,42.4422996313437,173.445422378416,-58,-18,0,0,-18,0,0,0,0,-4,0,-2,-2,0,0,0,0,-5,0,-2,-3,0,0,-2,-2,-0.307750759878419,-0.0860465116279069,-0.344480119972314,-0.461722080136402,0.0617977528089887,0.852631578947368,0.00416666666666667,"Destabilising","Destabilising","Stabilising","Destabilising","Stabilising","effect",-0.244,0.225,"6:4","147/150","L:V:C:I:M:A:T",3.74827446550197,2.29709370000913e-15,0.473019029416408,7.92415152964658,18.4724160727947,122.828725767578,1.6278549200979,5.27268754098056e-28,27.2779679641604,16.8169087404394,137.378365631042,1.30826250297363e-39,"lineage2","dr_mutations_pyrazinamide","ARG",0,"ERR1873514","ERR1873514","lineage2.2.2","za","South Africa","pnca_p.cys14arg","A","S","CYS","CA14","pnca_complex.pdb"
|
|
"C14R","L2","PZA","C","C14",14,"R",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","neutral","basic","non-polar","pos",8.493,-1.215,-0.333,-1.79171,-2.708,0.11,81,91,0.013,5,5,1,0.0059880239520958,"loop",0.6,5.76,0.0034497628288055,42.4477739726027,42.4477736723918,42.4422996313437,173.445422378416,-58,-18,0,0,-18,0,0,0,0,-4,0,-2,-2,0,0,0,0,-5,0,-2,-3,0,0,-2,-2,-0.307750759878419,-0.0860465116279069,-0.344480119972314,-0.461722080136402,0.0617977528089887,0.852631578947368,0.00416666666666667,"Destabilising","Destabilising","Stabilising","Destabilising","Stabilising","effect",-0.244,0.225,"6:4","147/150","L:V:C:I:M:A:T",3.74827446550197,2.29709370000913e-15,0.473019029416408,7.92415152964658,18.4724160727947,122.828725767578,1.6278549200979,5.27268754098056e-28,27.2779679641604,16.8169087404394,137.378365631042,1.30826250297363e-39,"lineage2","dr_mutations_pyrazinamide","ARG",0,"ERR1035025","ERR1035025","lineage2.2.2","za","South Africa","pnca_p.cys14arg","A","S","CYS","CA14","pnca_complex.pdb"
|
|
"C14R","L2","PZA","C","C14",14,"R",NA,"XDR","DM","hydrophobic","hydrophilic","neutral","basic","non-polar","pos",8.493,-1.215,-0.333,-1.79171,-2.708,0.11,81,91,0.013,5,5,1,0.0059880239520958,"loop",0.6,5.76,0.0034497628288055,42.4477739726027,42.4477736723918,42.4422996313437,173.445422378416,-58,-18,0,0,-18,0,0,0,0,-4,0,-2,-2,0,0,0,0,-5,0,-2,-3,0,0,-2,-2,-0.307750759878419,-0.0860465116279069,-0.344480119972314,-0.461722080136402,0.0617977528089887,0.852631578947368,0.00416666666666667,"Destabilising","Destabilising","Stabilising","Destabilising","Stabilising","effect",-0.244,0.225,"6:4","147/150","L:V:C:I:M:A:T",3.74827446550197,2.29709370000913e-15,0.473019029416408,7.92415152964658,18.4724160727947,122.828725767578,1.6278549200979,5.27268754098056e-28,27.2779679641604,16.8169087404394,137.378365631042,1.30826250297363e-39,"lineage2","dr_mutations_pyrazinamide","ARG",0,"ERR2515768","ERR2515768","lineage2.2.2","za","South Africa","pnca_p.cys14arg","A","S","CYS","CA14","pnca_complex.pdb"
|
|
"C14R","L2","PZA","C","C14",14,"R",NA,"XDR","DM","hydrophobic","hydrophilic","neutral","basic","non-polar","pos",8.493,-1.215,-0.333,-1.79171,-2.708,0.11,81,91,0.013,5,5,1,0.0059880239520958,"loop",0.6,5.76,0.0034497628288055,42.4477739726027,42.4477736723918,42.4422996313437,173.445422378416,-58,-18,0,0,-18,0,0,0,0,-4,0,-2,-2,0,0,0,0,-5,0,-2,-3,0,0,-2,-2,-0.307750759878419,-0.0860465116279069,-0.344480119972314,-0.461722080136402,0.0617977528089887,0.852631578947368,0.00416666666666667,"Destabilising","Destabilising","Stabilising","Destabilising","Stabilising","effect",-0.244,0.225,"6:4","147/150","L:V:C:I:M:A:T",3.74827446550197,2.29709370000913e-15,0.473019029416408,7.92415152964658,18.4724160727947,122.828725767578,1.6278549200979,5.27268754098056e-28,27.2779679641604,16.8169087404394,137.378365631042,1.30826250297363e-39,"lineage2","dr_mutations_pyrazinamide","ARG",0,"ERR1035031","ERR1035031","lineage2.2.2","za","South Africa","pnca_p.cys14arg","A","S","CYS","CA14","pnca_complex.pdb"
|
|
"C14R","L2","PZA","C","C14",14,"R",1,"XDR","DM","hydrophobic","hydrophilic","neutral","basic","non-polar","pos",8.493,-1.215,-0.333,-1.79171,-2.708,0.11,81,91,0.013,5,5,1,0.0059880239520958,"loop",0.6,5.76,0.0034497628288055,42.4477739726027,42.4477736723918,42.4422996313437,173.445422378416,-58,-18,0,0,-18,0,0,0,0,-4,0,-2,-2,0,0,0,0,-5,0,-2,-3,0,0,-2,-2,-0.307750759878419,-0.0860465116279069,-0.344480119972314,-0.461722080136402,0.0617977528089887,0.852631578947368,0.00416666666666667,"Destabilising","Destabilising","Stabilising","Destabilising","Stabilising","effect",-0.244,0.225,"6:4","147/150","L:V:C:I:M:A:T",3.74827446550197,2.29709370000913e-15,0.473019029416408,7.92415152964658,18.4724160727947,122.828725767578,1.6278549200979,5.27268754098056e-28,27.2779679641604,16.8169087404394,137.378365631042,1.30826250297363e-39,"lineage2","dr_mutations_pyrazinamide","ARG",0,"ERR1873490","ERR1873490","lineage2.2.2","za","South Africa","pnca_p.cys14arg","A","S","CYS","CA14","pnca_complex.pdb"
|
|
"C14R","L2","PZA","C","C14",14,"R",1,"Pre-XDR","DM","hydrophobic","hydrophilic","neutral","basic","non-polar","pos",8.493,-1.215,-0.333,-1.79171,-2.708,0.11,81,91,0.013,5,5,1,0.0059880239520958,"loop",0.6,5.76,0.0034497628288055,42.4477739726027,42.4477736723918,42.4422996313437,173.445422378416,-58,-18,0,0,-18,0,0,0,0,-4,0,-2,-2,0,0,0,0,-5,0,-2,-3,0,0,-2,-2,-0.307750759878419,-0.0860465116279069,-0.344480119972314,-0.461722080136402,0.0617977528089887,0.852631578947368,0.00416666666666667,"Destabilising","Destabilising","Stabilising","Destabilising","Stabilising","effect",-0.244,0.225,"6:4","147/150","L:V:C:I:M:A:T",3.74827446550197,2.29709370000913e-15,0.473019029416408,7.92415152964658,18.4724160727947,122.828725767578,1.6278549200979,5.27268754098056e-28,27.2779679641604,16.8169087404394,137.378365631042,1.30826250297363e-39,"lineage2","dr_mutations_pyrazinamide","ARG",0,"ERR2512718","ERR2512718","lineage2.2.1","gb","UK","pnca_p.cys14arg","A","S","CYS","CA14","pnca_complex.pdb"
|
|
"C14R","L2","PZA","C","C14",14,"R",1,"Pre-XDR","DM","hydrophobic","hydrophilic","neutral","basic","non-polar","pos",8.493,-1.215,-0.333,-1.79171,-2.708,0.11,81,91,0.013,5,5,1,0.0059880239520958,"loop",0.6,5.76,0.0034497628288055,42.4477739726027,42.4477736723918,42.4422996313437,173.445422378416,-58,-18,0,0,-18,0,0,0,0,-4,0,-2,-2,0,0,0,0,-5,0,-2,-3,0,0,-2,-2,-0.307750759878419,-0.0860465116279069,-0.344480119972314,-0.461722080136402,0.0617977528089887,0.852631578947368,0.00416666666666667,"Destabilising","Destabilising","Stabilising","Destabilising","Stabilising","effect",-0.244,0.225,"6:4","147/150","L:V:C:I:M:A:T",3.74827446550197,2.29709370000913e-15,0.473019029416408,7.92415152964658,18.4724160727947,122.828725767578,1.6278549200979,5.27268754098056e-28,27.2779679641604,16.8169087404394,137.378365631042,1.30826250297363e-39,"lineage2","dr_mutations_pyrazinamide","ARG",0,"SRR2101731,SAMN03648978","SRR2101731","lineage2.2.2","","","pnca_p.cys14arg","A","S","CYS","CA14","pnca_complex.pdb"
|
|
"C14R","L4","PZA","C","C14",14,"R",NA,"Other","DM","hydrophobic","hydrophilic","neutral","basic","non-polar","pos",8.493,-1.215,-0.333,-1.79171,-2.708,0.11,81,91,0.013,5,5,1,0.0059880239520958,"loop",0.6,5.76,0.0034497628288055,42.4477739726027,42.4477736723918,42.4422996313437,173.445422378416,-58,-18,0,0,-18,0,0,0,0,-4,0,-2,-2,0,0,0,0,-5,0,-2,-3,0,0,-2,-2,-0.307750759878419,-0.0860465116279069,-0.344480119972314,-0.461722080136402,0.0617977528089887,0.852631578947368,0.00416666666666667,"Destabilising","Destabilising","Stabilising","Destabilising","Stabilising","effect",-0.244,0.225,"6:4","147/150","L:V:C:I:M:A:T",3.74827446550197,2.29709370000913e-15,0.473019029416408,7.92415152964658,18.4724160727947,122.828725767578,1.6278549200979,5.27268754098056e-28,27.2779679641604,16.8169087404394,137.378365631042,1.30826250297363e-39,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERR1633949","ERR1633949","lineage4.1.1.3","za","South Africa","pnca_p.cys14arg","A","S","CYS","CA14","pnca_complex.pdb"
|
|
"C14R","L2","PZA","C","C14",14,"R",1,"XDR","DM","hydrophobic","hydrophilic","neutral","basic","non-polar","pos",8.493,-1.215,-0.333,-1.79171,-2.708,0.11,81,91,0.013,5,5,1,0.0059880239520958,"loop",0.6,5.76,0.0034497628288055,42.4477739726027,42.4477736723918,42.4422996313437,173.445422378416,-58,-18,0,0,-18,0,0,0,0,-4,0,-2,-2,0,0,0,0,-5,0,-2,-3,0,0,-2,-2,-0.307750759878419,-0.0860465116279069,-0.344480119972314,-0.461722080136402,0.0617977528089887,0.852631578947368,0.00416666666666667,"Destabilising","Destabilising","Stabilising","Destabilising","Stabilising","effect",-0.244,0.225,"6:4","147/150","L:V:C:I:M:A:T",3.74827446550197,2.29709370000913e-15,0.473019029416408,7.92415152964658,18.4724160727947,122.828725767578,1.6278549200979,5.27268754098056e-28,27.2779679641604,16.8169087404394,137.378365631042,1.30826250297363e-39,"lineage2","dr_mutations_pyrazinamide","ARG",0,"ERR1873542","ERR1873542","lineage2.2.2","za","South Africa","pnca_p.cys14arg","A","S","CYS","CA14","pnca_complex.pdb"
|
|
"C14R","L2","PZA","C","C14",14,"R",1,"XDR","DM","hydrophobic","hydrophilic","neutral","basic","non-polar","pos",8.493,-1.215,-0.333,-1.79171,-2.708,0.11,81,91,0.013,5,5,1,0.0059880239520958,"loop",0.6,5.76,0.0034497628288055,42.4477739726027,42.4477736723918,42.4422996313437,173.445422378416,-58,-18,0,0,-18,0,0,0,0,-4,0,-2,-2,0,0,0,0,-5,0,-2,-3,0,0,-2,-2,-0.307750759878419,-0.0860465116279069,-0.344480119972314,-0.461722080136402,0.0617977528089887,0.852631578947368,0.00416666666666667,"Destabilising","Destabilising","Stabilising","Destabilising","Stabilising","effect",-0.244,0.225,"6:4","147/150","L:V:C:I:M:A:T",3.74827446550197,2.29709370000913e-15,0.473019029416408,7.92415152964658,18.4724160727947,122.828725767578,1.6278549200979,5.27268754098056e-28,27.2779679641604,16.8169087404394,137.378365631042,1.30826250297363e-39,"lineage2","dr_mutations_pyrazinamide","ARG",0,"ERR1873495","ERR1873495","lineage2.2.2","za","South Africa","pnca_p.cys14arg","A","S","CYS","CA14","pnca_complex.pdb"
|
|
"C14R","L2","PZA","C","C14",14,"R",NA,"XDR","DM","hydrophobic","hydrophilic","neutral","basic","non-polar","pos",8.493,-1.215,-0.333,-1.79171,-2.708,0.11,81,91,0.013,5,5,1,0.0059880239520958,"loop",0.6,5.76,0.0034497628288055,42.4477739726027,42.4477736723918,42.4422996313437,173.445422378416,-58,-18,0,0,-18,0,0,0,0,-4,0,-2,-2,0,0,0,0,-5,0,-2,-3,0,0,-2,-2,-0.307750759878419,-0.0860465116279069,-0.344480119972314,-0.461722080136402,0.0617977528089887,0.852631578947368,0.00416666666666667,"Destabilising","Destabilising","Stabilising","Destabilising","Stabilising","effect",-0.244,0.225,"6:4","147/150","L:V:C:I:M:A:T",3.74827446550197,2.29709370000913e-15,0.473019029416408,7.92415152964658,18.4724160727947,122.828725767578,1.6278549200979,5.27268754098056e-28,27.2779679641604,16.8169087404394,137.378365631042,1.30826250297363e-39,"lineage2","dr_mutations_pyrazinamide","ARG",0,"ERR1023454","ERR1023454","lineage2.2.2","","","pnca_p.cys14arg","A","S","CYS","CA14","pnca_complex.pdb"
|
|
"C14R","L2","PZA","C","C14",14,"R",NA,"MDR","DM","hydrophobic","hydrophilic","neutral","basic","non-polar","pos",8.493,-1.215,-0.333,-1.79171,-2.708,0.11,81,91,0.013,5,5,1,0.0059880239520958,"loop",0.6,5.76,0.0034497628288055,42.4477739726027,42.4477736723918,42.4422996313437,173.445422378416,-58,-18,0,0,-18,0,0,0,0,-4,0,-2,-2,0,0,0,0,-5,0,-2,-3,0,0,-2,-2,-0.307750759878419,-0.0860465116279069,-0.344480119972314,-0.461722080136402,0.0617977528089887,0.852631578947368,0.00416666666666667,"Destabilising","Destabilising","Stabilising","Destabilising","Stabilising","effect",-0.244,0.225,"6:4","147/150","L:V:C:I:M:A:T",3.74827446550197,2.29709370000913e-15,0.473019029416408,7.92415152964658,18.4724160727947,122.828725767578,1.6278549200979,5.27268754098056e-28,27.2779679641604,16.8169087404394,137.378365631042,1.30826250297363e-39,"lineage2","dr_mutations_pyrazinamide","ARG",0,"ERR1633869","ERR1633869","lineage2.2.2","za","South Africa","pnca_p.cys14arg","A","S","CYS","CA14","pnca_complex.pdb"
|
|
"C14R","L2","PZA","C","C14",14,"R",1,"XDR","DM","hydrophobic","hydrophilic","neutral","basic","non-polar","pos",8.493,-1.215,-0.333,-1.79171,-2.708,0.11,81,91,0.013,5,5,1,0.0059880239520958,"loop",0.6,5.76,0.0034497628288055,42.4477739726027,42.4477736723918,42.4422996313437,173.445422378416,-58,-18,0,0,-18,0,0,0,0,-4,0,-2,-2,0,0,0,0,-5,0,-2,-3,0,0,-2,-2,-0.307750759878419,-0.0860465116279069,-0.344480119972314,-0.461722080136402,0.0617977528089887,0.852631578947368,0.00416666666666667,"Destabilising","Destabilising","Stabilising","Destabilising","Stabilising","effect",-0.244,0.225,"6:4","147/150","L:V:C:I:M:A:T",3.74827446550197,2.29709370000913e-15,0.473019029416408,7.92415152964658,18.4724160727947,122.828725767578,1.6278549200979,5.27268754098056e-28,27.2779679641604,16.8169087404394,137.378365631042,1.30826250297363e-39,"lineage2","dr_mutations_pyrazinamide","ARG",0,"ERR1873520","ERR1873520","lineage2.2.2","za","South Africa","pnca_p.cys14arg","A","S","CYS","CA14","pnca_complex.pdb"
|
|
"C14R","L2","PZA","C","C14",14,"R",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","neutral","basic","non-polar","pos",8.493,-1.215,-0.333,-1.79171,-2.708,0.11,81,91,0.013,5,5,1,0.0059880239520958,"loop",0.6,5.76,0.0034497628288055,42.4477739726027,42.4477736723918,42.4422996313437,173.445422378416,-58,-18,0,0,-18,0,0,0,0,-4,0,-2,-2,0,0,0,0,-5,0,-2,-3,0,0,-2,-2,-0.307750759878419,-0.0860465116279069,-0.344480119972314,-0.461722080136402,0.0617977528089887,0.852631578947368,0.00416666666666667,"Destabilising","Destabilising","Stabilising","Destabilising","Stabilising","effect",-0.244,0.225,"6:4","147/150","L:V:C:I:M:A:T",3.74827446550197,2.29709370000913e-15,0.473019029416408,7.92415152964658,18.4724160727947,122.828725767578,1.6278549200979,5.27268754098056e-28,27.2779679641604,16.8169087404394,137.378365631042,1.30826250297363e-39,"lineage2","dr_mutations_pyrazinamide","ARG",0,"ERR1035036","ERR1035036","lineage2.2.2","za","South Africa","pnca_p.cys14arg","A","S","CYS","CA14","pnca_complex.pdb"
|
|
"C14R","L2","PZA","C","C14",14,"R",NA,"MDR","DM","hydrophobic","hydrophilic","neutral","basic","non-polar","pos",8.493,-1.215,-0.333,-1.79171,-2.708,0.11,81,91,0.013,5,5,1,0.0059880239520958,"loop",0.6,5.76,0.0034497628288055,42.4477739726027,42.4477736723918,42.4422996313437,173.445422378416,-58,-18,0,0,-18,0,0,0,0,-4,0,-2,-2,0,0,0,0,-5,0,-2,-3,0,0,-2,-2,-0.307750759878419,-0.0860465116279069,-0.344480119972314,-0.461722080136402,0.0617977528089887,0.852631578947368,0.00416666666666667,"Destabilising","Destabilising","Stabilising","Destabilising","Stabilising","effect",-0.244,0.225,"6:4","147/150","L:V:C:I:M:A:T",3.74827446550197,2.29709370000913e-15,0.473019029416408,7.92415152964658,18.4724160727947,122.828725767578,1.6278549200979,5.27268754098056e-28,27.2779679641604,16.8169087404394,137.378365631042,1.30826250297363e-39,"lineage2","dr_mutations_pyrazinamide","ARG",0,"SAMN02350470","SRR1140947_SRR1019148","lineage2.2.2","za","South Africa","pnca_p.cys14arg","A","S","CYS","CA14","pnca_complex.pdb"
|
|
"C14R","L4","PZA","C","C14",14,"R",1,"MDR","DM","hydrophobic","hydrophilic","neutral","basic","non-polar","pos",8.493,-1.215,-0.333,-1.79171,-2.708,0.11,81,91,0.013,5,5,1,0.0059880239520958,"loop",0.6,5.76,0.0034497628288055,42.4477739726027,42.4477736723918,42.4422996313437,173.445422378416,-58,-18,0,0,-18,0,0,0,0,-4,0,-2,-2,0,0,0,0,-5,0,-2,-3,0,0,-2,-2,-0.307750759878419,-0.0860465116279069,-0.344480119972314,-0.461722080136402,0.0617977528089887,0.852631578947368,0.00416666666666667,"Destabilising","Destabilising","Stabilising","Destabilising","Stabilising","effect",-0.244,0.225,"6:4","147/150","L:V:C:I:M:A:T",3.74827446550197,2.29709370000913e-15,0.473019029416408,7.92415152964658,18.4724160727947,122.828725767578,1.6278549200979,5.27268754098056e-28,27.2779679641604,16.8169087404394,137.378365631042,1.30826250297363e-39,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERR1873506","ERR1873506","lineage4.1.1.3","za","South Africa","pnca_p.cys14arg","A","S","CYS","CA14","pnca_complex.pdb"
|
|
"C14R","L2","PZA","C","C14",14,"R",NA,"XDR","DM","hydrophobic","hydrophilic","neutral","basic","non-polar","pos",8.493,-1.215,-0.333,-1.79171,-2.708,0.11,81,91,0.013,5,5,1,0.0059880239520958,"loop",0.6,5.76,0.0034497628288055,42.4477739726027,42.4477736723918,42.4422996313437,173.445422378416,-58,-18,0,0,-18,0,0,0,0,-4,0,-2,-2,0,0,0,0,-5,0,-2,-3,0,0,-2,-2,-0.307750759878419,-0.0860465116279069,-0.344480119972314,-0.461722080136402,0.0617977528089887,0.852631578947368,0.00416666666666667,"Destabilising","Destabilising","Stabilising","Destabilising","Stabilising","effect",-0.244,0.225,"6:4","147/150","L:V:C:I:M:A:T",3.74827446550197,2.29709370000913e-15,0.473019029416408,7.92415152964658,18.4724160727947,122.828725767578,1.6278549200979,5.27268754098056e-28,27.2779679641604,16.8169087404394,137.378365631042,1.30826250297363e-39,"lineage2","dr_mutations_pyrazinamide","ARG",0,"ERR2516019","ERR2516019","lineage2.2.2","za","South Africa","pnca_p.cys14arg","A","S","CYS","CA14","pnca_complex.pdb"
|
|
"C14R","L2","PZA","C","C14",14,"R",1,"XDR","DM","hydrophobic","hydrophilic","neutral","basic","non-polar","pos",8.493,-1.215,-0.333,-1.79171,-2.708,0.11,81,91,0.013,5,5,1,0.0059880239520958,"loop",0.6,5.76,0.0034497628288055,42.4477739726027,42.4477736723918,42.4422996313437,173.445422378416,-58,-18,0,0,-18,0,0,0,0,-4,0,-2,-2,0,0,0,0,-5,0,-2,-3,0,0,-2,-2,-0.307750759878419,-0.0860465116279069,-0.344480119972314,-0.461722080136402,0.0617977528089887,0.852631578947368,0.00416666666666667,"Destabilising","Destabilising","Stabilising","Destabilising","Stabilising","effect",-0.244,0.225,"6:4","147/150","L:V:C:I:M:A:T",3.74827446550197,2.29709370000913e-15,0.473019029416408,7.92415152964658,18.4724160727947,122.828725767578,1.6278549200979,5.27268754098056e-28,27.2779679641604,16.8169087404394,137.378365631042,1.30826250297363e-39,"lineage2","dr_mutations_pyrazinamide","ARG",0,"ERR1873468","ERR1873468","lineage2.2.2","za","South Africa","pnca_p.cys14arg","A","S","CYS","CA14","pnca_complex.pdb"
|
|
"C14R","L2","PZA","C","C14",14,"R",1,"Pre-XDR","DM","hydrophobic","hydrophilic","neutral","basic","non-polar","pos",8.493,-1.215,-0.333,-1.79171,-2.708,0.11,81,91,0.013,5,5,1,0.0059880239520958,"loop",0.6,5.76,0.0034497628288055,42.4477739726027,42.4477736723918,42.4422996313437,173.445422378416,-58,-18,0,0,-18,0,0,0,0,-4,0,-2,-2,0,0,0,0,-5,0,-2,-3,0,0,-2,-2,-0.307750759878419,-0.0860465116279069,-0.344480119972314,-0.461722080136402,0.0617977528089887,0.852631578947368,0.00416666666666667,"Destabilising","Destabilising","Stabilising","Destabilising","Stabilising","effect",-0.244,0.225,"6:4","147/150","L:V:C:I:M:A:T",3.74827446550197,2.29709370000913e-15,0.473019029416408,7.92415152964658,18.4724160727947,122.828725767578,1.6278549200979,5.27268754098056e-28,27.2779679641604,16.8169087404394,137.378365631042,1.30826250297363e-39,"lineage2","dr_mutations_pyrazinamide","ARG",0,"SRR2101384,SAMN03648631","SRR2101384","lineage2.2.2","","","pnca_p.cys14arg","A","S","CYS","CA14","pnca_complex.pdb"
|
|
"C14R","L2","PZA","C","C14",14,"R",1,"XDR","DM","hydrophobic","hydrophilic","neutral","basic","non-polar","pos",8.493,-1.215,-0.333,-1.79171,-2.708,0.11,81,91,0.013,5,5,1,0.0059880239520958,"loop",0.6,5.76,0.0034497628288055,42.4477739726027,42.4477736723918,42.4422996313437,173.445422378416,-58,-18,0,0,-18,0,0,0,0,-4,0,-2,-2,0,0,0,0,-5,0,-2,-3,0,0,-2,-2,-0.307750759878419,-0.0860465116279069,-0.344480119972314,-0.461722080136402,0.0617977528089887,0.852631578947368,0.00416666666666667,"Destabilising","Destabilising","Stabilising","Destabilising","Stabilising","effect",-0.244,0.225,"6:4","147/150","L:V:C:I:M:A:T",3.74827446550197,2.29709370000913e-15,0.473019029416408,7.92415152964658,18.4724160727947,122.828725767578,1.6278549200979,5.27268754098056e-28,27.2779679641604,16.8169087404394,137.378365631042,1.30826250297363e-39,"lineage2","dr_mutations_pyrazinamide","ARG",0,"ERR1873552","ERR1873552","lineage2.2.2","za","South Africa","pnca_p.cys14arg","A","S","CYS","CA14","pnca_complex.pdb"
|
|
"C14R","L2","PZA","C","C14",14,"R",NA,"XDR","DM","hydrophobic","hydrophilic","neutral","basic","non-polar","pos",8.493,-1.215,-0.333,-1.79171,-2.708,0.11,81,91,0.013,5,5,1,0.0059880239520958,"loop",0.6,5.76,0.0034497628288055,42.4477739726027,42.4477736723918,42.4422996313437,173.445422378416,-58,-18,0,0,-18,0,0,0,0,-4,0,-2,-2,0,0,0,0,-5,0,-2,-3,0,0,-2,-2,-0.307750759878419,-0.0860465116279069,-0.344480119972314,-0.461722080136402,0.0617977528089887,0.852631578947368,0.00416666666666667,"Destabilising","Destabilising","Stabilising","Destabilising","Stabilising","effect",-0.244,0.225,"6:4","147/150","L:V:C:I:M:A:T",3.74827446550197,2.29709370000913e-15,0.473019029416408,7.92415152964658,18.4724160727947,122.828725767578,1.6278549200979,5.27268754098056e-28,27.2779679641604,16.8169087404394,137.378365631042,1.30826250297363e-39,"lineage2","dr_mutations_pyrazinamide","ARG",0,"SAMN02414982","SRR1162803_SRR1165558_SRR1165478_SRR1162868","lineage2.2.2","se","Sweden","pnca_p.cys14arg","A","S","CYS","CA14","pnca_complex.pdb"
|
|
"C14R","L2","PZA","C","C14",14,"R",1,"XDR","DM","hydrophobic","hydrophilic","neutral","basic","non-polar","pos",8.493,-1.215,-0.333,-1.79171,-2.708,0.11,81,91,0.013,5,5,1,0.0059880239520958,"loop",0.6,5.76,0.0034497628288055,42.4477739726027,42.4477736723918,42.4422996313437,173.445422378416,-58,-18,0,0,-18,0,0,0,0,-4,0,-2,-2,0,0,0,0,-5,0,-2,-3,0,0,-2,-2,-0.307750759878419,-0.0860465116279069,-0.344480119972314,-0.461722080136402,0.0617977528089887,0.852631578947368,0.00416666666666667,"Destabilising","Destabilising","Stabilising","Destabilising","Stabilising","effect",-0.244,0.225,"6:4","147/150","L:V:C:I:M:A:T",3.74827446550197,2.29709370000913e-15,0.473019029416408,7.92415152964658,18.4724160727947,122.828725767578,1.6278549200979,5.27268754098056e-28,27.2779679641604,16.8169087404394,137.378365631042,1.30826250297363e-39,"lineage2","dr_mutations_pyrazinamide","ARG",0,"ERR1873529","ERR1873529","lineage2.2.2","za","South Africa","pnca_p.cys14arg","A","S","CYS","CA14","pnca_complex.pdb"
|
|
"C14R","L2","PZA","C","C14",14,"R",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","neutral","basic","non-polar","pos",8.493,-1.215,-0.333,-1.79171,-2.708,0.11,81,91,0.013,5,5,1,0.0059880239520958,"loop",0.6,5.76,0.0034497628288055,42.4477739726027,42.4477736723918,42.4422996313437,173.445422378416,-58,-18,0,0,-18,0,0,0,0,-4,0,-2,-2,0,0,0,0,-5,0,-2,-3,0,0,-2,-2,-0.307750759878419,-0.0860465116279069,-0.344480119972314,-0.461722080136402,0.0617977528089887,0.852631578947368,0.00416666666666667,"Destabilising","Destabilising","Stabilising","Destabilising","Stabilising","effect",-0.244,0.225,"6:4","147/150","L:V:C:I:M:A:T",3.74827446550197,2.29709370000913e-15,0.473019029416408,7.92415152964658,18.4724160727947,122.828725767578,1.6278549200979,5.27268754098056e-28,27.2779679641604,16.8169087404394,137.378365631042,1.30826250297363e-39,"lineage2","dr_mutations_pyrazinamide","ARG",0,"ERR1023480","ERR1023480","lineage2.2.2","","","pnca_p.cys14arg","A","S","CYS","CA14","pnca_complex.pdb"
|
|
"C14R","L2","PZA","C","C14",14,"R",NA,"MDR","DM","hydrophobic","hydrophilic","neutral","basic","non-polar","pos",8.493,-1.215,-0.333,-1.79171,-2.708,0.11,81,91,0.013,5,5,1,0.0059880239520958,"loop",0.6,5.76,0.0034497628288055,42.4477739726027,42.4477736723918,42.4422996313437,173.445422378416,-58,-18,0,0,-18,0,0,0,0,-4,0,-2,-2,0,0,0,0,-5,0,-2,-3,0,0,-2,-2,-0.307750759878419,-0.0860465116279069,-0.344480119972314,-0.461722080136402,0.0617977528089887,0.852631578947368,0.00416666666666667,"Destabilising","Destabilising","Stabilising","Destabilising","Stabilising","effect",-0.244,0.225,"6:4","147/150","L:V:C:I:M:A:T",3.74827446550197,2.29709370000913e-15,0.473019029416408,7.92415152964658,18.4724160727947,122.828725767578,1.6278549200979,5.27268754098056e-28,27.2779679641604,16.8169087404394,137.378365631042,1.30826250297363e-39,"lineage2","dr_mutations_pyrazinamide","ARG",0,"SAMN02350473","SRR1140916_SRR1019152","lineage2.2.2","za","South Africa","pnca_p.cys14arg","A","S","CYS","CA14","pnca_complex.pdb"
|
|
"C14R","L2","PZA","C","C14",14,"R",1,"XDR","DM","hydrophobic","hydrophilic","neutral","basic","non-polar","pos",8.493,-1.215,-0.333,-1.79171,-2.708,0.11,81,91,0.013,5,5,1,0.0059880239520958,"loop",0.6,5.76,0.0034497628288055,42.4477739726027,42.4477736723918,42.4422996313437,173.445422378416,-58,-18,0,0,-18,0,0,0,0,-4,0,-2,-2,0,0,0,0,-5,0,-2,-3,0,0,-2,-2,-0.307750759878419,-0.0860465116279069,-0.344480119972314,-0.461722080136402,0.0617977528089887,0.852631578947368,0.00416666666666667,"Destabilising","Destabilising","Stabilising","Destabilising","Stabilising","effect",-0.244,0.225,"6:4","147/150","L:V:C:I:M:A:T",3.74827446550197,2.29709370000913e-15,0.473019029416408,7.92415152964658,18.4724160727947,122.828725767578,1.6278549200979,5.27268754098056e-28,27.2779679641604,16.8169087404394,137.378365631042,1.30826250297363e-39,"lineage2","dr_mutations_pyrazinamide","ARG",0,"ERR1873553","ERR1873553","lineage2.2.2","za","South Africa","pnca_p.cys14arg","A","S","CYS","CA14","pnca_complex.pdb"
|
|
"C14R","L4","PZA","C","C14",14,"R",NA,"Pre-MDR","DM","hydrophobic","hydrophilic","neutral","basic","non-polar","pos",8.493,-1.215,-0.333,-1.79171,-2.708,0.11,81,91,0.013,5,5,1,0.0059880239520958,"loop",0.6,5.76,0.0034497628288055,42.4477739726027,42.4477736723918,42.4422996313437,173.445422378416,-58,-18,0,0,-18,0,0,0,0,-4,0,-2,-2,0,0,0,0,-5,0,-2,-3,0,0,-2,-2,-0.307750759878419,-0.0860465116279069,-0.344480119972314,-0.461722080136402,0.0617977528089887,0.852631578947368,0.00416666666666667,"Destabilising","Destabilising","Stabilising","Destabilising","Stabilising","effect",-0.244,0.225,"6:4","147/150","L:V:C:I:M:A:T",3.74827446550197,2.29709370000913e-15,0.473019029416408,7.92415152964658,18.4724160727947,122.828725767578,1.6278549200979,5.27268754098056e-28,27.2779679641604,16.8169087404394,137.378365631042,1.30826250297363e-39,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERR2706974","ERR2706974","lineage4.3.4.2","cd","Democratic Republic of Congo","pnca_p.cys14arg","A","S","CYS","CA14","pnca_complex.pdb"
|
|
"C14R","L2","PZA","C","C14",14,"R",1,"Pre-XDR","DM","hydrophobic","hydrophilic","neutral","basic","non-polar","pos",8.493,-1.215,-0.333,-1.79171,-2.708,0.11,81,91,0.013,5,5,1,0.0059880239520958,"loop",0.6,5.76,0.0034497628288055,42.4477739726027,42.4477736723918,42.4422996313437,173.445422378416,-58,-18,0,0,-18,0,0,0,0,-4,0,-2,-2,0,0,0,0,-5,0,-2,-3,0,0,-2,-2,-0.307750759878419,-0.0860465116279069,-0.344480119972314,-0.461722080136402,0.0617977528089887,0.852631578947368,0.00416666666666667,"Destabilising","Destabilising","Stabilising","Destabilising","Stabilising","effect",-0.244,0.225,"6:4","147/150","L:V:C:I:M:A:T",3.74827446550197,2.29709370000913e-15,0.473019029416408,7.92415152964658,18.4724160727947,122.828725767578,1.6278549200979,5.27268754098056e-28,27.2779679641604,16.8169087404394,137.378365631042,1.30826250297363e-39,"lineage2","dr_mutations_pyrazinamide","ARG",0,"ERR2510853","ERR2510853","lineage2.2.1","it","Italy","pnca_p.cys14arg","A","S","CYS","CA14","pnca_complex.pdb"
|
|
"C14R","L4","PZA","C","C14",14,"R",1,"Other","DM","hydrophobic","hydrophilic","neutral","basic","non-polar","pos",8.493,-1.215,-0.333,-1.79171,-2.708,0.11,81,91,0.013,5,5,1,0.0059880239520958,"loop",0.6,5.76,0.0034497628288055,42.4477739726027,42.4477736723918,42.4422996313437,173.445422378416,-58,-18,0,0,-18,0,0,0,0,-4,0,-2,-2,0,0,0,0,-5,0,-2,-3,0,0,-2,-2,-0.307750759878419,-0.0860465116279069,-0.344480119972314,-0.461722080136402,0.0617977528089887,0.852631578947368,0.00416666666666667,"Destabilising","Destabilising","Stabilising","Destabilising","Stabilising","effect",-0.244,0.225,"6:4","147/150","L:V:C:I:M:A:T",3.74827446550197,2.29709370000913e-15,0.473019029416408,7.92415152964658,18.4724160727947,122.828725767578,1.6278549200979,5.27268754098056e-28,27.2779679641604,16.8169087404394,137.378365631042,1.30826250297363e-39,"lineage4","dr_mutations_pyrazinamide","ARG",0,"SRR2101813,SAMN03649060","SRR2101813","lineage4.1.1.3","","","pnca_p.cys14arg","A","S","CYS","CA14","pnca_complex.pdb"
|
|
"C14R","L2","PZA","C","C14",14,"R",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","neutral","basic","non-polar","pos",8.493,-1.215,-0.333,-1.79171,-2.708,0.11,81,91,0.013,5,5,1,0.0059880239520958,"loop",0.6,5.76,0.0034497628288055,42.4477739726027,42.4477736723918,42.4422996313437,173.445422378416,-58,-18,0,0,-18,0,0,0,0,-4,0,-2,-2,0,0,0,0,-5,0,-2,-3,0,0,-2,-2,-0.307750759878419,-0.0860465116279069,-0.344480119972314,-0.461722080136402,0.0617977528089887,0.852631578947368,0.00416666666666667,"Destabilising","Destabilising","Stabilising","Destabilising","Stabilising","effect",-0.244,0.225,"6:4","147/150","L:V:C:I:M:A:T",3.74827446550197,2.29709370000913e-15,0.473019029416408,7.92415152964658,18.4724160727947,122.828725767578,1.6278549200979,5.27268754098056e-28,27.2779679641604,16.8169087404394,137.378365631042,1.30826250297363e-39,"lineage2","dr_mutations_pyrazinamide","ARG",0,"SAMN07658851","SRR6045824","lineage2.2.1","gb","UK","pnca_p.cys14arg","A","S","CYS","CA14","pnca_complex.pdb"
|
|
"C14R","L4","PZA","C","C14",14,"R",NA,"Other","DM","hydrophobic","hydrophilic","neutral","basic","non-polar","pos",8.493,-1.215,-0.333,-1.79171,-2.708,0.11,81,91,0.013,5,5,1,0.0059880239520958,"loop",0.6,5.76,0.0034497628288055,42.4477739726027,42.4477736723918,42.4422996313437,173.445422378416,-58,-18,0,0,-18,0,0,0,0,-4,0,-2,-2,0,0,0,0,-5,0,-2,-3,0,0,-2,-2,-0.307750759878419,-0.0860465116279069,-0.344480119972314,-0.461722080136402,0.0617977528089887,0.852631578947368,0.00416666666666667,"Destabilising","Destabilising","Stabilising","Destabilising","Stabilising","effect",-0.244,0.225,"6:4","147/150","L:V:C:I:M:A:T",3.74827446550197,2.29709370000913e-15,0.473019029416408,7.92415152964658,18.4724160727947,122.828725767578,1.6278549200979,5.27268754098056e-28,27.2779679641604,16.8169087404394,137.378365631042,1.30826250297363e-39,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERS3466689","ERR3340717","lineage4.1.1.3","za","","pnca_p.cys14arg","A","S","CYS","CA14","pnca_complex.pdb"
|
|
"C14R","L2","PZA","C","C14",14,"R",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","neutral","basic","non-polar","pos",8.493,-1.215,-0.333,-1.79171,-2.708,0.11,81,91,0.013,5,5,1,0.0059880239520958,"loop",0.6,5.76,0.0034497628288055,42.4477739726027,42.4477736723918,42.4422996313437,173.445422378416,-58,-18,0,0,-18,0,0,0,0,-4,0,-2,-2,0,0,0,0,-5,0,-2,-3,0,0,-2,-2,-0.307750759878419,-0.0860465116279069,-0.344480119972314,-0.461722080136402,0.0617977528089887,0.852631578947368,0.00416666666666667,"Destabilising","Destabilising","Stabilising","Destabilising","Stabilising","effect",-0.244,0.225,"6:4","147/150","L:V:C:I:M:A:T",3.74827446550197,2.29709370000913e-15,0.473019029416408,7.92415152964658,18.4724160727947,122.828725767578,1.6278549200979,5.27268754098056e-28,27.2779679641604,16.8169087404394,137.378365631042,1.30826250297363e-39,"lineage2","dr_mutations_pyrazinamide","ARG",0,"ERR2515144","ERR2515144","lineage2.2.2","za","South Africa","pnca_p.cys14arg","A","S","CYS","CA14","pnca_complex.pdb"
|
|
"C14R","L2","PZA","C","C14",14,"R",1,"MDR","DM","hydrophobic","hydrophilic","neutral","basic","non-polar","pos",8.493,-1.215,-0.333,-1.79171,-2.708,0.11,81,91,0.013,5,5,1,0.0059880239520958,"loop",0.6,5.76,0.0034497628288055,42.4477739726027,42.4477736723918,42.4422996313437,173.445422378416,-58,-18,0,0,-18,0,0,0,0,-4,0,-2,-2,0,0,0,0,-5,0,-2,-3,0,0,-2,-2,-0.307750759878419,-0.0860465116279069,-0.344480119972314,-0.461722080136402,0.0617977528089887,0.852631578947368,0.00416666666666667,"Destabilising","Destabilising","Stabilising","Destabilising","Stabilising","effect",-0.244,0.225,"6:4","147/150","L:V:C:I:M:A:T",3.74827446550197,2.29709370000913e-15,0.473019029416408,7.92415152964658,18.4724160727947,122.828725767578,1.6278549200979,5.27268754098056e-28,27.2779679641604,16.8169087404394,137.378365631042,1.30826250297363e-39,"lineage2","dr_mutations_pyrazinamide","ARG",0,"ERR1873463","ERR1873463","lineage2.2.2","za","South Africa","pnca_p.cys14arg","A","S","CYS","CA14","pnca_complex.pdb"
|
|
"C14R","L2","PZA","C","C14",14,"R",1,"XDR","DM","hydrophobic","hydrophilic","neutral","basic","non-polar","pos",8.493,-1.215,-0.333,-1.79171,-2.708,0.11,81,91,0.013,5,5,1,0.0059880239520958,"loop",0.6,5.76,0.0034497628288055,42.4477739726027,42.4477736723918,42.4422996313437,173.445422378416,-58,-18,0,0,-18,0,0,0,0,-4,0,-2,-2,0,0,0,0,-5,0,-2,-3,0,0,-2,-2,-0.307750759878419,-0.0860465116279069,-0.344480119972314,-0.461722080136402,0.0617977528089887,0.852631578947368,0.00416666666666667,"Destabilising","Destabilising","Stabilising","Destabilising","Stabilising","effect",-0.244,0.225,"6:4","147/150","L:V:C:I:M:A:T",3.74827446550197,2.29709370000913e-15,0.473019029416408,7.92415152964658,18.4724160727947,122.828725767578,1.6278549200979,5.27268754098056e-28,27.2779679641604,16.8169087404394,137.378365631042,1.30826250297363e-39,"lineage2","dr_mutations_pyrazinamide","ARG",0,"ERR1873503","ERR1873503","lineage2.2.2","za","South Africa","pnca_p.cys14arg","A","S","CYS","CA14","pnca_complex.pdb"
|
|
"C14R","L2","PZA","C","C14",14,"R",1,"XDR","DM","hydrophobic","hydrophilic","neutral","basic","non-polar","pos",8.493,-1.215,-0.333,-1.79171,-2.708,0.11,81,91,0.013,5,5,1,0.0059880239520958,"loop",0.6,5.76,0.0034497628288055,42.4477739726027,42.4477736723918,42.4422996313437,173.445422378416,-58,-18,0,0,-18,0,0,0,0,-4,0,-2,-2,0,0,0,0,-5,0,-2,-3,0,0,-2,-2,-0.307750759878419,-0.0860465116279069,-0.344480119972314,-0.461722080136402,0.0617977528089887,0.852631578947368,0.00416666666666667,"Destabilising","Destabilising","Stabilising","Destabilising","Stabilising","effect",-0.244,0.225,"6:4","147/150","L:V:C:I:M:A:T",3.74827446550197,2.29709370000913e-15,0.473019029416408,7.92415152964658,18.4724160727947,122.828725767578,1.6278549200979,5.27268754098056e-28,27.2779679641604,16.8169087404394,137.378365631042,1.30826250297363e-39,"lineage2","dr_mutations_pyrazinamide","ARG",0,"ERR1873496","ERR1873496","lineage2.2.2","za","South Africa","pnca_p.cys14arg","A","S","CYS","CA14","pnca_complex.pdb"
|
|
"C14R","L2","PZA","C","C14",14,"R",1,"XDR","DM","hydrophobic","hydrophilic","neutral","basic","non-polar","pos",8.493,-1.215,-0.333,-1.79171,-2.708,0.11,81,91,0.013,5,5,1,0.0059880239520958,"loop",0.6,5.76,0.0034497628288055,42.4477739726027,42.4477736723918,42.4422996313437,173.445422378416,-58,-18,0,0,-18,0,0,0,0,-4,0,-2,-2,0,0,0,0,-5,0,-2,-3,0,0,-2,-2,-0.307750759878419,-0.0860465116279069,-0.344480119972314,-0.461722080136402,0.0617977528089887,0.852631578947368,0.00416666666666667,"Destabilising","Destabilising","Stabilising","Destabilising","Stabilising","effect",-0.244,0.225,"6:4","147/150","L:V:C:I:M:A:T",3.74827446550197,2.29709370000913e-15,0.473019029416408,7.92415152964658,18.4724160727947,122.828725767578,1.6278549200979,5.27268754098056e-28,27.2779679641604,16.8169087404394,137.378365631042,1.30826250297363e-39,"lineage2","dr_mutations_pyrazinamide","ARG",0,"ERR1873429","ERR1873429","lineage2.2.2","za","South Africa","pnca_p.cys14arg","A","S","CYS","CA14","pnca_complex.pdb"
|
|
"C14R","L2","PZA","C","C14",14,"R",NA,"XDR","DM","hydrophobic","hydrophilic","neutral","basic","non-polar","pos",8.493,-1.215,-0.333,-1.79171,-2.708,0.11,81,91,0.013,5,5,1,0.0059880239520958,"loop",0.6,5.76,0.0034497628288055,42.4477739726027,42.4477736723918,42.4422996313437,173.445422378416,-58,-18,0,0,-18,0,0,0,0,-4,0,-2,-2,0,0,0,0,-5,0,-2,-3,0,0,-2,-2,-0.307750759878419,-0.0860465116279069,-0.344480119972314,-0.461722080136402,0.0617977528089887,0.852631578947368,0.00416666666666667,"Destabilising","Destabilising","Stabilising","Destabilising","Stabilising","effect",-0.244,0.225,"6:4","147/150","L:V:C:I:M:A:T",3.74827446550197,2.29709370000913e-15,0.473019029416408,7.92415152964658,18.4724160727947,122.828725767578,1.6278549200979,5.27268754098056e-28,27.2779679641604,16.8169087404394,137.378365631042,1.30826250297363e-39,"lineage2","dr_mutations_pyrazinamide","ARG",0,"ERR2516066","ERR2516066","lineage2.2.2","za","South Africa","pnca_p.cys14arg","A","S","CYS","CA14","pnca_complex.pdb"
|
|
"C14R","L2","PZA","C","C14",14,"R",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","neutral","basic","non-polar","pos",8.493,-1.215,-0.333,-1.79171,-2.708,0.11,81,91,0.013,5,5,1,0.0059880239520958,"loop",0.6,5.76,0.0034497628288055,42.4477739726027,42.4477736723918,42.4422996313437,173.445422378416,-58,-18,0,0,-18,0,0,0,0,-4,0,-2,-2,0,0,0,0,-5,0,-2,-3,0,0,-2,-2,-0.307750759878419,-0.0860465116279069,-0.344480119972314,-0.461722080136402,0.0617977528089887,0.852631578947368,0.00416666666666667,"Destabilising","Destabilising","Stabilising","Destabilising","Stabilising","effect",-0.244,0.225,"6:4","147/150","L:V:C:I:M:A:T",3.74827446550197,2.29709370000913e-15,0.473019029416408,7.92415152964658,18.4724160727947,122.828725767578,1.6278549200979,5.27268754098056e-28,27.2779679641604,16.8169087404394,137.378365631042,1.30826250297363e-39,"lineage2","dr_mutations_pyrazinamide","ARG",0,"SAMN07659981","SRR6045245","lineage2.2.1","gb","UK","pnca_p.cys14arg","A","S","CYS","CA14","pnca_complex.pdb"
|
|
"C14R","L2","PZA","C","C14",14,"R",1,"Pre-XDR","DM","hydrophobic","hydrophilic","neutral","basic","non-polar","pos",8.493,-1.215,-0.333,-1.79171,-2.708,0.11,81,91,0.013,5,5,1,0.0059880239520958,"loop",0.6,5.76,0.0034497628288055,42.4477739726027,42.4477736723918,42.4422996313437,173.445422378416,-58,-18,0,0,-18,0,0,0,0,-4,0,-2,-2,0,0,0,0,-5,0,-2,-3,0,0,-2,-2,-0.307750759878419,-0.0860465116279069,-0.344480119972314,-0.461722080136402,0.0617977528089887,0.852631578947368,0.00416666666666667,"Destabilising","Destabilising","Stabilising","Destabilising","Stabilising","effect",-0.244,0.225,"6:4","147/150","L:V:C:I:M:A:T",3.74827446550197,2.29709370000913e-15,0.473019029416408,7.92415152964658,18.4724160727947,122.828725767578,1.6278549200979,5.27268754098056e-28,27.2779679641604,16.8169087404394,137.378365631042,1.30826250297363e-39,"lineage2","dr_mutations_pyrazinamide","ARG",0,"ERR1873504","ERR1873504","lineage2.2.2","za","South Africa","pnca_p.cys14arg","A","S","CYS","CA14","pnca_complex.pdb"
|
|
"C14R","L2","PZA","C","C14",14,"R",NA,"XDR","DM","hydrophobic","hydrophilic","neutral","basic","non-polar","pos",8.493,-1.215,-0.333,-1.79171,-2.708,0.11,81,91,0.013,5,5,1,0.0059880239520958,"loop",0.6,5.76,0.0034497628288055,42.4477739726027,42.4477736723918,42.4422996313437,173.445422378416,-58,-18,0,0,-18,0,0,0,0,-4,0,-2,-2,0,0,0,0,-5,0,-2,-3,0,0,-2,-2,-0.307750759878419,-0.0860465116279069,-0.344480119972314,-0.461722080136402,0.0617977528089887,0.852631578947368,0.00416666666666667,"Destabilising","Destabilising","Stabilising","Destabilising","Stabilising","effect",-0.244,0.225,"6:4","147/150","L:V:C:I:M:A:T",3.74827446550197,2.29709370000913e-15,0.473019029416408,7.92415152964658,18.4724160727947,122.828725767578,1.6278549200979,5.27268754098056e-28,27.2779679641604,16.8169087404394,137.378365631042,1.30826250297363e-39,"lineage2","dr_mutations_pyrazinamide","ARG",0,"ERR2515864","ERR2515864","lineage2.2.2","za","South Africa","pnca_p.cys14arg","A","S","CYS","CA14","pnca_complex.pdb"
|
|
"C14R","L4","PZA","C","C14",14,"R",NA,"Other","DM","hydrophobic","hydrophilic","neutral","basic","non-polar","pos",8.493,-1.215,-0.333,-1.79171,-2.708,0.11,81,91,0.013,5,5,1,0.0059880239520958,"loop",0.6,5.76,0.0034497628288055,42.4477739726027,42.4477736723918,42.4422996313437,173.445422378416,-58,-18,0,0,-18,0,0,0,0,-4,0,-2,-2,0,0,0,0,-5,0,-2,-3,0,0,-2,-2,-0.307750759878419,-0.0860465116279069,-0.344480119972314,-0.461722080136402,0.0617977528089887,0.852631578947368,0.00416666666666667,"Destabilising","Destabilising","Stabilising","Destabilising","Stabilising","effect",-0.244,0.225,"6:4","147/150","L:V:C:I:M:A:T",3.74827446550197,2.29709370000913e-15,0.473019029416408,7.92415152964658,18.4724160727947,122.828725767578,1.6278549200979,5.27268754098056e-28,27.2779679641604,16.8169087404394,137.378365631042,1.30826250297363e-39,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERS3466684","ERR3340712","lineage4.1.1.3","za","","pnca_p.cys14arg","A","S","CYS","CA14","pnca_complex.pdb"
|
|
"C14R","L2","PZA","C","C14",14,"R",NA,"MDR","DM","hydrophobic","hydrophilic","neutral","basic","non-polar","pos",8.493,-1.215,-0.333,-1.79171,-2.708,0.11,81,91,0.013,5,5,1,0.0059880239520958,"loop",0.6,5.76,0.0034497628288055,42.4477739726027,42.4477736723918,42.4422996313437,173.445422378416,-58,-18,0,0,-18,0,0,0,0,-4,0,-2,-2,0,0,0,0,-5,0,-2,-3,0,0,-2,-2,-0.307750759878419,-0.0860465116279069,-0.344480119972314,-0.461722080136402,0.0617977528089887,0.852631578947368,0.00416666666666667,"Destabilising","Destabilising","Stabilising","Destabilising","Stabilising","effect",-0.244,0.225,"6:4","147/150","L:V:C:I:M:A:T",3.74827446550197,2.29709370000913e-15,0.473019029416408,7.92415152964658,18.4724160727947,122.828725767578,1.6278549200979,5.27268754098056e-28,27.2779679641604,16.8169087404394,137.378365631042,1.30826250297363e-39,"lineage2","dr_mutations_pyrazinamide","ARG",0,"SAMN02403616","SRR1167372_SRR1169294_SRR1169219_SRR1165637","lineage2.2.1","za","South Africa","pnca_p.cys14arg","A","S","CYS","CA14","pnca_complex.pdb"
|
|
"C14R","L4","PZA","C","C14",14,"R",1,"Other","DM","hydrophobic","hydrophilic","neutral","basic","non-polar","pos",8.493,-1.215,-0.333,-1.79171,-2.708,0.11,81,91,0.013,5,5,1,0.0059880239520958,"loop",0.6,5.76,0.0034497628288055,42.4477739726027,42.4477736723918,42.4422996313437,173.445422378416,-58,-18,0,0,-18,0,0,0,0,-4,0,-2,-2,0,0,0,0,-5,0,-2,-3,0,0,-2,-2,-0.307750759878419,-0.0860465116279069,-0.344480119972314,-0.461722080136402,0.0617977528089887,0.852631578947368,0.00416666666666667,"Destabilising","Destabilising","Stabilising","Destabilising","Stabilising","effect",-0.244,0.225,"6:4","147/150","L:V:C:I:M:A:T",3.74827446550197,2.29709370000913e-15,0.473019029416408,7.92415152964658,18.4724160727947,122.828725767578,1.6278549200979,5.27268754098056e-28,27.2779679641604,16.8169087404394,137.378365631042,1.30826250297363e-39,"lineage4","dr_mutations_pyrazinamide","ARG",0,"SAMN03648758,SRR2101511","SRR2101511","lineage4.1.1.3","","","pnca_p.cys14arg","A","S","CYS","CA14","pnca_complex.pdb"
|
|
"C14R","L2","PZA","C","C14",14,"R",NA,"MDR","DM","hydrophobic","hydrophilic","neutral","basic","non-polar","pos",8.493,-1.215,-0.333,-1.79171,-2.708,0.11,81,91,0.013,5,5,1,0.0059880239520958,"loop",0.6,5.76,0.0034497628288055,42.4477739726027,42.4477736723918,42.4422996313437,173.445422378416,-58,-18,0,0,-18,0,0,0,0,-4,0,-2,-2,0,0,0,0,-5,0,-2,-3,0,0,-2,-2,-0.307750759878419,-0.0860465116279069,-0.344480119972314,-0.461722080136402,0.0617977528089887,0.852631578947368,0.00416666666666667,"Destabilising","Destabilising","Stabilising","Destabilising","Stabilising","effect",-0.244,0.225,"6:4","147/150","L:V:C:I:M:A:T",3.74827446550197,2.29709370000913e-15,0.473019029416408,7.92415152964658,18.4724160727947,122.828725767578,1.6278549200979,5.27268754098056e-28,27.2779679641604,16.8169087404394,137.378365631042,1.30826250297363e-39,"lineage2","dr_mutations_pyrazinamide","ARG",0,"SAMN02403614","SRR1165686_SRR1172147_SRR1169123_SRR1165692","lineage2.2.2","za","South Africa","pnca_p.cys14arg","A","S","CYS","CA14","pnca_complex.pdb"
|
|
"C14R","L2","PZA","C","C14",14,"R",1,"Pre-XDR","DM","hydrophobic","hydrophilic","neutral","basic","non-polar","pos",8.493,-1.215,-0.333,-1.79171,-2.708,0.11,81,91,0.013,5,5,1,0.0059880239520958,"loop",0.6,5.76,0.0034497628288055,42.4477739726027,42.4477736723918,42.4422996313437,173.445422378416,-58,-18,0,0,-18,0,0,0,0,-4,0,-2,-2,0,0,0,0,-5,0,-2,-3,0,0,-2,-2,-0.307750759878419,-0.0860465116279069,-0.344480119972314,-0.461722080136402,0.0617977528089887,0.852631578947368,0.00416666666666667,"Destabilising","Destabilising","Stabilising","Destabilising","Stabilising","effect",-0.244,0.225,"6:4","147/150","L:V:C:I:M:A:T",3.74827446550197,2.29709370000913e-15,0.473019029416408,7.92415152964658,18.4724160727947,122.828725767578,1.6278549200979,5.27268754098056e-28,27.2779679641604,16.8169087404394,137.378365631042,1.30826250297363e-39,"lineage2","dr_mutations_pyrazinamide","ARG",0,"ERR2510707","ERR2510707","lineage2.2.1","it","Italy","pnca_p.cys14arg","A","S","CYS","CA14","pnca_complex.pdb"
|
|
"C14R","L2","PZA","C","C14",14,"R",0,"MDR","DM","hydrophobic","hydrophilic","neutral","basic","non-polar","pos",8.493,-1.215,-0.333,-1.79171,-2.708,0.11,81,91,0.013,5,5,1,0.0059880239520958,"loop",0.6,5.76,0.0034497628288055,42.4477739726027,42.4477736723918,42.4422996313437,173.445422378416,-58,-18,0,0,-18,0,0,0,0,-4,0,-2,-2,0,0,0,0,-5,0,-2,-3,0,0,-2,-2,-0.307750759878419,-0.0860465116279069,-0.344480119972314,-0.461722080136402,0.0617977528089887,0.852631578947368,0.00416666666666667,"Destabilising","Destabilising","Stabilising","Destabilising","Stabilising","effect",-0.244,0.225,"6:4","147/150","L:V:C:I:M:A:T",3.74827446550197,2.29709370000913e-15,0.473019029416408,7.92415152964658,18.4724160727947,122.828725767578,1.6278549200979,5.27268754098056e-28,27.2779679641604,16.8169087404394,137.378365631042,1.30826250297363e-39,"lineage2","dr_mutations_pyrazinamide","ARG",0,"ERR2515448","ERR2515448","lineage2.2.2","za","South Africa","pnca_p.cys14arg","A","S","CYS","CA14","pnca_complex.pdb"
|
|
"C14R","L2","PZA","C","C14",14,"R",NA,"XDR","DM","hydrophobic","hydrophilic","neutral","basic","non-polar","pos",8.493,-1.215,-0.333,-1.79171,-2.708,0.11,81,91,0.013,5,5,1,0.0059880239520958,"loop",0.6,5.76,0.0034497628288055,42.4477739726027,42.4477736723918,42.4422996313437,173.445422378416,-58,-18,0,0,-18,0,0,0,0,-4,0,-2,-2,0,0,0,0,-5,0,-2,-3,0,0,-2,-2,-0.307750759878419,-0.0860465116279069,-0.344480119972314,-0.461722080136402,0.0617977528089887,0.852631578947368,0.00416666666666667,"Destabilising","Destabilising","Stabilising","Destabilising","Stabilising","effect",-0.244,0.225,"6:4","147/150","L:V:C:I:M:A:T",3.74827446550197,2.29709370000913e-15,0.473019029416408,7.92415152964658,18.4724160727947,122.828725767578,1.6278549200979,5.27268754098056e-28,27.2779679641604,16.8169087404394,137.378365631042,1.30826250297363e-39,"lineage2","dr_mutations_pyrazinamide","ARG",0,"ERR1035041","ERR1035041","lineage2.2.2","za","South Africa","pnca_p.cys14arg","A","S","CYS","CA14","pnca_complex.pdb"
|
|
"C14R","L2","PZA","C","C14",14,"R",1,"XDR","DM","hydrophobic","hydrophilic","neutral","basic","non-polar","pos",8.493,-1.215,-0.333,-1.79171,-2.708,0.11,81,91,0.013,5,5,1,0.0059880239520958,"loop",0.6,5.76,0.0034497628288055,42.4477739726027,42.4477736723918,42.4422996313437,173.445422378416,-58,-18,0,0,-18,0,0,0,0,-4,0,-2,-2,0,0,0,0,-5,0,-2,-3,0,0,-2,-2,-0.307750759878419,-0.0860465116279069,-0.344480119972314,-0.461722080136402,0.0617977528089887,0.852631578947368,0.00416666666666667,"Destabilising","Destabilising","Stabilising","Destabilising","Stabilising","effect",-0.244,0.225,"6:4","147/150","L:V:C:I:M:A:T",3.74827446550197,2.29709370000913e-15,0.473019029416408,7.92415152964658,18.4724160727947,122.828725767578,1.6278549200979,5.27268754098056e-28,27.2779679641604,16.8169087404394,137.378365631042,1.30826250297363e-39,"lineage2","dr_mutations_pyrazinamide","ARG",0,"ERR1873497","ERR1873497","lineage2.2.2","za","South Africa","pnca_p.cys14arg","A","S","CYS","CA14","pnca_complex.pdb"
|
|
"C14R","L2","PZA","C","C14",14,"R",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","neutral","basic","non-polar","pos",8.493,-1.215,-0.333,-1.79171,-2.708,0.11,81,91,0.013,5,5,1,0.0059880239520958,"loop",0.6,5.76,0.0034497628288055,42.4477739726027,42.4477736723918,42.4422996313437,173.445422378416,-58,-18,0,0,-18,0,0,0,0,-4,0,-2,-2,0,0,0,0,-5,0,-2,-3,0,0,-2,-2,-0.307750759878419,-0.0860465116279069,-0.344480119972314,-0.461722080136402,0.0617977528089887,0.852631578947368,0.00416666666666667,"Destabilising","Destabilising","Stabilising","Destabilising","Stabilising","effect",-0.244,0.225,"6:4","147/150","L:V:C:I:M:A:T",3.74827446550197,2.29709370000913e-15,0.473019029416408,7.92415152964658,18.4724160727947,122.828725767578,1.6278549200979,5.27268754098056e-28,27.2779679641604,16.8169087404394,137.378365631042,1.30826250297363e-39,"lineage2","dr_mutations_pyrazinamide","ARG",0,"ERR2515544","ERR2515544","lineage2.2.2","za","South Africa","pnca_p.cys14arg","A","S","CYS","CA14","pnca_complex.pdb"
|
|
"C14R","L4","PZA","C","C14",14,"R",NA,"Other","DM","hydrophobic","hydrophilic","neutral","basic","non-polar","pos",8.493,-1.215,-0.333,-1.79171,-2.708,0.11,81,91,0.013,5,5,1,0.0059880239520958,"loop",0.6,5.76,0.0034497628288055,42.4477739726027,42.4477736723918,42.4422996313437,173.445422378416,-58,-18,0,0,-18,0,0,0,0,-4,0,-2,-2,0,0,0,0,-5,0,-2,-3,0,0,-2,-2,-0.307750759878419,-0.0860465116279069,-0.344480119972314,-0.461722080136402,0.0617977528089887,0.852631578947368,0.00416666666666667,"Destabilising","Destabilising","Stabilising","Destabilising","Stabilising","effect",-0.244,0.225,"6:4","147/150","L:V:C:I:M:A:T",3.74827446550197,2.29709370000913e-15,0.473019029416408,7.92415152964658,18.4724160727947,122.828725767578,1.6278549200979,5.27268754098056e-28,27.2779679641604,16.8169087404394,137.378365631042,1.30826250297363e-39,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERS3466683","ERR3340711","lineage4.1.1.3","za","","pnca_p.cys14arg","A","S","CYS","CA14","pnca_complex.pdb"
|
|
"C14R","L2","PZA","C","C14",14,"R",1,"Pre-XDR","DM","hydrophobic","hydrophilic","neutral","basic","non-polar","pos",8.493,-1.215,-0.333,-1.79171,-2.708,0.11,81,91,0.013,5,5,1,0.0059880239520958,"loop",0.6,5.76,0.0034497628288055,42.4477739726027,42.4477736723918,42.4422996313437,173.445422378416,-58,-18,0,0,-18,0,0,0,0,-4,0,-2,-2,0,0,0,0,-5,0,-2,-3,0,0,-2,-2,-0.307750759878419,-0.0860465116279069,-0.344480119972314,-0.461722080136402,0.0617977528089887,0.852631578947368,0.00416666666666667,"Destabilising","Destabilising","Stabilising","Destabilising","Stabilising","effect",-0.244,0.225,"6:4","147/150","L:V:C:I:M:A:T",3.74827446550197,2.29709370000913e-15,0.473019029416408,7.92415152964658,18.4724160727947,122.828725767578,1.6278549200979,5.27268754098056e-28,27.2779679641604,16.8169087404394,137.378365631042,1.30826250297363e-39,"lineage2","dr_mutations_pyrazinamide","ARG",0,"ERR1873486","ERR1873486","lineage2.2.2","za","South Africa","pnca_p.cys14arg","A","S","CYS","CA14","pnca_complex.pdb"
|
|
"C14R","L2","PZA","C","C14",14,"R",NA,"XDR","DM","hydrophobic","hydrophilic","neutral","basic","non-polar","pos",8.493,-1.215,-0.333,-1.79171,-2.708,0.11,81,91,0.013,5,5,1,0.0059880239520958,"loop",0.6,5.76,0.0034497628288055,42.4477739726027,42.4477736723918,42.4422996313437,173.445422378416,-58,-18,0,0,-18,0,0,0,0,-4,0,-2,-2,0,0,0,0,-5,0,-2,-3,0,0,-2,-2,-0.307750759878419,-0.0860465116279069,-0.344480119972314,-0.461722080136402,0.0617977528089887,0.852631578947368,0.00416666666666667,"Destabilising","Destabilising","Stabilising","Destabilising","Stabilising","effect",-0.244,0.225,"6:4","147/150","L:V:C:I:M:A:T",3.74827446550197,2.29709370000913e-15,0.473019029416408,7.92415152964658,18.4724160727947,122.828725767578,1.6278549200979,5.27268754098056e-28,27.2779679641604,16.8169087404394,137.378365631042,1.30826250297363e-39,"lineage2","dr_mutations_pyrazinamide","ARG",0,"ERR1035077","ERR1035077","lineage2.2.2","za","South Africa","pnca_p.cys14arg","A","S","CYS","CA14","pnca_complex.pdb"
|
|
"C14R","L2","PZA","C","C14",14,"R",1,"XDR","DM","hydrophobic","hydrophilic","neutral","basic","non-polar","pos",8.493,-1.215,-0.333,-1.79171,-2.708,0.11,81,91,0.013,5,5,1,0.0059880239520958,"loop",0.6,5.76,0.0034497628288055,42.4477739726027,42.4477736723918,42.4422996313437,173.445422378416,-58,-18,0,0,-18,0,0,0,0,-4,0,-2,-2,0,0,0,0,-5,0,-2,-3,0,0,-2,-2,-0.307750759878419,-0.0860465116279069,-0.344480119972314,-0.461722080136402,0.0617977528089887,0.852631578947368,0.00416666666666667,"Destabilising","Destabilising","Stabilising","Destabilising","Stabilising","effect",-0.244,0.225,"6:4","147/150","L:V:C:I:M:A:T",3.74827446550197,2.29709370000913e-15,0.473019029416408,7.92415152964658,18.4724160727947,122.828725767578,1.6278549200979,5.27268754098056e-28,27.2779679641604,16.8169087404394,137.378365631042,1.30826250297363e-39,"lineage2","dr_mutations_pyrazinamide","ARG",0,"ERR1873523","ERR1873523","lineage2.2.2","za","South Africa","pnca_p.cys14arg","A","S","CYS","CA14","pnca_complex.pdb"
|
|
"C14R","L2","PZA","C","C14",14,"R",1,"XDR","DM","hydrophobic","hydrophilic","neutral","basic","non-polar","pos",8.493,-1.215,-0.333,-1.79171,-2.708,0.11,81,91,0.013,5,5,1,0.0059880239520958,"loop",0.6,5.76,0.0034497628288055,42.4477739726027,42.4477736723918,42.4422996313437,173.445422378416,-58,-18,0,0,-18,0,0,0,0,-4,0,-2,-2,0,0,0,0,-5,0,-2,-3,0,0,-2,-2,-0.307750759878419,-0.0860465116279069,-0.344480119972314,-0.461722080136402,0.0617977528089887,0.852631578947368,0.00416666666666667,"Destabilising","Destabilising","Stabilising","Destabilising","Stabilising","effect",-0.244,0.225,"6:4","147/150","L:V:C:I:M:A:T",3.74827446550197,2.29709370000913e-15,0.473019029416408,7.92415152964658,18.4724160727947,122.828725767578,1.6278549200979,5.27268754098056e-28,27.2779679641604,16.8169087404394,137.378365631042,1.30826250297363e-39,"lineage2","dr_mutations_pyrazinamide","ARG",0,"ERR1873494","ERR1873494","lineage2.2.2","za","South Africa","pnca_p.cys14arg","A","S","CYS","CA14","pnca_complex.pdb"
|
|
"C14R","L4","PZA","C","C14",14,"R",NA,"MDR","DM","hydrophobic","hydrophilic","neutral","basic","non-polar","pos",8.493,-1.215,-0.333,-1.79171,-2.708,0.11,81,91,0.013,5,5,1,0.0059880239520958,"loop",0.6,5.76,0.0034497628288055,42.4477739726027,42.4477736723918,42.4422996313437,173.445422378416,-58,-18,0,0,-18,0,0,0,0,-4,0,-2,-2,0,0,0,0,-5,0,-2,-3,0,0,-2,-2,-0.307750759878419,-0.0860465116279069,-0.344480119972314,-0.461722080136402,0.0617977528089887,0.852631578947368,0.00416666666666667,"Destabilising","Destabilising","Stabilising","Destabilising","Stabilising","effect",-0.244,0.225,"6:4","147/150","L:V:C:I:M:A:T",3.74827446550197,2.29709370000913e-15,0.473019029416408,7.92415152964658,18.4724160727947,122.828725767578,1.6278549200979,5.27268754098056e-28,27.2779679641604,16.8169087404394,137.378365631042,1.30826250297363e-39,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERR2707199","ERR2707199","lineage4.3.4.2","cd","Democratic Republic of Congo","pnca_p.cys14arg","A","S","CYS","CA14","pnca_complex.pdb"
|
|
"C14R","L2","PZA","C","C14",14,"R",0,"Pre-XDR","DM","hydrophobic","hydrophilic","neutral","basic","non-polar","pos",8.493,-1.215,-0.333,-1.79171,-2.708,0.11,81,91,0.013,5,5,1,0.0059880239520958,"loop",0.6,5.76,0.0034497628288055,42.4477739726027,42.4477736723918,42.4422996313437,173.445422378416,-58,-18,0,0,-18,0,0,0,0,-4,0,-2,-2,0,0,0,0,-5,0,-2,-3,0,0,-2,-2,-0.307750759878419,-0.0860465116279069,-0.344480119972314,-0.461722080136402,0.0617977528089887,0.852631578947368,0.00416666666666667,"Destabilising","Destabilising","Stabilising","Destabilising","Stabilising","effect",-0.244,0.225,"6:4","147/150","L:V:C:I:M:A:T",3.74827446550197,2.29709370000913e-15,0.473019029416408,7.92415152964658,18.4724160727947,122.828725767578,1.6278549200979,5.27268754098056e-28,27.2779679641604,16.8169087404394,137.378365631042,1.30826250297363e-39,"lineage2","dr_mutations_pyrazinamide","ARG",0,"SAMN07660300","SRR6046243","lineage2.2.1","gb","UK","pnca_p.cys14arg","A","S","CYS","CA14","pnca_complex.pdb"
|
|
"C14R","L2","PZA","C","C14",14,"R",1,"Pre-XDR","DM","hydrophobic","hydrophilic","neutral","basic","non-polar","pos",8.493,-1.215,-0.333,-1.79171,-2.708,0.11,81,91,0.013,5,5,1,0.0059880239520958,"loop",0.6,5.76,0.0034497628288055,42.4477739726027,42.4477736723918,42.4422996313437,173.445422378416,-58,-18,0,0,-18,0,0,0,0,-4,0,-2,-2,0,0,0,0,-5,0,-2,-3,0,0,-2,-2,-0.307750759878419,-0.0860465116279069,-0.344480119972314,-0.461722080136402,0.0617977528089887,0.852631578947368,0.00416666666666667,"Destabilising","Destabilising","Stabilising","Destabilising","Stabilising","effect",-0.244,0.225,"6:4","147/150","L:V:C:I:M:A:T",3.74827446550197,2.29709370000913e-15,0.473019029416408,7.92415152964658,18.4724160727947,122.828725767578,1.6278549200979,5.27268754098056e-28,27.2779679641604,16.8169087404394,137.378365631042,1.30826250297363e-39,"lineage2","dr_mutations_pyrazinamide","ARG",0,"ERR1873498","ERR1873498","lineage2.2.2","za","South Africa","pnca_p.cys14arg","A","S","CYS","CA14","pnca_complex.pdb"
|
|
"C14R","L2","PZA","C","C14",14,"R",1,"XDR","DM","hydrophobic","hydrophilic","neutral","basic","non-polar","pos",8.493,-1.215,-0.333,-1.79171,-2.708,0.11,81,91,0.013,5,5,1,0.0059880239520958,"loop",0.6,5.76,0.0034497628288055,42.4477739726027,42.4477736723918,42.4422996313437,173.445422378416,-58,-18,0,0,-18,0,0,0,0,-4,0,-2,-2,0,0,0,0,-5,0,-2,-3,0,0,-2,-2,-0.307750759878419,-0.0860465116279069,-0.344480119972314,-0.461722080136402,0.0617977528089887,0.852631578947368,0.00416666666666667,"Destabilising","Destabilising","Stabilising","Destabilising","Stabilising","effect",-0.244,0.225,"6:4","147/150","L:V:C:I:M:A:T",3.74827446550197,2.29709370000913e-15,0.473019029416408,7.92415152964658,18.4724160727947,122.828725767578,1.6278549200979,5.27268754098056e-28,27.2779679641604,16.8169087404394,137.378365631042,1.30826250297363e-39,"lineage2","dr_mutations_pyrazinamide","ARG",0,"ERR1873521","ERR1873521","lineage2.2.2","za","South Africa","pnca_p.cys14arg","A","S","CYS","CA14","pnca_complex.pdb"
|
|
"C14R","L2","PZA","C","C14",14,"R",0,"Pre-XDR","DM","hydrophobic","hydrophilic","neutral","basic","non-polar","pos",8.493,-1.215,-0.333,-1.79171,-2.708,0.11,81,91,0.013,5,5,1,0.0059880239520958,"loop",0.6,5.76,0.0034497628288055,42.4477739726027,42.4477736723918,42.4422996313437,173.445422378416,-58,-18,0,0,-18,0,0,0,0,-4,0,-2,-2,0,0,0,0,-5,0,-2,-3,0,0,-2,-2,-0.307750759878419,-0.0860465116279069,-0.344480119972314,-0.461722080136402,0.0617977528089887,0.852631578947368,0.00416666666666667,"Destabilising","Destabilising","Stabilising","Destabilising","Stabilising","effect",-0.244,0.225,"6:4","147/150","L:V:C:I:M:A:T",3.74827446550197,2.29709370000913e-15,0.473019029416408,7.92415152964658,18.4724160727947,122.828725767578,1.6278549200979,5.27268754098056e-28,27.2779679641604,16.8169087404394,137.378365631042,1.30826250297363e-39,"lineage2","dr_mutations_pyrazinamide","ARG",0,"140603310,SAMN05276378","SRR3675285","lineage2.2.1","gb","UK","pnca_p.cys14arg","A","S","CYS","CA14","pnca_complex.pdb"
|
|
"C14R","L3","PZA","C","C14",14,"R",1,"Pre-XDR","DM","hydrophobic","hydrophilic","neutral","basic","non-polar","pos",8.493,-1.215,-0.333,-1.79171,-2.708,0.11,81,91,0.013,5,5,1,0.0059880239520958,"loop",0.6,5.76,0.0034497628288055,42.4477739726027,42.4477736723918,42.4422996313437,173.445422378416,-58,-18,0,0,-18,0,0,0,0,-4,0,-2,-2,0,0,0,0,-5,0,-2,-3,0,0,-2,-2,-0.307750759878419,-0.0860465116279069,-0.344480119972314,-0.461722080136402,0.0617977528089887,0.852631578947368,0.00416666666666667,"Destabilising","Destabilising","Stabilising","Destabilising","Stabilising","effect",-0.244,0.225,"6:4","147/150","L:V:C:I:M:A:T",3.74827446550197,2.29709370000913e-15,0.473019029416408,7.92415152964658,18.4724160727947,122.828725767578,1.6278549200979,5.27268754098056e-28,27.2779679641604,16.8169087404394,137.378365631042,1.30826250297363e-39,"lineage3","dr_mutations_pyrazinamide","ARG",0,"ERR2510647","ERR2510647","lineage3","pk","Pakistan","pnca_p.cys14arg","A","S","CYS","CA14","pnca_complex.pdb"
|
|
"C14R","L2","PZA","C","C14",14,"R",NA,"MDR","DM","hydrophobic","hydrophilic","neutral","basic","non-polar","pos",8.493,-1.215,-0.333,-1.79171,-2.708,0.11,81,91,0.013,5,5,1,0.0059880239520958,"loop",0.6,5.76,0.0034497628288055,42.4477739726027,42.4477736723918,42.4422996313437,173.445422378416,-58,-18,0,0,-18,0,0,0,0,-4,0,-2,-2,0,0,0,0,-5,0,-2,-3,0,0,-2,-2,-0.307750759878419,-0.0860465116279069,-0.344480119972314,-0.461722080136402,0.0617977528089887,0.852631578947368,0.00416666666666667,"Destabilising","Destabilising","Stabilising","Destabilising","Stabilising","effect",-0.244,0.225,"6:4","147/150","L:V:C:I:M:A:T",3.74827446550197,2.29709370000913e-15,0.473019029416408,7.92415152964658,18.4724160727947,122.828725767578,1.6278549200979,5.27268754098056e-28,27.2779679641604,16.8169087404394,137.378365631042,1.30826250297363e-39,"lineage2","dr_mutations_pyrazinamide","ARG",0,"SAMN02403615","SRR1165678_SRR1169247_SRR1165712_SRR1169284","lineage2.2.2","za","South Africa","pnca_p.cys14arg","A","S","CYS","CA14","pnca_complex.pdb"
|
|
"C14R","L2","PZA","C","C14",14,"R",1,"XDR","DM","hydrophobic","hydrophilic","neutral","basic","non-polar","pos",8.493,-1.215,-0.333,-1.79171,-2.708,0.11,81,91,0.013,5,5,1,0.0059880239520958,"loop",0.6,5.76,0.0034497628288055,42.4477739726027,42.4477736723918,42.4422996313437,173.445422378416,-58,-18,0,0,-18,0,0,0,0,-4,0,-2,-2,0,0,0,0,-5,0,-2,-3,0,0,-2,-2,-0.307750759878419,-0.0860465116279069,-0.344480119972314,-0.461722080136402,0.0617977528089887,0.852631578947368,0.00416666666666667,"Destabilising","Destabilising","Stabilising","Destabilising","Stabilising","effect",-0.244,0.225,"6:4","147/150","L:V:C:I:M:A:T",3.74827446550197,2.29709370000913e-15,0.473019029416408,7.92415152964658,18.4724160727947,122.828725767578,1.6278549200979,5.27268754098056e-28,27.2779679641604,16.8169087404394,137.378365631042,1.30826250297363e-39,"lineage2","dr_mutations_pyrazinamide","ARG",0,"ERR1873547","ERR1873547","lineage2.2.2","za","South Africa","pnca_p.cys14arg","A","S","CYS","CA14","pnca_complex.pdb"
|
|
"C14R","L2","PZA","C","C14",14,"R",1,"XDR","DM","hydrophobic","hydrophilic","neutral","basic","non-polar","pos",8.493,-1.215,-0.333,-1.79171,-2.708,0.11,81,91,0.013,5,5,1,0.0059880239520958,"loop",0.6,5.76,0.0034497628288055,42.4477739726027,42.4477736723918,42.4422996313437,173.445422378416,-58,-18,0,0,-18,0,0,0,0,-4,0,-2,-2,0,0,0,0,-5,0,-2,-3,0,0,-2,-2,-0.307750759878419,-0.0860465116279069,-0.344480119972314,-0.461722080136402,0.0617977528089887,0.852631578947368,0.00416666666666667,"Destabilising","Destabilising","Stabilising","Destabilising","Stabilising","effect",-0.244,0.225,"6:4","147/150","L:V:C:I:M:A:T",3.74827446550197,2.29709370000913e-15,0.473019029416408,7.92415152964658,18.4724160727947,122.828725767578,1.6278549200979,5.27268754098056e-28,27.2779679641604,16.8169087404394,137.378365631042,1.30826250297363e-39,"lineage2","dr_mutations_pyrazinamide","ARG",0,"ERR1873466","ERR1873466","lineage2.2.2","za","South Africa","pnca_p.cys14arg","A","S","CYS","CA14","pnca_complex.pdb"
|
|
"C14R","L2","PZA","C","C14",14,"R",1,"Pre-XDR","DM","hydrophobic","hydrophilic","neutral","basic","non-polar","pos",8.493,-1.215,-0.333,-1.79171,-2.708,0.11,81,91,0.013,5,5,1,0.0059880239520958,"loop",0.6,5.76,0.0034497628288055,42.4477739726027,42.4477736723918,42.4422996313437,173.445422378416,-58,-18,0,0,-18,0,0,0,0,-4,0,-2,-2,0,0,0,0,-5,0,-2,-3,0,0,-2,-2,-0.307750759878419,-0.0860465116279069,-0.344480119972314,-0.461722080136402,0.0617977528089887,0.852631578947368,0.00416666666666667,"Destabilising","Destabilising","Stabilising","Destabilising","Stabilising","effect",-0.244,0.225,"6:4","147/150","L:V:C:I:M:A:T",3.74827446550197,2.29709370000913e-15,0.473019029416408,7.92415152964658,18.4724160727947,122.828725767578,1.6278549200979,5.27268754098056e-28,27.2779679641604,16.8169087404394,137.378365631042,1.30826250297363e-39,"lineage2","dr_mutations_pyrazinamide","ARG",0,"ERR1873510","ERR1873510","lineage2.2.2","za","South Africa","pnca_p.cys14arg","A","S","CYS","CA14","pnca_complex.pdb"
|
|
"C14R","L4","PZA","C","C14",14,"R",NA,"Other","DM","hydrophobic","hydrophilic","neutral","basic","non-polar","pos",8.493,-1.215,-0.333,-1.79171,-2.708,0.11,81,91,0.013,5,5,1,0.0059880239520958,"loop",0.6,5.76,0.0034497628288055,42.4477739726027,42.4477736723918,42.4422996313437,173.445422378416,-58,-18,0,0,-18,0,0,0,0,-4,0,-2,-2,0,0,0,0,-5,0,-2,-3,0,0,-2,-2,-0.307750759878419,-0.0860465116279069,-0.344480119972314,-0.461722080136402,0.0617977528089887,0.852631578947368,0.00416666666666667,"Destabilising","Destabilising","Stabilising","Destabilising","Stabilising","effect",-0.244,0.225,"6:4","147/150","L:V:C:I:M:A:T",3.74827446550197,2.29709370000913e-15,0.473019029416408,7.92415152964658,18.4724160727947,122.828725767578,1.6278549200979,5.27268754098056e-28,27.2779679641604,16.8169087404394,137.378365631042,1.30826250297363e-39,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERS3466696","ERR3340724","lineage4.1.1.3","za","","pnca_p.cys14arg","A","S","CYS","CA14","pnca_complex.pdb"
|
|
"C14R","L2","PZA","C","C14",14,"R",1,"XDR","DM","hydrophobic","hydrophilic","neutral","basic","non-polar","pos",8.493,-1.215,-0.333,-1.79171,-2.708,0.11,81,91,0.013,5,5,1,0.0059880239520958,"loop",0.6,5.76,0.0034497628288055,42.4477739726027,42.4477736723918,42.4422996313437,173.445422378416,-58,-18,0,0,-18,0,0,0,0,-4,0,-2,-2,0,0,0,0,-5,0,-2,-3,0,0,-2,-2,-0.307750759878419,-0.0860465116279069,-0.344480119972314,-0.461722080136402,0.0617977528089887,0.852631578947368,0.00416666666666667,"Destabilising","Destabilising","Stabilising","Destabilising","Stabilising","effect",-0.244,0.225,"6:4","147/150","L:V:C:I:M:A:T",3.74827446550197,2.29709370000913e-15,0.473019029416408,7.92415152964658,18.4724160727947,122.828725767578,1.6278549200979,5.27268754098056e-28,27.2779679641604,16.8169087404394,137.378365631042,1.30826250297363e-39,"lineage2","dr_mutations_pyrazinamide","ARG",0,"ERR1873507","ERR1873507","lineage2.2.2","za","South Africa","pnca_p.cys14arg","A","S","CYS","CA14","pnca_complex.pdb"
|
|
"C14R","L2","PZA","C","C14",14,"R",1,"XDR","DM","hydrophobic","hydrophilic","neutral","basic","non-polar","pos",8.493,-1.215,-0.333,-1.79171,-2.708,0.11,81,91,0.013,5,5,1,0.0059880239520958,"loop",0.6,5.76,0.0034497628288055,42.4477739726027,42.4477736723918,42.4422996313437,173.445422378416,-58,-18,0,0,-18,0,0,0,0,-4,0,-2,-2,0,0,0,0,-5,0,-2,-3,0,0,-2,-2,-0.307750759878419,-0.0860465116279069,-0.344480119972314,-0.461722080136402,0.0617977528089887,0.852631578947368,0.00416666666666667,"Destabilising","Destabilising","Stabilising","Destabilising","Stabilising","effect",-0.244,0.225,"6:4","147/150","L:V:C:I:M:A:T",3.74827446550197,2.29709370000913e-15,0.473019029416408,7.92415152964658,18.4724160727947,122.828725767578,1.6278549200979,5.27268754098056e-28,27.2779679641604,16.8169087404394,137.378365631042,1.30826250297363e-39,"lineage2","dr_mutations_pyrazinamide","ARG",0,"ERR1873536","ERR1873536","lineage2.2.2","za","South Africa","pnca_p.cys14arg","A","S","CYS","CA14","pnca_complex.pdb"
|
|
"C14R","L2","PZA","C","C14",14,"R",NA,"XDR","DM","hydrophobic","hydrophilic","neutral","basic","non-polar","pos",8.493,-1.215,-0.333,-1.79171,-2.708,0.11,81,91,0.013,5,5,1,0.0059880239520958,"loop",0.6,5.76,0.0034497628288055,42.4477739726027,42.4477736723918,42.4422996313437,173.445422378416,-58,-18,0,0,-18,0,0,0,0,-4,0,-2,-2,0,0,0,0,-5,0,-2,-3,0,0,-2,-2,-0.307750759878419,-0.0860465116279069,-0.344480119972314,-0.461722080136402,0.0617977528089887,0.852631578947368,0.00416666666666667,"Destabilising","Destabilising","Stabilising","Destabilising","Stabilising","effect",-0.244,0.225,"6:4","147/150","L:V:C:I:M:A:T",3.74827446550197,2.29709370000913e-15,0.473019029416408,7.92415152964658,18.4724160727947,122.828725767578,1.6278549200979,5.27268754098056e-28,27.2779679641604,16.8169087404394,137.378365631042,1.30826250297363e-39,"lineage2","dr_mutations_pyrazinamide","ARG",0,"ERR1034977","ERR1034977","lineage2.2.2","za","South Africa","pnca_p.cys14arg","A","S","CYS","CA14","pnca_complex.pdb"
|
|
"C14R","L2","PZA","C","C14",14,"R",1,"Pre-XDR","DM","hydrophobic","hydrophilic","neutral","basic","non-polar","pos",8.493,-1.215,-0.333,-1.79171,-2.708,0.11,81,91,0.013,5,5,1,0.0059880239520958,"loop",0.6,5.76,0.0034497628288055,42.4477739726027,42.4477736723918,42.4422996313437,173.445422378416,-58,-18,0,0,-18,0,0,0,0,-4,0,-2,-2,0,0,0,0,-5,0,-2,-3,0,0,-2,-2,-0.307750759878419,-0.0860465116279069,-0.344480119972314,-0.461722080136402,0.0617977528089887,0.852631578947368,0.00416666666666667,"Destabilising","Destabilising","Stabilising","Destabilising","Stabilising","effect",-0.244,0.225,"6:4","147/150","L:V:C:I:M:A:T",3.74827446550197,2.29709370000913e-15,0.473019029416408,7.92415152964658,18.4724160727947,122.828725767578,1.6278549200979,5.27268754098056e-28,27.2779679641604,16.8169087404394,137.378365631042,1.30826250297363e-39,"lineage2","dr_mutations_pyrazinamide","ARG",0,"ERR1873533","ERR1873533","lineage2.2.2","za","South Africa","pnca_p.cys14arg","A","S","CYS","CA14","pnca_complex.pdb"
|
|
"C14R","L2","PZA","C","C14",14,"R",1,"XDR","DM","hydrophobic","hydrophilic","neutral","basic","non-polar","pos",8.493,-1.215,-0.333,-1.79171,-2.708,0.11,81,91,0.013,5,5,1,0.0059880239520958,"loop",0.6,5.76,0.0034497628288055,42.4477739726027,42.4477736723918,42.4422996313437,173.445422378416,-58,-18,0,0,-18,0,0,0,0,-4,0,-2,-2,0,0,0,0,-5,0,-2,-3,0,0,-2,-2,-0.307750759878419,-0.0860465116279069,-0.344480119972314,-0.461722080136402,0.0617977528089887,0.852631578947368,0.00416666666666667,"Destabilising","Destabilising","Stabilising","Destabilising","Stabilising","effect",-0.244,0.225,"6:4","147/150","L:V:C:I:M:A:T",3.74827446550197,2.29709370000913e-15,0.473019029416408,7.92415152964658,18.4724160727947,122.828725767578,1.6278549200979,5.27268754098056e-28,27.2779679641604,16.8169087404394,137.378365631042,1.30826250297363e-39,"lineage2","dr_mutations_pyrazinamide","ARG",0,"ERR1873541","ERR1873541","lineage2.2.2","za","South Africa","pnca_p.cys14arg","A","S","CYS","CA14","pnca_complex.pdb"
|
|
"C14R","L2","PZA","C","C14",14,"R",NA,"XDR","DM","hydrophobic","hydrophilic","neutral","basic","non-polar","pos",8.493,-1.215,-0.333,-1.79171,-2.708,0.11,81,91,0.013,5,5,1,0.0059880239520958,"loop",0.6,5.76,0.0034497628288055,42.4477739726027,42.4477736723918,42.4422996313437,173.445422378416,-58,-18,0,0,-18,0,0,0,0,-4,0,-2,-2,0,0,0,0,-5,0,-2,-3,0,0,-2,-2,-0.307750759878419,-0.0860465116279069,-0.344480119972314,-0.461722080136402,0.0617977528089887,0.852631578947368,0.00416666666666667,"Destabilising","Destabilising","Stabilising","Destabilising","Stabilising","effect",-0.244,0.225,"6:4","147/150","L:V:C:I:M:A:T",3.74827446550197,2.29709370000913e-15,0.473019029416408,7.92415152964658,18.4724160727947,122.828725767578,1.6278549200979,5.27268754098056e-28,27.2779679641604,16.8169087404394,137.378365631042,1.30826250297363e-39,"lineage2","dr_mutations_pyrazinamide","ARG",0,"ERR1034995","ERR1034995","lineage2.2.2","za","South Africa","pnca_p.cys14arg","A","S","CYS","CA14","pnca_complex.pdb"
|
|
"C14R","L2","PZA","C","C14",14,"R",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","neutral","basic","non-polar","pos",8.493,-1.215,-0.333,-1.79171,-2.708,0.11,81,91,0.013,5,5,1,0.0059880239520958,"loop",0.6,5.76,0.0034497628288055,42.4477739726027,42.4477736723918,42.4422996313437,173.445422378416,-58,-18,0,0,-18,0,0,0,0,-4,0,-2,-2,0,0,0,0,-5,0,-2,-3,0,0,-2,-2,-0.307750759878419,-0.0860465116279069,-0.344480119972314,-0.461722080136402,0.0617977528089887,0.852631578947368,0.00416666666666667,"Destabilising","Destabilising","Stabilising","Destabilising","Stabilising","effect",-0.244,0.225,"6:4","147/150","L:V:C:I:M:A:T",3.74827446550197,2.29709370000913e-15,0.473019029416408,7.92415152964658,18.4724160727947,122.828725767578,1.6278549200979,5.27268754098056e-28,27.2779679641604,16.8169087404394,137.378365631042,1.30826250297363e-39,"lineage2","dr_mutations_pyrazinamide","ARG",0,"ERR2515519","ERR2515519","lineage2.2.2","za","South Africa","pnca_p.cys14arg","A","S","CYS","CA14","pnca_complex.pdb"
|
|
"C14R","L2","PZA","C","C14",14,"R",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","neutral","basic","non-polar","pos",8.493,-1.215,-0.333,-1.79171,-2.708,0.11,81,91,0.013,5,5,1,0.0059880239520958,"loop",0.6,5.76,0.0034497628288055,42.4477739726027,42.4477736723918,42.4422996313437,173.445422378416,-58,-18,0,0,-18,0,0,0,0,-4,0,-2,-2,0,0,0,0,-5,0,-2,-3,0,0,-2,-2,-0.307750759878419,-0.0860465116279069,-0.344480119972314,-0.461722080136402,0.0617977528089887,0.852631578947368,0.00416666666666667,"Destabilising","Destabilising","Stabilising","Destabilising","Stabilising","effect",-0.244,0.225,"6:4","147/150","L:V:C:I:M:A:T",3.74827446550197,2.29709370000913e-15,0.473019029416408,7.92415152964658,18.4724160727947,122.828725767578,1.6278549200979,5.27268754098056e-28,27.2779679641604,16.8169087404394,137.378365631042,1.30826250297363e-39,"lineage2","dr_mutations_pyrazinamide","ARG",0,"ERR1633796","ERR1633796","lineage2.2.2","za","South Africa","pnca_p.cys14arg","A","S","CYS","CA14","pnca_complex.pdb"
|
|
"C14R","L2","PZA","C","C14",14,"R",1,"XDR","DM","hydrophobic","hydrophilic","neutral","basic","non-polar","pos",8.493,-1.215,-0.333,-1.79171,-2.708,0.11,81,91,0.013,5,5,1,0.0059880239520958,"loop",0.6,5.76,0.0034497628288055,42.4477739726027,42.4477736723918,42.4422996313437,173.445422378416,-58,-18,0,0,-18,0,0,0,0,-4,0,-2,-2,0,0,0,0,-5,0,-2,-3,0,0,-2,-2,-0.307750759878419,-0.0860465116279069,-0.344480119972314,-0.461722080136402,0.0617977528089887,0.852631578947368,0.00416666666666667,"Destabilising","Destabilising","Stabilising","Destabilising","Stabilising","effect",-0.244,0.225,"6:4","147/150","L:V:C:I:M:A:T",3.74827446550197,2.29709370000913e-15,0.473019029416408,7.92415152964658,18.4724160727947,122.828725767578,1.6278549200979,5.27268754098056e-28,27.2779679641604,16.8169087404394,137.378365631042,1.30826250297363e-39,"lineage2","dr_mutations_pyrazinamide","ARG",0,"ERR1873538","ERR1873538","lineage2.2.2","za","South Africa","pnca_p.cys14arg","A","S","CYS","CA14","pnca_complex.pdb"
|
|
"C14R","L2","PZA","C","C14",14,"R",0,"Pre-XDR","DM","hydrophobic","hydrophilic","neutral","basic","non-polar","pos",8.493,-1.215,-0.333,-1.79171,-2.708,0.11,81,91,0.013,5,5,1,0.0059880239520958,"loop",0.6,5.76,0.0034497628288055,42.4477739726027,42.4477736723918,42.4422996313437,173.445422378416,-58,-18,0,0,-18,0,0,0,0,-4,0,-2,-2,0,0,0,0,-5,0,-2,-3,0,0,-2,-2,-0.307750759878419,-0.0860465116279069,-0.344480119972314,-0.461722080136402,0.0617977528089887,0.852631578947368,0.00416666666666667,"Destabilising","Destabilising","Stabilising","Destabilising","Stabilising","effect",-0.244,0.225,"6:4","147/150","L:V:C:I:M:A:T",3.74827446550197,2.29709370000913e-15,0.473019029416408,7.92415152964658,18.4724160727947,122.828725767578,1.6278549200979,5.27268754098056e-28,27.2779679641604,16.8169087404394,137.378365631042,1.30826250297363e-39,"lineage2","dr_mutations_pyrazinamide","ARG",0,"ERR2512930","ERR2512930","lineage2.2.1","gb","UK","pnca_p.cys14arg","A","S","CYS","CA14","pnca_complex.pdb"
|
|
"C14R","L2","PZA","C","C14",14,"R",NA,"XDR","DM","hydrophobic","hydrophilic","neutral","basic","non-polar","pos",8.493,-1.215,-0.333,-1.79171,-2.708,0.11,81,91,0.013,5,5,1,0.0059880239520958,"loop",0.6,5.76,0.0034497628288055,42.4477739726027,42.4477736723918,42.4422996313437,173.445422378416,-58,-18,0,0,-18,0,0,0,0,-4,0,-2,-2,0,0,0,0,-5,0,-2,-3,0,0,-2,-2,-0.307750759878419,-0.0860465116279069,-0.344480119972314,-0.461722080136402,0.0617977528089887,0.852631578947368,0.00416666666666667,"Destabilising","Destabilising","Stabilising","Destabilising","Stabilising","effect",-0.244,0.225,"6:4","147/150","L:V:C:I:M:A:T",3.74827446550197,2.29709370000913e-15,0.473019029416408,7.92415152964658,18.4724160727947,122.828725767578,1.6278549200979,5.27268754098056e-28,27.2779679641604,16.8169087404394,137.378365631042,1.30826250297363e-39,"lineage2","dr_mutations_pyrazinamide","ARG",0,"ERR2515725","ERR2515725","lineage2.2.2","za","South Africa","pnca_p.cys14arg","A","S","CYS","CA14","pnca_complex.pdb"
|
|
"C14R","L2","PZA","C","C14",14,"R",1,"XDR","DM","hydrophobic","hydrophilic","neutral","basic","non-polar","pos",8.493,-1.215,-0.333,-1.79171,-2.708,0.11,81,91,0.013,5,5,1,0.0059880239520958,"loop",0.6,5.76,0.0034497628288055,42.4477739726027,42.4477736723918,42.4422996313437,173.445422378416,-58,-18,0,0,-18,0,0,0,0,-4,0,-2,-2,0,0,0,0,-5,0,-2,-3,0,0,-2,-2,-0.307750759878419,-0.0860465116279069,-0.344480119972314,-0.461722080136402,0.0617977528089887,0.852631578947368,0.00416666666666667,"Destabilising","Destabilising","Stabilising","Destabilising","Stabilising","effect",-0.244,0.225,"6:4","147/150","L:V:C:I:M:A:T",3.74827446550197,2.29709370000913e-15,0.473019029416408,7.92415152964658,18.4724160727947,122.828725767578,1.6278549200979,5.27268754098056e-28,27.2779679641604,16.8169087404394,137.378365631042,1.30826250297363e-39,"lineage2","dr_mutations_pyrazinamide","ARG",0,"ERR2515684","ERR2515684","lineage2.2.2","za","South Africa","pnca_p.cys14arg","A","S","CYS","CA14","pnca_complex.pdb"
|
|
"C14R","L2","PZA","C","C14",14,"R",1,"XDR","DM","hydrophobic","hydrophilic","neutral","basic","non-polar","pos",8.493,-1.215,-0.333,-1.79171,-2.708,0.11,81,91,0.013,5,5,1,0.0059880239520958,"loop",0.6,5.76,0.0034497628288055,42.4477739726027,42.4477736723918,42.4422996313437,173.445422378416,-58,-18,0,0,-18,0,0,0,0,-4,0,-2,-2,0,0,0,0,-5,0,-2,-3,0,0,-2,-2,-0.307750759878419,-0.0860465116279069,-0.344480119972314,-0.461722080136402,0.0617977528089887,0.852631578947368,0.00416666666666667,"Destabilising","Destabilising","Stabilising","Destabilising","Stabilising","effect",-0.244,0.225,"6:4","147/150","L:V:C:I:M:A:T",3.74827446550197,2.29709370000913e-15,0.473019029416408,7.92415152964658,18.4724160727947,122.828725767578,1.6278549200979,5.27268754098056e-28,27.2779679641604,16.8169087404394,137.378365631042,1.30826250297363e-39,"lineage2","dr_mutations_pyrazinamide","ARG",0,"ERR1873460","ERR1873460","lineage2.2.2","za","South Africa","pnca_p.cys14arg","A","S","CYS","CA14","pnca_complex.pdb"
|
|
"C14W","L2","PZA","C","C14",14,"W",1,"XDR","DM","hydrophobic","hydrophobic","neutral","non-polar","non-polar","non-polar",8.493,-0.421,-1.426,3.56718,-1.443,-1.01,81,91,0.013,5,5,1,0.0059880239520958,"loop",0.6,5.76,0.0002156101768003,9.70466975178797,9.70465898653051,9.70194990589383,2.29168245016684,-40,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-2,0,-2,-4,0,0,0,-2,-0.106636271529888,-0.368475452196382,0.129924460405452,-0.246035805626598,-0.264397905759162,0.852631578947368,0.00416666666666667,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.244,0.225,"6:4","147/150","L:V:C:I:M:A:T",2.27260607808817,0.0634455902260898,1.22442760158496,1.8560559033024,0.929172866365548,208.881603004778,0.986980761010679,0.0776844925942494,1.10966566656461,0.504888890842109,570.372842410328,0.130068862702538,"lineage2","dr_mutations_pyrazinamide","TRP",0,"ERR1873469","ERR1873469","lineage2.2.1","za","South Africa","pnca_p.cys14trp","A","S","CYS","CA14","pnca_complex.pdb"
|
|
"C14W","L4","PZA","C","C14",14,"W",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","neutral","non-polar","non-polar","non-polar",8.493,-0.421,-1.426,3.56718,-1.443,-1.01,81,91,0.013,5,5,1,0.0059880239520958,"loop",0.6,5.76,0.0002156101768003,9.70466975178797,9.70465898653051,9.70194990589383,2.29168245016684,-40,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-2,0,-2,-4,0,0,0,-2,-0.106636271529888,-0.368475452196382,0.129924460405452,-0.246035805626598,-0.264397905759162,0.852631578947368,0.00416666666666667,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.244,0.225,"6:4","147/150","L:V:C:I:M:A:T",2.27260607808817,0.0634455902260898,1.22442760158496,1.8560559033024,0.929172866365548,208.881603004778,0.986980761010679,0.0776844925942494,1.10966566656461,0.504888890842109,570.372842410328,0.130068862702538,"lineage4","dr_mutations_pyrazinamide","TRP",0,"SAMN02584604","SRR1169173_SRR1166331","lineage4.2.1","md","Moldova","pnca_p.cys14trp","A","S","CYS","CA14","pnca_complex.pdb"
|
|
"C14W","L4","PZA","C","C14",14,"W",0,"MDR","DM","hydrophobic","hydrophobic","neutral","non-polar","non-polar","non-polar",8.493,-0.421,-1.426,3.56718,-1.443,-1.01,81,91,0.013,5,5,1,0.0059880239520958,"loop",0.6,5.76,0.0002156101768003,9.70466975178797,9.70465898653051,9.70194990589383,2.29168245016684,-40,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-2,0,-2,-4,0,0,0,-2,-0.106636271529888,-0.368475452196382,0.129924460405452,-0.246035805626598,-0.264397905759162,0.852631578947368,0.00416666666666667,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.244,0.225,"6:4","147/150","L:V:C:I:M:A:T",2.27260607808817,0.0634455902260898,1.22442760158496,1.8560559033024,0.929172866365548,208.881603004778,0.986980761010679,0.0776844925942494,1.10966566656461,0.504888890842109,570.372842410328,0.130068862702538,"lineage4","dr_mutations_pyrazinamide","TRP",0,"SRR6339661","SRR6339661","lineage4.3.3","au","Australia","pnca_p.cys14trp","A","S","CYS","CA14","pnca_complex.pdb"
|
|
"C14W","L4","PZA","C","C14",14,"W",NA,"MDR","DM","hydrophobic","hydrophobic","neutral","non-polar","non-polar","non-polar",8.493,-0.421,-1.426,3.56718,-1.443,-1.01,81,91,0.013,5,5,1,0.0059880239520958,"loop",0.6,5.76,0.0002156101768003,9.70466975178797,9.70465898653051,9.70194990589383,2.29168245016684,-40,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-2,0,-2,-4,0,0,0,-2,-0.106636271529888,-0.368475452196382,0.129924460405452,-0.246035805626598,-0.264397905759162,0.852631578947368,0.00416666666666667,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.244,0.225,"6:4","147/150","L:V:C:I:M:A:T",2.27260607808817,0.0634455902260898,1.22442760158496,1.8560559033024,0.929172866365548,208.881603004778,0.986980761010679,0.0776844925942494,1.10966566656461,0.504888890842109,570.372842410328,0.130068862702538,"lineage4","dr_mutations_pyrazinamide","TRP",0,"SAMN02403605","SRR1165661_SRR1167387_SRR1169131_SRR1172082","lineage4.3.3","za","South Africa","pnca_p.cys14trp","A","S","CYS","CA14","pnca_complex.pdb"
|
|
"C14W","L4","PZA","C","C14",14,"W",NA,"MDR","DM","hydrophobic","hydrophobic","neutral","non-polar","non-polar","non-polar",8.493,-0.421,-1.426,3.56718,-1.443,-1.01,81,91,0.013,5,5,1,0.0059880239520958,"loop",0.6,5.76,0.0002156101768003,9.70466975178797,9.70465898653051,9.70194990589383,2.29168245016684,-40,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-2,0,-2,-4,0,0,0,-2,-0.106636271529888,-0.368475452196382,0.129924460405452,-0.246035805626598,-0.264397905759162,0.852631578947368,0.00416666666666667,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.244,0.225,"6:4","147/150","L:V:C:I:M:A:T",2.27260607808817,0.0634455902260898,1.22442760158496,1.8560559033024,0.929172866365548,208.881603004778,0.986980761010679,0.0776844925942494,1.10966566656461,0.504888890842109,570.372842410328,0.130068862702538,"lineage4","dr_mutations_pyrazinamide","TRP",0,"SRR7517681","SRR7517681","lineage4.1","ci","Ivory_Coast","pnca_p.cys14trp","A","S","CYS","CA14","pnca_complex.pdb"
|
|
"C14W","L2","PZA","C","C14",14,"W",1,"MDR","DM","hydrophobic","hydrophobic","neutral","non-polar","non-polar","non-polar",8.493,-0.421,-1.426,3.56718,-1.443,-1.01,81,91,0.013,5,5,1,0.0059880239520958,"loop",0.6,5.76,0.0002156101768003,9.70466975178797,9.70465898653051,9.70194990589383,2.29168245016684,-40,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-2,0,-2,-4,0,0,0,-2,-0.106636271529888,-0.368475452196382,0.129924460405452,-0.246035805626598,-0.264397905759162,0.852631578947368,0.00416666666666667,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.244,0.225,"6:4","147/150","L:V:C:I:M:A:T",2.27260607808817,0.0634455902260898,1.22442760158496,1.8560559033024,0.929172866365548,208.881603004778,0.986980761010679,0.0776844925942494,1.10966566656461,0.504888890842109,570.372842410328,0.130068862702538,"lineage2","dr_mutations_pyrazinamide","TRP",0,"SAMN10961307","SRR8651560","lineage2.2.1","cn","China:Wenzhou","pnca_p.cys14trp","A","S","CYS","CA14","pnca_complex.pdb"
|
|
"C14W","L4","PZA","C","C14",14,"W",NA,"MDR","DM","hydrophobic","hydrophobic","neutral","non-polar","non-polar","non-polar",8.493,-0.421,-1.426,3.56718,-1.443,-1.01,81,91,0.013,5,5,1,0.0059880239520958,"loop",0.6,5.76,0.0002156101768003,9.70466975178797,9.70465898653051,9.70194990589383,2.29168245016684,-40,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-2,0,-2,-4,0,0,0,-2,-0.106636271529888,-0.368475452196382,0.129924460405452,-0.246035805626598,-0.264397905759162,0.852631578947368,0.00416666666666667,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.244,0.225,"6:4","147/150","L:V:C:I:M:A:T",2.27260607808817,0.0634455902260898,1.22442760158496,1.8560559033024,0.929172866365548,208.881603004778,0.986980761010679,0.0776844925942494,1.10966566656461,0.504888890842109,570.372842410328,0.130068862702538,"lineage4","dr_mutations_pyrazinamide","TRP",0,"SAMN02403604","SRR1165710_SRR1169206_SRR1165682_SRR1172152","lineage4.3.3","za","South Africa","pnca_p.cys14trp","A","S","CYS","CA14","pnca_complex.pdb"
|
|
"C14Y","L2","PZA","C","C14",14,"Y",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","neutral","neutral","non-polar","polar",8.493,-0.604,-0.931,-0.852908,-1.613,-0.51,73,85,0.013,5,5,1,0.0059880239520958,"loop",0.6,5.76,0.0001437401178668,4.85029436501262,4.85029432717734,4.84956447904112,0.0881192621863332,-40,-2,0,0,-2,0,0,0,0,0,0,0,0,0,0,0,0,-5,0,-3,-2,0,0,0,-2,-0.152988855116515,-0.240568475452196,-0.163982927016842,-0.275021312872975,-0.133507853403141,0.768421052631579,0.00416666666666667,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.244,0.225,"6:4","147/150","L:V:C:I:M:A:T",1.57903938912402,0.264247566376723,1.41439286276584,1.11640791656443,0.191756076673665,122.683760399245,0.685768096792206,0.312734154310187,0.504824686014995,0.061763864579114,379.558337204203,0.766581879696361,"lineage2","dr_mutations_pyrazinamide","TYR",0,"SRR5709803,SAMN07236302","SRR5709803","lineage2.2.2","th","Thailand","pnca_p.cys14tyr","A","S","CYS","CA14","pnca_complex.pdb"
|
|
"C14Y","L2","PZA","C","C14",14,"Y",0,"MDR","DM","hydrophobic","hydrophobic","neutral","neutral","non-polar","polar",8.493,-0.604,-0.931,-0.852908,-1.613,-0.51,73,85,0.013,5,5,1,0.0059880239520958,"loop",0.6,5.76,0.0001437401178668,4.85029436501262,4.85029432717734,4.84956447904112,0.0881192621863332,-40,-2,0,0,-2,0,0,0,0,0,0,0,0,0,0,0,0,-5,0,-3,-2,0,0,0,-2,-0.152988855116515,-0.240568475452196,-0.163982927016842,-0.275021312872975,-0.133507853403141,0.768421052631579,0.00416666666666667,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.244,0.225,"6:4","147/150","L:V:C:I:M:A:T",1.57903938912402,0.264247566376723,1.41439286276584,1.11640791656443,0.191756076673665,122.683760399245,0.685768096792206,0.312734154310187,0.504824686014995,0.061763864579114,379.558337204203,0.766581879696361,"lineage2","dr_mutations_pyrazinamide","TYR",0,"ERS458014","ERR552384_ERR552383","lineage2.2.1","uz","Nukus","pnca_p.cys14tyr","A","S","CYS","CA14","pnca_complex.pdb"
|
|
"C14Y","L2","PZA","C","C14",14,"Y",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","neutral","neutral","non-polar","polar",8.493,-0.604,-0.931,-0.852908,-1.613,-0.51,73,85,0.013,5,5,1,0.0059880239520958,"loop",0.6,5.76,0.0001437401178668,4.85029436501262,4.85029432717734,4.84956447904112,0.0881192621863332,-40,-2,0,0,-2,0,0,0,0,0,0,0,0,0,0,0,0,-5,0,-3,-2,0,0,0,-2,-0.152988855116515,-0.240568475452196,-0.163982927016842,-0.275021312872975,-0.133507853403141,0.768421052631579,0.00416666666666667,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.244,0.225,"6:4","147/150","L:V:C:I:M:A:T",1.57903938912402,0.264247566376723,1.41439286276584,1.11640791656443,0.191756076673665,122.683760399245,0.685768096792206,0.312734154310187,0.504824686014995,0.061763864579114,379.558337204203,0.766581879696361,"lineage2","dr_mutations_pyrazinamide","TYR",0,"SRR5709759,SAMN07236273","SRR5709759","lineage2.2.2","th","Thailand","pnca_p.cys14tyr","A","S","CYS","CA14","pnca_complex.pdb"
|
|
"C14Y","L2","PZA","C","C14",14,"Y",1,"Pre-XDR","DM","hydrophobic","hydrophobic","neutral","neutral","non-polar","polar",8.493,-0.604,-0.931,-0.852908,-1.613,-0.51,73,85,0.013,5,5,1,0.0059880239520958,"loop",0.6,5.76,0.0001437401178668,4.85029436501262,4.85029432717734,4.84956447904112,0.0881192621863332,-40,-2,0,0,-2,0,0,0,0,0,0,0,0,0,0,0,0,-5,0,-3,-2,0,0,0,-2,-0.152988855116515,-0.240568475452196,-0.163982927016842,-0.275021312872975,-0.133507853403141,0.768421052631579,0.00416666666666667,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.244,0.225,"6:4","147/150","L:V:C:I:M:A:T",1.57903938912402,0.264247566376723,1.41439286276584,1.11640791656443,0.191756076673665,122.683760399245,0.685768096792206,0.312734154310187,0.504824686014995,0.061763864579114,379.558337204203,0.766581879696361,"lineage2","dr_mutations_pyrazinamide","TYR",0,"MDR_19466","SRR6824286","lineage2.2.1","cn","China: Chaoan County, Chaozhou City, Guangdong Province","pnca_p.cys14tyr","A","S","CYS","CA14","pnca_complex.pdb"
|
|
"C14Y","L2","PZA","C","C14",14,"Y",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","neutral","neutral","non-polar","polar",8.493,-0.604,-0.931,-0.852908,-1.613,-0.51,73,85,0.013,5,5,1,0.0059880239520958,"loop",0.6,5.76,0.0001437401178668,4.85029436501262,4.85029432717734,4.84956447904112,0.0881192621863332,-40,-2,0,0,-2,0,0,0,0,0,0,0,0,0,0,0,0,-5,0,-3,-2,0,0,0,-2,-0.152988855116515,-0.240568475452196,-0.163982927016842,-0.275021312872975,-0.133507853403141,0.768421052631579,0.00416666666666667,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.244,0.225,"6:4","147/150","L:V:C:I:M:A:T",1.57903938912402,0.264247566376723,1.41439286276584,1.11640791656443,0.191756076673665,122.683760399245,0.685768096792206,0.312734154310187,0.504824686014995,0.061763864579114,379.558337204203,0.766581879696361,"lineage2","dr_mutations_pyrazinamide","TYR",0,"SRS935931,SAMN03653306","SRR2024888","lineage2.2.1","cn","China","pnca_p.cys14tyr","A","S","CYS","CA14","pnca_complex.pdb"
|
|
"C14Y","L2","PZA","C","C14",14,"Y",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","neutral","neutral","non-polar","polar",8.493,-0.604,-0.931,-0.852908,-1.613,-0.51,73,85,0.013,5,5,1,0.0059880239520958,"loop",0.6,5.76,0.0001437401178668,4.85029436501262,4.85029432717734,4.84956447904112,0.0881192621863332,-40,-2,0,0,-2,0,0,0,0,0,0,0,0,0,0,0,0,-5,0,-3,-2,0,0,0,-2,-0.152988855116515,-0.240568475452196,-0.163982927016842,-0.275021312872975,-0.133507853403141,0.768421052631579,0.00416666666666667,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.244,0.225,"6:4","147/150","L:V:C:I:M:A:T",1.57903938912402,0.264247566376723,1.41439286276584,1.11640791656443,0.191756076673665,122.683760399245,0.685768096792206,0.312734154310187,0.504824686014995,0.061763864579114,379.558337204203,0.766581879696361,"lineage2","dr_mutations_pyrazinamide","TYR",0,"SAMN07236536,SRR5709960","SRR5709960","lineage2.2.2","th","Thailand","pnca_p.cys14tyr","A","S","CYS","CA14","pnca_complex.pdb"
|
|
"C14Y","L2","PZA","C","C14",14,"Y",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","neutral","neutral","non-polar","polar",8.493,-0.604,-0.931,-0.852908,-1.613,-0.51,73,85,0.013,5,5,1,0.0059880239520958,"loop",0.6,5.76,0.0001437401178668,4.85029436501262,4.85029432717734,4.84956447904112,0.0881192621863332,-40,-2,0,0,-2,0,0,0,0,0,0,0,0,0,0,0,0,-5,0,-3,-2,0,0,0,-2,-0.152988855116515,-0.240568475452196,-0.163982927016842,-0.275021312872975,-0.133507853403141,0.768421052631579,0.00416666666666667,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.244,0.225,"6:4","147/150","L:V:C:I:M:A:T",1.57903938912402,0.264247566376723,1.41439286276584,1.11640791656443,0.191756076673665,122.683760399245,0.685768096792206,0.312734154310187,0.504824686014995,0.061763864579114,379.558337204203,0.766581879696361,"lineage2","dr_mutations_pyrazinamide","TYR",0,"SRS797216","SRR1723739","lineage2.2.1","cn","China:Guangdong","pnca_p.cys14tyr","A","S","CYS","CA14","pnca_complex.pdb"
|
|
"E15D","L4","PZA","E","E15",15,"D",NA,"Sensitive","OM","hydrophilic","hydrophilic","acidic","acidic","neg","neg",11.854,0.146,-0.135,2.38936,-0.543,-0.05,-31,66,-0.898,8,8,92,0.412556053811659,"loop",-0.466666666666667,3.7,NA,NA,NA,NA,NA,10,4,0,0,4,0,0,0,0,7,0,7,0,0,0,0,0,4,0,2,2,0,0,2,-4,0.0654708520179372,-0.0348837209302325,0.0870256922034688,-0.0925831202046036,-0.013089005235602,-0.333333333333333,-0.739703459637562,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","neutral",-0.993,-0.827,"9:8","146/150","H:A:S:E:P:D",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage4","other_mutations_pyrazinamide","ASP",0,"ERR2229487","ERR2229487","lineage4.8","dk","","pnca_p.glu15asp","A","T","GLU","EA15","pnca_complex.pdb"
|
|
"E15G","L2;L4","PZA","E","E15",15,"G",0,"MDR","OM","hydrophilic","hydrophobic","acidic","neutral","neg","non-polar",11.854,-0.81,0.063,2.82636,-0.925,0.47,66,80,-0.898,8,8,92,0.412556053811659,"loop",-0.466666666666667,3.7,0.0003593502946672,0.484657419083649,1.69068633684896e-05,0,0.177777263899814,16,10,0,0,10,0,0,0,0,7,0,7,0,0,0,0,0,4,0,2,2,0,0,11,5,-0.20516717325228,0.0535714285714285,0.102942183436651,-0.15771526001705,0.264044943820225,0.694736842105263,-0.739703459637562,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-0.993,-0.827,"9:8","146/150","H:A:S:E:P:D",-10.9877909019995,0.939691219428539,145.22979768191,-0.075657964669658,NA,60.3389082676129,-0.314565134742567,0.596111875058711,0.224672226566594,0,5.29224350433385,0.673290424524484,"lineage2;lineage4","other_mutations_pyrazinamide","GLY",0,"14MT_11622","SRR5525995","lineage4.9;lineage2.2.1.1","pg","","pnca_p.glu15gly","A","T","GLU","EA15","pnca_complex.pdb"
|
|
"E15G","L2","PZA","E","E15",15,"G",0,"XDR","OM","hydrophilic","hydrophobic","acidic","neutral","neg","non-polar",11.854,-0.81,0.063,2.82636,-0.925,0.47,66,80,-0.898,8,8,92,0.412556053811659,"loop",-0.466666666666667,3.7,0.0003593502946672,0.484657419083649,1.69068633684896e-05,0,0.177777263899814,16,10,0,0,10,0,0,0,0,7,0,7,0,0,0,0,0,4,0,2,2,0,0,11,5,-0.20516717325228,0.0535714285714285,0.102942183436651,-0.15771526001705,0.264044943820225,0.694736842105263,-0.739703459637562,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-0.993,-0.827,"9:8","146/150","H:A:S:E:P:D",-10.9877909019995,0.939691219428539,145.22979768191,-0.075657964669658,NA,60.3389082676129,-0.314565134742567,0.596111875058711,0.224672226566594,0,5.29224350433385,0.673290424524484,"lineage2","other_mutations_pyrazinamide","GLY",0,"ERR2510693","ERR2510693","lineage2.2.1","it","Italy","pnca_p.glu15gly","A","T","GLU","EA15","pnca_complex.pdb"
|
|
"E15G","L2","PZA","E","E15",15,"G",0,"XDR","OM","hydrophilic","hydrophobic","acidic","neutral","neg","non-polar",11.854,-0.81,0.063,2.82636,-0.925,0.47,66,80,-0.898,8,8,92,0.412556053811659,"loop",-0.466666666666667,3.7,0.0003593502946672,0.484657419083649,1.69068633684896e-05,0,0.177777263899814,16,10,0,0,10,0,0,0,0,7,0,7,0,0,0,0,0,4,0,2,2,0,0,11,5,-0.20516717325228,0.0535714285714285,0.102942183436651,-0.15771526001705,0.264044943820225,0.694736842105263,-0.739703459637562,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-0.993,-0.827,"9:8","146/150","H:A:S:E:P:D",-10.9877909019995,0.939691219428539,145.22979768191,-0.075657964669658,NA,60.3389082676129,-0.314565134742567,0.596111875058711,0.224672226566594,0,5.29224350433385,0.673290424524484,"lineage2","other_mutations_pyrazinamide","GLY",0,"ERR2510694","ERR2510694","lineage2.2.1","it","Italy","pnca_p.glu15gly","A","T","GLU","EA15","pnca_complex.pdb"
|
|
"E15G","L2","PZA","E","E15",15,"G",0,"XDR","OM","hydrophilic","hydrophobic","acidic","neutral","neg","non-polar",11.854,-0.81,0.063,2.82636,-0.925,0.47,66,80,-0.898,8,8,92,0.412556053811659,"loop",-0.466666666666667,3.7,0.0003593502946672,0.484657419083649,1.69068633684896e-05,0,0.177777263899814,16,10,0,0,10,0,0,0,0,7,0,7,0,0,0,0,0,4,0,2,2,0,0,11,5,-0.20516717325228,0.0535714285714285,0.102942183436651,-0.15771526001705,0.264044943820225,0.694736842105263,-0.739703459637562,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-0.993,-0.827,"9:8","146/150","H:A:S:E:P:D",-10.9877909019995,0.939691219428539,145.22979768191,-0.075657964669658,NA,60.3389082676129,-0.314565134742567,0.596111875058711,0.224672226566594,0,5.29224350433385,0.673290424524484,"lineage2","other_mutations_pyrazinamide","GLY",0,"ERR2510849","ERR2510849","lineage2.2.1","it","Italy","pnca_p.glu15gly","A","T","GLU","EA15","pnca_complex.pdb"
|
|
"E15G","L2","PZA","E","E15",15,"G",0,"XDR","OM","hydrophilic","hydrophobic","acidic","neutral","neg","non-polar",11.854,-0.81,0.063,2.82636,-0.925,0.47,66,80,-0.898,8,8,92,0.412556053811659,"loop",-0.466666666666667,3.7,0.0003593502946672,0.484657419083649,1.69068633684896e-05,0,0.177777263899814,16,10,0,0,10,0,0,0,0,7,0,7,0,0,0,0,0,4,0,2,2,0,0,11,5,-0.20516717325228,0.0535714285714285,0.102942183436651,-0.15771526001705,0.264044943820225,0.694736842105263,-0.739703459637562,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-0.993,-0.827,"9:8","146/150","H:A:S:E:P:D",-10.9877909019995,0.939691219428539,145.22979768191,-0.075657964669658,NA,60.3389082676129,-0.314565134742567,0.596111875058711,0.224672226566594,0,5.29224350433385,0.673290424524484,"lineage2","other_mutations_pyrazinamide","GLY",0,"ERR1873438","ERR1873438","lineage2.2.1","za","South Africa","pnca_p.glu15gly","A","T","GLU","EA15","pnca_complex.pdb"
|
|
"E15G","L2","PZA","E","E15",15,"G",NA,"Pre-XDR","OM","hydrophilic","hydrophobic","acidic","neutral","neg","non-polar",11.854,-0.81,0.063,2.82636,-0.925,0.47,66,80,-0.898,8,8,92,0.412556053811659,"loop",-0.466666666666667,3.7,0.0003593502946672,0.484657419083649,1.69068633684896e-05,0,0.177777263899814,16,10,0,0,10,0,0,0,0,7,0,7,0,0,0,0,0,4,0,2,2,0,0,11,5,-0.20516717325228,0.0535714285714285,0.102942183436651,-0.15771526001705,0.264044943820225,0.694736842105263,-0.739703459637562,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-0.993,-0.827,"9:8","146/150","H:A:S:E:P:D",-10.9877909019995,0.939691219428539,145.22979768191,-0.075657964669658,NA,60.3389082676129,-0.314565134742567,0.596111875058711,0.224672226566594,0,5.29224350433385,0.673290424524484,"lineage2","other_mutations_pyrazinamide","GLY",0,"SRR5709843,SAMN07236389","SRR5709843","lineage2.2.1","th","Thailand","pnca_p.glu15gly","A","T","GLU","EA15","pnca_complex.pdb"
|
|
"G17A","L2","PZA","G","G17",17,"A",NA,"MDR","OM","hydrophobic","hydrophobic","neutral","non-polar","non-polar","non-polar",11.288,-0.016,-0.03,4.40656,-1.942,-0.17,66,80,-1.147,9,9,18,0.173076923076923,"loop",-0.533333333333333,3.87,7.18700589334483e-05,9.70142977291842,188179.926264583,Inf,0.763784339928386,-6,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,-2,0,-4,2,-6,0,-13,-18,-0.0040526849037487,-0.0077519379844961,0.160496507113251,-0.331116794543905,-0.0445026178010471,0.694736842105263,-0.944810543657331,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.124,"9:9","147/150","R:G",12.1451538387262,0.919026337424224,119.468044436215,0.101660271548268,5.01153666064308e-06,NA,0.986835744238421,0.170978870202674,0.767057556984365,0.124324963210678,Inf,0.382146811758261,"lineage2","other_mutations_pyrazinamide","ALA",0,"ERR718273","ERR718273","lineage2.2.1","th","Thailand","pnca_p.gly17ala","A","S","GLY","GA17","pnca_complex.pdb"
|
|
"G17A","L4","PZA","G","G17",17,"A",1,"Pre-MDR","OM","hydrophobic","hydrophobic","neutral","non-polar","non-polar","non-polar",11.288,-0.016,-0.03,4.40656,-1.942,-0.17,66,80,-1.147,9,9,18,0.173076923076923,"loop",-0.533333333333333,3.87,7.18700589334483e-05,9.70142977291842,188179.926264583,Inf,0.763784339928386,-6,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,-2,0,-4,2,-6,0,-13,-18,-0.0040526849037487,-0.0077519379844961,0.160496507113251,-0.331116794543905,-0.0445026178010471,0.694736842105263,-0.944810543657331,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.124,"9:9","147/150","R:G",12.1451538387262,0.919026337424224,119.468044436215,0.101660271548268,5.01153666064308e-06,NA,0.986835744238421,0.170978870202674,0.767057556984365,0.124324963210678,Inf,0.382146811758261,"lineage4","other_mutations_pyrazinamide","ALA",0,"ERR2200070","ERR2200070","lineage4.4.1.1","rs","Serbia","pnca_p.gly17ala","A","S","GLY","GA17","pnca_complex.pdb"
|
|
"G17D","L4","PZA","G","G17",17,"D",NA,"MDR","DM","hydrophobic","hydrophilic","neutral","acidic","non-polar","neg",11.288,1.678,-0.552,15.5901,-2.984,-0.05,78,85,-1.147,9,9,18,0.173076923076923,"loop",-0.533333333333333,3.87,0.0003593502946672,19.4256842105263,19.4256680571767,19.4169790983636,9.87561363723508,-26,-26,0,0,-26,0,0,0,0,-2,0,-4,-2,0,0,0,0,-6,0,-6,-2,-6,0,-11,-21,0.752466367713005,-0.142635658914729,0.567825377515862,-0.508780903665814,-0.013089005235602,0.821052631578947,-0.944810543657331,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.124,"9:9","147/150","R:G",2.96659528728018,0.0079500503166054,1.11770528264822,2.65418382943607,2.87215213651461,380.0971589756,1.28837632444196,0.0036816889015929,2.43395291165754,1.92061868691892,951.403114304703,0.0016748373055023,"lineage4","dr_mutations_pyrazinamide","ASP",0,"ERR1035344","ERR1035344","lineage4.3.2","br","Brazil","pnca_p.gly17asp","A","S","GLY","GA17","pnca_complex.pdb"
|
|
"G17D","L4","PZA","G","G17",17,"D",1,"MDR","DM","hydrophobic","hydrophilic","neutral","acidic","non-polar","neg",11.288,1.678,-0.552,15.5901,-2.984,-0.05,78,85,-1.147,9,9,18,0.173076923076923,"loop",-0.533333333333333,3.87,0.0003593502946672,19.4256842105263,19.4256680571767,19.4169790983636,9.87561363723508,-26,-26,0,0,-26,0,0,0,0,-2,0,-4,-2,0,0,0,0,-6,0,-6,-2,-6,0,-11,-21,0.752466367713005,-0.142635658914729,0.567825377515862,-0.508780903665814,-0.013089005235602,0.821052631578947,-0.944810543657331,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.124,"9:9","147/150","R:G",2.96659528728018,0.0079500503166054,1.11770528264822,2.65418382943607,2.87215213651461,380.0971589756,1.28837632444196,0.0036816889015929,2.43395291165754,1.92061868691892,951.403114304703,0.0016748373055023,"lineage4","dr_mutations_pyrazinamide","ASP",0,"ERR040115","ERR040115","lineage4.1.1.3","ug","Uganda","pnca_p.gly17asp","A","S","GLY","GA17","pnca_complex.pdb"
|
|
"G17D","L4","PZA","G","G17",17,"D",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","neutral","acidic","non-polar","neg",11.288,1.678,-0.552,15.5901,-2.984,-0.05,78,85,-1.147,9,9,18,0.173076923076923,"loop",-0.533333333333333,3.87,0.0003593502946672,19.4256842105263,19.4256680571767,19.4169790983636,9.87561363723508,-26,-26,0,0,-26,0,0,0,0,-2,0,-4,-2,0,0,0,0,-6,0,-6,-2,-6,0,-11,-21,0.752466367713005,-0.142635658914729,0.567825377515862,-0.508780903665814,-0.013089005235602,0.821052631578947,-0.944810543657331,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.124,"9:9","147/150","R:G",2.96659528728018,0.0079500503166054,1.11770528264822,2.65418382943607,2.87215213651461,380.0971589756,1.28837632444196,0.0036816889015929,2.43395291165754,1.92061868691892,951.403114304703,0.0016748373055023,"lineage4","dr_mutations_pyrazinamide","ASP",0,"SRR7341699","SRR7341699","lineage4.4.1.1","ro","Romania","pnca_p.gly17asp","A","S","GLY","GA17","pnca_complex.pdb"
|
|
"G17D","L4","PZA","G","G17",17,"D",NA,"MDR","DM","hydrophobic","hydrophilic","neutral","acidic","non-polar","neg",11.288,1.678,-0.552,15.5901,-2.984,-0.05,78,85,-1.147,9,9,18,0.173076923076923,"loop",-0.533333333333333,3.87,0.0003593502946672,19.4256842105263,19.4256680571767,19.4169790983636,9.87561363723508,-26,-26,0,0,-26,0,0,0,0,-2,0,-4,-2,0,0,0,0,-6,0,-6,-2,-6,0,-11,-21,0.752466367713005,-0.142635658914729,0.567825377515862,-0.508780903665814,-0.013089005235602,0.821052631578947,-0.944810543657331,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.124,"9:9","147/150","R:G",2.96659528728018,0.0079500503166054,1.11770528264822,2.65418382943607,2.87215213651461,380.0971589756,1.28837632444196,0.0036816889015929,2.43395291165754,1.92061868691892,951.403114304703,0.0016748373055023,"lineage4","dr_mutations_pyrazinamide","ASP",0,"SRR7341652","SRR7341652","lineage4.4.1.1","ro","Romania","pnca_p.gly17asp","A","S","GLY","GA17","pnca_complex.pdb"
|
|
"G17D","L4","PZA","G","G17",17,"D",NA,"MDR","DM","hydrophobic","hydrophilic","neutral","acidic","non-polar","neg",11.288,1.678,-0.552,15.5901,-2.984,-0.05,78,85,-1.147,9,9,18,0.173076923076923,"loop",-0.533333333333333,3.87,0.0003593502946672,19.4256842105263,19.4256680571767,19.4169790983636,9.87561363723508,-26,-26,0,0,-26,0,0,0,0,-2,0,-4,-2,0,0,0,0,-6,0,-6,-2,-6,0,-11,-21,0.752466367713005,-0.142635658914729,0.567825377515862,-0.508780903665814,-0.013089005235602,0.821052631578947,-0.944810543657331,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.124,"9:9","147/150","R:G",2.96659528728018,0.0079500503166054,1.11770528264822,2.65418382943607,2.87215213651461,380.0971589756,1.28837632444196,0.0036816889015929,2.43395291165754,1.92061868691892,951.403114304703,0.0016748373055023,"lineage4","dr_mutations_pyrazinamide","ASP",0,"ERR2179647","ERR2179647","lineage4.5","cn","China","pnca_p.gly17asp","A","S","GLY","GA17","pnca_complex.pdb"
|
|
"G17D","L2","PZA","G","G17",17,"D",1,"MDR","DM","hydrophobic","hydrophilic","neutral","acidic","non-polar","neg",11.288,1.678,-0.552,15.5901,-2.984,-0.05,78,85,-1.147,9,9,18,0.173076923076923,"loop",-0.533333333333333,3.87,0.0003593502946672,19.4256842105263,19.4256680571767,19.4169790983636,9.87561363723508,-26,-26,0,0,-26,0,0,0,0,-2,0,-4,-2,0,0,0,0,-6,0,-6,-2,-6,0,-11,-21,0.752466367713005,-0.142635658914729,0.567825377515862,-0.508780903665814,-0.013089005235602,0.821052631578947,-0.944810543657331,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.124,"9:9","147/150","R:G",2.96659528728018,0.0079500503166054,1.11770528264822,2.65418382943607,2.87215213651461,380.0971589756,1.28837632444196,0.0036816889015929,2.43395291165754,1.92061868691892,951.403114304703,0.0016748373055023,"lineage2","dr_mutations_pyrazinamide","ASP",0,"ERR2199786","ERR2199786","lineage2.2.1","de","Germany","pnca_p.gly17asp","A","S","GLY","GA17","pnca_complex.pdb"
|
|
"G17D","L4","PZA","G","G17",17,"D",NA,"MDR","DM","hydrophobic","hydrophilic","neutral","acidic","non-polar","neg",11.288,1.678,-0.552,15.5901,-2.984,-0.05,78,85,-1.147,9,9,18,0.173076923076923,"loop",-0.533333333333333,3.87,0.0003593502946672,19.4256842105263,19.4256680571767,19.4169790983636,9.87561363723508,-26,-26,0,0,-26,0,0,0,0,-2,0,-4,-2,0,0,0,0,-6,0,-6,-2,-6,0,-11,-21,0.752466367713005,-0.142635658914729,0.567825377515862,-0.508780903665814,-0.013089005235602,0.821052631578947,-0.944810543657331,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.124,"9:9","147/150","R:G",2.96659528728018,0.0079500503166054,1.11770528264822,2.65418382943607,2.87215213651461,380.0971589756,1.28837632444196,0.0036816889015929,2.43395291165754,1.92061868691892,951.403114304703,0.0016748373055023,"lineage4","dr_mutations_pyrazinamide","ASP",0,"ERR1035350","ERR1035350","lineage4.3.2","br","Brazil","pnca_p.gly17asp","A","S","GLY","GA17","pnca_complex.pdb"
|
|
"G17D","L4","PZA","G","G17",17,"D",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","neutral","acidic","non-polar","neg",11.288,1.678,-0.552,15.5901,-2.984,-0.05,78,85,-1.147,9,9,18,0.173076923076923,"loop",-0.533333333333333,3.87,0.0003593502946672,19.4256842105263,19.4256680571767,19.4169790983636,9.87561363723508,-26,-26,0,0,-26,0,0,0,0,-2,0,-4,-2,0,0,0,0,-6,0,-6,-2,-6,0,-11,-21,0.752466367713005,-0.142635658914729,0.567825377515862,-0.508780903665814,-0.013089005235602,0.821052631578947,-0.944810543657331,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.124,"9:9","147/150","R:G",2.96659528728018,0.0079500503166054,1.11770528264822,2.65418382943607,2.87215213651461,380.0971589756,1.28837632444196,0.0036816889015929,2.43395291165754,1.92061868691892,951.403114304703,0.0016748373055023,"lineage4","dr_mutations_pyrazinamide","ASP",0,"ERR1035277","ERR1035277","lineage4.3.2","br","Brazil","pnca_p.gly17asp","A","S","GLY","GA17","pnca_complex.pdb"
|
|
"G17D","L4","PZA","G","G17",17,"D",NA,"MDR","DM","hydrophobic","hydrophilic","neutral","acidic","non-polar","neg",11.288,1.678,-0.552,15.5901,-2.984,-0.05,78,85,-1.147,9,9,18,0.173076923076923,"loop",-0.533333333333333,3.87,0.0003593502946672,19.4256842105263,19.4256680571767,19.4169790983636,9.87561363723508,-26,-26,0,0,-26,0,0,0,0,-2,0,-4,-2,0,0,0,0,-6,0,-6,-2,-6,0,-11,-21,0.752466367713005,-0.142635658914729,0.567825377515862,-0.508780903665814,-0.013089005235602,0.821052631578947,-0.944810543657331,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.124,"9:9","147/150","R:G",2.96659528728018,0.0079500503166054,1.11770528264822,2.65418382943607,2.87215213651461,380.0971589756,1.28837632444196,0.0036816889015929,2.43395291165754,1.92061868691892,951.403114304703,0.0016748373055023,"lineage4","dr_mutations_pyrazinamide","ASP",0,"SRS797397","SRR1723934","lineage4.5","cn","China:Shanghai","pnca_p.gly17asp","A","S","GLY","GA17","pnca_complex.pdb"
|
|
"G17D","L4","PZA","G","G17",17,"D",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","neutral","acidic","non-polar","neg",11.288,1.678,-0.552,15.5901,-2.984,-0.05,78,85,-1.147,9,9,18,0.173076923076923,"loop",-0.533333333333333,3.87,0.0003593502946672,19.4256842105263,19.4256680571767,19.4169790983636,9.87561363723508,-26,-26,0,0,-26,0,0,0,0,-2,0,-4,-2,0,0,0,0,-6,0,-6,-2,-6,0,-11,-21,0.752466367713005,-0.142635658914729,0.567825377515862,-0.508780903665814,-0.013089005235602,0.821052631578947,-0.944810543657331,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.124,"9:9","147/150","R:G",2.96659528728018,0.0079500503166054,1.11770528264822,2.65418382943607,2.87215213651461,380.0971589756,1.28837632444196,0.0036816889015929,2.43395291165754,1.92061868691892,951.403114304703,0.0016748373055023,"lineage4","dr_mutations_pyrazinamide","ASP",0,"SRR7341681","SRR7341681","lineage4.4.1.1","ro","Romania","pnca_p.gly17asp","A","S","GLY","GA17","pnca_complex.pdb"
|
|
"G17D","L4","PZA","G","G17",17,"D",1,"MDR","DM","hydrophobic","hydrophilic","neutral","acidic","non-polar","neg",11.288,1.678,-0.552,15.5901,-2.984,-0.05,78,85,-1.147,9,9,18,0.173076923076923,"loop",-0.533333333333333,3.87,0.0003593502946672,19.4256842105263,19.4256680571767,19.4169790983636,9.87561363723508,-26,-26,0,0,-26,0,0,0,0,-2,0,-4,-2,0,0,0,0,-6,0,-6,-2,-6,0,-11,-21,0.752466367713005,-0.142635658914729,0.567825377515862,-0.508780903665814,-0.013089005235602,0.821052631578947,-0.944810543657331,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.124,"9:9","147/150","R:G",2.96659528728018,0.0079500503166054,1.11770528264822,2.65418382943607,2.87215213651461,380.0971589756,1.28837632444196,0.0036816889015929,2.43395291165754,1.92061868691892,951.403114304703,0.0016748373055023,"lineage4","dr_mutations_pyrazinamide","ASP",0,"MDR_9160","SRR6824591","lineage4.5","cn","China: Yangpu District, Shanghai","pnca_p.gly17asp","A","S","GLY","GA17","pnca_complex.pdb"
|
|
"G17D","L2","PZA","G","G17",17,"D",0,"Pre-XDR","DM","hydrophobic","hydrophilic","neutral","acidic","non-polar","neg",11.288,1.678,-0.552,15.5901,-2.984,-0.05,78,85,-1.147,9,9,18,0.173076923076923,"loop",-0.533333333333333,3.87,0.0003593502946672,19.4256842105263,19.4256680571767,19.4169790983636,9.87561363723508,-26,-26,0,0,-26,0,0,0,0,-2,0,-4,-2,0,0,0,0,-6,0,-6,-2,-6,0,-11,-21,0.752466367713005,-0.142635658914729,0.567825377515862,-0.508780903665814,-0.013089005235602,0.821052631578947,-0.944810543657331,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.124,"9:9","147/150","R:G",2.96659528728018,0.0079500503166054,1.11770528264822,2.65418382943607,2.87215213651461,380.0971589756,1.28837632444196,0.0036816889015929,2.43395291165754,1.92061868691892,951.403114304703,0.0016748373055023,"lineage2","dr_mutations_pyrazinamide","ASP",0,"ERR2515224","ERR2515224","lineage2.2.1","za","South Africa","pnca_p.gly17asp","A","S","GLY","GA17","pnca_complex.pdb"
|
|
"G17D","L4","PZA","G","G17",17,"D",1,"MDR","DM","hydrophobic","hydrophilic","neutral","acidic","non-polar","neg",11.288,1.678,-0.552,15.5901,-2.984,-0.05,78,85,-1.147,9,9,18,0.173076923076923,"loop",-0.533333333333333,3.87,0.0003593502946672,19.4256842105263,19.4256680571767,19.4169790983636,9.87561363723508,-26,-26,0,0,-26,0,0,0,0,-2,0,-4,-2,0,0,0,0,-6,0,-6,-2,-6,0,-11,-21,0.752466367713005,-0.142635658914729,0.567825377515862,-0.508780903665814,-0.013089005235602,0.821052631578947,-0.944810543657331,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.124,"9:9","147/150","R:G",2.96659528728018,0.0079500503166054,1.11770528264822,2.65418382943607,2.87215213651461,380.0971589756,1.28837632444196,0.0036816889015929,2.43395291165754,1.92061868691892,951.403114304703,0.0016748373055023,"lineage4","dr_mutations_pyrazinamide","ASP",0,"ERR2864227","ERR2864227","lineage4.3.2","pt","Portugal","pnca_p.gly17asp","A","S","GLY","GA17","pnca_complex.pdb"
|
|
"G17R","L2","PZA","G","G17",17,"R",1,"MDR","OM","hydrophobic","hydrophilic","neutral","basic","non-polar","pos",11.288,0.099,-0.0579999999999999,13.8675,-2.189,0.01,86,91,-1.147,9,9,18,0.173076923076923,"loop",-0.533333333333333,3.87,7.18700589334483e-05,9.70142977291842,188179.926264663,Inf,0.763784339928386,-74,-16,0,0,-16,0,0,0,0,-2,0,-2,-2,0,0,0,0,-7,0,-7,-5,-10,0,-13,-21,0.0443946188340807,-0.0149870801033591,0.505084535872202,-0.373231031543052,0.0056179775280898,0.905263157894737,-0.944810543657331,"Stabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-1.221,-1.124,"9:9","147/150","R:G",12.1451538387266,0.919026337424239,119.468044436241,0.10166027154825,5.0115366606189e-06,NA,0.986835744238421,0.170978870202674,0.767057556984365,0.124324963210678,Inf,0.382146811758261,"lineage2","other_mutations_pyrazinamide","ARG",0,"ERR2510655","ERR2510655","lineage2.2.1","it","Italy","pnca_p.gly17arg","A","S","GLY","GA17","pnca_complex.pdb"
|
|
"G17S","L4","PZA","G","G17",17,"S",0,"Pre-MDR","OM","hydrophobic","hydrophilic","neutral","neutral","non-polar","polar",11.288,0.598,-0.437,8.97262,-1.946,-0.26,68,80,-1.147,9,9,18,0.173076923076923,"loop",-0.533333333333333,3.87,0.0002156101768003,2.42493692178301,2.4249395742581,2.42473736947533,4.31445715363782e-25,-6,0,0,0,0,0,0,0,0,-2,0,-2,-2,0,0,0,0,-7,0,-7,0,-4,0,-11,-19,0.268161434977578,-0.112919896640827,0.32680235141573,-0.331798806479113,-0.0680628272251308,0.715789473684211,-0.944810543657331,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.124,"9:9","147/150","R:G",0.885806606247281,0.469406216824826,1.22442753211922,0.723445514749362,0.112662937620391,25.327054747117,0.384700446081433,0.430258985168156,0.366270051463612,0.0410854444106247,46.5881472867033,0.999999999999476,"lineage4","other_mutations_pyrazinamide","SER",0,"1054X-sc-2012-02-09T18:57:40Z-1355318,ERR133985","ERR133985","lineage4.3.3","ru","Russia","pnca_p.gly17ser","A","S","GLY","GA17","pnca_complex.pdb"
|
|
"G17S","L2","PZA","G","G17",17,"S",NA,"MDR","OM","hydrophobic","hydrophilic","neutral","neutral","non-polar","polar",11.288,0.598,-0.437,8.97262,-1.946,-0.26,68,80,-1.147,9,9,18,0.173076923076923,"loop",-0.533333333333333,3.87,0.0002156101768003,2.42493692178301,2.4249395742581,2.42473736947533,4.31445715363782e-25,-6,0,0,0,0,0,0,0,0,-2,0,-2,-2,0,0,0,0,-7,0,-7,0,-4,0,-11,-19,0.268161434977578,-0.112919896640827,0.32680235141573,-0.331798806479113,-0.0680628272251308,0.715789473684211,-0.944810543657331,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.124,"9:9","147/150","R:G",0.885806606247281,0.469406216824826,1.22442753211922,0.723445514749362,0.112662937620391,25.327054747117,0.384700446081433,0.430258985168156,0.366270051463612,0.0410854444106247,46.5881472867033,0.999999999999476,"lineage2","other_mutations_pyrazinamide","SER",0,"ERR718504","ERR718504","lineage2.2.1","th","Thailand","pnca_p.gly17ser","A","S","GLY","GA17","pnca_complex.pdb"
|
|
"G17S","L4","PZA","G","G17",17,"S",NA,"XDR","OM","hydrophobic","hydrophilic","neutral","neutral","non-polar","polar",11.288,0.598,-0.437,8.97262,-1.946,-0.26,68,80,-1.147,9,9,18,0.173076923076923,"loop",-0.533333333333333,3.87,0.0002156101768003,2.42493692178301,2.4249395742581,2.42473736947533,4.31445715363782e-25,-6,0,0,0,0,0,0,0,0,-2,0,-2,-2,0,0,0,0,-7,0,-7,0,-4,0,-11,-19,0.268161434977578,-0.112919896640827,0.32680235141573,-0.331798806479113,-0.0680628272251308,0.715789473684211,-0.944810543657331,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.124,"9:9","147/150","R:G",0.885806606247281,0.469406216824826,1.22442753211922,0.723445514749362,0.112662937620391,25.327054747117,0.384700446081433,0.430258985168156,0.366270051463612,0.0410854444106247,46.5881472867033,0.999999999999476,"lineage4","other_mutations_pyrazinamide","SER",0,"SRR7341649","SRR7341649","lineage4.4.1.1","ro","Romania","pnca_p.gly17ser","A","S","GLY","GA17","pnca_complex.pdb"
|
|
"G17S","L2","PZA","G","G17",17,"S",NA,"MDR","OM","hydrophobic","hydrophilic","neutral","neutral","non-polar","polar",11.288,0.598,-0.437,8.97262,-1.946,-0.26,68,80,-1.147,9,9,18,0.173076923076923,"loop",-0.533333333333333,3.87,0.0002156101768003,2.42493692178301,2.4249395742581,2.42473736947533,4.31445715363782e-25,-6,0,0,0,0,0,0,0,0,-2,0,-2,-2,0,0,0,0,-7,0,-7,0,-4,0,-11,-19,0.268161434977578,-0.112919896640827,0.32680235141573,-0.331798806479113,-0.0680628272251308,0.715789473684211,-0.944810543657331,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.124,"9:9","147/150","R:G",0.885806606247281,0.469406216824826,1.22442753211922,0.723445514749362,0.112662937620391,25.327054747117,0.384700446081433,0.430258985168156,0.366270051463612,0.0410854444106247,46.5881472867033,0.999999999999476,"lineage2","other_mutations_pyrazinamide","SER",0,"SRS797310","SRR1723840","lineage2.2.1","cn","China:InnerMongolia","pnca_p.gly17ser","A","S","GLY","GA17","pnca_complex.pdb"
|
|
"G17S","L3","PZA","G","G17",17,"S",NA,"Pre-XDR","OM","hydrophobic","hydrophilic","neutral","neutral","non-polar","polar",11.288,0.598,-0.437,8.97262,-1.946,-0.26,68,80,-1.147,9,9,18,0.173076923076923,"loop",-0.533333333333333,3.87,0.0002156101768003,2.42493692178301,2.4249395742581,2.42473736947533,4.31445715363782e-25,-6,0,0,0,0,0,0,0,0,-2,0,-2,-2,0,0,0,0,-7,0,-7,0,-4,0,-11,-19,0.268161434977578,-0.112919896640827,0.32680235141573,-0.331798806479113,-0.0680628272251308,0.715789473684211,-0.944810543657331,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.124,"9:9","147/150","R:G",0.885806606247281,0.469406216824826,1.22442753211922,0.723445514749362,0.112662937620391,25.327054747117,0.384700446081433,0.430258985168156,0.366270051463612,0.0410854444106247,46.5881472867033,0.999999999999476,"lineage3","other_mutations_pyrazinamide","SER",0,"ERR3335740","ERR3335740","lineage3","pk","Pakistan","pnca_p.gly17ser","A","S","GLY","GA17","pnca_complex.pdb"
|
|
"G17S","L4","PZA","G","G17",17,"S",0,"MDR","OM","hydrophobic","hydrophilic","neutral","neutral","non-polar","polar",11.288,0.598,-0.437,8.97262,-1.946,-0.26,68,80,-1.147,9,9,18,0.173076923076923,"loop",-0.533333333333333,3.87,0.0002156101768003,2.42493692178301,2.4249395742581,2.42473736947533,4.31445715363782e-25,-6,0,0,0,0,0,0,0,0,-2,0,-2,-2,0,0,0,0,-7,0,-7,0,-4,0,-11,-19,0.268161434977578,-0.112919896640827,0.32680235141573,-0.331798806479113,-0.0680628272251308,0.715789473684211,-0.944810543657331,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.124,"9:9","147/150","R:G",0.885806606247281,0.469406216824826,1.22442753211922,0.723445514749362,0.112662937620391,25.327054747117,0.384700446081433,0.430258985168156,0.366270051463612,0.0410854444106247,46.5881472867033,0.999999999999476,"lineage4","other_mutations_pyrazinamide","SER",0,"SAMN03647129","SRR2099956","lineage4.3.3","","","pnca_p.gly17ser","A","S","GLY","GA17","pnca_complex.pdb"
|
|
"G17S","L2","PZA","G","G17",17,"S",1,"Pre-MDR","OM","hydrophobic","hydrophilic","neutral","neutral","non-polar","polar",11.288,0.598,-0.437,8.97262,-1.946,-0.26,68,80,-1.147,9,9,18,0.173076923076923,"loop",-0.533333333333333,3.87,0.0002156101768003,2.42493692178301,2.4249395742581,2.42473736947533,4.31445715363782e-25,-6,0,0,0,0,0,0,0,0,-2,0,-2,-2,0,0,0,0,-7,0,-7,0,-4,0,-11,-19,0.268161434977578,-0.112919896640827,0.32680235141573,-0.331798806479113,-0.0680628272251308,0.715789473684211,-0.944810543657331,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.124,"9:9","147/150","R:G",0.885806606247281,0.469406216824826,1.22442753211922,0.723445514749362,0.112662937620391,25.327054747117,0.384700446081433,0.430258985168156,0.366270051463612,0.0410854444106247,46.5881472867033,0.999999999999476,"lineage2","other_mutations_pyrazinamide","SER",0,"MDR_5106","SRR6824654","lineage2.2.1","cn","China: Huimin District, Huhhot City, Inner Mongolia Province","pnca_p.gly17ser","A","S","GLY","GA17","pnca_complex.pdb"
|
|
"S18P","L1","PZA","S","S18",18,"P",0,"Other","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",9.173,-1.13,-0.521,1.09268,0.064,-0.16,53,75,-0.553,7,7,53,0.341935483870968,"loop",0.866666666666667,3.72,7.18700589334483e-05,2.42412778478352,0.0001249735077034,0,1.03410070803344e-29,0,0,0,0,0,0,0,0,0,4,0,4,0,0,0,0,0,-4,2,-6,-2,-2,0,-8,0,-0.286220871327254,-0.134625322997416,0.0397977840747674,0.0540540540540541,-0.0418848167539267,0.557894736842105,-0.455518945634267,"Destabilising","Destabilising","Destabilising","Stabilising","Destabilising","effect",-0.674,-0.485,"7:7","147/150","T:S:A:R:K:N:H:E",-8.9874087814964,0.940032862253632,119.468044435489,-0.0752285585987761,NA,4692673.51081157,0.384555509373631,1,0,0,188.544222231268,0.999999999999997,"lineage1","dr_mutations_pyrazinamide","PRO",0,"SAMN03648394,SRR2101147","SRR2101147","lineage1.2.2","","","pnca_p.ser18pro","A","T","SER","SA18","pnca_complex.pdb"
|
|
"L19P","L4","PZA","L","L19",19,"P",1,"MDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",5.113,-1.723,-1.791,2.98164,-1.477,-1.37,83,91,-1.173,9,9,27,0.134328358208955,"loop",1.6,4.47,0.0003593502946672,19.4256842105263,19.4256680571767,19.4169790983636,9.87561363723508,26,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,7,6,-1,1,-4,0,-2,0,-0.436423505572442,-0.462790697674418,0.108597819040057,-0.251832907075874,-0.358638743455497,0.873684210526316,-0.966227347611203,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","147/150","L:V",2.96659528728018,0.0079500503166053,1.11770528264822,2.65418382943607,2.87215213651493,380.09715897553,1.28837632444196,0.0036816889015929,2.43395291165754,1.92061868691892,951.403114304703,0.0016748373055023,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR2041727","ERR2041727","lineage4.4.1.1","rs","Serbia","pnca_p.leu19pro","A","T","LEU","LA19","pnca_complex.pdb"
|
|
"L19P","L4","PZA","L","L19",19,"P",NA,"MDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",5.113,-1.723,-1.791,2.98164,-1.477,-1.37,83,91,-1.173,9,9,27,0.134328358208955,"loop",1.6,4.47,0.0003593502946672,19.4256842105263,19.4256680571767,19.4169790983636,9.87561363723508,26,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,7,6,-1,1,-4,0,-2,0,-0.436423505572442,-0.462790697674418,0.108597819040057,-0.251832907075874,-0.358638743455497,0.873684210526316,-0.966227347611203,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","147/150","L:V",2.96659528728018,0.0079500503166053,1.11770528264822,2.65418382943607,2.87215213651493,380.09715897553,1.28837632444196,0.0036816889015929,2.43395291165754,1.92061868691892,951.403114304703,0.0016748373055023,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR1555040","ERR1555040","lineage4.8","","","pnca_p.leu19pro","A","T","LEU","LA19","pnca_complex.pdb"
|
|
"L19P","L2","PZA","L","L19",19,"P",NA,"MDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",5.113,-1.723,-1.791,2.98164,-1.477,-1.37,83,91,-1.173,9,9,27,0.134328358208955,"loop",1.6,4.47,0.0003593502946672,19.4256842105263,19.4256680571767,19.4169790983636,9.87561363723508,26,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,7,6,-1,1,-4,0,-2,0,-0.436423505572442,-0.462790697674418,0.108597819040057,-0.251832907075874,-0.358638743455497,0.873684210526316,-0.966227347611203,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","147/150","L:V",2.96659528728018,0.0079500503166053,1.11770528264822,2.65418382943607,2.87215213651493,380.09715897553,1.28837632444196,0.0036816889015929,2.43395291165754,1.92061868691892,951.403114304703,0.0016748373055023,"lineage2","dr_mutations_pyrazinamide","PRO",0,"SRR5709824,SAMN07236331","SRR5709824","lineage2.1","th","Thailand","pnca_p.leu19pro","A","T","LEU","LA19","pnca_complex.pdb"
|
|
"L19P","L4","PZA","L","L19",19,"P",1,"Pre-XDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",5.113,-1.723,-1.791,2.98164,-1.477,-1.37,83,91,-1.173,9,9,27,0.134328358208955,"loop",1.6,4.47,0.0003593502946672,19.4256842105263,19.4256680571767,19.4169790983636,9.87561363723508,26,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,7,6,-1,1,-4,0,-2,0,-0.436423505572442,-0.462790697674418,0.108597819040057,-0.251832907075874,-0.358638743455497,0.873684210526316,-0.966227347611203,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","147/150","L:V",2.96659528728018,0.0079500503166053,1.11770528264822,2.65418382943607,2.87215213651493,380.09715897553,1.28837632444196,0.0036816889015929,2.43395291165754,1.92061868691892,951.403114304703,0.0016748373055023,"lineage4","dr_mutations_pyrazinamide","PRO",0,"SAMN10961312","SRR8651555","lineage4.4.2","cn","China:Wenzhou","pnca_p.leu19pro","A","T","LEU","LA19","pnca_complex.pdb"
|
|
"L19P","L2","PZA","L","L19",19,"P",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",5.113,-1.723,-1.791,2.98164,-1.477,-1.37,83,91,-1.173,9,9,27,0.134328358208955,"loop",1.6,4.47,0.0003593502946672,19.4256842105263,19.4256680571767,19.4169790983636,9.87561363723508,26,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,7,6,-1,1,-4,0,-2,0,-0.436423505572442,-0.462790697674418,0.108597819040057,-0.251832907075874,-0.358638743455497,0.873684210526316,-0.966227347611203,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","147/150","L:V",2.96659528728018,0.0079500503166053,1.11770528264822,2.65418382943607,2.87215213651493,380.09715897553,1.28837632444196,0.0036816889015929,2.43395291165754,1.92061868691892,951.403114304703,0.0016748373055023,"lineage2","dr_mutations_pyrazinamide","PRO",0,"SAMN02419676","SRR1169088_SRR1162980_SRR1163326_SRR1172264","lineage2.2.1","by","Belarus","pnca_p.leu19pro","A","T","LEU","LA19","pnca_complex.pdb"
|
|
"L19P","L2","PZA","L","L19",19,"P",1,"Pre-XDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",5.113,-1.723,-1.791,2.98164,-1.477,-1.37,83,91,-1.173,9,9,27,0.134328358208955,"loop",1.6,4.47,0.0003593502946672,19.4256842105263,19.4256680571767,19.4169790983636,9.87561363723508,26,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,7,6,-1,1,-4,0,-2,0,-0.436423505572442,-0.462790697674418,0.108597819040057,-0.251832907075874,-0.358638743455497,0.873684210526316,-0.966227347611203,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","147/150","L:V",2.96659528728018,0.0079500503166053,1.11770528264822,2.65418382943607,2.87215213651493,380.09715897553,1.28837632444196,0.0036816889015929,2.43395291165754,1.92061868691892,951.403114304703,0.0016748373055023,"lineage2","dr_mutations_pyrazinamide","PRO",0,"ERR2510667","ERR2510667","lineage2.2.1","it","Italy","pnca_p.leu19pro","A","T","LEU","LA19","pnca_complex.pdb"
|
|
"L19P","L4","PZA","L","L19",19,"P",NA,"MDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",5.113,-1.723,-1.791,2.98164,-1.477,-1.37,83,91,-1.173,9,9,27,0.134328358208955,"loop",1.6,4.47,0.0003593502946672,19.4256842105263,19.4256680571767,19.4169790983636,9.87561363723508,26,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,7,6,-1,1,-4,0,-2,0,-0.436423505572442,-0.462790697674418,0.108597819040057,-0.251832907075874,-0.358638743455497,0.873684210526316,-0.966227347611203,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","147/150","L:V",2.96659528728018,0.0079500503166053,1.11770528264822,2.65418382943607,2.87215213651493,380.09715897553,1.28837632444196,0.0036816889015929,2.43395291165754,1.92061868691892,951.403114304703,0.0016748373055023,"lineage4","dr_mutations_pyrazinamide","PRO",0,"SAMN07659117","SRR6044999","lineage4.1.2.1","gb","UK","pnca_p.leu19pro","A","T","LEU","LA19","pnca_complex.pdb"
|
|
"L19P","L2","PZA","L","L19",19,"P",1,"Pre-XDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",5.113,-1.723,-1.791,2.98164,-1.477,-1.37,83,91,-1.173,9,9,27,0.134328358208955,"loop",1.6,4.47,0.0003593502946672,19.4256842105263,19.4256680571767,19.4169790983636,9.87561363723508,26,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,7,6,-1,1,-4,0,-2,0,-0.436423505572442,-0.462790697674418,0.108597819040057,-0.251832907075874,-0.358638743455497,0.873684210526316,-0.966227347611203,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","147/150","L:V",2.96659528728018,0.0079500503166053,1.11770528264822,2.65418382943607,2.87215213651493,380.09715897553,1.28837632444196,0.0036816889015929,2.43395291165754,1.92061868691892,951.403114304703,0.0016748373055023,"lineage2","dr_mutations_pyrazinamide","PRO",0,"ERR2510673","ERR2510673","lineage2.2.1","it","Italy","pnca_p.leu19pro","A","T","LEU","LA19","pnca_complex.pdb"
|
|
"L19P","L2","PZA","L","L19",19,"P",0,"MDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",5.113,-1.723,-1.791,2.98164,-1.477,-1.37,83,91,-1.173,9,9,27,0.134328358208955,"loop",1.6,4.47,0.0003593502946672,19.4256842105263,19.4256680571767,19.4169790983636,9.87561363723508,26,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,7,6,-1,1,-4,0,-2,0,-0.436423505572442,-0.462790697674418,0.108597819040057,-0.251832907075874,-0.358638743455497,0.873684210526316,-0.966227347611203,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","147/150","L:V",2.96659528728018,0.0079500503166053,1.11770528264822,2.65418382943607,2.87215213651493,380.09715897553,1.28837632444196,0.0036816889015929,2.43395291165754,1.92061868691892,951.403114304703,0.0016748373055023,"lineage2","dr_mutations_pyrazinamide","PRO",0,"ERR553058","ERR553058","lineage2.2.1","sz","Swaziland","pnca_p.leu19pro","A","T","LEU","LA19","pnca_complex.pdb"
|
|
"L19R","L3","PZA","L","L19",19,"R",1,"Pre-XDR","DM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",5.113,-0.665,-1.418,2.62574,-1.398,-0.57,81,91,-1.173,9,9,27,0.134328358208955,"loop",1.6,4.47,0.0002156101768003,9.70466975178797,9.70465898653051,9.70194990589383,2.29168245016684,-54,-30,0,0,-30,0,0,0,0,0,0,0,0,0,0,0,0,2,0,-1,2,-4,0,0,-8,-0.168439716312057,-0.36640826873385,0.0956351663400812,-0.238363171355499,-0.149214659685864,0.852631578947368,-0.966227347611203,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","147/150","L:V",2.27260607808817,0.0634455902260897,1.22442760158496,1.8560559033024,0.929172866364976,208.881603004981,0.986980761010679,0.0776844925942494,1.10966566656461,0.504888890842109,570.372842410328,0.130068862702538,"lineage3","dr_mutations_pyrazinamide","ARG",0,"ERR3335797","ERR3335797","lineage3","pk","Pakistan","pnca_p.leu19arg","A","T","LEU","LA19","pnca_complex.pdb"
|
|
"L19R","L4","PZA","L","L19",19,"R",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",5.113,-0.665,-1.418,2.62574,-1.398,-0.57,81,91,-1.173,9,9,27,0.134328358208955,"loop",1.6,4.47,0.0002156101768003,9.70466975178797,9.70465898653051,9.70194990589383,2.29168245016684,-54,-30,0,0,-30,0,0,0,0,0,0,0,0,0,0,0,0,2,0,-1,2,-4,0,0,-8,-0.168439716312057,-0.36640826873385,0.0956351663400812,-0.238363171355499,-0.149214659685864,0.852631578947368,-0.966227347611203,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","147/150","L:V",2.27260607808817,0.0634455902260897,1.22442760158496,1.8560559033024,0.929172866364976,208.881603004981,0.986980761010679,0.0776844925942494,1.10966566656461,0.504888890842109,570.372842410328,0.130068862702538,"lineage4","dr_mutations_pyrazinamide","ARG",0,"2721","ERR2433009","lineage4.3.4.2.1","br","Momazbique","pnca_p.leu19arg","A","T","LEU","LA19","pnca_complex.pdb"
|
|
"L19R","L3","PZA","L","L19",19,"R",0,"Pre-XDR","DM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",5.113,-0.665,-1.418,2.62574,-1.398,-0.57,81,91,-1.173,9,9,27,0.134328358208955,"loop",1.6,4.47,0.0002156101768003,9.70466975178797,9.70465898653051,9.70194990589383,2.29168245016684,-54,-30,0,0,-30,0,0,0,0,0,0,0,0,0,0,0,0,2,0,-1,2,-4,0,0,-8,-0.168439716312057,-0.36640826873385,0.0956351663400812,-0.238363171355499,-0.149214659685864,0.852631578947368,-0.966227347611203,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","147/150","L:V",2.27260607808817,0.0634455902260897,1.22442760158496,1.8560559033024,0.929172866364976,208.881603004981,0.986980761010679,0.0776844925942494,1.10966566656461,0.504888890842109,570.372842410328,0.130068862702538,"lineage3","dr_mutations_pyrazinamide","ARG",0,"ERR3335752","ERR3335752","lineage3","pk","Pakistan","pnca_p.leu19arg","A","T","LEU","LA19","pnca_complex.pdb"
|
|
"L19R","L4","PZA","L","L19",19,"R",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",5.113,-0.665,-1.418,2.62574,-1.398,-0.57,81,91,-1.173,9,9,27,0.134328358208955,"loop",1.6,4.47,0.0002156101768003,9.70466975178797,9.70465898653051,9.70194990589383,2.29168245016684,-54,-30,0,0,-30,0,0,0,0,0,0,0,0,0,0,0,0,2,0,-1,2,-4,0,0,-8,-0.168439716312057,-0.36640826873385,0.0956351663400812,-0.238363171355499,-0.149214659685864,0.852631578947368,-0.966227347611203,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","147/150","L:V",2.27260607808817,0.0634455902260897,1.22442760158496,1.8560559033024,0.929172866364976,208.881603004981,0.986980761010679,0.0776844925942494,1.10966566656461,0.504888890842109,570.372842410328,0.130068862702538,"lineage4","dr_mutations_pyrazinamide","ARG",0,"3185","ERR2433013","lineage4.3.4.2.1","br","Momazbique","pnca_p.leu19arg","A","T","LEU","LA19","pnca_complex.pdb"
|
|
"L19R","L2","PZA","L","L19",19,"R",1,"Pre-XDR","DM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",5.113,-0.665,-1.418,2.62574,-1.398,-0.57,81,91,-1.173,9,9,27,0.134328358208955,"loop",1.6,4.47,0.0002156101768003,9.70466975178797,9.70465898653051,9.70194990589383,2.29168245016684,-54,-30,0,0,-30,0,0,0,0,0,0,0,0,0,0,0,0,2,0,-1,2,-4,0,0,-8,-0.168439716312057,-0.36640826873385,0.0956351663400812,-0.238363171355499,-0.149214659685864,0.852631578947368,-0.966227347611203,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","147/150","L:V",2.27260607808817,0.0634455902260897,1.22442760158496,1.8560559033024,0.929172866364976,208.881603004981,0.986980761010679,0.0776844925942494,1.10966566656461,0.504888890842109,570.372842410328,0.130068862702538,"lineage2","dr_mutations_pyrazinamide","ARG",0,"SAMN10961388","SRR8651579","lineage2.2.1","cn","China:Wenzhou","pnca_p.leu19arg","A","T","LEU","LA19","pnca_complex.pdb"
|
|
"L19V","L4","PZA","L","L19",19,"V",NA,"Pre-MDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",5.113,-1.722,-2.048,1.25265,-1.307,-2.23,7,53,-1.173,9,9,27,0.134328358208955,"loop",1.6,4.47,7.18700589334483e-05,2.42412778478352,0.0001249735077034,0,1.03410070803344e-29,26,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-2,0,-2,-1,-2,0,0,-2,-0.436170212765957,-0.529198966408269,0.0456242396870607,-0.222847399829497,-0.583769633507853,0.0736842105263158,-0.966227347611203,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","147/150","L:V",-8.98740878149641,0.940032862253633,119.46804443549,-0.0752285585987759,NA,4692673.51081035,0.384555509373631,1,0,0,188.544222231268,0.999999999999997,"lineage4","other_mutations_pyrazinamide","VAL",0,"SRR6325448","SRR6325448","lineage4.3","us","","pnca_p.leu19val","A","T","LEU","LA19","pnca_complex.pdb"
|
|
"L19V","L3;L4","PZA","L","L19",19,"V",NA,"Pre-MDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",5.113,-1.722,-2.048,1.25265,-1.307,-2.23,7,53,-1.173,9,9,27,0.134328358208955,"loop",1.6,4.47,7.18700589334483e-05,2.42412778478352,0.0001249735077034,0,1.03410070803344e-29,26,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-2,0,-2,-1,-2,0,0,-2,-0.436170212765957,-0.529198966408269,0.0456242396870607,-0.222847399829497,-0.583769633507853,0.0736842105263158,-0.966227347611203,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","147/150","L:V",-8.98740878149641,0.940032862253633,119.46804443549,-0.0752285585987759,NA,4692673.51081035,0.384555509373631,1,0,0,188.544222231268,0.999999999999997,"lineage3;lineage4","other_mutations_pyrazinamide","VAL",0,"SRR6325444","SRR6325444","lineage4.3;lineage3","us","","pnca_p.leu19val","A","T","LEU","LA19","pnca_complex.pdb"
|
|
"L19V","","PZA","L","L19",19,"V",0,"Pre-MDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",5.113,-1.722,-2.048,1.25265,-1.307,-2.23,7,53,-1.173,9,9,27,0.134328358208955,"loop",1.6,4.47,7.18700589334483e-05,2.42412778478352,0.0001249735077034,0,1.03410070803344e-29,26,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-2,0,-2,-1,-2,0,0,-2,-0.436170212765957,-0.529198966408269,0.0456242396870607,-0.222847399829497,-0.583769633507853,0.0736842105263158,-0.966227347611203,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","147/150","L:V",-8.98740878149641,0.940032862253633,119.46804443549,-0.0752285585987759,NA,4692673.51081035,0.384555509373631,1,0,0,188.544222231268,0.999999999999997,"","other_mutations_pyrazinamide","VAL",0,"ERR1035239","ERR1035239","","pt","Portugal","pnca_p.leu19val","A","T","LEU","LA19","pnca_complex.pdb"
|
|
"L19V","L4","PZA","L","L19",19,"V",NA,"Pre-MDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",5.113,-1.722,-2.048,1.25265,-1.307,-2.23,7,53,-1.173,9,9,27,0.134328358208955,"loop",1.6,4.47,7.18700589334483e-05,2.42412778478352,0.0001249735077034,0,1.03410070803344e-29,26,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-2,0,-2,-1,-2,0,0,-2,-0.436170212765957,-0.529198966408269,0.0456242396870607,-0.222847399829497,-0.583769633507853,0.0736842105263158,-0.966227347611203,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","147/150","L:V",-8.98740878149641,0.940032862253633,119.46804443549,-0.0752285585987759,NA,4692673.51081035,0.384555509373631,1,0,0,188.544222231268,0.999999999999997,"lineage4","other_mutations_pyrazinamide","VAL",0,"SRR6325445","SRR6325445","lineage4.3","us","","pnca_p.leu19val","A","T","LEU","LA19","pnca_complex.pdb"
|
|
"A20P","L3;L4","PZA","A","A20",20,"P",NA,"Pre-MDR","OM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",9.104,-0.318,-0.313,-1.37798,-0.07,0.06,-76,87,-0.39,6,6,52,0.403100775193798,"loop",3.26666666666667,3.81,NA,NA,NA,NA,NA,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-4,2,-6,0,0,0,0,-3,-0.080547112462006,-0.0808785529715762,-0.264935014996539,-0.0119352088661552,0.0337078651685393,-0.817204301075269,-0.321252059308072,"Destabilising","Destabilising","Stabilising","Destabilising","Stabilising","neutral",-0.553,-0.332,"7:6","147/150","P:A:S:Y:E:G:H",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage3;lineage4","other_mutations_pyrazinamide","PRO",0,"SRR6325444","SRR6325444","lineage4.3;lineage3","us","","pnca_p.ala20pro","A","-","ALA","AA20","pnca_complex.pdb"
|
|
"A20P","L6","PZA","A","A20",20,"P",NA,"Sensitive","OM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",9.104,-0.318,-0.313,-1.37798,-0.07,0.06,-76,87,-0.39,6,6,52,0.403100775193798,"loop",3.26666666666667,3.81,NA,NA,NA,NA,NA,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-4,2,-6,0,0,0,0,-3,-0.080547112462006,-0.0808785529715762,-0.264935014996539,-0.0119352088661552,0.0337078651685393,-0.817204301075269,-0.321252059308072,"Destabilising","Destabilising","Stabilising","Destabilising","Stabilising","neutral",-0.553,-0.332,"7:6","147/150","P:A:S:Y:E:G:H",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage6","other_mutations_pyrazinamide","PRO",0,"ERR779852","ERR779852","lineage6","","","pnca_p.ala20pro","A","-","ALA","AA20","pnca_complex.pdb"
|
|
"A20P","L4","PZA","A","A20",20,"P",NA,"Pre-MDR","OM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",9.104,-0.318,-0.313,-1.37798,-0.07,0.06,-76,87,-0.39,6,6,52,0.403100775193798,"loop",3.26666666666667,3.81,NA,NA,NA,NA,NA,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-4,2,-6,0,0,0,0,-3,-0.080547112462006,-0.0808785529715762,-0.264935014996539,-0.0119352088661552,0.0337078651685393,-0.817204301075269,-0.321252059308072,"Destabilising","Destabilising","Stabilising","Destabilising","Stabilising","neutral",-0.553,-0.332,"7:6","147/150","P:A:S:Y:E:G:H",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage4","other_mutations_pyrazinamide","PRO",0,"SRR6325445","SRR6325445","lineage4.3","us","","pnca_p.ala20pro","A","-","ALA","AA20","pnca_complex.pdb"
|
|
"A20P","L4","PZA","A","A20",20,"P",NA,"Pre-MDR","OM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",9.104,-0.318,-0.313,-1.37798,-0.07,0.06,-76,87,-0.39,6,6,52,0.403100775193798,"loop",3.26666666666667,3.81,NA,NA,NA,NA,NA,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-4,2,-6,0,0,0,0,-3,-0.080547112462006,-0.0808785529715762,-0.264935014996539,-0.0119352088661552,0.0337078651685393,-0.817204301075269,-0.321252059308072,"Destabilising","Destabilising","Stabilising","Destabilising","Stabilising","neutral",-0.553,-0.332,"7:6","147/150","P:A:S:Y:E:G:H",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage4","other_mutations_pyrazinamide","PRO",0,"SRR6325448","SRR6325448","lineage4.3","us","","pnca_p.ala20pro","A","-","ALA","AA20","pnca_complex.pdb"
|
|
"A20S","L2","PZA","A","A20",20,"S",NA,"Other","OM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",9.104,0.467,-0.846,-0.127919,-0.376,-0.16,-46,72,-0.39,6,6,52,0.403100775193798,"loop",3.26666666666667,3.81,NA,NA,NA,NA,NA,0,0,0,0,0,0,0,0,0,-4,0,-4,0,0,0,0,0,-3,0,-3,0,0,0,0,-1,0.209417040358744,-0.218604651162791,-0.0245941321233561,-0.0641091219096334,-0.0418848167539267,-0.494623655913978,-0.321252059308072,"Stabilising","Destabilising","Stabilising","Destabilising","Destabilising","neutral",-0.553,-0.332,"7:6","147/150","P:A:S:Y:E:G:H",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage2","other_mutations_pyrazinamide","SER",0,"ERR502943","ERR502943","lineage2.2","","","pnca_p.ala20ser","A","-","ALA","AA20","pnca_complex.pdb"
|
|
"V21A","L4","PZA","V","V21",21,"A",1,"XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",6.521,-0.327,-1.742,1.43401,-1.866,-1.79,60,80,-1.104,9,9,9,0.0517241379310344,"loop",1.76666666666667,4.94,0.0001437401178668,4.85029436501262,4.85029432717736,4.84956447904112,0.0881192621863332,4,0,0,0,0,0,0,0,0,2,0,0,0,0,0,0,0,-1,0,-1,0,2,0,4,1,-0.0828267477203647,-0.450129198966408,0.0522297656597149,-0.318158567774936,-0.468586387434555,0.631578947368421,-0.909390444810544,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.178,-1.062,"9:9","147/150","T:V:C:I",1.57903938912402,0.264247566376722,1.41439286276584,1.11640791656443,0.191756076673664,122.683760399233,0.685768096792206,0.312734154310187,0.504824686014995,0.061763864579114,379.558337204203,0.766581879696361,"lineage4","dr_mutations_pyrazinamide","ALA",0,"SAMN02419617,XTB13-183","SRR1172308_SRR1162962_SRR1168981_SRR1166910","lineage4.3.3","by","Belarus","pnca_p.val21ala","A","-","VAL","VA21","pnca_complex.pdb"
|
|
"V21A","L4","PZA","V","V21",21,"A",NA,"XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",6.521,-0.327,-1.742,1.43401,-1.866,-1.79,60,80,-1.104,9,9,9,0.0517241379310344,"loop",1.76666666666667,4.94,0.0001437401178668,4.85029436501262,4.85029432717736,4.84956447904112,0.0881192621863332,4,0,0,0,0,0,0,0,0,2,0,0,0,0,0,0,0,-1,0,-1,0,2,0,4,1,-0.0828267477203647,-0.450129198966408,0.0522297656597149,-0.318158567774936,-0.468586387434555,0.631578947368421,-0.909390444810544,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.178,-1.062,"9:9","147/150","T:V:C:I",1.57903938912402,0.264247566376722,1.41439286276584,1.11640791656443,0.191756076673664,122.683760399233,0.685768096792206,0.312734154310187,0.504824686014995,0.061763864579114,379.558337204203,0.766581879696361,"lineage4","dr_mutations_pyrazinamide","ALA",0,"SAMN02584661","SRR1169060_SRR1166105","lineage4.2.1","md","Moldova","pnca_p.val21ala","A","-","VAL","VA21","pnca_complex.pdb"
|
|
"V21A","L4","PZA","V","V21",21,"A",NA,"XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",6.521,-0.327,-1.742,1.43401,-1.866,-1.79,60,80,-1.104,9,9,9,0.0517241379310344,"loop",1.76666666666667,4.94,0.0001437401178668,4.85029436501262,4.85029432717736,4.84956447904112,0.0881192621863332,4,0,0,0,0,0,0,0,0,2,0,0,0,0,0,0,0,-1,0,-1,0,2,0,4,1,-0.0828267477203647,-0.450129198966408,0.0522297656597149,-0.318158567774936,-0.468586387434555,0.631578947368421,-0.909390444810544,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.178,-1.062,"9:9","147/150","T:V:C:I",1.57903938912402,0.264247566376722,1.41439286276584,1.11640791656443,0.191756076673664,122.683760399233,0.685768096792206,0.312734154310187,0.504824686014995,0.061763864579114,379.558337204203,0.766581879696361,"lineage4","dr_mutations_pyrazinamide","ALA",0,"SAMN02584650","SRR1169089_SRR1166312","lineage4.2.1","md","Moldova","pnca_p.val21ala","A","-","VAL","VA21","pnca_complex.pdb"
|
|
"V21A","L4","PZA","V","V21",21,"A",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",6.521,-0.327,-1.742,1.43401,-1.866,-1.79,60,80,-1.104,9,9,9,0.0517241379310344,"loop",1.76666666666667,4.94,0.0001437401178668,4.85029436501262,4.85029432717736,4.84956447904112,0.0881192621863332,4,0,0,0,0,0,0,0,0,2,0,0,0,0,0,0,0,-1,0,-1,0,2,0,4,1,-0.0828267477203647,-0.450129198966408,0.0522297656597149,-0.318158567774936,-0.468586387434555,0.631578947368421,-0.909390444810544,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.178,-1.062,"9:9","147/150","T:V:C:I",1.57903938912402,0.264247566376722,1.41439286276584,1.11640791656443,0.191756076673664,122.683760399233,0.685768096792206,0.312734154310187,0.504824686014995,0.061763864579114,379.558337204203,0.766581879696361,"lineage4","dr_mutations_pyrazinamide","ALA",0,"ERR1035285","ERR1035285","lineage4.3.3","br","Brazil","pnca_p.val21ala","A","-","VAL","VA21","pnca_complex.pdb"
|
|
"V21A","L4","PZA","V","V21",21,"A",0,"MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",6.521,-0.327,-1.742,1.43401,-1.866,-1.79,60,80,-1.104,9,9,9,0.0517241379310344,"loop",1.76666666666667,4.94,0.0001437401178668,4.85029436501262,4.85029432717736,4.84956447904112,0.0881192621863332,4,0,0,0,0,0,0,0,0,2,0,0,0,0,0,0,0,-1,0,-1,0,2,0,4,1,-0.0828267477203647,-0.450129198966408,0.0522297656597149,-0.318158567774936,-0.468586387434555,0.631578947368421,-0.909390444810544,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.178,-1.062,"9:9","147/150","T:V:C:I",1.57903938912402,0.264247566376722,1.41439286276584,1.11640791656443,0.191756076673664,122.683760399233,0.685768096792206,0.312734154310187,0.504824686014995,0.061763864579114,379.558337204203,0.766581879696361,"lineage4","dr_mutations_pyrazinamide","ALA",0,"ERR2516286","ERR2516286","lineage4.3.3","be","Belgium","pnca_p.val21ala","A","-","VAL","VA21","pnca_complex.pdb"
|
|
"V21A","L4","PZA","V","V21",21,"A",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",6.521,-0.327,-1.742,1.43401,-1.866,-1.79,60,80,-1.104,9,9,9,0.0517241379310344,"loop",1.76666666666667,4.94,0.0001437401178668,4.85029436501262,4.85029432717736,4.84956447904112,0.0881192621863332,4,0,0,0,0,0,0,0,0,2,0,0,0,0,0,0,0,-1,0,-1,0,2,0,4,1,-0.0828267477203647,-0.450129198966408,0.0522297656597149,-0.318158567774936,-0.468586387434555,0.631578947368421,-0.909390444810544,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.178,-1.062,"9:9","147/150","T:V:C:I",1.57903938912402,0.264247566376722,1.41439286276584,1.11640791656443,0.191756076673664,122.683760399233,0.685768096792206,0.312734154310187,0.504824686014995,0.061763864579114,379.558337204203,0.766581879696361,"lineage4","dr_mutations_pyrazinamide","ALA",0,"SAMN02419660,XTB13-233","SRR1169087_SRR1172443_SRR1163373_SRR1162972","lineage4.3.3","by","Belarus","pnca_p.val21ala","A","-","VAL","VA21","pnca_complex.pdb"
|
|
"V21G","L3","PZA","V","V21",21,"G",1,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",6.521,-0.391,-2.004,2.37287,-2.469,-2.8,70,85,-1.104,9,9,9,0.0517241379310344,"loop",1.76666666666667,4.94,0.0004312203536006,24.2923336141533,24.29233342416,24.2833096922897,14.1977442691074,16,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,2,0,11,15,-0.0990374873353596,-0.517829457364341,0.0864250905091092,-0.420971867007673,-0.732984293193717,0.736842105263158,-0.909390444810544,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.178,-1.062,"9:9","147/150","T:V:C:I",3.19016080361872,0.0035954281300594,1.09565968954933,2.91163472932996,3.91551977432241,465.531063220335,1.38546923679232,0.0007494070007895,3.12528225414311,2.71567844828345,1141.60089496884,0.0001645676755807,"lineage3","dr_mutations_pyrazinamide","GLY",0,"ERR550764,SAMEA2533452","ERR550764","lineage3.1.1","","","pnca_p.val21gly","A","-","VAL","VA21","pnca_complex.pdb"
|
|
"V21G","L4","PZA","V","V21",21,"G",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",6.521,-0.391,-2.004,2.37287,-2.469,-2.8,70,85,-1.104,9,9,9,0.0517241379310344,"loop",1.76666666666667,4.94,0.0004312203536006,24.2923336141533,24.29233342416,24.2833096922897,14.1977442691074,16,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,2,0,11,15,-0.0990374873353596,-0.517829457364341,0.0864250905091092,-0.420971867007673,-0.732984293193717,0.736842105263158,-0.909390444810544,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.178,-1.062,"9:9","147/150","T:V:C:I",3.19016080361872,0.0035954281300594,1.09565968954933,2.91163472932996,3.91551977432241,465.531063220335,1.38546923679232,0.0007494070007895,3.12528225414311,2.71567844828345,1141.60089496884,0.0001645676755807,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR2516713","ERR2516713","lineage4.1.1","pe","Peru","pnca_p.val21gly","A","-","VAL","VA21","pnca_complex.pdb"
|
|
"V21G","L2","PZA","V","V21",21,"G",1,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",6.521,-0.391,-2.004,2.37287,-2.469,-2.8,70,85,-1.104,9,9,9,0.0517241379310344,"loop",1.76666666666667,4.94,0.0004312203536006,24.2923336141533,24.29233342416,24.2833096922897,14.1977442691074,16,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,2,0,11,15,-0.0990374873353596,-0.517829457364341,0.0864250905091092,-0.420971867007673,-0.732984293193717,0.736842105263158,-0.909390444810544,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.178,-1.062,"9:9","147/150","T:V:C:I",3.19016080361872,0.0035954281300594,1.09565968954933,2.91163472932996,3.91551977432241,465.531063220335,1.38546923679232,0.0007494070007895,3.12528225414311,2.71567844828345,1141.60089496884,0.0001645676755807,"lineage2","dr_mutations_pyrazinamide","GLY",0,"ERS2592773","ERR2677426","lineage2.2.1","de","Germany","pnca_p.val21gly","A","-","VAL","VA21","pnca_complex.pdb"
|
|
"V21G","L1","PZA","V","V21",21,"G",0,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",6.521,-0.391,-2.004,2.37287,-2.469,-2.8,70,85,-1.104,9,9,9,0.0517241379310344,"loop",1.76666666666667,4.94,0.0004312203536006,24.2923336141533,24.29233342416,24.2833096922897,14.1977442691074,16,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,2,0,11,15,-0.0990374873353596,-0.517829457364341,0.0864250905091092,-0.420971867007673,-0.732984293193717,0.736842105263158,-0.909390444810544,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.178,-1.062,"9:9","147/150","T:V:C:I",3.19016080361872,0.0035954281300594,1.09565968954933,2.91163472932996,3.91551977432241,465.531063220335,1.38546923679232,0.0007494070007895,3.12528225414311,2.71567844828345,1141.60089496884,0.0001645676755807,"lineage1","dr_mutations_pyrazinamide","GLY",0,"SRR2100301,SAMN03647474","SRR2100301","lineage1.2.2","","","pnca_p.val21gly","A","-","VAL","VA21","pnca_complex.pdb"
|
|
"V21G","L4","PZA","V","V21",21,"G",1,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",6.521,-0.391,-2.004,2.37287,-2.469,-2.8,70,85,-1.104,9,9,9,0.0517241379310344,"loop",1.76666666666667,4.94,0.0004312203536006,24.2923336141533,24.29233342416,24.2833096922897,14.1977442691074,16,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,2,0,11,15,-0.0990374873353596,-0.517829457364341,0.0864250905091092,-0.420971867007673,-0.732984293193717,0.736842105263158,-0.909390444810544,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.178,-1.062,"9:9","147/150","T:V:C:I",3.19016080361872,0.0035954281300594,1.09565968954933,2.91163472932996,3.91551977432241,465.531063220335,1.38546923679232,0.0007494070007895,3.12528225414311,2.71567844828345,1141.60089496884,0.0001645676755807,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR2516499","ERR2516499","lineage4.1.1","pe","Peru","pnca_p.val21gly","A","-","VAL","VA21","pnca_complex.pdb"
|
|
"V21G","L4","PZA","V","V21",21,"G",1,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",6.521,-0.391,-2.004,2.37287,-2.469,-2.8,70,85,-1.104,9,9,9,0.0517241379310344,"loop",1.76666666666667,4.94,0.0004312203536006,24.2923336141533,24.29233342416,24.2833096922897,14.1977442691074,16,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,2,0,11,15,-0.0990374873353596,-0.517829457364341,0.0864250905091092,-0.420971867007673,-0.732984293193717,0.736842105263158,-0.909390444810544,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.178,-1.062,"9:9","147/150","T:V:C:I",3.19016080361872,0.0035954281300594,1.09565968954933,2.91163472932996,3.91551977432241,465.531063220335,1.38546923679232,0.0007494070007895,3.12528225414311,2.71567844828345,1141.60089496884,0.0001645676755807,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR2516724","ERR2516724","lineage4.1.1","pe","Peru","pnca_p.val21gly","A","-","VAL","VA21","pnca_complex.pdb"
|
|
"V21G","L2","PZA","V","V21",21,"G",1,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",6.521,-0.391,-2.004,2.37287,-2.469,-2.8,70,85,-1.104,9,9,9,0.0517241379310344,"loop",1.76666666666667,4.94,0.0004312203536006,24.2923336141533,24.29233342416,24.2833096922897,14.1977442691074,16,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,2,0,11,15,-0.0990374873353596,-0.517829457364341,0.0864250905091092,-0.420971867007673,-0.732984293193717,0.736842105263158,-0.909390444810544,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.178,-1.062,"9:9","147/150","T:V:C:I",3.19016080361872,0.0035954281300594,1.09565968954933,2.91163472932996,3.91551977432241,465.531063220335,1.38546923679232,0.0007494070007895,3.12528225414311,2.71567844828345,1141.60089496884,0.0001645676755807,"lineage2","dr_mutations_pyrazinamide","GLY",0,"ERS457749","ERR552008_ERR552007","lineage2.2.1","uz","Nukus","pnca_p.val21gly","A","-","VAL","VA21","pnca_complex.pdb"
|
|
"V21I","L4","PZA","V","V21",21,"I",NA,"Other","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",6.521,-0.188,-0.748,-0.568333,-0.271,-0.56,30,66,-1.104,9,9,9,0.0517241379310344,"loop",1.76666666666667,4.94,NA,NA,NA,NA,NA,-14,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-2,0,-2,0,0,0,-2,-2,-0.0476190476190476,-0.19328165374677,-0.1092695916327,-0.0462063086104007,-0.146596858638743,0.315789473684211,-0.909390444810544,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.178,-1.062,"9:9","147/150","T:V:C:I",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage4","other_mutations_pyrazinamide","ILE",0,"ERR1034923","ERR1034923","lineage4.1.2.1","za","South Africa","pnca_p.val21ile","A","-","VAL","VA21","pnca_complex.pdb"
|
|
"T22A","L4","PZA","T","T22",22,"A",NA,"Pre-MDR","OM","hydrophobic","hydrophobic","neutral","non-polar","polar","non-polar",11.195,-0.361,0.118,-0.193269,0.057,-0.37,-93,97,1.546,1,1,127,0.738372093023256,"loop",1.03333333333333,3.6,NA,NA,NA,NA,NA,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,2,0,4,1,-0.0914387031408308,0.100340136054422,-0.0371585403368453,0.0481418918918919,-0.0968586387434555,-1,0.495512820512821,"Destabilising","Stabilising","Stabilising","Stabilising","Destabilising","neutral",0.842,1.712,"2:1","147/150","T:A:S:G:P:D:H:E:Q:N:K:I:R",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage4","other_mutations_pyrazinamide","ALA",0,"SRR6325445","SRR6325445","lineage4.3","us","","pnca_p.thr22ala","A","T","THR","TA22","pnca_complex.pdb"
|
|
"T22A","L3;L4","PZA","T","T22",22,"A",NA,"Pre-MDR","OM","hydrophobic","hydrophobic","neutral","non-polar","polar","non-polar",11.195,-0.361,0.118,-0.193269,0.057,-0.37,-93,97,1.546,1,1,127,0.738372093023256,"loop",1.03333333333333,3.6,NA,NA,NA,NA,NA,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,2,0,4,1,-0.0914387031408308,0.100340136054422,-0.0371585403368453,0.0481418918918919,-0.0968586387434555,-1,0.495512820512821,"Destabilising","Stabilising","Stabilising","Stabilising","Destabilising","neutral",0.842,1.712,"2:1","147/150","T:A:S:G:P:D:H:E:Q:N:K:I:R",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage3;lineage4","other_mutations_pyrazinamide","ALA",0,"SRR6325444","SRR6325444","lineage4.3;lineage3","us","","pnca_p.thr22ala","A","T","THR","TA22","pnca_complex.pdb"
|
|
"T22A","L4","PZA","T","T22",22,"A",NA,"Pre-MDR","OM","hydrophobic","hydrophobic","neutral","non-polar","polar","non-polar",11.195,-0.361,0.118,-0.193269,0.057,-0.37,-93,97,1.546,1,1,127,0.738372093023256,"loop",1.03333333333333,3.6,NA,NA,NA,NA,NA,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,2,0,4,1,-0.0914387031408308,0.100340136054422,-0.0371585403368453,0.0481418918918919,-0.0968586387434555,-1,0.495512820512821,"Destabilising","Stabilising","Stabilising","Stabilising","Destabilising","neutral",0.842,1.712,"2:1","147/150","T:A:S:G:P:D:H:E:Q:N:K:I:R",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage4","other_mutations_pyrazinamide","ALA",0,"SRR6325448","SRR6325448","lineage4.3","us","","pnca_p.thr22ala","A","T","THR","TA22","pnca_complex.pdb"
|
|
"T22P","L2","PZA","T","T22",22,"P",NA,"Other","OM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",11.195,-0.353,0.063,-1.50027,0.006,0,-77,87,1.546,1,1,127,0.738372093023256,"loop",1.03333333333333,3.6,NA,NA,NA,NA,NA,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-4,-0.0894123606889564,0.0535714285714285,-0.288446896869953,0.00506756756756757,0,-0.827956989247312,0.495512820512821,"Destabilising","Stabilising","Stabilising","Stabilising","Stabilising","neutral",0.842,1.712,"2:1","147/150","T:A:S:G:P:D:H:E:Q:N:K:I:R",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage2","other_mutations_pyrazinamide","PRO",0,"ERR502943","ERR502943","lineage2.2","","","pnca_p.thr22pro","A","T","THR","TA22","pnca_complex.pdb"
|
|
"G23V","L2","PZA","G","G23",23,"V",0,"MDR","DM","hydrophobic","hydrophobic","neutral","non-polar","non-polar","non-polar",11.963,-0.147,-0.781,2.85361,-2.833,-1.41,53,75,0.492,3,3,28,0.269230769230769,"loop",-0.5,3.83,7.18700589334483e-05,2.42412778478352,0.0001249735077034,0,1.03410070803344e-29,-2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-3,0,-3,0,-2,0,-5,-13,-0.0372340425531914,-0.201808785529716,0.103934687752679,-0.483034953111679,-0.369109947643979,0.557894736842105,0.157692307692308,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.083,0.59,"5:3","147/150","G:D:H:Y:E:Q:N:R:K",-8.98740878149641,0.940032862253633,119.468044435491,-0.0752285585987751,NA,4692673.51081314,0.384555509373631,1,0,0,188.544222231268,0.999999999999997,"lineage2","dr_mutations_pyrazinamide","VAL",0,"MDR_27149","SRR6824547","lineage2.2.1","cn","China: Weiyang District, Xi'an City, Shaanxi Province","pnca_p.gly23val","A","T","GLY","GA23","pnca_complex.pdb"
|
|
"G24D","L4","PZA","G","G24",24,"D",0,"Pre-XDR","DM","hydrophobic","hydrophilic","neutral","acidic","non-polar","neg",10.19,1.138,-2.197,4.32448,-3.803,-1.77,80,91,-0.971,9,9,0,0,"helix",0.333333333333333,5.96,0.0005030904125341,29.1630847029077,29.1630732435189,29.1293325978315,18.6717493808583,-20,-28,0,0,-28,0,0,0,0,0,0,0,0,0,0,0,0,-10,0,-6,-6,-6,0,-9,-23,0.510313901345291,-0.567700258397933,0.157506974846845,-0.648422847399829,-0.463350785340314,0.842105263157895,-0.799835255354201,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.094,-0.914,"9:8","147/150","G:S:A",3.37290329402598,0.001789077082818,1.07995768762031,3.12318096596746,4.97876379054099,550.894323519243,1.46483345924118,0.0001485295621003,3.828187099348,3.53443753556636,1331.56873199938,1.55265977742841e-05,"lineage4","dr_mutations_pyrazinamide","ASP",0,"ERR2041731","ERR2041731","lineage4.2.2.1","rs","Serbia","pnca_p.gly24asp","A","H","GLY","GA24","pnca_complex.pdb"
|
|
"G24D","L4","PZA","G","G24",24,"D",1,"Pre-XDR","DM","hydrophobic","hydrophilic","neutral","acidic","non-polar","neg",10.19,1.138,-2.197,4.32448,-3.803,-1.77,80,91,-0.971,9,9,0,0,"helix",0.333333333333333,5.96,0.0005030904125341,29.1630847029077,29.1630732435189,29.1293325978315,18.6717493808583,-20,-28,0,0,-28,0,0,0,0,0,0,0,0,0,0,0,0,-10,0,-6,-6,-6,0,-9,-23,0.510313901345291,-0.567700258397933,0.157506974846845,-0.648422847399829,-0.463350785340314,0.842105263157895,-0.799835255354201,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.094,-0.914,"9:8","147/150","G:S:A",3.37290329402598,0.001789077082818,1.07995768762031,3.12318096596746,4.97876379054099,550.894323519243,1.46483345924118,0.0001485295621003,3.828187099348,3.53443753556636,1331.56873199938,1.55265977742841e-05,"lineage4","dr_mutations_pyrazinamide","ASP",0,"ERR2041786","ERR2041786","lineage4.2.2.1","rs","Serbia","pnca_p.gly24asp","A","H","GLY","GA24","pnca_complex.pdb"
|
|
"G24D","L4","PZA","G","G24",24,"D",NA,"MDR","DM","hydrophobic","hydrophilic","neutral","acidic","non-polar","neg",10.19,1.138,-2.197,4.32448,-3.803,-1.77,80,91,-0.971,9,9,0,0,"helix",0.333333333333333,5.96,0.0005030904125341,29.1630847029077,29.1630732435189,29.1293325978315,18.6717493808583,-20,-28,0,0,-28,0,0,0,0,0,0,0,0,0,0,0,0,-10,0,-6,-6,-6,0,-9,-23,0.510313901345291,-0.567700258397933,0.157506974846845,-0.648422847399829,-0.463350785340314,0.842105263157895,-0.799835255354201,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.094,-0.914,"9:8","147/150","G:S:A",3.37290329402598,0.001789077082818,1.07995768762031,3.12318096596746,4.97876379054099,550.894323519243,1.46483345924118,0.0001485295621003,3.828187099348,3.53443753556636,1331.56873199938,1.55265977742841e-05,"lineage4","dr_mutations_pyrazinamide","ASP",0,"ERR3256128","ERR3256128","lineage4.1.1.3","ph","Philippines","pnca_p.gly24asp","A","H","GLY","GA24","pnca_complex.pdb"
|
|
"G24D","L2","PZA","G","G24",24,"D",1,"Pre-XDR","DM","hydrophobic","hydrophilic","neutral","acidic","non-polar","neg",10.19,1.138,-2.197,4.32448,-3.803,-1.77,80,91,-0.971,9,9,0,0,"helix",0.333333333333333,5.96,0.0005030904125341,29.1630847029077,29.1630732435189,29.1293325978315,18.6717493808583,-20,-28,0,0,-28,0,0,0,0,0,0,0,0,0,0,0,0,-10,0,-6,-6,-6,0,-9,-23,0.510313901345291,-0.567700258397933,0.157506974846845,-0.648422847399829,-0.463350785340314,0.842105263157895,-0.799835255354201,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.094,-0.914,"9:8","147/150","G:S:A",3.37290329402598,0.001789077082818,1.07995768762031,3.12318096596746,4.97876379054099,550.894323519243,1.46483345924118,0.0001485295621003,3.828187099348,3.53443753556636,1331.56873199938,1.55265977742841e-05,"lineage2","dr_mutations_pyrazinamide","ASP",0,"MDR_22204","SRR6824596","lineage2.2.1","cn","China: Fengjie County, Chongqing","pnca_p.gly24asp","A","H","GLY","GA24","pnca_complex.pdb"
|
|
"G24D","L4","PZA","G","G24",24,"D",1,"Pre-XDR","DM","hydrophobic","hydrophilic","neutral","acidic","non-polar","neg",10.19,1.138,-2.197,4.32448,-3.803,-1.77,80,91,-0.971,9,9,0,0,"helix",0.333333333333333,5.96,0.0005030904125341,29.1630847029077,29.1630732435189,29.1293325978315,18.6717493808583,-20,-28,0,0,-28,0,0,0,0,0,0,0,0,0,0,0,0,-10,0,-6,-6,-6,0,-9,-23,0.510313901345291,-0.567700258397933,0.157506974846845,-0.648422847399829,-0.463350785340314,0.842105263157895,-0.799835255354201,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.094,-0.914,"9:8","147/150","G:S:A",3.37290329402598,0.001789077082818,1.07995768762031,3.12318096596746,4.97876379054099,550.894323519243,1.46483345924118,0.0001485295621003,3.828187099348,3.53443753556636,1331.56873199938,1.55265977742841e-05,"lineage4","dr_mutations_pyrazinamide","ASP",0,"ERR2041700","ERR2041700","lineage4.2.2.1","rs","Serbia","pnca_p.gly24asp","A","H","GLY","GA24","pnca_complex.pdb"
|
|
"G24D","L4","PZA","G","G24",24,"D",NA,"MDR","DM","hydrophobic","hydrophilic","neutral","acidic","non-polar","neg",10.19,1.138,-2.197,4.32448,-3.803,-1.77,80,91,-0.971,9,9,0,0,"helix",0.333333333333333,5.96,0.0005030904125341,29.1630847029077,29.1630732435189,29.1293325978315,18.6717493808583,-20,-28,0,0,-28,0,0,0,0,0,0,0,0,0,0,0,0,-10,0,-6,-6,-6,0,-9,-23,0.510313901345291,-0.567700258397933,0.157506974846845,-0.648422847399829,-0.463350785340314,0.842105263157895,-0.799835255354201,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.094,-0.914,"9:8","147/150","G:S:A",3.37290329402598,0.001789077082818,1.07995768762031,3.12318096596746,4.97876379054099,550.894323519243,1.46483345924118,0.0001485295621003,3.828187099348,3.53443753556636,1331.56873199938,1.55265977742841e-05,"lineage4","dr_mutations_pyrazinamide","ASP",0,"SAMN02403571","SRR1169134_SRR1172080_SRR1165618_SRR1167371","lineage4.3.3","za","South Africa","pnca_p.gly24asp","A","H","GLY","GA24","pnca_complex.pdb"
|
|
"G24D","L4","PZA","G","G24",24,"D",NA,"MDR","DM","hydrophobic","hydrophilic","neutral","acidic","non-polar","neg",10.19,1.138,-2.197,4.32448,-3.803,-1.77,80,91,-0.971,9,9,0,0,"helix",0.333333333333333,5.96,0.0005030904125341,29.1630847029077,29.1630732435189,29.1293325978315,18.6717493808583,-20,-28,0,0,-28,0,0,0,0,0,0,0,0,0,0,0,0,-10,0,-6,-6,-6,0,-9,-23,0.510313901345291,-0.567700258397933,0.157506974846845,-0.648422847399829,-0.463350785340314,0.842105263157895,-0.799835255354201,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.094,-0.914,"9:8","147/150","G:S:A",3.37290329402598,0.001789077082818,1.07995768762031,3.12318096596746,4.97876379054099,550.894323519243,1.46483345924118,0.0001485295621003,3.828187099348,3.53443753556636,1331.56873199938,1.55265977742841e-05,"lineage4","dr_mutations_pyrazinamide","ASP",0,"SAMN02403570","SRR1169308_SRR1167362_SRR1165700_SRR1169223","lineage4.3.3","za","South Africa","pnca_p.gly24asp","A","H","GLY","GA24","pnca_complex.pdb"
|
|
"G24D","L2","PZA","G","G24",24,"D",1,"Pre-XDR","DM","hydrophobic","hydrophilic","neutral","acidic","non-polar","neg",10.19,1.138,-2.197,4.32448,-3.803,-1.77,80,91,-0.971,9,9,0,0,"helix",0.333333333333333,5.96,0.0005030904125341,29.1630847029077,29.1630732435189,29.1293325978315,18.6717493808583,-20,-28,0,0,-28,0,0,0,0,0,0,0,0,0,0,0,0,-10,0,-6,-6,-6,0,-9,-23,0.510313901345291,-0.567700258397933,0.157506974846845,-0.648422847399829,-0.463350785340314,0.842105263157895,-0.799835255354201,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.094,-0.914,"9:8","147/150","G:S:A",3.37290329402598,0.001789077082818,1.07995768762031,3.12318096596746,4.97876379054099,550.894323519243,1.46483345924118,0.0001485295621003,3.828187099348,3.53443753556636,1331.56873199938,1.55265977742841e-05,"lineage2","dr_mutations_pyrazinamide","ASP",0,"ETB0074","SRR6257009","lineage2.2.1","ru","Russia:St. Petersburg.","pnca_p.gly24asp","A","H","GLY","GA24","pnca_complex.pdb"
|
|
"G24D","L2","PZA","G","G24",24,"D",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","neutral","acidic","non-polar","neg",10.19,1.138,-2.197,4.32448,-3.803,-1.77,80,91,-0.971,9,9,0,0,"helix",0.333333333333333,5.96,0.0005030904125341,29.1630847029077,29.1630732435189,29.1293325978315,18.6717493808583,-20,-28,0,0,-28,0,0,0,0,0,0,0,0,0,0,0,0,-10,0,-6,-6,-6,0,-9,-23,0.510313901345291,-0.567700258397933,0.157506974846845,-0.648422847399829,-0.463350785340314,0.842105263157895,-0.799835255354201,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.094,-0.914,"9:8","147/150","G:S:A",3.37290329402598,0.001789077082818,1.07995768762031,3.12318096596746,4.97876379054099,550.894323519243,1.46483345924118,0.0001485295621003,3.828187099348,3.53443753556636,1331.56873199938,1.55265977742841e-05,"lineage2","dr_mutations_pyrazinamide","ASP",0,"BGI_FJ09132,SRR671754","SRR671754","lineage2.2.1","cn","China","pnca_p.gly24asp","A","H","GLY","GA24","pnca_complex.pdb"
|
|
"G24D","L4","PZA","G","G24",24,"D",1,"Pre-XDR","DM","hydrophobic","hydrophilic","neutral","acidic","non-polar","neg",10.19,1.138,-2.197,4.32448,-3.803,-1.77,80,91,-0.971,9,9,0,0,"helix",0.333333333333333,5.96,0.0005030904125341,29.1630847029077,29.1630732435189,29.1293325978315,18.6717493808583,-20,-28,0,0,-28,0,0,0,0,0,0,0,0,0,0,0,0,-10,0,-6,-6,-6,0,-9,-23,0.510313901345291,-0.567700258397933,0.157506974846845,-0.648422847399829,-0.463350785340314,0.842105263157895,-0.799835255354201,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.094,-0.914,"9:8","147/150","G:S:A",3.37290329402598,0.001789077082818,1.07995768762031,3.12318096596746,4.97876379054099,550.894323519243,1.46483345924118,0.0001485295621003,3.828187099348,3.53443753556636,1331.56873199938,1.55265977742841e-05,"lineage4","dr_mutations_pyrazinamide","ASP",0,"ERR2041780","ERR2041780","lineage4.2.2.1","rs","Serbia","pnca_p.gly24asp","A","H","GLY","GA24","pnca_complex.pdb"
|
|
"G24D","L4","PZA","G","G24",24,"D",1,"MDR","DM","hydrophobic","hydrophilic","neutral","acidic","non-polar","neg",10.19,1.138,-2.197,4.32448,-3.803,-1.77,80,91,-0.971,9,9,0,0,"helix",0.333333333333333,5.96,0.0005030904125341,29.1630847029077,29.1630732435189,29.1293325978315,18.6717493808583,-20,-28,0,0,-28,0,0,0,0,0,0,0,0,0,0,0,0,-10,0,-6,-6,-6,0,-9,-23,0.510313901345291,-0.567700258397933,0.157506974846845,-0.648422847399829,-0.463350785340314,0.842105263157895,-0.799835255354201,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.094,-0.914,"9:8","147/150","G:S:A",3.37290329402598,0.001789077082818,1.07995768762031,3.12318096596746,4.97876379054099,550.894323519243,1.46483345924118,0.0001485295621003,3.828187099348,3.53443753556636,1331.56873199938,1.55265977742841e-05,"lineage4","dr_mutations_pyrazinamide","ASP",0,"ERR2516493","ERR2516493","lineage4.3.4.1","pe","Peru","pnca_p.gly24asp","A","H","GLY","GA24","pnca_complex.pdb"
|
|
"G24D","L4","PZA","G","G24",24,"D",NA,"MDR","DM","hydrophobic","hydrophilic","neutral","acidic","non-polar","neg",10.19,1.138,-2.197,4.32448,-3.803,-1.77,80,91,-0.971,9,9,0,0,"helix",0.333333333333333,5.96,0.0005030904125341,29.1630847029077,29.1630732435189,29.1293325978315,18.6717493808583,-20,-28,0,0,-28,0,0,0,0,0,0,0,0,0,0,0,0,-10,0,-6,-6,-6,0,-9,-23,0.510313901345291,-0.567700258397933,0.157506974846845,-0.648422847399829,-0.463350785340314,0.842105263157895,-0.799835255354201,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.094,-0.914,"9:8","147/150","G:S:A",3.37290329402598,0.001789077082818,1.07995768762031,3.12318096596746,4.97876379054099,550.894323519243,1.46483345924118,0.0001485295621003,3.828187099348,3.53443753556636,1331.56873199938,1.55265977742841e-05,"lineage4","dr_mutations_pyrazinamide","ASP",0,"ERR3256127","ERR3256127","lineage4.1.1.3","ph","Philippines","pnca_p.gly24asp","A","H","GLY","GA24","pnca_complex.pdb"
|
|
"G24D","L4","PZA","G","G24",24,"D",NA,"MDR","DM","hydrophobic","hydrophilic","neutral","acidic","non-polar","neg",10.19,1.138,-2.197,4.32448,-3.803,-1.77,80,91,-0.971,9,9,0,0,"helix",0.333333333333333,5.96,0.0005030904125341,29.1630847029077,29.1630732435189,29.1293325978315,18.6717493808583,-20,-28,0,0,-28,0,0,0,0,0,0,0,0,0,0,0,0,-10,0,-6,-6,-6,0,-9,-23,0.510313901345291,-0.567700258397933,0.157506974846845,-0.648422847399829,-0.463350785340314,0.842105263157895,-0.799835255354201,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.094,-0.914,"9:8","147/150","G:S:A",3.37290329402598,0.001789077082818,1.07995768762031,3.12318096596746,4.97876379054099,550.894323519243,1.46483345924118,0.0001485295621003,3.828187099348,3.53443753556636,1331.56873199938,1.55265977742841e-05,"lineage4","dr_mutations_pyrazinamide","ASP",0,"ERR1193683","ERR1193683","lineage4.3.3","gn","Guinea","pnca_p.gly24asp","A","H","GLY","GA24","pnca_complex.pdb"
|
|
"G24R","L2","PZA","G","G24",24,"R",NA,"XDR","DM","hydrophobic","hydrophilic","neutral","basic","non-polar","pos",10.19,-0.978,-1.19,6.83709,-3.44,-0.67,82,91,-0.971,9,9,0,0,"helix",0.333333333333333,5.96,7.18700589334483e-05,9.70142977291842,188179.926264595,Inf,0.763784339928386,-64,-30,0,0,-30,0,0,0,0,-2,0,0,-2,0,0,0,0,-9,0,-3,-11,-14,0,-17,-29,-0.247720364741641,-0.30749354005168,0.249021700332899,-0.586530264279625,-0.175392670157068,0.863157894736842,-0.799835255354201,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.094,-0.914,"9:8","147/150","G:S:A",12.1451538387262,0.919026337424226,119.468044436218,0.101660271548266,5.01153666064e-06,NA,0.986835744238421,0.170978870202674,0.767057556984365,0.124324963210678,Inf,0.382146811758261,"lineage2","dr_mutations_pyrazinamide","ARG",0,"SAMN02628481","SRR1174894_SRR1183028_SRR1172289_SRR1180230","lineage2.2.1","ir","Iran","pnca_p.gly24arg","A","H","GLY","GA24","pnca_complex.pdb"
|
|
"G24R","L2","PZA","G","G24",24,"R",NA,"XDR","DM","hydrophobic","hydrophilic","neutral","basic","non-polar","pos",10.19,-0.978,-1.19,6.83709,-3.44,-0.67,82,91,-0.971,9,9,0,0,"helix",0.333333333333333,5.96,7.18700589334483e-05,9.70142977291842,188179.926264595,Inf,0.763784339928386,-64,-30,0,0,-30,0,0,0,0,-2,0,0,-2,0,0,0,0,-9,0,-3,-11,-14,0,-17,-29,-0.247720364741641,-0.30749354005168,0.249021700332899,-0.586530264279625,-0.175392670157068,0.863157894736842,-0.799835255354201,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.094,-0.914,"9:8","147/150","G:S:A",12.1451538387262,0.919026337424226,119.468044436218,0.101660271548266,5.01153666064e-06,NA,0.986835744238421,0.170978870202674,0.767057556984365,0.124324963210678,Inf,0.382146811758261,"lineage2","dr_mutations_pyrazinamide","ARG",0,"SAMN02628493","SRR1183029_SRR1172188_SRR1172348_SRR1180211","lineage2.2.1","ir","Iran","pnca_p.gly24arg","A","H","GLY","GA24","pnca_complex.pdb"
|
|
"G24R","L2","PZA","G","G24",24,"R",1,"Pre-XDR","DM","hydrophobic","hydrophilic","neutral","basic","non-polar","pos",10.19,-0.978,-1.19,6.83709,-3.44,-0.67,82,91,-0.971,9,9,0,0,"helix",0.333333333333333,5.96,7.18700589334483e-05,9.70142977291842,188179.926264595,Inf,0.763784339928386,-64,-30,0,0,-30,0,0,0,0,-2,0,0,-2,0,0,0,0,-9,0,-3,-11,-14,0,-17,-29,-0.247720364741641,-0.30749354005168,0.249021700332899,-0.586530264279625,-0.175392670157068,0.863157894736842,-0.799835255354201,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.094,-0.914,"9:8","147/150","G:S:A",12.1451538387262,0.919026337424226,119.468044436218,0.101660271548266,5.01153666064e-06,NA,0.986835744238421,0.170978870202674,0.767057556984365,0.124324963210678,Inf,0.382146811758261,"lineage2","dr_mutations_pyrazinamide","ARG",0,"ERR552774,ERS458297,SAMEA2534895","ERR552774","lineage2.2.1","uz","Nukus","pnca_p.gly24arg","A","H","GLY","GA24","pnca_complex.pdb"
|
|
"G24S","L2","PZA","G","G24",24,"S",1,"XDR","OM","hydrophobic","hydrophilic","neutral","neutral","non-polar","polar",10.19,-0.034,-1.524,-0.205598,-2.078,-1.03,41,71,-0.971,9,9,0,0,"helix",0.333333333333333,5.96,7.18700589334483e-05,9.70142977291842,188179.926264687,Inf,0.763784339928386,-8,0,0,0,0,0,0,0,0,-2,0,-2,0,0,0,0,0,-8,0,-6,-4,-4,0,-9,-17,-0.008611955420466,-0.393798449612403,-0.0395289548565716,-0.354305200341006,-0.269633507853403,0.431578947368421,-0.799835255354201,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.094,-0.914,"9:8","147/150","G:S:A",12.1451538387267,0.919026337424243,119.468044436249,0.101660271548244,5.01153666061174e-06,NA,0.986835744238421,0.170978870202674,0.767057556984365,0.124324963210678,Inf,0.382146811758261,"lineage2","other_mutations_pyrazinamide","SER",0,"ERR2516425","ERR2516425","lineage2.2.1","pe","Peru","pnca_p.gly24ser","A","H","GLY","GA24","pnca_complex.pdb"
|
|
"G24V","L2","PZA","G","G24",24,"V",0,"Pre-XDR","OM","hydrophobic","hydrophobic","neutral","non-polar","non-polar","non-polar",10.19,-1.361,-0.186,2.33197,-2.591,-1.1,70,85,-0.971,9,9,0,0,"helix",0.333333333333333,5.96,7.18700589334483e-05,2.42412778478352,0.0001249735077034,0,1.03410070803344e-29,-8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-9,0,-7,-6,-6,0,-11,-23,-0.344731509625127,-0.0480620155038759,0.0849354234806489,-0.441773231031543,-0.287958115183246,0.736842105263158,-0.799835255354201,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.094,-0.914,"9:8","147/150","G:S:A",-8.98740878149641,0.940032862253632,119.46804443549,-0.0752285585987761,NA,4692673.51081173,0.384555509373631,1,0,0,188.544222231268,0.999999999999997,"lineage2","other_mutations_pyrazinamide","VAL",0,"ERR1035102","ERR1035102","lineage2.2.1","vn","Vietnam","pnca_p.gly24val","A","H","GLY","GA24","pnca_complex.pdb"
|
|
"A25V","L4","PZA","A","A25",25,"V",NA,"Sensitive","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",12.121,-0.995,-0.514,-0.280715,-0.778,-0.65,-66,82,-0.242,6,6,26,0.201550387596899,"helix",1.06666666666667,4.5,NA,NA,NA,NA,NA,-2,0,0,0,0,0,0,0,0,0,0,2,-2,0,0,0,0,1,0,3,-1,0,0,0,3,-0.252026342451874,-0.1328165374677,-0.0539711989540875,-0.132651321398124,-0.170157068062827,-0.709677419354839,-0.199341021416804,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","neutral",-0.411,-0.147,"7:6","147/150","R:K:N:H:E:Y:D:T:S:G:A",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage4","other_mutations_pyrazinamide","VAL",0,"ERR3275947","ERR3275947","lineage4.2.2","nl","Netherlands","pnca_p.ala25val","A","H","ALA","AA25","pnca_complex.pdb"
|
|
"A25V","L4","PZA","A","A25",25,"V",NA,"Sensitive","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",12.121,-0.995,-0.514,-0.280715,-0.778,-0.65,-66,82,-0.242,6,6,26,0.201550387596899,"helix",1.06666666666667,4.5,NA,NA,NA,NA,NA,-2,0,0,0,0,0,0,0,0,0,0,2,-2,0,0,0,0,1,0,3,-1,0,0,0,3,-0.252026342451874,-0.1328165374677,-0.0539711989540875,-0.132651321398124,-0.170157068062827,-0.709677419354839,-0.199341021416804,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","neutral",-0.411,-0.147,"7:6","147/150","R:K:N:H:E:Y:D:T:S:G:A",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage4","other_mutations_pyrazinamide","VAL",0,"ERR3276205","ERR3276205","lineage4.2.2","nl","Netherlands","pnca_p.ala25val","A","H","ALA","AA25","pnca_complex.pdb"
|
|
"A25V","L4","PZA","A","A25",25,"V",NA,"Pre-MDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",12.121,-0.995,-0.514,-0.280715,-0.778,-0.65,-66,82,-0.242,6,6,26,0.201550387596899,"helix",1.06666666666667,4.5,NA,NA,NA,NA,NA,-2,0,0,0,0,0,0,0,0,0,0,2,-2,0,0,0,0,1,0,3,-1,0,0,0,3,-0.252026342451874,-0.1328165374677,-0.0539711989540875,-0.132651321398124,-0.170157068062827,-0.709677419354839,-0.199341021416804,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","neutral",-0.411,-0.147,"7:6","147/150","R:K:N:H:E:Y:D:T:S:G:A",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage4","other_mutations_pyrazinamide","VAL",0,"ERR2179745","ERR2179745","lineage4.2.2","cn","China","pnca_p.ala25val","A","H","ALA","AA25","pnca_complex.pdb"
|
|
"L27P","L4","PZA","L","L27",27,"P",NA,"MDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",9.548,-1.558,-1.624,4.6599,-3.919,-1.07,71,85,-0.385,6,6,11,0.0547263681592039,"helix",2.46666666666667,5.14,0.0007187005893344,19.4567692956558,19.4567531291168,19.4480067941443,23.6697146258566,22,0,0,0,0,0,0,0,0,2,2,0,0,0,0,0,0,-2,4,-4,-2,2,0,6,2,-0.394630192502533,-0.419638242894057,0.169723701367289,-0.668201193520887,-0.280104712041885,0.747368421052632,-0.317133443163097,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.553,-0.332,"7:6","147/150","R:C:I:V:L:T:M",2.96819421438473,0.000173451696941,0.790498020917702,3.75484079130129,4.8718075812224,128.958907982956,1.28907072937786,2.34381123661905e-05,4.63007736799346,3.87828374077737,187.779865627687,1.14368245582331e-06,"lineage4","dr_mutations_pyrazinamide","PRO",0,"SAMN02567730","SRR1166108","lineage4.2.1","ro","Romania","pnca_p.leu27pro","A","H","LEU","LA27","pnca_complex.pdb"
|
|
"L27P","L2","PZA","L","L27",27,"P",1,"Pre-XDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",9.548,-1.558,-1.624,4.6599,-3.919,-1.07,71,85,-0.385,6,6,11,0.0547263681592039,"helix",2.46666666666667,5.14,0.0007187005893344,19.4567692956558,19.4567531291168,19.4480067941443,23.6697146258566,22,0,0,0,0,0,0,0,0,2,2,0,0,0,0,0,0,-2,4,-4,-2,2,0,6,2,-0.394630192502533,-0.419638242894057,0.169723701367289,-0.668201193520887,-0.280104712041885,0.747368421052632,-0.317133443163097,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.553,-0.332,"7:6","147/150","R:C:I:V:L:T:M",2.96819421438473,0.000173451696941,0.790498020917702,3.75484079130129,4.8718075812224,128.958907982956,1.28907072937786,2.34381123661905e-05,4.63007736799346,3.87828374077737,187.779865627687,1.14368245582331e-06,"lineage2","dr_mutations_pyrazinamide","PRO",0,"ERR2517013","ERR2517013","lineage2.2.1","gb","UK","pnca_p.leu27pro","A","H","LEU","LA27","pnca_complex.pdb"
|
|
"L27P","L2","PZA","L","L27",27,"P",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",9.548,-1.558,-1.624,4.6599,-3.919,-1.07,71,85,-0.385,6,6,11,0.0547263681592039,"helix",2.46666666666667,5.14,0.0007187005893344,19.4567692956558,19.4567531291168,19.4480067941443,23.6697146258566,22,0,0,0,0,0,0,0,0,2,2,0,0,0,0,0,0,-2,4,-4,-2,2,0,6,2,-0.394630192502533,-0.419638242894057,0.169723701367289,-0.668201193520887,-0.280104712041885,0.747368421052632,-0.317133443163097,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.553,-0.332,"7:6","147/150","R:C:I:V:L:T:M",2.96819421438473,0.000173451696941,0.790498020917702,3.75484079130129,4.8718075812224,128.958907982956,1.28907072937786,2.34381123661905e-05,4.63007736799346,3.87828374077737,187.779865627687,1.14368245582331e-06,"lineage2","dr_mutations_pyrazinamide","PRO",0,"SAMN09708334","SRR7585404","lineage2.2.1","in","India","pnca_p.leu27pro","A","H","LEU","LA27","pnca_complex.pdb"
|
|
"L27P","L2","PZA","L","L27",27,"P",1,"Pre-XDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",9.548,-1.558,-1.624,4.6599,-3.919,-1.07,71,85,-0.385,6,6,11,0.0547263681592039,"helix",2.46666666666667,5.14,0.0007187005893344,19.4567692956558,19.4567531291168,19.4480067941443,23.6697146258566,22,0,0,0,0,0,0,0,0,2,2,0,0,0,0,0,0,-2,4,-4,-2,2,0,6,2,-0.394630192502533,-0.419638242894057,0.169723701367289,-0.668201193520887,-0.280104712041885,0.747368421052632,-0.317133443163097,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.553,-0.332,"7:6","147/150","R:C:I:V:L:T:M",2.96819421438473,0.000173451696941,0.790498020917702,3.75484079130129,4.8718075812224,128.958907982956,1.28907072937786,2.34381123661905e-05,4.63007736799346,3.87828374077737,187.779865627687,1.14368245582331e-06,"lineage2","dr_mutations_pyrazinamide","PRO",0,"ERR2516825","ERR2516825","lineage2.2.1","gb","UK","pnca_p.leu27pro","A","H","LEU","LA27","pnca_complex.pdb"
|
|
"L27P","L2","PZA","L","L27",27,"P",NA,"MDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",9.548,-1.558,-1.624,4.6599,-3.919,-1.07,71,85,-0.385,6,6,11,0.0547263681592039,"helix",2.46666666666667,5.14,0.0007187005893344,19.4567692956558,19.4567531291168,19.4480067941443,23.6697146258566,22,0,0,0,0,0,0,0,0,2,2,0,0,0,0,0,0,-2,4,-4,-2,2,0,6,2,-0.394630192502533,-0.419638242894057,0.169723701367289,-0.668201193520887,-0.280104712041885,0.747368421052632,-0.317133443163097,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.553,-0.332,"7:6","147/150","R:C:I:V:L:T:M",2.96819421438473,0.000173451696941,0.790498020917702,3.75484079130129,4.8718075812224,128.958907982956,1.28907072937786,2.34381123661905e-05,4.63007736799346,3.87828374077737,187.779865627687,1.14368245582331e-06,"lineage2","dr_mutations_pyrazinamide","PRO",0,"OU33-FMR473","SRR5341240","lineage2.2.1","in","India","pnca_p.leu27pro","A","H","LEU","LA27","pnca_complex.pdb"
|
|
"L27P","L1","PZA","L","L27",27,"P",NA,"MDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",9.548,-1.558,-1.624,4.6599,-3.919,-1.07,71,85,-0.385,6,6,11,0.0547263681592039,"helix",2.46666666666667,5.14,0.0007187005893344,19.4567692956558,19.4567531291168,19.4480067941443,23.6697146258566,22,0,0,0,0,0,0,0,0,2,2,0,0,0,0,0,0,-2,4,-4,-2,2,0,6,2,-0.394630192502533,-0.419638242894057,0.169723701367289,-0.668201193520887,-0.280104712041885,0.747368421052632,-0.317133443163097,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.553,-0.332,"7:6","147/150","R:C:I:V:L:T:M",2.96819421438473,0.000173451696941,0.790498020917702,3.75484079130129,4.8718075812224,128.958907982956,1.28907072937786,2.34381123661905e-05,4.63007736799346,3.87828374077737,187.779865627687,1.14368245582331e-06,"lineage1","dr_mutations_pyrazinamide","PRO",0,"SAMN02598983","SRR1174279_SRR1173257","lineage1.1.2","in","India","pnca_p.leu27pro","A","H","LEU","LA27","pnca_complex.pdb"
|
|
"L27P","L4","PZA","L","L27",27,"P",NA,"Pre-MDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",9.548,-1.558,-1.624,4.6599,-3.919,-1.07,71,85,-0.385,6,6,11,0.0547263681592039,"helix",2.46666666666667,5.14,0.0007187005893344,19.4567692956558,19.4567531291168,19.4480067941443,23.6697146258566,22,0,0,0,0,0,0,0,0,2,2,0,0,0,0,0,0,-2,4,-4,-2,2,0,6,2,-0.394630192502533,-0.419638242894057,0.169723701367289,-0.668201193520887,-0.280104712041885,0.747368421052632,-0.317133443163097,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.553,-0.332,"7:6","147/150","R:C:I:V:L:T:M",2.96819421438473,0.000173451696941,0.790498020917702,3.75484079130129,4.8718075812224,128.958907982956,1.28907072937786,2.34381123661905e-05,4.63007736799346,3.87828374077737,187.779865627687,1.14368245582331e-06,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR2515248","ERR2515248","lineage4.1.1.3","za","South Africa","pnca_p.leu27pro","A","H","LEU","LA27","pnca_complex.pdb"
|
|
"L27P","L2","PZA","L","L27",27,"P",1,"MDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",9.548,-1.558,-1.624,4.6599,-3.919,-1.07,71,85,-0.385,6,6,11,0.0547263681592039,"helix",2.46666666666667,5.14,0.0007187005893344,19.4567692956558,19.4567531291168,19.4480067941443,23.6697146258566,22,0,0,0,0,0,0,0,0,2,2,0,0,0,0,0,0,-2,4,-4,-2,2,0,6,2,-0.394630192502533,-0.419638242894057,0.169723701367289,-0.668201193520887,-0.280104712041885,0.747368421052632,-0.317133443163097,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.553,-0.332,"7:6","147/150","R:C:I:V:L:T:M",2.96819421438473,0.000173451696941,0.790498020917702,3.75484079130129,4.8718075812224,128.958907982956,1.28907072937786,2.34381123661905e-05,4.63007736799346,3.87828374077737,187.779865627687,1.14368245582331e-06,"lineage2","dr_mutations_pyrazinamide","PRO",0,"MDR_17171","SRR6824458","lineage2.2.1","cn","China: Xishui County, Huanggang City, Hubei Province","pnca_p.leu27pro","A","H","LEU","LA27","pnca_complex.pdb"
|
|
"L27P","L2","PZA","L","L27",27,"P",NA,"MDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",9.548,-1.558,-1.624,4.6599,-3.919,-1.07,71,85,-0.385,6,6,11,0.0547263681592039,"helix",2.46666666666667,5.14,0.0007187005893344,19.4567692956558,19.4567531291168,19.4480067941443,23.6697146258566,22,0,0,0,0,0,0,0,0,2,2,0,0,0,0,0,0,-2,4,-4,-2,2,0,6,2,-0.394630192502533,-0.419638242894057,0.169723701367289,-0.668201193520887,-0.280104712041885,0.747368421052632,-0.317133443163097,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.553,-0.332,"7:6","147/150","R:C:I:V:L:T:M",2.96819421438473,0.000173451696941,0.790498020917702,3.75484079130129,4.8718075812224,128.958907982956,1.28907072937786,2.34381123661905e-05,4.63007736799346,3.87828374077737,187.779865627687,1.14368245582331e-06,"lineage2","dr_mutations_pyrazinamide","PRO",0,"OU05-FMRHH4","SRR5341264","lineage2.2.1","in","India","pnca_p.leu27pro","A","H","LEU","LA27","pnca_complex.pdb"
|
|
"L27P","L2","PZA","L","L27",27,"P",NA,"MDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",9.548,-1.558,-1.624,4.6599,-3.919,-1.07,71,85,-0.385,6,6,11,0.0547263681592039,"helix",2.46666666666667,5.14,0.0007187005893344,19.4567692956558,19.4567531291168,19.4480067941443,23.6697146258566,22,0,0,0,0,0,0,0,0,2,2,0,0,0,0,0,0,-2,4,-4,-2,2,0,6,2,-0.394630192502533,-0.419638242894057,0.169723701367289,-0.668201193520887,-0.280104712041885,0.747368421052632,-0.317133443163097,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.553,-0.332,"7:6","147/150","R:C:I:V:L:T:M",2.96819421438473,0.000173451696941,0.790498020917702,3.75484079130129,4.8718075812224,128.958907982956,1.28907072937786,2.34381123661905e-05,4.63007736799346,3.87828374077737,187.779865627687,1.14368245582331e-06,"lineage2","dr_mutations_pyrazinamide","PRO",0,"ERR1023401","ERR1023401","lineage2.2.1.1","","","pnca_p.leu27pro","A","H","LEU","LA27","pnca_complex.pdb"
|
|
"L27P","L2","PZA","L","L27",27,"P",NA,"MDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",9.548,-1.558,-1.624,4.6599,-3.919,-1.07,71,85,-0.385,6,6,11,0.0547263681592039,"helix",2.46666666666667,5.14,0.0007187005893344,19.4567692956558,19.4567531291168,19.4480067941443,23.6697146258566,22,0,0,0,0,0,0,0,0,2,2,0,0,0,0,0,0,-2,4,-4,-2,2,0,6,2,-0.394630192502533,-0.419638242894057,0.169723701367289,-0.668201193520887,-0.280104712041885,0.747368421052632,-0.317133443163097,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.553,-0.332,"7:6","147/150","R:C:I:V:L:T:M",2.96819421438473,0.000173451696941,0.790498020917702,3.75484079130129,4.8718075812224,128.958907982956,1.28907072937786,2.34381123661905e-05,4.63007736799346,3.87828374077737,187.779865627687,1.14368245582331e-06,"lineage2","dr_mutations_pyrazinamide","PRO",0,"OU15-FMR338","SRR5341255","lineage2.2.1","in","India","pnca_p.leu27pro","A","H","LEU","LA27","pnca_complex.pdb"
|
|
"L27P","L2","PZA","L","L27",27,"P",1,"MDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",9.548,-1.558,-1.624,4.6599,-3.919,-1.07,71,85,-0.385,6,6,11,0.0547263681592039,"helix",2.46666666666667,5.14,0.0007187005893344,19.4567692956558,19.4567531291168,19.4480067941443,23.6697146258566,22,0,0,0,0,0,0,0,0,2,2,0,0,0,0,0,0,-2,4,-4,-2,2,0,6,2,-0.394630192502533,-0.419638242894057,0.169723701367289,-0.668201193520887,-0.280104712041885,0.747368421052632,-0.317133443163097,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.553,-0.332,"7:6","147/150","R:C:I:V:L:T:M",2.96819421438473,0.000173451696941,0.790498020917702,3.75484079130129,4.8718075812224,128.958907982956,1.28907072937786,2.34381123661905e-05,4.63007736799346,3.87828374077737,187.779865627687,1.14368245582331e-06,"lineage2","dr_mutations_pyrazinamide","PRO",0,"MDR_17106","SRR6824454","lineage2.2.1","cn","China: Xishui County, Huanggang City, Hubei Province","pnca_p.leu27pro","A","H","LEU","LA27","pnca_complex.pdb"
|
|
"L27P","L3","PZA","L","L27",27,"P",1,"Pre-XDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",9.548,-1.558,-1.624,4.6599,-3.919,-1.07,71,85,-0.385,6,6,11,0.0547263681592039,"helix",2.46666666666667,5.14,0.0007187005893344,19.4567692956558,19.4567531291168,19.4480067941443,23.6697146258566,22,0,0,0,0,0,0,0,0,2,2,0,0,0,0,0,0,-2,4,-4,-2,2,0,6,2,-0.394630192502533,-0.419638242894057,0.169723701367289,-0.668201193520887,-0.280104712041885,0.747368421052632,-0.317133443163097,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.553,-0.332,"7:6","147/150","R:C:I:V:L:T:M",2.96819421438473,0.000173451696941,0.790498020917702,3.75484079130129,4.8718075812224,128.958907982956,1.28907072937786,2.34381123661905e-05,4.63007736799346,3.87828374077737,187.779865627687,1.14368245582331e-06,"lineage3","dr_mutations_pyrazinamide","PRO",0,"ERR2510403","ERR2510403","lineage3","pk","Pakistan","pnca_p.leu27pro","A","H","LEU","LA27","pnca_complex.pdb"
|
|
"L27P","L2","PZA","L","L27",27,"P",1,"Pre-XDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",9.548,-1.558,-1.624,4.6599,-3.919,-1.07,71,85,-0.385,6,6,11,0.0547263681592039,"helix",2.46666666666667,5.14,0.0007187005893344,19.4567692956558,19.4567531291168,19.4480067941443,23.6697146258566,22,0,0,0,0,0,0,0,0,2,2,0,0,0,0,0,0,-2,4,-4,-2,2,0,6,2,-0.394630192502533,-0.419638242894057,0.169723701367289,-0.668201193520887,-0.280104712041885,0.747368421052632,-0.317133443163097,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.553,-0.332,"7:6","147/150","R:C:I:V:L:T:M",2.96819421438473,0.000173451696941,0.790498020917702,3.75484079130129,4.8718075812224,128.958907982956,1.28907072937786,2.34381123661905e-05,4.63007736799346,3.87828374077737,187.779865627687,1.14368245582331e-06,"lineage2","dr_mutations_pyrazinamide","PRO",0,"ERR2199779","ERR2199779","lineage2.2.1","de","Germany","pnca_p.leu27pro","A","H","LEU","LA27","pnca_complex.pdb"
|
|
"L27P","L2","PZA","L","L27",27,"P",NA,"MDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",9.548,-1.558,-1.624,4.6599,-3.919,-1.07,71,85,-0.385,6,6,11,0.0547263681592039,"helix",2.46666666666667,5.14,0.0007187005893344,19.4567692956558,19.4567531291168,19.4480067941443,23.6697146258566,22,0,0,0,0,0,0,0,0,2,2,0,0,0,0,0,0,-2,4,-4,-2,2,0,6,2,-0.394630192502533,-0.419638242894057,0.169723701367289,-0.668201193520887,-0.280104712041885,0.747368421052632,-0.317133443163097,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.553,-0.332,"7:6","147/150","R:C:I:V:L:T:M",2.96819421438473,0.000173451696941,0.790498020917702,3.75484079130129,4.8718075812224,128.958907982956,1.28907072937786,2.34381123661905e-05,4.63007736799346,3.87828374077737,187.779865627687,1.14368245582331e-06,"lineage2","dr_mutations_pyrazinamide","PRO",0,"SRS797271","SRR1723798","lineage2.2.1","cn","China:Hubei","pnca_p.leu27pro","A","H","LEU","LA27","pnca_complex.pdb"
|
|
"L27P","L2","PZA","L","L27",27,"P",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",9.548,-1.558,-1.624,4.6599,-3.919,-1.07,71,85,-0.385,6,6,11,0.0547263681592039,"helix",2.46666666666667,5.14,0.0007187005893344,19.4567692956558,19.4567531291168,19.4480067941443,23.6697146258566,22,0,0,0,0,0,0,0,0,2,2,0,0,0,0,0,0,-2,4,-4,-2,2,0,6,2,-0.394630192502533,-0.419638242894057,0.169723701367289,-0.668201193520887,-0.280104712041885,0.747368421052632,-0.317133443163097,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.553,-0.332,"7:6","147/150","R:C:I:V:L:T:M",2.96819421438473,0.000173451696941,0.790498020917702,3.75484079130129,4.8718075812224,128.958907982956,1.28907072937786,2.34381123661905e-05,4.63007736799346,3.87828374077737,187.779865627687,1.14368245582331e-06,"lineage2","dr_mutations_pyrazinamide","PRO",0,"SAMN09708331","SRR7585401","lineage2.2.1","in","India","pnca_p.leu27pro","A","H","LEU","LA27","pnca_complex.pdb"
|
|
"L27P","L2","PZA","L","L27",27,"P",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",9.548,-1.558,-1.624,4.6599,-3.919,-1.07,71,85,-0.385,6,6,11,0.0547263681592039,"helix",2.46666666666667,5.14,0.0007187005893344,19.4567692956558,19.4567531291168,19.4480067941443,23.6697146258566,22,0,0,0,0,0,0,0,0,2,2,0,0,0,0,0,0,-2,4,-4,-2,2,0,6,2,-0.394630192502533,-0.419638242894057,0.169723701367289,-0.668201193520887,-0.280104712041885,0.747368421052632,-0.317133443163097,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.553,-0.332,"7:6","147/150","R:C:I:V:L:T:M",2.96819421438473,0.000173451696941,0.790498020917702,3.75484079130129,4.8718075812224,128.958907982956,1.28907072937786,2.34381123661905e-05,4.63007736799346,3.87828374077737,187.779865627687,1.14368245582331e-06,"lineage2","dr_mutations_pyrazinamide","PRO",0,"SAMN09708332","SRR7585402","lineage2.2.1","in","India","pnca_p.leu27pro","A","H","LEU","LA27","pnca_complex.pdb"
|
|
"L27P","L2","PZA","L","L27",27,"P",1,"MDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",9.548,-1.558,-1.624,4.6599,-3.919,-1.07,71,85,-0.385,6,6,11,0.0547263681592039,"helix",2.46666666666667,5.14,0.0007187005893344,19.4567692956558,19.4567531291168,19.4480067941443,23.6697146258566,22,0,0,0,0,0,0,0,0,2,2,0,0,0,0,0,0,-2,4,-4,-2,2,0,6,2,-0.394630192502533,-0.419638242894057,0.169723701367289,-0.668201193520887,-0.280104712041885,0.747368421052632,-0.317133443163097,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.553,-0.332,"7:6","147/150","R:C:I:V:L:T:M",2.96819421438473,0.000173451696941,0.790498020917702,3.75484079130129,4.8718075812224,128.958907982956,1.28907072937786,2.34381123661905e-05,4.63007736799346,3.87828374077737,187.779865627687,1.14368245582331e-06,"lineage2","dr_mutations_pyrazinamide","PRO",0,"SRR2100432,SAMN03647605","SRR2100432","lineage2.2.1","","","pnca_p.leu27pro","A","H","LEU","LA27","pnca_complex.pdb"
|
|
"L27P","L2","PZA","L","L27",27,"P",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",9.548,-1.558,-1.624,4.6599,-3.919,-1.07,71,85,-0.385,6,6,11,0.0547263681592039,"helix",2.46666666666667,5.14,0.0007187005893344,19.4567692956558,19.4567531291168,19.4480067941443,23.6697146258566,22,0,0,0,0,0,0,0,0,2,2,0,0,0,0,0,0,-2,4,-4,-2,2,0,6,2,-0.394630192502533,-0.419638242894057,0.169723701367289,-0.668201193520887,-0.280104712041885,0.747368421052632,-0.317133443163097,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.553,-0.332,"7:6","147/150","R:C:I:V:L:T:M",2.96819421438473,0.000173451696941,0.790498020917702,3.75484079130129,4.8718075812224,128.958907982956,1.28907072937786,2.34381123661905e-05,4.63007736799346,3.87828374077737,187.779865627687,1.14368245582331e-06,"lineage2","dr_mutations_pyrazinamide","PRO",0,"ERR752199","ERR752199","lineage2.2.1","th","Thailand","pnca_p.leu27pro","A","H","LEU","LA27","pnca_complex.pdb"
|
|
"L27P","L2","PZA","L","L27",27,"P",0,"MDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",9.548,-1.558,-1.624,4.6599,-3.919,-1.07,71,85,-0.385,6,6,11,0.0547263681592039,"helix",2.46666666666667,5.14,0.0007187005893344,19.4567692956558,19.4567531291168,19.4480067941443,23.6697146258566,22,0,0,0,0,0,0,0,0,2,2,0,0,0,0,0,0,-2,4,-4,-2,2,0,6,2,-0.394630192502533,-0.419638242894057,0.169723701367289,-0.668201193520887,-0.280104712041885,0.747368421052632,-0.317133443163097,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.553,-0.332,"7:6","147/150","R:C:I:V:L:T:M",2.96819421438473,0.000173451696941,0.790498020917702,3.75484079130129,4.8718075812224,128.958907982956,1.28907072937786,2.34381123661905e-05,4.63007736799346,3.87828374077737,187.779865627687,1.14368245582331e-06,"lineage2","dr_mutations_pyrazinamide","PRO",0,"ERR2516536","ERR2516536","lineage2.2.1","nl","Netherlands","pnca_p.leu27pro","A","H","LEU","LA27","pnca_complex.pdb"
|
|
"L27P","L2","PZA","L","L27",27,"P",1,"Pre-XDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",9.548,-1.558,-1.624,4.6599,-3.919,-1.07,71,85,-0.385,6,6,11,0.0547263681592039,"helix",2.46666666666667,5.14,0.0007187005893344,19.4567692956558,19.4567531291168,19.4480067941443,23.6697146258566,22,0,0,0,0,0,0,0,0,2,2,0,0,0,0,0,0,-2,4,-4,-2,2,0,6,2,-0.394630192502533,-0.419638242894057,0.169723701367289,-0.668201193520887,-0.280104712041885,0.747368421052632,-0.317133443163097,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.553,-0.332,"7:6","147/150","R:C:I:V:L:T:M",2.96819421438473,0.000173451696941,0.790498020917702,3.75484079130129,4.8718075812224,128.958907982956,1.28907072937786,2.34381123661905e-05,4.63007736799346,3.87828374077737,187.779865627687,1.14368245582331e-06,"lineage2","dr_mutations_pyrazinamide","PRO",0,"ERR2516511","ERR2516511","lineage2.2.1","pe","Peru","pnca_p.leu27pro","A","H","LEU","LA27","pnca_complex.pdb"
|
|
"L27P","L2","PZA","L","L27",27,"P",0,"Pre-XDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",9.548,-1.558,-1.624,4.6599,-3.919,-1.07,71,85,-0.385,6,6,11,0.0547263681592039,"helix",2.46666666666667,5.14,0.0007187005893344,19.4567692956558,19.4567531291168,19.4480067941443,23.6697146258566,22,0,0,0,0,0,0,0,0,2,2,0,0,0,0,0,0,-2,4,-4,-2,2,0,6,2,-0.394630192502533,-0.419638242894057,0.169723701367289,-0.668201193520887,-0.280104712041885,0.747368421052632,-0.317133443163097,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.553,-0.332,"7:6","147/150","R:C:I:V:L:T:M",2.96819421438473,0.000173451696941,0.790498020917702,3.75484079130129,4.8718075812224,128.958907982956,1.28907072937786,2.34381123661905e-05,4.63007736799346,3.87828374077737,187.779865627687,1.14368245582331e-06,"lineage2","dr_mutations_pyrazinamide","PRO",0,"ERR234608,0541P-sc-2012-10-11T13:36:41Z-1494094","ERR234608","lineage2.2.1","ru","Russia,Samara","pnca_p.leu27pro","A","H","LEU","LA27","pnca_complex.pdb"
|
|
"L27Q","L4","PZA","L","L27",27,"Q",NA,"MDR","OM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",9.548,0.134,-1.081,2.24048,-3.309,-0.81,45,71,-0.385,6,6,11,0.0547263681592039,"helix",2.46666666666667,5.14,NA,NA,NA,NA,NA,-8,0,0,0,0,0,0,0,0,-2,0,-2,0,0,0,0,0,-10,0,-6,-4,2,0,2,-2,0.0600896860986547,-0.279328165374677,0.0816031585311665,-0.564194373401535,-0.212041884816754,0.473684210526316,-0.317133443163097,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.553,-0.332,"7:6","147/150","R:C:I:V:L:T:M",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage4","other_mutations_pyrazinamide","GLN",0,"SAMN02628478","SRR1174323_SRR1172944","lineage4.4","ir","Iran","pnca_p.leu27gln","A","H","LEU","LA27","pnca_complex.pdb"
|
|
"L27Q","L4","PZA","L","L27",27,"Q",NA,"MDR","OM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",9.548,0.134,-1.081,2.24048,-3.309,-0.81,45,71,-0.385,6,6,11,0.0547263681592039,"helix",2.46666666666667,5.14,NA,NA,NA,NA,NA,-8,0,0,0,0,0,0,0,0,-2,0,-2,0,0,0,0,0,-10,0,-6,-4,2,0,2,-2,0.0600896860986547,-0.279328165374677,0.0816031585311665,-0.564194373401535,-0.212041884816754,0.473684210526316,-0.317133443163097,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.553,-0.332,"7:6","147/150","R:C:I:V:L:T:M",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage4","other_mutations_pyrazinamide","GLN",0,"SAMN02628529","SRR1180218_SRR1172088_SRR1183118_SRR1172158","lineage4.4","ir","Iran","pnca_p.leu27gln","A","H","LEU","LA27","pnca_complex.pdb"
|
|
"L27R","L4","PZA","L","L27",27,"R",1,"Pre-XDR","OM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",9.548,-1.016,-0.738,2.15593,-3.558,-0.1,69,80,-0.385,6,6,11,0.0547263681592039,"helix",2.46666666666667,5.14,0.0001437401178668,4.85029436501262,4.85029432717734,4.84956447904112,0.0881192621863332,-46,-20,0,-2,-18,0,0,0,0,0,0,-2,0,0,0,0,0,-3,0,-3,-1,0,0,2,4,-0.257345491388045,-0.190697674418605,0.0785236634882247,-0.606649616368286,-0.0261780104712041,0.726315789473684,-0.317133443163097,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.553,-0.332,"7:6","147/150","R:C:I:V:L:T:M",1.57903938912402,0.264247566376723,1.41439286276584,1.11640791656443,0.191756076673649,122.683760399218,0.685768096792206,0.312734154310187,0.504824686014995,0.061763864579114,379.558337204203,0.766581879696361,"lineage4","other_mutations_pyrazinamide","ARG",0,"ERR2516687","ERR2516687","lineage4.3.4.2","pe","Peru","pnca_p.leu27arg","A","H","LEU","LA27","pnca_complex.pdb"
|
|
"L27R","L2","PZA","L","L27",27,"R",NA,"Pre-XDR","OM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",9.548,-1.016,-0.738,2.15593,-3.558,-0.1,69,80,-0.385,6,6,11,0.0547263681592039,"helix",2.46666666666667,5.14,0.0001437401178668,4.85029436501262,4.85029432717734,4.84956447904112,0.0881192621863332,-46,-20,0,-2,-18,0,0,0,0,0,0,-2,0,0,0,0,0,-3,0,-3,-1,0,0,2,4,-0.257345491388045,-0.190697674418605,0.0785236634882247,-0.606649616368286,-0.0261780104712041,0.726315789473684,-0.317133443163097,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.553,-0.332,"7:6","147/150","R:C:I:V:L:T:M",1.57903938912402,0.264247566376723,1.41439286276584,1.11640791656443,0.191756076673649,122.683760399218,0.685768096792206,0.312734154310187,0.504824686014995,0.061763864579114,379.558337204203,0.766581879696361,"lineage2","other_mutations_pyrazinamide","ARG",0,"SRS935923,SAMN03653314","SRR2024897","lineage2.2.1","cn","China","pnca_p.leu27arg","A","H","LEU","LA27","pnca_complex.pdb"
|
|
"L27R","L2","PZA","L","L27",27,"R",0,"XDR","OM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",9.548,-1.016,-0.738,2.15593,-3.558,-0.1,69,80,-0.385,6,6,11,0.0547263681592039,"helix",2.46666666666667,5.14,0.0001437401178668,4.85029436501262,4.85029432717734,4.84956447904112,0.0881192621863332,-46,-20,0,-2,-18,0,0,0,0,0,0,-2,0,0,0,0,0,-3,0,-3,-1,0,0,2,4,-0.257345491388045,-0.190697674418605,0.0785236634882247,-0.606649616368286,-0.0261780104712041,0.726315789473684,-0.317133443163097,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.553,-0.332,"7:6","147/150","R:C:I:V:L:T:M",1.57903938912402,0.264247566376723,1.41439286276584,1.11640791656443,0.191756076673649,122.683760399218,0.685768096792206,0.312734154310187,0.504824686014995,0.061763864579114,379.558337204203,0.766581879696361,"lineage2","other_mutations_pyrazinamide","ARG",0,"ERR067717,1605W-sc-2011-09-07T13:20:12Z-1276564","ERR067717","lineage2.2.1","ru","Russia,Samara","pnca_p.leu27arg","A","H","LEU","LA27","pnca_complex.pdb"
|
|
"A28D","L2","PZA","A","A28",28,"D",1,"MDR","DM","hydrophobic","hydrophilic","non-polar","acidic","non-polar","neg",12.7,0.554,-2.8,3.01687,-4.44,-1.38,67,80,-0.564,7,7,0,0,"helix",0.366666666666667,6.48,7.18700589334483e-05,9.70142977291842,188179.926264663,Inf,0.763784339928386,-8,-52,0,0,-52,0,0,0,0,0,0,4,-4,0,0,0,0,-7,0,-3,-2,-8,0,-10,-5,0.248430493273542,-0.723514211886305,0.10988097232643,-0.757033248081841,-0.361256544502618,0.705263157894737,-0.464579901153213,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.485,"8:7","147/150","P:A:I:V:L",12.1451538387266,0.91902633742424,119.468044436242,0.101660271548249,5.01153666061778e-06,NA,0.986835744238421,0.170978870202674,0.767057556984365,0.124324963210678,Inf,0.382146811758261,"lineage2","dr_mutations_pyrazinamide","ASP",0,"SAMN10961375","SRR8651616","lineage2.2.1","cn","China:Wenzhou","pnca_p.ala28asp","A","H","ALA","AA28","pnca_complex.pdb"
|
|
"A28T","L4","PZA","A","A28",28,"T",NA,"MDR","OM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",12.7,-0.289,-1.901,-0.611286,-2.577,-1.74,41,71,-0.564,7,7,0,0,"helix",0.366666666666667,6.48,NA,NA,NA,NA,NA,-2,0,0,0,0,0,0,0,0,-2,0,-2,0,0,0,0,0,-8,0,-2,-6,-8,0,-4,-5,-0.0732016210739615,-0.491214470284238,-0.117527878181958,-0.439386189258312,-0.455497382198953,0.431578947368421,-0.464579901153213,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.728,-0.485,"8:7","147/150","P:A:I:V:L",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage4","other_mutations_pyrazinamide","THR",0,"ERR2516621","ERR2516621","lineage4.1.1.3","nl","Netherlands","pnca_p.ala28thr","A","H","ALA","AA28","pnca_complex.pdb"
|
|
"A30V","L1","PZA","A","A30",30,"V",NA,"Sensitive","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",16.46,-0.846,-0.401,-0.154342,-0.442,-0.7,-76,87,1.207,1,1,37,0.286821705426357,"helix",0.6,3.88,7.18700589334483e-05,9.70142977291842,188179.9262646,Inf,0.763784339928386,-4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-5,0,-5,-4,0,0,0,-3,-0.214285714285714,-0.103617571059432,-0.0296743059294009,-0.0753623188405797,-0.183246073298429,-0.817204301075269,0.386858974358974,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","neutral",0.59,1.183,"3:1","147/150","Q:E:Y:K:I:R:V:L:N:P:M:A:G:T:D",12.1451538387263,0.919026337424228,119.468044436221,0.101660271548264,5.01153666063734e-06,NA,0.986835744238421,0.170978870202674,0.767057556984365,0.124324963210678,Inf,0.382146811758261,"lineage1","other_mutations_pyrazinamide","VAL",0,"ERR3256161","ERR3256161","lineage1.2.1","ph","Philippines","pnca_p.ala30val","A","H","ALA","AA30","pnca_complex.pdb"
|
|
"A30V","L4","PZA","A","A30",30,"V",1,"Other","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",16.46,-0.846,-0.401,-0.154342,-0.442,-0.7,-76,87,1.207,1,1,37,0.286821705426357,"helix",0.6,3.88,7.18700589334483e-05,9.70142977291842,188179.9262646,Inf,0.763784339928386,-4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-5,0,-5,-4,0,0,0,-3,-0.214285714285714,-0.103617571059432,-0.0296743059294009,-0.0753623188405797,-0.183246073298429,-0.817204301075269,0.386858974358974,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","neutral",0.59,1.183,"3:1","147/150","Q:E:Y:K:I:R:V:L:N:P:M:A:G:T:D",12.1451538387263,0.919026337424228,119.468044436221,0.101660271548264,5.01153666063734e-06,NA,0.986835744238421,0.170978870202674,0.767057556984365,0.124324963210678,Inf,0.382146811758261,"lineage4","other_mutations_pyrazinamide","VAL",0,"ERS457272","ERR551343_ERR551342","lineage4.1.2.1","uz","Nukus","pnca_p.ala30val","A","H","ALA","AA30","pnca_complex.pdb"
|
|
"I31S","L2","PZA","I","I31",31,"S",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",11.654,-0.329,-3.608,4.81248,-3.395,-3.34,60,80,-0.562,7,7,0,0,"helix",1.83333333333333,6.99,0.0004312203536006,58.3312262958281,1393450.94022095,Inf,23.547488635408,28,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,0,0,0,0,2,0,2,2,-0.0833333333333333,-0.932299741602067,0.17528099709351,-0.578857630008525,-0.87434554973822,0.631578947368421,-0.462932454695222,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.485,"8:7","147/150","I:L:V:T:A",14.1472939191279,0.915018435774967,132.576060676205,0.106710773023195,4.17896182050295,NA,1.7659011066874,2.48532104922106e-05,4.60461750194108,5.71767556863798,Inf,1.21868387173808e-06,"lineage2","dr_mutations_pyrazinamide","SER",0,"ETB0068","SRR6257006","lineage2.2.1","ru","Russia:Altaysky Krai","pnca_p.ile31ser","A","H","ILE","IA31","pnca_complex.pdb"
|
|
"I31S","L2","PZA","I","I31",31,"S",1,"XDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",11.654,-0.329,-3.608,4.81248,-3.395,-3.34,60,80,-0.562,7,7,0,0,"helix",1.83333333333333,6.99,0.0004312203536006,58.3312262958281,1393450.94022095,Inf,23.547488635408,28,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,0,0,0,0,2,0,2,2,-0.0833333333333333,-0.932299741602067,0.17528099709351,-0.578857630008525,-0.87434554973822,0.631578947368421,-0.462932454695222,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.485,"8:7","147/150","I:L:V:T:A",14.1472939191279,0.915018435774967,132.576060676205,0.106710773023195,4.17896182050295,NA,1.7659011066874,2.48532104922106e-05,4.60461750194108,5.71767556863798,Inf,1.21868387173808e-06,"lineage2","dr_mutations_pyrazinamide","SER",0,"ERR2516798","ERR2516798","lineage2.2.1","gb","UK","pnca_p.ile31ser","A","H","ILE","IA31","pnca_complex.pdb"
|
|
"I31S","L2","PZA","I","I31",31,"S",1,"XDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",11.654,-0.329,-3.608,4.81248,-3.395,-3.34,60,80,-0.562,7,7,0,0,"helix",1.83333333333333,6.99,0.0004312203536006,58.3312262958281,1393450.94022095,Inf,23.547488635408,28,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,0,0,0,0,2,0,2,2,-0.0833333333333333,-0.932299741602067,0.17528099709351,-0.578857630008525,-0.87434554973822,0.631578947368421,-0.462932454695222,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.485,"8:7","147/150","I:L:V:T:A",14.1472939191279,0.915018435774967,132.576060676205,0.106710773023195,4.17896182050295,NA,1.7659011066874,2.48532104922106e-05,4.60461750194108,5.71767556863798,Inf,1.21868387173808e-06,"lineage2","dr_mutations_pyrazinamide","SER",0,"ERS2592810","ERR2677467","lineage2.2.1","de","Germany","pnca_p.ile31ser","A","H","ILE","IA31","pnca_complex.pdb"
|
|
"I31S","L2","PZA","I","I31",31,"S",NA,"MDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",11.654,-0.329,-3.608,4.81248,-3.395,-3.34,60,80,-0.562,7,7,0,0,"helix",1.83333333333333,6.99,0.0004312203536006,58.3312262958281,1393450.94022095,Inf,23.547488635408,28,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,0,0,0,0,2,0,2,2,-0.0833333333333333,-0.932299741602067,0.17528099709351,-0.578857630008525,-0.87434554973822,0.631578947368421,-0.462932454695222,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.485,"8:7","147/150","I:L:V:T:A",14.1472939191279,0.915018435774967,132.576060676205,0.106710773023195,4.17896182050295,NA,1.7659011066874,2.48532104922106e-05,4.60461750194108,5.71767556863798,Inf,1.21868387173808e-06,"lineage2","dr_mutations_pyrazinamide","SER",0,"ERR1213851","ERR1213851","lineage2.2.2","kr","South Korea","pnca_p.ile31ser","A","H","ILE","IA31","pnca_complex.pdb"
|
|
"I31S","L3","PZA","I","I31",31,"S",1,"MDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",11.654,-0.329,-3.608,4.81248,-3.395,-3.34,60,80,-0.562,7,7,0,0,"helix",1.83333333333333,6.99,0.0004312203536006,58.3312262958281,1393450.94022095,Inf,23.547488635408,28,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,0,0,0,0,2,0,2,2,-0.0833333333333333,-0.932299741602067,0.17528099709351,-0.578857630008525,-0.87434554973822,0.631578947368421,-0.462932454695222,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.485,"8:7","147/150","I:L:V:T:A",14.1472939191279,0.915018435774967,132.576060676205,0.106710773023195,4.17896182050295,NA,1.7659011066874,2.48532104922106e-05,4.60461750194108,5.71767556863798,Inf,1.21868387173808e-06,"lineage3","dr_mutations_pyrazinamide","SER",0,"ERR2510644","ERR2510644","lineage3","pk","Pakistan","pnca_p.ile31ser","A","H","ILE","IA31","pnca_complex.pdb"
|
|
"I31S","L2","PZA","I","I31",31,"S",1,"XDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",11.654,-0.329,-3.608,4.81248,-3.395,-3.34,60,80,-0.562,7,7,0,0,"helix",1.83333333333333,6.99,0.0004312203536006,58.3312262958281,1393450.94022095,Inf,23.547488635408,28,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,0,0,0,0,2,0,2,2,-0.0833333333333333,-0.932299741602067,0.17528099709351,-0.578857630008525,-0.87434554973822,0.631578947368421,-0.462932454695222,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.485,"8:7","147/150","I:L:V:T:A",14.1472939191279,0.915018435774967,132.576060676205,0.106710773023195,4.17896182050295,NA,1.7659011066874,2.48532104922106e-05,4.60461750194108,5.71767556863798,Inf,1.21868387173808e-06,"lineage2","dr_mutations_pyrazinamide","SER",0,"ERS2592766","ERR2677418","lineage2.2.1","de","Germany","pnca_p.ile31ser","A","H","ILE","IA31","pnca_complex.pdb"
|
|
"I31S","L2","PZA","I","I31",31,"S",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",11.654,-0.329,-3.608,4.81248,-3.395,-3.34,60,80,-0.562,7,7,0,0,"helix",1.83333333333333,6.99,0.0004312203536006,58.3312262958281,1393450.94022095,Inf,23.547488635408,28,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,0,0,0,0,2,0,2,2,-0.0833333333333333,-0.932299741602067,0.17528099709351,-0.578857630008525,-0.87434554973822,0.631578947368421,-0.462932454695222,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.485,"8:7","147/150","I:L:V:T:A",14.1472939191279,0.915018435774967,132.576060676205,0.106710773023195,4.17896182050295,NA,1.7659011066874,2.48532104922106e-05,4.60461750194108,5.71767556863798,Inf,1.21868387173808e-06,"lineage2","dr_mutations_pyrazinamide","SER",0,"DRR184906","DRR184906","lineage2.2.1","vn","Vietnam","pnca_p.ile31ser","A","H","ILE","IA31","pnca_complex.pdb"
|
|
"I31S","L2","PZA","I","I31",31,"S",1,"MDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",11.654,-0.329,-3.608,4.81248,-3.395,-3.34,60,80,-0.562,7,7,0,0,"helix",1.83333333333333,6.99,0.0004312203536006,58.3312262958281,1393450.94022095,Inf,23.547488635408,28,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,0,0,0,0,2,0,2,2,-0.0833333333333333,-0.932299741602067,0.17528099709351,-0.578857630008525,-0.87434554973822,0.631578947368421,-0.462932454695222,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.485,"8:7","147/150","I:L:V:T:A",14.1472939191279,0.915018435774967,132.576060676205,0.106710773023195,4.17896182050295,NA,1.7659011066874,2.48532104922106e-05,4.60461750194108,5.71767556863798,Inf,1.21868387173808e-06,"lineage2","dr_mutations_pyrazinamide","SER",0,"ERR2515705","ERR2515705","lineage2.2.2","za","South Africa","pnca_p.ile31ser","A","H","ILE","IA31","pnca_complex.pdb"
|
|
"I31S","L4","PZA","I","I31",31,"S",NA,"MDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",11.654,-0.329,-3.608,4.81248,-3.395,-3.34,60,80,-0.562,7,7,0,0,"helix",1.83333333333333,6.99,0.0004312203536006,58.3312262958281,1393450.94022095,Inf,23.547488635408,28,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,0,0,0,0,2,0,2,2,-0.0833333333333333,-0.932299741602067,0.17528099709351,-0.578857630008525,-0.87434554973822,0.631578947368421,-0.462932454695222,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.485,"8:7","147/150","I:L:V:T:A",14.1472939191279,0.915018435774967,132.576060676205,0.106710773023195,4.17896182050295,NA,1.7659011066874,2.48532104922106e-05,4.60461750194108,5.71767556863798,Inf,1.21868387173808e-06,"lineage4","dr_mutations_pyrazinamide","SER",0,"ERR2516502","ERR2516502","lineage4.8","pe","Peru","pnca_p.ile31ser","A","H","ILE","IA31","pnca_complex.pdb"
|
|
"I31S","L2","PZA","I","I31",31,"S",1,"XDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",11.654,-0.329,-3.608,4.81248,-3.395,-3.34,60,80,-0.562,7,7,0,0,"helix",1.83333333333333,6.99,0.0004312203536006,58.3312262958281,1393450.94022095,Inf,23.547488635408,28,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,0,0,0,0,2,0,2,2,-0.0833333333333333,-0.932299741602067,0.17528099709351,-0.578857630008525,-0.87434554973822,0.631578947368421,-0.462932454695222,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.485,"8:7","147/150","I:L:V:T:A",14.1472939191279,0.915018435774967,132.576060676205,0.106710773023195,4.17896182050295,NA,1.7659011066874,2.48532104922106e-05,4.60461750194108,5.71767556863798,Inf,1.21868387173808e-06,"lineage2","dr_mutations_pyrazinamide","SER",0,"ERR2517047","ERR2517047","lineage2.2.1","gb","UK","pnca_p.ile31ser","A","H","ILE","IA31","pnca_complex.pdb"
|
|
"I31T","L2","PZA","I","I31",31,"T",NA,"MDR","OM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",11.654,-0.358,-3.12,3.06922,-3.102,-3.05,62,80,-0.562,7,7,0,0,"helix",1.83333333333333,6.99,7.18700589334483e-05,2.42412778478352,0.0001249735077034,0,1.03410070803344e-29,24,0,0,0,0,0,0,0,0,-2,0,-2,0,0,0,0,0,-5,0,-5,0,2,0,2,0,-0.0906788247213779,-0.806201550387597,0.111787673278506,-0.528900255754476,-0.798429319371728,0.652631578947368,-0.462932454695222,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.485,"8:7","147/150","I:L:V:T:A",-8.98740878149641,0.940032862253633,119.46804443549,-0.0752285585987758,NA,4692673.51081066,0.384555509373631,1,0,0,188.544222231268,0.999999999999997,"lineage2","other_mutations_pyrazinamide","THR",0,"SAMN07236365,SRR5709965","SRR5709965","lineage2.2.1","th","Thailand","pnca_p.ile31thr","A","H","ILE","IA31","pnca_complex.pdb"
|
|
"I31T","L2","PZA","I","I31",31,"T",NA,"MDR","OM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",11.654,-0.358,-3.12,3.06922,-3.102,-3.05,62,80,-0.562,7,7,0,0,"helix",1.83333333333333,6.99,7.18700589334483e-05,2.42412778478352,0.0001249735077034,0,1.03410070803344e-29,24,0,0,0,0,0,0,0,0,-2,0,-2,0,0,0,0,0,-5,0,-5,0,2,0,2,0,-0.0906788247213779,-0.806201550387597,0.111787673278506,-0.528900255754476,-0.798429319371728,0.652631578947368,-0.462932454695222,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.485,"8:7","147/150","I:L:V:T:A",-8.98740878149641,0.940032862253633,119.46804443549,-0.0752285585987758,NA,4692673.51081066,0.384555509373631,1,0,0,188.544222231268,0.999999999999997,"lineage2","other_mutations_pyrazinamide","THR",0,"SRR5709817,SAMN07236336","SRR5709817","lineage2.2.1","th","Thailand","pnca_p.ile31thr","A","H","ILE","IA31","pnca_complex.pdb"
|
|
"I31T","L4","PZA","I","I31",31,"T",NA,"Sensitive","OM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",11.654,-0.358,-3.12,3.06922,-3.102,-3.05,62,80,-0.562,7,7,0,0,"helix",1.83333333333333,6.99,7.18700589334483e-05,2.42412778478352,0.0001249735077034,0,1.03410070803344e-29,24,0,0,0,0,0,0,0,0,-2,0,-2,0,0,0,0,0,-5,0,-5,0,2,0,2,0,-0.0906788247213779,-0.806201550387597,0.111787673278506,-0.528900255754476,-0.798429319371728,0.652631578947368,-0.462932454695222,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.485,"8:7","147/150","I:L:V:T:A",-8.98740878149641,0.940032862253633,119.46804443549,-0.0752285585987758,NA,4692673.51081066,0.384555509373631,1,0,0,188.544222231268,0.999999999999997,"lineage4","other_mutations_pyrazinamide","THR",0,"ERR2229041","ERR2229041","lineage4.8","dk","","pnca_p.ile31thr","A","H","ILE","IA31","pnca_complex.pdb"
|
|
"I31T","L2","PZA","I","I31",31,"T",NA,"MDR","OM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",11.654,-0.358,-3.12,3.06922,-3.102,-3.05,62,80,-0.562,7,7,0,0,"helix",1.83333333333333,6.99,7.18700589334483e-05,2.42412778478352,0.0001249735077034,0,1.03410070803344e-29,24,0,0,0,0,0,0,0,0,-2,0,-2,0,0,0,0,0,-5,0,-5,0,2,0,2,0,-0.0906788247213779,-0.806201550387597,0.111787673278506,-0.528900255754476,-0.798429319371728,0.652631578947368,-0.462932454695222,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.485,"8:7","147/150","I:L:V:T:A",-8.98740878149641,0.940032862253633,119.46804443549,-0.0752285585987758,NA,4692673.51081066,0.384555509373631,1,0,0,188.544222231268,0.999999999999997,"lineage2","other_mutations_pyrazinamide","THR",0,"SRR5709930,SAMN07236357","SRR5709930","lineage2.2.1","th","Thailand","pnca_p.ile31thr","A","H","ILE","IA31","pnca_complex.pdb"
|
|
"I31T","L2","PZA","I","I31",31,"T",NA,"MDR","OM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",11.654,-0.358,-3.12,3.06922,-3.102,-3.05,62,80,-0.562,7,7,0,0,"helix",1.83333333333333,6.99,7.18700589334483e-05,2.42412778478352,0.0001249735077034,0,1.03410070803344e-29,24,0,0,0,0,0,0,0,0,-2,0,-2,0,0,0,0,0,-5,0,-5,0,2,0,2,0,-0.0906788247213779,-0.806201550387597,0.111787673278506,-0.528900255754476,-0.798429319371728,0.652631578947368,-0.462932454695222,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.485,"8:7","147/150","I:L:V:T:A",-8.98740878149641,0.940032862253633,119.46804443549,-0.0752285585987758,NA,4692673.51081066,0.384555509373631,1,0,0,188.544222231268,0.999999999999997,"lineage2","other_mutations_pyrazinamide","THR",0,"SRR5837707,SAMN07360952","SRR5837707","lineage2.2.1","th","Thailand","pnca_p.ile31thr","A","H","ILE","IA31","pnca_complex.pdb"
|
|
"I31T","L2","PZA","I","I31",31,"T",NA,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",11.654,-0.358,-3.12,3.06922,-3.102,-3.05,62,80,-0.562,7,7,0,0,"helix",1.83333333333333,6.99,7.18700589334483e-05,2.42412778478352,0.0001249735077034,0,1.03410070803344e-29,24,0,0,0,0,0,0,0,0,-2,0,-2,0,0,0,0,0,-5,0,-5,0,2,0,2,0,-0.0906788247213779,-0.806201550387597,0.111787673278506,-0.528900255754476,-0.798429319371728,0.652631578947368,-0.462932454695222,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.485,"8:7","147/150","I:L:V:T:A",-8.98740878149641,0.940032862253633,119.46804443549,-0.0752285585987758,NA,4692673.51081066,0.384555509373631,1,0,0,188.544222231268,0.999999999999997,"lineage2","other_mutations_pyrazinamide","THR",0,"SAMN07236268,SRR5709754","SRR5709754","lineage2.2.1","th","Thailand","pnca_p.ile31thr","A","H","ILE","IA31","pnca_complex.pdb"
|
|
"I31T","L2","PZA","I","I31",31,"T",NA,"MDR","OM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",11.654,-0.358,-3.12,3.06922,-3.102,-3.05,62,80,-0.562,7,7,0,0,"helix",1.83333333333333,6.99,7.18700589334483e-05,2.42412778478352,0.0001249735077034,0,1.03410070803344e-29,24,0,0,0,0,0,0,0,0,-2,0,-2,0,0,0,0,0,-5,0,-5,0,2,0,2,0,-0.0906788247213779,-0.806201550387597,0.111787673278506,-0.528900255754476,-0.798429319371728,0.652631578947368,-0.462932454695222,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.485,"8:7","147/150","I:L:V:T:A",-8.98740878149641,0.940032862253633,119.46804443549,-0.0752285585987758,NA,4692673.51081066,0.384555509373631,1,0,0,188.544222231268,0.999999999999997,"lineage2","other_mutations_pyrazinamide","THR",0,"SRR5709951,SAMN07236418","SRR5709951","lineage2.2.1","th","Thailand","pnca_p.ile31thr","A","H","ILE","IA31","pnca_complex.pdb"
|
|
"I31T","L2","PZA","I","I31",31,"T",NA,"MDR","OM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",11.654,-0.358,-3.12,3.06922,-3.102,-3.05,62,80,-0.562,7,7,0,0,"helix",1.83333333333333,6.99,7.18700589334483e-05,2.42412778478352,0.0001249735077034,0,1.03410070803344e-29,24,0,0,0,0,0,0,0,0,-2,0,-2,0,0,0,0,0,-5,0,-5,0,2,0,2,0,-0.0906788247213779,-0.806201550387597,0.111787673278506,-0.528900255754476,-0.798429319371728,0.652631578947368,-0.462932454695222,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.485,"8:7","147/150","I:L:V:T:A",-8.98740878149641,0.940032862253633,119.46804443549,-0.0752285585987758,NA,4692673.51081066,0.384555509373631,1,0,0,188.544222231268,0.999999999999997,"lineage2","other_mutations_pyrazinamide","THR",0,"SRR5709877,SAMN07236401","SRR5709877","lineage2.2.1","th","Thailand","pnca_p.ile31thr","A","H","ILE","IA31","pnca_complex.pdb"
|
|
"I31T","L3","PZA","I","I31",31,"T",0,"MDR","OM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",11.654,-0.358,-3.12,3.06922,-3.102,-3.05,62,80,-0.562,7,7,0,0,"helix",1.83333333333333,6.99,7.18700589334483e-05,2.42412778478352,0.0001249735077034,0,1.03410070803344e-29,24,0,0,0,0,0,0,0,0,-2,0,-2,0,0,0,0,0,-5,0,-5,0,2,0,2,0,-0.0906788247213779,-0.806201550387597,0.111787673278506,-0.528900255754476,-0.798429319371728,0.652631578947368,-0.462932454695222,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.485,"8:7","147/150","I:L:V:T:A",-8.98740878149641,0.940032862253633,119.46804443549,-0.0752285585987758,NA,4692673.51081066,0.384555509373631,1,0,0,188.544222231268,0.999999999999997,"lineage3","other_mutations_pyrazinamide","THR",0,"ERR2510622","ERR2510622","lineage3","pk","Pakistan","pnca_p.ile31thr","A","H","ILE","IA31","pnca_complex.pdb"
|
|
"I31T","L2","PZA","I","I31",31,"T",NA,"MDR","OM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",11.654,-0.358,-3.12,3.06922,-3.102,-3.05,62,80,-0.562,7,7,0,0,"helix",1.83333333333333,6.99,7.18700589334483e-05,2.42412778478352,0.0001249735077034,0,1.03410070803344e-29,24,0,0,0,0,0,0,0,0,-2,0,-2,0,0,0,0,0,-5,0,-5,0,2,0,2,0,-0.0906788247213779,-0.806201550387597,0.111787673278506,-0.528900255754476,-0.798429319371728,0.652631578947368,-0.462932454695222,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.485,"8:7","147/150","I:L:V:T:A",-8.98740878149641,0.940032862253633,119.46804443549,-0.0752285585987758,NA,4692673.51081066,0.384555509373631,1,0,0,188.544222231268,0.999999999999997,"lineage2","other_mutations_pyrazinamide","THR",0,"SRR7517777","SRR7517777","lineage2.2.1","th","Thailand","pnca_p.ile31thr","A","H","ILE","IA31","pnca_complex.pdb"
|
|
"I31T","L1;L2","PZA","I","I31",31,"T",NA,"MDR","OM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",11.654,-0.358,-3.12,3.06922,-3.102,-3.05,62,80,-0.562,7,7,0,0,"helix",1.83333333333333,6.99,7.18700589334483e-05,2.42412778478352,0.0001249735077034,0,1.03410070803344e-29,24,0,0,0,0,0,0,0,0,-2,0,-2,0,0,0,0,0,-5,0,-5,0,2,0,2,0,-0.0906788247213779,-0.806201550387597,0.111787673278506,-0.528900255754476,-0.798429319371728,0.652631578947368,-0.462932454695222,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.485,"8:7","147/150","I:L:V:T:A",-8.98740878149641,0.940032862253633,119.46804443549,-0.0752285585987758,NA,4692673.51081066,0.384555509373631,1,0,0,188.544222231268,0.999999999999997,"lineage1;lineage2","other_mutations_pyrazinamide","THR",0,"SRR5709818,SAMN07236337","SRR5709818","lineage2.2.1;lineage1.2.1","th","Thailand","pnca_p.ile31thr","A","H","ILE","IA31","pnca_complex.pdb"
|
|
"I31T","L2","PZA","I","I31",31,"T",NA,"MDR","OM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",11.654,-0.358,-3.12,3.06922,-3.102,-3.05,62,80,-0.562,7,7,0,0,"helix",1.83333333333333,6.99,7.18700589334483e-05,2.42412778478352,0.0001249735077034,0,1.03410070803344e-29,24,0,0,0,0,0,0,0,0,-2,0,-2,0,0,0,0,0,-5,0,-5,0,2,0,2,0,-0.0906788247213779,-0.806201550387597,0.111787673278506,-0.528900255754476,-0.798429319371728,0.652631578947368,-0.462932454695222,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.485,"8:7","147/150","I:L:V:T:A",-8.98740878149641,0.940032862253633,119.46804443549,-0.0752285585987758,NA,4692673.51081066,0.384555509373631,1,0,0,188.544222231268,0.999999999999997,"lineage2","other_mutations_pyrazinamide","THR",0,"SAMN07236371,SRR5709775","SRR5709775","lineage2.2.1","th","Thailand","pnca_p.ile31thr","A","H","ILE","IA31","pnca_complex.pdb"
|
|
"I31T","L2","PZA","I","I31",31,"T",NA,"MDR","OM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",11.654,-0.358,-3.12,3.06922,-3.102,-3.05,62,80,-0.562,7,7,0,0,"helix",1.83333333333333,6.99,7.18700589334483e-05,2.42412778478352,0.0001249735077034,0,1.03410070803344e-29,24,0,0,0,0,0,0,0,0,-2,0,-2,0,0,0,0,0,-5,0,-5,0,2,0,2,0,-0.0906788247213779,-0.806201550387597,0.111787673278506,-0.528900255754476,-0.798429319371728,0.652631578947368,-0.462932454695222,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.485,"8:7","147/150","I:L:V:T:A",-8.98740878149641,0.940032862253633,119.46804443549,-0.0752285585987758,NA,4692673.51081066,0.384555509373631,1,0,0,188.544222231268,0.999999999999997,"lineage2","other_mutations_pyrazinamide","THR",0,"SAMN07236390,SRR5709844","SRR5709844","lineage2.2.1","th","Thailand","pnca_p.ile31thr","A","H","ILE","IA31","pnca_complex.pdb"
|
|
"I31T","L2","PZA","I","I31",31,"T",NA,"MDR","OM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",11.654,-0.358,-3.12,3.06922,-3.102,-3.05,62,80,-0.562,7,7,0,0,"helix",1.83333333333333,6.99,7.18700589334483e-05,2.42412778478352,0.0001249735077034,0,1.03410070803344e-29,24,0,0,0,0,0,0,0,0,-2,0,-2,0,0,0,0,0,-5,0,-5,0,2,0,2,0,-0.0906788247213779,-0.806201550387597,0.111787673278506,-0.528900255754476,-0.798429319371728,0.652631578947368,-0.462932454695222,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.485,"8:7","147/150","I:L:V:T:A",-8.98740878149641,0.940032862253633,119.46804443549,-0.0752285585987758,NA,4692673.51081066,0.384555509373631,1,0,0,188.544222231268,0.999999999999997,"lineage2","other_mutations_pyrazinamide","THR",0,"SAMN07236361,SRR5709961","SRR5709961","lineage2.2.1","th","Thailand","pnca_p.ile31thr","A","H","ILE","IA31","pnca_complex.pdb"
|
|
"I31T","L2","PZA","I","I31",31,"T",NA,"MDR","OM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",11.654,-0.358,-3.12,3.06922,-3.102,-3.05,62,80,-0.562,7,7,0,0,"helix",1.83333333333333,6.99,7.18700589334483e-05,2.42412778478352,0.0001249735077034,0,1.03410070803344e-29,24,0,0,0,0,0,0,0,0,-2,0,-2,0,0,0,0,0,-5,0,-5,0,2,0,2,0,-0.0906788247213779,-0.806201550387597,0.111787673278506,-0.528900255754476,-0.798429319371728,0.652631578947368,-0.462932454695222,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.485,"8:7","147/150","I:L:V:T:A",-8.98740878149641,0.940032862253633,119.46804443549,-0.0752285585987758,NA,4692673.51081066,0.384555509373631,1,0,0,188.544222231268,0.999999999999997,"lineage2","other_mutations_pyrazinamide","THR",0,"SRR5710007,SAMN07236338","SRR5710007","lineage2.2.1","th","Thailand","pnca_p.ile31thr","A","H","ILE","IA31","pnca_complex.pdb"
|
|
"I31T","L2","PZA","I","I31",31,"T",NA,"MDR","OM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",11.654,-0.358,-3.12,3.06922,-3.102,-3.05,62,80,-0.562,7,7,0,0,"helix",1.83333333333333,6.99,7.18700589334483e-05,2.42412778478352,0.0001249735077034,0,1.03410070803344e-29,24,0,0,0,0,0,0,0,0,-2,0,-2,0,0,0,0,0,-5,0,-5,0,2,0,2,0,-0.0906788247213779,-0.806201550387597,0.111787673278506,-0.528900255754476,-0.798429319371728,0.652631578947368,-0.462932454695222,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.485,"8:7","147/150","I:L:V:T:A",-8.98740878149641,0.940032862253633,119.46804443549,-0.0752285585987758,NA,4692673.51081066,0.384555509373631,1,0,0,188.544222231268,0.999999999999997,"lineage2","other_mutations_pyrazinamide","THR",0,"SRR5709879,SAMN07236399","SRR5709879","lineage2.2.1","th","Thailand","pnca_p.ile31thr","A","H","ILE","IA31","pnca_complex.pdb"
|
|
"I31T","L2","PZA","I","I31",31,"T",NA,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",11.654,-0.358,-3.12,3.06922,-3.102,-3.05,62,80,-0.562,7,7,0,0,"helix",1.83333333333333,6.99,7.18700589334483e-05,2.42412778478352,0.0001249735077034,0,1.03410070803344e-29,24,0,0,0,0,0,0,0,0,-2,0,-2,0,0,0,0,0,-5,0,-5,0,2,0,2,0,-0.0906788247213779,-0.806201550387597,0.111787673278506,-0.528900255754476,-0.798429319371728,0.652631578947368,-0.462932454695222,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.485,"8:7","147/150","I:L:V:T:A",-8.98740878149641,0.940032862253633,119.46804443549,-0.0752285585987758,NA,4692673.51081066,0.384555509373631,1,0,0,188.544222231268,0.999999999999997,"lineage2","other_mutations_pyrazinamide","THR",0,"SRR5709843,SAMN07236389","SRR5709843","lineage2.2.1","th","Thailand","pnca_p.ile31thr","A","H","ILE","IA31","pnca_complex.pdb"
|
|
"I31T","L2","PZA","I","I31",31,"T",NA,"MDR","OM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",11.654,-0.358,-3.12,3.06922,-3.102,-3.05,62,80,-0.562,7,7,0,0,"helix",1.83333333333333,6.99,7.18700589334483e-05,2.42412778478352,0.0001249735077034,0,1.03410070803344e-29,24,0,0,0,0,0,0,0,0,-2,0,-2,0,0,0,0,0,-5,0,-5,0,2,0,2,0,-0.0906788247213779,-0.806201550387597,0.111787673278506,-0.528900255754476,-0.798429319371728,0.652631578947368,-0.462932454695222,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.485,"8:7","147/150","I:L:V:T:A",-8.98740878149641,0.940032862253633,119.46804443549,-0.0752285585987758,NA,4692673.51081066,0.384555509373631,1,0,0,188.544222231268,0.999999999999997,"lineage2","other_mutations_pyrazinamide","THR",0,"SRR5709952,SAMN07236421","SRR5709952","lineage2.2.1","th","Thailand","pnca_p.ile31thr","A","H","ILE","IA31","pnca_complex.pdb"
|
|
"I31T","L2","PZA","I","I31",31,"T",NA,"MDR","OM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",11.654,-0.358,-3.12,3.06922,-3.102,-3.05,62,80,-0.562,7,7,0,0,"helix",1.83333333333333,6.99,7.18700589334483e-05,2.42412778478352,0.0001249735077034,0,1.03410070803344e-29,24,0,0,0,0,0,0,0,0,-2,0,-2,0,0,0,0,0,-5,0,-5,0,2,0,2,0,-0.0906788247213779,-0.806201550387597,0.111787673278506,-0.528900255754476,-0.798429319371728,0.652631578947368,-0.462932454695222,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.485,"8:7","147/150","I:L:V:T:A",-8.98740878149641,0.940032862253633,119.46804443549,-0.0752285585987758,NA,4692673.51081066,0.384555509373631,1,0,0,188.544222231268,0.999999999999997,"lineage2","other_mutations_pyrazinamide","THR",0,"SAMN07236378,SRR5709812","SRR5709812","lineage2.2.1","th","Thailand","pnca_p.ile31thr","A","H","ILE","IA31","pnca_complex.pdb"
|
|
"I31T","L2","PZA","I","I31",31,"T",NA,"MDR","OM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",11.654,-0.358,-3.12,3.06922,-3.102,-3.05,62,80,-0.562,7,7,0,0,"helix",1.83333333333333,6.99,7.18700589334483e-05,2.42412778478352,0.0001249735077034,0,1.03410070803344e-29,24,0,0,0,0,0,0,0,0,-2,0,-2,0,0,0,0,0,-5,0,-5,0,2,0,2,0,-0.0906788247213779,-0.806201550387597,0.111787673278506,-0.528900255754476,-0.798429319371728,0.652631578947368,-0.462932454695222,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.485,"8:7","147/150","I:L:V:T:A",-8.98740878149641,0.940032862253633,119.46804443549,-0.0752285585987758,NA,4692673.51081066,0.384555509373631,1,0,0,188.544222231268,0.999999999999997,"lineage2","other_mutations_pyrazinamide","THR",0,"SRR5709753","SRR5709753","lineage2.2.1","th","Thailand","pnca_p.ile31thr","A","H","ILE","IA31","pnca_complex.pdb"
|
|
"I31T","L2","PZA","I","I31",31,"T",NA,"MDR","OM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",11.654,-0.358,-3.12,3.06922,-3.102,-3.05,62,80,-0.562,7,7,0,0,"helix",1.83333333333333,6.99,7.18700589334483e-05,2.42412778478352,0.0001249735077034,0,1.03410070803344e-29,24,0,0,0,0,0,0,0,0,-2,0,-2,0,0,0,0,0,-5,0,-5,0,2,0,2,0,-0.0906788247213779,-0.806201550387597,0.111787673278506,-0.528900255754476,-0.798429319371728,0.652631578947368,-0.462932454695222,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.485,"8:7","147/150","I:L:V:T:A",-8.98740878149641,0.940032862253633,119.46804443549,-0.0752285585987758,NA,4692673.51081066,0.384555509373631,1,0,0,188.544222231268,0.999999999999997,"lineage2","other_mutations_pyrazinamide","THR",0,"SAMN07236377,SRR5709769","SRR5709769","lineage2.2.1","th","Thailand","pnca_p.ile31thr","A","H","ILE","IA31","pnca_complex.pdb"
|
|
"I31T","L2","PZA","I","I31",31,"T",NA,"MDR","OM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",11.654,-0.358,-3.12,3.06922,-3.102,-3.05,62,80,-0.562,7,7,0,0,"helix",1.83333333333333,6.99,7.18700589334483e-05,2.42412778478352,0.0001249735077034,0,1.03410070803344e-29,24,0,0,0,0,0,0,0,0,-2,0,-2,0,0,0,0,0,-5,0,-5,0,2,0,2,0,-0.0906788247213779,-0.806201550387597,0.111787673278506,-0.528900255754476,-0.798429319371728,0.652631578947368,-0.462932454695222,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.485,"8:7","147/150","I:L:V:T:A",-8.98740878149641,0.940032862253633,119.46804443549,-0.0752285585987758,NA,4692673.51081066,0.384555509373631,1,0,0,188.544222231268,0.999999999999997,"lineage2","other_mutations_pyrazinamide","THR",0,"SRR5709811,SAMN07236379","SRR5709811","lineage2.2.1","th","Thailand","pnca_p.ile31thr","A","H","ILE","IA31","pnca_complex.pdb"
|
|
"I31T","L2","PZA","I","I31",31,"T",NA,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",11.654,-0.358,-3.12,3.06922,-3.102,-3.05,62,80,-0.562,7,7,0,0,"helix",1.83333333333333,6.99,7.18700589334483e-05,2.42412778478352,0.0001249735077034,0,1.03410070803344e-29,24,0,0,0,0,0,0,0,0,-2,0,-2,0,0,0,0,0,-5,0,-5,0,2,0,2,0,-0.0906788247213779,-0.806201550387597,0.111787673278506,-0.528900255754476,-0.798429319371728,0.652631578947368,-0.462932454695222,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.485,"8:7","147/150","I:L:V:T:A",-8.98740878149641,0.940032862253633,119.46804443549,-0.0752285585987758,NA,4692673.51081066,0.384555509373631,1,0,0,188.544222231268,0.999999999999997,"lineage2","other_mutations_pyrazinamide","THR",0,"SRR5709867,SAMN07236322","SRR5709867","lineage2.2.1","th","Thailand","pnca_p.ile31thr","A","H","ILE","IA31","pnca_complex.pdb"
|
|
"I31T","L2","PZA","I","I31",31,"T",NA,"MDR","OM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",11.654,-0.358,-3.12,3.06922,-3.102,-3.05,62,80,-0.562,7,7,0,0,"helix",1.83333333333333,6.99,7.18700589334483e-05,2.42412778478352,0.0001249735077034,0,1.03410070803344e-29,24,0,0,0,0,0,0,0,0,-2,0,-2,0,0,0,0,0,-5,0,-5,0,2,0,2,0,-0.0906788247213779,-0.806201550387597,0.111787673278506,-0.528900255754476,-0.798429319371728,0.652631578947368,-0.462932454695222,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.485,"8:7","147/150","I:L:V:T:A",-8.98740878149641,0.940032862253633,119.46804443549,-0.0752285585987758,NA,4692673.51081066,0.384555509373631,1,0,0,188.544222231268,0.999999999999997,"lineage2","other_mutations_pyrazinamide","THR",0,"SAMN07236383,SRR5709807","SRR5709807","lineage2.2.1","th","Thailand","pnca_p.ile31thr","A","H","ILE","IA31","pnca_complex.pdb"
|
|
"I31T","L2","PZA","I","I31",31,"T",NA,"MDR","OM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",11.654,-0.358,-3.12,3.06922,-3.102,-3.05,62,80,-0.562,7,7,0,0,"helix",1.83333333333333,6.99,7.18700589334483e-05,2.42412778478352,0.0001249735077034,0,1.03410070803344e-29,24,0,0,0,0,0,0,0,0,-2,0,-2,0,0,0,0,0,-5,0,-5,0,2,0,2,0,-0.0906788247213779,-0.806201550387597,0.111787673278506,-0.528900255754476,-0.798429319371728,0.652631578947368,-0.462932454695222,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.485,"8:7","147/150","I:L:V:T:A",-8.98740878149641,0.940032862253633,119.46804443549,-0.0752285585987758,NA,4692673.51081066,0.384555509373631,1,0,0,188.544222231268,0.999999999999997,"lineage2","other_mutations_pyrazinamide","THR",0,"SAMN07236385,SRR5709809","SRR5709809","lineage2.2.1","th","Thailand","pnca_p.ile31thr","A","H","ILE","IA31","pnca_complex.pdb"
|
|
"I31T","L2","PZA","I","I31",31,"T",NA,"MDR","OM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",11.654,-0.358,-3.12,3.06922,-3.102,-3.05,62,80,-0.562,7,7,0,0,"helix",1.83333333333333,6.99,7.18700589334483e-05,2.42412778478352,0.0001249735077034,0,1.03410070803344e-29,24,0,0,0,0,0,0,0,0,-2,0,-2,0,0,0,0,0,-5,0,-5,0,2,0,2,0,-0.0906788247213779,-0.806201550387597,0.111787673278506,-0.528900255754476,-0.798429319371728,0.652631578947368,-0.462932454695222,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.485,"8:7","147/150","I:L:V:T:A",-8.98740878149641,0.940032862253633,119.46804443549,-0.0752285585987758,NA,4692673.51081066,0.384555509373631,1,0,0,188.544222231268,0.999999999999997,"lineage2","other_mutations_pyrazinamide","THR",0,"SAMN07360951,SRR5837706","SRR5837706","lineage2.2.1","th","Thailand","pnca_p.ile31thr","A","H","ILE","IA31","pnca_complex.pdb"
|
|
"S32G","L1","PZA","S","S32",32,"G",NA,"Sensitive","OM","hydrophilic","hydrophobic","neutral","neutral","polar","non-polar",16.787,-1.334,-0.875,0.0485615999999999,-0.992,-0.43,-32,66,-0.647,7,7,7,0.0451612903225806,"loop",0.0666666666666666,4.62,NA,NA,NA,NA,NA,4,0,0,0,0,0,0,0,0,2,0,4,0,0,0,0,0,3,0,3,0,2,0,5,17,-0.337892603850051,-0.22609819121447,0.00176871917773293,-0.169138959931799,-0.112565445026178,-0.344086021505376,-0.532948929159802,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","neutral",-0.779,-0.553,"8:7","147/150","D:T:S:G:A:V:N:R:Q",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage1","other_mutations_pyrazinamide","GLY",0,"SRR5067283","SRR5067283","lineage1.1.1","vn","Vietnam","pnca_p.ser32gly","A","T","SER","SA32","pnca_complex.pdb"
|
|
"S32I","L4","PZA","S","S32",32,"I",1,"Pre-XDR","DM","hydrophilic","hydrophobic","neutral","non-polar","polar","non-polar",16.787,-1.207,0.018,0.86851,-0.677,-0.41,29,63,-0.647,7,7,7,0.0451612903225806,"loop",0.0666666666666666,4.62,7.18700589334483e-05,9.70142977291842,188179.926264664,Inf,0.763784339928386,-10,0,0,0,0,0,0,0,0,2,0,4,0,0,0,0,0,0,0,-2,-3,0,0,0,0,-0.305724417426545,0.0153061224489795,0.0316330247160891,-0.115430520034101,-0.107329842931937,0.305263157894737,-0.532948929159802,"Destabilising","Stabilising","Destabilising","Destabilising","Destabilising","effect",-0.779,-0.553,"8:7","147/150","D:T:S:G:A:V:N:R:Q",12.1451538387266,0.919026337424239,119.468044436241,0.101660271548249,5.01153666061844e-06,NA,0.986835744238421,0.170978870202674,0.767057556984365,0.124324963210678,Inf,0.382146811758261,"lineage4","dr_mutations_pyrazinamide","ILE",0,"ERS458092","ERR552499_ERR552498","lineage4.3.3","uz","Nukus","pnca_p.ser32ile","A","T","SER","SA32","pnca_complex.pdb"
|
|
"S32I","L4","PZA","S","S32",32,"I",NA,"Pre-XDR","DM","hydrophilic","hydrophobic","neutral","non-polar","polar","non-polar",16.787,-1.207,0.018,0.86851,-0.677,-0.41,29,63,-0.647,7,7,7,0.0451612903225806,"loop",0.0666666666666666,4.62,7.18700589334483e-05,9.70142977291842,188179.926264664,Inf,0.763784339928386,-10,0,0,0,0,0,0,0,0,2,0,4,0,0,0,0,0,0,0,-2,-3,0,0,0,0,-0.305724417426545,0.0153061224489795,0.0316330247160891,-0.115430520034101,-0.107329842931937,0.305263157894737,-0.532948929159802,"Destabilising","Stabilising","Destabilising","Destabilising","Destabilising","effect",-0.779,-0.553,"8:7","147/150","D:T:S:G:A:V:N:R:Q",12.1451538387266,0.919026337424239,119.468044436241,0.101660271548249,5.01153666061844e-06,NA,0.986835744238421,0.170978870202674,0.767057556984365,0.124324963210678,Inf,0.382146811758261,"lineage4","dr_mutations_pyrazinamide","ILE",0,"ERR1193903","ERR1193903","lineage4.3.3","uz","Uzbekistan","pnca_p.ser32ile","A","T","SER","SA32","pnca_complex.pdb"
|
|
"D33V","L4","PZA","D","D33",33,"V",1,"Other","OM","hydrophilic","hydrophobic","acidic","non-polar","neg","non-polar",20.313,-0.795,0.276,1.48114,-0.022,-0.3,-5,53,1.213,1,1,77,0.398963730569948,"loop",-1.86666666666667,3.72,7.18700589334483e-05,9.70142977291842,188179.9262646,Inf,0.763784339928386,4,14,0,2,12,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-2,-0.201367781155015,0.23469387755102,0.053946342849234,-0.00375106564364876,-0.0785340314136125,-0.0537634408602151,0.388782051282051,"Destabilising","Stabilising","Destabilising","Destabilising","Destabilising","neutral",0.842,1.183,"2:1","147/150","N:L:V:K:R:H:E:Q:D:T:A:S:G",12.1451538387263,0.919026337424228,119.468044436221,0.101660271548264,5.01153666063734e-06,NA,0.986835744238421,0.170978870202674,0.767057556984365,0.124324963210678,Inf,0.382146811758261,"lineage4","other_mutations_pyrazinamide","VAL",0,"ERS457272","ERR551343_ERR551342","lineage4.1.2.1","uz","Nukus","pnca_p.asp33val","A","T","ASP","DA33","pnca_complex.pdb"
|
|
"Y34C","L4","PZA","Y","Y34",34,"C",NA,"MDR","OM","hydrophobic","hydrophobic","neutral","neutral","polar","non-polar",18.259,-0.635,-1.829,1.92562,-0.861,-1.94,-2,53,0.42,3,3,26,0.0988593155893536,"loop",-0.333333333333333,4.65,NA,NA,NA,NA,NA,48,10,0,2,8,0,0,0,0,-2,0,-4,2,0,0,0,0,2,0,0,2,6,0,2,6,-0.160840932117528,-0.472609819121447,0.0701352719643937,-0.146803069053708,-0.507853403141361,-0.021505376344086,0.134615384615385,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","neutral",0.083,0.59,"5:3","147/150","M:A:W:Y:E:F:H:Q:V:L:R:C:I",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage4","other_mutations_pyrazinamide","CYS",0,"SAMN02231172","SRR998793_SRR998792_SRR998795_SRR998794","lineage4.1","ml","Mali","pnca_p.tyr34cys","A","T","TYR","YA34","pnca_complex.pdb"
|
|
"Y34C","L4","PZA","Y","Y34",34,"C",NA,"MDR","OM","hydrophobic","hydrophobic","neutral","neutral","polar","non-polar",18.259,-0.635,-1.829,1.92562,-0.861,-1.94,-2,53,0.42,3,3,26,0.0988593155893536,"loop",-0.333333333333333,4.65,NA,NA,NA,NA,NA,48,10,0,2,8,0,0,0,0,-2,0,-4,2,0,0,0,0,2,0,0,2,6,0,2,6,-0.160840932117528,-0.472609819121447,0.0701352719643937,-0.146803069053708,-0.507853403141361,-0.021505376344086,0.134615384615385,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","neutral",0.083,0.59,"5:3","147/150","M:A:W:Y:E:F:H:Q:V:L:R:C:I",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage4","other_mutations_pyrazinamide","CYS",0,"ERR2679268","ERR2679268","lineage4.1","","","pnca_p.tyr34cys","A","T","TYR","YA34","pnca_complex.pdb"
|
|
"Y34D","L4","PZA","Y","Y34",34,"D",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","neutral","acidic","polar","neg",18.259,0.124,-1.857,2.0881,-1.484,-1.99,30,66,0.42,3,3,26,0.0988593155893536,"loop",-0.333333333333333,4.65,0.0005749604714675,14.5802781289507,14.5802277940117,14.5801759034061,15.0663448164144,38,-18,0,0,-18,0,0,0,0,2,0,0,2,0,0,0,0,3,0,0,3,8,0,2,6,0.0556053811659192,-0.47984496124031,0.0760531472402917,-0.253026427962489,-0.520942408376963,0.315789473684211,0.134615384615385,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.083,0.59,"5:3","147/150","M:A:W:Y:E:F:H:Q:V:L:R:C:I",2.6796663501904,0.0010245352377104,0.816050632122416,3.28370108999367,3.35697961122125,99.553869259241,1.16376580853041,0.0005075351447614,3.29453387923245,2.60435121163486,147.676327006136,0.0001037975122989,"lineage4","dr_mutations_pyrazinamide","ASP",0,"SAMN02350491","SRR1019165_SRR1140957","lineage4.4.1.1","za","South Africa","pnca_p.tyr34asp","A","T","TYR","YA34","pnca_complex.pdb"
|
|
"Y34D","L4","PZA","Y","Y34",34,"D",NA,"MDR","DM","hydrophobic","hydrophilic","neutral","acidic","polar","neg",18.259,0.124,-1.857,2.0881,-1.484,-1.99,30,66,0.42,3,3,26,0.0988593155893536,"loop",-0.333333333333333,4.65,0.0005749604714675,14.5802781289507,14.5802277940117,14.5801759034061,15.0663448164144,38,-18,0,0,-18,0,0,0,0,2,0,0,2,0,0,0,0,3,0,0,3,8,0,2,6,0.0556053811659192,-0.47984496124031,0.0760531472402917,-0.253026427962489,-0.520942408376963,0.315789473684211,0.134615384615385,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.083,0.59,"5:3","147/150","M:A:W:Y:E:F:H:Q:V:L:R:C:I",2.6796663501904,0.0010245352377104,0.816050632122416,3.28370108999367,3.35697961122125,99.553869259241,1.16376580853041,0.0005075351447614,3.29453387923245,2.60435121163486,147.676327006136,0.0001037975122989,"lineage4","dr_mutations_pyrazinamide","ASP",0,"SAMN02403524","SRR1167287_SRR1173364_SRR1173333_SRR1165237","lineage4.4.1.1","za","South Africa","pnca_p.tyr34asp","A","T","TYR","YA34","pnca_complex.pdb"
|
|
"Y34D","L4","PZA","Y","Y34",34,"D",NA,"MDR","DM","hydrophobic","hydrophilic","neutral","acidic","polar","neg",18.259,0.124,-1.857,2.0881,-1.484,-1.99,30,66,0.42,3,3,26,0.0988593155893536,"loop",-0.333333333333333,4.65,0.0005749604714675,14.5802781289507,14.5802277940117,14.5801759034061,15.0663448164144,38,-18,0,0,-18,0,0,0,0,2,0,0,2,0,0,0,0,3,0,0,3,8,0,2,6,0.0556053811659192,-0.47984496124031,0.0760531472402917,-0.253026427962489,-0.520942408376963,0.315789473684211,0.134615384615385,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.083,0.59,"5:3","147/150","M:A:W:Y:E:F:H:Q:V:L:R:C:I",2.6796663501904,0.0010245352377104,0.816050632122416,3.28370108999367,3.35697961122125,99.553869259241,1.16376580853041,0.0005075351447614,3.29453387923245,2.60435121163486,147.676327006136,0.0001037975122989,"lineage4","dr_mutations_pyrazinamide","ASP",0,"SAMN02403563","SRR1167334_SRR1169307_SRR1165623_SRR1169222","lineage4.4.1.1","za","South Africa","pnca_p.tyr34asp","A","T","TYR","YA34","pnca_complex.pdb"
|
|
"Y34D","L4","PZA","Y","Y34",34,"D",NA,"MDR","DM","hydrophobic","hydrophilic","neutral","acidic","polar","neg",18.259,0.124,-1.857,2.0881,-1.484,-1.99,30,66,0.42,3,3,26,0.0988593155893536,"loop",-0.333333333333333,4.65,0.0005749604714675,14.5802781289507,14.5802277940117,14.5801759034061,15.0663448164144,38,-18,0,0,-18,0,0,0,0,2,0,0,2,0,0,0,0,3,0,0,3,8,0,2,6,0.0556053811659192,-0.47984496124031,0.0760531472402917,-0.253026427962489,-0.520942408376963,0.315789473684211,0.134615384615385,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.083,0.59,"5:3","147/150","M:A:W:Y:E:F:H:Q:V:L:R:C:I",2.6796663501904,0.0010245352377104,0.816050632122416,3.28370108999367,3.35697961122125,99.553869259241,1.16376580853041,0.0005075351447614,3.29453387923245,2.60435121163486,147.676327006136,0.0001037975122989,"lineage4","dr_mutations_pyrazinamide","ASP",0,"SAMN02403548","SRR1172233_SRR1167357_SRR1169199_SRR1165648","lineage4.4.1.1","za","South Africa","pnca_p.tyr34asp","A","T","TYR","YA34","pnca_complex.pdb"
|
|
"Y34D","L4","PZA","Y","Y34",34,"D",NA,"MDR","DM","hydrophobic","hydrophilic","neutral","acidic","polar","neg",18.259,0.124,-1.857,2.0881,-1.484,-1.99,30,66,0.42,3,3,26,0.0988593155893536,"loop",-0.333333333333333,4.65,0.0005749604714675,14.5802781289507,14.5802277940117,14.5801759034061,15.0663448164144,38,-18,0,0,-18,0,0,0,0,2,0,0,2,0,0,0,0,3,0,0,3,8,0,2,6,0.0556053811659192,-0.47984496124031,0.0760531472402917,-0.253026427962489,-0.520942408376963,0.315789473684211,0.134615384615385,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.083,0.59,"5:3","147/150","M:A:W:Y:E:F:H:Q:V:L:R:C:I",2.6796663501904,0.0010245352377104,0.816050632122416,3.28370108999367,3.35697961122125,99.553869259241,1.16376580853041,0.0005075351447614,3.29453387923245,2.60435121163486,147.676327006136,0.0001037975122989,"lineage4","dr_mutations_pyrazinamide","ASP",0,"SAMN02053797","SRR833134_SRR833135","lineage4.4.1.1","za","South Africa","pnca_p.tyr34asp","A","T","TYR","YA34","pnca_complex.pdb"
|
|
"Y34D","L4","PZA","Y","Y34",34,"D",NA,"MDR","DM","hydrophobic","hydrophilic","neutral","acidic","polar","neg",18.259,0.124,-1.857,2.0881,-1.484,-1.99,30,66,0.42,3,3,26,0.0988593155893536,"loop",-0.333333333333333,4.65,0.0005749604714675,14.5802781289507,14.5802277940117,14.5801759034061,15.0663448164144,38,-18,0,0,-18,0,0,0,0,2,0,0,2,0,0,0,0,3,0,0,3,8,0,2,6,0.0556053811659192,-0.47984496124031,0.0760531472402917,-0.253026427962489,-0.520942408376963,0.315789473684211,0.134615384615385,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.083,0.59,"5:3","147/150","M:A:W:Y:E:F:H:Q:V:L:R:C:I",2.6796663501904,0.0010245352377104,0.816050632122416,3.28370108999367,3.35697961122125,99.553869259241,1.16376580853041,0.0005075351447614,3.29453387923245,2.60435121163486,147.676327006136,0.0001037975122989,"lineage4","dr_mutations_pyrazinamide","ASP",0,"SAMN02586015","SRR1173102_SRR1175041_SRR1196785_SRR1184354","lineage4.4.1.1","za","South Africa","pnca_p.tyr34asp","A","T","TYR","YA34","pnca_complex.pdb"
|
|
"Y34D","L4","PZA","Y","Y34",34,"D",NA,"MDR","DM","hydrophobic","hydrophilic","neutral","acidic","polar","neg",18.259,0.124,-1.857,2.0881,-1.484,-1.99,30,66,0.42,3,3,26,0.0988593155893536,"loop",-0.333333333333333,4.65,0.0005749604714675,14.5802781289507,14.5802277940117,14.5801759034061,15.0663448164144,38,-18,0,0,-18,0,0,0,0,2,0,0,2,0,0,0,0,3,0,0,3,8,0,2,6,0.0556053811659192,-0.47984496124031,0.0760531472402917,-0.253026427962489,-0.520942408376963,0.315789473684211,0.134615384615385,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.083,0.59,"5:3","147/150","M:A:W:Y:E:F:H:Q:V:L:R:C:I",2.6796663501904,0.0010245352377104,0.816050632122416,3.28370108999367,3.35697961122125,99.553869259241,1.16376580853041,0.0005075351447614,3.29453387923245,2.60435121163486,147.676327006136,0.0001037975122989,"lineage4","dr_mutations_pyrazinamide","ASP",0,"SAMN02403519","SRR1173145_SRR1175347_SRR1167312_SRR1165250","lineage4.4.1.1","za","South Africa","pnca_p.tyr34asp","A","T","TYR","YA34","pnca_complex.pdb"
|
|
"Y34D","L4","PZA","Y","Y34",34,"D",NA,"MDR","DM","hydrophobic","hydrophilic","neutral","acidic","polar","neg",18.259,0.124,-1.857,2.0881,-1.484,-1.99,30,66,0.42,3,3,26,0.0988593155893536,"loop",-0.333333333333333,4.65,0.0005749604714675,14.5802781289507,14.5802277940117,14.5801759034061,15.0663448164144,38,-18,0,0,-18,0,0,0,0,2,0,0,2,0,0,0,0,3,0,0,3,8,0,2,6,0.0556053811659192,-0.47984496124031,0.0760531472402917,-0.253026427962489,-0.520942408376963,0.315789473684211,0.134615384615385,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.083,0.59,"5:3","147/150","M:A:W:Y:E:F:H:Q:V:L:R:C:I",2.6796663501904,0.0010245352377104,0.816050632122416,3.28370108999367,3.35697961122125,99.553869259241,1.16376580853041,0.0005075351447614,3.29453387923245,2.60435121163486,147.676327006136,0.0001037975122989,"lineage4","dr_mutations_pyrazinamide","ASP",0,"SAMN02403502","SRR1173607_SRR1173226_SRR1165305_SRR1167272","lineage4.4.1.1","za","South Africa","pnca_p.tyr34asp","A","T","TYR","YA34","pnca_complex.pdb"
|
|
"Y34D","L4","PZA","Y","Y34",34,"D",NA,"MDR","DM","hydrophobic","hydrophilic","neutral","acidic","polar","neg",18.259,0.124,-1.857,2.0881,-1.484,-1.99,30,66,0.42,3,3,26,0.0988593155893536,"loop",-0.333333333333333,4.65,0.0005749604714675,14.5802781289507,14.5802277940117,14.5801759034061,15.0663448164144,38,-18,0,0,-18,0,0,0,0,2,0,0,2,0,0,0,0,3,0,0,3,8,0,2,6,0.0556053811659192,-0.47984496124031,0.0760531472402917,-0.253026427962489,-0.520942408376963,0.315789473684211,0.134615384615385,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.083,0.59,"5:3","147/150","M:A:W:Y:E:F:H:Q:V:L:R:C:I",2.6796663501904,0.0010245352377104,0.816050632122416,3.28370108999367,3.35697961122125,99.553869259241,1.16376580853041,0.0005075351447614,3.29453387923245,2.60435121163486,147.676327006136,0.0001037975122989,"lineage4","dr_mutations_pyrazinamide","ASP",0,"SAMN02403507","SRR1173212_SRR1165268_SRR1167292_SRR1173397","lineage4.4.1.1","za","South Africa","pnca_p.tyr34asp","A","T","TYR","YA34","pnca_complex.pdb"
|
|
"Y34D","L4","PZA","Y","Y34",34,"D",NA,"MDR","DM","hydrophobic","hydrophilic","neutral","acidic","polar","neg",18.259,0.124,-1.857,2.0881,-1.484,-1.99,30,66,0.42,3,3,26,0.0988593155893536,"loop",-0.333333333333333,4.65,0.0005749604714675,14.5802781289507,14.5802277940117,14.5801759034061,15.0663448164144,38,-18,0,0,-18,0,0,0,0,2,0,0,2,0,0,0,0,3,0,0,3,8,0,2,6,0.0556053811659192,-0.47984496124031,0.0760531472402917,-0.253026427962489,-0.520942408376963,0.315789473684211,0.134615384615385,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.083,0.59,"5:3","147/150","M:A:W:Y:E:F:H:Q:V:L:R:C:I",2.6796663501904,0.0010245352377104,0.816050632122416,3.28370108999367,3.35697961122125,99.553869259241,1.16376580853041,0.0005075351447614,3.29453387923245,2.60435121163486,147.676327006136,0.0001037975122989,"lineage4","dr_mutations_pyrazinamide","ASP",0,"SAMN02403466","SRR1175337_SRR1173154_SRR1165211_SRR1167293","lineage4.4.1.1","za","South Africa","pnca_p.tyr34asp","A","T","TYR","YA34","pnca_complex.pdb"
|
|
"Y34D","L4","PZA","Y","Y34",34,"D",NA,"MDR","DM","hydrophobic","hydrophilic","neutral","acidic","polar","neg",18.259,0.124,-1.857,2.0881,-1.484,-1.99,30,66,0.42,3,3,26,0.0988593155893536,"loop",-0.333333333333333,4.65,0.0005749604714675,14.5802781289507,14.5802277940117,14.5801759034061,15.0663448164144,38,-18,0,0,-18,0,0,0,0,2,0,0,2,0,0,0,0,3,0,0,3,8,0,2,6,0.0556053811659192,-0.47984496124031,0.0760531472402917,-0.253026427962489,-0.520942408376963,0.315789473684211,0.134615384615385,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.083,0.59,"5:3","147/150","M:A:W:Y:E:F:H:Q:V:L:R:C:I",2.6796663501904,0.0010245352377104,0.816050632122416,3.28370108999367,3.35697961122125,99.553869259241,1.16376580853041,0.0005075351447614,3.29453387923245,2.60435121163486,147.676327006136,0.0001037975122989,"lineage4","dr_mutations_pyrazinamide","ASP",0,"SAMN02403503","SRR1173300_SRR1165249_SRR1173855_SRR1167251","lineage4.4.1.1","za","South Africa","pnca_p.tyr34asp","A","T","TYR","YA34","pnca_complex.pdb"
|
|
"Y34D","L4","PZA","Y","Y34",34,"D",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","neutral","acidic","polar","neg",18.259,0.124,-1.857,2.0881,-1.484,-1.99,30,66,0.42,3,3,26,0.0988593155893536,"loop",-0.333333333333333,4.65,0.0005749604714675,14.5802781289507,14.5802277940117,14.5801759034061,15.0663448164144,38,-18,0,0,-18,0,0,0,0,2,0,0,2,0,0,0,0,3,0,0,3,8,0,2,6,0.0556053811659192,-0.47984496124031,0.0760531472402917,-0.253026427962489,-0.520942408376963,0.315789473684211,0.134615384615385,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.083,0.59,"5:3","147/150","M:A:W:Y:E:F:H:Q:V:L:R:C:I",2.6796663501904,0.0010245352377104,0.816050632122416,3.28370108999367,3.35697961122125,99.553869259241,1.16376580853041,0.0005075351447614,3.29453387923245,2.60435121163486,147.676327006136,0.0001037975122989,"lineage4","dr_mutations_pyrazinamide","ASP",0,"SAMN02585990","SRR1196569_SRR1173320_SRR1173181_SRR1184353","lineage4.4.1.1","za","South Africa","pnca_p.tyr34asp","A","T","TYR","YA34","pnca_complex.pdb"
|
|
"Y34D","L4","PZA","Y","Y34",34,"D",NA,"MDR","DM","hydrophobic","hydrophilic","neutral","acidic","polar","neg",18.259,0.124,-1.857,2.0881,-1.484,-1.99,30,66,0.42,3,3,26,0.0988593155893536,"loop",-0.333333333333333,4.65,0.0005749604714675,14.5802781289507,14.5802277940117,14.5801759034061,15.0663448164144,38,-18,0,0,-18,0,0,0,0,2,0,0,2,0,0,0,0,3,0,0,3,8,0,2,6,0.0556053811659192,-0.47984496124031,0.0760531472402917,-0.253026427962489,-0.520942408376963,0.315789473684211,0.134615384615385,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.083,0.59,"5:3","147/150","M:A:W:Y:E:F:H:Q:V:L:R:C:I",2.6796663501904,0.0010245352377104,0.816050632122416,3.28370108999367,3.35697961122125,99.553869259241,1.16376580853041,0.0005075351447614,3.29453387923245,2.60435121163486,147.676327006136,0.0001037975122989,"lineage4","dr_mutations_pyrazinamide","ASP",0,"SAMN02586023","SRR1175305_SRR1172876","lineage4.4.1.1","za","South Africa","pnca_p.tyr34asp","A","T","TYR","YA34","pnca_complex.pdb"
|
|
"Y34D","L1","PZA","Y","Y34",34,"D",1,"MDR","DM","hydrophobic","hydrophilic","neutral","acidic","polar","neg",18.259,0.124,-1.857,2.0881,-1.484,-1.99,30,66,0.42,3,3,26,0.0988593155893536,"loop",-0.333333333333333,4.65,0.0005749604714675,14.5802781289507,14.5802277940117,14.5801759034061,15.0663448164144,38,-18,0,0,-18,0,0,0,0,2,0,0,2,0,0,0,0,3,0,0,3,8,0,2,6,0.0556053811659192,-0.47984496124031,0.0760531472402917,-0.253026427962489,-0.520942408376963,0.315789473684211,0.134615384615385,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.083,0.59,"5:3","147/150","M:A:W:Y:E:F:H:Q:V:L:R:C:I",2.6796663501904,0.0010245352377104,0.816050632122416,3.28370108999367,3.35697961122125,99.553869259241,1.16376580853041,0.0005075351447614,3.29453387923245,2.60435121163486,147.676327006136,0.0001037975122989,"lineage1","dr_mutations_pyrazinamide","ASP",0,"ERR2510649","ERR2510649","lineage1.1.2","pk","Pakistan","pnca_p.tyr34asp","A","T","TYR","YA34","pnca_complex.pdb"
|
|
"Y34D","L4","PZA","Y","Y34",34,"D",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","neutral","acidic","polar","neg",18.259,0.124,-1.857,2.0881,-1.484,-1.99,30,66,0.42,3,3,26,0.0988593155893536,"loop",-0.333333333333333,4.65,0.0005749604714675,14.5802781289507,14.5802277940117,14.5801759034061,15.0663448164144,38,-18,0,0,-18,0,0,0,0,2,0,0,2,0,0,0,0,3,0,0,3,8,0,2,6,0.0556053811659192,-0.47984496124031,0.0760531472402917,-0.253026427962489,-0.520942408376963,0.315789473684211,0.134615384615385,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.083,0.59,"5:3","147/150","M:A:W:Y:E:F:H:Q:V:L:R:C:I",2.6796663501904,0.0010245352377104,0.816050632122416,3.28370108999367,3.35697961122125,99.553869259241,1.16376580853041,0.0005075351447614,3.29453387923245,2.60435121163486,147.676327006136,0.0001037975122989,"lineage4","dr_mutations_pyrazinamide","ASP",0,"SAMN02586025","SRR1173270_SRR1196528_SRR1173195_SRR1184352","lineage4.4.1.1","za","South Africa","pnca_p.tyr34asp","A","T","TYR","YA34","pnca_complex.pdb"
|
|
"Y34D","L4","PZA","Y","Y34",34,"D",NA,"MDR","DM","hydrophobic","hydrophilic","neutral","acidic","polar","neg",18.259,0.124,-1.857,2.0881,-1.484,-1.99,30,66,0.42,3,3,26,0.0988593155893536,"loop",-0.333333333333333,4.65,0.0005749604714675,14.5802781289507,14.5802277940117,14.5801759034061,15.0663448164144,38,-18,0,0,-18,0,0,0,0,2,0,0,2,0,0,0,0,3,0,0,3,8,0,2,6,0.0556053811659192,-0.47984496124031,0.0760531472402917,-0.253026427962489,-0.520942408376963,0.315789473684211,0.134615384615385,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.083,0.59,"5:3","147/150","M:A:W:Y:E:F:H:Q:V:L:R:C:I",2.6796663501904,0.0010245352377104,0.816050632122416,3.28370108999367,3.35697961122125,99.553869259241,1.16376580853041,0.0005075351447614,3.29453387923245,2.60435121163486,147.676327006136,0.0001037975122989,"lineage4","dr_mutations_pyrazinamide","ASP",0,"SAMN02053790","SRR833148_SRR832988_SRR833042","lineage4.4.1.1","za","South Africa","pnca_p.tyr34asp","A","T","TYR","YA34","pnca_complex.pdb"
|
|
"Y34D","L4","PZA","Y","Y34",34,"D",NA,"MDR","DM","hydrophobic","hydrophilic","neutral","acidic","polar","neg",18.259,0.124,-1.857,2.0881,-1.484,-1.99,30,66,0.42,3,3,26,0.0988593155893536,"loop",-0.333333333333333,4.65,0.0005749604714675,14.5802781289507,14.5802277940117,14.5801759034061,15.0663448164144,38,-18,0,0,-18,0,0,0,0,2,0,0,2,0,0,0,0,3,0,0,3,8,0,2,6,0.0556053811659192,-0.47984496124031,0.0760531472402917,-0.253026427962489,-0.520942408376963,0.315789473684211,0.134615384615385,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.083,0.59,"5:3","147/150","M:A:W:Y:E:F:H:Q:V:L:R:C:I",2.6796663501904,0.0010245352377104,0.816050632122416,3.28370108999367,3.35697961122125,99.553869259241,1.16376580853041,0.0005075351447614,3.29453387923245,2.60435121163486,147.676327006136,0.0001037975122989,"lineage4","dr_mutations_pyrazinamide","ASP",0,"SAMN01925676","SRR924236_SRR847795","lineage4.4.1.1","za","South Africa","pnca_p.tyr34asp","A","T","TYR","YA34","pnca_complex.pdb"
|
|
"Y34D","L4","PZA","Y","Y34",34,"D",1,"MDR","DM","hydrophobic","hydrophilic","neutral","acidic","polar","neg",18.259,0.124,-1.857,2.0881,-1.484,-1.99,30,66,0.42,3,3,26,0.0988593155893536,"loop",-0.333333333333333,4.65,0.0005749604714675,14.5802781289507,14.5802277940117,14.5801759034061,15.0663448164144,38,-18,0,0,-18,0,0,0,0,2,0,0,2,0,0,0,0,3,0,0,3,8,0,2,6,0.0556053811659192,-0.47984496124031,0.0760531472402917,-0.253026427962489,-0.520942408376963,0.315789473684211,0.134615384615385,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.083,0.59,"5:3","147/150","M:A:W:Y:E:F:H:Q:V:L:R:C:I",2.6796663501904,0.0010245352377104,0.816050632122416,3.28370108999367,3.35697961122125,99.553869259241,1.16376580853041,0.0005075351447614,3.29453387923245,2.60435121163486,147.676327006136,0.0001037975122989,"lineage4","dr_mutations_pyrazinamide","ASP",0,"ERR2516047","ERR2516047","lineage4.4.1.1","za","South Africa","pnca_p.tyr34asp","A","T","TYR","YA34","pnca_complex.pdb"
|
|
"Y34D","L2","PZA","Y","Y34",34,"D",NA,"MDR","DM","hydrophobic","hydrophilic","neutral","acidic","polar","neg",18.259,0.124,-1.857,2.0881,-1.484,-1.99,30,66,0.42,3,3,26,0.0988593155893536,"loop",-0.333333333333333,4.65,0.0005749604714675,14.5802781289507,14.5802277940117,14.5801759034061,15.0663448164144,38,-18,0,0,-18,0,0,0,0,2,0,0,2,0,0,0,0,3,0,0,3,8,0,2,6,0.0556053811659192,-0.47984496124031,0.0760531472402917,-0.253026427962489,-0.520942408376963,0.315789473684211,0.134615384615385,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.083,0.59,"5:3","147/150","M:A:W:Y:E:F:H:Q:V:L:R:C:I",2.6796663501904,0.0010245352377104,0.816050632122416,3.28370108999367,3.35697961122125,99.553869259241,1.16376580853041,0.0005075351447614,3.29453387923245,2.60435121163486,147.676327006136,0.0001037975122989,"lineage2","dr_mutations_pyrazinamide","ASP",0,"SRR5065407","SRR5065407","lineage2.2.1","vn","Vietnam","pnca_p.tyr34asp","A","T","TYR","YA34","pnca_complex.pdb"
|
|
"Y34D","L4","PZA","Y","Y34",34,"D",NA,"MDR","DM","hydrophobic","hydrophilic","neutral","acidic","polar","neg",18.259,0.124,-1.857,2.0881,-1.484,-1.99,30,66,0.42,3,3,26,0.0988593155893536,"loop",-0.333333333333333,4.65,0.0005749604714675,14.5802781289507,14.5802277940117,14.5801759034061,15.0663448164144,38,-18,0,0,-18,0,0,0,0,2,0,0,2,0,0,0,0,3,0,0,3,8,0,2,6,0.0556053811659192,-0.47984496124031,0.0760531472402917,-0.253026427962489,-0.520942408376963,0.315789473684211,0.134615384615385,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.083,0.59,"5:3","147/150","M:A:W:Y:E:F:H:Q:V:L:R:C:I",2.6796663501904,0.0010245352377104,0.816050632122416,3.28370108999367,3.35697961122125,99.553869259241,1.16376580853041,0.0005075351447614,3.29453387923245,2.60435121163486,147.676327006136,0.0001037975122989,"lineage4","dr_mutations_pyrazinamide","ASP",0,"SAMN02403564","SRR1165619_SRR1167363_SRR1169162_SRR1174832","lineage4.4.1.1","za","South Africa","pnca_p.tyr34asp","A","T","TYR","YA34","pnca_complex.pdb"
|
|
"Y34D","L4","PZA","Y","Y34",34,"D",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","neutral","acidic","polar","neg",18.259,0.124,-1.857,2.0881,-1.484,-1.99,30,66,0.42,3,3,26,0.0988593155893536,"loop",-0.333333333333333,4.65,0.0005749604714675,14.5802781289507,14.5802277940117,14.5801759034061,15.0663448164144,38,-18,0,0,-18,0,0,0,0,2,0,0,2,0,0,0,0,3,0,0,3,8,0,2,6,0.0556053811659192,-0.47984496124031,0.0760531472402917,-0.253026427962489,-0.520942408376963,0.315789473684211,0.134615384615385,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.083,0.59,"5:3","147/150","M:A:W:Y:E:F:H:Q:V:L:R:C:I",2.6796663501904,0.0010245352377104,0.816050632122416,3.28370108999367,3.35697961122125,99.553869259241,1.16376580853041,0.0005075351447614,3.29453387923245,2.60435121163486,147.676327006136,0.0001037975122989,"lineage4","dr_mutations_pyrazinamide","ASP",0,"SAMN02350480","SRR1019142_SRR1140941","lineage4.4.1.1","za","South Africa","pnca_p.tyr34asp","A","T","TYR","YA34","pnca_complex.pdb"
|
|
"Y34D","L4","PZA","Y","Y34",34,"D",NA,"MDR","DM","hydrophobic","hydrophilic","neutral","acidic","polar","neg",18.259,0.124,-1.857,2.0881,-1.484,-1.99,30,66,0.42,3,3,26,0.0988593155893536,"loop",-0.333333333333333,4.65,0.0005749604714675,14.5802781289507,14.5802277940117,14.5801759034061,15.0663448164144,38,-18,0,0,-18,0,0,0,0,2,0,0,2,0,0,0,0,3,0,0,3,8,0,2,6,0.0556053811659192,-0.47984496124031,0.0760531472402917,-0.253026427962489,-0.520942408376963,0.315789473684211,0.134615384615385,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.083,0.59,"5:3","147/150","M:A:W:Y:E:F:H:Q:V:L:R:C:I",2.6796663501904,0.0010245352377104,0.816050632122416,3.28370108999367,3.35697961122125,99.553869259241,1.16376580853041,0.0005075351447614,3.29453387923245,2.60435121163486,147.676327006136,0.0001037975122989,"lineage4","dr_mutations_pyrazinamide","ASP",0,"SAMN02403544","SRR1169221_SRR1169287_SRR1167339_SRR1165647","lineage4.4.1.1","za","South Africa","pnca_p.tyr34asp","A","T","TYR","YA34","pnca_complex.pdb"
|
|
"Y34D","L4","PZA","Y","Y34",34,"D",NA,"MDR","DM","hydrophobic","hydrophilic","neutral","acidic","polar","neg",18.259,0.124,-1.857,2.0881,-1.484,-1.99,30,66,0.42,3,3,26,0.0988593155893536,"loop",-0.333333333333333,4.65,0.0005749604714675,14.5802781289507,14.5802277940117,14.5801759034061,15.0663448164144,38,-18,0,0,-18,0,0,0,0,2,0,0,2,0,0,0,0,3,0,0,3,8,0,2,6,0.0556053811659192,-0.47984496124031,0.0760531472402917,-0.253026427962489,-0.520942408376963,0.315789473684211,0.134615384615385,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.083,0.59,"5:3","147/150","M:A:W:Y:E:F:H:Q:V:L:R:C:I",2.6796663501904,0.0010245352377104,0.816050632122416,3.28370108999367,3.35697961122125,99.553869259241,1.16376580853041,0.0005075351447614,3.29453387923245,2.60435121163486,147.676327006136,0.0001037975122989,"lineage4","dr_mutations_pyrazinamide","ASP",0,"SAMN02350471","SRR1140934_SRR1019150","lineage4.4.1.1","za","South Africa","pnca_p.tyr34asp","A","T","TYR","YA34","pnca_complex.pdb"
|
|
"Y34D","L4","PZA","Y","Y34",34,"D",NA,"MDR","DM","hydrophobic","hydrophilic","neutral","acidic","polar","neg",18.259,0.124,-1.857,2.0881,-1.484,-1.99,30,66,0.42,3,3,26,0.0988593155893536,"loop",-0.333333333333333,4.65,0.0005749604714675,14.5802781289507,14.5802277940117,14.5801759034061,15.0663448164144,38,-18,0,0,-18,0,0,0,0,2,0,0,2,0,0,0,0,3,0,0,3,8,0,2,6,0.0556053811659192,-0.47984496124031,0.0760531472402917,-0.253026427962489,-0.520942408376963,0.315789473684211,0.134615384615385,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.083,0.59,"5:3","147/150","M:A:W:Y:E:F:H:Q:V:L:R:C:I",2.6796663501904,0.0010245352377104,0.816050632122416,3.28370108999367,3.35697961122125,99.553869259241,1.16376580853041,0.0005075351447614,3.29453387923245,2.60435121163486,147.676327006136,0.0001037975122989,"lineage4","dr_mutations_pyrazinamide","ASP",0,"SAMN02403547","SRR1169059_SRR1167393_SRR1172253_SRR1165664","lineage4.4.1.1","za","South Africa","pnca_p.tyr34asp","A","T","TYR","YA34","pnca_complex.pdb"
|
|
"Y34D","L4","PZA","Y","Y34",34,"D",NA,"MDR","DM","hydrophobic","hydrophilic","neutral","acidic","polar","neg",18.259,0.124,-1.857,2.0881,-1.484,-1.99,30,66,0.42,3,3,26,0.0988593155893536,"loop",-0.333333333333333,4.65,0.0005749604714675,14.5802781289507,14.5802277940117,14.5801759034061,15.0663448164144,38,-18,0,0,-18,0,0,0,0,2,0,0,2,0,0,0,0,3,0,0,3,8,0,2,6,0.0556053811659192,-0.47984496124031,0.0760531472402917,-0.253026427962489,-0.520942408376963,0.315789473684211,0.134615384615385,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.083,0.59,"5:3","147/150","M:A:W:Y:E:F:H:Q:V:L:R:C:I",2.6796663501904,0.0010245352377104,0.816050632122416,3.28370108999367,3.35697961122125,99.553869259241,1.16376580853041,0.0005075351447614,3.29453387923245,2.60435121163486,147.676327006136,0.0001037975122989,"lineage4","dr_mutations_pyrazinamide","ASP",0,"SAMN02403551","SRR1169245_SRR1169312_SRR1165706_SRR1165676","lineage4.4.1.1","za","South Africa","pnca_p.tyr34asp","A","T","TYR","YA34","pnca_complex.pdb"
|
|
"Y34D","L4","PZA","Y","Y34",34,"D",1,"MDR","DM","hydrophobic","hydrophilic","neutral","acidic","polar","neg",18.259,0.124,-1.857,2.0881,-1.484,-1.99,30,66,0.42,3,3,26,0.0988593155893536,"loop",-0.333333333333333,4.65,0.0005749604714675,14.5802781289507,14.5802277940117,14.5801759034061,15.0663448164144,38,-18,0,0,-18,0,0,0,0,2,0,0,2,0,0,0,0,3,0,0,3,8,0,2,6,0.0556053811659192,-0.47984496124031,0.0760531472402917,-0.253026427962489,-0.520942408376963,0.315789473684211,0.134615384615385,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.083,0.59,"5:3","147/150","M:A:W:Y:E:F:H:Q:V:L:R:C:I",2.6796663501904,0.0010245352377104,0.816050632122416,3.28370108999367,3.35697961122125,99.553869259241,1.16376580853041,0.0005075351447614,3.29453387923245,2.60435121163486,147.676327006136,0.0001037975122989,"lineage4","dr_mutations_pyrazinamide","ASP",0,"SAMN01925684","SRR924241_SRR847802","lineage4.4.1.1","za","South Africa","pnca_p.tyr34asp","A","T","TYR","YA34","pnca_complex.pdb"
|
|
"Y34D","L4","PZA","Y","Y34",34,"D",NA,"MDR","DM","hydrophobic","hydrophilic","neutral","acidic","polar","neg",18.259,0.124,-1.857,2.0881,-1.484,-1.99,30,66,0.42,3,3,26,0.0988593155893536,"loop",-0.333333333333333,4.65,0.0005749604714675,14.5802781289507,14.5802277940117,14.5801759034061,15.0663448164144,38,-18,0,0,-18,0,0,0,0,2,0,0,2,0,0,0,0,3,0,0,3,8,0,2,6,0.0556053811659192,-0.47984496124031,0.0760531472402917,-0.253026427962489,-0.520942408376963,0.315789473684211,0.134615384615385,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.083,0.59,"5:3","147/150","M:A:W:Y:E:F:H:Q:V:L:R:C:I",2.6796663501904,0.0010245352377104,0.816050632122416,3.28370108999367,3.35697961122125,99.553869259241,1.16376580853041,0.0005075351447614,3.29453387923245,2.60435121163486,147.676327006136,0.0001037975122989,"lineage4","dr_mutations_pyrazinamide","ASP",0,"SAMN02403586","SRR1165642_SRR1168964_SRR1167385_SRR1172276","lineage4.4.1.1","za","South Africa","pnca_p.tyr34asp","A","T","TYR","YA34","pnca_complex.pdb"
|
|
"Y34D","L4","PZA","Y","Y34",34,"D",NA,"MDR","DM","hydrophobic","hydrophilic","neutral","acidic","polar","neg",18.259,0.124,-1.857,2.0881,-1.484,-1.99,30,66,0.42,3,3,26,0.0988593155893536,"loop",-0.333333333333333,4.65,0.0005749604714675,14.5802781289507,14.5802277940117,14.5801759034061,15.0663448164144,38,-18,0,0,-18,0,0,0,0,2,0,0,2,0,0,0,0,3,0,0,3,8,0,2,6,0.0556053811659192,-0.47984496124031,0.0760531472402917,-0.253026427962489,-0.520942408376963,0.315789473684211,0.134615384615385,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.083,0.59,"5:3","147/150","M:A:W:Y:E:F:H:Q:V:L:R:C:I",2.6796663501904,0.0010245352377104,0.816050632122416,3.28370108999367,3.35697961122125,99.553869259241,1.16376580853041,0.0005075351447614,3.29453387923245,2.60435121163486,147.676327006136,0.0001037975122989,"lineage4","dr_mutations_pyrazinamide","ASP",0,"SAMN02403562","SRR1172221_SRR1169178","lineage4.4.1.1","za","South Africa","pnca_p.tyr34asp","A","T","TYR","YA34","pnca_complex.pdb"
|
|
"Y34D","L4","PZA","Y","Y34",34,"D",0,"MDR","DM","hydrophobic","hydrophilic","neutral","acidic","polar","neg",18.259,0.124,-1.857,2.0881,-1.484,-1.99,30,66,0.42,3,3,26,0.0988593155893536,"loop",-0.333333333333333,4.65,0.0005749604714675,14.5802781289507,14.5802277940117,14.5801759034061,15.0663448164144,38,-18,0,0,-18,0,0,0,0,2,0,0,2,0,0,0,0,3,0,0,3,8,0,2,6,0.0556053811659192,-0.47984496124031,0.0760531472402917,-0.253026427962489,-0.520942408376963,0.315789473684211,0.134615384615385,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.083,0.59,"5:3","147/150","M:A:W:Y:E:F:H:Q:V:L:R:C:I",2.6796663501904,0.0010245352377104,0.816050632122416,3.28370108999367,3.35697961122125,99.553869259241,1.16376580853041,0.0005075351447614,3.29453387923245,2.60435121163486,147.676327006136,0.0001037975122989,"lineage4","dr_mutations_pyrazinamide","ASP",0,"SAMN02053775","SRR833119_SRR833109","lineage4.4.1.1","za","South Africa","pnca_p.tyr34asp","A","T","TYR","YA34","pnca_complex.pdb"
|
|
"Y34D","L4","PZA","Y","Y34",34,"D",NA,"MDR","DM","hydrophobic","hydrophilic","neutral","acidic","polar","neg",18.259,0.124,-1.857,2.0881,-1.484,-1.99,30,66,0.42,3,3,26,0.0988593155893536,"loop",-0.333333333333333,4.65,0.0005749604714675,14.5802781289507,14.5802277940117,14.5801759034061,15.0663448164144,38,-18,0,0,-18,0,0,0,0,2,0,0,2,0,0,0,0,3,0,0,3,8,0,2,6,0.0556053811659192,-0.47984496124031,0.0760531472402917,-0.253026427962489,-0.520942408376963,0.315789473684211,0.134615384615385,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.083,0.59,"5:3","147/150","M:A:W:Y:E:F:H:Q:V:L:R:C:I",2.6796663501904,0.0010245352377104,0.816050632122416,3.28370108999367,3.35697961122125,99.553869259241,1.16376580853041,0.0005075351447614,3.29453387923245,2.60435121163486,147.676327006136,0.0001037975122989,"lineage4","dr_mutations_pyrazinamide","ASP",0,"SAMN02403518","SRR1167179_SRR1165253_SRR1175359_SRR1173144","lineage4.4.1.1","za","South Africa","pnca_p.tyr34asp","A","T","TYR","YA34","pnca_complex.pdb"
|
|
"Y34D","L4","PZA","Y","Y34",34,"D",1,"MDR","DM","hydrophobic","hydrophilic","neutral","acidic","polar","neg",18.259,0.124,-1.857,2.0881,-1.484,-1.99,30,66,0.42,3,3,26,0.0988593155893536,"loop",-0.333333333333333,4.65,0.0005749604714675,14.5802781289507,14.5802277940117,14.5801759034061,15.0663448164144,38,-18,0,0,-18,0,0,0,0,2,0,0,2,0,0,0,0,3,0,0,3,8,0,2,6,0.0556053811659192,-0.47984496124031,0.0760531472402917,-0.253026427962489,-0.520942408376963,0.315789473684211,0.134615384615385,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.083,0.59,"5:3","147/150","M:A:W:Y:E:F:H:Q:V:L:R:C:I",2.6796663501904,0.0010245352377104,0.816050632122416,3.28370108999367,3.35697961122125,99.553869259241,1.16376580853041,0.0005075351447614,3.29453387923245,2.60435121163486,147.676327006136,0.0001037975122989,"lineage4","dr_mutations_pyrazinamide","ASP",0,"ERR1034764","ERR1034764","lineage4.3.4.1","pe","Peru","pnca_p.tyr34asp","A","T","TYR","YA34","pnca_complex.pdb"
|
|
"Y34D","L4","PZA","Y","Y34",34,"D",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","neutral","acidic","polar","neg",18.259,0.124,-1.857,2.0881,-1.484,-1.99,30,66,0.42,3,3,26,0.0988593155893536,"loop",-0.333333333333333,4.65,0.0005749604714675,14.5802781289507,14.5802277940117,14.5801759034061,15.0663448164144,38,-18,0,0,-18,0,0,0,0,2,0,0,2,0,0,0,0,3,0,0,3,8,0,2,6,0.0556053811659192,-0.47984496124031,0.0760531472402917,-0.253026427962489,-0.520942408376963,0.315789473684211,0.134615384615385,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.083,0.59,"5:3","147/150","M:A:W:Y:E:F:H:Q:V:L:R:C:I",2.6796663501904,0.0010245352377104,0.816050632122416,3.28370108999367,3.35697961122125,99.553869259241,1.16376580853041,0.0005075351447614,3.29453387923245,2.60435121163486,147.676327006136,0.0001037975122989,"lineage4","dr_mutations_pyrazinamide","ASP",0,"SAMN02350490","SRR1019173_SRR1140926","lineage4.4.1.1","za","South Africa","pnca_p.tyr34asp","A","T","TYR","YA34","pnca_complex.pdb"
|
|
"Y34D","L4","PZA","Y","Y34",34,"D",0,"MDR","DM","hydrophobic","hydrophilic","neutral","acidic","polar","neg",18.259,0.124,-1.857,2.0881,-1.484,-1.99,30,66,0.42,3,3,26,0.0988593155893536,"loop",-0.333333333333333,4.65,0.0005749604714675,14.5802781289507,14.5802277940117,14.5801759034061,15.0663448164144,38,-18,0,0,-18,0,0,0,0,2,0,0,2,0,0,0,0,3,0,0,3,8,0,2,6,0.0556053811659192,-0.47984496124031,0.0760531472402917,-0.253026427962489,-0.520942408376963,0.315789473684211,0.134615384615385,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.083,0.59,"5:3","147/150","M:A:W:Y:E:F:H:Q:V:L:R:C:I",2.6796663501904,0.0010245352377104,0.816050632122416,3.28370108999367,3.35697961122125,99.553869259241,1.16376580853041,0.0005075351447614,3.29453387923245,2.60435121163486,147.676327006136,0.0001037975122989,"lineage4","dr_mutations_pyrazinamide","ASP",0,"SAMN01828244","SRR832993_SRR833022_SRR833098_SRR833076_SRR833132_SRR833030","lineage4.4.1.1","za","South Africa","pnca_p.tyr34asp","A","T","TYR","YA34","pnca_complex.pdb"
|
|
"Y34D","L4","PZA","Y","Y34",34,"D",NA,"MDR","DM","hydrophobic","hydrophilic","neutral","acidic","polar","neg",18.259,0.124,-1.857,2.0881,-1.484,-1.99,30,66,0.42,3,3,26,0.0988593155893536,"loop",-0.333333333333333,4.65,0.0005749604714675,14.5802781289507,14.5802277940117,14.5801759034061,15.0663448164144,38,-18,0,0,-18,0,0,0,0,2,0,0,2,0,0,0,0,3,0,0,3,8,0,2,6,0.0556053811659192,-0.47984496124031,0.0760531472402917,-0.253026427962489,-0.520942408376963,0.315789473684211,0.134615384615385,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.083,0.59,"5:3","147/150","M:A:W:Y:E:F:H:Q:V:L:R:C:I",2.6796663501904,0.0010245352377104,0.816050632122416,3.28370108999367,3.35697961122125,99.553869259241,1.16376580853041,0.0005075351447614,3.29453387923245,2.60435121163486,147.676327006136,0.0001037975122989,"lineage4","dr_mutations_pyrazinamide","ASP",0,"004-2","ERR1750880","lineage4.4.1.1","zw","","pnca_p.tyr34asp","A","T","TYR","YA34","pnca_complex.pdb"
|
|
"Y34D","L4","PZA","Y","Y34",34,"D",NA,"MDR","DM","hydrophobic","hydrophilic","neutral","acidic","polar","neg",18.259,0.124,-1.857,2.0881,-1.484,-1.99,30,66,0.42,3,3,26,0.0988593155893536,"loop",-0.333333333333333,4.65,0.0005749604714675,14.5802781289507,14.5802277940117,14.5801759034061,15.0663448164144,38,-18,0,0,-18,0,0,0,0,2,0,0,2,0,0,0,0,3,0,0,3,8,0,2,6,0.0556053811659192,-0.47984496124031,0.0760531472402917,-0.253026427962489,-0.520942408376963,0.315789473684211,0.134615384615385,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.083,0.59,"5:3","147/150","M:A:W:Y:E:F:H:Q:V:L:R:C:I",2.6796663501904,0.0010245352377104,0.816050632122416,3.28370108999367,3.35697961122125,99.553869259241,1.16376580853041,0.0005075351447614,3.29453387923245,2.60435121163486,147.676327006136,0.0001037975122989,"lineage4","dr_mutations_pyrazinamide","ASP",0,"SAMN02585988","SRR1173040_SRR1172753","lineage4.4.1.1","za","South Africa","pnca_p.tyr34asp","A","T","TYR","YA34","pnca_complex.pdb"
|
|
"Y34D","L4","PZA","Y","Y34",34,"D",NA,"MDR","DM","hydrophobic","hydrophilic","neutral","acidic","polar","neg",18.259,0.124,-1.857,2.0881,-1.484,-1.99,30,66,0.42,3,3,26,0.0988593155893536,"loop",-0.333333333333333,4.65,0.0005749604714675,14.5802781289507,14.5802277940117,14.5801759034061,15.0663448164144,38,-18,0,0,-18,0,0,0,0,2,0,0,2,0,0,0,0,3,0,0,3,8,0,2,6,0.0556053811659192,-0.47984496124031,0.0760531472402917,-0.253026427962489,-0.520942408376963,0.315789473684211,0.134615384615385,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.083,0.59,"5:3","147/150","M:A:W:Y:E:F:H:Q:V:L:R:C:I",2.6796663501904,0.0010245352377104,0.816050632122416,3.28370108999367,3.35697961122125,99.553869259241,1.16376580853041,0.0005075351447614,3.29453387923245,2.60435121163486,147.676327006136,0.0001037975122989,"lineage4","dr_mutations_pyrazinamide","ASP",0,"SAMN02350484","SRR1019159_SRR1140945","lineage4.4.1.1","za","South Africa","pnca_p.tyr34asp","A","T","TYR","YA34","pnca_complex.pdb"
|
|
"Y34D","L4","PZA","Y","Y34",34,"D",NA,"MDR","DM","hydrophobic","hydrophilic","neutral","acidic","polar","neg",18.259,0.124,-1.857,2.0881,-1.484,-1.99,30,66,0.42,3,3,26,0.0988593155893536,"loop",-0.333333333333333,4.65,0.0005749604714675,14.5802781289507,14.5802277940117,14.5801759034061,15.0663448164144,38,-18,0,0,-18,0,0,0,0,2,0,0,2,0,0,0,0,3,0,0,3,8,0,2,6,0.0556053811659192,-0.47984496124031,0.0760531472402917,-0.253026427962489,-0.520942408376963,0.315789473684211,0.134615384615385,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.083,0.59,"5:3","147/150","M:A:W:Y:E:F:H:Q:V:L:R:C:I",2.6796663501904,0.0010245352377104,0.816050632122416,3.28370108999367,3.35697961122125,99.553869259241,1.16376580853041,0.0005075351447614,3.29453387923245,2.60435121163486,147.676327006136,0.0001037975122989,"lineage4","dr_mutations_pyrazinamide","ASP",0,"SAMN02585983","SRR1175329_SRR1173087","lineage4.4.1.1","za","South Africa","pnca_p.tyr34asp","A","T","TYR","YA34","pnca_complex.pdb"
|
|
"Y34D","L4","PZA","Y","Y34",34,"D",NA,"MDR","DM","hydrophobic","hydrophilic","neutral","acidic","polar","neg",18.259,0.124,-1.857,2.0881,-1.484,-1.99,30,66,0.42,3,3,26,0.0988593155893536,"loop",-0.333333333333333,4.65,0.0005749604714675,14.5802781289507,14.5802277940117,14.5801759034061,15.0663448164144,38,-18,0,0,-18,0,0,0,0,2,0,0,2,0,0,0,0,3,0,0,3,8,0,2,6,0.0556053811659192,-0.47984496124031,0.0760531472402917,-0.253026427962489,-0.520942408376963,0.315789473684211,0.134615384615385,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.083,0.59,"5:3","147/150","M:A:W:Y:E:F:H:Q:V:L:R:C:I",2.6796663501904,0.0010245352377104,0.816050632122416,3.28370108999367,3.35697961122125,99.553869259241,1.16376580853041,0.0005075351447614,3.29453387923245,2.60435121163486,147.676327006136,0.0001037975122989,"lineage4","dr_mutations_pyrazinamide","ASP",0,"SAMN02403552","SRR1167354_SRR1169262_SRR1165702_SRR1169240","lineage4.4.1.1","za","South Africa","pnca_p.tyr34asp","A","T","TYR","YA34","pnca_complex.pdb"
|
|
"Y34D","L4","PZA","Y","Y34",34,"D",NA,"MDR","DM","hydrophobic","hydrophilic","neutral","acidic","polar","neg",18.259,0.124,-1.857,2.0881,-1.484,-1.99,30,66,0.42,3,3,26,0.0988593155893536,"loop",-0.333333333333333,4.65,0.0005749604714675,14.5802781289507,14.5802277940117,14.5801759034061,15.0663448164144,38,-18,0,0,-18,0,0,0,0,2,0,0,2,0,0,0,0,3,0,0,3,8,0,2,6,0.0556053811659192,-0.47984496124031,0.0760531472402917,-0.253026427962489,-0.520942408376963,0.315789473684211,0.134615384615385,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.083,0.59,"5:3","147/150","M:A:W:Y:E:F:H:Q:V:L:R:C:I",2.6796663501904,0.0010245352377104,0.816050632122416,3.28370108999367,3.35697961122125,99.553869259241,1.16376580853041,0.0005075351447614,3.29453387923245,2.60435121163486,147.676327006136,0.0001037975122989,"lineage4","dr_mutations_pyrazinamide","ASP",0,"SAMN02403565","SRR1169275_SRR1167390_SRR1169211_SRR1165650","lineage4.4.1.1","za","South Africa","pnca_p.tyr34asp","A","T","TYR","YA34","pnca_complex.pdb"
|
|
"Y34D","L4","PZA","Y","Y34",34,"D",1,"MDR","DM","hydrophobic","hydrophilic","neutral","acidic","polar","neg",18.259,0.124,-1.857,2.0881,-1.484,-1.99,30,66,0.42,3,3,26,0.0988593155893536,"loop",-0.333333333333333,4.65,0.0005749604714675,14.5802781289507,14.5802277940117,14.5801759034061,15.0663448164144,38,-18,0,0,-18,0,0,0,0,2,0,0,2,0,0,0,0,3,0,0,3,8,0,2,6,0.0556053811659192,-0.47984496124031,0.0760531472402917,-0.253026427962489,-0.520942408376963,0.315789473684211,0.134615384615385,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.083,0.59,"5:3","147/150","M:A:W:Y:E:F:H:Q:V:L:R:C:I",2.6796663501904,0.0010245352377104,0.816050632122416,3.28370108999367,3.35697961122125,99.553869259241,1.16376580853041,0.0005075351447614,3.29453387923245,2.60435121163486,147.676327006136,0.0001037975122989,"lineage4","dr_mutations_pyrazinamide","ASP",0,"ERR2515410","ERR2515410","lineage4.4.1.1","za","South Africa","pnca_p.tyr34asp","A","T","TYR","YA34","pnca_complex.pdb"
|
|
"Y34D","L4","PZA","Y","Y34",34,"D",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","neutral","acidic","polar","neg",18.259,0.124,-1.857,2.0881,-1.484,-1.99,30,66,0.42,3,3,26,0.0988593155893536,"loop",-0.333333333333333,4.65,0.0005749604714675,14.5802781289507,14.5802277940117,14.5801759034061,15.0663448164144,38,-18,0,0,-18,0,0,0,0,2,0,0,2,0,0,0,0,3,0,0,3,8,0,2,6,0.0556053811659192,-0.47984496124031,0.0760531472402917,-0.253026427962489,-0.520942408376963,0.315789473684211,0.134615384615385,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.083,0.59,"5:3","147/150","M:A:W:Y:E:F:H:Q:V:L:R:C:I",2.6796663501904,0.0010245352377104,0.816050632122416,3.28370108999367,3.35697961122125,99.553869259241,1.16376580853041,0.0005075351447614,3.29453387923245,2.60435121163486,147.676327006136,0.0001037975122989,"lineage4","dr_mutations_pyrazinamide","ASP",0,"SAMN02403555","SRR1167364_SRR1165651_SRR1172259_SRR1169176","lineage4.4.1.1","sz","Swaziland","pnca_p.tyr34asp","A","T","TYR","YA34","pnca_complex.pdb"
|
|
"Y34D","L4","PZA","Y","Y34",34,"D",NA,"MDR","DM","hydrophobic","hydrophilic","neutral","acidic","polar","neg",18.259,0.124,-1.857,2.0881,-1.484,-1.99,30,66,0.42,3,3,26,0.0988593155893536,"loop",-0.333333333333333,4.65,0.0005749604714675,14.5802781289507,14.5802277940117,14.5801759034061,15.0663448164144,38,-18,0,0,-18,0,0,0,0,2,0,0,2,0,0,0,0,3,0,0,3,8,0,2,6,0.0556053811659192,-0.47984496124031,0.0760531472402917,-0.253026427962489,-0.520942408376963,0.315789473684211,0.134615384615385,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.083,0.59,"5:3","147/150","M:A:W:Y:E:F:H:Q:V:L:R:C:I",2.6796663501904,0.0010245352377104,0.816050632122416,3.28370108999367,3.35697961122125,99.553869259241,1.16376580853041,0.0005075351447614,3.29453387923245,2.60435121163486,147.676327006136,0.0001037975122989,"lineage4","dr_mutations_pyrazinamide","ASP",0,"SAMN02350443","SRR1062850_SRR1011479","lineage4.4.1.1","za","South Africa","pnca_p.tyr34asp","A","T","TYR","YA34","pnca_complex.pdb"
|
|
"Y34D","L4","PZA","Y","Y34",34,"D",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","neutral","acidic","polar","neg",18.259,0.124,-1.857,2.0881,-1.484,-1.99,30,66,0.42,3,3,26,0.0988593155893536,"loop",-0.333333333333333,4.65,0.0005749604714675,14.5802781289507,14.5802277940117,14.5801759034061,15.0663448164144,38,-18,0,0,-18,0,0,0,0,2,0,0,2,0,0,0,0,3,0,0,3,8,0,2,6,0.0556053811659192,-0.47984496124031,0.0760531472402917,-0.253026427962489,-0.520942408376963,0.315789473684211,0.134615384615385,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.083,0.59,"5:3","147/150","M:A:W:Y:E:F:H:Q:V:L:R:C:I",2.6796663501904,0.0010245352377104,0.816050632122416,3.28370108999367,3.35697961122125,99.553869259241,1.16376580853041,0.0005075351447614,3.29453387923245,2.60435121163486,147.676327006136,0.0001037975122989,"lineage4","dr_mutations_pyrazinamide","ASP",0,"SAMN02350489","SRR1140929_SRR1019168","lineage4.4.1.1","za","South Africa","pnca_p.tyr34asp","A","T","TYR","YA34","pnca_complex.pdb"
|
|
"Y34D","L4","PZA","Y","Y34",34,"D",NA,"MDR","DM","hydrophobic","hydrophilic","neutral","acidic","polar","neg",18.259,0.124,-1.857,2.0881,-1.484,-1.99,30,66,0.42,3,3,26,0.0988593155893536,"loop",-0.333333333333333,4.65,0.0005749604714675,14.5802781289507,14.5802277940117,14.5801759034061,15.0663448164144,38,-18,0,0,-18,0,0,0,0,2,0,0,2,0,0,0,0,3,0,0,3,8,0,2,6,0.0556053811659192,-0.47984496124031,0.0760531472402917,-0.253026427962489,-0.520942408376963,0.315789473684211,0.134615384615385,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.083,0.59,"5:3","147/150","M:A:W:Y:E:F:H:Q:V:L:R:C:I",2.6796663501904,0.0010245352377104,0.816050632122416,3.28370108999367,3.35697961122125,99.553869259241,1.16376580853041,0.0005075351447614,3.29453387923245,2.60435121163486,147.676327006136,0.0001037975122989,"lineage4","dr_mutations_pyrazinamide","ASP",0,"SAMN02586001","SRR1173352_SRR1184347_SRR1196570_SRR1173522","lineage4.4.1.1","za","South Africa","pnca_p.tyr34asp","A","T","TYR","YA34","pnca_complex.pdb"
|
|
"Y34D","L4","PZA","Y","Y34",34,"D",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","neutral","acidic","polar","neg",18.259,0.124,-1.857,2.0881,-1.484,-1.99,30,66,0.42,3,3,26,0.0988593155893536,"loop",-0.333333333333333,4.65,0.0005749604714675,14.5802781289507,14.5802277940117,14.5801759034061,15.0663448164144,38,-18,0,0,-18,0,0,0,0,2,0,0,2,0,0,0,0,3,0,0,3,8,0,2,6,0.0556053811659192,-0.47984496124031,0.0760531472402917,-0.253026427962489,-0.520942408376963,0.315789473684211,0.134615384615385,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.083,0.59,"5:3","147/150","M:A:W:Y:E:F:H:Q:V:L:R:C:I",2.6796663501904,0.0010245352377104,0.816050632122416,3.28370108999367,3.35697961122125,99.553869259241,1.16376580853041,0.0005075351447614,3.29453387923245,2.60435121163486,147.676327006136,0.0001037975122989,"lineage4","dr_mutations_pyrazinamide","ASP",0,"SAMN02586054","SRR1184313_SRR1172781_SRR1196580_SRR1175046","lineage4.4.1.1","za","South Africa","pnca_p.tyr34asp","A","T","TYR","YA34","pnca_complex.pdb"
|
|
"Y34D","L4","PZA","Y","Y34",34,"D",NA,"MDR","DM","hydrophobic","hydrophilic","neutral","acidic","polar","neg",18.259,0.124,-1.857,2.0881,-1.484,-1.99,30,66,0.42,3,3,26,0.0988593155893536,"loop",-0.333333333333333,4.65,0.0005749604714675,14.5802781289507,14.5802277940117,14.5801759034061,15.0663448164144,38,-18,0,0,-18,0,0,0,0,2,0,0,2,0,0,0,0,3,0,0,3,8,0,2,6,0.0556053811659192,-0.47984496124031,0.0760531472402917,-0.253026427962489,-0.520942408376963,0.315789473684211,0.134615384615385,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.083,0.59,"5:3","147/150","M:A:W:Y:E:F:H:Q:V:L:R:C:I",2.6796663501904,0.0010245352377104,0.816050632122416,3.28370108999367,3.35697961122125,99.553869259241,1.16376580853041,0.0005075351447614,3.29453387923245,2.60435121163486,147.676327006136,0.0001037975122989,"lineage4","dr_mutations_pyrazinamide","ASP",0,"SAMN02403543","SRR1165703_SRR1167361_SRR1172061_SRR1169160","lineage4.4.1.1","za","South Africa","pnca_p.tyr34asp","A","T","TYR","YA34","pnca_complex.pdb"
|
|
"Y34D","L4","PZA","Y","Y34",34,"D",1,"MDR","DM","hydrophobic","hydrophilic","neutral","acidic","polar","neg",18.259,0.124,-1.857,2.0881,-1.484,-1.99,30,66,0.42,3,3,26,0.0988593155893536,"loop",-0.333333333333333,4.65,0.0005749604714675,14.5802781289507,14.5802277940117,14.5801759034061,15.0663448164144,38,-18,0,0,-18,0,0,0,0,2,0,0,2,0,0,0,0,3,0,0,3,8,0,2,6,0.0556053811659192,-0.47984496124031,0.0760531472402917,-0.253026427962489,-0.520942408376963,0.315789473684211,0.134615384615385,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.083,0.59,"5:3","147/150","M:A:W:Y:E:F:H:Q:V:L:R:C:I",2.6796663501904,0.0010245352377104,0.816050632122416,3.28370108999367,3.35697961122125,99.553869259241,1.16376580853041,0.0005075351447614,3.29453387923245,2.60435121163486,147.676327006136,0.0001037975122989,"lineage4","dr_mutations_pyrazinamide","ASP",0,"ERR2515265","ERR2515265","lineage4.4.1.1","za","South Africa","pnca_p.tyr34asp","A","T","TYR","YA34","pnca_complex.pdb"
|
|
"Y34S","L2","PZA","Y","Y34",34,"S",0,"MDR","DM","hydrophobic","hydrophilic","neutral","neutral","polar","polar",18.259,-0.316,-3.224,0.32836,-1.692,-3.31,13,59,0.42,3,3,26,0.0988593155893536,"loop",-0.333333333333333,4.65,0.0001437401178668,1.2119588062211,4.5970013133425e-05,0,1.01056822389159e-25,48,10,0,2,8,0,0,0,0,-2,0,-4,2,0,0,0,0,2,0,0,2,10,0,2,10,-0.0800405268490375,-0.833074935400517,0.0119595859526949,-0.28849104859335,-0.866492146596859,0.136842105263158,0.134615384615385,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.083,0.59,"5:3","147/150","M:A:W:Y:E:F:H:Q:V:L:R:C:I",-9.98752126245062,0.942832958100734,139.277183325398,-0.071709672926946,NA,144471.706314878,0.0834878586628579,1,0,0,25.8386585962163,0.999999999999746,"lineage2","dr_mutations_pyrazinamide","SER",0,"ERR2510443","ERR2510443","lineage2.2.1","pk","Pakistan","pnca_p.tyr34ser","A","T","TYR","YA34","pnca_complex.pdb"
|
|
"Y34S","L4","PZA","Y","Y34",34,"S",NA,"MDR","DM","hydrophobic","hydrophilic","neutral","neutral","polar","polar",18.259,-0.316,-3.224,0.32836,-1.692,-3.31,13,59,0.42,3,3,26,0.0988593155893536,"loop",-0.333333333333333,4.65,0.0001437401178668,1.2119588062211,4.5970013133425e-05,0,1.01056822389159e-25,48,10,0,2,8,0,0,0,0,-2,0,-4,2,0,0,0,0,2,0,0,2,10,0,2,10,-0.0800405268490375,-0.833074935400517,0.0119595859526949,-0.28849104859335,-0.866492146596859,0.136842105263158,0.134615384615385,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.083,0.59,"5:3","147/150","M:A:W:Y:E:F:H:Q:V:L:R:C:I",-9.98752126245062,0.942832958100734,139.277183325398,-0.071709672926946,NA,144471.706314878,0.0834878586628579,1,0,0,25.8386585962163,0.999999999999746,"lineage4","dr_mutations_pyrazinamide","SER",0,"SRS797453","SRR1723993","lineage4.4.2","cn","China:Zhejiang","pnca_p.tyr34ser","A","T","TYR","YA34","pnca_complex.pdb"
|
|
"Y34S","L4","PZA","Y","Y34",34,"S",0,"MDR","DM","hydrophobic","hydrophilic","neutral","neutral","polar","polar",18.259,-0.316,-3.224,0.32836,-1.692,-3.31,13,59,0.42,3,3,26,0.0988593155893536,"loop",-0.333333333333333,4.65,0.0001437401178668,1.2119588062211,4.5970013133425e-05,0,1.01056822389159e-25,48,10,0,2,8,0,0,0,0,-2,0,-4,2,0,0,0,0,2,0,0,2,10,0,2,10,-0.0800405268490375,-0.833074935400517,0.0119595859526949,-0.28849104859335,-0.866492146596859,0.136842105263158,0.134615384615385,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.083,0.59,"5:3","147/150","M:A:W:Y:E:F:H:Q:V:L:R:C:I",-9.98752126245062,0.942832958100734,139.277183325398,-0.071709672926946,NA,144471.706314878,0.0834878586628579,1,0,0,25.8386585962163,0.999999999999746,"lineage4","dr_mutations_pyrazinamide","SER",0,"MDR_11166","SRR6824331","lineage4.4.2","cn","China: Luqiao District, Taizhou City, Zhejiang Province","pnca_p.tyr34ser","A","T","TYR","YA34","pnca_complex.pdb"
|
|
"Y34S","L4","PZA","Y","Y34",34,"S",NA,"MDR","DM","hydrophobic","hydrophilic","neutral","neutral","polar","polar",18.259,-0.316,-3.224,0.32836,-1.692,-3.31,13,59,0.42,3,3,26,0.0988593155893536,"loop",-0.333333333333333,4.65,0.0001437401178668,1.2119588062211,4.5970013133425e-05,0,1.01056822389159e-25,48,10,0,2,8,0,0,0,0,-2,0,-4,2,0,0,0,0,2,0,0,2,10,0,2,10,-0.0800405268490375,-0.833074935400517,0.0119595859526949,-0.28849104859335,-0.866492146596859,0.136842105263158,0.134615384615385,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.083,0.59,"5:3","147/150","M:A:W:Y:E:F:H:Q:V:L:R:C:I",-9.98752126245062,0.942832958100734,139.277183325398,-0.071709672926946,NA,144471.706314878,0.0834878586628579,1,0,0,25.8386585962163,0.999999999999746,"lineage4","dr_mutations_pyrazinamide","SER",0,"ERR2179653","ERR2179653","lineage4.4.2","cn","China","pnca_p.tyr34ser","A","T","TYR","YA34","pnca_complex.pdb"
|
|
"L35M","L4","PZA","L","L35",35,"M",NA,"MDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",17.42,-1.12,-1.162,-0.61263,-0.928,-0.38,-4,53,0.183,4,4,35,0.174129353233831,"loop",1.43333333333333,4.69,NA,NA,NA,NA,NA,-10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-1,0,2,0,-2,2,-0.283687943262411,-0.300258397932817,-0.11778628008921,-0.158226768968457,-0.0994764397905759,-0.043010752688172,0.0586538461538462,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","neutral",-0.038,0.389,"5:4","147/150","G:A:S:M:T:Q:V:L:I",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage4","other_mutations_pyrazinamide","MET",0,"SAMN02231181","SRR1162468_SRR1162694_SRR1103486","lineage4.1","ml","Mali","pnca_p.leu35met","A","T","LEU","LA35","pnca_complex.pdb"
|
|
"L35P","L2","PZA","L","L35",35,"P",0,"Pre-XDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",17.42,-0.954,-2.054,8.91998,-2.108,-1.48,82,91,0.183,4,4,35,0.174129353233831,"loop",1.43333333333333,4.69,0.0005749604714675,4.85515789473684,4.85515785897614,4.85442845338892,4.01139112494925,24,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,2,-5,1,8,0,0,8,-0.241641337386018,-0.530749354005168,0.324885088032401,-0.359420289855072,-0.387434554973822,0.863157894736842,0.0586538461538462,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","147/150","G:A:S:M:T:Q:V:L:I",1.58004161593687,0.0255237229775361,0.70746570614631,2.23338262506551,1.14726850666833,20.5466864308597,0.686203358177678,0.033386534669467,1.47642865587913,0.903495684237988,26.0627135254866,0.0451938468216249,"lineage2","dr_mutations_pyrazinamide","PRO",0,"ERR2513880","ERR2513880","lineage2.2.1","gb","UK","pnca_p.leu35pro","A","T","LEU","LA35","pnca_complex.pdb"
|
|
"L35P","L2","PZA","L","L35",35,"P",1,"Pre-XDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",17.42,-0.954,-2.054,8.91998,-2.108,-1.48,82,91,0.183,4,4,35,0.174129353233831,"loop",1.43333333333333,4.69,0.0005749604714675,4.85515789473684,4.85515785897614,4.85442845338892,4.01139112494925,24,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,2,-5,1,8,0,0,8,-0.241641337386018,-0.530749354005168,0.324885088032401,-0.359420289855072,-0.387434554973822,0.863157894736842,0.0586538461538462,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","147/150","G:A:S:M:T:Q:V:L:I",1.58004161593687,0.0255237229775361,0.70746570614631,2.23338262506551,1.14726850666833,20.5466864308597,0.686203358177678,0.033386534669467,1.47642865587913,0.903495684237988,26.0627135254866,0.0451938468216249,"lineage2","dr_mutations_pyrazinamide","PRO",0,"ERR2041783","ERR2041783","lineage2.2.1","rs","Serbia","pnca_p.leu35pro","A","T","LEU","LA35","pnca_complex.pdb"
|
|
"L35P","L2","PZA","L","L35",35,"P",0,"Pre-XDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",17.42,-0.954,-2.054,8.91998,-2.108,-1.48,82,91,0.183,4,4,35,0.174129353233831,"loop",1.43333333333333,4.69,0.0005749604714675,4.85515789473684,4.85515785897614,4.85442845338892,4.01139112494925,24,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,2,-5,1,8,0,0,8,-0.241641337386018,-0.530749354005168,0.324885088032401,-0.359420289855072,-0.387434554973822,0.863157894736842,0.0586538461538462,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","147/150","G:A:S:M:T:Q:V:L:I",1.58004161593687,0.0255237229775361,0.70746570614631,2.23338262506551,1.14726850666833,20.5466864308597,0.686203358177678,0.033386534669467,1.47642865587913,0.903495684237988,26.0627135254866,0.0451938468216249,"lineage2","dr_mutations_pyrazinamide","PRO",0,"7627226,SAMN05276493","SRR3675523","lineage2.2.1","gb","UK","pnca_p.leu35pro","A","T","LEU","LA35","pnca_complex.pdb"
|
|
"L35P","L3","PZA","L","L35",35,"P",1,"MDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",17.42,-0.954,-2.054,8.91998,-2.108,-1.48,82,91,0.183,4,4,35,0.174129353233831,"loop",1.43333333333333,4.69,0.0005749604714675,4.85515789473684,4.85515785897614,4.85442845338892,4.01139112494925,24,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,2,-5,1,8,0,0,8,-0.241641337386018,-0.530749354005168,0.324885088032401,-0.359420289855072,-0.387434554973822,0.863157894736842,0.0586538461538462,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","147/150","G:A:S:M:T:Q:V:L:I",1.58004161593687,0.0255237229775361,0.70746570614631,2.23338262506551,1.14726850666833,20.5466864308597,0.686203358177678,0.033386534669467,1.47642865587913,0.903495684237988,26.0627135254866,0.0451938468216249,"lineage3","dr_mutations_pyrazinamide","PRO",0,"ERR2510503","ERR2510503","lineage3","pk","Pakistan","pnca_p.leu35pro","A","T","LEU","LA35","pnca_complex.pdb"
|
|
"L35P","L2","PZA","L","L35",35,"P",1,"MDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",17.42,-0.954,-2.054,8.91998,-2.108,-1.48,82,91,0.183,4,4,35,0.174129353233831,"loop",1.43333333333333,4.69,0.0005749604714675,4.85515789473684,4.85515785897614,4.85442845338892,4.01139112494925,24,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,2,-5,1,8,0,0,8,-0.241641337386018,-0.530749354005168,0.324885088032401,-0.359420289855072,-0.387434554973822,0.863157894736842,0.0586538461538462,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","147/150","G:A:S:M:T:Q:V:L:I",1.58004161593687,0.0255237229775361,0.70746570614631,2.23338262506551,1.14726850666833,20.5466864308597,0.686203358177678,0.033386534669467,1.47642865587913,0.903495684237988,26.0627135254866,0.0451938468216249,"lineage2","dr_mutations_pyrazinamide","PRO",0,"ERR2516387","ERR2516387","lineage2.2.1","be","Belgium","pnca_p.leu35pro","A","T","LEU","LA35","pnca_complex.pdb"
|
|
"L35P","L2","PZA","L","L35",35,"P",1,"MDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",17.42,-0.954,-2.054,8.91998,-2.108,-1.48,82,91,0.183,4,4,35,0.174129353233831,"loop",1.43333333333333,4.69,0.0005749604714675,4.85515789473684,4.85515785897614,4.85442845338892,4.01139112494925,24,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,2,-5,1,8,0,0,8,-0.241641337386018,-0.530749354005168,0.324885088032401,-0.359420289855072,-0.387434554973822,0.863157894736842,0.0586538461538462,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","147/150","G:A:S:M:T:Q:V:L:I",1.58004161593687,0.0255237229775361,0.70746570614631,2.23338262506551,1.14726850666833,20.5466864308597,0.686203358177678,0.033386534669467,1.47642865587913,0.903495684237988,26.0627135254866,0.0451938468216249,"lineage2","dr_mutations_pyrazinamide","PRO",0,"MDR_15127","SRR6824428","lineage2.2.1","cn","China: Zhoucun District, Zibo City, Shandong Province","pnca_p.leu35pro","A","T","LEU","LA35","pnca_complex.pdb"
|
|
"L35P","L2","PZA","L","L35",35,"P",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",17.42,-0.954,-2.054,8.91998,-2.108,-1.48,82,91,0.183,4,4,35,0.174129353233831,"loop",1.43333333333333,4.69,0.0005749604714675,4.85515789473684,4.85515785897614,4.85442845338892,4.01139112494925,24,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,2,-5,1,8,0,0,8,-0.241641337386018,-0.530749354005168,0.324885088032401,-0.359420289855072,-0.387434554973822,0.863157894736842,0.0586538461538462,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","147/150","G:A:S:M:T:Q:V:L:I",1.58004161593687,0.0255237229775361,0.70746570614631,2.23338262506551,1.14726850666833,20.5466864308597,0.686203358177678,0.033386534669467,1.47642865587913,0.903495684237988,26.0627135254866,0.0451938468216249,"lineage2","dr_mutations_pyrazinamide","PRO",0,"SRR5065371","SRR5065371","lineage2.2.2","vn","Vietnam","pnca_p.leu35pro","A","T","LEU","LA35","pnca_complex.pdb"
|
|
"L35P","L2","PZA","L","L35",35,"P",0,"Pre-XDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",17.42,-0.954,-2.054,8.91998,-2.108,-1.48,82,91,0.183,4,4,35,0.174129353233831,"loop",1.43333333333333,4.69,0.0005749604714675,4.85515789473684,4.85515785897614,4.85442845338892,4.01139112494925,24,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,2,-5,1,8,0,0,8,-0.241641337386018,-0.530749354005168,0.324885088032401,-0.359420289855072,-0.387434554973822,0.863157894736842,0.0586538461538462,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","147/150","G:A:S:M:T:Q:V:L:I",1.58004161593687,0.0255237229775361,0.70746570614631,2.23338262506551,1.14726850666833,20.5466864308597,0.686203358177678,0.033386534669467,1.47642865587913,0.903495684237988,26.0627135254866,0.0451938468216249,"lineage2","dr_mutations_pyrazinamide","PRO",0,"7626675,SAMN05276382","SRR3675289","lineage2.2.1","gb","UK","pnca_p.leu35pro","A","T","LEU","LA35","pnca_complex.pdb"
|
|
"L35P","L2","PZA","L","L35",35,"P",0,"Pre-XDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",17.42,-0.954,-2.054,8.91998,-2.108,-1.48,82,91,0.183,4,4,35,0.174129353233831,"loop",1.43333333333333,4.69,0.0005749604714675,4.85515789473684,4.85515785897614,4.85442845338892,4.01139112494925,24,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,2,-5,1,8,0,0,8,-0.241641337386018,-0.530749354005168,0.324885088032401,-0.359420289855072,-0.387434554973822,0.863157894736842,0.0586538461538462,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","147/150","G:A:S:M:T:Q:V:L:I",1.58004161593687,0.0255237229775361,0.70746570614631,2.23338262506551,1.14726850666833,20.5466864308597,0.686203358177678,0.033386534669467,1.47642865587913,0.903495684237988,26.0627135254866,0.0451938468216249,"lineage2","dr_mutations_pyrazinamide","PRO",0,"SAMN05276356,7626930","SRR3675262","lineage2.2.1","gb","UK","pnca_p.leu35pro","A","T","LEU","LA35","pnca_complex.pdb"
|
|
"L35P","L2","PZA","L","L35",35,"P",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",17.42,-0.954,-2.054,8.91998,-2.108,-1.48,82,91,0.183,4,4,35,0.174129353233831,"loop",1.43333333333333,4.69,0.0005749604714675,4.85515789473684,4.85515785897614,4.85442845338892,4.01139112494925,24,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,2,-5,1,8,0,0,8,-0.241641337386018,-0.530749354005168,0.324885088032401,-0.359420289855072,-0.387434554973822,0.863157894736842,0.0586538461538462,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","147/150","G:A:S:M:T:Q:V:L:I",1.58004161593687,0.0255237229775361,0.70746570614631,2.23338262506551,1.14726850666833,20.5466864308597,0.686203358177678,0.033386534669467,1.47642865587913,0.903495684237988,26.0627135254866,0.0451938468216249,"lineage2","dr_mutations_pyrazinamide","PRO",0,"SAMN02360553","SRR1048847_SRR1048846_SRR1013548_SRR1013547","lineage2.2.1","kr","South Korea","pnca_p.leu35pro","A","T","LEU","LA35","pnca_complex.pdb"
|
|
"L35R","L4","PZA","L","L35",35,"R",NA,"Sensitive","OM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",17.42,-0.653,-1.493,-2.11958,-2.016,-0.88,64,80,0.183,4,4,35,0.174129353233831,"loop",1.43333333333333,4.69,0.0025873221216041,0.284614813531639,0.28461481380629,0.284630509244736,2.62510215004498,-30,-32,0,-2,-30,0,0,0,0,-2,0,-2,0,0,0,0,0,-6,0,-6,-2,-2,0,-8,-2,-0.165400202634245,-0.38578811369509,-0.40751749596247,-0.343734015345269,-0.230366492146597,0.673684210526316,0.0586538461538462,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","147/150","G:A:S:M:T:Q:V:L:I",-1.25661854335884,0.0842996990557667,0.727940577686249,-1.72626527752167,0.0461651045270816,0.934717733973448,-0.545742499657136,0.0746087863378038,1.1272100246275,0.033101827382896,1.11162498496942,0.105185735611338,"lineage4","other_mutations_pyrazinamide","ARG",0,"016-1","ERR1750903","lineage4.9","za","","pnca_p.leu35arg","A","T","LEU","LA35","pnca_complex.pdb"
|
|
"L35R","L4","PZA","L","L35",35,"R",NA,"Sensitive","OM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",17.42,-0.653,-1.493,-2.11958,-2.016,-0.88,64,80,0.183,4,4,35,0.174129353233831,"loop",1.43333333333333,4.69,0.0025873221216041,0.284614813531639,0.28461481380629,0.284630509244736,2.62510215004498,-30,-32,0,-2,-30,0,0,0,0,-2,0,-2,0,0,0,0,0,-6,0,-6,-2,-2,0,-8,-2,-0.165400202634245,-0.38578811369509,-0.40751749596247,-0.343734015345269,-0.230366492146597,0.673684210526316,0.0586538461538462,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","147/150","G:A:S:M:T:Q:V:L:I",-1.25661854335884,0.0842996990557667,0.727940577686249,-1.72626527752167,0.0461651045270816,0.934717733973448,-0.545742499657136,0.0746087863378038,1.1272100246275,0.033101827382896,1.11162498496942,0.105185735611338,"lineage4","other_mutations_pyrazinamide","ARG",0,"ERR2200017","ERR2200017","lineage4.9","sz","Swaziland","pnca_p.leu35arg","A","T","LEU","LA35","pnca_complex.pdb"
|
|
"L35R","L4","PZA","L","L35",35,"R",0,"Sensitive","OM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",17.42,-0.653,-1.493,-2.11958,-2.016,-0.88,64,80,0.183,4,4,35,0.174129353233831,"loop",1.43333333333333,4.69,0.0025873221216041,0.284614813531639,0.28461481380629,0.284630509244736,2.62510215004498,-30,-32,0,-2,-30,0,0,0,0,-2,0,-2,0,0,0,0,0,-6,0,-6,-2,-2,0,-8,-2,-0.165400202634245,-0.38578811369509,-0.40751749596247,-0.343734015345269,-0.230366492146597,0.673684210526316,0.0586538461538462,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","147/150","G:A:S:M:T:Q:V:L:I",-1.25661854335884,0.0842996990557667,0.727940577686249,-1.72626527752167,0.0461651045270816,0.934717733973448,-0.545742499657136,0.0746087863378038,1.1272100246275,0.033101827382896,1.11162498496942,0.105185735611338,"lineage4","other_mutations_pyrazinamide","ARG",0,"ERR2515338","ERR2515338","lineage4.9","za","South Africa","pnca_p.leu35arg","A","T","LEU","LA35","pnca_complex.pdb"
|
|
"L35R","L4","PZA","L","L35",35,"R",NA,"Sensitive","OM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",17.42,-0.653,-1.493,-2.11958,-2.016,-0.88,64,80,0.183,4,4,35,0.174129353233831,"loop",1.43333333333333,4.69,0.0025873221216041,0.284614813531639,0.28461481380629,0.284630509244736,2.62510215004498,-30,-32,0,-2,-30,0,0,0,0,-2,0,-2,0,0,0,0,0,-6,0,-6,-2,-2,0,-8,-2,-0.165400202634245,-0.38578811369509,-0.40751749596247,-0.343734015345269,-0.230366492146597,0.673684210526316,0.0586538461538462,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","147/150","G:A:S:M:T:Q:V:L:I",-1.25661854335884,0.0842996990557667,0.727940577686249,-1.72626527752167,0.0461651045270816,0.934717733973448,-0.545742499657136,0.0746087863378038,1.1272100246275,0.033101827382896,1.11162498496942,0.105185735611338,"lineage4","other_mutations_pyrazinamide","ARG",0,"ERR176594","ERR176594","lineage4.9","mw","Malawi","pnca_p.leu35arg","A","T","LEU","LA35","pnca_complex.pdb"
|
|
"L35R","L4","PZA","L","L35",35,"R",NA,"Other","OM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",17.42,-0.653,-1.493,-2.11958,-2.016,-0.88,64,80,0.183,4,4,35,0.174129353233831,"loop",1.43333333333333,4.69,0.0025873221216041,0.284614813531639,0.28461481380629,0.284630509244736,2.62510215004498,-30,-32,0,-2,-30,0,0,0,0,-2,0,-2,0,0,0,0,0,-6,0,-6,-2,-2,0,-8,-2,-0.165400202634245,-0.38578811369509,-0.40751749596247,-0.343734015345269,-0.230366492146597,0.673684210526316,0.0586538461538462,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","147/150","G:A:S:M:T:Q:V:L:I",-1.25661854335884,0.0842996990557667,0.727940577686249,-1.72626527752167,0.0461651045270816,0.934717733973448,-0.545742499657136,0.0746087863378038,1.1272100246275,0.033101827382896,1.11162498496942,0.105185735611338,"lineage4","other_mutations_pyrazinamide","ARG",0,"ERR221595","ERR221595","lineage4.9","mw","Malawi","pnca_p.leu35arg","A","T","LEU","LA35","pnca_complex.pdb"
|
|
"L35R","L4","PZA","L","L35",35,"R",NA,"Sensitive","OM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",17.42,-0.653,-1.493,-2.11958,-2.016,-0.88,64,80,0.183,4,4,35,0.174129353233831,"loop",1.43333333333333,4.69,0.0025873221216041,0.284614813531639,0.28461481380629,0.284630509244736,2.62510215004498,-30,-32,0,-2,-30,0,0,0,0,-2,0,-2,0,0,0,0,0,-6,0,-6,-2,-2,0,-8,-2,-0.165400202634245,-0.38578811369509,-0.40751749596247,-0.343734015345269,-0.230366492146597,0.673684210526316,0.0586538461538462,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","147/150","G:A:S:M:T:Q:V:L:I",-1.25661854335884,0.0842996990557667,0.727940577686249,-1.72626527752167,0.0461651045270816,0.934717733973448,-0.545742499657136,0.0746087863378038,1.1272100246275,0.033101827382896,1.11162498496942,0.105185735611338,"lineage4","other_mutations_pyrazinamide","ARG",0,"ERR176811","ERR176811","lineage4.9","mw","Malawi","pnca_p.leu35arg","A","T","LEU","LA35","pnca_complex.pdb"
|
|
"L35R","L4","PZA","L","L35",35,"R",0,"Sensitive","OM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",17.42,-0.653,-1.493,-2.11958,-2.016,-0.88,64,80,0.183,4,4,35,0.174129353233831,"loop",1.43333333333333,4.69,0.0025873221216041,0.284614813531639,0.28461481380629,0.284630509244736,2.62510215004498,-30,-32,0,-2,-30,0,0,0,0,-2,0,-2,0,0,0,0,0,-6,0,-6,-2,-2,0,-8,-2,-0.165400202634245,-0.38578811369509,-0.40751749596247,-0.343734015345269,-0.230366492146597,0.673684210526316,0.0586538461538462,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","147/150","G:A:S:M:T:Q:V:L:I",-1.25661854335884,0.0842996990557667,0.727940577686249,-1.72626527752167,0.0461651045270816,0.934717733973448,-0.545742499657136,0.0746087863378038,1.1272100246275,0.033101827382896,1.11162498496942,0.105185735611338,"lineage4","other_mutations_pyrazinamide","ARG",0,"SAMN03648800,SRR2101553","SRR2101553","lineage4.9","","","pnca_p.leu35arg","A","T","LEU","LA35","pnca_complex.pdb"
|
|
"L35R","L4","PZA","L","L35",35,"R",NA,"Sensitive","OM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",17.42,-0.653,-1.493,-2.11958,-2.016,-0.88,64,80,0.183,4,4,35,0.174129353233831,"loop",1.43333333333333,4.69,0.0025873221216041,0.284614813531639,0.28461481380629,0.284630509244736,2.62510215004498,-30,-32,0,-2,-30,0,0,0,0,-2,0,-2,0,0,0,0,0,-6,0,-6,-2,-2,0,-8,-2,-0.165400202634245,-0.38578811369509,-0.40751749596247,-0.343734015345269,-0.230366492146597,0.673684210526316,0.0586538461538462,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","147/150","G:A:S:M:T:Q:V:L:I",-1.25661854335884,0.0842996990557667,0.727940577686249,-1.72626527752167,0.0461651045270816,0.934717733973448,-0.545742499657136,0.0746087863378038,1.1272100246275,0.033101827382896,1.11162498496942,0.105185735611338,"lineage4","other_mutations_pyrazinamide","ARG",0,"ERR323076","ERR323076","lineage4.9","mw","Malawi","pnca_p.leu35arg","A","T","LEU","LA35","pnca_complex.pdb"
|
|
"L35R","L4","PZA","L","L35",35,"R",1,"Sensitive","OM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",17.42,-0.653,-1.493,-2.11958,-2.016,-0.88,64,80,0.183,4,4,35,0.174129353233831,"loop",1.43333333333333,4.69,0.0025873221216041,0.284614813531639,0.28461481380629,0.284630509244736,2.62510215004498,-30,-32,0,-2,-30,0,0,0,0,-2,0,-2,0,0,0,0,0,-6,0,-6,-2,-2,0,-8,-2,-0.165400202634245,-0.38578811369509,-0.40751749596247,-0.343734015345269,-0.230366492146597,0.673684210526316,0.0586538461538462,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","147/150","G:A:S:M:T:Q:V:L:I",-1.25661854335884,0.0842996990557667,0.727940577686249,-1.72626527752167,0.0461651045270816,0.934717733973448,-0.545742499657136,0.0746087863378038,1.1272100246275,0.033101827382896,1.11162498496942,0.105185735611338,"lineage4","other_mutations_pyrazinamide","ARG",0,"ERR176598","ERR176598","lineage4.9","mw","Malawi","pnca_p.leu35arg","A","T","LEU","LA35","pnca_complex.pdb"
|
|
"L35R","L4","PZA","L","L35",35,"R",0,"Sensitive","OM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",17.42,-0.653,-1.493,-2.11958,-2.016,-0.88,64,80,0.183,4,4,35,0.174129353233831,"loop",1.43333333333333,4.69,0.0025873221216041,0.284614813531639,0.28461481380629,0.284630509244736,2.62510215004498,-30,-32,0,-2,-30,0,0,0,0,-2,0,-2,0,0,0,0,0,-6,0,-6,-2,-2,0,-8,-2,-0.165400202634245,-0.38578811369509,-0.40751749596247,-0.343734015345269,-0.230366492146597,0.673684210526316,0.0586538461538462,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","147/150","G:A:S:M:T:Q:V:L:I",-1.25661854335884,0.0842996990557667,0.727940577686249,-1.72626527752167,0.0461651045270816,0.934717733973448,-0.545742499657136,0.0746087863378038,1.1272100246275,0.033101827382896,1.11162498496942,0.105185735611338,"lineage4","other_mutations_pyrazinamide","ARG",0,"ERR037517","ERR037517","lineage4.9","mw","Malawi","pnca_p.leu35arg","A","T","LEU","LA35","pnca_complex.pdb"
|
|
"L35R","L4","PZA","L","L35",35,"R",0,"Sensitive","OM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",17.42,-0.653,-1.493,-2.11958,-2.016,-0.88,64,80,0.183,4,4,35,0.174129353233831,"loop",1.43333333333333,4.69,0.0025873221216041,0.284614813531639,0.28461481380629,0.284630509244736,2.62510215004498,-30,-32,0,-2,-30,0,0,0,0,-2,0,-2,0,0,0,0,0,-6,0,-6,-2,-2,0,-8,-2,-0.165400202634245,-0.38578811369509,-0.40751749596247,-0.343734015345269,-0.230366492146597,0.673684210526316,0.0586538461538462,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","147/150","G:A:S:M:T:Q:V:L:I",-1.25661854335884,0.0842996990557667,0.727940577686249,-1.72626527752167,0.0461651045270816,0.934717733973448,-0.545742499657136,0.0746087863378038,1.1272100246275,0.033101827382896,1.11162498496942,0.105185735611338,"lineage4","other_mutations_pyrazinamide","ARG",0,"ERR037509","ERR037509","lineage4.9","mw","Malawi","pnca_p.leu35arg","A","T","LEU","LA35","pnca_complex.pdb"
|
|
"L35R","L4","PZA","L","L35",35,"R",0,"Sensitive","OM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",17.42,-0.653,-1.493,-2.11958,-2.016,-0.88,64,80,0.183,4,4,35,0.174129353233831,"loop",1.43333333333333,4.69,0.0025873221216041,0.284614813531639,0.28461481380629,0.284630509244736,2.62510215004498,-30,-32,0,-2,-30,0,0,0,0,-2,0,-2,0,0,0,0,0,-6,0,-6,-2,-2,0,-8,-2,-0.165400202634245,-0.38578811369509,-0.40751749596247,-0.343734015345269,-0.230366492146597,0.673684210526316,0.0586538461538462,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","147/150","G:A:S:M:T:Q:V:L:I",-1.25661854335884,0.0842996990557667,0.727940577686249,-1.72626527752167,0.0461651045270816,0.934717733973448,-0.545742499657136,0.0746087863378038,1.1272100246275,0.033101827382896,1.11162498496942,0.105185735611338,"lineage4","other_mutations_pyrazinamide","ARG",0,"SRR2100547,SAMN03647720","SRR2100547","lineage4.9","","","pnca_p.leu35arg","A","T","LEU","LA35","pnca_complex.pdb"
|
|
"L35R","L4","PZA","L","L35",35,"R",NA,"Sensitive","OM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",17.42,-0.653,-1.493,-2.11958,-2.016,-0.88,64,80,0.183,4,4,35,0.174129353233831,"loop",1.43333333333333,4.69,0.0025873221216041,0.284614813531639,0.28461481380629,0.284630509244736,2.62510215004498,-30,-32,0,-2,-30,0,0,0,0,-2,0,-2,0,0,0,0,0,-6,0,-6,-2,-2,0,-8,-2,-0.165400202634245,-0.38578811369509,-0.40751749596247,-0.343734015345269,-0.230366492146597,0.673684210526316,0.0586538461538462,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","147/150","G:A:S:M:T:Q:V:L:I",-1.25661854335884,0.0842996990557667,0.727940577686249,-1.72626527752167,0.0461651045270816,0.934717733973448,-0.545742499657136,0.0746087863378038,1.1272100246275,0.033101827382896,1.11162498496942,0.105185735611338,"lineage4","other_mutations_pyrazinamide","ARG",0,"ERR245719","ERR245719","lineage4.9","mw","Malawi","pnca_p.leu35arg","A","T","LEU","LA35","pnca_complex.pdb"
|
|
"L35R","L4","PZA","L","L35",35,"R",NA,"Sensitive","OM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",17.42,-0.653,-1.493,-2.11958,-2.016,-0.88,64,80,0.183,4,4,35,0.174129353233831,"loop",1.43333333333333,4.69,0.0025873221216041,0.284614813531639,0.28461481380629,0.284630509244736,2.62510215004498,-30,-32,0,-2,-30,0,0,0,0,-2,0,-2,0,0,0,0,0,-6,0,-6,-2,-2,0,-8,-2,-0.165400202634245,-0.38578811369509,-0.40751749596247,-0.343734015345269,-0.230366492146597,0.673684210526316,0.0586538461538462,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","147/150","G:A:S:M:T:Q:V:L:I",-1.25661854335884,0.0842996990557667,0.727940577686249,-1.72626527752167,0.0461651045270816,0.934717733973448,-0.545742499657136,0.0746087863378038,1.1272100246275,0.033101827382896,1.11162498496942,0.105185735611338,"lineage4","other_mutations_pyrazinamide","ARG",0,"ERR245712","ERR245712","lineage4.9","mw","Malawi","pnca_p.leu35arg","A","T","LEU","LA35","pnca_complex.pdb"
|
|
"L35R","L4","PZA","L","L35",35,"R",NA,"MDR","OM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",17.42,-0.653,-1.493,-2.11958,-2.016,-0.88,64,80,0.183,4,4,35,0.174129353233831,"loop",1.43333333333333,4.69,0.0025873221216041,0.284614813531639,0.28461481380629,0.284630509244736,2.62510215004498,-30,-32,0,-2,-30,0,0,0,0,-2,0,-2,0,0,0,0,0,-6,0,-6,-2,-2,0,-8,-2,-0.165400202634245,-0.38578811369509,-0.40751749596247,-0.343734015345269,-0.230366492146597,0.673684210526316,0.0586538461538462,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","147/150","G:A:S:M:T:Q:V:L:I",-1.25661854335884,0.0842996990557667,0.727940577686249,-1.72626527752167,0.0461651045270816,0.934717733973448,-0.545742499657136,0.0746087863378038,1.1272100246275,0.033101827382896,1.11162498496942,0.105185735611338,"lineage4","other_mutations_pyrazinamide","ARG",0,"ERR2515520","ERR2515520","lineage4.9","za","South Africa","pnca_p.leu35arg","A","T","LEU","LA35","pnca_complex.pdb"
|
|
"L35R","L4","PZA","L","L35",35,"R",NA,"Sensitive","OM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",17.42,-0.653,-1.493,-2.11958,-2.016,-0.88,64,80,0.183,4,4,35,0.174129353233831,"loop",1.43333333333333,4.69,0.0025873221216041,0.284614813531639,0.28461481380629,0.284630509244736,2.62510215004498,-30,-32,0,-2,-30,0,0,0,0,-2,0,-2,0,0,0,0,0,-6,0,-6,-2,-2,0,-8,-2,-0.165400202634245,-0.38578811369509,-0.40751749596247,-0.343734015345269,-0.230366492146597,0.673684210526316,0.0586538461538462,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","147/150","G:A:S:M:T:Q:V:L:I",-1.25661854335884,0.0842996990557667,0.727940577686249,-1.72626527752167,0.0461651045270816,0.934717733973448,-0.545742499657136,0.0746087863378038,1.1272100246275,0.033101827382896,1.11162498496942,0.105185735611338,"lineage4","other_mutations_pyrazinamide","ARG",0,"ERR037526","ERR037526","lineage4.9","mw","Malawi","pnca_p.leu35arg","A","T","LEU","LA35","pnca_complex.pdb"
|
|
"L35R","L4","PZA","L","L35",35,"R",0,"MDR","OM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",17.42,-0.653,-1.493,-2.11958,-2.016,-0.88,64,80,0.183,4,4,35,0.174129353233831,"loop",1.43333333333333,4.69,0.0025873221216041,0.284614813531639,0.28461481380629,0.284630509244736,2.62510215004498,-30,-32,0,-2,-30,0,0,0,0,-2,0,-2,0,0,0,0,0,-6,0,-6,-2,-2,0,-8,-2,-0.165400202634245,-0.38578811369509,-0.40751749596247,-0.343734015345269,-0.230366492146597,0.673684210526316,0.0586538461538462,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","147/150","G:A:S:M:T:Q:V:L:I",-1.25661854335884,0.0842996990557667,0.727940577686249,-1.72626527752167,0.0461651045270816,0.934717733973448,-0.545742499657136,0.0746087863378038,1.1272100246275,0.033101827382896,1.11162498496942,0.105185735611338,"lineage4","other_mutations_pyrazinamide","ARG",0,"ERR2516695","ERR2516695","lineage4.9","nl","Netherlands","pnca_p.leu35arg","A","T","LEU","LA35","pnca_complex.pdb"
|
|
"L35R","L4","PZA","L","L35",35,"R",NA,"Sensitive","OM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",17.42,-0.653,-1.493,-2.11958,-2.016,-0.88,64,80,0.183,4,4,35,0.174129353233831,"loop",1.43333333333333,4.69,0.0025873221216041,0.284614813531639,0.28461481380629,0.284630509244736,2.62510215004498,-30,-32,0,-2,-30,0,0,0,0,-2,0,-2,0,0,0,0,0,-6,0,-6,-2,-2,0,-8,-2,-0.165400202634245,-0.38578811369509,-0.40751749596247,-0.343734015345269,-0.230366492146597,0.673684210526316,0.0586538461538462,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","147/150","G:A:S:M:T:Q:V:L:I",-1.25661854335884,0.0842996990557667,0.727940577686249,-1.72626527752167,0.0461651045270816,0.934717733973448,-0.545742499657136,0.0746087863378038,1.1272100246275,0.033101827382896,1.11162498496942,0.105185735611338,"lineage4","other_mutations_pyrazinamide","ARG",0,"ERR245653","ERR245653","lineage4.9","mw","Malawi","pnca_p.leu35arg","A","T","LEU","LA35","pnca_complex.pdb"
|
|
"L35R","L4","PZA","L","L35",35,"R",0,"Sensitive","OM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",17.42,-0.653,-1.493,-2.11958,-2.016,-0.88,64,80,0.183,4,4,35,0.174129353233831,"loop",1.43333333333333,4.69,0.0025873221216041,0.284614813531639,0.28461481380629,0.284630509244736,2.62510215004498,-30,-32,0,-2,-30,0,0,0,0,-2,0,-2,0,0,0,0,0,-6,0,-6,-2,-2,0,-8,-2,-0.165400202634245,-0.38578811369509,-0.40751749596247,-0.343734015345269,-0.230366492146597,0.673684210526316,0.0586538461538462,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","147/150","G:A:S:M:T:Q:V:L:I",-1.25661854335884,0.0842996990557667,0.727940577686249,-1.72626527752167,0.0461651045270816,0.934717733973448,-0.545742499657136,0.0746087863378038,1.1272100246275,0.033101827382896,1.11162498496942,0.105185735611338,"lineage4","other_mutations_pyrazinamide","ARG",0,"ERR176762","ERR176762","lineage4.9","mw","Malawi","pnca_p.leu35arg","A","T","LEU","LA35","pnca_complex.pdb"
|
|
"L35R","L4","PZA","L","L35",35,"R",NA,"Sensitive","OM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",17.42,-0.653,-1.493,-2.11958,-2.016,-0.88,64,80,0.183,4,4,35,0.174129353233831,"loop",1.43333333333333,4.69,0.0025873221216041,0.284614813531639,0.28461481380629,0.284630509244736,2.62510215004498,-30,-32,0,-2,-30,0,0,0,0,-2,0,-2,0,0,0,0,0,-6,0,-6,-2,-2,0,-8,-2,-0.165400202634245,-0.38578811369509,-0.40751749596247,-0.343734015345269,-0.230366492146597,0.673684210526316,0.0586538461538462,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","147/150","G:A:S:M:T:Q:V:L:I",-1.25661854335884,0.0842996990557667,0.727940577686249,-1.72626527752167,0.0461651045270816,0.934717733973448,-0.545742499657136,0.0746087863378038,1.1272100246275,0.033101827382896,1.11162498496942,0.105185735611338,"lineage4","other_mutations_pyrazinamide","ARG",0,"016-2","ERR1750904","lineage4.9","za","","pnca_p.leu35arg","A","T","LEU","LA35","pnca_complex.pdb"
|
|
"L35R","L4","PZA","L","L35",35,"R",NA,"Sensitive","OM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",17.42,-0.653,-1.493,-2.11958,-2.016,-0.88,64,80,0.183,4,4,35,0.174129353233831,"loop",1.43333333333333,4.69,0.0025873221216041,0.284614813531639,0.28461481380629,0.284630509244736,2.62510215004498,-30,-32,0,-2,-30,0,0,0,0,-2,0,-2,0,0,0,0,0,-6,0,-6,-2,-2,0,-8,-2,-0.165400202634245,-0.38578811369509,-0.40751749596247,-0.343734015345269,-0.230366492146597,0.673684210526316,0.0586538461538462,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","147/150","G:A:S:M:T:Q:V:L:I",-1.25661854335884,0.0842996990557667,0.727940577686249,-1.72626527752167,0.0461651045270816,0.934717733973448,-0.545742499657136,0.0746087863378038,1.1272100246275,0.033101827382896,1.11162498496942,0.105185735611338,"lineage4","other_mutations_pyrazinamide","ARG",0,"ERR221527","ERR221527","lineage4.9","mw","Malawi","pnca_p.leu35arg","A","T","LEU","LA35","pnca_complex.pdb"
|
|
"L35R","L4","PZA","L","L35",35,"R",NA,"Sensitive","OM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",17.42,-0.653,-1.493,-2.11958,-2.016,-0.88,64,80,0.183,4,4,35,0.174129353233831,"loop",1.43333333333333,4.69,0.0025873221216041,0.284614813531639,0.28461481380629,0.284630509244736,2.62510215004498,-30,-32,0,-2,-30,0,0,0,0,-2,0,-2,0,0,0,0,0,-6,0,-6,-2,-2,0,-8,-2,-0.165400202634245,-0.38578811369509,-0.40751749596247,-0.343734015345269,-0.230366492146597,0.673684210526316,0.0586538461538462,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","147/150","G:A:S:M:T:Q:V:L:I",-1.25661854335884,0.0842996990557667,0.727940577686249,-1.72626527752167,0.0461651045270816,0.934717733973448,-0.545742499657136,0.0746087863378038,1.1272100246275,0.033101827382896,1.11162498496942,0.105185735611338,"lineage4","other_mutations_pyrazinamide","ARG",0,"ERR161196","ERR161196","lineage4.9","mw","Malawi","pnca_p.leu35arg","A","T","LEU","LA35","pnca_complex.pdb"
|
|
"L35R","L4","PZA","L","L35",35,"R",NA,"Sensitive","OM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",17.42,-0.653,-1.493,-2.11958,-2.016,-0.88,64,80,0.183,4,4,35,0.174129353233831,"loop",1.43333333333333,4.69,0.0025873221216041,0.284614813531639,0.28461481380629,0.284630509244736,2.62510215004498,-30,-32,0,-2,-30,0,0,0,0,-2,0,-2,0,0,0,0,0,-6,0,-6,-2,-2,0,-8,-2,-0.165400202634245,-0.38578811369509,-0.40751749596247,-0.343734015345269,-0.230366492146597,0.673684210526316,0.0586538461538462,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","147/150","G:A:S:M:T:Q:V:L:I",-1.25661854335884,0.0842996990557667,0.727940577686249,-1.72626527752167,0.0461651045270816,0.934717733973448,-0.545742499657136,0.0746087863378038,1.1272100246275,0.033101827382896,1.11162498496942,0.105185735611338,"lineage4","other_mutations_pyrazinamide","ARG",0,"ERR245845","ERR245845","lineage4.9","mw","Malawi","pnca_p.leu35arg","A","T","LEU","LA35","pnca_complex.pdb"
|
|
"L35R","L4","PZA","L","L35",35,"R",0,"MDR","OM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",17.42,-0.653,-1.493,-2.11958,-2.016,-0.88,64,80,0.183,4,4,35,0.174129353233831,"loop",1.43333333333333,4.69,0.0025873221216041,0.284614813531639,0.28461481380629,0.284630509244736,2.62510215004498,-30,-32,0,-2,-30,0,0,0,0,-2,0,-2,0,0,0,0,0,-6,0,-6,-2,-2,0,-8,-2,-0.165400202634245,-0.38578811369509,-0.40751749596247,-0.343734015345269,-0.230366492146597,0.673684210526316,0.0586538461538462,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","147/150","G:A:S:M:T:Q:V:L:I",-1.25661854335884,0.0842996990557667,0.727940577686249,-1.72626527752167,0.0461651045270816,0.934717733973448,-0.545742499657136,0.0746087863378038,1.1272100246275,0.033101827382896,1.11162498496942,0.105185735611338,"lineage4","other_mutations_pyrazinamide","ARG",0,"ERR2515225","ERR2515225","lineage4.9","za","South Africa","pnca_p.leu35arg","A","T","LEU","LA35","pnca_complex.pdb"
|
|
"L35R","L4","PZA","L","L35",35,"R",NA,"Sensitive","OM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",17.42,-0.653,-1.493,-2.11958,-2.016,-0.88,64,80,0.183,4,4,35,0.174129353233831,"loop",1.43333333333333,4.69,0.0025873221216041,0.284614813531639,0.28461481380629,0.284630509244736,2.62510215004498,-30,-32,0,-2,-30,0,0,0,0,-2,0,-2,0,0,0,0,0,-6,0,-6,-2,-2,0,-8,-2,-0.165400202634245,-0.38578811369509,-0.40751749596247,-0.343734015345269,-0.230366492146597,0.673684210526316,0.0586538461538462,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","147/150","G:A:S:M:T:Q:V:L:I",-1.25661854335884,0.0842996990557667,0.727940577686249,-1.72626527752167,0.0461651045270816,0.934717733973448,-0.545742499657136,0.0746087863378038,1.1272100246275,0.033101827382896,1.11162498496942,0.105185735611338,"lineage4","other_mutations_pyrazinamide","ARG",0,"ERR126611","ERR126611","lineage4.9","mw","Malawi","pnca_p.leu35arg","A","T","LEU","LA35","pnca_complex.pdb"
|
|
"L35R","L4","PZA","L","L35",35,"R",NA,"Sensitive","OM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",17.42,-0.653,-1.493,-2.11958,-2.016,-0.88,64,80,0.183,4,4,35,0.174129353233831,"loop",1.43333333333333,4.69,0.0025873221216041,0.284614813531639,0.28461481380629,0.284630509244736,2.62510215004498,-30,-32,0,-2,-30,0,0,0,0,-2,0,-2,0,0,0,0,0,-6,0,-6,-2,-2,0,-8,-2,-0.165400202634245,-0.38578811369509,-0.40751749596247,-0.343734015345269,-0.230366492146597,0.673684210526316,0.0586538461538462,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","147/150","G:A:S:M:T:Q:V:L:I",-1.25661854335884,0.0842996990557667,0.727940577686249,-1.72626527752167,0.0461651045270816,0.934717733973448,-0.545742499657136,0.0746087863378038,1.1272100246275,0.033101827382896,1.11162498496942,0.105185735611338,"lineage4","other_mutations_pyrazinamide","ARG",0,"ERR245658","ERR245658","lineage4.9","mw","Malawi","pnca_p.leu35arg","A","T","LEU","LA35","pnca_complex.pdb"
|
|
"L35R","L4","PZA","L","L35",35,"R",0,"Sensitive","OM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",17.42,-0.653,-1.493,-2.11958,-2.016,-0.88,64,80,0.183,4,4,35,0.174129353233831,"loop",1.43333333333333,4.69,0.0025873221216041,0.284614813531639,0.28461481380629,0.284630509244736,2.62510215004498,-30,-32,0,-2,-30,0,0,0,0,-2,0,-2,0,0,0,0,0,-6,0,-6,-2,-2,0,-8,-2,-0.165400202634245,-0.38578811369509,-0.40751749596247,-0.343734015345269,-0.230366492146597,0.673684210526316,0.0586538461538462,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","147/150","G:A:S:M:T:Q:V:L:I",-1.25661854335884,0.0842996990557667,0.727940577686249,-1.72626527752167,0.0461651045270816,0.934717733973448,-0.545742499657136,0.0746087863378038,1.1272100246275,0.033101827382896,1.11162498496942,0.105185735611338,"lineage4","other_mutations_pyrazinamide","ARG",0,"ERR2516030","ERR2516030","lineage4.9","za","South Africa","pnca_p.leu35arg","A","T","LEU","LA35","pnca_complex.pdb"
|
|
"L35R","L4","PZA","L","L35",35,"R",NA,"Sensitive","OM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",17.42,-0.653,-1.493,-2.11958,-2.016,-0.88,64,80,0.183,4,4,35,0.174129353233831,"loop",1.43333333333333,4.69,0.0025873221216041,0.284614813531639,0.28461481380629,0.284630509244736,2.62510215004498,-30,-32,0,-2,-30,0,0,0,0,-2,0,-2,0,0,0,0,0,-6,0,-6,-2,-2,0,-8,-2,-0.165400202634245,-0.38578811369509,-0.40751749596247,-0.343734015345269,-0.230366492146597,0.673684210526316,0.0586538461538462,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","147/150","G:A:S:M:T:Q:V:L:I",-1.25661854335884,0.0842996990557667,0.727940577686249,-1.72626527752167,0.0461651045270816,0.934717733973448,-0.545742499657136,0.0746087863378038,1.1272100246275,0.033101827382896,1.11162498496942,0.105185735611338,"lineage4","other_mutations_pyrazinamide","ARG",0,"ERR245659","ERR245659","lineage4.9","mw","Malawi","pnca_p.leu35arg","A","T","LEU","LA35","pnca_complex.pdb"
|
|
"L35R","L4","PZA","L","L35",35,"R",NA,"Sensitive","OM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",17.42,-0.653,-1.493,-2.11958,-2.016,-0.88,64,80,0.183,4,4,35,0.174129353233831,"loop",1.43333333333333,4.69,0.0025873221216041,0.284614813531639,0.28461481380629,0.284630509244736,2.62510215004498,-30,-32,0,-2,-30,0,0,0,0,-2,0,-2,0,0,0,0,0,-6,0,-6,-2,-2,0,-8,-2,-0.165400202634245,-0.38578811369509,-0.40751749596247,-0.343734015345269,-0.230366492146597,0.673684210526316,0.0586538461538462,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","147/150","G:A:S:M:T:Q:V:L:I",-1.25661854335884,0.0842996990557667,0.727940577686249,-1.72626527752167,0.0461651045270816,0.934717733973448,-0.545742499657136,0.0746087863378038,1.1272100246275,0.033101827382896,1.11162498496942,0.105185735611338,"lineage4","other_mutations_pyrazinamide","ARG",0,"ERR245847","ERR245847","lineage4.9","mw","Malawi","pnca_p.leu35arg","A","T","LEU","LA35","pnca_complex.pdb"
|
|
"L35R","L4","PZA","L","L35",35,"R",0,"Sensitive","OM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",17.42,-0.653,-1.493,-2.11958,-2.016,-0.88,64,80,0.183,4,4,35,0.174129353233831,"loop",1.43333333333333,4.69,0.0025873221216041,0.284614813531639,0.28461481380629,0.284630509244736,2.62510215004498,-30,-32,0,-2,-30,0,0,0,0,-2,0,-2,0,0,0,0,0,-6,0,-6,-2,-2,0,-8,-2,-0.165400202634245,-0.38578811369509,-0.40751749596247,-0.343734015345269,-0.230366492146597,0.673684210526316,0.0586538461538462,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","147/150","G:A:S:M:T:Q:V:L:I",-1.25661854335884,0.0842996990557667,0.727940577686249,-1.72626527752167,0.0461651045270816,0.934717733973448,-0.545742499657136,0.0746087863378038,1.1272100246275,0.033101827382896,1.11162498496942,0.105185735611338,"lineage4","other_mutations_pyrazinamide","ARG",0,"ERR037507","ERR037507","lineage4.9","mw","Malawi","pnca_p.leu35arg","A","T","LEU","LA35","pnca_complex.pdb"
|
|
"L35R","L4","PZA","L","L35",35,"R",NA,"Sensitive","OM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",17.42,-0.653,-1.493,-2.11958,-2.016,-0.88,64,80,0.183,4,4,35,0.174129353233831,"loop",1.43333333333333,4.69,0.0025873221216041,0.284614813531639,0.28461481380629,0.284630509244736,2.62510215004498,-30,-32,0,-2,-30,0,0,0,0,-2,0,-2,0,0,0,0,0,-6,0,-6,-2,-2,0,-8,-2,-0.165400202634245,-0.38578811369509,-0.40751749596247,-0.343734015345269,-0.230366492146597,0.673684210526316,0.0586538461538462,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","147/150","G:A:S:M:T:Q:V:L:I",-1.25661854335884,0.0842996990557667,0.727940577686249,-1.72626527752167,0.0461651045270816,0.934717733973448,-0.545742499657136,0.0746087863378038,1.1272100246275,0.033101827382896,1.11162498496942,0.105185735611338,"lineage4","other_mutations_pyrazinamide","ARG",0,"ERR245714","ERR245714","lineage4.9","mw","Malawi","pnca_p.leu35arg","A","T","LEU","LA35","pnca_complex.pdb"
|
|
"L35R","L4","PZA","L","L35",35,"R",0,"Sensitive","OM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",17.42,-0.653,-1.493,-2.11958,-2.016,-0.88,64,80,0.183,4,4,35,0.174129353233831,"loop",1.43333333333333,4.69,0.0025873221216041,0.284614813531639,0.28461481380629,0.284630509244736,2.62510215004498,-30,-32,0,-2,-30,0,0,0,0,-2,0,-2,0,0,0,0,0,-6,0,-6,-2,-2,0,-8,-2,-0.165400202634245,-0.38578811369509,-0.40751749596247,-0.343734015345269,-0.230366492146597,0.673684210526316,0.0586538461538462,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","147/150","G:A:S:M:T:Q:V:L:I",-1.25661854335884,0.0842996990557667,0.727940577686249,-1.72626527752167,0.0461651045270816,0.934717733973448,-0.545742499657136,0.0746087863378038,1.1272100246275,0.033101827382896,1.11162498496942,0.105185735611338,"lineage4","other_mutations_pyrazinamide","ARG",0,"ERR176756","ERR176756","lineage4.9","mw","Malawi","pnca_p.leu35arg","A","T","LEU","LA35","pnca_complex.pdb"
|
|
"L35R","L4","PZA","L","L35",35,"R",NA,"Sensitive","OM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",17.42,-0.653,-1.493,-2.11958,-2.016,-0.88,64,80,0.183,4,4,35,0.174129353233831,"loop",1.43333333333333,4.69,0.0025873221216041,0.284614813531639,0.28461481380629,0.284630509244736,2.62510215004498,-30,-32,0,-2,-30,0,0,0,0,-2,0,-2,0,0,0,0,0,-6,0,-6,-2,-2,0,-8,-2,-0.165400202634245,-0.38578811369509,-0.40751749596247,-0.343734015345269,-0.230366492146597,0.673684210526316,0.0586538461538462,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","147/150","G:A:S:M:T:Q:V:L:I",-1.25661854335884,0.0842996990557667,0.727940577686249,-1.72626527752167,0.0461651045270816,0.934717733973448,-0.545742499657136,0.0746087863378038,1.1272100246275,0.033101827382896,1.11162498496942,0.105185735611338,"lineage4","other_mutations_pyrazinamide","ARG",0,"ERR181967","ERR181967","lineage4.9","mw","Malawi","pnca_p.leu35arg","A","T","LEU","LA35","pnca_complex.pdb"
|
|
"L35R","L4","PZA","L","L35",35,"R",NA,"Sensitive","OM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",17.42,-0.653,-1.493,-2.11958,-2.016,-0.88,64,80,0.183,4,4,35,0.174129353233831,"loop",1.43333333333333,4.69,0.0025873221216041,0.284614813531639,0.28461481380629,0.284630509244736,2.62510215004498,-30,-32,0,-2,-30,0,0,0,0,-2,0,-2,0,0,0,0,0,-6,0,-6,-2,-2,0,-8,-2,-0.165400202634245,-0.38578811369509,-0.40751749596247,-0.343734015345269,-0.230366492146597,0.673684210526316,0.0586538461538462,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","147/150","G:A:S:M:T:Q:V:L:I",-1.25661854335884,0.0842996990557667,0.727940577686249,-1.72626527752167,0.0461651045270816,0.934717733973448,-0.545742499657136,0.0746087863378038,1.1272100246275,0.033101827382896,1.11162498496942,0.105185735611338,"lineage4","other_mutations_pyrazinamide","ARG",0,"ERR221547","ERR221547","lineage4.9","mw","Malawi","pnca_p.leu35arg","A","T","LEU","LA35","pnca_complex.pdb"
|
|
"L35R","L4","PZA","L","L35",35,"R",0,"Sensitive","OM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",17.42,-0.653,-1.493,-2.11958,-2.016,-0.88,64,80,0.183,4,4,35,0.174129353233831,"loop",1.43333333333333,4.69,0.0025873221216041,0.284614813531639,0.28461481380629,0.284630509244736,2.62510215004498,-30,-32,0,-2,-30,0,0,0,0,-2,0,-2,0,0,0,0,0,-6,0,-6,-2,-2,0,-8,-2,-0.165400202634245,-0.38578811369509,-0.40751749596247,-0.343734015345269,-0.230366492146597,0.673684210526316,0.0586538461538462,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","147/150","G:A:S:M:T:Q:V:L:I",-1.25661854335884,0.0842996990557667,0.727940577686249,-1.72626527752167,0.0461651045270816,0.934717733973448,-0.545742499657136,0.0746087863378038,1.1272100246275,0.033101827382896,1.11162498496942,0.105185735611338,"lineage4","other_mutations_pyrazinamide","ARG",0,"ERR2512392","ERR2512392","lineage4.9","gb","UK","pnca_p.leu35arg","A","T","LEU","LA35","pnca_complex.pdb"
|
|
"L35R","L4","PZA","L","L35",35,"R",NA,"Sensitive","OM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",17.42,-0.653,-1.493,-2.11958,-2.016,-0.88,64,80,0.183,4,4,35,0.174129353233831,"loop",1.43333333333333,4.69,0.0025873221216041,0.284614813531639,0.28461481380629,0.284630509244736,2.62510215004498,-30,-32,0,-2,-30,0,0,0,0,-2,0,-2,0,0,0,0,0,-6,0,-6,-2,-2,0,-8,-2,-0.165400202634245,-0.38578811369509,-0.40751749596247,-0.343734015345269,-0.230366492146597,0.673684210526316,0.0586538461538462,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","147/150","G:A:S:M:T:Q:V:L:I",-1.25661854335884,0.0842996990557667,0.727940577686249,-1.72626527752167,0.0461651045270816,0.934717733973448,-0.545742499657136,0.0746087863378038,1.1272100246275,0.033101827382896,1.11162498496942,0.105185735611338,"lineage4","other_mutations_pyrazinamide","ARG",0,"ERR176538","ERR176538","lineage4.9","mw","Malawi","pnca_p.leu35arg","A","T","LEU","LA35","pnca_complex.pdb"
|
|
"L35R","L4","PZA","L","L35",35,"R",NA,"Sensitive","OM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",17.42,-0.653,-1.493,-2.11958,-2.016,-0.88,64,80,0.183,4,4,35,0.174129353233831,"loop",1.43333333333333,4.69,0.0025873221216041,0.284614813531639,0.28461481380629,0.284630509244736,2.62510215004498,-30,-32,0,-2,-30,0,0,0,0,-2,0,-2,0,0,0,0,0,-6,0,-6,-2,-2,0,-8,-2,-0.165400202634245,-0.38578811369509,-0.40751749596247,-0.343734015345269,-0.230366492146597,0.673684210526316,0.0586538461538462,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","147/150","G:A:S:M:T:Q:V:L:I",-1.25661854335884,0.0842996990557667,0.727940577686249,-1.72626527752167,0.0461651045270816,0.934717733973448,-0.545742499657136,0.0746087863378038,1.1272100246275,0.033101827382896,1.11162498496942,0.105185735611338,"lineage4","other_mutations_pyrazinamide","ARG",0,"ERR190381","ERR190381","lineage4.9","mw","Malawi","pnca_p.leu35arg","A","T","LEU","LA35","pnca_complex.pdb"
|
|
"L35R","L4","PZA","L","L35",35,"R",0,"Sensitive","OM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",17.42,-0.653,-1.493,-2.11958,-2.016,-0.88,64,80,0.183,4,4,35,0.174129353233831,"loop",1.43333333333333,4.69,0.0025873221216041,0.284614813531639,0.28461481380629,0.284630509244736,2.62510215004498,-30,-32,0,-2,-30,0,0,0,0,-2,0,-2,0,0,0,0,0,-6,0,-6,-2,-2,0,-8,-2,-0.165400202634245,-0.38578811369509,-0.40751749596247,-0.343734015345269,-0.230366492146597,0.673684210526316,0.0586538461538462,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","147/150","G:A:S:M:T:Q:V:L:I",-1.25661854335884,0.0842996990557667,0.727940577686249,-1.72626527752167,0.0461651045270816,0.934717733973448,-0.545742499657136,0.0746087863378038,1.1272100246275,0.033101827382896,1.11162498496942,0.105185735611338,"lineage4","other_mutations_pyrazinamide","ARG",0,"SRR2101414,SAMN03648661","SRR2101414","lineage4.9","","","pnca_p.leu35arg","A","T","LEU","LA35","pnca_complex.pdb"
|
|
"L35R","L4","PZA","L","L35",35,"R",0,"Pre-MDR","OM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",17.42,-0.653,-1.493,-2.11958,-2.016,-0.88,64,80,0.183,4,4,35,0.174129353233831,"loop",1.43333333333333,4.69,0.0025873221216041,0.284614813531639,0.28461481380629,0.284630509244736,2.62510215004498,-30,-32,0,-2,-30,0,0,0,0,-2,0,-2,0,0,0,0,0,-6,0,-6,-2,-2,0,-8,-2,-0.165400202634245,-0.38578811369509,-0.40751749596247,-0.343734015345269,-0.230366492146597,0.673684210526316,0.0586538461538462,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","147/150","G:A:S:M:T:Q:V:L:I",-1.25661854335884,0.0842996990557667,0.727940577686249,-1.72626527752167,0.0461651045270816,0.934717733973448,-0.545742499657136,0.0746087863378038,1.1272100246275,0.033101827382896,1.11162498496942,0.105185735611338,"lineage4","other_mutations_pyrazinamide","ARG",0,"ERR2515585","ERR2515585","lineage4.9","za","South Africa","pnca_p.leu35arg","A","T","LEU","LA35","pnca_complex.pdb"
|
|
"L35R","L4","PZA","L","L35",35,"R",NA,"Sensitive","OM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",17.42,-0.653,-1.493,-2.11958,-2.016,-0.88,64,80,0.183,4,4,35,0.174129353233831,"loop",1.43333333333333,4.69,0.0025873221216041,0.284614813531639,0.28461481380629,0.284630509244736,2.62510215004498,-30,-32,0,-2,-30,0,0,0,0,-2,0,-2,0,0,0,0,0,-6,0,-6,-2,-2,0,-8,-2,-0.165400202634245,-0.38578811369509,-0.40751749596247,-0.343734015345269,-0.230366492146597,0.673684210526316,0.0586538461538462,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","147/150","G:A:S:M:T:Q:V:L:I",-1.25661854335884,0.0842996990557667,0.727940577686249,-1.72626527752167,0.0461651045270816,0.934717733973448,-0.545742499657136,0.0746087863378038,1.1272100246275,0.033101827382896,1.11162498496942,0.105185735611338,"lineage4","other_mutations_pyrazinamide","ARG",0,"ERR2200005","ERR2200005","lineage4.9","sz","Swaziland","pnca_p.leu35arg","A","T","LEU","LA35","pnca_complex.pdb"
|
|
"L35R","L2","PZA","L","L35",35,"R",0,"MDR","OM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",17.42,-0.653,-1.493,-2.11958,-2.016,-0.88,64,80,0.183,4,4,35,0.174129353233831,"loop",1.43333333333333,4.69,0.0025873221216041,0.284614813531639,0.28461481380629,0.284630509244736,2.62510215004498,-30,-32,0,-2,-30,0,0,0,0,-2,0,-2,0,0,0,0,0,-6,0,-6,-2,-2,0,-8,-2,-0.165400202634245,-0.38578811369509,-0.40751749596247,-0.343734015345269,-0.230366492146597,0.673684210526316,0.0586538461538462,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","147/150","G:A:S:M:T:Q:V:L:I",-1.25661854335884,0.0842996990557667,0.727940577686249,-1.72626527752167,0.0461651045270816,0.934717733973448,-0.545742499657136,0.0746087863378038,1.1272100246275,0.033101827382896,1.11162498496942,0.105185735611338,"lineage2","other_mutations_pyrazinamide","ARG",0,"SAMN10961343","SRR8651591","lineage2.2.1.1","cn","China:Wenzhou","pnca_p.leu35arg","A","T","LEU","LA35","pnca_complex.pdb"
|
|
"L35R","L4","PZA","L","L35",35,"R",0,"Sensitive","OM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",17.42,-0.653,-1.493,-2.11958,-2.016,-0.88,64,80,0.183,4,4,35,0.174129353233831,"loop",1.43333333333333,4.69,0.0025873221216041,0.284614813531639,0.28461481380629,0.284630509244736,2.62510215004498,-30,-32,0,-2,-30,0,0,0,0,-2,0,-2,0,0,0,0,0,-6,0,-6,-2,-2,0,-8,-2,-0.165400202634245,-0.38578811369509,-0.40751749596247,-0.343734015345269,-0.230366492146597,0.673684210526316,0.0586538461538462,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","147/150","G:A:S:M:T:Q:V:L:I",-1.25661854335884,0.0842996990557667,0.727940577686249,-1.72626527752167,0.0461651045270816,0.934717733973448,-0.545742499657136,0.0746087863378038,1.1272100246275,0.033101827382896,1.11162498496942,0.105185735611338,"lineage4","other_mutations_pyrazinamide","ARG",0,"ERR176804","ERR176804","lineage4.9","mw","Malawi","pnca_p.leu35arg","A","T","LEU","LA35","pnca_complex.pdb"
|
|
"L35R","L4","PZA","L","L35",35,"R",NA,"Sensitive","OM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",17.42,-0.653,-1.493,-2.11958,-2.016,-0.88,64,80,0.183,4,4,35,0.174129353233831,"loop",1.43333333333333,4.69,0.0025873221216041,0.284614813531639,0.28461481380629,0.284630509244736,2.62510215004498,-30,-32,0,-2,-30,0,0,0,0,-2,0,-2,0,0,0,0,0,-6,0,-6,-2,-2,0,-8,-2,-0.165400202634245,-0.38578811369509,-0.40751749596247,-0.343734015345269,-0.230366492146597,0.673684210526316,0.0586538461538462,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","147/150","G:A:S:M:T:Q:V:L:I",-1.25661854335884,0.0842996990557667,0.727940577686249,-1.72626527752167,0.0461651045270816,0.934717733973448,-0.545742499657136,0.0746087863378038,1.1272100246275,0.033101827382896,1.11162498496942,0.105185735611338,"lineage4","other_mutations_pyrazinamide","ARG",0,"ERR190392","ERR190392","lineage4.9","mw","Malawi","pnca_p.leu35arg","A","T","LEU","LA35","pnca_complex.pdb"
|
|
"L35R","L4","PZA","L","L35",35,"R",NA,"Sensitive","OM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",17.42,-0.653,-1.493,-2.11958,-2.016,-0.88,64,80,0.183,4,4,35,0.174129353233831,"loop",1.43333333333333,4.69,0.0025873221216041,0.284614813531639,0.28461481380629,0.284630509244736,2.62510215004498,-30,-32,0,-2,-30,0,0,0,0,-2,0,-2,0,0,0,0,0,-6,0,-6,-2,-2,0,-8,-2,-0.165400202634245,-0.38578811369509,-0.40751749596247,-0.343734015345269,-0.230366492146597,0.673684210526316,0.0586538461538462,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","147/150","G:A:S:M:T:Q:V:L:I",-1.25661854335884,0.0842996990557667,0.727940577686249,-1.72626527752167,0.0461651045270816,0.934717733973448,-0.545742499657136,0.0746087863378038,1.1272100246275,0.033101827382896,1.11162498496942,0.105185735611338,"lineage4","other_mutations_pyrazinamide","ARG",0,"ERR161042","ERR161042","lineage4.9","mw","Malawi","pnca_p.leu35arg","A","T","LEU","LA35","pnca_complex.pdb"
|
|
"L35R","L4","PZA","L","L35",35,"R",0,"Sensitive","OM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",17.42,-0.653,-1.493,-2.11958,-2.016,-0.88,64,80,0.183,4,4,35,0.174129353233831,"loop",1.43333333333333,4.69,0.0025873221216041,0.284614813531639,0.28461481380629,0.284630509244736,2.62510215004498,-30,-32,0,-2,-30,0,0,0,0,-2,0,-2,0,0,0,0,0,-6,0,-6,-2,-2,0,-8,-2,-0.165400202634245,-0.38578811369509,-0.40751749596247,-0.343734015345269,-0.230366492146597,0.673684210526316,0.0586538461538462,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","147/150","G:A:S:M:T:Q:V:L:I",-1.25661854335884,0.0842996990557667,0.727940577686249,-1.72626527752167,0.0461651045270816,0.934717733973448,-0.545742499657136,0.0746087863378038,1.1272100246275,0.033101827382896,1.11162498496942,0.105185735611338,"lineage4","other_mutations_pyrazinamide","ARG",0,"ERR037504","ERR037504","lineage4.9","mw","Malawi","pnca_p.leu35arg","A","T","LEU","LA35","pnca_complex.pdb"
|
|
"L35R","L4","PZA","L","L35",35,"R",0,"Other","OM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",17.42,-0.653,-1.493,-2.11958,-2.016,-0.88,64,80,0.183,4,4,35,0.174129353233831,"loop",1.43333333333333,4.69,0.0025873221216041,0.284614813531639,0.28461481380629,0.284630509244736,2.62510215004498,-30,-32,0,-2,-30,0,0,0,0,-2,0,-2,0,0,0,0,0,-6,0,-6,-2,-2,0,-8,-2,-0.165400202634245,-0.38578811369509,-0.40751749596247,-0.343734015345269,-0.230366492146597,0.673684210526316,0.0586538461538462,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","147/150","G:A:S:M:T:Q:V:L:I",-1.25661854335884,0.0842996990557667,0.727940577686249,-1.72626527752167,0.0461651045270816,0.934717733973448,-0.545742499657136,0.0746087863378038,1.1272100246275,0.033101827382896,1.11162498496942,0.105185735611338,"lineage4","other_mutations_pyrazinamide","ARG",0,"ERR176608","ERR176608","lineage4.9","mw","Malawi","pnca_p.leu35arg","A","T","LEU","LA35","pnca_complex.pdb"
|
|
"L35R","L4","PZA","L","L35",35,"R",0,"Sensitive","OM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",17.42,-0.653,-1.493,-2.11958,-2.016,-0.88,64,80,0.183,4,4,35,0.174129353233831,"loop",1.43333333333333,4.69,0.0025873221216041,0.284614813531639,0.28461481380629,0.284630509244736,2.62510215004498,-30,-32,0,-2,-30,0,0,0,0,-2,0,-2,0,0,0,0,0,-6,0,-6,-2,-2,0,-8,-2,-0.165400202634245,-0.38578811369509,-0.40751749596247,-0.343734015345269,-0.230366492146597,0.673684210526316,0.0586538461538462,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","147/150","G:A:S:M:T:Q:V:L:I",-1.25661854335884,0.0842996990557667,0.727940577686249,-1.72626527752167,0.0461651045270816,0.934717733973448,-0.545742499657136,0.0746087863378038,1.1272100246275,0.033101827382896,1.11162498496942,0.105185735611338,"lineage4","other_mutations_pyrazinamide","ARG",0,"ERR164007","ERR164007","lineage4.9","mw","Malawi","pnca_p.leu35arg","A","T","LEU","LA35","pnca_complex.pdb"
|
|
"L35R","L4","PZA","L","L35",35,"R",0,"Sensitive","OM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",17.42,-0.653,-1.493,-2.11958,-2.016,-0.88,64,80,0.183,4,4,35,0.174129353233831,"loop",1.43333333333333,4.69,0.0025873221216041,0.284614813531639,0.28461481380629,0.284630509244736,2.62510215004498,-30,-32,0,-2,-30,0,0,0,0,-2,0,-2,0,0,0,0,0,-6,0,-6,-2,-2,0,-8,-2,-0.165400202634245,-0.38578811369509,-0.40751749596247,-0.343734015345269,-0.230366492146597,0.673684210526316,0.0586538461538462,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","147/150","G:A:S:M:T:Q:V:L:I",-1.25661854335884,0.0842996990557667,0.727940577686249,-1.72626527752167,0.0461651045270816,0.934717733973448,-0.545742499657136,0.0746087863378038,1.1272100246275,0.033101827382896,1.11162498496942,0.105185735611338,"lineage4","other_mutations_pyrazinamide","ARG",0,"ERR176625","ERR176625","lineage4.9","mw","Malawi","pnca_p.leu35arg","A","T","LEU","LA35","pnca_complex.pdb"
|
|
"L35R","L4","PZA","L","L35",35,"R",NA,"Sensitive","OM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",17.42,-0.653,-1.493,-2.11958,-2.016,-0.88,64,80,0.183,4,4,35,0.174129353233831,"loop",1.43333333333333,4.69,0.0025873221216041,0.284614813531639,0.28461481380629,0.284630509244736,2.62510215004498,-30,-32,0,-2,-30,0,0,0,0,-2,0,-2,0,0,0,0,0,-6,0,-6,-2,-2,0,-8,-2,-0.165400202634245,-0.38578811369509,-0.40751749596247,-0.343734015345269,-0.230366492146597,0.673684210526316,0.0586538461538462,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","147/150","G:A:S:M:T:Q:V:L:I",-1.25661854335884,0.0842996990557667,0.727940577686249,-1.72626527752167,0.0461651045270816,0.934717733973448,-0.545742499657136,0.0746087863378038,1.1272100246275,0.033101827382896,1.11162498496942,0.105185735611338,"lineage4","other_mutations_pyrazinamide","ARG",0,"ERR245835","ERR245835","lineage4.9","mw","Malawi","pnca_p.leu35arg","A","T","LEU","LA35","pnca_complex.pdb"
|
|
"L35R","L4","PZA","L","L35",35,"R",1,"MDR","OM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",17.42,-0.653,-1.493,-2.11958,-2.016,-0.88,64,80,0.183,4,4,35,0.174129353233831,"loop",1.43333333333333,4.69,0.0025873221216041,0.284614813531639,0.28461481380629,0.284630509244736,2.62510215004498,-30,-32,0,-2,-30,0,0,0,0,-2,0,-2,0,0,0,0,0,-6,0,-6,-2,-2,0,-8,-2,-0.165400202634245,-0.38578811369509,-0.40751749596247,-0.343734015345269,-0.230366492146597,0.673684210526316,0.0586538461538462,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","147/150","G:A:S:M:T:Q:V:L:I",-1.25661854335884,0.0842996990557667,0.727940577686249,-1.72626527752167,0.0461651045270816,0.934717733973448,-0.545742499657136,0.0746087863378038,1.1272100246275,0.033101827382896,1.11162498496942,0.105185735611338,"lineage4","other_mutations_pyrazinamide","ARG",0,"ERR1036275","ERR1036275","lineage4.3.4.1","pt","Portugal","pnca_p.leu35arg","A","T","LEU","LA35","pnca_complex.pdb"
|
|
"L35R","L4","PZA","L","L35",35,"R",0,"Sensitive","OM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",17.42,-0.653,-1.493,-2.11958,-2.016,-0.88,64,80,0.183,4,4,35,0.174129353233831,"loop",1.43333333333333,4.69,0.0025873221216041,0.284614813531639,0.28461481380629,0.284630509244736,2.62510215004498,-30,-32,0,-2,-30,0,0,0,0,-2,0,-2,0,0,0,0,0,-6,0,-6,-2,-2,0,-8,-2,-0.165400202634245,-0.38578811369509,-0.40751749596247,-0.343734015345269,-0.230366492146597,0.673684210526316,0.0586538461538462,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","147/150","G:A:S:M:T:Q:V:L:I",-1.25661854335884,0.0842996990557667,0.727940577686249,-1.72626527752167,0.0461651045270816,0.934717733973448,-0.545742499657136,0.0746087863378038,1.1272100246275,0.033101827382896,1.11162498496942,0.105185735611338,"lineage4","other_mutations_pyrazinamide","ARG",0,"ERR176733","ERR176733","lineage4.9","mw","Malawi","pnca_p.leu35arg","A","T","LEU","LA35","pnca_complex.pdb"
|
|
"L35R","L4","PZA","L","L35",35,"R",0,"Sensitive","OM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",17.42,-0.653,-1.493,-2.11958,-2.016,-0.88,64,80,0.183,4,4,35,0.174129353233831,"loop",1.43333333333333,4.69,0.0025873221216041,0.284614813531639,0.28461481380629,0.284630509244736,2.62510215004498,-30,-32,0,-2,-30,0,0,0,0,-2,0,-2,0,0,0,0,0,-6,0,-6,-2,-2,0,-8,-2,-0.165400202634245,-0.38578811369509,-0.40751749596247,-0.343734015345269,-0.230366492146597,0.673684210526316,0.0586538461538462,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","147/150","G:A:S:M:T:Q:V:L:I",-1.25661854335884,0.0842996990557667,0.727940577686249,-1.72626527752167,0.0461651045270816,0.934717733973448,-0.545742499657136,0.0746087863378038,1.1272100246275,0.033101827382896,1.11162498496942,0.105185735611338,"lineage4","other_mutations_pyrazinamide","ARG",0,"SAMN03647612,SRR2100439","SRR2100439","lineage4.9","","","pnca_p.leu35arg","A","T","LEU","LA35","pnca_complex.pdb"
|
|
"L35R","L4","PZA","L","L35",35,"R",NA,"Sensitive","OM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",17.42,-0.653,-1.493,-2.11958,-2.016,-0.88,64,80,0.183,4,4,35,0.174129353233831,"loop",1.43333333333333,4.69,0.0025873221216041,0.284614813531639,0.28461481380629,0.284630509244736,2.62510215004498,-30,-32,0,-2,-30,0,0,0,0,-2,0,-2,0,0,0,0,0,-6,0,-6,-2,-2,0,-8,-2,-0.165400202634245,-0.38578811369509,-0.40751749596247,-0.343734015345269,-0.230366492146597,0.673684210526316,0.0586538461538462,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","147/150","G:A:S:M:T:Q:V:L:I",-1.25661854335884,0.0842996990557667,0.727940577686249,-1.72626527752167,0.0461651045270816,0.934717733973448,-0.545742499657136,0.0746087863378038,1.1272100246275,0.033101827382896,1.11162498496942,0.105185735611338,"lineage4","other_mutations_pyrazinamide","ARG",0,"ERR126635","ERR126635","lineage4.9","mw","Malawi","pnca_p.leu35arg","A","T","LEU","LA35","pnca_complex.pdb"
|
|
"L35R","L4","PZA","L","L35",35,"R",0,"Sensitive","OM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",17.42,-0.653,-1.493,-2.11958,-2.016,-0.88,64,80,0.183,4,4,35,0.174129353233831,"loop",1.43333333333333,4.69,0.0025873221216041,0.284614813531639,0.28461481380629,0.284630509244736,2.62510215004498,-30,-32,0,-2,-30,0,0,0,0,-2,0,-2,0,0,0,0,0,-6,0,-6,-2,-2,0,-8,-2,-0.165400202634245,-0.38578811369509,-0.40751749596247,-0.343734015345269,-0.230366492146597,0.673684210526316,0.0586538461538462,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","147/150","G:A:S:M:T:Q:V:L:I",-1.25661854335884,0.0842996990557667,0.727940577686249,-1.72626527752167,0.0461651045270816,0.934717733973448,-0.545742499657136,0.0746087863378038,1.1272100246275,0.033101827382896,1.11162498496942,0.105185735611338,"lineage4","other_mutations_pyrazinamide","ARG",0,"ERR036219","ERR036219","lineage4.9","mw","Malawi","pnca_p.leu35arg","A","T","LEU","LA35","pnca_complex.pdb"
|
|
"L35R","L4","PZA","L","L35",35,"R",NA,"Sensitive","OM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",17.42,-0.653,-1.493,-2.11958,-2.016,-0.88,64,80,0.183,4,4,35,0.174129353233831,"loop",1.43333333333333,4.69,0.0025873221216041,0.284614813531639,0.28461481380629,0.284630509244736,2.62510215004498,-30,-32,0,-2,-30,0,0,0,0,-2,0,-2,0,0,0,0,0,-6,0,-6,-2,-2,0,-8,-2,-0.165400202634245,-0.38578811369509,-0.40751749596247,-0.343734015345269,-0.230366492146597,0.673684210526316,0.0586538461538462,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","147/150","G:A:S:M:T:Q:V:L:I",-1.25661854335884,0.0842996990557667,0.727940577686249,-1.72626527752167,0.0461651045270816,0.934717733973448,-0.545742499657136,0.0746087863378038,1.1272100246275,0.033101827382896,1.11162498496942,0.105185735611338,"lineage4","other_mutations_pyrazinamide","ARG",0,"ERR245650","ERR245650","lineage4.9","mw","Malawi","pnca_p.leu35arg","A","T","LEU","LA35","pnca_complex.pdb"
|
|
"L35R","L4","PZA","L","L35",35,"R",NA,"Sensitive","OM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",17.42,-0.653,-1.493,-2.11958,-2.016,-0.88,64,80,0.183,4,4,35,0.174129353233831,"loop",1.43333333333333,4.69,0.0025873221216041,0.284614813531639,0.28461481380629,0.284630509244736,2.62510215004498,-30,-32,0,-2,-30,0,0,0,0,-2,0,-2,0,0,0,0,0,-6,0,-6,-2,-2,0,-8,-2,-0.165400202634245,-0.38578811369509,-0.40751749596247,-0.343734015345269,-0.230366492146597,0.673684210526316,0.0586538461538462,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","147/150","G:A:S:M:T:Q:V:L:I",-1.25661854335884,0.0842996990557667,0.727940577686249,-1.72626527752167,0.0461651045270816,0.934717733973448,-0.545742499657136,0.0746087863378038,1.1272100246275,0.033101827382896,1.11162498496942,0.105185735611338,"lineage4","other_mutations_pyrazinamide","ARG",0,"ERR161171","ERR161171","lineage4.9","mw","Malawi","pnca_p.leu35arg","A","T","LEU","LA35","pnca_complex.pdb"
|
|
"L35R","L4","PZA","L","L35",35,"R",NA,"Sensitive","OM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",17.42,-0.653,-1.493,-2.11958,-2.016,-0.88,64,80,0.183,4,4,35,0.174129353233831,"loop",1.43333333333333,4.69,0.0025873221216041,0.284614813531639,0.28461481380629,0.284630509244736,2.62510215004498,-30,-32,0,-2,-30,0,0,0,0,-2,0,-2,0,0,0,0,0,-6,0,-6,-2,-2,0,-8,-2,-0.165400202634245,-0.38578811369509,-0.40751749596247,-0.343734015345269,-0.230366492146597,0.673684210526316,0.0586538461538462,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","147/150","G:A:S:M:T:Q:V:L:I",-1.25661854335884,0.0842996990557667,0.727940577686249,-1.72626527752167,0.0461651045270816,0.934717733973448,-0.545742499657136,0.0746087863378038,1.1272100246275,0.033101827382896,1.11162498496942,0.105185735611338,"lineage4","other_mutations_pyrazinamide","ARG",0,"ERR245685","ERR245685","lineage4.9","mw","Malawi","pnca_p.leu35arg","A","T","LEU","LA35","pnca_complex.pdb"
|
|
"L35R","L4","PZA","L","L35",35,"R",NA,"Sensitive","OM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",17.42,-0.653,-1.493,-2.11958,-2.016,-0.88,64,80,0.183,4,4,35,0.174129353233831,"loop",1.43333333333333,4.69,0.0025873221216041,0.284614813531639,0.28461481380629,0.284630509244736,2.62510215004498,-30,-32,0,-2,-30,0,0,0,0,-2,0,-2,0,0,0,0,0,-6,0,-6,-2,-2,0,-8,-2,-0.165400202634245,-0.38578811369509,-0.40751749596247,-0.343734015345269,-0.230366492146597,0.673684210526316,0.0586538461538462,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","147/150","G:A:S:M:T:Q:V:L:I",-1.25661854335884,0.0842996990557667,0.727940577686249,-1.72626527752167,0.0461651045270816,0.934717733973448,-0.545742499657136,0.0746087863378038,1.1272100246275,0.033101827382896,1.11162498496942,0.105185735611338,"lineage4","other_mutations_pyrazinamide","ARG",0,"ERR190396","ERR190396","lineage4.9","mw","Malawi","pnca_p.leu35arg","A","T","LEU","LA35","pnca_complex.pdb"
|
|
"L35R","L4","PZA","L","L35",35,"R",0,"Sensitive","OM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",17.42,-0.653,-1.493,-2.11958,-2.016,-0.88,64,80,0.183,4,4,35,0.174129353233831,"loop",1.43333333333333,4.69,0.0025873221216041,0.284614813531639,0.28461481380629,0.284630509244736,2.62510215004498,-30,-32,0,-2,-30,0,0,0,0,-2,0,-2,0,0,0,0,0,-6,0,-6,-2,-2,0,-8,-2,-0.165400202634245,-0.38578811369509,-0.40751749596247,-0.343734015345269,-0.230366492146597,0.673684210526316,0.0586538461538462,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","147/150","G:A:S:M:T:Q:V:L:I",-1.25661854335884,0.0842996990557667,0.727940577686249,-1.72626527752167,0.0461651045270816,0.934717733973448,-0.545742499657136,0.0746087863378038,1.1272100246275,0.033101827382896,1.11162498496942,0.105185735611338,"lineage4","other_mutations_pyrazinamide","ARG",0,"SRR2101449,SAMN03648696","SRR2101449","lineage4.9","","","pnca_p.leu35arg","A","T","LEU","LA35","pnca_complex.pdb"
|
|
"L35R","L4","PZA","L","L35",35,"R",NA,"Sensitive","OM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",17.42,-0.653,-1.493,-2.11958,-2.016,-0.88,64,80,0.183,4,4,35,0.174129353233831,"loop",1.43333333333333,4.69,0.0025873221216041,0.284614813531639,0.28461481380629,0.284630509244736,2.62510215004498,-30,-32,0,-2,-30,0,0,0,0,-2,0,-2,0,0,0,0,0,-6,0,-6,-2,-2,0,-8,-2,-0.165400202634245,-0.38578811369509,-0.40751749596247,-0.343734015345269,-0.230366492146597,0.673684210526316,0.0586538461538462,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","147/150","G:A:S:M:T:Q:V:L:I",-1.25661854335884,0.0842996990557667,0.727940577686249,-1.72626527752167,0.0461651045270816,0.934717733973448,-0.545742499657136,0.0746087863378038,1.1272100246275,0.033101827382896,1.11162498496942,0.105185735611338,"lineage4","other_mutations_pyrazinamide","ARG",0,"ERR181901","ERR181901","lineage4.9","mw","Malawi","pnca_p.leu35arg","A","T","LEU","LA35","pnca_complex.pdb"
|
|
"L35R","L4","PZA","L","L35",35,"R",0,"Sensitive","OM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",17.42,-0.653,-1.493,-2.11958,-2.016,-0.88,64,80,0.183,4,4,35,0.174129353233831,"loop",1.43333333333333,4.69,0.0025873221216041,0.284614813531639,0.28461481380629,0.284630509244736,2.62510215004498,-30,-32,0,-2,-30,0,0,0,0,-2,0,-2,0,0,0,0,0,-6,0,-6,-2,-2,0,-8,-2,-0.165400202634245,-0.38578811369509,-0.40751749596247,-0.343734015345269,-0.230366492146597,0.673684210526316,0.0586538461538462,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","147/150","G:A:S:M:T:Q:V:L:I",-1.25661854335884,0.0842996990557667,0.727940577686249,-1.72626527752167,0.0461651045270816,0.934717733973448,-0.545742499657136,0.0746087863378038,1.1272100246275,0.033101827382896,1.11162498496942,0.105185735611338,"lineage4","other_mutations_pyrazinamide","ARG",0,"ERR2515967","ERR2515967","lineage4.9","za","South Africa","pnca_p.leu35arg","A","T","LEU","LA35","pnca_complex.pdb"
|
|
"L35R","L4","PZA","L","L35",35,"R",0,"Sensitive","OM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",17.42,-0.653,-1.493,-2.11958,-2.016,-0.88,64,80,0.183,4,4,35,0.174129353233831,"loop",1.43333333333333,4.69,0.0025873221216041,0.284614813531639,0.28461481380629,0.284630509244736,2.62510215004498,-30,-32,0,-2,-30,0,0,0,0,-2,0,-2,0,0,0,0,0,-6,0,-6,-2,-2,0,-8,-2,-0.165400202634245,-0.38578811369509,-0.40751749596247,-0.343734015345269,-0.230366492146597,0.673684210526316,0.0586538461538462,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","147/150","G:A:S:M:T:Q:V:L:I",-1.25661854335884,0.0842996990557667,0.727940577686249,-1.72626527752167,0.0461651045270816,0.934717733973448,-0.545742499657136,0.0746087863378038,1.1272100246275,0.033101827382896,1.11162498496942,0.105185735611338,"lineage4","other_mutations_pyrazinamide","ARG",0,"SRR2101609,SAMN03648856","SRR2101609","lineage4.9","","","pnca_p.leu35arg","A","T","LEU","LA35","pnca_complex.pdb"
|
|
"L35R","L4","PZA","L","L35",35,"R",NA,"Sensitive","OM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",17.42,-0.653,-1.493,-2.11958,-2.016,-0.88,64,80,0.183,4,4,35,0.174129353233831,"loop",1.43333333333333,4.69,0.0025873221216041,0.284614813531639,0.28461481380629,0.284630509244736,2.62510215004498,-30,-32,0,-2,-30,0,0,0,0,-2,0,-2,0,0,0,0,0,-6,0,-6,-2,-2,0,-8,-2,-0.165400202634245,-0.38578811369509,-0.40751749596247,-0.343734015345269,-0.230366492146597,0.673684210526316,0.0586538461538462,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","147/150","G:A:S:M:T:Q:V:L:I",-1.25661854335884,0.0842996990557667,0.727940577686249,-1.72626527752167,0.0461651045270816,0.934717733973448,-0.545742499657136,0.0746087863378038,1.1272100246275,0.033101827382896,1.11162498496942,0.105185735611338,"lineage4","other_mutations_pyrazinamide","ARG",0,"ERR245772","ERR245772","lineage4.9","mw","Malawi","pnca_p.leu35arg","A","T","LEU","LA35","pnca_complex.pdb"
|
|
"L35R","L4","PZA","L","L35",35,"R",0,"Sensitive","OM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",17.42,-0.653,-1.493,-2.11958,-2.016,-0.88,64,80,0.183,4,4,35,0.174129353233831,"loop",1.43333333333333,4.69,0.0025873221216041,0.284614813531639,0.28461481380629,0.284630509244736,2.62510215004498,-30,-32,0,-2,-30,0,0,0,0,-2,0,-2,0,0,0,0,0,-6,0,-6,-2,-2,0,-8,-2,-0.165400202634245,-0.38578811369509,-0.40751749596247,-0.343734015345269,-0.230366492146597,0.673684210526316,0.0586538461538462,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","147/150","G:A:S:M:T:Q:V:L:I",-1.25661854335884,0.0842996990557667,0.727940577686249,-1.72626527752167,0.0461651045270816,0.934717733973448,-0.545742499657136,0.0746087863378038,1.1272100246275,0.033101827382896,1.11162498496942,0.105185735611338,"lineage4","other_mutations_pyrazinamide","ARG",0,"ERR2515120","ERR2515120","lineage4.9","za","South Africa","pnca_p.leu35arg","A","T","LEU","LA35","pnca_complex.pdb"
|
|
"L35R","L4","PZA","L","L35",35,"R",NA,"Sensitive","OM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",17.42,-0.653,-1.493,-2.11958,-2.016,-0.88,64,80,0.183,4,4,35,0.174129353233831,"loop",1.43333333333333,4.69,0.0025873221216041,0.284614813531639,0.28461481380629,0.284630509244736,2.62510215004498,-30,-32,0,-2,-30,0,0,0,0,-2,0,-2,0,0,0,0,0,-6,0,-6,-2,-2,0,-8,-2,-0.165400202634245,-0.38578811369509,-0.40751749596247,-0.343734015345269,-0.230366492146597,0.673684210526316,0.0586538461538462,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","147/150","G:A:S:M:T:Q:V:L:I",-1.25661854335884,0.0842996990557667,0.727940577686249,-1.72626527752167,0.0461651045270816,0.934717733973448,-0.545742499657136,0.0746087863378038,1.1272100246275,0.033101827382896,1.11162498496942,0.105185735611338,"lineage4","other_mutations_pyrazinamide","ARG",0,"ERR245731","ERR245731","lineage4.9","mw","Malawi","pnca_p.leu35arg","A","T","LEU","LA35","pnca_complex.pdb"
|
|
"L35R","L4","PZA","L","L35",35,"R",NA,"Sensitive","OM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",17.42,-0.653,-1.493,-2.11958,-2.016,-0.88,64,80,0.183,4,4,35,0.174129353233831,"loop",1.43333333333333,4.69,0.0025873221216041,0.284614813531639,0.28461481380629,0.284630509244736,2.62510215004498,-30,-32,0,-2,-30,0,0,0,0,-2,0,-2,0,0,0,0,0,-6,0,-6,-2,-2,0,-8,-2,-0.165400202634245,-0.38578811369509,-0.40751749596247,-0.343734015345269,-0.230366492146597,0.673684210526316,0.0586538461538462,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","147/150","G:A:S:M:T:Q:V:L:I",-1.25661854335884,0.0842996990557667,0.727940577686249,-1.72626527752167,0.0461651045270816,0.934717733973448,-0.545742499657136,0.0746087863378038,1.1272100246275,0.033101827382896,1.11162498496942,0.105185735611338,"lineage4","other_mutations_pyrazinamide","ARG",0,"SRR6153116","SRR6153116","lineage4.9","ca","Canada","pnca_p.leu35arg","A","T","LEU","LA35","pnca_complex.pdb"
|
|
"L35R","L4","PZA","L","L35",35,"R",NA,"Sensitive","OM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",17.42,-0.653,-1.493,-2.11958,-2.016,-0.88,64,80,0.183,4,4,35,0.174129353233831,"loop",1.43333333333333,4.69,0.0025873221216041,0.284614813531639,0.28461481380629,0.284630509244736,2.62510215004498,-30,-32,0,-2,-30,0,0,0,0,-2,0,-2,0,0,0,0,0,-6,0,-6,-2,-2,0,-8,-2,-0.165400202634245,-0.38578811369509,-0.40751749596247,-0.343734015345269,-0.230366492146597,0.673684210526316,0.0586538461538462,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","147/150","G:A:S:M:T:Q:V:L:I",-1.25661854335884,0.0842996990557667,0.727940577686249,-1.72626527752167,0.0461651045270816,0.934717733973448,-0.545742499657136,0.0746087863378038,1.1272100246275,0.033101827382896,1.11162498496942,0.105185735611338,"lineage4","other_mutations_pyrazinamide","ARG",0,"ERR176529","ERR176529","lineage4.9","mw","Malawi","pnca_p.leu35arg","A","T","LEU","LA35","pnca_complex.pdb"
|
|
"L35R","L4","PZA","L","L35",35,"R",NA,"Sensitive","OM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",17.42,-0.653,-1.493,-2.11958,-2.016,-0.88,64,80,0.183,4,4,35,0.174129353233831,"loop",1.43333333333333,4.69,0.0025873221216041,0.284614813531639,0.28461481380629,0.284630509244736,2.62510215004498,-30,-32,0,-2,-30,0,0,0,0,-2,0,-2,0,0,0,0,0,-6,0,-6,-2,-2,0,-8,-2,-0.165400202634245,-0.38578811369509,-0.40751749596247,-0.343734015345269,-0.230366492146597,0.673684210526316,0.0586538461538462,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","147/150","G:A:S:M:T:Q:V:L:I",-1.25661854335884,0.0842996990557667,0.727940577686249,-1.72626527752167,0.0461651045270816,0.934717733973448,-0.545742499657136,0.0746087863378038,1.1272100246275,0.033101827382896,1.11162498496942,0.105185735611338,"lineage4","other_mutations_pyrazinamide","ARG",0,"ERR245810","ERR245810","lineage4.9","mw","","pnca_p.leu35arg","A","T","LEU","LA35","pnca_complex.pdb"
|
|
"L35R","L4","PZA","L","L35",35,"R",NA,"Sensitive","OM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",17.42,-0.653,-1.493,-2.11958,-2.016,-0.88,64,80,0.183,4,4,35,0.174129353233831,"loop",1.43333333333333,4.69,0.0025873221216041,0.284614813531639,0.28461481380629,0.284630509244736,2.62510215004498,-30,-32,0,-2,-30,0,0,0,0,-2,0,-2,0,0,0,0,0,-6,0,-6,-2,-2,0,-8,-2,-0.165400202634245,-0.38578811369509,-0.40751749596247,-0.343734015345269,-0.230366492146597,0.673684210526316,0.0586538461538462,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","147/150","G:A:S:M:T:Q:V:L:I",-1.25661854335884,0.0842996990557667,0.727940577686249,-1.72626527752167,0.0461651045270816,0.934717733973448,-0.545742499657136,0.0746087863378038,1.1272100246275,0.033101827382896,1.11162498496942,0.105185735611338,"lineage4","other_mutations_pyrazinamide","ARG",0,"ERR1034946","ERR1034946","lineage4.9","za","South Africa","pnca_p.leu35arg","A","T","LEU","LA35","pnca_complex.pdb"
|
|
"L35R","L4","PZA","L","L35",35,"R",NA,"Sensitive","OM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",17.42,-0.653,-1.493,-2.11958,-2.016,-0.88,64,80,0.183,4,4,35,0.174129353233831,"loop",1.43333333333333,4.69,0.0025873221216041,0.284614813531639,0.28461481380629,0.284630509244736,2.62510215004498,-30,-32,0,-2,-30,0,0,0,0,-2,0,-2,0,0,0,0,0,-6,0,-6,-2,-2,0,-8,-2,-0.165400202634245,-0.38578811369509,-0.40751749596247,-0.343734015345269,-0.230366492146597,0.673684210526316,0.0586538461538462,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","147/150","G:A:S:M:T:Q:V:L:I",-1.25661854335884,0.0842996990557667,0.727940577686249,-1.72626527752167,0.0461651045270816,0.934717733973448,-0.545742499657136,0.0746087863378038,1.1272100246275,0.033101827382896,1.11162498496942,0.105185735611338,"lineage4","other_mutations_pyrazinamide","ARG",0,"ERR1023451","ERR1023451","lineage4.9","","","pnca_p.leu35arg","A","T","LEU","LA35","pnca_complex.pdb"
|
|
"L35R","L4","PZA","L","L35",35,"R",0,"Sensitive","OM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",17.42,-0.653,-1.493,-2.11958,-2.016,-0.88,64,80,0.183,4,4,35,0.174129353233831,"loop",1.43333333333333,4.69,0.0025873221216041,0.284614813531639,0.28461481380629,0.284630509244736,2.62510215004498,-30,-32,0,-2,-30,0,0,0,0,-2,0,-2,0,0,0,0,0,-6,0,-6,-2,-2,0,-8,-2,-0.165400202634245,-0.38578811369509,-0.40751749596247,-0.343734015345269,-0.230366492146597,0.673684210526316,0.0586538461538462,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","147/150","G:A:S:M:T:Q:V:L:I",-1.25661854335884,0.0842996990557667,0.727940577686249,-1.72626527752167,0.0461651045270816,0.934717733973448,-0.545742499657136,0.0746087863378038,1.1272100246275,0.033101827382896,1.11162498496942,0.105185735611338,"lineage4","other_mutations_pyrazinamide","ARG",0,"ERR037468","ERR037468","lineage4.9","mw","Malawi","pnca_p.leu35arg","A","T","LEU","LA35","pnca_complex.pdb"
|
|
"L35R","L4","PZA","L","L35",35,"R",NA,"Sensitive","OM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",17.42,-0.653,-1.493,-2.11958,-2.016,-0.88,64,80,0.183,4,4,35,0.174129353233831,"loop",1.43333333333333,4.69,0.0025873221216041,0.284614813531639,0.28461481380629,0.284630509244736,2.62510215004498,-30,-32,0,-2,-30,0,0,0,0,-2,0,-2,0,0,0,0,0,-6,0,-6,-2,-2,0,-8,-2,-0.165400202634245,-0.38578811369509,-0.40751749596247,-0.343734015345269,-0.230366492146597,0.673684210526316,0.0586538461538462,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","147/150","G:A:S:M:T:Q:V:L:I",-1.25661854335884,0.0842996990557667,0.727940577686249,-1.72626527752167,0.0461651045270816,0.934717733973448,-0.545742499657136,0.0746087863378038,1.1272100246275,0.033101827382896,1.11162498496942,0.105185735611338,"lineage4","other_mutations_pyrazinamide","ARG",0,"ERR190380","ERR190380","lineage4.9","mw","Malawi","pnca_p.leu35arg","A","T","LEU","LA35","pnca_complex.pdb"
|
|
"L35R","L4","PZA","L","L35",35,"R",NA,"Sensitive","OM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",17.42,-0.653,-1.493,-2.11958,-2.016,-0.88,64,80,0.183,4,4,35,0.174129353233831,"loop",1.43333333333333,4.69,0.0025873221216041,0.284614813531639,0.28461481380629,0.284630509244736,2.62510215004498,-30,-32,0,-2,-30,0,0,0,0,-2,0,-2,0,0,0,0,0,-6,0,-6,-2,-2,0,-8,-2,-0.165400202634245,-0.38578811369509,-0.40751749596247,-0.343734015345269,-0.230366492146597,0.673684210526316,0.0586538461538462,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","147/150","G:A:S:M:T:Q:V:L:I",-1.25661854335884,0.0842996990557667,0.727940577686249,-1.72626527752167,0.0461651045270816,0.934717733973448,-0.545742499657136,0.0746087863378038,1.1272100246275,0.033101827382896,1.11162498496942,0.105185735611338,"lineage4","other_mutations_pyrazinamide","ARG",0,"ERR126610","ERR126610","lineage4.9","mw","Malawi","pnca_p.leu35arg","A","T","LEU","LA35","pnca_complex.pdb"
|
|
"L35R","L4","PZA","L","L35",35,"R",NA,"Sensitive","OM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",17.42,-0.653,-1.493,-2.11958,-2.016,-0.88,64,80,0.183,4,4,35,0.174129353233831,"loop",1.43333333333333,4.69,0.0025873221216041,0.284614813531639,0.28461481380629,0.284630509244736,2.62510215004498,-30,-32,0,-2,-30,0,0,0,0,-2,0,-2,0,0,0,0,0,-6,0,-6,-2,-2,0,-8,-2,-0.165400202634245,-0.38578811369509,-0.40751749596247,-0.343734015345269,-0.230366492146597,0.673684210526316,0.0586538461538462,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","147/150","G:A:S:M:T:Q:V:L:I",-1.25661854335884,0.0842996990557667,0.727940577686249,-1.72626527752167,0.0461651045270816,0.934717733973448,-0.545742499657136,0.0746087863378038,1.1272100246275,0.033101827382896,1.11162498496942,0.105185735611338,"lineage4","other_mutations_pyrazinamide","ARG",0,"ERR216928","ERR216928","lineage4.9","mw","Malawi","pnca_p.leu35arg","A","T","LEU","LA35","pnca_complex.pdb"
|
|
"L35R","L4","PZA","L","L35",35,"R",NA,"Sensitive","OM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",17.42,-0.653,-1.493,-2.11958,-2.016,-0.88,64,80,0.183,4,4,35,0.174129353233831,"loop",1.43333333333333,4.69,0.0025873221216041,0.284614813531639,0.28461481380629,0.284630509244736,2.62510215004498,-30,-32,0,-2,-30,0,0,0,0,-2,0,-2,0,0,0,0,0,-6,0,-6,-2,-2,0,-8,-2,-0.165400202634245,-0.38578811369509,-0.40751749596247,-0.343734015345269,-0.230366492146597,0.673684210526316,0.0586538461538462,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","147/150","G:A:S:M:T:Q:V:L:I",-1.25661854335884,0.0842996990557667,0.727940577686249,-1.72626527752167,0.0461651045270816,0.934717733973448,-0.545742499657136,0.0746087863378038,1.1272100246275,0.033101827382896,1.11162498496942,0.105185735611338,"lineage4","other_mutations_pyrazinamide","ARG",0,"011-1","ERR1750893","lineage4.9","zw","","pnca_p.leu35arg","A","T","LEU","LA35","pnca_complex.pdb"
|
|
"L35R","L4","PZA","L","L35",35,"R",NA,"Sensitive","OM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",17.42,-0.653,-1.493,-2.11958,-2.016,-0.88,64,80,0.183,4,4,35,0.174129353233831,"loop",1.43333333333333,4.69,0.0025873221216041,0.284614813531639,0.28461481380629,0.284630509244736,2.62510215004498,-30,-32,0,-2,-30,0,0,0,0,-2,0,-2,0,0,0,0,0,-6,0,-6,-2,-2,0,-8,-2,-0.165400202634245,-0.38578811369509,-0.40751749596247,-0.343734015345269,-0.230366492146597,0.673684210526316,0.0586538461538462,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","147/150","G:A:S:M:T:Q:V:L:I",-1.25661854335884,0.0842996990557667,0.727940577686249,-1.72626527752167,0.0461651045270816,0.934717733973448,-0.545742499657136,0.0746087863378038,1.1272100246275,0.033101827382896,1.11162498496942,0.105185735611338,"lineage4","other_mutations_pyrazinamide","ARG",0,"ERR1023437","ERR1023437","lineage4.9","","","pnca_p.leu35arg","A","T","LEU","LA35","pnca_complex.pdb"
|
|
"L35R","L4","PZA","L","L35",35,"R",NA,"Sensitive","OM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",17.42,-0.653,-1.493,-2.11958,-2.016,-0.88,64,80,0.183,4,4,35,0.174129353233831,"loop",1.43333333333333,4.69,0.0025873221216041,0.284614813531639,0.28461481380629,0.284630509244736,2.62510215004498,-30,-32,0,-2,-30,0,0,0,0,-2,0,-2,0,0,0,0,0,-6,0,-6,-2,-2,0,-8,-2,-0.165400202634245,-0.38578811369509,-0.40751749596247,-0.343734015345269,-0.230366492146597,0.673684210526316,0.0586538461538462,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","147/150","G:A:S:M:T:Q:V:L:I",-1.25661854335884,0.0842996990557667,0.727940577686249,-1.72626527752167,0.0461651045270816,0.934717733973448,-0.545742499657136,0.0746087863378038,1.1272100246275,0.033101827382896,1.11162498496942,0.105185735611338,"lineage4","other_mutations_pyrazinamide","ARG",0,"ERR161052","ERR161052","lineage4.9","mw","Malawi","pnca_p.leu35arg","A","T","LEU","LA35","pnca_complex.pdb"
|
|
"L35R","L4","PZA","L","L35",35,"R",0,"Sensitive","OM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",17.42,-0.653,-1.493,-2.11958,-2.016,-0.88,64,80,0.183,4,4,35,0.174129353233831,"loop",1.43333333333333,4.69,0.0025873221216041,0.284614813531639,0.28461481380629,0.284630509244736,2.62510215004498,-30,-32,0,-2,-30,0,0,0,0,-2,0,-2,0,0,0,0,0,-6,0,-6,-2,-2,0,-8,-2,-0.165400202634245,-0.38578811369509,-0.40751749596247,-0.343734015345269,-0.230366492146597,0.673684210526316,0.0586538461538462,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","147/150","G:A:S:M:T:Q:V:L:I",-1.25661854335884,0.0842996990557667,0.727940577686249,-1.72626527752167,0.0461651045270816,0.934717733973448,-0.545742499657136,0.0746087863378038,1.1272100246275,0.033101827382896,1.11162498496942,0.105185735611338,"lineage4","other_mutations_pyrazinamide","ARG",0,"ERR2513363","ERR2513363","lineage4.9","gb","UK","pnca_p.leu35arg","A","T","LEU","LA35","pnca_complex.pdb"
|
|
"L35R","L4","PZA","L","L35",35,"R",NA,"Sensitive","OM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",17.42,-0.653,-1.493,-2.11958,-2.016,-0.88,64,80,0.183,4,4,35,0.174129353233831,"loop",1.43333333333333,4.69,0.0025873221216041,0.284614813531639,0.28461481380629,0.284630509244736,2.62510215004498,-30,-32,0,-2,-30,0,0,0,0,-2,0,-2,0,0,0,0,0,-6,0,-6,-2,-2,0,-8,-2,-0.165400202634245,-0.38578811369509,-0.40751749596247,-0.343734015345269,-0.230366492146597,0.673684210526316,0.0586538461538462,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","147/150","G:A:S:M:T:Q:V:L:I",-1.25661854335884,0.0842996990557667,0.727940577686249,-1.72626527752167,0.0461651045270816,0.934717733973448,-0.545742499657136,0.0746087863378038,1.1272100246275,0.033101827382896,1.11162498496942,0.105185735611338,"lineage4","other_mutations_pyrazinamide","ARG",0,"ERR036191","ERR036191","lineage4.9","mw","Malawi","pnca_p.leu35arg","A","T","LEU","LA35","pnca_complex.pdb"
|
|
"L35R","L4","PZA","L","L35",35,"R",0,"Sensitive","OM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",17.42,-0.653,-1.493,-2.11958,-2.016,-0.88,64,80,0.183,4,4,35,0.174129353233831,"loop",1.43333333333333,4.69,0.0025873221216041,0.284614813531639,0.28461481380629,0.284630509244736,2.62510215004498,-30,-32,0,-2,-30,0,0,0,0,-2,0,-2,0,0,0,0,0,-6,0,-6,-2,-2,0,-8,-2,-0.165400202634245,-0.38578811369509,-0.40751749596247,-0.343734015345269,-0.230366492146597,0.673684210526316,0.0586538461538462,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","147/150","G:A:S:M:T:Q:V:L:I",-1.25661854335884,0.0842996990557667,0.727940577686249,-1.72626527752167,0.0461651045270816,0.934717733973448,-0.545742499657136,0.0746087863378038,1.1272100246275,0.033101827382896,1.11162498496942,0.105185735611338,"lineage4","other_mutations_pyrazinamide","ARG",0,"ERR176824","ERR176824","lineage4.9","mw","Malawi","pnca_p.leu35arg","A","T","LEU","LA35","pnca_complex.pdb"
|
|
"L35R","L4","PZA","L","L35",35,"R",0,"MDR","OM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",17.42,-0.653,-1.493,-2.11958,-2.016,-0.88,64,80,0.183,4,4,35,0.174129353233831,"loop",1.43333333333333,4.69,0.0025873221216041,0.284614813531639,0.28461481380629,0.284630509244736,2.62510215004498,-30,-32,0,-2,-30,0,0,0,0,-2,0,-2,0,0,0,0,0,-6,0,-6,-2,-2,0,-8,-2,-0.165400202634245,-0.38578811369509,-0.40751749596247,-0.343734015345269,-0.230366492146597,0.673684210526316,0.0586538461538462,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","147/150","G:A:S:M:T:Q:V:L:I",-1.25661854335884,0.0842996990557667,0.727940577686249,-1.72626527752167,0.0461651045270816,0.934717733973448,-0.545742499657136,0.0746087863378038,1.1272100246275,0.033101827382896,1.11162498496942,0.105185735611338,"lineage4","other_mutations_pyrazinamide","ARG",0,"ERR2515166","ERR2515166","lineage4.9","za","South Africa","pnca_p.leu35arg","A","T","LEU","LA35","pnca_complex.pdb"
|
|
"L35R","L4","PZA","L","L35",35,"R",NA,"Sensitive","OM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",17.42,-0.653,-1.493,-2.11958,-2.016,-0.88,64,80,0.183,4,4,35,0.174129353233831,"loop",1.43333333333333,4.69,0.0025873221216041,0.284614813531639,0.28461481380629,0.284630509244736,2.62510215004498,-30,-32,0,-2,-30,0,0,0,0,-2,0,-2,0,0,0,0,0,-6,0,-6,-2,-2,0,-8,-2,-0.165400202634245,-0.38578811369509,-0.40751749596247,-0.343734015345269,-0.230366492146597,0.673684210526316,0.0586538461538462,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","147/150","G:A:S:M:T:Q:V:L:I",-1.25661854335884,0.0842996990557667,0.727940577686249,-1.72626527752167,0.0461651045270816,0.934717733973448,-0.545742499657136,0.0746087863378038,1.1272100246275,0.033101827382896,1.11162498496942,0.105185735611338,"lineage4","other_mutations_pyrazinamide","ARG",0,"ERR245758","ERR245758","lineage4.9","mw","Malawi","pnca_p.leu35arg","A","T","LEU","LA35","pnca_complex.pdb"
|
|
"L35R","L4","PZA","L","L35",35,"R",NA,"Sensitive","OM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",17.42,-0.653,-1.493,-2.11958,-2.016,-0.88,64,80,0.183,4,4,35,0.174129353233831,"loop",1.43333333333333,4.69,0.0025873221216041,0.284614813531639,0.28461481380629,0.284630509244736,2.62510215004498,-30,-32,0,-2,-30,0,0,0,0,-2,0,-2,0,0,0,0,0,-6,0,-6,-2,-2,0,-8,-2,-0.165400202634245,-0.38578811369509,-0.40751749596247,-0.343734015345269,-0.230366492146597,0.673684210526316,0.0586538461538462,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","147/150","G:A:S:M:T:Q:V:L:I",-1.25661854335884,0.0842996990557667,0.727940577686249,-1.72626527752167,0.0461651045270816,0.934717733973448,-0.545742499657136,0.0746087863378038,1.1272100246275,0.033101827382896,1.11162498496942,0.105185735611338,"lineage4","other_mutations_pyrazinamide","ARG",0,"ERR176585","ERR176585","lineage4.9","mw","Malawi","pnca_p.leu35arg","A","T","LEU","LA35","pnca_complex.pdb"
|
|
"L35R","L4","PZA","L","L35",35,"R",0,"Pre-MDR","OM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",17.42,-0.653,-1.493,-2.11958,-2.016,-0.88,64,80,0.183,4,4,35,0.174129353233831,"loop",1.43333333333333,4.69,0.0025873221216041,0.284614813531639,0.28461481380629,0.284630509244736,2.62510215004498,-30,-32,0,-2,-30,0,0,0,0,-2,0,-2,0,0,0,0,0,-6,0,-6,-2,-2,0,-8,-2,-0.165400202634245,-0.38578811369509,-0.40751749596247,-0.343734015345269,-0.230366492146597,0.673684210526316,0.0586538461538462,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","147/150","G:A:S:M:T:Q:V:L:I",-1.25661854335884,0.0842996990557667,0.727940577686249,-1.72626527752167,0.0461651045270816,0.934717733973448,-0.545742499657136,0.0746087863378038,1.1272100246275,0.033101827382896,1.11162498496942,0.105185735611338,"lineage4","other_mutations_pyrazinamide","ARG",0,"ERR2515329","ERR2515329","lineage4.9","za","South Africa","pnca_p.leu35arg","A","T","LEU","LA35","pnca_complex.pdb"
|
|
"L35R","L4","PZA","L","L35",35,"R",0,"MDR","OM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",17.42,-0.653,-1.493,-2.11958,-2.016,-0.88,64,80,0.183,4,4,35,0.174129353233831,"loop",1.43333333333333,4.69,0.0025873221216041,0.284614813531639,0.28461481380629,0.284630509244736,2.62510215004498,-30,-32,0,-2,-30,0,0,0,0,-2,0,-2,0,0,0,0,0,-6,0,-6,-2,-2,0,-8,-2,-0.165400202634245,-0.38578811369509,-0.40751749596247,-0.343734015345269,-0.230366492146597,0.673684210526316,0.0586538461538462,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","147/150","G:A:S:M:T:Q:V:L:I",-1.25661854335884,0.0842996990557667,0.727940577686249,-1.72626527752167,0.0461651045270816,0.934717733973448,-0.545742499657136,0.0746087863378038,1.1272100246275,0.033101827382896,1.11162498496942,0.105185735611338,"lineage4","other_mutations_pyrazinamide","ARG",0,"SRR2101505,SAMN03648752","SRR2101505","lineage4.9","","","pnca_p.leu35arg","A","T","LEU","LA35","pnca_complex.pdb"
|
|
"L35R","L4","PZA","L","L35",35,"R",NA,"Sensitive","OM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",17.42,-0.653,-1.493,-2.11958,-2.016,-0.88,64,80,0.183,4,4,35,0.174129353233831,"loop",1.43333333333333,4.69,0.0025873221216041,0.284614813531639,0.28461481380629,0.284630509244736,2.62510215004498,-30,-32,0,-2,-30,0,0,0,0,-2,0,-2,0,0,0,0,0,-6,0,-6,-2,-2,0,-8,-2,-0.165400202634245,-0.38578811369509,-0.40751749596247,-0.343734015345269,-0.230366492146597,0.673684210526316,0.0586538461538462,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","147/150","G:A:S:M:T:Q:V:L:I",-1.25661854335884,0.0842996990557667,0.727940577686249,-1.72626527752167,0.0461651045270816,0.934717733973448,-0.545742499657136,0.0746087863378038,1.1272100246275,0.033101827382896,1.11162498496942,0.105185735611338,"lineage4","other_mutations_pyrazinamide","ARG",0,"ERR212076","ERR212076","lineage4.9","mw","Malawi","pnca_p.leu35arg","A","T","LEU","LA35","pnca_complex.pdb"
|
|
"L35R","L4","PZA","L","L35",35,"R",NA,"Sensitive","OM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",17.42,-0.653,-1.493,-2.11958,-2.016,-0.88,64,80,0.183,4,4,35,0.174129353233831,"loop",1.43333333333333,4.69,0.0025873221216041,0.284614813531639,0.28461481380629,0.284630509244736,2.62510215004498,-30,-32,0,-2,-30,0,0,0,0,-2,0,-2,0,0,0,0,0,-6,0,-6,-2,-2,0,-8,-2,-0.165400202634245,-0.38578811369509,-0.40751749596247,-0.343734015345269,-0.230366492146597,0.673684210526316,0.0586538461538462,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","147/150","G:A:S:M:T:Q:V:L:I",-1.25661854335884,0.0842996990557667,0.727940577686249,-1.72626527752167,0.0461651045270816,0.934717733973448,-0.545742499657136,0.0746087863378038,1.1272100246275,0.033101827382896,1.11162498496942,0.105185735611338,"lineage4","other_mutations_pyrazinamide","ARG",0,"ERR176636","ERR176636","lineage4.9","mw","Malawi","pnca_p.leu35arg","A","T","LEU","LA35","pnca_complex.pdb"
|
|
"L35R","L4","PZA","L","L35",35,"R",NA,"Pre-MDR","OM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",17.42,-0.653,-1.493,-2.11958,-2.016,-0.88,64,80,0.183,4,4,35,0.174129353233831,"loop",1.43333333333333,4.69,0.0025873221216041,0.284614813531639,0.28461481380629,0.284630509244736,2.62510215004498,-30,-32,0,-2,-30,0,0,0,0,-2,0,-2,0,0,0,0,0,-6,0,-6,-2,-2,0,-8,-2,-0.165400202634245,-0.38578811369509,-0.40751749596247,-0.343734015345269,-0.230366492146597,0.673684210526316,0.0586538461538462,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","147/150","G:A:S:M:T:Q:V:L:I",-1.25661854335884,0.0842996990557667,0.727940577686249,-1.72626527752167,0.0461651045270816,0.934717733973448,-0.545742499657136,0.0746087863378038,1.1272100246275,0.033101827382896,1.11162498496942,0.105185735611338,"lineage4","other_mutations_pyrazinamide","ARG",0,"ERR212158","ERR212158","lineage4.9","mw","Malawi","pnca_p.leu35arg","A","T","LEU","LA35","pnca_complex.pdb"
|
|
"L35R","L4","PZA","L","L35",35,"R",NA,"Sensitive","OM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",17.42,-0.653,-1.493,-2.11958,-2.016,-0.88,64,80,0.183,4,4,35,0.174129353233831,"loop",1.43333333333333,4.69,0.0025873221216041,0.284614813531639,0.28461481380629,0.284630509244736,2.62510215004498,-30,-32,0,-2,-30,0,0,0,0,-2,0,-2,0,0,0,0,0,-6,0,-6,-2,-2,0,-8,-2,-0.165400202634245,-0.38578811369509,-0.40751749596247,-0.343734015345269,-0.230366492146597,0.673684210526316,0.0586538461538462,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","147/150","G:A:S:M:T:Q:V:L:I",-1.25661854335884,0.0842996990557667,0.727940577686249,-1.72626527752167,0.0461651045270816,0.934717733973448,-0.545742499657136,0.0746087863378038,1.1272100246275,0.033101827382896,1.11162498496942,0.105185735611338,"lineage4","other_mutations_pyrazinamide","ARG",0,"ERR176808","ERR176808","lineage4.9","mw","Malawi","pnca_p.leu35arg","A","T","LEU","LA35","pnca_complex.pdb"
|
|
"L35R","L4","PZA","L","L35",35,"R",0,"Sensitive","OM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",17.42,-0.653,-1.493,-2.11958,-2.016,-0.88,64,80,0.183,4,4,35,0.174129353233831,"loop",1.43333333333333,4.69,0.0025873221216041,0.284614813531639,0.28461481380629,0.284630509244736,2.62510215004498,-30,-32,0,-2,-30,0,0,0,0,-2,0,-2,0,0,0,0,0,-6,0,-6,-2,-2,0,-8,-2,-0.165400202634245,-0.38578811369509,-0.40751749596247,-0.343734015345269,-0.230366492146597,0.673684210526316,0.0586538461538462,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","147/150","G:A:S:M:T:Q:V:L:I",-1.25661854335884,0.0842996990557667,0.727940577686249,-1.72626527752167,0.0461651045270816,0.934717733973448,-0.545742499657136,0.0746087863378038,1.1272100246275,0.033101827382896,1.11162498496942,0.105185735611338,"lineage4","other_mutations_pyrazinamide","ARG",0,"ERR176761","ERR176761","lineage4.9","mw","Malawi","pnca_p.leu35arg","A","T","LEU","LA35","pnca_complex.pdb"
|
|
"L35R","L4","PZA","L","L35",35,"R",NA,"Sensitive","OM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",17.42,-0.653,-1.493,-2.11958,-2.016,-0.88,64,80,0.183,4,4,35,0.174129353233831,"loop",1.43333333333333,4.69,0.0025873221216041,0.284614813531639,0.28461481380629,0.284630509244736,2.62510215004498,-30,-32,0,-2,-30,0,0,0,0,-2,0,-2,0,0,0,0,0,-6,0,-6,-2,-2,0,-8,-2,-0.165400202634245,-0.38578811369509,-0.40751749596247,-0.343734015345269,-0.230366492146597,0.673684210526316,0.0586538461538462,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","147/150","G:A:S:M:T:Q:V:L:I",-1.25661854335884,0.0842996990557667,0.727940577686249,-1.72626527752167,0.0461651045270816,0.934717733973448,-0.545742499657136,0.0746087863378038,1.1272100246275,0.033101827382896,1.11162498496942,0.105185735611338,"lineage4","other_mutations_pyrazinamide","ARG",0,"011-2","ERR1750894","lineage4.9","zw","","pnca_p.leu35arg","A","T","LEU","LA35","pnca_complex.pdb"
|
|
"L35R","L4","PZA","L","L35",35,"R",NA,"Pre-XDR","OM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",17.42,-0.653,-1.493,-2.11958,-2.016,-0.88,64,80,0.183,4,4,35,0.174129353233831,"loop",1.43333333333333,4.69,0.0025873221216041,0.284614813531639,0.28461481380629,0.284630509244736,2.62510215004498,-30,-32,0,-2,-30,0,0,0,0,-2,0,-2,0,0,0,0,0,-6,0,-6,-2,-2,0,-8,-2,-0.165400202634245,-0.38578811369509,-0.40751749596247,-0.343734015345269,-0.230366492146597,0.673684210526316,0.0586538461538462,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","147/150","G:A:S:M:T:Q:V:L:I",-1.25661854335884,0.0842996990557667,0.727940577686249,-1.72626527752167,0.0461651045270816,0.934717733973448,-0.545742499657136,0.0746087863378038,1.1272100246275,0.033101827382896,1.11162498496942,0.105185735611338,"lineage4","other_mutations_pyrazinamide","ARG",0,"ERR2515528","ERR2515528","lineage4.9","za","South Africa","pnca_p.leu35arg","A","T","LEU","LA35","pnca_complex.pdb"
|
|
"E37V","L4","PZA","E","E37",37,"V",0,"Sensitive","OM","hydrophilic","hydrophobic","acidic","non-polar","neg","non-polar",24.08,-0.519,-0.033,0.085964,-0.065,-0.26,-32,66,2.736,1,1,138,0.618834080717489,"loop",0.0333333333333333,3.58,7.18700589334483e-05,2.42412778478352,0.0001249735077034,0,1.03410070803344e-29,12,18,0,2,16,0,0,0,0,2,0,2,0,0,0,0,0,-1,0,-2,1,2,0,2,-2,-0.131458966565349,-0.0085271317829457,0.00313099600084499,-0.0110826939471441,-0.0680628272251308,-0.344086021505376,0.876923076923077,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","neutral",1.183,3.125,"1:1","95/150","F:E:Q:V:N:L:I:R:T:W:H:Y:M:G:A:S:P:D",-8.9874087814964,0.940032862253632,119.468044435489,-0.0752285585987761,NA,4692673.51081157,0.384555509373631,1,0,0,188.544222231268,0.999999999999997,"lineage4","other_mutations_pyrazinamide","VAL",0,"SAMN03647581,SRR2100408","SRR2100408","lineage4.1.1.1","","","pnca_p.glu37val","A","S","GLU","EA37","pnca_complex.pdb"
|
|
"Y41C","L4","PZA","Y","Y41",41,"C",0,"MDR","OM","hydrophobic","hydrophobic","neutral","neutral","polar","non-polar",19.063,-1.07,-1.057,4.03027,-1.836,0.19,37,66,-0.477,7,7,35,0.133079847908745,"loop",-2.66666666666667,4.97,7.18700589334483e-05,2.42412778478352,0.0001249735077034,0,1.03410070803344e-29,46,8,0,0,8,0,0,0,0,2,0,-2,4,0,0,0,0,2,0,-2,4,10,0,2,10,-0.271023302938197,-0.27312661498708,0.146791206229649,-0.31304347826087,0.106741573033708,0.389473684210526,-0.392915980230643,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.674,-0.411,"7:7","147/150","L:N:R:F:H:Y:W:A:G",-8.98740878149643,0.940032862253634,119.468044435493,-0.0752285585987739,NA,4692673.51081287,0.384555509373631,1,0,0,188.544222231268,0.999999999999997,"lineage4","other_mutations_pyrazinamide","CYS",0,"ERR2510731","ERR2510731","lineage4.1.2.1","it","Italy","pnca_p.tyr41cys","A","-","TYR","YA41","pnca_complex.pdb"
|
|
"Y41D","L4","PZA","Y","Y41",41,"D",1,"Pre-MDR","OM","hydrophobic","hydrophilic","neutral","acidic","polar","neg",19.063,-0.298,-2.11,5.35024,-3.198,-1.85,70,85,-0.477,7,7,35,0.133079847908745,"loop",-2.66666666666667,4.97,7.18700589334483e-05,9.70142977291842,188179.926264407,Inf,0.763784339928386,36,-28,0,-4,-24,0,0,0,0,0,0,-2,2,0,0,0,0,2,0,-2,4,4,0,0,4,-0.0754812563323201,-0.545219638242894,0.194867386854508,-0.545268542199489,-0.484293193717278,0.736842105263158,-0.392915980230643,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.674,-0.411,"7:7","147/150","L:N:R:F:H:Y:W:A:G",12.1451538387252,0.919026337424193,119.468044436159,0.101660271548308,5.01153666069528e-06,NA,0.986835744238421,0.170978870202674,0.767057556984365,0.124324963210678,Inf,0.382146811758261,"lineage4","other_mutations_pyrazinamide","ASP",0,"SRR2469373,SAMN04099730","SRR2469373","lineage4.1.1.3","","","pnca_p.tyr41asp","A","-","TYR","YA41","pnca_complex.pdb"
|
|
"H43D","L3","PZA","H","H43",43,"D",0,"Pre-XDR","OM","hydrophobic","hydrophilic","basic","acidic","pos","neg",19.543,-0.912,-1.596,3.54222,-0.971,-1.78,27,63,1.071,1,1,40,0.178571428571428,"strand",-0.733333333333333,4.75,7.18700589334483e-05,2.42412778478352,0.0001249735077034,0,1.03410070803344e-29,6,-24,0,-2,-22,0,0,0,0,0,0,2,0,0,0,0,0,-2,0,-2,-6,0,0,0,0,-0.231003039513678,-0.412403100775194,0.129015362874147,-0.165558397271952,-0.465968586387435,0.284210526315789,0.343269230769231,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.59,1.183,"3:1","147/150","Y:F:H:Q:L:N:V:R:I:C:A:M:T:P:D",-8.98740878149641,0.940032862253634,119.468044435492,-0.0752285585987746,NA,4692673.51081392,0.384555509373631,1,0,0,188.544222231268,0.999999999999997,"lineage3","other_mutations_pyrazinamide","ASP",0,"ERR2510343","ERR2510343","lineage3","pk","Pakistan","pnca_p.his43asp","A","E","HIS","HA43","pnca_complex.pdb"
|
|
"H43P","L4","PZA","H","H43",43,"P",NA,"MDR","DM","hydrophobic","hydrophilic","basic","non-polar","pos","non-polar",19.543,-1.878,-0.892,2.10447,-1.154,0.4,30,66,1.071,1,1,40,0.178571428571428,"strand",-0.733333333333333,4.75,NA,NA,NA,NA,NA,18,0,0,0,0,0,0,0,0,2,0,0,2,0,0,0,0,-4,2,-3,-4,4,0,4,-4,-0.475683890577508,-0.230490956072351,0.0766493782734431,-0.196760443307758,0.224719101123595,0.315789473684211,0.343269230769231,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",0.59,1.183,"3:1","147/150","Y:F:H:Q:L:N:V:R:I:C:A:M:T:P:D",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage4","dr_mutations_pyrazinamide","PRO",0,"SAMN02414879","SRR1162792_SRR1166871_SRR1144753_SRR1146380","lineage4.6.1.2","se","Sweden","pnca_p.his43pro","A","E","HIS","HA43","pnca_complex.pdb"
|
|
"H43P","L4","PZA","H","H43",43,"P",NA,"MDR","DM","hydrophobic","hydrophilic","basic","non-polar","pos","non-polar",19.543,-1.878,-0.892,2.10447,-1.154,0.4,30,66,1.071,1,1,40,0.178571428571428,"strand",-0.733333333333333,4.75,NA,NA,NA,NA,NA,18,0,0,0,0,0,0,0,0,2,0,0,2,0,0,0,0,-4,2,-3,-4,4,0,4,-4,-0.475683890577508,-0.230490956072351,0.0766493782734431,-0.196760443307758,0.224719101123595,0.315789473684211,0.343269230769231,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",0.59,1.183,"3:1","147/150","Y:F:H:Q:L:N:V:R:I:C:A:M:T:P:D",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage4","dr_mutations_pyrazinamide","PRO",0,"SAMN02586099","SRR1184334_SRR1172783_SRR1196493_SRR1175048","lineage4.3.4.2","za","South Africa","pnca_p.his43pro","A","E","HIS","HA43","pnca_complex.pdb"
|
|
"H43Y","L1","PZA","H","H43",43,"Y",NA,"Sensitive","OM","hydrophobic","hydrophobic","basic","neutral","pos","polar",19.543,-1.341,0.984,-0.653353,-0.455,1.37,-33,66,1.071,1,1,40,0.178571428571428,"strand",-0.733333333333333,4.75,NA,NA,NA,NA,NA,-22,-6,0,-2,-4,0,0,0,0,0,0,-2,2,0,0,0,0,-1,0,-2,0,4,0,-2,2,-0.339665653495441,0.836734693877551,-0.125615819426286,-0.0775788576300085,0.769662921348315,-0.354838709677419,0.343269230769231,"Destabilising","Stabilising","Stabilising","Destabilising","Stabilising","neutral",0.59,1.183,"3:1","147/150","Y:F:H:Q:L:N:V:R:I:C:A:M:T:P:D",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage1","other_mutations_pyrazinamide","TYR",0,"ERR3276024","ERR3276024","lineage1.2.1","nl","Netherlands","pnca_p.his43tyr","A","E","HIS","HA43","pnca_complex.pdb"
|
|
"H43Y","L4","PZA","H","H43",43,"Y",NA,"Sensitive","OM","hydrophobic","hydrophobic","basic","neutral","pos","polar",19.543,-1.341,0.984,-0.653353,-0.455,1.37,-33,66,1.071,1,1,40,0.178571428571428,"strand",-0.733333333333333,4.75,NA,NA,NA,NA,NA,-22,-6,0,-2,-4,0,0,0,0,0,0,-2,2,0,0,0,0,-1,0,-2,0,4,0,-2,2,-0.339665653495441,0.836734693877551,-0.125615819426286,-0.0775788576300085,0.769662921348315,-0.354838709677419,0.343269230769231,"Destabilising","Stabilising","Stabilising","Destabilising","Stabilising","neutral",0.59,1.183,"3:1","147/150","Y:F:H:Q:L:N:V:R:I:C:A:M:T:P:D",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage4","other_mutations_pyrazinamide","TYR",0,"ERR025458","ERR025458","lineage4.3.2","nl","Netherlands","pnca_p.his43tyr","A","E","HIS","HA43","pnca_complex.pdb"
|
|
"H43Y","L4","PZA","H","H43",43,"Y",NA,"Sensitive","OM","hydrophobic","hydrophobic","basic","neutral","pos","polar",19.543,-1.341,0.984,-0.653353,-0.455,1.37,-33,66,1.071,1,1,40,0.178571428571428,"strand",-0.733333333333333,4.75,NA,NA,NA,NA,NA,-22,-6,0,-2,-4,0,0,0,0,0,0,-2,2,0,0,0,0,-1,0,-2,0,4,0,-2,2,-0.339665653495441,0.836734693877551,-0.125615819426286,-0.0775788576300085,0.769662921348315,-0.354838709677419,0.343269230769231,"Destabilising","Stabilising","Stabilising","Destabilising","Stabilising","neutral",0.59,1.183,"3:1","147/150","Y:F:H:Q:L:N:V:R:I:C:A:M:T:P:D",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage4","other_mutations_pyrazinamide","TYR",0,"ERR025459","ERR025459","lineage4.3.2","nl","Netherlands","pnca_p.his43tyr","A","E","HIS","HA43","pnca_complex.pdb"
|
|
"H43Y","L4","PZA","H","H43",43,"Y",NA,"Sensitive","OM","hydrophobic","hydrophobic","basic","neutral","pos","polar",19.543,-1.341,0.984,-0.653353,-0.455,1.37,-33,66,1.071,1,1,40,0.178571428571428,"strand",-0.733333333333333,4.75,NA,NA,NA,NA,NA,-22,-6,0,-2,-4,0,0,0,0,0,0,-2,2,0,0,0,0,-1,0,-2,0,4,0,-2,2,-0.339665653495441,0.836734693877551,-0.125615819426286,-0.0775788576300085,0.769662921348315,-0.354838709677419,0.343269230769231,"Destabilising","Stabilising","Stabilising","Destabilising","Stabilising","neutral",0.59,1.183,"3:1","147/150","Y:F:H:Q:L:N:V:R:I:C:A:M:T:P:D",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage4","other_mutations_pyrazinamide","TYR",0,"ERR025460","ERR025460","lineage4.3.2","nl","Netherlands","pnca_p.his43tyr","A","E","HIS","HA43","pnca_complex.pdb"
|
|
"H43Y","L4","PZA","H","H43",43,"Y",NA,"Sensitive","OM","hydrophobic","hydrophobic","basic","neutral","pos","polar",19.543,-1.341,0.984,-0.653353,-0.455,1.37,-33,66,1.071,1,1,40,0.178571428571428,"strand",-0.733333333333333,4.75,NA,NA,NA,NA,NA,-22,-6,0,-2,-4,0,0,0,0,0,0,-2,2,0,0,0,0,-1,0,-2,0,4,0,-2,2,-0.339665653495441,0.836734693877551,-0.125615819426286,-0.0775788576300085,0.769662921348315,-0.354838709677419,0.343269230769231,"Destabilising","Stabilising","Stabilising","Destabilising","Stabilising","neutral",0.59,1.183,"3:1","147/150","Y:F:H:Q:L:N:V:R:I:C:A:M:T:P:D",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage4","other_mutations_pyrazinamide","TYR",0,"ERR025451","ERR025451","lineage4.3.2","nl","Netherlands","pnca_p.his43tyr","A","E","HIS","HA43","pnca_complex.pdb"
|
|
"H43Y","L1","PZA","H","H43",43,"Y",NA,"Sensitive","OM","hydrophobic","hydrophobic","basic","neutral","pos","polar",19.543,-1.341,0.984,-0.653353,-0.455,1.37,-33,66,1.071,1,1,40,0.178571428571428,"strand",-0.733333333333333,4.75,NA,NA,NA,NA,NA,-22,-6,0,-2,-4,0,0,0,0,0,0,-2,2,0,0,0,0,-1,0,-2,0,4,0,-2,2,-0.339665653495441,0.836734693877551,-0.125615819426286,-0.0775788576300085,0.769662921348315,-0.354838709677419,0.343269230769231,"Destabilising","Stabilising","Stabilising","Destabilising","Stabilising","neutral",0.59,1.183,"3:1","147/150","Y:F:H:Q:L:N:V:R:I:C:A:M:T:P:D",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage1","other_mutations_pyrazinamide","TYR",0,"SRR5818611","SRR5818611","lineage1.2.1","dj","Djibouti","pnca_p.his43tyr","A","E","HIS","HA43","pnca_complex.pdb"
|
|
"V44A","L4","PZA","V","V44",44,"A",NA,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",17.073,-1.246,-2.343,3.40395,-1.839,-2.01,57,75,-0.194,6,6,13,0.0747126436781609,"strand",1.73333333333333,5.57,7.18700589334483e-05,9.70142977291842,188179.926264644,Inf,0.763784339928386,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,2,1,-0.315602836879433,-0.605426356589147,0.123979268497002,-0.313554987212276,-0.526178010471204,0.6,-0.159802306425041,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.411,-0.038,"7:5","149/150","T:A:Q:C:R:I:L:V",12.1451538387265,0.919026337424235,119.468044436235,0.101660271548254,5.01153666062486e-06,NA,0.986835744238421,0.170978870202674,0.767057556984365,0.124324963210678,Inf,0.382146811758261,"lineage4","other_mutations_pyrazinamide","ALA",0,"ERR1035326","ERR1035326","lineage4.7","br","Brazil","pnca_p.val44ala","A","E","VAL","VA44","pnca_complex.pdb"
|
|
"V44A","L3","PZA","V","V44",44,"A",1,"MDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",17.073,-1.246,-2.343,3.40395,-1.839,-2.01,57,75,-0.194,6,6,13,0.0747126436781609,"strand",1.73333333333333,5.57,7.18700589334483e-05,9.70142977291842,188179.926264644,Inf,0.763784339928386,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,2,1,-0.315602836879433,-0.605426356589147,0.123979268497002,-0.313554987212276,-0.526178010471204,0.6,-0.159802306425041,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.411,-0.038,"7:5","149/150","T:A:Q:C:R:I:L:V",12.1451538387265,0.919026337424235,119.468044436235,0.101660271548254,5.01153666062486e-06,NA,0.986835744238421,0.170978870202674,0.767057556984365,0.124324963210678,Inf,0.382146811758261,"lineage3","other_mutations_pyrazinamide","ALA",0,"TB-12","ERR2851365","lineage3","lb","Lebanon","pnca_p.val44ala","A","E","VAL","VA44","pnca_complex.pdb"
|
|
"V44G","L2","PZA","V","V44",44,"G",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",17.073,-1.136,-2.975,5.19527,-3.88,-2.43,74,85,-0.194,6,6,13,0.0747126436781609,"strand",1.73333333333333,5.57,0.0005030904125341,12.1451137320977,12.1450773794064,12.1416664151504,11.0019205274607,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-2,0,-2,0,4,0,5,19,-0.28774062816616,-0.768733850129199,0.18922304212589,-0.6615515771526,-0.636125654450262,0.778947368421053,-0.159802306425041,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.411,-0.038,"7:5","149/150","T:A:Q:C:R:I:L:V",2.4969239337312,0.0028293218857323,0.83629495944555,2.98569769616526,2.61610833082893,84.8371270838078,1.08440158608155,0.0022516005975125,2.64750864476206,1.98635523014012,127.719946645636,0.0009101752788745,"lineage2","dr_mutations_pyrazinamide","GLY",0,"SAMN03653308,SRS935929","SRR2024890","lineage2.2.1.1","cn","China","pnca_p.val44gly","A","E","VAL","VA44","pnca_complex.pdb"
|
|
"V44G","L2","PZA","V","V44",44,"G",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",17.073,-1.136,-2.975,5.19527,-3.88,-2.43,74,85,-0.194,6,6,13,0.0747126436781609,"strand",1.73333333333333,5.57,0.0005030904125341,12.1451137320977,12.1450773794064,12.1416664151504,11.0019205274607,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-2,0,-2,0,4,0,5,19,-0.28774062816616,-0.768733850129199,0.18922304212589,-0.6615515771526,-0.636125654450262,0.778947368421053,-0.159802306425041,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.411,-0.038,"7:5","149/150","T:A:Q:C:R:I:L:V",2.4969239337312,0.0028293218857323,0.83629495944555,2.98569769616526,2.61610833082893,84.8371270838078,1.08440158608155,0.0022516005975125,2.64750864476206,1.98635523014012,127.719946645636,0.0009101752788745,"lineage2","dr_mutations_pyrazinamide","GLY",0,"SRS797178","SRR1723695_SRR1723696","lineage2.2.1.1","cn","China:Jiangxi","pnca_p.val44gly","A","E","VAL","VA44","pnca_complex.pdb"
|
|
"V44G","L2","PZA","V","V44",44,"G",1,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",17.073,-1.136,-2.975,5.19527,-3.88,-2.43,74,85,-0.194,6,6,13,0.0747126436781609,"strand",1.73333333333333,5.57,0.0005030904125341,12.1451137320977,12.1450773794064,12.1416664151504,11.0019205274607,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-2,0,-2,0,4,0,5,19,-0.28774062816616,-0.768733850129199,0.18922304212589,-0.6615515771526,-0.636125654450262,0.778947368421053,-0.159802306425041,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.411,-0.038,"7:5","149/150","T:A:Q:C:R:I:L:V",2.4969239337312,0.0028293218857323,0.83629495944555,2.98569769616526,2.61610833082893,84.8371270838078,1.08440158608155,0.0022516005975125,2.64750864476206,1.98635523014012,127.719946645636,0.0009101752788745,"lineage2","dr_mutations_pyrazinamide","GLY",0,"MDR_14314","SRR6824377","lineage2.2.1.1","cn","China: Guangfeng County, Shangrao City, Jiangxi Province","pnca_p.val44gly","A","E","VAL","VA44","pnca_complex.pdb"
|
|
"V44G","L2","PZA","V","V44",44,"G",1,"XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",17.073,-1.136,-2.975,5.19527,-3.88,-2.43,74,85,-0.194,6,6,13,0.0747126436781609,"strand",1.73333333333333,5.57,0.0005030904125341,12.1451137320977,12.1450773794064,12.1416664151504,11.0019205274607,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-2,0,-2,0,4,0,5,19,-0.28774062816616,-0.768733850129199,0.18922304212589,-0.6615515771526,-0.636125654450262,0.778947368421053,-0.159802306425041,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.411,-0.038,"7:5","149/150","T:A:Q:C:R:I:L:V",2.4969239337312,0.0028293218857323,0.83629495944555,2.98569769616526,2.61610833082893,84.8371270838078,1.08440158608155,0.0022516005975125,2.64750864476206,1.98635523014012,127.719946645636,0.0009101752788745,"lineage2","dr_mutations_pyrazinamide","GLY",0,"ERS1831678","ERR2041933","lineage2.2.1","","Germany_extendedCAO","pnca_p.val44gly","A","E","VAL","VA44","pnca_complex.pdb"
|
|
"V44G","L2","PZA","V","V44",44,"G",1,"XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",17.073,-1.136,-2.975,5.19527,-3.88,-2.43,74,85,-0.194,6,6,13,0.0747126436781609,"strand",1.73333333333333,5.57,0.0005030904125341,12.1451137320977,12.1450773794064,12.1416664151504,11.0019205274607,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-2,0,-2,0,4,0,5,19,-0.28774062816616,-0.768733850129199,0.18922304212589,-0.6615515771526,-0.636125654450262,0.778947368421053,-0.159802306425041,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.411,-0.038,"7:5","149/150","T:A:Q:C:R:I:L:V",2.4969239337312,0.0028293218857323,0.83629495944555,2.98569769616526,2.61610833082893,84.8371270838078,1.08440158608155,0.0022516005975125,2.64750864476206,1.98635523014012,127.719946645636,0.0009101752788745,"lineage2","dr_mutations_pyrazinamide","GLY",0,"ERR2517032","ERR2517032","lineage2.2.1","gb","UK","pnca_p.val44gly","A","E","VAL","VA44","pnca_complex.pdb"
|
|
"V44G","L2","PZA","V","V44",44,"G",1,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",17.073,-1.136,-2.975,5.19527,-3.88,-2.43,74,85,-0.194,6,6,13,0.0747126436781609,"strand",1.73333333333333,5.57,0.0005030904125341,12.1451137320977,12.1450773794064,12.1416664151504,11.0019205274607,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-2,0,-2,0,4,0,5,19,-0.28774062816616,-0.768733850129199,0.18922304212589,-0.6615515771526,-0.636125654450262,0.778947368421053,-0.159802306425041,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.411,-0.038,"7:5","149/150","T:A:Q:C:R:I:L:V",2.4969239337312,0.0028293218857323,0.83629495944555,2.98569769616526,2.61610833082893,84.8371270838078,1.08440158608155,0.0022516005975125,2.64750864476206,1.98635523014012,127.719946645636,0.0009101752788745,"lineage2","dr_mutations_pyrazinamide","GLY",0,"ERS457694,SAMEA2534292","ERR551922_ERR551923","lineage2.2.1","uz","Nukus","pnca_p.val44gly","A","E","VAL","VA44","pnca_complex.pdb"
|
|
"V44G","L2","PZA","V","V44",44,"G",0,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",17.073,-1.136,-2.975,5.19527,-3.88,-2.43,74,85,-0.194,6,6,13,0.0747126436781609,"strand",1.73333333333333,5.57,0.0005030904125341,12.1451137320977,12.1450773794064,12.1416664151504,11.0019205274607,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-2,0,-2,0,4,0,5,19,-0.28774062816616,-0.768733850129199,0.18922304212589,-0.6615515771526,-0.636125654450262,0.778947368421053,-0.159802306425041,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.411,-0.038,"7:5","149/150","T:A:Q:C:R:I:L:V",2.4969239337312,0.0028293218857323,0.83629495944555,2.98569769616526,2.61610833082893,84.8371270838078,1.08440158608155,0.0022516005975125,2.64750864476206,1.98635523014012,127.719946645636,0.0009101752788745,"lineage2","dr_mutations_pyrazinamide","GLY",0,"ERR019552","ERR019552","lineage2.2.1","ru","Russia","pnca_p.val44gly","A","E","VAL","VA44","pnca_complex.pdb"
|
|
"V44G","L2","PZA","V","V44",44,"G",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",17.073,-1.136,-2.975,5.19527,-3.88,-2.43,74,85,-0.194,6,6,13,0.0747126436781609,"strand",1.73333333333333,5.57,0.0005030904125341,12.1451137320977,12.1450773794064,12.1416664151504,11.0019205274607,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-2,0,-2,0,4,0,5,19,-0.28774062816616,-0.768733850129199,0.18922304212589,-0.6615515771526,-0.636125654450262,0.778947368421053,-0.159802306425041,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.411,-0.038,"7:5","149/150","T:A:Q:C:R:I:L:V",2.4969239337312,0.0028293218857323,0.83629495944555,2.98569769616526,2.61610833082893,84.8371270838078,1.08440158608155,0.0022516005975125,2.64750864476206,1.98635523014012,127.719946645636,0.0009101752788745,"lineage2","dr_mutations_pyrazinamide","GLY",0,"SRS936019,SAMN03653286","SRR2024986","lineage2.2.1.1","cn","China","pnca_p.val44gly","A","E","VAL","VA44","pnca_complex.pdb"
|
|
"V44G","L4","PZA","V","V44",44,"G",1,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",17.073,-1.136,-2.975,5.19527,-3.88,-2.43,74,85,-0.194,6,6,13,0.0747126436781609,"strand",1.73333333333333,5.57,0.0005030904125341,12.1451137320977,12.1450773794064,12.1416664151504,11.0019205274607,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-2,0,-2,0,4,0,5,19,-0.28774062816616,-0.768733850129199,0.18922304212589,-0.6615515771526,-0.636125654450262,0.778947368421053,-0.159802306425041,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.411,-0.038,"7:5","149/150","T:A:Q:C:R:I:L:V",2.4969239337312,0.0028293218857323,0.83629495944555,2.98569769616526,2.61610833082893,84.8371270838078,1.08440158608155,0.0022516005975125,2.64750864476206,1.98635523014012,127.719946645636,0.0009101752788745,"lineage4","dr_mutations_pyrazinamide","GLY",0,"2092A-sc-2012-04-10T09:16:12Z-1397791,ERR158579","ERR158579","lineage4.3.3","ru","Russia,Samara","pnca_p.val44gly","A","E","VAL","VA44","pnca_complex.pdb"
|
|
"V44G","L2","PZA","V","V44",44,"G",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",17.073,-1.136,-2.975,5.19527,-3.88,-2.43,74,85,-0.194,6,6,13,0.0747126436781609,"strand",1.73333333333333,5.57,0.0005030904125341,12.1451137320977,12.1450773794064,12.1416664151504,11.0019205274607,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-2,0,-2,0,4,0,5,19,-0.28774062816616,-0.768733850129199,0.18922304212589,-0.6615515771526,-0.636125654450262,0.778947368421053,-0.159802306425041,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.411,-0.038,"7:5","149/150","T:A:Q:C:R:I:L:V",2.4969239337312,0.0028293218857323,0.83629495944555,2.98569769616526,2.61610833082893,84.8371270838078,1.08440158608155,0.0022516005975125,2.64750864476206,1.98635523014012,127.719946645636,0.0009101752788745,"lineage2","dr_mutations_pyrazinamide","GLY",0,"SAMN03653280,SRS936025","SRR2024980","lineage2.2.1.1","cn","China","pnca_p.val44gly","A","E","VAL","VA44","pnca_complex.pdb"
|
|
"V44G","L2","PZA","V","V44",44,"G",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",17.073,-1.136,-2.975,5.19527,-3.88,-2.43,74,85,-0.194,6,6,13,0.0747126436781609,"strand",1.73333333333333,5.57,0.0005030904125341,12.1451137320977,12.1450773794064,12.1416664151504,11.0019205274607,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-2,0,-2,0,4,0,5,19,-0.28774062816616,-0.768733850129199,0.18922304212589,-0.6615515771526,-0.636125654450262,0.778947368421053,-0.159802306425041,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.411,-0.038,"7:5","149/150","T:A:Q:C:R:I:L:V",2.4969239337312,0.0028293218857323,0.83629495944555,2.98569769616526,2.61610833082893,84.8371270838078,1.08440158608155,0.0022516005975125,2.64750864476206,1.98635523014012,127.719946645636,0.0009101752788745,"lineage2","dr_mutations_pyrazinamide","GLY",0,"SRR5709948","SRR5709948","lineage2.2.1","th","Thailand","pnca_p.val44gly","A","E","VAL","VA44","pnca_complex.pdb"
|
|
"V44G","L2","PZA","V","V44",44,"G",0,"XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",17.073,-1.136,-2.975,5.19527,-3.88,-2.43,74,85,-0.194,6,6,13,0.0747126436781609,"strand",1.73333333333333,5.57,0.0005030904125341,12.1451137320977,12.1450773794064,12.1416664151504,11.0019205274607,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-2,0,-2,0,4,0,5,19,-0.28774062816616,-0.768733850129199,0.18922304212589,-0.6615515771526,-0.636125654450262,0.778947368421053,-0.159802306425041,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.411,-0.038,"7:5","149/150","T:A:Q:C:R:I:L:V",2.4969239337312,0.0028293218857323,0.83629495944555,2.98569769616526,2.61610833082893,84.8371270838078,1.08440158608155,0.0022516005975125,2.64750864476206,1.98635523014012,127.719946645636,0.0009101752788745,"lineage2","dr_mutations_pyrazinamide","GLY",0,"ERR2516779","ERR2516779","lineage2.2.1","gb","UK","pnca_p.val44gly","A","E","VAL","VA44","pnca_complex.pdb"
|
|
"V44G","L2","PZA","V","V44",44,"G",NA,"XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",17.073,-1.136,-2.975,5.19527,-3.88,-2.43,74,85,-0.194,6,6,13,0.0747126436781609,"strand",1.73333333333333,5.57,0.0005030904125341,12.1451137320977,12.1450773794064,12.1416664151504,11.0019205274607,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-2,0,-2,0,4,0,5,19,-0.28774062816616,-0.768733850129199,0.18922304212589,-0.6615515771526,-0.636125654450262,0.778947368421053,-0.159802306425041,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.411,-0.038,"7:5","149/150","T:A:Q:C:R:I:L:V",2.4969239337312,0.0028293218857323,0.83629495944555,2.98569769616526,2.61610833082893,84.8371270838078,1.08440158608155,0.0022516005975125,2.64750864476206,1.98635523014012,127.719946645636,0.0009101752788745,"lineage2","dr_mutations_pyrazinamide","GLY",0,"ERR1035098","ERR1035098","lineage2.2.1","vn","Vietnam","pnca_p.val44gly","A","E","VAL","VA44","pnca_complex.pdb"
|
|
"V45A","L2","PZA","V","V45",45,"A",0,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",13.521,-2.228,-2.783,3.60576,-1.973,-2.23,39,66,-0.375,6,6,0,0,"strand",3.4,8.66,7.18700589334483e-05,2.42412778478352,0.0001249735077034,0,1.03410070803344e-29,6,2,0,0,2,0,0,0,0,0,0,0,0,0,0,0,0,2,0,0,1,2,0,0,7,-0.564336372847011,-0.719121447028424,0.131329627983887,-0.336402387041773,-0.583769633507853,0.410526315789474,-0.308896210873147,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.553,-0.244,"7:6","149/150","F:A:Y:M:I:V:L",-8.98740878149641,0.940032862253633,119.46804443549,-0.0752285585987758,NA,4692673.5108122,0.384555509373631,1,0,0,188.544222231268,0.999999999999997,"lineage2","other_mutations_pyrazinamide","ALA",0,"SAMEA2534091,ERS457493","ERR551648_ERR551649","lineage2.2.1","uz","Nukus","pnca_p.val45ala","A","E","VAL","VA45","pnca_complex.pdb"
|
|
"V45E","L2","PZA","V","V45",45,"E",NA,"Pre-XDR","OM","hydrophobic","hydrophilic","non-polar","acidic","non-polar","neg",13.521,-1.593,-3.389,4.70839,-4.817,-1.92,80,91,-0.375,6,6,0,0,"strand",3.4,8.66,NA,NA,NA,NA,NA,-32,-34,0,-2,-32,0,0,0,0,0,0,0,0,0,0,0,0,2,0,2,-1,0,0,0,0,-0.403495440729483,-0.875710594315245,0.171489812717167,-0.821312872975277,-0.50261780104712,0.842105263157895,-0.308896210873147,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.553,-0.244,"7:6","149/150","F:A:Y:M:I:V:L",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage2","other_mutations_pyrazinamide","GLU",0,"SAMN02360628","SRR1003108_SRR1003107","lineage2.2.1","kr","South Korea","pnca_p.val45glu","A","E","VAL","VA45","pnca_complex.pdb"
|
|
"V45E","L2","PZA","V","V45",45,"E",NA,"Pre-XDR","OM","hydrophobic","hydrophilic","non-polar","acidic","non-polar","neg",13.521,-1.593,-3.389,4.70839,-4.817,-1.92,80,91,-0.375,6,6,0,0,"strand",3.4,8.66,NA,NA,NA,NA,NA,-32,-34,0,-2,-32,0,0,0,0,0,0,0,0,0,0,0,0,2,0,2,-1,0,0,0,0,-0.403495440729483,-0.875710594315245,0.171489812717167,-0.821312872975277,-0.50261780104712,0.842105263157895,-0.308896210873147,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.553,-0.244,"7:6","149/150","F:A:Y:M:I:V:L",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage2","other_mutations_pyrazinamide","GLU",0,"SAMN02360625","SRR1048184_SRR1003101","lineage2.2.1","kr","South Korea","pnca_p.val45glu","A","E","VAL","VA45","pnca_complex.pdb"
|
|
"V45E","L2","PZA","V","V45",45,"E",NA,"Pre-XDR","OM","hydrophobic","hydrophilic","non-polar","acidic","non-polar","neg",13.521,-1.593,-3.389,4.70839,-4.817,-1.92,80,91,-0.375,6,6,0,0,"strand",3.4,8.66,NA,NA,NA,NA,NA,-32,-34,0,-2,-32,0,0,0,0,0,0,0,0,0,0,0,0,2,0,2,-1,0,0,0,0,-0.403495440729483,-0.875710594315245,0.171489812717167,-0.821312872975277,-0.50261780104712,0.842105263157895,-0.308896210873147,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.553,-0.244,"7:6","149/150","F:A:Y:M:I:V:L",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage2","other_mutations_pyrazinamide","GLU",0,"SAMN02360550","SRR1048841_SRR1013541_SRR1048840_SRR1013542","lineage2.2.1","kr","South Korea","pnca_p.val45glu","A","E","VAL","VA45","pnca_complex.pdb"
|
|
"V45G","L3","PZA","V","V45",45,"G",0,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",13.521,-1.938,-3.523,5.16465,-3.509,-3.55,80,91,-0.375,6,6,0,0,"strand",3.4,8.66,7.18700589334483e-05,2.42412778478352,0.0001249735077034,0,1.03410070803344e-29,10,2,0,0,2,0,0,0,0,0,0,0,0,0,0,0,0,4,0,2,1,4,0,5,25,-0.490881458966565,-0.910335917312662,0.188107795074265,-0.598294970161978,-0.929319371727749,0.842105263157895,-0.308896210873147,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.553,-0.244,"7:6","149/150","F:A:Y:M:I:V:L",-8.98740878149642,0.940032862253634,119.468044435493,-0.0752285585987741,NA,4692673.51081481,0.384555509373631,1,0,0,188.544222231268,0.999999999999997,"lineage3","dr_mutations_pyrazinamide","GLY",0,"ERR2510298","ERR2510298","lineage3","pk","Pakistan","pnca_p.val45gly","A","E","VAL","VA45","pnca_complex.pdb"
|
|
"A46E","L2","PZA","A","A46",46,"E",1,"Pre-XDR","DM","hydrophobic","hydrophilic","non-polar","acidic","non-polar","neg",11.322,-1.749,-1.747,2.18089,-5.096,-1.21,79,85,-0.822,8,8,0,0,"strand",1.76666666666667,8.13,7.18700589334483e-05,9.70142977291842,188179.926264417,Inf,0.763784339928386,-36,-32,0,0,-32,0,0,0,0,0,0,0,0,0,0,0,0,-4,0,1,-5,-8,0,-8,-7,-0.443009118541033,-0.451421188630491,0.0794327610195296,-0.868883205456095,-0.316753926701571,0.831578947368421,-0.677100494233937,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.914,-0.779,"8:8","149/150","Q:F:Y:I:V:L:T:A:S:G",12.1451538387253,0.919026337424195,119.468044436163,0.101660271548305,5.01153666069207e-06,NA,0.986835744238421,0.170978870202674,0.767057556984365,0.124324963210678,Inf,0.382146811758261,"lineage2","dr_mutations_pyrazinamide","GLU",0,"SRR5817469","SRR5817469","lineage2.2.1","au","Australia","pnca_p.ala46glu","A","E","ALA","AA46","pnca_complex.pdb"
|
|
"A46E","L2","PZA","A","A46",46,"E",NA,"XDR","DM","hydrophobic","hydrophilic","non-polar","acidic","non-polar","neg",11.322,-1.749,-1.747,2.18089,-5.096,-1.21,79,85,-0.822,8,8,0,0,"strand",1.76666666666667,8.13,7.18700589334483e-05,9.70142977291842,188179.926264417,Inf,0.763784339928386,-36,-32,0,0,-32,0,0,0,0,0,0,0,0,0,0,0,0,-4,0,1,-5,-8,0,-8,-7,-0.443009118541033,-0.451421188630491,0.0794327610195296,-0.868883205456095,-0.316753926701571,0.831578947368421,-0.677100494233937,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.914,-0.779,"8:8","149/150","Q:F:Y:I:V:L:T:A:S:G",12.1451538387253,0.919026337424195,119.468044436163,0.101660271548305,5.01153666069207e-06,NA,0.986835744238421,0.170978870202674,0.767057556984365,0.124324963210678,Inf,0.382146811758261,"lineage2","dr_mutations_pyrazinamide","GLU",0,"BGI_LN023,SRR671781","SRR671781","lineage2.2.1","cn","China","pnca_p.ala46glu","A","E","ALA","AA46","pnca_complex.pdb"
|
|
"A46P","L2","PZA","A","A46",46,"P",1,"XDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",11.322,-2.408,-0.221,2.09234,-4.42,0.65,81,91,-0.822,8,8,0,0,"strand",1.76666666666667,8.13,0.0001437401178668,19.411022297013,511754.463552641,Inf,4.73122070382274,0,0,0,0,0,0,0,0,0,2,2,0,0,0,0,0,0,-10,0,-8,-4,-2,0,0,-3,-0.609929078014184,-0.0571059431524547,0.0762075772696479,-0.753623188405797,0.365168539325843,0.852631578947368,-0.677100494233937,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.914,-0.779,"8:8","149/150","Q:F:Y:I:V:L:T:A:S:G",13.1456002256206,0.924803768447002,139.277183326574,0.0943844491369209,0.0001628371344451,NA,1.28804840845689,0.0292235860951597,1.53426649183163,0.91081598550184,Inf,0.0296198560706035,"lineage2","dr_mutations_pyrazinamide","PRO",0,"TB-17","ERR2851370","lineage2.2.1","lb","Lebanon","pnca_p.ala46pro","A","E","ALA","AA46","pnca_complex.pdb"
|
|
"A46P","L4","PZA","A","A46",46,"P",1,"Pre-XDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",11.322,-2.408,-0.221,2.09234,-4.42,0.65,81,91,-0.822,8,8,0,0,"strand",1.76666666666667,8.13,0.0001437401178668,19.411022297013,511754.463552641,Inf,4.73122070382274,0,0,0,0,0,0,0,0,0,2,2,0,0,0,0,0,0,-10,0,-8,-4,-2,0,0,-3,-0.609929078014184,-0.0571059431524547,0.0762075772696479,-0.753623188405797,0.365168539325843,0.852631578947368,-0.677100494233937,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.914,-0.779,"8:8","149/150","Q:F:Y:I:V:L:T:A:S:G",13.1456002256206,0.924803768447002,139.277183326574,0.0943844491369209,0.0001628371344451,NA,1.28804840845689,0.0292235860951597,1.53426649183163,0.91081598550184,Inf,0.0296198560706035,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR1034996","ERR1034996","lineage4.3.2.1","za","South Africa","pnca_p.ala46pro","A","E","ALA","AA46","pnca_complex.pdb"
|
|
"A46T","L4","PZA","A","A46",46,"T",0,"MDR","OM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",11.322,-1.355,-1.192,-1.34478,-2.283,-0.62,-6,53,-0.822,8,8,0,0,"strand",1.76666666666667,8.13,0.0001437401178668,4.85029436501262,4.85029432717733,4.84956447904112,0.0881192621863332,-2,0,0,0,0,0,0,0,0,-2,0,-2,0,0,0,0,0,-9,0,-2,-7,-2,0,-2,-3,-0.343211752786221,-0.308010335917313,-0.258551872644774,-0.38925831202046,-0.162303664921466,-0.0645161290322581,-0.677100494233937,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","neutral",-0.914,-0.779,"8:8","149/150","Q:F:Y:I:V:L:T:A:S:G",1.57903938912402,0.264247566376724,1.41439286276584,1.11640791656443,0.191756076673846,122.683760398934,0.685768096792206,0.312734154310187,0.504824686014995,0.061763864579114,379.558337204203,0.766581879696361,"lineage4","other_mutations_pyrazinamide","THR",0,"ERR2041741","ERR2041741","lineage4.1.2.1","rs","Serbia","pnca_p.ala46thr","A","E","ALA","AA46","pnca_complex.pdb"
|
|
"A46T","L4","PZA","A","A46",46,"T",1,"XDR","OM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",11.322,-1.355,-1.192,-1.34478,-2.283,-0.62,-6,53,-0.822,8,8,0,0,"strand",1.76666666666667,8.13,0.0001437401178668,4.85029436501262,4.85029432717733,4.84956447904112,0.0881192621863332,-2,0,0,0,0,0,0,0,0,-2,0,-2,0,0,0,0,0,-9,0,-2,-7,-2,0,-2,-3,-0.343211752786221,-0.308010335917313,-0.258551872644774,-0.38925831202046,-0.162303664921466,-0.0645161290322581,-0.677100494233937,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","neutral",-0.914,-0.779,"8:8","149/150","Q:F:Y:I:V:L:T:A:S:G",1.57903938912402,0.264247566376724,1.41439286276584,1.11640791656443,0.191756076673846,122.683760398934,0.685768096792206,0.312734154310187,0.504824686014995,0.061763864579114,379.558337204203,0.766581879696361,"lineage4","other_mutations_pyrazinamide","THR",0,"ERR2510867","ERR2510867","lineage4.1.2.1","it","Italy","pnca_p.ala46thr","A","E","ALA","AA46","pnca_complex.pdb"
|
|
"A46V","L5","PZA","A","A46",46,"V",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",11.322,-2.718,1.017,-2.38862,-1.487,0.44,59,75,-0.822,8,8,0,0,"strand",1.76666666666667,8.13,0.0004312203536006,9.712,9.7119892297561,9.70929820233251,7.20065367726982,-2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,1,-8,-2,0,2,-7,-0.688449848024316,0.864795918367347,-0.459244020610628,-0.253537936913896,0.247191011235955,0.621052631578947,-0.677100494233937,"Destabilising","Stabilising","Stabilising","Destabilising","Stabilising","effect",-0.914,-0.779,"8:8","149/150","Q:F:Y:I:V:L:T:A:S:G",2.27336112535402,0.0086576033028962,0.865947753893075,2.62528670480821,1.89450831676925,70.0912742677304,0.987308673731182,0.0095462527031996,2.02016707341074,1.39065774214338,107.435987551185,0.0072877030810549,"lineage5","dr_mutations_pyrazinamide","VAL",0,"ERR502508","ERR502508","lineage5","gh","Ghana","pnca_p.ala46val","A","E","ALA","AA46","pnca_complex.pdb"
|
|
"A46V","L4","PZA","A","A46",46,"V",1,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",11.322,-2.718,1.017,-2.38862,-1.487,0.44,59,75,-0.822,8,8,0,0,"strand",1.76666666666667,8.13,0.0004312203536006,9.712,9.7119892297561,9.70929820233251,7.20065367726982,-2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,1,-8,-2,0,2,-7,-0.688449848024316,0.864795918367347,-0.459244020610628,-0.253537936913896,0.247191011235955,0.621052631578947,-0.677100494233937,"Destabilising","Stabilising","Stabilising","Destabilising","Stabilising","effect",-0.914,-0.779,"8:8","149/150","Q:F:Y:I:V:L:T:A:S:G",2.27336112535402,0.0086576033028962,0.865947753893075,2.62528670480821,1.89450831676925,70.0912742677304,0.987308673731182,0.0095462527031996,2.02016707341074,1.39065774214338,107.435987551185,0.0072877030810549,"lineage4","dr_mutations_pyrazinamide","VAL",0,"SAMN10961376","SRR8651617","lineage4.5","cn","China:Wenzhou","pnca_p.ala46val","A","E","ALA","AA46","pnca_complex.pdb"
|
|
"A46V","L2","PZA","A","A46",46,"V",1,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",11.322,-2.718,1.017,-2.38862,-1.487,0.44,59,75,-0.822,8,8,0,0,"strand",1.76666666666667,8.13,0.0004312203536006,9.712,9.7119892297561,9.70929820233251,7.20065367726982,-2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,1,-8,-2,0,2,-7,-0.688449848024316,0.864795918367347,-0.459244020610628,-0.253537936913896,0.247191011235955,0.621052631578947,-0.677100494233937,"Destabilising","Stabilising","Stabilising","Destabilising","Stabilising","effect",-0.914,-0.779,"8:8","149/150","Q:F:Y:I:V:L:T:A:S:G",2.27336112535402,0.0086576033028962,0.865947753893075,2.62528670480821,1.89450831676925,70.0912742677304,0.987308673731182,0.0095462527031996,2.02016707341074,1.39065774214338,107.435987551185,0.0072877030810549,"lineage2","dr_mutations_pyrazinamide","VAL",0,"ERS2592751","ERR2677402","lineage2.2.1","de","Germany","pnca_p.ala46val","A","E","ALA","AA46","pnca_complex.pdb"
|
|
"A46V","L4","PZA","A","A46",46,"V",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",11.322,-2.718,1.017,-2.38862,-1.487,0.44,59,75,-0.822,8,8,0,0,"strand",1.76666666666667,8.13,0.0004312203536006,9.712,9.7119892297561,9.70929820233251,7.20065367726982,-2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,1,-8,-2,0,2,-7,-0.688449848024316,0.864795918367347,-0.459244020610628,-0.253537936913896,0.247191011235955,0.621052631578947,-0.677100494233937,"Destabilising","Stabilising","Stabilising","Destabilising","Stabilising","effect",-0.914,-0.779,"8:8","149/150","Q:F:Y:I:V:L:T:A:S:G",2.27336112535402,0.0086576033028962,0.865947753893075,2.62528670480821,1.89450831676925,70.0912742677304,0.987308673731182,0.0095462527031996,2.02016707341074,1.39065774214338,107.435987551185,0.0072877030810549,"lineage4","dr_mutations_pyrazinamide","VAL",0,"SAMN02403571","SRR1169134_SRR1172080_SRR1165618_SRR1167371","lineage4.3.3","za","South Africa","pnca_p.ala46val","A","E","ALA","AA46","pnca_complex.pdb"
|
|
"A46V","L2","PZA","A","A46",46,"V",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",11.322,-2.718,1.017,-2.38862,-1.487,0.44,59,75,-0.822,8,8,0,0,"strand",1.76666666666667,8.13,0.0004312203536006,9.712,9.7119892297561,9.70929820233251,7.20065367726982,-2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,1,-8,-2,0,2,-7,-0.688449848024316,0.864795918367347,-0.459244020610628,-0.253537936913896,0.247191011235955,0.621052631578947,-0.677100494233937,"Destabilising","Stabilising","Stabilising","Destabilising","Stabilising","effect",-0.914,-0.779,"8:8","149/150","Q:F:Y:I:V:L:T:A:S:G",2.27336112535402,0.0086576033028962,0.865947753893075,2.62528670480821,1.89450831676925,70.0912742677304,0.987308673731182,0.0095462527031996,2.02016707341074,1.39065774214338,107.435987551185,0.0072877030810549,"lineage2","dr_mutations_pyrazinamide","VAL",0,"DRR185078","DRR185078","lineage2.2.1.1","vn","Vietnam","pnca_p.ala46val","A","E","ALA","AA46","pnca_complex.pdb"
|
|
"A46V","L5","PZA","A","A46",46,"V",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",11.322,-2.718,1.017,-2.38862,-1.487,0.44,59,75,-0.822,8,8,0,0,"strand",1.76666666666667,8.13,0.0004312203536006,9.712,9.7119892297561,9.70929820233251,7.20065367726982,-2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,1,-8,-2,0,2,-7,-0.688449848024316,0.864795918367347,-0.459244020610628,-0.253537936913896,0.247191011235955,0.621052631578947,-0.677100494233937,"Destabilising","Stabilising","Stabilising","Destabilising","Stabilising","effect",-0.914,-0.779,"8:8","149/150","Q:F:Y:I:V:L:T:A:S:G",2.27336112535402,0.0086576033028962,0.865947753893075,2.62528670480821,1.89450831676925,70.0912742677304,0.987308673731182,0.0095462527031996,2.02016707341074,1.39065774214338,107.435987551185,0.0072877030810549,"lineage5","dr_mutations_pyrazinamide","VAL",0,"ERR502509","ERR502509","lineage5","gh","Ghana","pnca_p.ala46val","A","E","ALA","AA46","pnca_complex.pdb"
|
|
"A46V","L4","PZA","A","A46",46,"V",0,"Pre-MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",11.322,-2.718,1.017,-2.38862,-1.487,0.44,59,75,-0.822,8,8,0,0,"strand",1.76666666666667,8.13,0.0004312203536006,9.712,9.7119892297561,9.70929820233251,7.20065367726982,-2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,1,-8,-2,0,2,-7,-0.688449848024316,0.864795918367347,-0.459244020610628,-0.253537936913896,0.247191011235955,0.621052631578947,-0.677100494233937,"Destabilising","Stabilising","Stabilising","Destabilising","Stabilising","effect",-0.914,-0.779,"8:8","149/150","Q:F:Y:I:V:L:T:A:S:G",2.27336112535402,0.0086576033028962,0.865947753893075,2.62528670480821,1.89450831676925,70.0912742677304,0.987308673731182,0.0095462527031996,2.02016707341074,1.39065774214338,107.435987551185,0.0072877030810549,"lineage4","dr_mutations_pyrazinamide","VAL",0,"1507P-sc-2012-10-11T13:37:39Z-1494154,ERR227990","ERR227990","lineage4.3.3","ru","Russia","pnca_p.ala46val","A","E","ALA","AA46","pnca_complex.pdb"
|
|
"A46V","L2","PZA","A","A46",46,"V",0,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",11.322,-2.718,1.017,-2.38862,-1.487,0.44,59,75,-0.822,8,8,0,0,"strand",1.76666666666667,8.13,0.0004312203536006,9.712,9.7119892297561,9.70929820233251,7.20065367726982,-2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,1,-8,-2,0,2,-7,-0.688449848024316,0.864795918367347,-0.459244020610628,-0.253537936913896,0.247191011235955,0.621052631578947,-0.677100494233937,"Destabilising","Stabilising","Stabilising","Destabilising","Stabilising","effect",-0.914,-0.779,"8:8","149/150","Q:F:Y:I:V:L:T:A:S:G",2.27336112535402,0.0086576033028962,0.865947753893075,2.62528670480821,1.89450831676925,70.0912742677304,0.987308673731182,0.0095462527031996,2.02016707341074,1.39065774214338,107.435987551185,0.0072877030810549,"lineage2","dr_mutations_pyrazinamide","VAL",0,"ERS457791,SAMEA2534389","ERR552064_ERR552065","lineage2.2.1","uz","Nukus","pnca_p.ala46val","A","E","ALA","AA46","pnca_complex.pdb"
|
|
"A46V","L2","PZA","A","A46",46,"V",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",11.322,-2.718,1.017,-2.38862,-1.487,0.44,59,75,-0.822,8,8,0,0,"strand",1.76666666666667,8.13,0.0004312203536006,9.712,9.7119892297561,9.70929820233251,7.20065367726982,-2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,1,-8,-2,0,2,-7,-0.688449848024316,0.864795918367347,-0.459244020610628,-0.253537936913896,0.247191011235955,0.621052631578947,-0.677100494233937,"Destabilising","Stabilising","Stabilising","Destabilising","Stabilising","effect",-0.914,-0.779,"8:8","149/150","Q:F:Y:I:V:L:T:A:S:G",2.27336112535402,0.0086576033028962,0.865947753893075,2.62528670480821,1.89450831676925,70.0912742677304,0.987308673731182,0.0095462527031996,2.02016707341074,1.39065774214338,107.435987551185,0.0072877030810549,"lineage2","dr_mutations_pyrazinamide","VAL",0,"ERR3276241","ERR3276241","lineage2.2.1","nl","Netherlands","pnca_p.ala46val","A","E","ALA","AA46","pnca_complex.pdb"
|
|
"A46V","L4","PZA","A","A46",46,"V",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",11.322,-2.718,1.017,-2.38862,-1.487,0.44,59,75,-0.822,8,8,0,0,"strand",1.76666666666667,8.13,0.0004312203536006,9.712,9.7119892297561,9.70929820233251,7.20065367726982,-2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,1,-8,-2,0,2,-7,-0.688449848024316,0.864795918367347,-0.459244020610628,-0.253537936913896,0.247191011235955,0.621052631578947,-0.677100494233937,"Destabilising","Stabilising","Stabilising","Destabilising","Stabilising","effect",-0.914,-0.779,"8:8","149/150","Q:F:Y:I:V:L:T:A:S:G",2.27336112535402,0.0086576033028962,0.865947753893075,2.62528670480821,1.89450831676925,70.0912742677304,0.987308673731182,0.0095462527031996,2.02016707341074,1.39065774214338,107.435987551185,0.0072877030810549,"lineage4","dr_mutations_pyrazinamide","VAL",0,"ERR2510135","ERR2510135","lineage4.1.2.1","pe","Peru","pnca_p.ala46val","A","E","ALA","AA46","pnca_complex.pdb"
|
|
"A46V","L4","PZA","A","A46",46,"V",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",11.322,-2.718,1.017,-2.38862,-1.487,0.44,59,75,-0.822,8,8,0,0,"strand",1.76666666666667,8.13,0.0004312203536006,9.712,9.7119892297561,9.70929820233251,7.20065367726982,-2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,1,-8,-2,0,2,-7,-0.688449848024316,0.864795918367347,-0.459244020610628,-0.253537936913896,0.247191011235955,0.621052631578947,-0.677100494233937,"Destabilising","Stabilising","Stabilising","Destabilising","Stabilising","effect",-0.914,-0.779,"8:8","149/150","Q:F:Y:I:V:L:T:A:S:G",2.27336112535402,0.0086576033028962,0.865947753893075,2.62528670480821,1.89450831676925,70.0912742677304,0.987308673731182,0.0095462527031996,2.02016707341074,1.39065774214338,107.435987551185,0.0072877030810549,"lineage4","dr_mutations_pyrazinamide","VAL",0,"ERR775335","ERR775335","lineage4.1.2.1","pe","","pnca_p.ala46val","A","E","ALA","AA46","pnca_complex.pdb"
|
|
"A46V","L1","PZA","A","A46",46,"V",NA,"XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",11.322,-2.718,1.017,-2.38862,-1.487,0.44,59,75,-0.822,8,8,0,0,"strand",1.76666666666667,8.13,0.0004312203536006,9.712,9.7119892297561,9.70929820233251,7.20065367726982,-2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,1,-8,-2,0,2,-7,-0.688449848024316,0.864795918367347,-0.459244020610628,-0.253537936913896,0.247191011235955,0.621052631578947,-0.677100494233937,"Destabilising","Stabilising","Stabilising","Destabilising","Stabilising","effect",-0.914,-0.779,"8:8","149/150","Q:F:Y:I:V:L:T:A:S:G",2.27336112535402,0.0086576033028962,0.865947753893075,2.62528670480821,1.89450831676925,70.0912742677304,0.987308673731182,0.0095462527031996,2.02016707341074,1.39065774214338,107.435987551185,0.0072877030810549,"lineage1","dr_mutations_pyrazinamide","VAL",0,"SRR7898227","SRR7898227","lineage1.1.2","in","India","pnca_p.ala46val","A","E","ALA","AA46","pnca_complex.pdb"
|
|
"A46V","L4","PZA","A","A46",46,"V",NA,"XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",11.322,-2.718,1.017,-2.38862,-1.487,0.44,59,75,-0.822,8,8,0,0,"strand",1.76666666666667,8.13,0.0004312203536006,9.712,9.7119892297561,9.70929820233251,7.20065367726982,-2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,1,-8,-2,0,2,-7,-0.688449848024316,0.864795918367347,-0.459244020610628,-0.253537936913896,0.247191011235955,0.621052631578947,-0.677100494233937,"Destabilising","Stabilising","Stabilising","Destabilising","Stabilising","effect",-0.914,-0.779,"8:8","149/150","Q:F:Y:I:V:L:T:A:S:G",2.27336112535402,0.0086576033028962,0.865947753893075,2.62528670480821,1.89450831676925,70.0912742677304,0.987308673731182,0.0095462527031996,2.02016707341074,1.39065774214338,107.435987551185,0.0072877030810549,"lineage4","dr_mutations_pyrazinamide","VAL",0,"SAMN02419566","SRR1183966_SRR1180970_SRR1162534_SRR1159299","lineage4.1.2.1","by","Belarus","pnca_p.ala46val","A","E","ALA","AA46","pnca_complex.pdb"
|
|
"A46V","L4","PZA","A","A46",46,"V",1,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",11.322,-2.718,1.017,-2.38862,-1.487,0.44,59,75,-0.822,8,8,0,0,"strand",1.76666666666667,8.13,0.0004312203536006,9.712,9.7119892297561,9.70929820233251,7.20065367726982,-2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,1,-8,-2,0,2,-7,-0.688449848024316,0.864795918367347,-0.459244020610628,-0.253537936913896,0.247191011235955,0.621052631578947,-0.677100494233937,"Destabilising","Stabilising","Stabilising","Destabilising","Stabilising","effect",-0.914,-0.779,"8:8","149/150","Q:F:Y:I:V:L:T:A:S:G",2.27336112535402,0.0086576033028962,0.865947753893075,2.62528670480821,1.89450831676925,70.0912742677304,0.987308673731182,0.0095462527031996,2.02016707341074,1.39065774214338,107.435987551185,0.0072877030810549,"lineage4","dr_mutations_pyrazinamide","VAL",0,"ERR2516682","ERR2516682","lineage4.3.4.2","pe","Peru","pnca_p.ala46val","A","E","ALA","AA46","pnca_complex.pdb"
|
|
"A46V","L4","PZA","A","A46",46,"V",1,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",11.322,-2.718,1.017,-2.38862,-1.487,0.44,59,75,-0.822,8,8,0,0,"strand",1.76666666666667,8.13,0.0004312203536006,9.712,9.7119892297561,9.70929820233251,7.20065367726982,-2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,1,-8,-2,0,2,-7,-0.688449848024316,0.864795918367347,-0.459244020610628,-0.253537936913896,0.247191011235955,0.621052631578947,-0.677100494233937,"Destabilising","Stabilising","Stabilising","Destabilising","Stabilising","effect",-0.914,-0.779,"8:8","149/150","Q:F:Y:I:V:L:T:A:S:G",2.27336112535402,0.0086576033028962,0.865947753893075,2.62528670480821,1.89450831676925,70.0912742677304,0.987308673731182,0.0095462527031996,2.02016707341074,1.39065774214338,107.435987551185,0.0072877030810549,"lineage4","dr_mutations_pyrazinamide","VAL",0,"ERR2516554","ERR2516554","lineage4.3.4.2","pe","Peru","pnca_p.ala46val","A","E","ALA","AA46","pnca_complex.pdb"
|
|
"T47A","L2","PZA","T","T47",47,"A",1,"Pre-XDR","DM","hydrophobic","hydrophobic","neutral","non-polar","polar","non-polar",7.503,-2.172,-1.71,2.87617,-2.276,-0.77,58,75,-0.925,8,8,0,0,"strand",-0.933333333333333,10.3,0.0008624407072013,4.85840707964602,4.85840704522462,4.85767795624558,6.99654790120219,4,0,0,0,0,0,0,0,0,0,0,0,2,0,0,0,0,6,0,4,2,12,0,6,9,-0.550151975683891,-0.441860465116279,0.10475637205982,-0.388064791133845,-0.201570680628272,0.610526315789474,-0.761943986820428,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.028,-0.872,"9:8","149/150","C:K:I:T:S",1.58071061571228,0.0062231325401172,0.577790125858072,2.73578682807148,1.51864513964879,15.5428887748675,0.686493900966672,0.0089768751657447,2.04687481416212,1.29740576993775,18.1865471788576,0.0081667056971109,"lineage2","dr_mutations_pyrazinamide","ALA",0,"2564N-sc-2012-10-11T13:40:44Z-1494346,ERR234668","ERR234668","lineage2.2.1","ru","Russia,Samara","pnca_p.thr47ala","A","E","THR","TA47","pnca_complex.pdb"
|
|
"T47A","L2","PZA","T","T47",47,"A",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","neutral","non-polar","polar","non-polar",7.503,-2.172,-1.71,2.87617,-2.276,-0.77,58,75,-0.925,8,8,0,0,"strand",-0.933333333333333,10.3,0.0008624407072013,4.85840707964602,4.85840704522462,4.85767795624558,6.99654790120219,4,0,0,0,0,0,0,0,0,0,0,0,2,0,0,0,0,6,0,4,2,12,0,6,9,-0.550151975683891,-0.441860465116279,0.10475637205982,-0.388064791133845,-0.201570680628272,0.610526315789474,-0.761943986820428,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.028,-0.872,"9:8","149/150","C:K:I:T:S",1.58071061571228,0.0062231325401172,0.577790125858072,2.73578682807148,1.51864513964879,15.5428887748675,0.686493900966672,0.0089768751657447,2.04687481416212,1.29740576993775,18.1865471788576,0.0081667056971109,"lineage2","dr_mutations_pyrazinamide","ALA",0,"BGI_GZ10102,SRR671770","SRR671770","lineage2.2.1","cn","China","pnca_p.thr47ala","A","E","THR","TA47","pnca_complex.pdb"
|
|
"T47A","L2","PZA","T","T47",47,"A",0,"Pre-XDR","DM","hydrophobic","hydrophobic","neutral","non-polar","polar","non-polar",7.503,-2.172,-1.71,2.87617,-2.276,-0.77,58,75,-0.925,8,8,0,0,"strand",-0.933333333333333,10.3,0.0008624407072013,4.85840707964602,4.85840704522462,4.85767795624558,6.99654790120219,4,0,0,0,0,0,0,0,0,0,0,0,2,0,0,0,0,6,0,4,2,12,0,6,9,-0.550151975683891,-0.441860465116279,0.10475637205982,-0.388064791133845,-0.201570680628272,0.610526315789474,-0.761943986820428,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.028,-0.872,"9:8","149/150","C:K:I:T:S",1.58071061571228,0.0062231325401172,0.577790125858072,2.73578682807148,1.51864513964879,15.5428887748675,0.686493900966672,0.0089768751657447,2.04687481416212,1.29740576993775,18.1865471788576,0.0081667056971109,"lineage2","dr_mutations_pyrazinamide","ALA",0,"ERR027447","ERR027447","lineage2.2.1","ru","Russia","pnca_p.thr47ala","A","E","THR","TA47","pnca_complex.pdb"
|
|
"T47A","L2","PZA","T","T47",47,"A",NA,"XDR","DM","hydrophobic","hydrophobic","neutral","non-polar","polar","non-polar",7.503,-2.172,-1.71,2.87617,-2.276,-0.77,58,75,-0.925,8,8,0,0,"strand",-0.933333333333333,10.3,0.0008624407072013,4.85840707964602,4.85840704522462,4.85767795624558,6.99654790120219,4,0,0,0,0,0,0,0,0,0,0,0,2,0,0,0,0,6,0,4,2,12,0,6,9,-0.550151975683891,-0.441860465116279,0.10475637205982,-0.388064791133845,-0.201570680628272,0.610526315789474,-0.761943986820428,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.028,-0.872,"9:8","149/150","C:K:I:T:S",1.58071061571228,0.0062231325401172,0.577790125858072,2.73578682807148,1.51864513964879,15.5428887748675,0.686493900966672,0.0089768751657447,2.04687481416212,1.29740576993775,18.1865471788576,0.0081667056971109,"lineage2","dr_mutations_pyrazinamide","ALA",0,"SAMN02414975","SRR1165377_SRR1167114_SRR1162812_SRR1166919","lineage2.2.1","se","Sweden","pnca_p.thr47ala","A","E","THR","TA47","pnca_complex.pdb"
|
|
"T47A","L2","PZA","T","T47",47,"A",NA,"MDR","DM","hydrophobic","hydrophobic","neutral","non-polar","polar","non-polar",7.503,-2.172,-1.71,2.87617,-2.276,-0.77,58,75,-0.925,8,8,0,0,"strand",-0.933333333333333,10.3,0.0008624407072013,4.85840707964602,4.85840704522462,4.85767795624558,6.99654790120219,4,0,0,0,0,0,0,0,0,0,0,0,2,0,0,0,0,6,0,4,2,12,0,6,9,-0.550151975683891,-0.441860465116279,0.10475637205982,-0.388064791133845,-0.201570680628272,0.610526315789474,-0.761943986820428,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.028,-0.872,"9:8","149/150","C:K:I:T:S",1.58071061571228,0.0062231325401172,0.577790125858072,2.73578682807148,1.51864513964879,15.5428887748675,0.686493900966672,0.0089768751657447,2.04687481416212,1.29740576993775,18.1865471788576,0.0081667056971109,"lineage2","dr_mutations_pyrazinamide","ALA",0,"ERR751700","ERR751700","lineage2.2.1","th","Thailand","pnca_p.thr47ala","A","E","THR","TA47","pnca_complex.pdb"
|
|
"T47A","L4","PZA","T","T47",47,"A",1,"XDR","DM","hydrophobic","hydrophobic","neutral","non-polar","polar","non-polar",7.503,-2.172,-1.71,2.87617,-2.276,-0.77,58,75,-0.925,8,8,0,0,"strand",-0.933333333333333,10.3,0.0008624407072013,4.85840707964602,4.85840704522462,4.85767795624558,6.99654790120219,4,0,0,0,0,0,0,0,0,0,0,0,2,0,0,0,0,6,0,4,2,12,0,6,9,-0.550151975683891,-0.441860465116279,0.10475637205982,-0.388064791133845,-0.201570680628272,0.610526315789474,-0.761943986820428,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.028,-0.872,"9:8","149/150","C:K:I:T:S",1.58071061571228,0.0062231325401172,0.577790125858072,2.73578682807148,1.51864513964879,15.5428887748675,0.686493900966672,0.0089768751657447,2.04687481416212,1.29740576993775,18.1865471788576,0.0081667056971109,"lineage4","dr_mutations_pyrazinamide","ALA",0,"ERS2592797","ERR2677452","lineage4.2.1","de","Germany","pnca_p.thr47ala","A","E","THR","TA47","pnca_complex.pdb"
|
|
"T47A","L2","PZA","T","T47",47,"A",0,"Pre-XDR","DM","hydrophobic","hydrophobic","neutral","non-polar","polar","non-polar",7.503,-2.172,-1.71,2.87617,-2.276,-0.77,58,75,-0.925,8,8,0,0,"strand",-0.933333333333333,10.3,0.0008624407072013,4.85840707964602,4.85840704522462,4.85767795624558,6.99654790120219,4,0,0,0,0,0,0,0,0,0,0,0,2,0,0,0,0,6,0,4,2,12,0,6,9,-0.550151975683891,-0.441860465116279,0.10475637205982,-0.388064791133845,-0.201570680628272,0.610526315789474,-0.761943986820428,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.028,-0.872,"9:8","149/150","C:K:I:T:S",1.58071061571228,0.0062231325401172,0.577790125858072,2.73578682807148,1.51864513964879,15.5428887748675,0.686493900966672,0.0089768751657447,2.04687481416212,1.29740576993775,18.1865471788576,0.0081667056971109,"lineage2","dr_mutations_pyrazinamide","ALA",0,"ERR230008,2490H-sc-2012-10-11T13:40:25Z-1494327","ERR230008","lineage2.2.1","ru","Russia,Samara","pnca_p.thr47ala","A","E","THR","TA47","pnca_complex.pdb"
|
|
"T47A","L2","PZA","T","T47",47,"A",0,"XDR","DM","hydrophobic","hydrophobic","neutral","non-polar","polar","non-polar",7.503,-2.172,-1.71,2.87617,-2.276,-0.77,58,75,-0.925,8,8,0,0,"strand",-0.933333333333333,10.3,0.0008624407072013,4.85840707964602,4.85840704522462,4.85767795624558,6.99654790120219,4,0,0,0,0,0,0,0,0,0,0,0,2,0,0,0,0,6,0,4,2,12,0,6,9,-0.550151975683891,-0.441860465116279,0.10475637205982,-0.388064791133845,-0.201570680628272,0.610526315789474,-0.761943986820428,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.028,-0.872,"9:8","149/150","C:K:I:T:S",1.58071061571228,0.0062231325401172,0.577790125858072,2.73578682807148,1.51864513964879,15.5428887748675,0.686493900966672,0.0089768751657447,2.04687481416212,1.29740576993775,18.1865471788576,0.0081667056971109,"lineage2","dr_mutations_pyrazinamide","ALA",0,"ERR2510684","ERR2510684","lineage2.2.1","it","Italy","pnca_p.thr47ala","A","E","THR","TA47","pnca_complex.pdb"
|
|
"T47A","L2","PZA","T","T47",47,"A",NA,"XDR","DM","hydrophobic","hydrophobic","neutral","non-polar","polar","non-polar",7.503,-2.172,-1.71,2.87617,-2.276,-0.77,58,75,-0.925,8,8,0,0,"strand",-0.933333333333333,10.3,0.0008624407072013,4.85840707964602,4.85840704522462,4.85767795624558,6.99654790120219,4,0,0,0,0,0,0,0,0,0,0,0,2,0,0,0,0,6,0,4,2,12,0,6,9,-0.550151975683891,-0.441860465116279,0.10475637205982,-0.388064791133845,-0.201570680628272,0.610526315789474,-0.761943986820428,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.028,-0.872,"9:8","149/150","C:K:I:T:S",1.58071061571228,0.0062231325401172,0.577790125858072,2.73578682807148,1.51864513964879,15.5428887748675,0.686493900966672,0.0089768751657447,2.04687481416212,1.29740576993775,18.1865471788576,0.0081667056971109,"lineage2","dr_mutations_pyrazinamide","ALA",0,"SRR671821,BGI_SH384","SRR671821","lineage2.2.1","cn","China","pnca_p.thr47ala","A","E","THR","TA47","pnca_complex.pdb"
|
|
"T47A","L2","PZA","T","T47",47,"A",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","neutral","non-polar","polar","non-polar",7.503,-2.172,-1.71,2.87617,-2.276,-0.77,58,75,-0.925,8,8,0,0,"strand",-0.933333333333333,10.3,0.0008624407072013,4.85840707964602,4.85840704522462,4.85767795624558,6.99654790120219,4,0,0,0,0,0,0,0,0,0,0,0,2,0,0,0,0,6,0,4,2,12,0,6,9,-0.550151975683891,-0.441860465116279,0.10475637205982,-0.388064791133845,-0.201570680628272,0.610526315789474,-0.761943986820428,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.028,-0.872,"9:8","149/150","C:K:I:T:S",1.58071061571228,0.0062231325401172,0.577790125858072,2.73578682807148,1.51864513964879,15.5428887748675,0.686493900966672,0.0089768751657447,2.04687481416212,1.29740576993775,18.1865471788576,0.0081667056971109,"lineage2","dr_mutations_pyrazinamide","ALA",0,"SRS797065","SRR1723568","lineage2.2.1","cn","China:Shandong","pnca_p.thr47ala","A","E","THR","TA47","pnca_complex.pdb"
|
|
"T47A","L2","PZA","T","T47",47,"A",1,"Pre-MDR","DM","hydrophobic","hydrophobic","neutral","non-polar","polar","non-polar",7.503,-2.172,-1.71,2.87617,-2.276,-0.77,58,75,-0.925,8,8,0,0,"strand",-0.933333333333333,10.3,0.0008624407072013,4.85840707964602,4.85840704522462,4.85767795624558,6.99654790120219,4,0,0,0,0,0,0,0,0,0,0,0,2,0,0,0,0,6,0,4,2,12,0,6,9,-0.550151975683891,-0.441860465116279,0.10475637205982,-0.388064791133845,-0.201570680628272,0.610526315789474,-0.761943986820428,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.028,-0.872,"9:8","149/150","C:K:I:T:S",1.58071061571228,0.0062231325401172,0.577790125858072,2.73578682807148,1.51864513964879,15.5428887748675,0.686493900966672,0.0089768751657447,2.04687481416212,1.29740576993775,18.1865471788576,0.0081667056971109,"lineage2","dr_mutations_pyrazinamide","ALA",0,"MDR_10443","SRR6824680","lineage2.2.1","cn","China: Pei County, Xuzhou City, Jiangsu Province","pnca_p.thr47ala","A","E","THR","TA47","pnca_complex.pdb"
|
|
"T47A","L2","PZA","T","T47",47,"A",0,"MDR","DM","hydrophobic","hydrophobic","neutral","non-polar","polar","non-polar",7.503,-2.172,-1.71,2.87617,-2.276,-0.77,58,75,-0.925,8,8,0,0,"strand",-0.933333333333333,10.3,0.0008624407072013,4.85840707964602,4.85840704522462,4.85767795624558,6.99654790120219,4,0,0,0,0,0,0,0,0,0,0,0,2,0,0,0,0,6,0,4,2,12,0,6,9,-0.550151975683891,-0.441860465116279,0.10475637205982,-0.388064791133845,-0.201570680628272,0.610526315789474,-0.761943986820428,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.028,-0.872,"9:8","149/150","C:K:I:T:S",1.58071061571228,0.0062231325401172,0.577790125858072,2.73578682807148,1.51864513964879,15.5428887748675,0.686493900966672,0.0089768751657447,2.04687481416212,1.29740576993775,18.1865471788576,0.0081667056971109,"lineage2","dr_mutations_pyrazinamide","ALA",0,"4730-03,ERS457325","ERR551411_ERR551412","lineage2.2.1","","","pnca_p.thr47ala","A","E","THR","TA47","pnca_complex.pdb"
|
|
"T47A","L2","PZA","T","T47",47,"A",1,"Pre-XDR","DM","hydrophobic","hydrophobic","neutral","non-polar","polar","non-polar",7.503,-2.172,-1.71,2.87617,-2.276,-0.77,58,75,-0.925,8,8,0,0,"strand",-0.933333333333333,10.3,0.0008624407072013,4.85840707964602,4.85840704522462,4.85767795624558,6.99654790120219,4,0,0,0,0,0,0,0,0,0,0,0,2,0,0,0,0,6,0,4,2,12,0,6,9,-0.550151975683891,-0.441860465116279,0.10475637205982,-0.388064791133845,-0.201570680628272,0.610526315789474,-0.761943986820428,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.028,-0.872,"9:8","149/150","C:K:I:T:S",1.58071061571228,0.0062231325401172,0.577790125858072,2.73578682807148,1.51864513964879,15.5428887748675,0.686493900966672,0.0089768751657447,2.04687481416212,1.29740576993775,18.1865471788576,0.0081667056971109,"lineage2","dr_mutations_pyrazinamide","ALA",0,"MDR_15228","SRR6824559","lineage2.2.1","cn","China: Changle County, Weifang City, Shandong Province","pnca_p.thr47ala","A","E","THR","TA47","pnca_complex.pdb"
|
|
"T47A","L2","PZA","T","T47",47,"A",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","neutral","non-polar","polar","non-polar",7.503,-2.172,-1.71,2.87617,-2.276,-0.77,58,75,-0.925,8,8,0,0,"strand",-0.933333333333333,10.3,0.0008624407072013,4.85840707964602,4.85840704522462,4.85767795624558,6.99654790120219,4,0,0,0,0,0,0,0,0,0,0,0,2,0,0,0,0,6,0,4,2,12,0,6,9,-0.550151975683891,-0.441860465116279,0.10475637205982,-0.388064791133845,-0.201570680628272,0.610526315789474,-0.761943986820428,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.028,-0.872,"9:8","149/150","C:K:I:T:S",1.58071061571228,0.0062231325401172,0.577790125858072,2.73578682807148,1.51864513964879,15.5428887748675,0.686493900966672,0.0089768751657447,2.04687481416212,1.29740576993775,18.1865471788576,0.0081667056971109,"lineage2","dr_mutations_pyrazinamide","ALA",0,"SAMN02414984","SRR1166878_SRR1162765_SRR1165490_SRR1165550","lineage2.2.1","se","Sweden","pnca_p.thr47ala","A","E","THR","TA47","pnca_complex.pdb"
|
|
"T47A","L2","PZA","T","T47",47,"A",1,"XDR","DM","hydrophobic","hydrophobic","neutral","non-polar","polar","non-polar",7.503,-2.172,-1.71,2.87617,-2.276,-0.77,58,75,-0.925,8,8,0,0,"strand",-0.933333333333333,10.3,0.0008624407072013,4.85840707964602,4.85840704522462,4.85767795624558,6.99654790120219,4,0,0,0,0,0,0,0,0,0,0,0,2,0,0,0,0,6,0,4,2,12,0,6,9,-0.550151975683891,-0.441860465116279,0.10475637205982,-0.388064791133845,-0.201570680628272,0.610526315789474,-0.761943986820428,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.028,-0.872,"9:8","149/150","C:K:I:T:S",1.58071061571228,0.0062231325401172,0.577790125858072,2.73578682807148,1.51864513964879,15.5428887748675,0.686493900966672,0.0089768751657447,2.04687481416212,1.29740576993775,18.1865471788576,0.0081667056971109,"lineage2","dr_mutations_pyrazinamide","ALA",0,"SAMN10961337","SRR8651576","lineage2.2.1","cn","China:Wenzhou","pnca_p.thr47ala","A","E","THR","TA47","pnca_complex.pdb"
|
|
"T47A","L2","PZA","T","T47",47,"A",0,"MDR","DM","hydrophobic","hydrophobic","neutral","non-polar","polar","non-polar",7.503,-2.172,-1.71,2.87617,-2.276,-0.77,58,75,-0.925,8,8,0,0,"strand",-0.933333333333333,10.3,0.0008624407072013,4.85840707964602,4.85840704522462,4.85767795624558,6.99654790120219,4,0,0,0,0,0,0,0,0,0,0,0,2,0,0,0,0,6,0,4,2,12,0,6,9,-0.550151975683891,-0.441860465116279,0.10475637205982,-0.388064791133845,-0.201570680628272,0.610526315789474,-0.761943986820428,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.028,-0.872,"9:8","149/150","C:K:I:T:S",1.58071061571228,0.0062231325401172,0.577790125858072,2.73578682807148,1.51864513964879,15.5428887748675,0.686493900966672,0.0089768751657447,2.04687481416212,1.29740576993775,18.1865471788576,0.0081667056971109,"lineage2","dr_mutations_pyrazinamide","ALA",0,"4724-03,ERR552658","ERR552658","lineage2.2.1","","","pnca_p.thr47ala","A","E","THR","TA47","pnca_complex.pdb"
|
|
"T47A","L2","PZA","T","T47",47,"A",NA,"Pre-MDR","DM","hydrophobic","hydrophobic","neutral","non-polar","polar","non-polar",7.503,-2.172,-1.71,2.87617,-2.276,-0.77,58,75,-0.925,8,8,0,0,"strand",-0.933333333333333,10.3,0.0008624407072013,4.85840707964602,4.85840704522462,4.85767795624558,6.99654790120219,4,0,0,0,0,0,0,0,0,0,0,0,2,0,0,0,0,6,0,4,2,12,0,6,9,-0.550151975683891,-0.441860465116279,0.10475637205982,-0.388064791133845,-0.201570680628272,0.610526315789474,-0.761943986820428,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.028,-0.872,"9:8","149/150","C:K:I:T:S",1.58071061571228,0.0062231325401172,0.577790125858072,2.73578682807148,1.51864513964879,15.5428887748675,0.686493900966672,0.0089768751657447,2.04687481416212,1.29740576993775,18.1865471788576,0.0081667056971109,"lineage2","dr_mutations_pyrazinamide","ALA",0,"SRS797110","SRR1723619","lineage2.2.1","cn","China:Shandong","pnca_p.thr47ala","A","E","THR","TA47","pnca_complex.pdb"
|
|
"T47A","L2","PZA","T","T47",47,"A",1,"Pre-MDR","DM","hydrophobic","hydrophobic","neutral","non-polar","polar","non-polar",7.503,-2.172,-1.71,2.87617,-2.276,-0.77,58,75,-0.925,8,8,0,0,"strand",-0.933333333333333,10.3,0.0008624407072013,4.85840707964602,4.85840704522462,4.85767795624558,6.99654790120219,4,0,0,0,0,0,0,0,0,0,0,0,2,0,0,0,0,6,0,4,2,12,0,6,9,-0.550151975683891,-0.441860465116279,0.10475637205982,-0.388064791133845,-0.201570680628272,0.610526315789474,-0.761943986820428,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.028,-0.872,"9:8","149/150","C:K:I:T:S",1.58071061571228,0.0062231325401172,0.577790125858072,2.73578682807148,1.51864513964879,15.5428887748675,0.686493900966672,0.0089768751657447,2.04687481416212,1.29740576993775,18.1865471788576,0.0081667056971109,"lineage2","dr_mutations_pyrazinamide","ALA",0,"MDR_15403","SRR6824379","lineage2.2.1","cn","China: Laiyang City, Yantai City, Shandong Province","pnca_p.thr47ala","A","E","THR","TA47","pnca_complex.pdb"
|
|
"T47A","L2","PZA","T","T47",47,"A",NA,"Pre-MDR","DM","hydrophobic","hydrophobic","neutral","non-polar","polar","non-polar",7.503,-2.172,-1.71,2.87617,-2.276,-0.77,58,75,-0.925,8,8,0,0,"strand",-0.933333333333333,10.3,0.0008624407072013,4.85840707964602,4.85840704522462,4.85767795624558,6.99654790120219,4,0,0,0,0,0,0,0,0,0,0,0,2,0,0,0,0,6,0,4,2,12,0,6,9,-0.550151975683891,-0.441860465116279,0.10475637205982,-0.388064791133845,-0.201570680628272,0.610526315789474,-0.761943986820428,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.028,-0.872,"9:8","149/150","C:K:I:T:S",1.58071061571228,0.0062231325401172,0.577790125858072,2.73578682807148,1.51864513964879,15.5428887748675,0.686493900966672,0.0089768751657447,2.04687481416212,1.29740576993775,18.1865471788576,0.0081667056971109,"lineage2","dr_mutations_pyrazinamide","ALA",0,"SRS797221","SRR1723744","lineage2.2.1","cn","China:Jiangsu","pnca_p.thr47ala","A","E","THR","TA47","pnca_complex.pdb"
|
|
"T47A","L4","PZA","T","T47",47,"A",0,"Pre-XDR","DM","hydrophobic","hydrophobic","neutral","non-polar","polar","non-polar",7.503,-2.172,-1.71,2.87617,-2.276,-0.77,58,75,-0.925,8,8,0,0,"strand",-0.933333333333333,10.3,0.0008624407072013,4.85840707964602,4.85840704522462,4.85767795624558,6.99654790120219,4,0,0,0,0,0,0,0,0,0,0,0,2,0,0,0,0,6,0,4,2,12,0,6,9,-0.550151975683891,-0.441860465116279,0.10475637205982,-0.388064791133845,-0.201570680628272,0.610526315789474,-0.761943986820428,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.028,-0.872,"9:8","149/150","C:K:I:T:S",1.58071061571228,0.0062231325401172,0.577790125858072,2.73578682807148,1.51864513964879,15.5428887748675,0.686493900966672,0.0089768751657447,2.04687481416212,1.29740576993775,18.1865471788576,0.0081667056971109,"lineage4","dr_mutations_pyrazinamide","ALA",0,"ERR2516598","ERR2516598","lineage4.1.1","pe","Peru","pnca_p.thr47ala","A","E","THR","TA47","pnca_complex.pdb"
|
|
"T47I","L4","PZA","T","T47",47,"I",0,"Pre-XDR","OM","hydrophobic","hydrophobic","neutral","non-polar","polar","non-polar",7.503,-2.112,-0.155,-1.0395,-1.52,-0.62,72,85,-0.925,8,8,0,0,"strand",-0.933333333333333,10.3,0.0003593502946672,1.21225820016821,1.21225918982515,1.212214074125,7.19297638498975e-25,-32,2,0,0,2,0,0,0,0,0,0,0,2,0,0,0,0,-2,0,-3,-1,2,0,0,4,-0.534954407294833,-0.0400516795865633,-0.199857725140352,-0.259164535379369,-0.162303664921466,0.757894736842105,-0.761943986820428,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.028,-0.872,"9:8","149/150","C:K:I:T:S",0.192485717774877,0.863268405978747,1.11770505415734,0.172215126932566,0.061955084955231,8.19905671742341,0.083595130527928,1,0,0.0246053772172713,12.260612593354,0.999999999999323,"lineage4","other_mutations_pyrazinamide","ILE",0,"SAMN10961346","SRR8651588","lineage4.4.2","cn","China:Wenzhou","pnca_p.thr47ile","A","E","THR","TA47","pnca_complex.pdb"
|
|
"T47I","L4","PZA","T","T47",47,"I",1,"Pre-MDR","OM","hydrophobic","hydrophobic","neutral","non-polar","polar","non-polar",7.503,-2.112,-0.155,-1.0395,-1.52,-0.62,72,85,-0.925,8,8,0,0,"strand",-0.933333333333333,10.3,0.0003593502946672,1.21225820016821,1.21225918982515,1.212214074125,7.19297638498975e-25,-32,2,0,0,2,0,0,0,0,0,0,0,2,0,0,0,0,-2,0,-3,-1,2,0,0,4,-0.534954407294833,-0.0400516795865633,-0.199857725140352,-0.259164535379369,-0.162303664921466,0.757894736842105,-0.761943986820428,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.028,-0.872,"9:8","149/150","C:K:I:T:S",0.192485717774877,0.863268405978747,1.11770505415734,0.172215126932566,0.061955084955231,8.19905671742341,0.083595130527928,1,0,0.0246053772172713,12.260612593354,0.999999999999323,"lineage4","other_mutations_pyrazinamide","ILE",0,"ERR2510489","ERR2510489","lineage4.6","pk","Pakistan","pnca_p.thr47ile","A","E","THR","TA47","pnca_complex.pdb"
|
|
"T47I","L4","PZA","T","T47",47,"I",0,"Pre-XDR","OM","hydrophobic","hydrophobic","neutral","non-polar","polar","non-polar",7.503,-2.112,-0.155,-1.0395,-1.52,-0.62,72,85,-0.925,8,8,0,0,"strand",-0.933333333333333,10.3,0.0003593502946672,1.21225820016821,1.21225918982515,1.212214074125,7.19297638498975e-25,-32,2,0,0,2,0,0,0,0,0,0,0,2,0,0,0,0,-2,0,-3,-1,2,0,0,4,-0.534954407294833,-0.0400516795865633,-0.199857725140352,-0.259164535379369,-0.162303664921466,0.757894736842105,-0.761943986820428,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.028,-0.872,"9:8","149/150","C:K:I:T:S",0.192485717774877,0.863268405978747,1.11770505415734,0.172215126932566,0.061955084955231,8.19905671742341,0.083595130527928,1,0,0.0246053772172713,12.260612593354,0.999999999999323,"lineage4","other_mutations_pyrazinamide","ILE",0,"ERR2510592","ERR2510592","lineage4.6.2.2","pk","Pakistan","pnca_p.thr47ile","A","E","THR","TA47","pnca_complex.pdb"
|
|
"T47I","L3","PZA","T","T47",47,"I",0,"MDR","OM","hydrophobic","hydrophobic","neutral","non-polar","polar","non-polar",7.503,-2.112,-0.155,-1.0395,-1.52,-0.62,72,85,-0.925,8,8,0,0,"strand",-0.933333333333333,10.3,0.0003593502946672,1.21225820016821,1.21225918982515,1.212214074125,7.19297638498975e-25,-32,2,0,0,2,0,0,0,0,0,0,0,2,0,0,0,0,-2,0,-3,-1,2,0,0,4,-0.534954407294833,-0.0400516795865633,-0.199857725140352,-0.259164535379369,-0.162303664921466,0.757894736842105,-0.761943986820428,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.028,-0.872,"9:8","149/150","C:K:I:T:S",0.192485717774877,0.863268405978747,1.11770505415734,0.172215126932566,0.061955084955231,8.19905671742341,0.083595130527928,1,0,0.0246053772172713,12.260612593354,0.999999999999323,"lineage3","other_mutations_pyrazinamide","ILE",0,"SRR2100324,SAMN03647497","SRR2100324","lineage3.1","","","pnca_p.thr47ile","A","E","THR","TA47","pnca_complex.pdb"
|
|
"T47I","L4","PZA","T","T47",47,"I",0,"MDR","OM","hydrophobic","hydrophobic","neutral","non-polar","polar","non-polar",7.503,-2.112,-0.155,-1.0395,-1.52,-0.62,72,85,-0.925,8,8,0,0,"strand",-0.933333333333333,10.3,0.0003593502946672,1.21225820016821,1.21225918982515,1.212214074125,7.19297638498975e-25,-32,2,0,0,2,0,0,0,0,0,0,0,2,0,0,0,0,-2,0,-3,-1,2,0,0,4,-0.534954407294833,-0.0400516795865633,-0.199857725140352,-0.259164535379369,-0.162303664921466,0.757894736842105,-0.761943986820428,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.028,-0.872,"9:8","149/150","C:K:I:T:S",0.192485717774877,0.863268405978747,1.11770505415734,0.172215126932566,0.061955084955231,8.19905671742341,0.083595130527928,1,0,0.0246053772172713,12.260612593354,0.999999999999323,"lineage4","other_mutations_pyrazinamide","ILE",0,"ERR2515384","ERR2515384","lineage4.8","za","South Africa","pnca_p.thr47ile","A","E","THR","TA47","pnca_complex.pdb"
|
|
"T47I","L3","PZA","T","T47",47,"I",NA,"MDR","OM","hydrophobic","hydrophobic","neutral","non-polar","polar","non-polar",7.503,-2.112,-0.155,-1.0395,-1.52,-0.62,72,85,-0.925,8,8,0,0,"strand",-0.933333333333333,10.3,0.0003593502946672,1.21225820016821,1.21225918982515,1.212214074125,7.19297638498975e-25,-32,2,0,0,2,0,0,0,0,0,0,0,2,0,0,0,0,-2,0,-3,-1,2,0,0,4,-0.534954407294833,-0.0400516795865633,-0.199857725140352,-0.259164535379369,-0.162303664921466,0.757894736842105,-0.761943986820428,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.028,-0.872,"9:8","149/150","C:K:I:T:S",0.192485717774877,0.863268405978747,1.11770505415734,0.172215126932566,0.061955084955231,8.19905671742341,0.083595130527928,1,0,0.0246053772172713,12.260612593354,0.999999999999323,"lineage3","other_mutations_pyrazinamide","ILE",0,"ERR234111","ERR234111","lineage3.1","np","Nepal","pnca_p.thr47ile","A","E","THR","TA47","pnca_complex.pdb"
|
|
"T47N","L3","PZA","T","T47",47,"N",0,"Pre-XDR","OM","hydrophobic","hydrophilic","neutral","neutral","polar","polar",7.503,-0.208,-1.831,0.956982,-5.182,-1.29,77,85,-0.925,8,8,0,0,"strand",-0.933333333333333,10.3,7.18700589334483e-05,2.42412778478352,0.0001249735077034,0,1.03410070803344e-29,-26,2,0,0,2,0,0,0,0,-4,0,-2,2,0,0,0,0,0,0,1,-1,-4,0,-6,2,-0.0526849037487335,-0.47312661498708,0.0348553675361854,-0.883546462063086,-0.337696335078534,0.810526315789474,-0.761943986820428,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.028,-0.872,"9:8","149/150","C:K:I:T:S",-8.98740878149641,0.940032862253634,119.468044435492,-0.0752285585987742,NA,4692673.51081218,0.384555509373631,1,0,0,188.544222231268,0.999999999999997,"lineage3","other_mutations_pyrazinamide","ASN",0,"ERR2510633","ERR2510633","lineage3","pk","Pakistan","pnca_p.thr47asn","A","E","THR","TA47","pnca_complex.pdb"
|
|
"T47P","L3","PZA","T","T47",47,"P",0,"MDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",7.503,-1.892,-1.493,1.93613,-5.056,-1.52,87,91,-0.925,8,8,0,0,"strand",-0.933333333333333,10.3,0.0001437401178668,1.2119588062211,4.5970013133425e-05,0,1.01056822389159e-25,4,2,0,0,2,0,0,0,0,2,2,0,2,0,0,0,0,4,0,2,2,8,0,6,0,-0.479229989868288,-0.38578811369509,0.0705180690418782,-0.862063086104007,-0.397905759162304,0.91578947368421,-0.761943986820428,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.028,-0.872,"9:8","149/150","C:K:I:T:S",-9.98752126245062,0.942832958100734,139.277183325398,-0.071709672926946,NA,144471.70631486,0.0834878586628579,1,0,0,25.8386585962163,0.999999999999746,"lineage3","dr_mutations_pyrazinamide","PRO",0,"ERR2510424","ERR2510424","lineage3","pk","Pakistan","pnca_p.thr47pro","A","E","THR","TA47","pnca_complex.pdb"
|
|
"T47P","L4","PZA","T","T47",47,"P",0,"Pre-XDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",7.503,-1.892,-1.493,1.93613,-5.056,-1.52,87,91,-0.925,8,8,0,0,"strand",-0.933333333333333,10.3,0.0001437401178668,1.2119588062211,4.5970013133425e-05,0,1.01056822389159e-25,4,2,0,0,2,0,0,0,0,2,2,0,2,0,0,0,0,4,0,2,2,8,0,6,0,-0.479229989868288,-0.38578811369509,0.0705180690418782,-0.862063086104007,-0.397905759162304,0.91578947368421,-0.761943986820428,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.028,-0.872,"9:8","149/150","C:K:I:T:S",-9.98752126245062,0.942832958100734,139.277183325398,-0.071709672926946,NA,144471.70631486,0.0834878586628579,1,0,0,25.8386585962163,0.999999999999746,"lineage4","dr_mutations_pyrazinamide","PRO",0,"SAMN10961394","SRR8651637","lineage4.4.2","cn","China:Wenzhou","pnca_p.thr47pro","A","E","THR","TA47","pnca_complex.pdb"
|
|
"T47P","L4","PZA","T","T47",47,"P",NA,"MDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",7.503,-1.892,-1.493,1.93613,-5.056,-1.52,87,91,-0.925,8,8,0,0,"strand",-0.933333333333333,10.3,0.0001437401178668,1.2119588062211,4.5970013133425e-05,0,1.01056822389159e-25,4,2,0,0,2,0,0,0,0,2,2,0,2,0,0,0,0,4,0,2,2,8,0,6,0,-0.479229989868288,-0.38578811369509,0.0705180690418782,-0.862063086104007,-0.397905759162304,0.91578947368421,-0.761943986820428,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.028,-0.872,"9:8","149/150","C:K:I:T:S",-9.98752126245062,0.942832958100734,139.277183325398,-0.071709672926946,NA,144471.70631486,0.0834878586628579,1,0,0,25.8386585962163,0.999999999999746,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR1035305","ERR1035305","lineage4.1.2.1","br","Brazil","pnca_p.thr47pro","A","E","THR","TA47","pnca_complex.pdb"
|
|
"T47P","L2","PZA","T","T47",47,"P",NA,"MDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",7.503,-1.892,-1.493,1.93613,-5.056,-1.52,87,91,-0.925,8,8,0,0,"strand",-0.933333333333333,10.3,0.0001437401178668,1.2119588062211,4.5970013133425e-05,0,1.01056822389159e-25,4,2,0,0,2,0,0,0,0,2,2,0,2,0,0,0,0,4,0,2,2,8,0,6,0,-0.479229989868288,-0.38578811369509,0.0705180690418782,-0.862063086104007,-0.397905759162304,0.91578947368421,-0.761943986820428,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.028,-0.872,"9:8","149/150","C:K:I:T:S",-9.98752126245062,0.942832958100734,139.277183325398,-0.071709672926946,NA,144471.70631486,0.0834878586628579,1,0,0,25.8386585962163,0.999999999999746,"lineage2","dr_mutations_pyrazinamide","PRO",0,"ERR752149","ERR752149","lineage2.2.1.1","th","Thailand","pnca_p.thr47pro","A","E","THR","TA47","pnca_complex.pdb"
|
|
"T47P","L2","PZA","T","T47",47,"P",NA,"XDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",7.503,-1.892,-1.493,1.93613,-5.056,-1.52,87,91,-0.925,8,8,0,0,"strand",-0.933333333333333,10.3,0.0001437401178668,1.2119588062211,4.5970013133425e-05,0,1.01056822389159e-25,4,2,0,0,2,0,0,0,0,2,2,0,2,0,0,0,0,4,0,2,2,8,0,6,0,-0.479229989868288,-0.38578811369509,0.0705180690418782,-0.862063086104007,-0.397905759162304,0.91578947368421,-0.761943986820428,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.028,-0.872,"9:8","149/150","C:K:I:T:S",-9.98752126245062,0.942832958100734,139.277183325398,-0.071709672926946,NA,144471.70631486,0.0834878586628579,1,0,0,25.8386585962163,0.999999999999746,"lineage2","dr_mutations_pyrazinamide","PRO",0,"SRR5709911,SAMN07236413","SRR5709911","lineage2.2.1.1","th","Thailand","pnca_p.thr47pro","A","E","THR","TA47","pnca_complex.pdb"
|
|
"T47P","L4","PZA","T","T47",47,"P",NA,"MDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",7.503,-1.892,-1.493,1.93613,-5.056,-1.52,87,91,-0.925,8,8,0,0,"strand",-0.933333333333333,10.3,0.0001437401178668,1.2119588062211,4.5970013133425e-05,0,1.01056822389159e-25,4,2,0,0,2,0,0,0,0,2,2,0,2,0,0,0,0,4,0,2,2,8,0,6,0,-0.479229989868288,-0.38578811369509,0.0705180690418782,-0.862063086104007,-0.397905759162304,0.91578947368421,-0.761943986820428,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.028,-0.872,"9:8","149/150","C:K:I:T:S",-9.98752126245062,0.942832958100734,139.277183325398,-0.071709672926946,NA,144471.70631486,0.0834878586628579,1,0,0,25.8386585962163,0.999999999999746,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR1035294","ERR1035294","lineage4.1.2.1","br","Brazil","pnca_p.thr47pro","A","E","THR","TA47","pnca_complex.pdb"
|
|
"K48E","L2","PZA","K","K48",48,"E",NA,"XDR","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",7.546,-1.91,-1.833,2.3862,-1.921,-1.95,53,75,-0.823,8,8,19,0.0805084745762711,"strand",-2.7,6.78,0.000646830530401,6.07150379106992,6.07150374077153,6.07036843596735,6.87801392972404,28,-28,0,0,-28,0,0,0,0,2,0,2,0,0,0,0,0,1,0,0,1,0,0,0,0,-0.483789260385005,-0.473643410852713,0.0869105981249863,-0.327536231884058,-0.510471204188482,0.557894736842105,-0.677924217462932,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.914,-0.779,"8:8","149/150","I:K:R:L:Q:A",1.80360630763137,0.00720618942243,0.671193623356544,2.68716245933892,1.60530087074952,24.5460966015952,0.783296270528047,0.0099794518593429,2.00089331252028,1.30550120941319,30.6177596174465,0.0087262477054536,"lineage2","dr_mutations_pyrazinamide","GLU",0,"SAMN02360604","SRR1049046_SRR1049047_SRR1013650_SRR1013651","lineage2.2.2","kr","South Korea","pnca_p.lys48glu","A","E","LYS","KA48","pnca_complex.pdb"
|
|
"K48E","L2","PZA","K","K48",48,"E",NA,"MDR","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",7.546,-1.91,-1.833,2.3862,-1.921,-1.95,53,75,-0.823,8,8,19,0.0805084745762711,"strand",-2.7,6.78,0.000646830530401,6.07150379106992,6.07150374077153,6.07036843596735,6.87801392972404,28,-28,0,0,-28,0,0,0,0,2,0,2,0,0,0,0,0,1,0,0,1,0,0,0,0,-0.483789260385005,-0.473643410852713,0.0869105981249863,-0.327536231884058,-0.510471204188482,0.557894736842105,-0.677924217462932,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.914,-0.779,"8:8","149/150","I:K:R:L:Q:A",1.80360630763137,0.00720618942243,0.671193623356544,2.68716245933892,1.60530087074952,24.5460966015952,0.783296270528047,0.0099794518593429,2.00089331252028,1.30550120941319,30.6177596174465,0.0087262477054536,"lineage2","dr_mutations_pyrazinamide","GLU",0,"SRS797156","SRR1723669_SRR1723668","lineage2.2.1","cn","China:Anhui","pnca_p.lys48glu","A","E","LYS","KA48","pnca_complex.pdb"
|
|
"K48E","L2","PZA","K","K48",48,"E",1,"XDR","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",7.546,-1.91,-1.833,2.3862,-1.921,-1.95,53,75,-0.823,8,8,19,0.0805084745762711,"strand",-2.7,6.78,0.000646830530401,6.07150379106992,6.07150374077153,6.07036843596735,6.87801392972404,28,-28,0,0,-28,0,0,0,0,2,0,2,0,0,0,0,0,1,0,0,1,0,0,0,0,-0.483789260385005,-0.473643410852713,0.0869105981249863,-0.327536231884058,-0.510471204188482,0.557894736842105,-0.677924217462932,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.914,-0.779,"8:8","149/150","I:K:R:L:Q:A",1.80360630763137,0.00720618942243,0.671193623356544,2.68716245933892,1.60530087074952,24.5460966015952,0.783296270528047,0.0099794518593429,2.00089331252028,1.30550120941319,30.6177596174465,0.0087262477054536,"lineage2","dr_mutations_pyrazinamide","GLU",0,"ERR137231,1446Y-sc-2012-02-21T11:36:41Z-1364723","ERR137231","lineage2.2.1","ru","Russia,Samara","pnca_p.lys48glu","A","E","LYS","KA48","pnca_complex.pdb"
|
|
"K48E","L2","PZA","K","K48",48,"E",NA,"MDR","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",7.546,-1.91,-1.833,2.3862,-1.921,-1.95,53,75,-0.823,8,8,19,0.0805084745762711,"strand",-2.7,6.78,0.000646830530401,6.07150379106992,6.07150374077153,6.07036843596735,6.87801392972404,28,-28,0,0,-28,0,0,0,0,2,0,2,0,0,0,0,0,1,0,0,1,0,0,0,0,-0.483789260385005,-0.473643410852713,0.0869105981249863,-0.327536231884058,-0.510471204188482,0.557894736842105,-0.677924217462932,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.914,-0.779,"8:8","149/150","I:K:R:L:Q:A",1.80360630763137,0.00720618942243,0.671193623356544,2.68716245933892,1.60530087074952,24.5460966015952,0.783296270528047,0.0099794518593429,2.00089331252028,1.30550120941319,30.6177596174465,0.0087262477054536,"lineage2","dr_mutations_pyrazinamide","GLU",0,"SRR5067439","SRR5067439","lineage2.2.1","vn","Vietnam","pnca_p.lys48glu","A","E","LYS","KA48","pnca_complex.pdb"
|
|
"K48E","L2","PZA","K","K48",48,"E",1,"MDR","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",7.546,-1.91,-1.833,2.3862,-1.921,-1.95,53,75,-0.823,8,8,19,0.0805084745762711,"strand",-2.7,6.78,0.000646830530401,6.07150379106992,6.07150374077153,6.07036843596735,6.87801392972404,28,-28,0,0,-28,0,0,0,0,2,0,2,0,0,0,0,0,1,0,0,1,0,0,0,0,-0.483789260385005,-0.473643410852713,0.0869105981249863,-0.327536231884058,-0.510471204188482,0.557894736842105,-0.677924217462932,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.914,-0.779,"8:8","149/150","I:K:R:L:Q:A",1.80360630763137,0.00720618942243,0.671193623356544,2.68716245933892,1.60530087074952,24.5460966015952,0.783296270528047,0.0099794518593429,2.00089331252028,1.30550120941319,30.6177596174465,0.0087262477054536,"lineage2","dr_mutations_pyrazinamide","GLU",0,"MDR_12177","SRR6824449","lineage2.2.1","cn","China: Jixi County, Xuancheng City, Anhui Province","pnca_p.lys48glu","A","E","LYS","KA48","pnca_complex.pdb"
|
|
"K48E","L2","PZA","K","K48",48,"E",0,"MDR","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",7.546,-1.91,-1.833,2.3862,-1.921,-1.95,53,75,-0.823,8,8,19,0.0805084745762711,"strand",-2.7,6.78,0.000646830530401,6.07150379106992,6.07150374077153,6.07036843596735,6.87801392972404,28,-28,0,0,-28,0,0,0,0,2,0,2,0,0,0,0,0,1,0,0,1,0,0,0,0,-0.483789260385005,-0.473643410852713,0.0869105981249863,-0.327536231884058,-0.510471204188482,0.557894736842105,-0.677924217462932,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.914,-0.779,"8:8","149/150","I:K:R:L:Q:A",1.80360630763137,0.00720618942243,0.671193623356544,2.68716245933892,1.60530087074952,24.5460966015952,0.783296270528047,0.0099794518593429,2.00089331252028,1.30550120941319,30.6177596174465,0.0087262477054536,"lineage2","dr_mutations_pyrazinamide","GLU",0,"ERS456887,SAMEA2533485","ERR550808_ERR550809","lineage2.2.1","uz","Nukus","pnca_p.lys48glu","A","E","LYS","KA48","pnca_complex.pdb"
|
|
"K48E","L2","PZA","K","K48",48,"E",1,"MDR","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",7.546,-1.91,-1.833,2.3862,-1.921,-1.95,53,75,-0.823,8,8,19,0.0805084745762711,"strand",-2.7,6.78,0.000646830530401,6.07150379106992,6.07150374077153,6.07036843596735,6.87801392972404,28,-28,0,0,-28,0,0,0,0,2,0,2,0,0,0,0,0,1,0,0,1,0,0,0,0,-0.483789260385005,-0.473643410852713,0.0869105981249863,-0.327536231884058,-0.510471204188482,0.557894736842105,-0.677924217462932,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.914,-0.779,"8:8","149/150","I:K:R:L:Q:A",1.80360630763137,0.00720618942243,0.671193623356544,2.68716245933892,1.60530087074952,24.5460966015952,0.783296270528047,0.0099794518593429,2.00089331252028,1.30550120941319,30.6177596174465,0.0087262477054536,"lineage2","dr_mutations_pyrazinamide","GLU",0,"MDR_16510","SRR6824571","lineage2.2.1","cn","China: Nanyang City, Henan Province","pnca_p.lys48glu","A","E","LYS","KA48","pnca_complex.pdb"
|
|
"K48E","L2","PZA","K","K48",48,"E",0,"Pre-XDR","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",7.546,-1.91,-1.833,2.3862,-1.921,-1.95,53,75,-0.823,8,8,19,0.0805084745762711,"strand",-2.7,6.78,0.000646830530401,6.07150379106992,6.07150374077153,6.07036843596735,6.87801392972404,28,-28,0,0,-28,0,0,0,0,2,0,2,0,0,0,0,0,1,0,0,1,0,0,0,0,-0.483789260385005,-0.473643410852713,0.0869105981249863,-0.327536231884058,-0.510471204188482,0.557894736842105,-0.677924217462932,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.914,-0.779,"8:8","149/150","I:K:R:L:Q:A",1.80360630763137,0.00720618942243,0.671193623356544,2.68716245933892,1.60530087074952,24.5460966015952,0.783296270528047,0.0099794518593429,2.00089331252028,1.30550120941319,30.6177596174465,0.0087262477054536,"lineage2","dr_mutations_pyrazinamide","GLU",0,"ERS458182","ERR552632_ERR552631","lineage2.2.1","uz","Nukus","pnca_p.lys48glu","A","E","LYS","KA48","pnca_complex.pdb"
|
|
"K48E","L2","PZA","K","K48",48,"E",NA,"MDR","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",7.546,-1.91,-1.833,2.3862,-1.921,-1.95,53,75,-0.823,8,8,19,0.0805084745762711,"strand",-2.7,6.78,0.000646830530401,6.07150379106992,6.07150374077153,6.07036843596735,6.87801392972404,28,-28,0,0,-28,0,0,0,0,2,0,2,0,0,0,0,0,1,0,0,1,0,0,0,0,-0.483789260385005,-0.473643410852713,0.0869105981249863,-0.327536231884058,-0.510471204188482,0.557894736842105,-0.677924217462932,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.914,-0.779,"8:8","149/150","I:K:R:L:Q:A",1.80360630763137,0.00720618942243,0.671193623356544,2.68716245933892,1.60530087074952,24.5460966015952,0.783296270528047,0.0099794518593429,2.00089331252028,1.30550120941319,30.6177596174465,0.0087262477054536,"lineage2","dr_mutations_pyrazinamide","GLU",0,"SRS797302","SRR1723832","lineage2.2.1","cn","China:Henan","pnca_p.lys48glu","A","E","LYS","KA48","pnca_complex.pdb"
|
|
"K48E","L2","PZA","K","K48",48,"E",1,"Pre-XDR","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",7.546,-1.91,-1.833,2.3862,-1.921,-1.95,53,75,-0.823,8,8,19,0.0805084745762711,"strand",-2.7,6.78,0.000646830530401,6.07150379106992,6.07150374077153,6.07036843596735,6.87801392972404,28,-28,0,0,-28,0,0,0,0,2,0,2,0,0,0,0,0,1,0,0,1,0,0,0,0,-0.483789260385005,-0.473643410852713,0.0869105981249863,-0.327536231884058,-0.510471204188482,0.557894736842105,-0.677924217462932,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.914,-0.779,"8:8","149/150","I:K:R:L:Q:A",1.80360630763137,0.00720618942243,0.671193623356544,2.68716245933892,1.60530087074952,24.5460966015952,0.783296270528047,0.0099794518593429,2.00089331252028,1.30550120941319,30.6177596174465,0.0087262477054536,"lineage2","dr_mutations_pyrazinamide","GLU",0,"ERS457334","ERR551422_ERR551424_ERR551423","lineage2.2.1","uz","Nukus","pnca_p.lys48glu","A","E","LYS","KA48","pnca_complex.pdb"
|
|
"K48E","L2","PZA","K","K48",48,"E",1,"XDR","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",7.546,-1.91,-1.833,2.3862,-1.921,-1.95,53,75,-0.823,8,8,19,0.0805084745762711,"strand",-2.7,6.78,0.000646830530401,6.07150379106992,6.07150374077153,6.07036843596735,6.87801392972404,28,-28,0,0,-28,0,0,0,0,2,0,2,0,0,0,0,0,1,0,0,1,0,0,0,0,-0.483789260385005,-0.473643410852713,0.0869105981249863,-0.327536231884058,-0.510471204188482,0.557894736842105,-0.677924217462932,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.914,-0.779,"8:8","149/150","I:K:R:L:Q:A",1.80360630763137,0.00720618942243,0.671193623356544,2.68716245933892,1.60530087074952,24.5460966015952,0.783296270528047,0.0099794518593429,2.00089331252028,1.30550120941319,30.6177596174465,0.0087262477054536,"lineage2","dr_mutations_pyrazinamide","GLU",0,"ERS456791","ERR550683_ERR550682_ERR550681","lineage2.2.1","uz","Nukus","pnca_p.lys48glu","A","E","LYS","KA48","pnca_complex.pdb"
|
|
"K48E","L4","PZA","K","K48",48,"E",0,"MDR","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",7.546,-1.91,-1.833,2.3862,-1.921,-1.95,53,75,-0.823,8,8,19,0.0805084745762711,"strand",-2.7,6.78,0.000646830530401,6.07150379106992,6.07150374077153,6.07036843596735,6.87801392972404,28,-28,0,0,-28,0,0,0,0,2,0,2,0,0,0,0,0,1,0,0,1,0,0,0,0,-0.483789260385005,-0.473643410852713,0.0869105981249863,-0.327536231884058,-0.510471204188482,0.557894736842105,-0.677924217462932,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.914,-0.779,"8:8","149/150","I:K:R:L:Q:A",1.80360630763137,0.00720618942243,0.671193623356544,2.68716245933892,1.60530087074952,24.5460966015952,0.783296270528047,0.0099794518593429,2.00089331252028,1.30550120941319,30.6177596174465,0.0087262477054536,"lineage4","dr_mutations_pyrazinamide","GLU",0,"MDR_23344","SRR6824479","lineage4.5","cn","China: Fucheng District, Mianyang City, Sichuan Province","pnca_p.lys48glu","A","E","LYS","KA48","pnca_complex.pdb"
|
|
"K48E","L2","PZA","K","K48",48,"E",0,"Pre-XDR","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",7.546,-1.91,-1.833,2.3862,-1.921,-1.95,53,75,-0.823,8,8,19,0.0805084745762711,"strand",-2.7,6.78,0.000646830530401,6.07150379106992,6.07150374077153,6.07036843596735,6.87801392972404,28,-28,0,0,-28,0,0,0,0,2,0,2,0,0,0,0,0,1,0,0,1,0,0,0,0,-0.483789260385005,-0.473643410852713,0.0869105981249863,-0.327536231884058,-0.510471204188482,0.557894736842105,-0.677924217462932,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.914,-0.779,"8:8","149/150","I:K:R:L:Q:A",1.80360630763137,0.00720618942243,0.671193623356544,2.68716245933892,1.60530087074952,24.5460966015952,0.783296270528047,0.0099794518593429,2.00089331252028,1.30550120941319,30.6177596174465,0.0087262477054536,"lineage2","dr_mutations_pyrazinamide","GLU",0,"0041W-sc-2011-10-12T14:59:38Z-1289180,ERR108515","ERR108515","lineage2.2.1","ru","Russia,Samara","pnca_p.lys48glu","A","E","LYS","KA48","pnca_complex.pdb"
|
|
"K48N","L3","PZA","K","K48",48,"N",0,"Pre-XDR","OM","hydrophobic","hydrophilic","basic","neutral","pos","polar",7.546,-1.168,-2.178,2.2078,-2.869,-1.86,67,80,-0.823,8,8,19,0.0805084745762711,"strand",-2.7,6.78,0.0001437401178668,1.2119588062211,4.59700131334259e-05,0,1.01056822389159e-25,46,24,0,0,24,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-2,1,2,0,0,-2,-0.295845997973658,-0.562790697674419,0.0804128817954676,-0.489173060528559,-0.486910994764398,0.705263157894737,-0.677924217462932,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.914,-0.779,"8:8","149/150","I:K:R:L:Q:A",-9.9875212624506,0.942832958100734,139.277183325398,-0.0717096729269463,NA,144471.706314829,0.0834878586628579,1,0,0,25.8386585962163,0.999999999999746,"lineage3","other_mutations_pyrazinamide","ASN",0,"ERR2510272","ERR2510272","lineage3","pk","Pakistan","pnca_p.lys48asn","A","E","LYS","KA48","pnca_complex.pdb"
|
|
"K48N","L4","PZA","K","K48",48,"N",0,"MDR","OM","hydrophobic","hydrophilic","basic","neutral","pos","polar",7.546,-1.168,-2.178,2.2078,-2.869,-1.86,67,80,-0.823,8,8,19,0.0805084745762711,"strand",-2.7,6.78,0.0001437401178668,1.2119588062211,4.59700131334259e-05,0,1.01056822389159e-25,46,24,0,0,24,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-2,1,2,0,0,-2,-0.295845997973658,-0.562790697674419,0.0804128817954676,-0.489173060528559,-0.486910994764398,0.705263157894737,-0.677924217462932,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.914,-0.779,"8:8","149/150","I:K:R:L:Q:A",-9.9875212624506,0.942832958100734,139.277183325398,-0.0717096729269463,NA,144471.706314829,0.0834878586628579,1,0,0,25.8386585962163,0.999999999999746,"lineage4","other_mutations_pyrazinamide","ASN",0,"ERR2516615","ERR2516615","lineage4.3.3","pe","Peru","pnca_p.lys48asn","A","E","LYS","KA48","pnca_complex.pdb"
|
|
"K48Q","L4","PZA","K","K48",48,"Q",NA,"Pre-MDR","OM","hydrophobic","hydrophilic","basic","neutral","pos","polar",7.546,-1.653,-1.537,1.38977,-0.028,-1.89,-61,82,-0.823,8,8,19,0.0805084745762711,"strand",-2.7,6.78,NA,NA,NA,NA,NA,28,24,0,0,24,0,0,0,0,0,0,2,-2,0,0,0,0,2,0,1,1,2,0,2,-4,-0.418693009118541,-0.397157622739018,0.0506184485609598,-0.00477408354646206,-0.494764397905759,-0.655913978494624,-0.677924217462932,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","neutral",-0.914,-0.779,"8:8","149/150","I:K:R:L:Q:A",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage4","other_mutations_pyrazinamide","GLN",0,"ERR502532","ERR502532","lineage4.3","gh","Ghana","pnca_p.lys48gln","A","E","LYS","KA48","pnca_complex.pdb"
|
|
"K48Q","L1","PZA","K","K48",48,"Q",NA,"Pre-MDR","OM","hydrophobic","hydrophilic","basic","neutral","pos","polar",7.546,-1.653,-1.537,1.38977,-0.028,-1.89,-61,82,-0.823,8,8,19,0.0805084745762711,"strand",-2.7,6.78,NA,NA,NA,NA,NA,28,24,0,0,24,0,0,0,0,0,0,2,-2,0,0,0,0,2,0,1,1,2,0,2,-4,-0.418693009118541,-0.397157622739018,0.0506184485609598,-0.00477408354646206,-0.494764397905759,-0.655913978494624,-0.677924217462932,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","neutral",-0.914,-0.779,"8:8","149/150","I:K:R:L:Q:A",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage1","other_mutations_pyrazinamide","GLN",0,"ERR702404","ERR702404","lineage1","gh","Ghana","pnca_p.lys48gln","A","E","LYS","KA48","pnca_complex.pdb"
|
|
"K48Q","L4","PZA","K","K48",48,"Q",NA,"Pre-MDR","OM","hydrophobic","hydrophilic","basic","neutral","pos","polar",7.546,-1.653,-1.537,1.38977,-0.028,-1.89,-61,82,-0.823,8,8,19,0.0805084745762711,"strand",-2.7,6.78,NA,NA,NA,NA,NA,28,24,0,0,24,0,0,0,0,0,0,2,-2,0,0,0,0,2,0,1,1,2,0,2,-4,-0.418693009118541,-0.397157622739018,0.0506184485609598,-0.00477408354646206,-0.494764397905759,-0.655913978494624,-0.677924217462932,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","neutral",-0.914,-0.779,"8:8","149/150","I:K:R:L:Q:A",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage4","other_mutations_pyrazinamide","GLN",0,"SRR7496517","SRR7496517","lineage4.3","us","Hawaii","pnca_p.lys48gln","A","E","LYS","KA48","pnca_complex.pdb"
|
|
"K48Q","L4","PZA","K","K48",48,"Q",NA,"Pre-MDR","OM","hydrophobic","hydrophilic","basic","neutral","pos","polar",7.546,-1.653,-1.537,1.38977,-0.028,-1.89,-61,82,-0.823,8,8,19,0.0805084745762711,"strand",-2.7,6.78,NA,NA,NA,NA,NA,28,24,0,0,24,0,0,0,0,0,0,2,-2,0,0,0,0,2,0,1,1,2,0,2,-4,-0.418693009118541,-0.397157622739018,0.0506184485609598,-0.00477408354646206,-0.494764397905759,-0.655913978494624,-0.677924217462932,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","neutral",-0.914,-0.779,"8:8","149/150","I:K:R:L:Q:A",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage4","other_mutations_pyrazinamide","GLN",0,"SRR7496509","SRR7496509","lineage4.3","us","Hawaii","pnca_p.lys48gln","A","E","LYS","KA48","pnca_complex.pdb"
|
|
"K48Q","L4;L7","PZA","K","K48",48,"Q",NA,"Pre-MDR","OM","hydrophobic","hydrophilic","basic","neutral","pos","polar",7.546,-1.653,-1.537,1.38977,-0.028,-1.89,-61,82,-0.823,8,8,19,0.0805084745762711,"strand",-2.7,6.78,NA,NA,NA,NA,NA,28,24,0,0,24,0,0,0,0,0,0,2,-2,0,0,0,0,2,0,1,1,2,0,2,-4,-0.418693009118541,-0.397157622739018,0.0506184485609598,-0.00477408354646206,-0.494764397905759,-0.655913978494624,-0.677924217462932,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","neutral",-0.914,-0.779,"8:8","149/150","I:K:R:L:Q:A",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage4;lineage7","other_mutations_pyrazinamide","GLN",0,"ERR702406","ERR702406","lineage7;lineage4.2","gh","Ghana","pnca_p.lys48gln","A","E","LYS","KA48","pnca_complex.pdb"
|
|
"K48T","L4","PZA","K","K48",48,"T",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","basic","neutral","pos","polar",7.546,-2.085,-1.92,2.8148,0.126,-1.82,63,80,-0.823,8,8,19,0.0805084745762711,"strand",-2.7,6.78,0.0011499209429351,3.77937043282743,3.77937041554348,3.77886521261346,6.25531101162114,58,24,0,0,24,0,0,0,0,2,0,2,0,0,0,0,0,1,0,-1,2,0,0,4,-2,-0.528115501519757,-0.496124031007752,0.102521143073595,0.106418918918919,-0.476439790575916,0.663157894736842,-0.677924217462932,"Destabilising","Destabilising","Destabilising","Stabilising","Destabilising","effect",-0.914,-0.779,"8:8","149/150","I:K:R:L:Q:A",1.32955743902485,0.0083975040006128,0.504450465587511,2.6356550934617,1.34958413760038,10.1533105792859,0.577419461128044,0.0115372080052907,1.93789927736761,1.1946979725449,11.4155701668003,0.0123821507399189,"lineage4","dr_mutations_pyrazinamide","THR",0,"ERR751528","ERR751528","lineage4.3.3","pe","","pnca_p.lys48thr","A","E","LYS","KA48","pnca_complex.pdb"
|
|
"K48T","L4","PZA","K","K48",48,"T",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","basic","neutral","pos","polar",7.546,-2.085,-1.92,2.8148,0.126,-1.82,63,80,-0.823,8,8,19,0.0805084745762711,"strand",-2.7,6.78,0.0011499209429351,3.77937043282743,3.77937041554348,3.77886521261346,6.25531101162114,58,24,0,0,24,0,0,0,0,2,0,2,0,0,0,0,0,1,0,-1,2,0,0,4,-2,-0.528115501519757,-0.496124031007752,0.102521143073595,0.106418918918919,-0.476439790575916,0.663157894736842,-0.677924217462932,"Destabilising","Destabilising","Destabilising","Stabilising","Destabilising","effect",-0.914,-0.779,"8:8","149/150","I:K:R:L:Q:A",1.32955743902485,0.0083975040006128,0.504450465587511,2.6356550934617,1.34958413760038,10.1533105792859,0.577419461128044,0.0115372080052907,1.93789927736761,1.1946979725449,11.4155701668003,0.0123821507399189,"lineage4","dr_mutations_pyrazinamide","THR",0,"ERR2510875","ERR2510875","lineage4.3.3","it","Italy","pnca_p.lys48thr","A","E","LYS","KA48","pnca_complex.pdb"
|
|
"K48T","L3","PZA","K","K48",48,"T",0,"MDR","DM","hydrophobic","hydrophobic","basic","neutral","pos","polar",7.546,-2.085,-1.92,2.8148,0.126,-1.82,63,80,-0.823,8,8,19,0.0805084745762711,"strand",-2.7,6.78,0.0011499209429351,3.77937043282743,3.77937041554348,3.77886521261346,6.25531101162114,58,24,0,0,24,0,0,0,0,2,0,2,0,0,0,0,0,1,0,-1,2,0,0,4,-2,-0.528115501519757,-0.496124031007752,0.102521143073595,0.106418918918919,-0.476439790575916,0.663157894736842,-0.677924217462932,"Destabilising","Destabilising","Destabilising","Stabilising","Destabilising","effect",-0.914,-0.779,"8:8","149/150","I:K:R:L:Q:A",1.32955743902485,0.0083975040006128,0.504450465587511,2.6356550934617,1.34958413760038,10.1533105792859,0.577419461128044,0.0115372080052907,1.93789927736761,1.1946979725449,11.4155701668003,0.0123821507399189,"lineage3","dr_mutations_pyrazinamide","THR",0,"ERR2516821","ERR2516821","lineage3","gb","UK","pnca_p.lys48thr","A","E","LYS","KA48","pnca_complex.pdb"
|
|
"K48T","L4","PZA","K","K48",48,"T",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","basic","neutral","pos","polar",7.546,-2.085,-1.92,2.8148,0.126,-1.82,63,80,-0.823,8,8,19,0.0805084745762711,"strand",-2.7,6.78,0.0011499209429351,3.77937043282743,3.77937041554348,3.77886521261346,6.25531101162114,58,24,0,0,24,0,0,0,0,2,0,2,0,0,0,0,0,1,0,-1,2,0,0,4,-2,-0.528115501519757,-0.496124031007752,0.102521143073595,0.106418918918919,-0.476439790575916,0.663157894736842,-0.677924217462932,"Destabilising","Destabilising","Destabilising","Stabilising","Destabilising","effect",-0.914,-0.779,"8:8","149/150","I:K:R:L:Q:A",1.32955743902485,0.0083975040006128,0.504450465587511,2.6356550934617,1.34958413760038,10.1533105792859,0.577419461128044,0.0115372080052907,1.93789927736761,1.1946979725449,11.4155701668003,0.0123821507399189,"lineage4","dr_mutations_pyrazinamide","THR",0,"ERR1034712","ERR1034712","lineage4.3.3","pe","Peru","pnca_p.lys48thr","A","E","LYS","KA48","pnca_complex.pdb"
|
|
"K48T","L4","PZA","K","K48",48,"T",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","basic","neutral","pos","polar",7.546,-2.085,-1.92,2.8148,0.126,-1.82,63,80,-0.823,8,8,19,0.0805084745762711,"strand",-2.7,6.78,0.0011499209429351,3.77937043282743,3.77937041554348,3.77886521261346,6.25531101162114,58,24,0,0,24,0,0,0,0,2,0,2,0,0,0,0,0,1,0,-1,2,0,0,4,-2,-0.528115501519757,-0.496124031007752,0.102521143073595,0.106418918918919,-0.476439790575916,0.663157894736842,-0.677924217462932,"Destabilising","Destabilising","Destabilising","Stabilising","Destabilising","effect",-0.914,-0.779,"8:8","149/150","I:K:R:L:Q:A",1.32955743902485,0.0083975040006128,0.504450465587511,2.6356550934617,1.34958413760038,10.1533105792859,0.577419461128044,0.0115372080052907,1.93789927736761,1.1946979725449,11.4155701668003,0.0123821507399189,"lineage4","dr_mutations_pyrazinamide","THR",0,"ERR751402","ERR751402","lineage4.3.3","pe","","pnca_p.lys48thr","A","E","LYS","KA48","pnca_complex.pdb"
|
|
"K48T","L4","PZA","K","K48",48,"T",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","basic","neutral","pos","polar",7.546,-2.085,-1.92,2.8148,0.126,-1.82,63,80,-0.823,8,8,19,0.0805084745762711,"strand",-2.7,6.78,0.0011499209429351,3.77937043282743,3.77937041554348,3.77886521261346,6.25531101162114,58,24,0,0,24,0,0,0,0,2,0,2,0,0,0,0,0,1,0,-1,2,0,0,4,-2,-0.528115501519757,-0.496124031007752,0.102521143073595,0.106418918918919,-0.476439790575916,0.663157894736842,-0.677924217462932,"Destabilising","Destabilising","Destabilising","Stabilising","Destabilising","effect",-0.914,-0.779,"8:8","149/150","I:K:R:L:Q:A",1.32955743902485,0.0083975040006128,0.504450465587511,2.6356550934617,1.34958413760038,10.1533105792859,0.577419461128044,0.0115372080052907,1.93789927736761,1.1946979725449,11.4155701668003,0.0123821507399189,"lineage4","dr_mutations_pyrazinamide","THR",0,"ERR751492","ERR751492","lineage4.3.3","pe","","pnca_p.lys48thr","A","E","LYS","KA48","pnca_complex.pdb"
|
|
"K48T","L4","PZA","K","K48",48,"T",1,"Pre-XDR","DM","hydrophobic","hydrophobic","basic","neutral","pos","polar",7.546,-2.085,-1.92,2.8148,0.126,-1.82,63,80,-0.823,8,8,19,0.0805084745762711,"strand",-2.7,6.78,0.0011499209429351,3.77937043282743,3.77937041554348,3.77886521261346,6.25531101162114,58,24,0,0,24,0,0,0,0,2,0,2,0,0,0,0,0,1,0,-1,2,0,0,4,-2,-0.528115501519757,-0.496124031007752,0.102521143073595,0.106418918918919,-0.476439790575916,0.663157894736842,-0.677924217462932,"Destabilising","Destabilising","Destabilising","Stabilising","Destabilising","effect",-0.914,-0.779,"8:8","149/150","I:K:R:L:Q:A",1.32955743902485,0.0083975040006128,0.504450465587511,2.6356550934617,1.34958413760038,10.1533105792859,0.577419461128044,0.0115372080052907,1.93789927736761,1.1946979725449,11.4155701668003,0.0123821507399189,"lineage4","dr_mutations_pyrazinamide","THR",0,"ERR2510872","ERR2510872","lineage4.3.3","it","Italy","pnca_p.lys48thr","A","E","LYS","KA48","pnca_complex.pdb"
|
|
"K48T","L4","PZA","K","K48",48,"T",NA,"XDR","DM","hydrophobic","hydrophobic","basic","neutral","pos","polar",7.546,-2.085,-1.92,2.8148,0.126,-1.82,63,80,-0.823,8,8,19,0.0805084745762711,"strand",-2.7,6.78,0.0011499209429351,3.77937043282743,3.77937041554348,3.77886521261346,6.25531101162114,58,24,0,0,24,0,0,0,0,2,0,2,0,0,0,0,0,1,0,-1,2,0,0,4,-2,-0.528115501519757,-0.496124031007752,0.102521143073595,0.106418918918919,-0.476439790575916,0.663157894736842,-0.677924217462932,"Destabilising","Destabilising","Destabilising","Stabilising","Destabilising","effect",-0.914,-0.779,"8:8","149/150","I:K:R:L:Q:A",1.32955743902485,0.0083975040006128,0.504450465587511,2.6356550934617,1.34958413760038,10.1533105792859,0.577419461128044,0.0115372080052907,1.93789927736761,1.1946979725449,11.4155701668003,0.0123821507399189,"lineage4","dr_mutations_pyrazinamide","THR",0,"ERR775360","ERR775360","lineage4.3.3","pe","","pnca_p.lys48thr","A","E","LYS","KA48","pnca_complex.pdb"
|
|
"K48T","L4","PZA","K","K48",48,"T",1,"XDR","DM","hydrophobic","hydrophobic","basic","neutral","pos","polar",7.546,-2.085,-1.92,2.8148,0.126,-1.82,63,80,-0.823,8,8,19,0.0805084745762711,"strand",-2.7,6.78,0.0011499209429351,3.77937043282743,3.77937041554348,3.77886521261346,6.25531101162114,58,24,0,0,24,0,0,0,0,2,0,2,0,0,0,0,0,1,0,-1,2,0,0,4,-2,-0.528115501519757,-0.496124031007752,0.102521143073595,0.106418918918919,-0.476439790575916,0.663157894736842,-0.677924217462932,"Destabilising","Destabilising","Destabilising","Stabilising","Destabilising","effect",-0.914,-0.779,"8:8","149/150","I:K:R:L:Q:A",1.32955743902485,0.0083975040006128,0.504450465587511,2.6356550934617,1.34958413760038,10.1533105792859,0.577419461128044,0.0115372080052907,1.93789927736761,1.1946979725449,11.4155701668003,0.0123821507399189,"lineage4","dr_mutations_pyrazinamide","THR",0,"ERR2516705","ERR2516705","lineage4.3.3","pe","Peru","pnca_p.lys48thr","A","E","LYS","KA48","pnca_complex.pdb"
|
|
"K48T","L4","PZA","K","K48",48,"T",1,"Pre-XDR","DM","hydrophobic","hydrophobic","basic","neutral","pos","polar",7.546,-2.085,-1.92,2.8148,0.126,-1.82,63,80,-0.823,8,8,19,0.0805084745762711,"strand",-2.7,6.78,0.0011499209429351,3.77937043282743,3.77937041554348,3.77886521261346,6.25531101162114,58,24,0,0,24,0,0,0,0,2,0,2,0,0,0,0,0,1,0,-1,2,0,0,4,-2,-0.528115501519757,-0.496124031007752,0.102521143073595,0.106418918918919,-0.476439790575916,0.663157894736842,-0.677924217462932,"Destabilising","Destabilising","Destabilising","Stabilising","Destabilising","effect",-0.914,-0.779,"8:8","149/150","I:K:R:L:Q:A",1.32955743902485,0.0083975040006128,0.504450465587511,2.6356550934617,1.34958413760038,10.1533105792859,0.577419461128044,0.0115372080052907,1.93789927736761,1.1946979725449,11.4155701668003,0.0123821507399189,"lineage4","dr_mutations_pyrazinamide","THR",0,"ERR2516544","ERR2516544","lineage4.3.3","pe","Peru","pnca_p.lys48thr","A","E","LYS","KA48","pnca_complex.pdb"
|
|
"K48T","L2","PZA","K","K48",48,"T",0,"MDR","DM","hydrophobic","hydrophobic","basic","neutral","pos","polar",7.546,-2.085,-1.92,2.8148,0.126,-1.82,63,80,-0.823,8,8,19,0.0805084745762711,"strand",-2.7,6.78,0.0011499209429351,3.77937043282743,3.77937041554348,3.77886521261346,6.25531101162114,58,24,0,0,24,0,0,0,0,2,0,2,0,0,0,0,0,1,0,-1,2,0,0,4,-2,-0.528115501519757,-0.496124031007752,0.102521143073595,0.106418918918919,-0.476439790575916,0.663157894736842,-0.677924217462932,"Destabilising","Destabilising","Destabilising","Stabilising","Destabilising","effect",-0.914,-0.779,"8:8","149/150","I:K:R:L:Q:A",1.32955743902485,0.0083975040006128,0.504450465587511,2.6356550934617,1.34958413760038,10.1533105792859,0.577419461128044,0.0115372080052907,1.93789927736761,1.1946979725449,11.4155701668003,0.0123821507399189,"lineage2","dr_mutations_pyrazinamide","THR",0,"SAMN02053772","SRR833147_SRR833085","lineage2.2.1","za","South Africa","pnca_p.lys48thr","A","E","LYS","KA48","pnca_complex.pdb"
|
|
"K48T","L4","PZA","K","K48",48,"T",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","basic","neutral","pos","polar",7.546,-2.085,-1.92,2.8148,0.126,-1.82,63,80,-0.823,8,8,19,0.0805084745762711,"strand",-2.7,6.78,0.0011499209429351,3.77937043282743,3.77937041554348,3.77886521261346,6.25531101162114,58,24,0,0,24,0,0,0,0,2,0,2,0,0,0,0,0,1,0,-1,2,0,0,4,-2,-0.528115501519757,-0.496124031007752,0.102521143073595,0.106418918918919,-0.476439790575916,0.663157894736842,-0.677924217462932,"Destabilising","Destabilising","Destabilising","Stabilising","Destabilising","effect",-0.914,-0.779,"8:8","149/150","I:K:R:L:Q:A",1.32955743902485,0.0083975040006128,0.504450465587511,2.6356550934617,1.34958413760038,10.1533105792859,0.577419461128044,0.0115372080052907,1.93789927736761,1.1946979725449,11.4155701668003,0.0123821507399189,"lineage4","dr_mutations_pyrazinamide","THR",0,"ERR751504","ERR751504","lineage4.3.3","pe","","pnca_p.lys48thr","A","E","LYS","KA48","pnca_complex.pdb"
|
|
"K48T","L4","PZA","K","K48",48,"T",0,"XDR","DM","hydrophobic","hydrophobic","basic","neutral","pos","polar",7.546,-2.085,-1.92,2.8148,0.126,-1.82,63,80,-0.823,8,8,19,0.0805084745762711,"strand",-2.7,6.78,0.0011499209429351,3.77937043282743,3.77937041554348,3.77886521261346,6.25531101162114,58,24,0,0,24,0,0,0,0,2,0,2,0,0,0,0,0,1,0,-1,2,0,0,4,-2,-0.528115501519757,-0.496124031007752,0.102521143073595,0.106418918918919,-0.476439790575916,0.663157894736842,-0.677924217462932,"Destabilising","Destabilising","Destabilising","Stabilising","Destabilising","effect",-0.914,-0.779,"8:8","149/150","I:K:R:L:Q:A",1.32955743902485,0.0083975040006128,0.504450465587511,2.6356550934617,1.34958413760038,10.1533105792859,0.577419461128044,0.0115372080052907,1.93789927736761,1.1946979725449,11.4155701668003,0.0123821507399189,"lineage4","dr_mutations_pyrazinamide","THR",0,"ERR2516614","ERR2516614","lineage4.3.3","pe","Peru","pnca_p.lys48thr","A","E","LYS","KA48","pnca_complex.pdb"
|
|
"K48T","L4","PZA","K","K48",48,"T",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","basic","neutral","pos","polar",7.546,-2.085,-1.92,2.8148,0.126,-1.82,63,80,-0.823,8,8,19,0.0805084745762711,"strand",-2.7,6.78,0.0011499209429351,3.77937043282743,3.77937041554348,3.77886521261346,6.25531101162114,58,24,0,0,24,0,0,0,0,2,0,2,0,0,0,0,0,1,0,-1,2,0,0,4,-2,-0.528115501519757,-0.496124031007752,0.102521143073595,0.106418918918919,-0.476439790575916,0.663157894736842,-0.677924217462932,"Destabilising","Destabilising","Destabilising","Stabilising","Destabilising","effect",-0.914,-0.779,"8:8","149/150","I:K:R:L:Q:A",1.32955743902485,0.0083975040006128,0.504450465587511,2.6356550934617,1.34958413760038,10.1533105792859,0.577419461128044,0.0115372080052907,1.93789927736761,1.1946979725449,11.4155701668003,0.0123821507399189,"lineage4","dr_mutations_pyrazinamide","THR",0,"ERR2510874","ERR2510874","lineage4.3.3","it","Italy","pnca_p.lys48thr","A","E","LYS","KA48","pnca_complex.pdb"
|
|
"K48T","L4","PZA","K","K48",48,"T",NA,"XDR","DM","hydrophobic","hydrophobic","basic","neutral","pos","polar",7.546,-2.085,-1.92,2.8148,0.126,-1.82,63,80,-0.823,8,8,19,0.0805084745762711,"strand",-2.7,6.78,0.0011499209429351,3.77937043282743,3.77937041554348,3.77886521261346,6.25531101162114,58,24,0,0,24,0,0,0,0,2,0,2,0,0,0,0,0,1,0,-1,2,0,0,4,-2,-0.528115501519757,-0.496124031007752,0.102521143073595,0.106418918918919,-0.476439790575916,0.663157894736842,-0.677924217462932,"Destabilising","Destabilising","Destabilising","Stabilising","Destabilising","effect",-0.914,-0.779,"8:8","149/150","I:K:R:L:Q:A",1.32955743902485,0.0083975040006128,0.504450465587511,2.6356550934617,1.34958413760038,10.1533105792859,0.577419461128044,0.0115372080052907,1.93789927736761,1.1946979725449,11.4155701668003,0.0123821507399189,"lineage4","dr_mutations_pyrazinamide","THR",0,"ERR2516649","ERR2516649","lineage4.3.3","pe","Peru","pnca_p.lys48thr","A","E","LYS","KA48","pnca_complex.pdb"
|
|
"K48T","L4","PZA","K","K48",48,"T",0,"Pre-XDR","DM","hydrophobic","hydrophobic","basic","neutral","pos","polar",7.546,-2.085,-1.92,2.8148,0.126,-1.82,63,80,-0.823,8,8,19,0.0805084745762711,"strand",-2.7,6.78,0.0011499209429351,3.77937043282743,3.77937041554348,3.77886521261346,6.25531101162114,58,24,0,0,24,0,0,0,0,2,0,2,0,0,0,0,0,1,0,-1,2,0,0,4,-2,-0.528115501519757,-0.496124031007752,0.102521143073595,0.106418918918919,-0.476439790575916,0.663157894736842,-0.677924217462932,"Destabilising","Destabilising","Destabilising","Stabilising","Destabilising","effect",-0.914,-0.779,"8:8","149/150","I:K:R:L:Q:A",1.32955743902485,0.0083975040006128,0.504450465587511,2.6356550934617,1.34958413760038,10.1533105792859,0.577419461128044,0.0115372080052907,1.93789927736761,1.1946979725449,11.4155701668003,0.0123821507399189,"lineage4","dr_mutations_pyrazinamide","THR",0,"ERR2516429","ERR2516429","lineage4.3.3","pe","Peru","pnca_p.lys48thr","A","E","LYS","KA48","pnca_complex.pdb"
|
|
"K48T","L4","PZA","K","K48",48,"T",1,"Pre-XDR","DM","hydrophobic","hydrophobic","basic","neutral","pos","polar",7.546,-2.085,-1.92,2.8148,0.126,-1.82,63,80,-0.823,8,8,19,0.0805084745762711,"strand",-2.7,6.78,0.0011499209429351,3.77937043282743,3.77937041554348,3.77886521261346,6.25531101162114,58,24,0,0,24,0,0,0,0,2,0,2,0,0,0,0,0,1,0,-1,2,0,0,4,-2,-0.528115501519757,-0.496124031007752,0.102521143073595,0.106418918918919,-0.476439790575916,0.663157894736842,-0.677924217462932,"Destabilising","Destabilising","Destabilising","Stabilising","Destabilising","effect",-0.914,-0.779,"8:8","149/150","I:K:R:L:Q:A",1.32955743902485,0.0083975040006128,0.504450465587511,2.6356550934617,1.34958413760038,10.1533105792859,0.577419461128044,0.0115372080052907,1.93789927736761,1.1946979725449,11.4155701668003,0.0123821507399189,"lineage4","dr_mutations_pyrazinamide","THR",0,"ERR1034734","ERR1034734","lineage4.3.3","pe","Peru","pnca_p.lys48thr","A","E","LYS","KA48","pnca_complex.pdb"
|
|
"K48T","L4","PZA","K","K48",48,"T",1,"Pre-XDR","DM","hydrophobic","hydrophobic","basic","neutral","pos","polar",7.546,-2.085,-1.92,2.8148,0.126,-1.82,63,80,-0.823,8,8,19,0.0805084745762711,"strand",-2.7,6.78,0.0011499209429351,3.77937043282743,3.77937041554348,3.77886521261346,6.25531101162114,58,24,0,0,24,0,0,0,0,2,0,2,0,0,0,0,0,1,0,-1,2,0,0,4,-2,-0.528115501519757,-0.496124031007752,0.102521143073595,0.106418918918919,-0.476439790575916,0.663157894736842,-0.677924217462932,"Destabilising","Destabilising","Destabilising","Stabilising","Destabilising","effect",-0.914,-0.779,"8:8","149/150","I:K:R:L:Q:A",1.32955743902485,0.0083975040006128,0.504450465587511,2.6356550934617,1.34958413760038,10.1533105792859,0.577419461128044,0.0115372080052907,1.93789927736761,1.1946979725449,11.4155701668003,0.0123821507399189,"lineage4","dr_mutations_pyrazinamide","THR",0,"ERR2510695","ERR2510695","lineage4.3.3","it","Italy","pnca_p.lys48thr","A","E","LYS","KA48","pnca_complex.pdb"
|
|
"K48T","L4","PZA","K","K48",48,"T",0,"MDR","DM","hydrophobic","hydrophobic","basic","neutral","pos","polar",7.546,-2.085,-1.92,2.8148,0.126,-1.82,63,80,-0.823,8,8,19,0.0805084745762711,"strand",-2.7,6.78,0.0011499209429351,3.77937043282743,3.77937041554348,3.77886521261346,6.25531101162114,58,24,0,0,24,0,0,0,0,2,0,2,0,0,0,0,0,1,0,-1,2,0,0,4,-2,-0.528115501519757,-0.496124031007752,0.102521143073595,0.106418918918919,-0.476439790575916,0.663157894736842,-0.677924217462932,"Destabilising","Destabilising","Destabilising","Stabilising","Destabilising","effect",-0.914,-0.779,"8:8","149/150","I:K:R:L:Q:A",1.32955743902485,0.0083975040006128,0.504450465587511,2.6356550934617,1.34958413760038,10.1533105792859,0.577419461128044,0.0115372080052907,1.93789927736761,1.1946979725449,11.4155701668003,0.0123821507399189,"lineage4","dr_mutations_pyrazinamide","THR",0,"ERR2510793","ERR2510793","lineage4.3.3","it","Italy","pnca_p.lys48thr","A","E","LYS","KA48","pnca_complex.pdb"
|
|
"K48T","L4","PZA","K","K48",48,"T",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","basic","neutral","pos","polar",7.546,-2.085,-1.92,2.8148,0.126,-1.82,63,80,-0.823,8,8,19,0.0805084745762711,"strand",-2.7,6.78,0.0011499209429351,3.77937043282743,3.77937041554348,3.77886521261346,6.25531101162114,58,24,0,0,24,0,0,0,0,2,0,2,0,0,0,0,0,1,0,-1,2,0,0,4,-2,-0.528115501519757,-0.496124031007752,0.102521143073595,0.106418918918919,-0.476439790575916,0.663157894736842,-0.677924217462932,"Destabilising","Destabilising","Destabilising","Stabilising","Destabilising","effect",-0.914,-0.779,"8:8","149/150","I:K:R:L:Q:A",1.32955743902485,0.0083975040006128,0.504450465587511,2.6356550934617,1.34958413760038,10.1533105792859,0.577419461128044,0.0115372080052907,1.93789927736761,1.1946979725449,11.4155701668003,0.0123821507399189,"lineage4","dr_mutations_pyrazinamide","THR",0,"ERR775365","ERR775365","lineage4.3.3","pe","","pnca_p.lys48thr","A","E","LYS","KA48","pnca_complex.pdb"
|
|
"K48T","L3","PZA","K","K48",48,"T",0,"MDR","DM","hydrophobic","hydrophobic","basic","neutral","pos","polar",7.546,-2.085,-1.92,2.8148,0.126,-1.82,63,80,-0.823,8,8,19,0.0805084745762711,"strand",-2.7,6.78,0.0011499209429351,3.77937043282743,3.77937041554348,3.77886521261346,6.25531101162114,58,24,0,0,24,0,0,0,0,2,0,2,0,0,0,0,0,1,0,-1,2,0,0,4,-2,-0.528115501519757,-0.496124031007752,0.102521143073595,0.106418918918919,-0.476439790575916,0.663157894736842,-0.677924217462932,"Destabilising","Destabilising","Destabilising","Stabilising","Destabilising","effect",-0.914,-0.779,"8:8","149/150","I:K:R:L:Q:A",1.32955743902485,0.0083975040006128,0.504450465587511,2.6356550934617,1.34958413760038,10.1533105792859,0.577419461128044,0.0115372080052907,1.93789927736761,1.1946979725449,11.4155701668003,0.0123821507399189,"lineage3","dr_mutations_pyrazinamide","THR",0,"SRR6339667","SRR6339667","lineage3.1.2","au","Australia","pnca_p.lys48thr","A","E","LYS","KA48","pnca_complex.pdb"
|
|
"K48T","L4","PZA","K","K48",48,"T",NA,"XDR","DM","hydrophobic","hydrophobic","basic","neutral","pos","polar",7.546,-2.085,-1.92,2.8148,0.126,-1.82,63,80,-0.823,8,8,19,0.0805084745762711,"strand",-2.7,6.78,0.0011499209429351,3.77937043282743,3.77937041554348,3.77886521261346,6.25531101162114,58,24,0,0,24,0,0,0,0,2,0,2,0,0,0,0,0,1,0,-1,2,0,0,4,-2,-0.528115501519757,-0.496124031007752,0.102521143073595,0.106418918918919,-0.476439790575916,0.663157894736842,-0.677924217462932,"Destabilising","Destabilising","Destabilising","Stabilising","Destabilising","effect",-0.914,-0.779,"8:8","149/150","I:K:R:L:Q:A",1.32955743902485,0.0083975040006128,0.504450465587511,2.6356550934617,1.34958413760038,10.1533105792859,0.577419461128044,0.0115372080052907,1.93789927736761,1.1946979725449,11.4155701668003,0.0123821507399189,"lineage4","dr_mutations_pyrazinamide","THR",0,"ERR2516690","ERR2516690","lineage4.3.3","pe","Peru","pnca_p.lys48thr","A","E","LYS","KA48","pnca_complex.pdb"
|
|
"K48T","L4","PZA","K","K48",48,"T",1,"Pre-XDR","DM","hydrophobic","hydrophobic","basic","neutral","pos","polar",7.546,-2.085,-1.92,2.8148,0.126,-1.82,63,80,-0.823,8,8,19,0.0805084745762711,"strand",-2.7,6.78,0.0011499209429351,3.77937043282743,3.77937041554348,3.77886521261346,6.25531101162114,58,24,0,0,24,0,0,0,0,2,0,2,0,0,0,0,0,1,0,-1,2,0,0,4,-2,-0.528115501519757,-0.496124031007752,0.102521143073595,0.106418918918919,-0.476439790575916,0.663157894736842,-0.677924217462932,"Destabilising","Destabilising","Destabilising","Stabilising","Destabilising","effect",-0.914,-0.779,"8:8","149/150","I:K:R:L:Q:A",1.32955743902485,0.0083975040006128,0.504450465587511,2.6356550934617,1.34958413760038,10.1533105792859,0.577419461128044,0.0115372080052907,1.93789927736761,1.1946979725449,11.4155701668003,0.0123821507399189,"lineage4","dr_mutations_pyrazinamide","THR",0,"ERR2510734","ERR2510734","lineage4.3.3","it","Italy","pnca_p.lys48thr","A","E","LYS","KA48","pnca_complex.pdb"
|
|
"K48T","L4","PZA","K","K48",48,"T",1,"XDR","DM","hydrophobic","hydrophobic","basic","neutral","pos","polar",7.546,-2.085,-1.92,2.8148,0.126,-1.82,63,80,-0.823,8,8,19,0.0805084745762711,"strand",-2.7,6.78,0.0011499209429351,3.77937043282743,3.77937041554348,3.77886521261346,6.25531101162114,58,24,0,0,24,0,0,0,0,2,0,2,0,0,0,0,0,1,0,-1,2,0,0,4,-2,-0.528115501519757,-0.496124031007752,0.102521143073595,0.106418918918919,-0.476439790575916,0.663157894736842,-0.677924217462932,"Destabilising","Destabilising","Destabilising","Stabilising","Destabilising","effect",-0.914,-0.779,"8:8","149/150","I:K:R:L:Q:A",1.32955743902485,0.0083975040006128,0.504450465587511,2.6356550934617,1.34958413760038,10.1533105792859,0.577419461128044,0.0115372080052907,1.93789927736761,1.1946979725449,11.4155701668003,0.0123821507399189,"lineage4","dr_mutations_pyrazinamide","THR",0,"ERR2516646","ERR2516646","lineage4.3.3","pe","Peru","pnca_p.lys48thr","A","E","LYS","KA48","pnca_complex.pdb"
|
|
"K48T","L4","PZA","K","K48",48,"T",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","basic","neutral","pos","polar",7.546,-2.085,-1.92,2.8148,0.126,-1.82,63,80,-0.823,8,8,19,0.0805084745762711,"strand",-2.7,6.78,0.0011499209429351,3.77937043282743,3.77937041554348,3.77886521261346,6.25531101162114,58,24,0,0,24,0,0,0,0,2,0,2,0,0,0,0,0,1,0,-1,2,0,0,4,-2,-0.528115501519757,-0.496124031007752,0.102521143073595,0.106418918918919,-0.476439790575916,0.663157894736842,-0.677924217462932,"Destabilising","Destabilising","Destabilising","Stabilising","Destabilising","effect",-0.914,-0.779,"8:8","149/150","I:K:R:L:Q:A",1.32955743902485,0.0083975040006128,0.504450465587511,2.6356550934617,1.34958413760038,10.1533105792859,0.577419461128044,0.0115372080052907,1.93789927736761,1.1946979725449,11.4155701668003,0.0123821507399189,"lineage4","dr_mutations_pyrazinamide","THR",0,"ERR751448","ERR751448","lineage4.3.3","pe","","pnca_p.lys48thr","A","E","LYS","KA48","pnca_complex.pdb"
|
|
"K48T","L4","PZA","K","K48",48,"T",0,"XDR","DM","hydrophobic","hydrophobic","basic","neutral","pos","polar",7.546,-2.085,-1.92,2.8148,0.126,-1.82,63,80,-0.823,8,8,19,0.0805084745762711,"strand",-2.7,6.78,0.0011499209429351,3.77937043282743,3.77937041554348,3.77886521261346,6.25531101162114,58,24,0,0,24,0,0,0,0,2,0,2,0,0,0,0,0,1,0,-1,2,0,0,4,-2,-0.528115501519757,-0.496124031007752,0.102521143073595,0.106418918918919,-0.476439790575916,0.663157894736842,-0.677924217462932,"Destabilising","Destabilising","Destabilising","Stabilising","Destabilising","effect",-0.914,-0.779,"8:8","149/150","I:K:R:L:Q:A",1.32955743902485,0.0083975040006128,0.504450465587511,2.6356550934617,1.34958413760038,10.1533105792859,0.577419461128044,0.0115372080052907,1.93789927736761,1.1946979725449,11.4155701668003,0.0123821507399189,"lineage4","dr_mutations_pyrazinamide","THR",0,"ERR2516595","ERR2516595","lineage4.3.3","pe","Peru","pnca_p.lys48thr","A","E","LYS","KA48","pnca_complex.pdb"
|
|
"K48T","L4","PZA","K","K48",48,"T",0,"Pre-XDR","DM","hydrophobic","hydrophobic","basic","neutral","pos","polar",7.546,-2.085,-1.92,2.8148,0.126,-1.82,63,80,-0.823,8,8,19,0.0805084745762711,"strand",-2.7,6.78,0.0011499209429351,3.77937043282743,3.77937041554348,3.77886521261346,6.25531101162114,58,24,0,0,24,0,0,0,0,2,0,2,0,0,0,0,0,1,0,-1,2,0,0,4,-2,-0.528115501519757,-0.496124031007752,0.102521143073595,0.106418918918919,-0.476439790575916,0.663157894736842,-0.677924217462932,"Destabilising","Destabilising","Destabilising","Stabilising","Destabilising","effect",-0.914,-0.779,"8:8","149/150","I:K:R:L:Q:A",1.32955743902485,0.0083975040006128,0.504450465587511,2.6356550934617,1.34958413760038,10.1533105792859,0.577419461128044,0.0115372080052907,1.93789927736761,1.1946979725449,11.4155701668003,0.0123821507399189,"lineage4","dr_mutations_pyrazinamide","THR",0,"ERR2516460","ERR2516460","lineage4.3.3","pe","Peru","pnca_p.lys48thr","A","E","LYS","KA48","pnca_complex.pdb"
|
|
"K48T","L4","PZA","K","K48",48,"T",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","basic","neutral","pos","polar",7.546,-2.085,-1.92,2.8148,0.126,-1.82,63,80,-0.823,8,8,19,0.0805084745762711,"strand",-2.7,6.78,0.0011499209429351,3.77937043282743,3.77937041554348,3.77886521261346,6.25531101162114,58,24,0,0,24,0,0,0,0,2,0,2,0,0,0,0,0,1,0,-1,2,0,0,4,-2,-0.528115501519757,-0.496124031007752,0.102521143073595,0.106418918918919,-0.476439790575916,0.663157894736842,-0.677924217462932,"Destabilising","Destabilising","Destabilising","Stabilising","Destabilising","effect",-0.914,-0.779,"8:8","149/150","I:K:R:L:Q:A",1.32955743902485,0.0083975040006128,0.504450465587511,2.6356550934617,1.34958413760038,10.1533105792859,0.577419461128044,0.0115372080052907,1.93789927736761,1.1946979725449,11.4155701668003,0.0123821507399189,"lineage4","dr_mutations_pyrazinamide","THR",0,"ERR751444","ERR751444","lineage4.3.3","pe","","pnca_p.lys48thr","A","E","LYS","KA48","pnca_complex.pdb"
|
|
"K48T","L4","PZA","K","K48",48,"T",0,"XDR","DM","hydrophobic","hydrophobic","basic","neutral","pos","polar",7.546,-2.085,-1.92,2.8148,0.126,-1.82,63,80,-0.823,8,8,19,0.0805084745762711,"strand",-2.7,6.78,0.0011499209429351,3.77937043282743,3.77937041554348,3.77886521261346,6.25531101162114,58,24,0,0,24,0,0,0,0,2,0,2,0,0,0,0,0,1,0,-1,2,0,0,4,-2,-0.528115501519757,-0.496124031007752,0.102521143073595,0.106418918918919,-0.476439790575916,0.663157894736842,-0.677924217462932,"Destabilising","Destabilising","Destabilising","Stabilising","Destabilising","effect",-0.914,-0.779,"8:8","149/150","I:K:R:L:Q:A",1.32955743902485,0.0083975040006128,0.504450465587511,2.6356550934617,1.34958413760038,10.1533105792859,0.577419461128044,0.0115372080052907,1.93789927736761,1.1946979725449,11.4155701668003,0.0123821507399189,"lineage4","dr_mutations_pyrazinamide","THR",0,"ERR2516608","ERR2516608","lineage4.3.3","pe","Peru","pnca_p.lys48thr","A","E","LYS","KA48","pnca_complex.pdb"
|
|
"D49A","L2","PZA","D","D49",49,"A",1,"MDR","DM","hydrophilic","hydrophobic","acidic","non-polar","neg","non-polar",3.452,-3.348,-0.451,-2.06724,-1.72,-1.56,73,85,-1.188,9,9,7,0.0362694300518134,"strand",-1.53333333333333,7.89,0.0004312203536006,58.3312262958281,1393450.9402217,Inf,23.547488635408,20,28,0,0,28,0,0,0,0,0,0,0,0,0,0,0,0,-5,0,0,-5,0,0,2,3,-0.848024316109423,-0.116537467700258,-0.397454433592248,-0.293265132139812,-0.408376963350785,0.768421052631579,-0.978583196046129,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","T:D",14.1472939191285,0.915018435774987,132.576060676241,0.106710773023171,4.17896182049081,NA,1.7659011066874,2.48532104922106e-05,4.60461750194108,5.71767556863798,Inf,1.21868387173808e-06,"lineage2","dr_mutations_pyrazinamide","ALA",0,"ERR2517097","ERR2517097","lineage2.2.1.2","gb","UK","pnca_p.asp49ala","A","E","ASP","DA49","pnca_complex.pdb"
|
|
"D49A","L2","PZA","D","D49",49,"A",1,"MDR","DM","hydrophilic","hydrophobic","acidic","non-polar","neg","non-polar",3.452,-3.348,-0.451,-2.06724,-1.72,-1.56,73,85,-1.188,9,9,7,0.0362694300518134,"strand",-1.53333333333333,7.89,0.0004312203536006,58.3312262958281,1393450.9402217,Inf,23.547488635408,20,28,0,0,28,0,0,0,0,0,0,0,0,0,0,0,0,-5,0,0,-5,0,0,2,3,-0.848024316109423,-0.116537467700258,-0.397454433592248,-0.293265132139812,-0.408376963350785,0.768421052631579,-0.978583196046129,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","T:D",14.1472939191285,0.915018435774987,132.576060676241,0.106710773023171,4.17896182049081,NA,1.7659011066874,2.48532104922106e-05,4.60461750194108,5.71767556863798,Inf,1.21868387173808e-06,"lineage2","dr_mutations_pyrazinamide","ALA",0,"ERR2516917","ERR2516917","lineage2.2.1.2","gb","UK","pnca_p.asp49ala","A","E","ASP","DA49","pnca_complex.pdb"
|
|
"D49A","L2","PZA","D","D49",49,"A",NA,"Pre-XDR","DM","hydrophilic","hydrophobic","acidic","non-polar","neg","non-polar",3.452,-3.348,-0.451,-2.06724,-1.72,-1.56,73,85,-1.188,9,9,7,0.0362694300518134,"strand",-1.53333333333333,7.89,0.0004312203536006,58.3312262958281,1393450.9402217,Inf,23.547488635408,20,28,0,0,28,0,0,0,0,0,0,0,0,0,0,0,0,-5,0,0,-5,0,0,2,3,-0.848024316109423,-0.116537467700258,-0.397454433592248,-0.293265132139812,-0.408376963350785,0.768421052631579,-0.978583196046129,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","T:D",14.1472939191285,0.915018435774987,132.576060676241,0.106710773023171,4.17896182049081,NA,1.7659011066874,2.48532104922106e-05,4.60461750194108,5.71767556863798,Inf,1.21868387173808e-06,"lineage2","dr_mutations_pyrazinamide","ALA",0,"SRR671796,BGI_LN228","SRR671796","lineage2.2.1","cn","China","pnca_p.asp49ala","A","E","ASP","DA49","pnca_complex.pdb"
|
|
"D49A","L2","PZA","D","D49",49,"A",NA,"MDR","DM","hydrophilic","hydrophobic","acidic","non-polar","neg","non-polar",3.452,-3.348,-0.451,-2.06724,-1.72,-1.56,73,85,-1.188,9,9,7,0.0362694300518134,"strand",-1.53333333333333,7.89,0.0004312203536006,58.3312262958281,1393450.9402217,Inf,23.547488635408,20,28,0,0,28,0,0,0,0,0,0,0,0,0,0,0,0,-5,0,0,-5,0,0,2,3,-0.848024316109423,-0.116537467700258,-0.397454433592248,-0.293265132139812,-0.408376963350785,0.768421052631579,-0.978583196046129,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","T:D",14.1472939191285,0.915018435774987,132.576060676241,0.106710773023171,4.17896182049081,NA,1.7659011066874,2.48532104922106e-05,4.60461750194108,5.71767556863798,Inf,1.21868387173808e-06,"lineage2","dr_mutations_pyrazinamide","ALA",0,"ERR1023516","ERR1023516","lineage2.2.1.1","","","pnca_p.asp49ala","A","E","ASP","DA49","pnca_complex.pdb"
|
|
"D49A","L2","PZA","D","D49",49,"A",1,"Pre-XDR","DM","hydrophilic","hydrophobic","acidic","non-polar","neg","non-polar",3.452,-3.348,-0.451,-2.06724,-1.72,-1.56,73,85,-1.188,9,9,7,0.0362694300518134,"strand",-1.53333333333333,7.89,0.0004312203536006,58.3312262958281,1393450.9402217,Inf,23.547488635408,20,28,0,0,28,0,0,0,0,0,0,0,0,0,0,0,0,-5,0,0,-5,0,0,2,3,-0.848024316109423,-0.116537467700258,-0.397454433592248,-0.293265132139812,-0.408376963350785,0.768421052631579,-0.978583196046129,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","T:D",14.1472939191285,0.915018435774987,132.576060676241,0.106710773023171,4.17896182049081,NA,1.7659011066874,2.48532104922106e-05,4.60461750194108,5.71767556863798,Inf,1.21868387173808e-06,"lineage2","dr_mutations_pyrazinamide","ALA",0,"ERR2516209","ERR2516209","lineage2.2.1","be","Belgium","pnca_p.asp49ala","A","E","ASP","DA49","pnca_complex.pdb"
|
|
"D49A","L4","PZA","D","D49",49,"A",NA,"Pre-XDR","DM","hydrophilic","hydrophobic","acidic","non-polar","neg","non-polar",3.452,-3.348,-0.451,-2.06724,-1.72,-1.56,73,85,-1.188,9,9,7,0.0362694300518134,"strand",-1.53333333333333,7.89,0.0004312203536006,58.3312262958281,1393450.9402217,Inf,23.547488635408,20,28,0,0,28,0,0,0,0,0,0,0,0,0,0,0,0,-5,0,0,-5,0,0,2,3,-0.848024316109423,-0.116537467700258,-0.397454433592248,-0.293265132139812,-0.408376963350785,0.768421052631579,-0.978583196046129,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","T:D",14.1472939191285,0.915018435774987,132.576060676241,0.106710773023171,4.17896182049081,NA,1.7659011066874,2.48532104922106e-05,4.60461750194108,5.71767556863798,Inf,1.21868387173808e-06,"lineage4","dr_mutations_pyrazinamide","ALA",0,"SAMN02414939","SRR1166926_SRR1162886_SRR1165557_SRR1165525","lineage4.1.1.1","se","Sweden","pnca_p.asp49ala","A","E","ASP","DA49","pnca_complex.pdb"
|
|
"D49A","L2","PZA","D","D49",49,"A",1,"Pre-XDR","DM","hydrophilic","hydrophobic","acidic","non-polar","neg","non-polar",3.452,-3.348,-0.451,-2.06724,-1.72,-1.56,73,85,-1.188,9,9,7,0.0362694300518134,"strand",-1.53333333333333,7.89,0.0004312203536006,58.3312262958281,1393450.9402217,Inf,23.547488635408,20,28,0,0,28,0,0,0,0,0,0,0,0,0,0,0,0,-5,0,0,-5,0,0,2,3,-0.848024316109423,-0.116537467700258,-0.397454433592248,-0.293265132139812,-0.408376963350785,0.768421052631579,-0.978583196046129,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","T:D",14.1472939191285,0.915018435774987,132.576060676241,0.106710773023171,4.17896182049081,NA,1.7659011066874,2.48532104922106e-05,4.60461750194108,5.71767556863798,Inf,1.21868387173808e-06,"lineage2","dr_mutations_pyrazinamide","ALA",0,"SRR2328057","SRR2328057","lineage2.2.1","au","Australia","pnca_p.asp49ala","A","E","ASP","DA49","pnca_complex.pdb"
|
|
"D49A","L2","PZA","D","D49",49,"A",NA,"MDR","DM","hydrophilic","hydrophobic","acidic","non-polar","neg","non-polar",3.452,-3.348,-0.451,-2.06724,-1.72,-1.56,73,85,-1.188,9,9,7,0.0362694300518134,"strand",-1.53333333333333,7.89,0.0004312203536006,58.3312262958281,1393450.9402217,Inf,23.547488635408,20,28,0,0,28,0,0,0,0,0,0,0,0,0,0,0,0,-5,0,0,-5,0,0,2,3,-0.848024316109423,-0.116537467700258,-0.397454433592248,-0.293265132139812,-0.408376963350785,0.768421052631579,-0.978583196046129,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","T:D",14.1472939191285,0.915018435774987,132.576060676241,0.106710773023171,4.17896182049081,NA,1.7659011066874,2.48532104922106e-05,4.60461750194108,5.71767556863798,Inf,1.21868387173808e-06,"lineage2","dr_mutations_pyrazinamide","ALA",0,"ERR1023442","ERR1023442","lineage2.2.1.1","","","pnca_p.asp49ala","A","E","ASP","DA49","pnca_complex.pdb"
|
|
"D49A","L4","PZA","D","D49",49,"A",NA,"MDR","DM","hydrophilic","hydrophobic","acidic","non-polar","neg","non-polar",3.452,-3.348,-0.451,-2.06724,-1.72,-1.56,73,85,-1.188,9,9,7,0.0362694300518134,"strand",-1.53333333333333,7.89,0.0004312203536006,58.3312262958281,1393450.9402217,Inf,23.547488635408,20,28,0,0,28,0,0,0,0,0,0,0,0,0,0,0,0,-5,0,0,-5,0,0,2,3,-0.848024316109423,-0.116537467700258,-0.397454433592248,-0.293265132139812,-0.408376963350785,0.768421052631579,-0.978583196046129,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","T:D",14.1472939191285,0.915018435774987,132.576060676241,0.106710773023171,4.17896182049081,NA,1.7659011066874,2.48532104922106e-05,4.60461750194108,5.71767556863798,Inf,1.21868387173808e-06,"lineage4","dr_mutations_pyrazinamide","ALA",0,"SRR5818579","SRR5818579","lineage4.1.1.1","dj","Djibouti","pnca_p.asp49ala","A","E","ASP","DA49","pnca_complex.pdb"
|
|
"D49A","L2","PZA","D","D49",49,"A",NA,"MDR","DM","hydrophilic","hydrophobic","acidic","non-polar","neg","non-polar",3.452,-3.348,-0.451,-2.06724,-1.72,-1.56,73,85,-1.188,9,9,7,0.0362694300518134,"strand",-1.53333333333333,7.89,0.0004312203536006,58.3312262958281,1393450.9402217,Inf,23.547488635408,20,28,0,0,28,0,0,0,0,0,0,0,0,0,0,0,0,-5,0,0,-5,0,0,2,3,-0.848024316109423,-0.116537467700258,-0.397454433592248,-0.293265132139812,-0.408376963350785,0.768421052631579,-0.978583196046129,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","T:D",14.1472939191285,0.915018435774987,132.576060676241,0.106710773023171,4.17896182049081,NA,1.7659011066874,2.48532104922106e-05,4.60461750194108,5.71767556863798,Inf,1.21868387173808e-06,"lineage2","dr_mutations_pyrazinamide","ALA",0,"ERR1023501","ERR1023501","lineage2.2.1.1","","","pnca_p.asp49ala","A","E","ASP","DA49","pnca_complex.pdb"
|
|
"D49A","L3","PZA","D","D49",49,"A",1,"MDR","DM","hydrophilic","hydrophobic","acidic","non-polar","neg","non-polar",3.452,-3.348,-0.451,-2.06724,-1.72,-1.56,73,85,-1.188,9,9,7,0.0362694300518134,"strand",-1.53333333333333,7.89,0.0004312203536006,58.3312262958281,1393450.9402217,Inf,23.547488635408,20,28,0,0,28,0,0,0,0,0,0,0,0,0,0,0,0,-5,0,0,-5,0,0,2,3,-0.848024316109423,-0.116537467700258,-0.397454433592248,-0.293265132139812,-0.408376963350785,0.768421052631579,-0.978583196046129,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","T:D",14.1472939191285,0.915018435774987,132.576060676241,0.106710773023171,4.17896182049081,NA,1.7659011066874,2.48532104922106e-05,4.60461750194108,5.71767556863798,Inf,1.21868387173808e-06,"lineage3","dr_mutations_pyrazinamide","ALA",0,"ERR2517041","ERR2517041","lineage3","gb","UK","pnca_p.asp49ala","A","E","ASP","DA49","pnca_complex.pdb"
|
|
"D49A","L2","PZA","D","D49",49,"A",1,"MDR","DM","hydrophilic","hydrophobic","acidic","non-polar","neg","non-polar",3.452,-3.348,-0.451,-2.06724,-1.72,-1.56,73,85,-1.188,9,9,7,0.0362694300518134,"strand",-1.53333333333333,7.89,0.0004312203536006,58.3312262958281,1393450.9402217,Inf,23.547488635408,20,28,0,0,28,0,0,0,0,0,0,0,0,0,0,0,0,-5,0,0,-5,0,0,2,3,-0.848024316109423,-0.116537467700258,-0.397454433592248,-0.293265132139812,-0.408376963350785,0.768421052631579,-0.978583196046129,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","T:D",14.1472939191285,0.915018435774987,132.576060676241,0.106710773023171,4.17896182049081,NA,1.7659011066874,2.48532104922106e-05,4.60461750194108,5.71767556863798,Inf,1.21868387173808e-06,"lineage2","dr_mutations_pyrazinamide","ALA",0,"ERR2516935","ERR2516935","lineage2.2.1.2","gb","UK","pnca_p.asp49ala","A","E","ASP","DA49","pnca_complex.pdb"
|
|
"D49A","L2","PZA","D","D49",49,"A",NA,"MDR","DM","hydrophilic","hydrophobic","acidic","non-polar","neg","non-polar",3.452,-3.348,-0.451,-2.06724,-1.72,-1.56,73,85,-1.188,9,9,7,0.0362694300518134,"strand",-1.53333333333333,7.89,0.0004312203536006,58.3312262958281,1393450.9402217,Inf,23.547488635408,20,28,0,0,28,0,0,0,0,0,0,0,0,0,0,0,0,-5,0,0,-5,0,0,2,3,-0.848024316109423,-0.116537467700258,-0.397454433592248,-0.293265132139812,-0.408376963350785,0.768421052631579,-0.978583196046129,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","T:D",14.1472939191285,0.915018435774987,132.576060676241,0.106710773023171,4.17896182049081,NA,1.7659011066874,2.48532104922106e-05,4.60461750194108,5.71767556863798,Inf,1.21868387173808e-06,"lineage2","dr_mutations_pyrazinamide","ALA",0,"SRR671869,BGI_144","SRR671869","lineage2.2.1","cn","China","pnca_p.asp49ala","A","E","ASP","DA49","pnca_complex.pdb"
|
|
"D49A","L4","PZA","D","D49",49,"A",NA,"Pre-XDR","DM","hydrophilic","hydrophobic","acidic","non-polar","neg","non-polar",3.452,-3.348,-0.451,-2.06724,-1.72,-1.56,73,85,-1.188,9,9,7,0.0362694300518134,"strand",-1.53333333333333,7.89,0.0004312203536006,58.3312262958281,1393450.9402217,Inf,23.547488635408,20,28,0,0,28,0,0,0,0,0,0,0,0,0,0,0,0,-5,0,0,-5,0,0,2,3,-0.848024316109423,-0.116537467700258,-0.397454433592248,-0.293265132139812,-0.408376963350785,0.768421052631579,-0.978583196046129,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","T:D",14.1472939191285,0.915018435774987,132.576060676241,0.106710773023171,4.17896182049081,NA,1.7659011066874,2.48532104922106e-05,4.60461750194108,5.71767556863798,Inf,1.21868387173808e-06,"lineage4","dr_mutations_pyrazinamide","ALA",0,"SRR5818583","SRR5818583","lineage4.1.1.1","dj","Djibouti","pnca_p.asp49ala","A","E","ASP","DA49","pnca_complex.pdb"
|
|
"D49E","L4","PZA","D","D49",49,"E",NA,"MDR","DM","hydrophilic","hydrophilic","acidic","acidic","neg","neg",3.452,0.251,-0.472,-0.696543,-2.35,-0.28,75,85,-1.188,9,9,7,0.0362694300518134,"strand",-1.53333333333333,7.89,0.0002156101768003,9.70466975178797,9.70465898653052,9.70194990589383,2.29168245016684,-22,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-5,0,-1,-6,-10,0,-6,-8,0.112556053811659,-0.121963824289406,-0.133919672383296,-0.400682011935209,-0.0732984293193717,0.789473684210526,-0.978583196046129,"Stabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","T:D",2.27260607808817,0.0634455902260897,1.22442760158496,1.8560559033024,0.929172866365932,208.881603004782,0.986980761010679,0.0776844925942494,1.10966566656461,0.504888890842109,570.372842410328,0.130068862702538,"lineage4","dr_mutations_pyrazinamide","GLU",0,"ERR1555056","ERR1555056","lineage4.3.3","","","pnca_p.asp49glu","A","E","ASP","DA49","pnca_complex.pdb"
|
|
"D49E","L2","PZA","D","D49",49,"E",1,"MDR","DM","hydrophilic","hydrophilic","acidic","acidic","neg","neg",3.452,0.251,-0.472,-0.696543,-2.35,-0.28,75,85,-1.188,9,9,7,0.0362694300518134,"strand",-1.53333333333333,7.89,0.0002156101768003,9.70466975178797,9.70465898653052,9.70194990589383,2.29168245016684,-22,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-5,0,-1,-6,-10,0,-6,-8,0.112556053811659,-0.121963824289406,-0.133919672383296,-0.400682011935209,-0.0732984293193717,0.789473684210526,-0.978583196046129,"Stabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","T:D",2.27260607808817,0.0634455902260897,1.22442760158496,1.8560559033024,0.929172866365932,208.881603004782,0.986980761010679,0.0776844925942494,1.10966566656461,0.504888890842109,570.372842410328,0.130068862702538,"lineage2","dr_mutations_pyrazinamide","GLU",0,"MDR_15129","SRR6824427","lineage2.2.1","cn","China: Zhoucun District, Zibo City, Shandong Province","pnca_p.asp49glu","A","E","ASP","DA49","pnca_complex.pdb"
|
|
"D49E","L4","PZA","D","D49",49,"E",1,"MDR","DM","hydrophilic","hydrophilic","acidic","acidic","neg","neg",3.452,0.251,-0.472,-0.696543,-2.35,-0.28,75,85,-1.188,9,9,7,0.0362694300518134,"strand",-1.53333333333333,7.89,0.0002156101768003,9.70466975178797,9.70465898653052,9.70194990589383,2.29168245016684,-22,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-5,0,-1,-6,-10,0,-6,-8,0.112556053811659,-0.121963824289406,-0.133919672383296,-0.400682011935209,-0.0732984293193717,0.789473684210526,-0.978583196046129,"Stabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","T:D",2.27260607808817,0.0634455902260897,1.22442760158496,1.8560559033024,0.929172866365932,208.881603004782,0.986980761010679,0.0776844925942494,1.10966566656461,0.504888890842109,570.372842410328,0.130068862702538,"lineage4","dr_mutations_pyrazinamide","GLU",0,"ERR2516417","ERR2516417","lineage4.3.4.2.1","nl","Netherlands","pnca_p.asp49glu","A","E","ASP","DA49","pnca_complex.pdb"
|
|
"D49E","L2","PZA","D","D49",49,"E",0,"Pre-MDR","DM","hydrophilic","hydrophilic","acidic","acidic","neg","neg",3.452,0.251,-0.472,-0.696543,-2.35,-0.28,75,85,-1.188,9,9,7,0.0362694300518134,"strand",-1.53333333333333,7.89,0.0002156101768003,9.70466975178797,9.70465898653052,9.70194990589383,2.29168245016684,-22,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-5,0,-1,-6,-10,0,-6,-8,0.112556053811659,-0.121963824289406,-0.133919672383296,-0.400682011935209,-0.0732984293193717,0.789473684210526,-0.978583196046129,"Stabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","T:D",2.27260607808817,0.0634455902260897,1.22442760158496,1.8560559033024,0.929172866365932,208.881603004782,0.986980761010679,0.0776844925942494,1.10966566656461,0.504888890842109,570.372842410328,0.130068862702538,"lineage2","dr_mutations_pyrazinamide","GLU",0,"MDR_3364","SRR6824606","lineage2.2.1","cn","China: Zhangbei County, Zhangjiakou City, Hebei Province","pnca_p.asp49glu","A","E","ASP","DA49","pnca_complex.pdb"
|
|
"D49E","L4","PZA","D","D49",49,"E",NA,"MDR","DM","hydrophilic","hydrophilic","acidic","acidic","neg","neg",3.452,0.251,-0.472,-0.696543,-2.35,-0.28,75,85,-1.188,9,9,7,0.0362694300518134,"strand",-1.53333333333333,7.89,0.0002156101768003,9.70466975178797,9.70465898653052,9.70194990589383,2.29168245016684,-22,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-5,0,-1,-6,-10,0,-6,-8,0.112556053811659,-0.121963824289406,-0.133919672383296,-0.400682011935209,-0.0732984293193717,0.789473684210526,-0.978583196046129,"Stabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","T:D",2.27260607808817,0.0634455902260897,1.22442760158496,1.8560559033024,0.929172866365932,208.881603004782,0.986980761010679,0.0776844925942494,1.10966566656461,0.504888890842109,570.372842410328,0.130068862702538,"lineage4","dr_mutations_pyrazinamide","GLU",0,"ERR1555049","ERR1555049","lineage4.3.3","","","pnca_p.asp49glu","A","E","ASP","DA49","pnca_complex.pdb"
|
|
"D49E","L4","PZA","D","D49",49,"E",NA,"Pre-MDR","DM","hydrophilic","hydrophilic","acidic","acidic","neg","neg",3.452,0.251,-0.472,-0.696543,-2.35,-0.28,75,85,-1.188,9,9,7,0.0362694300518134,"strand",-1.53333333333333,7.89,0.0002156101768003,9.70466975178797,9.70465898653052,9.70194990589383,2.29168245016684,-22,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-5,0,-1,-6,-10,0,-6,-8,0.112556053811659,-0.121963824289406,-0.133919672383296,-0.400682011935209,-0.0732984293193717,0.789473684210526,-0.978583196046129,"Stabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","T:D",2.27260607808817,0.0634455902260897,1.22442760158496,1.8560559033024,0.929172866365932,208.881603004782,0.986980761010679,0.0776844925942494,1.10966566656461,0.504888890842109,570.372842410328,0.130068862702538,"lineage4","dr_mutations_pyrazinamide","GLU",0,"ERR1035206","ERR1035206","lineage4.8","pt","Portugal","pnca_p.asp49glu","A","E","ASP","DA49","pnca_complex.pdb"
|
|
"D49E","L2","PZA","D","D49",49,"E",NA,"Pre-MDR","DM","hydrophilic","hydrophilic","acidic","acidic","neg","neg",3.452,0.251,-0.472,-0.696543,-2.35,-0.28,75,85,-1.188,9,9,7,0.0362694300518134,"strand",-1.53333333333333,7.89,0.0002156101768003,9.70466975178797,9.70465898653052,9.70194990589383,2.29168245016684,-22,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-5,0,-1,-6,-10,0,-6,-8,0.112556053811659,-0.121963824289406,-0.133919672383296,-0.400682011935209,-0.0732984293193717,0.789473684210526,-0.978583196046129,"Stabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","T:D",2.27260607808817,0.0634455902260897,1.22442760158496,1.8560559033024,0.929172866365932,208.881603004782,0.986980761010679,0.0776844925942494,1.10966566656461,0.504888890842109,570.372842410328,0.130068862702538,"lineage2","dr_mutations_pyrazinamide","GLU",0,"SRS797073","SRR1723577","lineage2.2.1","cn","China:Hebei","pnca_p.asp49glu","A","E","ASP","DA49","pnca_complex.pdb"
|
|
"D49E","L4","PZA","D","D49",49,"E",NA,"Pre-XDR","DM","hydrophilic","hydrophilic","acidic","acidic","neg","neg",3.452,0.251,-0.472,-0.696543,-2.35,-0.28,75,85,-1.188,9,9,7,0.0362694300518134,"strand",-1.53333333333333,7.89,0.0002156101768003,9.70466975178797,9.70465898653052,9.70194990589383,2.29168245016684,-22,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-5,0,-1,-6,-10,0,-6,-8,0.112556053811659,-0.121963824289406,-0.133919672383296,-0.400682011935209,-0.0732984293193717,0.789473684210526,-0.978583196046129,"Stabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","T:D",2.27260607808817,0.0634455902260897,1.22442760158496,1.8560559033024,0.929172866365932,208.881603004782,0.986980761010679,0.0776844925942494,1.10966566656461,0.504888890842109,570.372842410328,0.130068862702538,"lineage4","dr_mutations_pyrazinamide","GLU",0,"ERR1193782","ERR1193782","lineage4.3.3","pt","Portugal","pnca_p.asp49glu","A","E","ASP","DA49","pnca_complex.pdb"
|
|
"D49E","L4","PZA","D","D49",49,"E",NA,"MDR","DM","hydrophilic","hydrophilic","acidic","acidic","neg","neg",3.452,0.251,-0.472,-0.696543,-2.35,-0.28,75,85,-1.188,9,9,7,0.0362694300518134,"strand",-1.53333333333333,7.89,0.0002156101768003,9.70466975178797,9.70465898653052,9.70194990589383,2.29168245016684,-22,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-5,0,-1,-6,-10,0,-6,-8,0.112556053811659,-0.121963824289406,-0.133919672383296,-0.400682011935209,-0.0732984293193717,0.789473684210526,-0.978583196046129,"Stabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","T:D",2.27260607808817,0.0634455902260897,1.22442760158496,1.8560559033024,0.929172866365932,208.881603004782,0.986980761010679,0.0776844925942494,1.10966566656461,0.504888890842109,570.372842410328,0.130068862702538,"lineage4","dr_mutations_pyrazinamide","GLU",0,"ERR1035343","ERR1035343","lineage4.3.3","br","Brazil","pnca_p.asp49glu","A","E","ASP","DA49","pnca_complex.pdb"
|
|
"D49G","L4","PZA","D","D49",49,"G",1,"XDR","DM","hydrophilic","hydrophobic","acidic","neutral","neg","non-polar",3.452,-3.463,-1.157,0.460983,-2.415,-1.08,83,91,-1.188,9,9,7,0.0362694300518134,"strand",-1.53333333333333,7.89,0.0005030904125341,29.1630847029077,29.1630732435189,29.1293325978315,18.6717493808583,28,30,0,0,30,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-1,6,0,9,19,-0.877152988855116,-0.298966408268734,0.0167900042978169,-0.411764705882353,-0.282722513089005,0.873684210526316,-0.978583196046129,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","T:D",3.37290329402599,0.0017890770828182,1.07995768762032,3.12318096596744,4.97876379054023,550.894323518622,1.46483345924118,0.0001485295621003,3.828187099348,3.53443753556636,1331.56873199938,1.55265977742841e-05,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR2516206","ERR2516206","lineage4.3.3","be","Belgium","pnca_p.asp49gly","A","E","ASP","DA49","pnca_complex.pdb"
|
|
"D49G","L4","PZA","D","D49",49,"G",NA,"XDR","DM","hydrophilic","hydrophobic","acidic","neutral","neg","non-polar",3.452,-3.463,-1.157,0.460983,-2.415,-1.08,83,91,-1.188,9,9,7,0.0362694300518134,"strand",-1.53333333333333,7.89,0.0005030904125341,29.1630847029077,29.1630732435189,29.1293325978315,18.6717493808583,28,30,0,0,30,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-1,6,0,9,19,-0.877152988855116,-0.298966408268734,0.0167900042978169,-0.411764705882353,-0.282722513089005,0.873684210526316,-0.978583196046129,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","T:D",3.37290329402599,0.0017890770828182,1.07995768762032,3.12318096596744,4.97876379054023,550.894323518622,1.46483345924118,0.0001485295621003,3.828187099348,3.53443753556636,1331.56873199938,1.55265977742841e-05,"lineage4","dr_mutations_pyrazinamide","GLY",0,"SAMN02419672,XTB13-247","SRR1174863_SRR1169228_SRR1163315_SRR1163115","lineage4.3.3","by","Belarus","pnca_p.asp49gly","A","E","ASP","DA49","pnca_complex.pdb"
|
|
"D49G","L4","PZA","D","D49",49,"G",NA,"XDR","DM","hydrophilic","hydrophobic","acidic","neutral","neg","non-polar",3.452,-3.463,-1.157,0.460983,-2.415,-1.08,83,91,-1.188,9,9,7,0.0362694300518134,"strand",-1.53333333333333,7.89,0.0005030904125341,29.1630847029077,29.1630732435189,29.1293325978315,18.6717493808583,28,30,0,0,30,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-1,6,0,9,19,-0.877152988855116,-0.298966408268734,0.0167900042978169,-0.411764705882353,-0.282722513089005,0.873684210526316,-0.978583196046129,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","T:D",3.37290329402599,0.0017890770828182,1.07995768762032,3.12318096596744,4.97876379054023,550.894323518622,1.46483345924118,0.0001485295621003,3.828187099348,3.53443753556636,1331.56873199938,1.55265977742841e-05,"lineage4","dr_mutations_pyrazinamide","GLY",0,"SAMN02419555","SRR1159377_SRR1181300_SRR1181071_SRR1159129","lineage4.3.3","by","Belarus","pnca_p.asp49gly","A","E","ASP","DA49","pnca_complex.pdb"
|
|
"D49G","L4","PZA","D","D49",49,"G",NA,"Pre-XDR","DM","hydrophilic","hydrophobic","acidic","neutral","neg","non-polar",3.452,-3.463,-1.157,0.460983,-2.415,-1.08,83,91,-1.188,9,9,7,0.0362694300518134,"strand",-1.53333333333333,7.89,0.0005030904125341,29.1630847029077,29.1630732435189,29.1293325978315,18.6717493808583,28,30,0,0,30,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-1,6,0,9,19,-0.877152988855116,-0.298966408268734,0.0167900042978169,-0.411764705882353,-0.282722513089005,0.873684210526316,-0.978583196046129,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","T:D",3.37290329402599,0.0017890770828182,1.07995768762032,3.12318096596744,4.97876379054023,550.894323518622,1.46483345924118,0.0001485295621003,3.828187099348,3.53443753556636,1331.56873199938,1.55265977742841e-05,"lineage4","dr_mutations_pyrazinamide","GLY",0,"SAMN02419653","SRR1163379_SRR1163137_SRR1172129_SRR1168985","lineage4.3.3","by","Belarus","pnca_p.asp49gly","A","E","ASP","DA49","pnca_complex.pdb"
|
|
"D49G","L4","PZA","D","D49",49,"G",NA,"XDR","DM","hydrophilic","hydrophobic","acidic","neutral","neg","non-polar",3.452,-3.463,-1.157,0.460983,-2.415,-1.08,83,91,-1.188,9,9,7,0.0362694300518134,"strand",-1.53333333333333,7.89,0.0005030904125341,29.1630847029077,29.1630732435189,29.1293325978315,18.6717493808583,28,30,0,0,30,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-1,6,0,9,19,-0.877152988855116,-0.298966408268734,0.0167900042978169,-0.411764705882353,-0.282722513089005,0.873684210526316,-0.978583196046129,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","T:D",3.37290329402599,0.0017890770828182,1.07995768762032,3.12318096596744,4.97876379054023,550.894323518622,1.46483345924118,0.0001485295621003,3.828187099348,3.53443753556636,1331.56873199938,1.55265977742841e-05,"lineage4","dr_mutations_pyrazinamide","GLY",0,"SAMN02419563","SRR1181098_SRR1159810_SRR1159747_SRR1180921","lineage4.3.3","by","Belarus","pnca_p.asp49gly","A","E","ASP","DA49","pnca_complex.pdb"
|
|
"D49G","L2","PZA","D","D49",49,"G",NA,"XDR","DM","hydrophilic","hydrophobic","acidic","neutral","neg","non-polar",3.452,-3.463,-1.157,0.460983,-2.415,-1.08,83,91,-1.188,9,9,7,0.0362694300518134,"strand",-1.53333333333333,7.89,0.0005030904125341,29.1630847029077,29.1630732435189,29.1293325978315,18.6717493808583,28,30,0,0,30,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-1,6,0,9,19,-0.877152988855116,-0.298966408268734,0.0167900042978169,-0.411764705882353,-0.282722513089005,0.873684210526316,-0.978583196046129,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","T:D",3.37290329402599,0.0017890770828182,1.07995768762032,3.12318096596744,4.97876379054023,550.894323518622,1.46483345924118,0.0001485295621003,3.828187099348,3.53443753556636,1331.56873199938,1.55265977742841e-05,"lineage2","dr_mutations_pyrazinamide","GLY",0,"SAMN07236513,SRR5709932","SRR5709932","lineage2.2.1","th","Thailand","pnca_p.asp49gly","A","E","ASP","DA49","pnca_complex.pdb"
|
|
"D49G","L4","PZA","D","D49",49,"G",NA,"Pre-XDR","DM","hydrophilic","hydrophobic","acidic","neutral","neg","non-polar",3.452,-3.463,-1.157,0.460983,-2.415,-1.08,83,91,-1.188,9,9,7,0.0362694300518134,"strand",-1.53333333333333,7.89,0.0005030904125341,29.1630847029077,29.1630732435189,29.1293325978315,18.6717493808583,28,30,0,0,30,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-1,6,0,9,19,-0.877152988855116,-0.298966408268734,0.0167900042978169,-0.411764705882353,-0.282722513089005,0.873684210526316,-0.978583196046129,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","T:D",3.37290329402599,0.0017890770828182,1.07995768762032,3.12318096596744,4.97876379054023,550.894323518622,1.46483345924118,0.0001485295621003,3.828187099348,3.53443753556636,1331.56873199938,1.55265977742841e-05,"lineage4","dr_mutations_pyrazinamide","GLY",0,"SAMN02419647","SRR1174858_SRR1169141_SRR1163319_SRR1163203","lineage4.3.3","by","Belarus","pnca_p.asp49gly","A","E","ASP","DA49","pnca_complex.pdb"
|
|
"D49G","L4","PZA","D","D49",49,"G",NA,"XDR","DM","hydrophilic","hydrophobic","acidic","neutral","neg","non-polar",3.452,-3.463,-1.157,0.460983,-2.415,-1.08,83,91,-1.188,9,9,7,0.0362694300518134,"strand",-1.53333333333333,7.89,0.0005030904125341,29.1630847029077,29.1630732435189,29.1293325978315,18.6717493808583,28,30,0,0,30,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-1,6,0,9,19,-0.877152988855116,-0.298966408268734,0.0167900042978169,-0.411764705882353,-0.282722513089005,0.873684210526316,-0.978583196046129,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","T:D",3.37290329402599,0.0017890770828182,1.07995768762032,3.12318096596744,4.97876379054023,550.894323518622,1.46483345924118,0.0001485295621003,3.828187099348,3.53443753556636,1331.56873199938,1.55265977742841e-05,"lineage4","dr_mutations_pyrazinamide","GLY",0,"SAMN02419549","SRR1183963_SRR1159252_SRR1162540_SRR1180995","lineage4.3.3","by","Belarus","pnca_p.asp49gly","A","E","ASP","DA49","pnca_complex.pdb"
|
|
"D49G","L4","PZA","D","D49",49,"G",NA,"Pre-XDR","DM","hydrophilic","hydrophobic","acidic","neutral","neg","non-polar",3.452,-3.463,-1.157,0.460983,-2.415,-1.08,83,91,-1.188,9,9,7,0.0362694300518134,"strand",-1.53333333333333,7.89,0.0005030904125341,29.1630847029077,29.1630732435189,29.1293325978315,18.6717493808583,28,30,0,0,30,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-1,6,0,9,19,-0.877152988855116,-0.298966408268734,0.0167900042978169,-0.411764705882353,-0.282722513089005,0.873684210526316,-0.978583196046129,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","T:D",3.37290329402599,0.0017890770828182,1.07995768762032,3.12318096596744,4.97876379054023,550.894323518622,1.46483345924118,0.0001485295621003,3.828187099348,3.53443753556636,1331.56873199938,1.55265977742841e-05,"lineage4","dr_mutations_pyrazinamide","GLY",0,"SRR2993039","SRR2993039","lineage4.3.3","ru","Russia","pnca_p.asp49gly","A","E","ASP","DA49","pnca_complex.pdb"
|
|
"D49G","L3","PZA","D","D49",49,"G",1,"MDR","DM","hydrophilic","hydrophobic","acidic","neutral","neg","non-polar",3.452,-3.463,-1.157,0.460983,-2.415,-1.08,83,91,-1.188,9,9,7,0.0362694300518134,"strand",-1.53333333333333,7.89,0.0005030904125341,29.1630847029077,29.1630732435189,29.1293325978315,18.6717493808583,28,30,0,0,30,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-1,6,0,9,19,-0.877152988855116,-0.298966408268734,0.0167900042978169,-0.411764705882353,-0.282722513089005,0.873684210526316,-0.978583196046129,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","T:D",3.37290329402599,0.0017890770828182,1.07995768762032,3.12318096596744,4.97876379054023,550.894323518622,1.46483345924118,0.0001485295621003,3.828187099348,3.53443753556636,1331.56873199938,1.55265977742841e-05,"lineage3","dr_mutations_pyrazinamide","GLY",0,"ERR2510271","ERR2510271","lineage3","pk","Pakistan","pnca_p.asp49gly","A","E","ASP","DA49","pnca_complex.pdb"
|
|
"D49G","L4","PZA","D","D49",49,"G",NA,"XDR","DM","hydrophilic","hydrophobic","acidic","neutral","neg","non-polar",3.452,-3.463,-1.157,0.460983,-2.415,-1.08,83,91,-1.188,9,9,7,0.0362694300518134,"strand",-1.53333333333333,7.89,0.0005030904125341,29.1630847029077,29.1630732435189,29.1293325978315,18.6717493808583,28,30,0,0,30,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-1,6,0,9,19,-0.877152988855116,-0.298966408268734,0.0167900042978169,-0.411764705882353,-0.282722513089005,0.873684210526316,-0.978583196046129,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","T:D",3.37290329402599,0.0017890770828182,1.07995768762032,3.12318096596744,4.97876379054023,550.894323518622,1.46483345924118,0.0001485295621003,3.828187099348,3.53443753556636,1331.56873199938,1.55265977742841e-05,"lineage4","dr_mutations_pyrazinamide","GLY",0,"SAMN02419624","SRR1169039_SRR1163001_SRR1163363_SRR1172044","lineage4.3.3","by","Belarus","pnca_p.asp49gly","A","E","ASP","DA49","pnca_complex.pdb"
|
|
"D49G","L4","PZA","D","D49",49,"G",1,"Pre-XDR","DM","hydrophilic","hydrophobic","acidic","neutral","neg","non-polar",3.452,-3.463,-1.157,0.460983,-2.415,-1.08,83,91,-1.188,9,9,7,0.0362694300518134,"strand",-1.53333333333333,7.89,0.0005030904125341,29.1630847029077,29.1630732435189,29.1293325978315,18.6717493808583,28,30,0,0,30,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-1,6,0,9,19,-0.877152988855116,-0.298966408268734,0.0167900042978169,-0.411764705882353,-0.282722513089005,0.873684210526316,-0.978583196046129,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","T:D",3.37290329402599,0.0017890770828182,1.07995768762032,3.12318096596744,4.97876379054023,550.894323518622,1.46483345924118,0.0001485295621003,3.828187099348,3.53443753556636,1331.56873199938,1.55265977742841e-05,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR228036,2314R-sc-2012-10-11T13:38:23Z-1494200","ERR228036","lineage4.3.3","ru","Russia,Samara","pnca_p.asp49gly","A","E","ASP","DA49","pnca_complex.pdb"
|
|
"D49G","L4","PZA","D","D49",49,"G",NA,"Pre-XDR","DM","hydrophilic","hydrophobic","acidic","neutral","neg","non-polar",3.452,-3.463,-1.157,0.460983,-2.415,-1.08,83,91,-1.188,9,9,7,0.0362694300518134,"strand",-1.53333333333333,7.89,0.0005030904125341,29.1630847029077,29.1630732435189,29.1293325978315,18.6717493808583,28,30,0,0,30,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-1,6,0,9,19,-0.877152988855116,-0.298966408268734,0.0167900042978169,-0.411764705882353,-0.282722513089005,0.873684210526316,-0.978583196046129,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","T:D",3.37290329402599,0.0017890770828182,1.07995768762032,3.12318096596744,4.97876379054023,550.894323518622,1.46483345924118,0.0001485295621003,3.828187099348,3.53443753556636,1331.56873199938,1.55265977742841e-05,"lineage4","dr_mutations_pyrazinamide","GLY",0,"SAMN02058519","SRR924711_SRR958480","lineage4.3.3","by","Belarus","pnca_p.asp49gly","A","E","ASP","DA49","pnca_complex.pdb"
|
|
"D49G","L4","PZA","D","D49",49,"G",NA,"XDR","DM","hydrophilic","hydrophobic","acidic","neutral","neg","non-polar",3.452,-3.463,-1.157,0.460983,-2.415,-1.08,83,91,-1.188,9,9,7,0.0362694300518134,"strand",-1.53333333333333,7.89,0.0005030904125341,29.1630847029077,29.1630732435189,29.1293325978315,18.6717493808583,28,30,0,0,30,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-1,6,0,9,19,-0.877152988855116,-0.298966408268734,0.0167900042978169,-0.411764705882353,-0.282722513089005,0.873684210526316,-0.978583196046129,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","T:D",3.37290329402599,0.0017890770828182,1.07995768762032,3.12318096596744,4.97876379054023,550.894323518622,1.46483345924118,0.0001485295621003,3.828187099348,3.53443753556636,1331.56873199938,1.55265977742841e-05,"lineage4","dr_mutations_pyrazinamide","GLY",0,"SAMN02419661","SRR1163341_SRR1168987_SRR1172299_SRR1163140","lineage4.3.3","by","Belarus","pnca_p.asp49gly","A","E","ASP","DA49","pnca_complex.pdb"
|
|
"D49G","L4","PZA","D","D49",49,"G",NA,"Pre-XDR","DM","hydrophilic","hydrophobic","acidic","neutral","neg","non-polar",3.452,-3.463,-1.157,0.460983,-2.415,-1.08,83,91,-1.188,9,9,7,0.0362694300518134,"strand",-1.53333333333333,7.89,0.0005030904125341,29.1630847029077,29.1630732435189,29.1293325978315,18.6717493808583,28,30,0,0,30,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-1,6,0,9,19,-0.877152988855116,-0.298966408268734,0.0167900042978169,-0.411764705882353,-0.282722513089005,0.873684210526316,-0.978583196046129,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","T:D",3.37290329402599,0.0017890770828182,1.07995768762032,3.12318096596744,4.97876379054023,550.894323518622,1.46483345924118,0.0001485295621003,3.828187099348,3.53443753556636,1331.56873199938,1.55265977742841e-05,"lineage4","dr_mutations_pyrazinamide","GLY",0,"SRR2993037","SRR2993037","lineage4.3.3","ru","Russia","pnca_p.asp49gly","A","E","ASP","DA49","pnca_complex.pdb"
|
|
"D49G","L4","PZA","D","D49",49,"G",NA,"Pre-XDR","DM","hydrophilic","hydrophobic","acidic","neutral","neg","non-polar",3.452,-3.463,-1.157,0.460983,-2.415,-1.08,83,91,-1.188,9,9,7,0.0362694300518134,"strand",-1.53333333333333,7.89,0.0005030904125341,29.1630847029077,29.1630732435189,29.1293325978315,18.6717493808583,28,30,0,0,30,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-1,6,0,9,19,-0.877152988855116,-0.298966408268734,0.0167900042978169,-0.411764705882353,-0.282722513089005,0.873684210526316,-0.978583196046129,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","T:D",3.37290329402599,0.0017890770828182,1.07995768762032,3.12318096596744,4.97876379054023,550.894323518622,1.46483345924118,0.0001485295621003,3.828187099348,3.53443753556636,1331.56873199938,1.55265977742841e-05,"lineage4","dr_mutations_pyrazinamide","GLY",0,"SAMN02419618","SRR1169127_SRR1163296_SRR1163194_SRR1172251","lineage4.3.3","by","Belarus","pnca_p.asp49gly","A","E","ASP","DA49","pnca_complex.pdb"
|
|
"D49G","L4","PZA","D","D49",49,"G",NA,"XDR","DM","hydrophilic","hydrophobic","acidic","neutral","neg","non-polar",3.452,-3.463,-1.157,0.460983,-2.415,-1.08,83,91,-1.188,9,9,7,0.0362694300518134,"strand",-1.53333333333333,7.89,0.0005030904125341,29.1630847029077,29.1630732435189,29.1293325978315,18.6717493808583,28,30,0,0,30,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-1,6,0,9,19,-0.877152988855116,-0.298966408268734,0.0167900042978169,-0.411764705882353,-0.282722513089005,0.873684210526316,-0.978583196046129,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","T:D",3.37290329402599,0.0017890770828182,1.07995768762032,3.12318096596744,4.97876379054023,550.894323518622,1.46483345924118,0.0001485295621003,3.828187099348,3.53443753556636,1331.56873199938,1.55265977742841e-05,"lineage4","dr_mutations_pyrazinamide","GLY",0,"SAMN07659388","SRR6046680","lineage4.3.3","gb","UK","pnca_p.asp49gly","A","E","ASP","DA49","pnca_complex.pdb"
|
|
"D49G","L4","PZA","D","D49",49,"G",0,"XDR","DM","hydrophilic","hydrophobic","acidic","neutral","neg","non-polar",3.452,-3.463,-1.157,0.460983,-2.415,-1.08,83,91,-1.188,9,9,7,0.0362694300518134,"strand",-1.53333333333333,7.89,0.0005030904125341,29.1630847029077,29.1630732435189,29.1293325978315,18.6717493808583,28,30,0,0,30,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-1,6,0,9,19,-0.877152988855116,-0.298966408268734,0.0167900042978169,-0.411764705882353,-0.282722513089005,0.873684210526316,-0.978583196046129,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","T:D",3.37290329402599,0.0017890770828182,1.07995768762032,3.12318096596744,4.97876379054023,550.894323518622,1.46483345924118,0.0001485295621003,3.828187099348,3.53443753556636,1331.56873199938,1.55265977742841e-05,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR2516964","ERR2516964","lineage4.3.3","gb","UK","pnca_p.asp49gly","A","E","ASP","DA49","pnca_complex.pdb"
|
|
"D49G","L4","PZA","D","D49",49,"G",NA,"Pre-XDR","DM","hydrophilic","hydrophobic","acidic","neutral","neg","non-polar",3.452,-3.463,-1.157,0.460983,-2.415,-1.08,83,91,-1.188,9,9,7,0.0362694300518134,"strand",-1.53333333333333,7.89,0.0005030904125341,29.1630847029077,29.1630732435189,29.1293325978315,18.6717493808583,28,30,0,0,30,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-1,6,0,9,19,-0.877152988855116,-0.298966408268734,0.0167900042978169,-0.411764705882353,-0.282722513089005,0.873684210526316,-0.978583196046129,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","T:D",3.37290329402599,0.0017890770828182,1.07995768762032,3.12318096596744,4.97876379054023,550.894323518622,1.46483345924118,0.0001485295621003,3.828187099348,3.53443753556636,1331.56873199938,1.55265977742841e-05,"lineage4","dr_mutations_pyrazinamide","GLY",0,"SAMN02419669","SRR1166908_SRR1162961_SRR1169122_SRR1172424","lineage4.3.3","by","Belarus","pnca_p.asp49gly","A","E","ASP","DA49","pnca_complex.pdb"
|
|
"D49G","L4","PZA","D","D49",49,"G",NA,"XDR","DM","hydrophilic","hydrophobic","acidic","neutral","neg","non-polar",3.452,-3.463,-1.157,0.460983,-2.415,-1.08,83,91,-1.188,9,9,7,0.0362694300518134,"strand",-1.53333333333333,7.89,0.0005030904125341,29.1630847029077,29.1630732435189,29.1293325978315,18.6717493808583,28,30,0,0,30,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-1,6,0,9,19,-0.877152988855116,-0.298966408268734,0.0167900042978169,-0.411764705882353,-0.282722513089005,0.873684210526316,-0.978583196046129,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","T:D",3.37290329402599,0.0017890770828182,1.07995768762032,3.12318096596744,4.97876379054023,550.894323518622,1.46483345924118,0.0001485295621003,3.828187099348,3.53443753556636,1331.56873199938,1.55265977742841e-05,"lineage4","dr_mutations_pyrazinamide","GLY",0,"SAMN02419600","SRR1159006_SRR1159308_SRR1181033_SRR1180938","lineage4.3.3","by","Belarus","pnca_p.asp49gly","A","E","ASP","DA49","pnca_complex.pdb"
|
|
"D49G","L4","PZA","D","D49",49,"G",NA,"XDR","DM","hydrophilic","hydrophobic","acidic","neutral","neg","non-polar",3.452,-3.463,-1.157,0.460983,-2.415,-1.08,83,91,-1.188,9,9,7,0.0362694300518134,"strand",-1.53333333333333,7.89,0.0005030904125341,29.1630847029077,29.1630732435189,29.1293325978315,18.6717493808583,28,30,0,0,30,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-1,6,0,9,19,-0.877152988855116,-0.298966408268734,0.0167900042978169,-0.411764705882353,-0.282722513089005,0.873684210526316,-0.978583196046129,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","T:D",3.37290329402599,0.0017890770828182,1.07995768762032,3.12318096596744,4.97876379054023,550.894323518622,1.46483345924118,0.0001485295621003,3.828187099348,3.53443753556636,1331.56873199938,1.55265977742841e-05,"lineage4","dr_mutations_pyrazinamide","GLY",0,"SAMN02419572","SRR1162537_SRR1180950_SRR1181131_SRR1159290","lineage4.3.3","by","Belarus","pnca_p.asp49gly","A","E","ASP","DA49","pnca_complex.pdb"
|
|
"D49G","L4","PZA","D","D49",49,"G",NA,"XDR","DM","hydrophilic","hydrophobic","acidic","neutral","neg","non-polar",3.452,-3.463,-1.157,0.460983,-2.415,-1.08,83,91,-1.188,9,9,7,0.0362694300518134,"strand",-1.53333333333333,7.89,0.0005030904125341,29.1630847029077,29.1630732435189,29.1293325978315,18.6717493808583,28,30,0,0,30,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-1,6,0,9,19,-0.877152988855116,-0.298966408268734,0.0167900042978169,-0.411764705882353,-0.282722513089005,0.873684210526316,-0.978583196046129,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","T:D",3.37290329402599,0.0017890770828182,1.07995768762032,3.12318096596744,4.97876379054023,550.894323518622,1.46483345924118,0.0001485295621003,3.828187099348,3.53443753556636,1331.56873199938,1.55265977742841e-05,"lineage4","dr_mutations_pyrazinamide","GLY",0,"SAMN02419645","SRR1169103_SRR1172162_SRR1163337_SRR1163089","lineage4.3.3","by","Belarus","pnca_p.asp49gly","A","E","ASP","DA49","pnca_complex.pdb"
|
|
"D49G","L4","PZA","D","D49",49,"G",NA,"XDR","DM","hydrophilic","hydrophobic","acidic","neutral","neg","non-polar",3.452,-3.463,-1.157,0.460983,-2.415,-1.08,83,91,-1.188,9,9,7,0.0362694300518134,"strand",-1.53333333333333,7.89,0.0005030904125341,29.1630847029077,29.1630732435189,29.1293325978315,18.6717493808583,28,30,0,0,30,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-1,6,0,9,19,-0.877152988855116,-0.298966408268734,0.0167900042978169,-0.411764705882353,-0.282722513089005,0.873684210526316,-0.978583196046129,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","T:D",3.37290329402599,0.0017890770828182,1.07995768762032,3.12318096596744,4.97876379054023,550.894323518622,1.46483345924118,0.0001485295621003,3.828187099348,3.53443753556636,1331.56873199938,1.55265977742841e-05,"lineage4","dr_mutations_pyrazinamide","GLY",0,"SAMN02419654","SRR1169014_SRR1163106_SRR1172130_SRR1163338","lineage4.3.3","by","Belarus","pnca_p.asp49gly","A","E","ASP","DA49","pnca_complex.pdb"
|
|
"D49G","L4","PZA","D","D49",49,"G",1,"Pre-XDR","DM","hydrophilic","hydrophobic","acidic","neutral","neg","non-polar",3.452,-3.463,-1.157,0.460983,-2.415,-1.08,83,91,-1.188,9,9,7,0.0362694300518134,"strand",-1.53333333333333,7.89,0.0005030904125341,29.1630847029077,29.1630732435189,29.1293325978315,18.6717493808583,28,30,0,0,30,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-1,6,0,9,19,-0.877152988855116,-0.298966408268734,0.0167900042978169,-0.411764705882353,-0.282722513089005,0.873684210526316,-0.978583196046129,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","T:D",3.37290329402599,0.0017890770828182,1.07995768762032,3.12318096596744,4.97876379054023,550.894323518622,1.46483345924118,0.0001485295621003,3.828187099348,3.53443753556636,1331.56873199938,1.55265977742841e-05,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR2864247","ERR2864247","lineage4.3.3","pt","Portugal","pnca_p.asp49gly","A","E","ASP","DA49","pnca_complex.pdb"
|
|
"D49G","L4","PZA","D","D49",49,"G",NA,"XDR","DM","hydrophilic","hydrophobic","acidic","neutral","neg","non-polar",3.452,-3.463,-1.157,0.460983,-2.415,-1.08,83,91,-1.188,9,9,7,0.0362694300518134,"strand",-1.53333333333333,7.89,0.0005030904125341,29.1630847029077,29.1630732435189,29.1293325978315,18.6717493808583,28,30,0,0,30,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-1,6,0,9,19,-0.877152988855116,-0.298966408268734,0.0167900042978169,-0.411764705882353,-0.282722513089005,0.873684210526316,-0.978583196046129,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","T:D",3.37290329402599,0.0017890770828182,1.07995768762032,3.12318096596744,4.97876379054023,550.894323518622,1.46483345924118,0.0001485295621003,3.828187099348,3.53443753556636,1331.56873199938,1.55265977742841e-05,"lineage4","dr_mutations_pyrazinamide","GLY",0,"SAMN02419626","SRR1174825_SRR1168959_SRR1162996_SRR1163385","lineage4.3.3","by","Belarus","pnca_p.asp49gly","A","E","ASP","DA49","pnca_complex.pdb"
|
|
"D49G","L2","PZA","D","D49",49,"G",NA,"Pre-XDR","DM","hydrophilic","hydrophobic","acidic","neutral","neg","non-polar",3.452,-3.463,-1.157,0.460983,-2.415,-1.08,83,91,-1.188,9,9,7,0.0362694300518134,"strand",-1.53333333333333,7.89,0.0005030904125341,29.1630847029077,29.1630732435189,29.1293325978315,18.6717493808583,28,30,0,0,30,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-1,6,0,9,19,-0.877152988855116,-0.298966408268734,0.0167900042978169,-0.411764705882353,-0.282722513089005,0.873684210526316,-0.978583196046129,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","T:D",3.37290329402599,0.0017890770828182,1.07995768762032,3.12318096596744,4.97876379054023,550.894323518622,1.46483345924118,0.0001485295621003,3.828187099348,3.53443753556636,1331.56873199938,1.55265977742841e-05,"lineage2","dr_mutations_pyrazinamide","GLY",0,"SRR5709801,SAMN07236267","SRR5709801","lineage2.2.1","th","Thailand","pnca_p.asp49gly","A","E","ASP","DA49","pnca_complex.pdb"
|
|
"D49G","L2","PZA","D","D49",49,"G",1,"MDR","DM","hydrophilic","hydrophobic","acidic","neutral","neg","non-polar",3.452,-3.463,-1.157,0.460983,-2.415,-1.08,83,91,-1.188,9,9,7,0.0362694300518134,"strand",-1.53333333333333,7.89,0.0005030904125341,29.1630847029077,29.1630732435189,29.1293325978315,18.6717493808583,28,30,0,0,30,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-1,6,0,9,19,-0.877152988855116,-0.298966408268734,0.0167900042978169,-0.411764705882353,-0.282722513089005,0.873684210526316,-0.978583196046129,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","T:D",3.37290329402599,0.0017890770828182,1.07995768762032,3.12318096596744,4.97876379054023,550.894323518622,1.46483345924118,0.0001485295621003,3.828187099348,3.53443753556636,1331.56873199938,1.55265977742841e-05,"lineage2","dr_mutations_pyrazinamide","GLY",0,"SAMN10961406","SRR8651624","lineage2.2.1","cn","China:Wenzhou","pnca_p.asp49gly","A","E","ASP","DA49","pnca_complex.pdb"
|
|
"D49G","L4","PZA","D","D49",49,"G",NA,"XDR","DM","hydrophilic","hydrophobic","acidic","neutral","neg","non-polar",3.452,-3.463,-1.157,0.460983,-2.415,-1.08,83,91,-1.188,9,9,7,0.0362694300518134,"strand",-1.53333333333333,7.89,0.0005030904125341,29.1630847029077,29.1630732435189,29.1293325978315,18.6717493808583,28,30,0,0,30,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-1,6,0,9,19,-0.877152988855116,-0.298966408268734,0.0167900042978169,-0.411764705882353,-0.282722513089005,0.873684210526316,-0.978583196046129,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","T:D",3.37290329402599,0.0017890770828182,1.07995768762032,3.12318096596744,4.97876379054023,550.894323518622,1.46483345924118,0.0001485295621003,3.828187099348,3.53443753556636,1331.56873199938,1.55265977742841e-05,"lineage4","dr_mutations_pyrazinamide","GLY",0,"SAMN02419622","SRR1172185_SRR1163412_SRR1163189_SRR1169058","lineage4.3.3","by","Belarus","pnca_p.asp49gly","A","E","ASP","DA49","pnca_complex.pdb"
|
|
"D49G","L4","PZA","D","D49",49,"G",NA,"XDR","DM","hydrophilic","hydrophobic","acidic","neutral","neg","non-polar",3.452,-3.463,-1.157,0.460983,-2.415,-1.08,83,91,-1.188,9,9,7,0.0362694300518134,"strand",-1.53333333333333,7.89,0.0005030904125341,29.1630847029077,29.1630732435189,29.1293325978315,18.6717493808583,28,30,0,0,30,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-1,6,0,9,19,-0.877152988855116,-0.298966408268734,0.0167900042978169,-0.411764705882353,-0.282722513089005,0.873684210526316,-0.978583196046129,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","T:D",3.37290329402599,0.0017890770828182,1.07995768762032,3.12318096596744,4.97876379054023,550.894323518622,1.46483345924118,0.0001485295621003,3.828187099348,3.53443753556636,1331.56873199938,1.55265977742841e-05,"lineage4","dr_mutations_pyrazinamide","GLY",0,"SAMN02419678","SRR1172393_SRR1163399_SRR1163204_SRR1169040","lineage4.3.3","by","Belarus","pnca_p.asp49gly","A","E","ASP","DA49","pnca_complex.pdb"
|
|
"D49G","L4","PZA","D","D49",49,"G",NA,"Pre-XDR","DM","hydrophilic","hydrophobic","acidic","neutral","neg","non-polar",3.452,-3.463,-1.157,0.460983,-2.415,-1.08,83,91,-1.188,9,9,7,0.0362694300518134,"strand",-1.53333333333333,7.89,0.0005030904125341,29.1630847029077,29.1630732435189,29.1293325978315,18.6717493808583,28,30,0,0,30,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-1,6,0,9,19,-0.877152988855116,-0.298966408268734,0.0167900042978169,-0.411764705882353,-0.282722513089005,0.873684210526316,-0.978583196046129,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","T:D",3.37290329402599,0.0017890770828182,1.07995768762032,3.12318096596744,4.97876379054023,550.894323518622,1.46483345924118,0.0001485295621003,3.828187099348,3.53443753556636,1331.56873199938,1.55265977742841e-05,"lineage4","dr_mutations_pyrazinamide","GLY",0,"SAMN02419671","SRR1163342_SRR1168975_SRR1163006_SRR1172438","lineage4.3.3","by","Belarus","pnca_p.asp49gly","A","E","ASP","DA49","pnca_complex.pdb"
|
|
"D49G","L4","PZA","D","D49",49,"G",NA,"Pre-XDR","DM","hydrophilic","hydrophobic","acidic","neutral","neg","non-polar",3.452,-3.463,-1.157,0.460983,-2.415,-1.08,83,91,-1.188,9,9,7,0.0362694300518134,"strand",-1.53333333333333,7.89,0.0005030904125341,29.1630847029077,29.1630732435189,29.1293325978315,18.6717493808583,28,30,0,0,30,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-1,6,0,9,19,-0.877152988855116,-0.298966408268734,0.0167900042978169,-0.411764705882353,-0.282722513089005,0.873684210526316,-0.978583196046129,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","T:D",3.37290329402599,0.0017890770828182,1.07995768762032,3.12318096596744,4.97876379054023,550.894323518622,1.46483345924118,0.0001485295621003,3.828187099348,3.53443753556636,1331.56873199938,1.55265977742841e-05,"lineage4","dr_mutations_pyrazinamide","GLY",0,"SAMN02419657","SRR1163185_SRR1169075_SRR1163286_SRR1174850","lineage4.3.3","by","Belarus","pnca_p.asp49gly","A","E","ASP","DA49","pnca_complex.pdb"
|
|
"D49G","L2","PZA","D","D49",49,"G",1,"MDR","DM","hydrophilic","hydrophobic","acidic","neutral","neg","non-polar",3.452,-3.463,-1.157,0.460983,-2.415,-1.08,83,91,-1.188,9,9,7,0.0362694300518134,"strand",-1.53333333333333,7.89,0.0005030904125341,29.1630847029077,29.1630732435189,29.1293325978315,18.6717493808583,28,30,0,0,30,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-1,6,0,9,19,-0.877152988855116,-0.298966408268734,0.0167900042978169,-0.411764705882353,-0.282722513089005,0.873684210526316,-0.978583196046129,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","T:D",3.37290329402599,0.0017890770828182,1.07995768762032,3.12318096596744,4.97876379054023,550.894323518622,1.46483345924118,0.0001485295621003,3.828187099348,3.53443753556636,1331.56873199938,1.55265977742841e-05,"lineage2","dr_mutations_pyrazinamide","GLY",0,"SAMN01925690","SRR924240_SRR847786","lineage2.2.1","za","South Africa","pnca_p.asp49gly","A","E","ASP","DA49","pnca_complex.pdb"
|
|
"D49G","L4","PZA","D","D49",49,"G",NA,"Pre-XDR","DM","hydrophilic","hydrophobic","acidic","neutral","neg","non-polar",3.452,-3.463,-1.157,0.460983,-2.415,-1.08,83,91,-1.188,9,9,7,0.0362694300518134,"strand",-1.53333333333333,7.89,0.0005030904125341,29.1630847029077,29.1630732435189,29.1293325978315,18.6717493808583,28,30,0,0,30,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-1,6,0,9,19,-0.877152988855116,-0.298966408268734,0.0167900042978169,-0.411764705882353,-0.282722513089005,0.873684210526316,-0.978583196046129,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","T:D",3.37290329402599,0.0017890770828182,1.07995768762032,3.12318096596744,4.97876379054023,550.894323518622,1.46483345924118,0.0001485295621003,3.828187099348,3.53443753556636,1331.56873199938,1.55265977742841e-05,"lineage4","dr_mutations_pyrazinamide","GLY",0,"SAMN02419551","SRR1159303_SRR1181204_SRR1181128_SRR1159002","lineage4.3.3","by","Belarus","pnca_p.asp49gly","A","E","ASP","DA49","pnca_complex.pdb"
|
|
"D49N","L4","PZA","D","D49",49,"N",NA,"MDR","DM","hydrophilic","hydrophilic","acidic","neutral","neg","polar",3.452,-1.932,-1.684,-0.334669,-2.857,-1.45,76,85,-1.188,9,9,7,0.0362694300518134,"strand",-1.53333333333333,7.89,0.0005749604714675,77.8405735976381,1394626.35223403,Inf,33.1802749271012,0,32,0,0,32,0,0,0,0,-2,0,0,-2,0,0,0,0,-6,0,0,-6,-2,0,0,0,-0.48936170212766,-0.435142118863049,-0.064344574329001,-0.487127024722933,-0.379581151832461,0.8,-0.978583196046129,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","T:D",14.148137089499,0.901927875940367,114.814237034002,0.123226330244298,82.9586021424457,NA,1.89120602753485,7.2326389241213e-07,6.1407032156959,8.29603358299821,Inf,8.39983046099388e-09,"lineage4","dr_mutations_pyrazinamide","ASN",0,"ERR775328","ERR775328","lineage4.3.3","pe","","pnca_p.asp49asn","A","E","ASP","DA49","pnca_complex.pdb"
|
|
"D49N","L4","PZA","D","D49",49,"N",NA,"MDR","DM","hydrophilic","hydrophilic","acidic","neutral","neg","polar",3.452,-1.932,-1.684,-0.334669,-2.857,-1.45,76,85,-1.188,9,9,7,0.0362694300518134,"strand",-1.53333333333333,7.89,0.0005749604714675,77.8405735976381,1394626.35223403,Inf,33.1802749271012,0,32,0,0,32,0,0,0,0,-2,0,0,-2,0,0,0,0,-6,0,0,-6,-2,0,0,0,-0.48936170212766,-0.435142118863049,-0.064344574329001,-0.487127024722933,-0.379581151832461,0.8,-0.978583196046129,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","T:D",14.148137089499,0.901927875940367,114.814237034002,0.123226330244298,82.9586021424457,NA,1.89120602753485,7.2326389241213e-07,6.1407032156959,8.29603358299821,Inf,8.39983046099388e-09,"lineage4","dr_mutations_pyrazinamide","ASN",0,"ERR751616","ERR751616","lineage4.3.3","pe","","pnca_p.asp49asn","A","E","ASP","DA49","pnca_complex.pdb"
|
|
"D49N","L4","PZA","D","D49",49,"N",NA,"MDR","DM","hydrophilic","hydrophilic","acidic","neutral","neg","polar",3.452,-1.932,-1.684,-0.334669,-2.857,-1.45,76,85,-1.188,9,9,7,0.0362694300518134,"strand",-1.53333333333333,7.89,0.0005749604714675,77.8405735976381,1394626.35223403,Inf,33.1802749271012,0,32,0,0,32,0,0,0,0,-2,0,0,-2,0,0,0,0,-6,0,0,-6,-2,0,0,0,-0.48936170212766,-0.435142118863049,-0.064344574329001,-0.487127024722933,-0.379581151832461,0.8,-0.978583196046129,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","T:D",14.148137089499,0.901927875940367,114.814237034002,0.123226330244298,82.9586021424457,NA,1.89120602753485,7.2326389241213e-07,6.1407032156959,8.29603358299821,Inf,8.39983046099388e-09,"lineage4","dr_mutations_pyrazinamide","ASN",0,"ERR751571","ERR751571","lineage4.3.3","pe","","pnca_p.asp49asn","A","E","ASP","DA49","pnca_complex.pdb"
|
|
"D49N","L2","PZA","D","D49",49,"N",1,"Pre-XDR","DM","hydrophilic","hydrophilic","acidic","neutral","neg","polar",3.452,-1.932,-1.684,-0.334669,-2.857,-1.45,76,85,-1.188,9,9,7,0.0362694300518134,"strand",-1.53333333333333,7.89,0.0005749604714675,77.8405735976381,1394626.35223403,Inf,33.1802749271012,0,32,0,0,32,0,0,0,0,-2,0,0,-2,0,0,0,0,-6,0,0,-6,-2,0,0,0,-0.48936170212766,-0.435142118863049,-0.064344574329001,-0.487127024722933,-0.379581151832461,0.8,-0.978583196046129,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","T:D",14.148137089499,0.901927875940367,114.814237034002,0.123226330244298,82.9586021424457,NA,1.89120602753485,7.2326389241213e-07,6.1407032156959,8.29603358299821,Inf,8.39983046099388e-09,"lineage2","dr_mutations_pyrazinamide","ASN",0,"ERR2510714","ERR2510714","lineage2.2.1","it","Italy","pnca_p.asp49asn","A","E","ASP","DA49","pnca_complex.pdb"
|
|
"D49N","L4","PZA","D","D49",49,"N",1,"MDR","DM","hydrophilic","hydrophilic","acidic","neutral","neg","polar",3.452,-1.932,-1.684,-0.334669,-2.857,-1.45,76,85,-1.188,9,9,7,0.0362694300518134,"strand",-1.53333333333333,7.89,0.0005749604714675,77.8405735976381,1394626.35223403,Inf,33.1802749271012,0,32,0,0,32,0,0,0,0,-2,0,0,-2,0,0,0,0,-6,0,0,-6,-2,0,0,0,-0.48936170212766,-0.435142118863049,-0.064344574329001,-0.487127024722933,-0.379581151832461,0.8,-0.978583196046129,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","T:D",14.148137089499,0.901927875940367,114.814237034002,0.123226330244298,82.9586021424457,NA,1.89120602753485,7.2326389241213e-07,6.1407032156959,8.29603358299821,Inf,8.39983046099388e-09,"lineage4","dr_mutations_pyrazinamide","ASN",0,"ERR1034748","ERR1034748","lineage4.3.3","pe","Peru","pnca_p.asp49asn","A","E","ASP","DA49","pnca_complex.pdb"
|
|
"D49N","L3","PZA","D","D49",49,"N",1,"Pre-XDR","DM","hydrophilic","hydrophilic","acidic","neutral","neg","polar",3.452,-1.932,-1.684,-0.334669,-2.857,-1.45,76,85,-1.188,9,9,7,0.0362694300518134,"strand",-1.53333333333333,7.89,0.0005749604714675,77.8405735976381,1394626.35223403,Inf,33.1802749271012,0,32,0,0,32,0,0,0,0,-2,0,0,-2,0,0,0,0,-6,0,0,-6,-2,0,0,0,-0.48936170212766,-0.435142118863049,-0.064344574329001,-0.487127024722933,-0.379581151832461,0.8,-0.978583196046129,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","T:D",14.148137089499,0.901927875940367,114.814237034002,0.123226330244298,82.9586021424457,NA,1.89120602753485,7.2326389241213e-07,6.1407032156959,8.29603358299821,Inf,8.39983046099388e-09,"lineage3","dr_mutations_pyrazinamide","ASN",0,"ERR3335766","ERR3335766","lineage3","pk","Pakistan","pnca_p.asp49asn","A","E","ASP","DA49","pnca_complex.pdb"
|
|
"D49N","L3","PZA","D","D49",49,"N",1,"MDR","DM","hydrophilic","hydrophilic","acidic","neutral","neg","polar",3.452,-1.932,-1.684,-0.334669,-2.857,-1.45,76,85,-1.188,9,9,7,0.0362694300518134,"strand",-1.53333333333333,7.89,0.0005749604714675,77.8405735976381,1394626.35223403,Inf,33.1802749271012,0,32,0,0,32,0,0,0,0,-2,0,0,-2,0,0,0,0,-6,0,0,-6,-2,0,0,0,-0.48936170212766,-0.435142118863049,-0.064344574329001,-0.487127024722933,-0.379581151832461,0.8,-0.978583196046129,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","T:D",14.148137089499,0.901927875940367,114.814237034002,0.123226330244298,82.9586021424457,NA,1.89120602753485,7.2326389241213e-07,6.1407032156959,8.29603358299821,Inf,8.39983046099388e-09,"lineage3","dr_mutations_pyrazinamide","ASN",0,"SAMN03648094,SRR2100921","SRR2100921","lineage3","","","pnca_p.asp49asn","A","E","ASP","DA49","pnca_complex.pdb"
|
|
"D49N","L2","PZA","D","D49",49,"N",NA,"Pre-XDR","DM","hydrophilic","hydrophilic","acidic","neutral","neg","polar",3.452,-1.932,-1.684,-0.334669,-2.857,-1.45,76,85,-1.188,9,9,7,0.0362694300518134,"strand",-1.53333333333333,7.89,0.0005749604714675,77.8405735976381,1394626.35223403,Inf,33.1802749271012,0,32,0,0,32,0,0,0,0,-2,0,0,-2,0,0,0,0,-6,0,0,-6,-2,0,0,0,-0.48936170212766,-0.435142118863049,-0.064344574329001,-0.487127024722933,-0.379581151832461,0.8,-0.978583196046129,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","T:D",14.148137089499,0.901927875940367,114.814237034002,0.123226330244298,82.9586021424457,NA,1.89120602753485,7.2326389241213e-07,6.1407032156959,8.29603358299821,Inf,8.39983046099388e-09,"lineage2","dr_mutations_pyrazinamide","ASN",0,"ERR2516438","ERR2516438","lineage2.2.1","nl","Netherlands","pnca_p.asp49asn","A","E","ASP","DA49","pnca_complex.pdb"
|
|
"D49N","L4","PZA","D","D49",49,"N",NA,"MDR","DM","hydrophilic","hydrophilic","acidic","neutral","neg","polar",3.452,-1.932,-1.684,-0.334669,-2.857,-1.45,76,85,-1.188,9,9,7,0.0362694300518134,"strand",-1.53333333333333,7.89,0.0005749604714675,77.8405735976381,1394626.35223403,Inf,33.1802749271012,0,32,0,0,32,0,0,0,0,-2,0,0,-2,0,0,0,0,-6,0,0,-6,-2,0,0,0,-0.48936170212766,-0.435142118863049,-0.064344574329001,-0.487127024722933,-0.379581151832461,0.8,-0.978583196046129,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","T:D",14.148137089499,0.901927875940367,114.814237034002,0.123226330244298,82.9586021424457,NA,1.89120602753485,7.2326389241213e-07,6.1407032156959,8.29603358299821,Inf,8.39983046099388e-09,"lineage4","dr_mutations_pyrazinamide","ASN",0,"ERR1034757","ERR1034757","lineage4.3.4.1;lineage4.3.3","pe","Peru","pnca_p.asp49asn","A","E","ASP","DA49","pnca_complex.pdb"
|
|
"D49N","L2","PZA","D","D49",49,"N",NA,"Pre-XDR","DM","hydrophilic","hydrophilic","acidic","neutral","neg","polar",3.452,-1.932,-1.684,-0.334669,-2.857,-1.45,76,85,-1.188,9,9,7,0.0362694300518134,"strand",-1.53333333333333,7.89,0.0005749604714675,77.8405735976381,1394626.35223403,Inf,33.1802749271012,0,32,0,0,32,0,0,0,0,-2,0,0,-2,0,0,0,0,-6,0,0,-6,-2,0,0,0,-0.48936170212766,-0.435142118863049,-0.064344574329001,-0.487127024722933,-0.379581151832461,0.8,-0.978583196046129,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","T:D",14.148137089499,0.901927875940367,114.814237034002,0.123226330244298,82.9586021424457,NA,1.89120602753485,7.2326389241213e-07,6.1407032156959,8.29603358299821,Inf,8.39983046099388e-09,"lineage2","dr_mutations_pyrazinamide","ASN",0,"ERR1034893","ERR1034893","lineage2.2.1","pt","Portugal","pnca_p.asp49asn","A","E","ASP","DA49","pnca_complex.pdb"
|
|
"D49N","L4","PZA","D","D49",49,"N",NA,"MDR","DM","hydrophilic","hydrophilic","acidic","neutral","neg","polar",3.452,-1.932,-1.684,-0.334669,-2.857,-1.45,76,85,-1.188,9,9,7,0.0362694300518134,"strand",-1.53333333333333,7.89,0.0005749604714675,77.8405735976381,1394626.35223403,Inf,33.1802749271012,0,32,0,0,32,0,0,0,0,-2,0,0,-2,0,0,0,0,-6,0,0,-6,-2,0,0,0,-0.48936170212766,-0.435142118863049,-0.064344574329001,-0.487127024722933,-0.379581151832461,0.8,-0.978583196046129,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","T:D",14.148137089499,0.901927875940367,114.814237034002,0.123226330244298,82.9586021424457,NA,1.89120602753485,7.2326389241213e-07,6.1407032156959,8.29603358299821,Inf,8.39983046099388e-09,"lineage4","dr_mutations_pyrazinamide","ASN",0,"ERR751543","ERR751543","lineage4.3.3","pe","","pnca_p.asp49asn","A","E","ASP","DA49","pnca_complex.pdb"
|
|
"D49N","L4","PZA","D","D49",49,"N",1,"MDR","DM","hydrophilic","hydrophilic","acidic","neutral","neg","polar",3.452,-1.932,-1.684,-0.334669,-2.857,-1.45,76,85,-1.188,9,9,7,0.0362694300518134,"strand",-1.53333333333333,7.89,0.0005749604714675,77.8405735976381,1394626.35223403,Inf,33.1802749271012,0,32,0,0,32,0,0,0,0,-2,0,0,-2,0,0,0,0,-6,0,0,-6,-2,0,0,0,-0.48936170212766,-0.435142118863049,-0.064344574329001,-0.487127024722933,-0.379581151832461,0.8,-0.978583196046129,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","T:D",14.148137089499,0.901927875940367,114.814237034002,0.123226330244298,82.9586021424457,NA,1.89120602753485,7.2326389241213e-07,6.1407032156959,8.29603358299821,Inf,8.39983046099388e-09,"lineage4","dr_mutations_pyrazinamide","ASN",0,"ERR1034798","ERR1034798","lineage4.3.3","pe","Peru","pnca_p.asp49asn","A","E","ASP","DA49","pnca_complex.pdb"
|
|
"D49N","L4","PZA","D","D49",49,"N",1,"MDR","DM","hydrophilic","hydrophilic","acidic","neutral","neg","polar",3.452,-1.932,-1.684,-0.334669,-2.857,-1.45,76,85,-1.188,9,9,7,0.0362694300518134,"strand",-1.53333333333333,7.89,0.0005749604714675,77.8405735976381,1394626.35223403,Inf,33.1802749271012,0,32,0,0,32,0,0,0,0,-2,0,0,-2,0,0,0,0,-6,0,0,-6,-2,0,0,0,-0.48936170212766,-0.435142118863049,-0.064344574329001,-0.487127024722933,-0.379581151832461,0.8,-0.978583196046129,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","T:D",14.148137089499,0.901927875940367,114.814237034002,0.123226330244298,82.9586021424457,NA,1.89120602753485,7.2326389241213e-07,6.1407032156959,8.29603358299821,Inf,8.39983046099388e-09,"lineage4","dr_mutations_pyrazinamide","ASN",0,"ERR1034750","ERR1034750","lineage4.3.3","pe","Peru","pnca_p.asp49asn","A","E","ASP","DA49","pnca_complex.pdb"
|
|
"D49N","L4","PZA","D","D49",49,"N",1,"Pre-XDR","DM","hydrophilic","hydrophilic","acidic","neutral","neg","polar",3.452,-1.932,-1.684,-0.334669,-2.857,-1.45,76,85,-1.188,9,9,7,0.0362694300518134,"strand",-1.53333333333333,7.89,0.0005749604714675,77.8405735976381,1394626.35223403,Inf,33.1802749271012,0,32,0,0,32,0,0,0,0,-2,0,0,-2,0,0,0,0,-6,0,0,-6,-2,0,0,0,-0.48936170212766,-0.435142118863049,-0.064344574329001,-0.487127024722933,-0.379581151832461,0.8,-0.978583196046129,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","T:D",14.148137089499,0.901927875940367,114.814237034002,0.123226330244298,82.9586021424457,NA,1.89120602753485,7.2326389241213e-07,6.1407032156959,8.29603358299821,Inf,8.39983046099388e-09,"lineage4","dr_mutations_pyrazinamide","ASN",0,"ERR2516404","ERR2516404","lineage4.3.2","pe","Peru","pnca_p.asp49asn","A","E","ASP","DA49","pnca_complex.pdb"
|
|
"D49N","L4","PZA","D","D49",49,"N",NA,"MDR","DM","hydrophilic","hydrophilic","acidic","neutral","neg","polar",3.452,-1.932,-1.684,-0.334669,-2.857,-1.45,76,85,-1.188,9,9,7,0.0362694300518134,"strand",-1.53333333333333,7.89,0.0005749604714675,77.8405735976381,1394626.35223403,Inf,33.1802749271012,0,32,0,0,32,0,0,0,0,-2,0,0,-2,0,0,0,0,-6,0,0,-6,-2,0,0,0,-0.48936170212766,-0.435142118863049,-0.064344574329001,-0.487127024722933,-0.379581151832461,0.8,-0.978583196046129,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","T:D",14.148137089499,0.901927875940367,114.814237034002,0.123226330244298,82.9586021424457,NA,1.89120602753485,7.2326389241213e-07,6.1407032156959,8.29603358299821,Inf,8.39983046099388e-09,"lineage4","dr_mutations_pyrazinamide","ASN",0,"ERR751416","ERR751416","lineage4.3.3","pe","","pnca_p.asp49asn","A","E","ASP","DA49","pnca_complex.pdb"
|
|
"D49N","L3","PZA","D","D49",49,"N",1,"MDR","DM","hydrophilic","hydrophilic","acidic","neutral","neg","polar",3.452,-1.932,-1.684,-0.334669,-2.857,-1.45,76,85,-1.188,9,9,7,0.0362694300518134,"strand",-1.53333333333333,7.89,0.0005749604714675,77.8405735976381,1394626.35223403,Inf,33.1802749271012,0,32,0,0,32,0,0,0,0,-2,0,0,-2,0,0,0,0,-6,0,0,-6,-2,0,0,0,-0.48936170212766,-0.435142118863049,-0.064344574329001,-0.487127024722933,-0.379581151832461,0.8,-0.978583196046129,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","T:D",14.148137089499,0.901927875940367,114.814237034002,0.123226330244298,82.9586021424457,NA,1.89120602753485,7.2326389241213e-07,6.1407032156959,8.29603358299821,Inf,8.39983046099388e-09,"lineage3","dr_mutations_pyrazinamide","ASN",0,"ERR2516940","ERR2516940","lineage3","gb","UK","pnca_p.asp49asn","A","E","ASP","DA49","pnca_complex.pdb"
|
|
"D49N","L4","PZA","D","D49",49,"N",NA,"MDR","DM","hydrophilic","hydrophilic","acidic","neutral","neg","polar",3.452,-1.932,-1.684,-0.334669,-2.857,-1.45,76,85,-1.188,9,9,7,0.0362694300518134,"strand",-1.53333333333333,7.89,0.0005749604714675,77.8405735976381,1394626.35223403,Inf,33.1802749271012,0,32,0,0,32,0,0,0,0,-2,0,0,-2,0,0,0,0,-6,0,0,-6,-2,0,0,0,-0.48936170212766,-0.435142118863049,-0.064344574329001,-0.487127024722933,-0.379581151832461,0.8,-0.978583196046129,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","T:D",14.148137089499,0.901927875940367,114.814237034002,0.123226330244298,82.9586021424457,NA,1.89120602753485,7.2326389241213e-07,6.1407032156959,8.29603358299821,Inf,8.39983046099388e-09,"lineage4","dr_mutations_pyrazinamide","ASN",0,"ERR2510153","ERR2510153","lineage4.3.3","pe","Peru","pnca_p.asp49asn","A","E","ASP","DA49","pnca_complex.pdb"
|
|
"D49Y","L4","PZA","D","D49",49,"Y",1,"MDR","DM","hydrophilic","hydrophobic","acidic","neutral","neg","polar",3.452,-1.855,-0.739,-2.66914,-0.988,-1.64,85,91,-1.188,9,9,7,0.0362694300518134,"strand",-1.53333333333333,7.89,7.18700589334483e-05,9.70142977291842,188179.926264654,Inf,0.763784339928386,-42,20,0,0,20,0,0,0,0,-2,0,0,-4,0,0,0,0,-14,0,-4,-10,-14,0,-12,-12,-0.469858156028369,-0.190956072351421,-0.513177728216565,-0.16845694799659,-0.429319371727749,0.894736842105263,-0.978583196046129,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","T:D",12.1451538387266,0.919026337424238,119.468044436239,0.10166027154825,5.0115366606202e-06,NA,0.986835744238421,0.170978870202674,0.767057556984365,0.124324963210678,Inf,0.382146811758261,"lineage4","dr_mutations_pyrazinamide","TYR",0,"ERR2510658","ERR2510658","lineage4.3.3","it","Italy","pnca_p.asp49tyr","A","E","ASP","DA49","pnca_complex.pdb"
|
|
"D49Y","L2","PZA","D","D49",49,"Y",NA,"XDR","DM","hydrophilic","hydrophobic","acidic","neutral","neg","polar",3.452,-1.855,-0.739,-2.66914,-0.988,-1.64,85,91,-1.188,9,9,7,0.0362694300518134,"strand",-1.53333333333333,7.89,7.18700589334483e-05,9.70142977291842,188179.926264654,Inf,0.763784339928386,-42,20,0,0,20,0,0,0,0,-2,0,0,-4,0,0,0,0,-14,0,-4,-10,-14,0,-12,-12,-0.469858156028369,-0.190956072351421,-0.513177728216565,-0.16845694799659,-0.429319371727749,0.894736842105263,-0.978583196046129,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","T:D",12.1451538387266,0.919026337424238,119.468044436239,0.10166027154825,5.0115366606202e-06,NA,0.986835744238421,0.170978870202674,0.767057556984365,0.124324963210678,Inf,0.382146811758261,"lineage2","dr_mutations_pyrazinamide","TYR",0,"SAMN02419679","SRR1174839_SRR1163178_SRR1169140_SRR1163380","lineage2.2.1","by","Belarus","pnca_p.asp49tyr","A","E","ASP","DA49","pnca_complex.pdb"
|
|
"H51D","L4","PZA","H","H51",51,"D",1,"Pre-MDR","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",5.661,-1.821,-2.198,4.34022,-1.814,-1.67,82,91,-1.189,9,9,1,0.0044642857142857,"strand",1.36666666666667,6.97,0.0030185424752048,414.608472400514,10454944.8180635,Inf,198.436695636911,16,-28,0,0,-28,0,0,0,0,2,0,2,0,0,0,0,0,4,0,2,2,2,0,4,4,-0.461246200607903,-0.567958656330749,0.158080259908653,-0.309292412617221,-0.43717277486911,0.863157894736842,-0.979406919275124,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","H:Y",16.1625856127882,0.905545449550291,136.210261834263,0.118659089228199,26043.5577250657,1.23987518604392e+26,2.61763817252677,4.4914140361843e-33,32.347616908121,53.6831618314533,Inf,4.58127580776551e-45,"lineage4","dr_mutations_pyrazinamide","ASP",0,"ERR552878","ERR552878","lineage4.4.1.1","sz","Swaziland","pnca_p.his51asp","A","B","HIS","HA51","pnca_complex.pdb"
|
|
"H51D","L4","PZA","H","H51",51,"D",1,"MDR","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",5.661,-1.821,-2.198,4.34022,-1.814,-1.67,82,91,-1.189,9,9,1,0.0044642857142857,"strand",1.36666666666667,6.97,0.0030185424752048,414.608472400514,10454944.8180635,Inf,198.436695636911,16,-28,0,0,-28,0,0,0,0,2,0,2,0,0,0,0,0,4,0,2,2,2,0,4,4,-0.461246200607903,-0.567958656330749,0.158080259908653,-0.309292412617221,-0.43717277486911,0.863157894736842,-0.979406919275124,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","H:Y",16.1625856127882,0.905545449550291,136.210261834263,0.118659089228199,26043.5577250657,1.23987518604392e+26,2.61763817252677,4.4914140361843e-33,32.347616908121,53.6831618314533,Inf,4.58127580776551e-45,"lineage4","dr_mutations_pyrazinamide","ASP",0,"ERR552540","ERR552540","lineage4.4.1.1","sz","Swaziland","pnca_p.his51asp","A","B","HIS","HA51","pnca_complex.pdb"
|
|
"H51D","L4","PZA","H","H51",51,"D",1,"MDR","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",5.661,-1.821,-2.198,4.34022,-1.814,-1.67,82,91,-1.189,9,9,1,0.0044642857142857,"strand",1.36666666666667,6.97,0.0030185424752048,414.608472400514,10454944.8180635,Inf,198.436695636911,16,-28,0,0,-28,0,0,0,0,2,0,2,0,0,0,0,0,4,0,2,2,2,0,4,4,-0.461246200607903,-0.567958656330749,0.158080259908653,-0.309292412617221,-0.43717277486911,0.863157894736842,-0.979406919275124,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","H:Y",16.1625856127882,0.905545449550291,136.210261834263,0.118659089228199,26043.5577250657,1.23987518604392e+26,2.61763817252677,4.4914140361843e-33,32.347616908121,53.6831618314533,Inf,4.58127580776551e-45,"lineage4","dr_mutations_pyrazinamide","ASP",0,"ERR552083","ERR552083","lineage4.4.1.1","sz","Swaziland","pnca_p.his51asp","A","B","HIS","HA51","pnca_complex.pdb"
|
|
"H51D","L4","PZA","H","H51",51,"D",1,"MDR","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",5.661,-1.821,-2.198,4.34022,-1.814,-1.67,82,91,-1.189,9,9,1,0.0044642857142857,"strand",1.36666666666667,6.97,0.0030185424752048,414.608472400514,10454944.8180635,Inf,198.436695636911,16,-28,0,0,-28,0,0,0,0,2,0,2,0,0,0,0,0,4,0,2,2,2,0,4,4,-0.461246200607903,-0.567958656330749,0.158080259908653,-0.309292412617221,-0.43717277486911,0.863157894736842,-0.979406919275124,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","H:Y",16.1625856127882,0.905545449550291,136.210261834263,0.118659089228199,26043.5577250657,1.23987518604392e+26,2.61763817252677,4.4914140361843e-33,32.347616908121,53.6831618314533,Inf,4.58127580776551e-45,"lineage4","dr_mutations_pyrazinamide","ASP",0,"ERR551195","ERR551195","lineage4.4.1.1","sz","Swaziland","pnca_p.his51asp","A","B","HIS","HA51","pnca_complex.pdb"
|
|
"H51D","L4","PZA","H","H51",51,"D",1,"MDR","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",5.661,-1.821,-2.198,4.34022,-1.814,-1.67,82,91,-1.189,9,9,1,0.0044642857142857,"strand",1.36666666666667,6.97,0.0030185424752048,414.608472400514,10454944.8180635,Inf,198.436695636911,16,-28,0,0,-28,0,0,0,0,2,0,2,0,0,0,0,0,4,0,2,2,2,0,4,4,-0.461246200607903,-0.567958656330749,0.158080259908653,-0.309292412617221,-0.43717277486911,0.863157894736842,-0.979406919275124,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","H:Y",16.1625856127882,0.905545449550291,136.210261834263,0.118659089228199,26043.5577250657,1.23987518604392e+26,2.61763817252677,4.4914140361843e-33,32.347616908121,53.6831618314533,Inf,4.58127580776551e-45,"lineage4","dr_mutations_pyrazinamide","ASP",0,"ERR552254","ERR552254","lineage4.4.1.1","sz","Swaziland","pnca_p.his51asp","A","B","HIS","HA51","pnca_complex.pdb"
|
|
"H51D","L4","PZA","H","H51",51,"D",1,"MDR","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",5.661,-1.821,-2.198,4.34022,-1.814,-1.67,82,91,-1.189,9,9,1,0.0044642857142857,"strand",1.36666666666667,6.97,0.0030185424752048,414.608472400514,10454944.8180635,Inf,198.436695636911,16,-28,0,0,-28,0,0,0,0,2,0,2,0,0,0,0,0,4,0,2,2,2,0,4,4,-0.461246200607903,-0.567958656330749,0.158080259908653,-0.309292412617221,-0.43717277486911,0.863157894736842,-0.979406919275124,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","H:Y",16.1625856127882,0.905545449550291,136.210261834263,0.118659089228199,26043.5577250657,1.23987518604392e+26,2.61763817252677,4.4914140361843e-33,32.347616908121,53.6831618314533,Inf,4.58127580776551e-45,"lineage4","dr_mutations_pyrazinamide","ASP",0,"ERR551536","ERR551536","lineage4.4.1.1","sz","Swaziland","pnca_p.his51asp","A","B","HIS","HA51","pnca_complex.pdb"
|
|
"H51D","L4","PZA","H","H51",51,"D",1,"MDR","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",5.661,-1.821,-2.198,4.34022,-1.814,-1.67,82,91,-1.189,9,9,1,0.0044642857142857,"strand",1.36666666666667,6.97,0.0030185424752048,414.608472400514,10454944.8180635,Inf,198.436695636911,16,-28,0,0,-28,0,0,0,0,2,0,2,0,0,0,0,0,4,0,2,2,2,0,4,4,-0.461246200607903,-0.567958656330749,0.158080259908653,-0.309292412617221,-0.43717277486911,0.863157894736842,-0.979406919275124,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","H:Y",16.1625856127882,0.905545449550291,136.210261834263,0.118659089228199,26043.5577250657,1.23987518604392e+26,2.61763817252677,4.4914140361843e-33,32.347616908121,53.6831618314533,Inf,4.58127580776551e-45,"lineage4","dr_mutations_pyrazinamide","ASP",0,"ERR552487","ERR552487","lineage4.4.1.1","sz","Swaziland","pnca_p.his51asp","A","B","HIS","HA51","pnca_complex.pdb"
|
|
"H51D","L4","PZA","H","H51",51,"D",1,"MDR","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",5.661,-1.821,-2.198,4.34022,-1.814,-1.67,82,91,-1.189,9,9,1,0.0044642857142857,"strand",1.36666666666667,6.97,0.0030185424752048,414.608472400514,10454944.8180635,Inf,198.436695636911,16,-28,0,0,-28,0,0,0,0,2,0,2,0,0,0,0,0,4,0,2,2,2,0,4,4,-0.461246200607903,-0.567958656330749,0.158080259908653,-0.309292412617221,-0.43717277486911,0.863157894736842,-0.979406919275124,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","H:Y",16.1625856127882,0.905545449550291,136.210261834263,0.118659089228199,26043.5577250657,1.23987518604392e+26,2.61763817252677,4.4914140361843e-33,32.347616908121,53.6831618314533,Inf,4.58127580776551e-45,"lineage4","dr_mutations_pyrazinamide","ASP",0,"ERR553221","ERR553221","lineage4.4.1.1","sz","Swaziland","pnca_p.his51asp","A","B","HIS","HA51","pnca_complex.pdb"
|
|
"H51D","L4","PZA","H","H51",51,"D",1,"MDR","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",5.661,-1.821,-2.198,4.34022,-1.814,-1.67,82,91,-1.189,9,9,1,0.0044642857142857,"strand",1.36666666666667,6.97,0.0030185424752048,414.608472400514,10454944.8180635,Inf,198.436695636911,16,-28,0,0,-28,0,0,0,0,2,0,2,0,0,0,0,0,4,0,2,2,2,0,4,4,-0.461246200607903,-0.567958656330749,0.158080259908653,-0.309292412617221,-0.43717277486911,0.863157894736842,-0.979406919275124,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","H:Y",16.1625856127882,0.905545449550291,136.210261834263,0.118659089228199,26043.5577250657,1.23987518604392e+26,2.61763817252677,4.4914140361843e-33,32.347616908121,53.6831618314533,Inf,4.58127580776551e-45,"lineage4","dr_mutations_pyrazinamide","ASP",0,"ERR552573","ERR552573","lineage4.4.1.1","sz","Swaziland","pnca_p.his51asp","A","B","HIS","HA51","pnca_complex.pdb"
|
|
"H51D","L4","PZA","H","H51",51,"D",1,"MDR","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",5.661,-1.821,-2.198,4.34022,-1.814,-1.67,82,91,-1.189,9,9,1,0.0044642857142857,"strand",1.36666666666667,6.97,0.0030185424752048,414.608472400514,10454944.8180635,Inf,198.436695636911,16,-28,0,0,-28,0,0,0,0,2,0,2,0,0,0,0,0,4,0,2,2,2,0,4,4,-0.461246200607903,-0.567958656330749,0.158080259908653,-0.309292412617221,-0.43717277486911,0.863157894736842,-0.979406919275124,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","H:Y",16.1625856127882,0.905545449550291,136.210261834263,0.118659089228199,26043.5577250657,1.23987518604392e+26,2.61763817252677,4.4914140361843e-33,32.347616908121,53.6831618314533,Inf,4.58127580776551e-45,"lineage4","dr_mutations_pyrazinamide","ASP",0,"ERR552637","ERR552637","lineage4.4.1.1","sz","Swaziland","pnca_p.his51asp","A","B","HIS","HA51","pnca_complex.pdb"
|
|
"H51D","L4","PZA","H","H51",51,"D",1,"MDR","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",5.661,-1.821,-2.198,4.34022,-1.814,-1.67,82,91,-1.189,9,9,1,0.0044642857142857,"strand",1.36666666666667,6.97,0.0030185424752048,414.608472400514,10454944.8180635,Inf,198.436695636911,16,-28,0,0,-28,0,0,0,0,2,0,2,0,0,0,0,0,4,0,2,2,2,0,4,4,-0.461246200607903,-0.567958656330749,0.158080259908653,-0.309292412617221,-0.43717277486911,0.863157894736842,-0.979406919275124,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","H:Y",16.1625856127882,0.905545449550291,136.210261834263,0.118659089228199,26043.5577250657,1.23987518604392e+26,2.61763817252677,4.4914140361843e-33,32.347616908121,53.6831618314533,Inf,4.58127580776551e-45,"lineage4","dr_mutations_pyrazinamide","ASP",0,"ERR550741","ERR550741","lineage4.4.1.1","sz","Swaziland","pnca_p.his51asp","A","B","HIS","HA51","pnca_complex.pdb"
|
|
"H51D","L4","PZA","H","H51",51,"D",1,"MDR","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",5.661,-1.821,-2.198,4.34022,-1.814,-1.67,82,91,-1.189,9,9,1,0.0044642857142857,"strand",1.36666666666667,6.97,0.0030185424752048,414.608472400514,10454944.8180635,Inf,198.436695636911,16,-28,0,0,-28,0,0,0,0,2,0,2,0,0,0,0,0,4,0,2,2,2,0,4,4,-0.461246200607903,-0.567958656330749,0.158080259908653,-0.309292412617221,-0.43717277486911,0.863157894736842,-0.979406919275124,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","H:Y",16.1625856127882,0.905545449550291,136.210261834263,0.118659089228199,26043.5577250657,1.23987518604392e+26,2.61763817252677,4.4914140361843e-33,32.347616908121,53.6831618314533,Inf,4.58127580776551e-45,"lineage4","dr_mutations_pyrazinamide","ASP",0,"ERR552193","ERR552193","lineage4.4.1.1","sz","Swaziland","pnca_p.his51asp","A","B","HIS","HA51","pnca_complex.pdb"
|
|
"H51D","L4","PZA","H","H51",51,"D",1,"MDR","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",5.661,-1.821,-2.198,4.34022,-1.814,-1.67,82,91,-1.189,9,9,1,0.0044642857142857,"strand",1.36666666666667,6.97,0.0030185424752048,414.608472400514,10454944.8180635,Inf,198.436695636911,16,-28,0,0,-28,0,0,0,0,2,0,2,0,0,0,0,0,4,0,2,2,2,0,4,4,-0.461246200607903,-0.567958656330749,0.158080259908653,-0.309292412617221,-0.43717277486911,0.863157894736842,-0.979406919275124,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","H:Y",16.1625856127882,0.905545449550291,136.210261834263,0.118659089228199,26043.5577250657,1.23987518604392e+26,2.61763817252677,4.4914140361843e-33,32.347616908121,53.6831618314533,Inf,4.58127580776551e-45,"lineage4","dr_mutations_pyrazinamide","ASP",0,"ERR552405","ERR552405","lineage4.4.1.1","sz","Swaziland","pnca_p.his51asp","A","B","HIS","HA51","pnca_complex.pdb"
|
|
"H51D","L4","PZA","H","H51",51,"D",1,"MDR","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",5.661,-1.821,-2.198,4.34022,-1.814,-1.67,82,91,-1.189,9,9,1,0.0044642857142857,"strand",1.36666666666667,6.97,0.0030185424752048,414.608472400514,10454944.8180635,Inf,198.436695636911,16,-28,0,0,-28,0,0,0,0,2,0,2,0,0,0,0,0,4,0,2,2,2,0,4,4,-0.461246200607903,-0.567958656330749,0.158080259908653,-0.309292412617221,-0.43717277486911,0.863157894736842,-0.979406919275124,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","H:Y",16.1625856127882,0.905545449550291,136.210261834263,0.118659089228199,26043.5577250657,1.23987518604392e+26,2.61763817252677,4.4914140361843e-33,32.347616908121,53.6831618314533,Inf,4.58127580776551e-45,"lineage4","dr_mutations_pyrazinamide","ASP",0,"ERR551758","ERR551758","lineage4.4.1.1","sz","Swaziland","pnca_p.his51asp","A","B","HIS","HA51","pnca_complex.pdb"
|
|
"H51D","L4","PZA","H","H51",51,"D",1,"MDR","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",5.661,-1.821,-2.198,4.34022,-1.814,-1.67,82,91,-1.189,9,9,1,0.0044642857142857,"strand",1.36666666666667,6.97,0.0030185424752048,414.608472400514,10454944.8180635,Inf,198.436695636911,16,-28,0,0,-28,0,0,0,0,2,0,2,0,0,0,0,0,4,0,2,2,2,0,4,4,-0.461246200607903,-0.567958656330749,0.158080259908653,-0.309292412617221,-0.43717277486911,0.863157894736842,-0.979406919275124,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","H:Y",16.1625856127882,0.905545449550291,136.210261834263,0.118659089228199,26043.5577250657,1.23987518604392e+26,2.61763817252677,4.4914140361843e-33,32.347616908121,53.6831618314533,Inf,4.58127580776551e-45,"lineage4","dr_mutations_pyrazinamide","ASP",0,"ERR551280","ERR551280","lineage4.4.1.1","sz","Swaziland","pnca_p.his51asp","A","B","HIS","HA51","pnca_complex.pdb"
|
|
"H51D","L4","PZA","H","H51",51,"D",1,"MDR","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",5.661,-1.821,-2.198,4.34022,-1.814,-1.67,82,91,-1.189,9,9,1,0.0044642857142857,"strand",1.36666666666667,6.97,0.0030185424752048,414.608472400514,10454944.8180635,Inf,198.436695636911,16,-28,0,0,-28,0,0,0,0,2,0,2,0,0,0,0,0,4,0,2,2,2,0,4,4,-0.461246200607903,-0.567958656330749,0.158080259908653,-0.309292412617221,-0.43717277486911,0.863157894736842,-0.979406919275124,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","H:Y",16.1625856127882,0.905545449550291,136.210261834263,0.118659089228199,26043.5577250657,1.23987518604392e+26,2.61763817252677,4.4914140361843e-33,32.347616908121,53.6831618314533,Inf,4.58127580776551e-45,"lineage4","dr_mutations_pyrazinamide","ASP",0,"ERR552987","ERR552987","lineage4.4.1.1","sz","Swaziland","pnca_p.his51asp","A","B","HIS","HA51","pnca_complex.pdb"
|
|
"H51D","L2","PZA","H","H51",51,"D",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",5.661,-1.821,-2.198,4.34022,-1.814,-1.67,82,91,-1.189,9,9,1,0.0044642857142857,"strand",1.36666666666667,6.97,0.0030185424752048,414.608472400514,10454944.8180635,Inf,198.436695636911,16,-28,0,0,-28,0,0,0,0,2,0,2,0,0,0,0,0,4,0,2,2,2,0,4,4,-0.461246200607903,-0.567958656330749,0.158080259908653,-0.309292412617221,-0.43717277486911,0.863157894736842,-0.979406919275124,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","H:Y",16.1625856127882,0.905545449550291,136.210261834263,0.118659089228199,26043.5577250657,1.23987518604392e+26,2.61763817252677,4.4914140361843e-33,32.347616908121,53.6831618314533,Inf,4.58127580776551e-45,"lineage2","dr_mutations_pyrazinamide","ASP",0,"ETB0083","SRR6257025","lineage2.2.1","ru","Russia:Altaysky Krai","pnca_p.his51asp","A","B","HIS","HA51","pnca_complex.pdb"
|
|
"H51D","L4","PZA","H","H51",51,"D",1,"MDR","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",5.661,-1.821,-2.198,4.34022,-1.814,-1.67,82,91,-1.189,9,9,1,0.0044642857142857,"strand",1.36666666666667,6.97,0.0030185424752048,414.608472400514,10454944.8180635,Inf,198.436695636911,16,-28,0,0,-28,0,0,0,0,2,0,2,0,0,0,0,0,4,0,2,2,2,0,4,4,-0.461246200607903,-0.567958656330749,0.158080259908653,-0.309292412617221,-0.43717277486911,0.863157894736842,-0.979406919275124,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","H:Y",16.1625856127882,0.905545449550291,136.210261834263,0.118659089228199,26043.5577250657,1.23987518604392e+26,2.61763817252677,4.4914140361843e-33,32.347616908121,53.6831618314533,Inf,4.58127580776551e-45,"lineage4","dr_mutations_pyrazinamide","ASP",0,"ERR551609","ERR551609","lineage4.4.1.1","sz","Swaziland","pnca_p.his51asp","A","B","HIS","HA51","pnca_complex.pdb"
|
|
"H51D","L4","PZA","H","H51",51,"D",1,"MDR","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",5.661,-1.821,-2.198,4.34022,-1.814,-1.67,82,91,-1.189,9,9,1,0.0044642857142857,"strand",1.36666666666667,6.97,0.0030185424752048,414.608472400514,10454944.8180635,Inf,198.436695636911,16,-28,0,0,-28,0,0,0,0,2,0,2,0,0,0,0,0,4,0,2,2,2,0,4,4,-0.461246200607903,-0.567958656330749,0.158080259908653,-0.309292412617221,-0.43717277486911,0.863157894736842,-0.979406919275124,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","H:Y",16.1625856127882,0.905545449550291,136.210261834263,0.118659089228199,26043.5577250657,1.23987518604392e+26,2.61763817252677,4.4914140361843e-33,32.347616908121,53.6831618314533,Inf,4.58127580776551e-45,"lineage4","dr_mutations_pyrazinamide","ASP",0,"ERR552484","ERR552484","lineage4.4.1.1","sz","Swaziland","pnca_p.his51asp","A","B","HIS","HA51","pnca_complex.pdb"
|
|
"H51D","L4","PZA","H","H51",51,"D",1,"MDR","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",5.661,-1.821,-2.198,4.34022,-1.814,-1.67,82,91,-1.189,9,9,1,0.0044642857142857,"strand",1.36666666666667,6.97,0.0030185424752048,414.608472400514,10454944.8180635,Inf,198.436695636911,16,-28,0,0,-28,0,0,0,0,2,0,2,0,0,0,0,0,4,0,2,2,2,0,4,4,-0.461246200607903,-0.567958656330749,0.158080259908653,-0.309292412617221,-0.43717277486911,0.863157894736842,-0.979406919275124,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","H:Y",16.1625856127882,0.905545449550291,136.210261834263,0.118659089228199,26043.5577250657,1.23987518604392e+26,2.61763817252677,4.4914140361843e-33,32.347616908121,53.6831618314533,Inf,4.58127580776551e-45,"lineage4","dr_mutations_pyrazinamide","ASP",0,"ERR552754","ERR552754","lineage4.4.1.1","sz","Swaziland","pnca_p.his51asp","A","B","HIS","HA51","pnca_complex.pdb"
|
|
"H51D","L4","PZA","H","H51",51,"D",1,"MDR","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",5.661,-1.821,-2.198,4.34022,-1.814,-1.67,82,91,-1.189,9,9,1,0.0044642857142857,"strand",1.36666666666667,6.97,0.0030185424752048,414.608472400514,10454944.8180635,Inf,198.436695636911,16,-28,0,0,-28,0,0,0,0,2,0,2,0,0,0,0,0,4,0,2,2,2,0,4,4,-0.461246200607903,-0.567958656330749,0.158080259908653,-0.309292412617221,-0.43717277486911,0.863157894736842,-0.979406919275124,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","H:Y",16.1625856127882,0.905545449550291,136.210261834263,0.118659089228199,26043.5577250657,1.23987518604392e+26,2.61763817252677,4.4914140361843e-33,32.347616908121,53.6831618314533,Inf,4.58127580776551e-45,"lineage4","dr_mutations_pyrazinamide","ASP",0,"ERR553357","ERR553357","lineage4.4.1.1","sz","Swaziland","pnca_p.his51asp","A","B","HIS","HA51","pnca_complex.pdb"
|
|
"H51D","L4","PZA","H","H51",51,"D",1,"MDR","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",5.661,-1.821,-2.198,4.34022,-1.814,-1.67,82,91,-1.189,9,9,1,0.0044642857142857,"strand",1.36666666666667,6.97,0.0030185424752048,414.608472400514,10454944.8180635,Inf,198.436695636911,16,-28,0,0,-28,0,0,0,0,2,0,2,0,0,0,0,0,4,0,2,2,2,0,4,4,-0.461246200607903,-0.567958656330749,0.158080259908653,-0.309292412617221,-0.43717277486911,0.863157894736842,-0.979406919275124,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","H:Y",16.1625856127882,0.905545449550291,136.210261834263,0.118659089228199,26043.5577250657,1.23987518604392e+26,2.61763817252677,4.4914140361843e-33,32.347616908121,53.6831618314533,Inf,4.58127580776551e-45,"lineage4","dr_mutations_pyrazinamide","ASP",0,"ERR552765","ERR552765","lineage4.4.1.1","sz","Swaziland","pnca_p.his51asp","A","B","HIS","HA51","pnca_complex.pdb"
|
|
"H51D","L4","PZA","H","H51",51,"D",1,"MDR","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",5.661,-1.821,-2.198,4.34022,-1.814,-1.67,82,91,-1.189,9,9,1,0.0044642857142857,"strand",1.36666666666667,6.97,0.0030185424752048,414.608472400514,10454944.8180635,Inf,198.436695636911,16,-28,0,0,-28,0,0,0,0,2,0,2,0,0,0,0,0,4,0,2,2,2,0,4,4,-0.461246200607903,-0.567958656330749,0.158080259908653,-0.309292412617221,-0.43717277486911,0.863157894736842,-0.979406919275124,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","H:Y",16.1625856127882,0.905545449550291,136.210261834263,0.118659089228199,26043.5577250657,1.23987518604392e+26,2.61763817252677,4.4914140361843e-33,32.347616908121,53.6831618314533,Inf,4.58127580776551e-45,"lineage4","dr_mutations_pyrazinamide","ASP",0,"ERR552150","ERR552150","lineage4.4.1.1","sz","Swaziland","pnca_p.his51asp","A","B","HIS","HA51","pnca_complex.pdb"
|
|
"H51D","L4","PZA","H","H51",51,"D",1,"MDR","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",5.661,-1.821,-2.198,4.34022,-1.814,-1.67,82,91,-1.189,9,9,1,0.0044642857142857,"strand",1.36666666666667,6.97,0.0030185424752048,414.608472400514,10454944.8180635,Inf,198.436695636911,16,-28,0,0,-28,0,0,0,0,2,0,2,0,0,0,0,0,4,0,2,2,2,0,4,4,-0.461246200607903,-0.567958656330749,0.158080259908653,-0.309292412617221,-0.43717277486911,0.863157894736842,-0.979406919275124,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","H:Y",16.1625856127882,0.905545449550291,136.210261834263,0.118659089228199,26043.5577250657,1.23987518604392e+26,2.61763817252677,4.4914140361843e-33,32.347616908121,53.6831618314533,Inf,4.58127580776551e-45,"lineage4","dr_mutations_pyrazinamide","ASP",0,"ERR552118","ERR552118","lineage4.4.1.1","sz","Swaziland","pnca_p.his51asp","A","B","HIS","HA51","pnca_complex.pdb"
|
|
"H51D","L4","PZA","H","H51",51,"D",1,"MDR","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",5.661,-1.821,-2.198,4.34022,-1.814,-1.67,82,91,-1.189,9,9,1,0.0044642857142857,"strand",1.36666666666667,6.97,0.0030185424752048,414.608472400514,10454944.8180635,Inf,198.436695636911,16,-28,0,0,-28,0,0,0,0,2,0,2,0,0,0,0,0,4,0,2,2,2,0,4,4,-0.461246200607903,-0.567958656330749,0.158080259908653,-0.309292412617221,-0.43717277486911,0.863157894736842,-0.979406919275124,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","H:Y",16.1625856127882,0.905545449550291,136.210261834263,0.118659089228199,26043.5577250657,1.23987518604392e+26,2.61763817252677,4.4914140361843e-33,32.347616908121,53.6831618314533,Inf,4.58127580776551e-45,"lineage4","dr_mutations_pyrazinamide","ASP",0,"ERR552672","ERR552672","lineage4.4.1.1","sz","Swaziland","pnca_p.his51asp","A","B","HIS","HA51","pnca_complex.pdb"
|
|
"H51D","L4","PZA","H","H51",51,"D",1,"MDR","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",5.661,-1.821,-2.198,4.34022,-1.814,-1.67,82,91,-1.189,9,9,1,0.0044642857142857,"strand",1.36666666666667,6.97,0.0030185424752048,414.608472400514,10454944.8180635,Inf,198.436695636911,16,-28,0,0,-28,0,0,0,0,2,0,2,0,0,0,0,0,4,0,2,2,2,0,4,4,-0.461246200607903,-0.567958656330749,0.158080259908653,-0.309292412617221,-0.43717277486911,0.863157894736842,-0.979406919275124,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","H:Y",16.1625856127882,0.905545449550291,136.210261834263,0.118659089228199,26043.5577250657,1.23987518604392e+26,2.61763817252677,4.4914140361843e-33,32.347616908121,53.6831618314533,Inf,4.58127580776551e-45,"lineage4","dr_mutations_pyrazinamide","ASP",0,"ERR551969","ERR551969","lineage4.4.1.1","sz","Swaziland","pnca_p.his51asp","A","B","HIS","HA51","pnca_complex.pdb"
|
|
"H51D","L4","PZA","H","H51",51,"D",1,"MDR","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",5.661,-1.821,-2.198,4.34022,-1.814,-1.67,82,91,-1.189,9,9,1,0.0044642857142857,"strand",1.36666666666667,6.97,0.0030185424752048,414.608472400514,10454944.8180635,Inf,198.436695636911,16,-28,0,0,-28,0,0,0,0,2,0,2,0,0,0,0,0,4,0,2,2,2,0,4,4,-0.461246200607903,-0.567958656330749,0.158080259908653,-0.309292412617221,-0.43717277486911,0.863157894736842,-0.979406919275124,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","H:Y",16.1625856127882,0.905545449550291,136.210261834263,0.118659089228199,26043.5577250657,1.23987518604392e+26,2.61763817252677,4.4914140361843e-33,32.347616908121,53.6831618314533,Inf,4.58127580776551e-45,"lineage4","dr_mutations_pyrazinamide","ASP",0,"ERR552491","ERR552491","lineage4.4.1.1","sz","Swaziland","pnca_p.his51asp","A","B","HIS","HA51","pnca_complex.pdb"
|
|
"H51D","L4","PZA","H","H51",51,"D",1,"MDR","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",5.661,-1.821,-2.198,4.34022,-1.814,-1.67,82,91,-1.189,9,9,1,0.0044642857142857,"strand",1.36666666666667,6.97,0.0030185424752048,414.608472400514,10454944.8180635,Inf,198.436695636911,16,-28,0,0,-28,0,0,0,0,2,0,2,0,0,0,0,0,4,0,2,2,2,0,4,4,-0.461246200607903,-0.567958656330749,0.158080259908653,-0.309292412617221,-0.43717277486911,0.863157894736842,-0.979406919275124,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","H:Y",16.1625856127882,0.905545449550291,136.210261834263,0.118659089228199,26043.5577250657,1.23987518604392e+26,2.61763817252677,4.4914140361843e-33,32.347616908121,53.6831618314533,Inf,4.58127580776551e-45,"lineage4","dr_mutations_pyrazinamide","ASP",0,"ERR553230","ERR553230","lineage4.4.1.1","sz","Swaziland","pnca_p.his51asp","A","B","HIS","HA51","pnca_complex.pdb"
|
|
"H51D","L4","PZA","H","H51",51,"D",1,"MDR","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",5.661,-1.821,-2.198,4.34022,-1.814,-1.67,82,91,-1.189,9,9,1,0.0044642857142857,"strand",1.36666666666667,6.97,0.0030185424752048,414.608472400514,10454944.8180635,Inf,198.436695636911,16,-28,0,0,-28,0,0,0,0,2,0,2,0,0,0,0,0,4,0,2,2,2,0,4,4,-0.461246200607903,-0.567958656330749,0.158080259908653,-0.309292412617221,-0.43717277486911,0.863157894736842,-0.979406919275124,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","H:Y",16.1625856127882,0.905545449550291,136.210261834263,0.118659089228199,26043.5577250657,1.23987518604392e+26,2.61763817252677,4.4914140361843e-33,32.347616908121,53.6831618314533,Inf,4.58127580776551e-45,"lineage4","dr_mutations_pyrazinamide","ASP",0,"ERR552070","ERR552070","lineage4.4.1.1","sz","Swaziland","pnca_p.his51asp","A","B","HIS","HA51","pnca_complex.pdb"
|
|
"H51D","L4","PZA","H","H51",51,"D",1,"MDR","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",5.661,-1.821,-2.198,4.34022,-1.814,-1.67,82,91,-1.189,9,9,1,0.0044642857142857,"strand",1.36666666666667,6.97,0.0030185424752048,414.608472400514,10454944.8180635,Inf,198.436695636911,16,-28,0,0,-28,0,0,0,0,2,0,2,0,0,0,0,0,4,0,2,2,2,0,4,4,-0.461246200607903,-0.567958656330749,0.158080259908653,-0.309292412617221,-0.43717277486911,0.863157894736842,-0.979406919275124,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","H:Y",16.1625856127882,0.905545449550291,136.210261834263,0.118659089228199,26043.5577250657,1.23987518604392e+26,2.61763817252677,4.4914140361843e-33,32.347616908121,53.6831618314533,Inf,4.58127580776551e-45,"lineage4","dr_mutations_pyrazinamide","ASP",0,"ERR552124","ERR552124","lineage4.4.1.1","sz","Swaziland","pnca_p.his51asp","A","B","HIS","HA51","pnca_complex.pdb"
|
|
"H51D","L4","PZA","H","H51",51,"D",1,"MDR","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",5.661,-1.821,-2.198,4.34022,-1.814,-1.67,82,91,-1.189,9,9,1,0.0044642857142857,"strand",1.36666666666667,6.97,0.0030185424752048,414.608472400514,10454944.8180635,Inf,198.436695636911,16,-28,0,0,-28,0,0,0,0,2,0,2,0,0,0,0,0,4,0,2,2,2,0,4,4,-0.461246200607903,-0.567958656330749,0.158080259908653,-0.309292412617221,-0.43717277486911,0.863157894736842,-0.979406919275124,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","H:Y",16.1625856127882,0.905545449550291,136.210261834263,0.118659089228199,26043.5577250657,1.23987518604392e+26,2.61763817252677,4.4914140361843e-33,32.347616908121,53.6831618314533,Inf,4.58127580776551e-45,"lineage4","dr_mutations_pyrazinamide","ASP",0,"ERR552823","ERR552823","lineage4.4.1.1","sz","Swaziland","pnca_p.his51asp","A","B","HIS","HA51","pnca_complex.pdb"
|
|
"H51D","L4","PZA","H","H51",51,"D",1,"MDR","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",5.661,-1.821,-2.198,4.34022,-1.814,-1.67,82,91,-1.189,9,9,1,0.0044642857142857,"strand",1.36666666666667,6.97,0.0030185424752048,414.608472400514,10454944.8180635,Inf,198.436695636911,16,-28,0,0,-28,0,0,0,0,2,0,2,0,0,0,0,0,4,0,2,2,2,0,4,4,-0.461246200607903,-0.567958656330749,0.158080259908653,-0.309292412617221,-0.43717277486911,0.863157894736842,-0.979406919275124,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","H:Y",16.1625856127882,0.905545449550291,136.210261834263,0.118659089228199,26043.5577250657,1.23987518604392e+26,2.61763817252677,4.4914140361843e-33,32.347616908121,53.6831618314533,Inf,4.58127580776551e-45,"lineage4","dr_mutations_pyrazinamide","ASP",0,"ERR550861","ERR550861","lineage4.4.1.1","sz","Swaziland","pnca_p.his51asp","A","B","HIS","HA51","pnca_complex.pdb"
|
|
"H51D","L4","PZA","H","H51",51,"D",1,"MDR","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",5.661,-1.821,-2.198,4.34022,-1.814,-1.67,82,91,-1.189,9,9,1,0.0044642857142857,"strand",1.36666666666667,6.97,0.0030185424752048,414.608472400514,10454944.8180635,Inf,198.436695636911,16,-28,0,0,-28,0,0,0,0,2,0,2,0,0,0,0,0,4,0,2,2,2,0,4,4,-0.461246200607903,-0.567958656330749,0.158080259908653,-0.309292412617221,-0.43717277486911,0.863157894736842,-0.979406919275124,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","H:Y",16.1625856127882,0.905545449550291,136.210261834263,0.118659089228199,26043.5577250657,1.23987518604392e+26,2.61763817252677,4.4914140361843e-33,32.347616908121,53.6831618314533,Inf,4.58127580776551e-45,"lineage4","dr_mutations_pyrazinamide","ASP",0,"ERR552745","ERR552745","lineage4.4.1.1","sz","Swaziland","pnca_p.his51asp","A","B","HIS","HA51","pnca_complex.pdb"
|
|
"H51D","L4","PZA","H","H51",51,"D",1,"MDR","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",5.661,-1.821,-2.198,4.34022,-1.814,-1.67,82,91,-1.189,9,9,1,0.0044642857142857,"strand",1.36666666666667,6.97,0.0030185424752048,414.608472400514,10454944.8180635,Inf,198.436695636911,16,-28,0,0,-28,0,0,0,0,2,0,2,0,0,0,0,0,4,0,2,2,2,0,4,4,-0.461246200607903,-0.567958656330749,0.158080259908653,-0.309292412617221,-0.43717277486911,0.863157894736842,-0.979406919275124,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","H:Y",16.1625856127882,0.905545449550291,136.210261834263,0.118659089228199,26043.5577250657,1.23987518604392e+26,2.61763817252677,4.4914140361843e-33,32.347616908121,53.6831618314533,Inf,4.58127580776551e-45,"lineage4","dr_mutations_pyrazinamide","ASP",0,"SAMN02053803","SRR833097_SRR833080","lineage4.3.3","za","South Africa","pnca_p.his51asp","A","B","HIS","HA51","pnca_complex.pdb"
|
|
"H51D","L4","PZA","H","H51",51,"D",1,"MDR","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",5.661,-1.821,-2.198,4.34022,-1.814,-1.67,82,91,-1.189,9,9,1,0.0044642857142857,"strand",1.36666666666667,6.97,0.0030185424752048,414.608472400514,10454944.8180635,Inf,198.436695636911,16,-28,0,0,-28,0,0,0,0,2,0,2,0,0,0,0,0,4,0,2,2,2,0,4,4,-0.461246200607903,-0.567958656330749,0.158080259908653,-0.309292412617221,-0.43717277486911,0.863157894736842,-0.979406919275124,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","H:Y",16.1625856127882,0.905545449550291,136.210261834263,0.118659089228199,26043.5577250657,1.23987518604392e+26,2.61763817252677,4.4914140361843e-33,32.347616908121,53.6831618314533,Inf,4.58127580776551e-45,"lineage4","dr_mutations_pyrazinamide","ASP",0,"ERR552077","ERR552077","lineage4.4.1.1","sz","Swaziland","pnca_p.his51asp","A","B","HIS","HA51","pnca_complex.pdb"
|
|
"H51D","L4","PZA","H","H51",51,"D",1,"MDR","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",5.661,-1.821,-2.198,4.34022,-1.814,-1.67,82,91,-1.189,9,9,1,0.0044642857142857,"strand",1.36666666666667,6.97,0.0030185424752048,414.608472400514,10454944.8180635,Inf,198.436695636911,16,-28,0,0,-28,0,0,0,0,2,0,2,0,0,0,0,0,4,0,2,2,2,0,4,4,-0.461246200607903,-0.567958656330749,0.158080259908653,-0.309292412617221,-0.43717277486911,0.863157894736842,-0.979406919275124,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","H:Y",16.1625856127882,0.905545449550291,136.210261834263,0.118659089228199,26043.5577250657,1.23987518604392e+26,2.61763817252677,4.4914140361843e-33,32.347616908121,53.6831618314533,Inf,4.58127580776551e-45,"lineage4","dr_mutations_pyrazinamide","ASP",0,"ERR553242","ERR553242","lineage4.4.1.1","sz","Swaziland","pnca_p.his51asp","A","B","HIS","HA51","pnca_complex.pdb"
|
|
"H51D","L4","PZA","H","H51",51,"D",1,"MDR","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",5.661,-1.821,-2.198,4.34022,-1.814,-1.67,82,91,-1.189,9,9,1,0.0044642857142857,"strand",1.36666666666667,6.97,0.0030185424752048,414.608472400514,10454944.8180635,Inf,198.436695636911,16,-28,0,0,-28,0,0,0,0,2,0,2,0,0,0,0,0,4,0,2,2,2,0,4,4,-0.461246200607903,-0.567958656330749,0.158080259908653,-0.309292412617221,-0.43717277486911,0.863157894736842,-0.979406919275124,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","H:Y",16.1625856127882,0.905545449550291,136.210261834263,0.118659089228199,26043.5577250657,1.23987518604392e+26,2.61763817252677,4.4914140361843e-33,32.347616908121,53.6831618314533,Inf,4.58127580776551e-45,"lineage4","dr_mutations_pyrazinamide","ASP",0,"ERR552496","ERR552496","lineage4.4.1.1","sz","Swaziland","pnca_p.his51asp","A","B","HIS","HA51","pnca_complex.pdb"
|
|
"H51D","L4","PZA","H","H51",51,"D",NA,"MDR","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",5.661,-1.821,-2.198,4.34022,-1.814,-1.67,82,91,-1.189,9,9,1,0.0044642857142857,"strand",1.36666666666667,6.97,0.0030185424752048,414.608472400514,10454944.8180635,Inf,198.436695636911,16,-28,0,0,-28,0,0,0,0,2,0,2,0,0,0,0,0,4,0,2,2,2,0,4,4,-0.461246200607903,-0.567958656330749,0.158080259908653,-0.309292412617221,-0.43717277486911,0.863157894736842,-0.979406919275124,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","H:Y",16.1625856127882,0.905545449550291,136.210261834263,0.118659089228199,26043.5577250657,1.23987518604392e+26,2.61763817252677,4.4914140361843e-33,32.347616908121,53.6831618314533,Inf,4.58127580776551e-45,"lineage4","dr_mutations_pyrazinamide","ASP",0,"ERR3275811","ERR3275811","lineage4.1.2.1","nl","Netherlands","pnca_p.his51asp","A","B","HIS","HA51","pnca_complex.pdb"
|
|
"H51D","L4","PZA","H","H51",51,"D",NA,"XDR","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",5.661,-1.821,-2.198,4.34022,-1.814,-1.67,82,91,-1.189,9,9,1,0.0044642857142857,"strand",1.36666666666667,6.97,0.0030185424752048,414.608472400514,10454944.8180635,Inf,198.436695636911,16,-28,0,0,-28,0,0,0,0,2,0,2,0,0,0,0,0,4,0,2,2,2,0,4,4,-0.461246200607903,-0.567958656330749,0.158080259908653,-0.309292412617221,-0.43717277486911,0.863157894736842,-0.979406919275124,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","H:Y",16.1625856127882,0.905545449550291,136.210261834263,0.118659089228199,26043.5577250657,1.23987518604392e+26,2.61763817252677,4.4914140361843e-33,32.347616908121,53.6831618314533,Inf,4.58127580776551e-45,"lineage4","dr_mutations_pyrazinamide","ASP",0,"SAMN02403625","SRR1181062_SRR1180998","lineage4.4.1.1","sz","Swaziland","pnca_p.his51asp","A","B","HIS","HA51","pnca_complex.pdb"
|
|
"H51D","L4","PZA","H","H51",51,"D",1,"MDR","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",5.661,-1.821,-2.198,4.34022,-1.814,-1.67,82,91,-1.189,9,9,1,0.0044642857142857,"strand",1.36666666666667,6.97,0.0030185424752048,414.608472400514,10454944.8180635,Inf,198.436695636911,16,-28,0,0,-28,0,0,0,0,2,0,2,0,0,0,0,0,4,0,2,2,2,0,4,4,-0.461246200607903,-0.567958656330749,0.158080259908653,-0.309292412617221,-0.43717277486911,0.863157894736842,-0.979406919275124,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","H:Y",16.1625856127882,0.905545449550291,136.210261834263,0.118659089228199,26043.5577250657,1.23987518604392e+26,2.61763817252677,4.4914140361843e-33,32.347616908121,53.6831618314533,Inf,4.58127580776551e-45,"lineage4","dr_mutations_pyrazinamide","ASP",0,"SAMN02053806","SRR833048_SRR833177","lineage4.3.3","za","South Africa","pnca_p.his51asp","A","B","HIS","HA51","pnca_complex.pdb"
|
|
"H51D","L4","PZA","H","H51",51,"D",1,"MDR","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",5.661,-1.821,-2.198,4.34022,-1.814,-1.67,82,91,-1.189,9,9,1,0.0044642857142857,"strand",1.36666666666667,6.97,0.0030185424752048,414.608472400514,10454944.8180635,Inf,198.436695636911,16,-28,0,0,-28,0,0,0,0,2,0,2,0,0,0,0,0,4,0,2,2,2,0,4,4,-0.461246200607903,-0.567958656330749,0.158080259908653,-0.309292412617221,-0.43717277486911,0.863157894736842,-0.979406919275124,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","H:Y",16.1625856127882,0.905545449550291,136.210261834263,0.118659089228199,26043.5577250657,1.23987518604392e+26,2.61763817252677,4.4914140361843e-33,32.347616908121,53.6831618314533,Inf,4.58127580776551e-45,"lineage4","dr_mutations_pyrazinamide","ASP",0,"ERR552870","ERR552870","lineage4.4.1.1","sz","Swaziland","pnca_p.his51asp","A","B","HIS","HA51","pnca_complex.pdb"
|
|
"H51D","L4","PZA","H","H51",51,"D",1,"MDR","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",5.661,-1.821,-2.198,4.34022,-1.814,-1.67,82,91,-1.189,9,9,1,0.0044642857142857,"strand",1.36666666666667,6.97,0.0030185424752048,414.608472400514,10454944.8180635,Inf,198.436695636911,16,-28,0,0,-28,0,0,0,0,2,0,2,0,0,0,0,0,4,0,2,2,2,0,4,4,-0.461246200607903,-0.567958656330749,0.158080259908653,-0.309292412617221,-0.43717277486911,0.863157894736842,-0.979406919275124,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","H:Y",16.1625856127882,0.905545449550291,136.210261834263,0.118659089228199,26043.5577250657,1.23987518604392e+26,2.61763817252677,4.4914140361843e-33,32.347616908121,53.6831618314533,Inf,4.58127580776551e-45,"lineage4","dr_mutations_pyrazinamide","ASP",0,"ERR552612","ERR552612","lineage4.4.1.1","sz","Swaziland","pnca_p.his51asp","A","B","HIS","HA51","pnca_complex.pdb"
|
|
"H51D","L4","PZA","H","H51",51,"D",1,"MDR","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",5.661,-1.821,-2.198,4.34022,-1.814,-1.67,82,91,-1.189,9,9,1,0.0044642857142857,"strand",1.36666666666667,6.97,0.0030185424752048,414.608472400514,10454944.8180635,Inf,198.436695636911,16,-28,0,0,-28,0,0,0,0,2,0,2,0,0,0,0,0,4,0,2,2,2,0,4,4,-0.461246200607903,-0.567958656330749,0.158080259908653,-0.309292412617221,-0.43717277486911,0.863157894736842,-0.979406919275124,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","H:Y",16.1625856127882,0.905545449550291,136.210261834263,0.118659089228199,26043.5577250657,1.23987518604392e+26,2.61763817252677,4.4914140361843e-33,32.347616908121,53.6831618314533,Inf,4.58127580776551e-45,"lineage4","dr_mutations_pyrazinamide","ASP",0,"ERR552822","ERR552822","lineage4.4.1.1","sz","Swaziland","pnca_p.his51asp","A","B","HIS","HA51","pnca_complex.pdb"
|
|
"H51D","L4","PZA","H","H51",51,"D",1,"MDR","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",5.661,-1.821,-2.198,4.34022,-1.814,-1.67,82,91,-1.189,9,9,1,0.0044642857142857,"strand",1.36666666666667,6.97,0.0030185424752048,414.608472400514,10454944.8180635,Inf,198.436695636911,16,-28,0,0,-28,0,0,0,0,2,0,2,0,0,0,0,0,4,0,2,2,2,0,4,4,-0.461246200607903,-0.567958656330749,0.158080259908653,-0.309292412617221,-0.43717277486911,0.863157894736842,-0.979406919275124,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","H:Y",16.1625856127882,0.905545449550291,136.210261834263,0.118659089228199,26043.5577250657,1.23987518604392e+26,2.61763817252677,4.4914140361843e-33,32.347616908121,53.6831618314533,Inf,4.58127580776551e-45,"lineage4","dr_mutations_pyrazinamide","ASP",0,"ERR551014","ERR551014","lineage4.4.1.1","sz","Swaziland","pnca_p.his51asp","A","B","HIS","HA51","pnca_complex.pdb"
|
|
"H51D","L4","PZA","H","H51",51,"D",1,"MDR","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",5.661,-1.821,-2.198,4.34022,-1.814,-1.67,82,91,-1.189,9,9,1,0.0044642857142857,"strand",1.36666666666667,6.97,0.0030185424752048,414.608472400514,10454944.8180635,Inf,198.436695636911,16,-28,0,0,-28,0,0,0,0,2,0,2,0,0,0,0,0,4,0,2,2,2,0,4,4,-0.461246200607903,-0.567958656330749,0.158080259908653,-0.309292412617221,-0.43717277486911,0.863157894736842,-0.979406919275124,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","H:Y",16.1625856127882,0.905545449550291,136.210261834263,0.118659089228199,26043.5577250657,1.23987518604392e+26,2.61763817252677,4.4914140361843e-33,32.347616908121,53.6831618314533,Inf,4.58127580776551e-45,"lineage4","dr_mutations_pyrazinamide","ASP",0,"ERR551488","ERR551488","lineage4.4.1.1","sz","Swaziland","pnca_p.his51asp","A","B","HIS","HA51","pnca_complex.pdb"
|
|
"H51N","L4","PZA","H","H51",51,"N",NA,"MDR","DM","hydrophobic","hydrophilic","basic","neutral","pos","polar",5.661,-1.063,-2.215,1.03208,-2.201,-1.83,70,85,-1.189,9,9,1,0.0044642857142857,"strand",1.36666666666667,6.97,NA,NA,NA,NA,NA,14,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-4,0,2,0,-0.269250253292806,-0.57235142118863,0.0375906001646282,-0.375277067348679,-0.479057591623037,0.736842105263158,-0.979406919275124,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","H:Y",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage4","dr_mutations_pyrazinamide","ASN",0,"ERR2516444","ERR2516444","lineage4.1.2.1","nl","Netherlands","pnca_p.his51asn","A","B","HIS","HA51","pnca_complex.pdb"
|
|
"H51P","L2","PZA","H","H51",51,"P",1,"Pre-XDR","DM","hydrophobic","hydrophilic","basic","non-polar","pos","non-polar",5.661,-2.624,-1.762,2.82591,-1.529,-0.98,82,91,-1.189,9,9,1,0.0044642857142857,"strand",1.36666666666667,6.97,0.0002156101768003,2.42493692178301,2.42493957425811,2.42473736947533,4.31445715363782e-25,28,0,0,0,0,0,0,0,0,4,2,2,0,0,0,0,0,0,0,-2,2,4,0,6,2,-0.664640324214792,-0.455297157622739,0.10292579345712,-0.260699062233589,-0.256544502617801,0.863157894736842,-0.979406919275124,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","H:Y",0.885806606247285,0.469406216824825,1.22442753211922,0.723445514749364,0.112662937620387,25.3270547471172,0.384700446081433,0.430258985168156,0.366270051463612,0.0410854444106247,46.5881472867033,0.999999999999476,"lineage2","dr_mutations_pyrazinamide","PRO",0,"0111X-sc-2012-10-11T13:37:09Z-1494123,ERR234637","ERR234637","lineage2.2.1","ru","Russia,Samara","pnca_p.his51pro","A","B","HIS","HA51","pnca_complex.pdb"
|
|
"H51P","L4","PZA","H","H51",51,"P",NA,"MDR","DM","hydrophobic","hydrophilic","basic","non-polar","pos","non-polar",5.661,-2.624,-1.762,2.82591,-1.529,-0.98,82,91,-1.189,9,9,1,0.0044642857142857,"strand",1.36666666666667,6.97,0.0002156101768003,2.42493692178301,2.42493957425811,2.42473736947533,4.31445715363782e-25,28,0,0,0,0,0,0,0,0,4,2,2,0,0,0,0,0,0,0,-2,2,4,0,6,2,-0.664640324214792,-0.455297157622739,0.10292579345712,-0.260699062233589,-0.256544502617801,0.863157894736842,-0.979406919275124,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","H:Y",0.885806606247285,0.469406216824825,1.22442753211922,0.723445514749364,0.112662937620387,25.3270547471172,0.384700446081433,0.430258985168156,0.366270051463612,0.0410854444106247,46.5881472867033,0.999999999999476,"lineage4","dr_mutations_pyrazinamide","PRO",0,"SRR5818595","SRR5818595","lineage4.2.2","dj","Djibouti","pnca_p.his51pro","A","B","HIS","HA51","pnca_complex.pdb"
|
|
"H51P","L4","PZA","H","H51",51,"P",NA,"MDR","DM","hydrophobic","hydrophilic","basic","non-polar","pos","non-polar",5.661,-2.624,-1.762,2.82591,-1.529,-0.98,82,91,-1.189,9,9,1,0.0044642857142857,"strand",1.36666666666667,6.97,0.0002156101768003,2.42493692178301,2.42493957425811,2.42473736947533,4.31445715363782e-25,28,0,0,0,0,0,0,0,0,4,2,2,0,0,0,0,0,0,0,-2,2,4,0,6,2,-0.664640324214792,-0.455297157622739,0.10292579345712,-0.260699062233589,-0.256544502617801,0.863157894736842,-0.979406919275124,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","H:Y",0.885806606247285,0.469406216824825,1.22442753211922,0.723445514749364,0.112662937620387,25.3270547471172,0.384700446081433,0.430258985168156,0.366270051463612,0.0410854444106247,46.5881472867033,0.999999999999476,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR2707187","ERR2707187","lineage4.3.4.1","cd","Democratic Republic of Congo","pnca_p.his51pro","A","B","HIS","HA51","pnca_complex.pdb"
|
|
"H51P","L2","PZA","H","H51",51,"P",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","basic","non-polar","pos","non-polar",5.661,-2.624,-1.762,2.82591,-1.529,-0.98,82,91,-1.189,9,9,1,0.0044642857142857,"strand",1.36666666666667,6.97,0.0002156101768003,2.42493692178301,2.42493957425811,2.42473736947533,4.31445715363782e-25,28,0,0,0,0,0,0,0,0,4,2,2,0,0,0,0,0,0,0,-2,2,4,0,6,2,-0.664640324214792,-0.455297157622739,0.10292579345712,-0.260699062233589,-0.256544502617801,0.863157894736842,-0.979406919275124,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","H:Y",0.885806606247285,0.469406216824825,1.22442753211922,0.723445514749364,0.112662937620387,25.3270547471172,0.384700446081433,0.430258985168156,0.366270051463612,0.0410854444106247,46.5881472867033,0.999999999999476,"lineage2","dr_mutations_pyrazinamide","PRO",0,"SRR5710014,SAMN07236287","SRR5710014","lineage2.2.1","th","Thailand","pnca_p.his51pro","A","B","HIS","HA51","pnca_complex.pdb"
|
|
"H51P","L2","PZA","H","H51",51,"P",NA,"XDR","DM","hydrophobic","hydrophilic","basic","non-polar","pos","non-polar",5.661,-2.624,-1.762,2.82591,-1.529,-0.98,82,91,-1.189,9,9,1,0.0044642857142857,"strand",1.36666666666667,6.97,0.0002156101768003,2.42493692178301,2.42493957425811,2.42473736947533,4.31445715363782e-25,28,0,0,0,0,0,0,0,0,4,2,2,0,0,0,0,0,0,0,-2,2,4,0,6,2,-0.664640324214792,-0.455297157622739,0.10292579345712,-0.260699062233589,-0.256544502617801,0.863157894736842,-0.979406919275124,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","H:Y",0.885806606247285,0.469406216824825,1.22442753211922,0.723445514749364,0.112662937620387,25.3270547471172,0.384700446081433,0.430258985168156,0.366270051463612,0.0410854444106247,46.5881472867033,0.999999999999476,"lineage2","dr_mutations_pyrazinamide","PRO",0,"ERR234601","ERR234601","lineage2.2.1","ru","Russia","pnca_p.his51pro","A","B","HIS","HA51","pnca_complex.pdb"
|
|
"H51P","L2","PZA","H","H51",51,"P",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","basic","non-polar","pos","non-polar",5.661,-2.624,-1.762,2.82591,-1.529,-0.98,82,91,-1.189,9,9,1,0.0044642857142857,"strand",1.36666666666667,6.97,0.0002156101768003,2.42493692178301,2.42493957425811,2.42473736947533,4.31445715363782e-25,28,0,0,0,0,0,0,0,0,4,2,2,0,0,0,0,0,0,0,-2,2,4,0,6,2,-0.664640324214792,-0.455297157622739,0.10292579345712,-0.260699062233589,-0.256544502617801,0.863157894736842,-0.979406919275124,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","H:Y",0.885806606247285,0.469406216824825,1.22442753211922,0.723445514749364,0.112662937620387,25.3270547471172,0.384700446081433,0.430258985168156,0.366270051463612,0.0410854444106247,46.5881472867033,0.999999999999476,"lineage2","dr_mutations_pyrazinamide","PRO",0,"SAMN07236270,SRR5709756","SRR5709756","lineage2.2.1","th","Thailand","pnca_p.his51pro","A","B","HIS","HA51","pnca_complex.pdb"
|
|
"H51P","L4","PZA","H","H51",51,"P",NA,"MDR","DM","hydrophobic","hydrophilic","basic","non-polar","pos","non-polar",5.661,-2.624,-1.762,2.82591,-1.529,-0.98,82,91,-1.189,9,9,1,0.0044642857142857,"strand",1.36666666666667,6.97,0.0002156101768003,2.42493692178301,2.42493957425811,2.42473736947533,4.31445715363782e-25,28,0,0,0,0,0,0,0,0,4,2,2,0,0,0,0,0,0,0,-2,2,4,0,6,2,-0.664640324214792,-0.455297157622739,0.10292579345712,-0.260699062233589,-0.256544502617801,0.863157894736842,-0.979406919275124,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","H:Y",0.885806606247285,0.469406216824825,1.22442753211922,0.723445514749364,0.112662937620387,25.3270547471172,0.384700446081433,0.430258985168156,0.366270051463612,0.0410854444106247,46.5881472867033,0.999999999999476,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR2707228","ERR2707228","lineage4.3.3","cd","Democratic Republic of Congo","pnca_p.his51pro","A","B","HIS","HA51","pnca_complex.pdb"
|
|
"H51P","L2","PZA","H","H51",51,"P",0,"MDR","DM","hydrophobic","hydrophilic","basic","non-polar","pos","non-polar",5.661,-2.624,-1.762,2.82591,-1.529,-0.98,82,91,-1.189,9,9,1,0.0044642857142857,"strand",1.36666666666667,6.97,0.0002156101768003,2.42493692178301,2.42493957425811,2.42473736947533,4.31445715363782e-25,28,0,0,0,0,0,0,0,0,4,2,2,0,0,0,0,0,0,0,-2,2,4,0,6,2,-0.664640324214792,-0.455297157622739,0.10292579345712,-0.260699062233589,-0.256544502617801,0.863157894736842,-0.979406919275124,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","H:Y",0.885806606247285,0.469406216824825,1.22442753211922,0.723445514749364,0.112662937620387,25.3270547471172,0.384700446081433,0.430258985168156,0.366270051463612,0.0410854444106247,46.5881472867033,0.999999999999476,"lineage2","dr_mutations_pyrazinamide","PRO",0,"ERS457187","ERR551221_ERR551220","lineage2.2.1","uz","Nukus","pnca_p.his51pro","A","B","HIS","HA51","pnca_complex.pdb"
|
|
"H51P","L2","PZA","H","H51",51,"P",0,"XDR","DM","hydrophobic","hydrophilic","basic","non-polar","pos","non-polar",5.661,-2.624,-1.762,2.82591,-1.529,-0.98,82,91,-1.189,9,9,1,0.0044642857142857,"strand",1.36666666666667,6.97,0.0002156101768003,2.42493692178301,2.42493957425811,2.42473736947533,4.31445715363782e-25,28,0,0,0,0,0,0,0,0,4,2,2,0,0,0,0,0,0,0,-2,2,4,0,6,2,-0.664640324214792,-0.455297157622739,0.10292579345712,-0.260699062233589,-0.256544502617801,0.863157894736842,-0.979406919275124,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","H:Y",0.885806606247285,0.469406216824825,1.22442753211922,0.723445514749364,0.112662937620387,25.3270547471172,0.384700446081433,0.430258985168156,0.366270051463612,0.0410854444106247,46.5881472867033,0.999999999999476,"lineage2","dr_mutations_pyrazinamide","PRO",0,"1392P-sc-2012-02-21T11:36:36Z-1364715,ERR137223","ERR137223","lineage2.2.1","ru","Russia,Samara","pnca_p.his51pro","A","B","HIS","HA51","pnca_complex.pdb"
|
|
"H51P","L4","PZA","H","H51",51,"P",NA,"XDR","DM","hydrophobic","hydrophilic","basic","non-polar","pos","non-polar",5.661,-2.624,-1.762,2.82591,-1.529,-0.98,82,91,-1.189,9,9,1,0.0044642857142857,"strand",1.36666666666667,6.97,0.0002156101768003,2.42493692178301,2.42493957425811,2.42473736947533,4.31445715363782e-25,28,0,0,0,0,0,0,0,0,4,2,2,0,0,0,0,0,0,0,-2,2,4,0,6,2,-0.664640324214792,-0.455297157622739,0.10292579345712,-0.260699062233589,-0.256544502617801,0.863157894736842,-0.979406919275124,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","H:Y",0.885806606247285,0.469406216824825,1.22442753211922,0.723445514749364,0.112662937620387,25.3270547471172,0.384700446081433,0.430258985168156,0.366270051463612,0.0410854444106247,46.5881472867033,0.999999999999476,"lineage4","dr_mutations_pyrazinamide","PRO",0,"SRR5266558","SRR5266558","lineage4.3.3","ru","Russia","pnca_p.his51pro","A","B","HIS","HA51","pnca_complex.pdb"
|
|
"H51Q","L2","PZA","H","H51",51,"Q",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","basic","neutral","pos","polar",5.661,-1.42,-1.714,-1.10489,-1.18,-1.75,65,80,-1.189,9,9,1,0.0044642857142857,"strand",1.36666666666667,6.97,0.0004312203536006,24.2923336141533,24.29233342416,24.2833096922897,14.1977442691074,0,0,0,0,0,0,0,0,0,-4,0,-2,-2,0,0,0,0,2,0,2,0,-6,0,-2,-4,-0.3596757852077,-0.442894056847545,-0.212429823886795,-0.201193520886615,-0.458115183246073,0.684210526315789,-0.979406919275124,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","H:Y",3.19016080361872,0.0035954281300595,1.09565968954934,2.91163472932995,3.91551977432275,465.531063220863,1.38546923679232,0.0007494070007895,3.12528225414311,2.71567844828345,1141.60089496884,0.0001645676755807,"lineage2","dr_mutations_pyrazinamide","GLN",0,"SRS935961,SAMN03653227","SRR2024921","lineage2.2.1","cn","China","pnca_p.his51gln","A","B","HIS","HA51","pnca_complex.pdb"
|
|
"H51Q","L3","PZA","H","H51",51,"Q",1,"Pre-XDR","DM","hydrophobic","hydrophilic","basic","neutral","pos","polar",5.661,-1.42,-1.714,-1.10489,-1.18,-1.75,65,80,-1.189,9,9,1,0.0044642857142857,"strand",1.36666666666667,6.97,0.0004312203536006,24.2923336141533,24.29233342416,24.2833096922897,14.1977442691074,0,0,0,0,0,0,0,0,0,-4,0,-2,-2,0,0,0,0,2,0,2,0,-6,0,-2,-4,-0.3596757852077,-0.442894056847545,-0.212429823886795,-0.201193520886615,-0.458115183246073,0.684210526315789,-0.979406919275124,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","H:Y",3.19016080361872,0.0035954281300595,1.09565968954934,2.91163472932995,3.91551977432275,465.531063220863,1.38546923679232,0.0007494070007895,3.12528225414311,2.71567844828345,1141.60089496884,0.0001645676755807,"lineage3","dr_mutations_pyrazinamide","GLN",0,"ERR2510560","ERR2510560","lineage3","pk","Pakistan","pnca_p.his51gln","A","B","HIS","HA51","pnca_complex.pdb"
|
|
"H51Q","L2","PZA","H","H51",51,"Q",NA,"MDR","DM","hydrophobic","hydrophilic","basic","neutral","pos","polar",5.661,-1.42,-1.714,-1.10489,-1.18,-1.75,65,80,-1.189,9,9,1,0.0044642857142857,"strand",1.36666666666667,6.97,0.0004312203536006,24.2923336141533,24.29233342416,24.2833096922897,14.1977442691074,0,0,0,0,0,0,0,0,0,-4,0,-2,-2,0,0,0,0,2,0,2,0,-6,0,-2,-4,-0.3596757852077,-0.442894056847545,-0.212429823886795,-0.201193520886615,-0.458115183246073,0.684210526315789,-0.979406919275124,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","H:Y",3.19016080361872,0.0035954281300595,1.09565968954934,2.91163472932995,3.91551977432275,465.531063220863,1.38546923679232,0.0007494070007895,3.12528225414311,2.71567844828345,1141.60089496884,0.0001645676755807,"lineage2","dr_mutations_pyrazinamide","GLN",0,"ERR751453","ERR751453","lineage2.2.1","pe","","pnca_p.his51gln","A","B","HIS","HA51","pnca_complex.pdb"
|
|
"H51Q","L4","PZA","H","H51",51,"Q",1,"Other","DM","hydrophobic","hydrophilic","basic","neutral","pos","polar",5.661,-1.42,-1.714,-1.10489,-1.18,-1.75,65,80,-1.189,9,9,1,0.0044642857142857,"strand",1.36666666666667,6.97,0.0004312203536006,24.2923336141533,24.29233342416,24.2833096922897,14.1977442691074,0,0,0,0,0,0,0,0,0,-4,0,-2,-2,0,0,0,0,2,0,2,0,-6,0,-2,-4,-0.3596757852077,-0.442894056847545,-0.212429823886795,-0.201193520886615,-0.458115183246073,0.684210526315789,-0.979406919275124,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","H:Y",3.19016080361872,0.0035954281300595,1.09565968954934,2.91163472932995,3.91551977432275,465.531063220863,1.38546923679232,0.0007494070007895,3.12528225414311,2.71567844828345,1141.60089496884,0.0001645676755807,"lineage4","dr_mutations_pyrazinamide","GLN",0,"2326E-sc-2012-10-11T13:38:08Z-1494185,ERR228021","ERR228021","lineage4.1.2","ru","Russia,unknown","pnca_p.his51gln","A","B","HIS","HA51","pnca_complex.pdb"
|
|
"H51Q","L3","PZA","H","H51",51,"Q",1,"MDR","DM","hydrophobic","hydrophilic","basic","neutral","pos","polar",5.661,-1.42,-1.714,-1.10489,-1.18,-1.75,65,80,-1.189,9,9,1,0.0044642857142857,"strand",1.36666666666667,6.97,0.0004312203536006,24.2923336141533,24.29233342416,24.2833096922897,14.1977442691074,0,0,0,0,0,0,0,0,0,-4,0,-2,-2,0,0,0,0,2,0,2,0,-6,0,-2,-4,-0.3596757852077,-0.442894056847545,-0.212429823886795,-0.201193520886615,-0.458115183246073,0.684210526315789,-0.979406919275124,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","H:Y",3.19016080361872,0.0035954281300595,1.09565968954934,2.91163472932995,3.91551977432275,465.531063220863,1.38546923679232,0.0007494070007895,3.12528225414311,2.71567844828345,1141.60089496884,0.0001645676755807,"lineage3","dr_mutations_pyrazinamide","GLN",0,"ERS2592783","ERR2677437","lineage3.1","de","Germany","pnca_p.his51gln","A","B","HIS","HA51","pnca_complex.pdb"
|
|
"H51Q","L3","PZA","H","H51",51,"Q",1,"MDR","DM","hydrophobic","hydrophilic","basic","neutral","pos","polar",5.661,-1.42,-1.714,-1.10489,-1.18,-1.75,65,80,-1.189,9,9,1,0.0044642857142857,"strand",1.36666666666667,6.97,0.0004312203536006,24.2923336141533,24.29233342416,24.2833096922897,14.1977442691074,0,0,0,0,0,0,0,0,0,-4,0,-2,-2,0,0,0,0,2,0,2,0,-6,0,-2,-4,-0.3596757852077,-0.442894056847545,-0.212429823886795,-0.201193520886615,-0.458115183246073,0.684210526315789,-0.979406919275124,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","H:Y",3.19016080361872,0.0035954281300595,1.09565968954934,2.91163472932995,3.91551977432275,465.531063220863,1.38546923679232,0.0007494070007895,3.12528225414311,2.71567844828345,1141.60089496884,0.0001645676755807,"lineage3","dr_mutations_pyrazinamide","GLN",0,"ERS2592780","ERR2677434","lineage3.1","de","Germany","pnca_p.his51gln","A","B","HIS","HA51","pnca_complex.pdb"
|
|
"H51Q","L4","PZA","H","H51",51,"Q",1,"Other","DM","hydrophobic","hydrophilic","basic","neutral","pos","polar",5.661,-1.42,-1.714,-1.10489,-1.18,-1.75,65,80,-1.189,9,9,1,0.0044642857142857,"strand",1.36666666666667,6.97,0.0004312203536006,24.2923336141533,24.29233342416,24.2833096922897,14.1977442691074,0,0,0,0,0,0,0,0,0,-4,0,-2,-2,0,0,0,0,2,0,2,0,-6,0,-2,-4,-0.3596757852077,-0.442894056847545,-0.212429823886795,-0.201193520886615,-0.458115183246073,0.684210526315789,-0.979406919275124,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","H:Y",3.19016080361872,0.0035954281300595,1.09565968954934,2.91163472932995,3.91551977432275,465.531063220863,1.38546923679232,0.0007494070007895,3.12528225414311,2.71567844828345,1141.60089496884,0.0001645676755807,"lineage4","dr_mutations_pyrazinamide","GLN",0,"SAMN03648604,SRR2101357","SRR2101357","lineage4.1.2","","","pnca_p.his51gln","A","B","HIS","HA51","pnca_complex.pdb"
|
|
"H51Q","L4","PZA","H","H51",51,"Q",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","basic","neutral","pos","polar",5.661,-1.42,-1.714,-1.10489,-1.18,-1.75,65,80,-1.189,9,9,1,0.0044642857142857,"strand",1.36666666666667,6.97,0.0004312203536006,24.2923336141533,24.29233342416,24.2833096922897,14.1977442691074,0,0,0,0,0,0,0,0,0,-4,0,-2,-2,0,0,0,0,2,0,2,0,-6,0,-2,-4,-0.3596757852077,-0.442894056847545,-0.212429823886795,-0.201193520886615,-0.458115183246073,0.684210526315789,-0.979406919275124,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","H:Y",3.19016080361872,0.0035954281300595,1.09565968954934,2.91163472932995,3.91551977432275,465.531063220863,1.38546923679232,0.0007494070007895,3.12528225414311,2.71567844828345,1141.60089496884,0.0001645676755807,"lineage4","dr_mutations_pyrazinamide","GLN",0,"ERR2515590","ERR2515590","lineage4.1.2","za","South Africa","pnca_p.his51gln","A","B","HIS","HA51","pnca_complex.pdb"
|
|
"H51Q","L4","PZA","H","H51",51,"Q",0,"Other","DM","hydrophobic","hydrophilic","basic","neutral","pos","polar",5.661,-1.42,-1.714,-1.10489,-1.18,-1.75,65,80,-1.189,9,9,1,0.0044642857142857,"strand",1.36666666666667,6.97,0.0004312203536006,24.2923336141533,24.29233342416,24.2833096922897,14.1977442691074,0,0,0,0,0,0,0,0,0,-4,0,-2,-2,0,0,0,0,2,0,2,0,-6,0,-2,-4,-0.3596757852077,-0.442894056847545,-0.212429823886795,-0.201193520886615,-0.458115183246073,0.684210526315789,-0.979406919275124,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","H:Y",3.19016080361872,0.0035954281300595,1.09565968954934,2.91163472932995,3.91551977432275,465.531063220863,1.38546923679232,0.0007494070007895,3.12528225414311,2.71567844828345,1141.60089496884,0.0001645676755807,"lineage4","dr_mutations_pyrazinamide","GLN",0,"SRR2101370,SAMN03648617","SRR2101370","lineage4.1.2","","","pnca_p.his51gln","A","B","HIS","HA51","pnca_complex.pdb"
|
|
"H51R","L4","PZA","H","H51",51,"R",NA,"MDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",5.661,-0.862,-1.766,2.7037,-1.252,-1.48,74,85,-1.189,9,9,1,0.0044642857142857,"strand",1.36666666666667,6.97,0.001293661060802,24.3908629441624,24.3908627908724,24.3817411979725,51.2029377973759,-32,-2,0,0,-2,0,0,0,0,0,0,2,-2,0,0,0,0,-10,0,-2,-9,0,0,2,-2,-0.218338399189463,-0.456330749354005,0.0984746392383394,-0.213469735720375,-0.387434554973822,0.778947368421053,-0.979406919275124,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","H:Y",3.19420858638167,4.47975895465189e-07,0.632848408547862,5.04735185115046,8.04148719104289,105.368248724156,1.38722716584297,1.45797891284227e-09,8.83624875729546,6.89001106760784,131.337835841673,8.32938806400108e-13,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERR779915","ERR779915","lineage4.3.3","pe","","pnca_p.his51arg","A","B","HIS","HA51","pnca_complex.pdb"
|
|
"H51R","L4","PZA","H","H51",51,"R",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",5.661,-0.862,-1.766,2.7037,-1.252,-1.48,74,85,-1.189,9,9,1,0.0044642857142857,"strand",1.36666666666667,6.97,0.001293661060802,24.3908629441624,24.3908627908724,24.3817411979725,51.2029377973759,-32,-2,0,0,-2,0,0,0,0,0,0,2,-2,0,0,0,0,-10,0,-2,-9,0,0,2,-2,-0.218338399189463,-0.456330749354005,0.0984746392383394,-0.213469735720375,-0.387434554973822,0.778947368421053,-0.979406919275124,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","H:Y",3.19420858638167,4.47975895465189e-07,0.632848408547862,5.04735185115046,8.04148719104289,105.368248724156,1.38722716584297,1.45797891284227e-09,8.83624875729546,6.89001106760784,131.337835841673,8.32938806400108e-13,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERR751562","ERR751562","lineage4.3.3","pe","","pnca_p.his51arg","A","B","HIS","HA51","pnca_complex.pdb"
|
|
"H51R","L4","PZA","H","H51",51,"R",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",5.661,-0.862,-1.766,2.7037,-1.252,-1.48,74,85,-1.189,9,9,1,0.0044642857142857,"strand",1.36666666666667,6.97,0.001293661060802,24.3908629441624,24.3908627908724,24.3817411979725,51.2029377973759,-32,-2,0,0,-2,0,0,0,0,0,0,2,-2,0,0,0,0,-10,0,-2,-9,0,0,2,-2,-0.218338399189463,-0.456330749354005,0.0984746392383394,-0.213469735720375,-0.387434554973822,0.778947368421053,-0.979406919275124,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","H:Y",3.19420858638167,4.47975895465189e-07,0.632848408547862,5.04735185115046,8.04148719104289,105.368248724156,1.38722716584297,1.45797891284227e-09,8.83624875729546,6.89001106760784,131.337835841673,8.32938806400108e-13,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERR751553","ERR751553","lineage4.3.3","pe","","pnca_p.his51arg","A","B","HIS","HA51","pnca_complex.pdb"
|
|
"H51R","L4","PZA","H","H51",51,"R",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",5.661,-0.862,-1.766,2.7037,-1.252,-1.48,74,85,-1.189,9,9,1,0.0044642857142857,"strand",1.36666666666667,6.97,0.001293661060802,24.3908629441624,24.3908627908724,24.3817411979725,51.2029377973759,-32,-2,0,0,-2,0,0,0,0,0,0,2,-2,0,0,0,0,-10,0,-2,-9,0,0,2,-2,-0.218338399189463,-0.456330749354005,0.0984746392383394,-0.213469735720375,-0.387434554973822,0.778947368421053,-0.979406919275124,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","H:Y",3.19420858638167,4.47975895465189e-07,0.632848408547862,5.04735185115046,8.04148719104289,105.368248724156,1.38722716584297,1.45797891284227e-09,8.83624875729546,6.89001106760784,131.337835841673,8.32938806400108e-13,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERR779912","ERR779912","lineage4.3.3","pe","","pnca_p.his51arg","A","B","HIS","HA51","pnca_complex.pdb"
|
|
"H51R","L4","PZA","H","H51",51,"R",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",5.661,-0.862,-1.766,2.7037,-1.252,-1.48,74,85,-1.189,9,9,1,0.0044642857142857,"strand",1.36666666666667,6.97,0.001293661060802,24.3908629441624,24.3908627908724,24.3817411979725,51.2029377973759,-32,-2,0,0,-2,0,0,0,0,0,0,2,-2,0,0,0,0,-10,0,-2,-9,0,0,2,-2,-0.218338399189463,-0.456330749354005,0.0984746392383394,-0.213469735720375,-0.387434554973822,0.778947368421053,-0.979406919275124,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","H:Y",3.19420858638167,4.47975895465189e-07,0.632848408547862,5.04735185115046,8.04148719104289,105.368248724156,1.38722716584297,1.45797891284227e-09,8.83624875729546,6.89001106760784,131.337835841673,8.32938806400108e-13,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERR751448","ERR751448","lineage4.3.3","pe","","pnca_p.his51arg","A","B","HIS","HA51","pnca_complex.pdb"
|
|
"H51R","L4","PZA","H","H51",51,"R",NA,"MDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",5.661,-0.862,-1.766,2.7037,-1.252,-1.48,74,85,-1.189,9,9,1,0.0044642857142857,"strand",1.36666666666667,6.97,0.001293661060802,24.3908629441624,24.3908627908724,24.3817411979725,51.2029377973759,-32,-2,0,0,-2,0,0,0,0,0,0,2,-2,0,0,0,0,-10,0,-2,-9,0,0,2,-2,-0.218338399189463,-0.456330749354005,0.0984746392383394,-0.213469735720375,-0.387434554973822,0.778947368421053,-0.979406919275124,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","H:Y",3.19420858638167,4.47975895465189e-07,0.632848408547862,5.04735185115046,8.04148719104289,105.368248724156,1.38722716584297,1.45797891284227e-09,8.83624875729546,6.89001106760784,131.337835841673,8.32938806400108e-13,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERR751435","ERR751435","lineage4.3.3","pe","","pnca_p.his51arg","A","B","HIS","HA51","pnca_complex.pdb"
|
|
"H51R","L4","PZA","H","H51",51,"R",NA,"MDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",5.661,-0.862,-1.766,2.7037,-1.252,-1.48,74,85,-1.189,9,9,1,0.0044642857142857,"strand",1.36666666666667,6.97,0.001293661060802,24.3908629441624,24.3908627908724,24.3817411979725,51.2029377973759,-32,-2,0,0,-2,0,0,0,0,0,0,2,-2,0,0,0,0,-10,0,-2,-9,0,0,2,-2,-0.218338399189463,-0.456330749354005,0.0984746392383394,-0.213469735720375,-0.387434554973822,0.778947368421053,-0.979406919275124,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","H:Y",3.19420858638167,4.47975895465189e-07,0.632848408547862,5.04735185115046,8.04148719104289,105.368248724156,1.38722716584297,1.45797891284227e-09,8.83624875729546,6.89001106760784,131.337835841673,8.32938806400108e-13,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERR1034705","ERR1034705","lineage4.3.3","pe","Peru","pnca_p.his51arg","A","B","HIS","HA51","pnca_complex.pdb"
|
|
"H51R","L4","PZA","H","H51",51,"R",NA,"MDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",5.661,-0.862,-1.766,2.7037,-1.252,-1.48,74,85,-1.189,9,9,1,0.0044642857142857,"strand",1.36666666666667,6.97,0.001293661060802,24.3908629441624,24.3908627908724,24.3817411979725,51.2029377973759,-32,-2,0,0,-2,0,0,0,0,0,0,2,-2,0,0,0,0,-10,0,-2,-9,0,0,2,-2,-0.218338399189463,-0.456330749354005,0.0984746392383394,-0.213469735720375,-0.387434554973822,0.778947368421053,-0.979406919275124,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","H:Y",3.19420858638167,4.47975895465189e-07,0.632848408547862,5.04735185115046,8.04148719104289,105.368248724156,1.38722716584297,1.45797891284227e-09,8.83624875729546,6.89001106760784,131.337835841673,8.32938806400108e-13,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERR751587","ERR751587","lineage4.3.3","pe","","pnca_p.his51arg","A","B","HIS","HA51","pnca_complex.pdb"
|
|
"H51R","L4","PZA","H","H51",51,"R",NA,"MDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",5.661,-0.862,-1.766,2.7037,-1.252,-1.48,74,85,-1.189,9,9,1,0.0044642857142857,"strand",1.36666666666667,6.97,0.001293661060802,24.3908629441624,24.3908627908724,24.3817411979725,51.2029377973759,-32,-2,0,0,-2,0,0,0,0,0,0,2,-2,0,0,0,0,-10,0,-2,-9,0,0,2,-2,-0.218338399189463,-0.456330749354005,0.0984746392383394,-0.213469735720375,-0.387434554973822,0.778947368421053,-0.979406919275124,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","H:Y",3.19420858638167,4.47975895465189e-07,0.632848408547862,5.04735185115046,8.04148719104289,105.368248724156,1.38722716584297,1.45797891284227e-09,8.83624875729546,6.89001106760784,131.337835841673,8.32938806400108e-13,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERR775310","ERR775310","lineage4.3.3","pe","","pnca_p.his51arg","A","B","HIS","HA51","pnca_complex.pdb"
|
|
"H51R","L4","PZA","H","H51",51,"R",NA,"MDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",5.661,-0.862,-1.766,2.7037,-1.252,-1.48,74,85,-1.189,9,9,1,0.0044642857142857,"strand",1.36666666666667,6.97,0.001293661060802,24.3908629441624,24.3908627908724,24.3817411979725,51.2029377973759,-32,-2,0,0,-2,0,0,0,0,0,0,2,-2,0,0,0,0,-10,0,-2,-9,0,0,2,-2,-0.218338399189463,-0.456330749354005,0.0984746392383394,-0.213469735720375,-0.387434554973822,0.778947368421053,-0.979406919275124,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","H:Y",3.19420858638167,4.47975895465189e-07,0.632848408547862,5.04735185115046,8.04148719104289,105.368248724156,1.38722716584297,1.45797891284227e-09,8.83624875729546,6.89001106760784,131.337835841673,8.32938806400108e-13,"lineage4","dr_mutations_pyrazinamide","ARG",0,"SRR7517815","SRR7517815","lineage4.3.3","pe","Peru","pnca_p.his51arg","A","B","HIS","HA51","pnca_complex.pdb"
|
|
"H51R","L4","PZA","H","H51",51,"R",NA,"MDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",5.661,-0.862,-1.766,2.7037,-1.252,-1.48,74,85,-1.189,9,9,1,0.0044642857142857,"strand",1.36666666666667,6.97,0.001293661060802,24.3908629441624,24.3908627908724,24.3817411979725,51.2029377973759,-32,-2,0,0,-2,0,0,0,0,0,0,2,-2,0,0,0,0,-10,0,-2,-9,0,0,2,-2,-0.218338399189463,-0.456330749354005,0.0984746392383394,-0.213469735720375,-0.387434554973822,0.778947368421053,-0.979406919275124,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","H:Y",3.19420858638167,4.47975895465189e-07,0.632848408547862,5.04735185115046,8.04148719104289,105.368248724156,1.38722716584297,1.45797891284227e-09,8.83624875729546,6.89001106760784,131.337835841673,8.32938806400108e-13,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERR751567","ERR751567","lineage4.3.3","pe","","pnca_p.his51arg","A","B","HIS","HA51","pnca_complex.pdb"
|
|
"H51R","L4","PZA","H","H51",51,"R",NA,"MDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",5.661,-0.862,-1.766,2.7037,-1.252,-1.48,74,85,-1.189,9,9,1,0.0044642857142857,"strand",1.36666666666667,6.97,0.001293661060802,24.3908629441624,24.3908627908724,24.3817411979725,51.2029377973759,-32,-2,0,0,-2,0,0,0,0,0,0,2,-2,0,0,0,0,-10,0,-2,-9,0,0,2,-2,-0.218338399189463,-0.456330749354005,0.0984746392383394,-0.213469735720375,-0.387434554973822,0.778947368421053,-0.979406919275124,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","H:Y",3.19420858638167,4.47975895465189e-07,0.632848408547862,5.04735185115046,8.04148719104289,105.368248724156,1.38722716584297,1.45797891284227e-09,8.83624875729546,6.89001106760784,131.337835841673,8.32938806400108e-13,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERR751423","ERR751423","lineage4.3.3","pe","","pnca_p.his51arg","A","B","HIS","HA51","pnca_complex.pdb"
|
|
"H51R","L4","PZA","H","H51",51,"R",NA,"MDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",5.661,-0.862,-1.766,2.7037,-1.252,-1.48,74,85,-1.189,9,9,1,0.0044642857142857,"strand",1.36666666666667,6.97,0.001293661060802,24.3908629441624,24.3908627908724,24.3817411979725,51.2029377973759,-32,-2,0,0,-2,0,0,0,0,0,0,2,-2,0,0,0,0,-10,0,-2,-9,0,0,2,-2,-0.218338399189463,-0.456330749354005,0.0984746392383394,-0.213469735720375,-0.387434554973822,0.778947368421053,-0.979406919275124,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","H:Y",3.19420858638167,4.47975895465189e-07,0.632848408547862,5.04735185115046,8.04148719104289,105.368248724156,1.38722716584297,1.45797891284227e-09,8.83624875729546,6.89001106760784,131.337835841673,8.32938806400108e-13,"lineage4","dr_mutations_pyrazinamide","ARG",0,"SRR7517816","SRR7517816","lineage4.3.3","pe","Peru","pnca_p.his51arg","A","B","HIS","HA51","pnca_complex.pdb"
|
|
"H51R","L4","PZA","H","H51",51,"R",NA,"MDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",5.661,-0.862,-1.766,2.7037,-1.252,-1.48,74,85,-1.189,9,9,1,0.0044642857142857,"strand",1.36666666666667,6.97,0.001293661060802,24.3908629441624,24.3908627908724,24.3817411979725,51.2029377973759,-32,-2,0,0,-2,0,0,0,0,0,0,2,-2,0,0,0,0,-10,0,-2,-9,0,0,2,-2,-0.218338399189463,-0.456330749354005,0.0984746392383394,-0.213469735720375,-0.387434554973822,0.778947368421053,-0.979406919275124,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","H:Y",3.19420858638167,4.47975895465189e-07,0.632848408547862,5.04735185115046,8.04148719104289,105.368248724156,1.38722716584297,1.45797891284227e-09,8.83624875729546,6.89001106760784,131.337835841673,8.32938806400108e-13,"lineage4","dr_mutations_pyrazinamide","ARG",0,"SRR3732594","SRR3732594","lineage4.3.3","pe","Peru","pnca_p.his51arg","A","B","HIS","HA51","pnca_complex.pdb"
|
|
"H51R","L4","PZA","H","H51",51,"R",NA,"MDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",5.661,-0.862,-1.766,2.7037,-1.252,-1.48,74,85,-1.189,9,9,1,0.0044642857142857,"strand",1.36666666666667,6.97,0.001293661060802,24.3908629441624,24.3908627908724,24.3817411979725,51.2029377973759,-32,-2,0,0,-2,0,0,0,0,0,0,2,-2,0,0,0,0,-10,0,-2,-9,0,0,2,-2,-0.218338399189463,-0.456330749354005,0.0984746392383394,-0.213469735720375,-0.387434554973822,0.778947368421053,-0.979406919275124,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","H:Y",3.19420858638167,4.47975895465189e-07,0.632848408547862,5.04735185115046,8.04148719104289,105.368248724156,1.38722716584297,1.45797891284227e-09,8.83624875729546,6.89001106760784,131.337835841673,8.32938806400108e-13,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERR751458","ERR751458","lineage4.3.3","pe","","pnca_p.his51arg","A","B","HIS","HA51","pnca_complex.pdb"
|
|
"H51R","L4","PZA","H","H51",51,"R",NA,"MDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",5.661,-0.862,-1.766,2.7037,-1.252,-1.48,74,85,-1.189,9,9,1,0.0044642857142857,"strand",1.36666666666667,6.97,0.001293661060802,24.3908629441624,24.3908627908724,24.3817411979725,51.2029377973759,-32,-2,0,0,-2,0,0,0,0,0,0,2,-2,0,0,0,0,-10,0,-2,-9,0,0,2,-2,-0.218338399189463,-0.456330749354005,0.0984746392383394,-0.213469735720375,-0.387434554973822,0.778947368421053,-0.979406919275124,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","H:Y",3.19420858638167,4.47975895465189e-07,0.632848408547862,5.04735185115046,8.04148719104289,105.368248724156,1.38722716584297,1.45797891284227e-09,8.83624875729546,6.89001106760784,131.337835841673,8.32938806400108e-13,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERR751445","ERR751445","lineage4.3.3","pe","","pnca_p.his51arg","A","B","HIS","HA51","pnca_complex.pdb"
|
|
"H51R","L4","PZA","H","H51",51,"R",NA,"MDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",5.661,-0.862,-1.766,2.7037,-1.252,-1.48,74,85,-1.189,9,9,1,0.0044642857142857,"strand",1.36666666666667,6.97,0.001293661060802,24.3908629441624,24.3908627908724,24.3817411979725,51.2029377973759,-32,-2,0,0,-2,0,0,0,0,0,0,2,-2,0,0,0,0,-10,0,-2,-9,0,0,2,-2,-0.218338399189463,-0.456330749354005,0.0984746392383394,-0.213469735720375,-0.387434554973822,0.778947368421053,-0.979406919275124,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","H:Y",3.19420858638167,4.47975895465189e-07,0.632848408547862,5.04735185115046,8.04148719104289,105.368248724156,1.38722716584297,1.45797891284227e-09,8.83624875729546,6.89001106760784,131.337835841673,8.32938806400108e-13,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERR2510172","ERR2510172","lineage4.3.3","pe","Peru","pnca_p.his51arg","A","B","HIS","HA51","pnca_complex.pdb"
|
|
"H51R","L4","PZA","H","H51",51,"R",1,"MDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",5.661,-0.862,-1.766,2.7037,-1.252,-1.48,74,85,-1.189,9,9,1,0.0044642857142857,"strand",1.36666666666667,6.97,0.001293661060802,24.3908629441624,24.3908627908724,24.3817411979725,51.2029377973759,-32,-2,0,0,-2,0,0,0,0,0,0,2,-2,0,0,0,0,-10,0,-2,-9,0,0,2,-2,-0.218338399189463,-0.456330749354005,0.0984746392383394,-0.213469735720375,-0.387434554973822,0.778947368421053,-0.979406919275124,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","H:Y",3.19420858638167,4.47975895465189e-07,0.632848408547862,5.04735185115046,8.04148719104289,105.368248724156,1.38722716584297,1.45797891284227e-09,8.83624875729546,6.89001106760784,131.337835841673,8.32938806400108e-13,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERR2516610","ERR2516610","lineage4.3.3","pe","Peru","pnca_p.his51arg","A","B","HIS","HA51","pnca_complex.pdb"
|
|
"H51R","L4","PZA","H","H51",51,"R",NA,"MDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",5.661,-0.862,-1.766,2.7037,-1.252,-1.48,74,85,-1.189,9,9,1,0.0044642857142857,"strand",1.36666666666667,6.97,0.001293661060802,24.3908629441624,24.3908627908724,24.3817411979725,51.2029377973759,-32,-2,0,0,-2,0,0,0,0,0,0,2,-2,0,0,0,0,-10,0,-2,-9,0,0,2,-2,-0.218338399189463,-0.456330749354005,0.0984746392383394,-0.213469735720375,-0.387434554973822,0.778947368421053,-0.979406919275124,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","H:Y",3.19420858638167,4.47975895465189e-07,0.632848408547862,5.04735185115046,8.04148719104289,105.368248724156,1.38722716584297,1.45797891284227e-09,8.83624875729546,6.89001106760784,131.337835841673,8.32938806400108e-13,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERR775300","ERR775300","lineage4.3.3","pe","","pnca_p.his51arg","A","B","HIS","HA51","pnca_complex.pdb"
|
|
"H51R","L4","PZA","H","H51",51,"R",NA,"MDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",5.661,-0.862,-1.766,2.7037,-1.252,-1.48,74,85,-1.189,9,9,1,0.0044642857142857,"strand",1.36666666666667,6.97,0.001293661060802,24.3908629441624,24.3908627908724,24.3817411979725,51.2029377973759,-32,-2,0,0,-2,0,0,0,0,0,0,2,-2,0,0,0,0,-10,0,-2,-9,0,0,2,-2,-0.218338399189463,-0.456330749354005,0.0984746392383394,-0.213469735720375,-0.387434554973822,0.778947368421053,-0.979406919275124,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","H:Y",3.19420858638167,4.47975895465189e-07,0.632848408547862,5.04735185115046,8.04148719104289,105.368248724156,1.38722716584297,1.45797891284227e-09,8.83624875729546,6.89001106760784,131.337835841673,8.32938806400108e-13,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERR2510197","ERR2510197","lineage4.3.3","pe","Peru","pnca_p.his51arg","A","B","HIS","HA51","pnca_complex.pdb"
|
|
"H51R","L4","PZA","H","H51",51,"R",NA,"MDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",5.661,-0.862,-1.766,2.7037,-1.252,-1.48,74,85,-1.189,9,9,1,0.0044642857142857,"strand",1.36666666666667,6.97,0.001293661060802,24.3908629441624,24.3908627908724,24.3817411979725,51.2029377973759,-32,-2,0,0,-2,0,0,0,0,0,0,2,-2,0,0,0,0,-10,0,-2,-9,0,0,2,-2,-0.218338399189463,-0.456330749354005,0.0984746392383394,-0.213469735720375,-0.387434554973822,0.778947368421053,-0.979406919275124,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","H:Y",3.19420858638167,4.47975895465189e-07,0.632848408547862,5.04735185115046,8.04148719104289,105.368248724156,1.38722716584297,1.45797891284227e-09,8.83624875729546,6.89001106760784,131.337835841673,8.32938806400108e-13,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERR775315","ERR775315","lineage4.3.3","pe","","pnca_p.his51arg","A","B","HIS","HA51","pnca_complex.pdb"
|
|
"H51R","L4","PZA","H","H51",51,"R",NA,"MDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",5.661,-0.862,-1.766,2.7037,-1.252,-1.48,74,85,-1.189,9,9,1,0.0044642857142857,"strand",1.36666666666667,6.97,0.001293661060802,24.3908629441624,24.3908627908724,24.3817411979725,51.2029377973759,-32,-2,0,0,-2,0,0,0,0,0,0,2,-2,0,0,0,0,-10,0,-2,-9,0,0,2,-2,-0.218338399189463,-0.456330749354005,0.0984746392383394,-0.213469735720375,-0.387434554973822,0.778947368421053,-0.979406919275124,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","H:Y",3.19420858638167,4.47975895465189e-07,0.632848408547862,5.04735185115046,8.04148719104289,105.368248724156,1.38722716584297,1.45797891284227e-09,8.83624875729546,6.89001106760784,131.337835841673,8.32938806400108e-13,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERR751628","ERR751628","lineage4.3.3","pe","","pnca_p.his51arg","A","B","HIS","HA51","pnca_complex.pdb"
|
|
"H51R","L4","PZA","H","H51",51,"R",1,"MDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",5.661,-0.862,-1.766,2.7037,-1.252,-1.48,74,85,-1.189,9,9,1,0.0044642857142857,"strand",1.36666666666667,6.97,0.001293661060802,24.3908629441624,24.3908627908724,24.3817411979725,51.2029377973759,-32,-2,0,0,-2,0,0,0,0,0,0,2,-2,0,0,0,0,-10,0,-2,-9,0,0,2,-2,-0.218338399189463,-0.456330749354005,0.0984746392383394,-0.213469735720375,-0.387434554973822,0.778947368421053,-0.979406919275124,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","H:Y",3.19420858638167,4.47975895465189e-07,0.632848408547862,5.04735185115046,8.04148719104289,105.368248724156,1.38722716584297,1.45797891284227e-09,8.83624875729546,6.89001106760784,131.337835841673,8.32938806400108e-13,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERR2516465","ERR2516465","lineage4.3.3","pe","Peru","pnca_p.his51arg","A","B","HIS","HA51","pnca_complex.pdb"
|
|
"H51R","L4","PZA","H","H51",51,"R",1,"MDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",5.661,-0.862,-1.766,2.7037,-1.252,-1.48,74,85,-1.189,9,9,1,0.0044642857142857,"strand",1.36666666666667,6.97,0.001293661060802,24.3908629441624,24.3908627908724,24.3817411979725,51.2029377973759,-32,-2,0,0,-2,0,0,0,0,0,0,2,-2,0,0,0,0,-10,0,-2,-9,0,0,2,-2,-0.218338399189463,-0.456330749354005,0.0984746392383394,-0.213469735720375,-0.387434554973822,0.778947368421053,-0.979406919275124,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","H:Y",3.19420858638167,4.47975895465189e-07,0.632848408547862,5.04735185115046,8.04148719104289,105.368248724156,1.38722716584297,1.45797891284227e-09,8.83624875729546,6.89001106760784,131.337835841673,8.32938806400108e-13,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERR2516462","ERR2516462","lineage4.3.3","pe","Peru","pnca_p.his51arg","A","B","HIS","HA51","pnca_complex.pdb"
|
|
"H51R","L2","PZA","H","H51",51,"R",1,"MDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",5.661,-0.862,-1.766,2.7037,-1.252,-1.48,74,85,-1.189,9,9,1,0.0044642857142857,"strand",1.36666666666667,6.97,0.001293661060802,24.3908629441624,24.3908627908724,24.3817411979725,51.2029377973759,-32,-2,0,0,-2,0,0,0,0,0,0,2,-2,0,0,0,0,-10,0,-2,-9,0,0,2,-2,-0.218338399189463,-0.456330749354005,0.0984746392383394,-0.213469735720375,-0.387434554973822,0.778947368421053,-0.979406919275124,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","H:Y",3.19420858638167,4.47975895465189e-07,0.632848408547862,5.04735185115046,8.04148719104289,105.368248724156,1.38722716584297,1.45797891284227e-09,8.83624875729546,6.89001106760784,131.337835841673,8.32938806400108e-13,"lineage2","dr_mutations_pyrazinamide","ARG",0,"ERR2516217","ERR2516217","lineage2.2.1","be","Belgium","pnca_p.his51arg","A","B","HIS","HA51","pnca_complex.pdb"
|
|
"H51R","L4","PZA","H","H51",51,"R",1,"Pre-XDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",5.661,-0.862,-1.766,2.7037,-1.252,-1.48,74,85,-1.189,9,9,1,0.0044642857142857,"strand",1.36666666666667,6.97,0.001293661060802,24.3908629441624,24.3908627908724,24.3817411979725,51.2029377973759,-32,-2,0,0,-2,0,0,0,0,0,0,2,-2,0,0,0,0,-10,0,-2,-9,0,0,2,-2,-0.218338399189463,-0.456330749354005,0.0984746392383394,-0.213469735720375,-0.387434554973822,0.778947368421053,-0.979406919275124,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","H:Y",3.19420858638167,4.47975895465189e-07,0.632848408547862,5.04735185115046,8.04148719104289,105.368248724156,1.38722716584297,1.45797891284227e-09,8.83624875729546,6.89001106760784,131.337835841673,8.32938806400108e-13,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERR2516408","ERR2516408","lineage4.3.3","pe","Peru","pnca_p.his51arg","A","B","HIS","HA51","pnca_complex.pdb"
|
|
"H51R","L4","PZA","H","H51",51,"R",NA,"MDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",5.661,-0.862,-1.766,2.7037,-1.252,-1.48,74,85,-1.189,9,9,1,0.0044642857142857,"strand",1.36666666666667,6.97,0.001293661060802,24.3908629441624,24.3908627908724,24.3817411979725,51.2029377973759,-32,-2,0,0,-2,0,0,0,0,0,0,2,-2,0,0,0,0,-10,0,-2,-9,0,0,2,-2,-0.218338399189463,-0.456330749354005,0.0984746392383394,-0.213469735720375,-0.387434554973822,0.778947368421053,-0.979406919275124,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","H:Y",3.19420858638167,4.47975895465189e-07,0.632848408547862,5.04735185115046,8.04148719104289,105.368248724156,1.38722716584297,1.45797891284227e-09,8.83624875729546,6.89001106760784,131.337835841673,8.32938806400108e-13,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERR751551","ERR751551","lineage4.3.3","pe","","pnca_p.his51arg","A","B","HIS","HA51","pnca_complex.pdb"
|
|
"H51R","L3","PZA","H","H51",51,"R",NA,"MDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",5.661,-0.862,-1.766,2.7037,-1.252,-1.48,74,85,-1.189,9,9,1,0.0044642857142857,"strand",1.36666666666667,6.97,0.001293661060802,24.3908629441624,24.3908627908724,24.3817411979725,51.2029377973759,-32,-2,0,0,-2,0,0,0,0,0,0,2,-2,0,0,0,0,-10,0,-2,-9,0,0,2,-2,-0.218338399189463,-0.456330749354005,0.0984746392383394,-0.213469735720375,-0.387434554973822,0.778947368421053,-0.979406919275124,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","H:Y",3.19420858638167,4.47975895465189e-07,0.632848408547862,5.04735185115046,8.04148719104289,105.368248724156,1.38722716584297,1.45797891284227e-09,8.83624875729546,6.89001106760784,131.337835841673,8.32938806400108e-13,"lineage3","dr_mutations_pyrazinamide","ARG",0,"ERR2514867","ERR2514867","lineage3","gb","UK","pnca_p.his51arg","A","B","HIS","HA51","pnca_complex.pdb"
|
|
"H51R","L4","PZA","H","H51",51,"R",NA,"MDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",5.661,-0.862,-1.766,2.7037,-1.252,-1.48,74,85,-1.189,9,9,1,0.0044642857142857,"strand",1.36666666666667,6.97,0.001293661060802,24.3908629441624,24.3908627908724,24.3817411979725,51.2029377973759,-32,-2,0,0,-2,0,0,0,0,0,0,2,-2,0,0,0,0,-10,0,-2,-9,0,0,2,-2,-0.218338399189463,-0.456330749354005,0.0984746392383394,-0.213469735720375,-0.387434554973822,0.778947368421053,-0.979406919275124,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","H:Y",3.19420858638167,4.47975895465189e-07,0.632848408547862,5.04735185115046,8.04148719104289,105.368248724156,1.38722716584297,1.45797891284227e-09,8.83624875729546,6.89001106760784,131.337835841673,8.32938806400108e-13,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERR751362","ERR751362","lineage4.3.3","pe","","pnca_p.his51arg","A","B","HIS","HA51","pnca_complex.pdb"
|
|
"H51R","L4","PZA","H","H51",51,"R",NA,"MDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",5.661,-0.862,-1.766,2.7037,-1.252,-1.48,74,85,-1.189,9,9,1,0.0044642857142857,"strand",1.36666666666667,6.97,0.001293661060802,24.3908629441624,24.3908627908724,24.3817411979725,51.2029377973759,-32,-2,0,0,-2,0,0,0,0,0,0,2,-2,0,0,0,0,-10,0,-2,-9,0,0,2,-2,-0.218338399189463,-0.456330749354005,0.0984746392383394,-0.213469735720375,-0.387434554973822,0.778947368421053,-0.979406919275124,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","H:Y",3.19420858638167,4.47975895465189e-07,0.632848408547862,5.04735185115046,8.04148719104289,105.368248724156,1.38722716584297,1.45797891284227e-09,8.83624875729546,6.89001106760784,131.337835841673,8.32938806400108e-13,"lineage4","dr_mutations_pyrazinamide","ARG",0,"SRR7517836","SRR7517836","lineage4.3.3","pe","Peru","pnca_p.his51arg","A","B","HIS","HA51","pnca_complex.pdb"
|
|
"H51R","L4","PZA","H","H51",51,"R",NA,"MDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",5.661,-0.862,-1.766,2.7037,-1.252,-1.48,74,85,-1.189,9,9,1,0.0044642857142857,"strand",1.36666666666667,6.97,0.001293661060802,24.3908629441624,24.3908627908724,24.3817411979725,51.2029377973759,-32,-2,0,0,-2,0,0,0,0,0,0,2,-2,0,0,0,0,-10,0,-2,-9,0,0,2,-2,-0.218338399189463,-0.456330749354005,0.0984746392383394,-0.213469735720375,-0.387434554973822,0.778947368421053,-0.979406919275124,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","H:Y",3.19420858638167,4.47975895465189e-07,0.632848408547862,5.04735185115046,8.04148719104289,105.368248724156,1.38722716584297,1.45797891284227e-09,8.83624875729546,6.89001106760784,131.337835841673,8.32938806400108e-13,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERR2510141","ERR2510141","lineage4.3.3","pe","Peru","pnca_p.his51arg","A","B","HIS","HA51","pnca_complex.pdb"
|
|
"H51R","L4","PZA","H","H51",51,"R",NA,"MDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",5.661,-0.862,-1.766,2.7037,-1.252,-1.48,74,85,-1.189,9,9,1,0.0044642857142857,"strand",1.36666666666667,6.97,0.001293661060802,24.3908629441624,24.3908627908724,24.3817411979725,51.2029377973759,-32,-2,0,0,-2,0,0,0,0,0,0,2,-2,0,0,0,0,-10,0,-2,-9,0,0,2,-2,-0.218338399189463,-0.456330749354005,0.0984746392383394,-0.213469735720375,-0.387434554973822,0.778947368421053,-0.979406919275124,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","H:Y",3.19420858638167,4.47975895465189e-07,0.632848408547862,5.04735185115046,8.04148719104289,105.368248724156,1.38722716584297,1.45797891284227e-09,8.83624875729546,6.89001106760784,131.337835841673,8.32938806400108e-13,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERR751600","ERR751600","lineage4.3.3","pe","","pnca_p.his51arg","A","B","HIS","HA51","pnca_complex.pdb"
|
|
"H51R","L2","PZA","H","H51",51,"R",0,"Pre-XDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",5.661,-0.862,-1.766,2.7037,-1.252,-1.48,74,85,-1.189,9,9,1,0.0044642857142857,"strand",1.36666666666667,6.97,0.001293661060802,24.3908629441624,24.3908627908724,24.3817411979725,51.2029377973759,-32,-2,0,0,-2,0,0,0,0,0,0,2,-2,0,0,0,0,-10,0,-2,-9,0,0,2,-2,-0.218338399189463,-0.456330749354005,0.0984746392383394,-0.213469735720375,-0.387434554973822,0.778947368421053,-0.979406919275124,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","H:Y",3.19420858638167,4.47975895465189e-07,0.632848408547862,5.04735185115046,8.04148719104289,105.368248724156,1.38722716584297,1.45797891284227e-09,8.83624875729546,6.89001106760784,131.337835841673,8.32938806400108e-13,"lineage2","dr_mutations_pyrazinamide","ARG",0,"ERR108500,0069B-sc-2011-10-12T14:59:28Z-1289165","ERR108500","lineage2.2.1","ru","Russia,Samara","pnca_p.his51arg","A","B","HIS","HA51","pnca_complex.pdb"
|
|
"H51R","L4","PZA","H","H51",51,"R",NA,"MDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",5.661,-0.862,-1.766,2.7037,-1.252,-1.48,74,85,-1.189,9,9,1,0.0044642857142857,"strand",1.36666666666667,6.97,0.001293661060802,24.3908629441624,24.3908627908724,24.3817411979725,51.2029377973759,-32,-2,0,0,-2,0,0,0,0,0,0,2,-2,0,0,0,0,-10,0,-2,-9,0,0,2,-2,-0.218338399189463,-0.456330749354005,0.0984746392383394,-0.213469735720375,-0.387434554973822,0.778947368421053,-0.979406919275124,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","H:Y",3.19420858638167,4.47975895465189e-07,0.632848408547862,5.04735185115046,8.04148719104289,105.368248724156,1.38722716584297,1.45797891284227e-09,8.83624875729546,6.89001106760784,131.337835841673,8.32938806400108e-13,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERR751377","ERR751377","lineage4.3.3","pe","","pnca_p.his51arg","A","B","HIS","HA51","pnca_complex.pdb"
|
|
"H51R","L4","PZA","H","H51",51,"R",NA,"MDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",5.661,-0.862,-1.766,2.7037,-1.252,-1.48,74,85,-1.189,9,9,1,0.0044642857142857,"strand",1.36666666666667,6.97,0.001293661060802,24.3908629441624,24.3908627908724,24.3817411979725,51.2029377973759,-32,-2,0,0,-2,0,0,0,0,0,0,2,-2,0,0,0,0,-10,0,-2,-9,0,0,2,-2,-0.218338399189463,-0.456330749354005,0.0984746392383394,-0.213469735720375,-0.387434554973822,0.778947368421053,-0.979406919275124,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","H:Y",3.19420858638167,4.47975895465189e-07,0.632848408547862,5.04735185115046,8.04148719104289,105.368248724156,1.38722716584297,1.45797891284227e-09,8.83624875729546,6.89001106760784,131.337835841673,8.32938806400108e-13,"lineage4","dr_mutations_pyrazinamide","ARG",0,"SRR7517770","SRR7517770","lineage4.3.3","pe","Peru","pnca_p.his51arg","A","B","HIS","HA51","pnca_complex.pdb"
|
|
"H51R","L4","PZA","H","H51",51,"R",1,"MDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",5.661,-0.862,-1.766,2.7037,-1.252,-1.48,74,85,-1.189,9,9,1,0.0044642857142857,"strand",1.36666666666667,6.97,0.001293661060802,24.3908629441624,24.3908627908724,24.3817411979725,51.2029377973759,-32,-2,0,0,-2,0,0,0,0,0,0,2,-2,0,0,0,0,-10,0,-2,-9,0,0,2,-2,-0.218338399189463,-0.456330749354005,0.0984746392383394,-0.213469735720375,-0.387434554973822,0.778947368421053,-0.979406919275124,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","H:Y",3.19420858638167,4.47975895465189e-07,0.632848408547862,5.04735185115046,8.04148719104289,105.368248724156,1.38722716584297,1.45797891284227e-09,8.83624875729546,6.89001106760784,131.337835841673,8.32938806400108e-13,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERR2516558","ERR2516558","lineage4.3.3","pe","Peru","pnca_p.his51arg","A","B","HIS","HA51","pnca_complex.pdb"
|
|
"H51R","L4","PZA","H","H51",51,"R",NA,"MDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",5.661,-0.862,-1.766,2.7037,-1.252,-1.48,74,85,-1.189,9,9,1,0.0044642857142857,"strand",1.36666666666667,6.97,0.001293661060802,24.3908629441624,24.3908627908724,24.3817411979725,51.2029377973759,-32,-2,0,0,-2,0,0,0,0,0,0,2,-2,0,0,0,0,-10,0,-2,-9,0,0,2,-2,-0.218338399189463,-0.456330749354005,0.0984746392383394,-0.213469735720375,-0.387434554973822,0.778947368421053,-0.979406919275124,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","H:Y",3.19420858638167,4.47975895465189e-07,0.632848408547862,5.04735185115046,8.04148719104289,105.368248724156,1.38722716584297,1.45797891284227e-09,8.83624875729546,6.89001106760784,131.337835841673,8.32938806400108e-13,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERR775337","ERR775337","lineage4.3.3","pe","","pnca_p.his51arg","A","B","HIS","HA51","pnca_complex.pdb"
|
|
"H51R","L4","PZA","H","H51",51,"R",NA,"MDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",5.661,-0.862,-1.766,2.7037,-1.252,-1.48,74,85,-1.189,9,9,1,0.0044642857142857,"strand",1.36666666666667,6.97,0.001293661060802,24.3908629441624,24.3908627908724,24.3817411979725,51.2029377973759,-32,-2,0,0,-2,0,0,0,0,0,0,2,-2,0,0,0,0,-10,0,-2,-9,0,0,2,-2,-0.218338399189463,-0.456330749354005,0.0984746392383394,-0.213469735720375,-0.387434554973822,0.778947368421053,-0.979406919275124,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","H:Y",3.19420858638167,4.47975895465189e-07,0.632848408547862,5.04735185115046,8.04148719104289,105.368248724156,1.38722716584297,1.45797891284227e-09,8.83624875729546,6.89001106760784,131.337835841673,8.32938806400108e-13,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERR775332","ERR775332","lineage4.3.3","pe","","pnca_p.his51arg","A","B","HIS","HA51","pnca_complex.pdb"
|
|
"H51R","L4","PZA","H","H51",51,"R",NA,"MDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",5.661,-0.862,-1.766,2.7037,-1.252,-1.48,74,85,-1.189,9,9,1,0.0044642857142857,"strand",1.36666666666667,6.97,0.001293661060802,24.3908629441624,24.3908627908724,24.3817411979725,51.2029377973759,-32,-2,0,0,-2,0,0,0,0,0,0,2,-2,0,0,0,0,-10,0,-2,-9,0,0,2,-2,-0.218338399189463,-0.456330749354005,0.0984746392383394,-0.213469735720375,-0.387434554973822,0.778947368421053,-0.979406919275124,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","H:Y",3.19420858638167,4.47975895465189e-07,0.632848408547862,5.04735185115046,8.04148719104289,105.368248724156,1.38722716584297,1.45797891284227e-09,8.83624875729546,6.89001106760784,131.337835841673,8.32938806400108e-13,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERR751566","ERR751566","lineage4.3.3","pe","","pnca_p.his51arg","A","B","HIS","HA51","pnca_complex.pdb"
|
|
"H51R","L4","PZA","H","H51",51,"R",1,"MDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",5.661,-0.862,-1.766,2.7037,-1.252,-1.48,74,85,-1.189,9,9,1,0.0044642857142857,"strand",1.36666666666667,6.97,0.001293661060802,24.3908629441624,24.3908627908724,24.3817411979725,51.2029377973759,-32,-2,0,0,-2,0,0,0,0,0,0,2,-2,0,0,0,0,-10,0,-2,-9,0,0,2,-2,-0.218338399189463,-0.456330749354005,0.0984746392383394,-0.213469735720375,-0.387434554973822,0.778947368421053,-0.979406919275124,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","H:Y",3.19420858638167,4.47975895465189e-07,0.632848408547862,5.04735185115046,8.04148719104289,105.368248724156,1.38722716584297,1.45797891284227e-09,8.83624875729546,6.89001106760784,131.337835841673,8.32938806400108e-13,"lineage4","dr_mutations_pyrazinamide","ARG",0,"MDR_11125","SRR6824686","lineage4.5","cn","China: Luqiao District, Taizhou City, Zhejiang Province","pnca_p.his51arg","A","B","HIS","HA51","pnca_complex.pdb"
|
|
"H51R","L4","PZA","H","H51",51,"R",NA,"MDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",5.661,-0.862,-1.766,2.7037,-1.252,-1.48,74,85,-1.189,9,9,1,0.0044642857142857,"strand",1.36666666666667,6.97,0.001293661060802,24.3908629441624,24.3908627908724,24.3817411979725,51.2029377973759,-32,-2,0,0,-2,0,0,0,0,0,0,2,-2,0,0,0,0,-10,0,-2,-9,0,0,2,-2,-0.218338399189463,-0.456330749354005,0.0984746392383394,-0.213469735720375,-0.387434554973822,0.778947368421053,-0.979406919275124,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","H:Y",3.19420858638167,4.47975895465189e-07,0.632848408547862,5.04735185115046,8.04148719104289,105.368248724156,1.38722716584297,1.45797891284227e-09,8.83624875729546,6.89001106760784,131.337835841673,8.32938806400108e-13,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERR2510212","ERR2510212","lineage4.3.3","pe","Peru","pnca_p.his51arg","A","B","HIS","HA51","pnca_complex.pdb"
|
|
"H51R","L4","PZA","H","H51",51,"R",1,"Pre-MDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",5.661,-0.862,-1.766,2.7037,-1.252,-1.48,74,85,-1.189,9,9,1,0.0044642857142857,"strand",1.36666666666667,6.97,0.001293661060802,24.3908629441624,24.3908627908724,24.3817411979725,51.2029377973759,-32,-2,0,0,-2,0,0,0,0,0,0,2,-2,0,0,0,0,-10,0,-2,-9,0,0,2,-2,-0.218338399189463,-0.456330749354005,0.0984746392383394,-0.213469735720375,-0.387434554973822,0.778947368421053,-0.979406919275124,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","H:Y",3.19420858638167,4.47975895465189e-07,0.632848408547862,5.04735185115046,8.04148719104289,105.368248724156,1.38722716584297,1.45797891284227e-09,8.83624875729546,6.89001106760784,131.337835841673,8.32938806400108e-13,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERR1034719","ERR1034719","lineage4.3.3","pe","Peru","pnca_p.his51arg","A","B","HIS","HA51","pnca_complex.pdb"
|
|
"H51R","L4","PZA","H","H51",51,"R",NA,"MDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",5.661,-0.862,-1.766,2.7037,-1.252,-1.48,74,85,-1.189,9,9,1,0.0044642857142857,"strand",1.36666666666667,6.97,0.001293661060802,24.3908629441624,24.3908627908724,24.3817411979725,51.2029377973759,-32,-2,0,0,-2,0,0,0,0,0,0,2,-2,0,0,0,0,-10,0,-2,-9,0,0,2,-2,-0.218338399189463,-0.456330749354005,0.0984746392383394,-0.213469735720375,-0.387434554973822,0.778947368421053,-0.979406919275124,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","H:Y",3.19420858638167,4.47975895465189e-07,0.632848408547862,5.04735185115046,8.04148719104289,105.368248724156,1.38722716584297,1.45797891284227e-09,8.83624875729546,6.89001106760784,131.337835841673,8.32938806400108e-13,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERR845941","ERR845941","lineage4.3.3","pe","","pnca_p.his51arg","A","B","HIS","HA51","pnca_complex.pdb"
|
|
"H51R","L2","PZA","H","H51",51,"R",1,"XDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",5.661,-0.862,-1.766,2.7037,-1.252,-1.48,74,85,-1.189,9,9,1,0.0044642857142857,"strand",1.36666666666667,6.97,0.001293661060802,24.3908629441624,24.3908627908724,24.3817411979725,51.2029377973759,-32,-2,0,0,-2,0,0,0,0,0,0,2,-2,0,0,0,0,-10,0,-2,-9,0,0,2,-2,-0.218338399189463,-0.456330749354005,0.0984746392383394,-0.213469735720375,-0.387434554973822,0.778947368421053,-0.979406919275124,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","H:Y",3.19420858638167,4.47975895465189e-07,0.632848408547862,5.04735185115046,8.04148719104289,105.368248724156,1.38722716584297,1.45797891284227e-09,8.83624875729546,6.89001106760784,131.337835841673,8.32938806400108e-13,"lineage2","dr_mutations_pyrazinamide","ARG",0,"SAMN10961324","SRR8651654","lineage2.2.1","cn","China:Wenzhou","pnca_p.his51arg","A","B","HIS","HA51","pnca_complex.pdb"
|
|
"H51R","L4","PZA","H","H51",51,"R",1,"MDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",5.661,-0.862,-1.766,2.7037,-1.252,-1.48,74,85,-1.189,9,9,1,0.0044642857142857,"strand",1.36666666666667,6.97,0.001293661060802,24.3908629441624,24.3908627908724,24.3817411979725,51.2029377973759,-32,-2,0,0,-2,0,0,0,0,0,0,2,-2,0,0,0,0,-10,0,-2,-9,0,0,2,-2,-0.218338399189463,-0.456330749354005,0.0984746392383394,-0.213469735720375,-0.387434554973822,0.778947368421053,-0.979406919275124,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","H:Y",3.19420858638167,4.47975895465189e-07,0.632848408547862,5.04735185115046,8.04148719104289,105.368248724156,1.38722716584297,1.45797891284227e-09,8.83624875729546,6.89001106760784,131.337835841673,8.32938806400108e-13,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERR2516560","ERR2516560","lineage4.3.3","pe","Peru","pnca_p.his51arg","A","B","HIS","HA51","pnca_complex.pdb"
|
|
"H51R","L4","PZA","H","H51",51,"R",NA,"MDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",5.661,-0.862,-1.766,2.7037,-1.252,-1.48,74,85,-1.189,9,9,1,0.0044642857142857,"strand",1.36666666666667,6.97,0.001293661060802,24.3908629441624,24.3908627908724,24.3817411979725,51.2029377973759,-32,-2,0,0,-2,0,0,0,0,0,0,2,-2,0,0,0,0,-10,0,-2,-9,0,0,2,-2,-0.218338399189463,-0.456330749354005,0.0984746392383394,-0.213469735720375,-0.387434554973822,0.778947368421053,-0.979406919275124,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","H:Y",3.19420858638167,4.47975895465189e-07,0.632848408547862,5.04735185115046,8.04148719104289,105.368248724156,1.38722716584297,1.45797891284227e-09,8.83624875729546,6.89001106760784,131.337835841673,8.32938806400108e-13,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERR751612","ERR751612","lineage4.3.3","pe","","pnca_p.his51arg","A","B","HIS","HA51","pnca_complex.pdb"
|
|
"H51R","L4","PZA","H","H51",51,"R",1,"Pre-XDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",5.661,-0.862,-1.766,2.7037,-1.252,-1.48,74,85,-1.189,9,9,1,0.0044642857142857,"strand",1.36666666666667,6.97,0.001293661060802,24.3908629441624,24.3908627908724,24.3817411979725,51.2029377973759,-32,-2,0,0,-2,0,0,0,0,0,0,2,-2,0,0,0,0,-10,0,-2,-9,0,0,2,-2,-0.218338399189463,-0.456330749354005,0.0984746392383394,-0.213469735720375,-0.387434554973822,0.778947368421053,-0.979406919275124,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","H:Y",3.19420858638167,4.47975895465189e-07,0.632848408547862,5.04735185115046,8.04148719104289,105.368248724156,1.38722716584297,1.45797891284227e-09,8.83624875729546,6.89001106760784,131.337835841673,8.32938806400108e-13,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERR2516490","ERR2516490","lineage4.3.3","pe","Peru","pnca_p.his51arg","A","B","HIS","HA51","pnca_complex.pdb"
|
|
"H51R","L4","PZA","H","H51",51,"R",NA,"MDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",5.661,-0.862,-1.766,2.7037,-1.252,-1.48,74,85,-1.189,9,9,1,0.0044642857142857,"strand",1.36666666666667,6.97,0.001293661060802,24.3908629441624,24.3908627908724,24.3817411979725,51.2029377973759,-32,-2,0,0,-2,0,0,0,0,0,0,2,-2,0,0,0,0,-10,0,-2,-9,0,0,2,-2,-0.218338399189463,-0.456330749354005,0.0984746392383394,-0.213469735720375,-0.387434554973822,0.778947368421053,-0.979406919275124,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","H:Y",3.19420858638167,4.47975895465189e-07,0.632848408547862,5.04735185115046,8.04148719104289,105.368248724156,1.38722716584297,1.45797891284227e-09,8.83624875729546,6.89001106760784,131.337835841673,8.32938806400108e-13,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERR751631","ERR751631","lineage4.3.3","pe","","pnca_p.his51arg","A","B","HIS","HA51","pnca_complex.pdb"
|
|
"H51R","L4","PZA","H","H51",51,"R",NA,"MDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",5.661,-0.862,-1.766,2.7037,-1.252,-1.48,74,85,-1.189,9,9,1,0.0044642857142857,"strand",1.36666666666667,6.97,0.001293661060802,24.3908629441624,24.3908627908724,24.3817411979725,51.2029377973759,-32,-2,0,0,-2,0,0,0,0,0,0,2,-2,0,0,0,0,-10,0,-2,-9,0,0,2,-2,-0.218338399189463,-0.456330749354005,0.0984746392383394,-0.213469735720375,-0.387434554973822,0.778947368421053,-0.979406919275124,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","H:Y",3.19420858638167,4.47975895465189e-07,0.632848408547862,5.04735185115046,8.04148719104289,105.368248724156,1.38722716584297,1.45797891284227e-09,8.83624875729546,6.89001106760784,131.337835841673,8.32938806400108e-13,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERR2510150","ERR2510150","lineage4.3.3","pe","Peru","pnca_p.his51arg","A","B","HIS","HA51","pnca_complex.pdb"
|
|
"H51R","L4","PZA","H","H51",51,"R",1,"MDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",5.661,-0.862,-1.766,2.7037,-1.252,-1.48,74,85,-1.189,9,9,1,0.0044642857142857,"strand",1.36666666666667,6.97,0.001293661060802,24.3908629441624,24.3908627908724,24.3817411979725,51.2029377973759,-32,-2,0,0,-2,0,0,0,0,0,0,2,-2,0,0,0,0,-10,0,-2,-9,0,0,2,-2,-0.218338399189463,-0.456330749354005,0.0984746392383394,-0.213469735720375,-0.387434554973822,0.778947368421053,-0.979406919275124,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","H:Y",3.19420858638167,4.47975895465189e-07,0.632848408547862,5.04735185115046,8.04148719104289,105.368248724156,1.38722716584297,1.45797891284227e-09,8.83624875729546,6.89001106760784,131.337835841673,8.32938806400108e-13,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERR2516540","ERR2516540","lineage4.3.3","pe","Peru","pnca_p.his51arg","A","B","HIS","HA51","pnca_complex.pdb"
|
|
"H51R","L4","PZA","H","H51",51,"R",NA,"MDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",5.661,-0.862,-1.766,2.7037,-1.252,-1.48,74,85,-1.189,9,9,1,0.0044642857142857,"strand",1.36666666666667,6.97,0.001293661060802,24.3908629441624,24.3908627908724,24.3817411979725,51.2029377973759,-32,-2,0,0,-2,0,0,0,0,0,0,2,-2,0,0,0,0,-10,0,-2,-9,0,0,2,-2,-0.218338399189463,-0.456330749354005,0.0984746392383394,-0.213469735720375,-0.387434554973822,0.778947368421053,-0.979406919275124,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","H:Y",3.19420858638167,4.47975895465189e-07,0.632848408547862,5.04735185115046,8.04148719104289,105.368248724156,1.38722716584297,1.45797891284227e-09,8.83624875729546,6.89001106760784,131.337835841673,8.32938806400108e-13,"lineage4","dr_mutations_pyrazinamide","ARG",0,"SRS797387","SRR1723925","lineage4.5","cn","China:Zhejiang","pnca_p.his51arg","A","B","HIS","HA51","pnca_complex.pdb"
|
|
"H51R","L4","PZA","H","H51",51,"R",NA,"MDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",5.661,-0.862,-1.766,2.7037,-1.252,-1.48,74,85,-1.189,9,9,1,0.0044642857142857,"strand",1.36666666666667,6.97,0.001293661060802,24.3908629441624,24.3908627908724,24.3817411979725,51.2029377973759,-32,-2,0,0,-2,0,0,0,0,0,0,2,-2,0,0,0,0,-10,0,-2,-9,0,0,2,-2,-0.218338399189463,-0.456330749354005,0.0984746392383394,-0.213469735720375,-0.387434554973822,0.778947368421053,-0.979406919275124,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","H:Y",3.19420858638167,4.47975895465189e-07,0.632848408547862,5.04735185115046,8.04148719104289,105.368248724156,1.38722716584297,1.45797891284227e-09,8.83624875729546,6.89001106760784,131.337835841673,8.32938806400108e-13,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERR779922","ERR779922","lineage4.3.3","pe","","pnca_p.his51arg","A","B","HIS","HA51","pnca_complex.pdb"
|
|
"H51R","L4","PZA","H","H51",51,"R",NA,"MDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",5.661,-0.862,-1.766,2.7037,-1.252,-1.48,74,85,-1.189,9,9,1,0.0044642857142857,"strand",1.36666666666667,6.97,0.001293661060802,24.3908629441624,24.3908627908724,24.3817411979725,51.2029377973759,-32,-2,0,0,-2,0,0,0,0,0,0,2,-2,0,0,0,0,-10,0,-2,-9,0,0,2,-2,-0.218338399189463,-0.456330749354005,0.0984746392383394,-0.213469735720375,-0.387434554973822,0.778947368421053,-0.979406919275124,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","H:Y",3.19420858638167,4.47975895465189e-07,0.632848408547862,5.04735185115046,8.04148719104289,105.368248724156,1.38722716584297,1.45797891284227e-09,8.83624875729546,6.89001106760784,131.337835841673,8.32938806400108e-13,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERR751406","ERR751406","lineage4.3.3","pe","","pnca_p.his51arg","A","B","HIS","HA51","pnca_complex.pdb"
|
|
"H51R","L4","PZA","H","H51",51,"R",NA,"MDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",5.661,-0.862,-1.766,2.7037,-1.252,-1.48,74,85,-1.189,9,9,1,0.0044642857142857,"strand",1.36666666666667,6.97,0.001293661060802,24.3908629441624,24.3908627908724,24.3817411979725,51.2029377973759,-32,-2,0,0,-2,0,0,0,0,0,0,2,-2,0,0,0,0,-10,0,-2,-9,0,0,2,-2,-0.218338399189463,-0.456330749354005,0.0984746392383394,-0.213469735720375,-0.387434554973822,0.778947368421053,-0.979406919275124,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","H:Y",3.19420858638167,4.47975895465189e-07,0.632848408547862,5.04735185115046,8.04148719104289,105.368248724156,1.38722716584297,1.45797891284227e-09,8.83624875729546,6.89001106760784,131.337835841673,8.32938806400108e-13,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERR751621","ERR751621","lineage4.3.3","pe","","pnca_p.his51arg","A","B","HIS","HA51","pnca_complex.pdb"
|
|
"H51R","L4","PZA","H","H51",51,"R",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",5.661,-0.862,-1.766,2.7037,-1.252,-1.48,74,85,-1.189,9,9,1,0.0044642857142857,"strand",1.36666666666667,6.97,0.001293661060802,24.3908629441624,24.3908627908724,24.3817411979725,51.2029377973759,-32,-2,0,0,-2,0,0,0,0,0,0,2,-2,0,0,0,0,-10,0,-2,-9,0,0,2,-2,-0.218338399189463,-0.456330749354005,0.0984746392383394,-0.213469735720375,-0.387434554973822,0.778947368421053,-0.979406919275124,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","H:Y",3.19420858638167,4.47975895465189e-07,0.632848408547862,5.04735185115046,8.04148719104289,105.368248724156,1.38722716584297,1.45797891284227e-09,8.83624875729546,6.89001106760784,131.337835841673,8.32938806400108e-13,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERR751354","ERR751354","lineage4.3.3","pe","","pnca_p.his51arg","A","B","HIS","HA51","pnca_complex.pdb"
|
|
"H51R","L4","PZA","H","H51",51,"R",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",5.661,-0.862,-1.766,2.7037,-1.252,-1.48,74,85,-1.189,9,9,1,0.0044642857142857,"strand",1.36666666666667,6.97,0.001293661060802,24.3908629441624,24.3908627908724,24.3817411979725,51.2029377973759,-32,-2,0,0,-2,0,0,0,0,0,0,2,-2,0,0,0,0,-10,0,-2,-9,0,0,2,-2,-0.218338399189463,-0.456330749354005,0.0984746392383394,-0.213469735720375,-0.387434554973822,0.778947368421053,-0.979406919275124,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","H:Y",3.19420858638167,4.47975895465189e-07,0.632848408547862,5.04735185115046,8.04148719104289,105.368248724156,1.38722716584297,1.45797891284227e-09,8.83624875729546,6.89001106760784,131.337835841673,8.32938806400108e-13,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERR1193900","ERR1193900","lineage4.3.3","tm","Turkmenistan","pnca_p.his51arg","A","B","HIS","HA51","pnca_complex.pdb"
|
|
"H51R","L4","PZA","H","H51",51,"R",NA,"MDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",5.661,-0.862,-1.766,2.7037,-1.252,-1.48,74,85,-1.189,9,9,1,0.0044642857142857,"strand",1.36666666666667,6.97,0.001293661060802,24.3908629441624,24.3908627908724,24.3817411979725,51.2029377973759,-32,-2,0,0,-2,0,0,0,0,0,0,2,-2,0,0,0,0,-10,0,-2,-9,0,0,2,-2,-0.218338399189463,-0.456330749354005,0.0984746392383394,-0.213469735720375,-0.387434554973822,0.778947368421053,-0.979406919275124,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","H:Y",3.19420858638167,4.47975895465189e-07,0.632848408547862,5.04735185115046,8.04148719104289,105.368248724156,1.38722716584297,1.45797891284227e-09,8.83624875729546,6.89001106760784,131.337835841673,8.32938806400108e-13,"lineage4","dr_mutations_pyrazinamide","ARG",0,"SRR7517768","SRR7517768","lineage4.3.3","pe","Peru","pnca_p.his51arg","A","B","HIS","HA51","pnca_complex.pdb"
|
|
"H51R","L4","PZA","H","H51",51,"R",NA,"MDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",5.661,-0.862,-1.766,2.7037,-1.252,-1.48,74,85,-1.189,9,9,1,0.0044642857142857,"strand",1.36666666666667,6.97,0.001293661060802,24.3908629441624,24.3908627908724,24.3817411979725,51.2029377973759,-32,-2,0,0,-2,0,0,0,0,0,0,2,-2,0,0,0,0,-10,0,-2,-9,0,0,2,-2,-0.218338399189463,-0.456330749354005,0.0984746392383394,-0.213469735720375,-0.387434554973822,0.778947368421053,-0.979406919275124,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","H:Y",3.19420858638167,4.47975895465189e-07,0.632848408547862,5.04735185115046,8.04148719104289,105.368248724156,1.38722716584297,1.45797891284227e-09,8.83624875729546,6.89001106760784,131.337835841673,8.32938806400108e-13,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERR775374","ERR775374","lineage4.3.3","pe","","pnca_p.his51arg","A","B","HIS","HA51","pnca_complex.pdb"
|
|
"H51R","L4","PZA","H","H51",51,"R",NA,"MDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",5.661,-0.862,-1.766,2.7037,-1.252,-1.48,74,85,-1.189,9,9,1,0.0044642857142857,"strand",1.36666666666667,6.97,0.001293661060802,24.3908629441624,24.3908627908724,24.3817411979725,51.2029377973759,-32,-2,0,0,-2,0,0,0,0,0,0,2,-2,0,0,0,0,-10,0,-2,-9,0,0,2,-2,-0.218338399189463,-0.456330749354005,0.0984746392383394,-0.213469735720375,-0.387434554973822,0.778947368421053,-0.979406919275124,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","H:Y",3.19420858638167,4.47975895465189e-07,0.632848408547862,5.04735185115046,8.04148719104289,105.368248724156,1.38722716584297,1.45797891284227e-09,8.83624875729546,6.89001106760784,131.337835841673,8.32938806400108e-13,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERR3276176","ERR3276176","lineage4.3.3","nl","Netherlands","pnca_p.his51arg","A","B","HIS","HA51","pnca_complex.pdb"
|
|
"H51R","L2","PZA","H","H51",51,"R",NA,"XDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",5.661,-0.862,-1.766,2.7037,-1.252,-1.48,74,85,-1.189,9,9,1,0.0044642857142857,"strand",1.36666666666667,6.97,0.001293661060802,24.3908629441624,24.3908627908724,24.3817411979725,51.2029377973759,-32,-2,0,0,-2,0,0,0,0,0,0,2,-2,0,0,0,0,-10,0,-2,-9,0,0,2,-2,-0.218338399189463,-0.456330749354005,0.0984746392383394,-0.213469735720375,-0.387434554973822,0.778947368421053,-0.979406919275124,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","H:Y",3.19420858638167,4.47975895465189e-07,0.632848408547862,5.04735185115046,8.04148719104289,105.368248724156,1.38722716584297,1.45797891284227e-09,8.83624875729546,6.89001106760784,131.337835841673,8.32938806400108e-13,"lineage2","dr_mutations_pyrazinamide","ARG",0,"SRR6280174","SRR6280174","lineage2.2.1","cn","China","pnca_p.his51arg","A","B","HIS","HA51","pnca_complex.pdb"
|
|
"H51R","L4","PZA","H","H51",51,"R",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",5.661,-0.862,-1.766,2.7037,-1.252,-1.48,74,85,-1.189,9,9,1,0.0044642857142857,"strand",1.36666666666667,6.97,0.001293661060802,24.3908629441624,24.3908627908724,24.3817411979725,51.2029377973759,-32,-2,0,0,-2,0,0,0,0,0,0,2,-2,0,0,0,0,-10,0,-2,-9,0,0,2,-2,-0.218338399189463,-0.456330749354005,0.0984746392383394,-0.213469735720375,-0.387434554973822,0.778947368421053,-0.979406919275124,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","H:Y",3.19420858638167,4.47975895465189e-07,0.632848408547862,5.04735185115046,8.04148719104289,105.368248724156,1.38722716584297,1.45797891284227e-09,8.83624875729546,6.89001106760784,131.337835841673,8.32938806400108e-13,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERR751619","ERR751619","lineage4.3.3","pe","","pnca_p.his51arg","A","B","HIS","HA51","pnca_complex.pdb"
|
|
"H51R","L4","PZA","H","H51",51,"R",1,"Pre-XDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",5.661,-0.862,-1.766,2.7037,-1.252,-1.48,74,85,-1.189,9,9,1,0.0044642857142857,"strand",1.36666666666667,6.97,0.001293661060802,24.3908629441624,24.3908627908724,24.3817411979725,51.2029377973759,-32,-2,0,0,-2,0,0,0,0,0,0,2,-2,0,0,0,0,-10,0,-2,-9,0,0,2,-2,-0.218338399189463,-0.456330749354005,0.0984746392383394,-0.213469735720375,-0.387434554973822,0.778947368421053,-0.979406919275124,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","H:Y",3.19420858638167,4.47975895465189e-07,0.632848408547862,5.04735185115046,8.04148719104289,105.368248724156,1.38722716584297,1.45797891284227e-09,8.83624875729546,6.89001106760784,131.337835841673,8.32938806400108e-13,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERR2516538","ERR2516538","lineage4.3.3","pe","Peru","pnca_p.his51arg","A","B","HIS","HA51","pnca_complex.pdb"
|
|
"H51R","L4","PZA","H","H51",51,"R",NA,"Pre-MDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",5.661,-0.862,-1.766,2.7037,-1.252,-1.48,74,85,-1.189,9,9,1,0.0044642857142857,"strand",1.36666666666667,6.97,0.001293661060802,24.3908629441624,24.3908627908724,24.3817411979725,51.2029377973759,-32,-2,0,0,-2,0,0,0,0,0,0,2,-2,0,0,0,0,-10,0,-2,-9,0,0,2,-2,-0.218338399189463,-0.456330749354005,0.0984746392383394,-0.213469735720375,-0.387434554973822,0.778947368421053,-0.979406919275124,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","H:Y",3.19420858638167,4.47975895465189e-07,0.632848408547862,5.04735185115046,8.04148719104289,105.368248724156,1.38722716584297,1.45797891284227e-09,8.83624875729546,6.89001106760784,131.337835841673,8.32938806400108e-13,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERR779855","ERR779855","lineage4.3.3","pe","","pnca_p.his51arg","A","B","HIS","HA51","pnca_complex.pdb"
|
|
"H51R","L2","PZA","H","H51",51,"R",NA,"XDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",5.661,-0.862,-1.766,2.7037,-1.252,-1.48,74,85,-1.189,9,9,1,0.0044642857142857,"strand",1.36666666666667,6.97,0.001293661060802,24.3908629441624,24.3908627908724,24.3817411979725,51.2029377973759,-32,-2,0,0,-2,0,0,0,0,0,0,2,-2,0,0,0,0,-10,0,-2,-9,0,0,2,-2,-0.218338399189463,-0.456330749354005,0.0984746392383394,-0.213469735720375,-0.387434554973822,0.778947368421053,-0.979406919275124,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","H:Y",3.19420858638167,4.47975895465189e-07,0.632848408547862,5.04735185115046,8.04148719104289,105.368248724156,1.38722716584297,1.45797891284227e-09,8.83624875729546,6.89001106760784,131.337835841673,8.32938806400108e-13,"lineage2","dr_mutations_pyrazinamide","ARG",0,"SAMN03653263,SRS935995","SRR2024961","lineage2.2.1","cn","China","pnca_p.his51arg","A","B","HIS","HA51","pnca_complex.pdb"
|
|
"H51R","L4","PZA","H","H51",51,"R",NA,"MDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",5.661,-0.862,-1.766,2.7037,-1.252,-1.48,74,85,-1.189,9,9,1,0.0044642857142857,"strand",1.36666666666667,6.97,0.001293661060802,24.3908629441624,24.3908627908724,24.3817411979725,51.2029377973759,-32,-2,0,0,-2,0,0,0,0,0,0,2,-2,0,0,0,0,-10,0,-2,-9,0,0,2,-2,-0.218338399189463,-0.456330749354005,0.0984746392383394,-0.213469735720375,-0.387434554973822,0.778947368421053,-0.979406919275124,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","H:Y",3.19420858638167,4.47975895465189e-07,0.632848408547862,5.04735185115046,8.04148719104289,105.368248724156,1.38722716584297,1.45797891284227e-09,8.83624875729546,6.89001106760784,131.337835841673,8.32938806400108e-13,"lineage4","dr_mutations_pyrazinamide","ARG",0,"SRR7517767","SRR7517767","lineage4.3.3","pe","Peru","pnca_p.his51arg","A","B","HIS","HA51","pnca_complex.pdb"
|
|
"H51R","L4","PZA","H","H51",51,"R",1,"Pre-XDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",5.661,-0.862,-1.766,2.7037,-1.252,-1.48,74,85,-1.189,9,9,1,0.0044642857142857,"strand",1.36666666666667,6.97,0.001293661060802,24.3908629441624,24.3908627908724,24.3817411979725,51.2029377973759,-32,-2,0,0,-2,0,0,0,0,0,0,2,-2,0,0,0,0,-10,0,-2,-9,0,0,2,-2,-0.218338399189463,-0.456330749354005,0.0984746392383394,-0.213469735720375,-0.387434554973822,0.778947368421053,-0.979406919275124,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","H:Y",3.19420858638167,4.47975895465189e-07,0.632848408547862,5.04735185115046,8.04148719104289,105.368248724156,1.38722716584297,1.45797891284227e-09,8.83624875729546,6.89001106760784,131.337835841673,8.32938806400108e-13,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERR2516457","ERR2516457","lineage4.3.3","pe","Peru","pnca_p.his51arg","A","B","HIS","HA51","pnca_complex.pdb"
|
|
"H51R","L4","PZA","H","H51",51,"R",0,"Pre-XDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",5.661,-0.862,-1.766,2.7037,-1.252,-1.48,74,85,-1.189,9,9,1,0.0044642857142857,"strand",1.36666666666667,6.97,0.001293661060802,24.3908629441624,24.3908627908724,24.3817411979725,51.2029377973759,-32,-2,0,0,-2,0,0,0,0,0,0,2,-2,0,0,0,0,-10,0,-2,-9,0,0,2,-2,-0.218338399189463,-0.456330749354005,0.0984746392383394,-0.213469735720375,-0.387434554973822,0.778947368421053,-0.979406919275124,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","H:Y",3.19420858638167,4.47975895465189e-07,0.632848408547862,5.04735185115046,8.04148719104289,105.368248724156,1.38722716584297,1.45797891284227e-09,8.83624875729546,6.89001106760784,131.337835841673,8.32938806400108e-13,"lineage4","dr_mutations_pyrazinamide","ARG",0,"SAMEA2534331,ERS457733","ERR551984_ERR551985","lineage4.3.3","uz","Nukus","pnca_p.his51arg","A","B","HIS","HA51","pnca_complex.pdb"
|
|
"H51R","L4","PZA","H","H51",51,"R",NA,"MDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",5.661,-0.862,-1.766,2.7037,-1.252,-1.48,74,85,-1.189,9,9,1,0.0044642857142857,"strand",1.36666666666667,6.97,0.001293661060802,24.3908629441624,24.3908627908724,24.3817411979725,51.2029377973759,-32,-2,0,0,-2,0,0,0,0,0,0,2,-2,0,0,0,0,-10,0,-2,-9,0,0,2,-2,-0.218338399189463,-0.456330749354005,0.0984746392383394,-0.213469735720375,-0.387434554973822,0.778947368421053,-0.979406919275124,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","H:Y",3.19420858638167,4.47975895465189e-07,0.632848408547862,5.04735185115046,8.04148719104289,105.368248724156,1.38722716584297,1.45797891284227e-09,8.83624875729546,6.89001106760784,131.337835841673,8.32938806400108e-13,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERR751585","ERR751585","lineage4.3.3","pe","","pnca_p.his51arg","A","B","HIS","HA51","pnca_complex.pdb"
|
|
"H51R","L2","PZA","H","H51",51,"R",NA,"MDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",5.661,-0.862,-1.766,2.7037,-1.252,-1.48,74,85,-1.189,9,9,1,0.0044642857142857,"strand",1.36666666666667,6.97,0.001293661060802,24.3908629441624,24.3908627908724,24.3817411979725,51.2029377973759,-32,-2,0,0,-2,0,0,0,0,0,0,2,-2,0,0,0,0,-10,0,-2,-9,0,0,2,-2,-0.218338399189463,-0.456330749354005,0.0984746392383394,-0.213469735720375,-0.387434554973822,0.778947368421053,-0.979406919275124,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","H:Y",3.19420858638167,4.47975895465189e-07,0.632848408547862,5.04735185115046,8.04148719104289,105.368248724156,1.38722716584297,1.45797891284227e-09,8.83624875729546,6.89001106760784,131.337835841673,8.32938806400108e-13,"lineage2","dr_mutations_pyrazinamide","ARG",0,"SRS936023,SAMN03653282","SRR2024982","lineage2.2.1","cn","China","pnca_p.his51arg","A","B","HIS","HA51","pnca_complex.pdb"
|
|
"H51R","L4","PZA","H","H51",51,"R",NA,"MDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",5.661,-0.862,-1.766,2.7037,-1.252,-1.48,74,85,-1.189,9,9,1,0.0044642857142857,"strand",1.36666666666667,6.97,0.001293661060802,24.3908629441624,24.3908627908724,24.3817411979725,51.2029377973759,-32,-2,0,0,-2,0,0,0,0,0,0,2,-2,0,0,0,0,-10,0,-2,-9,0,0,2,-2,-0.218338399189463,-0.456330749354005,0.0984746392383394,-0.213469735720375,-0.387434554973822,0.778947368421053,-0.979406919275124,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","H:Y",3.19420858638167,4.47975895465189e-07,0.632848408547862,5.04735185115046,8.04148719104289,105.368248724156,1.38722716584297,1.45797891284227e-09,8.83624875729546,6.89001106760784,131.337835841673,8.32938806400108e-13,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERR751568","ERR751568","lineage4.3.3","pe","","pnca_p.his51arg","A","B","HIS","HA51","pnca_complex.pdb"
|
|
"H51R","L4","PZA","H","H51",51,"R",NA,"MDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",5.661,-0.862,-1.766,2.7037,-1.252,-1.48,74,85,-1.189,9,9,1,0.0044642857142857,"strand",1.36666666666667,6.97,0.001293661060802,24.3908629441624,24.3908627908724,24.3817411979725,51.2029377973759,-32,-2,0,0,-2,0,0,0,0,0,0,2,-2,0,0,0,0,-10,0,-2,-9,0,0,2,-2,-0.218338399189463,-0.456330749354005,0.0984746392383394,-0.213469735720375,-0.387434554973822,0.778947368421053,-0.979406919275124,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","H:Y",3.19420858638167,4.47975895465189e-07,0.632848408547862,5.04735185115046,8.04148719104289,105.368248724156,1.38722716584297,1.45797891284227e-09,8.83624875729546,6.89001106760784,131.337835841673,8.32938806400108e-13,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERR751578","ERR751578","lineage4.3.3","pe","","pnca_p.his51arg","A","B","HIS","HA51","pnca_complex.pdb"
|
|
"H51R","L4","PZA","H","H51",51,"R",NA,"MDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",5.661,-0.862,-1.766,2.7037,-1.252,-1.48,74,85,-1.189,9,9,1,0.0044642857142857,"strand",1.36666666666667,6.97,0.001293661060802,24.3908629441624,24.3908627908724,24.3817411979725,51.2029377973759,-32,-2,0,0,-2,0,0,0,0,0,0,2,-2,0,0,0,0,-10,0,-2,-9,0,0,2,-2,-0.218338399189463,-0.456330749354005,0.0984746392383394,-0.213469735720375,-0.387434554973822,0.778947368421053,-0.979406919275124,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","H:Y",3.19420858638167,4.47975895465189e-07,0.632848408547862,5.04735185115046,8.04148719104289,105.368248724156,1.38722716584297,1.45797891284227e-09,8.83624875729546,6.89001106760784,131.337835841673,8.32938806400108e-13,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERR2510169","ERR2510169","lineage4.3.3","pe","Peru","pnca_p.his51arg","A","B","HIS","HA51","pnca_complex.pdb"
|
|
"H51R","L4","PZA","H","H51",51,"R",NA,"MDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",5.661,-0.862,-1.766,2.7037,-1.252,-1.48,74,85,-1.189,9,9,1,0.0044642857142857,"strand",1.36666666666667,6.97,0.001293661060802,24.3908629441624,24.3908627908724,24.3817411979725,51.2029377973759,-32,-2,0,0,-2,0,0,0,0,0,0,2,-2,0,0,0,0,-10,0,-2,-9,0,0,2,-2,-0.218338399189463,-0.456330749354005,0.0984746392383394,-0.213469735720375,-0.387434554973822,0.778947368421053,-0.979406919275124,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","H:Y",3.19420858638167,4.47975895465189e-07,0.632848408547862,5.04735185115046,8.04148719104289,105.368248724156,1.38722716584297,1.45797891284227e-09,8.83624875729546,6.89001106760784,131.337835841673,8.32938806400108e-13,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERR751387","ERR751387","lineage4.3.3","pe","","pnca_p.his51arg","A","B","HIS","HA51","pnca_complex.pdb"
|
|
"H51R","L4","PZA","H","H51",51,"R",NA,"MDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",5.661,-0.862,-1.766,2.7037,-1.252,-1.48,74,85,-1.189,9,9,1,0.0044642857142857,"strand",1.36666666666667,6.97,0.001293661060802,24.3908629441624,24.3908627908724,24.3817411979725,51.2029377973759,-32,-2,0,0,-2,0,0,0,0,0,0,2,-2,0,0,0,0,-10,0,-2,-9,0,0,2,-2,-0.218338399189463,-0.456330749354005,0.0984746392383394,-0.213469735720375,-0.387434554973822,0.778947368421053,-0.979406919275124,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","H:Y",3.19420858638167,4.47975895465189e-07,0.632848408547862,5.04735185115046,8.04148719104289,105.368248724156,1.38722716584297,1.45797891284227e-09,8.83624875729546,6.89001106760784,131.337835841673,8.32938806400108e-13,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERR751372","ERR751372","lineage4.3.3","pe","","pnca_p.his51arg","A","B","HIS","HA51","pnca_complex.pdb"
|
|
"H51R","L4","PZA","H","H51",51,"R",NA,"MDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",5.661,-0.862,-1.766,2.7037,-1.252,-1.48,74,85,-1.189,9,9,1,0.0044642857142857,"strand",1.36666666666667,6.97,0.001293661060802,24.3908629441624,24.3908627908724,24.3817411979725,51.2029377973759,-32,-2,0,0,-2,0,0,0,0,0,0,2,-2,0,0,0,0,-10,0,-2,-9,0,0,2,-2,-0.218338399189463,-0.456330749354005,0.0984746392383394,-0.213469735720375,-0.387434554973822,0.778947368421053,-0.979406919275124,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","H:Y",3.19420858638167,4.47975895465189e-07,0.632848408547862,5.04735185115046,8.04148719104289,105.368248724156,1.38722716584297,1.45797891284227e-09,8.83624875729546,6.89001106760784,131.337835841673,8.32938806400108e-13,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERR751624","ERR751624","lineage4.3.3","pe","","pnca_p.his51arg","A","B","HIS","HA51","pnca_complex.pdb"
|
|
"H51R","L2","PZA","H","H51",51,"R",0,"Pre-XDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",5.661,-0.862,-1.766,2.7037,-1.252,-1.48,74,85,-1.189,9,9,1,0.0044642857142857,"strand",1.36666666666667,6.97,0.001293661060802,24.3908629441624,24.3908627908724,24.3817411979725,51.2029377973759,-32,-2,0,0,-2,0,0,0,0,0,0,2,-2,0,0,0,0,-10,0,-2,-9,0,0,2,-2,-0.218338399189463,-0.456330749354005,0.0984746392383394,-0.213469735720375,-0.387434554973822,0.778947368421053,-0.979406919275124,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","H:Y",3.19420858638167,4.47975895465189e-07,0.632848408547862,5.04735185115046,8.04148719104289,105.368248724156,1.38722716584297,1.45797891284227e-09,8.83624875729546,6.89001106760784,131.337835841673,8.32938806400108e-13,"lineage2","dr_mutations_pyrazinamide","ARG",0,"ERR137206,1250K-sc-2012-02-21T11:36:25Z-1364698","ERR137206","lineage2.2.1","ru","Russia,Samara","pnca_p.his51arg","A","B","HIS","HA51","pnca_complex.pdb"
|
|
"H51R","L2","PZA","H","H51",51,"R",1,"MDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",5.661,-0.862,-1.766,2.7037,-1.252,-1.48,74,85,-1.189,9,9,1,0.0044642857142857,"strand",1.36666666666667,6.97,0.001293661060802,24.3908629441624,24.3908627908724,24.3817411979725,51.2029377973759,-32,-2,0,0,-2,0,0,0,0,0,0,2,-2,0,0,0,0,-10,0,-2,-9,0,0,2,-2,-0.218338399189463,-0.456330749354005,0.0984746392383394,-0.213469735720375,-0.387434554973822,0.778947368421053,-0.979406919275124,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","H:Y",3.19420858638167,4.47975895465189e-07,0.632848408547862,5.04735185115046,8.04148719104289,105.368248724156,1.38722716584297,1.45797891284227e-09,8.83624875729546,6.89001106760784,131.337835841673,8.32938806400108e-13,"lineage2","dr_mutations_pyrazinamide","ARG",0,"ERR2510720","ERR2510720","lineage2.2.1","it","Italy","pnca_p.his51arg","A","B","HIS","HA51","pnca_complex.pdb"
|
|
"H51R","L4","PZA","H","H51",51,"R",NA,"MDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",5.661,-0.862,-1.766,2.7037,-1.252,-1.48,74,85,-1.189,9,9,1,0.0044642857142857,"strand",1.36666666666667,6.97,0.001293661060802,24.3908629441624,24.3908627908724,24.3817411979725,51.2029377973759,-32,-2,0,0,-2,0,0,0,0,0,0,2,-2,0,0,0,0,-10,0,-2,-9,0,0,2,-2,-0.218338399189463,-0.456330749354005,0.0984746392383394,-0.213469735720375,-0.387434554973822,0.778947368421053,-0.979406919275124,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","H:Y",3.19420858638167,4.47975895465189e-07,0.632848408547862,5.04735185115046,8.04148719104289,105.368248724156,1.38722716584297,1.45797891284227e-09,8.83624875729546,6.89001106760784,131.337835841673,8.32938806400108e-13,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERR2510165","ERR2510165","lineage4.3.3","pe","Peru","pnca_p.his51arg","A","B","HIS","HA51","pnca_complex.pdb"
|
|
"H51R","L4","PZA","H","H51",51,"R",NA,"MDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",5.661,-0.862,-1.766,2.7037,-1.252,-1.48,74,85,-1.189,9,9,1,0.0044642857142857,"strand",1.36666666666667,6.97,0.001293661060802,24.3908629441624,24.3908627908724,24.3817411979725,51.2029377973759,-32,-2,0,0,-2,0,0,0,0,0,0,2,-2,0,0,0,0,-10,0,-2,-9,0,0,2,-2,-0.218338399189463,-0.456330749354005,0.0984746392383394,-0.213469735720375,-0.387434554973822,0.778947368421053,-0.979406919275124,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","H:Y",3.19420858638167,4.47975895465189e-07,0.632848408547862,5.04735185115046,8.04148719104289,105.368248724156,1.38722716584297,1.45797891284227e-09,8.83624875729546,6.89001106760784,131.337835841673,8.32938806400108e-13,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERR779897","ERR779897","lineage4.3.3","pe","","pnca_p.his51arg","A","B","HIS","HA51","pnca_complex.pdb"
|
|
"H51R","L4","PZA","H","H51",51,"R",NA,"MDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",5.661,-0.862,-1.766,2.7037,-1.252,-1.48,74,85,-1.189,9,9,1,0.0044642857142857,"strand",1.36666666666667,6.97,0.001293661060802,24.3908629441624,24.3908627908724,24.3817411979725,51.2029377973759,-32,-2,0,0,-2,0,0,0,0,0,0,2,-2,0,0,0,0,-10,0,-2,-9,0,0,2,-2,-0.218338399189463,-0.456330749354005,0.0984746392383394,-0.213469735720375,-0.387434554973822,0.778947368421053,-0.979406919275124,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","H:Y",3.19420858638167,4.47975895465189e-07,0.632848408547862,5.04735185115046,8.04148719104289,105.368248724156,1.38722716584297,1.45797891284227e-09,8.83624875729546,6.89001106760784,131.337835841673,8.32938806400108e-13,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERR2179652","ERR2179652","lineage4.5","cn","China","pnca_p.his51arg","A","B","HIS","HA51","pnca_complex.pdb"
|
|
"H51R","L4","PZA","H","H51",51,"R",NA,"MDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",5.661,-0.862,-1.766,2.7037,-1.252,-1.48,74,85,-1.189,9,9,1,0.0044642857142857,"strand",1.36666666666667,6.97,0.001293661060802,24.3908629441624,24.3908627908724,24.3817411979725,51.2029377973759,-32,-2,0,0,-2,0,0,0,0,0,0,2,-2,0,0,0,0,-10,0,-2,-9,0,0,2,-2,-0.218338399189463,-0.456330749354005,0.0984746392383394,-0.213469735720375,-0.387434554973822,0.778947368421053,-0.979406919275124,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","H:Y",3.19420858638167,4.47975895465189e-07,0.632848408547862,5.04735185115046,8.04148719104289,105.368248724156,1.38722716584297,1.45797891284227e-09,8.83624875729546,6.89001106760784,131.337835841673,8.32938806400108e-13,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERR2510233","ERR2510233","lineage4.3.3","pe","Peru","pnca_p.his51arg","A","B","HIS","HA51","pnca_complex.pdb"
|
|
"H51R","L2","PZA","H","H51",51,"R",NA,"XDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",5.661,-0.862,-1.766,2.7037,-1.252,-1.48,74,85,-1.189,9,9,1,0.0044642857142857,"strand",1.36666666666667,6.97,0.001293661060802,24.3908629441624,24.3908627908724,24.3817411979725,51.2029377973759,-32,-2,0,0,-2,0,0,0,0,0,0,2,-2,0,0,0,0,-10,0,-2,-9,0,0,2,-2,-0.218338399189463,-0.456330749354005,0.0984746392383394,-0.213469735720375,-0.387434554973822,0.778947368421053,-0.979406919275124,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.178,"9:9","149/150","H:Y",3.19420858638167,4.47975895465189e-07,0.632848408547862,5.04735185115046,8.04148719104289,105.368248724156,1.38722716584297,1.45797891284227e-09,8.83624875729546,6.89001106760784,131.337835841673,8.32938806400108e-13,"lineage2","dr_mutations_pyrazinamide","ARG",0,"SAMN03653258,SRS936009","SRR2024955","lineage2.2.1","cn","China","pnca_p.his51arg","A","B","HIS","HA51","pnca_complex.pdb"
|
|
"H51Y","L4","PZA","H","H51",51,"Y",NA,"MDR","DM","hydrophobic","hydrophobic","basic","neutral","pos","polar",5.661,-2.046,0.122,-1.10156,-0.891,0.41,60,80,-1.189,9,9,1,0.0044642857142857,"strand",1.36666666666667,6.97,0.0002156101768003,9.70466975178797,9.70465898653051,9.70194990589383,2.29168245016684,-18,-6,0,0,-6,0,0,0,0,2,0,2,0,0,0,0,0,-4,0,2,-6,-2,0,4,-4,-0.518237082066869,0.103741496598639,-0.21178958701838,-0.151918158567775,0.230337078651685,0.631578947368421,-0.979406919275124,"Destabilising","Stabilising","Stabilising","Destabilising","Stabilising","effect",-1.221,-1.178,"9:9","149/150","H:Y",2.27260607808817,0.0634455902260897,1.22442760158496,1.8560559033024,0.929172866365331,208.881603005168,0.986980761010679,0.0776844925942494,1.10966566656461,0.504888890842109,570.372842410328,0.130068862702538,"lineage4","dr_mutations_pyrazinamide","TYR",0,"ERR2707212","ERR2707212","lineage4.3.3","cd","Democratic Republic of Congo","pnca_p.his51tyr","A","B","HIS","HA51","pnca_complex.pdb"
|
|
"H51Y","L4","PZA","H","H51",51,"Y",NA,"Pre-MDR","DM","hydrophobic","hydrophobic","basic","neutral","pos","polar",5.661,-2.046,0.122,-1.10156,-0.891,0.41,60,80,-1.189,9,9,1,0.0044642857142857,"strand",1.36666666666667,6.97,0.0002156101768003,9.70466975178797,9.70465898653051,9.70194990589383,2.29168245016684,-18,-6,0,0,-6,0,0,0,0,2,0,2,0,0,0,0,0,-4,0,2,-6,-2,0,4,-4,-0.518237082066869,0.103741496598639,-0.21178958701838,-0.151918158567775,0.230337078651685,0.631578947368421,-0.979406919275124,"Destabilising","Stabilising","Stabilising","Destabilising","Stabilising","effect",-1.221,-1.178,"9:9","149/150","H:Y",2.27260607808817,0.0634455902260897,1.22442760158496,1.8560559033024,0.929172866365331,208.881603005168,0.986980761010679,0.0776844925942494,1.10966566656461,0.504888890842109,570.372842410328,0.130068862702538,"lineage4","dr_mutations_pyrazinamide","TYR",0,"ERR2706966","ERR2706966","lineage4.6.1.2;lineage4.3.3","cd","Democratic Republic of Congo","pnca_p.his51tyr","A","B","HIS","HA51","pnca_complex.pdb"
|
|
"H51Y","L2","PZA","H","H51",51,"Y",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","basic","neutral","pos","polar",5.661,-2.046,0.122,-1.10156,-0.891,0.41,60,80,-1.189,9,9,1,0.0044642857142857,"strand",1.36666666666667,6.97,0.0002156101768003,9.70466975178797,9.70465898653051,9.70194990589383,2.29168245016684,-18,-6,0,0,-6,0,0,0,0,2,0,2,0,0,0,0,0,-4,0,2,-6,-2,0,4,-4,-0.518237082066869,0.103741496598639,-0.21178958701838,-0.151918158567775,0.230337078651685,0.631578947368421,-0.979406919275124,"Destabilising","Stabilising","Stabilising","Destabilising","Stabilising","effect",-1.221,-1.178,"9:9","149/150","H:Y",2.27260607808817,0.0634455902260897,1.22442760158496,1.8560559033024,0.929172866365331,208.881603005168,0.986980761010679,0.0776844925942494,1.10966566656461,0.504888890842109,570.372842410328,0.130068862702538,"lineage2","dr_mutations_pyrazinamide","TYR",0,"1710K-sc-2012-02-21T11:37:05Z-1364757,ERR137265","ERR137265","lineage2.2.1","ru","Russia","pnca_p.his51tyr","A","B","HIS","HA51","pnca_complex.pdb"
|
|
"H51Y","L2","PZA","H","H51",51,"Y",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","basic","neutral","pos","polar",5.661,-2.046,0.122,-1.10156,-0.891,0.41,60,80,-1.189,9,9,1,0.0044642857142857,"strand",1.36666666666667,6.97,0.0002156101768003,9.70466975178797,9.70465898653051,9.70194990589383,2.29168245016684,-18,-6,0,0,-6,0,0,0,0,2,0,2,0,0,0,0,0,-4,0,2,-6,-2,0,4,-4,-0.518237082066869,0.103741496598639,-0.21178958701838,-0.151918158567775,0.230337078651685,0.631578947368421,-0.979406919275124,"Destabilising","Stabilising","Stabilising","Destabilising","Stabilising","effect",-1.221,-1.178,"9:9","149/150","H:Y",2.27260607808817,0.0634455902260897,1.22442760158496,1.8560559033024,0.929172866365331,208.881603005168,0.986980761010679,0.0776844925942494,1.10966566656461,0.504888890842109,570.372842410328,0.130068862702538,"lineage2","dr_mutations_pyrazinamide","TYR",0,"ERR2510838","ERR2510838","lineage2.2.1","it","Italy","pnca_p.his51tyr","A","B","HIS","HA51","pnca_complex.pdb"
|
|
"H51Y","L5","PZA","H","H51",51,"Y",NA,"MDR","DM","hydrophobic","hydrophobic","basic","neutral","pos","polar",5.661,-2.046,0.122,-1.10156,-0.891,0.41,60,80,-1.189,9,9,1,0.0044642857142857,"strand",1.36666666666667,6.97,0.0002156101768003,9.70466975178797,9.70465898653051,9.70194990589383,2.29168245016684,-18,-6,0,0,-6,0,0,0,0,2,0,2,0,0,0,0,0,-4,0,2,-6,-2,0,4,-4,-0.518237082066869,0.103741496598639,-0.21178958701838,-0.151918158567775,0.230337078651685,0.631578947368421,-0.979406919275124,"Destabilising","Stabilising","Stabilising","Destabilising","Stabilising","effect",-1.221,-1.178,"9:9","149/150","H:Y",2.27260607808817,0.0634455902260897,1.22442760158496,1.8560559033024,0.929172866365331,208.881603005168,0.986980761010679,0.0776844925942494,1.10966566656461,0.504888890842109,570.372842410328,0.130068862702538,"lineage5","dr_mutations_pyrazinamide","TYR",0,"ERR702408","ERR702408","lineage5","gh","Ghana","pnca_p.his51tyr","A","B","HIS","HA51","pnca_complex.pdb"
|
|
"H51Y","L5","PZA","H","H51",51,"Y",NA,"MDR","DM","hydrophobic","hydrophobic","basic","neutral","pos","polar",5.661,-2.046,0.122,-1.10156,-0.891,0.41,60,80,-1.189,9,9,1,0.0044642857142857,"strand",1.36666666666667,6.97,0.0002156101768003,9.70466975178797,9.70465898653051,9.70194990589383,2.29168245016684,-18,-6,0,0,-6,0,0,0,0,2,0,2,0,0,0,0,0,-4,0,2,-6,-2,0,4,-4,-0.518237082066869,0.103741496598639,-0.21178958701838,-0.151918158567775,0.230337078651685,0.631578947368421,-0.979406919275124,"Destabilising","Stabilising","Stabilising","Destabilising","Stabilising","effect",-1.221,-1.178,"9:9","149/150","H:Y",2.27260607808817,0.0634455902260897,1.22442760158496,1.8560559033024,0.929172866365331,208.881603005168,0.986980761010679,0.0776844925942494,1.10966566656461,0.504888890842109,570.372842410328,0.130068862702538,"lineage5","dr_mutations_pyrazinamide","TYR",0,"ERR751314","ERR751314","lineage5","gh","Ghana","pnca_p.his51tyr","A","B","HIS","HA51","pnca_complex.pdb"
|
|
"H51Y","L2","PZA","H","H51",51,"Y",1,"Pre-MDR","DM","hydrophobic","hydrophobic","basic","neutral","pos","polar",5.661,-2.046,0.122,-1.10156,-0.891,0.41,60,80,-1.189,9,9,1,0.0044642857142857,"strand",1.36666666666667,6.97,0.0002156101768003,9.70466975178797,9.70465898653051,9.70194990589383,2.29168245016684,-18,-6,0,0,-6,0,0,0,0,2,0,2,0,0,0,0,0,-4,0,2,-6,-2,0,4,-4,-0.518237082066869,0.103741496598639,-0.21178958701838,-0.151918158567775,0.230337078651685,0.631578947368421,-0.979406919275124,"Destabilising","Stabilising","Stabilising","Destabilising","Stabilising","effect",-1.221,-1.178,"9:9","149/150","H:Y",2.27260607808817,0.0634455902260897,1.22442760158496,1.8560559033024,0.929172866365331,208.881603005168,0.986980761010679,0.0776844925942494,1.10966566656461,0.504888890842109,570.372842410328,0.130068862702538,"lineage2","dr_mutations_pyrazinamide","TYR",0,"MDR_23264","SRR6824363","lineage2.2.1","cn","China: Fucheng District, Mianyang City, Sichuan Province","pnca_p.his51tyr","A","B","HIS","HA51","pnca_complex.pdb"
|
|
"H51Y","L4","PZA","H","H51",51,"Y",0,"MDR","DM","hydrophobic","hydrophobic","basic","neutral","pos","polar",5.661,-2.046,0.122,-1.10156,-0.891,0.41,60,80,-1.189,9,9,1,0.0044642857142857,"strand",1.36666666666667,6.97,0.0002156101768003,9.70466975178797,9.70465898653051,9.70194990589383,2.29168245016684,-18,-6,0,0,-6,0,0,0,0,2,0,2,0,0,0,0,0,-4,0,2,-6,-2,0,4,-4,-0.518237082066869,0.103741496598639,-0.21178958701838,-0.151918158567775,0.230337078651685,0.631578947368421,-0.979406919275124,"Destabilising","Stabilising","Stabilising","Destabilising","Stabilising","effect",-1.221,-1.178,"9:9","149/150","H:Y",2.27260607808817,0.0634455902260897,1.22442760158496,1.8560559033024,0.929172866365331,208.881603005168,0.986980761010679,0.0776844925942494,1.10966566656461,0.504888890842109,570.372842410328,0.130068862702538,"lineage4","dr_mutations_pyrazinamide","TYR",0,"SAMN02053746","SRR833106_SRR833037","lineage4.3.3","za","South Africa","pnca_p.his51tyr","A","B","HIS","HA51","pnca_complex.pdb"
|
|
"H51Y","L4","PZA","H","H51",51,"Y",NA,"MDR","DM","hydrophobic","hydrophobic","basic","neutral","pos","polar",5.661,-2.046,0.122,-1.10156,-0.891,0.41,60,80,-1.189,9,9,1,0.0044642857142857,"strand",1.36666666666667,6.97,0.0002156101768003,9.70466975178797,9.70465898653051,9.70194990589383,2.29168245016684,-18,-6,0,0,-6,0,0,0,0,2,0,2,0,0,0,0,0,-4,0,2,-6,-2,0,4,-4,-0.518237082066869,0.103741496598639,-0.21178958701838,-0.151918158567775,0.230337078651685,0.631578947368421,-0.979406919275124,"Destabilising","Stabilising","Stabilising","Destabilising","Stabilising","effect",-1.221,-1.178,"9:9","149/150","H:Y",2.27260607808817,0.0634455902260897,1.22442760158496,1.8560559033024,0.929172866365331,208.881603005168,0.986980761010679,0.0776844925942494,1.10966566656461,0.504888890842109,570.372842410328,0.130068862702538,"lineage4","dr_mutations_pyrazinamide","TYR",0,"SAMN02567719","SRR1166086","lineage4.1.2.1","ro","Romania","pnca_p.his51tyr","A","B","HIS","HA51","pnca_complex.pdb"
|
|
"H51Y","L2;L4","PZA","H","H51",51,"Y",1,"Pre-XDR","DM","hydrophobic","hydrophobic","basic","neutral","pos","polar",5.661,-2.046,0.122,-1.10156,-0.891,0.41,60,80,-1.189,9,9,1,0.0044642857142857,"strand",1.36666666666667,6.97,0.0002156101768003,9.70466975178797,9.70465898653051,9.70194990589383,2.29168245016684,-18,-6,0,0,-6,0,0,0,0,2,0,2,0,0,0,0,0,-4,0,2,-6,-2,0,4,-4,-0.518237082066869,0.103741496598639,-0.21178958701838,-0.151918158567775,0.230337078651685,0.631578947368421,-0.979406919275124,"Destabilising","Stabilising","Stabilising","Destabilising","Stabilising","effect",-1.221,-1.178,"9:9","149/150","H:Y",2.27260607808817,0.0634455902260897,1.22442760158496,1.8560559033024,0.929172866365331,208.881603005168,0.986980761010679,0.0776844925942494,1.10966566656461,0.504888890842109,570.372842410328,0.130068862702538,"lineage2;lineage4","dr_mutations_pyrazinamide","TYR",0,"ERR2516648","ERR2516648","lineage4;lineage2.2.1","pe","Peru","pnca_p.his51tyr","A","B","HIS","HA51","pnca_complex.pdb"
|
|
"I52T","L4","PZA","I","I52",52,"T",NA,"Sensitive","OM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",12.353,0.529,-1.196,0.950846,-1.262,-1.33,26,63,-0.518,7,7,82,0.416243654822335,"loop",-0.733333333333333,4.09,NA,NA,NA,NA,NA,6,0,0,0,0,0,0,0,0,-2,0,0,-2,0,0,0,0,-1,0,-3,0,0,0,0,-2,0.237219730941704,-0.309043927648579,0.0346318810597397,-0.215174765558397,-0.348167539267016,0.273684210526316,-0.42668863261944,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.674,-0.411,"7:7","149/150","N:L:V:I:S:T:P:D",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage4","other_mutations_pyrazinamide","THR",0,"ERR1465772","ERR1465772","lineage4.1.2.1","ch","Switzerland","pnca_p.ile52thr","A","S","ILE","IA52","pnca_complex.pdb"
|
|
"D53E","L4","PZA","D","D53",53,"E",0,"Sensitive","OM","hydrophilic","hydrophilic","acidic","acidic","neg","neg",13.16,-0.123,-0.145,0.906346,-0.467,0.14,-39,66,0.498,3,3,103,0.533678756476684,"loop",-0.2,3.83,7.18700589334483e-05,2.42412778478352,0.0001249735077034,0,1.03410070803344e-29,-6,2,0,0,2,0,0,0,0,0,0,0,0,0,0,0,0,-1,0,-1,0,-2,0,-2,0,-0.0311550151975683,-0.0374677002583979,0.0330110941950335,-0.0796248934356351,0.0786516853932584,-0.419354838709677,0.159615384615385,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","neutral",0.225,0.59,"4:3","148/150","D:P:S:G:A:I:R:L:N:V:Q:E:H",-8.9874087814964,0.940032862253633,119.468044435491,-0.0752285585987752,NA,4692673.51081297,0.384555509373631,1,0,0,188.544222231268,0.999999999999997,"lineage4","other_mutations_pyrazinamide","GLU",0,"SAMN03648619,SRR2101372","SRR2101372","lineage4.3.4.2.1","","","pnca_p.asp53glu","A","-","ASP","DA53","pnca_complex.pdb"
|
|
"P54A","L2","PZA","P","P54",54,"A",NA,"MDR","OM","hydrophilic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.765,-1.785,-1.416,2.25796,-1.236,-1.58,25,63,-0.129,5,5,8,0.050314465408805,"loop",-1.83333333333333,4.91,7.18700589334483e-05,2.42412778478352,0.0001249735077034,0,1.03410070803344e-29,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-1,0,-1,0,0,0,0,1,-0.452127659574468,-0.365891472868217,0.0822398181804938,-0.21074168797954,-0.413612565445026,0.263157894736842,-0.106260296540362,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","148/150","Q:E:H:K:V:N:P:A:G:S:D",-8.98740878149641,0.940032862253633,119.468044435491,-0.0752285585987755,NA,4692673.51081266,0.384555509373631,1,0,0,188.544222231268,0.999999999999997,"lineage2","other_mutations_pyrazinamide","ALA",0,"SRR671771,BGI_GZ10115","SRR671771","lineage2.2.1","cn","China","pnca_p.pro54ala","A","-","PRO","PA54","pnca_complex.pdb"
|
|
"P54A","L2","PZA","P","P54",54,"A",0,"Pre-XDR","OM","hydrophilic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.765,-1.785,-1.416,2.25796,-1.236,-1.58,25,63,-0.129,5,5,8,0.050314465408805,"loop",-1.83333333333333,4.91,7.18700589334483e-05,2.42412778478352,0.0001249735077034,0,1.03410070803344e-29,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-1,0,-1,0,0,0,0,1,-0.452127659574468,-0.365891472868217,0.0822398181804938,-0.21074168797954,-0.413612565445026,0.263157894736842,-0.106260296540362,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","148/150","Q:E:H:K:V:N:P:A:G:S:D",-8.98740878149641,0.940032862253633,119.468044435491,-0.0752285585987755,NA,4692673.51081266,0.384555509373631,1,0,0,188.544222231268,0.999999999999997,"lineage2","other_mutations_pyrazinamide","ALA",0,"ERR2516749","ERR2516749","lineage2.2.1","gb","UK","pnca_p.pro54ala","A","-","PRO","PA54","pnca_complex.pdb"
|
|
"P54L","L4","PZA","P","P54",54,"L",1,"Pre-XDR","DM","hydrophilic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.765,-1.77,-0.0969999999999999,3.46567,-0.95,-0.4,33,66,-0.129,5,5,8,0.050314465408805,"loop",-1.83333333333333,4.91,0.0023717119448037,22.0580357142857,22.0580329576526,22.0491621136906,93.2270586345296,-16,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-10,0,-6,-4,-2,0,-2,-2,-0.448328267477204,-0.0250645994832041,0.126227245245085,-0.161977834612106,-0.104712041884817,0.347368421052632,-0.106260296540362,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","148/150","Q:E:H:K:V:N:P:A:G:S:D",3.09367684201887,7.52888191547387e-12,0.451813758844646,6.84723911447463,9.73717599077908,59.1593944160241,1.34356683555525,6.54726814958295e-16,15.1839398717709,8.90776823243485,65.3653818513773,4.6626285706706e-22,"lineage4","dr_mutations_pyrazinamide","LEU",0,"ERR1873531","ERR1873531","lineage4.1.1.3","za","South Africa","pnca_p.pro54leu","A","-","PRO","PA54","pnca_complex.pdb"
|
|
"P54L","L4","PZA","P","P54",54,"L",NA,"MDR","DM","hydrophilic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.765,-1.77,-0.0969999999999999,3.46567,-0.95,-0.4,33,66,-0.129,5,5,8,0.050314465408805,"loop",-1.83333333333333,4.91,0.0023717119448037,22.0580357142857,22.0580329576526,22.0491621136906,93.2270586345296,-16,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-10,0,-6,-4,-2,0,-2,-2,-0.448328267477204,-0.0250645994832041,0.126227245245085,-0.161977834612106,-0.104712041884817,0.347368421052632,-0.106260296540362,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","148/150","Q:E:H:K:V:N:P:A:G:S:D",3.09367684201887,7.52888191547387e-12,0.451813758844646,6.84723911447463,9.73717599077908,59.1593944160241,1.34356683555525,6.54726814958295e-16,15.1839398717709,8.90776823243485,65.3653818513773,4.6626285706706e-22,"lineage4","dr_mutations_pyrazinamide","LEU",0,"ERR2707182","ERR2707182","lineage4.3.2","cd","Democratic Republic of Congo","pnca_p.pro54leu","A","-","PRO","PA54","pnca_complex.pdb"
|
|
"P54L","L2","PZA","P","P54",54,"L",NA,"XDR","DM","hydrophilic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.765,-1.77,-0.0969999999999999,3.46567,-0.95,-0.4,33,66,-0.129,5,5,8,0.050314465408805,"loop",-1.83333333333333,4.91,0.0023717119448037,22.0580357142857,22.0580329576526,22.0491621136906,93.2270586345296,-16,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-10,0,-6,-4,-2,0,-2,-2,-0.448328267477204,-0.0250645994832041,0.126227245245085,-0.161977834612106,-0.104712041884817,0.347368421052632,-0.106260296540362,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","148/150","Q:E:H:K:V:N:P:A:G:S:D",3.09367684201887,7.52888191547387e-12,0.451813758844646,6.84723911447463,9.73717599077908,59.1593944160241,1.34356683555525,6.54726814958295e-16,15.1839398717709,8.90776823243485,65.3653818513773,4.6626285706706e-22,"lineage2","dr_mutations_pyrazinamide","LEU",0,"SRS797188","SRR1723707","lineage2.2.1.1","cn","China:Henan","pnca_p.pro54leu","A","-","PRO","PA54","pnca_complex.pdb"
|
|
"P54L","L2","PZA","P","P54",54,"L",0,"Pre-XDR","DM","hydrophilic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.765,-1.77,-0.0969999999999999,3.46567,-0.95,-0.4,33,66,-0.129,5,5,8,0.050314465408805,"loop",-1.83333333333333,4.91,0.0023717119448037,22.0580357142857,22.0580329576526,22.0491621136906,93.2270586345296,-16,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-10,0,-6,-4,-2,0,-2,-2,-0.448328267477204,-0.0250645994832041,0.126227245245085,-0.161977834612106,-0.104712041884817,0.347368421052632,-0.106260296540362,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","148/150","Q:E:H:K:V:N:P:A:G:S:D",3.09367684201887,7.52888191547387e-12,0.451813758844646,6.84723911447463,9.73717599077908,59.1593944160241,1.34356683555525,6.54726814958295e-16,15.1839398717709,8.90776823243485,65.3653818513773,4.6626285706706e-22,"lineage2","dr_mutations_pyrazinamide","LEU",0,"ERR553303","ERR553303","lineage2.2.1.1","mm","Burma","pnca_p.pro54leu","A","-","PRO","PA54","pnca_complex.pdb"
|
|
"P54L","L4","PZA","P","P54",54,"L",1,"Pre-XDR","DM","hydrophilic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.765,-1.77,-0.0969999999999999,3.46567,-0.95,-0.4,33,66,-0.129,5,5,8,0.050314465408805,"loop",-1.83333333333333,4.91,0.0023717119448037,22.0580357142857,22.0580329576526,22.0491621136906,93.2270586345296,-16,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-10,0,-6,-4,-2,0,-2,-2,-0.448328267477204,-0.0250645994832041,0.126227245245085,-0.161977834612106,-0.104712041884817,0.347368421052632,-0.106260296540362,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","148/150","Q:E:H:K:V:N:P:A:G:S:D",3.09367684201887,7.52888191547387e-12,0.451813758844646,6.84723911447463,9.73717599077908,59.1593944160241,1.34356683555525,6.54726814958295e-16,15.1839398717709,8.90776823243485,65.3653818513773,4.6626285706706e-22,"lineage4","dr_mutations_pyrazinamide","LEU",0,"ERR3335775","ERR3335775","lineage4.9","pk","Pakistan","pnca_p.pro54leu","A","-","PRO","PA54","pnca_complex.pdb"
|
|
"P54L","L2","PZA","P","P54",54,"L",NA,"MDR","DM","hydrophilic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.765,-1.77,-0.0969999999999999,3.46567,-0.95,-0.4,33,66,-0.129,5,5,8,0.050314465408805,"loop",-1.83333333333333,4.91,0.0023717119448037,22.0580357142857,22.0580329576526,22.0491621136906,93.2270586345296,-16,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-10,0,-6,-4,-2,0,-2,-2,-0.448328267477204,-0.0250645994832041,0.126227245245085,-0.161977834612106,-0.104712041884817,0.347368421052632,-0.106260296540362,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","148/150","Q:E:H:K:V:N:P:A:G:S:D",3.09367684201887,7.52888191547387e-12,0.451813758844646,6.84723911447463,9.73717599077908,59.1593944160241,1.34356683555525,6.54726814958295e-16,15.1839398717709,8.90776823243485,65.3653818513773,4.6626285706706e-22,"lineage2","dr_mutations_pyrazinamide","LEU",0,"SRR5074155","SRR5074155","lineage2.2.1","vn","Vietnam","pnca_p.pro54leu","A","-","PRO","PA54","pnca_complex.pdb"
|
|
"P54L","L3;L4","PZA","P","P54",54,"L",1,"MDR","DM","hydrophilic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.765,-1.77,-0.0969999999999999,3.46567,-0.95,-0.4,33,66,-0.129,5,5,8,0.050314465408805,"loop",-1.83333333333333,4.91,0.0023717119448037,22.0580357142857,22.0580329576526,22.0491621136906,93.2270586345296,-16,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-10,0,-6,-4,-2,0,-2,-2,-0.448328267477204,-0.0250645994832041,0.126227245245085,-0.161977834612106,-0.104712041884817,0.347368421052632,-0.106260296540362,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","148/150","Q:E:H:K:V:N:P:A:G:S:D",3.09367684201887,7.52888191547387e-12,0.451813758844646,6.84723911447463,9.73717599077908,59.1593944160241,1.34356683555525,6.54726814958295e-16,15.1839398717709,8.90776823243485,65.3653818513773,4.6626285706706e-22,"lineage3;lineage4","dr_mutations_pyrazinamide","LEU",0,"ERR2510340","ERR2510340","lineage4.9;lineage3","pk","Pakistan","pnca_p.pro54leu","A","-","PRO","PA54","pnca_complex.pdb"
|
|
"P54L","L4","PZA","P","P54",54,"L",1,"Pre-XDR","DM","hydrophilic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.765,-1.77,-0.0969999999999999,3.46567,-0.95,-0.4,33,66,-0.129,5,5,8,0.050314465408805,"loop",-1.83333333333333,4.91,0.0023717119448037,22.0580357142857,22.0580329576526,22.0491621136906,93.2270586345296,-16,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-10,0,-6,-4,-2,0,-2,-2,-0.448328267477204,-0.0250645994832041,0.126227245245085,-0.161977834612106,-0.104712041884817,0.347368421052632,-0.106260296540362,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","148/150","Q:E:H:K:V:N:P:A:G:S:D",3.09367684201887,7.52888191547387e-12,0.451813758844646,6.84723911447463,9.73717599077908,59.1593944160241,1.34356683555525,6.54726814958295e-16,15.1839398717709,8.90776823243485,65.3653818513773,4.6626285706706e-22,"lineage4","dr_mutations_pyrazinamide","LEU",0,"ERR2510588","ERR2510588","lineage4.9","pk","Pakistan","pnca_p.pro54leu","A","-","PRO","PA54","pnca_complex.pdb"
|
|
"P54L","L4","PZA","P","P54",54,"L",NA,"XDR","DM","hydrophilic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.765,-1.77,-0.0969999999999999,3.46567,-0.95,-0.4,33,66,-0.129,5,5,8,0.050314465408805,"loop",-1.83333333333333,4.91,0.0023717119448037,22.0580357142857,22.0580329576526,22.0491621136906,93.2270586345296,-16,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-10,0,-6,-4,-2,0,-2,-2,-0.448328267477204,-0.0250645994832041,0.126227245245085,-0.161977834612106,-0.104712041884817,0.347368421052632,-0.106260296540362,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","148/150","Q:E:H:K:V:N:P:A:G:S:D",3.09367684201887,7.52888191547387e-12,0.451813758844646,6.84723911447463,9.73717599077908,59.1593944160241,1.34356683555525,6.54726814958295e-16,15.1839398717709,8.90776823243485,65.3653818513773,4.6626285706706e-22,"lineage4","dr_mutations_pyrazinamide","LEU",0,"ERR688030","ERR688030","lineage4.9","pk","Pakistan","pnca_p.pro54leu","A","-","PRO","PA54","pnca_complex.pdb"
|
|
"P54L","L2","PZA","P","P54",54,"L",0,"Pre-XDR","DM","hydrophilic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.765,-1.77,-0.0969999999999999,3.46567,-0.95,-0.4,33,66,-0.129,5,5,8,0.050314465408805,"loop",-1.83333333333333,4.91,0.0023717119448037,22.0580357142857,22.0580329576526,22.0491621136906,93.2270586345296,-16,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-10,0,-6,-4,-2,0,-2,-2,-0.448328267477204,-0.0250645994832041,0.126227245245085,-0.161977834612106,-0.104712041884817,0.347368421052632,-0.106260296540362,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","148/150","Q:E:H:K:V:N:P:A:G:S:D",3.09367684201887,7.52888191547387e-12,0.451813758844646,6.84723911447463,9.73717599077908,59.1593944160241,1.34356683555525,6.54726814958295e-16,15.1839398717709,8.90776823243485,65.3653818513773,4.6626285706706e-22,"lineage2","dr_mutations_pyrazinamide","LEU",0,"ERR108428,1071Q-sc-2011-10-12T14:58:19Z-1289093","ERR108428","lineage2.2.1","ru","Russia,Samara","pnca_p.pro54leu","A","-","PRO","PA54","pnca_complex.pdb"
|
|
"P54L","L4","PZA","P","P54",54,"L",0,"XDR","DM","hydrophilic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.765,-1.77,-0.0969999999999999,3.46567,-0.95,-0.4,33,66,-0.129,5,5,8,0.050314465408805,"loop",-1.83333333333333,4.91,0.0023717119448037,22.0580357142857,22.0580329576526,22.0491621136906,93.2270586345296,-16,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-10,0,-6,-4,-2,0,-2,-2,-0.448328267477204,-0.0250645994832041,0.126227245245085,-0.161977834612106,-0.104712041884817,0.347368421052632,-0.106260296540362,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","148/150","Q:E:H:K:V:N:P:A:G:S:D",3.09367684201887,7.52888191547387e-12,0.451813758844646,6.84723911447463,9.73717599077908,59.1593944160241,1.34356683555525,6.54726814958295e-16,15.1839398717709,8.90776823243485,65.3653818513773,4.6626285706706e-22,"lineage4","dr_mutations_pyrazinamide","LEU",0,"ERR2510315","ERR2510315","lineage4.9","pk","Pakistan","pnca_p.pro54leu","A","-","PRO","PA54","pnca_complex.pdb"
|
|
"P54L","L4","PZA","P","P54",54,"L",NA,"MDR","DM","hydrophilic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.765,-1.77,-0.0969999999999999,3.46567,-0.95,-0.4,33,66,-0.129,5,5,8,0.050314465408805,"loop",-1.83333333333333,4.91,0.0023717119448037,22.0580357142857,22.0580329576526,22.0491621136906,93.2270586345296,-16,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-10,0,-6,-4,-2,0,-2,-2,-0.448328267477204,-0.0250645994832041,0.126227245245085,-0.161977834612106,-0.104712041884817,0.347368421052632,-0.106260296540362,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","148/150","Q:E:H:K:V:N:P:A:G:S:D",3.09367684201887,7.52888191547387e-12,0.451813758844646,6.84723911447463,9.73717599077908,59.1593944160241,1.34356683555525,6.54726814958295e-16,15.1839398717709,8.90776823243485,65.3653818513773,4.6626285706706e-22,"lineage4","dr_mutations_pyrazinamide","LEU",0,"ERR2706997","ERR2706997","lineage4.3.2","cd","Democratic Republic of Congo","pnca_p.pro54leu","A","-","PRO","PA54","pnca_complex.pdb"
|
|
"P54L","L2","PZA","P","P54",54,"L",1,"XDR","DM","hydrophilic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.765,-1.77,-0.0969999999999999,3.46567,-0.95,-0.4,33,66,-0.129,5,5,8,0.050314465408805,"loop",-1.83333333333333,4.91,0.0023717119448037,22.0580357142857,22.0580329576526,22.0491621136906,93.2270586345296,-16,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-10,0,-6,-4,-2,0,-2,-2,-0.448328267477204,-0.0250645994832041,0.126227245245085,-0.161977834612106,-0.104712041884817,0.347368421052632,-0.106260296540362,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","148/150","Q:E:H:K:V:N:P:A:G:S:D",3.09367684201887,7.52888191547387e-12,0.451813758844646,6.84723911447463,9.73717599077908,59.1593944160241,1.34356683555525,6.54726814958295e-16,15.1839398717709,8.90776823243485,65.3653818513773,4.6626285706706e-22,"lineage2","dr_mutations_pyrazinamide","LEU",0,"MDR_16412","SRR6824696","lineage2.2.1.1","cn","China: Fugou County, Zhoukou City, Henan Province","pnca_p.pro54leu","A","-","PRO","PA54","pnca_complex.pdb"
|
|
"P54L","L4","PZA","P","P54",54,"L",1,"XDR","DM","hydrophilic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.765,-1.77,-0.0969999999999999,3.46567,-0.95,-0.4,33,66,-0.129,5,5,8,0.050314465408805,"loop",-1.83333333333333,4.91,0.0023717119448037,22.0580357142857,22.0580329576526,22.0491621136906,93.2270586345296,-16,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-10,0,-6,-4,-2,0,-2,-2,-0.448328267477204,-0.0250645994832041,0.126227245245085,-0.161977834612106,-0.104712041884817,0.347368421052632,-0.106260296540362,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","148/150","Q:E:H:K:V:N:P:A:G:S:D",3.09367684201887,7.52888191547387e-12,0.451813758844646,6.84723911447463,9.73717599077908,59.1593944160241,1.34356683555525,6.54726814958295e-16,15.1839398717709,8.90776823243485,65.3653818513773,4.6626285706706e-22,"lineage4","dr_mutations_pyrazinamide","LEU",0,"ERR2510392","ERR2510392","lineage4.9","pk","Pakistan","pnca_p.pro54leu","A","-","PRO","PA54","pnca_complex.pdb"
|
|
"P54L","L4","PZA","P","P54",54,"L",1,"MDR","DM","hydrophilic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.765,-1.77,-0.0969999999999999,3.46567,-0.95,-0.4,33,66,-0.129,5,5,8,0.050314465408805,"loop",-1.83333333333333,4.91,0.0023717119448037,22.0580357142857,22.0580329576526,22.0491621136906,93.2270586345296,-16,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-10,0,-6,-4,-2,0,-2,-2,-0.448328267477204,-0.0250645994832041,0.126227245245085,-0.161977834612106,-0.104712041884817,0.347368421052632,-0.106260296540362,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","148/150","Q:E:H:K:V:N:P:A:G:S:D",3.09367684201887,7.52888191547387e-12,0.451813758844646,6.84723911447463,9.73717599077908,59.1593944160241,1.34356683555525,6.54726814958295e-16,15.1839398717709,8.90776823243485,65.3653818513773,4.6626285706706e-22,"lineage4","dr_mutations_pyrazinamide","LEU",0,"ERR2510482","ERR2510482","lineage4.9","pk","Pakistan","pnca_p.pro54leu","A","-","PRO","PA54","pnca_complex.pdb"
|
|
"P54L","L4","PZA","P","P54",54,"L",NA,"MDR","DM","hydrophilic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.765,-1.77,-0.0969999999999999,3.46567,-0.95,-0.4,33,66,-0.129,5,5,8,0.050314465408805,"loop",-1.83333333333333,4.91,0.0023717119448037,22.0580357142857,22.0580329576526,22.0491621136906,93.2270586345296,-16,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-10,0,-6,-4,-2,0,-2,-2,-0.448328267477204,-0.0250645994832041,0.126227245245085,-0.161977834612106,-0.104712041884817,0.347368421052632,-0.106260296540362,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","148/150","Q:E:H:K:V:N:P:A:G:S:D",3.09367684201887,7.52888191547387e-12,0.451813758844646,6.84723911447463,9.73717599077908,59.1593944160241,1.34356683555525,6.54726814958295e-16,15.1839398717709,8.90776823243485,65.3653818513773,4.6626285706706e-22,"lineage4","dr_mutations_pyrazinamide","LEU",0,"SAMN02231179","SRR1049972_SRR998812_SRR998809_SRR998810_SRR998811","lineage4.1","ml","Mali","pnca_p.pro54leu","A","-","PRO","PA54","pnca_complex.pdb"
|
|
"P54L","L4","PZA","P","P54",54,"L",1,"Pre-XDR","DM","hydrophilic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.765,-1.77,-0.0969999999999999,3.46567,-0.95,-0.4,33,66,-0.129,5,5,8,0.050314465408805,"loop",-1.83333333333333,4.91,0.0023717119448037,22.0580357142857,22.0580329576526,22.0491621136906,93.2270586345296,-16,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-10,0,-6,-4,-2,0,-2,-2,-0.448328267477204,-0.0250645994832041,0.126227245245085,-0.161977834612106,-0.104712041884817,0.347368421052632,-0.106260296540362,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","148/150","Q:E:H:K:V:N:P:A:G:S:D",3.09367684201887,7.52888191547387e-12,0.451813758844646,6.84723911447463,9.73717599077908,59.1593944160241,1.34356683555525,6.54726814958295e-16,15.1839398717709,8.90776823243485,65.3653818513773,4.6626285706706e-22,"lineage4","dr_mutations_pyrazinamide","LEU",0,"ERR2510873","ERR2510873","lineage4.9","pk","Pakistan","pnca_p.pro54leu","A","-","PRO","PA54","pnca_complex.pdb"
|
|
"P54L","L1","PZA","P","P54",54,"L",NA,"MDR","DM","hydrophilic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.765,-1.77,-0.0969999999999999,3.46567,-0.95,-0.4,33,66,-0.129,5,5,8,0.050314465408805,"loop",-1.83333333333333,4.91,0.0023717119448037,22.0580357142857,22.0580329576526,22.0491621136906,93.2270586345296,-16,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-10,0,-6,-4,-2,0,-2,-2,-0.448328267477204,-0.0250645994832041,0.126227245245085,-0.161977834612106,-0.104712041884817,0.347368421052632,-0.106260296540362,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","148/150","Q:E:H:K:V:N:P:A:G:S:D",3.09367684201887,7.52888191547387e-12,0.451813758844646,6.84723911447463,9.73717599077908,59.1593944160241,1.34356683555525,6.54726814958295e-16,15.1839398717709,8.90776823243485,65.3653818513773,4.6626285706706e-22,"lineage1","dr_mutations_pyrazinamide","LEU",0,"SAMN07236475,SRR5709789","SRR5709789","lineage1.1.1","th","Thailand","pnca_p.pro54leu","A","-","PRO","PA54","pnca_complex.pdb"
|
|
"P54L","L4","PZA","P","P54",54,"L",1,"Pre-XDR","DM","hydrophilic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.765,-1.77,-0.0969999999999999,3.46567,-0.95,-0.4,33,66,-0.129,5,5,8,0.050314465408805,"loop",-1.83333333333333,4.91,0.0023717119448037,22.0580357142857,22.0580329576526,22.0491621136906,93.2270586345296,-16,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-10,0,-6,-4,-2,0,-2,-2,-0.448328267477204,-0.0250645994832041,0.126227245245085,-0.161977834612106,-0.104712041884817,0.347368421052632,-0.106260296540362,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","148/150","Q:E:H:K:V:N:P:A:G:S:D",3.09367684201887,7.52888191547387e-12,0.451813758844646,6.84723911447463,9.73717599077908,59.1593944160241,1.34356683555525,6.54726814958295e-16,15.1839398717709,8.90776823243485,65.3653818513773,4.6626285706706e-22,"lineage4","dr_mutations_pyrazinamide","LEU",0,"ERR2516508","ERR2516508","lineage4.3.4.2","pe","Peru","pnca_p.pro54leu","A","-","PRO","PA54","pnca_complex.pdb"
|
|
"P54L","L2","PZA","P","P54",54,"L",NA,"XDR","DM","hydrophilic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.765,-1.77,-0.0969999999999999,3.46567,-0.95,-0.4,33,66,-0.129,5,5,8,0.050314465408805,"loop",-1.83333333333333,4.91,0.0023717119448037,22.0580357142857,22.0580329576526,22.0491621136906,93.2270586345296,-16,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-10,0,-6,-4,-2,0,-2,-2,-0.448328267477204,-0.0250645994832041,0.126227245245085,-0.161977834612106,-0.104712041884817,0.347368421052632,-0.106260296540362,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","148/150","Q:E:H:K:V:N:P:A:G:S:D",3.09367684201887,7.52888191547387e-12,0.451813758844646,6.84723911447463,9.73717599077908,59.1593944160241,1.34356683555525,6.54726814958295e-16,15.1839398717709,8.90776823243485,65.3653818513773,4.6626285706706e-22,"lineage2","dr_mutations_pyrazinamide","LEU",0,"SRS797189","SRR1723706","lineage2.2.1.1","cn","China:Henan","pnca_p.pro54leu","A","-","PRO","PA54","pnca_complex.pdb"
|
|
"P54L","L4","PZA","P","P54",54,"L",1,"MDR","DM","hydrophilic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.765,-1.77,-0.0969999999999999,3.46567,-0.95,-0.4,33,66,-0.129,5,5,8,0.050314465408805,"loop",-1.83333333333333,4.91,0.0023717119448037,22.0580357142857,22.0580329576526,22.0491621136906,93.2270586345296,-16,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-10,0,-6,-4,-2,0,-2,-2,-0.448328267477204,-0.0250645994832041,0.126227245245085,-0.161977834612106,-0.104712041884817,0.347368421052632,-0.106260296540362,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","148/150","Q:E:H:K:V:N:P:A:G:S:D",3.09367684201887,7.52888191547387e-12,0.451813758844646,6.84723911447463,9.73717599077908,59.1593944160241,1.34356683555525,6.54726814958295e-16,15.1839398717709,8.90776823243485,65.3653818513773,4.6626285706706e-22,"lineage4","dr_mutations_pyrazinamide","LEU",0,"ERR2510301","ERR2510301","lineage4.9","pk","Pakistan","pnca_p.pro54leu","A","-","PRO","PA54","pnca_complex.pdb"
|
|
"P54L","L2","PZA","P","P54",54,"L",1,"Pre-XDR","DM","hydrophilic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.765,-1.77,-0.0969999999999999,3.46567,-0.95,-0.4,33,66,-0.129,5,5,8,0.050314465408805,"loop",-1.83333333333333,4.91,0.0023717119448037,22.0580357142857,22.0580329576526,22.0491621136906,93.2270586345296,-16,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-10,0,-6,-4,-2,0,-2,-2,-0.448328267477204,-0.0250645994832041,0.126227245245085,-0.161977834612106,-0.104712041884817,0.347368421052632,-0.106260296540362,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","148/150","Q:E:H:K:V:N:P:A:G:S:D",3.09367684201887,7.52888191547387e-12,0.451813758844646,6.84723911447463,9.73717599077908,59.1593944160241,1.34356683555525,6.54726814958295e-16,15.1839398717709,8.90776823243485,65.3653818513773,4.6626285706706e-22,"lineage2","dr_mutations_pyrazinamide","LEU",0,"ERS457337,SAMEA2533935","ERR551428_ERR551429","lineage2.2.1","uz","Nukus","pnca_p.pro54leu","A","-","PRO","PA54","pnca_complex.pdb"
|
|
"P54L","L2","PZA","P","P54",54,"L",0,"Pre-XDR","DM","hydrophilic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.765,-1.77,-0.0969999999999999,3.46567,-0.95,-0.4,33,66,-0.129,5,5,8,0.050314465408805,"loop",-1.83333333333333,4.91,0.0023717119448037,22.0580357142857,22.0580329576526,22.0491621136906,93.2270586345296,-16,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-10,0,-6,-4,-2,0,-2,-2,-0.448328267477204,-0.0250645994832041,0.126227245245085,-0.161977834612106,-0.104712041884817,0.347368421052632,-0.106260296540362,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","148/150","Q:E:H:K:V:N:P:A:G:S:D",3.09367684201887,7.52888191547387e-12,0.451813758844646,6.84723911447463,9.73717599077908,59.1593944160241,1.34356683555525,6.54726814958295e-16,15.1839398717709,8.90776823243485,65.3653818513773,4.6626285706706e-22,"lineage2","dr_mutations_pyrazinamide","LEU",0,"SAMEA2534211,ERS457613","ERR551815_ERR551816","lineage2.2.1","uz","Nukus","pnca_p.pro54leu","A","-","PRO","PA54","pnca_complex.pdb"
|
|
"P54L","L1","PZA","P","P54",54,"L",NA,"MDR","DM","hydrophilic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.765,-1.77,-0.0969999999999999,3.46567,-0.95,-0.4,33,66,-0.129,5,5,8,0.050314465408805,"loop",-1.83333333333333,4.91,0.0023717119448037,22.0580357142857,22.0580329576526,22.0491621136906,93.2270586345296,-16,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-10,0,-6,-4,-2,0,-2,-2,-0.448328267477204,-0.0250645994832041,0.126227245245085,-0.161977834612106,-0.104712041884817,0.347368421052632,-0.106260296540362,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","148/150","Q:E:H:K:V:N:P:A:G:S:D",3.09367684201887,7.52888191547387e-12,0.451813758844646,6.84723911447463,9.73717599077908,59.1593944160241,1.34356683555525,6.54726814958295e-16,15.1839398717709,8.90776823243485,65.3653818513773,4.6626285706706e-22,"lineage1","dr_mutations_pyrazinamide","LEU",0,"ERR3256112","ERR3256112","lineage1.2.1","ph","Philippines","pnca_p.pro54leu","A","-","PRO","PA54","pnca_complex.pdb"
|
|
"P54L","L4","PZA","P","P54",54,"L",1,"Pre-XDR","DM","hydrophilic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.765,-1.77,-0.0969999999999999,3.46567,-0.95,-0.4,33,66,-0.129,5,5,8,0.050314465408805,"loop",-1.83333333333333,4.91,0.0023717119448037,22.0580357142857,22.0580329576526,22.0491621136906,93.2270586345296,-16,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-10,0,-6,-4,-2,0,-2,-2,-0.448328267477204,-0.0250645994832041,0.126227245245085,-0.161977834612106,-0.104712041884817,0.347368421052632,-0.106260296540362,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","148/150","Q:E:H:K:V:N:P:A:G:S:D",3.09367684201887,7.52888191547387e-12,0.451813758844646,6.84723911447463,9.73717599077908,59.1593944160241,1.34356683555525,6.54726814958295e-16,15.1839398717709,8.90776823243485,65.3653818513773,4.6626285706706e-22,"lineage4","dr_mutations_pyrazinamide","LEU",0,"ERR2510427","ERR2510427","lineage4.9","pk","Pakistan","pnca_p.pro54leu","A","-","PRO","PA54","pnca_complex.pdb"
|
|
"P54L","L4","PZA","P","P54",54,"L",1,"Pre-XDR","DM","hydrophilic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.765,-1.77,-0.0969999999999999,3.46567,-0.95,-0.4,33,66,-0.129,5,5,8,0.050314465408805,"loop",-1.83333333333333,4.91,0.0023717119448037,22.0580357142857,22.0580329576526,22.0491621136906,93.2270586345296,-16,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-10,0,-6,-4,-2,0,-2,-2,-0.448328267477204,-0.0250645994832041,0.126227245245085,-0.161977834612106,-0.104712041884817,0.347368421052632,-0.106260296540362,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","148/150","Q:E:H:K:V:N:P:A:G:S:D",3.09367684201887,7.52888191547387e-12,0.451813758844646,6.84723911447463,9.73717599077908,59.1593944160241,1.34356683555525,6.54726814958295e-16,15.1839398717709,8.90776823243485,65.3653818513773,4.6626285706706e-22,"lineage4","dr_mutations_pyrazinamide","LEU",0,"ERR2510580","ERR2510580","lineage4.9","pk","Pakistan","pnca_p.pro54leu","A","-","PRO","PA54","pnca_complex.pdb"
|
|
"P54L","L3","PZA","P","P54",54,"L",1,"Pre-MDR","DM","hydrophilic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.765,-1.77,-0.0969999999999999,3.46567,-0.95,-0.4,33,66,-0.129,5,5,8,0.050314465408805,"loop",-1.83333333333333,4.91,0.0023717119448037,22.0580357142857,22.0580329576526,22.0491621136906,93.2270586345296,-16,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-10,0,-6,-4,-2,0,-2,-2,-0.448328267477204,-0.0250645994832041,0.126227245245085,-0.161977834612106,-0.104712041884817,0.347368421052632,-0.106260296540362,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","148/150","Q:E:H:K:V:N:P:A:G:S:D",3.09367684201887,7.52888191547387e-12,0.451813758844646,6.84723911447463,9.73717599077908,59.1593944160241,1.34356683555525,6.54726814958295e-16,15.1839398717709,8.90776823243485,65.3653818513773,4.6626285706706e-22,"lineage3","dr_mutations_pyrazinamide","LEU",0,"ERR2510623","ERR2510623","lineage3.1","pk","Pakistan","pnca_p.pro54leu","A","-","PRO","PA54","pnca_complex.pdb"
|
|
"P54L","L4","PZA","P","P54",54,"L",1,"MDR","DM","hydrophilic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.765,-1.77,-0.0969999999999999,3.46567,-0.95,-0.4,33,66,-0.129,5,5,8,0.050314465408805,"loop",-1.83333333333333,4.91,0.0023717119448037,22.0580357142857,22.0580329576526,22.0491621136906,93.2270586345296,-16,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-10,0,-6,-4,-2,0,-2,-2,-0.448328267477204,-0.0250645994832041,0.126227245245085,-0.161977834612106,-0.104712041884817,0.347368421052632,-0.106260296540362,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","148/150","Q:E:H:K:V:N:P:A:G:S:D",3.09367684201887,7.52888191547387e-12,0.451813758844646,6.84723911447463,9.73717599077908,59.1593944160241,1.34356683555525,6.54726814958295e-16,15.1839398717709,8.90776823243485,65.3653818513773,4.6626285706706e-22,"lineage4","dr_mutations_pyrazinamide","LEU",0,"ERR2510440","ERR2510440","lineage4.9","pk","Pakistan","pnca_p.pro54leu","A","-","PRO","PA54","pnca_complex.pdb"
|
|
"P54L","L4","PZA","P","P54",54,"L",1,"Pre-XDR","DM","hydrophilic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.765,-1.77,-0.0969999999999999,3.46567,-0.95,-0.4,33,66,-0.129,5,5,8,0.050314465408805,"loop",-1.83333333333333,4.91,0.0023717119448037,22.0580357142857,22.0580329576526,22.0491621136906,93.2270586345296,-16,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-10,0,-6,-4,-2,0,-2,-2,-0.448328267477204,-0.0250645994832041,0.126227245245085,-0.161977834612106,-0.104712041884817,0.347368421052632,-0.106260296540362,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","148/150","Q:E:H:K:V:N:P:A:G:S:D",3.09367684201887,7.52888191547387e-12,0.451813758844646,6.84723911447463,9.73717599077908,59.1593944160241,1.34356683555525,6.54726814958295e-16,15.1839398717709,8.90776823243485,65.3653818513773,4.6626285706706e-22,"lineage4","dr_mutations_pyrazinamide","LEU",0,"ERR2510434","ERR2510434","lineage4.9","pk","Pakistan","pnca_p.pro54leu","A","-","PRO","PA54","pnca_complex.pdb"
|
|
"P54L","L4","PZA","P","P54",54,"L",1,"Pre-XDR","DM","hydrophilic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.765,-1.77,-0.0969999999999999,3.46567,-0.95,-0.4,33,66,-0.129,5,5,8,0.050314465408805,"loop",-1.83333333333333,4.91,0.0023717119448037,22.0580357142857,22.0580329576526,22.0491621136906,93.2270586345296,-16,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-10,0,-6,-4,-2,0,-2,-2,-0.448328267477204,-0.0250645994832041,0.126227245245085,-0.161977834612106,-0.104712041884817,0.347368421052632,-0.106260296540362,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","148/150","Q:E:H:K:V:N:P:A:G:S:D",3.09367684201887,7.52888191547387e-12,0.451813758844646,6.84723911447463,9.73717599077908,59.1593944160241,1.34356683555525,6.54726814958295e-16,15.1839398717709,8.90776823243485,65.3653818513773,4.6626285706706e-22,"lineage4","dr_mutations_pyrazinamide","LEU",0,"ERR2510879","ERR2510879","lineage4.9","pk","Pakistan","pnca_p.pro54leu","A","-","PRO","PA54","pnca_complex.pdb"
|
|
"P54L","L3","PZA","P","P54",54,"L",0,"MDR","DM","hydrophilic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.765,-1.77,-0.0969999999999999,3.46567,-0.95,-0.4,33,66,-0.129,5,5,8,0.050314465408805,"loop",-1.83333333333333,4.91,0.0023717119448037,22.0580357142857,22.0580329576526,22.0491621136906,93.2270586345296,-16,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-10,0,-6,-4,-2,0,-2,-2,-0.448328267477204,-0.0250645994832041,0.126227245245085,-0.161977834612106,-0.104712041884817,0.347368421052632,-0.106260296540362,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","148/150","Q:E:H:K:V:N:P:A:G:S:D",3.09367684201887,7.52888191547387e-12,0.451813758844646,6.84723911447463,9.73717599077908,59.1593944160241,1.34356683555525,6.54726814958295e-16,15.1839398717709,8.90776823243485,65.3653818513773,4.6626285706706e-22,"lineage3","dr_mutations_pyrazinamide","LEU",0,"ERR2510474","ERR2510474","lineage3","pk","Pakistan","pnca_p.pro54leu","A","-","PRO","PA54","pnca_complex.pdb"
|
|
"P54L","L2","PZA","P","P54",54,"L",NA,"MDR","DM","hydrophilic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.765,-1.77,-0.0969999999999999,3.46567,-0.95,-0.4,33,66,-0.129,5,5,8,0.050314465408805,"loop",-1.83333333333333,4.91,0.0023717119448037,22.0580357142857,22.0580329576526,22.0491621136906,93.2270586345296,-16,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-10,0,-6,-4,-2,0,-2,-2,-0.448328267477204,-0.0250645994832041,0.126227245245085,-0.161977834612106,-0.104712041884817,0.347368421052632,-0.106260296540362,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","148/150","Q:E:H:K:V:N:P:A:G:S:D",3.09367684201887,7.52888191547387e-12,0.451813758844646,6.84723911447463,9.73717599077908,59.1593944160241,1.34356683555525,6.54726814958295e-16,15.1839398717709,8.90776823243485,65.3653818513773,4.6626285706706e-22,"lineage2","dr_mutations_pyrazinamide","LEU",0,"SRR6398091","SRR6398091","lineage2.2.1","ca","Canada","pnca_p.pro54leu","A","-","PRO","PA54","pnca_complex.pdb"
|
|
"P54L","L4","PZA","P","P54",54,"L",1,"Pre-XDR","DM","hydrophilic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.765,-1.77,-0.0969999999999999,3.46567,-0.95,-0.4,33,66,-0.129,5,5,8,0.050314465408805,"loop",-1.83333333333333,4.91,0.0023717119448037,22.0580357142857,22.0580329576526,22.0491621136906,93.2270586345296,-16,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-10,0,-6,-4,-2,0,-2,-2,-0.448328267477204,-0.0250645994832041,0.126227245245085,-0.161977834612106,-0.104712041884817,0.347368421052632,-0.106260296540362,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","148/150","Q:E:H:K:V:N:P:A:G:S:D",3.09367684201887,7.52888191547387e-12,0.451813758844646,6.84723911447463,9.73717599077908,59.1593944160241,1.34356683555525,6.54726814958295e-16,15.1839398717709,8.90776823243485,65.3653818513773,4.6626285706706e-22,"lineage4","dr_mutations_pyrazinamide","LEU",0,"ERR2510398","ERR2510398","lineage4.9","pk","Pakistan","pnca_p.pro54leu","A","-","PRO","PA54","pnca_complex.pdb"
|
|
"P54L","L2","PZA","P","P54",54,"L",1,"Pre-XDR","DM","hydrophilic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.765,-1.77,-0.0969999999999999,3.46567,-0.95,-0.4,33,66,-0.129,5,5,8,0.050314465408805,"loop",-1.83333333333333,4.91,0.0023717119448037,22.0580357142857,22.0580329576526,22.0491621136906,93.2270586345296,-16,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-10,0,-6,-4,-2,0,-2,-2,-0.448328267477204,-0.0250645994832041,0.126227245245085,-0.161977834612106,-0.104712041884817,0.347368421052632,-0.106260296540362,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","148/150","Q:E:H:K:V:N:P:A:G:S:D",3.09367684201887,7.52888191547387e-12,0.451813758844646,6.84723911447463,9.73717599077908,59.1593944160241,1.34356683555525,6.54726814958295e-16,15.1839398717709,8.90776823243485,65.3653818513773,4.6626285706706e-22,"lineage2","dr_mutations_pyrazinamide","LEU",0,"ERS456956","ERR550908_ERR550906_ERR550907","lineage2.2.1","uz","Nukus","pnca_p.pro54leu","A","-","PRO","PA54","pnca_complex.pdb"
|
|
"P54L","L2","PZA","P","P54",54,"L",0,"Pre-XDR","DM","hydrophilic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.765,-1.77,-0.0969999999999999,3.46567,-0.95,-0.4,33,66,-0.129,5,5,8,0.050314465408805,"loop",-1.83333333333333,4.91,0.0023717119448037,22.0580357142857,22.0580329576526,22.0491621136906,93.2270586345296,-16,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-10,0,-6,-4,-2,0,-2,-2,-0.448328267477204,-0.0250645994832041,0.126227245245085,-0.161977834612106,-0.104712041884817,0.347368421052632,-0.106260296540362,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","148/150","Q:E:H:K:V:N:P:A:G:S:D",3.09367684201887,7.52888191547387e-12,0.451813758844646,6.84723911447463,9.73717599077908,59.1593944160241,1.34356683555525,6.54726814958295e-16,15.1839398717709,8.90776823243485,65.3653818513773,4.6626285706706e-22,"lineage2","dr_mutations_pyrazinamide","LEU",0,"ERS456915","ERR550842_ERR550841","lineage2.2.1","uz","Nukus","pnca_p.pro54leu","A","-","PRO","PA54","pnca_complex.pdb"
|
|
"P54L","L4","PZA","P","P54",54,"L",1,"Pre-XDR","DM","hydrophilic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.765,-1.77,-0.0969999999999999,3.46567,-0.95,-0.4,33,66,-0.129,5,5,8,0.050314465408805,"loop",-1.83333333333333,4.91,0.0023717119448037,22.0580357142857,22.0580329576526,22.0491621136906,93.2270586345296,-16,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-10,0,-6,-4,-2,0,-2,-2,-0.448328267477204,-0.0250645994832041,0.126227245245085,-0.161977834612106,-0.104712041884817,0.347368421052632,-0.106260296540362,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","148/150","Q:E:H:K:V:N:P:A:G:S:D",3.09367684201887,7.52888191547387e-12,0.451813758844646,6.84723911447463,9.73717599077908,59.1593944160241,1.34356683555525,6.54726814958295e-16,15.1839398717709,8.90776823243485,65.3653818513773,4.6626285706706e-22,"lineage4","dr_mutations_pyrazinamide","LEU",0,"ERR2510558","ERR2510558","lineage4.9","pk","Pakistan","pnca_p.pro54leu","A","-","PRO","PA54","pnca_complex.pdb"
|
|
"P54L","L4","PZA","P","P54",54,"L",1,"Pre-XDR","DM","hydrophilic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.765,-1.77,-0.0969999999999999,3.46567,-0.95,-0.4,33,66,-0.129,5,5,8,0.050314465408805,"loop",-1.83333333333333,4.91,0.0023717119448037,22.0580357142857,22.0580329576526,22.0491621136906,93.2270586345296,-16,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-10,0,-6,-4,-2,0,-2,-2,-0.448328267477204,-0.0250645994832041,0.126227245245085,-0.161977834612106,-0.104712041884817,0.347368421052632,-0.106260296540362,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","148/150","Q:E:H:K:V:N:P:A:G:S:D",3.09367684201887,7.52888191547387e-12,0.451813758844646,6.84723911447463,9.73717599077908,59.1593944160241,1.34356683555525,6.54726814958295e-16,15.1839398717709,8.90776823243485,65.3653818513773,4.6626285706706e-22,"lineage4","dr_mutations_pyrazinamide","LEU",0,"ERR2510411","ERR2510411","lineage4.9","pk","Pakistan","pnca_p.pro54leu","A","-","PRO","PA54","pnca_complex.pdb"
|
|
"P54L","L4","PZA","P","P54",54,"L",1,"Pre-XDR","DM","hydrophilic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.765,-1.77,-0.0969999999999999,3.46567,-0.95,-0.4,33,66,-0.129,5,5,8,0.050314465408805,"loop",-1.83333333333333,4.91,0.0023717119448037,22.0580357142857,22.0580329576526,22.0491621136906,93.2270586345296,-16,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-10,0,-6,-4,-2,0,-2,-2,-0.448328267477204,-0.0250645994832041,0.126227245245085,-0.161977834612106,-0.104712041884817,0.347368421052632,-0.106260296540362,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","148/150","Q:E:H:K:V:N:P:A:G:S:D",3.09367684201887,7.52888191547387e-12,0.451813758844646,6.84723911447463,9.73717599077908,59.1593944160241,1.34356683555525,6.54726814958295e-16,15.1839398717709,8.90776823243485,65.3653818513773,4.6626285706706e-22,"lineage4","dr_mutations_pyrazinamide","LEU",0,"ERR2510299","ERR2510299","lineage4.9","pk","Pakistan","pnca_p.pro54leu","A","-","PRO","PA54","pnca_complex.pdb"
|
|
"P54L","L4","PZA","P","P54",54,"L",NA,"MDR","DM","hydrophilic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.765,-1.77,-0.0969999999999999,3.46567,-0.95,-0.4,33,66,-0.129,5,5,8,0.050314465408805,"loop",-1.83333333333333,4.91,0.0023717119448037,22.0580357142857,22.0580329576526,22.0491621136906,93.2270586345296,-16,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-10,0,-6,-4,-2,0,-2,-2,-0.448328267477204,-0.0250645994832041,0.126227245245085,-0.161977834612106,-0.104712041884817,0.347368421052632,-0.106260296540362,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","148/150","Q:E:H:K:V:N:P:A:G:S:D",3.09367684201887,7.52888191547387e-12,0.451813758844646,6.84723911447463,9.73717599077908,59.1593944160241,1.34356683555525,6.54726814958295e-16,15.1839398717709,8.90776823243485,65.3653818513773,4.6626285706706e-22,"lineage4","dr_mutations_pyrazinamide","LEU",0,"ERR2706979","ERR2706979","lineage4.3.2","cd","Democratic Republic of Congo","pnca_p.pro54leu","A","-","PRO","PA54","pnca_complex.pdb"
|
|
"P54L","L4","PZA","P","P54",54,"L",1,"MDR","DM","hydrophilic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.765,-1.77,-0.0969999999999999,3.46567,-0.95,-0.4,33,66,-0.129,5,5,8,0.050314465408805,"loop",-1.83333333333333,4.91,0.0023717119448037,22.0580357142857,22.0580329576526,22.0491621136906,93.2270586345296,-16,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-10,0,-6,-4,-2,0,-2,-2,-0.448328267477204,-0.0250645994832041,0.126227245245085,-0.161977834612106,-0.104712041884817,0.347368421052632,-0.106260296540362,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","148/150","Q:E:H:K:V:N:P:A:G:S:D",3.09367684201887,7.52888191547387e-12,0.451813758844646,6.84723911447463,9.73717599077908,59.1593944160241,1.34356683555525,6.54726814958295e-16,15.1839398717709,8.90776823243485,65.3653818513773,4.6626285706706e-22,"lineage4","dr_mutations_pyrazinamide","LEU",0,"ERR2510641","ERR2510641","lineage4.9","pk","Pakistan","pnca_p.pro54leu","A","-","PRO","PA54","pnca_complex.pdb"
|
|
"P54L","L4","PZA","P","P54",54,"L",1,"Pre-XDR","DM","hydrophilic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.765,-1.77,-0.0969999999999999,3.46567,-0.95,-0.4,33,66,-0.129,5,5,8,0.050314465408805,"loop",-1.83333333333333,4.91,0.0023717119448037,22.0580357142857,22.0580329576526,22.0491621136906,93.2270586345296,-16,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-10,0,-6,-4,-2,0,-2,-2,-0.448328267477204,-0.0250645994832041,0.126227245245085,-0.161977834612106,-0.104712041884817,0.347368421052632,-0.106260296540362,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","148/150","Q:E:H:K:V:N:P:A:G:S:D",3.09367684201887,7.52888191547387e-12,0.451813758844646,6.84723911447463,9.73717599077908,59.1593944160241,1.34356683555525,6.54726814958295e-16,15.1839398717709,8.90776823243485,65.3653818513773,4.6626285706706e-22,"lineage4","dr_mutations_pyrazinamide","LEU",0,"ERR2510384","ERR2510384","lineage4.9","pk","Pakistan","pnca_p.pro54leu","A","-","PRO","PA54","pnca_complex.pdb"
|
|
"P54L","L4","PZA","P","P54",54,"L",1,"Pre-XDR","DM","hydrophilic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.765,-1.77,-0.0969999999999999,3.46567,-0.95,-0.4,33,66,-0.129,5,5,8,0.050314465408805,"loop",-1.83333333333333,4.91,0.0023717119448037,22.0580357142857,22.0580329576526,22.0491621136906,93.2270586345296,-16,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-10,0,-6,-4,-2,0,-2,-2,-0.448328267477204,-0.0250645994832041,0.126227245245085,-0.161977834612106,-0.104712041884817,0.347368421052632,-0.106260296540362,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","148/150","Q:E:H:K:V:N:P:A:G:S:D",3.09367684201887,7.52888191547387e-12,0.451813758844646,6.84723911447463,9.73717599077908,59.1593944160241,1.34356683555525,6.54726814958295e-16,15.1839398717709,8.90776823243485,65.3653818513773,4.6626285706706e-22,"lineage4","dr_mutations_pyrazinamide","LEU",0,"ERR2510387","ERR2510387","lineage4.9","pk","Pakistan","pnca_p.pro54leu","A","-","PRO","PA54","pnca_complex.pdb"
|
|
"P54L","L2","PZA","P","P54",54,"L",1,"XDR","DM","hydrophilic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.765,-1.77,-0.0969999999999999,3.46567,-0.95,-0.4,33,66,-0.129,5,5,8,0.050314465408805,"loop",-1.83333333333333,4.91,0.0023717119448037,22.0580357142857,22.0580329576526,22.0491621136906,93.2270586345296,-16,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-10,0,-6,-4,-2,0,-2,-2,-0.448328267477204,-0.0250645994832041,0.126227245245085,-0.161977834612106,-0.104712041884817,0.347368421052632,-0.106260296540362,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","148/150","Q:E:H:K:V:N:P:A:G:S:D",3.09367684201887,7.52888191547387e-12,0.451813758844646,6.84723911447463,9.73717599077908,59.1593944160241,1.34356683555525,6.54726814958295e-16,15.1839398717709,8.90776823243485,65.3653818513773,4.6626285706706e-22,"lineage2","dr_mutations_pyrazinamide","LEU",0,"MDR_16401","SRR6824693","lineage2.2.1.1","cn","China: Fugou County, Zhoukou City, Henan Province","pnca_p.pro54leu","A","-","PRO","PA54","pnca_complex.pdb"
|
|
"P54L","L4","PZA","P","P54",54,"L",1,"Pre-XDR","DM","hydrophilic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.765,-1.77,-0.0969999999999999,3.46567,-0.95,-0.4,33,66,-0.129,5,5,8,0.050314465408805,"loop",-1.83333333333333,4.91,0.0023717119448037,22.0580357142857,22.0580329576526,22.0491621136906,93.2270586345296,-16,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-10,0,-6,-4,-2,0,-2,-2,-0.448328267477204,-0.0250645994832041,0.126227245245085,-0.161977834612106,-0.104712041884817,0.347368421052632,-0.106260296540362,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","148/150","Q:E:H:K:V:N:P:A:G:S:D",3.09367684201887,7.52888191547387e-12,0.451813758844646,6.84723911447463,9.73717599077908,59.1593944160241,1.34356683555525,6.54726814958295e-16,15.1839398717709,8.90776823243485,65.3653818513773,4.6626285706706e-22,"lineage4","dr_mutations_pyrazinamide","LEU",0,"ERR2510414","ERR2510414","lineage4.9","pk","Pakistan","pnca_p.pro54leu","A","-","PRO","PA54","pnca_complex.pdb"
|
|
"P54Q","L2","PZA","P","P54",54,"Q",1,"XDR","DM","hydrophilic","hydrophilic","non-polar","neutral","non-polar","polar",9.765,-0.084,-1.251,9.94224,-1.258,-1.64,8,53,-0.129,5,5,8,0.050314465408805,"loop",-1.83333333333333,4.91,0.0003593502946672,19.4256842105263,19.4256680571768,19.4169790983636,9.87561363723508,-16,0,0,0,0,0,0,0,0,-3,0,-1,-2,0,0,0,0,-8,0,-8,-4,-10,0,-8,-6,-0.0212765957446808,-0.323255813953488,0.362118022421492,-0.214492753623188,-0.429319371727749,0.0842105263157895,-0.106260296540362,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","148/150","Q:E:H:K:V:N:P:A:G:S:D",2.96659528728018,0.0079500503166053,1.11770528264822,2.65418382943607,2.872152136516,380.097158975598,1.28837632444196,0.0036816889015929,2.43395291165754,1.92061868691892,951.403114304703,0.0016748373055023,"lineage2","dr_mutations_pyrazinamide","GLN",0,"ERR158587,2129Q-sc-2012-04-10T09:16:19Z-1397799","ERR158587","lineage2.2.1","ru","Russia,Samara","pnca_p.pro54gln","A","-","PRO","PA54","pnca_complex.pdb"
|
|
"P54Q","L4","PZA","P","P54",54,"Q",NA,"MDR","DM","hydrophilic","hydrophilic","non-polar","neutral","non-polar","polar",9.765,-0.084,-1.251,9.94224,-1.258,-1.64,8,53,-0.129,5,5,8,0.050314465408805,"loop",-1.83333333333333,4.91,0.0003593502946672,19.4256842105263,19.4256680571768,19.4169790983636,9.87561363723508,-16,0,0,0,0,0,0,0,0,-3,0,-1,-2,0,0,0,0,-8,0,-8,-4,-10,0,-8,-6,-0.0212765957446808,-0.323255813953488,0.362118022421492,-0.214492753623188,-0.429319371727749,0.0842105263157895,-0.106260296540362,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","148/150","Q:E:H:K:V:N:P:A:G:S:D",2.96659528728018,0.0079500503166053,1.11770528264822,2.65418382943607,2.872152136516,380.097158975598,1.28837632444196,0.0036816889015929,2.43395291165754,1.92061868691892,951.403114304703,0.0016748373055023,"lineage4","dr_mutations_pyrazinamide","GLN",0,"ERR1199145","ERR1199145","lineage4.6.1.1","ug","Uganda","pnca_p.pro54gln","A","-","PRO","PA54","pnca_complex.pdb"
|
|
"P54Q","L2","PZA","P","P54",54,"Q",0,"Pre-XDR","DM","hydrophilic","hydrophilic","non-polar","neutral","non-polar","polar",9.765,-0.084,-1.251,9.94224,-1.258,-1.64,8,53,-0.129,5,5,8,0.050314465408805,"loop",-1.83333333333333,4.91,0.0003593502946672,19.4256842105263,19.4256680571768,19.4169790983636,9.87561363723508,-16,0,0,0,0,0,0,0,0,-3,0,-1,-2,0,0,0,0,-8,0,-8,-4,-10,0,-8,-6,-0.0212765957446808,-0.323255813953488,0.362118022421492,-0.214492753623188,-0.429319371727749,0.0842105263157895,-0.106260296540362,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","148/150","Q:E:H:K:V:N:P:A:G:S:D",2.96659528728018,0.0079500503166053,1.11770528264822,2.65418382943607,2.872152136516,380.097158975598,1.28837632444196,0.0036816889015929,2.43395291165754,1.92061868691892,951.403114304703,0.0016748373055023,"lineage2","dr_mutations_pyrazinamide","GLN",0,"ERS457490","ERR551643_ERR551642","lineage2.2.1","uz","Nukus","pnca_p.pro54gln","A","-","PRO","PA54","pnca_complex.pdb"
|
|
"P54Q","L2","PZA","P","P54",54,"Q",1,"Pre-XDR","DM","hydrophilic","hydrophilic","non-polar","neutral","non-polar","polar",9.765,-0.084,-1.251,9.94224,-1.258,-1.64,8,53,-0.129,5,5,8,0.050314465408805,"loop",-1.83333333333333,4.91,0.0003593502946672,19.4256842105263,19.4256680571768,19.4169790983636,9.87561363723508,-16,0,0,0,0,0,0,0,0,-3,0,-1,-2,0,0,0,0,-8,0,-8,-4,-10,0,-8,-6,-0.0212765957446808,-0.323255813953488,0.362118022421492,-0.214492753623188,-0.429319371727749,0.0842105263157895,-0.106260296540362,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","148/150","Q:E:H:K:V:N:P:A:G:S:D",2.96659528728018,0.0079500503166053,1.11770528264822,2.65418382943607,2.872152136516,380.097158975598,1.28837632444196,0.0036816889015929,2.43395291165754,1.92061868691892,951.403114304703,0.0016748373055023,"lineage2","dr_mutations_pyrazinamide","GLN",0,"ERR067668,0905K-sc-2011-09-07T13:19:43Z-1276515","ERR067668","lineage2.2.1","ru","Russia,Samara","pnca_p.pro54gln","A","-","PRO","PA54","pnca_complex.pdb"
|
|
"P54Q","L2","PZA","P","P54",54,"Q",1,"Pre-XDR","DM","hydrophilic","hydrophilic","non-polar","neutral","non-polar","polar",9.765,-0.084,-1.251,9.94224,-1.258,-1.64,8,53,-0.129,5,5,8,0.050314465408805,"loop",-1.83333333333333,4.91,0.0003593502946672,19.4256842105263,19.4256680571768,19.4169790983636,9.87561363723508,-16,0,0,0,0,0,0,0,0,-3,0,-1,-2,0,0,0,0,-8,0,-8,-4,-10,0,-8,-6,-0.0212765957446808,-0.323255813953488,0.362118022421492,-0.214492753623188,-0.429319371727749,0.0842105263157895,-0.106260296540362,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","148/150","Q:E:H:K:V:N:P:A:G:S:D",2.96659528728018,0.0079500503166053,1.11770528264822,2.65418382943607,2.872152136516,380.097158975598,1.28837632444196,0.0036816889015929,2.43395291165754,1.92061868691892,951.403114304703,0.0016748373055023,"lineage2","dr_mutations_pyrazinamide","GLN",0,"SAMEA2534693,ERS458095","ERR552503_ERR552504","lineage2.2.1","uz","Nukus","pnca_p.pro54gln","A","-","PRO","PA54","pnca_complex.pdb"
|
|
"P54Q","L2","PZA","P","P54",54,"Q",1,"Pre-XDR","DM","hydrophilic","hydrophilic","non-polar","neutral","non-polar","polar",9.765,-0.084,-1.251,9.94224,-1.258,-1.64,8,53,-0.129,5,5,8,0.050314465408805,"loop",-1.83333333333333,4.91,0.0003593502946672,19.4256842105263,19.4256680571768,19.4169790983636,9.87561363723508,-16,0,0,0,0,0,0,0,0,-3,0,-1,-2,0,0,0,0,-8,0,-8,-4,-10,0,-8,-6,-0.0212765957446808,-0.323255813953488,0.362118022421492,-0.214492753623188,-0.429319371727749,0.0842105263157895,-0.106260296540362,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","148/150","Q:E:H:K:V:N:P:A:G:S:D",2.96659528728018,0.0079500503166053,1.11770528264822,2.65418382943607,2.872152136516,380.097158975598,1.28837632444196,0.0036816889015929,2.43395291165754,1.92061868691892,951.403114304703,0.0016748373055023,"lineage2","dr_mutations_pyrazinamide","GLN",0,"ERR144607,2006G-sc-2012-02-21T11:38:12Z-1364844","ERR144607","lineage2.2.1","ru","Russia,Samara","pnca_p.pro54gln","A","-","PRO","PA54","pnca_complex.pdb"
|
|
"P54R","L4","PZA","P","P54",54,"R",1,"Pre-XDR","OM","hydrophilic","hydrophilic","non-polar","basic","non-polar","pos",9.765,-0.957,-0.884,7.06229,-1.269,-0.35,33,66,-0.129,5,5,8,0.050314465408805,"loop",-1.83333333333333,4.91,0.0001437401178668,19.411022297013,511754.463552342,Inf,4.73122070382274,-40,-24,0,0,-24,0,0,0,0,-4,0,0,-4,0,0,0,0,-19,0,-8,-16,-12,0,-12,-12,-0.242401215805471,-0.228423772609819,0.257223974533614,-0.216368286445013,-0.0916230366492146,0.347368421052632,-0.106260296540362,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","148/150","Q:E:H:K:V:N:P:A:G:S:D",13.14560022562,0.924803768446982,139.27718332653,0.0943844491369463,0.0001628371344461,NA,1.28804840845689,0.0292235860951597,1.53426649183163,0.91081598550184,Inf,0.0296198560706035,"lineage4","other_mutations_pyrazinamide","ARG",0,"SAMN10961390","SRR8651581","lineage4.5","cn","China:Wenzhou","pnca_p.pro54arg","A","-","PRO","PA54","pnca_complex.pdb"
|
|
"P54R","L4","PZA","P","P54",54,"R",1,"Pre-XDR","OM","hydrophilic","hydrophilic","non-polar","basic","non-polar","pos",9.765,-0.957,-0.884,7.06229,-1.269,-0.35,33,66,-0.129,5,5,8,0.050314465408805,"loop",-1.83333333333333,4.91,0.0001437401178668,19.411022297013,511754.463552342,Inf,4.73122070382274,-40,-24,0,0,-24,0,0,0,0,-4,0,0,-4,0,0,0,0,-19,0,-8,-16,-12,0,-12,-12,-0.242401215805471,-0.228423772609819,0.257223974533614,-0.216368286445013,-0.0916230366492146,0.347368421052632,-0.106260296540362,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","148/150","Q:E:H:K:V:N:P:A:G:S:D",13.14560022562,0.924803768446982,139.27718332653,0.0943844491369463,0.0001628371344461,NA,1.28804840845689,0.0292235860951597,1.53426649183163,0.91081598550184,Inf,0.0296198560706035,"lineage4","other_mutations_pyrazinamide","ARG",0,"SAMN10961389","SRR8651578","lineage4.5","cn","China:Wenzhou","pnca_p.pro54arg","A","-","PRO","PA54","pnca_complex.pdb"
|
|
"P54S","L2","PZA","P","P54",54,"S",NA,"Pre-XDR","OM","hydrophilic","hydrophilic","non-polar","neutral","non-polar","polar",9.765,-0.307,-1.837,1.58683,-1.286,-1.76,26,63,-0.129,5,5,8,0.050314465408805,"loop",-1.83333333333333,4.91,0.0002156101768003,9.70466975178797,9.70465898653047,9.70194990589383,2.29168245016684,0,-4,0,0,-4,0,0,0,0,-6,0,2,-8,0,0,0,0,-7,0,-3,-2,-6,0,-6,-4,-0.0777608915906788,-0.474677002583979,0.0577958027083531,-0.21926683716965,-0.460732984293194,0.273684210526316,-0.106260296540362,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","148/150","Q:E:H:K:V:N:P:A:G:S:D",2.27260607808816,0.0634455902260904,1.22442760158496,1.8560559033024,0.929172866366028,208.88160300516,0.986980761010679,0.0776844925942494,1.10966566656461,0.504888890842109,570.372842410328,0.130068862702538,"lineage2","other_mutations_pyrazinamide","SER",0,"ERR1023297","ERR1023297","lineage2.2.1","","","pnca_p.pro54ser","A","-","PRO","PA54","pnca_complex.pdb"
|
|
"P54S","L2","PZA","P","P54",54,"S",NA,"MDR","OM","hydrophilic","hydrophilic","non-polar","neutral","non-polar","polar",9.765,-0.307,-1.837,1.58683,-1.286,-1.76,26,63,-0.129,5,5,8,0.050314465408805,"loop",-1.83333333333333,4.91,0.0002156101768003,9.70466975178797,9.70465898653047,9.70194990589383,2.29168245016684,0,-4,0,0,-4,0,0,0,0,-6,0,2,-8,0,0,0,0,-7,0,-3,-2,-6,0,-6,-4,-0.0777608915906788,-0.474677002583979,0.0577958027083531,-0.21926683716965,-0.460732984293194,0.273684210526316,-0.106260296540362,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","148/150","Q:E:H:K:V:N:P:A:G:S:D",2.27260607808816,0.0634455902260904,1.22442760158496,1.8560559033024,0.929172866366028,208.88160300516,0.986980761010679,0.0776844925942494,1.10966566656461,0.504888890842109,570.372842410328,0.130068862702538,"lineage2","other_mutations_pyrazinamide","SER",0,"SRR671748,BGI_FJ05112","SRR671748","lineage2.2.1","cn","China","pnca_p.pro54ser","A","-","PRO","PA54","pnca_complex.pdb"
|
|
"P54S","L2","PZA","P","P54",54,"S",NA,"Pre-XDR","OM","hydrophilic","hydrophilic","non-polar","neutral","non-polar","polar",9.765,-0.307,-1.837,1.58683,-1.286,-1.76,26,63,-0.129,5,5,8,0.050314465408805,"loop",-1.83333333333333,4.91,0.0002156101768003,9.70466975178797,9.70465898653047,9.70194990589383,2.29168245016684,0,-4,0,0,-4,0,0,0,0,-6,0,2,-8,0,0,0,0,-7,0,-3,-2,-6,0,-6,-4,-0.0777608915906788,-0.474677002583979,0.0577958027083531,-0.21926683716965,-0.460732984293194,0.273684210526316,-0.106260296540362,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","148/150","Q:E:H:K:V:N:P:A:G:S:D",2.27260607808816,0.0634455902260904,1.22442760158496,1.8560559033024,0.929172866366028,208.88160300516,0.986980761010679,0.0776844925942494,1.10966566656461,0.504888890842109,570.372842410328,0.130068862702538,"lineage2","other_mutations_pyrazinamide","SER",0,"SRR5067693","SRR5067693","lineage2.2.1","vn","Vietnam","pnca_p.pro54ser","A","-","PRO","PA54","pnca_complex.pdb"
|
|
"P54S","L2","PZA","P","P54",54,"S",NA,"Pre-XDR","OM","hydrophilic","hydrophilic","non-polar","neutral","non-polar","polar",9.765,-0.307,-1.837,1.58683,-1.286,-1.76,26,63,-0.129,5,5,8,0.050314465408805,"loop",-1.83333333333333,4.91,0.0002156101768003,9.70466975178797,9.70465898653047,9.70194990589383,2.29168245016684,0,-4,0,0,-4,0,0,0,0,-6,0,2,-8,0,0,0,0,-7,0,-3,-2,-6,0,-6,-4,-0.0777608915906788,-0.474677002583979,0.0577958027083531,-0.21926683716965,-0.460732984293194,0.273684210526316,-0.106260296540362,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","148/150","Q:E:H:K:V:N:P:A:G:S:D",2.27260607808816,0.0634455902260904,1.22442760158496,1.8560559033024,0.929172866366028,208.88160300516,0.986980761010679,0.0776844925942494,1.10966566656461,0.504888890842109,570.372842410328,0.130068862702538,"lineage2","other_mutations_pyrazinamide","SER",0,"SAMN02414869","SRR1163090_SRR1144823_SRR1163116_SRR1146276","lineage2.2.1","se","Sweden","pnca_p.pro54ser","A","-","PRO","PA54","pnca_complex.pdb"
|
|
"P54S","L2","PZA","P","P54",54,"S",0,"Pre-XDR","OM","hydrophilic","hydrophilic","non-polar","neutral","non-polar","polar",9.765,-0.307,-1.837,1.58683,-1.286,-1.76,26,63,-0.129,5,5,8,0.050314465408805,"loop",-1.83333333333333,4.91,0.0002156101768003,9.70466975178797,9.70465898653047,9.70194990589383,2.29168245016684,0,-4,0,0,-4,0,0,0,0,-6,0,2,-8,0,0,0,0,-7,0,-3,-2,-6,0,-6,-4,-0.0777608915906788,-0.474677002583979,0.0577958027083531,-0.21926683716965,-0.460732984293194,0.273684210526316,-0.106260296540362,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","148/150","Q:E:H:K:V:N:P:A:G:S:D",2.27260607808816,0.0634455902260904,1.22442760158496,1.8560559033024,0.929172866366028,208.88160300516,0.986980761010679,0.0776844925942494,1.10966566656461,0.504888890842109,570.372842410328,0.130068862702538,"lineage2","other_mutations_pyrazinamide","SER",0,"0864Q-sc-2011-10-12T14:58:42Z-1289104,ERR108439","ERR108439","lineage2.2.1","ru","Russia,Samara","pnca_p.pro54ser","A","-","PRO","PA54","pnca_complex.pdb"
|
|
"P54S","L2","PZA","P","P54",54,"S",NA,"MDR","OM","hydrophilic","hydrophilic","non-polar","neutral","non-polar","polar",9.765,-0.307,-1.837,1.58683,-1.286,-1.76,26,63,-0.129,5,5,8,0.050314465408805,"loop",-1.83333333333333,4.91,0.0002156101768003,9.70466975178797,9.70465898653047,9.70194990589383,2.29168245016684,0,-4,0,0,-4,0,0,0,0,-6,0,2,-8,0,0,0,0,-7,0,-3,-2,-6,0,-6,-4,-0.0777608915906788,-0.474677002583979,0.0577958027083531,-0.21926683716965,-0.460732984293194,0.273684210526316,-0.106260296540362,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","148/150","Q:E:H:K:V:N:P:A:G:S:D",2.27260607808816,0.0634455902260904,1.22442760158496,1.8560559033024,0.929172866366028,208.88160300516,0.986980761010679,0.0776844925942494,1.10966566656461,0.504888890842109,570.372842410328,0.130068862702538,"lineage2","other_mutations_pyrazinamide","SER",0,"SRR671727,BGI_A-xz09095","SRR671727","lineage2.2.1","cn","China","pnca_p.pro54ser","A","-","PRO","PA54","pnca_complex.pdb"
|
|
"P54S","L2","PZA","P","P54",54,"S",NA,"XDR","OM","hydrophilic","hydrophilic","non-polar","neutral","non-polar","polar",9.765,-0.307,-1.837,1.58683,-1.286,-1.76,26,63,-0.129,5,5,8,0.050314465408805,"loop",-1.83333333333333,4.91,0.0002156101768003,9.70466975178797,9.70465898653047,9.70194990589383,2.29168245016684,0,-4,0,0,-4,0,0,0,0,-6,0,2,-8,0,0,0,0,-7,0,-3,-2,-6,0,-6,-4,-0.0777608915906788,-0.474677002583979,0.0577958027083531,-0.21926683716965,-0.460732984293194,0.273684210526316,-0.106260296540362,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","148/150","Q:E:H:K:V:N:P:A:G:S:D",2.27260607808816,0.0634455902260904,1.22442760158496,1.8560559033024,0.929172866366028,208.88160300516,0.986980761010679,0.0776844925942494,1.10966566656461,0.504888890842109,570.372842410328,0.130068862702538,"lineage2","other_mutations_pyrazinamide","SER",0,"SRS936022,SAMN03653283","SRR2024983","lineage2.2.1","cn","China","pnca_p.pro54ser","A","-","PRO","PA54","pnca_complex.pdb"
|
|
"P54S","L2","PZA","P","P54",54,"S",NA,"Pre-XDR","OM","hydrophilic","hydrophilic","non-polar","neutral","non-polar","polar",9.765,-0.307,-1.837,1.58683,-1.286,-1.76,26,63,-0.129,5,5,8,0.050314465408805,"loop",-1.83333333333333,4.91,0.0002156101768003,9.70466975178797,9.70465898653047,9.70194990589383,2.29168245016684,0,-4,0,0,-4,0,0,0,0,-6,0,2,-8,0,0,0,0,-7,0,-3,-2,-6,0,-6,-4,-0.0777608915906788,-0.474677002583979,0.0577958027083531,-0.21926683716965,-0.460732984293194,0.273684210526316,-0.106260296540362,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","148/150","Q:E:H:K:V:N:P:A:G:S:D",2.27260607808816,0.0634455902260904,1.22442760158496,1.8560559033024,0.929172866366028,208.88160300516,0.986980761010679,0.0776844925942494,1.10966566656461,0.504888890842109,570.372842410328,0.130068862702538,"lineage2","other_mutations_pyrazinamide","SER",0,"SRS935952,SAMN03653217","SRR2024910","lineage2.2.1","cn","China","pnca_p.pro54ser","A","-","PRO","PA54","pnca_complex.pdb"
|
|
"P54S","L2","PZA","P","P54",54,"S",1,"XDR","OM","hydrophilic","hydrophilic","non-polar","neutral","non-polar","polar",9.765,-0.307,-1.837,1.58683,-1.286,-1.76,26,63,-0.129,5,5,8,0.050314465408805,"loop",-1.83333333333333,4.91,0.0002156101768003,9.70466975178797,9.70465898653047,9.70194990589383,2.29168245016684,0,-4,0,0,-4,0,0,0,0,-6,0,2,-8,0,0,0,0,-7,0,-3,-2,-6,0,-6,-4,-0.0777608915906788,-0.474677002583979,0.0577958027083531,-0.21926683716965,-0.460732984293194,0.273684210526316,-0.106260296540362,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","148/150","Q:E:H:K:V:N:P:A:G:S:D",2.27260607808816,0.0634455902260904,1.22442760158496,1.8560559033024,0.929172866366028,208.88160300516,0.986980761010679,0.0776844925942494,1.10966566656461,0.504888890842109,570.372842410328,0.130068862702538,"lineage2","other_mutations_pyrazinamide","SER",0,"ERS2592781","ERR2677435","lineage2.2.1","de","Germany","pnca_p.pro54ser","A","-","PRO","PA54","pnca_complex.pdb"
|
|
"P54S","L4","PZA","P","P54",54,"S",1,"Pre-XDR","OM","hydrophilic","hydrophilic","non-polar","neutral","non-polar","polar",9.765,-0.307,-1.837,1.58683,-1.286,-1.76,26,63,-0.129,5,5,8,0.050314465408805,"loop",-1.83333333333333,4.91,0.0002156101768003,9.70466975178797,9.70465898653047,9.70194990589383,2.29168245016684,0,-4,0,0,-4,0,0,0,0,-6,0,2,-8,0,0,0,0,-7,0,-3,-2,-6,0,-6,-4,-0.0777608915906788,-0.474677002583979,0.0577958027083531,-0.21926683716965,-0.460732984293194,0.273684210526316,-0.106260296540362,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","148/150","Q:E:H:K:V:N:P:A:G:S:D",2.27260607808816,0.0634455902260904,1.22442760158496,1.8560559033024,0.929172866366028,208.88160300516,0.986980761010679,0.0776844925942494,1.10966566656461,0.504888890842109,570.372842410328,0.130068862702538,"lineage4","other_mutations_pyrazinamide","SER",0,"MDR_18206","SRR6824337","lineage4.5","cn","China: Yongshun County, Xiangxi City, Hunan Province","pnca_p.pro54ser","A","-","PRO","PA54","pnca_complex.pdb"
|
|
"G55S","L4","PZA","G","G55",55,"S",NA,"Sensitive","OM","hydrophobic","hydrophilic","neutral","neutral","non-polar","polar",12.27,0.559,-0.912,0.441313,-1.035,0.06,5,53,-1.036,9,9,36,0.346153846153846,"helix",-1.83333333333333,3.54,NA,NA,NA,NA,NA,0,0,0,0,0,0,0,0,0,-2,0,-2,0,0,0,0,0,-2,0,-4,0,0,0,-3,-7,0.25067264573991,-0.235658914728682,0.01607358008144,-0.176470588235294,0.0337078651685393,0.0526315789473684,-0.85337726523888,"Stabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-1.124,-0.993,"9:9","148/150","T:H:S:A:G",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage4","other_mutations_pyrazinamide","SER",0,"ERR2229463","ERR2229463","lineage4.8","dk","","pnca_p.gly55ser","A","G","GLY","GA55","pnca_complex.pdb"
|
|
"D56E","L2","PZA","D","D56",56,"E",NA,"Sensitive","OM","hydrophilic","hydrophilic","acidic","acidic","neg","neg",11.133,-0.01,0.434,-0.915918,-0.032,0.09,-78,87,2.366,1,1,148,0.766839378238342,"helix",-2.36666666666667,3.47,NA,NA,NA,NA,NA,-8,-4,0,0,-4,0,0,0,0,-1,0,-1,0,0,0,0,0,0,0,0,-1,0,0,0,0,-0.0025329280648429,0.369047619047619,-0.176097439052526,-0.00545609548167093,0.0505617977528089,-0.838709677419355,0.758333333333333,"Destabilising","Stabilising","Stabilising","Destabilising","Stabilising","neutral",1.183,3.125,"1:1","148/150","D:P:S:A:G:T:K:C:R:I:L:V:E:Y",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage2","other_mutations_pyrazinamide","GLU",0,"ERR502510","ERR502510","lineage2","gh","Ghana","pnca_p.asp56glu","A","G","ASP","DA56","pnca_complex.pdb"
|
|
"D56E","L1","PZA","D","D56",56,"E",NA,"Pre-MDR","OM","hydrophilic","hydrophilic","acidic","acidic","neg","neg",11.133,-0.01,0.434,-0.915918,-0.032,0.09,-78,87,2.366,1,1,148,0.766839378238342,"helix",-2.36666666666667,3.47,NA,NA,NA,NA,NA,-8,-4,0,0,-4,0,0,0,0,-1,0,-1,0,0,0,0,0,0,0,0,-1,0,0,0,0,-0.0025329280648429,0.369047619047619,-0.176097439052526,-0.00545609548167093,0.0505617977528089,-0.838709677419355,0.758333333333333,"Destabilising","Stabilising","Stabilising","Destabilising","Stabilising","neutral",1.183,3.125,"1:1","148/150","D:P:S:A:G:T:K:C:R:I:L:V:E:Y",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage1","other_mutations_pyrazinamide","GLU",0,"ERR702404","ERR702404","lineage1","gh","Ghana","pnca_p.asp56glu","A","G","ASP","DA56","pnca_complex.pdb"
|
|
"D56E","","PZA","D","D56",56,"E",NA,"Sensitive","OM","hydrophilic","hydrophilic","acidic","acidic","neg","neg",11.133,-0.01,0.434,-0.915918,-0.032,0.09,-78,87,2.366,1,1,148,0.766839378238342,"helix",-2.36666666666667,3.47,NA,NA,NA,NA,NA,-8,-4,0,0,-4,0,0,0,0,-1,0,-1,0,0,0,0,0,0,0,0,-1,0,0,0,0,-0.0025329280648429,0.369047619047619,-0.176097439052526,-0.00545609548167093,0.0505617977528089,-0.838709677419355,0.758333333333333,"Destabilising","Stabilising","Stabilising","Destabilising","Stabilising","neutral",1.183,3.125,"1:1","148/150","D:P:S:A:G:T:K:C:R:I:L:V:E:Y",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"","other_mutations_pyrazinamide","GLU",0,"ERR502511","ERR502511","","gh","Ghana","pnca_p.asp56glu","A","G","ASP","DA56","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERR3275354","ERR3275354","lineageBOV","nl","Netherlands","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERR751369","ERR751369","lineageBOV","pe","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERR3276244","ERR3276244","lineageBOV","nl","Netherlands","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657514","SRR5657514","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",1,"Pre-XDR","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERR2516252","ERR2516252","lineageBOV","be","Belgium","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",1,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"L49781","SRR1735643","lineageBOV","gb","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657461","SRR5657461","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",1,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERR550755","ERR550755","lineageBOV","","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","L2","PZA","H","H57",57,"D",NA,"XDR","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineage2","dr_mutations_pyrazinamide","ASP",0,"SAMN02419591","SRR1159926_SRR1180924_SRR1159957_SRR1181032","lineage2.2.1","by","Belarus","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657359","SRR5657359","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERR3275485","ERR3275485","lineageBOV","nl","Netherlands","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERR125616","ERR125616","lineageBOV","ie","Ireland","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657374","SRR5657374","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657366","SRR5657366","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657427","SRR5657427","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERR3276025","ERR3276025","lineageBOV","nl","Netherlands","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",1,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERR2514545","ERR2514545","lineageBOV","gb","UK","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",1,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SAMN03648598","SRR2101351","lineageBOV","","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",1,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SAMN07659620","SRR6045019","lineageBOV","gb","UK","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657387","SRR5657387","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657502","SRR5657502","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657435","SRR5657435","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERR3275629","ERR3275629","lineageBOV","nl","Netherlands","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657377","SRR5657377","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERR1035141","ERR1035141","lineageBOV","sa","Saudi Arabia","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",0,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERR2512921","ERR2512921","lineageBOV","gb","UK","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERR2446237","ERR2446237","lineageBOV","nl","Netherlands","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657429","SRR5657429","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",1,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERR2514837","ERR2514837","lineageBOV","gb","UK","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",0,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERR2199797","ERR2199797","lineageBOV","de","Germany","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657361","SRR5657361","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERR551392","ERR551392","lineageBOV","","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERR125628","ERR125628","lineageBOV","ie","Ireland","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",1,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERR2516376","ERR2516376","lineageBOV","be","Belgium","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657527","SRR5657527","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657489","SRR5657489","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",1,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERR2514352","ERR2514352","lineageBOV","gb","UK","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657526","SRR5657526","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657494","SRR5657494","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",1,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERR2512732","ERR2512732","lineageBOV","gb","UK","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657417","SRR5657417","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",1,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERR2517227","ERR2517227","lineageBOV","nl","Netherlands","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERR229952","ERR229952","lineageBOV","ru","Russia","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERR553338","ERR553338","lineageBOV","cg","Congo","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERR3275839","ERR3275839","lineageBOV","nl","Netherlands","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657369","SRR5657369","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657405","SRR5657405","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657445","SRR5657445","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",1,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERR2512570","ERR2512570","lineageBOV","gb","UK","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657497","SRR5657497","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657441","SRR5657441","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERR125623","ERR125623","lineageBOV","ie","Ireland","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERR2446394","ERR2446394","lineageBOV","nl","Netherlands","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657384","SRR5657384","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657446","SRR5657446","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657453","SRR5657453","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",1,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERR046747","ERR046747","lineageBOV","gb","United Kingdom,UK","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657442","SRR5657442","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657464","SRR5657464","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERR125608","ERR125608","lineageBOV","ie","Ireland","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",1,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERR2517518","ERR2517518","lineageBOV","nl","Netherlands","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657457","SRR5657457","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERR2446271","ERR2446271","lineageBOV","nl","Netherlands","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657423","SRR5657423","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",1,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERR2517408","ERR2517408","lineageBOV","nl","Netherlands","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","L2","PZA","H","H57",57,"D",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineage2","dr_mutations_pyrazinamide","ASP",0,"SAMN02419536","SRR1159721_SRR1159780_SRR1181101_SRR1180711","lineage2.2.1","by","Belarus","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657470","SRR5657470","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERR3275788","ERR3275788","lineageBOV","nl","Netherlands","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",1,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERR046989","ERR046989","lineageBOV","gb","United Kingdom,UK","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",1,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERS389418,ERR400460","ERR400460","lineageBOV","","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657419","SRR5657419","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657484","SRR5657484","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERR552138","ERR552138","lineageBOV","cg","Congo","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERR3275346","ERR3275346","lineageBOV","nl","Netherlands","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",1,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERR2514144","ERR2514144","lineageBOV","gb","UK","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERR125621","ERR125621","lineageBOV","ie","Ireland","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",1,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERR046749","ERR046749","lineageBOV","gb","United Kingdom,UK","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",1,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERR2513433","ERR2513433","lineageBOV","gb","UK","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERR125609","ERR125609","lineageBOV","ie","Ireland","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",1,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERR2512838","ERR2512838","lineageBOV","gb","UK","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERR125606","ERR125606","lineageBOV","ie","Ireland","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",1,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERR2515016","ERR2515016","lineageBOV","gb","UK","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERR552470","ERR552470","lineageBOV","cg","Congo","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"XDR","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERR2516453","ERR2516453","lineageBOV","nl","Netherlands","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657462","SRR5657462","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657375","SRR5657375","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657388","SRR5657388","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657404","SRR5657404","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657412","SRR5657412","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657440","SRR5657440","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"NG88","ERR1679654","lineageBOV","ng","Nigeria","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",1,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERR2516311","ERR2516311","lineageBOV","be","Belgium","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657424","SRR5657424","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",1,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERR2516215","ERR2516215","lineageBOV","be","Belgium","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657368","SRR5657368","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657469","SRR5657469","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657402","SRR5657402","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",1,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"H34227","SRR1735703","lineageBOV","gb","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657395","SRR5657395","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657376","SRR5657376","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",1,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERR2514583","ERR2514583","lineageBOV","gb","UK","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657480","SRR5657480","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERR125620","ERR125620","lineageBOV","ie","Ireland","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERR234151","ERR234151","lineageBOV","","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERR2446525","ERR2446525","lineageBOV","nl","Netherlands","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D",NA,"PZA","H","H57",57,"D",1,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineage4;lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERR2517304","ERR2517304","lineageBOV;lineage4.8","nl","Netherlands","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657481","SRR5657481","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657411","SRR5657411","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","L2","PZA","H","H57",57,"D",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineage2","dr_mutations_pyrazinamide","ASP",0,"SAMN02419560","SRR1184040_SRR1159521_SRR1180770_SRR1159526","lineage2.2.1","by","Belarus","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657394","SRR5657394","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","L2","PZA","H","H57",57,"D",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineage2","dr_mutations_pyrazinamide","ASP",0,"SAMN02419685","SRR1168993_SRR1163407_SRR1162977_SRR1172412","lineage2.2.1","by","Belarus","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",1,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERR2516262","ERR2516262","lineageBOV","be","Belgium","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",1,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERR2512956","ERR2512956","lineageBOV","gb","UK","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERR2446533","ERR2446533","lineageBOV","nl","Netherlands","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",1,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERR2515455","ERR2515455","lineageBOV","za","South Africa","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657385","SRR5657385","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",1,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERR2517523","ERR2517523","lineageBOV","nl","Netherlands","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657438","SRR5657438","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657456","SRR5657456","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657392","SRR5657392","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657474","SRR5657474","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",1,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERR2512962","ERR2512962","lineageBOV","gb","UK","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",1,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERR2512755","ERR2512755","lineageBOV","gb","UK","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657360","SRR5657360","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",1,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERR2512931","ERR2512931","lineageBOV","gb","UK","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERR125613","ERR125613","lineageBOV","ie","Ireland","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657428","SRR5657428","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657380","SRR5657380","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657499","SRR5657499","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERR2446363","ERR2446363","lineageBOV","nl","Netherlands","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",1,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERR2516189","ERR2516189","lineageBOV","be","Belgium","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657381","SRR5657381","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657426","SRR5657426","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERR551427","ERR551427","lineageBOV","","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657443","SRR5657443","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERR3275563","ERR3275563","lineageBOV","nl","Netherlands","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERR3276011","ERR3276011","lineageBOV","nl","Netherlands","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657496","SRR5657496","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657491","SRR5657491","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657463","SRR5657463","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",1,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERR2512839","ERR2512839","lineageBOV","gb","UK","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",1,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERR2517368","ERR2517368","lineageBOV","nl","Netherlands","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657396","SRR5657396","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657447","SRR5657447","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",1,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERR2516307","ERR2516307","lineageBOV","be","Belgium","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657504","SRR5657504","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERR125610","ERR125610","lineageBOV","ie","Ireland","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",1,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERR2517425","ERR2517425","lineageBOV","nl","Netherlands","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERR3275977","ERR3275977","lineageBOV","nl","Netherlands","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657367","SRR5657367","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657458","SRR5657458","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",1,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"W37690","SRR1735661","lineageBOV","gb","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERR3275979","ERR3275979","lineageBOV","nl","Netherlands","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657439","SRR5657439","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657515","SRR5657515","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657467","SRR5657467","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657450","SRR5657450","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERR125607","ERR125607","lineageBOV","ie","Ireland","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",1,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERR2513138","ERR2513138","lineageBOV","gb","UK","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657507","SRR5657507","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERR125627","ERR125627","lineageBOV","ie","Ireland","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",1,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERR2517179","ERR2517179","lineageBOV","nl","Netherlands","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",1,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERR2513194","ERR2513194","lineageBOV","gb","UK","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657437","SRR5657437","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",1,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SAMN07660115","SRR6044919","lineageBOV","gb","UK","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657422","SRR5657422","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",1,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERR2517495","ERR2517495","lineageBOV","nl","Netherlands","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERR125617","ERR125617","lineageBOV","ie","Ireland","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERR125624","ERR125624","lineageBOV","ie","Ireland","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657528","SRR5657528","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657509","SRR5657509","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657465","SRR5657465","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657459","SRR5657459","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657466","SRR5657466","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",1,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERR2513302","ERR2513302","lineageBOV","gb","UK","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERR1200622","ERR1200622","lineageBOV","et","Ethiopia","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",1,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERR2515036","ERR2515036","lineageBOV","gb","UK","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657508","SRR5657508","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657448","SRR5657448","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",1,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERR2517443","ERR2517443","lineageBOV","nl","Netherlands","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",1,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"13U175523","SRR3675315","lineageBOV","gb","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERR2446159","ERR2446159","lineageBOV","nl","Netherlands","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",1,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERR2512676","ERR2512676","lineageBOV","gb","UK","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657519","SRR5657519","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERR552515","ERR552515","lineageBOV","cg","Congo","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERR125601","ERR125601","lineageBOV","ie","Ireland","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",1,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERR2513034","ERR2513034","lineageBOV","gb","UK","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",1,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERR553061,SAMEA2535107","ERR553061","lineageBOV","","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERR3275651","ERR3275651","lineageBOV","nl","Netherlands","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",1,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERR2513428","ERR2513428","lineageBOV","gb","UK","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657471","SRR5657471","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",1,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"IMRL16","SRR3675257","lineageBOV","gb","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERR3275231","ERR3275231","lineageBOV","nl","Netherlands","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","L4","PZA","H","H57",57,"D",NA,"MDR","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineage4","dr_mutations_pyrazinamide","ASP",0,"ERR1035293","ERR1035293","lineage4.3.4.2","br","Brazil","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERR125625","ERR125625","lineageBOV","ie","Ireland","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657365","SRR5657365","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",1,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"T62839","SRR1735681","lineageBOV","gb","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657506","SRR5657506","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657373","SRR5657373","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",1,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SAMN07658713","SRR6045235","lineageBOV","gb","UK","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657431","SRR5657431","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",1,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERR2512495","ERR2512495","lineageBOV","gb","UK","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",1,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SAMN03647245,SRR2100072","SRR2100072","lineageBOV","","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657525","SRR5657525","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657476","SRR5657476","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERR125599","ERR125599","lineageBOV","ie","Ireland","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERR3275473","ERR3275473","lineageBOV","nl","Netherlands","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERR125614","ERR125614","lineageBOV","ie","Ireland","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657432","SRR5657432","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR7496578","SRR7496578","lineageBOV","us","Hawaii","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657492","SRR5657492","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657378","SRR5657378","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657391","SRR5657391","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657362","SRR5657362","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657452","SRR5657452","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",1,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERR2513811","ERR2513811","lineageBOV","gb","UK","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERR125615","ERR125615","lineageBOV","ie","Ireland","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657408","SRR5657408","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERR3275571","ERR3275571","lineageBOV","nl","Netherlands","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657498","SRR5657498","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",1,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERR2513607","ERR2513607","lineageBOV","gb","UK","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",1,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SAMN07659425","SRR6046252","lineageBOV","gb","UK","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SAMN02414848","SRR1162747_SRR1166866_SRR1167144_SRR1165461","lineageBOV","se","Sweden","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERR3275288","ERR3275288","lineageBOV","nl","Netherlands","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657407","SRR5657407","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657421","SRR5657421","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",1,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"TB-5","ERR2851358","lineageBOV","lb","Lebanon","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",1,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERR551009,SAMEA2533630","ERR551009","lineageBOV","","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERR125605","ERR125605","lineageBOV","ie","Ireland","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657372","SRR5657372","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657477","SRR5657477","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SAMN07658487","SRR6045827","lineageBOV","gb","UK","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657529","SRR5657529","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657401","SRR5657401","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657416","SRR5657416","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657486","SRR5657486","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","L2","PZA","H","H57",57,"D",NA,"Pre-MDR","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineage2","dr_mutations_pyrazinamide","ASP",0,"SAMN02360606","SRR1013655_SRR1013654_SRR1049050_SRR1049051","lineage2.2.1","kr","South Korea","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657472","SRR5657472","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657488","SRR5657488","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657479","SRR5657479","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657473","SRR5657473","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",1,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERR2517166","ERR2517166","lineageBOV","nl","Netherlands","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",1,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERR2514191","ERR2514191","lineageBOV","gb","UK","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERR2446400","ERR2446400","lineageBOV","nl","Netherlands","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",1,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SAMN07658827","SRR6045214","lineageBOV","gb","UK","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657503","SRR5657503","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",1,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERR2512647","ERR2512647","lineageBOV","gb","UK","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",1,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERR2517349","ERR2517349","lineageBOV","nl","Netherlands","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657490","SRR5657490","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",1,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERR2514979","ERR2514979","lineageBOV","gb","UK","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657512","SRR5657512","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657487","SRR5657487","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERR125619","ERR125619","lineageBOV","ie","Ireland","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657436","SRR5657436","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657397","SRR5657397","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERR125612","ERR125612","lineageBOV","ie","Ireland","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657415","SRR5657415","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657383","SRR5657383","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657363","SRR5657363","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657478","SRR5657478","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",1,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERR2516335","ERR2516335","lineageBOV","be","Belgium","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERR125604","ERR125604","lineageBOV","ie","Ireland","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657386","SRR5657386","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657455","SRR5657455","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERR125626","ERR125626","lineageBOV","ie","Ireland","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657398","SRR5657398","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERR125618","ERR125618","lineageBOV","ie","Ireland","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657406","SRR5657406","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657482","SRR5657482","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",1,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SAMEA2533764,ERR551191","ERR551191","lineageBOV","","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERR125622","ERR125622","lineageBOV","ie","Ireland","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",1,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERR046954","ERR046954","lineageBOV","gb","United Kingdom,UK","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",1,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERR2514087","ERR2514087","lineageBOV","gb","UK","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERR161048","ERR161048","lineageBOV","mw","Malawi","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",1,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERR2512549","ERR2512549","lineageBOV","gb","UK","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",1,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SAMN07660133","SRR6045806","lineageBOV","gb","UK","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657430","SRR5657430","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",1,"XDR","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERR2516545","ERR2516545","lineageBOV","nl","Netherlands","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",1,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERR2517357","ERR2517357","lineageBOV","nl","Netherlands","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",1,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERR046748","ERR046748","lineageBOV","gb","United Kingdom,UK","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","L4","PZA","H","H57",57,"D",1,"MDR","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineage4","dr_mutations_pyrazinamide","ASP",0,"ERR2516985","ERR2516985","lineage4.6.2.2","gb","UK","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657468","SRR5657468","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657518","SRR5657518","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657420","SRR5657420","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657414","SRR5657414","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657400","SRR5657400","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657511","SRR5657511","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657444","SRR5657444","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",1,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"L17046","SRR1735706","lineageBOV","gb","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",1,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERS389344,ERR400386","ERR400386","lineageBOV","","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",1,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERR550954","ERR550954","lineageBOV","","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657517","SRR5657517","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657409","SRR5657409","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERR3275518","ERR3275518","lineageBOV","nl","Netherlands","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657520","SRR5657520","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",1,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERR2514832","ERR2514832","lineageBOV","gb","UK","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657364","SRR5657364","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",1,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERR2512954","ERR2512954","lineageBOV","gb","UK","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657510","SRR5657510","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657433","SRR5657433","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",1,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERR2517151","ERR2517151","lineageBOV","nl","Netherlands","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERR125603","ERR125603","lineageBOV","ie","Ireland","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERR2446502","ERR2446502","lineageBOV","nl","Netherlands","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657516","SRR5657516","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERR2446226","ERR2446226","lineageBOV","nl","Netherlands","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",1,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SAMEA2534289,ERR551917","ERR551917","lineageBOV","","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657382","SRR5657382","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",1,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERR2200072","ERR2200072","lineageBOV","de","Germany","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERR3276208","ERR3276208","lineageBOV","nl","Netherlands","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",1,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERR2512675","ERR2512675","lineageBOV","gb","UK","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",1,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERR551252,SAMEA2533807","ERR551252","lineageBOV","","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",1,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERR2517616","ERR2517616","lineageBOV","nl","Netherlands","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERR212052","ERR212052","lineageBOV","mw","Malawi","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","L2","PZA","H","H57",57,"D",NA,"XDR","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineage2","dr_mutations_pyrazinamide","ASP",0,"SAMN02419636","SRR1172352_SRR1163291_SRR1169108_SRR1163079","lineage2.2.1","by","Belarus","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657434","SRR5657434","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657493","SRR5657493","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657413","SRR5657413","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657371","SRR5657371","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",1,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERR2199785","ERR2199785","lineageBOV","de","Germany","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657370","SRR5657370","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657451","SRR5657451","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",1,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SAMN03647247,SRR2100074","SRR2100074","lineageBOV","","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERR3275793","ERR3275793","lineageBOV","nl","Netherlands","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657501","SRR5657501","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657454","SRR5657454","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657449","SRR5657449","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657379","SRR5657379","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657475","SRR5657475","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",1,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"L17643","SRR1735707","lineageBOV","gb","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657524","SRR5657524","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657523","SRR5657523","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",1,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERR046961","ERR046961","lineageBOV","gb","United Kingdom,UK","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657403","SRR5657403","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERR125602","ERR125602","lineageBOV","ie","Ireland","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657500","SRR5657500","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657460","SRR5657460","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",1,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERR2516207","ERR2516207","lineageBOV","be","Belgium","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERR125600","ERR125600","lineageBOV","ie","Ireland","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657485","SRR5657485","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657389","SRR5657389","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657522","SRR5657522","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657418","SRR5657418","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERR3276190","ERR3276190","lineageBOV","nl","Netherlands","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657483","SRR5657483","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERR3276206","ERR3276206","lineageBOV","nl","Netherlands","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657390","SRR5657390","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERR125611","ERR125611","lineageBOV","ie","Ireland","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",1,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERR2514955","ERR2514955","lineageBOV","gb","UK","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657399","SRR5657399","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERR3275601","ERR3275601","lineageBOV","nl","Netherlands","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657410","SRR5657410","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERR3275892","ERR3275892","lineageBOV","nl","Netherlands","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERR2446335","ERR2446335","lineageBOV","nl","Netherlands","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",1,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERR2516191","ERR2516191","lineageBOV","be","Belgium","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657521","SRR5657521","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERR2446287","ERR2446287","lineageBOV","nl","Netherlands","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657513","SRR5657513","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",1,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"TB-8","ERR2851361","lineageBOV","lb","Lebanon","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657393","SRR5657393","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657495","SRR5657495","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERR2446240","ERR2446240","lineageBOV","nl","Netherlands","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",1,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERR2514285","ERR2514285","lineageBOV","gb","UK","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"ERR125598","ERR125598","lineageBOV","ie","Ireland","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657505","SRR5657505","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657425","SRR5657425","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","L4","PZA","H","H57",57,"D",0,"MDR","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineage4","dr_mutations_pyrazinamide","ASP",0,"ERR2516946","ERR2516946","lineage4.3.3","gb","UK","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57D","LBOV","PZA","H","H57",57,"D",NA,"Other","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.561,-1.283,-1.854,1.83315,-1.011,-1.24,75,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0073307460112117,166.910526315789,166.909698569351,166.066117054134,457.827712322676,12,-52,0,0,-52,0,0,0,0,2,0,0,2,0,0,0,0,0,0,0,2,-2,0,0,0,-0.324974670719352,-0.47906976744186,0.066767313281711,-0.172378516624041,-0.324607329842932,0.789473684210526,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",5.11745293904149,2.3513585122013e-18,0.585586418334624,8.73902259139692,62.7783116073746,679.19417378895,2.2224837265936,2.07661319929242e-72,71.6826443898669,55.3332327668776,812.938834180501,1.42764749548143e-101,"lineageBOV","dr_mutations_pyrazinamide","ASP",0,"SRR5657358","SRR5657358","lineageBOV","mx","","pnca_p.his57asp","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57L","L4","PZA","H","H57",57,"L",NA,"MDR","DM","hydrophobic","hydrophobic","basic","non-polar","pos","non-polar",4.561,-1.924,-0.06,-1.11406,-0.541,-0.64,68,80,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,NA,NA,NA,NA,NA,2,0,0,0,0,0,0,0,0,2,0,0,2,0,0,0,0,0,0,-2,1,0,0,-2,0,-0.487335359675785,-0.0155038759689922,-0.214192878566485,-0.0922421142369992,-0.167539267015707,0.715789473684211,-0.969522240527183,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage4","dr_mutations_pyrazinamide","LEU",0,"ERR751574","ERR751574","lineage4.3.4.2","pe","","pnca_p.his57leu","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57L","L4","PZA","H","H57",57,"L",NA,"MDR","DM","hydrophobic","hydrophobic","basic","non-polar","pos","non-polar",4.561,-1.924,-0.06,-1.11406,-0.541,-0.64,68,80,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,NA,NA,NA,NA,NA,2,0,0,0,0,0,0,0,0,2,0,0,2,0,0,0,0,0,0,-2,1,0,0,-2,0,-0.487335359675785,-0.0155038759689922,-0.214192878566485,-0.0922421142369992,-0.167539267015707,0.715789473684211,-0.969522240527183,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage4","dr_mutations_pyrazinamide","LEU",0,"ERR751597","ERR751597","lineage4.3.4.2","pe","","pnca_p.his57leu","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57L","L4","PZA","H","H57",57,"L",NA,"MDR","DM","hydrophobic","hydrophobic","basic","non-polar","pos","non-polar",4.561,-1.924,-0.06,-1.11406,-0.541,-0.64,68,80,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,NA,NA,NA,NA,NA,2,0,0,0,0,0,0,0,0,2,0,0,2,0,0,0,0,0,0,-2,1,0,0,-2,0,-0.487335359675785,-0.0155038759689922,-0.214192878566485,-0.0922421142369992,-0.167539267015707,0.715789473684211,-0.969522240527183,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage4","dr_mutations_pyrazinamide","LEU",0,"ERR751496","ERR751496","lineage4.3.4.2","pe","","pnca_p.his57leu","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57L","L4","PZA","H","H57",57,"L",NA,"MDR","DM","hydrophobic","hydrophobic","basic","non-polar","pos","non-polar",4.561,-1.924,-0.06,-1.11406,-0.541,-0.64,68,80,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,NA,NA,NA,NA,NA,2,0,0,0,0,0,0,0,0,2,0,0,2,0,0,0,0,0,0,-2,1,0,0,-2,0,-0.487335359675785,-0.0155038759689922,-0.214192878566485,-0.0922421142369992,-0.167539267015707,0.715789473684211,-0.969522240527183,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage4","dr_mutations_pyrazinamide","LEU",0,"ERR751427","ERR751427","lineage4.3.4.2","pe","","pnca_p.his57leu","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57L","L4","PZA","H","H57",57,"L",NA,"MDR","DM","hydrophobic","hydrophobic","basic","non-polar","pos","non-polar",4.561,-1.924,-0.06,-1.11406,-0.541,-0.64,68,80,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,NA,NA,NA,NA,NA,2,0,0,0,0,0,0,0,0,2,0,0,2,0,0,0,0,0,0,-2,1,0,0,-2,0,-0.487335359675785,-0.0155038759689922,-0.214192878566485,-0.0922421142369992,-0.167539267015707,0.715789473684211,-0.969522240527183,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage4","dr_mutations_pyrazinamide","LEU",0,"ERR751559","ERR751559","lineage4.3.4.2","pe","","pnca_p.his57leu","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57P","L4","PZA","H","H57",57,"P",1,"Pre-XDR","DM","hydrophobic","hydrophilic","basic","non-polar","pos","non-polar",4.561,-2.115,-1.226,0.15002,-0.75,-0.33,78,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0002874802357337,38.8547368421053,1392277.50785055,Inf,13.9909822352959,22,0,0,0,0,0,0,0,0,4,2,0,2,0,0,0,0,3,4,-3,4,2,0,0,4,-0.535714285714286,-0.316795865633075,0.00546405495378026,-0.127877237851662,-0.0863874345549738,0.821052631578947,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",14.1464514590952,0.930573112990219,162.371849599067,0.0871237932808301,0.0113995443355766,NA,1.58944397188817,0.0008528275207519,3.06913879340442,3.20302487654751,Inf,0.0001836895199759,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR2510509","ERR2510509","lineage4.1.2.1","pk","Pakistan","pnca_p.his57pro","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57P","L2","PZA","H","H57",57,"P",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","basic","non-polar","pos","non-polar",4.561,-2.115,-1.226,0.15002,-0.75,-0.33,78,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0002874802357337,38.8547368421053,1392277.50785055,Inf,13.9909822352959,22,0,0,0,0,0,0,0,0,4,2,0,2,0,0,0,0,3,4,-3,4,2,0,0,4,-0.535714285714286,-0.316795865633075,0.00546405495378026,-0.127877237851662,-0.0863874345549738,0.821052631578947,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",14.1464514590952,0.930573112990219,162.371849599067,0.0871237932808301,0.0113995443355766,NA,1.58944397188817,0.0008528275207519,3.06913879340442,3.20302487654751,Inf,0.0001836895199759,"lineage2","dr_mutations_pyrazinamide","PRO",0,"ERR1035107","ERR1035107","lineage2.2.1","vn","Vietnam","pnca_p.his57pro","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57P","L2","PZA","H","H57",57,"P",1,"Pre-XDR","DM","hydrophobic","hydrophilic","basic","non-polar","pos","non-polar",4.561,-2.115,-1.226,0.15002,-0.75,-0.33,78,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0002874802357337,38.8547368421053,1392277.50785055,Inf,13.9909822352959,22,0,0,0,0,0,0,0,0,4,2,0,2,0,0,0,0,3,4,-3,4,2,0,0,4,-0.535714285714286,-0.316795865633075,0.00546405495378026,-0.127877237851662,-0.0863874345549738,0.821052631578947,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",14.1464514590952,0.930573112990219,162.371849599067,0.0871237932808301,0.0113995443355766,NA,1.58944397188817,0.0008528275207519,3.06913879340442,3.20302487654751,Inf,0.0001836895199759,"lineage2","dr_mutations_pyrazinamide","PRO",0,"MDR_16517","SRR6824568","lineage2.2.1","cn","China: Nanyang City, Henan Province","pnca_p.his57pro","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57P","L4","PZA","H","H57",57,"P",1,"Pre-XDR","DM","hydrophobic","hydrophilic","basic","non-polar","pos","non-polar",4.561,-2.115,-1.226,0.15002,-0.75,-0.33,78,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0002874802357337,38.8547368421053,1392277.50785055,Inf,13.9909822352959,22,0,0,0,0,0,0,0,0,4,2,0,2,0,0,0,0,3,4,-3,4,2,0,0,4,-0.535714285714286,-0.316795865633075,0.00546405495378026,-0.127877237851662,-0.0863874345549738,0.821052631578947,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",14.1464514590952,0.930573112990219,162.371849599067,0.0871237932808301,0.0113995443355766,NA,1.58944397188817,0.0008528275207519,3.06913879340442,3.20302487654751,Inf,0.0001836895199759,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR2516686","ERR2516686","lineage4.1.1","pe","Peru","pnca_p.his57pro","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57P","L3","PZA","H","H57",57,"P",1,"Pre-XDR","DM","hydrophobic","hydrophilic","basic","non-polar","pos","non-polar",4.561,-2.115,-1.226,0.15002,-0.75,-0.33,78,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0002874802357337,38.8547368421053,1392277.50785055,Inf,13.9909822352959,22,0,0,0,0,0,0,0,0,4,2,0,2,0,0,0,0,3,4,-3,4,2,0,0,4,-0.535714285714286,-0.316795865633075,0.00546405495378026,-0.127877237851662,-0.0863874345549738,0.821052631578947,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",14.1464514590952,0.930573112990219,162.371849599067,0.0871237932808301,0.0113995443355766,NA,1.58944397188817,0.0008528275207519,3.06913879340442,3.20302487654751,Inf,0.0001836895199759,"lineage3","dr_mutations_pyrazinamide","PRO",0,"ERR3335764","ERR3335764","lineage3","pk","Pakistan","pnca_p.his57pro","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57P","L2","PZA","H","H57",57,"P",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","basic","non-polar","pos","non-polar",4.561,-2.115,-1.226,0.15002,-0.75,-0.33,78,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0002874802357337,38.8547368421053,1392277.50785055,Inf,13.9909822352959,22,0,0,0,0,0,0,0,0,4,2,0,2,0,0,0,0,3,4,-3,4,2,0,0,4,-0.535714285714286,-0.316795865633075,0.00546405495378026,-0.127877237851662,-0.0863874345549738,0.821052631578947,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",14.1464514590952,0.930573112990219,162.371849599067,0.0871237932808301,0.0113995443355766,NA,1.58944397188817,0.0008528275207519,3.06913879340442,3.20302487654751,Inf,0.0001836895199759,"lineage2","dr_mutations_pyrazinamide","PRO",0,"ERR1213887","ERR1213887","lineage2.2.1.1","np","Nepal","pnca_p.his57pro","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57Q","L4","PZA","H","H57",57,"Q",NA,"MDR","OM","hydrophobic","hydrophilic","basic","neutral","pos","polar",4.561,-0.949,-1.29,0.84932,-0.454,-0.3,63,80,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,NA,NA,NA,NA,NA,-2,0,0,0,0,0,0,0,0,1,0,-1,2,0,0,0,0,-2,0,-2,2,0,0,-2,-2,-0.240374873353597,-0.333333333333333,0.0309340831445451,-0.0774083546462063,-0.0785340314136125,0.663157894736842,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage4","other_mutations_pyrazinamide","GLN",0,"ERR2707036","ERR2707036","lineage4.3.4.1","cd","Democratic Republic of Congo","pnca_p.his57gln","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57Q","L4","PZA","H","H57",57,"Q",NA,"MDR","OM","hydrophobic","hydrophilic","basic","neutral","pos","polar",4.561,-0.949,-1.29,0.84932,-0.454,-0.3,63,80,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,NA,NA,NA,NA,NA,-2,0,0,0,0,0,0,0,0,1,0,-1,2,0,0,0,0,-2,0,-2,2,0,0,-2,-2,-0.240374873353597,-0.333333333333333,0.0309340831445451,-0.0774083546462063,-0.0785340314136125,0.663157894736842,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage4","other_mutations_pyrazinamide","GLN",0,"ERR2707227","ERR2707227","lineage4.3.4.1","cd","Democratic Republic of Congo","pnca_p.his57gln","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57Q","L4","PZA","H","H57",57,"Q",NA,"MDR","OM","hydrophobic","hydrophilic","basic","neutral","pos","polar",4.561,-0.949,-1.29,0.84932,-0.454,-0.3,63,80,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,NA,NA,NA,NA,NA,-2,0,0,0,0,0,0,0,0,1,0,-1,2,0,0,0,0,-2,0,-2,2,0,0,-2,-2,-0.240374873353597,-0.333333333333333,0.0309340831445451,-0.0774083546462063,-0.0785340314136125,0.663157894736842,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage4","other_mutations_pyrazinamide","GLN",0,"ERR1035302","ERR1035302","lineage4.1.2.1","br","Brazil","pnca_p.his57gln","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57Q","L4","PZA","H","H57",57,"Q",NA,"MDR","OM","hydrophobic","hydrophilic","basic","neutral","pos","polar",4.561,-0.949,-1.29,0.84932,-0.454,-0.3,63,80,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,NA,NA,NA,NA,NA,-2,0,0,0,0,0,0,0,0,1,0,-1,2,0,0,0,0,-2,0,-2,2,0,0,-2,-2,-0.240374873353597,-0.333333333333333,0.0309340831445451,-0.0774083546462063,-0.0785340314136125,0.663157894736842,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage4","other_mutations_pyrazinamide","GLN",0,"ERR2706922","ERR2706922","lineage4.3.4.1","cd","Democratic Republic of Congo","pnca_p.his57gln","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57Q","L4","PZA","H","H57",57,"Q",NA,"Pre-MDR","OM","hydrophobic","hydrophilic","basic","neutral","pos","polar",4.561,-0.949,-1.29,0.84932,-0.454,-0.3,63,80,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,NA,NA,NA,NA,NA,-2,0,0,0,0,0,0,0,0,1,0,-1,2,0,0,0,0,-2,0,-2,2,0,0,-2,-2,-0.240374873353597,-0.333333333333333,0.0309340831445451,-0.0774083546462063,-0.0785340314136125,0.663157894736842,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage4","other_mutations_pyrazinamide","GLN",0,"SRS797394","SRR1723932","lineage4.5","cn","China:Sichuan","pnca_p.his57gln","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57Q","L4","PZA","H","H57",57,"Q",NA,"Pre-MDR","OM","hydrophobic","hydrophilic","basic","neutral","pos","polar",4.561,-0.949,-1.29,0.84932,-0.454,-0.3,63,80,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,NA,NA,NA,NA,NA,-2,0,0,0,0,0,0,0,0,1,0,-1,2,0,0,0,0,-2,0,-2,2,0,0,-2,-2,-0.240374873353597,-0.333333333333333,0.0309340831445451,-0.0774083546462063,-0.0785340314136125,0.663157894736842,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage4","other_mutations_pyrazinamide","GLN",0,"ERR2179675","ERR2179675","lineage4.5","cn","China","pnca_p.his57gln","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57R","L4","PZA","H","H57",57,"R",NA,"MDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",4.561,-0.281,-1.171,1.25273,-0.843,-0.28,76,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0018686215322696,254.917127071823,3820001.12562827,Inf,120.509921037495,-20,-28,0,0,-28,0,0,0,0,2,0,0,2,0,0,0,0,0,0,-2,3,0,0,-2,0,-0.0711752786220871,-0.302583979328165,0.0456271534611995,-0.143734015345269,-0.0732984293193717,0.8,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",15.1557612752498,0.885234541058947,105.0027715034,0.144336773765625,15316.7789338948,20462689243807308,2.40639901531589,1.01650823124183e-20,19.9928891002838,32.1173872780919,Inf,4.89215110948636e-28,"lineage4","dr_mutations_pyrazinamide","ARG",0,"SRR671861,BGI_GuangZ0016","SRR671861","lineage4.4.2","cn","China","pnca_p.his57arg","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57R","L2","PZA","H","H57",57,"R",1,"XDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",4.561,-0.281,-1.171,1.25273,-0.843,-0.28,76,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0018686215322696,254.917127071823,3820001.12562827,Inf,120.509921037495,-20,-28,0,0,-28,0,0,0,0,2,0,0,2,0,0,0,0,0,0,-2,3,0,0,-2,0,-0.0711752786220871,-0.302583979328165,0.0456271534611995,-0.143734015345269,-0.0732984293193717,0.8,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",15.1557612752498,0.885234541058947,105.0027715034,0.144336773765625,15316.7789338948,20462689243807308,2.40639901531589,1.01650823124183e-20,19.9928891002838,32.1173872780919,Inf,4.89215110948636e-28,"lineage2","dr_mutations_pyrazinamide","ARG",0,"ERR2516772","ERR2516772","lineage2.2.1","gb","UK","pnca_p.his57arg","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57R","L4","PZA","H","H57",57,"R",1,"MDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",4.561,-0.281,-1.171,1.25273,-0.843,-0.28,76,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0018686215322696,254.917127071823,3820001.12562827,Inf,120.509921037495,-20,-28,0,0,-28,0,0,0,0,2,0,0,2,0,0,0,0,0,0,-2,3,0,0,-2,0,-0.0711752786220871,-0.302583979328165,0.0456271534611995,-0.143734015345269,-0.0732984293193717,0.8,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",15.1557612752498,0.885234541058947,105.0027715034,0.144336773765625,15316.7789338948,20462689243807308,2.40639901531589,1.01650823124183e-20,19.9928891002838,32.1173872780919,Inf,4.89215110948636e-28,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERR2041791","ERR2041791","lineage4.2.2.1","rs","Serbia","pnca_p.his57arg","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57R","L2","PZA","H","H57",57,"R",1,"XDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",4.561,-0.281,-1.171,1.25273,-0.843,-0.28,76,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0018686215322696,254.917127071823,3820001.12562827,Inf,120.509921037495,-20,-28,0,0,-28,0,0,0,0,2,0,0,2,0,0,0,0,0,0,-2,3,0,0,-2,0,-0.0711752786220871,-0.302583979328165,0.0456271534611995,-0.143734015345269,-0.0732984293193717,0.8,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",15.1557612752498,0.885234541058947,105.0027715034,0.144336773765625,15316.7789338948,20462689243807308,2.40639901531589,1.01650823124183e-20,19.9928891002838,32.1173872780919,Inf,4.89215110948636e-28,"lineage2","dr_mutations_pyrazinamide","ARG",0,"ERR2516308","ERR2516308","lineage2.2.1","be","Belgium","pnca_p.his57arg","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57R","L2","PZA","H","H57",57,"R",1,"Pre-XDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",4.561,-0.281,-1.171,1.25273,-0.843,-0.28,76,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0018686215322696,254.917127071823,3820001.12562827,Inf,120.509921037495,-20,-28,0,0,-28,0,0,0,0,2,0,0,2,0,0,0,0,0,0,-2,3,0,0,-2,0,-0.0711752786220871,-0.302583979328165,0.0456271534611995,-0.143734015345269,-0.0732984293193717,0.8,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",15.1557612752498,0.885234541058947,105.0027715034,0.144336773765625,15316.7789338948,20462689243807308,2.40639901531589,1.01650823124183e-20,19.9928891002838,32.1173872780919,Inf,4.89215110948636e-28,"lineage2","dr_mutations_pyrazinamide","ARG",0,"ERR2516787","ERR2516787","lineage2.2.1","gb","UK","pnca_p.his57arg","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57R","L2","PZA","H","H57",57,"R",NA,"XDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",4.561,-0.281,-1.171,1.25273,-0.843,-0.28,76,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0018686215322696,254.917127071823,3820001.12562827,Inf,120.509921037495,-20,-28,0,0,-28,0,0,0,0,2,0,0,2,0,0,0,0,0,0,-2,3,0,0,-2,0,-0.0711752786220871,-0.302583979328165,0.0456271534611995,-0.143734015345269,-0.0732984293193717,0.8,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",15.1557612752498,0.885234541058947,105.0027715034,0.144336773765625,15316.7789338948,20462689243807308,2.40639901531589,1.01650823124183e-20,19.9928891002838,32.1173872780919,Inf,4.89215110948636e-28,"lineage2","dr_mutations_pyrazinamide","ARG",0,"ERR2516806","ERR2516806","lineage2.2.1","gb","UK","pnca_p.his57arg","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57R","L2","PZA","H","H57",57,"R",NA,"XDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",4.561,-0.281,-1.171,1.25273,-0.843,-0.28,76,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0018686215322696,254.917127071823,3820001.12562827,Inf,120.509921037495,-20,-28,0,0,-28,0,0,0,0,2,0,0,2,0,0,0,0,0,0,-2,3,0,0,-2,0,-0.0711752786220871,-0.302583979328165,0.0456271534611995,-0.143734015345269,-0.0732984293193717,0.8,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",15.1557612752498,0.885234541058947,105.0027715034,0.144336773765625,15316.7789338948,20462689243807308,2.40639901531589,1.01650823124183e-20,19.9928891002838,32.1173872780919,Inf,4.89215110948636e-28,"lineage2","dr_mutations_pyrazinamide","ARG",0,"SAMN07658846","SRR6045537","lineage2.2.1","gb","UK","pnca_p.his57arg","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57R","L2","PZA","H","H57",57,"R",1,"Pre-XDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",4.561,-0.281,-1.171,1.25273,-0.843,-0.28,76,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0018686215322696,254.917127071823,3820001.12562827,Inf,120.509921037495,-20,-28,0,0,-28,0,0,0,0,2,0,0,2,0,0,0,0,0,0,-2,3,0,0,-2,0,-0.0711752786220871,-0.302583979328165,0.0456271534611995,-0.143734015345269,-0.0732984293193717,0.8,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",15.1557612752498,0.885234541058947,105.0027715034,0.144336773765625,15316.7789338948,20462689243807308,2.40639901531589,1.01650823124183e-20,19.9928891002838,32.1173872780919,Inf,4.89215110948636e-28,"lineage2","dr_mutations_pyrazinamide","ARG",0,"ERR2517118","ERR2517118","lineage2.2.1","gb","UK","pnca_p.his57arg","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57R","L2","PZA","H","H57",57,"R",NA,"XDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",4.561,-0.281,-1.171,1.25273,-0.843,-0.28,76,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0018686215322696,254.917127071823,3820001.12562827,Inf,120.509921037495,-20,-28,0,0,-28,0,0,0,0,2,0,0,2,0,0,0,0,0,0,-2,3,0,0,-2,0,-0.0711752786220871,-0.302583979328165,0.0456271534611995,-0.143734015345269,-0.0732984293193717,0.8,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",15.1557612752498,0.885234541058947,105.0027715034,0.144336773765625,15316.7789338948,20462689243807308,2.40639901531589,1.01650823124183e-20,19.9928891002838,32.1173872780919,Inf,4.89215110948636e-28,"lineage2","dr_mutations_pyrazinamide","ARG",0,"SAMN07660441","SRR6046574","lineage2.2.1","gb","UK","pnca_p.his57arg","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57R","L4","PZA","H","H57",57,"R",NA,"MDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",4.561,-0.281,-1.171,1.25273,-0.843,-0.28,76,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0018686215322696,254.917127071823,3820001.12562827,Inf,120.509921037495,-20,-28,0,0,-28,0,0,0,0,2,0,0,2,0,0,0,0,0,0,-2,3,0,0,-2,0,-0.0711752786220871,-0.302583979328165,0.0456271534611995,-0.143734015345269,-0.0732984293193717,0.8,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",15.1557612752498,0.885234541058947,105.0027715034,0.144336773765625,15316.7789338948,20462689243807308,2.40639901531589,1.01650823124183e-20,19.9928891002838,32.1173872780919,Inf,4.89215110948636e-28,"lineage4","dr_mutations_pyrazinamide","ARG",0,"SRR671725,BGI_GuangZ6","SRR671725","lineage4.4.2","cn","China","pnca_p.his57arg","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57R","L2","PZA","H","H57",57,"R",1,"XDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",4.561,-0.281,-1.171,1.25273,-0.843,-0.28,76,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0018686215322696,254.917127071823,3820001.12562827,Inf,120.509921037495,-20,-28,0,0,-28,0,0,0,0,2,0,0,2,0,0,0,0,0,0,-2,3,0,0,-2,0,-0.0711752786220871,-0.302583979328165,0.0456271534611995,-0.143734015345269,-0.0732984293193717,0.8,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",15.1557612752498,0.885234541058947,105.0027715034,0.144336773765625,15316.7789338948,20462689243807308,2.40639901531589,1.01650823124183e-20,19.9928891002838,32.1173872780919,Inf,4.89215110948636e-28,"lineage2","dr_mutations_pyrazinamide","ARG",0,"ERR2517016","ERR2517016","lineage2.2.1","gb","UK","pnca_p.his57arg","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57R","L2","PZA","H","H57",57,"R",1,"XDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",4.561,-0.281,-1.171,1.25273,-0.843,-0.28,76,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0018686215322696,254.917127071823,3820001.12562827,Inf,120.509921037495,-20,-28,0,0,-28,0,0,0,0,2,0,0,2,0,0,0,0,0,0,-2,3,0,0,-2,0,-0.0711752786220871,-0.302583979328165,0.0456271534611995,-0.143734015345269,-0.0732984293193717,0.8,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",15.1557612752498,0.885234541058947,105.0027715034,0.144336773765625,15316.7789338948,20462689243807308,2.40639901531589,1.01650823124183e-20,19.9928891002838,32.1173872780919,Inf,4.89215110948636e-28,"lineage2","dr_mutations_pyrazinamide","ARG",0,"ERR2516196","ERR2516196","lineage2.2.1","be","Belgium","pnca_p.his57arg","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57R","L2","PZA","H","H57",57,"R",1,"XDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",4.561,-0.281,-1.171,1.25273,-0.843,-0.28,76,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0018686215322696,254.917127071823,3820001.12562827,Inf,120.509921037495,-20,-28,0,0,-28,0,0,0,0,2,0,0,2,0,0,0,0,0,0,-2,3,0,0,-2,0,-0.0711752786220871,-0.302583979328165,0.0456271534611995,-0.143734015345269,-0.0732984293193717,0.8,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",15.1557612752498,0.885234541058947,105.0027715034,0.144336773765625,15316.7789338948,20462689243807308,2.40639901531589,1.01650823124183e-20,19.9928891002838,32.1173872780919,Inf,4.89215110948636e-28,"lineage2","dr_mutations_pyrazinamide","ARG",0,"SAMN03648003,SRR2100830","SRR2100830","lineage2.2.1","","","pnca_p.his57arg","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57R","L2","PZA","H","H57",57,"R",1,"Pre-XDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",4.561,-0.281,-1.171,1.25273,-0.843,-0.28,76,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0018686215322696,254.917127071823,3820001.12562827,Inf,120.509921037495,-20,-28,0,0,-28,0,0,0,0,2,0,0,2,0,0,0,0,0,0,-2,3,0,0,-2,0,-0.0711752786220871,-0.302583979328165,0.0456271534611995,-0.143734015345269,-0.0732984293193717,0.8,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",15.1557612752498,0.885234541058947,105.0027715034,0.144336773765625,15316.7789338948,20462689243807308,2.40639901531589,1.01650823124183e-20,19.9928891002838,32.1173872780919,Inf,4.89215110948636e-28,"lineage2","dr_mutations_pyrazinamide","ARG",0,"ERR2516872","ERR2516872","lineage2.2.1","gb","UK","pnca_p.his57arg","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57R","L2","PZA","H","H57",57,"R",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",4.561,-0.281,-1.171,1.25273,-0.843,-0.28,76,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0018686215322696,254.917127071823,3820001.12562827,Inf,120.509921037495,-20,-28,0,0,-28,0,0,0,0,2,0,0,2,0,0,0,0,0,0,-2,3,0,0,-2,0,-0.0711752786220871,-0.302583979328165,0.0456271534611995,-0.143734015345269,-0.0732984293193717,0.8,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",15.1557612752498,0.885234541058947,105.0027715034,0.144336773765625,15316.7789338948,20462689243807308,2.40639901531589,1.01650823124183e-20,19.9928891002838,32.1173872780919,Inf,4.89215110948636e-28,"lineage2","dr_mutations_pyrazinamide","ARG",0,"ERR2516921","ERR2516921","lineage2.2.1","gb","UK","pnca_p.his57arg","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57R","L2","PZA","H","H57",57,"R",1,"Pre-XDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",4.561,-0.281,-1.171,1.25273,-0.843,-0.28,76,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0018686215322696,254.917127071823,3820001.12562827,Inf,120.509921037495,-20,-28,0,0,-28,0,0,0,0,2,0,0,2,0,0,0,0,0,0,-2,3,0,0,-2,0,-0.0711752786220871,-0.302583979328165,0.0456271534611995,-0.143734015345269,-0.0732984293193717,0.8,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",15.1557612752498,0.885234541058947,105.0027715034,0.144336773765625,15316.7789338948,20462689243807308,2.40639901531589,1.01650823124183e-20,19.9928891002838,32.1173872780919,Inf,4.89215110948636e-28,"lineage2","dr_mutations_pyrazinamide","ARG",0,"ERR2513786","ERR2513786","lineage2.2.1","gb","UK","pnca_p.his57arg","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57R","L2","PZA","H","H57",57,"R",1,"XDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",4.561,-0.281,-1.171,1.25273,-0.843,-0.28,76,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0018686215322696,254.917127071823,3820001.12562827,Inf,120.509921037495,-20,-28,0,0,-28,0,0,0,0,2,0,0,2,0,0,0,0,0,0,-2,3,0,0,-2,0,-0.0711752786220871,-0.302583979328165,0.0456271534611995,-0.143734015345269,-0.0732984293193717,0.8,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",15.1557612752498,0.885234541058947,105.0027715034,0.144336773765625,15316.7789338948,20462689243807308,2.40639901531589,1.01650823124183e-20,19.9928891002838,32.1173872780919,Inf,4.89215110948636e-28,"lineage2","dr_mutations_pyrazinamide","ARG",0,"ERR2516926","ERR2516926","lineage2.2.1","gb","UK","pnca_p.his57arg","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57R","L2","PZA","H","H57",57,"R",1,"Pre-XDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",4.561,-0.281,-1.171,1.25273,-0.843,-0.28,76,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0018686215322696,254.917127071823,3820001.12562827,Inf,120.509921037495,-20,-28,0,0,-28,0,0,0,0,2,0,0,2,0,0,0,0,0,0,-2,3,0,0,-2,0,-0.0711752786220871,-0.302583979328165,0.0456271534611995,-0.143734015345269,-0.0732984293193717,0.8,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",15.1557612752498,0.885234541058947,105.0027715034,0.144336773765625,15316.7789338948,20462689243807308,2.40639901531589,1.01650823124183e-20,19.9928891002838,32.1173872780919,Inf,4.89215110948636e-28,"lineage2","dr_mutations_pyrazinamide","ARG",0,"ERR2516998","ERR2516998","lineage2.2.1","gb","UK","pnca_p.his57arg","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57R","L2","PZA","H","H57",57,"R",NA,"XDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",4.561,-0.281,-1.171,1.25273,-0.843,-0.28,76,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0018686215322696,254.917127071823,3820001.12562827,Inf,120.509921037495,-20,-28,0,0,-28,0,0,0,0,2,0,0,2,0,0,0,0,0,0,-2,3,0,0,-2,0,-0.0711752786220871,-0.302583979328165,0.0456271534611995,-0.143734015345269,-0.0732984293193717,0.8,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",15.1557612752498,0.885234541058947,105.0027715034,0.144336773765625,15316.7789338948,20462689243807308,2.40639901531589,1.01650823124183e-20,19.9928891002838,32.1173872780919,Inf,4.89215110948636e-28,"lineage2","dr_mutations_pyrazinamide","ARG",0,"SAMN07659468","SRR6045763","lineage2.2.1","gb","UK","pnca_p.his57arg","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57R","L4","PZA","H","H57",57,"R",1,"Pre-XDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",4.561,-0.281,-1.171,1.25273,-0.843,-0.28,76,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0018686215322696,254.917127071823,3820001.12562827,Inf,120.509921037495,-20,-28,0,0,-28,0,0,0,0,2,0,0,2,0,0,0,0,0,0,-2,3,0,0,-2,0,-0.0711752786220871,-0.302583979328165,0.0456271534611995,-0.143734015345269,-0.0732984293193717,0.8,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",15.1557612752498,0.885234541058947,105.0027715034,0.144336773765625,15316.7789338948,20462689243807308,2.40639901531589,1.01650823124183e-20,19.9928891002838,32.1173872780919,Inf,4.89215110948636e-28,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERR1034785","ERR1034785","lineage4.1.2.1","pe","Peru","pnca_p.his57arg","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57R","L2","PZA","H","H57",57,"R",1,"Pre-XDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",4.561,-0.281,-1.171,1.25273,-0.843,-0.28,76,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0018686215322696,254.917127071823,3820001.12562827,Inf,120.509921037495,-20,-28,0,0,-28,0,0,0,0,2,0,0,2,0,0,0,0,0,0,-2,3,0,0,-2,0,-0.0711752786220871,-0.302583979328165,0.0456271534611995,-0.143734015345269,-0.0732984293193717,0.8,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",15.1557612752498,0.885234541058947,105.0027715034,0.144336773765625,15316.7789338948,20462689243807308,2.40639901531589,1.01650823124183e-20,19.9928891002838,32.1173872780919,Inf,4.89215110948636e-28,"lineage2","dr_mutations_pyrazinamide","ARG",0,"SRR2101055,SAMN03648302","SRR2101055","lineage2.2.1","","","pnca_p.his57arg","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57R","L4","PZA","H","H57",57,"R",1,"MDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",4.561,-0.281,-1.171,1.25273,-0.843,-0.28,76,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0018686215322696,254.917127071823,3820001.12562827,Inf,120.509921037495,-20,-28,0,0,-28,0,0,0,0,2,0,0,2,0,0,0,0,0,0,-2,3,0,0,-2,0,-0.0711752786220871,-0.302583979328165,0.0456271534611995,-0.143734015345269,-0.0732984293193717,0.8,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",15.1557612752498,0.885234541058947,105.0027715034,0.144336773765625,15316.7789338948,20462689243807308,2.40639901531589,1.01650823124183e-20,19.9928891002838,32.1173872780919,Inf,4.89215110948636e-28,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERR2041734","ERR2041734","lineage4.2.2.1","rs","Serbia","pnca_p.his57arg","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57R","L2","PZA","H","H57",57,"R",1,"Pre-XDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",4.561,-0.281,-1.171,1.25273,-0.843,-0.28,76,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0018686215322696,254.917127071823,3820001.12562827,Inf,120.509921037495,-20,-28,0,0,-28,0,0,0,0,2,0,0,2,0,0,0,0,0,0,-2,3,0,0,-2,0,-0.0711752786220871,-0.302583979328165,0.0456271534611995,-0.143734015345269,-0.0732984293193717,0.8,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",15.1557612752498,0.885234541058947,105.0027715034,0.144336773765625,15316.7789338948,20462689243807308,2.40639901531589,1.01650823124183e-20,19.9928891002838,32.1173872780919,Inf,4.89215110948636e-28,"lineage2","dr_mutations_pyrazinamide","ARG",0,"ERR2517011","ERR2517011","lineage2.2.1","gb","UK","pnca_p.his57arg","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57R","L2","PZA","H","H57",57,"R",1,"Pre-XDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",4.561,-0.281,-1.171,1.25273,-0.843,-0.28,76,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0018686215322696,254.917127071823,3820001.12562827,Inf,120.509921037495,-20,-28,0,0,-28,0,0,0,0,2,0,0,2,0,0,0,0,0,0,-2,3,0,0,-2,0,-0.0711752786220871,-0.302583979328165,0.0456271534611995,-0.143734015345269,-0.0732984293193717,0.8,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",15.1557612752498,0.885234541058947,105.0027715034,0.144336773765625,15316.7789338948,20462689243807308,2.40639901531589,1.01650823124183e-20,19.9928891002838,32.1173872780919,Inf,4.89215110948636e-28,"lineage2","dr_mutations_pyrazinamide","ARG",0,"ERR2516891","ERR2516891","lineage2.2.1","gb","UK","pnca_p.his57arg","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57R","L4","PZA","H","H57",57,"R",1,"MDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",4.561,-0.281,-1.171,1.25273,-0.843,-0.28,76,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0018686215322696,254.917127071823,3820001.12562827,Inf,120.509921037495,-20,-28,0,0,-28,0,0,0,0,2,0,0,2,0,0,0,0,0,0,-2,3,0,0,-2,0,-0.0711752786220871,-0.302583979328165,0.0456271534611995,-0.143734015345269,-0.0732984293193717,0.8,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",15.1557612752498,0.885234541058947,105.0027715034,0.144336773765625,15316.7789338948,20462689243807308,2.40639901531589,1.01650823124183e-20,19.9928891002838,32.1173872780919,Inf,4.89215110948636e-28,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERR2041796","ERR2041796","lineage4.2.2.1","rs","Serbia","pnca_p.his57arg","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57R","L2","PZA","H","H57",57,"R",NA,"XDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",4.561,-0.281,-1.171,1.25273,-0.843,-0.28,76,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0018686215322696,254.917127071823,3820001.12562827,Inf,120.509921037495,-20,-28,0,0,-28,0,0,0,0,2,0,0,2,0,0,0,0,0,0,-2,3,0,0,-2,0,-0.0711752786220871,-0.302583979328165,0.0456271534611995,-0.143734015345269,-0.0732984293193717,0.8,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",15.1557612752498,0.885234541058947,105.0027715034,0.144336773765625,15316.7789338948,20462689243807308,2.40639901531589,1.01650823124183e-20,19.9928891002838,32.1173872780919,Inf,4.89215110948636e-28,"lineage2","dr_mutations_pyrazinamide","ARG",0,"ERR158608","ERR158608","lineage2.2.1","gb","UK","pnca_p.his57arg","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57R","L2","PZA","H","H57",57,"R",1,"Pre-XDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",4.561,-0.281,-1.171,1.25273,-0.843,-0.28,76,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0018686215322696,254.917127071823,3820001.12562827,Inf,120.509921037495,-20,-28,0,0,-28,0,0,0,0,2,0,0,2,0,0,0,0,0,0,-2,3,0,0,-2,0,-0.0711752786220871,-0.302583979328165,0.0456271534611995,-0.143734015345269,-0.0732984293193717,0.8,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",15.1557612752498,0.885234541058947,105.0027715034,0.144336773765625,15316.7789338948,20462689243807308,2.40639901531589,1.01650823124183e-20,19.9928891002838,32.1173872780919,Inf,4.89215110948636e-28,"lineage2","dr_mutations_pyrazinamide","ARG",0,"ERR2516983","ERR2516983","lineage2.2.1","gb","UK","pnca_p.his57arg","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57R","L2","PZA","H","H57",57,"R",1,"XDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",4.561,-0.281,-1.171,1.25273,-0.843,-0.28,76,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0018686215322696,254.917127071823,3820001.12562827,Inf,120.509921037495,-20,-28,0,0,-28,0,0,0,0,2,0,0,2,0,0,0,0,0,0,-2,3,0,0,-2,0,-0.0711752786220871,-0.302583979328165,0.0456271534611995,-0.143734015345269,-0.0732984293193717,0.8,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",15.1557612752498,0.885234541058947,105.0027715034,0.144336773765625,15316.7789338948,20462689243807308,2.40639901531589,1.01650823124183e-20,19.9928891002838,32.1173872780919,Inf,4.89215110948636e-28,"lineage2","dr_mutations_pyrazinamide","ARG",0,"ERS2592778","ERR2677431","lineage2.2.1","de","Germany","pnca_p.his57arg","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57R","L2","PZA","H","H57",57,"R",1,"XDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",4.561,-0.281,-1.171,1.25273,-0.843,-0.28,76,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0018686215322696,254.917127071823,3820001.12562827,Inf,120.509921037495,-20,-28,0,0,-28,0,0,0,0,2,0,0,2,0,0,0,0,0,0,-2,3,0,0,-2,0,-0.0711752786220871,-0.302583979328165,0.0456271534611995,-0.143734015345269,-0.0732984293193717,0.8,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",15.1557612752498,0.885234541058947,105.0027715034,0.144336773765625,15316.7789338948,20462689243807308,2.40639901531589,1.01650823124183e-20,19.9928891002838,32.1173872780919,Inf,4.89215110948636e-28,"lineage2","dr_mutations_pyrazinamide","ARG",0,"SAMN07660377","SRR6045085","lineage2.2.1","gb","UK","pnca_p.his57arg","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57R","L4","PZA","H","H57",57,"R",1,"MDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",4.561,-0.281,-1.171,1.25273,-0.843,-0.28,76,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0018686215322696,254.917127071823,3820001.12562827,Inf,120.509921037495,-20,-28,0,0,-28,0,0,0,0,2,0,0,2,0,0,0,0,0,0,-2,3,0,0,-2,0,-0.0711752786220871,-0.302583979328165,0.0456271534611995,-0.143734015345269,-0.0732984293193717,0.8,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",15.1557612752498,0.885234541058947,105.0027715034,0.144336773765625,15316.7789338948,20462689243807308,2.40639901531589,1.01650823124183e-20,19.9928891002838,32.1173872780919,Inf,4.89215110948636e-28,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERR2041738","ERR2041738","lineage4.2.2.1","rs","Serbia","pnca_p.his57arg","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57R","L2","PZA","H","H57",57,"R",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",4.561,-0.281,-1.171,1.25273,-0.843,-0.28,76,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0018686215322696,254.917127071823,3820001.12562827,Inf,120.509921037495,-20,-28,0,0,-28,0,0,0,0,2,0,0,2,0,0,0,0,0,0,-2,3,0,0,-2,0,-0.0711752786220871,-0.302583979328165,0.0456271534611995,-0.143734015345269,-0.0732984293193717,0.8,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",15.1557612752498,0.885234541058947,105.0027715034,0.144336773765625,15316.7789338948,20462689243807308,2.40639901531589,1.01650823124183e-20,19.9928891002838,32.1173872780919,Inf,4.89215110948636e-28,"lineage2","dr_mutations_pyrazinamide","ARG",0,"ERR2516765","ERR2516765","lineage2.2.1","gb","UK","pnca_p.his57arg","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57R","L4","PZA","H","H57",57,"R",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",4.561,-0.281,-1.171,1.25273,-0.843,-0.28,76,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0018686215322696,254.917127071823,3820001.12562827,Inf,120.509921037495,-20,-28,0,0,-28,0,0,0,0,2,0,0,2,0,0,0,0,0,0,-2,3,0,0,-2,0,-0.0711752786220871,-0.302583979328165,0.0456271534611995,-0.143734015345269,-0.0732984293193717,0.8,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",15.1557612752498,0.885234541058947,105.0027715034,0.144336773765625,15316.7789338948,20462689243807308,2.40639901531589,1.01650823124183e-20,19.9928891002838,32.1173872780919,Inf,4.89215110948636e-28,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERR751467","ERR751467","lineage4.1.2.1","pe","","pnca_p.his57arg","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57R","L2","PZA","H","H57",57,"R",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",4.561,-0.281,-1.171,1.25273,-0.843,-0.28,76,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0018686215322696,254.917127071823,3820001.12562827,Inf,120.509921037495,-20,-28,0,0,-28,0,0,0,0,2,0,0,2,0,0,0,0,0,0,-2,3,0,0,-2,0,-0.0711752786220871,-0.302583979328165,0.0456271534611995,-0.143734015345269,-0.0732984293193717,0.8,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",15.1557612752498,0.885234541058947,105.0027715034,0.144336773765625,15316.7789338948,20462689243807308,2.40639901531589,1.01650823124183e-20,19.9928891002838,32.1173872780919,Inf,4.89215110948636e-28,"lineage2","dr_mutations_pyrazinamide","ARG",0,"ERR2516922","ERR2516922","lineage2.2.1","gb","UK","pnca_p.his57arg","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57R","L4","PZA","H","H57",57,"R",1,"MDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",4.561,-0.281,-1.171,1.25273,-0.843,-0.28,76,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0018686215322696,254.917127071823,3820001.12562827,Inf,120.509921037495,-20,-28,0,0,-28,0,0,0,0,2,0,0,2,0,0,0,0,0,0,-2,3,0,0,-2,0,-0.0711752786220871,-0.302583979328165,0.0456271534611995,-0.143734015345269,-0.0732984293193717,0.8,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",15.1557612752498,0.885234541058947,105.0027715034,0.144336773765625,15316.7789338948,20462689243807308,2.40639901531589,1.01650823124183e-20,19.9928891002838,32.1173872780919,Inf,4.89215110948636e-28,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERR2041712","ERR2041712","lineage4.2.2.1","rs","Serbia","pnca_p.his57arg","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57R","L2","PZA","H","H57",57,"R",1,"XDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",4.561,-0.281,-1.171,1.25273,-0.843,-0.28,76,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0018686215322696,254.917127071823,3820001.12562827,Inf,120.509921037495,-20,-28,0,0,-28,0,0,0,0,2,0,0,2,0,0,0,0,0,0,-2,3,0,0,-2,0,-0.0711752786220871,-0.302583979328165,0.0456271534611995,-0.143734015345269,-0.0732984293193717,0.8,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",15.1557612752498,0.885234541058947,105.0027715034,0.144336773765625,15316.7789338948,20462689243807308,2.40639901531589,1.01650823124183e-20,19.9928891002838,32.1173872780919,Inf,4.89215110948636e-28,"lineage2","dr_mutations_pyrazinamide","ARG",0,"ERR2516288","ERR2516288","lineage2.2.1","be","Belgium","pnca_p.his57arg","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57R","L2","PZA","H","H57",57,"R",1,"XDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",4.561,-0.281,-1.171,1.25273,-0.843,-0.28,76,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0018686215322696,254.917127071823,3820001.12562827,Inf,120.509921037495,-20,-28,0,0,-28,0,0,0,0,2,0,0,2,0,0,0,0,0,0,-2,3,0,0,-2,0,-0.0711752786220871,-0.302583979328165,0.0456271534611995,-0.143734015345269,-0.0732984293193717,0.8,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",15.1557612752498,0.885234541058947,105.0027715034,0.144336773765625,15316.7789338948,20462689243807308,2.40639901531589,1.01650823124183e-20,19.9928891002838,32.1173872780919,Inf,4.89215110948636e-28,"lineage2","dr_mutations_pyrazinamide","ARG",0,"ERR2516264","ERR2516264","lineage2.2.1","be","Belgium","pnca_p.his57arg","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57R","L2","PZA","H","H57",57,"R",1,"XDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",4.561,-0.281,-1.171,1.25273,-0.843,-0.28,76,85,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0018686215322696,254.917127071823,3820001.12562827,Inf,120.509921037495,-20,-28,0,0,-28,0,0,0,0,2,0,0,2,0,0,0,0,0,0,-2,3,0,0,-2,0,-0.0711752786220871,-0.302583979328165,0.0456271534611995,-0.143734015345269,-0.0732984293193717,0.8,-0.969522240527183,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",15.1557612752498,0.885234541058947,105.0027715034,0.144336773765625,15316.7789338948,20462689243807308,2.40639901531589,1.01650823124183e-20,19.9928891002838,32.1173872780919,Inf,4.89215110948636e-28,"lineage2","dr_mutations_pyrazinamide","ARG",0,"SAMN07659960","SRR6046530","lineage2.2.1","gb","UK","pnca_p.his57arg","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57Y","L2","PZA","H","H57",57,"Y",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","basic","neutral","pos","polar",4.561,-1.155,0.405,-0.147464,-0.488,0.9,63,80,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0002156101768003,29.1287878787879,511969.848428296,Inf,9.2872640727157,-10,-6,0,0,-6,0,0,0,0,0,0,0,0,0,0,0,0,-4,0,-2,0,0,0,0,0,-0.292553191489362,0.344387755102041,-0.028351918787972,-0.0832054560954817,0.50561797752809,0.663157894736842,-0.969522240527183,"Destabilising","Stabilising","Stabilising","Destabilising","Stabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",13.1460210124991,0.907969111549563,113.719344731871,0.115600569485296,0.183926936278874,NA,1.4643224129316,0.0049931328456149,2.3016268790981,2.00455510251839,Inf,0.0023075254069185,"lineage2","dr_mutations_pyrazinamide","TYR",0,"SRR6280334","SRR6280334","lineage2.2.1.1","cn","China","pnca_p.his57tyr","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57Y","L4","PZA","H","H57",57,"Y",NA,"MDR","DM","hydrophobic","hydrophobic","basic","neutral","pos","polar",4.561,-1.155,0.405,-0.147464,-0.488,0.9,63,80,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0002156101768003,29.1287878787879,511969.848428296,Inf,9.2872640727157,-10,-6,0,0,-6,0,0,0,0,0,0,0,0,0,0,0,0,-4,0,-2,0,0,0,0,0,-0.292553191489362,0.344387755102041,-0.028351918787972,-0.0832054560954817,0.50561797752809,0.663157894736842,-0.969522240527183,"Destabilising","Stabilising","Stabilising","Destabilising","Stabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",13.1460210124991,0.907969111549563,113.719344731871,0.115600569485296,0.183926936278874,NA,1.4643224129316,0.0049931328456149,2.3016268790981,2.00455510251839,Inf,0.0023075254069185,"lineage4","dr_mutations_pyrazinamide","TYR",0,"ERR3148185","ERR3148185","lineage4.1.2.1","mx","Mexico","pnca_p.his57tyr","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57Y","L2","PZA","H","H57",57,"Y",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","basic","neutral","pos","polar",4.561,-1.155,0.405,-0.147464,-0.488,0.9,63,80,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0002156101768003,29.1287878787879,511969.848428296,Inf,9.2872640727157,-10,-6,0,0,-6,0,0,0,0,0,0,0,0,0,0,0,0,-4,0,-2,0,0,0,0,0,-0.292553191489362,0.344387755102041,-0.028351918787972,-0.0832054560954817,0.50561797752809,0.663157894736842,-0.969522240527183,"Destabilising","Stabilising","Stabilising","Destabilising","Stabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",13.1460210124991,0.907969111549563,113.719344731871,0.115600569485296,0.183926936278874,NA,1.4643224129316,0.0049931328456149,2.3016268790981,2.00455510251839,Inf,0.0023075254069185,"lineage2","dr_mutations_pyrazinamide","TYR",0,"SRR6280207","SRR6280207","lineage2.2.1.1","cn","China","pnca_p.his57tyr","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57Y","L4","PZA","H","H57",57,"Y",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","basic","neutral","pos","polar",4.561,-1.155,0.405,-0.147464,-0.488,0.9,63,80,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0002156101768003,29.1287878787879,511969.848428296,Inf,9.2872640727157,-10,-6,0,0,-6,0,0,0,0,0,0,0,0,0,0,0,0,-4,0,-2,0,0,0,0,0,-0.292553191489362,0.344387755102041,-0.028351918787972,-0.0832054560954817,0.50561797752809,0.663157894736842,-0.969522240527183,"Destabilising","Stabilising","Stabilising","Destabilising","Stabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",13.1460210124991,0.907969111549563,113.719344731871,0.115600569485296,0.183926936278874,NA,1.4643224129316,0.0049931328456149,2.3016268790981,2.00455510251839,Inf,0.0023075254069185,"lineage4","dr_mutations_pyrazinamide","TYR",0,"ERR2515405","ERR2515405","lineage4.3.2.1","za","South Africa","pnca_p.his57tyr","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57Y","L4","PZA","H","H57",57,"Y",NA,"MDR","DM","hydrophobic","hydrophobic","basic","neutral","pos","polar",4.561,-1.155,0.405,-0.147464,-0.488,0.9,63,80,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0002156101768003,29.1287878787879,511969.848428296,Inf,9.2872640727157,-10,-6,0,0,-6,0,0,0,0,0,0,0,0,0,0,0,0,-4,0,-2,0,0,0,0,0,-0.292553191489362,0.344387755102041,-0.028351918787972,-0.0832054560954817,0.50561797752809,0.663157894736842,-0.969522240527183,"Destabilising","Stabilising","Stabilising","Destabilising","Stabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",13.1460210124991,0.907969111549563,113.719344731871,0.115600569485296,0.183926936278874,NA,1.4643224129316,0.0049931328456149,2.3016268790981,2.00455510251839,Inf,0.0023075254069185,"lineage4","dr_mutations_pyrazinamide","TYR",0,"ERR751596","ERR751596","lineage4.3.2","pe","","pnca_p.his57tyr","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57Y","L4","PZA","H","H57",57,"Y",1,"MDR","DM","hydrophobic","hydrophobic","basic","neutral","pos","polar",4.561,-1.155,0.405,-0.147464,-0.488,0.9,63,80,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0002156101768003,29.1287878787879,511969.848428296,Inf,9.2872640727157,-10,-6,0,0,-6,0,0,0,0,0,0,0,0,0,0,0,0,-4,0,-2,0,0,0,0,0,-0.292553191489362,0.344387755102041,-0.028351918787972,-0.0832054560954817,0.50561797752809,0.663157894736842,-0.969522240527183,"Destabilising","Stabilising","Stabilising","Destabilising","Stabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",13.1460210124991,0.907969111549563,113.719344731871,0.115600569485296,0.183926936278874,NA,1.4643224129316,0.0049931328456149,2.3016268790981,2.00455510251839,Inf,0.0023075254069185,"lineage4","dr_mutations_pyrazinamide","TYR",0,"ERR2516347","ERR2516347","lineage4.2.1","be","Belgium","pnca_p.his57tyr","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57Y","L4","PZA","H","H57",57,"Y",1,"XDR","DM","hydrophobic","hydrophobic","basic","neutral","pos","polar",4.561,-1.155,0.405,-0.147464,-0.488,0.9,63,80,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0002156101768003,29.1287878787879,511969.848428296,Inf,9.2872640727157,-10,-6,0,0,-6,0,0,0,0,0,0,0,0,0,0,0,0,-4,0,-2,0,0,0,0,0,-0.292553191489362,0.344387755102041,-0.028351918787972,-0.0832054560954817,0.50561797752809,0.663157894736842,-0.969522240527183,"Destabilising","Stabilising","Stabilising","Destabilising","Stabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",13.1460210124991,0.907969111549563,113.719344731871,0.115600569485296,0.183926936278874,NA,1.4643224129316,0.0049931328456149,2.3016268790981,2.00455510251839,Inf,0.0023075254069185,"lineage4","dr_mutations_pyrazinamide","TYR",0,"ERR1034999","ERR1034999","lineage4.7","za","South Africa","pnca_p.his57tyr","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57Y","L4","PZA","H","H57",57,"Y",NA,"MDR","DM","hydrophobic","hydrophobic","basic","neutral","pos","polar",4.561,-1.155,0.405,-0.147464,-0.488,0.9,63,80,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0002156101768003,29.1287878787879,511969.848428296,Inf,9.2872640727157,-10,-6,0,0,-6,0,0,0,0,0,0,0,0,0,0,0,0,-4,0,-2,0,0,0,0,0,-0.292553191489362,0.344387755102041,-0.028351918787972,-0.0832054560954817,0.50561797752809,0.663157894736842,-0.969522240527183,"Destabilising","Stabilising","Stabilising","Destabilising","Stabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",13.1460210124991,0.907969111549563,113.719344731871,0.115600569485296,0.183926936278874,NA,1.4643224129316,0.0049931328456149,2.3016268790981,2.00455510251839,Inf,0.0023075254069185,"lineage4","dr_mutations_pyrazinamide","TYR",0,"SRR7517793","SRR7517793","lineage4.1","ci","Ivory_Coast","pnca_p.his57tyr","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57Y","L3","PZA","H","H57",57,"Y",1,"XDR","DM","hydrophobic","hydrophobic","basic","neutral","pos","polar",4.561,-1.155,0.405,-0.147464,-0.488,0.9,63,80,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0002156101768003,29.1287878787879,511969.848428296,Inf,9.2872640727157,-10,-6,0,0,-6,0,0,0,0,0,0,0,0,0,0,0,0,-4,0,-2,0,0,0,0,0,-0.292553191489362,0.344387755102041,-0.028351918787972,-0.0832054560954817,0.50561797752809,0.663157894736842,-0.969522240527183,"Destabilising","Stabilising","Stabilising","Destabilising","Stabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",13.1460210124991,0.907969111549563,113.719344731871,0.115600569485296,0.183926936278874,NA,1.4643224129316,0.0049931328456149,2.3016268790981,2.00455510251839,Inf,0.0023075254069185,"lineage3","dr_mutations_pyrazinamide","TYR",0,"ERR3335801","ERR3335801","lineage3","pk","Pakistan","pnca_p.his57tyr","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"H57Y","L2","PZA","H","H57",57,"Y",NA,"MDR","DM","hydrophobic","hydrophobic","basic","neutral","pos","polar",4.561,-1.155,0.405,-0.147464,-0.488,0.9,63,80,-1.177,9,9,16,0.0714285714285714,"helix",-1.3,5.63,0.0002156101768003,29.1287878787879,511969.848428296,Inf,9.2872640727157,-10,-6,0,0,-6,0,0,0,0,0,0,0,0,0,0,0,0,-4,0,-2,0,0,0,0,0,-0.292553191489362,0.344387755102041,-0.028351918787972,-0.0832054560954817,0.50561797752809,0.663157894736842,-0.969522240527183,"Destabilising","Stabilising","Stabilising","Destabilising","Stabilising","effect",-1.221,-1.152,"9:9","148/150","H:S",13.1460210124991,0.907969111549563,113.719344731871,0.115600569485296,0.183926936278874,NA,1.4643224129316,0.0049931328456149,2.3016268790981,2.00455510251839,Inf,0.0023075254069185,"lineage2","dr_mutations_pyrazinamide","TYR",0,"SRS797269","SRR1723795","lineage2.2.1","cn","China:Jiangsu","pnca_p.his57tyr","A","G","HIS","HA57","pnca_complex.pdb"
|
|
"F58L","L2","PZA","F","F58",58,"L",0,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",8.072,-2.337,-1.639,0.155134,-0.746,-1.43,74,85,-1.108,9,9,43,0.179166666666667,"strand",-0.4,4.41,0.000646830530401,6.07150379106992,6.0715037407715,6.07036843596735,6.87801392972404,10,2,0,0,2,0,0,0,0,0,0,0,0,0,0,0,0,-3,0,-3,1,2,0,6,0,-0.591945288753799,-0.423514211886305,0.0056503179656029,-0.127195225916454,-0.37434554973822,0.778947368421053,-0.912685337726524,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.178,-1.062,"9:9","148/150","W:I:F",1.80360630763137,0.0072061894224301,0.671193623356544,2.68716245933892,1.60530087074952,24.5460966015953,0.783296270528047,0.0099794518593429,2.00089331252028,1.30550120941319,30.6177596174465,0.0087262477054536,"lineage2","dr_mutations_pyrazinamide","LEU",0,"ERR133844,0311P-sc-2012-02-09T18:55:55Z-1355177","ERR133844","lineage2.2.1","ru","Russia,Samara","pnca_p.phe58leu","A","B","PHE","FA58","pnca_complex.pdb"
|
|
"F58L","L4","PZA","F","F58",58,"L",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",8.072,-2.337,-1.639,0.155134,-0.746,-1.43,74,85,-1.108,9,9,43,0.179166666666667,"strand",-0.4,4.41,0.000646830530401,6.07150379106992,6.0715037407715,6.07036843596735,6.87801392972404,10,2,0,0,2,0,0,0,0,0,0,0,0,0,0,0,0,-3,0,-3,1,2,0,6,0,-0.591945288753799,-0.423514211886305,0.0056503179656029,-0.127195225916454,-0.37434554973822,0.778947368421053,-0.912685337726524,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.178,-1.062,"9:9","148/150","W:I:F",1.80360630763137,0.0072061894224301,0.671193623356544,2.68716245933892,1.60530087074952,24.5460966015953,0.783296270528047,0.0099794518593429,2.00089331252028,1.30550120941319,30.6177596174465,0.0087262477054536,"lineage4","dr_mutations_pyrazinamide","LEU",0,"ERR2446468","ERR2446468","lineage4.2.2","nl","Netherlands","pnca_p.phe58leu","A","B","PHE","FA58","pnca_complex.pdb"
|
|
"F58L","L4","PZA","F","F58",58,"L",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",8.072,-2.337,-1.639,0.155134,-0.746,-1.43,74,85,-1.108,9,9,43,0.179166666666667,"strand",-0.4,4.41,0.000646830530401,6.07150379106992,6.0715037407715,6.07036843596735,6.87801392972404,10,2,0,0,2,0,0,0,0,0,0,0,0,0,0,0,0,-3,0,-3,1,2,0,6,0,-0.591945288753799,-0.423514211886305,0.0056503179656029,-0.127195225916454,-0.37434554973822,0.778947368421053,-0.912685337726524,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.178,-1.062,"9:9","148/150","W:I:F",1.80360630763137,0.0072061894224301,0.671193623356544,2.68716245933892,1.60530087074952,24.5460966015953,0.783296270528047,0.0099794518593429,2.00089331252028,1.30550120941319,30.6177596174465,0.0087262477054536,"lineage4","dr_mutations_pyrazinamide","LEU",0,"ERR751476","ERR751476","lineage4.3.4.2","pe","","pnca_p.phe58leu","A","B","PHE","FA58","pnca_complex.pdb"
|
|
"F58L","L2","PZA","F","F58",58,"L",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",8.072,-2.337,-1.639,0.155134,-0.746,-1.43,74,85,-1.108,9,9,43,0.179166666666667,"strand",-0.4,4.41,0.000646830530401,6.07150379106992,6.0715037407715,6.07036843596735,6.87801392972404,10,2,0,0,2,0,0,0,0,0,0,0,0,0,0,0,0,-3,0,-3,1,2,0,6,0,-0.591945288753799,-0.423514211886305,0.0056503179656029,-0.127195225916454,-0.37434554973822,0.778947368421053,-0.912685337726524,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.178,-1.062,"9:9","148/150","W:I:F",1.80360630763137,0.0072061894224301,0.671193623356544,2.68716245933892,1.60530087074952,24.5460966015953,0.783296270528047,0.0099794518593429,2.00089331252028,1.30550120941319,30.6177596174465,0.0087262477054536,"lineage2","dr_mutations_pyrazinamide","LEU",0,"SAMN02360603","SRR1013649_SRR1049045_SRR1013648_SRR1049044","lineage2.2.2","kr","South Korea","pnca_p.phe58leu","A","B","PHE","FA58","pnca_complex.pdb"
|
|
"F58L","L2","PZA","F","F58",58,"L",1,"MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",8.072,-2.337,-1.639,0.155134,-0.746,-1.43,74,85,-1.108,9,9,43,0.179166666666667,"strand",-0.4,4.41,0.000646830530401,6.07150379106992,6.0715037407715,6.07036843596735,6.87801392972404,10,2,0,0,2,0,0,0,0,0,0,0,0,0,0,0,0,-3,0,-3,1,2,0,6,0,-0.591945288753799,-0.423514211886305,0.0056503179656029,-0.127195225916454,-0.37434554973822,0.778947368421053,-0.912685337726524,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.178,-1.062,"9:9","148/150","W:I:F",1.80360630763137,0.0072061894224301,0.671193623356544,2.68716245933892,1.60530087074952,24.5460966015953,0.783296270528047,0.0099794518593429,2.00089331252028,1.30550120941319,30.6177596174465,0.0087262477054536,"lineage2","dr_mutations_pyrazinamide","LEU",0,"SAMN02053752","SRR833061_SRR833096","lineage2.2.1","za","South Africa","pnca_p.phe58leu","A","B","PHE","FA58","pnca_complex.pdb"
|
|
"F58L","L4","PZA","F","F58",58,"L",0,"MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",8.072,-2.337,-1.639,0.155134,-0.746,-1.43,74,85,-1.108,9,9,43,0.179166666666667,"strand",-0.4,4.41,0.000646830530401,6.07150379106992,6.0715037407715,6.07036843596735,6.87801392972404,10,2,0,0,2,0,0,0,0,0,0,0,0,0,0,0,0,-3,0,-3,1,2,0,6,0,-0.591945288753799,-0.423514211886305,0.0056503179656029,-0.127195225916454,-0.37434554973822,0.778947368421053,-0.912685337726524,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.178,-1.062,"9:9","148/150","W:I:F",1.80360630763137,0.0072061894224301,0.671193623356544,2.68716245933892,1.60530087074952,24.5460966015953,0.783296270528047,0.0099794518593429,2.00089331252028,1.30550120941319,30.6177596174465,0.0087262477054536,"lineage4","dr_mutations_pyrazinamide","LEU",0,"ERR2517379","ERR2517379","lineage4.2.2","nl","Netherlands","pnca_p.phe58leu","A","B","PHE","FA58","pnca_complex.pdb"
|
|
"F58L","L1","PZA","F","F58",58,"L",0,"MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",8.072,-2.337,-1.639,0.155134,-0.746,-1.43,74,85,-1.108,9,9,43,0.179166666666667,"strand",-0.4,4.41,0.000646830530401,6.07150379106992,6.0715037407715,6.07036843596735,6.87801392972404,10,2,0,0,2,0,0,0,0,0,0,0,0,0,0,0,0,-3,0,-3,1,2,0,6,0,-0.591945288753799,-0.423514211886305,0.0056503179656029,-0.127195225916454,-0.37434554973822,0.778947368421053,-0.912685337726524,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.178,-1.062,"9:9","148/150","W:I:F",1.80360630763137,0.0072061894224301,0.671193623356544,2.68716245933892,1.60530087074952,24.5460966015953,0.783296270528047,0.0099794518593429,2.00089331252028,1.30550120941319,30.6177596174465,0.0087262477054536,"lineage1","dr_mutations_pyrazinamide","LEU",0,"ERR2510266","ERR2510266","lineage1.1.2","pk","Pakistan","pnca_p.phe58leu","A","B","PHE","FA58","pnca_complex.pdb"
|
|
"F58L","L4","PZA","F","F58",58,"L",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",8.072,-2.337,-1.639,0.155134,-0.746,-1.43,74,85,-1.108,9,9,43,0.179166666666667,"strand",-0.4,4.41,0.000646830530401,6.07150379106992,6.0715037407715,6.07036843596735,6.87801392972404,10,2,0,0,2,0,0,0,0,0,0,0,0,0,0,0,0,-3,0,-3,1,2,0,6,0,-0.591945288753799,-0.423514211886305,0.0056503179656029,-0.127195225916454,-0.37434554973822,0.778947368421053,-0.912685337726524,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.178,-1.062,"9:9","148/150","W:I:F",1.80360630763137,0.0072061894224301,0.671193623356544,2.68716245933892,1.60530087074952,24.5460966015953,0.783296270528047,0.0099794518593429,2.00089331252028,1.30550120941319,30.6177596174465,0.0087262477054536,"lineage4","dr_mutations_pyrazinamide","LEU",0,"ERR3275727","ERR3275727","lineage4.2.2","nl","Netherlands","pnca_p.phe58leu","A","B","PHE","FA58","pnca_complex.pdb"
|
|
"F58L","L4","PZA","F","F58",58,"L",1,"MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",8.072,-2.337,-1.639,0.155134,-0.746,-1.43,74,85,-1.108,9,9,43,0.179166666666667,"strand",-0.4,4.41,0.000646830530401,6.07150379106992,6.0715037407715,6.07036843596735,6.87801392972404,10,2,0,0,2,0,0,0,0,0,0,0,0,0,0,0,0,-3,0,-3,1,2,0,6,0,-0.591945288753799,-0.423514211886305,0.0056503179656029,-0.127195225916454,-0.37434554973822,0.778947368421053,-0.912685337726524,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.178,-1.062,"9:9","148/150","W:I:F",1.80360630763137,0.0072061894224301,0.671193623356544,2.68716245933892,1.60530087074952,24.5460966015953,0.783296270528047,0.0099794518593429,2.00089331252028,1.30550120941319,30.6177596174465,0.0087262477054536,"lineage4","dr_mutations_pyrazinamide","LEU",0,"ERR2516731","ERR2516731","lineage4.3.4.2","pe","Peru","pnca_p.phe58leu","A","B","PHE","FA58","pnca_complex.pdb"
|
|
"F58L","L2","PZA","F","F58",58,"L",1,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",8.072,-2.337,-1.639,0.155134,-0.746,-1.43,74,85,-1.108,9,9,43,0.179166666666667,"strand",-0.4,4.41,0.000646830530401,6.07150379106992,6.0715037407715,6.07036843596735,6.87801392972404,10,2,0,0,2,0,0,0,0,0,0,0,0,0,0,0,0,-3,0,-3,1,2,0,6,0,-0.591945288753799,-0.423514211886305,0.0056503179656029,-0.127195225916454,-0.37434554973822,0.778947368421053,-0.912685337726524,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.178,-1.062,"9:9","148/150","W:I:F",1.80360630763137,0.0072061894224301,0.671193623356544,2.68716245933892,1.60530087074952,24.5460966015953,0.783296270528047,0.0099794518593429,2.00089331252028,1.30550120941319,30.6177596174465,0.0087262477054536,"lineage2","dr_mutations_pyrazinamide","LEU",0,"ETB0157","SRR6257056","lineage2.2.1","ru","Russia:Dagestan","pnca_p.phe58leu","A","B","PHE","FA58","pnca_complex.pdb"
|
|
"F58L","L4","PZA","F","F58",58,"L",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",8.072,-2.337,-1.639,0.155134,-0.746,-1.43,74,85,-1.108,9,9,43,0.179166666666667,"strand",-0.4,4.41,0.000646830530401,6.07150379106992,6.0715037407715,6.07036843596735,6.87801392972404,10,2,0,0,2,0,0,0,0,0,0,0,0,0,0,0,0,-3,0,-3,1,2,0,6,0,-0.591945288753799,-0.423514211886305,0.0056503179656029,-0.127195225916454,-0.37434554973822,0.778947368421053,-0.912685337726524,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.178,-1.062,"9:9","148/150","W:I:F",1.80360630763137,0.0072061894224301,0.671193623356544,2.68716245933892,1.60530087074952,24.5460966015953,0.783296270528047,0.0099794518593429,2.00089331252028,1.30550120941319,30.6177596174465,0.0087262477054536,"lineage4","dr_mutations_pyrazinamide","LEU",0,"ERR3275716","ERR3275716","lineage4.2.2","nl","Netherlands","pnca_p.phe58leu","A","B","PHE","FA58","pnca_complex.pdb"
|
|
"F58L","L4","PZA","F","F58",58,"L",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",8.072,-2.337,-1.639,0.155134,-0.746,-1.43,74,85,-1.108,9,9,43,0.179166666666667,"strand",-0.4,4.41,0.000646830530401,6.07150379106992,6.0715037407715,6.07036843596735,6.87801392972404,10,2,0,0,2,0,0,0,0,0,0,0,0,0,0,0,0,-3,0,-3,1,2,0,6,0,-0.591945288753799,-0.423514211886305,0.0056503179656029,-0.127195225916454,-0.37434554973822,0.778947368421053,-0.912685337726524,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.178,-1.062,"9:9","148/150","W:I:F",1.80360630763137,0.0072061894224301,0.671193623356544,2.68716245933892,1.60530087074952,24.5460966015953,0.783296270528047,0.0099794518593429,2.00089331252028,1.30550120941319,30.6177596174465,0.0087262477054536,"lineage4","dr_mutations_pyrazinamide","LEU",0,"SRR5818580","SRR5818580","lineage4.2.2.1","dj","Djibouti","pnca_p.phe58leu","A","B","PHE","FA58","pnca_complex.pdb"
|
|
"F58L","L4","PZA","F","F58",58,"L",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",8.072,-2.337,-1.639,0.155134,-0.746,-1.43,74,85,-1.108,9,9,43,0.179166666666667,"strand",-0.4,4.41,0.000646830530401,6.07150379106992,6.0715037407715,6.07036843596735,6.87801392972404,10,2,0,0,2,0,0,0,0,0,0,0,0,0,0,0,0,-3,0,-3,1,2,0,6,0,-0.591945288753799,-0.423514211886305,0.0056503179656029,-0.127195225916454,-0.37434554973822,0.778947368421053,-0.912685337726524,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.178,-1.062,"9:9","148/150","W:I:F",1.80360630763137,0.0072061894224301,0.671193623356544,2.68716245933892,1.60530087074952,24.5460966015953,0.783296270528047,0.0099794518593429,2.00089331252028,1.30550120941319,30.6177596174465,0.0087262477054536,"lineage4","dr_mutations_pyrazinamide","LEU",0,"SAMN02414874","SRR1146293_SRR1144760_SRR1162986_SRR1162874","lineage4.2.2","se","Sweden","pnca_p.phe58leu","A","B","PHE","FA58","pnca_complex.pdb"
|
|
"F58L","L4","PZA","F","F58",58,"L",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",8.072,-2.337,-1.639,0.155134,-0.746,-1.43,74,85,-1.108,9,9,43,0.179166666666667,"strand",-0.4,4.41,0.000646830530401,6.07150379106992,6.0715037407715,6.07036843596735,6.87801392972404,10,2,0,0,2,0,0,0,0,0,0,0,0,0,0,0,0,-3,0,-3,1,2,0,6,0,-0.591945288753799,-0.423514211886305,0.0056503179656029,-0.127195225916454,-0.37434554973822,0.778947368421053,-0.912685337726524,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.178,-1.062,"9:9","148/150","W:I:F",1.80360630763137,0.0072061894224301,0.671193623356544,2.68716245933892,1.60530087074952,24.5460966015953,0.783296270528047,0.0099794518593429,2.00089331252028,1.30550120941319,30.6177596174465,0.0087262477054536,"lineage4","dr_mutations_pyrazinamide","LEU",0,"SAMN02414930","SRR1166925_SRR1144784_SRR1162796_SRR1146330","lineage4.2.2","se","Sweden","pnca_p.phe58leu","A","B","PHE","FA58","pnca_complex.pdb"
|
|
"F58L","L4","PZA","F","F58",58,"L",1,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",8.072,-2.337,-1.639,0.155134,-0.746,-1.43,74,85,-1.108,9,9,43,0.179166666666667,"strand",-0.4,4.41,0.000646830530401,6.07150379106992,6.0715037407715,6.07036843596735,6.87801392972404,10,2,0,0,2,0,0,0,0,0,0,0,0,0,0,0,0,-3,0,-3,1,2,0,6,0,-0.591945288753799,-0.423514211886305,0.0056503179656029,-0.127195225916454,-0.37434554973822,0.778947368421053,-0.912685337726524,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.178,-1.062,"9:9","148/150","W:I:F",1.80360630763137,0.0072061894224301,0.671193623356544,2.68716245933892,1.60530087074952,24.5460966015953,0.783296270528047,0.0099794518593429,2.00089331252028,1.30550120941319,30.6177596174465,0.0087262477054536,"lineage4","dr_mutations_pyrazinamide","LEU",0,"ERR2516491","ERR2516491","lineage4.3.4.2","pe","Peru","pnca_p.phe58leu","A","B","PHE","FA58","pnca_complex.pdb"
|
|
"F58L","L4","PZA","F","F58",58,"L",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",8.072,-2.337,-1.639,0.155134,-0.746,-1.43,74,85,-1.108,9,9,43,0.179166666666667,"strand",-0.4,4.41,0.000646830530401,6.07150379106992,6.0715037407715,6.07036843596735,6.87801392972404,10,2,0,0,2,0,0,0,0,0,0,0,0,0,0,0,0,-3,0,-3,1,2,0,6,0,-0.591945288753799,-0.423514211886305,0.0056503179656029,-0.127195225916454,-0.37434554973822,0.778947368421053,-0.912685337726524,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.178,-1.062,"9:9","148/150","W:I:F",1.80360630763137,0.0072061894224301,0.671193623356544,2.68716245933892,1.60530087074952,24.5460966015953,0.783296270528047,0.0099794518593429,2.00089331252028,1.30550120941319,30.6177596174465,0.0087262477054536,"lineage4","dr_mutations_pyrazinamide","LEU",0,"ERR3275385","ERR3275385","lineage4.2.2","nl","Netherlands","pnca_p.phe58leu","A","B","PHE","FA58","pnca_complex.pdb"
|
|
"F58L","L2","PZA","F","F58",58,"L",0,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",8.072,-2.337,-1.639,0.155134,-0.746,-1.43,74,85,-1.108,9,9,43,0.179166666666667,"strand",-0.4,4.41,0.000646830530401,6.07150379106992,6.0715037407715,6.07036843596735,6.87801392972404,10,2,0,0,2,0,0,0,0,0,0,0,0,0,0,0,0,-3,0,-3,1,2,0,6,0,-0.591945288753799,-0.423514211886305,0.0056503179656029,-0.127195225916454,-0.37434554973822,0.778947368421053,-0.912685337726524,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.178,-1.062,"9:9","148/150","W:I:F",1.80360630763137,0.0072061894224301,0.671193623356544,2.68716245933892,1.60530087074952,24.5460966015953,0.783296270528047,0.0099794518593429,2.00089331252028,1.30550120941319,30.6177596174465,0.0087262477054536,"lineage2","dr_mutations_pyrazinamide","LEU",0,"ERR027446","ERR027446","lineage2.2.1","ru","Russia","pnca_p.phe58leu","A","B","PHE","FA58","pnca_complex.pdb"
|
|
"F58L","L4","PZA","F","F58",58,"L",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",8.072,-2.337,-1.639,0.155134,-0.746,-1.43,74,85,-1.108,9,9,43,0.179166666666667,"strand",-0.4,4.41,0.000646830530401,6.07150379106992,6.0715037407715,6.07036843596735,6.87801392972404,10,2,0,0,2,0,0,0,0,0,0,0,0,0,0,0,0,-3,0,-3,1,2,0,6,0,-0.591945288753799,-0.423514211886305,0.0056503179656029,-0.127195225916454,-0.37434554973822,0.778947368421053,-0.912685337726524,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.178,-1.062,"9:9","148/150","W:I:F",1.80360630763137,0.0072061894224301,0.671193623356544,2.68716245933892,1.60530087074952,24.5460966015953,0.783296270528047,0.0099794518593429,2.00089331252028,1.30550120941319,30.6177596174465,0.0087262477054536,"lineage4","dr_mutations_pyrazinamide","LEU",0,"ERR1023412","ERR1023412","lineage4.2.2","","","pnca_p.phe58leu","A","B","PHE","FA58","pnca_complex.pdb"
|
|
"F58L","L4","PZA","F","F58",58,"L",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",8.072,-2.337,-1.639,0.155134,-0.746,-1.43,74,85,-1.108,9,9,43,0.179166666666667,"strand",-0.4,4.41,0.000646830530401,6.07150379106992,6.0715037407715,6.07036843596735,6.87801392972404,10,2,0,0,2,0,0,0,0,0,0,0,0,0,0,0,0,-3,0,-3,1,2,0,6,0,-0.591945288753799,-0.423514211886305,0.0056503179656029,-0.127195225916454,-0.37434554973822,0.778947368421053,-0.912685337726524,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.178,-1.062,"9:9","148/150","W:I:F",1.80360630763137,0.0072061894224301,0.671193623356544,2.68716245933892,1.60530087074952,24.5460966015953,0.783296270528047,0.0099794518593429,2.00089331252028,1.30550120941319,30.6177596174465,0.0087262477054536,"lineage4","dr_mutations_pyrazinamide","LEU",0,"SAMN02414896","SRR1144814_SRR1163128_SRR1146329_SRR1163014","lineage4.2.2","se","Sweden","pnca_p.phe58leu","A","B","PHE","FA58","pnca_complex.pdb"
|
|
"F58L","L4","PZA","F","F58",58,"L",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",8.072,-2.337,-1.639,0.155134,-0.746,-1.43,74,85,-1.108,9,9,43,0.179166666666667,"strand",-0.4,4.41,0.000646830530401,6.07150379106992,6.0715037407715,6.07036843596735,6.87801392972404,10,2,0,0,2,0,0,0,0,0,0,0,0,0,0,0,0,-3,0,-3,1,2,0,6,0,-0.591945288753799,-0.423514211886305,0.0056503179656029,-0.127195225916454,-0.37434554973822,0.778947368421053,-0.912685337726524,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.178,-1.062,"9:9","148/150","W:I:F",1.80360630763137,0.0072061894224301,0.671193623356544,2.68716245933892,1.60530087074952,24.5460966015953,0.783296270528047,0.0099794518593429,2.00089331252028,1.30550120941319,30.6177596174465,0.0087262477054536,"lineage4","dr_mutations_pyrazinamide","LEU",0,"SAMN02414887","SRR1146301_SRR1163179_SRR1144785_SRR1163093","lineage4.2.2","se","Sweden","pnca_p.phe58leu","A","B","PHE","FA58","pnca_complex.pdb"
|
|
"F58L","L2","PZA","F","F58",58,"L",NA,"XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",8.072,-2.337,-1.639,0.155134,-0.746,-1.43,74,85,-1.108,9,9,43,0.179166666666667,"strand",-0.4,4.41,0.000646830530401,6.07150379106992,6.0715037407715,6.07036843596735,6.87801392972404,10,2,0,0,2,0,0,0,0,0,0,0,0,0,0,0,0,-3,0,-3,1,2,0,6,0,-0.591945288753799,-0.423514211886305,0.0056503179656029,-0.127195225916454,-0.37434554973822,0.778947368421053,-0.912685337726524,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.178,-1.062,"9:9","148/150","W:I:F",1.80360630763137,0.0072061894224301,0.671193623356544,2.68716245933892,1.60530087074952,24.5460966015953,0.783296270528047,0.0099794518593429,2.00089331252028,1.30550120941319,30.6177596174465,0.0087262477054536,"lineage2","dr_mutations_pyrazinamide","LEU",0,"BGI_LN130,SRR671794","SRR671794","lineage2.2.1","cn","China","pnca_p.phe58leu","A","B","PHE","FA58","pnca_complex.pdb"
|
|
"F58L","L4","PZA","F","F58",58,"L",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",8.072,-2.337,-1.639,0.155134,-0.746,-1.43,74,85,-1.108,9,9,43,0.179166666666667,"strand",-0.4,4.41,0.000646830530401,6.07150379106992,6.0715037407715,6.07036843596735,6.87801392972404,10,2,0,0,2,0,0,0,0,0,0,0,0,0,0,0,0,-3,0,-3,1,2,0,6,0,-0.591945288753799,-0.423514211886305,0.0056503179656029,-0.127195225916454,-0.37434554973822,0.778947368421053,-0.912685337726524,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.178,-1.062,"9:9","148/150","W:I:F",1.80360630763137,0.0072061894224301,0.671193623356544,2.68716245933892,1.60530087074952,24.5460966015953,0.783296270528047,0.0099794518593429,2.00089331252028,1.30550120941319,30.6177596174465,0.0087262477054536,"lineage4","dr_mutations_pyrazinamide","LEU",0,"SAMN02414876","SRR1163123_SRR1144808_SRR1146309_SRR1162879","lineage4.2.2","se","Sweden","pnca_p.phe58leu","A","B","PHE","FA58","pnca_complex.pdb"
|
|
"F58L","L4","PZA","F","F58",58,"L",1,"MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",8.072,-2.337,-1.639,0.155134,-0.746,-1.43,74,85,-1.108,9,9,43,0.179166666666667,"strand",-0.4,4.41,0.000646830530401,6.07150379106992,6.0715037407715,6.07036843596735,6.87801392972404,10,2,0,0,2,0,0,0,0,0,0,0,0,0,0,0,0,-3,0,-3,1,2,0,6,0,-0.591945288753799,-0.423514211886305,0.0056503179656029,-0.127195225916454,-0.37434554973822,0.778947368421053,-0.912685337726524,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.178,-1.062,"9:9","148/150","W:I:F",1.80360630763137,0.0072061894224301,0.671193623356544,2.68716245933892,1.60530087074952,24.5460966015953,0.783296270528047,0.0099794518593429,2.00089331252028,1.30550120941319,30.6177596174465,0.0087262477054536,"lineage4","dr_mutations_pyrazinamide","LEU",0,"ERR2516497","ERR2516497","lineage4.3.4.2","pe","Peru","pnca_p.phe58leu","A","B","PHE","FA58","pnca_complex.pdb"
|
|
"F58L","L4","PZA","F","F58",58,"L",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",8.072,-2.337,-1.639,0.155134,-0.746,-1.43,74,85,-1.108,9,9,43,0.179166666666667,"strand",-0.4,4.41,0.000646830530401,6.07150379106992,6.0715037407715,6.07036843596735,6.87801392972404,10,2,0,0,2,0,0,0,0,0,0,0,0,0,0,0,0,-3,0,-3,1,2,0,6,0,-0.591945288753799,-0.423514211886305,0.0056503179656029,-0.127195225916454,-0.37434554973822,0.778947368421053,-0.912685337726524,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.178,-1.062,"9:9","148/150","W:I:F",1.80360630763137,0.0072061894224301,0.671193623356544,2.68716245933892,1.60530087074952,24.5460966015953,0.783296270528047,0.0099794518593429,2.00089331252028,1.30550120941319,30.6177596174465,0.0087262477054536,"lineage4","dr_mutations_pyrazinamide","LEU",0,"SAMN02414873","SRR1146289_SRR1162968_SRR1144833_SRR1163085","lineage4.2.2","se","Sweden","pnca_p.phe58leu","A","B","PHE","FA58","pnca_complex.pdb"
|
|
"F58S","L2","PZA","F","F58",58,"S",NA,"MDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",8.072,-0.806,-2.784,2.9435,-1.022,-3,78,85,-1.108,9,9,43,0.179166666666667,"strand",-0.4,4.41,0.0001437401178668,4.85029436501262,4.85029432717734,4.84956447904112,0.0881192621863332,28,2,0,0,2,0,0,0,0,0,0,0,-2,0,0,0,0,0,0,0,2,6,0,10,2,-0.204154002026342,-0.71937984496124,0.107208677219385,-0.174254049445865,-0.785340314136126,0.821052631578947,-0.912685337726524,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.178,-1.062,"9:9","148/150","W:I:F",1.57903938912402,0.264247566376723,1.41439286276584,1.11640791656443,0.191756076673649,122.683760399218,0.685768096792206,0.312734154310187,0.504824686014995,0.061763864579114,379.558337204203,0.766581879696361,"lineage2","dr_mutations_pyrazinamide","SER",0,"SRR5065526","SRR5065526","lineage2.2.1","vn","Vietnam","pnca_p.phe58ser","A","B","PHE","FA58","pnca_complex.pdb"
|
|
"F58S","L2","PZA","F","F58",58,"S",NA,"MDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",8.072,-0.806,-2.784,2.9435,-1.022,-3,78,85,-1.108,9,9,43,0.179166666666667,"strand",-0.4,4.41,0.0001437401178668,4.85029436501262,4.85029432717734,4.84956447904112,0.0881192621863332,28,2,0,0,2,0,0,0,0,0,0,0,-2,0,0,0,0,0,0,0,2,6,0,10,2,-0.204154002026342,-0.71937984496124,0.107208677219385,-0.174254049445865,-0.785340314136126,0.821052631578947,-0.912685337726524,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.178,-1.062,"9:9","148/150","W:I:F",1.57903938912402,0.264247566376723,1.41439286276584,1.11640791656443,0.191756076673649,122.683760399218,0.685768096792206,0.312734154310187,0.504824686014995,0.061763864579114,379.558337204203,0.766581879696361,"lineage2","dr_mutations_pyrazinamide","SER",0,"SRR5065595","SRR5065595","lineage2.2.1","vn","Vietnam","pnca_p.phe58ser","A","B","PHE","FA58","pnca_complex.pdb"
|
|
"F58S","L2","PZA","F","F58",58,"S",NA,"MDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",8.072,-0.806,-2.784,2.9435,-1.022,-3,78,85,-1.108,9,9,43,0.179166666666667,"strand",-0.4,4.41,0.0001437401178668,4.85029436501262,4.85029432717734,4.84956447904112,0.0881192621863332,28,2,0,0,2,0,0,0,0,0,0,0,-2,0,0,0,0,0,0,0,2,6,0,10,2,-0.204154002026342,-0.71937984496124,0.107208677219385,-0.174254049445865,-0.785340314136126,0.821052631578947,-0.912685337726524,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.178,-1.062,"9:9","148/150","W:I:F",1.57903938912402,0.264247566376723,1.41439286276584,1.11640791656443,0.191756076673649,122.683760399218,0.685768096792206,0.312734154310187,0.504824686014995,0.061763864579114,379.558337204203,0.766581879696361,"lineage2","dr_mutations_pyrazinamide","SER",0,"SRS797152","SRR1723663","lineage2.2.1","cn","China:InnerMongolia","pnca_p.phe58ser","A","B","PHE","FA58","pnca_complex.pdb"
|
|
"F58S","L2","PZA","F","F58",58,"S",0,"MDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",8.072,-0.806,-2.784,2.9435,-1.022,-3,78,85,-1.108,9,9,43,0.179166666666667,"strand",-0.4,4.41,0.0001437401178668,4.85029436501262,4.85029432717734,4.84956447904112,0.0881192621863332,28,2,0,0,2,0,0,0,0,0,0,0,-2,0,0,0,0,0,0,0,2,6,0,10,2,-0.204154002026342,-0.71937984496124,0.107208677219385,-0.174254049445865,-0.785340314136126,0.821052631578947,-0.912685337726524,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.178,-1.062,"9:9","148/150","W:I:F",1.57903938912402,0.264247566376723,1.41439286276584,1.11640791656443,0.191756076673649,122.683760399218,0.685768096792206,0.312734154310187,0.504824686014995,0.061763864579114,379.558337204203,0.766581879696361,"lineage2","dr_mutations_pyrazinamide","SER",0,"MDR_5110","SRR6824652","lineage2.2.1","cn","China: Huimin District, Huhhot City, Inner Mongolia Province","pnca_p.phe58ser","A","B","PHE","FA58","pnca_complex.pdb"
|
|
"F58S","L2","PZA","F","F58",58,"S",1,"Pre-XDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",8.072,-0.806,-2.784,2.9435,-1.022,-3,78,85,-1.108,9,9,43,0.179166666666667,"strand",-0.4,4.41,0.0001437401178668,4.85029436501262,4.85029432717734,4.84956447904112,0.0881192621863332,28,2,0,0,2,0,0,0,0,0,0,0,-2,0,0,0,0,0,0,0,2,6,0,10,2,-0.204154002026342,-0.71937984496124,0.107208677219385,-0.174254049445865,-0.785340314136126,0.821052631578947,-0.912685337726524,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.178,-1.062,"9:9","148/150","W:I:F",1.57903938912402,0.264247566376723,1.41439286276584,1.11640791656443,0.191756076673649,122.683760399218,0.685768096792206,0.312734154310187,0.504824686014995,0.061763864579114,379.558337204203,0.766581879696361,"lineage2","dr_mutations_pyrazinamide","SER",0,"ERR1035103","ERR1035103","lineage2.2.1","vn","Vietnam","pnca_p.phe58ser","A","B","PHE","FA58","pnca_complex.pdb"
|
|
"F58S","L3","PZA","F","F58",58,"S",NA,"MDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",8.072,-0.806,-2.784,2.9435,-1.022,-3,78,85,-1.108,9,9,43,0.179166666666667,"strand",-0.4,4.41,0.0001437401178668,4.85029436501262,4.85029432717734,4.84956447904112,0.0881192621863332,28,2,0,0,2,0,0,0,0,0,0,0,-2,0,0,0,0,0,0,0,2,6,0,10,2,-0.204154002026342,-0.71937984496124,0.107208677219385,-0.174254049445865,-0.785340314136126,0.821052631578947,-0.912685337726524,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.178,-1.062,"9:9","148/150","W:I:F",1.57903938912402,0.264247566376723,1.41439286276584,1.11640791656443,0.191756076673649,122.683760399218,0.685768096792206,0.312734154310187,0.504824686014995,0.061763864579114,379.558337204203,0.766581879696361,"lineage3","dr_mutations_pyrazinamide","SER",0,"SAMN02380987","SRR1140692_SRR1049573_SRR1062876_SRR1049574","lineage3.1.2.1","ug","Uganda","pnca_p.phe58ser","A","B","PHE","FA58","pnca_complex.pdb"
|
|
"F58S","L2","PZA","F","F58",58,"S",NA,"MDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",8.072,-0.806,-2.784,2.9435,-1.022,-3,78,85,-1.108,9,9,43,0.179166666666667,"strand",-0.4,4.41,0.0001437401178668,4.85029436501262,4.85029432717734,4.84956447904112,0.0881192621863332,28,2,0,0,2,0,0,0,0,0,0,0,-2,0,0,0,0,0,0,0,2,6,0,10,2,-0.204154002026342,-0.71937984496124,0.107208677219385,-0.174254049445865,-0.785340314136126,0.821052631578947,-0.912685337726524,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.178,-1.062,"9:9","148/150","W:I:F",1.57903938912402,0.264247566376723,1.41439286276584,1.11640791656443,0.191756076673649,122.683760399218,0.685768096792206,0.312734154310187,0.504824686014995,0.061763864579114,379.558337204203,0.766581879696361,"lineage2","dr_mutations_pyrazinamide","SER",0,"SRR5067289","SRR5067289","lineage2.2.1","vn","Vietnam","pnca_p.phe58ser","A","B","PHE","FA58","pnca_complex.pdb"
|
|
"F58S","L4","PZA","F","F58",58,"S",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",8.072,-0.806,-2.784,2.9435,-1.022,-3,78,85,-1.108,9,9,43,0.179166666666667,"strand",-0.4,4.41,0.0001437401178668,4.85029436501262,4.85029432717734,4.84956447904112,0.0881192621863332,28,2,0,0,2,0,0,0,0,0,0,0,-2,0,0,0,0,0,0,0,2,6,0,10,2,-0.204154002026342,-0.71937984496124,0.107208677219385,-0.174254049445865,-0.785340314136126,0.821052631578947,-0.912685337726524,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.178,-1.062,"9:9","148/150","W:I:F",1.57903938912402,0.264247566376723,1.41439286276584,1.11640791656443,0.191756076673649,122.683760399218,0.685768096792206,0.312734154310187,0.504824686014995,0.061763864579114,379.558337204203,0.766581879696361,"lineage4","dr_mutations_pyrazinamide","SER",0,"SAMN02350479","SRR1140936_SRR1019141","lineage4.4.1.1","za","South Africa","pnca_p.phe58ser","A","B","PHE","FA58","pnca_complex.pdb"
|
|
"F58V","L5","PZA","F","F58",58,"V",NA,"MDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",8.072,-2.319,-1.927,1.56433,-1.103,-1.7,71,85,-1.108,9,9,43,0.179166666666667,"strand",-0.4,4.41,7.18700589334483e-05,2.42412778478352,0.0001249735077034,0,1.03410070803344e-29,28,2,0,0,2,0,0,0,0,0,0,2,-2,0,0,0,0,-2,0,-2,2,4,0,8,-2,-0.587386018237082,-0.497932816537468,0.0569763037318162,-0.188064791133845,-0.445026178010471,0.747368421052632,-0.912685337726524,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.178,-1.062,"9:9","148/150","W:I:F",-8.98740878149641,0.940032862253633,119.468044435491,-0.0752285585987755,NA,4692673.51081266,0.384555509373631,1,0,0,188.544222231268,0.999999999999997,"lineage5","other_mutations_pyrazinamide","VAL",0,"ERR2707138","ERR2707138","lineage5","cd","Democratic Republic of Congo","pnca_p.phe58val","A","B","PHE","FA58","pnca_complex.pdb"
|
|
"F58V","L2","PZA","F","F58",58,"V",NA,"Pre-MDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",8.072,-2.319,-1.927,1.56433,-1.103,-1.7,71,85,-1.108,9,9,43,0.179166666666667,"strand",-0.4,4.41,7.18700589334483e-05,2.42412778478352,0.0001249735077034,0,1.03410070803344e-29,28,2,0,0,2,0,0,0,0,0,0,2,-2,0,0,0,0,-2,0,-2,2,4,0,8,-2,-0.587386018237082,-0.497932816537468,0.0569763037318162,-0.188064791133845,-0.445026178010471,0.747368421052632,-0.912685337726524,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.178,-1.062,"9:9","148/150","W:I:F",-8.98740878149641,0.940032862253633,119.468044435491,-0.0752285585987755,NA,4692673.51081266,0.384555509373631,1,0,0,188.544222231268,0.999999999999997,"lineage2","other_mutations_pyrazinamide","VAL",0,"SRR5073601","SRR5073601","lineage2.2.1.1","vn","Vietnam","pnca_p.phe58val","A","B","PHE","FA58","pnca_complex.pdb"
|
|
"F58V","L2","PZA","F","F58",58,"V",0,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",8.072,-2.319,-1.927,1.56433,-1.103,-1.7,71,85,-1.108,9,9,43,0.179166666666667,"strand",-0.4,4.41,7.18700589334483e-05,2.42412778478352,0.0001249735077034,0,1.03410070803344e-29,28,2,0,0,2,0,0,0,0,0,0,2,-2,0,0,0,0,-2,0,-2,2,4,0,8,-2,-0.587386018237082,-0.497932816537468,0.0569763037318162,-0.188064791133845,-0.445026178010471,0.747368421052632,-0.912685337726524,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.178,-1.062,"9:9","148/150","W:I:F",-8.98740878149641,0.940032862253633,119.468044435491,-0.0752285585987755,NA,4692673.51081266,0.384555509373631,1,0,0,188.544222231268,0.999999999999997,"lineage2","other_mutations_pyrazinamide","VAL",0,"ETB0039","SRR6257085","lineage2.2.1","ru","Russia:Kaluga","pnca_p.phe58val","A","B","PHE","FA58","pnca_complex.pdb"
|
|
"S59F","L4","PZA","S","S59",59,"F",NA,"MDR","DM","hydrophilic","hydrophobic","neutral","non-polar","polar","non-polar",11.829,-0.598,-0.905,0.176045,-1.083,-0.74,56,75,-0.671,7,7,38,0.245161290322581,"loop",0.533333333333333,3.86,7.18700589334483e-05,9.70142977291842,188179.926264404,Inf,0.763784339928386,-14,-2,0,0,-2,0,0,0,0,2,0,2,0,0,0,0,0,-3,0,-1,-2,-2,0,-4,-2,-0.151469098277609,-0.233850129198966,0.00641194210330786,-0.184654731457801,-0.193717277486911,0.589473684210526,-0.552718286655684,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.779,-0.615,"8:7","148/150","T:G:A:S:Q:H:E:K:R:L:V",12.1451538387252,0.919026337424193,119.468044436159,0.101660271548307,5.01153666069521e-06,NA,0.986835744238421,0.170978870202674,0.767057556984365,0.124324963210678,Inf,0.382146811758261,"lineage4","dr_mutations_pyrazinamide","PHE",0,"ERR2707143","ERR2707143","lineage4.3.3","cd","Democratic Republic of Congo","pnca_p.ser59phe","A","-","SER","SA59","pnca_complex.pdb"
|
|
"S59F","L4","PZA","S","S59",59,"F",1,"Pre-XDR","DM","hydrophilic","hydrophobic","neutral","non-polar","polar","non-polar",11.829,-0.598,-0.905,0.176045,-1.083,-0.74,56,75,-0.671,7,7,38,0.245161290322581,"loop",0.533333333333333,3.86,7.18700589334483e-05,9.70142977291842,188179.926264404,Inf,0.763784339928386,-14,-2,0,0,-2,0,0,0,0,2,0,2,0,0,0,0,0,-3,0,-1,-2,-2,0,-4,-2,-0.151469098277609,-0.233850129198966,0.00641194210330786,-0.184654731457801,-0.193717277486911,0.589473684210526,-0.552718286655684,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.779,-0.615,"8:7","148/150","T:G:A:S:Q:H:E:K:R:L:V",12.1451538387252,0.919026337424193,119.468044436159,0.101660271548307,5.01153666069521e-06,NA,0.986835744238421,0.170978870202674,0.767057556984365,0.124324963210678,Inf,0.382146811758261,"lineage4","dr_mutations_pyrazinamide","PHE",0,"ERR2516572","ERR2516572","lineage4.3.4.2","pe","Peru","pnca_p.ser59phe","A","-","SER","SA59","pnca_complex.pdb"
|
|
"S59F","L4","PZA","S","S59",59,"F",NA,"MDR","DM","hydrophilic","hydrophobic","neutral","non-polar","polar","non-polar",11.829,-0.598,-0.905,0.176045,-1.083,-0.74,56,75,-0.671,7,7,38,0.245161290322581,"loop",0.533333333333333,3.86,7.18700589334483e-05,9.70142977291842,188179.926264404,Inf,0.763784339928386,-14,-2,0,0,-2,0,0,0,0,2,0,2,0,0,0,0,0,-3,0,-1,-2,-2,0,-4,-2,-0.151469098277609,-0.233850129198966,0.00641194210330786,-0.184654731457801,-0.193717277486911,0.589473684210526,-0.552718286655684,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.779,-0.615,"8:7","148/150","T:G:A:S:Q:H:E:K:R:L:V",12.1451538387252,0.919026337424193,119.468044436159,0.101660271548307,5.01153666069521e-06,NA,0.986835744238421,0.170978870202674,0.767057556984365,0.124324963210678,Inf,0.382146811758261,"lineage4","dr_mutations_pyrazinamide","PHE",0,"SRR8003011","SRR8003011","lineage4.8","in","India","pnca_p.ser59phe","A","-","SER","SA59","pnca_complex.pdb"
|
|
"S59P","L4","PZA","S","S59",59,"P",NA,"MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",11.829,-1.097,-0.594,3.6058,-1.13,-0.16,62,80,-0.671,7,7,38,0.245161290322581,"loop",0.533333333333333,3.86,0.0004312203536006,58.3312262958281,1393450.94022764,Inf,23.547488635408,0,0,0,0,0,0,0,0,0,4,2,2,0,0,0,0,0,-6,0,-4,-2,-2,0,-4,-6,-0.277862208713272,-0.153488372093023,0.131331084870956,-0.192668371696505,-0.0418848167539267,0.652631578947368,-0.552718286655684,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.779,-0.615,"8:7","148/150","T:G:A:S:Q:H:E:K:R:L:V",14.1472939191327,0.915018435775139,132.57606067652,0.106710773022978,4.17896182039693,NA,1.7659011066874,2.48532104922106e-05,4.60461750194108,5.71767556863798,Inf,1.21868387173808e-06,"lineage4","dr_mutations_pyrazinamide","PRO",0,"SAMN02403622","SRR1175510_SRR1175516","lineage4.8","za","South Africa","pnca_p.ser59pro","A","-","SER","SA59","pnca_complex.pdb"
|
|
"S59P","L4","PZA","S","S59",59,"P",NA,"MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",11.829,-1.097,-0.594,3.6058,-1.13,-0.16,62,80,-0.671,7,7,38,0.245161290322581,"loop",0.533333333333333,3.86,0.0004312203536006,58.3312262958281,1393450.94022764,Inf,23.547488635408,0,0,0,0,0,0,0,0,0,4,2,2,0,0,0,0,0,-6,0,-4,-2,-2,0,-4,-6,-0.277862208713272,-0.153488372093023,0.131331084870956,-0.192668371696505,-0.0418848167539267,0.652631578947368,-0.552718286655684,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.779,-0.615,"8:7","148/150","T:G:A:S:Q:H:E:K:R:L:V",14.1472939191327,0.915018435775139,132.57606067652,0.106710773022978,4.17896182039693,NA,1.7659011066874,2.48532104922106e-05,4.60461750194108,5.71767556863798,Inf,1.21868387173808e-06,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR2707107","ERR2707107","lineage4.3.4.2","cd","Democratic Republic of Congo","pnca_p.ser59pro","A","-","SER","SA59","pnca_complex.pdb"
|
|
"S59P","L4","PZA","S","S59",59,"P",NA,"MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",11.829,-1.097,-0.594,3.6058,-1.13,-0.16,62,80,-0.671,7,7,38,0.245161290322581,"loop",0.533333333333333,3.86,0.0004312203536006,58.3312262958281,1393450.94022764,Inf,23.547488635408,0,0,0,0,0,0,0,0,0,4,2,2,0,0,0,0,0,-6,0,-4,-2,-2,0,-4,-6,-0.277862208713272,-0.153488372093023,0.131331084870956,-0.192668371696505,-0.0418848167539267,0.652631578947368,-0.552718286655684,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.779,-0.615,"8:7","148/150","T:G:A:S:Q:H:E:K:R:L:V",14.1472939191327,0.915018435775139,132.57606067652,0.106710773022978,4.17896182039693,NA,1.7659011066874,2.48532104922106e-05,4.60461750194108,5.71767556863798,Inf,1.21868387173808e-06,"lineage4","dr_mutations_pyrazinamide","PRO",0,"SAMN02403508","SRR1167269_SRR1173278_SRR1165265_SRR1173785","lineage4.8","za","South Africa","pnca_p.ser59pro","A","-","SER","SA59","pnca_complex.pdb"
|
|
"S59P","L4","PZA","S","S59",59,"P",NA,"MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",11.829,-1.097,-0.594,3.6058,-1.13,-0.16,62,80,-0.671,7,7,38,0.245161290322581,"loop",0.533333333333333,3.86,0.0004312203536006,58.3312262958281,1393450.94022764,Inf,23.547488635408,0,0,0,0,0,0,0,0,0,4,2,2,0,0,0,0,0,-6,0,-4,-2,-2,0,-4,-6,-0.277862208713272,-0.153488372093023,0.131331084870956,-0.192668371696505,-0.0418848167539267,0.652631578947368,-0.552718286655684,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.779,-0.615,"8:7","148/150","T:G:A:S:Q:H:E:K:R:L:V",14.1472939191327,0.915018435775139,132.57606067652,0.106710773022978,4.17896182039693,NA,1.7659011066874,2.48532104922106e-05,4.60461750194108,5.71767556863798,Inf,1.21868387173808e-06,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR2515152","ERR2515152","lineage4.8","za","South Africa","pnca_p.ser59pro","A","-","SER","SA59","pnca_complex.pdb"
|
|
"S59P","L4","PZA","S","S59",59,"P",NA,"MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",11.829,-1.097,-0.594,3.6058,-1.13,-0.16,62,80,-0.671,7,7,38,0.245161290322581,"loop",0.533333333333333,3.86,0.0004312203536006,58.3312262958281,1393450.94022764,Inf,23.547488635408,0,0,0,0,0,0,0,0,0,4,2,2,0,0,0,0,0,-6,0,-4,-2,-2,0,-4,-6,-0.277862208713272,-0.153488372093023,0.131331084870956,-0.192668371696505,-0.0418848167539267,0.652631578947368,-0.552718286655684,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.779,-0.615,"8:7","148/150","T:G:A:S:Q:H:E:K:R:L:V",14.1472939191327,0.915018435775139,132.57606067652,0.106710773022978,4.17896182039693,NA,1.7659011066874,2.48532104922106e-05,4.60461750194108,5.71767556863798,Inf,1.21868387173808e-06,"lineage4","dr_mutations_pyrazinamide","PRO",0,"SAMN02403598","SRR1167386_SRR1165715_SRR1169293_SRR1169201","lineage4.8","za","South Africa","pnca_p.ser59pro","A","-","SER","SA59","pnca_complex.pdb"
|
|
"S59P","L4","PZA","S","S59",59,"P",1,"MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",11.829,-1.097,-0.594,3.6058,-1.13,-0.16,62,80,-0.671,7,7,38,0.245161290322581,"loop",0.533333333333333,3.86,0.0004312203536006,58.3312262958281,1393450.94022764,Inf,23.547488635408,0,0,0,0,0,0,0,0,0,4,2,2,0,0,0,0,0,-6,0,-4,-2,-2,0,-4,-6,-0.277862208713272,-0.153488372093023,0.131331084870956,-0.192668371696505,-0.0418848167539267,0.652631578947368,-0.552718286655684,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.779,-0.615,"8:7","148/150","T:G:A:S:Q:H:E:K:R:L:V",14.1472939191327,0.915018435775139,132.57606067652,0.106710773022978,4.17896182039693,NA,1.7659011066874,2.48532104922106e-05,4.60461750194108,5.71767556863798,Inf,1.21868387173808e-06,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR2515713","ERR2515713","lineage4.8","za","South Africa","pnca_p.ser59pro","A","-","SER","SA59","pnca_complex.pdb"
|
|
"S59P","L4","PZA","S","S59",59,"P",NA,"MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",11.829,-1.097,-0.594,3.6058,-1.13,-0.16,62,80,-0.671,7,7,38,0.245161290322581,"loop",0.533333333333333,3.86,0.0004312203536006,58.3312262958281,1393450.94022764,Inf,23.547488635408,0,0,0,0,0,0,0,0,0,4,2,2,0,0,0,0,0,-6,0,-4,-2,-2,0,-4,-6,-0.277862208713272,-0.153488372093023,0.131331084870956,-0.192668371696505,-0.0418848167539267,0.652631578947368,-0.552718286655684,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.779,-0.615,"8:7","148/150","T:G:A:S:Q:H:E:K:R:L:V",14.1472939191327,0.915018435775139,132.57606067652,0.106710773022978,4.17896182039693,NA,1.7659011066874,2.48532104922106e-05,4.60461750194108,5.71767556863798,Inf,1.21868387173808e-06,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR2707204","ERR2707204","lineage4.3.4.2","cd","Democratic Republic of Congo","pnca_p.ser59pro","A","-","SER","SA59","pnca_complex.pdb"
|
|
"S59P","L2","PZA","S","S59",59,"P",NA,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",11.829,-1.097,-0.594,3.6058,-1.13,-0.16,62,80,-0.671,7,7,38,0.245161290322581,"loop",0.533333333333333,3.86,0.0004312203536006,58.3312262958281,1393450.94022764,Inf,23.547488635408,0,0,0,0,0,0,0,0,0,4,2,2,0,0,0,0,0,-6,0,-4,-2,-2,0,-4,-6,-0.277862208713272,-0.153488372093023,0.131331084870956,-0.192668371696505,-0.0418848167539267,0.652631578947368,-0.552718286655684,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.779,-0.615,"8:7","148/150","T:G:A:S:Q:H:E:K:R:L:V",14.1472939191327,0.915018435775139,132.57606067652,0.106710773022978,4.17896182039693,NA,1.7659011066874,2.48532104922106e-05,4.60461750194108,5.71767556863798,Inf,1.21868387173808e-06,"lineage2","dr_mutations_pyrazinamide","PRO",0,"ERR019860","ERR019860","lineage2.2.1","","Russia,UK","pnca_p.ser59pro","A","-","SER","SA59","pnca_complex.pdb"
|
|
"S59P","L4","PZA","S","S59",59,"P",NA,"Pre-MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",11.829,-1.097,-0.594,3.6058,-1.13,-0.16,62,80,-0.671,7,7,38,0.245161290322581,"loop",0.533333333333333,3.86,0.0004312203536006,58.3312262958281,1393450.94022764,Inf,23.547488635408,0,0,0,0,0,0,0,0,0,4,2,2,0,0,0,0,0,-6,0,-4,-2,-2,0,-4,-6,-0.277862208713272,-0.153488372093023,0.131331084870956,-0.192668371696505,-0.0418848167539267,0.652631578947368,-0.552718286655684,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.779,-0.615,"8:7","148/150","T:G:A:S:Q:H:E:K:R:L:V",14.1472939191327,0.915018435775139,132.57606067652,0.106710773022978,4.17896182039693,NA,1.7659011066874,2.48532104922106e-05,4.60461750194108,5.71767556863798,Inf,1.21868387173808e-06,"lineage4","dr_mutations_pyrazinamide","PRO",0,"BGI_FJ05189,SRR671757","SRR671757","lineage4.5","cn","China","pnca_p.ser59pro","A","-","SER","SA59","pnca_complex.pdb"
|
|
"S59P","L4","PZA","S","S59",59,"P",NA,"XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",11.829,-1.097,-0.594,3.6058,-1.13,-0.16,62,80,-0.671,7,7,38,0.245161290322581,"loop",0.533333333333333,3.86,0.0004312203536006,58.3312262958281,1393450.94022764,Inf,23.547488635408,0,0,0,0,0,0,0,0,0,4,2,2,0,0,0,0,0,-6,0,-4,-2,-2,0,-4,-6,-0.277862208713272,-0.153488372093023,0.131331084870956,-0.192668371696505,-0.0418848167539267,0.652631578947368,-0.552718286655684,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.779,-0.615,"8:7","148/150","T:G:A:S:Q:H:E:K:R:L:V",14.1472939191327,0.915018435775139,132.57606067652,0.106710773022978,4.17896182039693,NA,1.7659011066874,2.48532104922106e-05,4.60461750194108,5.71767556863798,Inf,1.21868387173808e-06,"lineage4","dr_mutations_pyrazinamide","PRO",0,"SAMN02403509","SRR1173443_SRR1173248_SRR1165276_SRR1167294","lineage4.8","za","South Africa","pnca_p.ser59pro","A","-","SER","SA59","pnca_complex.pdb"
|
|
"S59P","L4","PZA","S","S59",59,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",11.829,-1.097,-0.594,3.6058,-1.13,-0.16,62,80,-0.671,7,7,38,0.245161290322581,"loop",0.533333333333333,3.86,0.0004312203536006,58.3312262958281,1393450.94022764,Inf,23.547488635408,0,0,0,0,0,0,0,0,0,4,2,2,0,0,0,0,0,-6,0,-4,-2,-2,0,-4,-6,-0.277862208713272,-0.153488372093023,0.131331084870956,-0.192668371696505,-0.0418848167539267,0.652631578947368,-0.552718286655684,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.779,-0.615,"8:7","148/150","T:G:A:S:Q:H:E:K:R:L:V",14.1472939191327,0.915018435775139,132.57606067652,0.106710773022978,4.17896182039693,NA,1.7659011066874,2.48532104922106e-05,4.60461750194108,5.71767556863798,Inf,1.21868387173808e-06,"lineage4","dr_mutations_pyrazinamide","PRO",0,"SAMN02350418","SRR1011459_SRR1062829","lineage4.8","za","South Africa","pnca_p.ser59pro","A","-","SER","SA59","pnca_complex.pdb"
|
|
"S59P","L2","PZA","S","S59",59,"P",NA,"MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",11.829,-1.097,-0.594,3.6058,-1.13,-0.16,62,80,-0.671,7,7,38,0.245161290322581,"loop",0.533333333333333,3.86,0.0004312203536006,58.3312262958281,1393450.94022764,Inf,23.547488635408,0,0,0,0,0,0,0,0,0,4,2,2,0,0,0,0,0,-6,0,-4,-2,-2,0,-4,-6,-0.277862208713272,-0.153488372093023,0.131331084870956,-0.192668371696505,-0.0418848167539267,0.652631578947368,-0.552718286655684,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.779,-0.615,"8:7","148/150","T:G:A:S:Q:H:E:K:R:L:V",14.1472939191327,0.915018435775139,132.57606067652,0.106710773022978,4.17896182039693,NA,1.7659011066874,2.48532104922106e-05,4.60461750194108,5.71767556863798,Inf,1.21868387173808e-06,"lineage2","dr_mutations_pyrazinamide","PRO",0,"SRS797086","SRR1723591","lineage2.2.1","cn","China:Ningxia","pnca_p.ser59pro","A","-","SER","SA59","pnca_complex.pdb"
|
|
"S59P","L4","PZA","S","S59",59,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",11.829,-1.097,-0.594,3.6058,-1.13,-0.16,62,80,-0.671,7,7,38,0.245161290322581,"loop",0.533333333333333,3.86,0.0004312203536006,58.3312262958281,1393450.94022764,Inf,23.547488635408,0,0,0,0,0,0,0,0,0,4,2,2,0,0,0,0,0,-6,0,-4,-2,-2,0,-4,-6,-0.277862208713272,-0.153488372093023,0.131331084870956,-0.192668371696505,-0.0418848167539267,0.652631578947368,-0.552718286655684,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.779,-0.615,"8:7","148/150","T:G:A:S:Q:H:E:K:R:L:V",14.1472939191327,0.915018435775139,132.57606067652,0.106710773022978,4.17896182039693,NA,1.7659011066874,2.48532104922106e-05,4.60461750194108,5.71767556863798,Inf,1.21868387173808e-06,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR2516329","ERR2516329","lineage4.3.4.2","be","Belgium","pnca_p.ser59pro","A","-","SER","SA59","pnca_complex.pdb"
|
|
"S59P","L1","PZA","S","S59",59,"P",NA,"MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",11.829,-1.097,-0.594,3.6058,-1.13,-0.16,62,80,-0.671,7,7,38,0.245161290322581,"loop",0.533333333333333,3.86,0.0004312203536006,58.3312262958281,1393450.94022764,Inf,23.547488635408,0,0,0,0,0,0,0,0,0,4,2,2,0,0,0,0,0,-6,0,-4,-2,-2,0,-4,-6,-0.277862208713272,-0.153488372093023,0.131331084870956,-0.192668371696505,-0.0418848167539267,0.652631578947368,-0.552718286655684,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.779,-0.615,"8:7","148/150","T:G:A:S:Q:H:E:K:R:L:V",14.1472939191327,0.915018435775139,132.57606067652,0.106710773022978,4.17896182039693,NA,1.7659011066874,2.48532104922106e-05,4.60461750194108,5.71767556863798,Inf,1.21868387173808e-06,"lineage1","dr_mutations_pyrazinamide","PRO",0,"ERR3256119","ERR3256119","lineage1.2.1","ph","Philippines","pnca_p.ser59pro","A","-","SER","SA59","pnca_complex.pdb"
|
|
"S59P","L4","PZA","S","S59",59,"P",NA,"MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",11.829,-1.097,-0.594,3.6058,-1.13,-0.16,62,80,-0.671,7,7,38,0.245161290322581,"loop",0.533333333333333,3.86,0.0004312203536006,58.3312262958281,1393450.94022764,Inf,23.547488635408,0,0,0,0,0,0,0,0,0,4,2,2,0,0,0,0,0,-6,0,-4,-2,-2,0,-4,-6,-0.277862208713272,-0.153488372093023,0.131331084870956,-0.192668371696505,-0.0418848167539267,0.652631578947368,-0.552718286655684,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.779,-0.615,"8:7","148/150","T:G:A:S:Q:H:E:K:R:L:V",14.1472939191327,0.915018435775139,132.57606067652,0.106710773022978,4.17896182039693,NA,1.7659011066874,2.48532104922106e-05,4.60461750194108,5.71767556863798,Inf,1.21868387173808e-06,"lineage4","dr_mutations_pyrazinamide","PRO",0,"SAMN02350437","SRR1011480_SRR1062851","lineage4.8","za","South Africa","pnca_p.ser59pro","A","-","SER","SA59","pnca_complex.pdb"
|
|
"S59P","L4","PZA","S","S59",59,"P",NA,"MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",11.829,-1.097,-0.594,3.6058,-1.13,-0.16,62,80,-0.671,7,7,38,0.245161290322581,"loop",0.533333333333333,3.86,0.0004312203536006,58.3312262958281,1393450.94022764,Inf,23.547488635408,0,0,0,0,0,0,0,0,0,4,2,2,0,0,0,0,0,-6,0,-4,-2,-2,0,-4,-6,-0.277862208713272,-0.153488372093023,0.131331084870956,-0.192668371696505,-0.0418848167539267,0.652631578947368,-0.552718286655684,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.779,-0.615,"8:7","148/150","T:G:A:S:Q:H:E:K:R:L:V",14.1472939191327,0.915018435775139,132.57606067652,0.106710773022978,4.17896182039693,NA,1.7659011066874,2.48532104922106e-05,4.60461750194108,5.71767556863798,Inf,1.21868387173808e-06,"lineage4","dr_mutations_pyrazinamide","PRO",0,"SAMN02586042","SRR1196512_SRR1172754_SRR1184295_SRR1175083","lineage4.8","za","South Africa","pnca_p.ser59pro","A","-","SER","SA59","pnca_complex.pdb"
|
|
"S59P","L4","PZA","S","S59",59,"P",NA,"XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",11.829,-1.097,-0.594,3.6058,-1.13,-0.16,62,80,-0.671,7,7,38,0.245161290322581,"loop",0.533333333333333,3.86,0.0004312203536006,58.3312262958281,1393450.94022764,Inf,23.547488635408,0,0,0,0,0,0,0,0,0,4,2,2,0,0,0,0,0,-6,0,-4,-2,-2,0,-4,-6,-0.277862208713272,-0.153488372093023,0.131331084870956,-0.192668371696505,-0.0418848167539267,0.652631578947368,-0.552718286655684,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.779,-0.615,"8:7","148/150","T:G:A:S:Q:H:E:K:R:L:V",14.1472939191327,0.915018435775139,132.57606067652,0.106710773022978,4.17896182039693,NA,1.7659011066874,2.48532104922106e-05,4.60461750194108,5.71767556863798,Inf,1.21868387173808e-06,"lineage4","dr_mutations_pyrazinamide","PRO",0,"SAMN02350419","SRR1011460_SRR1062832","lineage4.8","za","South Africa","pnca_p.ser59pro","A","-","SER","SA59","pnca_complex.pdb"
|
|
"S59P","L4","PZA","S","S59",59,"P",NA,"MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",11.829,-1.097,-0.594,3.6058,-1.13,-0.16,62,80,-0.671,7,7,38,0.245161290322581,"loop",0.533333333333333,3.86,0.0004312203536006,58.3312262958281,1393450.94022764,Inf,23.547488635408,0,0,0,0,0,0,0,0,0,4,2,2,0,0,0,0,0,-6,0,-4,-2,-2,0,-4,-6,-0.277862208713272,-0.153488372093023,0.131331084870956,-0.192668371696505,-0.0418848167539267,0.652631578947368,-0.552718286655684,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.779,-0.615,"8:7","148/150","T:G:A:S:Q:H:E:K:R:L:V",14.1472939191327,0.915018435775139,132.57606067652,0.106710773022978,4.17896182039693,NA,1.7659011066874,2.48532104922106e-05,4.60461750194108,5.71767556863798,Inf,1.21868387173808e-06,"lineage4","dr_mutations_pyrazinamide","PRO",0,"SAMN02403599","SRR1172261_SRR1165719_SRR1165701_SRR1169149","lineage4.8","za","South Africa","pnca_p.ser59pro","A","-","SER","SA59","pnca_complex.pdb"
|
|
"S59P","L4","PZA","S","S59",59,"P",NA,"MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",11.829,-1.097,-0.594,3.6058,-1.13,-0.16,62,80,-0.671,7,7,38,0.245161290322581,"loop",0.533333333333333,3.86,0.0004312203536006,58.3312262958281,1393450.94022764,Inf,23.547488635408,0,0,0,0,0,0,0,0,0,4,2,2,0,0,0,0,0,-6,0,-4,-2,-2,0,-4,-6,-0.277862208713272,-0.153488372093023,0.131331084870956,-0.192668371696505,-0.0418848167539267,0.652631578947368,-0.552718286655684,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.779,-0.615,"8:7","148/150","T:G:A:S:Q:H:E:K:R:L:V",14.1472939191327,0.915018435775139,132.57606067652,0.106710773022978,4.17896182039693,NA,1.7659011066874,2.48532104922106e-05,4.60461750194108,5.71767556863798,Inf,1.21868387173808e-06,"lineage4","dr_mutations_pyrazinamide","PRO",0,"SAMN02350438","SRR1011481_SRR1062852","lineage4.8","za","South Africa","pnca_p.ser59pro","A","-","SER","SA59","pnca_complex.pdb"
|
|
"S59P","L3","PZA","S","S59",59,"P",NA,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",11.829,-1.097,-0.594,3.6058,-1.13,-0.16,62,80,-0.671,7,7,38,0.245161290322581,"loop",0.533333333333333,3.86,0.0004312203536006,58.3312262958281,1393450.94022764,Inf,23.547488635408,0,0,0,0,0,0,0,0,0,4,2,2,0,0,0,0,0,-6,0,-4,-2,-2,0,-4,-6,-0.277862208713272,-0.153488372093023,0.131331084870956,-0.192668371696505,-0.0418848167539267,0.652631578947368,-0.552718286655684,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.779,-0.615,"8:7","148/150","T:G:A:S:Q:H:E:K:R:L:V",14.1472939191327,0.915018435775139,132.57606067652,0.106710773022978,4.17896182039693,NA,1.7659011066874,2.48532104922106e-05,4.60461750194108,5.71767556863798,Inf,1.21868387173808e-06,"lineage3","dr_mutations_pyrazinamide","PRO",0,"SAMN09708336","SRR7585398","lineage3","in","India","pnca_p.ser59pro","A","-","SER","SA59","pnca_complex.pdb"
|
|
"S59P","L4","PZA","S","S59",59,"P",NA,"MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",11.829,-1.097,-0.594,3.6058,-1.13,-0.16,62,80,-0.671,7,7,38,0.245161290322581,"loop",0.533333333333333,3.86,0.0004312203536006,58.3312262958281,1393450.94022764,Inf,23.547488635408,0,0,0,0,0,0,0,0,0,4,2,2,0,0,0,0,0,-6,0,-4,-2,-2,0,-4,-6,-0.277862208713272,-0.153488372093023,0.131331084870956,-0.192668371696505,-0.0418848167539267,0.652631578947368,-0.552718286655684,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.779,-0.615,"8:7","148/150","T:G:A:S:Q:H:E:K:R:L:V",14.1472939191327,0.915018435775139,132.57606067652,0.106710773022978,4.17896182039693,NA,1.7659011066874,2.48532104922106e-05,4.60461750194108,5.71767556863798,Inf,1.21868387173808e-06,"lineage4","dr_mutations_pyrazinamide","PRO",0,"SAMN02403613","SRR1165697_SRR1169331_SRR1165689_SRR1169213","lineage4.8","za","South Africa","pnca_p.ser59pro","A","-","SER","SA59","pnca_complex.pdb"
|
|
"S59P","L2","PZA","S","S59",59,"P",NA,"MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",11.829,-1.097,-0.594,3.6058,-1.13,-0.16,62,80,-0.671,7,7,38,0.245161290322581,"loop",0.533333333333333,3.86,0.0004312203536006,58.3312262958281,1393450.94022764,Inf,23.547488635408,0,0,0,0,0,0,0,0,0,4,2,2,0,0,0,0,0,-6,0,-4,-2,-2,0,-4,-6,-0.277862208713272,-0.153488372093023,0.131331084870956,-0.192668371696505,-0.0418848167539267,0.652631578947368,-0.552718286655684,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.779,-0.615,"8:7","148/150","T:G:A:S:Q:H:E:K:R:L:V",14.1472939191327,0.915018435775139,132.57606067652,0.106710773022978,4.17896182039693,NA,1.7659011066874,2.48532104922106e-05,4.60461750194108,5.71767556863798,Inf,1.21868387173808e-06,"lineage2","dr_mutations_pyrazinamide","PRO",0,"DRR184619","DRR184619","lineage2.2.1","vn","Vietnam","pnca_p.ser59pro","A","-","SER","SA59","pnca_complex.pdb"
|
|
"S59P","L4","PZA","S","S59",59,"P",NA,"MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",11.829,-1.097,-0.594,3.6058,-1.13,-0.16,62,80,-0.671,7,7,38,0.245161290322581,"loop",0.533333333333333,3.86,0.0004312203536006,58.3312262958281,1393450.94022764,Inf,23.547488635408,0,0,0,0,0,0,0,0,0,4,2,2,0,0,0,0,0,-6,0,-4,-2,-2,0,-4,-6,-0.277862208713272,-0.153488372093023,0.131331084870956,-0.192668371696505,-0.0418848167539267,0.652631578947368,-0.552718286655684,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.779,-0.615,"8:7","148/150","T:G:A:S:Q:H:E:K:R:L:V",14.1472939191327,0.915018435775139,132.57606067652,0.106710773022978,4.17896182039693,NA,1.7659011066874,2.48532104922106e-05,4.60461750194108,5.71767556863798,Inf,1.21868387173808e-06,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR2707136","ERR2707136","lineage4.3.4.2","cd","Democratic Republic of Congo","pnca_p.ser59pro","A","-","SER","SA59","pnca_complex.pdb"
|
|
"S59P","L2","PZA","S","S59",59,"P",1,"MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",11.829,-1.097,-0.594,3.6058,-1.13,-0.16,62,80,-0.671,7,7,38,0.245161290322581,"loop",0.533333333333333,3.86,0.0004312203536006,58.3312262958281,1393450.94022764,Inf,23.547488635408,0,0,0,0,0,0,0,0,0,4,2,2,0,0,0,0,0,-6,0,-4,-2,-2,0,-4,-6,-0.277862208713272,-0.153488372093023,0.131331084870956,-0.192668371696505,-0.0418848167539267,0.652631578947368,-0.552718286655684,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.779,-0.615,"8:7","148/150","T:G:A:S:Q:H:E:K:R:L:V",14.1472939191327,0.915018435775139,132.57606067652,0.106710773022978,4.17896182039693,NA,1.7659011066874,2.48532104922106e-05,4.60461750194108,5.71767556863798,Inf,1.21868387173808e-06,"lineage2","dr_mutations_pyrazinamide","PRO",0,"MDR_30118","SRR6824311","lineage2.2.1","cn","China: Haiyuan County, Ningxia Zhongwei City, Ningxia Province","pnca_p.ser59pro","A","-","SER","SA59","pnca_complex.pdb"
|
|
"S59P","L4","PZA","S","S59",59,"P",NA,"MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",11.829,-1.097,-0.594,3.6058,-1.13,-0.16,62,80,-0.671,7,7,38,0.245161290322581,"loop",0.533333333333333,3.86,0.0004312203536006,58.3312262958281,1393450.94022764,Inf,23.547488635408,0,0,0,0,0,0,0,0,0,4,2,2,0,0,0,0,0,-6,0,-4,-2,-2,0,-4,-6,-0.277862208713272,-0.153488372093023,0.131331084870956,-0.192668371696505,-0.0418848167539267,0.652631578947368,-0.552718286655684,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.779,-0.615,"8:7","148/150","T:G:A:S:Q:H:E:K:R:L:V",14.1472939191327,0.915018435775139,132.57606067652,0.106710773022978,4.17896182039693,NA,1.7659011066874,2.48532104922106e-05,4.60461750194108,5.71767556863798,Inf,1.21868387173808e-06,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR2707225","ERR2707225","lineage4.3.4.2","cd","Democratic Republic of Congo","pnca_p.ser59pro","A","-","SER","SA59","pnca_complex.pdb"
|
|
"S59P","L4","PZA","S","S59",59,"P",1,"MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",11.829,-1.097,-0.594,3.6058,-1.13,-0.16,62,80,-0.671,7,7,38,0.245161290322581,"loop",0.533333333333333,3.86,0.0004312203536006,58.3312262958281,1393450.94022764,Inf,23.547488635408,0,0,0,0,0,0,0,0,0,4,2,2,0,0,0,0,0,-6,0,-4,-2,-2,0,-4,-6,-0.277862208713272,-0.153488372093023,0.131331084870956,-0.192668371696505,-0.0418848167539267,0.652631578947368,-0.552718286655684,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.779,-0.615,"8:7","148/150","T:G:A:S:Q:H:E:K:R:L:V",14.1472939191327,0.915018435775139,132.57606067652,0.106710773022978,4.17896182039693,NA,1.7659011066874,2.48532104922106e-05,4.60461750194108,5.71767556863798,Inf,1.21868387173808e-06,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR552701","ERR552701","lineage4.8","sz","Swaziland","pnca_p.ser59pro","A","-","SER","SA59","pnca_complex.pdb"
|
|
"S59P","L4","PZA","S","S59",59,"P",1,"MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",11.829,-1.097,-0.594,3.6058,-1.13,-0.16,62,80,-0.671,7,7,38,0.245161290322581,"loop",0.533333333333333,3.86,0.0004312203536006,58.3312262958281,1393450.94022764,Inf,23.547488635408,0,0,0,0,0,0,0,0,0,4,2,2,0,0,0,0,0,-6,0,-4,-2,-2,0,-4,-6,-0.277862208713272,-0.153488372093023,0.131331084870956,-0.192668371696505,-0.0418848167539267,0.652631578947368,-0.552718286655684,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.779,-0.615,"8:7","148/150","T:G:A:S:Q:H:E:K:R:L:V",14.1472939191327,0.915018435775139,132.57606067652,0.106710773022978,4.17896182039693,NA,1.7659011066874,2.48532104922106e-05,4.60461750194108,5.71767556863798,Inf,1.21868387173808e-06,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR2515202","ERR2515202","lineage4.8","za","South Africa","pnca_p.ser59pro","A","-","SER","SA59","pnca_complex.pdb"
|
|
"S59P","L2","PZA","S","S59",59,"P",NA,"Pre-MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",11.829,-1.097,-0.594,3.6058,-1.13,-0.16,62,80,-0.671,7,7,38,0.245161290322581,"loop",0.533333333333333,3.86,0.0004312203536006,58.3312262958281,1393450.94022764,Inf,23.547488635408,0,0,0,0,0,0,0,0,0,4,2,2,0,0,0,0,0,-6,0,-4,-2,-2,0,-4,-6,-0.277862208713272,-0.153488372093023,0.131331084870956,-0.192668371696505,-0.0418848167539267,0.652631578947368,-0.552718286655684,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.779,-0.615,"8:7","148/150","T:G:A:S:Q:H:E:K:R:L:V",14.1472939191327,0.915018435775139,132.57606067652,0.106710773022978,4.17896182039693,NA,1.7659011066874,2.48532104922106e-05,4.60461750194108,5.71767556863798,Inf,1.21868387173808e-06,"lineage2","dr_mutations_pyrazinamide","PRO",0,"SRR5067605","SRR5067605","lineage2.2.1.1","vn","Vietnam","pnca_p.ser59pro","A","-","SER","SA59","pnca_complex.pdb"
|
|
"S59P","L4","PZA","S","S59",59,"P",NA,"MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",11.829,-1.097,-0.594,3.6058,-1.13,-0.16,62,80,-0.671,7,7,38,0.245161290322581,"loop",0.533333333333333,3.86,0.0004312203536006,58.3312262958281,1393450.94022764,Inf,23.547488635408,0,0,0,0,0,0,0,0,0,4,2,2,0,0,0,0,0,-6,0,-4,-2,-2,0,-4,-6,-0.277862208713272,-0.153488372093023,0.131331084870956,-0.192668371696505,-0.0418848167539267,0.652631578947368,-0.552718286655684,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.779,-0.615,"8:7","148/150","T:G:A:S:Q:H:E:K:R:L:V",14.1472939191327,0.915018435775139,132.57606067652,0.106710773022978,4.17896182039693,NA,1.7659011066874,2.48532104922106e-05,4.60461750194108,5.71767556863798,Inf,1.21868387173808e-06,"lineage4","dr_mutations_pyrazinamide","PRO",0,"SAMN02403623","SRR1175469_SRR1175521_SRR1175517_SRR1175511","lineage4.8","za","South Africa","pnca_p.ser59pro","A","-","SER","SA59","pnca_complex.pdb"
|
|
"S59P","L4","PZA","S","S59",59,"P",NA,"MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",11.829,-1.097,-0.594,3.6058,-1.13,-0.16,62,80,-0.671,7,7,38,0.245161290322581,"loop",0.533333333333333,3.86,0.0004312203536006,58.3312262958281,1393450.94022764,Inf,23.547488635408,0,0,0,0,0,0,0,0,0,4,2,2,0,0,0,0,0,-6,0,-4,-2,-2,0,-4,-6,-0.277862208713272,-0.153488372093023,0.131331084870956,-0.192668371696505,-0.0418848167539267,0.652631578947368,-0.552718286655684,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.779,-0.615,"8:7","148/150","T:G:A:S:Q:H:E:K:R:L:V",14.1472939191327,0.915018435775139,132.57606067652,0.106710773022978,4.17896182039693,NA,1.7659011066874,2.48532104922106e-05,4.60461750194108,5.71767556863798,Inf,1.21868387173808e-06,"lineage4","dr_mutations_pyrazinamide","PRO",0,"SAMN02586039","SRR1172945_SRR1196498_SRR1184341_SRR1173088","lineage4.8","za","South Africa","pnca_p.ser59pro","A","-","SER","SA59","pnca_complex.pdb"
|
|
"S59P","L4","PZA","S","S59",59,"P",NA,"MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",11.829,-1.097,-0.594,3.6058,-1.13,-0.16,62,80,-0.671,7,7,38,0.245161290322581,"loop",0.533333333333333,3.86,0.0004312203536006,58.3312262958281,1393450.94022764,Inf,23.547488635408,0,0,0,0,0,0,0,0,0,4,2,2,0,0,0,0,0,-6,0,-4,-2,-2,0,-4,-6,-0.277862208713272,-0.153488372093023,0.131331084870956,-0.192668371696505,-0.0418848167539267,0.652631578947368,-0.552718286655684,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.779,-0.615,"8:7","148/150","T:G:A:S:Q:H:E:K:R:L:V",14.1472939191327,0.915018435775139,132.57606067652,0.106710773022978,4.17896182039693,NA,1.7659011066874,2.48532104922106e-05,4.60461750194108,5.71767556863798,Inf,1.21868387173808e-06,"lineage4","dr_mutations_pyrazinamide","PRO",0,"SAMN01828247","SRR833005_SRR833093_SRR833047_SRR833108_SRR833178_SRR833004","lineage4.8","za","South Africa","pnca_p.ser59pro","A","-","SER","SA59","pnca_complex.pdb"
|
|
"S59P","L4","PZA","S","S59",59,"P",NA,"MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",11.829,-1.097,-0.594,3.6058,-1.13,-0.16,62,80,-0.671,7,7,38,0.245161290322581,"loop",0.533333333333333,3.86,0.0004312203536006,58.3312262958281,1393450.94022764,Inf,23.547488635408,0,0,0,0,0,0,0,0,0,4,2,2,0,0,0,0,0,-6,0,-4,-2,-2,0,-4,-6,-0.277862208713272,-0.153488372093023,0.131331084870956,-0.192668371696505,-0.0418848167539267,0.652631578947368,-0.552718286655684,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.779,-0.615,"8:7","148/150","T:G:A:S:Q:H:E:K:R:L:V",14.1472939191327,0.915018435775139,132.57606067652,0.106710773022978,4.17896182039693,NA,1.7659011066874,2.48532104922106e-05,4.60461750194108,5.71767556863798,Inf,1.21868387173808e-06,"lineage4","dr_mutations_pyrazinamide","PRO",0,"SAMN02586007","SRR1173523_SRR1173252_SRR1196505_SRR1184362","lineage4.8","za","South Africa","pnca_p.ser59pro","A","-","SER","SA59","pnca_complex.pdb"
|
|
"S59P","L4","PZA","S","S59",59,"P",NA,"MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",11.829,-1.097,-0.594,3.6058,-1.13,-0.16,62,80,-0.671,7,7,38,0.245161290322581,"loop",0.533333333333333,3.86,0.0004312203536006,58.3312262958281,1393450.94022764,Inf,23.547488635408,0,0,0,0,0,0,0,0,0,4,2,2,0,0,0,0,0,-6,0,-4,-2,-2,0,-4,-6,-0.277862208713272,-0.153488372093023,0.131331084870956,-0.192668371696505,-0.0418848167539267,0.652631578947368,-0.552718286655684,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.779,-0.615,"8:7","148/150","T:G:A:S:Q:H:E:K:R:L:V",14.1472939191327,0.915018435775139,132.57606067652,0.106710773022978,4.17896182039693,NA,1.7659011066874,2.48532104922106e-05,4.60461750194108,5.71767556863798,Inf,1.21868387173808e-06,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR2516068","ERR2516068","lineage4.8","za","South Africa","pnca_p.ser59pro","A","-","SER","SA59","pnca_complex.pdb"
|
|
"S59P","L4","PZA","S","S59",59,"P",NA,"MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",11.829,-1.097,-0.594,3.6058,-1.13,-0.16,62,80,-0.671,7,7,38,0.245161290322581,"loop",0.533333333333333,3.86,0.0004312203536006,58.3312262958281,1393450.94022764,Inf,23.547488635408,0,0,0,0,0,0,0,0,0,4,2,2,0,0,0,0,0,-6,0,-4,-2,-2,0,-4,-6,-0.277862208713272,-0.153488372093023,0.131331084870956,-0.192668371696505,-0.0418848167539267,0.652631578947368,-0.552718286655684,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.779,-0.615,"8:7","148/150","T:G:A:S:Q:H:E:K:R:L:V",14.1472939191327,0.915018435775139,132.57606067652,0.106710773022978,4.17896182039693,NA,1.7659011066874,2.48532104922106e-05,4.60461750194108,5.71767556863798,Inf,1.21868387173808e-06,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR2707172","ERR2707172","lineage4.3.4.2","cd","Democratic Republic of Congo","pnca_p.ser59pro","A","-","SER","SA59","pnca_complex.pdb"
|
|
"S59P","L2","PZA","S","S59",59,"P",NA,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",11.829,-1.097,-0.594,3.6058,-1.13,-0.16,62,80,-0.671,7,7,38,0.245161290322581,"loop",0.533333333333333,3.86,0.0004312203536006,58.3312262958281,1393450.94022764,Inf,23.547488635408,0,0,0,0,0,0,0,0,0,4,2,2,0,0,0,0,0,-6,0,-4,-2,-2,0,-4,-6,-0.277862208713272,-0.153488372093023,0.131331084870956,-0.192668371696505,-0.0418848167539267,0.652631578947368,-0.552718286655684,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.779,-0.615,"8:7","148/150","T:G:A:S:Q:H:E:K:R:L:V",14.1472939191327,0.915018435775139,132.57606067652,0.106710773022978,4.17896182039693,NA,1.7659011066874,2.48532104922106e-05,4.60461750194108,5.71767556863798,Inf,1.21868387173808e-06,"lineage2","dr_mutations_pyrazinamide","PRO",0,"SRR5266559","SRR5266559","lineage2.2.1","ru","Russia","pnca_p.ser59pro","A","-","SER","SA59","pnca_complex.pdb"
|
|
"S59P","L4","PZA","S","S59",59,"P",NA,"MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",11.829,-1.097,-0.594,3.6058,-1.13,-0.16,62,80,-0.671,7,7,38,0.245161290322581,"loop",0.533333333333333,3.86,0.0004312203536006,58.3312262958281,1393450.94022764,Inf,23.547488635408,0,0,0,0,0,0,0,0,0,4,2,2,0,0,0,0,0,-6,0,-4,-2,-2,0,-4,-6,-0.277862208713272,-0.153488372093023,0.131331084870956,-0.192668371696505,-0.0418848167539267,0.652631578947368,-0.552718286655684,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.779,-0.615,"8:7","148/150","T:G:A:S:Q:H:E:K:R:L:V",14.1472939191327,0.915018435775139,132.57606067652,0.106710773022978,4.17896182039693,NA,1.7659011066874,2.48532104922106e-05,4.60461750194108,5.71767556863798,Inf,1.21868387173808e-06,"lineage4","dr_mutations_pyrazinamide","PRO",0,"SAMN02403612","SRR1174827_SRR1169081_SRR1165666_SRR1167346","lineage4.8","za","South Africa","pnca_p.ser59pro","A","-","SER","SA59","pnca_complex.pdb"
|
|
"S59P","L4","PZA","S","S59",59,"P",NA,"MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",11.829,-1.097,-0.594,3.6058,-1.13,-0.16,62,80,-0.671,7,7,38,0.245161290322581,"loop",0.533333333333333,3.86,0.0004312203536006,58.3312262958281,1393450.94022764,Inf,23.547488635408,0,0,0,0,0,0,0,0,0,4,2,2,0,0,0,0,0,-6,0,-4,-2,-2,0,-4,-6,-0.277862208713272,-0.153488372093023,0.131331084870956,-0.192668371696505,-0.0418848167539267,0.652631578947368,-0.552718286655684,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.779,-0.615,"8:7","148/150","T:G:A:S:Q:H:E:K:R:L:V",14.1472939191327,0.915018435775139,132.57606067652,0.106710773022978,4.17896182039693,NA,1.7659011066874,2.48532104922106e-05,4.60461750194108,5.71767556863798,Inf,1.21868387173808e-06,"lineage4","dr_mutations_pyrazinamide","PRO",0,"SRR7517735","SRR7517735","lineage4.3.4.2","ch","Switzerland","pnca_p.ser59pro","A","-","SER","SA59","pnca_complex.pdb"
|
|
"S59Y","L2","PZA","S","S59",59,"Y",1,"Pre-XDR","OM","hydrophilic","hydrophobic","neutral","neutral","polar","polar",11.829,-0.553,-0.542,0.447426,-0.986,-0.66,58,75,-0.671,7,7,38,0.245161290322581,"loop",0.533333333333333,3.86,7.18700589334483e-05,9.70142977291842,188179.926264634,Inf,0.763784339928386,-22,-2,0,0,-2,0,0,0,0,2,0,2,0,0,0,0,0,-1,0,-1,0,0,0,-2,-2,-0.140070921985815,-0.140051679586563,0.0162962288478209,-0.168115942028985,-0.172774869109948,0.610526315789474,-0.552718286655684,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.779,-0.615,"8:7","148/150","T:G:A:S:Q:H:E:K:R:L:V",12.1451538387264,0.919026337424234,119.468044436232,0.101660271548256,5.0115366606273e-06,NA,0.986835744238421,0.170978870202674,0.767057556984365,0.124324963210678,Inf,0.382146811758261,"lineage2","other_mutations_pyrazinamide","TYR",0,"SAMN10961392","SRR8651662","lineage2.2.1","cn","China:Wenzhou","pnca_p.ser59tyr","A","-","SER","SA59","pnca_complex.pdb"
|
|
"G60D","L4","PZA","G","G60",60,"D",0,"Sensitive","OM","hydrophobic","hydrophilic","neutral","acidic","non-polar","neg",14.904,0.52,-0.161,-2.08267,0.187,-0.13,-38,66,0.72,2,2,80,0.769230769230769,"loop",-0.633333333333333,3.26,7.18700589334483e-05,2.42412778478352,0.0001249735077034,0,1.03410070803344e-29,0,-8,0,0,-8,0,0,0,0,-4,0,0,-4,0,0,0,0,-1,0,-1,0,0,0,-1,-7,0.233183856502242,-0.0416020671834625,-0.400421056679228,0.157939189189189,-0.0340314136125654,-0.408602150537634,0.230769230769231,"Stabilising","Destabilising","Stabilising","Stabilising","Destabilising","neutral",0.389,0.842,"4:2","148/150","H:E:Q:N:L:V:K:I:T:A:S:G:P:D",-8.98740878149641,0.940032862253634,119.468044435492,-0.0752285585987745,NA,4692673.51081424,0.384555509373631,1,0,0,188.544222231268,0.999999999999997,"lineage4","other_mutations_pyrazinamide","ASP",0,"ERS2286463","ERR2503536","lineage4.8","fi","Finland","pnca_p.gly60asp","A","S","GLY","GA60","pnca_complex.pdb"
|
|
"G60D","L4","PZA","G","G60",60,"D",NA,"Sensitive","OM","hydrophobic","hydrophilic","neutral","acidic","non-polar","neg",14.904,0.52,-0.161,-2.08267,0.187,-0.13,-38,66,0.72,2,2,80,0.769230769230769,"loop",-0.633333333333333,3.26,7.18700589334483e-05,2.42412778478352,0.0001249735077034,0,1.03410070803344e-29,0,-8,0,0,-8,0,0,0,0,-4,0,0,-4,0,0,0,0,-1,0,-1,0,0,0,-1,-7,0.233183856502242,-0.0416020671834625,-0.400421056679228,0.157939189189189,-0.0340314136125654,-0.408602150537634,0.230769230769231,"Stabilising","Destabilising","Stabilising","Stabilising","Destabilising","neutral",0.389,0.842,"4:2","148/150","H:E:Q:N:L:V:K:I:T:A:S:G:P:D",-8.98740878149641,0.940032862253634,119.468044435492,-0.0752285585987745,NA,4692673.51081424,0.384555509373631,1,0,0,188.544222231268,0.999999999999997,"lineage4","other_mutations_pyrazinamide","ASP",0,"ERR1023304","ERR1023304","lineage4.8","","","pnca_p.gly60asp","A","S","GLY","GA60","pnca_complex.pdb"
|
|
"G60D","L4","PZA","G","G60",60,"D",NA,"Pre-MDR","OM","hydrophobic","hydrophilic","neutral","acidic","non-polar","neg",14.904,0.52,-0.161,-2.08267,0.187,-0.13,-38,66,0.72,2,2,80,0.769230769230769,"loop",-0.633333333333333,3.26,7.18700589334483e-05,2.42412778478352,0.0001249735077034,0,1.03410070803344e-29,0,-8,0,0,-8,0,0,0,0,-4,0,0,-4,0,0,0,0,-1,0,-1,0,0,0,-1,-7,0.233183856502242,-0.0416020671834625,-0.400421056679228,0.157939189189189,-0.0340314136125654,-0.408602150537634,0.230769230769231,"Stabilising","Destabilising","Stabilising","Stabilising","Destabilising","neutral",0.389,0.842,"4:2","148/150","H:E:Q:N:L:V:K:I:T:A:S:G:P:D",-8.98740878149641,0.940032862253634,119.468044435492,-0.0752285585987745,NA,4692673.51081424,0.384555509373631,1,0,0,188.544222231268,0.999999999999997,"lineage4","other_mutations_pyrazinamide","ASP",0,"SRR6325448","SRR6325448","lineage4.3","us","","pnca_p.gly60asp","A","S","GLY","GA60","pnca_complex.pdb"
|
|
"G60D","L4","PZA","G","G60",60,"D",NA,"Sensitive","OM","hydrophobic","hydrophilic","neutral","acidic","non-polar","neg",14.904,0.52,-0.161,-2.08267,0.187,-0.13,-38,66,0.72,2,2,80,0.769230769230769,"loop",-0.633333333333333,3.26,7.18700589334483e-05,2.42412778478352,0.0001249735077034,0,1.03410070803344e-29,0,-8,0,0,-8,0,0,0,0,-4,0,0,-4,0,0,0,0,-1,0,-1,0,0,0,-1,-7,0.233183856502242,-0.0416020671834625,-0.400421056679228,0.157939189189189,-0.0340314136125654,-0.408602150537634,0.230769230769231,"Stabilising","Destabilising","Stabilising","Stabilising","Destabilising","neutral",0.389,0.842,"4:2","148/150","H:E:Q:N:L:V:K:I:T:A:S:G:P:D",-8.98740878149641,0.940032862253634,119.468044435492,-0.0752285585987745,NA,4692673.51081424,0.384555509373631,1,0,0,188.544222231268,0.999999999999997,"lineage4","other_mutations_pyrazinamide","ASP",0,"ERR1465914","ERR1465914","lineage4.8","ch","Switzerland","pnca_p.gly60asp","A","S","GLY","GA60","pnca_complex.pdb"
|
|
"G60D","L4","PZA","G","G60",60,"D",NA,"Sensitive","OM","hydrophobic","hydrophilic","neutral","acidic","non-polar","neg",14.904,0.52,-0.161,-2.08267,0.187,-0.13,-38,66,0.72,2,2,80,0.769230769230769,"loop",-0.633333333333333,3.26,7.18700589334483e-05,2.42412778478352,0.0001249735077034,0,1.03410070803344e-29,0,-8,0,0,-8,0,0,0,0,-4,0,0,-4,0,0,0,0,-1,0,-1,0,0,0,-1,-7,0.233183856502242,-0.0416020671834625,-0.400421056679228,0.157939189189189,-0.0340314136125654,-0.408602150537634,0.230769230769231,"Stabilising","Destabilising","Stabilising","Stabilising","Destabilising","neutral",0.389,0.842,"4:2","148/150","H:E:Q:N:L:V:K:I:T:A:S:G:P:D",-8.98740878149641,0.940032862253634,119.468044435492,-0.0752285585987745,NA,4692673.51081424,0.384555509373631,1,0,0,188.544222231268,0.999999999999997,"lineage4","other_mutations_pyrazinamide","ASP",0,"ERR1023391","ERR1023391","lineage4.8","","","pnca_p.gly60asp","A","S","GLY","GA60","pnca_complex.pdb"
|
|
"G60D","L6","PZA","G","G60",60,"D",NA,"Sensitive","OM","hydrophobic","hydrophilic","neutral","acidic","non-polar","neg",14.904,0.52,-0.161,-2.08267,0.187,-0.13,-38,66,0.72,2,2,80,0.769230769230769,"loop",-0.633333333333333,3.26,7.18700589334483e-05,2.42412778478352,0.0001249735077034,0,1.03410070803344e-29,0,-8,0,0,-8,0,0,0,0,-4,0,0,-4,0,0,0,0,-1,0,-1,0,0,0,-1,-7,0.233183856502242,-0.0416020671834625,-0.400421056679228,0.157939189189189,-0.0340314136125654,-0.408602150537634,0.230769230769231,"Stabilising","Destabilising","Stabilising","Stabilising","Destabilising","neutral",0.389,0.842,"4:2","148/150","H:E:Q:N:L:V:K:I:T:A:S:G:P:D",-8.98740878149641,0.940032862253634,119.468044435492,-0.0752285585987745,NA,4692673.51081424,0.384555509373631,1,0,0,188.544222231268,0.999999999999997,"lineage6","other_mutations_pyrazinamide","ASP",0,"ERR779852","ERR779852","lineage6","","","pnca_p.gly60asp","A","S","GLY","GA60","pnca_complex.pdb"
|
|
"G60D","L3;L4","PZA","G","G60",60,"D",NA,"Pre-MDR","OM","hydrophobic","hydrophilic","neutral","acidic","non-polar","neg",14.904,0.52,-0.161,-2.08267,0.187,-0.13,-38,66,0.72,2,2,80,0.769230769230769,"loop",-0.633333333333333,3.26,7.18700589334483e-05,2.42412778478352,0.0001249735077034,0,1.03410070803344e-29,0,-8,0,0,-8,0,0,0,0,-4,0,0,-4,0,0,0,0,-1,0,-1,0,0,0,-1,-7,0.233183856502242,-0.0416020671834625,-0.400421056679228,0.157939189189189,-0.0340314136125654,-0.408602150537634,0.230769230769231,"Stabilising","Destabilising","Stabilising","Stabilising","Destabilising","neutral",0.389,0.842,"4:2","148/150","H:E:Q:N:L:V:K:I:T:A:S:G:P:D",-8.98740878149641,0.940032862253634,119.468044435492,-0.0752285585987745,NA,4692673.51081424,0.384555509373631,1,0,0,188.544222231268,0.999999999999997,"lineage3;lineage4","other_mutations_pyrazinamide","ASP",0,"SRR6325444","SRR6325444","lineage4.3;lineage3","us","","pnca_p.gly60asp","A","S","GLY","GA60","pnca_complex.pdb"
|
|
"G60D","L1","PZA","G","G60",60,"D",NA,"Pre-MDR","OM","hydrophobic","hydrophilic","neutral","acidic","non-polar","neg",14.904,0.52,-0.161,-2.08267,0.187,-0.13,-38,66,0.72,2,2,80,0.769230769230769,"loop",-0.633333333333333,3.26,7.18700589334483e-05,2.42412778478352,0.0001249735077034,0,1.03410070803344e-29,0,-8,0,0,-8,0,0,0,0,-4,0,0,-4,0,0,0,0,-1,0,-1,0,0,0,-1,-7,0.233183856502242,-0.0416020671834625,-0.400421056679228,0.157939189189189,-0.0340314136125654,-0.408602150537634,0.230769230769231,"Stabilising","Destabilising","Stabilising","Stabilising","Destabilising","neutral",0.389,0.842,"4:2","148/150","H:E:Q:N:L:V:K:I:T:A:S:G:P:D",-8.98740878149641,0.940032862253634,119.468044435492,-0.0752285585987745,NA,4692673.51081424,0.384555509373631,1,0,0,188.544222231268,0.999999999999997,"lineage1","other_mutations_pyrazinamide","ASP",0,"ERR702404","ERR702404","lineage1","gh","Ghana","pnca_p.gly60asp","A","S","GLY","GA60","pnca_complex.pdb"
|
|
"T61P","L4","PZA","T","T61",61,"P",NA,"MDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",14.618,-0.472,-0.204,1.58134,-0.158,0.02,-13,57,1.323,1,1,130,0.755813953488372,"loop",-0.9,3.48,7.18700589334483e-05,2.42412778478352,0.0001249735077034,0,1.03410070803344e-29,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,2,-2,0,0,0,0,-2,-0.119554204660588,-0.0527131782945736,0.0575958449580781,-0.0269394714407502,0.0112359550561797,-0.139784946236559,0.424038461538462,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","neutral",0.842,1.712,"2:1","124/150","R:K:N:L:V:Q:H:E:D:P:T:A:G:S",-8.98740878149644,0.940032862253633,119.468044435491,-0.0752285585987752,NA,4692673.51081345,0.384555509373631,1,0,0,188.544222231268,0.999999999999997,"lineage4","dr_mutations_pyrazinamide","PRO",0,"SAMN02403629","SRR1175497_SRR1175498_SRR1175480_SRR1175526","lineage4.1.2.1","za","South Africa","pnca_p.thr61pro","A","S","THR","TA61","pnca_complex.pdb"
|
|
"T61P","L2","PZA","T","T61",61,"P",NA,"MDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",14.618,-0.472,-0.204,1.58134,-0.158,0.02,-13,57,1.323,1,1,130,0.755813953488372,"loop",-0.9,3.48,7.18700589334483e-05,2.42412778478352,0.0001249735077034,0,1.03410070803344e-29,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,2,-2,0,0,0,0,-2,-0.119554204660588,-0.0527131782945736,0.0575958449580781,-0.0269394714407502,0.0112359550561797,-0.139784946236559,0.424038461538462,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","neutral",0.842,1.712,"2:1","124/150","R:K:N:L:V:Q:H:E:D:P:T:A:G:S",-8.98740878149644,0.940032862253633,119.468044435491,-0.0752285585987752,NA,4692673.51081345,0.384555509373631,1,0,0,188.544222231268,0.999999999999997,"lineage2","dr_mutations_pyrazinamide","PRO",0,"SAMN07236400,SRR5709878","SRR5709878","lineage2.2.1","th","Thailand","pnca_p.thr61pro","A","S","THR","TA61","pnca_complex.pdb"
|
|
"T61P","L4","PZA","T","T61",61,"P",NA,"MDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",14.618,-0.472,-0.204,1.58134,-0.158,0.02,-13,57,1.323,1,1,130,0.755813953488372,"loop",-0.9,3.48,7.18700589334483e-05,2.42412778478352,0.0001249735077034,0,1.03410070803344e-29,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,2,-2,0,0,0,0,-2,-0.119554204660588,-0.0527131782945736,0.0575958449580781,-0.0269394714407502,0.0112359550561797,-0.139784946236559,0.424038461538462,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","neutral",0.842,1.712,"2:1","124/150","R:K:N:L:V:Q:H:E:D:P:T:A:G:S",-8.98740878149644,0.940032862253633,119.468044435491,-0.0752285585987752,NA,4692673.51081345,0.384555509373631,1,0,0,188.544222231268,0.999999999999997,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR2706913","ERR2706913","lineage4.9","cd","Democratic Republic of Congo","pnca_p.thr61pro","A","S","THR","TA61","pnca_complex.pdb"
|
|
"T61P","L3","PZA","T","T61",61,"P",0,"MDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",14.618,-0.472,-0.204,1.58134,-0.158,0.02,-13,57,1.323,1,1,130,0.755813953488372,"loop",-0.9,3.48,7.18700589334483e-05,2.42412778478352,0.0001249735077034,0,1.03410070803344e-29,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,2,-2,0,0,0,0,-2,-0.119554204660588,-0.0527131782945736,0.0575958449580781,-0.0269394714407502,0.0112359550561797,-0.139784946236559,0.424038461538462,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","neutral",0.842,1.712,"2:1","124/150","R:K:N:L:V:Q:H:E:D:P:T:A:G:S",-8.98740878149644,0.940032862253633,119.468044435491,-0.0752285585987752,NA,4692673.51081345,0.384555509373631,1,0,0,188.544222231268,0.999999999999997,"lineage3","dr_mutations_pyrazinamide","PRO",0,"ERR2510424","ERR2510424","lineage3","pk","Pakistan","pnca_p.thr61pro","A","S","THR","TA61","pnca_complex.pdb"
|
|
"T61P","L2","PZA","T","T61",61,"P",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",14.618,-0.472,-0.204,1.58134,-0.158,0.02,-13,57,1.323,1,1,130,0.755813953488372,"loop",-0.9,3.48,7.18700589334483e-05,2.42412778478352,0.0001249735077034,0,1.03410070803344e-29,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,2,-2,0,0,0,0,-2,-0.119554204660588,-0.0527131782945736,0.0575958449580781,-0.0269394714407502,0.0112359550561797,-0.139784946236559,0.424038461538462,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","neutral",0.842,1.712,"2:1","124/150","R:K:N:L:V:Q:H:E:D:P:T:A:G:S",-8.98740878149644,0.940032862253633,119.468044435491,-0.0752285585987752,NA,4692673.51081345,0.384555509373631,1,0,0,188.544222231268,0.999999999999997,"lineage2","dr_mutations_pyrazinamide","PRO",0,"BGI_SH287,SRR671812","SRR671812","lineage2.2.1","cn","China","pnca_p.thr61pro","A","S","THR","TA61","pnca_complex.pdb"
|
|
"T61P","L4","PZA","T","T61",61,"P",NA,"MDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",14.618,-0.472,-0.204,1.58134,-0.158,0.02,-13,57,1.323,1,1,130,0.755813953488372,"loop",-0.9,3.48,7.18700589334483e-05,2.42412778478352,0.0001249735077034,0,1.03410070803344e-29,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,2,-2,0,0,0,0,-2,-0.119554204660588,-0.0527131782945736,0.0575958449580781,-0.0269394714407502,0.0112359550561797,-0.139784946236559,0.424038461538462,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","neutral",0.842,1.712,"2:1","124/150","R:K:N:L:V:Q:H:E:D:P:T:A:G:S",-8.98740878149644,0.940032862253633,119.468044435491,-0.0752285585987752,NA,4692673.51081345,0.384555509373631,1,0,0,188.544222231268,0.999999999999997,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR1035155","ERR1035155","lineage4.2.2","sa","Saudi Arabia","pnca_p.thr61pro","A","S","THR","TA61","pnca_complex.pdb"
|
|
"T61P","L4","PZA","T","T61",61,"P",NA,"MDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",14.618,-0.472,-0.204,1.58134,-0.158,0.02,-13,57,1.323,1,1,130,0.755813953488372,"loop",-0.9,3.48,7.18700589334483e-05,2.42412778478352,0.0001249735077034,0,1.03410070803344e-29,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,2,-2,0,0,0,0,-2,-0.119554204660588,-0.0527131782945736,0.0575958449580781,-0.0269394714407502,0.0112359550561797,-0.139784946236559,0.424038461538462,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","neutral",0.842,1.712,"2:1","124/150","R:K:N:L:V:Q:H:E:D:P:T:A:G:S",-8.98740878149644,0.940032862253633,119.468044435491,-0.0752285585987752,NA,4692673.51081345,0.384555509373631,1,0,0,188.544222231268,0.999999999999997,"lineage4","dr_mutations_pyrazinamide","PRO",0,"SAMN02403630","SRR1175522_SRR1175483_SRR1175503_SRR1175488","lineage4.1.2.1","za","South Africa","pnca_p.thr61pro","A","S","THR","TA61","pnca_complex.pdb"
|
|
"T61R","L1","PZA","T","T61",61,"R",NA,"Pre-MDR","OM","hydrophobic","hydrophilic","neutral","basic","polar","pos",14.618,-0.01,0.174,-0.362941,-0.011,-0.02,-37,66,1.323,1,1,130,0.755813953488372,"loop",-0.9,3.48,NA,NA,NA,NA,NA,-8,-4,0,0,-4,0,0,0,0,0,0,0,0,0,0,0,0,-1,0,-1,-1,0,0,0,0,-0.0025329280648429,0.147959183673469,-0.0697802430208413,-0.00187553282182438,-0.0052356020942408,-0.397849462365591,0.424038461538462,"Destabilising","Stabilising","Stabilising","Destabilising","Destabilising","neutral",0.842,1.712,"2:1","124/150","R:K:N:L:V:Q:H:E:D:P:T:A:G:S",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage1","other_mutations_pyrazinamide","ARG",0,"ERR702404","ERR702404","lineage1","gh","Ghana","pnca_p.thr61arg","A","S","THR","TA61","pnca_complex.pdb"
|
|
"P62L","L4","PZA","P","P62",62,"L",1,"MDR","DM","hydrophilic","hydrophobic","non-polar","non-polar","non-polar","non-polar",11.121,-0.276,-0.504,1.77658,-1.127,-0.59,54,75,-0.599,7,7,34,0.213836477987421,"loop",-1.93333333333333,3.99,0.0007905706482679,48.6872097931617,48.6872048041474,48.6746878162623,37.2619168572472,0,-2,0,0,-2,0,0,0,0,0,0,0,0,0,0,0,0,-1,-2,-7,1,2,0,4,2,-0.0699088145896656,-0.130232558139535,0.0647069107438137,-0.192156862745098,-0.154450261780105,0.568421052631579,-0.49341021416804,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.779,-0.485,"8:7","125/150","I:V:P:A:E",3.88541626053988,0.0002118075877292,1.0488367141091,3.70450062271154,9.31977387255173,893.783372292271,1.68741488635211,1.95392414212297e-07,6.70909230105579,6.91781679568266,2088.84994220519,1.03281930722422e-09,"lineage4","dr_mutations_pyrazinamide","LEU",0,"ERR1034715","ERR1034715","lineage4.1.2.1","pe","Peru","pnca_p.pro62leu","A","-","PRO","PA62","pnca_complex.pdb"
|
|
"P62L","L3","PZA","P","P62",62,"L",1,"Pre-XDR","DM","hydrophilic","hydrophobic","non-polar","non-polar","non-polar","non-polar",11.121,-0.276,-0.504,1.77658,-1.127,-0.59,54,75,-0.599,7,7,34,0.213836477987421,"loop",-1.93333333333333,3.99,0.0007905706482679,48.6872097931617,48.6872048041474,48.6746878162623,37.2619168572472,0,-2,0,0,-2,0,0,0,0,0,0,0,0,0,0,0,0,-1,-2,-7,1,2,0,4,2,-0.0699088145896656,-0.130232558139535,0.0647069107438137,-0.192156862745098,-0.154450261780105,0.568421052631579,-0.49341021416804,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.779,-0.485,"8:7","125/150","I:V:P:A:E",3.88541626053988,0.0002118075877292,1.0488367141091,3.70450062271154,9.31977387255173,893.783372292271,1.68741488635211,1.95392414212297e-07,6.70909230105579,6.91781679568266,2088.84994220519,1.03281930722422e-09,"lineage3","dr_mutations_pyrazinamide","LEU",0,"ERR2510284","ERR2510284","lineage3","pk","Pakistan","pnca_p.pro62leu","A","-","PRO","PA62","pnca_complex.pdb"
|
|
"P62L","L2","PZA","P","P62",62,"L",NA,"XDR","DM","hydrophilic","hydrophobic","non-polar","non-polar","non-polar","non-polar",11.121,-0.276,-0.504,1.77658,-1.127,-0.59,54,75,-0.599,7,7,34,0.213836477987421,"loop",-1.93333333333333,3.99,0.0007905706482679,48.6872097931617,48.6872048041474,48.6746878162623,37.2619168572472,0,-2,0,0,-2,0,0,0,0,0,0,0,0,0,0,0,0,-1,-2,-7,1,2,0,4,2,-0.0699088145896656,-0.130232558139535,0.0647069107438137,-0.192156862745098,-0.154450261780105,0.568421052631579,-0.49341021416804,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.779,-0.485,"8:7","125/150","I:V:P:A:E",3.88541626053988,0.0002118075877292,1.0488367141091,3.70450062271154,9.31977387255173,893.783372292271,1.68741488635211,1.95392414212297e-07,6.70909230105579,6.91781679568266,2088.84994220519,1.03281930722422e-09,"lineage2","dr_mutations_pyrazinamide","LEU",0,"SAMN07236532,SRR5709765","SRR5709765","lineage2.2.1","th","Thailand","pnca_p.pro62leu","A","-","PRO","PA62","pnca_complex.pdb"
|
|
"P62L","L2","PZA","P","P62",62,"L",0,"MDR","DM","hydrophilic","hydrophobic","non-polar","non-polar","non-polar","non-polar",11.121,-0.276,-0.504,1.77658,-1.127,-0.59,54,75,-0.599,7,7,34,0.213836477987421,"loop",-1.93333333333333,3.99,0.0007905706482679,48.6872097931617,48.6872048041474,48.6746878162623,37.2619168572472,0,-2,0,0,-2,0,0,0,0,0,0,0,0,0,0,0,0,-1,-2,-7,1,2,0,4,2,-0.0699088145896656,-0.130232558139535,0.0647069107438137,-0.192156862745098,-0.154450261780105,0.568421052631579,-0.49341021416804,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.779,-0.485,"8:7","125/150","I:V:P:A:E",3.88541626053988,0.0002118075877292,1.0488367141091,3.70450062271154,9.31977387255173,893.783372292271,1.68741488635211,1.95392414212297e-07,6.70909230105579,6.91781679568266,2088.84994220519,1.03281930722422e-09,"lineage2","dr_mutations_pyrazinamide","LEU",0,"MDR_15130","SRR6824561","lineage2.2.1","cn","China: Zhoucun District, Zibo City, Shandong Province","pnca_p.pro62leu","A","-","PRO","PA62","pnca_complex.pdb"
|
|
"P62L","L2","PZA","P","P62",62,"L",NA,"MDR","DM","hydrophilic","hydrophobic","non-polar","non-polar","non-polar","non-polar",11.121,-0.276,-0.504,1.77658,-1.127,-0.59,54,75,-0.599,7,7,34,0.213836477987421,"loop",-1.93333333333333,3.99,0.0007905706482679,48.6872097931617,48.6872048041474,48.6746878162623,37.2619168572472,0,-2,0,0,-2,0,0,0,0,0,0,0,0,0,0,0,0,-1,-2,-7,1,2,0,4,2,-0.0699088145896656,-0.130232558139535,0.0647069107438137,-0.192156862745098,-0.154450261780105,0.568421052631579,-0.49341021416804,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.779,-0.485,"8:7","125/150","I:V:P:A:E",3.88541626053988,0.0002118075877292,1.0488367141091,3.70450062271154,9.31977387255173,893.783372292271,1.68741488635211,1.95392414212297e-07,6.70909230105579,6.91781679568266,2088.84994220519,1.03281930722422e-09,"lineage2","dr_mutations_pyrazinamide","LEU",0,"SRS797337","SRR1723870","lineage2.2.1","cn","China:Henan","pnca_p.pro62leu","A","-","PRO","PA62","pnca_complex.pdb"
|
|
"P62L","L4","PZA","P","P62",62,"L",1,"Pre-XDR","DM","hydrophilic","hydrophobic","non-polar","non-polar","non-polar","non-polar",11.121,-0.276,-0.504,1.77658,-1.127,-0.59,54,75,-0.599,7,7,34,0.213836477987421,"loop",-1.93333333333333,3.99,0.0007905706482679,48.6872097931617,48.6872048041474,48.6746878162623,37.2619168572472,0,-2,0,0,-2,0,0,0,0,0,0,0,0,0,0,0,0,-1,-2,-7,1,2,0,4,2,-0.0699088145896656,-0.130232558139535,0.0647069107438137,-0.192156862745098,-0.154450261780105,0.568421052631579,-0.49341021416804,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.779,-0.485,"8:7","125/150","I:V:P:A:E",3.88541626053988,0.0002118075877292,1.0488367141091,3.70450062271154,9.31977387255173,893.783372292271,1.68741488635211,1.95392414212297e-07,6.70909230105579,6.91781679568266,2088.84994220519,1.03281930722422e-09,"lineage4","dr_mutations_pyrazinamide","LEU",0,"ERR2510616","ERR2510616","lineage4.2.2","pk","Pakistan","pnca_p.pro62leu","A","-","PRO","PA62","pnca_complex.pdb"
|
|
"P62L","L2","PZA","P","P62",62,"L",NA,"MDR","DM","hydrophilic","hydrophobic","non-polar","non-polar","non-polar","non-polar",11.121,-0.276,-0.504,1.77658,-1.127,-0.59,54,75,-0.599,7,7,34,0.213836477987421,"loop",-1.93333333333333,3.99,0.0007905706482679,48.6872097931617,48.6872048041474,48.6746878162623,37.2619168572472,0,-2,0,0,-2,0,0,0,0,0,0,0,0,0,0,0,0,-1,-2,-7,1,2,0,4,2,-0.0699088145896656,-0.130232558139535,0.0647069107438137,-0.192156862745098,-0.154450261780105,0.568421052631579,-0.49341021416804,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.779,-0.485,"8:7","125/150","I:V:P:A:E",3.88541626053988,0.0002118075877292,1.0488367141091,3.70450062271154,9.31977387255173,893.783372292271,1.68741488635211,1.95392414212297e-07,6.70909230105579,6.91781679568266,2088.84994220519,1.03281930722422e-09,"lineage2","dr_mutations_pyrazinamide","LEU",0,"BGI_N-xz06042,SRR671739","SRR671739","lineage2.2.1","cn","China","pnca_p.pro62leu","A","-","PRO","PA62","pnca_complex.pdb"
|
|
"P62L","L2","PZA","P","P62",62,"L",1,"MDR","DM","hydrophilic","hydrophobic","non-polar","non-polar","non-polar","non-polar",11.121,-0.276,-0.504,1.77658,-1.127,-0.59,54,75,-0.599,7,7,34,0.213836477987421,"loop",-1.93333333333333,3.99,0.0007905706482679,48.6872097931617,48.6872048041474,48.6746878162623,37.2619168572472,0,-2,0,0,-2,0,0,0,0,0,0,0,0,0,0,0,0,-1,-2,-7,1,2,0,4,2,-0.0699088145896656,-0.130232558139535,0.0647069107438137,-0.192156862745098,-0.154450261780105,0.568421052631579,-0.49341021416804,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.779,-0.485,"8:7","125/150","I:V:P:A:E",3.88541626053988,0.0002118075877292,1.0488367141091,3.70450062271154,9.31977387255173,893.783372292271,1.68741488635211,1.95392414212297e-07,6.70909230105579,6.91781679568266,2088.84994220519,1.03281930722422e-09,"lineage2","dr_mutations_pyrazinamide","LEU",0,"MDR_15129","SRR6824427","lineage2.2.1","cn","China: Zhoucun District, Zibo City, Shandong Province","pnca_p.pro62leu","A","-","PRO","PA62","pnca_complex.pdb"
|
|
"P62L","L4","PZA","P","P62",62,"L",1,"XDR","DM","hydrophilic","hydrophobic","non-polar","non-polar","non-polar","non-polar",11.121,-0.276,-0.504,1.77658,-1.127,-0.59,54,75,-0.599,7,7,34,0.213836477987421,"loop",-1.93333333333333,3.99,0.0007905706482679,48.6872097931617,48.6872048041474,48.6746878162623,37.2619168572472,0,-2,0,0,-2,0,0,0,0,0,0,0,0,0,0,0,0,-1,-2,-7,1,2,0,4,2,-0.0699088145896656,-0.130232558139535,0.0647069107438137,-0.192156862745098,-0.154450261780105,0.568421052631579,-0.49341021416804,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.779,-0.485,"8:7","125/150","I:V:P:A:E",3.88541626053988,0.0002118075877292,1.0488367141091,3.70450062271154,9.31977387255173,893.783372292271,1.68741488635211,1.95392414212297e-07,6.70909230105579,6.91781679568266,2088.84994220519,1.03281930722422e-09,"lineage4","dr_mutations_pyrazinamide","LEU",0,"8016","ERR3014593","lineage4.3.1","tn","Tunisia:Bizerte","pnca_p.pro62leu","A","-","PRO","PA62","pnca_complex.pdb"
|
|
"P62L","L2","PZA","P","P62",62,"L",1,"MDR","DM","hydrophilic","hydrophobic","non-polar","non-polar","non-polar","non-polar",11.121,-0.276,-0.504,1.77658,-1.127,-0.59,54,75,-0.599,7,7,34,0.213836477987421,"loop",-1.93333333333333,3.99,0.0007905706482679,48.6872097931617,48.6872048041474,48.6746878162623,37.2619168572472,0,-2,0,0,-2,0,0,0,0,0,0,0,0,0,0,0,0,-1,-2,-7,1,2,0,4,2,-0.0699088145896656,-0.130232558139535,0.0647069107438137,-0.192156862745098,-0.154450261780105,0.568421052631579,-0.49341021416804,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.779,-0.485,"8:7","125/150","I:V:P:A:E",3.88541626053988,0.0002118075877292,1.0488367141091,3.70450062271154,9.31977387255173,893.783372292271,1.68741488635211,1.95392414212297e-07,6.70909230105579,6.91781679568266,2088.84994220519,1.03281930722422e-09,"lineage2","dr_mutations_pyrazinamide","LEU",0,"ERR2516214","ERR2516214","lineage2.2.1","be","Belgium","pnca_p.pro62leu","A","-","PRO","PA62","pnca_complex.pdb"
|
|
"P62L","L4","PZA","P","P62",62,"L",NA,"MDR","DM","hydrophilic","hydrophobic","non-polar","non-polar","non-polar","non-polar",11.121,-0.276,-0.504,1.77658,-1.127,-0.59,54,75,-0.599,7,7,34,0.213836477987421,"loop",-1.93333333333333,3.99,0.0007905706482679,48.6872097931617,48.6872048041474,48.6746878162623,37.2619168572472,0,-2,0,0,-2,0,0,0,0,0,0,0,0,0,0,0,0,-1,-2,-7,1,2,0,4,2,-0.0699088145896656,-0.130232558139535,0.0647069107438137,-0.192156862745098,-0.154450261780105,0.568421052631579,-0.49341021416804,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.779,-0.485,"8:7","125/150","I:V:P:A:E",3.88541626053988,0.0002118075877292,1.0488367141091,3.70450062271154,9.31977387255173,893.783372292271,1.68741488635211,1.95392414212297e-07,6.70909230105579,6.91781679568266,2088.84994220519,1.03281930722422e-09,"lineage4","dr_mutations_pyrazinamide","LEU",0,"SAMN02567729","SRR1166319","lineage4.2.1","ro","Romania","pnca_p.pro62leu","A","-","PRO","PA62","pnca_complex.pdb"
|
|
"P62L","L4","PZA","P","P62",62,"L",NA,"MDR","DM","hydrophilic","hydrophobic","non-polar","non-polar","non-polar","non-polar",11.121,-0.276,-0.504,1.77658,-1.127,-0.59,54,75,-0.599,7,7,34,0.213836477987421,"loop",-1.93333333333333,3.99,0.0007905706482679,48.6872097931617,48.6872048041474,48.6746878162623,37.2619168572472,0,-2,0,0,-2,0,0,0,0,0,0,0,0,0,0,0,0,-1,-2,-7,1,2,0,4,2,-0.0699088145896656,-0.130232558139535,0.0647069107438137,-0.192156862745098,-0.154450261780105,0.568421052631579,-0.49341021416804,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.779,-0.485,"8:7","125/150","I:V:P:A:E",3.88541626053988,0.0002118075877292,1.0488367141091,3.70450062271154,9.31977387255173,893.783372292271,1.68741488635211,1.95392414212297e-07,6.70909230105579,6.91781679568266,2088.84994220519,1.03281930722422e-09,"lineage4","dr_mutations_pyrazinamide","LEU",0,"SAMN02414956","SRR1162872_SRR1165509_SRR1165564_SRR1163052","lineage4.8","se","Sweden","pnca_p.pro62leu","A","-","PRO","PA62","pnca_complex.pdb"
|
|
"P62L","L4","PZA","P","P62",62,"L",NA,"MDR","DM","hydrophilic","hydrophobic","non-polar","non-polar","non-polar","non-polar",11.121,-0.276,-0.504,1.77658,-1.127,-0.59,54,75,-0.599,7,7,34,0.213836477987421,"loop",-1.93333333333333,3.99,0.0007905706482679,48.6872097931617,48.6872048041474,48.6746878162623,37.2619168572472,0,-2,0,0,-2,0,0,0,0,0,0,0,0,0,0,0,0,-1,-2,-7,1,2,0,4,2,-0.0699088145896656,-0.130232558139535,0.0647069107438137,-0.192156862745098,-0.154450261780105,0.568421052631579,-0.49341021416804,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.779,-0.485,"8:7","125/150","I:V:P:A:E",3.88541626053988,0.0002118075877292,1.0488367141091,3.70450062271154,9.31977387255173,893.783372292271,1.68741488635211,1.95392414212297e-07,6.70909230105579,6.91781679568266,2088.84994220519,1.03281930722422e-09,"lineage4","dr_mutations_pyrazinamide","LEU",0,"SRR671868,BGI_143","SRR671868","lineage4.5","cn","China","pnca_p.pro62leu","A","-","PRO","PA62","pnca_complex.pdb"
|
|
"P62L","L2","PZA","P","P62",62,"L",1,"MDR","DM","hydrophilic","hydrophobic","non-polar","non-polar","non-polar","non-polar",11.121,-0.276,-0.504,1.77658,-1.127,-0.59,54,75,-0.599,7,7,34,0.213836477987421,"loop",-1.93333333333333,3.99,0.0007905706482679,48.6872097931617,48.6872048041474,48.6746878162623,37.2619168572472,0,-2,0,0,-2,0,0,0,0,0,0,0,0,0,0,0,0,-1,-2,-7,1,2,0,4,2,-0.0699088145896656,-0.130232558139535,0.0647069107438137,-0.192156862745098,-0.154450261780105,0.568421052631579,-0.49341021416804,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.779,-0.485,"8:7","125/150","I:V:P:A:E",3.88541626053988,0.0002118075877292,1.0488367141091,3.70450062271154,9.31977387255173,893.783372292271,1.68741488635211,1.95392414212297e-07,6.70909230105579,6.91781679568266,2088.84994220519,1.03281930722422e-09,"lineage2","dr_mutations_pyrazinamide","LEU",0,"SRR6339640","SRR6339640","lineage2.2.1","au","Australia","pnca_p.pro62leu","A","-","PRO","PA62","pnca_complex.pdb"
|
|
"P62L","L2","PZA","P","P62",62,"L",1,"MDR","DM","hydrophilic","hydrophobic","non-polar","non-polar","non-polar","non-polar",11.121,-0.276,-0.504,1.77658,-1.127,-0.59,54,75,-0.599,7,7,34,0.213836477987421,"loop",-1.93333333333333,3.99,0.0007905706482679,48.6872097931617,48.6872048041474,48.6746878162623,37.2619168572472,0,-2,0,0,-2,0,0,0,0,0,0,0,0,0,0,0,0,-1,-2,-7,1,2,0,4,2,-0.0699088145896656,-0.130232558139535,0.0647069107438137,-0.192156862745098,-0.154450261780105,0.568421052631579,-0.49341021416804,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.779,-0.485,"8:7","125/150","I:V:P:A:E",3.88541626053988,0.0002118075877292,1.0488367141091,3.70450062271154,9.31977387255173,893.783372292271,1.68741488635211,1.95392414212297e-07,6.70909230105579,6.91781679568266,2088.84994220519,1.03281930722422e-09,"lineage2","dr_mutations_pyrazinamide","LEU",0,"MDR_16136","SRR6824384","lineage2.2.1","cn","China: Song County, Luoyang City, Henan Province","pnca_p.pro62leu","A","-","PRO","PA62","pnca_complex.pdb"
|
|
"P62L","L2","PZA","P","P62",62,"L",1,"MDR","DM","hydrophilic","hydrophobic","non-polar","non-polar","non-polar","non-polar",11.121,-0.276,-0.504,1.77658,-1.127,-0.59,54,75,-0.599,7,7,34,0.213836477987421,"loop",-1.93333333333333,3.99,0.0007905706482679,48.6872097931617,48.6872048041474,48.6746878162623,37.2619168572472,0,-2,0,0,-2,0,0,0,0,0,0,0,0,0,0,0,0,-1,-2,-7,1,2,0,4,2,-0.0699088145896656,-0.130232558139535,0.0647069107438137,-0.192156862745098,-0.154450261780105,0.568421052631579,-0.49341021416804,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.779,-0.485,"8:7","125/150","I:V:P:A:E",3.88541626053988,0.0002118075877292,1.0488367141091,3.70450062271154,9.31977387255173,893.783372292271,1.68741488635211,1.95392414212297e-07,6.70909230105579,6.91781679568266,2088.84994220519,1.03281930722422e-09,"lineage2","dr_mutations_pyrazinamide","LEU",0,"MDR_12340","SRR6824498","lineage2.2.1","cn","China: Xuanzhou District, Xuancheng City, Anhui Province","pnca_p.pro62leu","A","-","PRO","PA62","pnca_complex.pdb"
|
|
"P62L","L4","PZA","P","P62",62,"L",NA,"Pre-XDR","DM","hydrophilic","hydrophobic","non-polar","non-polar","non-polar","non-polar",11.121,-0.276,-0.504,1.77658,-1.127,-0.59,54,75,-0.599,7,7,34,0.213836477987421,"loop",-1.93333333333333,3.99,0.0007905706482679,48.6872097931617,48.6872048041474,48.6746878162623,37.2619168572472,0,-2,0,0,-2,0,0,0,0,0,0,0,0,0,0,0,0,-1,-2,-7,1,2,0,4,2,-0.0699088145896656,-0.130232558139535,0.0647069107438137,-0.192156862745098,-0.154450261780105,0.568421052631579,-0.49341021416804,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.779,-0.485,"8:7","125/150","I:V:P:A:E",3.88541626053988,0.0002118075877292,1.0488367141091,3.70450062271154,9.31977387255173,893.783372292271,1.68741488635211,1.95392414212297e-07,6.70909230105579,6.91781679568266,2088.84994220519,1.03281930722422e-09,"lineage4","dr_mutations_pyrazinamide","LEU",0,"ERR2515337","ERR2515337","lineage4.1.1.3","za","South Africa","pnca_p.pro62leu","A","-","PRO","PA62","pnca_complex.pdb"
|
|
"P62L","L4","PZA","P","P62",62,"L",1,"XDR","DM","hydrophilic","hydrophobic","non-polar","non-polar","non-polar","non-polar",11.121,-0.276,-0.504,1.77658,-1.127,-0.59,54,75,-0.599,7,7,34,0.213836477987421,"loop",-1.93333333333333,3.99,0.0007905706482679,48.6872097931617,48.6872048041474,48.6746878162623,37.2619168572472,0,-2,0,0,-2,0,0,0,0,0,0,0,0,0,0,0,0,-1,-2,-7,1,2,0,4,2,-0.0699088145896656,-0.130232558139535,0.0647069107438137,-0.192156862745098,-0.154450261780105,0.568421052631579,-0.49341021416804,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.779,-0.485,"8:7","125/150","I:V:P:A:E",3.88541626053988,0.0002118075877292,1.0488367141091,3.70450062271154,9.31977387255173,893.783372292271,1.68741488635211,1.95392414212297e-07,6.70909230105579,6.91781679568266,2088.84994220519,1.03281930722422e-09,"lineage4","dr_mutations_pyrazinamide","LEU",0,"ERR1034815","ERR1034815","lineage4.3.4.1","pt","Portugal","pnca_p.pro62leu","A","-","PRO","PA62","pnca_complex.pdb"
|
|
"P62L","L2","PZA","P","P62",62,"L",NA,"MDR","DM","hydrophilic","hydrophobic","non-polar","non-polar","non-polar","non-polar",11.121,-0.276,-0.504,1.77658,-1.127,-0.59,54,75,-0.599,7,7,34,0.213836477987421,"loop",-1.93333333333333,3.99,0.0007905706482679,48.6872097931617,48.6872048041474,48.6746878162623,37.2619168572472,0,-2,0,0,-2,0,0,0,0,0,0,0,0,0,0,0,0,-1,-2,-7,1,2,0,4,2,-0.0699088145896656,-0.130232558139535,0.0647069107438137,-0.192156862745098,-0.154450261780105,0.568421052631579,-0.49341021416804,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.779,-0.485,"8:7","125/150","I:V:P:A:E",3.88541626053988,0.0002118075877292,1.0488367141091,3.70450062271154,9.31977387255173,893.783372292271,1.68741488635211,1.95392414212297e-07,6.70909230105579,6.91781679568266,2088.84994220519,1.03281930722422e-09,"lineage2","dr_mutations_pyrazinamide","LEU",0,"SRS796962","SRR1723447_SRR1723446","lineage2.2.1","cn","China:Anhui","pnca_p.pro62leu","A","-","PRO","PA62","pnca_complex.pdb"
|
|
"P62L","L4","PZA","P","P62",62,"L",NA,"Pre-XDR","DM","hydrophilic","hydrophobic","non-polar","non-polar","non-polar","non-polar",11.121,-0.276,-0.504,1.77658,-1.127,-0.59,54,75,-0.599,7,7,34,0.213836477987421,"loop",-1.93333333333333,3.99,0.0007905706482679,48.6872097931617,48.6872048041474,48.6746878162623,37.2619168572472,0,-2,0,0,-2,0,0,0,0,0,0,0,0,0,0,0,0,-1,-2,-7,1,2,0,4,2,-0.0699088145896656,-0.130232558139535,0.0647069107438137,-0.192156862745098,-0.154450261780105,0.568421052631579,-0.49341021416804,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.779,-0.485,"8:7","125/150","I:V:P:A:E",3.88541626053988,0.0002118075877292,1.0488367141091,3.70450062271154,9.31977387255173,893.783372292271,1.68741488635211,1.95392414212297e-07,6.70909230105579,6.91781679568266,2088.84994220519,1.03281930722422e-09,"lineage4","dr_mutations_pyrazinamide","LEU",0,"SAMN02567708","SRR1166134","lineage4.2.1","ro","Romania","pnca_p.pro62leu","A","-","PRO","PA62","pnca_complex.pdb"
|
|
"P62Q","L4","PZA","P","P62",62,"Q",NA,"Pre-MDR","DM","hydrophilic","hydrophilic","non-polar","neutral","non-polar","polar",11.121,0.708,-0.763,1.97038,-0.98,-0.28,50,75,-0.599,7,7,34,0.213836477987421,"loop",-1.93333333333333,3.99,NA,NA,NA,NA,NA,-6,0,0,0,0,0,0,0,0,-3,0,-1,-2,0,0,0,0,-7,-2,-3,-3,0,0,0,0,0.317488789237668,-0.197157622739018,0.071765528595051,-0.167092924126172,-0.0732984293193717,0.526315789473684,-0.49341021416804,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.779,-0.485,"8:7","125/150","I:V:P:A:E",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage4","dr_mutations_pyrazinamide","GLN",0,"SRR5065206","SRR5065206","lineage4.4.1.2","vn","Vietnam","pnca_p.pro62gln","A","-","PRO","PA62","pnca_complex.pdb"
|
|
"P62R","L4","PZA","P","P62",62,"R",NA,"XDR","DM","hydrophilic","hydrophilic","non-polar","basic","non-polar","pos",11.121,0.023,-0.186,2.51854,-1.078,-0.18,61,80,-0.599,7,7,34,0.213836477987421,"loop",-1.93333333333333,3.99,NA,NA,NA,NA,NA,-20,-14,0,0,-14,0,0,0,0,0,0,0,0,0,0,0,0,-7,-2,-1,-5,-2,0,0,0,0.0103139013452914,-0.0480620155038759,0.0917307089940923,-0.183802216538789,-0.0471204188481675,0.642105263157895,-0.49341021416804,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.779,-0.485,"8:7","125/150","I:V:P:A:E",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERR775322","ERR775322","lineage4.1.1","pe","","pnca_p.pro62arg","A","-","PRO","PA62","pnca_complex.pdb"
|
|
"P62R","L4","PZA","P","P62",62,"R",NA,"MDR","DM","hydrophilic","hydrophilic","non-polar","basic","non-polar","pos",11.121,0.023,-0.186,2.51854,-1.078,-0.18,61,80,-0.599,7,7,34,0.213836477987421,"loop",-1.93333333333333,3.99,NA,NA,NA,NA,NA,-20,-14,0,0,-14,0,0,0,0,0,0,0,0,0,0,0,0,-7,-2,-1,-5,-2,0,0,0,0.0103139013452914,-0.0480620155038759,0.0917307089940923,-0.183802216538789,-0.0471204188481675,0.642105263157895,-0.49341021416804,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.779,-0.485,"8:7","125/150","I:V:P:A:E",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERR1035335","ERR1035335","lineage4.3.3","br","Brazil","pnca_p.pro62arg","A","-","PRO","PA62","pnca_complex.pdb"
|
|
"P62R","L4","PZA","P","P62",62,"R",NA,"Pre-XDR","DM","hydrophilic","hydrophilic","non-polar","basic","non-polar","pos",11.121,0.023,-0.186,2.51854,-1.078,-0.18,61,80,-0.599,7,7,34,0.213836477987421,"loop",-1.93333333333333,3.99,NA,NA,NA,NA,NA,-20,-14,0,0,-14,0,0,0,0,0,0,0,0,0,0,0,0,-7,-2,-1,-5,-2,0,0,0,0.0103139013452914,-0.0480620155038759,0.0917307089940923,-0.183802216538789,-0.0471204188481675,0.642105263157895,-0.49341021416804,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.779,-0.485,"8:7","125/150","I:V:P:A:E",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERR751451","ERR751451","lineage4.1.1","pe","","pnca_p.pro62arg","A","-","PRO","PA62","pnca_complex.pdb"
|
|
"P62S","L2","PZA","P","P62",62,"S",0,"XDR","DM","hydrophilic","hydrophilic","non-polar","neutral","non-polar","polar",11.121,0.534,-1.342,1.54135,-1.161,-1.23,50,75,-0.599,7,7,34,0.213836477987421,"loop",-1.93333333333333,3.99,0.0003593502946672,1.21225820016821,1.21225918982515,1.212214074125,7.19297638498975e-25,0,0,0,0,0,0,0,0,0,-2,0,-2,0,0,0,0,0,-3,-2,-1,0,-4,0,-4,0,0.239461883408072,-0.346770025839793,0.0561393221104466,-0.197953964194373,-0.321989528795811,0.526315789473684,-0.49341021416804,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.779,-0.485,"8:7","125/150","I:V:P:A:E",0.192485717774876,0.863268405978748,1.11770505415734,0.172215126932565,0.0619550849552706,8.19905671742343,0.083595130527928,1,0,0.0246053772172713,12.260612593354,0.999999999999323,"lineage2","dr_mutations_pyrazinamide","SER",0,"ERR2517004","ERR2517004","lineage2.2.1","gb","UK","pnca_p.pro62ser","A","-","PRO","PA62","pnca_complex.pdb"
|
|
"P62S","L2","PZA","P","P62",62,"S",0,"XDR","DM","hydrophilic","hydrophilic","non-polar","neutral","non-polar","polar",11.121,0.534,-1.342,1.54135,-1.161,-1.23,50,75,-0.599,7,7,34,0.213836477987421,"loop",-1.93333333333333,3.99,0.0003593502946672,1.21225820016821,1.21225918982515,1.212214074125,7.19297638498975e-25,0,0,0,0,0,0,0,0,0,-2,0,-2,0,0,0,0,0,-3,-2,-1,0,-4,0,-4,0,0.239461883408072,-0.346770025839793,0.0561393221104466,-0.197953964194373,-0.321989528795811,0.526315789473684,-0.49341021416804,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.779,-0.485,"8:7","125/150","I:V:P:A:E",0.192485717774876,0.863268405978748,1.11770505415734,0.172215126932565,0.0619550849552706,8.19905671742343,0.083595130527928,1,0,0.0246053772172713,12.260612593354,0.999999999999323,"lineage2","dr_mutations_pyrazinamide","SER",0,"ERR2516981","ERR2516981","lineage2.2.1","gb","UK","pnca_p.pro62ser","A","-","PRO","PA62","pnca_complex.pdb"
|
|
"P62S","L2","PZA","P","P62",62,"S",1,"XDR","DM","hydrophilic","hydrophilic","non-polar","neutral","non-polar","polar",11.121,0.534,-1.342,1.54135,-1.161,-1.23,50,75,-0.599,7,7,34,0.213836477987421,"loop",-1.93333333333333,3.99,0.0003593502946672,1.21225820016821,1.21225918982515,1.212214074125,7.19297638498975e-25,0,0,0,0,0,0,0,0,0,-2,0,-2,0,0,0,0,0,-3,-2,-1,0,-4,0,-4,0,0.239461883408072,-0.346770025839793,0.0561393221104466,-0.197953964194373,-0.321989528795811,0.526315789473684,-0.49341021416804,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.779,-0.485,"8:7","125/150","I:V:P:A:E",0.192485717774876,0.863268405978748,1.11770505415734,0.172215126932565,0.0619550849552706,8.19905671742343,0.083595130527928,1,0,0.0246053772172713,12.260612593354,0.999999999999323,"lineage2","dr_mutations_pyrazinamide","SER",0,"ERR2516285","ERR2516285","lineage2.2.1","be","Belgium","pnca_p.pro62ser","A","-","PRO","PA62","pnca_complex.pdb"
|
|
"P62S","L2","PZA","P","P62",62,"S",NA,"XDR","DM","hydrophilic","hydrophilic","non-polar","neutral","non-polar","polar",11.121,0.534,-1.342,1.54135,-1.161,-1.23,50,75,-0.599,7,7,34,0.213836477987421,"loop",-1.93333333333333,3.99,0.0003593502946672,1.21225820016821,1.21225918982515,1.212214074125,7.19297638498975e-25,0,0,0,0,0,0,0,0,0,-2,0,-2,0,0,0,0,0,-3,-2,-1,0,-4,0,-4,0,0.239461883408072,-0.346770025839793,0.0561393221104466,-0.197953964194373,-0.321989528795811,0.526315789473684,-0.49341021416804,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.779,-0.485,"8:7","125/150","I:V:P:A:E",0.192485717774876,0.863268405978748,1.11770505415734,0.172215126932565,0.0619550849552706,8.19905671742343,0.083595130527928,1,0,0.0246053772172713,12.260612593354,0.999999999999323,"lineage2","dr_mutations_pyrazinamide","SER",0,"ERR158602","ERR158602","lineage2.2.1","gb","UK","pnca_p.pro62ser","A","-","PRO","PA62","pnca_complex.pdb"
|
|
"P62S","L6","PZA","P","P62",62,"S",0,"MDR","DM","hydrophilic","hydrophilic","non-polar","neutral","non-polar","polar",11.121,0.534,-1.342,1.54135,-1.161,-1.23,50,75,-0.599,7,7,34,0.213836477987421,"loop",-1.93333333333333,3.99,0.0003593502946672,1.21225820016821,1.21225918982515,1.212214074125,7.19297638498975e-25,0,0,0,0,0,0,0,0,0,-2,0,-2,0,0,0,0,0,-3,-2,-1,0,-4,0,-4,0,0.239461883408072,-0.346770025839793,0.0561393221104466,-0.197953964194373,-0.321989528795811,0.526315789473684,-0.49341021416804,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.779,-0.485,"8:7","125/150","I:V:P:A:E",0.192485717774876,0.863268405978748,1.11770505415734,0.172215126932565,0.0619550849552706,8.19905671742343,0.083595130527928,1,0,0.0246053772172713,12.260612593354,0.999999999999323,"lineage6","dr_mutations_pyrazinamide","SER",0,"ERR553000,ERS458461,8864-03","ERR553000","lineage6","","","pnca_p.pro62ser","A","-","PRO","PA62","pnca_complex.pdb"
|
|
"P62S","L2","PZA","P","P62",62,"S",0,"XDR","DM","hydrophilic","hydrophilic","non-polar","neutral","non-polar","polar",11.121,0.534,-1.342,1.54135,-1.161,-1.23,50,75,-0.599,7,7,34,0.213836477987421,"loop",-1.93333333333333,3.99,0.0003593502946672,1.21225820016821,1.21225918982515,1.212214074125,7.19297638498975e-25,0,0,0,0,0,0,0,0,0,-2,0,-2,0,0,0,0,0,-3,-2,-1,0,-4,0,-4,0,0.239461883408072,-0.346770025839793,0.0561393221104466,-0.197953964194373,-0.321989528795811,0.526315789473684,-0.49341021416804,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.779,-0.485,"8:7","125/150","I:V:P:A:E",0.192485717774876,0.863268405978748,1.11770505415734,0.172215126932565,0.0619550849552706,8.19905671742343,0.083595130527928,1,0,0.0246053772172713,12.260612593354,0.999999999999323,"lineage2","dr_mutations_pyrazinamide","SER",0,"ERR2516950","ERR2516950","lineage2.2.1","gb","UK","pnca_p.pro62ser","A","-","PRO","PA62","pnca_complex.pdb"
|
|
"P62T","L3","PZA","P","P62",62,"T",1,"Pre-XDR","OM","hydrophilic","hydrophobic","non-polar","neutral","non-polar","polar",11.121,0.522,-1.056,2.20908,-1.242,-0.58,55,75,-0.599,7,7,34,0.213836477987421,"loop",-1.93333333333333,3.99,0.0002156101768003,29.1287878787879,511969.848429208,Inf,9.2872640727157,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-9,-2,-5,-2,-4,0,-4,0,0.234080717488789,-0.272868217054264,0.0804595021816884,-0.211764705882353,-0.151832460732984,0.578947368421053,-0.49341021416804,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.779,-0.485,"8:7","125/150","I:V:P:A:E",13.1460210125009,0.907969111549634,113.719344731975,0.115600569485207,0.183926936276724,NA,1.4643224129316,0.0049931328456149,2.3016268790981,2.00455510251839,Inf,0.0023075254069185,"lineage3","other_mutations_pyrazinamide","THR",0,"ERR2510418","ERR2510418","lineage3","pk","Pakistan","pnca_p.pro62thr","A","-","PRO","PA62","pnca_complex.pdb"
|
|
"P62T","L4","PZA","P","P62",62,"T",1,"MDR","OM","hydrophilic","hydrophobic","non-polar","neutral","non-polar","polar",11.121,0.522,-1.056,2.20908,-1.242,-0.58,55,75,-0.599,7,7,34,0.213836477987421,"loop",-1.93333333333333,3.99,0.0002156101768003,29.1287878787879,511969.848429208,Inf,9.2872640727157,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-9,-2,-5,-2,-4,0,-4,0,0.234080717488789,-0.272868217054264,0.0804595021816884,-0.211764705882353,-0.151832460732984,0.578947368421053,-0.49341021416804,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.779,-0.485,"8:7","125/150","I:V:P:A:E",13.1460210125009,0.907969111549634,113.719344731975,0.115600569485207,0.183926936276724,NA,1.4643224129316,0.0049931328456149,2.3016268790981,2.00455510251839,Inf,0.0023075254069185,"lineage4","other_mutations_pyrazinamide","THR",0,"ERR2510851","ERR2510851","lineage4.3.2","it","Italy","pnca_p.pro62thr","A","-","PRO","PA62","pnca_complex.pdb"
|
|
"P62T","L4","PZA","P","P62",62,"T",1,"Pre-XDR","OM","hydrophilic","hydrophobic","non-polar","neutral","non-polar","polar",11.121,0.522,-1.056,2.20908,-1.242,-0.58,55,75,-0.599,7,7,34,0.213836477987421,"loop",-1.93333333333333,3.99,0.0002156101768003,29.1287878787879,511969.848429208,Inf,9.2872640727157,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-9,-2,-5,-2,-4,0,-4,0,0.234080717488789,-0.272868217054264,0.0804595021816884,-0.211764705882353,-0.151832460732984,0.578947368421053,-0.49341021416804,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.779,-0.485,"8:7","125/150","I:V:P:A:E",13.1460210125009,0.907969111549634,113.719344731975,0.115600569485207,0.183926936276724,NA,1.4643224129316,0.0049931328456149,2.3016268790981,2.00455510251839,Inf,0.0023075254069185,"lineage4","other_mutations_pyrazinamide","THR",0,"ERR2516161","ERR2516161","lineage4.3.3","es","Spain","pnca_p.pro62thr","A","-","PRO","PA62","pnca_complex.pdb"
|
|
"P62T","L4","PZA","P","P62",62,"T",NA,"MDR","OM","hydrophilic","hydrophobic","non-polar","neutral","non-polar","polar",11.121,0.522,-1.056,2.20908,-1.242,-0.58,55,75,-0.599,7,7,34,0.213836477987421,"loop",-1.93333333333333,3.99,0.0002156101768003,29.1287878787879,511969.848429208,Inf,9.2872640727157,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-9,-2,-5,-2,-4,0,-4,0,0.234080717488789,-0.272868217054264,0.0804595021816884,-0.211764705882353,-0.151832460732984,0.578947368421053,-0.49341021416804,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.779,-0.485,"8:7","125/150","I:V:P:A:E",13.1460210125009,0.907969111549634,113.719344731975,0.115600569485207,0.183926936276724,NA,1.4643224129316,0.0049931328456149,2.3016268790981,2.00455510251839,Inf,0.0023075254069185,"lineage4","other_mutations_pyrazinamide","THR",0,"ERR1193860","ERR1193860","lineage4.3.3","de","Germany","pnca_p.pro62thr","A","-","PRO","PA62","pnca_complex.pdb"
|
|
"D63A","L2","PZA","D","D63",63,"A",1,"MDR","DM","hydrophilic","hydrophobic","acidic","non-polar","neg","non-polar",10.737,-0.769,-0.714,4.4472,-0.704,0.12,40,71,-0.741,8,8,84,0.435233160621762,"loop",-2.13333333333333,3.62,0.0009343107661348,26.7869510135135,26.7869506340703,26.7708032978517,37.2159659891988,2,12,0,0,12,0,0,0,0,4,0,4,6,0,0,0,0,3,0,3,0,0,0,2,1,-0.194782168186423,-0.184496124031008,0.16197670437576,-0.12003410059676,0.0674157303370786,0.421052631578947,-0.610378912685338,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.872,-0.674,"8:7","125/150","W:D:M:G:N:F:Y:E",3.28791485229524,1.90630753051068e-05,0.768996545261043,4.275591187707,7.18677177005967,173.199151011581,1.42792328347145,1.9896368453757e-07,6.70122618511891,5.83859157504838,247.443798048456,1.05744462378296e-09,"lineage2","dr_mutations_pyrazinamide","ALA",0,"ERR1034857","ERR1034857","lineage2.2.1","pt","Portugal","pnca_p.asp63ala","A","-","ASP","DA63","pnca_complex.pdb"
|
|
"D63A","L2","PZA","D","D63",63,"A",NA,"XDR","DM","hydrophilic","hydrophobic","acidic","non-polar","neg","non-polar",10.737,-0.769,-0.714,4.4472,-0.704,0.12,40,71,-0.741,8,8,84,0.435233160621762,"loop",-2.13333333333333,3.62,0.0009343107661348,26.7869510135135,26.7869506340703,26.7708032978517,37.2159659891988,2,12,0,0,12,0,0,0,0,4,0,4,6,0,0,0,0,3,0,3,0,0,0,2,1,-0.194782168186423,-0.184496124031008,0.16197670437576,-0.12003410059676,0.0674157303370786,0.421052631578947,-0.610378912685338,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.872,-0.674,"8:7","125/150","W:D:M:G:N:F:Y:E",3.28791485229524,1.90630753051068e-05,0.768996545261043,4.275591187707,7.18677177005967,173.199151011581,1.42792328347145,1.9896368453757e-07,6.70122618511891,5.83859157504838,247.443798048456,1.05744462378296e-09,"lineage2","dr_mutations_pyrazinamide","ALA",0,"SRR8791319","SRR8791319","lineage2.2.1","","","pnca_p.asp63ala","A","-","ASP","DA63","pnca_complex.pdb"
|
|
"D63A","L4","PZA","D","D63",63,"A",NA,"MDR","DM","hydrophilic","hydrophobic","acidic","non-polar","neg","non-polar",10.737,-0.769,-0.714,4.4472,-0.704,0.12,40,71,-0.741,8,8,84,0.435233160621762,"loop",-2.13333333333333,3.62,0.0009343107661348,26.7869510135135,26.7869506340703,26.7708032978517,37.2159659891988,2,12,0,0,12,0,0,0,0,4,0,4,6,0,0,0,0,3,0,3,0,0,0,2,1,-0.194782168186423,-0.184496124031008,0.16197670437576,-0.12003410059676,0.0674157303370786,0.421052631578947,-0.610378912685338,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.872,-0.674,"8:7","125/150","W:D:M:G:N:F:Y:E",3.28791485229524,1.90630753051068e-05,0.768996545261043,4.275591187707,7.18677177005967,173.199151011581,1.42792328347145,1.9896368453757e-07,6.70122618511891,5.83859157504838,247.443798048456,1.05744462378296e-09,"lineage4","dr_mutations_pyrazinamide","ALA",0,"ERR2179651","ERR2179651","lineage4.4.2","cn","China","pnca_p.asp63ala","A","-","ASP","DA63","pnca_complex.pdb"
|
|
"D63A","L4","PZA","D","D63",63,"A",NA,"Pre-MDR","DM","hydrophilic","hydrophobic","acidic","non-polar","neg","non-polar",10.737,-0.769,-0.714,4.4472,-0.704,0.12,40,71,-0.741,8,8,84,0.435233160621762,"loop",-2.13333333333333,3.62,0.0009343107661348,26.7869510135135,26.7869506340703,26.7708032978517,37.2159659891988,2,12,0,0,12,0,0,0,0,4,0,4,6,0,0,0,0,3,0,3,0,0,0,2,1,-0.194782168186423,-0.184496124031008,0.16197670437576,-0.12003410059676,0.0674157303370786,0.421052631578947,-0.610378912685338,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.872,-0.674,"8:7","125/150","W:D:M:G:N:F:Y:E",3.28791485229524,1.90630753051068e-05,0.768996545261043,4.275591187707,7.18677177005967,173.199151011581,1.42792328347145,1.9896368453757e-07,6.70122618511891,5.83859157504838,247.443798048456,1.05744462378296e-09,"lineage4","dr_mutations_pyrazinamide","ALA",0,"SRR024073","SRR024073","lineage4.1.2.1","","unknown","pnca_p.asp63ala","A","-","ASP","DA63","pnca_complex.pdb"
|
|
"D63A","L2","PZA","D","D63",63,"A",0,"MDR","DM","hydrophilic","hydrophobic","acidic","non-polar","neg","non-polar",10.737,-0.769,-0.714,4.4472,-0.704,0.12,40,71,-0.741,8,8,84,0.435233160621762,"loop",-2.13333333333333,3.62,0.0009343107661348,26.7869510135135,26.7869506340703,26.7708032978517,37.2159659891988,2,12,0,0,12,0,0,0,0,4,0,4,6,0,0,0,0,3,0,3,0,0,0,2,1,-0.194782168186423,-0.184496124031008,0.16197670437576,-0.12003410059676,0.0674157303370786,0.421052631578947,-0.610378912685338,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.872,-0.674,"8:7","125/150","W:D:M:G:N:F:Y:E",3.28791485229524,1.90630753051068e-05,0.768996545261043,4.275591187707,7.18677177005967,173.199151011581,1.42792328347145,1.9896368453757e-07,6.70122618511891,5.83859157504838,247.443798048456,1.05744462378296e-09,"lineage2","dr_mutations_pyrazinamide","ALA",0,"ERR2864296","ERR2864296","lineage2.2.1","pt","Portugal","pnca_p.asp63ala","A","-","ASP","DA63","pnca_complex.pdb"
|
|
"D63A","L2","PZA","D","D63",63,"A",1,"MDR","DM","hydrophilic","hydrophobic","acidic","non-polar","neg","non-polar",10.737,-0.769,-0.714,4.4472,-0.704,0.12,40,71,-0.741,8,8,84,0.435233160621762,"loop",-2.13333333333333,3.62,0.0009343107661348,26.7869510135135,26.7869506340703,26.7708032978517,37.2159659891988,2,12,0,0,12,0,0,0,0,4,0,4,6,0,0,0,0,3,0,3,0,0,0,2,1,-0.194782168186423,-0.184496124031008,0.16197670437576,-0.12003410059676,0.0674157303370786,0.421052631578947,-0.610378912685338,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.872,-0.674,"8:7","125/150","W:D:M:G:N:F:Y:E",3.28791485229524,1.90630753051068e-05,0.768996545261043,4.275591187707,7.18677177005967,173.199151011581,1.42792328347145,1.9896368453757e-07,6.70122618511891,5.83859157504838,247.443798048456,1.05744462378296e-09,"lineage2","dr_mutations_pyrazinamide","ALA",0,"ERR1034826","ERR1034826","lineage2.2.1","pt","Portugal","pnca_p.asp63ala","A","-","ASP","DA63","pnca_complex.pdb"
|
|
"D63A","L2","PZA","D","D63",63,"A",1,"MDR","DM","hydrophilic","hydrophobic","acidic","non-polar","neg","non-polar",10.737,-0.769,-0.714,4.4472,-0.704,0.12,40,71,-0.741,8,8,84,0.435233160621762,"loop",-2.13333333333333,3.62,0.0009343107661348,26.7869510135135,26.7869506340703,26.7708032978517,37.2159659891988,2,12,0,0,12,0,0,0,0,4,0,4,6,0,0,0,0,3,0,3,0,0,0,2,1,-0.194782168186423,-0.184496124031008,0.16197670437576,-0.12003410059676,0.0674157303370786,0.421052631578947,-0.610378912685338,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.872,-0.674,"8:7","125/150","W:D:M:G:N:F:Y:E",3.28791485229524,1.90630753051068e-05,0.768996545261043,4.275591187707,7.18677177005967,173.199151011581,1.42792328347145,1.9896368453757e-07,6.70122618511891,5.83859157504838,247.443798048456,1.05744462378296e-09,"lineage2","dr_mutations_pyrazinamide","ALA",0,"ERR1035242","ERR1035242","lineage2.2.1","pt","Portugal","pnca_p.asp63ala","A","-","ASP","DA63","pnca_complex.pdb"
|
|
"D63A","L2","PZA","D","D63",63,"A",1,"Pre-XDR","DM","hydrophilic","hydrophobic","acidic","non-polar","neg","non-polar",10.737,-0.769,-0.714,4.4472,-0.704,0.12,40,71,-0.741,8,8,84,0.435233160621762,"loop",-2.13333333333333,3.62,0.0009343107661348,26.7869510135135,26.7869506340703,26.7708032978517,37.2159659891988,2,12,0,0,12,0,0,0,0,4,0,4,6,0,0,0,0,3,0,3,0,0,0,2,1,-0.194782168186423,-0.184496124031008,0.16197670437576,-0.12003410059676,0.0674157303370786,0.421052631578947,-0.610378912685338,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.872,-0.674,"8:7","125/150","W:D:M:G:N:F:Y:E",3.28791485229524,1.90630753051068e-05,0.768996545261043,4.275591187707,7.18677177005967,173.199151011581,1.42792328347145,1.9896368453757e-07,6.70122618511891,5.83859157504838,247.443798048456,1.05744462378296e-09,"lineage2","dr_mutations_pyrazinamide","ALA",0,"ERS2592760","ERR2677412","lineage2.2.1","de","Germany","pnca_p.asp63ala","A","-","ASP","DA63","pnca_complex.pdb"
|
|
"D63A","L2","PZA","D","D63",63,"A",NA,"MDR","DM","hydrophilic","hydrophobic","acidic","non-polar","neg","non-polar",10.737,-0.769,-0.714,4.4472,-0.704,0.12,40,71,-0.741,8,8,84,0.435233160621762,"loop",-2.13333333333333,3.62,0.0009343107661348,26.7869510135135,26.7869506340703,26.7708032978517,37.2159659891988,2,12,0,0,12,0,0,0,0,4,0,4,6,0,0,0,0,3,0,3,0,0,0,2,1,-0.194782168186423,-0.184496124031008,0.16197670437576,-0.12003410059676,0.0674157303370786,0.421052631578947,-0.610378912685338,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.872,-0.674,"8:7","125/150","W:D:M:G:N:F:Y:E",3.28791485229524,1.90630753051068e-05,0.768996545261043,4.275591187707,7.18677177005967,173.199151011581,1.42792328347145,1.9896368453757e-07,6.70122618511891,5.83859157504838,247.443798048456,1.05744462378296e-09,"lineage2","dr_mutations_pyrazinamide","ALA",0,"ERR275226","ERR275226","lineage2.2.1","pt","Portugal","pnca_p.asp63ala","A","-","ASP","DA63","pnca_complex.pdb"
|
|
"D63A","L4","PZA","D","D63",63,"A",NA,"MDR","DM","hydrophilic","hydrophobic","acidic","non-polar","neg","non-polar",10.737,-0.769,-0.714,4.4472,-0.704,0.12,40,71,-0.741,8,8,84,0.435233160621762,"loop",-2.13333333333333,3.62,0.0009343107661348,26.7869510135135,26.7869506340703,26.7708032978517,37.2159659891988,2,12,0,0,12,0,0,0,0,4,0,4,6,0,0,0,0,3,0,3,0,0,0,2,1,-0.194782168186423,-0.184496124031008,0.16197670437576,-0.12003410059676,0.0674157303370786,0.421052631578947,-0.610378912685338,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.872,-0.674,"8:7","125/150","W:D:M:G:N:F:Y:E",3.28791485229524,1.90630753051068e-05,0.768996545261043,4.275591187707,7.18677177005967,173.199151011581,1.42792328347145,1.9896368453757e-07,6.70122618511891,5.83859157504838,247.443798048456,1.05744462378296e-09,"lineage4","dr_mutations_pyrazinamide","ALA",0,"SRS797443","SRR1723983","lineage4.4.2","cn","China:Zhejiang","pnca_p.asp63ala","A","-","ASP","DA63","pnca_complex.pdb"
|
|
"D63A","L2","PZA","D","D63",63,"A",1,"MDR","DM","hydrophilic","hydrophobic","acidic","non-polar","neg","non-polar",10.737,-0.769,-0.714,4.4472,-0.704,0.12,40,71,-0.741,8,8,84,0.435233160621762,"loop",-2.13333333333333,3.62,0.0009343107661348,26.7869510135135,26.7869506340703,26.7708032978517,37.2159659891988,2,12,0,0,12,0,0,0,0,4,0,4,6,0,0,0,0,3,0,3,0,0,0,2,1,-0.194782168186423,-0.184496124031008,0.16197670437576,-0.12003410059676,0.0674157303370786,0.421052631578947,-0.610378912685338,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.872,-0.674,"8:7","125/150","W:D:M:G:N:F:Y:E",3.28791485229524,1.90630753051068e-05,0.768996545261043,4.275591187707,7.18677177005967,173.199151011581,1.42792328347145,1.9896368453757e-07,6.70122618511891,5.83859157504838,247.443798048456,1.05744462378296e-09,"lineage2","dr_mutations_pyrazinamide","ALA",0,"ERR2516188","ERR2516188","lineage2.2.1","be","Belgium","pnca_p.asp63ala","A","-","ASP","DA63","pnca_complex.pdb"
|
|
"D63A","L2","PZA","D","D63",63,"A",1,"MDR","DM","hydrophilic","hydrophobic","acidic","non-polar","neg","non-polar",10.737,-0.769,-0.714,4.4472,-0.704,0.12,40,71,-0.741,8,8,84,0.435233160621762,"loop",-2.13333333333333,3.62,0.0009343107661348,26.7869510135135,26.7869506340703,26.7708032978517,37.2159659891988,2,12,0,0,12,0,0,0,0,4,0,4,6,0,0,0,0,3,0,3,0,0,0,2,1,-0.194782168186423,-0.184496124031008,0.16197670437576,-0.12003410059676,0.0674157303370786,0.421052631578947,-0.610378912685338,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.872,-0.674,"8:7","125/150","W:D:M:G:N:F:Y:E",3.28791485229524,1.90630753051068e-05,0.768996545261043,4.275591187707,7.18677177005967,173.199151011581,1.42792328347145,1.9896368453757e-07,6.70122618511891,5.83859157504838,247.443798048456,1.05744462378296e-09,"lineage2","dr_mutations_pyrazinamide","ALA",0,"ERR1036286","ERR1036286","lineage2.2.1","pt","Portugal","pnca_p.asp63ala","A","-","ASP","DA63","pnca_complex.pdb"
|
|
"D63A","L4","PZA","D","D63",63,"A",NA,"Pre-XDR","DM","hydrophilic","hydrophobic","acidic","non-polar","neg","non-polar",10.737,-0.769,-0.714,4.4472,-0.704,0.12,40,71,-0.741,8,8,84,0.435233160621762,"loop",-2.13333333333333,3.62,0.0009343107661348,26.7869510135135,26.7869506340703,26.7708032978517,37.2159659891988,2,12,0,0,12,0,0,0,0,4,0,4,6,0,0,0,0,3,0,3,0,0,0,2,1,-0.194782168186423,-0.184496124031008,0.16197670437576,-0.12003410059676,0.0674157303370786,0.421052631578947,-0.610378912685338,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.872,-0.674,"8:7","125/150","W:D:M:G:N:F:Y:E",3.28791485229524,1.90630753051068e-05,0.768996545261043,4.275591187707,7.18677177005967,173.199151011581,1.42792328347145,1.9896368453757e-07,6.70122618511891,5.83859157504838,247.443798048456,1.05744462378296e-09,"lineage4","dr_mutations_pyrazinamide","ALA",0,"ERR552036","ERR552036","lineage4.3.3","","","pnca_p.asp63ala","A","-","ASP","DA63","pnca_complex.pdb"
|
|
"D63A","L2","PZA","D","D63",63,"A",1,"MDR","DM","hydrophilic","hydrophobic","acidic","non-polar","neg","non-polar",10.737,-0.769,-0.714,4.4472,-0.704,0.12,40,71,-0.741,8,8,84,0.435233160621762,"loop",-2.13333333333333,3.62,0.0009343107661348,26.7869510135135,26.7869506340703,26.7708032978517,37.2159659891988,2,12,0,0,12,0,0,0,0,4,0,4,6,0,0,0,0,3,0,3,0,0,0,2,1,-0.194782168186423,-0.184496124031008,0.16197670437576,-0.12003410059676,0.0674157303370786,0.421052631578947,-0.610378912685338,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.872,-0.674,"8:7","125/150","W:D:M:G:N:F:Y:E",3.28791485229524,1.90630753051068e-05,0.768996545261043,4.275591187707,7.18677177005967,173.199151011581,1.42792328347145,1.9896368453757e-07,6.70122618511891,5.83859157504838,247.443798048456,1.05744462378296e-09,"lineage2","dr_mutations_pyrazinamide","ALA",0,"ERR2864235","ERR2864235","lineage2.2.1","pt","Portugal","pnca_p.asp63ala","A","-","ASP","DA63","pnca_complex.pdb"
|
|
"D63A","L4","PZA","D","D63",63,"A",0,"MDR","DM","hydrophilic","hydrophobic","acidic","non-polar","neg","non-polar",10.737,-0.769,-0.714,4.4472,-0.704,0.12,40,71,-0.741,8,8,84,0.435233160621762,"loop",-2.13333333333333,3.62,0.0009343107661348,26.7869510135135,26.7869506340703,26.7708032978517,37.2159659891988,2,12,0,0,12,0,0,0,0,4,0,4,6,0,0,0,0,3,0,3,0,0,0,2,1,-0.194782168186423,-0.184496124031008,0.16197670437576,-0.12003410059676,0.0674157303370786,0.421052631578947,-0.610378912685338,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.872,-0.674,"8:7","125/150","W:D:M:G:N:F:Y:E",3.28791485229524,1.90630753051068e-05,0.768996545261043,4.275591187707,7.18677177005967,173.199151011581,1.42792328347145,1.9896368453757e-07,6.70122618511891,5.83859157504838,247.443798048456,1.05744462378296e-09,"lineage4","dr_mutations_pyrazinamide","ALA",0,"ERS457536","ERR551708_ERR551707","lineage4.1.2.1","uz","Nukus","pnca_p.asp63ala","A","-","ASP","DA63","pnca_complex.pdb"
|
|
"D63A","L4","PZA","D","D63",63,"A",NA,"MDR","DM","hydrophilic","hydrophobic","acidic","non-polar","neg","non-polar",10.737,-0.769,-0.714,4.4472,-0.704,0.12,40,71,-0.741,8,8,84,0.435233160621762,"loop",-2.13333333333333,3.62,0.0009343107661348,26.7869510135135,26.7869506340703,26.7708032978517,37.2159659891988,2,12,0,0,12,0,0,0,0,4,0,4,6,0,0,0,0,3,0,3,0,0,0,2,1,-0.194782168186423,-0.184496124031008,0.16197670437576,-0.12003410059676,0.0674157303370786,0.421052631578947,-0.610378912685338,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.872,-0.674,"8:7","125/150","W:D:M:G:N:F:Y:E",3.28791485229524,1.90630753051068e-05,0.768996545261043,4.275591187707,7.18677177005967,173.199151011581,1.42792328347145,1.9896368453757e-07,6.70122618511891,5.83859157504838,247.443798048456,1.05744462378296e-09,"lineage4","dr_mutations_pyrazinamide","ALA",0,"ERR2516502","ERR2516502","lineage4.8","pe","Peru","pnca_p.asp63ala","A","-","ASP","DA63","pnca_complex.pdb"
|
|
"D63A","L2","PZA","D","D63",63,"A",NA,"XDR","DM","hydrophilic","hydrophobic","acidic","non-polar","neg","non-polar",10.737,-0.769,-0.714,4.4472,-0.704,0.12,40,71,-0.741,8,8,84,0.435233160621762,"loop",-2.13333333333333,3.62,0.0009343107661348,26.7869510135135,26.7869506340703,26.7708032978517,37.2159659891988,2,12,0,0,12,0,0,0,0,4,0,4,6,0,0,0,0,3,0,3,0,0,0,2,1,-0.194782168186423,-0.184496124031008,0.16197670437576,-0.12003410059676,0.0674157303370786,0.421052631578947,-0.610378912685338,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.872,-0.674,"8:7","125/150","W:D:M:G:N:F:Y:E",3.28791485229524,1.90630753051068e-05,0.768996545261043,4.275591187707,7.18677177005967,173.199151011581,1.42792328347145,1.9896368453757e-07,6.70122618511891,5.83859157504838,247.443798048456,1.05744462378296e-09,"lineage2","dr_mutations_pyrazinamide","ALA",0,"SRR8791316","SRR8791316","lineage2.2.1","","","pnca_p.asp63ala","A","-","ASP","DA63","pnca_complex.pdb"
|
|
"D63A","L2","PZA","D","D63",63,"A",1,"MDR","DM","hydrophilic","hydrophobic","acidic","non-polar","neg","non-polar",10.737,-0.769,-0.714,4.4472,-0.704,0.12,40,71,-0.741,8,8,84,0.435233160621762,"loop",-2.13333333333333,3.62,0.0009343107661348,26.7869510135135,26.7869506340703,26.7708032978517,37.2159659891988,2,12,0,0,12,0,0,0,0,4,0,4,6,0,0,0,0,3,0,3,0,0,0,2,1,-0.194782168186423,-0.184496124031008,0.16197670437576,-0.12003410059676,0.0674157303370786,0.421052631578947,-0.610378912685338,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.872,-0.674,"8:7","125/150","W:D:M:G:N:F:Y:E",3.28791485229524,1.90630753051068e-05,0.768996545261043,4.275591187707,7.18677177005967,173.199151011581,1.42792328347145,1.9896368453757e-07,6.70122618511891,5.83859157504838,247.443798048456,1.05744462378296e-09,"lineage2","dr_mutations_pyrazinamide","ALA",0,"ERR1035202","ERR1035202","lineage2.2.1","pt","Portugal","pnca_p.asp63ala","A","-","ASP","DA63","pnca_complex.pdb"
|
|
"D63A","L2","PZA","D","D63",63,"A",1,"MDR","DM","hydrophilic","hydrophobic","acidic","non-polar","neg","non-polar",10.737,-0.769,-0.714,4.4472,-0.704,0.12,40,71,-0.741,8,8,84,0.435233160621762,"loop",-2.13333333333333,3.62,0.0009343107661348,26.7869510135135,26.7869506340703,26.7708032978517,37.2159659891988,2,12,0,0,12,0,0,0,0,4,0,4,6,0,0,0,0,3,0,3,0,0,0,2,1,-0.194782168186423,-0.184496124031008,0.16197670437576,-0.12003410059676,0.0674157303370786,0.421052631578947,-0.610378912685338,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.872,-0.674,"8:7","125/150","W:D:M:G:N:F:Y:E",3.28791485229524,1.90630753051068e-05,0.768996545261043,4.275591187707,7.18677177005967,173.199151011581,1.42792328347145,1.9896368453757e-07,6.70122618511891,5.83859157504838,247.443798048456,1.05744462378296e-09,"lineage2","dr_mutations_pyrazinamide","ALA",0,"ERR2864252","ERR2864252","lineage2.2.1","pt","Portugal","pnca_p.asp63ala","A","-","ASP","DA63","pnca_complex.pdb"
|
|
"D63A","L4","PZA","D","D63",63,"A",1,"Pre-MDR","DM","hydrophilic","hydrophobic","acidic","non-polar","neg","non-polar",10.737,-0.769,-0.714,4.4472,-0.704,0.12,40,71,-0.741,8,8,84,0.435233160621762,"loop",-2.13333333333333,3.62,0.0009343107661348,26.7869510135135,26.7869506340703,26.7708032978517,37.2159659891988,2,12,0,0,12,0,0,0,0,4,0,4,6,0,0,0,0,3,0,3,0,0,0,2,1,-0.194782168186423,-0.184496124031008,0.16197670437576,-0.12003410059676,0.0674157303370786,0.421052631578947,-0.610378912685338,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.872,-0.674,"8:7","125/150","W:D:M:G:N:F:Y:E",3.28791485229524,1.90630753051068e-05,0.768996545261043,4.275591187707,7.18677177005967,173.199151011581,1.42792328347145,1.9896368453757e-07,6.70122618511891,5.83859157504838,247.443798048456,1.05744462378296e-09,"lineage4","dr_mutations_pyrazinamide","ALA",0,"ERR2041784","ERR2041784","lineage4.4.1.1","rs","Serbia","pnca_p.asp63ala","A","-","ASP","DA63","pnca_complex.pdb"
|
|
"D63A","L4","PZA","D","D63",63,"A",1,"MDR","DM","hydrophilic","hydrophobic","acidic","non-polar","neg","non-polar",10.737,-0.769,-0.714,4.4472,-0.704,0.12,40,71,-0.741,8,8,84,0.435233160621762,"loop",-2.13333333333333,3.62,0.0009343107661348,26.7869510135135,26.7869506340703,26.7708032978517,37.2159659891988,2,12,0,0,12,0,0,0,0,4,0,4,6,0,0,0,0,3,0,3,0,0,0,2,1,-0.194782168186423,-0.184496124031008,0.16197670437576,-0.12003410059676,0.0674157303370786,0.421052631578947,-0.610378912685338,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.872,-0.674,"8:7","125/150","W:D:M:G:N:F:Y:E",3.28791485229524,1.90630753051068e-05,0.768996545261043,4.275591187707,7.18677177005967,173.199151011581,1.42792328347145,1.9896368453757e-07,6.70122618511891,5.83859157504838,247.443798048456,1.05744462378296e-09,"lineage4","dr_mutations_pyrazinamide","ALA",0,"MDR_11110","SRR6824683","lineage4.4.2","cn","China: Luqiao District, Taizhou City, Zhejiang Province","pnca_p.asp63ala","A","-","ASP","DA63","pnca_complex.pdb"
|
|
"D63E","L2","PZA","D","D63",63,"E",NA,"XDR","OM","hydrophilic","hydrophilic","acidic","acidic","neg","neg",10.737,-0.0139999999999999,-0.219,3.8992,-0.86,0.02,32,66,-0.741,8,8,84,0.435233160621762,"loop",-2.13333333333333,3.62,NA,NA,NA,NA,NA,-4,6,0,0,6,0,0,0,0,4,0,6,2,0,0,0,0,2,0,2,0,0,0,2,2,-0.0035460992907801,-0.0565891472868217,0.142017351524997,-0.146632566069906,0.0112359550561797,0.336842105263158,-0.610378912685338,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.872,-0.674,"8:7","125/150","W:D:M:G:N:F:Y:E",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage2","other_mutations_pyrazinamide","GLU",0,"ERR2515591","ERR2515591","lineage2.2.1","za","South Africa","pnca_p.asp63glu","A","-","ASP","DA63","pnca_complex.pdb"
|
|
"D63E","L2","PZA","D","D63",63,"E",NA,"XDR","OM","hydrophilic","hydrophilic","acidic","acidic","neg","neg",10.737,-0.0139999999999999,-0.219,3.8992,-0.86,0.02,32,66,-0.741,8,8,84,0.435233160621762,"loop",-2.13333333333333,3.62,NA,NA,NA,NA,NA,-4,6,0,0,6,0,0,0,0,4,0,6,2,0,0,0,0,2,0,2,0,0,0,2,2,-0.0035460992907801,-0.0565891472868217,0.142017351524997,-0.146632566069906,0.0112359550561797,0.336842105263158,-0.610378912685338,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.872,-0.674,"8:7","125/150","W:D:M:G:N:F:Y:E",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage2","other_mutations_pyrazinamide","GLU",0,"ERR2515810","ERR2515810","lineage2.2.1","za","South Africa","pnca_p.asp63glu","A","-","ASP","DA63","pnca_complex.pdb"
|
|
"D63G","L2","PZA","D","D63",63,"G",1,"Pre-MDR","DM","hydrophilic","hydrophobic","acidic","neutral","neg","non-polar",10.737,-0.799,-1.153,4.61622,-0.964,-0.66,33,66,-0.741,8,8,84,0.435233160621762,"loop",-2.13333333333333,3.62,0.0005749604714675,4.85515789473684,4.85515785897614,4.85442845338892,4.01139112494925,4,12,0,0,12,0,0,0,0,4,0,4,6,0,0,0,0,3,0,1,0,0,0,7,11,-0.202380952380952,-0.297932816537468,0.168132780687505,-0.164364876385337,-0.172774869109948,0.347368421052632,-0.610378912685338,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.872,-0.674,"8:7","125/150","W:D:M:G:N:F:Y:E",1.58004161593687,0.0255237229775361,0.70746570614631,2.23338262506551,1.14726850666831,20.5466864308595,0.686203358177678,0.033386534669467,1.47642865587913,0.903495684237988,26.0627135254866,0.0451938468216249,"lineage2","dr_mutations_pyrazinamide","GLY",0,"SRR6369875","SRR6369875","lineage2.2.1","au","Australia","pnca_p.asp63gly","A","-","ASP","DA63","pnca_complex.pdb"
|
|
"D63G","L4","PZA","D","D63",63,"G",0,"MDR","DM","hydrophilic","hydrophobic","acidic","neutral","neg","non-polar",10.737,-0.799,-1.153,4.61622,-0.964,-0.66,33,66,-0.741,8,8,84,0.435233160621762,"loop",-2.13333333333333,3.62,0.0005749604714675,4.85515789473684,4.85515785897614,4.85442845338892,4.01139112494925,4,12,0,0,12,0,0,0,0,4,0,4,6,0,0,0,0,3,0,1,0,0,0,7,11,-0.202380952380952,-0.297932816537468,0.168132780687505,-0.164364876385337,-0.172774869109948,0.347368421052632,-0.610378912685338,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.872,-0.674,"8:7","125/150","W:D:M:G:N:F:Y:E",1.58004161593687,0.0255237229775361,0.70746570614631,2.23338262506551,1.14726850666831,20.5466864308595,0.686203358177678,0.033386534669467,1.47642865587913,0.903495684237988,26.0627135254866,0.0451938468216249,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR2517075","ERR2517075","lineage4.3.3","gb","UK","pnca_p.asp63gly","A","-","ASP","DA63","pnca_complex.pdb"
|
|
"D63G","L2","PZA","D","D63",63,"G",NA,"MDR","DM","hydrophilic","hydrophobic","acidic","neutral","neg","non-polar",10.737,-0.799,-1.153,4.61622,-0.964,-0.66,33,66,-0.741,8,8,84,0.435233160621762,"loop",-2.13333333333333,3.62,0.0005749604714675,4.85515789473684,4.85515785897614,4.85442845338892,4.01139112494925,4,12,0,0,12,0,0,0,0,4,0,4,6,0,0,0,0,3,0,1,0,0,0,7,11,-0.202380952380952,-0.297932816537468,0.168132780687505,-0.164364876385337,-0.172774869109948,0.347368421052632,-0.610378912685338,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.872,-0.674,"8:7","125/150","W:D:M:G:N:F:Y:E",1.58004161593687,0.0255237229775361,0.70746570614631,2.23338262506551,1.14726850666831,20.5466864308595,0.686203358177678,0.033386534669467,1.47642865587913,0.903495684237988,26.0627135254866,0.0451938468216249,"lineage2","dr_mutations_pyrazinamide","GLY",0,"SAMN02414936","SRR1146290_SRR1163078_SRR1144762_SRR1163478","lineage2.2.1","se","Sweden","pnca_p.asp63gly","A","-","ASP","DA63","pnca_complex.pdb"
|
|
"D63G","L2","PZA","D","D63",63,"G",NA,"MDR","DM","hydrophilic","hydrophobic","acidic","neutral","neg","non-polar",10.737,-0.799,-1.153,4.61622,-0.964,-0.66,33,66,-0.741,8,8,84,0.435233160621762,"loop",-2.13333333333333,3.62,0.0005749604714675,4.85515789473684,4.85515785897614,4.85442845338892,4.01139112494925,4,12,0,0,12,0,0,0,0,4,0,4,6,0,0,0,0,3,0,1,0,0,0,7,11,-0.202380952380952,-0.297932816537468,0.168132780687505,-0.164364876385337,-0.172774869109948,0.347368421052632,-0.610378912685338,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.872,-0.674,"8:7","125/150","W:D:M:G:N:F:Y:E",1.58004161593687,0.0255237229775361,0.70746570614631,2.23338262506551,1.14726850666831,20.5466864308595,0.686203358177678,0.033386534669467,1.47642865587913,0.903495684237988,26.0627135254866,0.0451938468216249,"lineage2","dr_mutations_pyrazinamide","GLY",0,"ERR1023415","ERR1023415","lineage2.2.1","","","pnca_p.asp63gly","A","-","ASP","DA63","pnca_complex.pdb"
|
|
"D63G","L3","PZA","D","D63",63,"G",1,"Pre-MDR","DM","hydrophilic","hydrophobic","acidic","neutral","neg","non-polar",10.737,-0.799,-1.153,4.61622,-0.964,-0.66,33,66,-0.741,8,8,84,0.435233160621762,"loop",-2.13333333333333,3.62,0.0005749604714675,4.85515789473684,4.85515785897614,4.85442845338892,4.01139112494925,4,12,0,0,12,0,0,0,0,4,0,4,6,0,0,0,0,3,0,1,0,0,0,7,11,-0.202380952380952,-0.297932816537468,0.168132780687505,-0.164364876385337,-0.172774869109948,0.347368421052632,-0.610378912685338,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.872,-0.674,"8:7","125/150","W:D:M:G:N:F:Y:E",1.58004161593687,0.0255237229775361,0.70746570614631,2.23338262506551,1.14726850666831,20.5466864308595,0.686203358177678,0.033386534669467,1.47642865587913,0.903495684237988,26.0627135254866,0.0451938468216249,"lineage3","dr_mutations_pyrazinamide","GLY",0,"ERR2510476","ERR2510476","lineage3","pk","Pakistan","pnca_p.asp63gly","A","-","ASP","DA63","pnca_complex.pdb"
|
|
"D63G","L1","PZA","D","D63",63,"G",NA,"MDR","DM","hydrophilic","hydrophobic","acidic","neutral","neg","non-polar",10.737,-0.799,-1.153,4.61622,-0.964,-0.66,33,66,-0.741,8,8,84,0.435233160621762,"loop",-2.13333333333333,3.62,0.0005749604714675,4.85515789473684,4.85515785897614,4.85442845338892,4.01139112494925,4,12,0,0,12,0,0,0,0,4,0,4,6,0,0,0,0,3,0,1,0,0,0,7,11,-0.202380952380952,-0.297932816537468,0.168132780687505,-0.164364876385337,-0.172774869109948,0.347368421052632,-0.610378912685338,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.872,-0.674,"8:7","125/150","W:D:M:G:N:F:Y:E",1.58004161593687,0.0255237229775361,0.70746570614631,2.23338262506551,1.14726850666831,20.5466864308595,0.686203358177678,0.033386534669467,1.47642865587913,0.903495684237988,26.0627135254866,0.0451938468216249,"lineage1","dr_mutations_pyrazinamide","GLY",0,"SRR7898217","SRR7898217","lineage1.1.2","in","India","pnca_p.asp63gly","A","-","ASP","DA63","pnca_complex.pdb"
|
|
"D63G","L4","PZA","D","D63",63,"G",0,"MDR","DM","hydrophilic","hydrophobic","acidic","neutral","neg","non-polar",10.737,-0.799,-1.153,4.61622,-0.964,-0.66,33,66,-0.741,8,8,84,0.435233160621762,"loop",-2.13333333333333,3.62,0.0005749604714675,4.85515789473684,4.85515785897614,4.85442845338892,4.01139112494925,4,12,0,0,12,0,0,0,0,4,0,4,6,0,0,0,0,3,0,1,0,0,0,7,11,-0.202380952380952,-0.297932816537468,0.168132780687505,-0.164364876385337,-0.172774869109948,0.347368421052632,-0.610378912685338,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.872,-0.674,"8:7","125/150","W:D:M:G:N:F:Y:E",1.58004161593687,0.0255237229775361,0.70746570614631,2.23338262506551,1.14726850666831,20.5466864308595,0.686203358177678,0.033386534669467,1.47642865587913,0.903495684237988,26.0627135254866,0.0451938468216249,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR2514503","ERR2514503","lineage4.3.3","gb","UK","pnca_p.asp63gly","A","-","ASP","DA63","pnca_complex.pdb"
|
|
"D63G","L2","PZA","D","D63",63,"G",0,"Pre-XDR","DM","hydrophilic","hydrophobic","acidic","neutral","neg","non-polar",10.737,-0.799,-1.153,4.61622,-0.964,-0.66,33,66,-0.741,8,8,84,0.435233160621762,"loop",-2.13333333333333,3.62,0.0005749604714675,4.85515789473684,4.85515785897614,4.85442845338892,4.01139112494925,4,12,0,0,12,0,0,0,0,4,0,4,6,0,0,0,0,3,0,1,0,0,0,7,11,-0.202380952380952,-0.297932816537468,0.168132780687505,-0.164364876385337,-0.172774869109948,0.347368421052632,-0.610378912685338,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.872,-0.674,"8:7","125/150","W:D:M:G:N:F:Y:E",1.58004161593687,0.0255237229775361,0.70746570614631,2.23338262506551,1.14726850666831,20.5466864308595,0.686203358177678,0.033386534669467,1.47642865587913,0.903495684237988,26.0627135254866,0.0451938468216249,"lineage2","dr_mutations_pyrazinamide","GLY",0,"ERR2516905","ERR2516905","lineage2.2.1.1","gb","UK","pnca_p.asp63gly","A","-","ASP","DA63","pnca_complex.pdb"
|
|
"D63G","L4","PZA","D","D63",63,"G",0,"MDR","DM","hydrophilic","hydrophobic","acidic","neutral","neg","non-polar",10.737,-0.799,-1.153,4.61622,-0.964,-0.66,33,66,-0.741,8,8,84,0.435233160621762,"loop",-2.13333333333333,3.62,0.0005749604714675,4.85515789473684,4.85515785897614,4.85442845338892,4.01139112494925,4,12,0,0,12,0,0,0,0,4,0,4,6,0,0,0,0,3,0,1,0,0,0,7,11,-0.202380952380952,-0.297932816537468,0.168132780687505,-0.164364876385337,-0.172774869109948,0.347368421052632,-0.610378912685338,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.872,-0.674,"8:7","125/150","W:D:M:G:N:F:Y:E",1.58004161593687,0.0255237229775361,0.70746570614631,2.23338262506551,1.14726850666831,20.5466864308595,0.686203358177678,0.033386534669467,1.47642865587913,0.903495684237988,26.0627135254866,0.0451938468216249,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR2516715","ERR2516715","lineage4.2.2.1","nl","Netherlands","pnca_p.asp63gly","A","-","ASP","DA63","pnca_complex.pdb"
|
|
"D63G","L4","PZA","D","D63",63,"G",NA,"MDR","DM","hydrophilic","hydrophobic","acidic","neutral","neg","non-polar",10.737,-0.799,-1.153,4.61622,-0.964,-0.66,33,66,-0.741,8,8,84,0.435233160621762,"loop",-2.13333333333333,3.62,0.0005749604714675,4.85515789473684,4.85515785897614,4.85442845338892,4.01139112494925,4,12,0,0,12,0,0,0,0,4,0,4,6,0,0,0,0,3,0,1,0,0,0,7,11,-0.202380952380952,-0.297932816537468,0.168132780687505,-0.164364876385337,-0.172774869109948,0.347368421052632,-0.610378912685338,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.872,-0.674,"8:7","125/150","W:D:M:G:N:F:Y:E",1.58004161593687,0.0255237229775361,0.70746570614631,2.23338262506551,1.14726850666831,20.5466864308595,0.686203358177678,0.033386534669467,1.47642865587913,0.903495684237988,26.0627135254866,0.0451938468216249,"lineage4","dr_mutations_pyrazinamide","GLY",0,"SAMN02381010","SRR1062898_SRR1049625_SRR1049624_SRR1140750","lineage4.3.4.2.1","ug","Uganda","pnca_p.asp63gly","A","-","ASP","DA63","pnca_complex.pdb"
|
|
"D63G","L4","PZA","D","D63",63,"G",NA,"MDR","DM","hydrophilic","hydrophobic","acidic","neutral","neg","non-polar",10.737,-0.799,-1.153,4.61622,-0.964,-0.66,33,66,-0.741,8,8,84,0.435233160621762,"loop",-2.13333333333333,3.62,0.0005749604714675,4.85515789473684,4.85515785897614,4.85442845338892,4.01139112494925,4,12,0,0,12,0,0,0,0,4,0,4,6,0,0,0,0,3,0,1,0,0,0,7,11,-0.202380952380952,-0.297932816537468,0.168132780687505,-0.164364876385337,-0.172774869109948,0.347368421052632,-0.610378912685338,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.872,-0.674,"8:7","125/150","W:D:M:G:N:F:Y:E",1.58004161593687,0.0255237229775361,0.70746570614631,2.23338262506551,1.14726850666831,20.5466864308595,0.686203358177678,0.033386534669467,1.47642865587913,0.903495684237988,26.0627135254866,0.0451938468216249,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR2707192","ERR2707192","lineage4.3.4.2","cd","Democratic Republic of Congo","pnca_p.asp63gly","A","-","ASP","DA63","pnca_complex.pdb"
|
|
"D63G","L4","PZA","D","D63",63,"G",NA,"MDR","DM","hydrophilic","hydrophobic","acidic","neutral","neg","non-polar",10.737,-0.799,-1.153,4.61622,-0.964,-0.66,33,66,-0.741,8,8,84,0.435233160621762,"loop",-2.13333333333333,3.62,0.0005749604714675,4.85515789473684,4.85515785897614,4.85442845338892,4.01139112494925,4,12,0,0,12,0,0,0,0,4,0,4,6,0,0,0,0,3,0,1,0,0,0,7,11,-0.202380952380952,-0.297932816537468,0.168132780687505,-0.164364876385337,-0.172774869109948,0.347368421052632,-0.610378912685338,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.872,-0.674,"8:7","125/150","W:D:M:G:N:F:Y:E",1.58004161593687,0.0255237229775361,0.70746570614631,2.23338262506551,1.14726850666831,20.5466864308595,0.686203358177678,0.033386534669467,1.47642865587913,0.903495684237988,26.0627135254866,0.0451938468216249,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR2706995","ERR2706995","lineage4.3.4.2","cd","Democratic Republic of Congo","pnca_p.asp63gly","A","-","ASP","DA63","pnca_complex.pdb"
|
|
"D63G","L2","PZA","D","D63",63,"G",1,"Pre-XDR","DM","hydrophilic","hydrophobic","acidic","neutral","neg","non-polar",10.737,-0.799,-1.153,4.61622,-0.964,-0.66,33,66,-0.741,8,8,84,0.435233160621762,"loop",-2.13333333333333,3.62,0.0005749604714675,4.85515789473684,4.85515785897614,4.85442845338892,4.01139112494925,4,12,0,0,12,0,0,0,0,4,0,4,6,0,0,0,0,3,0,1,0,0,0,7,11,-0.202380952380952,-0.297932816537468,0.168132780687505,-0.164364876385337,-0.172774869109948,0.347368421052632,-0.610378912685338,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.872,-0.674,"8:7","125/150","W:D:M:G:N:F:Y:E",1.58004161593687,0.0255237229775361,0.70746570614631,2.23338262506551,1.14726850666831,20.5466864308595,0.686203358177678,0.033386534669467,1.47642865587913,0.903495684237988,26.0627135254866,0.0451938468216249,"lineage2","dr_mutations_pyrazinamide","GLY",0,"SAMN10961391","SRR8651663","lineage2.2.1","cn","China:Wenzhou","pnca_p.asp63gly","A","-","ASP","DA63","pnca_complex.pdb"
|
|
"D63G","L4","PZA","D","D63",63,"G",1,"MDR","DM","hydrophilic","hydrophobic","acidic","neutral","neg","non-polar",10.737,-0.799,-1.153,4.61622,-0.964,-0.66,33,66,-0.741,8,8,84,0.435233160621762,"loop",-2.13333333333333,3.62,0.0005749604714675,4.85515789473684,4.85515785897614,4.85442845338892,4.01139112494925,4,12,0,0,12,0,0,0,0,4,0,4,6,0,0,0,0,3,0,1,0,0,0,7,11,-0.202380952380952,-0.297932816537468,0.168132780687505,-0.164364876385337,-0.172774869109948,0.347368421052632,-0.610378912685338,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.872,-0.674,"8:7","125/150","W:D:M:G:N:F:Y:E",1.58004161593687,0.0255237229775361,0.70746570614631,2.23338262506551,1.14726850666831,20.5466864308595,0.686203358177678,0.033386534669467,1.47642865587913,0.903495684237988,26.0627135254866,0.0451938468216249,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR038744","ERR038744","lineage4.3.4.2.1","ug","Uganda","pnca_p.asp63gly","A","-","ASP","DA63","pnca_complex.pdb"
|
|
"D63H","L3","PZA","D","D63",63,"H",0,"XDR","DM","hydrophilic","hydrophobic","acidic","basic","neg","pos",10.737,-0.456,-0.085,4.09043,-0.703,0.25,35,66,-0.741,8,8,84,0.435233160621762,"loop",-2.13333333333333,3.62,0.0002156101768003,2.42493692178301,2.42493957425811,2.42473736947533,4.31445715363782e-25,-4,6,0,0,6,0,0,0,0,2,0,2,6,0,0,0,0,3,0,3,0,0,0,2,-2,-0.115501519756839,-0.0219638242894056,0.148982364382025,-0.119863597612958,0.140449438202247,0.368421052631579,-0.610378912685338,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.872,-0.674,"8:7","125/150","W:D:M:G:N:F:Y:E",0.885806606247284,0.469406216824826,1.22442753211922,0.723445514749363,0.112662937620386,25.3270547471305,0.384700446081433,0.430258985168156,0.366270051463612,0.0410854444106247,46.5881472867033,0.999999999999476,"lineage3","dr_mutations_pyrazinamide","HIS",0,"ERR2510422","ERR2510422","lineage3","pk","Pakistan","pnca_p.asp63his","A","-","ASP","DA63","pnca_complex.pdb"
|
|
"D63H","L4","PZA","D","D63",63,"H",NA,"Pre-XDR","DM","hydrophilic","hydrophobic","acidic","basic","neg","pos",10.737,-0.456,-0.085,4.09043,-0.703,0.25,35,66,-0.741,8,8,84,0.435233160621762,"loop",-2.13333333333333,3.62,0.0002156101768003,2.42493692178301,2.42493957425811,2.42473736947533,4.31445715363782e-25,-4,6,0,0,6,0,0,0,0,2,0,2,6,0,0,0,0,3,0,3,0,0,0,2,-2,-0.115501519756839,-0.0219638242894056,0.148982364382025,-0.119863597612958,0.140449438202247,0.368421052631579,-0.610378912685338,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.872,-0.674,"8:7","125/150","W:D:M:G:N:F:Y:E",0.885806606247284,0.469406216824826,1.22442753211922,0.723445514749363,0.112662937620386,25.3270547471305,0.384700446081433,0.430258985168156,0.366270051463612,0.0410854444106247,46.5881472867033,0.999999999999476,"lineage4","dr_mutations_pyrazinamide","HIS",0,"ERR1035315","ERR1035315","lineage4.3.4.1","br","Brazil","pnca_p.asp63his","A","-","ASP","DA63","pnca_complex.pdb"
|
|
"D63H","L3","PZA","D","D63",63,"H",1,"MDR","DM","hydrophilic","hydrophobic","acidic","basic","neg","pos",10.737,-0.456,-0.085,4.09043,-0.703,0.25,35,66,-0.741,8,8,84,0.435233160621762,"loop",-2.13333333333333,3.62,0.0002156101768003,2.42493692178301,2.42493957425811,2.42473736947533,4.31445715363782e-25,-4,6,0,0,6,0,0,0,0,2,0,2,6,0,0,0,0,3,0,3,0,0,0,2,-2,-0.115501519756839,-0.0219638242894056,0.148982364382025,-0.119863597612958,0.140449438202247,0.368421052631579,-0.610378912685338,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.872,-0.674,"8:7","125/150","W:D:M:G:N:F:Y:E",0.885806606247284,0.469406216824826,1.22442753211922,0.723445514749363,0.112662937620386,25.3270547471305,0.384700446081433,0.430258985168156,0.366270051463612,0.0410854444106247,46.5881472867033,0.999999999999476,"lineage3","dr_mutations_pyrazinamide","HIS",0,"ERR2510297","ERR2510297","lineage3","pk","Pakistan","pnca_p.asp63his","A","-","ASP","DA63","pnca_complex.pdb"
|
|
"D63H","L5","PZA","D","D63",63,"H",NA,"Pre-MDR","DM","hydrophilic","hydrophobic","acidic","basic","neg","pos",10.737,-0.456,-0.085,4.09043,-0.703,0.25,35,66,-0.741,8,8,84,0.435233160621762,"loop",-2.13333333333333,3.62,0.0002156101768003,2.42493692178301,2.42493957425811,2.42473736947533,4.31445715363782e-25,-4,6,0,0,6,0,0,0,0,2,0,2,6,0,0,0,0,3,0,3,0,0,0,2,-2,-0.115501519756839,-0.0219638242894056,0.148982364382025,-0.119863597612958,0.140449438202247,0.368421052631579,-0.610378912685338,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.872,-0.674,"8:7","125/150","W:D:M:G:N:F:Y:E",0.885806606247284,0.469406216824826,1.22442753211922,0.723445514749363,0.112662937620386,25.3270547471305,0.384700446081433,0.430258985168156,0.366270051463612,0.0410854444106247,46.5881472867033,0.999999999999476,"lineage5","dr_mutations_pyrazinamide","HIS",0,"ERR3170440","ERR3170440","lineage5","gh","Ghana","pnca_p.asp63his","A","-","ASP","DA63","pnca_complex.pdb"
|
|
"D63H","L2","PZA","D","D63",63,"H",NA,"MDR","DM","hydrophilic","hydrophobic","acidic","basic","neg","pos",10.737,-0.456,-0.085,4.09043,-0.703,0.25,35,66,-0.741,8,8,84,0.435233160621762,"loop",-2.13333333333333,3.62,0.0002156101768003,2.42493692178301,2.42493957425811,2.42473736947533,4.31445715363782e-25,-4,6,0,0,6,0,0,0,0,2,0,2,6,0,0,0,0,3,0,3,0,0,0,2,-2,-0.115501519756839,-0.0219638242894056,0.148982364382025,-0.119863597612958,0.140449438202247,0.368421052631579,-0.610378912685338,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.872,-0.674,"8:7","125/150","W:D:M:G:N:F:Y:E",0.885806606247284,0.469406216824826,1.22442753211922,0.723445514749363,0.112662937620386,25.3270547471305,0.384700446081433,0.430258985168156,0.366270051463612,0.0410854444106247,46.5881472867033,0.999999999999476,"lineage2","dr_mutations_pyrazinamide","HIS",0,"SRR1710108","SRR1710108","lineage2.2.1","cn","","pnca_p.asp63his","A","-","ASP","DA63","pnca_complex.pdb"
|
|
"D63H","L4","PZA","D","D63",63,"H",NA,"Pre-XDR","DM","hydrophilic","hydrophobic","acidic","basic","neg","pos",10.737,-0.456,-0.085,4.09043,-0.703,0.25,35,66,-0.741,8,8,84,0.435233160621762,"loop",-2.13333333333333,3.62,0.0002156101768003,2.42493692178301,2.42493957425811,2.42473736947533,4.31445715363782e-25,-4,6,0,0,6,0,0,0,0,2,0,2,6,0,0,0,0,3,0,3,0,0,0,2,-2,-0.115501519756839,-0.0219638242894056,0.148982364382025,-0.119863597612958,0.140449438202247,0.368421052631579,-0.610378912685338,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.872,-0.674,"8:7","125/150","W:D:M:G:N:F:Y:E",0.885806606247284,0.469406216824826,1.22442753211922,0.723445514749363,0.112662937620386,25.3270547471305,0.384700446081433,0.430258985168156,0.366270051463612,0.0410854444106247,46.5881472867033,0.999999999999476,"lineage4","dr_mutations_pyrazinamide","HIS",0,"ERR1035318","ERR1035318","lineage4.3.4.1","br","Brazil","pnca_p.asp63his","A","-","ASP","DA63","pnca_complex.pdb"
|
|
"D63H","L4","PZA","D","D63",63,"H",NA,"XDR","DM","hydrophilic","hydrophobic","acidic","basic","neg","pos",10.737,-0.456,-0.085,4.09043,-0.703,0.25,35,66,-0.741,8,8,84,0.435233160621762,"loop",-2.13333333333333,3.62,0.0002156101768003,2.42493692178301,2.42493957425811,2.42473736947533,4.31445715363782e-25,-4,6,0,0,6,0,0,0,0,2,0,2,6,0,0,0,0,3,0,3,0,0,0,2,-2,-0.115501519756839,-0.0219638242894056,0.148982364382025,-0.119863597612958,0.140449438202247,0.368421052631579,-0.610378912685338,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.872,-0.674,"8:7","125/150","W:D:M:G:N:F:Y:E",0.885806606247284,0.469406216824826,1.22442753211922,0.723445514749363,0.112662937620386,25.3270547471305,0.384700446081433,0.430258985168156,0.366270051463612,0.0410854444106247,46.5881472867033,0.999999999999476,"lineage4","dr_mutations_pyrazinamide","HIS",0,"ERR1035266","ERR1035266","lineage4.3.4.1","br","Brazil","pnca_p.asp63his","A","-","ASP","DA63","pnca_complex.pdb"
|
|
"D63H","L4","PZA","D","D63",63,"H",NA,"Pre-XDR","DM","hydrophilic","hydrophobic","acidic","basic","neg","pos",10.737,-0.456,-0.085,4.09043,-0.703,0.25,35,66,-0.741,8,8,84,0.435233160621762,"loop",-2.13333333333333,3.62,0.0002156101768003,2.42493692178301,2.42493957425811,2.42473736947533,4.31445715363782e-25,-4,6,0,0,6,0,0,0,0,2,0,2,6,0,0,0,0,3,0,3,0,0,0,2,-2,-0.115501519756839,-0.0219638242894056,0.148982364382025,-0.119863597612958,0.140449438202247,0.368421052631579,-0.610378912685338,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.872,-0.674,"8:7","125/150","W:D:M:G:N:F:Y:E",0.885806606247284,0.469406216824826,1.22442753211922,0.723445514749363,0.112662937620386,25.3270547471305,0.384700446081433,0.430258985168156,0.366270051463612,0.0410854444106247,46.5881472867033,0.999999999999476,"lineage4","dr_mutations_pyrazinamide","HIS",0,"ERR1035321","ERR1035321","lineage4.3.4.1","br","Brazil","pnca_p.asp63his","A","-","ASP","DA63","pnca_complex.pdb"
|
|
"D63H","L4","PZA","D","D63",63,"H",NA,"MDR","DM","hydrophilic","hydrophobic","acidic","basic","neg","pos",10.737,-0.456,-0.085,4.09043,-0.703,0.25,35,66,-0.741,8,8,84,0.435233160621762,"loop",-2.13333333333333,3.62,0.0002156101768003,2.42493692178301,2.42493957425811,2.42473736947533,4.31445715363782e-25,-4,6,0,0,6,0,0,0,0,2,0,2,6,0,0,0,0,3,0,3,0,0,0,2,-2,-0.115501519756839,-0.0219638242894056,0.148982364382025,-0.119863597612958,0.140449438202247,0.368421052631579,-0.610378912685338,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.872,-0.674,"8:7","125/150","W:D:M:G:N:F:Y:E",0.885806606247284,0.469406216824826,1.22442753211922,0.723445514749363,0.112662937620386,25.3270547471305,0.384700446081433,0.430258985168156,0.366270051463612,0.0410854444106247,46.5881472867033,0.999999999999476,"lineage4","dr_mutations_pyrazinamide","HIS",0,"ERR1035322","ERR1035322","lineage4.3.4.1","br","Brazil","pnca_p.asp63his","A","-","ASP","DA63","pnca_complex.pdb"
|
|
"D63H","L3","PZA","D","D63",63,"H",0,"Pre-XDR","DM","hydrophilic","hydrophobic","acidic","basic","neg","pos",10.737,-0.456,-0.085,4.09043,-0.703,0.25,35,66,-0.741,8,8,84,0.435233160621762,"loop",-2.13333333333333,3.62,0.0002156101768003,2.42493692178301,2.42493957425811,2.42473736947533,4.31445715363782e-25,-4,6,0,0,6,0,0,0,0,2,0,2,6,0,0,0,0,3,0,3,0,0,0,2,-2,-0.115501519756839,-0.0219638242894056,0.148982364382025,-0.119863597612958,0.140449438202247,0.368421052631579,-0.610378912685338,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.872,-0.674,"8:7","125/150","W:D:M:G:N:F:Y:E",0.885806606247284,0.469406216824826,1.22442753211922,0.723445514749363,0.112662937620386,25.3270547471305,0.384700446081433,0.430258985168156,0.366270051463612,0.0410854444106247,46.5881472867033,0.999999999999476,"lineage3","dr_mutations_pyrazinamide","HIS",0,"ERR2510445","ERR2510445","lineage3","pk","Pakistan","pnca_p.asp63his","A","-","ASP","DA63","pnca_complex.pdb"
|
|
"D63H","L4","PZA","D","D63",63,"H",NA,"Pre-XDR","DM","hydrophilic","hydrophobic","acidic","basic","neg","pos",10.737,-0.456,-0.085,4.09043,-0.703,0.25,35,66,-0.741,8,8,84,0.435233160621762,"loop",-2.13333333333333,3.62,0.0002156101768003,2.42493692178301,2.42493957425811,2.42473736947533,4.31445715363782e-25,-4,6,0,0,6,0,0,0,0,2,0,2,6,0,0,0,0,3,0,3,0,0,0,2,-2,-0.115501519756839,-0.0219638242894056,0.148982364382025,-0.119863597612958,0.140449438202247,0.368421052631579,-0.610378912685338,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.872,-0.674,"8:7","125/150","W:D:M:G:N:F:Y:E",0.885806606247284,0.469406216824826,1.22442753211922,0.723445514749363,0.112662937620386,25.3270547471305,0.384700446081433,0.430258985168156,0.366270051463612,0.0410854444106247,46.5881472867033,0.999999999999476,"lineage4","dr_mutations_pyrazinamide","HIS",0,"ERR1035288","ERR1035288","lineage4.3.4.1","br","Brazil","pnca_p.asp63his","A","-","ASP","DA63","pnca_complex.pdb"
|
|
"D63V","L4","PZA","D","D63",63,"V",NA,"MDR","OM","hydrophilic","hydrophobic","acidic","non-polar","neg","non-polar",10.737,-0.722,0.0279999999999999,4.48687,-0.842,-0.12,40,71,-0.741,8,8,84,0.435233160621762,"loop",-2.13333333333333,3.62,NA,NA,NA,NA,NA,0,12,0,0,12,0,0,0,0,4,0,4,6,0,0,0,0,1,0,1,0,0,0,0,0,-0.182877406281662,0.0238095238095238,0.163421572126837,-0.143563512361466,-0.031413612565445,0.421052631578947,-0.610378912685338,"Destabilising","Stabilising","Destabilising","Destabilising","Destabilising","effect",-0.872,-0.674,"8:7","125/150","W:D:M:G:N:F:Y:E",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage4","other_mutations_pyrazinamide","VAL",0,"SAMN02584627","SRR1166318_SRR1169048","lineage4.3.3","md","Moldova","pnca_p.asp63val","A","-","ASP","DA63","pnca_complex.pdb"
|
|
"D63Y","L2","PZA","D","D63",63,"Y",NA,"XDR","OM","hydrophilic","hydrophobic","acidic","neutral","neg","polar",10.737,-0.438,0.07,4.37717,-0.53,0.23,35,66,-0.741,8,8,84,0.435233160621762,"loop",-2.13333333333333,3.62,7.18700589334483e-05,2.42412778478352,0.0001249735077034,0,1.03410070803344e-29,-6,12,0,0,12,0,0,0,0,4,0,4,6,0,0,0,0,2,0,2,-2,0,0,2,0,-0.110942249240121,0.0595238095238095,0.15942605933901,-0.0903665814151748,0.129213483146067,0.368421052631579,-0.610378912685338,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-0.872,-0.674,"8:7","125/150","W:D:M:G:N:F:Y:E",-8.98740878149641,0.940032862253634,119.468044435492,-0.0752285585987744,NA,4692673.51081431,0.384555509373631,1,0,0,188.544222231268,0.999999999999997,"lineage2","other_mutations_pyrazinamide","TYR",0,"SAMN02360617","SRR1049071_SRR1013674_SRR1013675_SRR1049070","lineage2.2.2","kr","South Korea","pnca_p.asp63tyr","A","-","ASP","DA63","pnca_complex.pdb"
|
|
"D63Y","L2","PZA","D","D63",63,"Y",NA,"MDR","OM","hydrophilic","hydrophobic","acidic","neutral","neg","polar",10.737,-0.438,0.07,4.37717,-0.53,0.23,35,66,-0.741,8,8,84,0.435233160621762,"loop",-2.13333333333333,3.62,7.18700589334483e-05,2.42412778478352,0.0001249735077034,0,1.03410070803344e-29,-6,12,0,0,12,0,0,0,0,4,0,4,6,0,0,0,0,2,0,2,-2,0,0,2,0,-0.110942249240121,0.0595238095238095,0.15942605933901,-0.0903665814151748,0.129213483146067,0.368421052631579,-0.610378912685338,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-0.872,-0.674,"8:7","125/150","W:D:M:G:N:F:Y:E",-8.98740878149641,0.940032862253634,119.468044435492,-0.0752285585987744,NA,4692673.51081431,0.384555509373631,1,0,0,188.544222231268,0.999999999999997,"lineage2","other_mutations_pyrazinamide","TYR",0,"SRS796943","SRR1723425","lineage2.2.2","cn","China:Liaoning","pnca_p.asp63tyr","A","-","ASP","DA63","pnca_complex.pdb"
|
|
"D63Y","L2","PZA","D","D63",63,"Y",0,"MDR","OM","hydrophilic","hydrophobic","acidic","neutral","neg","polar",10.737,-0.438,0.07,4.37717,-0.53,0.23,35,66,-0.741,8,8,84,0.435233160621762,"loop",-2.13333333333333,3.62,7.18700589334483e-05,2.42412778478352,0.0001249735077034,0,1.03410070803344e-29,-6,12,0,0,12,0,0,0,0,4,0,4,6,0,0,0,0,2,0,2,-2,0,0,2,0,-0.110942249240121,0.0595238095238095,0.15942605933901,-0.0903665814151748,0.129213483146067,0.368421052631579,-0.610378912685338,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-0.872,-0.674,"8:7","125/150","W:D:M:G:N:F:Y:E",-8.98740878149641,0.940032862253634,119.468044435492,-0.0752285585987744,NA,4692673.51081431,0.384555509373631,1,0,0,188.544222231268,0.999999999999997,"lineage2","other_mutations_pyrazinamide","TYR",0,"MDR_6113","SRR6824472","lineage2.2.2","cn","China: Liaoyang City, Liaoning Province","pnca_p.asp63tyr","A","-","ASP","DA63","pnca_complex.pdb"
|
|
"Y64D","L2","PZA","Y","Y64",64,"D",0,"MDR","DM","hydrophobic","hydrophilic","neutral","acidic","polar","neg",8.434,0.546,-0.392,2.59866,-0.33,0.17,69,80,0.947,1,1,135,0.513307984790874,"loop",-1.86666666666667,3.61,0.0002874802357337,4.85191417753471,4.85191414039982,4.85118443551178,1.17497090855698,32,-18,0,0,-18,0,0,0,0,0,0,0,0,0,0,0,0,3,0,-3,4,6,0,6,4,0.244843049327354,-0.101291989664083,0.0946488537940982,-0.0562659846547315,0.0955056179775281,0.726315789473684,0.303525641025641,"Stabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",0.59,1.183,"3:1","146/150","E:Y:H:F:Q:N:R:K:S:G:A:T:P:W:D",1.57937329521209,0.114342297004304,1.0002536454007,1.57897279602454,0.581889091311512,40.4562911075298,0.685913110299906,0.137954936368295,0.860262754777729,0.351471331417763,67.0421060419706,0.278382201819561,"lineage2","dr_mutations_pyrazinamide","ASP",0,"ERS457793","ERR552068_ERR552067","lineage2.2.1","uz","Nukus","pnca_p.tyr64asp","A","S","TYR","YA64","pnca_complex.pdb"
|
|
"Y64D","L4","PZA","Y","Y64",64,"D",1,"MDR","DM","hydrophobic","hydrophilic","neutral","acidic","polar","neg",8.434,0.546,-0.392,2.59866,-0.33,0.17,69,80,0.947,1,1,135,0.513307984790874,"loop",-1.86666666666667,3.61,0.0002874802357337,4.85191417753471,4.85191414039982,4.85118443551178,1.17497090855698,32,-18,0,0,-18,0,0,0,0,0,0,0,0,0,0,0,0,3,0,-3,4,6,0,6,4,0.244843049327354,-0.101291989664083,0.0946488537940982,-0.0562659846547315,0.0955056179775281,0.726315789473684,0.303525641025641,"Stabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",0.59,1.183,"3:1","146/150","E:Y:H:F:Q:N:R:K:S:G:A:T:P:W:D",1.57937329521209,0.114342297004304,1.0002536454007,1.57897279602454,0.581889091311512,40.4562911075298,0.685913110299906,0.137954936368295,0.860262754777729,0.351471331417763,67.0421060419706,0.278382201819561,"lineage4","dr_mutations_pyrazinamide","ASP",0,"ERR2864217","ERR2864217","lineage4.3.4.1","pt","Portugal","pnca_p.tyr64asp","A","S","TYR","YA64","pnca_complex.pdb"
|
|
"Y64D","L4","PZA","Y","Y64",64,"D",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","neutral","acidic","polar","neg",8.434,0.546,-0.392,2.59866,-0.33,0.17,69,80,0.947,1,1,135,0.513307984790874,"loop",-1.86666666666667,3.61,0.0002874802357337,4.85191417753471,4.85191414039982,4.85118443551178,1.17497090855698,32,-18,0,0,-18,0,0,0,0,0,0,0,0,0,0,0,0,3,0,-3,4,6,0,6,4,0.244843049327354,-0.101291989664083,0.0946488537940982,-0.0562659846547315,0.0955056179775281,0.726315789473684,0.303525641025641,"Stabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",0.59,1.183,"3:1","146/150","E:Y:H:F:Q:N:R:K:S:G:A:T:P:W:D",1.57937329521209,0.114342297004304,1.0002536454007,1.57897279602454,0.581889091311512,40.4562911075298,0.685913110299906,0.137954936368295,0.860262754777729,0.351471331417763,67.0421060419706,0.278382201819561,"lineage4","dr_mutations_pyrazinamide","ASP",0,"ERR751560","ERR751560","lineage4.3.4.2","pe","","pnca_p.tyr64asp","A","S","TYR","YA64","pnca_complex.pdb"
|
|
"Y64D","L4","PZA","Y","Y64",64,"D",1,"XDR","DM","hydrophobic","hydrophilic","neutral","acidic","polar","neg",8.434,0.546,-0.392,2.59866,-0.33,0.17,69,80,0.947,1,1,135,0.513307984790874,"loop",-1.86666666666667,3.61,0.0002874802357337,4.85191417753471,4.85191414039982,4.85118443551178,1.17497090855698,32,-18,0,0,-18,0,0,0,0,0,0,0,0,0,0,0,0,3,0,-3,4,6,0,6,4,0.244843049327354,-0.101291989664083,0.0946488537940982,-0.0562659846547315,0.0955056179775281,0.726315789473684,0.303525641025641,"Stabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",0.59,1.183,"3:1","146/150","E:Y:H:F:Q:N:R:K:S:G:A:T:P:W:D",1.57937329521209,0.114342297004304,1.0002536454007,1.57897279602454,0.581889091311512,40.4562911075298,0.685913110299906,0.137954936368295,0.860262754777729,0.351471331417763,67.0421060419706,0.278382201819561,"lineage4","dr_mutations_pyrazinamide","ASP",0,"ERR1034784","ERR1034784","lineage4.3.4.2","pe","Peru","pnca_p.tyr64asp","A","S","TYR","YA64","pnca_complex.pdb"
|
|
"Y64D","L2","PZA","Y","Y64",64,"D",0,"XDR","DM","hydrophobic","hydrophilic","neutral","acidic","polar","neg",8.434,0.546,-0.392,2.59866,-0.33,0.17,69,80,0.947,1,1,135,0.513307984790874,"loop",-1.86666666666667,3.61,0.0002874802357337,4.85191417753471,4.85191414039982,4.85118443551178,1.17497090855698,32,-18,0,0,-18,0,0,0,0,0,0,0,0,0,0,0,0,3,0,-3,4,6,0,6,4,0.244843049327354,-0.101291989664083,0.0946488537940982,-0.0562659846547315,0.0955056179775281,0.726315789473684,0.303525641025641,"Stabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",0.59,1.183,"3:1","146/150","E:Y:H:F:Q:N:R:K:S:G:A:T:P:W:D",1.57937329521209,0.114342297004304,1.0002536454007,1.57897279602454,0.581889091311512,40.4562911075298,0.685913110299906,0.137954936368295,0.860262754777729,0.351471331417763,67.0421060419706,0.278382201819561,"lineage2","dr_mutations_pyrazinamide","ASP",0,"SAMN03647400,SRR2100227","SRR2100227","lineage2.2.1","","","pnca_p.tyr64asp","A","S","TYR","YA64","pnca_complex.pdb"
|
|
"S65P","L2","PZA","S","S65",65,"P",0,"Pre-XDR","OM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",8.268,-0.499,-0.032,3.33753,-0.186,-0.19,21,63,-0.697,8,8,97,0.625806451612903,"loop",-0.966666666666667,3.79,0.0001437401178668,1.2119588062211,4.59700131334264e-05,0,1.01056822389159e-25,0,0,0,0,0,0,0,0,0,4,0,4,0,0,0,0,0,0,4,-4,-2,0,0,-2,-2,-0.126393110435664,-0.0082687338501291,0.121560107518266,-0.0317135549872123,-0.0497382198952879,0.221052631578947,-0.574135090609555,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.827,-0.615,"8:7","147/150","L:V:R:K:I:E:Q:D:G:S:A:T",-9.98752126245058,0.942832958100734,139.277183325397,-0.0717096729269463,NA,144471.706314841,0.0834878586628579,1,0,0,25.8386585962163,0.999999999999746,"lineage2","other_mutations_pyrazinamide","PRO",0,"ERR552937,ERS458416,SAMEA2535014","ERR552937","lineage2.2.1","uz","Nukus","pnca_p.ser65pro","A","S","SER","SA65","pnca_complex.pdb"
|
|
"S65P","L2","PZA","S","S65",65,"P",0,"MDR","OM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",8.268,-0.499,-0.032,3.33753,-0.186,-0.19,21,63,-0.697,8,8,97,0.625806451612903,"loop",-0.966666666666667,3.79,0.0001437401178668,1.2119588062211,4.59700131334264e-05,0,1.01056822389159e-25,0,0,0,0,0,0,0,0,0,4,0,4,0,0,0,0,0,0,4,-4,-2,0,0,-2,-2,-0.126393110435664,-0.0082687338501291,0.121560107518266,-0.0317135549872123,-0.0497382198952879,0.221052631578947,-0.574135090609555,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.827,-0.615,"8:7","147/150","L:V:R:K:I:E:Q:D:G:S:A:T",-9.98752126245058,0.942832958100734,139.277183325397,-0.0717096729269463,NA,144471.706314841,0.0834878586628579,1,0,0,25.8386585962163,0.999999999999746,"lineage2","other_mutations_pyrazinamide","PRO",0,"1854R-sc-2012-02-21T11:37:44Z-1364810,ERR144573","ERR144573","lineage2.2.1","ru","Russia,Samara","pnca_p.ser65pro","A","S","SER","SA65","pnca_complex.pdb"
|
|
"S66L","L1","PZA","S","S66",66,"L",0,"Sensitive","OM","hydrophilic","hydrophobic","neutral","non-polar","polar","non-polar",9.005,-0.663,0.201,1.22464,0.084,-0.57,32,66,-0.098,5,5,71,0.458064516129032,"loop",-0.8,3.87,0.0005030904125341,0.346123821533658,1.69039306948873e-05,0,0.489658927611485,-10,0,0,0,0,0,0,0,0,2,0,0,4,0,0,0,0,-1,0,0,-5,0,0,0,0,-0.167933130699088,0.170918367346939,0.0446040545167141,0.070945945945946,-0.149214659685864,0.336842105263158,-0.0807248764415157,"Destabilising","Stabilising","Destabilising","Stabilising","Destabilising","effect",-0.332,-0.038,"6:5","147/150","N:V:I:R:H:F:E:Q:D:T:G:M:S:A",-10.9879643775828,0.928667766494711,122.741582014466,-0.0895211239520097,NA,1.02643587095793,-0.460768509909571,0.611380301705926,0.213688558083325,0,3.36442927964707,0.484079488471969,"lineage1","other_mutations_pyrazinamide","LEU",0,"ERR2514260","ERR2514260","lineage1.1.2","gb","UK","pnca_p.ser66leu","A","S","SER","SA66","pnca_complex.pdb"
|
|
"S66L","L1","PZA","S","S66",66,"L",0,"Sensitive","OM","hydrophilic","hydrophobic","neutral","non-polar","polar","non-polar",9.005,-0.663,0.201,1.22464,0.084,-0.57,32,66,-0.098,5,5,71,0.458064516129032,"loop",-0.8,3.87,0.0005030904125341,0.346123821533658,1.69039306948873e-05,0,0.489658927611485,-10,0,0,0,0,0,0,0,0,2,0,0,4,0,0,0,0,-1,0,0,-5,0,0,0,0,-0.167933130699088,0.170918367346939,0.0446040545167141,0.070945945945946,-0.149214659685864,0.336842105263158,-0.0807248764415157,"Destabilising","Stabilising","Destabilising","Stabilising","Destabilising","effect",-0.332,-0.038,"6:5","147/150","N:V:I:R:H:F:E:Q:D:T:G:M:S:A",-10.9879643775828,0.928667766494711,122.741582014466,-0.0895211239520097,NA,1.02643587095793,-0.460768509909571,0.611380301705926,0.213688558083325,0,3.36442927964707,0.484079488471969,"lineage1","other_mutations_pyrazinamide","LEU",0,"ERR2513978","ERR2513978","lineage1.1.2","gb","UK","pnca_p.ser66leu","A","S","SER","SA66","pnca_complex.pdb"
|
|
"S66L","L1","PZA","S","S66",66,"L",0,"Sensitive","OM","hydrophilic","hydrophobic","neutral","non-polar","polar","non-polar",9.005,-0.663,0.201,1.22464,0.084,-0.57,32,66,-0.098,5,5,71,0.458064516129032,"loop",-0.8,3.87,0.0005030904125341,0.346123821533658,1.69039306948873e-05,0,0.489658927611485,-10,0,0,0,0,0,0,0,0,2,0,0,4,0,0,0,0,-1,0,0,-5,0,0,0,0,-0.167933130699088,0.170918367346939,0.0446040545167141,0.070945945945946,-0.149214659685864,0.336842105263158,-0.0807248764415157,"Destabilising","Stabilising","Destabilising","Stabilising","Destabilising","effect",-0.332,-0.038,"6:5","147/150","N:V:I:R:H:F:E:Q:D:T:G:M:S:A",-10.9879643775828,0.928667766494711,122.741582014466,-0.0895211239520097,NA,1.02643587095793,-0.460768509909571,0.611380301705926,0.213688558083325,0,3.36442927964707,0.484079488471969,"lineage1","other_mutations_pyrazinamide","LEU",0,"ERR2514805","ERR2514805","lineage1.1.2","gb","UK","pnca_p.ser66leu","A","S","SER","SA66","pnca_complex.pdb"
|
|
"S66L","L1","PZA","S","S66",66,"L",0,"Sensitive","OM","hydrophilic","hydrophobic","neutral","non-polar","polar","non-polar",9.005,-0.663,0.201,1.22464,0.084,-0.57,32,66,-0.098,5,5,71,0.458064516129032,"loop",-0.8,3.87,0.0005030904125341,0.346123821533658,1.69039306948873e-05,0,0.489658927611485,-10,0,0,0,0,0,0,0,0,2,0,0,4,0,0,0,0,-1,0,0,-5,0,0,0,0,-0.167933130699088,0.170918367346939,0.0446040545167141,0.070945945945946,-0.149214659685864,0.336842105263158,-0.0807248764415157,"Destabilising","Stabilising","Destabilising","Stabilising","Destabilising","effect",-0.332,-0.038,"6:5","147/150","N:V:I:R:H:F:E:Q:D:T:G:M:S:A",-10.9879643775828,0.928667766494711,122.741582014466,-0.0895211239520097,NA,1.02643587095793,-0.460768509909571,0.611380301705926,0.213688558083325,0,3.36442927964707,0.484079488471969,"lineage1","other_mutations_pyrazinamide","LEU",0,"SRR2100636,SAMN03647809","SRR2100636","lineage1.1.2","","","pnca_p.ser66leu","A","S","SER","SA66","pnca_complex.pdb"
|
|
"S66L","L1","PZA","S","S66",66,"L",0,"Sensitive","OM","hydrophilic","hydrophobic","neutral","non-polar","polar","non-polar",9.005,-0.663,0.201,1.22464,0.084,-0.57,32,66,-0.098,5,5,71,0.458064516129032,"loop",-0.8,3.87,0.0005030904125341,0.346123821533658,1.69039306948873e-05,0,0.489658927611485,-10,0,0,0,0,0,0,0,0,2,0,0,4,0,0,0,0,-1,0,0,-5,0,0,0,0,-0.167933130699088,0.170918367346939,0.0446040545167141,0.070945945945946,-0.149214659685864,0.336842105263158,-0.0807248764415157,"Destabilising","Stabilising","Destabilising","Stabilising","Destabilising","effect",-0.332,-0.038,"6:5","147/150","N:V:I:R:H:F:E:Q:D:T:G:M:S:A",-10.9879643775828,0.928667766494711,122.741582014466,-0.0895211239520097,NA,1.02643587095793,-0.460768509909571,0.611380301705926,0.213688558083325,0,3.36442927964707,0.484079488471969,"lineage1","other_mutations_pyrazinamide","LEU",0,"SAMN03647674,SRR2100501","SRR2100501","lineage1.1.2","","","pnca_p.ser66leu","A","S","SER","SA66","pnca_complex.pdb"
|
|
"S66L","L1","PZA","S","S66",66,"L",0,"Sensitive","OM","hydrophilic","hydrophobic","neutral","non-polar","polar","non-polar",9.005,-0.663,0.201,1.22464,0.084,-0.57,32,66,-0.098,5,5,71,0.458064516129032,"loop",-0.8,3.87,0.0005030904125341,0.346123821533658,1.69039306948873e-05,0,0.489658927611485,-10,0,0,0,0,0,0,0,0,2,0,0,4,0,0,0,0,-1,0,0,-5,0,0,0,0,-0.167933130699088,0.170918367346939,0.0446040545167141,0.070945945945946,-0.149214659685864,0.336842105263158,-0.0807248764415157,"Destabilising","Stabilising","Destabilising","Stabilising","Destabilising","effect",-0.332,-0.038,"6:5","147/150","N:V:I:R:H:F:E:Q:D:T:G:M:S:A",-10.9879643775828,0.928667766494711,122.741582014466,-0.0895211239520097,NA,1.02643587095793,-0.460768509909571,0.611380301705926,0.213688558083325,0,3.36442927964707,0.484079488471969,"lineage1","other_mutations_pyrazinamide","LEU",0,"ERR2514990","ERR2514990","lineage1.1.2","gb","UK","pnca_p.ser66leu","A","S","SER","SA66","pnca_complex.pdb"
|
|
"S66L","L1","PZA","S","S66",66,"L",0,"Sensitive","OM","hydrophilic","hydrophobic","neutral","non-polar","polar","non-polar",9.005,-0.663,0.201,1.22464,0.084,-0.57,32,66,-0.098,5,5,71,0.458064516129032,"loop",-0.8,3.87,0.0005030904125341,0.346123821533658,1.69039306948873e-05,0,0.489658927611485,-10,0,0,0,0,0,0,0,0,2,0,0,4,0,0,0,0,-1,0,0,-5,0,0,0,0,-0.167933130699088,0.170918367346939,0.0446040545167141,0.070945945945946,-0.149214659685864,0.336842105263158,-0.0807248764415157,"Destabilising","Stabilising","Destabilising","Stabilising","Destabilising","effect",-0.332,-0.038,"6:5","147/150","N:V:I:R:H:F:E:Q:D:T:G:M:S:A",-10.9879643775828,0.928667766494711,122.741582014466,-0.0895211239520097,NA,1.02643587095793,-0.460768509909571,0.611380301705926,0.213688558083325,0,3.36442927964707,0.484079488471969,"lineage1","other_mutations_pyrazinamide","LEU",0,"ERR2513739","ERR2513739","lineage1.1.2","gb","UK","pnca_p.ser66leu","A","S","SER","SA66","pnca_complex.pdb"
|
|
"S66P","L4","PZA","S","S66",66,"P",NA,"Pre-MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",9.005,-0.726,-0.248,1.91796,-0.165,-0.07,46,71,-0.098,5,5,71,0.458064516129032,"loop",-0.8,3.87,7.18700589334483e-05,9.70142977291842,188179.926264563,Inf,0.763784339928386,0,0,0,0,0,0,0,0,0,4,0,2,4,0,0,0,0,2,4,-2,-4,0,0,-2,0,-0.183890577507599,-0.0640826873385013,0.0698562780906038,-0.0281329923273657,-0.0183246073298429,0.484210526315789,-0.0807248764415157,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","147/150","N:V:I:R:H:F:E:Q:D:T:G:M:S:A",12.1451538387261,0.919026337424221,119.468044436209,0.101660271548273,5.01153666064915e-06,NA,0.986835744238421,0.170978870202674,0.767057556984365,0.124324963210678,Inf,0.382146811758261,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR1213862","ERR1213862","lineage4","kr","South Korea","pnca_p.ser66pro","A","S","SER","SA66","pnca_complex.pdb"
|
|
"S66P","L4","PZA","S","S66",66,"P",NA,"XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",9.005,-0.726,-0.248,1.91796,-0.165,-0.07,46,71,-0.098,5,5,71,0.458064516129032,"loop",-0.8,3.87,7.18700589334483e-05,9.70142977291842,188179.926264563,Inf,0.763784339928386,0,0,0,0,0,0,0,0,0,4,0,2,4,0,0,0,0,2,4,-2,-4,0,0,-2,0,-0.183890577507599,-0.0640826873385013,0.0698562780906038,-0.0281329923273657,-0.0183246073298429,0.484210526315789,-0.0807248764415157,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","147/150","N:V:I:R:H:F:E:Q:D:T:G:M:S:A",12.1451538387261,0.919026337424221,119.468044436209,0.101660271548273,5.01153666064915e-06,NA,0.986835744238421,0.170978870202674,0.767057556984365,0.124324963210678,Inf,0.382146811758261,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR1193842","ERR1193842","lineage4.3","iq","Iraq","pnca_p.ser66pro","A","S","SER","SA66","pnca_complex.pdb"
|
|
"S66P","L2","PZA","S","S66",66,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",9.005,-0.726,-0.248,1.91796,-0.165,-0.07,46,71,-0.098,5,5,71,0.458064516129032,"loop",-0.8,3.87,7.18700589334483e-05,9.70142977291842,188179.926264563,Inf,0.763784339928386,0,0,0,0,0,0,0,0,0,4,0,2,4,0,0,0,0,2,4,-2,-4,0,0,-2,0,-0.183890577507599,-0.0640826873385013,0.0698562780906038,-0.0281329923273657,-0.0183246073298429,0.484210526315789,-0.0807248764415157,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","147/150","N:V:I:R:H:F:E:Q:D:T:G:M:S:A",12.1451538387261,0.919026337424221,119.468044436209,0.101660271548273,5.01153666064915e-06,NA,0.986835744238421,0.170978870202674,0.767057556984365,0.124324963210678,Inf,0.382146811758261,"lineage2","dr_mutations_pyrazinamide","PRO",0,"ERR2516675","ERR2516675","lineage2.2.1","pe","Peru","pnca_p.ser66pro","A","S","SER","SA66","pnca_complex.pdb"
|
|
"S67L","L4","PZA","S","S67",67,"L",NA,"XDR","OM","hydrophilic","hydrophobic","neutral","non-polar","polar","non-polar",8.658,-1.544,0.61,0.0243891,-0.207,0.22,33,66,-0.355,6,6,15,0.0967741935483871,"loop",-0.833333333333333,5.15,NA,NA,NA,NA,NA,-8,0,0,0,0,0,0,0,0,2,0,0,4,0,0,0,0,-5,0,-2,-5,0,0,0,-2,-0.391084093211753,0.518707482993197,0.000888304110606866,-0.0352941176470588,0.123595505617977,0.347368421052632,-0.292421746293245,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-0.553,-0.244,"7:6","148/150","N:L:V:I:F:Q:W:T:A:M:S:P",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage4","other_mutations_pyrazinamide","LEU",0,"ERR779901","ERR779901","lineage4.3.4.2","pe","","pnca_p.ser67leu","A","-","SER","SA67","pnca_complex.pdb"
|
|
"S67L","L4","PZA","S","S67",67,"L",NA,"XDR","OM","hydrophilic","hydrophobic","neutral","non-polar","polar","non-polar",8.658,-1.544,0.61,0.0243891,-0.207,0.22,33,66,-0.355,6,6,15,0.0967741935483871,"loop",-0.833333333333333,5.15,NA,NA,NA,NA,NA,-8,0,0,0,0,0,0,0,0,2,0,0,4,0,0,0,0,-5,0,-2,-5,0,0,0,-2,-0.391084093211753,0.518707482993197,0.000888304110606866,-0.0352941176470588,0.123595505617977,0.347368421052632,-0.292421746293245,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-0.553,-0.244,"7:6","148/150","N:L:V:I:F:Q:W:T:A:M:S:P",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage4","other_mutations_pyrazinamide","LEU",0,"ERR751548","ERR751548","lineage4.3.3","pe","","pnca_p.ser67leu","A","-","SER","SA67","pnca_complex.pdb"
|
|
"S67L","L4","PZA","S","S67",67,"L",NA,"Pre-XDR","OM","hydrophilic","hydrophobic","neutral","non-polar","polar","non-polar",8.658,-1.544,0.61,0.0243891,-0.207,0.22,33,66,-0.355,6,6,15,0.0967741935483871,"loop",-0.833333333333333,5.15,NA,NA,NA,NA,NA,-8,0,0,0,0,0,0,0,0,2,0,0,4,0,0,0,0,-5,0,-2,-5,0,0,0,-2,-0.391084093211753,0.518707482993197,0.000888304110606866,-0.0352941176470588,0.123595505617977,0.347368421052632,-0.292421746293245,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-0.553,-0.244,"7:6","148/150","N:L:V:I:F:Q:W:T:A:M:S:P",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage4","other_mutations_pyrazinamide","LEU",0,"NG64","ERR1679633","lineage4.6.2.2","ng","Nigeria","pnca_p.ser67leu","A","-","SER","SA67","pnca_complex.pdb"
|
|
"S67P","L2","PZA","S","S67",67,"P",1,"MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",8.658,-1.699,-0.228,3.29311,-0.86,0,40,71,-0.355,6,6,15,0.0967741935483871,"loop",-0.833333333333333,5.15,0.0009343107661348,58.4740177439797,58.4739415306308,58.4547574725378,46.7514830195167,0,0,0,0,0,0,0,0,0,2,0,2,4,0,0,0,0,-2,2,-2,-4,0,0,0,-4,-0.430344478216819,-0.0589147286821705,0.119942234427698,-0.146632566069906,0,0.421052631578947,-0.292421746293245,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.553,-0.244,"7:6","148/150","N:L:V:I:F:Q:W:T:A:M:S:P",4.06858121107736,9.19336449861209e-05,1.04030498364652,3.91095041842055,11.5166635599536,1065.61332397634,1.76696293519342,6.68324361543955e-09,8.17501270782547,8.64086529870195,2465.74647273772,8.05839318437163e-12,"lineage2","dr_mutations_pyrazinamide","PRO",0,"ERR2517333","ERR2517333","lineage2.2.1","nl","Netherlands","pnca_p.ser67pro","A","-","SER","SA67","pnca_complex.pdb"
|
|
"S67P","L2","PZA","S","S67",67,"P",NA,"MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",8.658,-1.699,-0.228,3.29311,-0.86,0,40,71,-0.355,6,6,15,0.0967741935483871,"loop",-0.833333333333333,5.15,0.0009343107661348,58.4740177439797,58.4739415306308,58.4547574725378,46.7514830195167,0,0,0,0,0,0,0,0,0,2,0,2,4,0,0,0,0,-2,2,-2,-4,0,0,0,-4,-0.430344478216819,-0.0589147286821705,0.119942234427698,-0.146632566069906,0,0.421052631578947,-0.292421746293245,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.553,-0.244,"7:6","148/150","N:L:V:I:F:Q:W:T:A:M:S:P",4.06858121107736,9.19336449861209e-05,1.04030498364652,3.91095041842055,11.5166635599536,1065.61332397634,1.76696293519342,6.68324361543955e-09,8.17501270782547,8.64086529870195,2465.74647273772,8.05839318437163e-12,"lineage2","dr_mutations_pyrazinamide","PRO",0,"SRR5065261","SRR5065261","lineage2.2.1","vn","Vietnam","pnca_p.ser67pro","A","-","SER","SA67","pnca_complex.pdb"
|
|
"S67P","L2","PZA","S","S67",67,"P",NA,"Pre-MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",8.658,-1.699,-0.228,3.29311,-0.86,0,40,71,-0.355,6,6,15,0.0967741935483871,"loop",-0.833333333333333,5.15,0.0009343107661348,58.4740177439797,58.4739415306308,58.4547574725378,46.7514830195167,0,0,0,0,0,0,0,0,0,2,0,2,4,0,0,0,0,-2,2,-2,-4,0,0,0,-4,-0.430344478216819,-0.0589147286821705,0.119942234427698,-0.146632566069906,0,0.421052631578947,-0.292421746293245,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.553,-0.244,"7:6","148/150","N:L:V:I:F:Q:W:T:A:M:S:P",4.06858121107736,9.19336449861209e-05,1.04030498364652,3.91095041842055,11.5166635599536,1065.61332397634,1.76696293519342,6.68324361543955e-09,8.17501270782547,8.64086529870195,2465.74647273772,8.05839318437163e-12,"lineage2","dr_mutations_pyrazinamide","PRO",0,"SAMN02398714","SRR1144766_SRR1048009","lineage2.2.1","kr","South Korea","pnca_p.ser67pro","A","-","SER","SA67","pnca_complex.pdb"
|
|
"S67P","L2","PZA","S","S67",67,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",8.658,-1.699,-0.228,3.29311,-0.86,0,40,71,-0.355,6,6,15,0.0967741935483871,"loop",-0.833333333333333,5.15,0.0009343107661348,58.4740177439797,58.4739415306308,58.4547574725378,46.7514830195167,0,0,0,0,0,0,0,0,0,2,0,2,4,0,0,0,0,-2,2,-2,-4,0,0,0,-4,-0.430344478216819,-0.0589147286821705,0.119942234427698,-0.146632566069906,0,0.421052631578947,-0.292421746293245,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.553,-0.244,"7:6","148/150","N:L:V:I:F:Q:W:T:A:M:S:P",4.06858121107736,9.19336449861209e-05,1.04030498364652,3.91095041842055,11.5166635599536,1065.61332397634,1.76696293519342,6.68324361543955e-09,8.17501270782547,8.64086529870195,2465.74647273772,8.05839318437163e-12,"lineage2","dr_mutations_pyrazinamide","PRO",0,"1532R-sc-2012-10-11T13:37:54Z-1494170,ERR228006","ERR228006","lineage2.2.1","ru","Russia,Samara","pnca_p.ser67pro","A","-","SER","SA67","pnca_complex.pdb"
|
|
"S67P","L4","PZA","S","S67",67,"P",1,"Pre-MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",8.658,-1.699,-0.228,3.29311,-0.86,0,40,71,-0.355,6,6,15,0.0967741935483871,"loop",-0.833333333333333,5.15,0.0009343107661348,58.4740177439797,58.4739415306308,58.4547574725378,46.7514830195167,0,0,0,0,0,0,0,0,0,2,0,2,4,0,0,0,0,-2,2,-2,-4,0,0,0,-4,-0.430344478216819,-0.0589147286821705,0.119942234427698,-0.146632566069906,0,0.421052631578947,-0.292421746293245,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.553,-0.244,"7:6","148/150","N:L:V:I:F:Q:W:T:A:M:S:P",4.06858121107736,9.19336449861209e-05,1.04030498364652,3.91095041842055,11.5166635599536,1065.61332397634,1.76696293519342,6.68324361543955e-09,8.17501270782547,8.64086529870195,2465.74647273772,8.05839318437163e-12,"lineage4","dr_mutations_pyrazinamide","PRO",0,"3483","ERR3014585","lineage4.3.1","tn","Tunisia:Tunis","pnca_p.ser67pro","A","-","SER","SA67","pnca_complex.pdb"
|
|
"S67P","L2","PZA","S","S67",67,"P",1,"MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",8.658,-1.699,-0.228,3.29311,-0.86,0,40,71,-0.355,6,6,15,0.0967741935483871,"loop",-0.833333333333333,5.15,0.0009343107661348,58.4740177439797,58.4739415306308,58.4547574725378,46.7514830195167,0,0,0,0,0,0,0,0,0,2,0,2,4,0,0,0,0,-2,2,-2,-4,0,0,0,-4,-0.430344478216819,-0.0589147286821705,0.119942234427698,-0.146632566069906,0,0.421052631578947,-0.292421746293245,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.553,-0.244,"7:6","148/150","N:L:V:I:F:Q:W:T:A:M:S:P",4.06858121107736,9.19336449861209e-05,1.04030498364652,3.91095041842055,11.5166635599536,1065.61332397634,1.76696293519342,6.68324361543955e-09,8.17501270782547,8.64086529870195,2465.74647273772,8.05839318437163e-12,"lineage2","dr_mutations_pyrazinamide","PRO",0,"ERR2516513","ERR2516513","lineage2.2.1","pe","Peru","pnca_p.ser67pro","A","-","SER","SA67","pnca_complex.pdb"
|
|
"S67P","L2","PZA","S","S67",67,"P",NA,"MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",8.658,-1.699,-0.228,3.29311,-0.86,0,40,71,-0.355,6,6,15,0.0967741935483871,"loop",-0.833333333333333,5.15,0.0009343107661348,58.4740177439797,58.4739415306308,58.4547574725378,46.7514830195167,0,0,0,0,0,0,0,0,0,2,0,2,4,0,0,0,0,-2,2,-2,-4,0,0,0,-4,-0.430344478216819,-0.0589147286821705,0.119942234427698,-0.146632566069906,0,0.421052631578947,-0.292421746293245,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.553,-0.244,"7:6","148/150","N:L:V:I:F:Q:W:T:A:M:S:P",4.06858121107736,9.19336449861209e-05,1.04030498364652,3.91095041842055,11.5166635599536,1065.61332397634,1.76696293519342,6.68324361543955e-09,8.17501270782547,8.64086529870195,2465.74647273772,8.05839318437163e-12,"lineage2","dr_mutations_pyrazinamide","PRO",0,"ERR133916","ERR133916","lineage2.2.1","ru","Russia","pnca_p.ser67pro","A","-","SER","SA67","pnca_complex.pdb"
|
|
"S67P","L2","PZA","S","S67",67,"P",NA,"Pre-MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",8.658,-1.699,-0.228,3.29311,-0.86,0,40,71,-0.355,6,6,15,0.0967741935483871,"loop",-0.833333333333333,5.15,0.0009343107661348,58.4740177439797,58.4739415306308,58.4547574725378,46.7514830195167,0,0,0,0,0,0,0,0,0,2,0,2,4,0,0,0,0,-2,2,-2,-4,0,0,0,-4,-0.430344478216819,-0.0589147286821705,0.119942234427698,-0.146632566069906,0,0.421052631578947,-0.292421746293245,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.553,-0.244,"7:6","148/150","N:L:V:I:F:Q:W:T:A:M:S:P",4.06858121107736,9.19336449861209e-05,1.04030498364652,3.91095041842055,11.5166635599536,1065.61332397634,1.76696293519342,6.68324361543955e-09,8.17501270782547,8.64086529870195,2465.74647273772,8.05839318437163e-12,"lineage2","dr_mutations_pyrazinamide","PRO",0,"SRR5065410","SRR5065410","lineage2.2.1","vn","Vietnam","pnca_p.ser67pro","A","-","SER","SA67","pnca_complex.pdb"
|
|
"S67P","L2","PZA","S","S67",67,"P",NA,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",8.658,-1.699,-0.228,3.29311,-0.86,0,40,71,-0.355,6,6,15,0.0967741935483871,"loop",-0.833333333333333,5.15,0.0009343107661348,58.4740177439797,58.4739415306308,58.4547574725378,46.7514830195167,0,0,0,0,0,0,0,0,0,2,0,2,4,0,0,0,0,-2,2,-2,-4,0,0,0,-4,-0.430344478216819,-0.0589147286821705,0.119942234427698,-0.146632566069906,0,0.421052631578947,-0.292421746293245,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.553,-0.244,"7:6","148/150","N:L:V:I:F:Q:W:T:A:M:S:P",4.06858121107736,9.19336449861209e-05,1.04030498364652,3.91095041842055,11.5166635599536,1065.61332397634,1.76696293519342,6.68324361543955e-09,8.17501270782547,8.64086529870195,2465.74647273772,8.05839318437163e-12,"lineage2","dr_mutations_pyrazinamide","PRO",0,"SRR5709761,SAMN07236275","SRR5709761","lineage2.2.1","th","Thailand","pnca_p.ser67pro","A","-","SER","SA67","pnca_complex.pdb"
|
|
"S67P","L3","PZA","S","S67",67,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",8.658,-1.699,-0.228,3.29311,-0.86,0,40,71,-0.355,6,6,15,0.0967741935483871,"loop",-0.833333333333333,5.15,0.0009343107661348,58.4740177439797,58.4739415306308,58.4547574725378,46.7514830195167,0,0,0,0,0,0,0,0,0,2,0,2,4,0,0,0,0,-2,2,-2,-4,0,0,0,-4,-0.430344478216819,-0.0589147286821705,0.119942234427698,-0.146632566069906,0,0.421052631578947,-0.292421746293245,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.553,-0.244,"7:6","148/150","N:L:V:I:F:Q:W:T:A:M:S:P",4.06858121107736,9.19336449861209e-05,1.04030498364652,3.91095041842055,11.5166635599536,1065.61332397634,1.76696293519342,6.68324361543955e-09,8.17501270782547,8.64086529870195,2465.74647273772,8.05839318437163e-12,"lineage3","dr_mutations_pyrazinamide","PRO",0,"ERR2510461","ERR2510461","lineage3","pk","Pakistan","pnca_p.ser67pro","A","-","SER","SA67","pnca_complex.pdb"
|
|
"S67P","L2","PZA","S","S67",67,"P",1,"MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",8.658,-1.699,-0.228,3.29311,-0.86,0,40,71,-0.355,6,6,15,0.0967741935483871,"loop",-0.833333333333333,5.15,0.0009343107661348,58.4740177439797,58.4739415306308,58.4547574725378,46.7514830195167,0,0,0,0,0,0,0,0,0,2,0,2,4,0,0,0,0,-2,2,-2,-4,0,0,0,-4,-0.430344478216819,-0.0589147286821705,0.119942234427698,-0.146632566069906,0,0.421052631578947,-0.292421746293245,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.553,-0.244,"7:6","148/150","N:L:V:I:F:Q:W:T:A:M:S:P",4.06858121107736,9.19336449861209e-05,1.04030498364652,3.91095041842055,11.5166635599536,1065.61332397634,1.76696293519342,6.68324361543955e-09,8.17501270782547,8.64086529870195,2465.74647273772,8.05839318437163e-12,"lineage2","dr_mutations_pyrazinamide","PRO",0,"SAMN10961412","SRR8651622","lineage2.2.1","cn","China:Wenzhou","pnca_p.ser67pro","A","-","SER","SA67","pnca_complex.pdb"
|
|
"S67P","L2","PZA","S","S67",67,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",8.658,-1.699,-0.228,3.29311,-0.86,0,40,71,-0.355,6,6,15,0.0967741935483871,"loop",-0.833333333333333,5.15,0.0009343107661348,58.4740177439797,58.4739415306308,58.4547574725378,46.7514830195167,0,0,0,0,0,0,0,0,0,2,0,2,4,0,0,0,0,-2,2,-2,-4,0,0,0,-4,-0.430344478216819,-0.0589147286821705,0.119942234427698,-0.146632566069906,0,0.421052631578947,-0.292421746293245,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.553,-0.244,"7:6","148/150","N:L:V:I:F:Q:W:T:A:M:S:P",4.06858121107736,9.19336449861209e-05,1.04030498364652,3.91095041842055,11.5166635599536,1065.61332397634,1.76696293519342,6.68324361543955e-09,8.17501270782547,8.64086529870195,2465.74647273772,8.05839318437163e-12,"lineage2","dr_mutations_pyrazinamide","PRO",0,"ERR2510361","ERR2510361","lineage2.2.1","pk","Pakistan","pnca_p.ser67pro","A","-","SER","SA67","pnca_complex.pdb"
|
|
"S67P","L2","PZA","S","S67",67,"P",NA,"MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",8.658,-1.699,-0.228,3.29311,-0.86,0,40,71,-0.355,6,6,15,0.0967741935483871,"loop",-0.833333333333333,5.15,0.0009343107661348,58.4740177439797,58.4739415306308,58.4547574725378,46.7514830195167,0,0,0,0,0,0,0,0,0,2,0,2,4,0,0,0,0,-2,2,-2,-4,0,0,0,-4,-0.430344478216819,-0.0589147286821705,0.119942234427698,-0.146632566069906,0,0.421052631578947,-0.292421746293245,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.553,-0.244,"7:6","148/150","N:L:V:I:F:Q:W:T:A:M:S:P",4.06858121107736,9.19336449861209e-05,1.04030498364652,3.91095041842055,11.5166635599536,1065.61332397634,1.76696293519342,6.68324361543955e-09,8.17501270782547,8.64086529870195,2465.74647273772,8.05839318437163e-12,"lineage2","dr_mutations_pyrazinamide","PRO",0,"SRR5065326","SRR5065326","lineage2.2.1","vn","Vietnam","pnca_p.ser67pro","A","-","SER","SA67","pnca_complex.pdb"
|
|
"S67P","L2","PZA","S","S67",67,"P",NA,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",8.658,-1.699,-0.228,3.29311,-0.86,0,40,71,-0.355,6,6,15,0.0967741935483871,"loop",-0.833333333333333,5.15,0.0009343107661348,58.4740177439797,58.4739415306308,58.4547574725378,46.7514830195167,0,0,0,0,0,0,0,0,0,2,0,2,4,0,0,0,0,-2,2,-2,-4,0,0,0,-4,-0.430344478216819,-0.0589147286821705,0.119942234427698,-0.146632566069906,0,0.421052631578947,-0.292421746293245,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.553,-0.244,"7:6","148/150","N:L:V:I:F:Q:W:T:A:M:S:P",4.06858121107736,9.19336449861209e-05,1.04030498364652,3.91095041842055,11.5166635599536,1065.61332397634,1.76696293519342,6.68324361543955e-09,8.17501270782547,8.64086529870195,2465.74647273772,8.05839318437163e-12,"lineage2","dr_mutations_pyrazinamide","PRO",0,"SRR5709757,SAMN07236271","SRR5709757","lineage2.2.1","th","Thailand","pnca_p.ser67pro","A","-","SER","SA67","pnca_complex.pdb"
|
|
"S67P","L3","PZA","S","S67",67,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",8.658,-1.699,-0.228,3.29311,-0.86,0,40,71,-0.355,6,6,15,0.0967741935483871,"loop",-0.833333333333333,5.15,0.0009343107661348,58.4740177439797,58.4739415306308,58.4547574725378,46.7514830195167,0,0,0,0,0,0,0,0,0,2,0,2,4,0,0,0,0,-2,2,-2,-4,0,0,0,-4,-0.430344478216819,-0.0589147286821705,0.119942234427698,-0.146632566069906,0,0.421052631578947,-0.292421746293245,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.553,-0.244,"7:6","148/150","N:L:V:I:F:Q:W:T:A:M:S:P",4.06858121107736,9.19336449861209e-05,1.04030498364652,3.91095041842055,11.5166635599536,1065.61332397634,1.76696293519342,6.68324361543955e-09,8.17501270782547,8.64086529870195,2465.74647273772,8.05839318437163e-12,"lineage3","dr_mutations_pyrazinamide","PRO",0,"ERR2510389","ERR2510389","lineage3","pk","Pakistan","pnca_p.ser67pro","A","-","SER","SA67","pnca_complex.pdb"
|
|
"S67P","L2","PZA","S","S67",67,"P",1,"MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",8.658,-1.699,-0.228,3.29311,-0.86,0,40,71,-0.355,6,6,15,0.0967741935483871,"loop",-0.833333333333333,5.15,0.0009343107661348,58.4740177439797,58.4739415306308,58.4547574725378,46.7514830195167,0,0,0,0,0,0,0,0,0,2,0,2,4,0,0,0,0,-2,2,-2,-4,0,0,0,-4,-0.430344478216819,-0.0589147286821705,0.119942234427698,-0.146632566069906,0,0.421052631578947,-0.292421746293245,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.553,-0.244,"7:6","148/150","N:L:V:I:F:Q:W:T:A:M:S:P",4.06858121107736,9.19336449861209e-05,1.04030498364652,3.91095041842055,11.5166635599536,1065.61332397634,1.76696293519342,6.68324361543955e-09,8.17501270782547,8.64086529870195,2465.74647273772,8.05839318437163e-12,"lineage2","dr_mutations_pyrazinamide","PRO",0,"ERR2516263","ERR2516263","lineage2.2.1","be","Belgium","pnca_p.ser67pro","A","-","SER","SA67","pnca_complex.pdb"
|
|
"S67P","L2","PZA","S","S67",67,"P",0,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",8.658,-1.699,-0.228,3.29311,-0.86,0,40,71,-0.355,6,6,15,0.0967741935483871,"loop",-0.833333333333333,5.15,0.0009343107661348,58.4740177439797,58.4739415306308,58.4547574725378,46.7514830195167,0,0,0,0,0,0,0,0,0,2,0,2,4,0,0,0,0,-2,2,-2,-4,0,0,0,-4,-0.430344478216819,-0.0589147286821705,0.119942234427698,-0.146632566069906,0,0.421052631578947,-0.292421746293245,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.553,-0.244,"7:6","148/150","N:L:V:I:F:Q:W:T:A:M:S:P",4.06858121107736,9.19336449861209e-05,1.04030498364652,3.91095041842055,11.5166635599536,1065.61332397634,1.76696293519342,6.68324361543955e-09,8.17501270782547,8.64086529870195,2465.74647273772,8.05839318437163e-12,"lineage2","dr_mutations_pyrazinamide","PRO",0,"ERR2516781","ERR2516781","lineage2.2.2","gb","UK","pnca_p.ser67pro","A","-","SER","SA67","pnca_complex.pdb"
|
|
"S67P","L2","PZA","S","S67",67,"P",NA,"Pre-MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",8.658,-1.699,-0.228,3.29311,-0.86,0,40,71,-0.355,6,6,15,0.0967741935483871,"loop",-0.833333333333333,5.15,0.0009343107661348,58.4740177439797,58.4739415306308,58.4547574725378,46.7514830195167,0,0,0,0,0,0,0,0,0,2,0,2,4,0,0,0,0,-2,2,-2,-4,0,0,0,-4,-0.430344478216819,-0.0589147286821705,0.119942234427698,-0.146632566069906,0,0.421052631578947,-0.292421746293245,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.553,-0.244,"7:6","148/150","N:L:V:I:F:Q:W:T:A:M:S:P",4.06858121107736,9.19336449861209e-05,1.04030498364652,3.91095041842055,11.5166635599536,1065.61332397634,1.76696293519342,6.68324361543955e-09,8.17501270782547,8.64086529870195,2465.74647273772,8.05839318437163e-12,"lineage2","dr_mutations_pyrazinamide","PRO",0,"SAMN02360598","SRR1049032_SRR1013638_SRR1049033_SRR1013639","lineage2.2.1","kr","South Korea","pnca_p.ser67pro","A","-","SER","SA67","pnca_complex.pdb"
|
|
"S67P","L2","PZA","S","S67",67,"P",NA,"MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",8.658,-1.699,-0.228,3.29311,-0.86,0,40,71,-0.355,6,6,15,0.0967741935483871,"loop",-0.833333333333333,5.15,0.0009343107661348,58.4740177439797,58.4739415306308,58.4547574725378,46.7514830195167,0,0,0,0,0,0,0,0,0,2,0,2,4,0,0,0,0,-2,2,-2,-4,0,0,0,-4,-0.430344478216819,-0.0589147286821705,0.119942234427698,-0.146632566069906,0,0.421052631578947,-0.292421746293245,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.553,-0.244,"7:6","148/150","N:L:V:I:F:Q:W:T:A:M:S:P",4.06858121107736,9.19336449861209e-05,1.04030498364652,3.91095041842055,11.5166635599536,1065.61332397634,1.76696293519342,6.68324361543955e-09,8.17501270782547,8.64086529870195,2465.74647273772,8.05839318437163e-12,"lineage2","dr_mutations_pyrazinamide","PRO",0,"ERR3275274","ERR3275274","lineage2.2.1","nl","Netherlands","pnca_p.ser67pro","A","-","SER","SA67","pnca_complex.pdb"
|
|
"S67P","L2","PZA","S","S67",67,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",8.658,-1.699,-0.228,3.29311,-0.86,0,40,71,-0.355,6,6,15,0.0967741935483871,"loop",-0.833333333333333,5.15,0.0009343107661348,58.4740177439797,58.4739415306308,58.4547574725378,46.7514830195167,0,0,0,0,0,0,0,0,0,2,0,2,4,0,0,0,0,-2,2,-2,-4,0,0,0,-4,-0.430344478216819,-0.0589147286821705,0.119942234427698,-0.146632566069906,0,0.421052631578947,-0.292421746293245,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.553,-0.244,"7:6","148/150","N:L:V:I:F:Q:W:T:A:M:S:P",4.06858121107736,9.19336449861209e-05,1.04030498364652,3.91095041842055,11.5166635599536,1065.61332397634,1.76696293519342,6.68324361543955e-09,8.17501270782547,8.64086529870195,2465.74647273772,8.05839318437163e-12,"lineage2","dr_mutations_pyrazinamide","PRO",0,"ERR228028,2312P-sc-2012-10-11T13:38:15Z-1494192","ERR228028","lineage2.2.1","ru","Russia,Samara","pnca_p.ser67pro","A","-","SER","SA67","pnca_complex.pdb"
|
|
"S67P","L2","PZA","S","S67",67,"P",NA,"XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",8.658,-1.699,-0.228,3.29311,-0.86,0,40,71,-0.355,6,6,15,0.0967741935483871,"loop",-0.833333333333333,5.15,0.0009343107661348,58.4740177439797,58.4739415306308,58.4547574725378,46.7514830195167,0,0,0,0,0,0,0,0,0,2,0,2,4,0,0,0,0,-2,2,-2,-4,0,0,0,-4,-0.430344478216819,-0.0589147286821705,0.119942234427698,-0.146632566069906,0,0.421052631578947,-0.292421746293245,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.553,-0.244,"7:6","148/150","N:L:V:I:F:Q:W:T:A:M:S:P",4.06858121107736,9.19336449861209e-05,1.04030498364652,3.91095041842055,11.5166635599536,1065.61332397634,1.76696293519342,6.68324361543955e-09,8.17501270782547,8.64086529870195,2465.74647273772,8.05839318437163e-12,"lineage2","dr_mutations_pyrazinamide","PRO",0,"SRR5266544","SRR5266544","lineage2.2.1","ru","Russia","pnca_p.ser67pro","A","-","SER","SA67","pnca_complex.pdb"
|
|
"S67P","L4","PZA","S","S67",67,"P",NA,"MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",8.658,-1.699,-0.228,3.29311,-0.86,0,40,71,-0.355,6,6,15,0.0967741935483871,"loop",-0.833333333333333,5.15,0.0009343107661348,58.4740177439797,58.4739415306308,58.4547574725378,46.7514830195167,0,0,0,0,0,0,0,0,0,2,0,2,4,0,0,0,0,-2,2,-2,-4,0,0,0,-4,-0.430344478216819,-0.0589147286821705,0.119942234427698,-0.146632566069906,0,0.421052631578947,-0.292421746293245,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.553,-0.244,"7:6","148/150","N:L:V:I:F:Q:W:T:A:M:S:P",4.06858121107736,9.19336449861209e-05,1.04030498364652,3.91095041842055,11.5166635599536,1065.61332397634,1.76696293519342,6.68324361543955e-09,8.17501270782547,8.64086529870195,2465.74647273772,8.05839318437163e-12,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR2706913","ERR2706913","lineage4.9","cd","Democratic Republic of Congo","pnca_p.ser67pro","A","-","SER","SA67","pnca_complex.pdb"
|
|
"S67P","L2","PZA","S","S67",67,"P",1,"XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",8.658,-1.699,-0.228,3.29311,-0.86,0,40,71,-0.355,6,6,15,0.0967741935483871,"loop",-0.833333333333333,5.15,0.0009343107661348,58.4740177439797,58.4739415306308,58.4547574725378,46.7514830195167,0,0,0,0,0,0,0,0,0,2,0,2,4,0,0,0,0,-2,2,-2,-4,0,0,0,-4,-0.430344478216819,-0.0589147286821705,0.119942234427698,-0.146632566069906,0,0.421052631578947,-0.292421746293245,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.553,-0.244,"7:6","148/150","N:L:V:I:F:Q:W:T:A:M:S:P",4.06858121107736,9.19336449861209e-05,1.04030498364652,3.91095041842055,11.5166635599536,1065.61332397634,1.76696293519342,6.68324361543955e-09,8.17501270782547,8.64086529870195,2465.74647273772,8.05839318437163e-12,"lineage2","dr_mutations_pyrazinamide","PRO",0,"ERR2510321","ERR2510321","lineage2.2.1","pk","Pakistan","pnca_p.ser67pro","A","-","SER","SA67","pnca_complex.pdb"
|
|
"S67P","L2","PZA","S","S67",67,"P",NA,"MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",8.658,-1.699,-0.228,3.29311,-0.86,0,40,71,-0.355,6,6,15,0.0967741935483871,"loop",-0.833333333333333,5.15,0.0009343107661348,58.4740177439797,58.4739415306308,58.4547574725378,46.7514830195167,0,0,0,0,0,0,0,0,0,2,0,2,4,0,0,0,0,-2,2,-2,-4,0,0,0,-4,-0.430344478216819,-0.0589147286821705,0.119942234427698,-0.146632566069906,0,0.421052631578947,-0.292421746293245,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.553,-0.244,"7:6","148/150","N:L:V:I:F:Q:W:T:A:M:S:P",4.06858121107736,9.19336449861209e-05,1.04030498364652,3.91095041842055,11.5166635599536,1065.61332397634,1.76696293519342,6.68324361543955e-09,8.17501270782547,8.64086529870195,2465.74647273772,8.05839318437163e-12,"lineage2","dr_mutations_pyrazinamide","PRO",0,"ERR2446586","ERR2446586","lineage2.2.1","nl","Netherlands","pnca_p.ser67pro","A","-","SER","SA67","pnca_complex.pdb"
|
|
"S67P","L4","PZA","S","S67",67,"P",1,"MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",8.658,-1.699,-0.228,3.29311,-0.86,0,40,71,-0.355,6,6,15,0.0967741935483871,"loop",-0.833333333333333,5.15,0.0009343107661348,58.4740177439797,58.4739415306308,58.4547574725378,46.7514830195167,0,0,0,0,0,0,0,0,0,2,0,2,4,0,0,0,0,-2,2,-2,-4,0,0,0,-4,-0.430344478216819,-0.0589147286821705,0.119942234427698,-0.146632566069906,0,0.421052631578947,-0.292421746293245,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.553,-0.244,"7:6","148/150","N:L:V:I:F:Q:W:T:A:M:S:P",4.06858121107736,9.19336449861209e-05,1.04030498364652,3.91095041842055,11.5166635599536,1065.61332397634,1.76696293519342,6.68324361543955e-09,8.17501270782547,8.64086529870195,2465.74647273772,8.05839318437163e-12,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR038747","ERR038747","lineage4.8","ug","Uganda","pnca_p.ser67pro","A","-","SER","SA67","pnca_complex.pdb"
|
|
"S67T","L1","PZA","S","S67",67,"T",NA,"Pre-MDR","OM","hydrophilic","hydrophobic","neutral","neutral","polar","polar",8.658,-1.302,-0.129,-0.265321,-0.27,-0.1,-47,72,-0.355,6,6,15,0.0967741935483871,"loop",-0.833333333333333,5.15,NA,NA,NA,NA,NA,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-8,0,-6,-2,0,0,0,-4,-0.329787234042553,-0.0333333333333333,-0.0510114973467661,-0.0460358056265985,-0.0261780104712041,-0.505376344086022,-0.292421746293245,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","neutral",-0.553,-0.244,"7:6","148/150","N:L:V:I:F:Q:W:T:A:M:S:P",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage1","other_mutations_pyrazinamide","THR",0,"ERR702404","ERR702404","lineage1","gh","Ghana","pnca_p.ser67thr","A","-","SER","SA67","pnca_complex.pdb"
|
|
"S67W","L2","PZA","S","S67",67,"W",NA,"Pre-XDR","OM","hydrophilic","hydrophobic","neutral","non-polar","polar","non-polar",8.658,-0.833,-0.832,0.201358,-0.082,-0.65,39,66,-0.355,6,6,15,0.0967741935483871,"loop",-0.833333333333333,5.15,7.18700589334483e-05,9.70142977291842,188179.926264541,Inf,0.763784339928386,-10,-4,0,0,-4,0,0,0,0,0,0,0,2,0,0,0,0,-4,0,-4,-4,0,0,0,-6,-0.210992907801418,-0.214987080103359,0.00733389666300016,-0.0139812446717818,-0.170157068062827,0.410526315789474,-0.292421746293245,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.553,-0.244,"7:6","148/150","N:L:V:I:F:Q:W:T:A:M:S:P",12.145153838726,0.919026337424218,119.468044436204,0.101660271548276,5.01153666065335e-06,NA,0.986835744238421,0.170978870202674,0.767057556984365,0.124324963210678,Inf,0.382146811758261,"lineage2","other_mutations_pyrazinamide","TRP",0,"ERR2515719","ERR2515719","lineage2.2.1","za","South Africa","pnca_p.ser67trp","A","-","SER","SA67","pnca_complex.pdb"
|
|
"S67W","L2","PZA","S","S67",67,"W",NA,"MDR","OM","hydrophilic","hydrophobic","neutral","non-polar","polar","non-polar",8.658,-0.833,-0.832,0.201358,-0.082,-0.65,39,66,-0.355,6,6,15,0.0967741935483871,"loop",-0.833333333333333,5.15,7.18700589334483e-05,9.70142977291842,188179.926264541,Inf,0.763784339928386,-10,-4,0,0,-4,0,0,0,0,0,0,0,2,0,0,0,0,-4,0,-4,-4,0,0,0,-6,-0.210992907801418,-0.214987080103359,0.00733389666300016,-0.0139812446717818,-0.170157068062827,0.410526315789474,-0.292421746293245,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.553,-0.244,"7:6","148/150","N:L:V:I:F:Q:W:T:A:M:S:P",12.145153838726,0.919026337424218,119.468044436204,0.101660271548276,5.01153666065335e-06,NA,0.986835744238421,0.170978870202674,0.767057556984365,0.124324963210678,Inf,0.382146811758261,"lineage2","other_mutations_pyrazinamide","TRP",0,"SRR5709906,SAMN07236408","SRR5709906","lineage2.2.2","th","Thailand","pnca_p.ser67trp","A","-","SER","SA67","pnca_complex.pdb"
|
|
"S67W","L2","PZA","S","S67",67,"W",1,"Pre-XDR","OM","hydrophilic","hydrophobic","neutral","non-polar","polar","non-polar",8.658,-0.833,-0.832,0.201358,-0.082,-0.65,39,66,-0.355,6,6,15,0.0967741935483871,"loop",-0.833333333333333,5.15,7.18700589334483e-05,9.70142977291842,188179.926264541,Inf,0.763784339928386,-10,-4,0,0,-4,0,0,0,0,0,0,0,2,0,0,0,0,-4,0,-4,-4,0,0,0,-6,-0.210992907801418,-0.214987080103359,0.00733389666300016,-0.0139812446717818,-0.170157068062827,0.410526315789474,-0.292421746293245,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.553,-0.244,"7:6","148/150","N:L:V:I:F:Q:W:T:A:M:S:P",12.145153838726,0.919026337424218,119.468044436204,0.101660271548276,5.01153666065335e-06,NA,0.986835744238421,0.170978870202674,0.767057556984365,0.124324963210678,Inf,0.382146811758261,"lineage2","other_mutations_pyrazinamide","TRP",0,"ERR2516624","ERR2516624","lineage2.2.1","pe","Peru","pnca_p.ser67trp","A","-","SER","SA67","pnca_complex.pdb"
|
|
"W68C","L4","PZA","W","W68",68,"C",1,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",4.974,-1.575,-1.453,2.68091,-1.561,-1.46,78,85,-1.146,9,9,45,0.157894736842105,"strand",-1.1,5.49,0.0004312203536006,24.2923336141533,24.2923334241599,24.2833096922897,14.1977442691074,46,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,4,2,0,0,4,-0.398936170212766,-0.375452196382429,0.0976445778305495,-0.26615515771526,-0.382198952879581,0.821052631578947,-0.943986820428336,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.124,"9:9","150/150","F:W",3.19016080361872,0.0035954281300595,1.09565968954934,2.91163472932995,3.91551977432164,465.531063220521,1.38546923679232,0.0007494070007895,3.12528225414311,2.71567844828345,1141.60089496884,0.0001645676755807,"lineage4","dr_mutations_pyrazinamide","CYS",0,"ERS2592795","ERR2677450","lineage4.6","de","Germany","pnca_p.trp68cys","A","B","TRP","WA68","pnca_complex.pdb"
|
|
"W68C","L3","PZA","W","W68",68,"C",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",4.974,-1.575,-1.453,2.68091,-1.561,-1.46,78,85,-1.146,9,9,45,0.157894736842105,"strand",-1.1,5.49,0.0004312203536006,24.2923336141533,24.2923334241599,24.2833096922897,14.1977442691074,46,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,4,2,0,0,4,-0.398936170212766,-0.375452196382429,0.0976445778305495,-0.26615515771526,-0.382198952879581,0.821052631578947,-0.943986820428336,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.124,"9:9","150/150","F:W",3.19016080361872,0.0035954281300595,1.09565968954934,2.91163472932995,3.91551977432164,465.531063220521,1.38546923679232,0.0007494070007895,3.12528225414311,2.71567844828345,1141.60089496884,0.0001645676755807,"lineage3","dr_mutations_pyrazinamide","CYS",0,"SAMN02350435","SRR1062848_SRR1011477","lineage3.1.1","za","South Africa","pnca_p.trp68cys","A","B","TRP","WA68","pnca_complex.pdb"
|
|
"W68C","L3","PZA","W","W68",68,"C",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",4.974,-1.575,-1.453,2.68091,-1.561,-1.46,78,85,-1.146,9,9,45,0.157894736842105,"strand",-1.1,5.49,0.0004312203536006,24.2923336141533,24.2923334241599,24.2833096922897,14.1977442691074,46,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,4,2,0,0,4,-0.398936170212766,-0.375452196382429,0.0976445778305495,-0.26615515771526,-0.382198952879581,0.821052631578947,-0.943986820428336,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.124,"9:9","150/150","F:W",3.19016080361872,0.0035954281300595,1.09565968954934,2.91163472932995,3.91551977432164,465.531063220521,1.38546923679232,0.0007494070007895,3.12528225414311,2.71567844828345,1141.60089496884,0.0001645676755807,"lineage3","dr_mutations_pyrazinamide","CYS",0,"SAMN02403591","SRR1172165_SRR1165655_SRR1167351_SRR1168954","lineage3.1.1","za","South Africa","pnca_p.trp68cys","A","B","TRP","WA68","pnca_complex.pdb"
|
|
"W68C","L3","PZA","W","W68",68,"C",1,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",4.974,-1.575,-1.453,2.68091,-1.561,-1.46,78,85,-1.146,9,9,45,0.157894736842105,"strand",-1.1,5.49,0.0004312203536006,24.2923336141533,24.2923334241599,24.2833096922897,14.1977442691074,46,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,4,2,0,0,4,-0.398936170212766,-0.375452196382429,0.0976445778305495,-0.26615515771526,-0.382198952879581,0.821052631578947,-0.943986820428336,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.124,"9:9","150/150","F:W",3.19016080361872,0.0035954281300595,1.09565968954934,2.91163472932995,3.91551977432164,465.531063220521,1.38546923679232,0.0007494070007895,3.12528225414311,2.71567844828345,1141.60089496884,0.0001645676755807,"lineage3","dr_mutations_pyrazinamide","CYS",0,"ERR2510442","ERR2510442","lineage3","pk","Pakistan","pnca_p.trp68cys","A","B","TRP","WA68","pnca_complex.pdb"
|
|
"W68C","L3","PZA","W","W68",68,"C",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",4.974,-1.575,-1.453,2.68091,-1.561,-1.46,78,85,-1.146,9,9,45,0.157894736842105,"strand",-1.1,5.49,0.0004312203536006,24.2923336141533,24.2923334241599,24.2833096922897,14.1977442691074,46,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,4,2,0,0,4,-0.398936170212766,-0.375452196382429,0.0976445778305495,-0.26615515771526,-0.382198952879581,0.821052631578947,-0.943986820428336,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.124,"9:9","150/150","F:W",3.19016080361872,0.0035954281300595,1.09565968954934,2.91163472932995,3.91551977432164,465.531063220521,1.38546923679232,0.0007494070007895,3.12528225414311,2.71567844828345,1141.60089496884,0.0001645676755807,"lineage3","dr_mutations_pyrazinamide","CYS",0,"SAMN02403531","SRR1165270_SRR1175440_SRR1167290_SRR1173283","lineage3.1.1","za","South Africa","pnca_p.trp68cys","A","B","TRP","WA68","pnca_complex.pdb"
|
|
"W68C","L3","PZA","W","W68",68,"C",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",4.974,-1.575,-1.453,2.68091,-1.561,-1.46,78,85,-1.146,9,9,45,0.157894736842105,"strand",-1.1,5.49,0.0004312203536006,24.2923336141533,24.2923334241599,24.2833096922897,14.1977442691074,46,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,4,2,0,0,4,-0.398936170212766,-0.375452196382429,0.0976445778305495,-0.26615515771526,-0.382198952879581,0.821052631578947,-0.943986820428336,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.124,"9:9","150/150","F:W",3.19016080361872,0.0035954281300595,1.09565968954934,2.91163472932995,3.91551977432164,465.531063220521,1.38546923679232,0.0007494070007895,3.12528225414311,2.71567844828345,1141.60089496884,0.0001645676755807,"lineage3","dr_mutations_pyrazinamide","CYS",0,"SAMN02586091","SRR1172969_SRR1184292_SRR1196563_SRR1175029","lineage3.1.1","za","South Africa","pnca_p.trp68cys","A","B","TRP","WA68","pnca_complex.pdb"
|
|
"W68C","L3","PZA","W","W68",68,"C",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",4.974,-1.575,-1.453,2.68091,-1.561,-1.46,78,85,-1.146,9,9,45,0.157894736842105,"strand",-1.1,5.49,0.0004312203536006,24.2923336141533,24.2923334241599,24.2833096922897,14.1977442691074,46,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,4,2,0,0,4,-0.398936170212766,-0.375452196382429,0.0976445778305495,-0.26615515771526,-0.382198952879581,0.821052631578947,-0.943986820428336,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.124,"9:9","150/150","F:W",3.19016080361872,0.0035954281300595,1.09565968954934,2.91163472932995,3.91551977432164,465.531063220521,1.38546923679232,0.0007494070007895,3.12528225414311,2.71567844828345,1141.60089496884,0.0001645676755807,"lineage3","dr_mutations_pyrazinamide","CYS",0,"SAMN02586046","SRR1175075_SRR1196499_SRR1184357_SRR1172744","lineage3.1.1","za","South Africa","pnca_p.trp68cys","A","B","TRP","WA68","pnca_complex.pdb"
|
|
"W68C","L2","PZA","W","W68",68,"C",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",4.974,-1.575,-1.453,2.68091,-1.561,-1.46,78,85,-1.146,9,9,45,0.157894736842105,"strand",-1.1,5.49,0.0004312203536006,24.2923336141533,24.2923334241599,24.2833096922897,14.1977442691074,46,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,4,2,0,0,4,-0.398936170212766,-0.375452196382429,0.0976445778305495,-0.26615515771526,-0.382198952879581,0.821052631578947,-0.943986820428336,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.124,"9:9","150/150","F:W",3.19016080361872,0.0035954281300595,1.09565968954934,2.91163472932995,3.91551977432164,465.531063220521,1.38546923679232,0.0007494070007895,3.12528225414311,2.71567844828345,1141.60089496884,0.0001645676755807,"lineage2","dr_mutations_pyrazinamide","CYS",0,"SAMN07236354,SRR5709922","SRR5709922","lineage2.2.1.1","th","Thailand","pnca_p.trp68cys","A","B","TRP","WA68","pnca_complex.pdb"
|
|
"W68C","L3","PZA","W","W68",68,"C",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",4.974,-1.575,-1.453,2.68091,-1.561,-1.46,78,85,-1.146,9,9,45,0.157894736842105,"strand",-1.1,5.49,0.0004312203536006,24.2923336141533,24.2923334241599,24.2833096922897,14.1977442691074,46,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,4,2,0,0,4,-0.398936170212766,-0.375452196382429,0.0976445778305495,-0.26615515771526,-0.382198952879581,0.821052631578947,-0.943986820428336,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.124,"9:9","150/150","F:W",3.19016080361872,0.0035954281300595,1.09565968954934,2.91163472932995,3.91551977432164,465.531063220521,1.38546923679232,0.0007494070007895,3.12528225414311,2.71567844828345,1141.60089496884,0.0001645676755807,"lineage3","dr_mutations_pyrazinamide","CYS",0,"SAMN02403539","SRR1167374_SRR1169295_SRR1165657_SRR1169214","lineage3.1.1","za","South Africa","pnca_p.trp68cys","A","B","TRP","WA68","pnca_complex.pdb"
|
|
"W68C","L3","PZA","W","W68",68,"C",0,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",4.974,-1.575,-1.453,2.68091,-1.561,-1.46,78,85,-1.146,9,9,45,0.157894736842105,"strand",-1.1,5.49,0.0004312203536006,24.2923336141533,24.2923334241599,24.2833096922897,14.1977442691074,46,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,4,2,0,0,4,-0.398936170212766,-0.375452196382429,0.0976445778305495,-0.26615515771526,-0.382198952879581,0.821052631578947,-0.943986820428336,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.124,"9:9","150/150","F:W",3.19016080361872,0.0035954281300595,1.09565968954934,2.91163472932995,3.91551977432164,465.531063220521,1.38546923679232,0.0007494070007895,3.12528225414311,2.71567844828345,1141.60089496884,0.0001645676755807,"lineage3","dr_mutations_pyrazinamide","CYS",0,"ERR2510542","ERR2510542","lineage3","pk","Pakistan","pnca_p.trp68cys","A","B","TRP","WA68","pnca_complex.pdb"
|
|
"W68C","L4","PZA","W","W68",68,"C",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",4.974,-1.575,-1.453,2.68091,-1.561,-1.46,78,85,-1.146,9,9,45,0.157894736842105,"strand",-1.1,5.49,0.0004312203536006,24.2923336141533,24.2923334241599,24.2833096922897,14.1977442691074,46,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,4,2,0,0,4,-0.398936170212766,-0.375452196382429,0.0976445778305495,-0.26615515771526,-0.382198952879581,0.821052631578947,-0.943986820428336,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.124,"9:9","150/150","F:W",3.19016080361872,0.0035954281300595,1.09565968954934,2.91163472932995,3.91551977432164,465.531063220521,1.38546923679232,0.0007494070007895,3.12528225414311,2.71567844828345,1141.60089496884,0.0001645676755807,"lineage4","dr_mutations_pyrazinamide","CYS",0,"ERR1035276","ERR1035276","lineage4.3.3","br","Brazil","pnca_p.trp68cys","A","B","TRP","WA68","pnca_complex.pdb"
|
|
"W68C","L3","PZA","W","W68",68,"C",1,"Pre-MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",4.974,-1.575,-1.453,2.68091,-1.561,-1.46,78,85,-1.146,9,9,45,0.157894736842105,"strand",-1.1,5.49,0.0004312203536006,24.2923336141533,24.2923334241599,24.2833096922897,14.1977442691074,46,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,4,2,0,0,4,-0.398936170212766,-0.375452196382429,0.0976445778305495,-0.26615515771526,-0.382198952879581,0.821052631578947,-0.943986820428336,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.124,"9:9","150/150","F:W",3.19016080361872,0.0035954281300595,1.09565968954934,2.91163472932995,3.91551977432164,465.531063220521,1.38546923679232,0.0007494070007895,3.12528225414311,2.71567844828345,1141.60089496884,0.0001645676755807,"lineage3","dr_mutations_pyrazinamide","CYS",0,"SAMN02053756","SRR833181_SRR833020_SRR833193","lineage3.1.1","za","South Africa","pnca_p.trp68cys","A","B","TRP","WA68","pnca_complex.pdb"
|
|
"W68C","L3","PZA","W","W68",68,"C",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",4.974,-1.575,-1.453,2.68091,-1.561,-1.46,78,85,-1.146,9,9,45,0.157894736842105,"strand",-1.1,5.49,0.0004312203536006,24.2923336141533,24.2923334241599,24.2833096922897,14.1977442691074,46,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,4,2,0,0,4,-0.398936170212766,-0.375452196382429,0.0976445778305495,-0.26615515771526,-0.382198952879581,0.821052631578947,-0.943986820428336,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.124,"9:9","150/150","F:W",3.19016080361872,0.0035954281300595,1.09565968954934,2.91163472932995,3.91551977432164,465.531063220521,1.38546923679232,0.0007494070007895,3.12528225414311,2.71567844828345,1141.60089496884,0.0001645676755807,"lineage3","dr_mutations_pyrazinamide","CYS",0,"SAMN02403540","SRR1169265_SRR1167370_SRR1165624_SRR1169227","lineage3.1.1","za","South Africa","pnca_p.trp68cys","A","B","TRP","WA68","pnca_complex.pdb"
|
|
"W68C","L2","PZA","W","W68",68,"C",1,"XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",4.974,-1.575,-1.453,2.68091,-1.561,-1.46,78,85,-1.146,9,9,45,0.157894736842105,"strand",-1.1,5.49,0.0004312203536006,24.2923336141533,24.2923334241599,24.2833096922897,14.1977442691074,46,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,4,2,0,0,4,-0.398936170212766,-0.375452196382429,0.0976445778305495,-0.26615515771526,-0.382198952879581,0.821052631578947,-0.943986820428336,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.124,"9:9","150/150","F:W",3.19016080361872,0.0035954281300595,1.09565968954934,2.91163472932995,3.91551977432164,465.531063220521,1.38546923679232,0.0007494070007895,3.12528225414311,2.71567844828345,1141.60089496884,0.0001645676755807,"lineage2","dr_mutations_pyrazinamide","CYS",0,"SAMN03647592,SRR2100419","SRR2100419","lineage2.2.1","","","pnca_p.trp68cys","A","B","TRP","WA68","pnca_complex.pdb"
|
|
"W68C","L3","PZA","W","W68",68,"C",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",4.974,-1.575,-1.453,2.68091,-1.561,-1.46,78,85,-1.146,9,9,45,0.157894736842105,"strand",-1.1,5.49,0.0004312203536006,24.2923336141533,24.2923334241599,24.2833096922897,14.1977442691074,46,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,4,2,0,0,4,-0.398936170212766,-0.375452196382429,0.0976445778305495,-0.26615515771526,-0.382198952879581,0.821052631578947,-0.943986820428336,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.124,"9:9","150/150","F:W",3.19016080361872,0.0035954281300595,1.09565968954934,2.91163472932995,3.91551977432164,465.531063220521,1.38546923679232,0.0007494070007895,3.12528225414311,2.71567844828345,1141.60089496884,0.0001645676755807,"lineage3","dr_mutations_pyrazinamide","CYS",0,"SAMN02403590","SRR1165649_SRR1169186_SRR1167389_SRR1172046","lineage3.1.1","za","South Africa","pnca_p.trp68cys","A","B","TRP","WA68","pnca_complex.pdb"
|
|
"W68C","L3","PZA","W","W68",68,"C",1,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",4.974,-1.575,-1.453,2.68091,-1.561,-1.46,78,85,-1.146,9,9,45,0.157894736842105,"strand",-1.1,5.49,0.0004312203536006,24.2923336141533,24.2923334241599,24.2833096922897,14.1977442691074,46,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,4,2,0,0,4,-0.398936170212766,-0.375452196382429,0.0976445778305495,-0.26615515771526,-0.382198952879581,0.821052631578947,-0.943986820428336,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.124,"9:9","150/150","F:W",3.19016080361872,0.0035954281300595,1.09565968954934,2.91163472932995,3.91551977432164,465.531063220521,1.38546923679232,0.0007494070007895,3.12528225414311,2.71567844828345,1141.60089496884,0.0001645676755807,"lineage3","dr_mutations_pyrazinamide","CYS",0,"ERR2510449","ERR2510449","lineage3","pk","Pakistan","pnca_p.trp68cys","A","B","TRP","WA68","pnca_complex.pdb"
|
|
"W68C","L3","PZA","W","W68",68,"C",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",4.974,-1.575,-1.453,2.68091,-1.561,-1.46,78,85,-1.146,9,9,45,0.157894736842105,"strand",-1.1,5.49,0.0004312203536006,24.2923336141533,24.2923334241599,24.2833096922897,14.1977442691074,46,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,4,2,0,0,4,-0.398936170212766,-0.375452196382429,0.0976445778305495,-0.26615515771526,-0.382198952879581,0.821052631578947,-0.943986820428336,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.124,"9:9","150/150","F:W",3.19016080361872,0.0035954281300595,1.09565968954934,2.91163472932995,3.91551977432164,465.531063220521,1.38546923679232,0.0007494070007895,3.12528225414311,2.71567844828345,1141.60089496884,0.0001645676755807,"lineage3","dr_mutations_pyrazinamide","CYS",0,"SAMN02403517","SRR1173650_SRR1173386_SRR1167252_SRR1165230","lineage3.1.1","za","South Africa","pnca_p.trp68cys","A","B","TRP","WA68","pnca_complex.pdb"
|
|
"W68G","L2","PZA","W","W68",68,"G",NA,"XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",4.974,-2.125,-2.572,4.03792,-1.882,-3.08,86,91,-1.146,9,9,45,0.157894736842105,"strand",-1.1,5.49,0.0013655311197355,87.9339263024142,87.9339260820995,87.8998400324811,75.5173867602406,52,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,4,4,0,5,21,-0.538247213779129,-0.664599483204134,0.147069835881672,-0.320886615515772,-0.806282722513089,0.905263157894737,-0.943986820428336,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.124,"9:9","150/150","F:W",4.47658569248055,1.32290566590749e-05,1.02761623592683,4.35628159226488,18.1565285172187,1582.53238090538,1.94415646509946,2.3565519928076e-13,12.6277229739224,13.8702072448497,3588.35734387119,3.62203368500016e-18,"lineage2","dr_mutations_pyrazinamide","GLY",0,"SAMN02419585","SRR1159293_SRR1180989_SRR1181094_SRR1162491","lineage2.2.1","by","Belarus","pnca_p.trp68gly","A","B","TRP","WA68","pnca_complex.pdb"
|
|
"W68G","L2","PZA","W","W68",68,"G",1,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",4.974,-2.125,-2.572,4.03792,-1.882,-3.08,86,91,-1.146,9,9,45,0.157894736842105,"strand",-1.1,5.49,0.0013655311197355,87.9339263024142,87.9339260820995,87.8998400324811,75.5173867602406,52,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,4,4,0,5,21,-0.538247213779129,-0.664599483204134,0.147069835881672,-0.320886615515772,-0.806282722513089,0.905263157894737,-0.943986820428336,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.124,"9:9","150/150","F:W",4.47658569248055,1.32290566590749e-05,1.02761623592683,4.35628159226488,18.1565285172187,1582.53238090538,1.94415646509946,2.3565519928076e-13,12.6277229739224,13.8702072448497,3588.35734387119,3.62203368500016e-18,"lineage2","dr_mutations_pyrazinamide","GLY",0,"ERS457365","ERR551465_ERR551464","lineage2.2.1","uz","Nukus","pnca_p.trp68gly","A","B","TRP","WA68","pnca_complex.pdb"
|
|
"W68G","L2","PZA","W","W68",68,"G",1,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",4.974,-2.125,-2.572,4.03792,-1.882,-3.08,86,91,-1.146,9,9,45,0.157894736842105,"strand",-1.1,5.49,0.0013655311197355,87.9339263024142,87.9339260820995,87.8998400324811,75.5173867602406,52,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,4,4,0,5,21,-0.538247213779129,-0.664599483204134,0.147069835881672,-0.320886615515772,-0.806282722513089,0.905263157894737,-0.943986820428336,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.124,"9:9","150/150","F:W",4.47658569248055,1.32290566590749e-05,1.02761623592683,4.35628159226488,18.1565285172187,1582.53238090538,1.94415646509946,2.3565519928076e-13,12.6277229739224,13.8702072448497,3588.35734387119,3.62203368500016e-18,"lineage2","dr_mutations_pyrazinamide","GLY",0,"ERR2513994","ERR2513994","lineage2.2.1","gb","UK","pnca_p.trp68gly","A","B","TRP","WA68","pnca_complex.pdb"
|
|
"W68G","L2","PZA","W","W68",68,"G",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",4.974,-2.125,-2.572,4.03792,-1.882,-3.08,86,91,-1.146,9,9,45,0.157894736842105,"strand",-1.1,5.49,0.0013655311197355,87.9339263024142,87.9339260820995,87.8998400324811,75.5173867602406,52,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,4,4,0,5,21,-0.538247213779129,-0.664599483204134,0.147069835881672,-0.320886615515772,-0.806282722513089,0.905263157894737,-0.943986820428336,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.124,"9:9","150/150","F:W",4.47658569248055,1.32290566590749e-05,1.02761623592683,4.35628159226488,18.1565285172187,1582.53238090538,1.94415646509946,2.3565519928076e-13,12.6277229739224,13.8702072448497,3588.35734387119,3.62203368500016e-18,"lineage2","dr_mutations_pyrazinamide","GLY",0,"SAMN02419615","SRR1163330_SRR1163126_SRR1172405_SRR1169101","lineage2.2.1","by","Belarus","pnca_p.trp68gly","A","B","TRP","WA68","pnca_complex.pdb"
|
|
"W68G","L2","PZA","W","W68",68,"G",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",4.974,-2.125,-2.572,4.03792,-1.882,-3.08,86,91,-1.146,9,9,45,0.157894736842105,"strand",-1.1,5.49,0.0013655311197355,87.9339263024142,87.9339260820995,87.8998400324811,75.5173867602406,52,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,4,4,0,5,21,-0.538247213779129,-0.664599483204134,0.147069835881672,-0.320886615515772,-0.806282722513089,0.905263157894737,-0.943986820428336,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.124,"9:9","150/150","F:W",4.47658569248055,1.32290566590749e-05,1.02761623592683,4.35628159226488,18.1565285172187,1582.53238090538,1.94415646509946,2.3565519928076e-13,12.6277229739224,13.8702072448497,3588.35734387119,3.62203368500016e-18,"lineage2","dr_mutations_pyrazinamide","GLY",0,"SAMN02419538","SRR1159393_SRR1181150_SRR1159818_SRR1181305","lineage2.2.1","by","Belarus","pnca_p.trp68gly","A","B","TRP","WA68","pnca_complex.pdb"
|
|
"W68G","L2","PZA","W","W68",68,"G",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",4.974,-2.125,-2.572,4.03792,-1.882,-3.08,86,91,-1.146,9,9,45,0.157894736842105,"strand",-1.1,5.49,0.0013655311197355,87.9339263024142,87.9339260820995,87.8998400324811,75.5173867602406,52,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,4,4,0,5,21,-0.538247213779129,-0.664599483204134,0.147069835881672,-0.320886615515772,-0.806282722513089,0.905263157894737,-0.943986820428336,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.124,"9:9","150/150","F:W",4.47658569248055,1.32290566590749e-05,1.02761623592683,4.35628159226488,18.1565285172187,1582.53238090538,1.94415646509946,2.3565519928076e-13,12.6277229739224,13.8702072448497,3588.35734387119,3.62203368500016e-18,"lineage2","dr_mutations_pyrazinamide","GLY",0,"SAMN02058521","SRR958488_SRR924713","lineage2.2.1","by","Belarus","pnca_p.trp68gly","A","B","TRP","WA68","pnca_complex.pdb"
|
|
"W68G","L4","PZA","W","W68",68,"G",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",4.974,-2.125,-2.572,4.03792,-1.882,-3.08,86,91,-1.146,9,9,45,0.157894736842105,"strand",-1.1,5.49,0.0013655311197355,87.9339263024142,87.9339260820995,87.8998400324811,75.5173867602406,52,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,4,4,0,5,21,-0.538247213779129,-0.664599483204134,0.147069835881672,-0.320886615515772,-0.806282722513089,0.905263157894737,-0.943986820428336,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.124,"9:9","150/150","F:W",4.47658569248055,1.32290566590749e-05,1.02761623592683,4.35628159226488,18.1565285172187,1582.53238090538,1.94415646509946,2.3565519928076e-13,12.6277229739224,13.8702072448497,3588.35734387119,3.62203368500016e-18,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR3148199","ERR3148199","lineage4.3.3","mx","Mexico","pnca_p.trp68gly","A","B","TRP","WA68","pnca_complex.pdb"
|
|
"W68G","L3","PZA","W","W68",68,"G",1,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",4.974,-2.125,-2.572,4.03792,-1.882,-3.08,86,91,-1.146,9,9,45,0.157894736842105,"strand",-1.1,5.49,0.0013655311197355,87.9339263024142,87.9339260820995,87.8998400324811,75.5173867602406,52,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,4,4,0,5,21,-0.538247213779129,-0.664599483204134,0.147069835881672,-0.320886615515772,-0.806282722513089,0.905263157894737,-0.943986820428336,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.124,"9:9","150/150","F:W",4.47658569248055,1.32290566590749e-05,1.02761623592683,4.35628159226488,18.1565285172187,1582.53238090538,1.94415646509946,2.3565519928076e-13,12.6277229739224,13.8702072448497,3588.35734387119,3.62203368500016e-18,"lineage3","dr_mutations_pyrazinamide","GLY",0,"ERR2510625","ERR2510625","lineage3","pk","Pakistan","pnca_p.trp68gly","A","B","TRP","WA68","pnca_complex.pdb"
|
|
"W68G","L2","PZA","W","W68",68,"G",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",4.974,-2.125,-2.572,4.03792,-1.882,-3.08,86,91,-1.146,9,9,45,0.157894736842105,"strand",-1.1,5.49,0.0013655311197355,87.9339263024142,87.9339260820995,87.8998400324811,75.5173867602406,52,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,4,4,0,5,21,-0.538247213779129,-0.664599483204134,0.147069835881672,-0.320886615515772,-0.806282722513089,0.905263157894737,-0.943986820428336,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.124,"9:9","150/150","F:W",4.47658569248055,1.32290566590749e-05,1.02761623592683,4.35628159226488,18.1565285172187,1582.53238090538,1.94415646509946,2.3565519928076e-13,12.6277229739224,13.8702072448497,3588.35734387119,3.62203368500016e-18,"lineage2","dr_mutations_pyrazinamide","GLY",0,"SAMN02419541","SRR1159150_SRR1180957_SRR1159083_SRR1184034","lineage2.2.1","by","Belarus","pnca_p.trp68gly","A","B","TRP","WA68","pnca_complex.pdb"
|
|
"W68G","L2","PZA","W","W68",68,"G",NA,"XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",4.974,-2.125,-2.572,4.03792,-1.882,-3.08,86,91,-1.146,9,9,45,0.157894736842105,"strand",-1.1,5.49,0.0013655311197355,87.9339263024142,87.9339260820995,87.8998400324811,75.5173867602406,52,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,4,4,0,5,21,-0.538247213779129,-0.664599483204134,0.147069835881672,-0.320886615515772,-0.806282722513089,0.905263157894737,-0.943986820428336,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.124,"9:9","150/150","F:W",4.47658569248055,1.32290566590749e-05,1.02761623592683,4.35628159226488,18.1565285172187,1582.53238090538,1.94415646509946,2.3565519928076e-13,12.6277229739224,13.8702072448497,3588.35734387119,3.62203368500016e-18,"lineage2","dr_mutations_pyrazinamide","GLY",0,"SAMN02419593","SRR1162542_SRR1181208_SRR1159034_SRR1181241","lineage2.2.1","by","Belarus","pnca_p.trp68gly","A","B","TRP","WA68","pnca_complex.pdb"
|
|
"W68G","L2","PZA","W","W68",68,"G",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",4.974,-2.125,-2.572,4.03792,-1.882,-3.08,86,91,-1.146,9,9,45,0.157894736842105,"strand",-1.1,5.49,0.0013655311197355,87.9339263024142,87.9339260820995,87.8998400324811,75.5173867602406,52,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,4,4,0,5,21,-0.538247213779129,-0.664599483204134,0.147069835881672,-0.320886615515772,-0.806282722513089,0.905263157894737,-0.943986820428336,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.124,"9:9","150/150","F:W",4.47658569248055,1.32290566590749e-05,1.02761623592683,4.35628159226488,18.1565285172187,1582.53238090538,1.94415646509946,2.3565519928076e-13,12.6277229739224,13.8702072448497,3588.35734387119,3.62203368500016e-18,"lineage2","dr_mutations_pyrazinamide","GLY",0,"SAMN02419656","SRR1169025_SRR1163299_SRR1172411_SRR1163211","lineage2.2.1","by","Belarus","pnca_p.trp68gly","A","B","TRP","WA68","pnca_complex.pdb"
|
|
"W68G","L4","PZA","W","W68",68,"G",1,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",4.974,-2.125,-2.572,4.03792,-1.882,-3.08,86,91,-1.146,9,9,45,0.157894736842105,"strand",-1.1,5.49,0.0013655311197355,87.9339263024142,87.9339260820995,87.8998400324811,75.5173867602406,52,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,4,4,0,5,21,-0.538247213779129,-0.664599483204134,0.147069835881672,-0.320886615515772,-0.806282722513089,0.905263157894737,-0.943986820428336,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.124,"9:9","150/150","F:W",4.47658569248055,1.32290566590749e-05,1.02761623592683,4.35628159226488,18.1565285172187,1582.53238090538,1.94415646509946,2.3565519928076e-13,12.6277229739224,13.8702072448497,3588.35734387119,3.62203368500016e-18,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR067697,0373G-sc-2011-09-07T13:20:00Z-1276544","ERR067697","lineage4.1.2.1","ru","unknown,Russia,Samara","pnca_p.trp68gly","A","B","TRP","WA68","pnca_complex.pdb"
|
|
"W68G","L2","PZA","W","W68",68,"G",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",4.974,-2.125,-2.572,4.03792,-1.882,-3.08,86,91,-1.146,9,9,45,0.157894736842105,"strand",-1.1,5.49,0.0013655311197355,87.9339263024142,87.9339260820995,87.8998400324811,75.5173867602406,52,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,4,4,0,5,21,-0.538247213779129,-0.664599483204134,0.147069835881672,-0.320886615515772,-0.806282722513089,0.905263157894737,-0.943986820428336,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.124,"9:9","150/150","F:W",4.47658569248055,1.32290566590749e-05,1.02761623592683,4.35628159226488,18.1565285172187,1582.53238090538,1.94415646509946,2.3565519928076e-13,12.6277229739224,13.8702072448497,3588.35734387119,3.62203368500016e-18,"lineage2","dr_mutations_pyrazinamide","GLY",0,"SAMN02419596","SRR1181041_SRR1180951_SRR1159279_SRR1159003","lineage2.2.1","by","Belarus","pnca_p.trp68gly","A","B","TRP","WA68","pnca_complex.pdb"
|
|
"W68G","L4","PZA","W","W68",68,"G",1,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",4.974,-2.125,-2.572,4.03792,-1.882,-3.08,86,91,-1.146,9,9,45,0.157894736842105,"strand",-1.1,5.49,0.0013655311197355,87.9339263024142,87.9339260820995,87.8998400324811,75.5173867602406,52,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,4,4,0,5,21,-0.538247213779129,-0.664599483204134,0.147069835881672,-0.320886615515772,-0.806282722513089,0.905263157894737,-0.943986820428336,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.124,"9:9","150/150","F:W",4.47658569248055,1.32290566590749e-05,1.02761623592683,4.35628159226488,18.1565285172187,1582.53238090538,1.94415646509946,2.3565519928076e-13,12.6277229739224,13.8702072448497,3588.35734387119,3.62203368500016e-18,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR2517569","ERR2517569","lineage4.2.2","nl","Netherlands","pnca_p.trp68gly","A","B","TRP","WA68","pnca_complex.pdb"
|
|
"W68G","L2","PZA","W","W68",68,"G",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",4.974,-2.125,-2.572,4.03792,-1.882,-3.08,86,91,-1.146,9,9,45,0.157894736842105,"strand",-1.1,5.49,0.0013655311197355,87.9339263024142,87.9339260820995,87.8998400324811,75.5173867602406,52,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,4,4,0,5,21,-0.538247213779129,-0.664599483204134,0.147069835881672,-0.320886615515772,-0.806282722513089,0.905263157894737,-0.943986820428336,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.124,"9:9","150/150","F:W",4.47658569248055,1.32290566590749e-05,1.02761623592683,4.35628159226488,18.1565285172187,1582.53238090538,1.94415646509946,2.3565519928076e-13,12.6277229739224,13.8702072448497,3588.35734387119,3.62203368500016e-18,"lineage2","dr_mutations_pyrazinamide","GLY",0,"SAMN02058520","SRR924712_SRR958483","lineage2.2.1","by","Belarus","pnca_p.trp68gly","A","B","TRP","WA68","pnca_complex.pdb"
|
|
"W68G","L2","PZA","W","W68",68,"G",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",4.974,-2.125,-2.572,4.03792,-1.882,-3.08,86,91,-1.146,9,9,45,0.157894736842105,"strand",-1.1,5.49,0.0013655311197355,87.9339263024142,87.9339260820995,87.8998400324811,75.5173867602406,52,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,4,4,0,5,21,-0.538247213779129,-0.664599483204134,0.147069835881672,-0.320886615515772,-0.806282722513089,0.905263157894737,-0.943986820428336,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.124,"9:9","150/150","F:W",4.47658569248055,1.32290566590749e-05,1.02761623592683,4.35628159226488,18.1565285172187,1582.53238090538,1.94415646509946,2.3565519928076e-13,12.6277229739224,13.8702072448497,3588.35734387119,3.62203368500016e-18,"lineage2","dr_mutations_pyrazinamide","GLY",0,"SAMN02419534","SRR1181124_SRR1159959_SRR1181202_SRR1159661","lineage2.2.1","by","Belarus","pnca_p.trp68gly","A","B","TRP","WA68","pnca_complex.pdb"
|
|
"W68G","L2","PZA","W","W68",68,"G",NA,"XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",4.974,-2.125,-2.572,4.03792,-1.882,-3.08,86,91,-1.146,9,9,45,0.157894736842105,"strand",-1.1,5.49,0.0013655311197355,87.9339263024142,87.9339260820995,87.8998400324811,75.5173867602406,52,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,4,4,0,5,21,-0.538247213779129,-0.664599483204134,0.147069835881672,-0.320886615515772,-0.806282722513089,0.905263157894737,-0.943986820428336,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.124,"9:9","150/150","F:W",4.47658569248055,1.32290566590749e-05,1.02761623592683,4.35628159226488,18.1565285172187,1582.53238090538,1.94415646509946,2.3565519928076e-13,12.6277229739224,13.8702072448497,3588.35734387119,3.62203368500016e-18,"lineage2","dr_mutations_pyrazinamide","GLY",0,"SAMN02419659","SRR1169144_SRR1172291_SRR1163397_SRR1162966","lineage2.2.1","by","Belarus","pnca_p.trp68gly","A","B","TRP","WA68","pnca_complex.pdb"
|
|
"W68G","L2","PZA","W","W68",68,"G",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",4.974,-2.125,-2.572,4.03792,-1.882,-3.08,86,91,-1.146,9,9,45,0.157894736842105,"strand",-1.1,5.49,0.0013655311197355,87.9339263024142,87.9339260820995,87.8998400324811,75.5173867602406,52,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,4,4,0,5,21,-0.538247213779129,-0.664599483204134,0.147069835881672,-0.320886615515772,-0.806282722513089,0.905263157894737,-0.943986820428336,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.124,"9:9","150/150","F:W",4.47658569248055,1.32290566590749e-05,1.02761623592683,4.35628159226488,18.1565285172187,1582.53238090538,1.94415646509946,2.3565519928076e-13,12.6277229739224,13.8702072448497,3588.35734387119,3.62203368500016e-18,"lineage2","dr_mutations_pyrazinamide","GLY",0,"SAMN02419638","SRR1163002_SRR1169044_SRR1163354_SRR1172180","lineage2.2.1","by","Belarus","pnca_p.trp68gly","A","B","TRP","WA68","pnca_complex.pdb"
|
|
"W68G","L4","PZA","W","W68",68,"G",0,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",4.974,-2.125,-2.572,4.03792,-1.882,-3.08,86,91,-1.146,9,9,45,0.157894736842105,"strand",-1.1,5.49,0.0013655311197355,87.9339263024142,87.9339260820995,87.8998400324811,75.5173867602406,52,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,4,4,0,5,21,-0.538247213779129,-0.664599483204134,0.147069835881672,-0.320886615515772,-0.806282722513089,0.905263157894737,-0.943986820428336,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.124,"9:9","150/150","F:W",4.47658569248055,1.32290566590749e-05,1.02761623592683,4.35628159226488,18.1565285172187,1582.53238090538,1.94415646509946,2.3565519928076e-13,12.6277229739224,13.8702072448497,3588.35734387119,3.62203368500016e-18,"lineage4","dr_mutations_pyrazinamide","GLY",0,"0063V-sc-2012-02-09T18:55:23Z-1355133,ERR133800","ERR133800","lineage4.1.2.1","ru","Russia,Samara","pnca_p.trp68gly","A","B","TRP","WA68","pnca_complex.pdb"
|
|
"W68G","L2","PZA","W","W68",68,"G",NA,"XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",4.974,-2.125,-2.572,4.03792,-1.882,-3.08,86,91,-1.146,9,9,45,0.157894736842105,"strand",-1.1,5.49,0.0013655311197355,87.9339263024142,87.9339260820995,87.8998400324811,75.5173867602406,52,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,4,4,0,5,21,-0.538247213779129,-0.664599483204134,0.147069835881672,-0.320886615515772,-0.806282722513089,0.905263157894737,-0.943986820428336,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.124,"9:9","150/150","F:W",4.47658569248055,1.32290566590749e-05,1.02761623592683,4.35628159226488,18.1565285172187,1582.53238090538,1.94415646509946,2.3565519928076e-13,12.6277229739224,13.8702072448497,3588.35734387119,3.62203368500016e-18,"lineage2","dr_mutations_pyrazinamide","GLY",0,"SAMN02419571","SRR1181134_SRR1162535_SRR1181307_SRR1159121","lineage2.2.1","by","Belarus","pnca_p.trp68gly","A","B","TRP","WA68","pnca_complex.pdb"
|
|
"W68G","L2","PZA","W","W68",68,"G",1,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",4.974,-2.125,-2.572,4.03792,-1.882,-3.08,86,91,-1.146,9,9,45,0.157894736842105,"strand",-1.1,5.49,0.0013655311197355,87.9339263024142,87.9339260820995,87.8998400324811,75.5173867602406,52,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,4,4,0,5,21,-0.538247213779129,-0.664599483204134,0.147069835881672,-0.320886615515772,-0.806282722513089,0.905263157894737,-0.943986820428336,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.124,"9:9","150/150","F:W",4.47658569248055,1.32290566590749e-05,1.02761623592683,4.35628159226488,18.1565285172187,1582.53238090538,1.94415646509946,2.3565519928076e-13,12.6277229739224,13.8702072448497,3588.35734387119,3.62203368500016e-18,"lineage2","dr_mutations_pyrazinamide","GLY",0,"ERR2516960","ERR2516960","lineage2.2.1","gb","UK","pnca_p.trp68gly","A","B","TRP","WA68","pnca_complex.pdb"
|
|
"W68G","L2","PZA","W","W68",68,"G",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",4.974,-2.125,-2.572,4.03792,-1.882,-3.08,86,91,-1.146,9,9,45,0.157894736842105,"strand",-1.1,5.49,0.0013655311197355,87.9339263024142,87.9339260820995,87.8998400324811,75.5173867602406,52,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,4,4,0,5,21,-0.538247213779129,-0.664599483204134,0.147069835881672,-0.320886615515772,-0.806282722513089,0.905263157894737,-0.943986820428336,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.124,"9:9","150/150","F:W",4.47658569248055,1.32290566590749e-05,1.02761623592683,4.35628159226488,18.1565285172187,1582.53238090538,1.94415646509946,2.3565519928076e-13,12.6277229739224,13.8702072448497,3588.35734387119,3.62203368500016e-18,"lineage2","dr_mutations_pyrazinamide","GLY",0,"SAMN02058522","SRR958489_SRR924714","lineage2.2.1","by","Belarus","pnca_p.trp68gly","A","B","TRP","WA68","pnca_complex.pdb"
|
|
"W68G","L2","PZA","W","W68",68,"G",NA,"XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",4.974,-2.125,-2.572,4.03792,-1.882,-3.08,86,91,-1.146,9,9,45,0.157894736842105,"strand",-1.1,5.49,0.0013655311197355,87.9339263024142,87.9339260820995,87.8998400324811,75.5173867602406,52,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,4,4,0,5,21,-0.538247213779129,-0.664599483204134,0.147069835881672,-0.320886615515772,-0.806282722513089,0.905263157894737,-0.943986820428336,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.124,"9:9","150/150","F:W",4.47658569248055,1.32290566590749e-05,1.02761623592683,4.35628159226488,18.1565285172187,1582.53238090538,1.94415646509946,2.3565519928076e-13,12.6277229739224,13.8702072448497,3588.35734387119,3.62203368500016e-18,"lineage2","dr_mutations_pyrazinamide","GLY",0,"SAMN02419614","SRR1172351_SRR1169073_SRR1162947_SRR1166920","lineage2.2.1","by","Belarus","pnca_p.trp68gly","A","B","TRP","WA68","pnca_complex.pdb"
|
|
"W68G","L4","PZA","W","W68",68,"G",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",4.974,-2.125,-2.572,4.03792,-1.882,-3.08,86,91,-1.146,9,9,45,0.157894736842105,"strand",-1.1,5.49,0.0013655311197355,87.9339263024142,87.9339260820995,87.8998400324811,75.5173867602406,52,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,4,4,0,5,21,-0.538247213779129,-0.664599483204134,0.147069835881672,-0.320886615515772,-0.806282722513089,0.905263157894737,-0.943986820428336,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.124,"9:9","150/150","F:W",4.47658569248055,1.32290566590749e-05,1.02761623592683,4.35628159226488,18.1565285172187,1582.53238090538,1.94415646509946,2.3565519928076e-13,12.6277229739224,13.8702072448497,3588.35734387119,3.62203368500016e-18,"lineage4","dr_mutations_pyrazinamide","GLY",0,"SAMN02414970","SRR1165366_SRR1166935_SRR1162897_SRR1167151","lineage4.2.2","se","Sweden","pnca_p.trp68gly","A","B","TRP","WA68","pnca_complex.pdb"
|
|
"W68G","L2","PZA","W","W68",68,"G",NA,"XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",4.974,-2.125,-2.572,4.03792,-1.882,-3.08,86,91,-1.146,9,9,45,0.157894736842105,"strand",-1.1,5.49,0.0013655311197355,87.9339263024142,87.9339260820995,87.8998400324811,75.5173867602406,52,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,4,4,0,5,21,-0.538247213779129,-0.664599483204134,0.147069835881672,-0.320886615515772,-0.806282722513089,0.905263157894737,-0.943986820428336,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.124,"9:9","150/150","F:W",4.47658569248055,1.32290566590749e-05,1.02761623592683,4.35628159226488,18.1565285172187,1582.53238090538,1.94415646509946,2.3565519928076e-13,12.6277229739224,13.8702072448497,3588.35734387119,3.62203368500016e-18,"lineage2","dr_mutations_pyrazinamide","GLY",0,"SAMN02419655","SRR1162953_SRR1169128_SRR1172339_SRR1163423","lineage2.2.1","by","Belarus","pnca_p.trp68gly","A","B","TRP","WA68","pnca_complex.pdb"
|
|
"W68G","L2;L4","PZA","W","W68",68,"G",1,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",4.974,-2.125,-2.572,4.03792,-1.882,-3.08,86,91,-1.146,9,9,45,0.157894736842105,"strand",-1.1,5.49,0.0013655311197355,87.9339263024142,87.9339260820995,87.8998400324811,75.5173867602406,52,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,4,4,0,5,21,-0.538247213779129,-0.664599483204134,0.147069835881672,-0.320886615515772,-0.806282722513089,0.905263157894737,-0.943986820428336,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.124,"9:9","150/150","F:W",4.47658569248055,1.32290566590749e-05,1.02761623592683,4.35628159226488,18.1565285172187,1582.53238090538,1.94415646509946,2.3565519928076e-13,12.6277229739224,13.8702072448497,3588.35734387119,3.62203368500016e-18,"lineage2;lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR2510674","ERR2510674","lineage4.3.3;lineage2.2.1","it","Italy","pnca_p.trp68gly","A","B","TRP","WA68","pnca_complex.pdb"
|
|
"W68G","L4","PZA","W","W68",68,"G",1,"Pre-MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",4.974,-2.125,-2.572,4.03792,-1.882,-3.08,86,91,-1.146,9,9,45,0.157894736842105,"strand",-1.1,5.49,0.0013655311197355,87.9339263024142,87.9339260820995,87.8998400324811,75.5173867602406,52,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,4,4,0,5,21,-0.538247213779129,-0.664599483204134,0.147069835881672,-0.320886615515772,-0.806282722513089,0.905263157894737,-0.943986820428336,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.124,"9:9","150/150","F:W",4.47658569248055,1.32290566590749e-05,1.02761623592683,4.35628159226488,18.1565285172187,1582.53238090538,1.94415646509946,2.3565519928076e-13,12.6277229739224,13.8702072448497,3588.35734387119,3.62203368500016e-18,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR2041775","ERR2041775","lineage4.4.1.1","rs","Serbia","pnca_p.trp68gly","A","B","TRP","WA68","pnca_complex.pdb"
|
|
"W68G","L2","PZA","W","W68",68,"G",NA,"XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",4.974,-2.125,-2.572,4.03792,-1.882,-3.08,86,91,-1.146,9,9,45,0.157894736842105,"strand",-1.1,5.49,0.0013655311197355,87.9339263024142,87.9339260820995,87.8998400324811,75.5173867602406,52,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,4,4,0,5,21,-0.538247213779129,-0.664599483204134,0.147069835881672,-0.320886615515772,-0.806282722513089,0.905263157894737,-0.943986820428336,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.124,"9:9","150/150","F:W",4.47658569248055,1.32290566590749e-05,1.02761623592683,4.35628159226488,18.1565285172187,1582.53238090538,1.94415646509946,2.3565519928076e-13,12.6277229739224,13.8702072448497,3588.35734387119,3.62203368500016e-18,"lineage2","dr_mutations_pyrazinamide","GLY",0,"ERR502899","ERR502899","lineage2.2.1","","","pnca_p.trp68gly","A","B","TRP","WA68","pnca_complex.pdb"
|
|
"W68G","L2","PZA","W","W68",68,"G",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",4.974,-2.125,-2.572,4.03792,-1.882,-3.08,86,91,-1.146,9,9,45,0.157894736842105,"strand",-1.1,5.49,0.0013655311197355,87.9339263024142,87.9339260820995,87.8998400324811,75.5173867602406,52,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,4,4,0,5,21,-0.538247213779129,-0.664599483204134,0.147069835881672,-0.320886615515772,-0.806282722513089,0.905263157894737,-0.943986820428336,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.124,"9:9","150/150","F:W",4.47658569248055,1.32290566590749e-05,1.02761623592683,4.35628159226488,18.1565285172187,1582.53238090538,1.94415646509946,2.3565519928076e-13,12.6277229739224,13.8702072448497,3588.35734387119,3.62203368500016e-18,"lineage2","dr_mutations_pyrazinamide","GLY",0,"ERR2513436","ERR2513436","lineage2.2.1","gb","UK","pnca_p.trp68gly","A","B","TRP","WA68","pnca_complex.pdb"
|
|
"W68G","L4","PZA","W","W68",68,"G",1,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",4.974,-2.125,-2.572,4.03792,-1.882,-3.08,86,91,-1.146,9,9,45,0.157894736842105,"strand",-1.1,5.49,0.0013655311197355,87.9339263024142,87.9339260820995,87.8998400324811,75.5173867602406,52,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,4,4,0,5,21,-0.538247213779129,-0.664599483204134,0.147069835881672,-0.320886615515772,-0.806282722513089,0.905263157894737,-0.943986820428336,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.124,"9:9","150/150","F:W",4.47658569248055,1.32290566590749e-05,1.02761623592683,4.35628159226488,18.1565285172187,1582.53238090538,1.94415646509946,2.3565519928076e-13,12.6277229739224,13.8702072448497,3588.35734387119,3.62203368500016e-18,"lineage4","dr_mutations_pyrazinamide","GLY",0,"0977N-sc-2011-10-12T14:59:09Z-1289139,ERR108474","ERR108474","lineage4.1.2.1","ru","Russia,Samara","pnca_p.trp68gly","A","B","TRP","WA68","pnca_complex.pdb"
|
|
"W68G","L3","PZA","W","W68",68,"G",1,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",4.974,-2.125,-2.572,4.03792,-1.882,-3.08,86,91,-1.146,9,9,45,0.157894736842105,"strand",-1.1,5.49,0.0013655311197355,87.9339263024142,87.9339260820995,87.8998400324811,75.5173867602406,52,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,4,4,0,5,21,-0.538247213779129,-0.664599483204134,0.147069835881672,-0.320886615515772,-0.806282722513089,0.905263157894737,-0.943986820428336,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.124,"9:9","150/150","F:W",4.47658569248055,1.32290566590749e-05,1.02761623592683,4.35628159226488,18.1565285172187,1582.53238090538,1.94415646509946,2.3565519928076e-13,12.6277229739224,13.8702072448497,3588.35734387119,3.62203368500016e-18,"lineage3","dr_mutations_pyrazinamide","GLY",0,"ERR2510478","ERR2510478","lineage3","pk","Pakistan","pnca_p.trp68gly","A","B","TRP","WA68","pnca_complex.pdb"
|
|
"W68G","L4","PZA","W","W68",68,"G",1,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",4.974,-2.125,-2.572,4.03792,-1.882,-3.08,86,91,-1.146,9,9,45,0.157894736842105,"strand",-1.1,5.49,0.0013655311197355,87.9339263024142,87.9339260820995,87.8998400324811,75.5173867602406,52,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,4,4,0,5,21,-0.538247213779129,-0.664599483204134,0.147069835881672,-0.320886615515772,-0.806282722513089,0.905263157894737,-0.943986820428336,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.124,"9:9","150/150","F:W",4.47658569248055,1.32290566590749e-05,1.02761623592683,4.35628159226488,18.1565285172187,1582.53238090538,1.94415646509946,2.3565519928076e-13,12.6277229739224,13.8702072448497,3588.35734387119,3.62203368500016e-18,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR133942,0793N-sc-2012-02-09T18:57:10Z-1355275","ERR133942","lineage4.1.2.1","ru","Russia,Samara","pnca_p.trp68gly","A","B","TRP","WA68","pnca_complex.pdb"
|
|
"W68G","L4","PZA","W","W68",68,"G",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",4.974,-2.125,-2.572,4.03792,-1.882,-3.08,86,91,-1.146,9,9,45,0.157894736842105,"strand",-1.1,5.49,0.0013655311197355,87.9339263024142,87.9339260820995,87.8998400324811,75.5173867602406,52,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,4,4,0,5,21,-0.538247213779129,-0.664599483204134,0.147069835881672,-0.320886615515772,-0.806282722513089,0.905263157894737,-0.943986820428336,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.124,"9:9","150/150","F:W",4.47658569248055,1.32290566590749e-05,1.02761623592683,4.35628159226488,18.1565285172187,1582.53238090538,1.94415646509946,2.3565519928076e-13,12.6277229739224,13.8702072448497,3588.35734387119,3.62203368500016e-18,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR751545","ERR751545","lineage4.3.4.2","pe","","pnca_p.trp68gly","A","B","TRP","WA68","pnca_complex.pdb"
|
|
"W68G","L2","PZA","W","W68",68,"G",1,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",4.974,-2.125,-2.572,4.03792,-1.882,-3.08,86,91,-1.146,9,9,45,0.157894736842105,"strand",-1.1,5.49,0.0013655311197355,87.9339263024142,87.9339260820995,87.8998400324811,75.5173867602406,52,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,4,4,0,5,21,-0.538247213779129,-0.664599483204134,0.147069835881672,-0.320886615515772,-0.806282722513089,0.905263157894737,-0.943986820428336,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.124,"9:9","150/150","F:W",4.47658569248055,1.32290566590749e-05,1.02761623592683,4.35628159226488,18.1565285172187,1582.53238090538,1.94415646509946,2.3565519928076e-13,12.6277229739224,13.8702072448497,3588.35734387119,3.62203368500016e-18,"lineage2","dr_mutations_pyrazinamide","GLY",0,"ERS2592791","ERR2677446","lineage2.2.1","de","Germany","pnca_p.trp68gly","A","B","TRP","WA68","pnca_complex.pdb"
|
|
"W68G","L4","PZA","W","W68",68,"G",1,"Pre-MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",4.974,-2.125,-2.572,4.03792,-1.882,-3.08,86,91,-1.146,9,9,45,0.157894736842105,"strand",-1.1,5.49,0.0013655311197355,87.9339263024142,87.9339260820995,87.8998400324811,75.5173867602406,52,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,4,4,0,5,21,-0.538247213779129,-0.664599483204134,0.147069835881672,-0.320886615515772,-0.806282722513089,0.905263157894737,-0.943986820428336,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.124,"9:9","150/150","F:W",4.47658569248055,1.32290566590749e-05,1.02761623592683,4.35628159226488,18.1565285172187,1582.53238090538,1.94415646509946,2.3565519928076e-13,12.6277229739224,13.8702072448497,3588.35734387119,3.62203368500016e-18,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR2041774","ERR2041774","lineage4.4.1.1","rs","Serbia","pnca_p.trp68gly","A","B","TRP","WA68","pnca_complex.pdb"
|
|
"W68G","L4","PZA","W","W68",68,"G",1,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",4.974,-2.125,-2.572,4.03792,-1.882,-3.08,86,91,-1.146,9,9,45,0.157894736842105,"strand",-1.1,5.49,0.0013655311197355,87.9339263024142,87.9339260820995,87.8998400324811,75.5173867602406,52,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,4,4,0,5,21,-0.538247213779129,-0.664599483204134,0.147069835881672,-0.320886615515772,-0.806282722513089,0.905263157894737,-0.943986820428336,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.124,"9:9","150/150","F:W",4.47658569248055,1.32290566590749e-05,1.02761623592683,4.35628159226488,18.1565285172187,1582.53238090538,1.94415646509946,2.3565519928076e-13,12.6277229739224,13.8702072448497,3588.35734387119,3.62203368500016e-18,"lineage4","dr_mutations_pyrazinamide","GLY",0,"0309M-sc-2011-09-07T13:19:03Z-1276450,ERR067603","ERR067603","lineage4.1.2.1","ru","Russia,Samara","pnca_p.trp68gly","A","B","TRP","WA68","pnca_complex.pdb"
|
|
"W68G","L2","PZA","W","W68",68,"G",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",4.974,-2.125,-2.572,4.03792,-1.882,-3.08,86,91,-1.146,9,9,45,0.157894736842105,"strand",-1.1,5.49,0.0013655311197355,87.9339263024142,87.9339260820995,87.8998400324811,75.5173867602406,52,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,4,4,0,5,21,-0.538247213779129,-0.664599483204134,0.147069835881672,-0.320886615515772,-0.806282722513089,0.905263157894737,-0.943986820428336,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.124,"9:9","150/150","F:W",4.47658569248055,1.32290566590749e-05,1.02761623592683,4.35628159226488,18.1565285172187,1582.53238090538,1.94415646509946,2.3565519928076e-13,12.6277229739224,13.8702072448497,3588.35734387119,3.62203368500016e-18,"lineage2","dr_mutations_pyrazinamide","GLY",0,"SAMN02419674","SRR1163432_SRR1172449_SRR1163177_SRR1169070","lineage2.2.1","by","Belarus","pnca_p.trp68gly","A","B","TRP","WA68","pnca_complex.pdb"
|
|
"W68G","L2","PZA","W","W68",68,"G",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",4.974,-2.125,-2.572,4.03792,-1.882,-3.08,86,91,-1.146,9,9,45,0.157894736842105,"strand",-1.1,5.49,0.0013655311197355,87.9339263024142,87.9339260820995,87.8998400324811,75.5173867602406,52,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,4,4,0,5,21,-0.538247213779129,-0.664599483204134,0.147069835881672,-0.320886615515772,-0.806282722513089,0.905263157894737,-0.943986820428336,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.124,"9:9","150/150","F:W",4.47658569248055,1.32290566590749e-05,1.02761623592683,4.35628159226488,18.1565285172187,1582.53238090538,1.94415646509946,2.3565519928076e-13,12.6277229739224,13.8702072448497,3588.35734387119,3.62203368500016e-18,"lineage2","dr_mutations_pyrazinamide","GLY",0,"SAMN02419595","SRR1181082_SRR1158990_SRR1181159_SRR1162505","lineage2.2.1","by","Belarus","pnca_p.trp68gly","A","B","TRP","WA68","pnca_complex.pdb"
|
|
"W68G","L2","PZA","W","W68",68,"G",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",4.974,-2.125,-2.572,4.03792,-1.882,-3.08,86,91,-1.146,9,9,45,0.157894736842105,"strand",-1.1,5.49,0.0013655311197355,87.9339263024142,87.9339260820995,87.8998400324811,75.5173867602406,52,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,4,4,0,5,21,-0.538247213779129,-0.664599483204134,0.147069835881672,-0.320886615515772,-0.806282722513089,0.905263157894737,-0.943986820428336,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.124,"9:9","150/150","F:W",4.47658569248055,1.32290566590749e-05,1.02761623592683,4.35628159226488,18.1565285172187,1582.53238090538,1.94415646509946,2.3565519928076e-13,12.6277229739224,13.8702072448497,3588.35734387119,3.62203368500016e-18,"lineage2","dr_mutations_pyrazinamide","GLY",0,"SAMN02403560","SRR1165646_SRR1167382_SRR1169319_SRR1169246","lineage2.2.1","za","South Africa","pnca_p.trp68gly","A","B","TRP","WA68","pnca_complex.pdb"
|
|
"W68G","L2","PZA","W","W68",68,"G",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",4.974,-2.125,-2.572,4.03792,-1.882,-3.08,86,91,-1.146,9,9,45,0.157894736842105,"strand",-1.1,5.49,0.0013655311197355,87.9339263024142,87.9339260820995,87.8998400324811,75.5173867602406,52,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,4,4,0,5,21,-0.538247213779129,-0.664599483204134,0.147069835881672,-0.320886615515772,-0.806282722513089,0.905263157894737,-0.943986820428336,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.124,"9:9","150/150","F:W",4.47658569248055,1.32290566590749e-05,1.02761623592683,4.35628159226488,18.1565285172187,1582.53238090538,1.94415646509946,2.3565519928076e-13,12.6277229739224,13.8702072448497,3588.35734387119,3.62203368500016e-18,"lineage2","dr_mutations_pyrazinamide","GLY",0,"ERR2513229","ERR2513229","lineage2.2.1","gb","UK","pnca_p.trp68gly","A","B","TRP","WA68","pnca_complex.pdb"
|
|
"W68G","L2","PZA","W","W68",68,"G",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",4.974,-2.125,-2.572,4.03792,-1.882,-3.08,86,91,-1.146,9,9,45,0.157894736842105,"strand",-1.1,5.49,0.0013655311197355,87.9339263024142,87.9339260820995,87.8998400324811,75.5173867602406,52,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,4,4,0,5,21,-0.538247213779129,-0.664599483204134,0.147069835881672,-0.320886615515772,-0.806282722513089,0.905263157894737,-0.943986820428336,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.124,"9:9","150/150","F:W",4.47658569248055,1.32290566590749e-05,1.02761623592683,4.35628159226488,18.1565285172187,1582.53238090538,1.94415646509946,2.3565519928076e-13,12.6277229739224,13.8702072448497,3588.35734387119,3.62203368500016e-18,"lineage2","dr_mutations_pyrazinamide","GLY",0,"ERR2516390","ERR2516390","lineage2.2.1","be","Belgium","pnca_p.trp68gly","A","B","TRP","WA68","pnca_complex.pdb"
|
|
"W68G","L4","PZA","W","W68",68,"G",1,"XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",4.974,-2.125,-2.572,4.03792,-1.882,-3.08,86,91,-1.146,9,9,45,0.157894736842105,"strand",-1.1,5.49,0.0013655311197355,87.9339263024142,87.9339260820995,87.8998400324811,75.5173867602406,52,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,4,4,0,5,21,-0.538247213779129,-0.664599483204134,0.147069835881672,-0.320886615515772,-0.806282722513089,0.905263157894737,-0.943986820428336,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.124,"9:9","150/150","F:W",4.47658569248055,1.32290566590749e-05,1.02761623592683,4.35628159226488,18.1565285172187,1582.53238090538,1.94415646509946,2.3565519928076e-13,12.6277229739224,13.8702072448497,3588.35734387119,3.62203368500016e-18,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR2516514","ERR2516514","lineage4.1.2","pe","Peru","pnca_p.trp68gly","A","B","TRP","WA68","pnca_complex.pdb"
|
|
"W68G","L2","PZA","W","W68",68,"G",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",4.974,-2.125,-2.572,4.03792,-1.882,-3.08,86,91,-1.146,9,9,45,0.157894736842105,"strand",-1.1,5.49,0.0013655311197355,87.9339263024142,87.9339260820995,87.8998400324811,75.5173867602406,52,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,4,4,0,5,21,-0.538247213779129,-0.664599483204134,0.147069835881672,-0.320886615515772,-0.806282722513089,0.905263157894737,-0.943986820428336,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.124,"9:9","150/150","F:W",4.47658569248055,1.32290566590749e-05,1.02761623592683,4.35628159226488,18.1565285172187,1582.53238090538,1.94415646509946,2.3565519928076e-13,12.6277229739224,13.8702072448497,3588.35734387119,3.62203368500016e-18,"lineage2","dr_mutations_pyrazinamide","GLY",0,"SAMN02419562","SRR1158874_SRR1181154_SRR1181073_SRR1159351","lineage2.2.1","by","Belarus","pnca_p.trp68gly","A","B","TRP","WA68","pnca_complex.pdb"
|
|
"W68G","L2","PZA","W","W68",68,"G",NA,"XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",4.974,-2.125,-2.572,4.03792,-1.882,-3.08,86,91,-1.146,9,9,45,0.157894736842105,"strand",-1.1,5.49,0.0013655311197355,87.9339263024142,87.9339260820995,87.8998400324811,75.5173867602406,52,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,4,4,0,5,21,-0.538247213779129,-0.664599483204134,0.147069835881672,-0.320886615515772,-0.806282722513089,0.905263157894737,-0.943986820428336,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.124,"9:9","150/150","F:W",4.47658569248055,1.32290566590749e-05,1.02761623592683,4.35628159226488,18.1565285172187,1582.53238090538,1.94415646509946,2.3565519928076e-13,12.6277229739224,13.8702072448497,3588.35734387119,3.62203368500016e-18,"lineage2","dr_mutations_pyrazinamide","GLY",0,"SAMN02419649","SRR1163405_SRR1172064_SRR1169142_SRR1163114","lineage2.2.1","by","Belarus","pnca_p.trp68gly","A","B","TRP","WA68","pnca_complex.pdb"
|
|
"W68G","L2","PZA","W","W68",68,"G",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",4.974,-2.125,-2.572,4.03792,-1.882,-3.08,86,91,-1.146,9,9,45,0.157894736842105,"strand",-1.1,5.49,0.0013655311197355,87.9339263024142,87.9339260820995,87.8998400324811,75.5173867602406,52,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,4,4,0,5,21,-0.538247213779129,-0.664599483204134,0.147069835881672,-0.320886615515772,-0.806282722513089,0.905263157894737,-0.943986820428336,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.124,"9:9","150/150","F:W",4.47658569248055,1.32290566590749e-05,1.02761623592683,4.35628159226488,18.1565285172187,1582.53238090538,1.94415646509946,2.3565519928076e-13,12.6277229739224,13.8702072448497,3588.35734387119,3.62203368500016e-18,"lineage2","dr_mutations_pyrazinamide","GLY",0,"SAMN02086226","SRR924718_SRR958501","lineage2.2.1","by","Belarus","pnca_p.trp68gly","A","B","TRP","WA68","pnca_complex.pdb"
|
|
"W68G","L4","PZA","W","W68",68,"G",1,"XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",4.974,-2.125,-2.572,4.03792,-1.882,-3.08,86,91,-1.146,9,9,45,0.157894736842105,"strand",-1.1,5.49,0.0013655311197355,87.9339263024142,87.9339260820995,87.8998400324811,75.5173867602406,52,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,4,4,0,5,21,-0.538247213779129,-0.664599483204134,0.147069835881672,-0.320886615515772,-0.806282722513089,0.905263157894737,-0.943986820428336,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.124,"9:9","150/150","F:W",4.47658569248055,1.32290566590749e-05,1.02761623592683,4.35628159226488,18.1565285172187,1582.53238090538,1.94415646509946,2.3565519928076e-13,12.6277229739224,13.8702072448497,3588.35734387119,3.62203368500016e-18,"lineage4","dr_mutations_pyrazinamide","GLY",0,"0988A-sc-2011-10-12T14:59:13Z-1289145,ERR108480","ERR108480","lineage4.1.2.1","ru","Russia,Samara","pnca_p.trp68gly","A","B","TRP","WA68","pnca_complex.pdb"
|
|
"W68G","L2","PZA","W","W68",68,"G",NA,"XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",4.974,-2.125,-2.572,4.03792,-1.882,-3.08,86,91,-1.146,9,9,45,0.157894736842105,"strand",-1.1,5.49,0.0013655311197355,87.9339263024142,87.9339260820995,87.8998400324811,75.5173867602406,52,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,4,4,0,5,21,-0.538247213779129,-0.664599483204134,0.147069835881672,-0.320886615515772,-0.806282722513089,0.905263157894737,-0.943986820428336,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.124,"9:9","150/150","F:W",4.47658569248055,1.32290566590749e-05,1.02761623592683,4.35628159226488,18.1565285172187,1582.53238090538,1.94415646509946,2.3565519928076e-13,12.6277229739224,13.8702072448497,3588.35734387119,3.62203368500016e-18,"lineage2","dr_mutations_pyrazinamide","GLY",0,"SAMN02419567","SRR1181205_SRR1181278_SRR1159283_SRR1159108","lineage2.2.1","by","Belarus","pnca_p.trp68gly","A","B","TRP","WA68","pnca_complex.pdb"
|
|
"W68G","L2","PZA","W","W68",68,"G",NA,"XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",4.974,-2.125,-2.572,4.03792,-1.882,-3.08,86,91,-1.146,9,9,45,0.157894736842105,"strand",-1.1,5.49,0.0013655311197355,87.9339263024142,87.9339260820995,87.8998400324811,75.5173867602406,52,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,4,4,0,5,21,-0.538247213779129,-0.664599483204134,0.147069835881672,-0.320886615515772,-0.806282722513089,0.905263157894737,-0.943986820428336,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.124,"9:9","150/150","F:W",4.47658569248055,1.32290566590749e-05,1.02761623592683,4.35628159226488,18.1565285172187,1582.53238090538,1.94415646509946,2.3565519928076e-13,12.6277229739224,13.8702072448497,3588.35734387119,3.62203368500016e-18,"lineage2","dr_mutations_pyrazinamide","GLY",0,"SAMN02419650","SRR1172392_SRR1169086_SRR1163080_SRR1163349","lineage2.2.1","by","Belarus","pnca_p.trp68gly","A","B","TRP","WA68","pnca_complex.pdb"
|
|
"W68G","L2","PZA","W","W68",68,"G",1,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",4.974,-2.125,-2.572,4.03792,-1.882,-3.08,86,91,-1.146,9,9,45,0.157894736842105,"strand",-1.1,5.49,0.0013655311197355,87.9339263024142,87.9339260820995,87.8998400324811,75.5173867602406,52,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,4,4,0,5,21,-0.538247213779129,-0.664599483204134,0.147069835881672,-0.320886615515772,-0.806282722513089,0.905263157894737,-0.943986820428336,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.124,"9:9","150/150","F:W",4.47658569248055,1.32290566590749e-05,1.02761623592683,4.35628159226488,18.1565285172187,1582.53238090538,1.94415646509946,2.3565519928076e-13,12.6277229739224,13.8702072448497,3588.35734387119,3.62203368500016e-18,"lineage2","dr_mutations_pyrazinamide","GLY",0,"ERR2516899","ERR2516899","lineage2.2.1","gb","UK","pnca_p.trp68gly","A","B","TRP","WA68","pnca_complex.pdb"
|
|
"W68G","L2","PZA","W","W68",68,"G",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",4.974,-2.125,-2.572,4.03792,-1.882,-3.08,86,91,-1.146,9,9,45,0.157894736842105,"strand",-1.1,5.49,0.0013655311197355,87.9339263024142,87.9339260820995,87.8998400324811,75.5173867602406,52,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,4,4,0,5,21,-0.538247213779129,-0.664599483204134,0.147069835881672,-0.320886615515772,-0.806282722513089,0.905263157894737,-0.943986820428336,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.124,"9:9","150/150","F:W",4.47658569248055,1.32290566590749e-05,1.02761623592683,4.35628159226488,18.1565285172187,1582.53238090538,1.94415646509946,2.3565519928076e-13,12.6277229739224,13.8702072448497,3588.35734387119,3.62203368500016e-18,"lineage2","dr_mutations_pyrazinamide","GLY",0,"SAMN02419651","SRR1163139_SRR1163298_SRR1172059_SRR1169135","lineage2.2.1","by","Belarus","pnca_p.trp68gly","A","B","TRP","WA68","pnca_complex.pdb"
|
|
"W68G","L2","PZA","W","W68",68,"G",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",4.974,-2.125,-2.572,4.03792,-1.882,-3.08,86,91,-1.146,9,9,45,0.157894736842105,"strand",-1.1,5.49,0.0013655311197355,87.9339263024142,87.9339260820995,87.8998400324811,75.5173867602406,52,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,4,4,0,5,21,-0.538247213779129,-0.664599483204134,0.147069835881672,-0.320886615515772,-0.806282722513089,0.905263157894737,-0.943986820428336,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.124,"9:9","150/150","F:W",4.47658569248055,1.32290566590749e-05,1.02761623592683,4.35628159226488,18.1565285172187,1582.53238090538,1.94415646509946,2.3565519928076e-13,12.6277229739224,13.8702072448497,3588.35734387119,3.62203368500016e-18,"lineage2","dr_mutations_pyrazinamide","GLY",0,"SAMN02419658","SRR1163103_SRR1166917_SRR1174821_SRR1169143","lineage2.2.1","by","Belarus","pnca_p.trp68gly","A","B","TRP","WA68","pnca_complex.pdb"
|
|
"W68G","L4","PZA","W","W68",68,"G",1,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",4.974,-2.125,-2.572,4.03792,-1.882,-3.08,86,91,-1.146,9,9,45,0.157894736842105,"strand",-1.1,5.49,0.0013655311197355,87.9339263024142,87.9339260820995,87.8998400324811,75.5173867602406,52,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,4,4,0,5,21,-0.538247213779129,-0.664599483204134,0.147069835881672,-0.320886615515772,-0.806282722513089,0.905263157894737,-0.943986820428336,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.124,"9:9","150/150","F:W",4.47658569248055,1.32290566590749e-05,1.02761623592683,4.35628159226488,18.1565285172187,1582.53238090538,1.94415646509946,2.3565519928076e-13,12.6277229739224,13.8702072448497,3588.35734387119,3.62203368500016e-18,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR133878,0529B-sc-2012-02-09T18:56:19Z-1355211","ERR133878","lineage4.1.2.1","ru","Russia,Samara","pnca_p.trp68gly","A","B","TRP","WA68","pnca_complex.pdb"
|
|
"W68G","L4","PZA","W","W68",68,"G",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",4.974,-2.125,-2.572,4.03792,-1.882,-3.08,86,91,-1.146,9,9,45,0.157894736842105,"strand",-1.1,5.49,0.0013655311197355,87.9339263024142,87.9339260820995,87.8998400324811,75.5173867602406,52,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,4,4,0,5,21,-0.538247213779129,-0.664599483204134,0.147069835881672,-0.320886615515772,-0.806282722513089,0.905263157894737,-0.943986820428336,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.124,"9:9","150/150","F:W",4.47658569248055,1.32290566590749e-05,1.02761623592683,4.35628159226488,18.1565285172187,1582.53238090538,1.94415646509946,2.3565519928076e-13,12.6277229739224,13.8702072448497,3588.35734387119,3.62203368500016e-18,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR2446183","ERR2446183","lineage4.2.2","nl","Netherlands","pnca_p.trp68gly","A","B","TRP","WA68","pnca_complex.pdb"
|
|
"W68G","L2","PZA","W","W68",68,"G",NA,"Pre-MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",4.974,-2.125,-2.572,4.03792,-1.882,-3.08,86,91,-1.146,9,9,45,0.157894736842105,"strand",-1.1,5.49,0.0013655311197355,87.9339263024142,87.9339260820995,87.8998400324811,75.5173867602406,52,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,4,4,0,5,21,-0.538247213779129,-0.664599483204134,0.147069835881672,-0.320886615515772,-0.806282722513089,0.905263157894737,-0.943986820428336,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.124,"9:9","150/150","F:W",4.47658569248055,1.32290566590749e-05,1.02761623592683,4.35628159226488,18.1565285172187,1582.53238090538,1.94415646509946,2.3565519928076e-13,12.6277229739224,13.8702072448497,3588.35734387119,3.62203368500016e-18,"lineage2","dr_mutations_pyrazinamide","GLY",0,"SRR671756,BGI_FJ09114","SRR671756","lineage2.2.1","cn","China","pnca_p.trp68gly","A","B","TRP","WA68","pnca_complex.pdb"
|
|
"W68G","L4","PZA","W","W68",68,"G",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",4.974,-2.125,-2.572,4.03792,-1.882,-3.08,86,91,-1.146,9,9,45,0.157894736842105,"strand",-1.1,5.49,0.0013655311197355,87.9339263024142,87.9339260820995,87.8998400324811,75.5173867602406,52,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,4,4,0,5,21,-0.538247213779129,-0.664599483204134,0.147069835881672,-0.320886615515772,-0.806282722513089,0.905263157894737,-0.943986820428336,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.124,"9:9","150/150","F:W",4.47658569248055,1.32290566590749e-05,1.02761623592683,4.35628159226488,18.1565285172187,1582.53238090538,1.94415646509946,2.3565519928076e-13,12.6277229739224,13.8702072448497,3588.35734387119,3.62203368500016e-18,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR3275336","ERR3275336","lineage4.2.2","nl","Netherlands","pnca_p.trp68gly","A","B","TRP","WA68","pnca_complex.pdb"
|
|
"W68G","L2","PZA","W","W68",68,"G",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",4.974,-2.125,-2.572,4.03792,-1.882,-3.08,86,91,-1.146,9,9,45,0.157894736842105,"strand",-1.1,5.49,0.0013655311197355,87.9339263024142,87.9339260820995,87.8998400324811,75.5173867602406,52,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,4,4,0,5,21,-0.538247213779129,-0.664599483204134,0.147069835881672,-0.320886615515772,-0.806282722513089,0.905263157894737,-0.943986820428336,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.124,"9:9","150/150","F:W",4.47658569248055,1.32290566590749e-05,1.02761623592683,4.35628159226488,18.1565285172187,1582.53238090538,1.94415646509946,2.3565519928076e-13,12.6277229739224,13.8702072448497,3588.35734387119,3.62203368500016e-18,"lineage2","dr_mutations_pyrazinamide","GLY",0,"SAMN02419631","SRR1163198_SRR1163314_SRR1172117_SRR1169074","lineage2.2.1","by","Belarus","pnca_p.trp68gly","A","B","TRP","WA68","pnca_complex.pdb"
|
|
"W68L","L2","PZA","W","W68",68,"L",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",4.974,-2.242,-1.622,0.192132,-1.096,-1.35,84,91,-1.146,9,9,45,0.157894736842105,"strand",-1.1,5.49,NA,NA,NA,NA,NA,30,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-3,0,-1,-3,0,0,0,2,-0.567882472137791,-0.419121447028424,0.00699786566044333,-0.186871270247229,-0.353403141361257,0.884210526315789,-0.943986820428336,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.124,"9:9","150/150","F:W",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage2","dr_mutations_pyrazinamide","LEU",0,"BGI_SH415,SRR671826","SRR671826","lineage2.2.1","cn","China","pnca_p.trp68leu","A","B","TRP","WA68","pnca_complex.pdb"
|
|
"W68R","L2;L4","PZA","W","W68",68,"R",NA,"Pre-MDR","DM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",4.974,-0.576,-1.608,0.0790982,-1.263,-1.5,89,91,-1.146,9,9,45,0.157894736842105,"strand",-1.1,5.49,0.0020123616501365,132.405612244898,132.40553086776,132.608758225219,119.023328875182,-18,-32,0,0,-32,0,0,0,0,-2,0,-2,0,0,0,0,0,-1,0,-4,3,2,0,0,-2,-0.145896656534954,-0.415503875968992,0.00288092861981803,-0.215345268542199,-0.392670157068063,0.936842105263158,-0.943986820428336,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.124,"9:9","150/150","F:W",4.88586941655608,1.59295080619135e-06,1.01805765099734,4.79920701128237,28.2126225203342,2362.8544732838,2.12190639382976,4.03470202806197e-20,19.3941885333947,21.793565475171,5246.53379470447,1.03505008297772e-27,"lineage2;lineage4","dr_mutations_pyrazinamide","ARG",0,"SRS797298","SRR1723828","lineage4;lineage2.2.1","cn","China:Hubei","pnca_p.trp68arg","A","B","TRP","WA68","pnca_complex.pdb"
|
|
"W68R","L2","PZA","W","W68",68,"R",1,"MDR","DM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",4.974,-0.576,-1.608,0.0790982,-1.263,-1.5,89,91,-1.146,9,9,45,0.157894736842105,"strand",-1.1,5.49,0.0020123616501365,132.405612244898,132.40553086776,132.608758225219,119.023328875182,-18,-32,0,0,-32,0,0,0,0,-2,0,-2,0,0,0,0,0,-1,0,-4,3,2,0,0,-2,-0.145896656534954,-0.415503875968992,0.00288092861981803,-0.215345268542199,-0.392670157068063,0.936842105263158,-0.943986820428336,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.124,"9:9","150/150","F:W",4.88586941655608,1.59295080619135e-06,1.01805765099734,4.79920701128237,28.2126225203342,2362.8544732838,2.12190639382976,4.03470202806197e-20,19.3941885333947,21.793565475171,5246.53379470447,1.03505008297772e-27,"lineage2","dr_mutations_pyrazinamide","ARG",0,"14MT_13359","SRR5525998","lineage2.2.1.1","pg","","pnca_p.trp68arg","A","B","TRP","WA68","pnca_complex.pdb"
|
|
"W68R","L2","PZA","W","W68",68,"R",0,"XDR","DM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",4.974,-0.576,-1.608,0.0790982,-1.263,-1.5,89,91,-1.146,9,9,45,0.157894736842105,"strand",-1.1,5.49,0.0020123616501365,132.405612244898,132.40553086776,132.608758225219,119.023328875182,-18,-32,0,0,-32,0,0,0,0,-2,0,-2,0,0,0,0,0,-1,0,-4,3,2,0,0,-2,-0.145896656534954,-0.415503875968992,0.00288092861981803,-0.215345268542199,-0.392670157068063,0.936842105263158,-0.943986820428336,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.124,"9:9","150/150","F:W",4.88586941655608,1.59295080619135e-06,1.01805765099734,4.79920701128237,28.2126225203342,2362.8544732838,2.12190639382976,4.03470202806197e-20,19.3941885333947,21.793565475171,5246.53379470447,1.03505008297772e-27,"lineage2","dr_mutations_pyrazinamide","ARG",0,"ERR133901,0668C-sc-2012-02-09T18:56:41Z-1355234","ERR133901","lineage2.2.1","ru","Russia,Samara","pnca_p.trp68arg","A","B","TRP","WA68","pnca_complex.pdb"
|
|
"W68R","L4","PZA","W","W68",68,"R",NA,"Pre-MDR","DM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",4.974,-0.576,-1.608,0.0790982,-1.263,-1.5,89,91,-1.146,9,9,45,0.157894736842105,"strand",-1.1,5.49,0.0020123616501365,132.405612244898,132.40553086776,132.608758225219,119.023328875182,-18,-32,0,0,-32,0,0,0,0,-2,0,-2,0,0,0,0,0,-1,0,-4,3,2,0,0,-2,-0.145896656534954,-0.415503875968992,0.00288092861981803,-0.215345268542199,-0.392670157068063,0.936842105263158,-0.943986820428336,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.124,"9:9","150/150","F:W",4.88586941655608,1.59295080619135e-06,1.01805765099734,4.79920701128237,28.2126225203342,2362.8544732838,2.12190639382976,4.03470202806197e-20,19.3941885333947,21.793565475171,5246.53379470447,1.03505008297772e-27,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERR1035312","ERR1035312","lineage4.3.3","br","Brazil","pnca_p.trp68arg","A","B","TRP","WA68","pnca_complex.pdb"
|
|
"W68R","L2","PZA","W","W68",68,"R",NA,"MDR","DM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",4.974,-0.576,-1.608,0.0790982,-1.263,-1.5,89,91,-1.146,9,9,45,0.157894736842105,"strand",-1.1,5.49,0.0020123616501365,132.405612244898,132.40553086776,132.608758225219,119.023328875182,-18,-32,0,0,-32,0,0,0,0,-2,0,-2,0,0,0,0,0,-1,0,-4,3,2,0,0,-2,-0.145896656534954,-0.415503875968992,0.00288092861981803,-0.215345268542199,-0.392670157068063,0.936842105263158,-0.943986820428336,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.124,"9:9","150/150","F:W",4.88586941655608,1.59295080619135e-06,1.01805765099734,4.79920701128237,28.2126225203342,2362.8544732838,2.12190639382976,4.03470202806197e-20,19.3941885333947,21.793565475171,5246.53379470447,1.03505008297772e-27,"lineage2","dr_mutations_pyrazinamide","ARG",0,"SAMN03653291,SRS936038","SRR2024992","lineage2.2.1","cn","China","pnca_p.trp68arg","A","B","TRP","WA68","pnca_complex.pdb"
|
|
"W68R","L2","PZA","W","W68",68,"R",NA,"Pre-MDR","DM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",4.974,-0.576,-1.608,0.0790982,-1.263,-1.5,89,91,-1.146,9,9,45,0.157894736842105,"strand",-1.1,5.49,0.0020123616501365,132.405612244898,132.40553086776,132.608758225219,119.023328875182,-18,-32,0,0,-32,0,0,0,0,-2,0,-2,0,0,0,0,0,-1,0,-4,3,2,0,0,-2,-0.145896656534954,-0.415503875968992,0.00288092861981803,-0.215345268542199,-0.392670157068063,0.936842105263158,-0.943986820428336,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.124,"9:9","150/150","F:W",4.88586941655608,1.59295080619135e-06,1.01805765099734,4.79920701128237,28.2126225203342,2362.8544732838,2.12190639382976,4.03470202806197e-20,19.3941885333947,21.793565475171,5246.53379470447,1.03505008297772e-27,"lineage2","dr_mutations_pyrazinamide","ARG",0,"SRR5065397","SRR5065397","lineage2.2.1","vn","Vietnam","pnca_p.trp68arg","A","B","TRP","WA68","pnca_complex.pdb"
|
|
"W68R","L2","PZA","W","W68",68,"R",NA,"MDR","DM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",4.974,-0.576,-1.608,0.0790982,-1.263,-1.5,89,91,-1.146,9,9,45,0.157894736842105,"strand",-1.1,5.49,0.0020123616501365,132.405612244898,132.40553086776,132.608758225219,119.023328875182,-18,-32,0,0,-32,0,0,0,0,-2,0,-2,0,0,0,0,0,-1,0,-4,3,2,0,0,-2,-0.145896656534954,-0.415503875968992,0.00288092861981803,-0.215345268542199,-0.392670157068063,0.936842105263158,-0.943986820428336,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.124,"9:9","150/150","F:W",4.88586941655608,1.59295080619135e-06,1.01805765099734,4.79920701128237,28.2126225203342,2362.8544732838,2.12190639382976,4.03470202806197e-20,19.3941885333947,21.793565475171,5246.53379470447,1.03505008297772e-27,"lineage2","dr_mutations_pyrazinamide","ARG",0,"SRR5067222","SRR5067222","lineage2.2.1","vn","Vietnam","pnca_p.trp68arg","A","B","TRP","WA68","pnca_complex.pdb"
|
|
"W68R","L2","PZA","W","W68",68,"R",1,"Pre-XDR","DM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",4.974,-0.576,-1.608,0.0790982,-1.263,-1.5,89,91,-1.146,9,9,45,0.157894736842105,"strand",-1.1,5.49,0.0020123616501365,132.405612244898,132.40553086776,132.608758225219,119.023328875182,-18,-32,0,0,-32,0,0,0,0,-2,0,-2,0,0,0,0,0,-1,0,-4,3,2,0,0,-2,-0.145896656534954,-0.415503875968992,0.00288092861981803,-0.215345268542199,-0.392670157068063,0.936842105263158,-0.943986820428336,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.124,"9:9","150/150","F:W",4.88586941655608,1.59295080619135e-06,1.01805765099734,4.79920701128237,28.2126225203342,2362.8544732838,2.12190639382976,4.03470202806197e-20,19.3941885333947,21.793565475171,5246.53379470447,1.03505008297772e-27,"lineage2","dr_mutations_pyrazinamide","ARG",0,"SAMEA2534128,ERS457530","ERR551697_ERR551698","lineage2.2.1","uz","Nukus","pnca_p.trp68arg","A","B","TRP","WA68","pnca_complex.pdb"
|
|
"W68R","L2","PZA","W","W68",68,"R",NA,"MDR","DM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",4.974,-0.576,-1.608,0.0790982,-1.263,-1.5,89,91,-1.146,9,9,45,0.157894736842105,"strand",-1.1,5.49,0.0020123616501365,132.405612244898,132.40553086776,132.608758225219,119.023328875182,-18,-32,0,0,-32,0,0,0,0,-2,0,-2,0,0,0,0,0,-1,0,-4,3,2,0,0,-2,-0.145896656534954,-0.415503875968992,0.00288092861981803,-0.215345268542199,-0.392670157068063,0.936842105263158,-0.943986820428336,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.124,"9:9","150/150","F:W",4.88586941655608,1.59295080619135e-06,1.01805765099734,4.79920701128237,28.2126225203342,2362.8544732838,2.12190639382976,4.03470202806197e-20,19.3941885333947,21.793565475171,5246.53379470447,1.03505008297772e-27,"lineage2","dr_mutations_pyrazinamide","ARG",0,"SRR6117320","SRR6117320","lineage2.2.1.1","au","","pnca_p.trp68arg","A","B","TRP","WA68","pnca_complex.pdb"
|
|
"W68R","L1","PZA","W","W68",68,"R",NA,"MDR","DM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",4.974,-0.576,-1.608,0.0790982,-1.263,-1.5,89,91,-1.146,9,9,45,0.157894736842105,"strand",-1.1,5.49,0.0020123616501365,132.405612244898,132.40553086776,132.608758225219,119.023328875182,-18,-32,0,0,-32,0,0,0,0,-2,0,-2,0,0,0,0,0,-1,0,-4,3,2,0,0,-2,-0.145896656534954,-0.415503875968992,0.00288092861981803,-0.215345268542199,-0.392670157068063,0.936842105263158,-0.943986820428336,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.124,"9:9","150/150","F:W",4.88586941655608,1.59295080619135e-06,1.01805765099734,4.79920701128237,28.2126225203342,2362.8544732838,2.12190639382976,4.03470202806197e-20,19.3941885333947,21.793565475171,5246.53379470447,1.03505008297772e-27,"lineage1","dr_mutations_pyrazinamide","ARG",0,"ERR2517086","ERR2517086","lineage1.2.2","gb","UK","pnca_p.trp68arg","A","B","TRP","WA68","pnca_complex.pdb"
|
|
"W68R","L2","PZA","W","W68",68,"R",1,"Pre-XDR","DM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",4.974,-0.576,-1.608,0.0790982,-1.263,-1.5,89,91,-1.146,9,9,45,0.157894736842105,"strand",-1.1,5.49,0.0020123616501365,132.405612244898,132.40553086776,132.608758225219,119.023328875182,-18,-32,0,0,-32,0,0,0,0,-2,0,-2,0,0,0,0,0,-1,0,-4,3,2,0,0,-2,-0.145896656534954,-0.415503875968992,0.00288092861981803,-0.215345268542199,-0.392670157068063,0.936842105263158,-0.943986820428336,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.124,"9:9","150/150","F:W",4.88586941655608,1.59295080619135e-06,1.01805765099734,4.79920701128237,28.2126225203342,2362.8544732838,2.12190639382976,4.03470202806197e-20,19.3941885333947,21.793565475171,5246.53379470447,1.03505008297772e-27,"lineage2","dr_mutations_pyrazinamide","ARG",0,"ERS458620,SAMEA2535218","ERR553217_ERR553218","lineage2.2.1","uz","Nukus","pnca_p.trp68arg","A","B","TRP","WA68","pnca_complex.pdb"
|
|
"W68R","L2","PZA","W","W68",68,"R",1,"MDR","DM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",4.974,-0.576,-1.608,0.0790982,-1.263,-1.5,89,91,-1.146,9,9,45,0.157894736842105,"strand",-1.1,5.49,0.0020123616501365,132.405612244898,132.40553086776,132.608758225219,119.023328875182,-18,-32,0,0,-32,0,0,0,0,-2,0,-2,0,0,0,0,0,-1,0,-4,3,2,0,0,-2,-0.145896656534954,-0.415503875968992,0.00288092861981803,-0.215345268542199,-0.392670157068063,0.936842105263158,-0.943986820428336,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.124,"9:9","150/150","F:W",4.88586941655608,1.59295080619135e-06,1.01805765099734,4.79920701128237,28.2126225203342,2362.8544732838,2.12190639382976,4.03470202806197e-20,19.3941885333947,21.793565475171,5246.53379470447,1.03505008297772e-27,"lineage2","dr_mutations_pyrazinamide","ARG",0,"14MT_13373","SRR5526360","lineage2.2.1.1","pg","","pnca_p.trp68arg","A","B","TRP","WA68","pnca_complex.pdb"
|
|
"W68R","L2","PZA","W","W68",68,"R",1,"MDR","DM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",4.974,-0.576,-1.608,0.0790982,-1.263,-1.5,89,91,-1.146,9,9,45,0.157894736842105,"strand",-1.1,5.49,0.0020123616501365,132.405612244898,132.40553086776,132.608758225219,119.023328875182,-18,-32,0,0,-32,0,0,0,0,-2,0,-2,0,0,0,0,0,-1,0,-4,3,2,0,0,-2,-0.145896656534954,-0.415503875968992,0.00288092861981803,-0.215345268542199,-0.392670157068063,0.936842105263158,-0.943986820428336,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.124,"9:9","150/150","F:W",4.88586941655608,1.59295080619135e-06,1.01805765099734,4.79920701128237,28.2126225203342,2362.8544732838,2.12190639382976,4.03470202806197e-20,19.3941885333947,21.793565475171,5246.53379470447,1.03505008297772e-27,"lineage2","dr_mutations_pyrazinamide","ARG",0,"ERS457038","ERR551016_ERR551015","lineage2.2.1","uz","Nukus","pnca_p.trp68arg","A","B","TRP","WA68","pnca_complex.pdb"
|
|
"W68R","L4","PZA","W","W68",68,"R",NA,"MDR","DM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",4.974,-0.576,-1.608,0.0790982,-1.263,-1.5,89,91,-1.146,9,9,45,0.157894736842105,"strand",-1.1,5.49,0.0020123616501365,132.405612244898,132.40553086776,132.608758225219,119.023328875182,-18,-32,0,0,-32,0,0,0,0,-2,0,-2,0,0,0,0,0,-1,0,-4,3,2,0,0,-2,-0.145896656534954,-0.415503875968992,0.00288092861981803,-0.215345268542199,-0.392670157068063,0.936842105263158,-0.943986820428336,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.124,"9:9","150/150","F:W",4.88586941655608,1.59295080619135e-06,1.01805765099734,4.79920701128237,28.2126225203342,2362.8544732838,2.12190639382976,4.03470202806197e-20,19.3941885333947,21.793565475171,5246.53379470447,1.03505008297772e-27,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERR2516582","ERR2516582","lineage4.8","nl","Netherlands","pnca_p.trp68arg","A","B","TRP","WA68","pnca_complex.pdb"
|
|
"W68R","L2","PZA","W","W68",68,"R",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",4.974,-0.576,-1.608,0.0790982,-1.263,-1.5,89,91,-1.146,9,9,45,0.157894736842105,"strand",-1.1,5.49,0.0020123616501365,132.405612244898,132.40553086776,132.608758225219,119.023328875182,-18,-32,0,0,-32,0,0,0,0,-2,0,-2,0,0,0,0,0,-1,0,-4,3,2,0,0,-2,-0.145896656534954,-0.415503875968992,0.00288092861981803,-0.215345268542199,-0.392670157068063,0.936842105263158,-0.943986820428336,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.124,"9:9","150/150","F:W",4.88586941655608,1.59295080619135e-06,1.01805765099734,4.79920701128237,28.2126225203342,2362.8544732838,2.12190639382976,4.03470202806197e-20,19.3941885333947,21.793565475171,5246.53379470447,1.03505008297772e-27,"lineage2","dr_mutations_pyrazinamide","ARG",0,"SAMN02419577","SRR1162526_SRR1158989_SRR1181309_SRR1181074","lineage2.2.1","by","Belarus","pnca_p.trp68arg","A","B","TRP","WA68","pnca_complex.pdb"
|
|
"W68R","L2","PZA","W","W68",68,"R",NA,"Pre-MDR","DM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",4.974,-0.576,-1.608,0.0790982,-1.263,-1.5,89,91,-1.146,9,9,45,0.157894736842105,"strand",-1.1,5.49,0.0020123616501365,132.405612244898,132.40553086776,132.608758225219,119.023328875182,-18,-32,0,0,-32,0,0,0,0,-2,0,-2,0,0,0,0,0,-1,0,-4,3,2,0,0,-2,-0.145896656534954,-0.415503875968992,0.00288092861981803,-0.215345268542199,-0.392670157068063,0.936842105263158,-0.943986820428336,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.124,"9:9","150/150","F:W",4.88586941655608,1.59295080619135e-06,1.01805765099734,4.79920701128237,28.2126225203342,2362.8544732838,2.12190639382976,4.03470202806197e-20,19.3941885333947,21.793565475171,5246.53379470447,1.03505008297772e-27,"lineage2","dr_mutations_pyrazinamide","ARG",0,"SAMN07236517,SRR5709902","SRR5709902","lineage2.2.1","th","Thailand","pnca_p.trp68arg","A","B","TRP","WA68","pnca_complex.pdb"
|
|
"W68R","L2","PZA","W","W68",68,"R",1,"MDR","DM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",4.974,-0.576,-1.608,0.0790982,-1.263,-1.5,89,91,-1.146,9,9,45,0.157894736842105,"strand",-1.1,5.49,0.0020123616501365,132.405612244898,132.40553086776,132.608758225219,119.023328875182,-18,-32,0,0,-32,0,0,0,0,-2,0,-2,0,0,0,0,0,-1,0,-4,3,2,0,0,-2,-0.145896656534954,-0.415503875968992,0.00288092861981803,-0.215345268542199,-0.392670157068063,0.936842105263158,-0.943986820428336,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.124,"9:9","150/150","F:W",4.88586941655608,1.59295080619135e-06,1.01805765099734,4.79920701128237,28.2126225203342,2362.8544732838,2.12190639382976,4.03470202806197e-20,19.3941885333947,21.793565475171,5246.53379470447,1.03505008297772e-27,"lineage2","dr_mutations_pyrazinamide","ARG",0,"14MT_9914","SRR5527200","lineage2.2.1.1","pg","","pnca_p.trp68arg","A","B","TRP","WA68","pnca_complex.pdb"
|
|
"W68R","L2","PZA","W","W68",68,"R",1,"Pre-XDR","DM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",4.974,-0.576,-1.608,0.0790982,-1.263,-1.5,89,91,-1.146,9,9,45,0.157894736842105,"strand",-1.1,5.49,0.0020123616501365,132.405612244898,132.40553086776,132.608758225219,119.023328875182,-18,-32,0,0,-32,0,0,0,0,-2,0,-2,0,0,0,0,0,-1,0,-4,3,2,0,0,-2,-0.145896656534954,-0.415503875968992,0.00288092861981803,-0.215345268542199,-0.392670157068063,0.936842105263158,-0.943986820428336,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.124,"9:9","150/150","F:W",4.88586941655608,1.59295080619135e-06,1.01805765099734,4.79920701128237,28.2126225203342,2362.8544732838,2.12190639382976,4.03470202806197e-20,19.3941885333947,21.793565475171,5246.53379470447,1.03505008297772e-27,"lineage2","dr_mutations_pyrazinamide","ARG",0,"1461P-sc-2012-10-11T13:37:22Z-1494137,ERR234651","ERR234651","lineage2.2.1","ru","Russia","pnca_p.trp68arg","A","B","TRP","WA68","pnca_complex.pdb"
|
|
"W68R","L2","PZA","W","W68",68,"R",NA,"MDR","DM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",4.974,-0.576,-1.608,0.0790982,-1.263,-1.5,89,91,-1.146,9,9,45,0.157894736842105,"strand",-1.1,5.49,0.0020123616501365,132.405612244898,132.40553086776,132.608758225219,119.023328875182,-18,-32,0,0,-32,0,0,0,0,-2,0,-2,0,0,0,0,0,-1,0,-4,3,2,0,0,-2,-0.145896656534954,-0.415503875968992,0.00288092861981803,-0.215345268542199,-0.392670157068063,0.936842105263158,-0.943986820428336,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.124,"9:9","150/150","F:W",4.88586941655608,1.59295080619135e-06,1.01805765099734,4.79920701128237,28.2126225203342,2362.8544732838,2.12190639382976,4.03470202806197e-20,19.3941885333947,21.793565475171,5246.53379470447,1.03505008297772e-27,"lineage2","dr_mutations_pyrazinamide","ARG",0,"SRR6040100","SRR6040100","lineage2.2.1.1","au","","pnca_p.trp68arg","A","B","TRP","WA68","pnca_complex.pdb"
|
|
"W68R","L2","PZA","W","W68",68,"R",1,"MDR","DM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",4.974,-0.576,-1.608,0.0790982,-1.263,-1.5,89,91,-1.146,9,9,45,0.157894736842105,"strand",-1.1,5.49,0.0020123616501365,132.405612244898,132.40553086776,132.608758225219,119.023328875182,-18,-32,0,0,-32,0,0,0,0,-2,0,-2,0,0,0,0,0,-1,0,-4,3,2,0,0,-2,-0.145896656534954,-0.415503875968992,0.00288092861981803,-0.215345268542199,-0.392670157068063,0.936842105263158,-0.943986820428336,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.124,"9:9","150/150","F:W",4.88586941655608,1.59295080619135e-06,1.01805765099734,4.79920701128237,28.2126225203342,2362.8544732838,2.12190639382976,4.03470202806197e-20,19.3941885333947,21.793565475171,5246.53379470447,1.03505008297772e-27,"lineage2","dr_mutations_pyrazinamide","ARG",0,"14MT_17284","SRR5526839","lineage2.2.1.1","pg","","pnca_p.trp68arg","A","B","TRP","WA68","pnca_complex.pdb"
|
|
"W68R","L2","PZA","W","W68",68,"R",1,"XDR","DM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",4.974,-0.576,-1.608,0.0790982,-1.263,-1.5,89,91,-1.146,9,9,45,0.157894736842105,"strand",-1.1,5.49,0.0020123616501365,132.405612244898,132.40553086776,132.608758225219,119.023328875182,-18,-32,0,0,-32,0,0,0,0,-2,0,-2,0,0,0,0,0,-1,0,-4,3,2,0,0,-2,-0.145896656534954,-0.415503875968992,0.00288092861981803,-0.215345268542199,-0.392670157068063,0.936842105263158,-0.943986820428336,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.124,"9:9","150/150","F:W",4.88586941655608,1.59295080619135e-06,1.01805765099734,4.79920701128237,28.2126225203342,2362.8544732838,2.12190639382976,4.03470202806197e-20,19.3941885333947,21.793565475171,5246.53379470447,1.03505008297772e-27,"lineage2","dr_mutations_pyrazinamide","ARG",0,"14MT_2684","SRR5526865","lineage2.2.1.1","pg","","pnca_p.trp68arg","A","B","TRP","WA68","pnca_complex.pdb"
|
|
"W68R","L2","PZA","W","W68",68,"R",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",4.974,-0.576,-1.608,0.0790982,-1.263,-1.5,89,91,-1.146,9,9,45,0.157894736842105,"strand",-1.1,5.49,0.0020123616501365,132.405612244898,132.40553086776,132.608758225219,119.023328875182,-18,-32,0,0,-32,0,0,0,0,-2,0,-2,0,0,0,0,0,-1,0,-4,3,2,0,0,-2,-0.145896656534954,-0.415503875968992,0.00288092861981803,-0.215345268542199,-0.392670157068063,0.936842105263158,-0.943986820428336,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.124,"9:9","150/150","F:W",4.88586941655608,1.59295080619135e-06,1.01805765099734,4.79920701128237,28.2126225203342,2362.8544732838,2.12190639382976,4.03470202806197e-20,19.3941885333947,21.793565475171,5246.53379470447,1.03505008297772e-27,"lineage2","dr_mutations_pyrazinamide","ARG",0,"ERR234621","ERR234621","lineage2.2.1","ru","Russia","pnca_p.trp68arg","A","B","TRP","WA68","pnca_complex.pdb"
|
|
"W68R","L4","PZA","W","W68",68,"R",NA,"MDR","DM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",4.974,-0.576,-1.608,0.0790982,-1.263,-1.5,89,91,-1.146,9,9,45,0.157894736842105,"strand",-1.1,5.49,0.0020123616501365,132.405612244898,132.40553086776,132.608758225219,119.023328875182,-18,-32,0,0,-32,0,0,0,0,-2,0,-2,0,0,0,0,0,-1,0,-4,3,2,0,0,-2,-0.145896656534954,-0.415503875968992,0.00288092861981803,-0.215345268542199,-0.392670157068063,0.936842105263158,-0.943986820428336,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.124,"9:9","150/150","F:W",4.88586941655608,1.59295080619135e-06,1.01805765099734,4.79920701128237,28.2126225203342,2362.8544732838,2.12190639382976,4.03470202806197e-20,19.3941885333947,21.793565475171,5246.53379470447,1.03505008297772e-27,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERR1465875","ERR1465875","lineage4.8","","unknown","pnca_p.trp68arg","A","B","TRP","WA68","pnca_complex.pdb"
|
|
"W68R","L4","PZA","W","W68",68,"R",NA,"MDR","DM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",4.974,-0.576,-1.608,0.0790982,-1.263,-1.5,89,91,-1.146,9,9,45,0.157894736842105,"strand",-1.1,5.49,0.0020123616501365,132.405612244898,132.40553086776,132.608758225219,119.023328875182,-18,-32,0,0,-32,0,0,0,0,-2,0,-2,0,0,0,0,0,-1,0,-4,3,2,0,0,-2,-0.145896656534954,-0.415503875968992,0.00288092861981803,-0.215345268542199,-0.392670157068063,0.936842105263158,-0.943986820428336,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.124,"9:9","150/150","F:W",4.88586941655608,1.59295080619135e-06,1.01805765099734,4.79920701128237,28.2126225203342,2362.8544732838,2.12190639382976,4.03470202806197e-20,19.3941885333947,21.793565475171,5246.53379470447,1.03505008297772e-27,"lineage4","dr_mutations_pyrazinamide","ARG",0,"SAMN02585996","SRR1196552_SRR1184325_SRR1172865_SRR1175092","lineage4.3.2.1","za","South Africa","pnca_p.trp68arg","A","B","TRP","WA68","pnca_complex.pdb"
|
|
"W68R","L2","PZA","W","W68",68,"R",1,"MDR","DM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",4.974,-0.576,-1.608,0.0790982,-1.263,-1.5,89,91,-1.146,9,9,45,0.157894736842105,"strand",-1.1,5.49,0.0020123616501365,132.405612244898,132.40553086776,132.608758225219,119.023328875182,-18,-32,0,0,-32,0,0,0,0,-2,0,-2,0,0,0,0,0,-1,0,-4,3,2,0,0,-2,-0.145896656534954,-0.415503875968992,0.00288092861981803,-0.215345268542199,-0.392670157068063,0.936842105263158,-0.943986820428336,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.124,"9:9","150/150","F:W",4.88586941655608,1.59295080619135e-06,1.01805765099734,4.79920701128237,28.2126225203342,2362.8544732838,2.12190639382976,4.03470202806197e-20,19.3941885333947,21.793565475171,5246.53379470447,1.03505008297772e-27,"lineage2","dr_mutations_pyrazinamide","ARG",0,"14MT_11629","SRR5525997","lineage2.2.1.1","pg","","pnca_p.trp68arg","A","B","TRP","WA68","pnca_complex.pdb"
|
|
"W68R","L2","PZA","W","W68",68,"R",NA,"MDR","DM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",4.974,-0.576,-1.608,0.0790982,-1.263,-1.5,89,91,-1.146,9,9,45,0.157894736842105,"strand",-1.1,5.49,0.0020123616501365,132.405612244898,132.40553086776,132.608758225219,119.023328875182,-18,-32,0,0,-32,0,0,0,0,-2,0,-2,0,0,0,0,0,-1,0,-4,3,2,0,0,-2,-0.145896656534954,-0.415503875968992,0.00288092861981803,-0.215345268542199,-0.392670157068063,0.936842105263158,-0.943986820428336,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.124,"9:9","150/150","F:W",4.88586941655608,1.59295080619135e-06,1.01805765099734,4.79920701128237,28.2126225203342,2362.8544732838,2.12190639382976,4.03470202806197e-20,19.3941885333947,21.793565475171,5246.53379470447,1.03505008297772e-27,"lineage2","dr_mutations_pyrazinamide","ARG",0,"SRR6117345","SRR6117345","lineage2.2.1.1","au","","pnca_p.trp68arg","A","B","TRP","WA68","pnca_complex.pdb"
|
|
"W68R","L2","PZA","W","W68",68,"R",1,"MDR","DM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",4.974,-0.576,-1.608,0.0790982,-1.263,-1.5,89,91,-1.146,9,9,45,0.157894736842105,"strand",-1.1,5.49,0.0020123616501365,132.405612244898,132.40553086776,132.608758225219,119.023328875182,-18,-32,0,0,-32,0,0,0,0,-2,0,-2,0,0,0,0,0,-1,0,-4,3,2,0,0,-2,-0.145896656534954,-0.415503875968992,0.00288092861981803,-0.215345268542199,-0.392670157068063,0.936842105263158,-0.943986820428336,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.124,"9:9","150/150","F:W",4.88586941655608,1.59295080619135e-06,1.01805765099734,4.79920701128237,28.2126225203342,2362.8544732838,2.12190639382976,4.03470202806197e-20,19.3941885333947,21.793565475171,5246.53379470447,1.03505008297772e-27,"lineage2","dr_mutations_pyrazinamide","ARG",0,"15MT_4695","SRR5552415","lineage2.2.1.1","pg","","pnca_p.trp68arg","A","B","TRP","WA68","pnca_complex.pdb"
|
|
"W68R","L3","PZA","W","W68",68,"R",NA,"MDR","DM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",4.974,-0.576,-1.608,0.0790982,-1.263,-1.5,89,91,-1.146,9,9,45,0.157894736842105,"strand",-1.1,5.49,0.0020123616501365,132.405612244898,132.40553086776,132.608758225219,119.023328875182,-18,-32,0,0,-32,0,0,0,0,-2,0,-2,0,0,0,0,0,-1,0,-4,3,2,0,0,-2,-0.145896656534954,-0.415503875968992,0.00288092861981803,-0.215345268542199,-0.392670157068063,0.936842105263158,-0.943986820428336,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.124,"9:9","150/150","F:W",4.88586941655608,1.59295080619135e-06,1.01805765099734,4.79920701128237,28.2126225203342,2362.8544732838,2.12190639382976,4.03470202806197e-20,19.3941885333947,21.793565475171,5246.53379470447,1.03505008297772e-27,"lineage3","dr_mutations_pyrazinamide","ARG",0,"SAMN02414913","SRR1163382_SRR1163175_SRR1146375_SRR1144740","lineage3","se","Sweden","pnca_p.trp68arg","A","B","TRP","WA68","pnca_complex.pdb"
|
|
"W68R","L2","PZA","W","W68",68,"R",NA,"MDR","DM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",4.974,-0.576,-1.608,0.0790982,-1.263,-1.5,89,91,-1.146,9,9,45,0.157894736842105,"strand",-1.1,5.49,0.0020123616501365,132.405612244898,132.40553086776,132.608758225219,119.023328875182,-18,-32,0,0,-32,0,0,0,0,-2,0,-2,0,0,0,0,0,-1,0,-4,3,2,0,0,-2,-0.145896656534954,-0.415503875968992,0.00288092861981803,-0.215345268542199,-0.392670157068063,0.936842105263158,-0.943986820428336,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.124,"9:9","150/150","F:W",4.88586941655608,1.59295080619135e-06,1.01805765099734,4.79920701128237,28.2126225203342,2362.8544732838,2.12190639382976,4.03470202806197e-20,19.3941885333947,21.793565475171,5246.53379470447,1.03505008297772e-27,"lineage2","dr_mutations_pyrazinamide","ARG",0,"SRR6079922","SRR6079922","lineage2.2.1.1","au","","pnca_p.trp68arg","A","B","TRP","WA68","pnca_complex.pdb"
|
|
"W68R","L2","PZA","W","W68",68,"R",1,"MDR","DM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",4.974,-0.576,-1.608,0.0790982,-1.263,-1.5,89,91,-1.146,9,9,45,0.157894736842105,"strand",-1.1,5.49,0.0020123616501365,132.405612244898,132.40553086776,132.608758225219,119.023328875182,-18,-32,0,0,-32,0,0,0,0,-2,0,-2,0,0,0,0,0,-1,0,-4,3,2,0,0,-2,-0.145896656534954,-0.415503875968992,0.00288092861981803,-0.215345268542199,-0.392670157068063,0.936842105263158,-0.943986820428336,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.124,"9:9","150/150","F:W",4.88586941655608,1.59295080619135e-06,1.01805765099734,4.79920701128237,28.2126225203342,2362.8544732838,2.12190639382976,4.03470202806197e-20,19.3941885333947,21.793565475171,5246.53379470447,1.03505008297772e-27,"lineage2","dr_mutations_pyrazinamide","ARG",0,"ERR552954","ERR552954","lineage2.2.1","de","Germany","pnca_p.trp68arg","A","B","TRP","WA68","pnca_complex.pdb"
|
|
"W68R","L1","PZA","W","W68",68,"R",1,"MDR","DM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",4.974,-0.576,-1.608,0.0790982,-1.263,-1.5,89,91,-1.146,9,9,45,0.157894736842105,"strand",-1.1,5.49,0.0020123616501365,132.405612244898,132.40553086776,132.608758225219,119.023328875182,-18,-32,0,0,-32,0,0,0,0,-2,0,-2,0,0,0,0,0,-1,0,-4,3,2,0,0,-2,-0.145896656534954,-0.415503875968992,0.00288092861981803,-0.215345268542199,-0.392670157068063,0.936842105263158,-0.943986820428336,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.124,"9:9","150/150","F:W",4.88586941655608,1.59295080619135e-06,1.01805765099734,4.79920701128237,28.2126225203342,2362.8544732838,2.12190639382976,4.03470202806197e-20,19.3941885333947,21.793565475171,5246.53379470447,1.03505008297772e-27,"lineage1","dr_mutations_pyrazinamide","ARG",0,"ERR2516802","ERR2516802","lineage1.2.2","gb","UK","pnca_p.trp68arg","A","B","TRP","WA68","pnca_complex.pdb"
|
|
"W68R","L2","PZA","W","W68",68,"R",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",4.974,-0.576,-1.608,0.0790982,-1.263,-1.5,89,91,-1.146,9,9,45,0.157894736842105,"strand",-1.1,5.49,0.0020123616501365,132.405612244898,132.40553086776,132.608758225219,119.023328875182,-18,-32,0,0,-32,0,0,0,0,-2,0,-2,0,0,0,0,0,-1,0,-4,3,2,0,0,-2,-0.145896656534954,-0.415503875968992,0.00288092861981803,-0.215345268542199,-0.392670157068063,0.936842105263158,-0.943986820428336,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.124,"9:9","150/150","F:W",4.88586941655608,1.59295080619135e-06,1.01805765099734,4.79920701128237,28.2126225203342,2362.8544732838,2.12190639382976,4.03470202806197e-20,19.3941885333947,21.793565475171,5246.53379470447,1.03505008297772e-27,"lineage2","dr_mutations_pyrazinamide","ARG",0,"SAMN02419592","SRR1162509_SRR1180990_SRR1158943_SRR1184127","lineage2.2.1","by","Belarus","pnca_p.trp68arg","A","B","TRP","WA68","pnca_complex.pdb"
|
|
"W68R","L2","PZA","W","W68",68,"R",NA,"MDR","DM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",4.974,-0.576,-1.608,0.0790982,-1.263,-1.5,89,91,-1.146,9,9,45,0.157894736842105,"strand",-1.1,5.49,0.0020123616501365,132.405612244898,132.40553086776,132.608758225219,119.023328875182,-18,-32,0,0,-32,0,0,0,0,-2,0,-2,0,0,0,0,0,-1,0,-4,3,2,0,0,-2,-0.145896656534954,-0.415503875968992,0.00288092861981803,-0.215345268542199,-0.392670157068063,0.936842105263158,-0.943986820428336,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.124,"9:9","150/150","F:W",4.88586941655608,1.59295080619135e-06,1.01805765099734,4.79920701128237,28.2126225203342,2362.8544732838,2.12190639382976,4.03470202806197e-20,19.3941885333947,21.793565475171,5246.53379470447,1.03505008297772e-27,"lineage2","dr_mutations_pyrazinamide","ARG",0,"SRR6079967","SRR6079967","lineage2.2.1.1","au","","pnca_p.trp68arg","A","B","TRP","WA68","pnca_complex.pdb"
|
|
"W68R","L2","PZA","W","W68",68,"R",NA,"MDR","DM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",4.974,-0.576,-1.608,0.0790982,-1.263,-1.5,89,91,-1.146,9,9,45,0.157894736842105,"strand",-1.1,5.49,0.0020123616501365,132.405612244898,132.40553086776,132.608758225219,119.023328875182,-18,-32,0,0,-32,0,0,0,0,-2,0,-2,0,0,0,0,0,-1,0,-4,3,2,0,0,-2,-0.145896656534954,-0.415503875968992,0.00288092861981803,-0.215345268542199,-0.392670157068063,0.936842105263158,-0.943986820428336,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.124,"9:9","150/150","F:W",4.88586941655608,1.59295080619135e-06,1.01805765099734,4.79920701128237,28.2126225203342,2362.8544732838,2.12190639382976,4.03470202806197e-20,19.3941885333947,21.793565475171,5246.53379470447,1.03505008297772e-27,"lineage2","dr_mutations_pyrazinamide","ARG",0,"SRR6079930","SRR6079930","lineage2.2.1.1","au","","pnca_p.trp68arg","A","B","TRP","WA68","pnca_complex.pdb"
|
|
"W68R","L2","PZA","W","W68",68,"R",1,"MDR","DM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",4.974,-0.576,-1.608,0.0790982,-1.263,-1.5,89,91,-1.146,9,9,45,0.157894736842105,"strand",-1.1,5.49,0.0020123616501365,132.405612244898,132.40553086776,132.608758225219,119.023328875182,-18,-32,0,0,-32,0,0,0,0,-2,0,-2,0,0,0,0,0,-1,0,-4,3,2,0,0,-2,-0.145896656534954,-0.415503875968992,0.00288092861981803,-0.215345268542199,-0.392670157068063,0.936842105263158,-0.943986820428336,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.124,"9:9","150/150","F:W",4.88586941655608,1.59295080619135e-06,1.01805765099734,4.79920701128237,28.2126225203342,2362.8544732838,2.12190639382976,4.03470202806197e-20,19.3941885333947,21.793565475171,5246.53379470447,1.03505008297772e-27,"lineage2","dr_mutations_pyrazinamide","ARG",0,"14MT_13364","SRR5526157","lineage2.2.1.1","pg","","pnca_p.trp68arg","A","B","TRP","WA68","pnca_complex.pdb"
|
|
"W68R","L2","PZA","W","W68",68,"R",1,"MDR","DM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",4.974,-0.576,-1.608,0.0790982,-1.263,-1.5,89,91,-1.146,9,9,45,0.157894736842105,"strand",-1.1,5.49,0.0020123616501365,132.405612244898,132.40553086776,132.608758225219,119.023328875182,-18,-32,0,0,-32,0,0,0,0,-2,0,-2,0,0,0,0,0,-1,0,-4,3,2,0,0,-2,-0.145896656534954,-0.415503875968992,0.00288092861981803,-0.215345268542199,-0.392670157068063,0.936842105263158,-0.943986820428336,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.124,"9:9","150/150","F:W",4.88586941655608,1.59295080619135e-06,1.01805765099734,4.79920701128237,28.2126225203342,2362.8544732838,2.12190639382976,4.03470202806197e-20,19.3941885333947,21.793565475171,5246.53379470447,1.03505008297772e-27,"lineage2","dr_mutations_pyrazinamide","ARG",0,"14MT_20601","SRR5526842","lineage2.2.1.1","pg","","pnca_p.trp68arg","A","B","TRP","WA68","pnca_complex.pdb"
|
|
"W68R","L4","PZA","W","W68",68,"R",1,"MDR","DM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",4.974,-0.576,-1.608,0.0790982,-1.263,-1.5,89,91,-1.146,9,9,45,0.157894736842105,"strand",-1.1,5.49,0.0020123616501365,132.405612244898,132.40553086776,132.608758225219,119.023328875182,-18,-32,0,0,-32,0,0,0,0,-2,0,-2,0,0,0,0,0,-1,0,-4,3,2,0,0,-2,-0.145896656534954,-0.415503875968992,0.00288092861981803,-0.215345268542199,-0.392670157068063,0.936842105263158,-0.943986820428336,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.124,"9:9","150/150","F:W",4.88586941655608,1.59295080619135e-06,1.01805765099734,4.79920701128237,28.2126225203342,2362.8544732838,2.12190639382976,4.03470202806197e-20,19.3941885333947,21.793565475171,5246.53379470447,1.03505008297772e-27,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERR2516732","ERR2516732","lineage4.3.2","pe","Peru","pnca_p.trp68arg","A","B","TRP","WA68","pnca_complex.pdb"
|
|
"W68R","L4","PZA","W","W68",68,"R",NA,"MDR","DM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",4.974,-0.576,-1.608,0.0790982,-1.263,-1.5,89,91,-1.146,9,9,45,0.157894736842105,"strand",-1.1,5.49,0.0020123616501365,132.405612244898,132.40553086776,132.608758225219,119.023328875182,-18,-32,0,0,-32,0,0,0,0,-2,0,-2,0,0,0,0,0,-1,0,-4,3,2,0,0,-2,-0.145896656534954,-0.415503875968992,0.00288092861981803,-0.215345268542199,-0.392670157068063,0.936842105263158,-0.943986820428336,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.124,"9:9","150/150","F:W",4.88586941655608,1.59295080619135e-06,1.01805765099734,4.79920701128237,28.2126225203342,2362.8544732838,2.12190639382976,4.03470202806197e-20,19.3941885333947,21.793565475171,5246.53379470447,1.03505008297772e-27,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERR3256126","ERR3256126","lineage4.3.4.2","ph","Philippines","pnca_p.trp68arg","A","B","TRP","WA68","pnca_complex.pdb"
|
|
"W68R","L2","PZA","W","W68",68,"R",1,"MDR","DM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",4.974,-0.576,-1.608,0.0790982,-1.263,-1.5,89,91,-1.146,9,9,45,0.157894736842105,"strand",-1.1,5.49,0.0020123616501365,132.405612244898,132.40553086776,132.608758225219,119.023328875182,-18,-32,0,0,-32,0,0,0,0,-2,0,-2,0,0,0,0,0,-1,0,-4,3,2,0,0,-2,-0.145896656534954,-0.415503875968992,0.00288092861981803,-0.215345268542199,-0.392670157068063,0.936842105263158,-0.943986820428336,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.124,"9:9","150/150","F:W",4.88586941655608,1.59295080619135e-06,1.01805765099734,4.79920701128237,28.2126225203342,2362.8544732838,2.12190639382976,4.03470202806197e-20,19.3941885333947,21.793565475171,5246.53379470447,1.03505008297772e-27,"lineage2","dr_mutations_pyrazinamide","ARG",0,"14MT_9929","SRR5533131","lineage2.2.1.1","pg","","pnca_p.trp68arg","A","B","TRP","WA68","pnca_complex.pdb"
|
|
"W68R","L2","PZA","W","W68",68,"R",1,"MDR","DM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",4.974,-0.576,-1.608,0.0790982,-1.263,-1.5,89,91,-1.146,9,9,45,0.157894736842105,"strand",-1.1,5.49,0.0020123616501365,132.405612244898,132.40553086776,132.608758225219,119.023328875182,-18,-32,0,0,-32,0,0,0,0,-2,0,-2,0,0,0,0,0,-1,0,-4,3,2,0,0,-2,-0.145896656534954,-0.415503875968992,0.00288092861981803,-0.215345268542199,-0.392670157068063,0.936842105263158,-0.943986820428336,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.124,"9:9","150/150","F:W",4.88586941655608,1.59295080619135e-06,1.01805765099734,4.79920701128237,28.2126225203342,2362.8544732838,2.12190639382976,4.03470202806197e-20,19.3941885333947,21.793565475171,5246.53379470447,1.03505008297772e-27,"lineage2","dr_mutations_pyrazinamide","ARG",0,"14MT_6103","SRR5526903","lineage2.2.1.1","pg","","pnca_p.trp68arg","A","B","TRP","WA68","pnca_complex.pdb"
|
|
"W68R","L2","PZA","W","W68",68,"R",NA,"MDR","DM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",4.974,-0.576,-1.608,0.0790982,-1.263,-1.5,89,91,-1.146,9,9,45,0.157894736842105,"strand",-1.1,5.49,0.0020123616501365,132.405612244898,132.40553086776,132.608758225219,119.023328875182,-18,-32,0,0,-32,0,0,0,0,-2,0,-2,0,0,0,0,0,-1,0,-4,3,2,0,0,-2,-0.145896656534954,-0.415503875968992,0.00288092861981803,-0.215345268542199,-0.392670157068063,0.936842105263158,-0.943986820428336,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.124,"9:9","150/150","F:W",4.88586941655608,1.59295080619135e-06,1.01805765099734,4.79920701128237,28.2126225203342,2362.8544732838,2.12190639382976,4.03470202806197e-20,19.3941885333947,21.793565475171,5246.53379470447,1.03505008297772e-27,"lineage2","dr_mutations_pyrazinamide","ARG",0,"SRR5065250","SRR5065250","lineage2.2.1","vn","Vietnam","pnca_p.trp68arg","A","B","TRP","WA68","pnca_complex.pdb"
|
|
"W68R","L2","PZA","W","W68",68,"R",1,"Pre-XDR","DM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",4.974,-0.576,-1.608,0.0790982,-1.263,-1.5,89,91,-1.146,9,9,45,0.157894736842105,"strand",-1.1,5.49,0.0020123616501365,132.405612244898,132.40553086776,132.608758225219,119.023328875182,-18,-32,0,0,-32,0,0,0,0,-2,0,-2,0,0,0,0,0,-1,0,-4,3,2,0,0,-2,-0.145896656534954,-0.415503875968992,0.00288092861981803,-0.215345268542199,-0.392670157068063,0.936842105263158,-0.943986820428336,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.124,"9:9","150/150","F:W",4.88586941655608,1.59295080619135e-06,1.01805765099734,4.79920701128237,28.2126225203342,2362.8544732838,2.12190639382976,4.03470202806197e-20,19.3941885333947,21.793565475171,5246.53379470447,1.03505008297772e-27,"lineage2","dr_mutations_pyrazinamide","ARG",0,"SAMEA2533458,ERS456860","ERR550770_ERR550771","lineage2.2.1","uz","Nukus","pnca_p.trp68arg","A","B","TRP","WA68","pnca_complex.pdb"
|
|
"W68R","L2","PZA","W","W68",68,"R",NA,"Pre-MDR","DM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",4.974,-0.576,-1.608,0.0790982,-1.263,-1.5,89,91,-1.146,9,9,45,0.157894736842105,"strand",-1.1,5.49,0.0020123616501365,132.405612244898,132.40553086776,132.608758225219,119.023328875182,-18,-32,0,0,-32,0,0,0,0,-2,0,-2,0,0,0,0,0,-1,0,-4,3,2,0,0,-2,-0.145896656534954,-0.415503875968992,0.00288092861981803,-0.215345268542199,-0.392670157068063,0.936842105263158,-0.943986820428336,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.124,"9:9","150/150","F:W",4.88586941655608,1.59295080619135e-06,1.01805765099734,4.79920701128237,28.2126225203342,2362.8544732838,2.12190639382976,4.03470202806197e-20,19.3941885333947,21.793565475171,5246.53379470447,1.03505008297772e-27,"lineage2","dr_mutations_pyrazinamide","ARG",0,"ERR502936","ERR502936","lineage2.2.1","","","pnca_p.trp68arg","A","B","TRP","WA68","pnca_complex.pdb"
|
|
"W68R","L1","PZA","W","W68",68,"R",NA,"XDR","DM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",4.974,-0.576,-1.608,0.0790982,-1.263,-1.5,89,91,-1.146,9,9,45,0.157894736842105,"strand",-1.1,5.49,0.0020123616501365,132.405612244898,132.40553086776,132.608758225219,119.023328875182,-18,-32,0,0,-32,0,0,0,0,-2,0,-2,0,0,0,0,0,-1,0,-4,3,2,0,0,-2,-0.145896656534954,-0.415503875968992,0.00288092861981803,-0.215345268542199,-0.392670157068063,0.936842105263158,-0.943986820428336,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.124,"9:9","150/150","F:W",4.88586941655608,1.59295080619135e-06,1.01805765099734,4.79920701128237,28.2126225203342,2362.8544732838,2.12190639382976,4.03470202806197e-20,19.3941885333947,21.793565475171,5246.53379470447,1.03505008297772e-27,"lineage1","dr_mutations_pyrazinamide","ARG",0,"ERR1035096","ERR1035096","lineage1.1.1.1","vn","Vietnam","pnca_p.trp68arg","A","B","TRP","WA68","pnca_complex.pdb"
|
|
"W68R","L2","PZA","W","W68",68,"R",NA,"Pre-MDR","DM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",4.974,-0.576,-1.608,0.0790982,-1.263,-1.5,89,91,-1.146,9,9,45,0.157894736842105,"strand",-1.1,5.49,0.0020123616501365,132.405612244898,132.40553086776,132.608758225219,119.023328875182,-18,-32,0,0,-32,0,0,0,0,-2,0,-2,0,0,0,0,0,-1,0,-4,3,2,0,0,-2,-0.145896656534954,-0.415503875968992,0.00288092861981803,-0.215345268542199,-0.392670157068063,0.936842105263158,-0.943986820428336,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.124,"9:9","150/150","F:W",4.88586941655608,1.59295080619135e-06,1.01805765099734,4.79920701128237,28.2126225203342,2362.8544732838,2.12190639382976,4.03470202806197e-20,19.3941885333947,21.793565475171,5246.53379470447,1.03505008297772e-27,"lineage2","dr_mutations_pyrazinamide","ARG",0,"SAMN07236296,SRR5709870","SRR5709870","lineage2.2.1","th","Thailand","pnca_p.trp68arg","A","B","TRP","WA68","pnca_complex.pdb"
|
|
"W68R","L2","PZA","W","W68",68,"R",1,"MDR","DM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",4.974,-0.576,-1.608,0.0790982,-1.263,-1.5,89,91,-1.146,9,9,45,0.157894736842105,"strand",-1.1,5.49,0.0020123616501365,132.405612244898,132.40553086776,132.608758225219,119.023328875182,-18,-32,0,0,-32,0,0,0,0,-2,0,-2,0,0,0,0,0,-1,0,-4,3,2,0,0,-2,-0.145896656534954,-0.415503875968992,0.00288092861981803,-0.215345268542199,-0.392670157068063,0.936842105263158,-0.943986820428336,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.124,"9:9","150/150","F:W",4.88586941655608,1.59295080619135e-06,1.01805765099734,4.79920701128237,28.2126225203342,2362.8544732838,2.12190639382976,4.03470202806197e-20,19.3941885333947,21.793565475171,5246.53379470447,1.03505008297772e-27,"lineage2","dr_mutations_pyrazinamide","ARG",0,"15MT_1232","SRR5549699","lineage2.2.1.1","pg","","pnca_p.trp68arg","A","B","TRP","WA68","pnca_complex.pdb"
|
|
"W68R","L2","PZA","W","W68",68,"R",NA,"MDR","DM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",4.974,-0.576,-1.608,0.0790982,-1.263,-1.5,89,91,-1.146,9,9,45,0.157894736842105,"strand",-1.1,5.49,0.0020123616501365,132.405612244898,132.40553086776,132.608758225219,119.023328875182,-18,-32,0,0,-32,0,0,0,0,-2,0,-2,0,0,0,0,0,-1,0,-4,3,2,0,0,-2,-0.145896656534954,-0.415503875968992,0.00288092861981803,-0.215345268542199,-0.392670157068063,0.936842105263158,-0.943986820428336,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.124,"9:9","150/150","F:W",4.88586941655608,1.59295080619135e-06,1.01805765099734,4.79920701128237,28.2126225203342,2362.8544732838,2.12190639382976,4.03470202806197e-20,19.3941885333947,21.793565475171,5246.53379470447,1.03505008297772e-27,"lineage2","dr_mutations_pyrazinamide","ARG",0,"SAMN03653242,SRS935992","SRR2024938","lineage2.2.1","cn","China","pnca_p.trp68arg","A","B","TRP","WA68","pnca_complex.pdb"
|
|
"W68R","L2","PZA","W","W68",68,"R",1,"MDR","DM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",4.974,-0.576,-1.608,0.0790982,-1.263,-1.5,89,91,-1.146,9,9,45,0.157894736842105,"strand",-1.1,5.49,0.0020123616501365,132.405612244898,132.40553086776,132.608758225219,119.023328875182,-18,-32,0,0,-32,0,0,0,0,-2,0,-2,0,0,0,0,0,-1,0,-4,3,2,0,0,-2,-0.145896656534954,-0.415503875968992,0.00288092861981803,-0.215345268542199,-0.392670157068063,0.936842105263158,-0.943986820428336,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.124,"9:9","150/150","F:W",4.88586941655608,1.59295080619135e-06,1.01805765099734,4.79920701128237,28.2126225203342,2362.8544732838,2.12190639382976,4.03470202806197e-20,19.3941885333947,21.793565475171,5246.53379470447,1.03505008297772e-27,"lineage2","dr_mutations_pyrazinamide","ARG",0,"14MT_16115","SRR5526785","lineage2.2.1.1","pg","","pnca_p.trp68arg","A","B","TRP","WA68","pnca_complex.pdb"
|
|
"W68R","L4","PZA","W","W68",68,"R",1,"Pre-XDR","DM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",4.974,-0.576,-1.608,0.0790982,-1.263,-1.5,89,91,-1.146,9,9,45,0.157894736842105,"strand",-1.1,5.49,0.0020123616501365,132.405612244898,132.40553086776,132.608758225219,119.023328875182,-18,-32,0,0,-32,0,0,0,0,-2,0,-2,0,0,0,0,0,-1,0,-4,3,2,0,0,-2,-0.145896656534954,-0.415503875968992,0.00288092861981803,-0.215345268542199,-0.392670157068063,0.936842105263158,-0.943986820428336,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.124,"9:9","150/150","F:W",4.88586941655608,1.59295080619135e-06,1.01805765099734,4.79920701128237,28.2126225203342,2362.8544732838,2.12190639382976,4.03470202806197e-20,19.3941885333947,21.793565475171,5246.53379470447,1.03505008297772e-27,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERR2510852","ERR2510852","lineage4.8","it","Italy","pnca_p.trp68arg","A","B","TRP","WA68","pnca_complex.pdb"
|
|
"W68R","L2","PZA","W","W68",68,"R",1,"MDR","DM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",4.974,-0.576,-1.608,0.0790982,-1.263,-1.5,89,91,-1.146,9,9,45,0.157894736842105,"strand",-1.1,5.49,0.0020123616501365,132.405612244898,132.40553086776,132.608758225219,119.023328875182,-18,-32,0,0,-32,0,0,0,0,-2,0,-2,0,0,0,0,0,-1,0,-4,3,2,0,0,-2,-0.145896656534954,-0.415503875968992,0.00288092861981803,-0.215345268542199,-0.392670157068063,0.936842105263158,-0.943986820428336,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.124,"9:9","150/150","F:W",4.88586941655608,1.59295080619135e-06,1.01805765099734,4.79920701128237,28.2126225203342,2362.8544732838,2.12190639382976,4.03470202806197e-20,19.3941885333947,21.793565475171,5246.53379470447,1.03505008297772e-27,"lineage2","dr_mutations_pyrazinamide","ARG",0,"14MT_13367","SRR5526351","lineage2.2.1.1","pg","","pnca_p.trp68arg","A","B","TRP","WA68","pnca_complex.pdb"
|
|
"W68R","L2","PZA","W","W68",68,"R",1,"MDR","DM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",4.974,-0.576,-1.608,0.0790982,-1.263,-1.5,89,91,-1.146,9,9,45,0.157894736842105,"strand",-1.1,5.49,0.0020123616501365,132.405612244898,132.40553086776,132.608758225219,119.023328875182,-18,-32,0,0,-32,0,0,0,0,-2,0,-2,0,0,0,0,0,-1,0,-4,3,2,0,0,-2,-0.145896656534954,-0.415503875968992,0.00288092861981803,-0.215345268542199,-0.392670157068063,0.936842105263158,-0.943986820428336,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.124,"9:9","150/150","F:W",4.88586941655608,1.59295080619135e-06,1.01805765099734,4.79920701128237,28.2126225203342,2362.8544732838,2.12190639382976,4.03470202806197e-20,19.3941885333947,21.793565475171,5246.53379470447,1.03505008297772e-27,"lineage2","dr_mutations_pyrazinamide","ARG",0,"14MT_9930","SRR5533143","lineage2.2.1.1","pg","","pnca_p.trp68arg","A","B","TRP","WA68","pnca_complex.pdb"
|
|
"W68R","L2","PZA","W","W68",68,"R",1,"XDR","DM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",4.974,-0.576,-1.608,0.0790982,-1.263,-1.5,89,91,-1.146,9,9,45,0.157894736842105,"strand",-1.1,5.49,0.0020123616501365,132.405612244898,132.40553086776,132.608758225219,119.023328875182,-18,-32,0,0,-32,0,0,0,0,-2,0,-2,0,0,0,0,0,-1,0,-4,3,2,0,0,-2,-0.145896656534954,-0.415503875968992,0.00288092861981803,-0.215345268542199,-0.392670157068063,0.936842105263158,-0.943986820428336,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.124,"9:9","150/150","F:W",4.88586941655608,1.59295080619135e-06,1.01805765099734,4.79920701128237,28.2126225203342,2362.8544732838,2.12190639382976,4.03470202806197e-20,19.3941885333947,21.793565475171,5246.53379470447,1.03505008297772e-27,"lineage2","dr_mutations_pyrazinamide","ARG",0,"1522F-sc-2012-02-21T11:36:49Z-1364735,ERR137243","ERR137243","lineage2.2.1","ru","Russia,Samara","pnca_p.trp68arg","A","B","TRP","WA68","pnca_complex.pdb"
|
|
"W68R","L2","PZA","W","W68",68,"R",1,"MDR","DM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",4.974,-0.576,-1.608,0.0790982,-1.263,-1.5,89,91,-1.146,9,9,45,0.157894736842105,"strand",-1.1,5.49,0.0020123616501365,132.405612244898,132.40553086776,132.608758225219,119.023328875182,-18,-32,0,0,-32,0,0,0,0,-2,0,-2,0,0,0,0,0,-1,0,-4,3,2,0,0,-2,-0.145896656534954,-0.415503875968992,0.00288092861981803,-0.215345268542199,-0.392670157068063,0.936842105263158,-0.943986820428336,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.124,"9:9","150/150","F:W",4.88586941655608,1.59295080619135e-06,1.01805765099734,4.79920701128237,28.2126225203342,2362.8544732838,2.12190639382976,4.03470202806197e-20,19.3941885333947,21.793565475171,5246.53379470447,1.03505008297772e-27,"lineage2","dr_mutations_pyrazinamide","ARG",0,"14MT_20602","SRR5533249","lineage2.2.1.1","pg","","pnca_p.trp68arg","A","B","TRP","WA68","pnca_complex.pdb"
|
|
"W68R","L4","PZA","W","W68",68,"R",1,"Pre-XDR","DM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",4.974,-0.576,-1.608,0.0790982,-1.263,-1.5,89,91,-1.146,9,9,45,0.157894736842105,"strand",-1.1,5.49,0.0020123616501365,132.405612244898,132.40553086776,132.608758225219,119.023328875182,-18,-32,0,0,-32,0,0,0,0,-2,0,-2,0,0,0,0,0,-1,0,-4,3,2,0,0,-2,-0.145896656534954,-0.415503875968992,0.00288092861981803,-0.215345268542199,-0.392670157068063,0.936842105263158,-0.943986820428336,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.124,"9:9","150/150","F:W",4.88586941655608,1.59295080619135e-06,1.01805765099734,4.79920701128237,28.2126225203342,2362.8544732838,2.12190639382976,4.03470202806197e-20,19.3941885333947,21.793565475171,5246.53379470447,1.03505008297772e-27,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERR2510520","ERR2510520","lineage4.2.2","pk","Pakistan","pnca_p.trp68arg","A","B","TRP","WA68","pnca_complex.pdb"
|
|
"W68S","L2","PZA","W","W68",68,"S",NA,"XDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",4.974,-1.036,-2.673,2.64788,-1.343,-3.09,86,91,-1.146,9,9,45,0.157894736842105,"strand",-1.1,5.49,7.18700589334483e-05,9.70142977291842,188179.926264399,Inf,0.763784339928386,48,0,0,0,0,0,0,0,0,-2,0,-2,0,0,0,0,0,0,0,0,0,4,0,2,4,-0.26241134751773,-0.690697674418605,0.0964415533329934,-0.228985507246377,-0.808900523560209,0.905263157894737,-0.943986820428336,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.124,"9:9","150/150","F:W",12.1451538387252,0.919026337424192,119.468044436157,0.101660271548309,5.01153666069715e-06,NA,0.986835744238421,0.170978870202674,0.767057556984365,0.124324963210678,Inf,0.382146811758261,"lineage2","dr_mutations_pyrazinamide","SER",0,"SAMN02360558","SRR1048856_SRR1048857_SRR1013557_SRR1013558","lineage2.2.2","kr","South Korea","pnca_p.trp68ser","A","B","TRP","WA68","pnca_complex.pdb"
|
|
"W68S","L3","PZA","W","W68",68,"S",1,"Pre-XDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",4.974,-1.036,-2.673,2.64788,-1.343,-3.09,86,91,-1.146,9,9,45,0.157894736842105,"strand",-1.1,5.49,7.18700589334483e-05,9.70142977291842,188179.926264399,Inf,0.763784339928386,48,0,0,0,0,0,0,0,0,-2,0,-2,0,0,0,0,0,0,0,0,0,4,0,2,4,-0.26241134751773,-0.690697674418605,0.0964415533329934,-0.228985507246377,-0.808900523560209,0.905263157894737,-0.943986820428336,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.124,"9:9","150/150","F:W",12.1451538387252,0.919026337424192,119.468044436157,0.101660271548309,5.01153666069715e-06,NA,0.986835744238421,0.170978870202674,0.767057556984365,0.124324963210678,Inf,0.382146811758261,"lineage3","dr_mutations_pyrazinamide","SER",0,"ERR2510377","ERR2510377","lineage3","pk","Pakistan","pnca_p.trp68ser","A","B","TRP","WA68","pnca_complex.pdb"
|
|
"P69L","L2","PZA","P","P69",69,"L",1,"Pre-XDR","DM","hydrophilic","hydrophobic","non-polar","non-polar","non-polar","non-polar",7.994,-1.774,0.046,2.773,-1.421,-0.28,71,85,-1.198,9,9,23,0.144654088050314,"loop",-1.36666666666667,4.65,0.0004312203536006,24.2923336141533,24.2923334241601,24.2833096922897,14.1977442691074,-12,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-1,0,-1,0,-4,0,-2,0,-0.449341438703141,0.0391156462585034,0.100998696086073,-0.24228473998295,-0.0732984293193717,0.747368421052632,-0.986820428336079,"Destabilising","Stabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","150/150","P",3.19016080361873,0.0035954281300594,1.09565968954934,2.91163472932996,3.91551977432241,465.531063220338,1.38546923679232,0.0007494070007895,3.12528225414311,2.71567844828345,1141.60089496884,0.0001645676755807,"lineage2","dr_mutations_pyrazinamide","LEU",0,"ERS2592804","ERR2677460","lineage2.2.1","de","Germany","pnca_p.pro69leu","A","-","PRO","PA69","pnca_complex.pdb"
|
|
"P69L","L4","PZA","P","P69",69,"L",NA,"XDR","DM","hydrophilic","hydrophobic","non-polar","non-polar","non-polar","non-polar",7.994,-1.774,0.046,2.773,-1.421,-0.28,71,85,-1.198,9,9,23,0.144654088050314,"loop",-1.36666666666667,4.65,0.0004312203536006,24.2923336141533,24.2923334241601,24.2833096922897,14.1977442691074,-12,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-1,0,-1,0,-4,0,-2,0,-0.449341438703141,0.0391156462585034,0.100998696086073,-0.24228473998295,-0.0732984293193717,0.747368421052632,-0.986820428336079,"Destabilising","Stabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","150/150","P",3.19016080361873,0.0035954281300594,1.09565968954934,2.91163472932996,3.91551977432241,465.531063220338,1.38546923679232,0.0007494070007895,3.12528225414311,2.71567844828345,1141.60089496884,0.0001645676755807,"lineage4","dr_mutations_pyrazinamide","LEU",0,"ERR275214","ERR275214","lineage4.3.4.1","pt","Portugal","pnca_p.pro69leu","A","-","PRO","PA69","pnca_complex.pdb"
|
|
"P69L","L2","PZA","P","P69",69,"L",1,"Pre-XDR","DM","hydrophilic","hydrophobic","non-polar","non-polar","non-polar","non-polar",7.994,-1.774,0.046,2.773,-1.421,-0.28,71,85,-1.198,9,9,23,0.144654088050314,"loop",-1.36666666666667,4.65,0.0004312203536006,24.2923336141533,24.2923334241601,24.2833096922897,14.1977442691074,-12,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-1,0,-1,0,-4,0,-2,0,-0.449341438703141,0.0391156462585034,0.100998696086073,-0.24228473998295,-0.0732984293193717,0.747368421052632,-0.986820428336079,"Destabilising","Stabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","150/150","P",3.19016080361873,0.0035954281300594,1.09565968954934,2.91163472932996,3.91551977432241,465.531063220338,1.38546923679232,0.0007494070007895,3.12528225414311,2.71567844828345,1141.60089496884,0.0001645676755807,"lineage2","dr_mutations_pyrazinamide","LEU",0,"ERS2592794","ERR2677449","lineage2.2.1","de","Germany","pnca_p.pro69leu","A","-","PRO","PA69","pnca_complex.pdb"
|
|
"P69L","L2","PZA","P","P69",69,"L",1,"MDR","DM","hydrophilic","hydrophobic","non-polar","non-polar","non-polar","non-polar",7.994,-1.774,0.046,2.773,-1.421,-0.28,71,85,-1.198,9,9,23,0.144654088050314,"loop",-1.36666666666667,4.65,0.0004312203536006,24.2923336141533,24.2923334241601,24.2833096922897,14.1977442691074,-12,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-1,0,-1,0,-4,0,-2,0,-0.449341438703141,0.0391156462585034,0.100998696086073,-0.24228473998295,-0.0732984293193717,0.747368421052632,-0.986820428336079,"Destabilising","Stabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","150/150","P",3.19016080361873,0.0035954281300594,1.09565968954934,2.91163472932996,3.91551977432241,465.531063220338,1.38546923679232,0.0007494070007895,3.12528225414311,2.71567844828345,1141.60089496884,0.0001645676755807,"lineage2","dr_mutations_pyrazinamide","LEU",0,"ERR2510878","ERR2510878","lineage2.2.1","it","Italy","pnca_p.pro69leu","A","-","PRO","PA69","pnca_complex.pdb"
|
|
"P69L","L2;L4","PZA","P","P69",69,"L",0,"MDR","DM","hydrophilic","hydrophobic","non-polar","non-polar","non-polar","non-polar",7.994,-1.774,0.046,2.773,-1.421,-0.28,71,85,-1.198,9,9,23,0.144654088050314,"loop",-1.36666666666667,4.65,0.0004312203536006,24.2923336141533,24.2923334241601,24.2833096922897,14.1977442691074,-12,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-1,0,-1,0,-4,0,-2,0,-0.449341438703141,0.0391156462585034,0.100998696086073,-0.24228473998295,-0.0732984293193717,0.747368421052632,-0.986820428336079,"Destabilising","Stabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","150/150","P",3.19016080361873,0.0035954281300594,1.09565968954934,2.91163472932996,3.91551977432241,465.531063220338,1.38546923679232,0.0007494070007895,3.12528225414311,2.71567844828345,1141.60089496884,0.0001645676755807,"lineage2;lineage4","dr_mutations_pyrazinamide","LEU",0,"SRR6339637","SRR6339637","lineage4.1.2.1;lineage2.2.1","au","Australia","pnca_p.pro69leu","A","-","PRO","PA69","pnca_complex.pdb"
|
|
"P69L","L4","PZA","P","P69",69,"L",NA,"Other","DM","hydrophilic","hydrophobic","non-polar","non-polar","non-polar","non-polar",7.994,-1.774,0.046,2.773,-1.421,-0.28,71,85,-1.198,9,9,23,0.144654088050314,"loop",-1.36666666666667,4.65,0.0004312203536006,24.2923336141533,24.2923334241601,24.2833096922897,14.1977442691074,-12,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-1,0,-1,0,-4,0,-2,0,-0.449341438703141,0.0391156462585034,0.100998696086073,-0.24228473998295,-0.0732984293193717,0.747368421052632,-0.986820428336079,"Destabilising","Stabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","150/150","P",3.19016080361873,0.0035954281300594,1.09565968954934,2.91163472932996,3.91551977432241,465.531063220338,1.38546923679232,0.0007494070007895,3.12528225414311,2.71567844828345,1141.60089496884,0.0001645676755807,"lineage4","dr_mutations_pyrazinamide","LEU",0,"SAMN02585950","SRR1180428_SRR1181133_SRR1181169_SRR1180322","lineage4.1.1.3","za","South Africa","pnca_p.pro69leu","A","-","PRO","PA69","pnca_complex.pdb"
|
|
"P69L","L4","PZA","P","P69",69,"L",1,"MDR","DM","hydrophilic","hydrophobic","non-polar","non-polar","non-polar","non-polar",7.994,-1.774,0.046,2.773,-1.421,-0.28,71,85,-1.198,9,9,23,0.144654088050314,"loop",-1.36666666666667,4.65,0.0004312203536006,24.2923336141533,24.2923334241601,24.2833096922897,14.1977442691074,-12,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-1,0,-1,0,-4,0,-2,0,-0.449341438703141,0.0391156462585034,0.100998696086073,-0.24228473998295,-0.0732984293193717,0.747368421052632,-0.986820428336079,"Destabilising","Stabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","150/150","P",3.19016080361873,0.0035954281300594,1.09565968954934,2.91163472932996,3.91551977432241,465.531063220338,1.38546923679232,0.0007494070007895,3.12528225414311,2.71567844828345,1141.60089496884,0.0001645676755807,"lineage4","dr_mutations_pyrazinamide","LEU",0,"ERR2864254","ERR2864254","lineage4.3.4.1","pt","Portugal","pnca_p.pro69leu","A","-","PRO","PA69","pnca_complex.pdb"
|
|
"P69L","L4","PZA","P","P69",69,"L",NA,"XDR","DM","hydrophilic","hydrophobic","non-polar","non-polar","non-polar","non-polar",7.994,-1.774,0.046,2.773,-1.421,-0.28,71,85,-1.198,9,9,23,0.144654088050314,"loop",-1.36666666666667,4.65,0.0004312203536006,24.2923336141533,24.2923334241601,24.2833096922897,14.1977442691074,-12,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-1,0,-1,0,-4,0,-2,0,-0.449341438703141,0.0391156462585034,0.100998696086073,-0.24228473998295,-0.0732984293193717,0.747368421052632,-0.986820428336079,"Destabilising","Stabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","150/150","P",3.19016080361873,0.0035954281300594,1.09565968954934,2.91163472932996,3.91551977432241,465.531063220338,1.38546923679232,0.0007494070007895,3.12528225414311,2.71567844828345,1141.60089496884,0.0001645676755807,"lineage4","dr_mutations_pyrazinamide","LEU",0,"ERR1034907","ERR1034907","lineage4.3.4.1","pt","Portugal","pnca_p.pro69leu","A","-","PRO","PA69","pnca_complex.pdb"
|
|
"P69L","L4","PZA","P","P69",69,"L",NA,"XDR","DM","hydrophilic","hydrophobic","non-polar","non-polar","non-polar","non-polar",7.994,-1.774,0.046,2.773,-1.421,-0.28,71,85,-1.198,9,9,23,0.144654088050314,"loop",-1.36666666666667,4.65,0.0004312203536006,24.2923336141533,24.2923334241601,24.2833096922897,14.1977442691074,-12,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-1,0,-1,0,-4,0,-2,0,-0.449341438703141,0.0391156462585034,0.100998696086073,-0.24228473998295,-0.0732984293193717,0.747368421052632,-0.986820428336079,"Destabilising","Stabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","150/150","P",3.19016080361873,0.0035954281300594,1.09565968954934,2.91163472932996,3.91551977432241,465.531063220338,1.38546923679232,0.0007494070007895,3.12528225414311,2.71567844828345,1141.60089496884,0.0001645676755807,"lineage4","dr_mutations_pyrazinamide","LEU",0,"ERR1035233","ERR1035233","lineage4.3.4.1","pt","Portugal","pnca_p.pro69leu","A","-","PRO","PA69","pnca_complex.pdb"
|
|
"P69L","L4","PZA","P","P69",69,"L",1,"Pre-XDR","DM","hydrophilic","hydrophobic","non-polar","non-polar","non-polar","non-polar",7.994,-1.774,0.046,2.773,-1.421,-0.28,71,85,-1.198,9,9,23,0.144654088050314,"loop",-1.36666666666667,4.65,0.0004312203536006,24.2923336141533,24.2923334241601,24.2833096922897,14.1977442691074,-12,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-1,0,-1,0,-4,0,-2,0,-0.449341438703141,0.0391156462585034,0.100998696086073,-0.24228473998295,-0.0732984293193717,0.747368421052632,-0.986820428336079,"Destabilising","Stabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","150/150","P",3.19016080361873,0.0035954281300594,1.09565968954934,2.91163472932996,3.91551977432241,465.531063220338,1.38546923679232,0.0007494070007895,3.12528225414311,2.71567844828345,1141.60089496884,0.0001645676755807,"lineage4","dr_mutations_pyrazinamide","LEU",0,"MDR_23408","SRR6824484","lineage4.4.2","cn","China: Jiangyou City, Mianyang City, Sichuan Province","pnca_p.pro69leu","A","-","PRO","PA69","pnca_complex.pdb"
|
|
"P69L","L4","PZA","P","P69",69,"L",NA,"MDR","DM","hydrophilic","hydrophobic","non-polar","non-polar","non-polar","non-polar",7.994,-1.774,0.046,2.773,-1.421,-0.28,71,85,-1.198,9,9,23,0.144654088050314,"loop",-1.36666666666667,4.65,0.0004312203536006,24.2923336141533,24.2923334241601,24.2833096922897,14.1977442691074,-12,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-1,0,-1,0,-4,0,-2,0,-0.449341438703141,0.0391156462585034,0.100998696086073,-0.24228473998295,-0.0732984293193717,0.747368421052632,-0.986820428336079,"Destabilising","Stabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","150/150","P",3.19016080361873,0.0035954281300594,1.09565968954934,2.91163472932996,3.91551977432241,465.531063220338,1.38546923679232,0.0007494070007895,3.12528225414311,2.71567844828345,1141.60089496884,0.0001645676755807,"lineage4","dr_mutations_pyrazinamide","LEU",0,"ERR2679262","ERR2679262","lineage4.1","","","pnca_p.pro69leu","A","-","PRO","PA69","pnca_complex.pdb"
|
|
"P69L","L5","PZA","P","P69",69,"L",NA,"MDR","DM","hydrophilic","hydrophobic","non-polar","non-polar","non-polar","non-polar",7.994,-1.774,0.046,2.773,-1.421,-0.28,71,85,-1.198,9,9,23,0.144654088050314,"loop",-1.36666666666667,4.65,0.0004312203536006,24.2923336141533,24.2923334241601,24.2833096922897,14.1977442691074,-12,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-1,0,-1,0,-4,0,-2,0,-0.449341438703141,0.0391156462585034,0.100998696086073,-0.24228473998295,-0.0732984293193717,0.747368421052632,-0.986820428336079,"Destabilising","Stabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","150/150","P",3.19016080361873,0.0035954281300594,1.09565968954934,2.91163472932996,3.91551977432241,465.531063220338,1.38546923679232,0.0007494070007895,3.12528225414311,2.71567844828345,1141.60089496884,0.0001645676755807,"lineage5","dr_mutations_pyrazinamide","LEU",0,"ERR3170486","ERR3170486","lineage5","gh","Ghana","pnca_p.pro69leu","A","-","PRO","PA69","pnca_complex.pdb"
|
|
"P69Q","L3","PZA","P","P69",69,"Q",0,"Pre-MDR","OM","hydrophilic","hydrophilic","non-polar","neutral","non-polar","polar",7.994,-0.293,-1.59,2.83344,-1.339,-0.94,71,85,-1.198,9,9,23,0.144654088050314,"loop",-1.36666666666667,4.65,7.18700589334483e-05,2.42412778478352,0.0001249735077034,0,1.03410070803344e-29,-12,0,0,0,0,0,0,0,0,-2,0,-2,0,0,0,0,0,-6,0,-2,-5,-8,0,-2,-2,-0.0742147922998986,-0.410852713178295,0.103200052447934,-0.228303495311168,-0.246073298429319,0.747368421052632,-0.986820428336079,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","150/150","P",-8.98740878149641,0.940032862253634,119.468044435492,-0.0752285585987744,NA,4692673.51081431,0.384555509373631,1,0,0,188.544222231268,0.999999999999997,"lineage3","other_mutations_pyrazinamide","GLN",0,"ERR3335782","ERR3335782","lineage3","pk","Pakistan","pnca_p.pro69gln","A","-","PRO","PA69","pnca_complex.pdb"
|
|
"P69R","L2","PZA","P","P69",69,"R",NA,"XDR","DM","hydrophilic","hydrophilic","non-polar","basic","non-polar","pos",7.994,-0.966,-1.258,2.33826,-1.319,-1.24,77,85,-1.198,9,9,23,0.144654088050314,"loop",-1.36666666666667,4.65,7.18700589334483e-05,2.42412778478352,0.0001249735077034,0,1.03410070803344e-29,-46,-14,0,0,-14,0,0,0,0,-2,0,-2,0,0,0,0,0,-8,0,-2,-7,-6,0,0,-2,-0.24468085106383,-0.325064599483204,0.0851645189723119,-0.224893435635124,-0.324607329842932,0.810526315789474,-0.986820428336079,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","150/150","P",-8.98740878149642,0.940032862253634,119.468044435493,-0.0752285585987743,NA,4692673.51081303,0.384555509373631,1,0,0,188.544222231268,0.999999999999997,"lineage2","dr_mutations_pyrazinamide","ARG",0,"SAMN02628504","SRR1173192_SRR1173793","lineage2.2.1","ir","Iran","pnca_p.pro69arg","A","-","PRO","PA69","pnca_complex.pdb"
|
|
"P69R","L3","PZA","P","P69",69,"R",0,"Pre-XDR","DM","hydrophilic","hydrophilic","non-polar","basic","non-polar","pos",7.994,-0.966,-1.258,2.33826,-1.319,-1.24,77,85,-1.198,9,9,23,0.144654088050314,"loop",-1.36666666666667,4.65,7.18700589334483e-05,2.42412778478352,0.0001249735077034,0,1.03410070803344e-29,-46,-14,0,0,-14,0,0,0,0,-2,0,-2,0,0,0,0,0,-8,0,-2,-7,-6,0,0,-2,-0.24468085106383,-0.325064599483204,0.0851645189723119,-0.224893435635124,-0.324607329842932,0.810526315789474,-0.986820428336079,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","150/150","P",-8.98740878149642,0.940032862253634,119.468044435493,-0.0752285585987743,NA,4692673.51081303,0.384555509373631,1,0,0,188.544222231268,0.999999999999997,"lineage3","dr_mutations_pyrazinamide","ARG",0,"ERR2510861","ERR2510861","lineage3","pk","Pakistan","pnca_p.pro69arg","A","-","PRO","PA69","pnca_complex.pdb"
|
|
"P69R","L2","PZA","P","P69",69,"R",NA,"MDR","DM","hydrophilic","hydrophilic","non-polar","basic","non-polar","pos",7.994,-0.966,-1.258,2.33826,-1.319,-1.24,77,85,-1.198,9,9,23,0.144654088050314,"loop",-1.36666666666667,4.65,7.18700589334483e-05,2.42412778478352,0.0001249735077034,0,1.03410070803344e-29,-46,-14,0,0,-14,0,0,0,0,-2,0,-2,0,0,0,0,0,-8,0,-2,-7,-6,0,0,-2,-0.24468085106383,-0.325064599483204,0.0851645189723119,-0.224893435635124,-0.324607329842932,0.810526315789474,-0.986820428336079,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","150/150","P",-8.98740878149642,0.940032862253634,119.468044435493,-0.0752285585987743,NA,4692673.51081303,0.384555509373631,1,0,0,188.544222231268,0.999999999999997,"lineage2","dr_mutations_pyrazinamide","ARG",0,"ERR2516018","ERR2516018","lineage2.2.1.1","za","South Africa","pnca_p.pro69arg","A","-","PRO","PA69","pnca_complex.pdb"
|
|
"P69R","L2","PZA","P","P69",69,"R",NA,"XDR","DM","hydrophilic","hydrophilic","non-polar","basic","non-polar","pos",7.994,-0.966,-1.258,2.33826,-1.319,-1.24,77,85,-1.198,9,9,23,0.144654088050314,"loop",-1.36666666666667,4.65,7.18700589334483e-05,2.42412778478352,0.0001249735077034,0,1.03410070803344e-29,-46,-14,0,0,-14,0,0,0,0,-2,0,-2,0,0,0,0,0,-8,0,-2,-7,-6,0,0,-2,-0.24468085106383,-0.325064599483204,0.0851645189723119,-0.224893435635124,-0.324607329842932,0.810526315789474,-0.986820428336079,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","150/150","P",-8.98740878149642,0.940032862253634,119.468044435493,-0.0752285585987743,NA,4692673.51081303,0.384555509373631,1,0,0,188.544222231268,0.999999999999997,"lineage2","dr_mutations_pyrazinamide","ARG",0,"SAMN02628505","SRR1173131_SRR1173875","lineage2.2.1","ir","Iran","pnca_p.pro69arg","A","-","PRO","PA69","pnca_complex.pdb"
|
|
"P69S","L4","PZA","P","P69",69,"S",NA,"Pre-XDR","OM","hydrophilic","hydrophilic","non-polar","neutral","non-polar","polar",7.994,-0.353,-2.477,3.28838,-1.447,-1.93,73,85,-1.198,9,9,23,0.144654088050314,"loop",-1.36666666666667,4.65,0.0001437401178668,1.2119588062211,4.59700131334263e-05,0,1.01056822389159e-25,0,0,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,-1,0,-1,0,2,0,2,2,-0.0894123606889564,-0.640051679586563,0.119769957531742,-0.246717817561807,-0.505235602094241,0.768421052631579,-0.986820428336079,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","150/150","P",-9.98752126245059,0.942832958100734,139.277183325398,-0.0717096729269462,NA,144471.706314845,0.0834878586628579,1,0,0,25.8386585962163,0.999999999999746,"lineage4","other_mutations_pyrazinamide","SER",0,"ERR2707003","ERR2707003","lineage4.4.1.2","cd","Democratic Republic of Congo","pnca_p.pro69ser","A","-","PRO","PA69","pnca_complex.pdb"
|
|
"P69S","L3","PZA","P","P69",69,"S",NA,"Sensitive","OM","hydrophilic","hydrophilic","non-polar","neutral","non-polar","polar",7.994,-0.353,-2.477,3.28838,-1.447,-1.93,73,85,-1.198,9,9,23,0.144654088050314,"loop",-1.36666666666667,4.65,0.0001437401178668,1.2119588062211,4.59700131334263e-05,0,1.01056822389159e-25,0,0,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,-1,0,-1,0,2,0,2,2,-0.0894123606889564,-0.640051679586563,0.119769957531742,-0.246717817561807,-0.505235602094241,0.768421052631579,-0.986820428336079,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","150/150","P",-9.98752126245059,0.942832958100734,139.277183325398,-0.0717096729269462,NA,144471.706314845,0.0834878586628579,1,0,0,25.8386585962163,0.999999999999746,"lineage3","other_mutations_pyrazinamide","SER",0,"SRR6398121","SRR6398121","lineage3","ca","Canada","pnca_p.pro69ser","A","-","PRO","PA69","pnca_complex.pdb"
|
|
"P69S","L4","PZA","P","P69",69,"S",NA,"MDR","OM","hydrophilic","hydrophilic","non-polar","neutral","non-polar","polar",7.994,-0.353,-2.477,3.28838,-1.447,-1.93,73,85,-1.198,9,9,23,0.144654088050314,"loop",-1.36666666666667,4.65,0.0001437401178668,1.2119588062211,4.59700131334263e-05,0,1.01056822389159e-25,0,0,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,-1,0,-1,0,2,0,2,2,-0.0894123606889564,-0.640051679586563,0.119769957531742,-0.246717817561807,-0.505235602094241,0.768421052631579,-0.986820428336079,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","150/150","P",-9.98752126245059,0.942832958100734,139.277183325398,-0.0717096729269462,NA,144471.706314845,0.0834878586628579,1,0,0,25.8386585962163,0.999999999999746,"lineage4","other_mutations_pyrazinamide","SER",0,"ERR2707088","ERR2707088","lineage4.3.4.1","cd","Democratic Republic of Congo","pnca_p.pro69ser","A","-","PRO","PA69","pnca_complex.pdb"
|
|
"P69S","L4;L6","PZA","P","P69",69,"S",NA,"Pre-MDR","OM","hydrophilic","hydrophilic","non-polar","neutral","non-polar","polar",7.994,-0.353,-2.477,3.28838,-1.447,-1.93,73,85,-1.198,9,9,23,0.144654088050314,"loop",-1.36666666666667,4.65,0.0001437401178668,1.2119588062211,4.59700131334263e-05,0,1.01056822389159e-25,0,0,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,-1,0,-1,0,2,0,2,2,-0.0894123606889564,-0.640051679586563,0.119769957531742,-0.246717817561807,-0.505235602094241,0.768421052631579,-0.986820428336079,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","150/150","P",-9.98752126245059,0.942832958100734,139.277183325398,-0.0717096729269462,NA,144471.706314845,0.0834878586628579,1,0,0,25.8386585962163,0.999999999999746,"lineage4;lineage6","other_mutations_pyrazinamide","SER",0,"ERR702427","ERR702427","lineage6;lineage4.6.2.2","gh","Ghana","pnca_p.pro69ser","A","-","PRO","PA69","pnca_complex.pdb"
|
|
"P69S","L3","PZA","P","P69",69,"S",0,"Pre-XDR","OM","hydrophilic","hydrophilic","non-polar","neutral","non-polar","polar",7.994,-0.353,-2.477,3.28838,-1.447,-1.93,73,85,-1.198,9,9,23,0.144654088050314,"loop",-1.36666666666667,4.65,0.0001437401178668,1.2119588062211,4.59700131334263e-05,0,1.01056822389159e-25,0,0,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,-1,0,-1,0,2,0,2,2,-0.0894123606889564,-0.640051679586563,0.119769957531742,-0.246717817561807,-0.505235602094241,0.768421052631579,-0.986820428336079,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","150/150","P",-9.98752126245059,0.942832958100734,139.277183325398,-0.0717096729269462,NA,144471.706314845,0.0834878586628579,1,0,0,25.8386585962163,0.999999999999746,"lineage3","other_mutations_pyrazinamide","SER",0,"ERR2510365","ERR2510365","lineage3","pk","Pakistan","pnca_p.pro69ser","A","-","PRO","PA69","pnca_complex.pdb"
|
|
"P69S","L4","PZA","P","P69",69,"S",0,"Sensitive","OM","hydrophilic","hydrophilic","non-polar","neutral","non-polar","polar",7.994,-0.353,-2.477,3.28838,-1.447,-1.93,73,85,-1.198,9,9,23,0.144654088050314,"loop",-1.36666666666667,4.65,0.0001437401178668,1.2119588062211,4.59700131334263e-05,0,1.01056822389159e-25,0,0,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,-1,0,-1,0,2,0,2,2,-0.0894123606889564,-0.640051679586563,0.119769957531742,-0.246717817561807,-0.505235602094241,0.768421052631579,-0.986820428336079,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","150/150","P",-9.98752126245059,0.942832958100734,139.277183325398,-0.0717096729269462,NA,144471.706314845,0.0834878586628579,1,0,0,25.8386585962163,0.999999999999746,"lineage4","other_mutations_pyrazinamide","SER",0,"SAMEA2535333,ERR553359","ERR553359","lineage4.6.2.2","","","pnca_p.pro69ser","A","-","PRO","PA69","pnca_complex.pdb"
|
|
"P69S","L3","PZA","P","P69",69,"S",NA,"Sensitive","OM","hydrophilic","hydrophilic","non-polar","neutral","non-polar","polar",7.994,-0.353,-2.477,3.28838,-1.447,-1.93,73,85,-1.198,9,9,23,0.144654088050314,"loop",-1.36666666666667,4.65,0.0001437401178668,1.2119588062211,4.59700131334263e-05,0,1.01056822389159e-25,0,0,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,-1,0,-1,0,2,0,2,2,-0.0894123606889564,-0.640051679586563,0.119769957531742,-0.246717817561807,-0.505235602094241,0.768421052631579,-0.986820428336079,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","150/150","P",-9.98752126245059,0.942832958100734,139.277183325398,-0.0717096729269462,NA,144471.706314845,0.0834878586628579,1,0,0,25.8386585962163,0.999999999999746,"lineage3","other_mutations_pyrazinamide","SER",0,"SRR6397659","SRR6397659","lineage3","ca","Canada","pnca_p.pro69ser","A","-","PRO","PA69","pnca_complex.pdb"
|
|
"P69S","L4","PZA","P","P69",69,"S",NA,"MDR","OM","hydrophilic","hydrophilic","non-polar","neutral","non-polar","polar",7.994,-0.353,-2.477,3.28838,-1.447,-1.93,73,85,-1.198,9,9,23,0.144654088050314,"loop",-1.36666666666667,4.65,0.0001437401178668,1.2119588062211,4.59700131334263e-05,0,1.01056822389159e-25,0,0,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,-1,0,-1,0,2,0,2,2,-0.0894123606889564,-0.640051679586563,0.119769957531742,-0.246717817561807,-0.505235602094241,0.768421052631579,-0.986820428336079,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","150/150","P",-9.98752126245059,0.942832958100734,139.277183325398,-0.0717096729269462,NA,144471.706314845,0.0834878586628579,1,0,0,25.8386585962163,0.999999999999746,"lineage4","other_mutations_pyrazinamide","SER",0,"ERR2706965","ERR2706965","lineage4.3.4.1","cd","Democratic Republic of Congo","pnca_p.pro69ser","A","-","PRO","PA69","pnca_complex.pdb"
|
|
"P69S","L4","PZA","P","P69",69,"S",NA,"Sensitive","OM","hydrophilic","hydrophilic","non-polar","neutral","non-polar","polar",7.994,-0.353,-2.477,3.28838,-1.447,-1.93,73,85,-1.198,9,9,23,0.144654088050314,"loop",-1.36666666666667,4.65,0.0001437401178668,1.2119588062211,4.59700131334263e-05,0,1.01056822389159e-25,0,0,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,-1,0,-1,0,2,0,2,2,-0.0894123606889564,-0.640051679586563,0.119769957531742,-0.246717817561807,-0.505235602094241,0.768421052631579,-0.986820428336079,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","150/150","P",-9.98752126245059,0.942832958100734,139.277183325398,-0.0717096729269462,NA,144471.706314845,0.0834878586628579,1,0,0,25.8386585962163,0.999999999999746,"lineage4","other_mutations_pyrazinamide","SER",0,"ERR751346","ERR751346","lineage4.6.2.2","gh","Ghana","pnca_p.pro69ser","A","-","PRO","PA69","pnca_complex.pdb"
|
|
"P69T","L4","PZA","P","P69",69,"T",NA,"Pre-MDR","OM","hydrophilic","hydrophobic","non-polar","neutral","non-polar","polar",7.994,-0.377,-1.905,2.75187,-1.735,-1.08,72,85,-1.198,9,9,23,0.144654088050314,"loop",-1.36666666666667,4.65,7.18700589334483e-05,9.70142977291842,188179.926264408,Inf,0.763784339928386,0,0,0,0,0,0,0,0,0,-2,0,-2,0,0,0,0,0,-1,0,-1,0,0,0,2,0,-0.0954913880445795,-0.492248062015504,0.100229095491663,-0.295822676896846,-0.282722513089005,0.757894736842105,-0.986820428336079,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","150/150","P",12.1451538387252,0.919026337424193,119.46804443616,0.101660271548307,5.01153666069443e-06,NA,0.986835744238421,0.170978870202674,0.767057556984365,0.124324963210678,Inf,0.382146811758261,"lineage4","other_mutations_pyrazinamide","THR",0,"ERR1213868","ERR1213868","lineage4.1.2.1","br","Brazil","pnca_p.pro69thr","A","-","PRO","PA69","pnca_complex.pdb"
|
|
"P69T","L4","PZA","P","P69",69,"T",1,"MDR","OM","hydrophilic","hydrophobic","non-polar","neutral","non-polar","polar",7.994,-0.377,-1.905,2.75187,-1.735,-1.08,72,85,-1.198,9,9,23,0.144654088050314,"loop",-1.36666666666667,4.65,7.18700589334483e-05,9.70142977291842,188179.926264408,Inf,0.763784339928386,0,0,0,0,0,0,0,0,0,-2,0,-2,0,0,0,0,0,-1,0,-1,0,0,0,2,0,-0.0954913880445795,-0.492248062015504,0.100229095491663,-0.295822676896846,-0.282722513089005,0.757894736842105,-0.986820428336079,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","150/150","P",12.1451538387252,0.919026337424193,119.46804443616,0.101660271548307,5.01153666069443e-06,NA,0.986835744238421,0.170978870202674,0.767057556984365,0.124324963210678,Inf,0.382146811758261,"lineage4","other_mutations_pyrazinamide","THR",0,"ERR3335768","ERR3335768","lineage4.5","pk","Pakistan","pnca_p.pro69thr","A","-","PRO","PA69","pnca_complex.pdb"
|
|
"H71D","L2","PZA","H","H71",71,"D",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.184,-2.498,-2.685,5.74525,-1.66,-2.6,82,91,-1.209,9,9,5,0.0223214285714285,"loop",-0.766666666666667,6.25,7.18700589334483e-05,9.70142977291842,188179.926264626,Inf,0.763784339928386,18,-24,0,0,-24,0,0,0,0,4,0,2,2,0,0,0,0,-3,0,-7,4,0,0,0,0,-0.632725430597771,-0.693798449612403,0.209254510886589,-0.283034953111679,-0.680628272251309,0.863157894736842,-0.995881383855025,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","150/150","H",12.1451538387264,0.919026337424233,119.468044436231,0.101660271548257,5.01153666062825e-06,NA,0.986835744238421,0.170978870202674,0.767057556984365,0.124324963210678,Inf,0.382146811758261,"lineage2","dr_mutations_pyrazinamide","ASP",0,"SRS797287","SRR1723816","lineage2.2.1","cn","China:Guangdong","pnca_p.his71asp","A","-","HIS","HA71","pnca_complex.pdb"
|
|
"H71D","L2","PZA","H","H71",71,"D",1,"Pre-XDR","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.184,-2.498,-2.685,5.74525,-1.66,-2.6,82,91,-1.209,9,9,5,0.0223214285714285,"loop",-0.766666666666667,6.25,7.18700589334483e-05,9.70142977291842,188179.926264626,Inf,0.763784339928386,18,-24,0,0,-24,0,0,0,0,4,0,2,2,0,0,0,0,-3,0,-7,4,0,0,0,0,-0.632725430597771,-0.693798449612403,0.209254510886589,-0.283034953111679,-0.680628272251309,0.863157894736842,-0.995881383855025,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","150/150","H",12.1451538387264,0.919026337424233,119.468044436231,0.101660271548257,5.01153666062825e-06,NA,0.986835744238421,0.170978870202674,0.767057556984365,0.124324963210678,Inf,0.382146811758261,"lineage2","dr_mutations_pyrazinamide","ASP",0,"MDR_19420","SRR6824410","lineage2.2.1","cn","China: Chaoan County, Chaozhou City, Guangdong Province","pnca_p.his71asp","A","-","HIS","HA71","pnca_complex.pdb"
|
|
"H71D","L4","PZA","H","H71",71,"D",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",4.184,-2.498,-2.685,5.74525,-1.66,-2.6,82,91,-1.209,9,9,5,0.0223214285714285,"loop",-0.766666666666667,6.25,7.18700589334483e-05,9.70142977291842,188179.926264626,Inf,0.763784339928386,18,-24,0,0,-24,0,0,0,0,4,0,2,2,0,0,0,0,-3,0,-7,4,0,0,0,0,-0.632725430597771,-0.693798449612403,0.209254510886589,-0.283034953111679,-0.680628272251309,0.863157894736842,-0.995881383855025,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","150/150","H",12.1451538387264,0.919026337424233,119.468044436231,0.101660271548257,5.01153666062825e-06,NA,0.986835744238421,0.170978870202674,0.767057556984365,0.124324963210678,Inf,0.382146811758261,"lineage4","dr_mutations_pyrazinamide","ASP",0,"SRR5818696","SRR5818696","lineage4.6","dj","Djibouti","pnca_p.his71asp","A","-","HIS","HA71","pnca_complex.pdb"
|
|
"H71N","L4","PZA","H","H71",71,"N",NA,"MDR","DM","hydrophobic","hydrophilic","basic","neutral","pos","polar",4.184,-1.335,-2.671,0.64378,-1.764,-2.6,70,85,-1.209,9,9,5,0.0223214285714285,"loop",-0.766666666666667,6.25,NA,NA,NA,NA,NA,16,6,0,0,6,0,0,0,0,-2,0,2,-4,0,0,0,0,1,0,-2,5,0,0,0,0,-0.338145896656535,-0.690180878552972,0.0234478689384392,-0.30076726342711,-0.680628272251309,0.736842105263158,-0.995881383855025,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","150/150","H",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage4","dr_mutations_pyrazinamide","ASN",0,"SAMN02567731","SRR1166325","lineage4.3.3","ro","Romania","pnca_p.his71asn","A","-","HIS","HA71","pnca_complex.pdb"
|
|
"H71P","L4","PZA","H","H71",71,"P",NA,"MDR","OM","hydrophobic","hydrophilic","basic","non-polar","pos","non-polar",4.184,-2.885,-2.362,3.26218,-1.555,-2.44,84,91,-1.209,9,9,5,0.0223214285714285,"loop",-0.766666666666667,6.25,0.0001437401178668,4.85029436501262,4.85029432717734,4.84956447904112,0.0881192621863332,32,8,0,0,8,0,0,0,0,2,0,2,0,0,0,0,0,-2,0,-4,2,0,0,0,0,-0.730749746707194,-0.610335917312661,0.118815696501286,-0.265132139812447,-0.638743455497382,0.884210526315789,-0.995881383855025,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","150/150","H",1.57903938912402,0.264247566376723,1.41439286276584,1.11640791656443,0.191756076673778,122.683760399245,0.685768096792206,0.312734154310187,0.504824686014995,0.061763864579114,379.558337204203,0.766581879696361,"lineage4","other_mutations_pyrazinamide","PRO",0,"3033","ERR2433011","lineage4.3.4.2.1","br","Momazbique","pnca_p.his71pro","A","-","HIS","HA71","pnca_complex.pdb"
|
|
"H71P","L2","PZA","H","H71",71,"P",NA,"XDR","OM","hydrophobic","hydrophilic","basic","non-polar","pos","non-polar",4.184,-2.885,-2.362,3.26218,-1.555,-2.44,84,91,-1.209,9,9,5,0.0223214285714285,"loop",-0.766666666666667,6.25,0.0001437401178668,4.85029436501262,4.85029432717734,4.84956447904112,0.0881192621863332,32,8,0,0,8,0,0,0,0,2,0,2,0,0,0,0,0,-2,0,-4,2,0,0,0,0,-0.730749746707194,-0.610335917312661,0.118815696501286,-0.265132139812447,-0.638743455497382,0.884210526315789,-0.995881383855025,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","150/150","H",1.57903938912402,0.264247566376723,1.41439286276584,1.11640791656443,0.191756076673778,122.683760399245,0.685768096792206,0.312734154310187,0.504824686014995,0.061763864579114,379.558337204203,0.766581879696361,"lineage2","other_mutations_pyrazinamide","PRO",0,"ERR2516719","ERR2516719","lineage2.2.1","nl","Netherlands","pnca_p.his71pro","A","-","HIS","HA71","pnca_complex.pdb"
|
|
"H71P","L2","PZA","H","H71",71,"P",1,"XDR","OM","hydrophobic","hydrophilic","basic","non-polar","pos","non-polar",4.184,-2.885,-2.362,3.26218,-1.555,-2.44,84,91,-1.209,9,9,5,0.0223214285714285,"loop",-0.766666666666667,6.25,0.0001437401178668,4.85029436501262,4.85029432717734,4.84956447904112,0.0881192621863332,32,8,0,0,8,0,0,0,0,2,0,2,0,0,0,0,0,-2,0,-4,2,0,0,0,0,-0.730749746707194,-0.610335917312661,0.118815696501286,-0.265132139812447,-0.638743455497382,0.884210526315789,-0.995881383855025,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","150/150","H",1.57903938912402,0.264247566376723,1.41439286276584,1.11640791656443,0.191756076673778,122.683760399245,0.685768096792206,0.312734154310187,0.504824686014995,0.061763864579114,379.558337204203,0.766581879696361,"lineage2","other_mutations_pyrazinamide","PRO",0,"ERS457857","ERR552165_ERR552164","lineage2.2.1","uz","Nukus","pnca_p.his71pro","A","-","HIS","HA71","pnca_complex.pdb"
|
|
"H71P","L2","PZA","H","H71",71,"P",0,"MDR","OM","hydrophobic","hydrophilic","basic","non-polar","pos","non-polar",4.184,-2.885,-2.362,3.26218,-1.555,-2.44,84,91,-1.209,9,9,5,0.0223214285714285,"loop",-0.766666666666667,6.25,0.0001437401178668,4.85029436501262,4.85029432717734,4.84956447904112,0.0881192621863332,32,8,0,0,8,0,0,0,0,2,0,2,0,0,0,0,0,-2,0,-4,2,0,0,0,0,-0.730749746707194,-0.610335917312661,0.118815696501286,-0.265132139812447,-0.638743455497382,0.884210526315789,-0.995881383855025,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","150/150","H",1.57903938912402,0.264247566376723,1.41439286276584,1.11640791656443,0.191756076673778,122.683760399245,0.685768096792206,0.312734154310187,0.504824686014995,0.061763864579114,379.558337204203,0.766581879696361,"lineage2","other_mutations_pyrazinamide","PRO",0,"MDR_14347","SRR6824431","lineage2.2.1.1","cn","China: Guangfeng County, Shangrao City, Jiangxi Province","pnca_p.his71pro","A","-","HIS","HA71","pnca_complex.pdb"
|
|
"H71Q","L2","PZA","H","H71",71,"Q",NA,"XDR","DM","hydrophobic","hydrophilic","basic","neutral","pos","polar",4.184,-1.733,-2.294,1.12335,-1.091,-1.86,67,80,-1.209,9,9,5,0.0223214285714285,"loop",-0.766666666666667,6.25,0.0001437401178668,19.411022297013,511754.463553472,Inf,4.73122070382274,-4,6,0,0,6,0,0,0,0,0,0,2,-2,0,0,0,0,-5,0,-5,-1,0,0,0,2,-0.438956433637285,-0.592764857881137,0.040914852235229,-0.186018755328218,-0.486910994764398,0.705263157894737,-0.995881383855025,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","150/150","H",13.1456002256222,0.924803768447052,139.277183326685,0.0943844491368574,0.0001628371344425,NA,1.28804840845689,0.0292235860951597,1.53426649183163,0.91081598550184,Inf,0.0296198560706035,"lineage2","dr_mutations_pyrazinamide","GLN",0,"SAMN02360618","SRR1049072_SRR1013676_SRR1049073_SRR1013677","lineage2.2.1","kr","South Korea","pnca_p.his71gln","A","-","HIS","HA71","pnca_complex.pdb"
|
|
"H71Q","L4","PZA","H","H71",71,"Q",NA,"MDR","DM","hydrophobic","hydrophilic","basic","neutral","pos","polar",4.184,-1.733,-2.294,1.12335,-1.091,-1.86,67,80,-1.209,9,9,5,0.0223214285714285,"loop",-0.766666666666667,6.25,0.0001437401178668,19.411022297013,511754.463553472,Inf,4.73122070382274,-4,6,0,0,6,0,0,0,0,0,0,2,-2,0,0,0,0,-5,0,-5,-1,0,0,0,2,-0.438956433637285,-0.592764857881137,0.040914852235229,-0.186018755328218,-0.486910994764398,0.705263157894737,-0.995881383855025,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","150/150","H",13.1456002256222,0.924803768447052,139.277183326685,0.0943844491368574,0.0001628371344425,NA,1.28804840845689,0.0292235860951597,1.53426649183163,0.91081598550184,Inf,0.0296198560706035,"lineage4","dr_mutations_pyrazinamide","GLN",0,"ERR1035262","ERR1035262","lineage4.3.2","br","Brazil","pnca_p.his71gln","A","-","HIS","HA71","pnca_complex.pdb"
|
|
"H71Q","L2","PZA","H","H71",71,"Q",1,"Pre-XDR","DM","hydrophobic","hydrophilic","basic","neutral","pos","polar",4.184,-1.733,-2.294,1.12335,-1.091,-1.86,67,80,-1.209,9,9,5,0.0223214285714285,"loop",-0.766666666666667,6.25,0.0001437401178668,19.411022297013,511754.463553472,Inf,4.73122070382274,-4,6,0,0,6,0,0,0,0,0,0,2,-2,0,0,0,0,-5,0,-5,-1,0,0,0,2,-0.438956433637285,-0.592764857881137,0.040914852235229,-0.186018755328218,-0.486910994764398,0.705263157894737,-0.995881383855025,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","150/150","H",13.1456002256222,0.924803768447052,139.277183326685,0.0943844491368574,0.0001628371344425,NA,1.28804840845689,0.0292235860951597,1.53426649183163,0.91081598550184,Inf,0.0296198560706035,"lineage2","dr_mutations_pyrazinamide","GLN",0,"ERR144571,1852P-sc-2012-02-21T11:37:42Z-1364808","ERR144571","lineage2.2.1","ru","Russia,Samara","pnca_p.his71gln","A","-","HIS","HA71","pnca_complex.pdb"
|
|
"H71Q","L2","PZA","H","H71",71,"Q",1,"Pre-XDR","DM","hydrophobic","hydrophilic","basic","neutral","pos","polar",4.184,-1.733,-2.294,1.12335,-1.091,-1.86,67,80,-1.209,9,9,5,0.0223214285714285,"loop",-0.766666666666667,6.25,0.0001437401178668,19.411022297013,511754.463553472,Inf,4.73122070382274,-4,6,0,0,6,0,0,0,0,0,0,2,-2,0,0,0,0,-5,0,-5,-1,0,0,0,2,-0.438956433637285,-0.592764857881137,0.040914852235229,-0.186018755328218,-0.486910994764398,0.705263157894737,-0.995881383855025,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","150/150","H",13.1456002256222,0.924803768447052,139.277183326685,0.0943844491368574,0.0001628371344425,NA,1.28804840845689,0.0292235860951597,1.53426649183163,0.91081598550184,Inf,0.0296198560706035,"lineage2","dr_mutations_pyrazinamide","GLN",0,"ERS456913","ERR550838_ERR550837","lineage2.2.1","uz","Nukus","pnca_p.his71gln","A","-","HIS","HA71","pnca_complex.pdb"
|
|
"H71Q","L2","PZA","H","H71",71,"Q",NA,"Other","DM","hydrophobic","hydrophilic","basic","neutral","pos","polar",4.184,-1.733,-2.294,1.12335,-1.091,-1.86,67,80,-1.209,9,9,5,0.0223214285714285,"loop",-0.766666666666667,6.25,0.0001437401178668,19.411022297013,511754.463553472,Inf,4.73122070382274,-4,6,0,0,6,0,0,0,0,0,0,2,-2,0,0,0,0,-5,0,-5,-1,0,0,0,2,-0.438956433637285,-0.592764857881137,0.040914852235229,-0.186018755328218,-0.486910994764398,0.705263157894737,-0.995881383855025,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","150/150","H",13.1456002256222,0.924803768447052,139.277183326685,0.0943844491368574,0.0001628371344425,NA,1.28804840845689,0.0292235860951597,1.53426649183163,0.91081598550184,Inf,0.0296198560706035,"lineage2","dr_mutations_pyrazinamide","GLN",0,"ERR026477","ERR026477","lineage2.2.1","nl","Netherlands","pnca_p.his71gln","A","-","HIS","HA71","pnca_complex.pdb"
|
|
"H71Q","L2","PZA","H","H71",71,"Q",NA,"Other","DM","hydrophobic","hydrophilic","basic","neutral","pos","polar",4.184,-1.733,-2.294,1.12335,-1.091,-1.86,67,80,-1.209,9,9,5,0.0223214285714285,"loop",-0.766666666666667,6.25,0.0001437401178668,19.411022297013,511754.463553472,Inf,4.73122070382274,-4,6,0,0,6,0,0,0,0,0,0,2,-2,0,0,0,0,-5,0,-5,-1,0,0,0,2,-0.438956433637285,-0.592764857881137,0.040914852235229,-0.186018755328218,-0.486910994764398,0.705263157894737,-0.995881383855025,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","150/150","H",13.1456002256222,0.924803768447052,139.277183326685,0.0943844491368574,0.0001628371344425,NA,1.28804840845689,0.0292235860951597,1.53426649183163,0.91081598550184,Inf,0.0296198560706035,"lineage2","dr_mutations_pyrazinamide","GLN",0,"ERR029205","ERR029205","lineage2.2.1","nl","Netherlands","pnca_p.his71gln","A","-","HIS","HA71","pnca_complex.pdb"
|
|
"H71Q","L4","PZA","H","H71",71,"Q",NA,"MDR","DM","hydrophobic","hydrophilic","basic","neutral","pos","polar",4.184,-1.733,-2.294,1.12335,-1.091,-1.86,67,80,-1.209,9,9,5,0.0223214285714285,"loop",-0.766666666666667,6.25,0.0001437401178668,19.411022297013,511754.463553472,Inf,4.73122070382274,-4,6,0,0,6,0,0,0,0,0,0,2,-2,0,0,0,0,-5,0,-5,-1,0,0,0,2,-0.438956433637285,-0.592764857881137,0.040914852235229,-0.186018755328218,-0.486910994764398,0.705263157894737,-0.995881383855025,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","150/150","H",13.1456002256222,0.924803768447052,139.277183326685,0.0943844491368574,0.0001628371344425,NA,1.28804840845689,0.0292235860951597,1.53426649183163,0.91081598550184,Inf,0.0296198560706035,"lineage4","dr_mutations_pyrazinamide","GLN",0,"ERR1035334","ERR1035334","lineage4.3.2","br","Brazil","pnca_p.his71gln","A","-","HIS","HA71","pnca_complex.pdb"
|
|
"H71Q","L4","PZA","H","H71",71,"Q",NA,"MDR","DM","hydrophobic","hydrophilic","basic","neutral","pos","polar",4.184,-1.733,-2.294,1.12335,-1.091,-1.86,67,80,-1.209,9,9,5,0.0223214285714285,"loop",-0.766666666666667,6.25,0.0001437401178668,19.411022297013,511754.463553472,Inf,4.73122070382274,-4,6,0,0,6,0,0,0,0,0,0,2,-2,0,0,0,0,-5,0,-5,-1,0,0,0,2,-0.438956433637285,-0.592764857881137,0.040914852235229,-0.186018755328218,-0.486910994764398,0.705263157894737,-0.995881383855025,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","150/150","H",13.1456002256222,0.924803768447052,139.277183326685,0.0943844491368574,0.0001628371344425,NA,1.28804840845689,0.0292235860951597,1.53426649183163,0.91081598550184,Inf,0.0296198560706035,"lineage4","dr_mutations_pyrazinamide","GLN",0,"ERR1035316","ERR1035316","lineage4.3.2","br","Brazil","pnca_p.his71gln","A","-","HIS","HA71","pnca_complex.pdb"
|
|
"H71R","L4","PZA","H","H71",71,"R",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",4.184,-0.831,-1.93,-1.52387,-1.26,-1.58,77,85,-1.209,9,9,5,0.0223214285714285,"loop",-0.766666666666667,6.25,0.0005030904125341,1.94026083298275,1.94026661170037,1.94003614333864,0.0926662555126122,-36,-2,0,0,-2,0,0,0,0,0,0,2,-2,0,0,0,0,-1,0,-1,1,-4,0,-4,0,-0.21048632218845,-0.498708010335917,-0.292984311312774,-0.214833759590793,-0.413612565445026,0.810526315789474,-0.995881383855025,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","150/150","H",0.662825392344309,0.428026066477985,0.836294653807202,0.792573992105318,0.27776402289494,9.00753289954653,0.287860116894481,0.342335895194644,0.465547561079344,0.184637933513187,11.8604663966297,0.760814539944039,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERR3335745","ERR3335745","lineage4.5","pk","Pakistan","pnca_p.his71arg","A","-","HIS","HA71","pnca_complex.pdb"
|
|
"H71R","L4","PZA","H","H71",71,"R",NA,"XDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",4.184,-0.831,-1.93,-1.52387,-1.26,-1.58,77,85,-1.209,9,9,5,0.0223214285714285,"loop",-0.766666666666667,6.25,0.0005030904125341,1.94026083298275,1.94026661170037,1.94003614333864,0.0926662555126122,-36,-2,0,0,-2,0,0,0,0,0,0,2,-2,0,0,0,0,-1,0,-1,1,-4,0,-4,0,-0.21048632218845,-0.498708010335917,-0.292984311312774,-0.214833759590793,-0.413612565445026,0.810526315789474,-0.995881383855025,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","150/150","H",0.662825392344309,0.428026066477985,0.836294653807202,0.792573992105318,0.27776402289494,9.00753289954653,0.287860116894481,0.342335895194644,0.465547561079344,0.184637933513187,11.8604663966297,0.760814539944039,"lineage4","dr_mutations_pyrazinamide","ARG",0,"SRR5266543","SRR5266543","lineage4.3.3","ru","Russia","pnca_p.his71arg","A","-","HIS","HA71","pnca_complex.pdb"
|
|
"H71R","L4","PZA","H","H71",71,"R",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",4.184,-0.831,-1.93,-1.52387,-1.26,-1.58,77,85,-1.209,9,9,5,0.0223214285714285,"loop",-0.766666666666667,6.25,0.0005030904125341,1.94026083298275,1.94026661170037,1.94003614333864,0.0926662555126122,-36,-2,0,0,-2,0,0,0,0,0,0,2,-2,0,0,0,0,-1,0,-1,1,-4,0,-4,0,-0.21048632218845,-0.498708010335917,-0.292984311312774,-0.214833759590793,-0.413612565445026,0.810526315789474,-0.995881383855025,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","150/150","H",0.662825392344309,0.428026066477985,0.836294653807202,0.792573992105318,0.27776402289494,9.00753289954653,0.287860116894481,0.342335895194644,0.465547561079344,0.184637933513187,11.8604663966297,0.760814539944039,"lineage4","dr_mutations_pyrazinamide","ARG",0,"SRR5710017,SAMN07236284","SRR5710017","lineage4.2.1","th","Thailand","pnca_p.his71arg","A","-","HIS","HA71","pnca_complex.pdb"
|
|
"H71R","L2","PZA","H","H71",71,"R",0,"Pre-XDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",4.184,-0.831,-1.93,-1.52387,-1.26,-1.58,77,85,-1.209,9,9,5,0.0223214285714285,"loop",-0.766666666666667,6.25,0.0005030904125341,1.94026083298275,1.94026661170037,1.94003614333864,0.0926662555126122,-36,-2,0,0,-2,0,0,0,0,0,0,2,-2,0,0,0,0,-1,0,-1,1,-4,0,-4,0,-0.21048632218845,-0.498708010335917,-0.292984311312774,-0.214833759590793,-0.413612565445026,0.810526315789474,-0.995881383855025,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","150/150","H",0.662825392344309,0.428026066477985,0.836294653807202,0.792573992105318,0.27776402289494,9.00753289954653,0.287860116894481,0.342335895194644,0.465547561079344,0.184637933513187,11.8604663966297,0.760814539944039,"lineage2","dr_mutations_pyrazinamide","ARG",0,"ERR2516203","ERR2516203","lineage2.2.1","be","Belgium","pnca_p.his71arg","A","-","HIS","HA71","pnca_complex.pdb"
|
|
"H71R","L4","PZA","H","H71",71,"R",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",4.184,-0.831,-1.93,-1.52387,-1.26,-1.58,77,85,-1.209,9,9,5,0.0223214285714285,"loop",-0.766666666666667,6.25,0.0005030904125341,1.94026083298275,1.94026661170037,1.94003614333864,0.0926662555126122,-36,-2,0,0,-2,0,0,0,0,0,0,2,-2,0,0,0,0,-1,0,-1,1,-4,0,-4,0,-0.21048632218845,-0.498708010335917,-0.292984311312774,-0.214833759590793,-0.413612565445026,0.810526315789474,-0.995881383855025,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","150/150","H",0.662825392344309,0.428026066477985,0.836294653807202,0.792573992105318,0.27776402289494,9.00753289954653,0.287860116894481,0.342335895194644,0.465547561079344,0.184637933513187,11.8604663966297,0.760814539944039,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERR3335744","ERR3335744","lineage4.5","pk","Pakistan","pnca_p.his71arg","A","-","HIS","HA71","pnca_complex.pdb"
|
|
"H71R","L2","PZA","H","H71",71,"R",1,"Pre-XDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",4.184,-0.831,-1.93,-1.52387,-1.26,-1.58,77,85,-1.209,9,9,5,0.0223214285714285,"loop",-0.766666666666667,6.25,0.0005030904125341,1.94026083298275,1.94026661170037,1.94003614333864,0.0926662555126122,-36,-2,0,0,-2,0,0,0,0,0,0,2,-2,0,0,0,0,-1,0,-1,1,-4,0,-4,0,-0.21048632218845,-0.498708010335917,-0.292984311312774,-0.214833759590793,-0.413612565445026,0.810526315789474,-0.995881383855025,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","150/150","H",0.662825392344309,0.428026066477985,0.836294653807202,0.792573992105318,0.27776402289494,9.00753289954653,0.287860116894481,0.342335895194644,0.465547561079344,0.184637933513187,11.8604663966297,0.760814539944039,"lineage2","dr_mutations_pyrazinamide","ARG",0,"ERR2516345","ERR2516345","lineage2.2.1","be","Belgium","pnca_p.his71arg","A","-","HIS","HA71","pnca_complex.pdb"
|
|
"H71R","L4","PZA","H","H71",71,"R",NA,"MDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",4.184,-0.831,-1.93,-1.52387,-1.26,-1.58,77,85,-1.209,9,9,5,0.0223214285714285,"loop",-0.766666666666667,6.25,0.0005030904125341,1.94026083298275,1.94026661170037,1.94003614333864,0.0926662555126122,-36,-2,0,0,-2,0,0,0,0,0,0,2,-2,0,0,0,0,-1,0,-1,1,-4,0,-4,0,-0.21048632218845,-0.498708010335917,-0.292984311312774,-0.214833759590793,-0.413612565445026,0.810526315789474,-0.995881383855025,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","150/150","H",0.662825392344309,0.428026066477985,0.836294653807202,0.792573992105318,0.27776402289494,9.00753289954653,0.287860116894481,0.342335895194644,0.465547561079344,0.184637933513187,11.8604663966297,0.760814539944039,"lineage4","dr_mutations_pyrazinamide","ARG",0,"SRR3724951","SRR3724951","lineage4.3.2","cd","DRC","pnca_p.his71arg","A","-","HIS","HA71","pnca_complex.pdb"
|
|
"H71R","L4","PZA","H","H71",71,"R",NA,"MDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",4.184,-0.831,-1.93,-1.52387,-1.26,-1.58,77,85,-1.209,9,9,5,0.0223214285714285,"loop",-0.766666666666667,6.25,0.0005030904125341,1.94026083298275,1.94026661170037,1.94003614333864,0.0926662555126122,-36,-2,0,0,-2,0,0,0,0,0,0,2,-2,0,0,0,0,-1,0,-1,1,-4,0,-4,0,-0.21048632218845,-0.498708010335917,-0.292984311312774,-0.214833759590793,-0.413612565445026,0.810526315789474,-0.995881383855025,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","150/150","H",0.662825392344309,0.428026066477985,0.836294653807202,0.792573992105318,0.27776402289494,9.00753289954653,0.287860116894481,0.342335895194644,0.465547561079344,0.184637933513187,11.8604663966297,0.760814539944039,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERR775372","ERR775372","lineage4.3.3","pe","","pnca_p.his71arg","A","-","HIS","HA71","pnca_complex.pdb"
|
|
"H71R","L2","PZA","H","H71",71,"R",0,"Pre-XDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",4.184,-0.831,-1.93,-1.52387,-1.26,-1.58,77,85,-1.209,9,9,5,0.0223214285714285,"loop",-0.766666666666667,6.25,0.0005030904125341,1.94026083298275,1.94026661170037,1.94003614333864,0.0926662555126122,-36,-2,0,0,-2,0,0,0,0,0,0,2,-2,0,0,0,0,-1,0,-1,1,-4,0,-4,0,-0.21048632218845,-0.498708010335917,-0.292984311312774,-0.214833759590793,-0.413612565445026,0.810526315789474,-0.995881383855025,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","150/150","H",0.662825392344309,0.428026066477985,0.836294653807202,0.792573992105318,0.27776402289494,9.00753289954653,0.287860116894481,0.342335895194644,0.465547561079344,0.184637933513187,11.8604663966297,0.760814539944039,"lineage2","dr_mutations_pyrazinamide","ARG",0,"2150N-sc-2012-04-10T09:16:26Z-1397808,ERR158596","ERR158596","lineage2.2.1","ru","Russia,Samara","pnca_p.his71arg","A","-","HIS","HA71","pnca_complex.pdb"
|
|
"H71R","L2","PZA","H","H71",71,"R",NA,"MDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",4.184,-0.831,-1.93,-1.52387,-1.26,-1.58,77,85,-1.209,9,9,5,0.0223214285714285,"loop",-0.766666666666667,6.25,0.0005030904125341,1.94026083298275,1.94026661170037,1.94003614333864,0.0926662555126122,-36,-2,0,0,-2,0,0,0,0,0,0,2,-2,0,0,0,0,-1,0,-1,1,-4,0,-4,0,-0.21048632218845,-0.498708010335917,-0.292984311312774,-0.214833759590793,-0.413612565445026,0.810526315789474,-0.995881383855025,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","150/150","H",0.662825392344309,0.428026066477985,0.836294653807202,0.792573992105318,0.27776402289494,9.00753289954653,0.287860116894481,0.342335895194644,0.465547561079344,0.184637933513187,11.8604663966297,0.760814539944039,"lineage2","dr_mutations_pyrazinamide","ARG",0,"ERR751378","ERR751378","lineage2.2.1","pe","","pnca_p.his71arg","A","-","HIS","HA71","pnca_complex.pdb"
|
|
"H71R","L4","PZA","H","H71",71,"R",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",4.184,-0.831,-1.93,-1.52387,-1.26,-1.58,77,85,-1.209,9,9,5,0.0223214285714285,"loop",-0.766666666666667,6.25,0.0005030904125341,1.94026083298275,1.94026661170037,1.94003614333864,0.0926662555126122,-36,-2,0,0,-2,0,0,0,0,0,0,2,-2,0,0,0,0,-1,0,-1,1,-4,0,-4,0,-0.21048632218845,-0.498708010335917,-0.292984311312774,-0.214833759590793,-0.413612565445026,0.810526315789474,-0.995881383855025,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","150/150","H",0.662825392344309,0.428026066477985,0.836294653807202,0.792573992105318,0.27776402289494,9.00753289954653,0.287860116894481,0.342335895194644,0.465547561079344,0.184637933513187,11.8604663966297,0.760814539944039,"lineage4","dr_mutations_pyrazinamide","ARG",0,"SRR5709752,SAMN07236277","SRR5709752","lineage4.2.1","th","Thailand","pnca_p.his71arg","A","-","HIS","HA71","pnca_complex.pdb"
|
|
"H71R","L4","PZA","H","H71",71,"R",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",4.184,-0.831,-1.93,-1.52387,-1.26,-1.58,77,85,-1.209,9,9,5,0.0223214285714285,"loop",-0.766666666666667,6.25,0.0005030904125341,1.94026083298275,1.94026661170037,1.94003614333864,0.0926662555126122,-36,-2,0,0,-2,0,0,0,0,0,0,2,-2,0,0,0,0,-1,0,-1,1,-4,0,-4,0,-0.21048632218845,-0.498708010335917,-0.292984311312774,-0.214833759590793,-0.413612565445026,0.810526315789474,-0.995881383855025,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","150/150","H",0.662825392344309,0.428026066477985,0.836294653807202,0.792573992105318,0.27776402289494,9.00753289954653,0.287860116894481,0.342335895194644,0.465547561079344,0.184637933513187,11.8604663966297,0.760814539944039,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERR3335733","ERR3335733","lineage4.5","pk","Pakistan","pnca_p.his71arg","A","-","HIS","HA71","pnca_complex.pdb"
|
|
"H71R","L4","PZA","H","H71",71,"R",0,"MDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",4.184,-0.831,-1.93,-1.52387,-1.26,-1.58,77,85,-1.209,9,9,5,0.0223214285714285,"loop",-0.766666666666667,6.25,0.0005030904125341,1.94026083298275,1.94026661170037,1.94003614333864,0.0926662555126122,-36,-2,0,0,-2,0,0,0,0,0,0,2,-2,0,0,0,0,-1,0,-1,1,-4,0,-4,0,-0.21048632218845,-0.498708010335917,-0.292984311312774,-0.214833759590793,-0.413612565445026,0.810526315789474,-0.995881383855025,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","150/150","H",0.662825392344309,0.428026066477985,0.836294653807202,0.792573992105318,0.27776402289494,9.00753289954653,0.287860116894481,0.342335895194644,0.465547561079344,0.184637933513187,11.8604663966297,0.760814539944039,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERR040134","ERR040134","lineage4.3.4.2.1","ug","Uganda","pnca_p.his71arg","A","-","HIS","HA71","pnca_complex.pdb"
|
|
"H71R","L2","PZA","H","H71",71,"R",0,"Pre-XDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",4.184,-0.831,-1.93,-1.52387,-1.26,-1.58,77,85,-1.209,9,9,5,0.0223214285714285,"loop",-0.766666666666667,6.25,0.0005030904125341,1.94026083298275,1.94026661170037,1.94003614333864,0.0926662555126122,-36,-2,0,0,-2,0,0,0,0,0,0,2,-2,0,0,0,0,-1,0,-1,1,-4,0,-4,0,-0.21048632218845,-0.498708010335917,-0.292984311312774,-0.214833759590793,-0.413612565445026,0.810526315789474,-0.995881383855025,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","150/150","H",0.662825392344309,0.428026066477985,0.836294653807202,0.792573992105318,0.27776402289494,9.00753289954653,0.287860116894481,0.342335895194644,0.465547561079344,0.184637933513187,11.8604663966297,0.760814539944039,"lineage2","dr_mutations_pyrazinamide","ARG",0,"2485C-sc-2012-10-11T13:39:47Z-1494287,ERR229968","ERR229968","lineage2.2.1","ru","Russia,Samara","pnca_p.his71arg","A","-","HIS","HA71","pnca_complex.pdb"
|
|
"H71R","L2","PZA","H","H71",71,"R",1,"Pre-XDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",4.184,-0.831,-1.93,-1.52387,-1.26,-1.58,77,85,-1.209,9,9,5,0.0223214285714285,"loop",-0.766666666666667,6.25,0.0005030904125341,1.94026083298275,1.94026661170037,1.94003614333864,0.0926662555126122,-36,-2,0,0,-2,0,0,0,0,0,0,2,-2,0,0,0,0,-1,0,-1,1,-4,0,-4,0,-0.21048632218845,-0.498708010335917,-0.292984311312774,-0.214833759590793,-0.413612565445026,0.810526315789474,-0.995881383855025,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","150/150","H",0.662825392344309,0.428026066477985,0.836294653807202,0.792573992105318,0.27776402289494,9.00753289954653,0.287860116894481,0.342335895194644,0.465547561079344,0.184637933513187,11.8604663966297,0.760814539944039,"lineage2","dr_mutations_pyrazinamide","ARG",0,"1422X-sc-2012-02-21T11:36:40Z-1364721,ERR137229","ERR137229","lineage2.2.1","ru","Russia,Samara","pnca_p.his71arg","A","-","HIS","HA71","pnca_complex.pdb"
|
|
"H71R","L4","PZA","H","H71",71,"R",NA,"MDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",4.184,-0.831,-1.93,-1.52387,-1.26,-1.58,77,85,-1.209,9,9,5,0.0223214285714285,"loop",-0.766666666666667,6.25,0.0005030904125341,1.94026083298275,1.94026661170037,1.94003614333864,0.0926662555126122,-36,-2,0,0,-2,0,0,0,0,0,0,2,-2,0,0,0,0,-1,0,-1,1,-4,0,-4,0,-0.21048632218845,-0.498708010335917,-0.292984311312774,-0.214833759590793,-0.413612565445026,0.810526315789474,-0.995881383855025,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","150/150","H",0.662825392344309,0.428026066477985,0.836294653807202,0.792573992105318,0.27776402289494,9.00753289954653,0.287860116894481,0.342335895194644,0.465547561079344,0.184637933513187,11.8604663966297,0.760814539944039,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERR2707046","ERR2707046","lineage4.3.2","cd","Democratic Republic of Congo","pnca_p.his71arg","A","-","HIS","HA71","pnca_complex.pdb"
|
|
"H71R","L2","PZA","H","H71",71,"R",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",4.184,-0.831,-1.93,-1.52387,-1.26,-1.58,77,85,-1.209,9,9,5,0.0223214285714285,"loop",-0.766666666666667,6.25,0.0005030904125341,1.94026083298275,1.94026661170037,1.94003614333864,0.0926662555126122,-36,-2,0,0,-2,0,0,0,0,0,0,2,-2,0,0,0,0,-1,0,-1,1,-4,0,-4,0,-0.21048632218845,-0.498708010335917,-0.292984311312774,-0.214833759590793,-0.413612565445026,0.810526315789474,-0.995881383855025,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","150/150","H",0.662825392344309,0.428026066477985,0.836294653807202,0.792573992105318,0.27776402289494,9.00753289954653,0.287860116894481,0.342335895194644,0.465547561079344,0.184637933513187,11.8604663966297,0.760814539944039,"lineage2","dr_mutations_pyrazinamide","ARG",0,"ERR144601","ERR144601","lineage2.2.1","ru","Russia","pnca_p.his71arg","A","-","HIS","HA71","pnca_complex.pdb"
|
|
"H71R","L2","PZA","H","H71",71,"R",NA,"MDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",4.184,-0.831,-1.93,-1.52387,-1.26,-1.58,77,85,-1.209,9,9,5,0.0223214285714285,"loop",-0.766666666666667,6.25,0.0005030904125341,1.94026083298275,1.94026661170037,1.94003614333864,0.0926662555126122,-36,-2,0,0,-2,0,0,0,0,0,0,2,-2,0,0,0,0,-1,0,-1,1,-4,0,-4,0,-0.21048632218845,-0.498708010335917,-0.292984311312774,-0.214833759590793,-0.413612565445026,0.810526315789474,-0.995881383855025,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","150/150","H",0.662825392344309,0.428026066477985,0.836294653807202,0.792573992105318,0.27776402289494,9.00753289954653,0.287860116894481,0.342335895194644,0.465547561079344,0.184637933513187,11.8604663966297,0.760814539944039,"lineage2","dr_mutations_pyrazinamide","ARG",0,"1811V-sc-2012-02-21T11:37:29Z-1364791,ERR144554","ERR144554","lineage2.2.1","ru","Russia","pnca_p.his71arg","A","-","HIS","HA71","pnca_complex.pdb"
|
|
"H71R","L2;L4","PZA","H","H71",71,"R",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",4.184,-0.831,-1.93,-1.52387,-1.26,-1.58,77,85,-1.209,9,9,5,0.0223214285714285,"loop",-0.766666666666667,6.25,0.0005030904125341,1.94026083298275,1.94026661170037,1.94003614333864,0.0926662555126122,-36,-2,0,0,-2,0,0,0,0,0,0,2,-2,0,0,0,0,-1,0,-1,1,-4,0,-4,0,-0.21048632218845,-0.498708010335917,-0.292984311312774,-0.214833759590793,-0.413612565445026,0.810526315789474,-0.995881383855025,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","150/150","H",0.662825392344309,0.428026066477985,0.836294653807202,0.792573992105318,0.27776402289494,9.00753289954653,0.287860116894481,0.342335895194644,0.465547561079344,0.184637933513187,11.8604663966297,0.760814539944039,"lineage2;lineage4","dr_mutations_pyrazinamide","ARG",0,"ERR234643,1377Y-sc-2012-10-11T13:37:15Z-1494129","ERR234643","lineage4;lineage2.2.1","ru","Russia","pnca_p.his71arg","A","-","HIS","HA71","pnca_complex.pdb"
|
|
"H71R","L2","PZA","H","H71",71,"R",0,"Pre-XDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",4.184,-0.831,-1.93,-1.52387,-1.26,-1.58,77,85,-1.209,9,9,5,0.0223214285714285,"loop",-0.766666666666667,6.25,0.0005030904125341,1.94026083298275,1.94026661170037,1.94003614333864,0.0926662555126122,-36,-2,0,0,-2,0,0,0,0,0,0,2,-2,0,0,0,0,-1,0,-1,1,-4,0,-4,0,-0.21048632218845,-0.498708010335917,-0.292984311312774,-0.214833759590793,-0.413612565445026,0.810526315789474,-0.995881383855025,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","150/150","H",0.662825392344309,0.428026066477985,0.836294653807202,0.792573992105318,0.27776402289494,9.00753289954653,0.287860116894481,0.342335895194644,0.465547561079344,0.184637933513187,11.8604663966297,0.760814539944039,"lineage2","dr_mutations_pyrazinamide","ARG",0,"1709J-sc-2012-02-21T11:37:04Z-1364756,ERR137264","ERR137264","lineage2.2.1","ru","Russia,Samara","pnca_p.his71arg","A","-","HIS","HA71","pnca_complex.pdb"
|
|
"H71R","L2","PZA","H","H71",71,"R",NA,"MDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",4.184,-0.831,-1.93,-1.52387,-1.26,-1.58,77,85,-1.209,9,9,5,0.0223214285714285,"loop",-0.766666666666667,6.25,0.0005030904125341,1.94026083298275,1.94026661170037,1.94003614333864,0.0926662555126122,-36,-2,0,0,-2,0,0,0,0,0,0,2,-2,0,0,0,0,-1,0,-1,1,-4,0,-4,0,-0.21048632218845,-0.498708010335917,-0.292984311312774,-0.214833759590793,-0.413612565445026,0.810526315789474,-0.995881383855025,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","150/150","H",0.662825392344309,0.428026066477985,0.836294653807202,0.792573992105318,0.27776402289494,9.00753289954653,0.287860116894481,0.342335895194644,0.465547561079344,0.184637933513187,11.8604663966297,0.760814539944039,"lineage2","dr_mutations_pyrazinamide","ARG",0,"SRS935936,SAMN03653210","SRR2024881","lineage2.2.1","cn","China","pnca_p.his71arg","A","-","HIS","HA71","pnca_complex.pdb"
|
|
"H71Y","L4","PZA","H","H71",71,"Y",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","basic","neutral","pos","polar",4.184,-1.955,-0.461,-1.77532,-0.84,-0.23,61,80,-1.209,9,9,5,0.0223214285714285,"loop",-0.766666666666667,6.25,0.0017967514733362,25.6733460559796,25.6733459339263,25.6638623299459,74.4270249019608,-26,-6,0,0,-6,0,0,0,0,-2,0,2,-4,0,0,0,0,-8,0,-3,-5,-12,0,-12,-6,-0.495187436676798,-0.119121447028424,-0.34132892409444,-0.143222506393862,-0.0602094240837696,0.642105263157895,-0.995881383855025,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","150/150","H",3.24545333052325,2.7826871320661e-09,0.546011377839736,5.94392985612077,9.76352440503871,88.06998811648,1.40948247478545,4.51976315688199e-13,12.3448843223466,8.64707452935555,102.96388402837,6.29217184975434e-18,"lineage4","dr_mutations_pyrazinamide","TYR",0,"ERR2516045","ERR2516045","lineage4.1.2.1","za","South Africa","pnca_p.his71tyr","A","-","HIS","HA71","pnca_complex.pdb"
|
|
"H71Y","L4","PZA","H","H71",71,"Y",1,"Pre-XDR","DM","hydrophobic","hydrophobic","basic","neutral","pos","polar",4.184,-1.955,-0.461,-1.77532,-0.84,-0.23,61,80,-1.209,9,9,5,0.0223214285714285,"loop",-0.766666666666667,6.25,0.0017967514733362,25.6733460559796,25.6733459339263,25.6638623299459,74.4270249019608,-26,-6,0,0,-6,0,0,0,0,-2,0,2,-4,0,0,0,0,-8,0,-3,-5,-12,0,-12,-6,-0.495187436676798,-0.119121447028424,-0.34132892409444,-0.143222506393862,-0.0602094240837696,0.642105263157895,-0.995881383855025,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","150/150","H",3.24545333052325,2.7826871320661e-09,0.546011377839736,5.94392985612077,9.76352440503871,88.06998811648,1.40948247478545,4.51976315688199e-13,12.3448843223466,8.64707452935555,102.96388402837,6.29217184975434e-18,"lineage4","dr_mutations_pyrazinamide","TYR",0,"SAMN03648821,SRR2101574","SRR2101574","lineage4.1.2.1","","","pnca_p.his71tyr","A","-","HIS","HA71","pnca_complex.pdb"
|
|
"H71Y","L4","PZA","H","H71",71,"Y",1,"MDR","DM","hydrophobic","hydrophobic","basic","neutral","pos","polar",4.184,-1.955,-0.461,-1.77532,-0.84,-0.23,61,80,-1.209,9,9,5,0.0223214285714285,"loop",-0.766666666666667,6.25,0.0017967514733362,25.6733460559796,25.6733459339263,25.6638623299459,74.4270249019608,-26,-6,0,0,-6,0,0,0,0,-2,0,2,-4,0,0,0,0,-8,0,-3,-5,-12,0,-12,-6,-0.495187436676798,-0.119121447028424,-0.34132892409444,-0.143222506393862,-0.0602094240837696,0.642105263157895,-0.995881383855025,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","150/150","H",3.24545333052325,2.7826871320661e-09,0.546011377839736,5.94392985612077,9.76352440503871,88.06998811648,1.40948247478545,4.51976315688199e-13,12.3448843223466,8.64707452935555,102.96388402837,6.29217184975434e-18,"lineage4","dr_mutations_pyrazinamide","TYR",0,"ERR2516939","ERR2516939","lineage4.5","gb","UK","pnca_p.his71tyr","A","-","HIS","HA71","pnca_complex.pdb"
|
|
"H71Y","L2","PZA","H","H71",71,"Y",0,"MDR","DM","hydrophobic","hydrophobic","basic","neutral","pos","polar",4.184,-1.955,-0.461,-1.77532,-0.84,-0.23,61,80,-1.209,9,9,5,0.0223214285714285,"loop",-0.766666666666667,6.25,0.0017967514733362,25.6733460559796,25.6733459339263,25.6638623299459,74.4270249019608,-26,-6,0,0,-6,0,0,0,0,-2,0,2,-4,0,0,0,0,-8,0,-3,-5,-12,0,-12,-6,-0.495187436676798,-0.119121447028424,-0.34132892409444,-0.143222506393862,-0.0602094240837696,0.642105263157895,-0.995881383855025,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","150/150","H",3.24545333052325,2.7826871320661e-09,0.546011377839736,5.94392985612077,9.76352440503871,88.06998811648,1.40948247478545,4.51976315688199e-13,12.3448843223466,8.64707452935555,102.96388402837,6.29217184975434e-18,"lineage2","dr_mutations_pyrazinamide","TYR",0,"ERR2516953","ERR2516953","lineage2.2.1","gb","UK","pnca_p.his71tyr","A","-","HIS","HA71","pnca_complex.pdb"
|
|
"H71Y","L4","PZA","H","H71",71,"Y",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","basic","neutral","pos","polar",4.184,-1.955,-0.461,-1.77532,-0.84,-0.23,61,80,-1.209,9,9,5,0.0223214285714285,"loop",-0.766666666666667,6.25,0.0017967514733362,25.6733460559796,25.6733459339263,25.6638623299459,74.4270249019608,-26,-6,0,0,-6,0,0,0,0,-2,0,2,-4,0,0,0,0,-8,0,-3,-5,-12,0,-12,-6,-0.495187436676798,-0.119121447028424,-0.34132892409444,-0.143222506393862,-0.0602094240837696,0.642105263157895,-0.995881383855025,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","150/150","H",3.24545333052325,2.7826871320661e-09,0.546011377839736,5.94392985612077,9.76352440503871,88.06998811648,1.40948247478545,4.51976315688199e-13,12.3448843223466,8.64707452935555,102.96388402837,6.29217184975434e-18,"lineage4","dr_mutations_pyrazinamide","TYR",0,"ERR2515588","ERR2515588","lineage4.1.2.1","za","South Africa","pnca_p.his71tyr","A","-","HIS","HA71","pnca_complex.pdb"
|
|
"H71Y","L4","PZA","H","H71",71,"Y",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","basic","neutral","pos","polar",4.184,-1.955,-0.461,-1.77532,-0.84,-0.23,61,80,-1.209,9,9,5,0.0223214285714285,"loop",-0.766666666666667,6.25,0.0017967514733362,25.6733460559796,25.6733459339263,25.6638623299459,74.4270249019608,-26,-6,0,0,-6,0,0,0,0,-2,0,2,-4,0,0,0,0,-8,0,-3,-5,-12,0,-12,-6,-0.495187436676798,-0.119121447028424,-0.34132892409444,-0.143222506393862,-0.0602094240837696,0.642105263157895,-0.995881383855025,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","150/150","H",3.24545333052325,2.7826871320661e-09,0.546011377839736,5.94392985612077,9.76352440503871,88.06998811648,1.40948247478545,4.51976315688199e-13,12.3448843223466,8.64707452935555,102.96388402837,6.29217184975434e-18,"lineage4","dr_mutations_pyrazinamide","TYR",0,"ERR2515667","ERR2515667","lineage4.1.2.1","za","South Africa","pnca_p.his71tyr","A","-","HIS","HA71","pnca_complex.pdb"
|
|
"H71Y","L4","PZA","H","H71",71,"Y",NA,"MDR","DM","hydrophobic","hydrophobic","basic","neutral","pos","polar",4.184,-1.955,-0.461,-1.77532,-0.84,-0.23,61,80,-1.209,9,9,5,0.0223214285714285,"loop",-0.766666666666667,6.25,0.0017967514733362,25.6733460559796,25.6733459339263,25.6638623299459,74.4270249019608,-26,-6,0,0,-6,0,0,0,0,-2,0,2,-4,0,0,0,0,-8,0,-3,-5,-12,0,-12,-6,-0.495187436676798,-0.119121447028424,-0.34132892409444,-0.143222506393862,-0.0602094240837696,0.642105263157895,-0.995881383855025,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","150/150","H",3.24545333052325,2.7826871320661e-09,0.546011377839736,5.94392985612077,9.76352440503871,88.06998811648,1.40948247478545,4.51976315688199e-13,12.3448843223466,8.64707452935555,102.96388402837,6.29217184975434e-18,"lineage4","dr_mutations_pyrazinamide","TYR",0,"SAMN02053783","SRR833194_SRR833075","lineage4.1.2.1","za","South Africa","pnca_p.his71tyr","A","-","HIS","HA71","pnca_complex.pdb"
|
|
"H71Y","L4","PZA","H","H71",71,"Y",NA,"MDR","DM","hydrophobic","hydrophobic","basic","neutral","pos","polar",4.184,-1.955,-0.461,-1.77532,-0.84,-0.23,61,80,-1.209,9,9,5,0.0223214285714285,"loop",-0.766666666666667,6.25,0.0017967514733362,25.6733460559796,25.6733459339263,25.6638623299459,74.4270249019608,-26,-6,0,0,-6,0,0,0,0,-2,0,2,-4,0,0,0,0,-8,0,-3,-5,-12,0,-12,-6,-0.495187436676798,-0.119121447028424,-0.34132892409444,-0.143222506393862,-0.0602094240837696,0.642105263157895,-0.995881383855025,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","150/150","H",3.24545333052325,2.7826871320661e-09,0.546011377839736,5.94392985612077,9.76352440503871,88.06998811648,1.40948247478545,4.51976315688199e-13,12.3448843223466,8.64707452935555,102.96388402837,6.29217184975434e-18,"lineage4","dr_mutations_pyrazinamide","TYR",0,"SRR4034388","SRR4034388","lineage4.1.2.1","za","South Africa: Kwazulu-Natal","pnca_p.his71tyr","A","-","HIS","HA71","pnca_complex.pdb"
|
|
"H71Y","L2","PZA","H","H71",71,"Y",NA,"MDR","DM","hydrophobic","hydrophobic","basic","neutral","pos","polar",4.184,-1.955,-0.461,-1.77532,-0.84,-0.23,61,80,-1.209,9,9,5,0.0223214285714285,"loop",-0.766666666666667,6.25,0.0017967514733362,25.6733460559796,25.6733459339263,25.6638623299459,74.4270249019608,-26,-6,0,0,-6,0,0,0,0,-2,0,2,-4,0,0,0,0,-8,0,-3,-5,-12,0,-12,-6,-0.495187436676798,-0.119121447028424,-0.34132892409444,-0.143222506393862,-0.0602094240837696,0.642105263157895,-0.995881383855025,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","150/150","H",3.24545333052325,2.7826871320661e-09,0.546011377839736,5.94392985612077,9.76352440503871,88.06998811648,1.40948247478545,4.51976315688199e-13,12.3448843223466,8.64707452935555,102.96388402837,6.29217184975434e-18,"lineage2","dr_mutations_pyrazinamide","TYR",0,"SAMN02584653","SRR1166267_SRR1169111","lineage2.2.1","md","Moldova","pnca_p.his71tyr","A","-","HIS","HA71","pnca_complex.pdb"
|
|
"H71Y","L4","PZA","H","H71",71,"Y",1,"MDR","DM","hydrophobic","hydrophobic","basic","neutral","pos","polar",4.184,-1.955,-0.461,-1.77532,-0.84,-0.23,61,80,-1.209,9,9,5,0.0223214285714285,"loop",-0.766666666666667,6.25,0.0017967514733362,25.6733460559796,25.6733459339263,25.6638623299459,74.4270249019608,-26,-6,0,0,-6,0,0,0,0,-2,0,2,-4,0,0,0,0,-8,0,-3,-5,-12,0,-12,-6,-0.495187436676798,-0.119121447028424,-0.34132892409444,-0.143222506393862,-0.0602094240837696,0.642105263157895,-0.995881383855025,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","150/150","H",3.24545333052325,2.7826871320661e-09,0.546011377839736,5.94392985612077,9.76352440503871,88.06998811648,1.40948247478545,4.51976315688199e-13,12.3448843223466,8.64707452935555,102.96388402837,6.29217184975434e-18,"lineage4","dr_mutations_pyrazinamide","TYR",0,"ERR2510312","ERR2510312","lineage4.5","pk","Pakistan","pnca_p.his71tyr","A","-","HIS","HA71","pnca_complex.pdb"
|
|
"H71Y","L4","PZA","H","H71",71,"Y",1,"MDR","DM","hydrophobic","hydrophobic","basic","neutral","pos","polar",4.184,-1.955,-0.461,-1.77532,-0.84,-0.23,61,80,-1.209,9,9,5,0.0223214285714285,"loop",-0.766666666666667,6.25,0.0017967514733362,25.6733460559796,25.6733459339263,25.6638623299459,74.4270249019608,-26,-6,0,0,-6,0,0,0,0,-2,0,2,-4,0,0,0,0,-8,0,-3,-5,-12,0,-12,-6,-0.495187436676798,-0.119121447028424,-0.34132892409444,-0.143222506393862,-0.0602094240837696,0.642105263157895,-0.995881383855025,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","150/150","H",3.24545333052325,2.7826871320661e-09,0.546011377839736,5.94392985612077,9.76352440503871,88.06998811648,1.40948247478545,4.51976315688199e-13,12.3448843223466,8.64707452935555,102.96388402837,6.29217184975434e-18,"lineage4","dr_mutations_pyrazinamide","TYR",0,"ERR2516166","ERR2516166","lineage4.8","be","Belgium","pnca_p.his71tyr","A","-","HIS","HA71","pnca_complex.pdb"
|
|
"H71Y","L4","PZA","H","H71",71,"Y",NA,"MDR","DM","hydrophobic","hydrophobic","basic","neutral","pos","polar",4.184,-1.955,-0.461,-1.77532,-0.84,-0.23,61,80,-1.209,9,9,5,0.0223214285714285,"loop",-0.766666666666667,6.25,0.0017967514733362,25.6733460559796,25.6733459339263,25.6638623299459,74.4270249019608,-26,-6,0,0,-6,0,0,0,0,-2,0,2,-4,0,0,0,0,-8,0,-3,-5,-12,0,-12,-6,-0.495187436676798,-0.119121447028424,-0.34132892409444,-0.143222506393862,-0.0602094240837696,0.642105263157895,-0.995881383855025,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","150/150","H",3.24545333052325,2.7826871320661e-09,0.546011377839736,5.94392985612077,9.76352440503871,88.06998811648,1.40948247478545,4.51976315688199e-13,12.3448843223466,8.64707452935555,102.96388402837,6.29217184975434e-18,"lineage4","dr_mutations_pyrazinamide","TYR",0,"ERR2516017","ERR2516017","lineage4.1.2.1","za","South Africa","pnca_p.his71tyr","A","-","HIS","HA71","pnca_complex.pdb"
|
|
"H71Y","L4","PZA","H","H71",71,"Y",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","basic","neutral","pos","polar",4.184,-1.955,-0.461,-1.77532,-0.84,-0.23,61,80,-1.209,9,9,5,0.0223214285714285,"loop",-0.766666666666667,6.25,0.0017967514733362,25.6733460559796,25.6733459339263,25.6638623299459,74.4270249019608,-26,-6,0,0,-6,0,0,0,0,-2,0,2,-4,0,0,0,0,-8,0,-3,-5,-12,0,-12,-6,-0.495187436676798,-0.119121447028424,-0.34132892409444,-0.143222506393862,-0.0602094240837696,0.642105263157895,-0.995881383855025,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","150/150","H",3.24545333052325,2.7826871320661e-09,0.546011377839736,5.94392985612077,9.76352440503871,88.06998811648,1.40948247478545,4.51976315688199e-13,12.3448843223466,8.64707452935555,102.96388402837,6.29217184975434e-18,"lineage4","dr_mutations_pyrazinamide","TYR",0,"ERR2515135","ERR2515135","lineage4.1.2.1","za","South Africa","pnca_p.his71tyr","A","-","HIS","HA71","pnca_complex.pdb"
|
|
"H71Y","L4","PZA","H","H71",71,"Y",NA,"MDR","DM","hydrophobic","hydrophobic","basic","neutral","pos","polar",4.184,-1.955,-0.461,-1.77532,-0.84,-0.23,61,80,-1.209,9,9,5,0.0223214285714285,"loop",-0.766666666666667,6.25,0.0017967514733362,25.6733460559796,25.6733459339263,25.6638623299459,74.4270249019608,-26,-6,0,0,-6,0,0,0,0,-2,0,2,-4,0,0,0,0,-8,0,-3,-5,-12,0,-12,-6,-0.495187436676798,-0.119121447028424,-0.34132892409444,-0.143222506393862,-0.0602094240837696,0.642105263157895,-0.995881383855025,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","150/150","H",3.24545333052325,2.7826871320661e-09,0.546011377839736,5.94392985612077,9.76352440503871,88.06998811648,1.40948247478545,4.51976315688199e-13,12.3448843223466,8.64707452935555,102.96388402837,6.29217184975434e-18,"lineage4","dr_mutations_pyrazinamide","TYR",0,"SRR4034390","SRR4034390","lineage4.1.2.1","za","South Africa: Kwazulu-Natal","pnca_p.his71tyr","A","-","HIS","HA71","pnca_complex.pdb"
|
|
"H71Y","L4","PZA","H","H71",71,"Y",1,"MDR","DM","hydrophobic","hydrophobic","basic","neutral","pos","polar",4.184,-1.955,-0.461,-1.77532,-0.84,-0.23,61,80,-1.209,9,9,5,0.0223214285714285,"loop",-0.766666666666667,6.25,0.0017967514733362,25.6733460559796,25.6733459339263,25.6638623299459,74.4270249019608,-26,-6,0,0,-6,0,0,0,0,-2,0,2,-4,0,0,0,0,-8,0,-3,-5,-12,0,-12,-6,-0.495187436676798,-0.119121447028424,-0.34132892409444,-0.143222506393862,-0.0602094240837696,0.642105263157895,-0.995881383855025,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","150/150","H",3.24545333052325,2.7826871320661e-09,0.546011377839736,5.94392985612077,9.76352440503871,88.06998811648,1.40948247478545,4.51976315688199e-13,12.3448843223466,8.64707452935555,102.96388402837,6.29217184975434e-18,"lineage4","dr_mutations_pyrazinamide","TYR",0,"SAMN02053753","SRR833032_SRR833131","lineage4.1.2.1","za","South Africa","pnca_p.his71tyr","A","-","HIS","HA71","pnca_complex.pdb"
|
|
"H71Y","L4","PZA","H","H71",71,"Y",NA,"MDR","DM","hydrophobic","hydrophobic","basic","neutral","pos","polar",4.184,-1.955,-0.461,-1.77532,-0.84,-0.23,61,80,-1.209,9,9,5,0.0223214285714285,"loop",-0.766666666666667,6.25,0.0017967514733362,25.6733460559796,25.6733459339263,25.6638623299459,74.4270249019608,-26,-6,0,0,-6,0,0,0,0,-2,0,2,-4,0,0,0,0,-8,0,-3,-5,-12,0,-12,-6,-0.495187436676798,-0.119121447028424,-0.34132892409444,-0.143222506393862,-0.0602094240837696,0.642105263157895,-0.995881383855025,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","150/150","H",3.24545333052325,2.7826871320661e-09,0.546011377839736,5.94392985612077,9.76352440503871,88.06998811648,1.40948247478545,4.51976315688199e-13,12.3448843223466,8.64707452935555,102.96388402837,6.29217184975434e-18,"lineage4","dr_mutations_pyrazinamide","TYR",0,"SRR4034386","SRR4034386","lineage4.1.2.1","za","South Africa: Kwazulu-Natal","pnca_p.his71tyr","A","-","HIS","HA71","pnca_complex.pdb"
|
|
"H71Y","L2","PZA","H","H71",71,"Y",1,"MDR","DM","hydrophobic","hydrophobic","basic","neutral","pos","polar",4.184,-1.955,-0.461,-1.77532,-0.84,-0.23,61,80,-1.209,9,9,5,0.0223214285714285,"loop",-0.766666666666667,6.25,0.0017967514733362,25.6733460559796,25.6733459339263,25.6638623299459,74.4270249019608,-26,-6,0,0,-6,0,0,0,0,-2,0,2,-4,0,0,0,0,-8,0,-3,-5,-12,0,-12,-6,-0.495187436676798,-0.119121447028424,-0.34132892409444,-0.143222506393862,-0.0602094240837696,0.642105263157895,-0.995881383855025,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","150/150","H",3.24545333052325,2.7826871320661e-09,0.546011377839736,5.94392985612077,9.76352440503871,88.06998811648,1.40948247478545,4.51976315688199e-13,12.3448843223466,8.64707452935555,102.96388402837,6.29217184975434e-18,"lineage2","dr_mutations_pyrazinamide","TYR",0,"ERR2516973","ERR2516973","lineage2.2.1","gb","UK","pnca_p.his71tyr","A","-","HIS","HA71","pnca_complex.pdb"
|
|
"H71Y","L4","PZA","H","H71",71,"Y",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","basic","neutral","pos","polar",4.184,-1.955,-0.461,-1.77532,-0.84,-0.23,61,80,-1.209,9,9,5,0.0223214285714285,"loop",-0.766666666666667,6.25,0.0017967514733362,25.6733460559796,25.6733459339263,25.6638623299459,74.4270249019608,-26,-6,0,0,-6,0,0,0,0,-2,0,2,-4,0,0,0,0,-8,0,-3,-5,-12,0,-12,-6,-0.495187436676798,-0.119121447028424,-0.34132892409444,-0.143222506393862,-0.0602094240837696,0.642105263157895,-0.995881383855025,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","150/150","H",3.24545333052325,2.7826871320661e-09,0.546011377839736,5.94392985612077,9.76352440503871,88.06998811648,1.40948247478545,4.51976315688199e-13,12.3448843223466,8.64707452935555,102.96388402837,6.29217184975434e-18,"lineage4","dr_mutations_pyrazinamide","TYR",0,"SAMN02585961","SRR1181171_SRR1180181_SRR1183124_SRR1181284","lineage4.1.2.1","za","South Africa","pnca_p.his71tyr","A","-","HIS","HA71","pnca_complex.pdb"
|
|
"H71Y","L2","PZA","H","H71",71,"Y",1,"MDR","DM","hydrophobic","hydrophobic","basic","neutral","pos","polar",4.184,-1.955,-0.461,-1.77532,-0.84,-0.23,61,80,-1.209,9,9,5,0.0223214285714285,"loop",-0.766666666666667,6.25,0.0017967514733362,25.6733460559796,25.6733459339263,25.6638623299459,74.4270249019608,-26,-6,0,0,-6,0,0,0,0,-2,0,2,-4,0,0,0,0,-8,0,-3,-5,-12,0,-12,-6,-0.495187436676798,-0.119121447028424,-0.34132892409444,-0.143222506393862,-0.0602094240837696,0.642105263157895,-0.995881383855025,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","150/150","H",3.24545333052325,2.7826871320661e-09,0.546011377839736,5.94392985612077,9.76352440503871,88.06998811648,1.40948247478545,4.51976315688199e-13,12.3448843223466,8.64707452935555,102.96388402837,6.29217184975434e-18,"lineage2","dr_mutations_pyrazinamide","TYR",0,"ERR2516759","ERR2516759","lineage2.2.1","gb","UK","pnca_p.his71tyr","A","-","HIS","HA71","pnca_complex.pdb"
|
|
"H71Y","L4","PZA","H","H71",71,"Y",0,"MDR","DM","hydrophobic","hydrophobic","basic","neutral","pos","polar",4.184,-1.955,-0.461,-1.77532,-0.84,-0.23,61,80,-1.209,9,9,5,0.0223214285714285,"loop",-0.766666666666667,6.25,0.0017967514733362,25.6733460559796,25.6733459339263,25.6638623299459,74.4270249019608,-26,-6,0,0,-6,0,0,0,0,-2,0,2,-4,0,0,0,0,-8,0,-3,-5,-12,0,-12,-6,-0.495187436676798,-0.119121447028424,-0.34132892409444,-0.143222506393862,-0.0602094240837696,0.642105263157895,-0.995881383855025,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","150/150","H",3.24545333052325,2.7826871320661e-09,0.546011377839736,5.94392985612077,9.76352440503871,88.06998811648,1.40948247478545,4.51976315688199e-13,12.3448843223466,8.64707452935555,102.96388402837,6.29217184975434e-18,"lineage4","dr_mutations_pyrazinamide","TYR",0,"SRR2101360,SAMN03648607","SRR2101360","lineage4.1.2.1","","","pnca_p.his71tyr","A","-","HIS","HA71","pnca_complex.pdb"
|
|
"H71Y","L4","PZA","H","H71",71,"Y",1,"MDR","DM","hydrophobic","hydrophobic","basic","neutral","pos","polar",4.184,-1.955,-0.461,-1.77532,-0.84,-0.23,61,80,-1.209,9,9,5,0.0223214285714285,"loop",-0.766666666666667,6.25,0.0017967514733362,25.6733460559796,25.6733459339263,25.6638623299459,74.4270249019608,-26,-6,0,0,-6,0,0,0,0,-2,0,2,-4,0,0,0,0,-8,0,-3,-5,-12,0,-12,-6,-0.495187436676798,-0.119121447028424,-0.34132892409444,-0.143222506393862,-0.0602094240837696,0.642105263157895,-0.995881383855025,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","150/150","H",3.24545333052325,2.7826871320661e-09,0.546011377839736,5.94392985612077,9.76352440503871,88.06998811648,1.40948247478545,4.51976315688199e-13,12.3448843223466,8.64707452935555,102.96388402837,6.29217184975434e-18,"lineage4","dr_mutations_pyrazinamide","TYR",0,"ERR2510492","ERR2510492","lineage4.5","pk","Pakistan","pnca_p.his71tyr","A","-","HIS","HA71","pnca_complex.pdb"
|
|
"H71Y","L2","PZA","H","H71",71,"Y",1,"Pre-XDR","DM","hydrophobic","hydrophobic","basic","neutral","pos","polar",4.184,-1.955,-0.461,-1.77532,-0.84,-0.23,61,80,-1.209,9,9,5,0.0223214285714285,"loop",-0.766666666666667,6.25,0.0017967514733362,25.6733460559796,25.6733459339263,25.6638623299459,74.4270249019608,-26,-6,0,0,-6,0,0,0,0,-2,0,2,-4,0,0,0,0,-8,0,-3,-5,-12,0,-12,-6,-0.495187436676798,-0.119121447028424,-0.34132892409444,-0.143222506393862,-0.0602094240837696,0.642105263157895,-0.995881383855025,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","150/150","H",3.24545333052325,2.7826871320661e-09,0.546011377839736,5.94392985612077,9.76352440503871,88.06998811648,1.40948247478545,4.51976315688199e-13,12.3448843223466,8.64707452935555,102.96388402837,6.29217184975434e-18,"lineage2","dr_mutations_pyrazinamide","TYR",0,"ERR3335785","ERR3335785","lineage2.2.1","pk","Pakistan","pnca_p.his71tyr","A","-","HIS","HA71","pnca_complex.pdb"
|
|
"H71Y","L4","PZA","H","H71",71,"Y",1,"Pre-XDR","DM","hydrophobic","hydrophobic","basic","neutral","pos","polar",4.184,-1.955,-0.461,-1.77532,-0.84,-0.23,61,80,-1.209,9,9,5,0.0223214285714285,"loop",-0.766666666666667,6.25,0.0017967514733362,25.6733460559796,25.6733459339263,25.6638623299459,74.4270249019608,-26,-6,0,0,-6,0,0,0,0,-2,0,2,-4,0,0,0,0,-8,0,-3,-5,-12,0,-12,-6,-0.495187436676798,-0.119121447028424,-0.34132892409444,-0.143222506393862,-0.0602094240837696,0.642105263157895,-0.995881383855025,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","150/150","H",3.24545333052325,2.7826871320661e-09,0.546011377839736,5.94392985612077,9.76352440503871,88.06998811648,1.40948247478545,4.51976315688199e-13,12.3448843223466,8.64707452935555,102.96388402837,6.29217184975434e-18,"lineage4","dr_mutations_pyrazinamide","TYR",0,"ERR2516091","ERR2516091","lineage4.1.2.1","za","South Africa","pnca_p.his71tyr","A","-","HIS","HA71","pnca_complex.pdb"
|
|
"H71Y","L4","PZA","H","H71",71,"Y",1,"MDR","DM","hydrophobic","hydrophobic","basic","neutral","pos","polar",4.184,-1.955,-0.461,-1.77532,-0.84,-0.23,61,80,-1.209,9,9,5,0.0223214285714285,"loop",-0.766666666666667,6.25,0.0017967514733362,25.6733460559796,25.6733459339263,25.6638623299459,74.4270249019608,-26,-6,0,0,-6,0,0,0,0,-2,0,2,-4,0,0,0,0,-8,0,-3,-5,-12,0,-12,-6,-0.495187436676798,-0.119121447028424,-0.34132892409444,-0.143222506393862,-0.0602094240837696,0.642105263157895,-0.995881383855025,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","150/150","H",3.24545333052325,2.7826871320661e-09,0.546011377839736,5.94392985612077,9.76352440503871,88.06998811648,1.40948247478545,4.51976315688199e-13,12.3448843223466,8.64707452935555,102.96388402837,6.29217184975434e-18,"lineage4","dr_mutations_pyrazinamide","TYR",0,"ERR2515982","ERR2515982","lineage4.1.2.1","za","South Africa","pnca_p.his71tyr","A","-","HIS","HA71","pnca_complex.pdb"
|
|
"H71Y","L4","PZA","H","H71",71,"Y",NA,"MDR","DM","hydrophobic","hydrophobic","basic","neutral","pos","polar",4.184,-1.955,-0.461,-1.77532,-0.84,-0.23,61,80,-1.209,9,9,5,0.0223214285714285,"loop",-0.766666666666667,6.25,0.0017967514733362,25.6733460559796,25.6733459339263,25.6638623299459,74.4270249019608,-26,-6,0,0,-6,0,0,0,0,-2,0,2,-4,0,0,0,0,-8,0,-3,-5,-12,0,-12,-6,-0.495187436676798,-0.119121447028424,-0.34132892409444,-0.143222506393862,-0.0602094240837696,0.642105263157895,-0.995881383855025,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","150/150","H",3.24545333052325,2.7826871320661e-09,0.546011377839736,5.94392985612077,9.76352440503871,88.06998811648,1.40948247478545,4.51976315688199e-13,12.3448843223466,8.64707452935555,102.96388402837,6.29217184975434e-18,"lineage4","dr_mutations_pyrazinamide","TYR",0,"SRR4034393","SRR4034393","lineage4.1.2.1","za","South Africa: Kwazulu-Natal","pnca_p.his71tyr","A","-","HIS","HA71","pnca_complex.pdb"
|
|
"H71Y","L2","PZA","H","H71",71,"Y",0,"MDR","DM","hydrophobic","hydrophobic","basic","neutral","pos","polar",4.184,-1.955,-0.461,-1.77532,-0.84,-0.23,61,80,-1.209,9,9,5,0.0223214285714285,"loop",-0.766666666666667,6.25,0.0017967514733362,25.6733460559796,25.6733459339263,25.6638623299459,74.4270249019608,-26,-6,0,0,-6,0,0,0,0,-2,0,2,-4,0,0,0,0,-8,0,-3,-5,-12,0,-12,-6,-0.495187436676798,-0.119121447028424,-0.34132892409444,-0.143222506393862,-0.0602094240837696,0.642105263157895,-0.995881383855025,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","150/150","H",3.24545333052325,2.7826871320661e-09,0.546011377839736,5.94392985612077,9.76352440503871,88.06998811648,1.40948247478545,4.51976315688199e-13,12.3448843223466,8.64707452935555,102.96388402837,6.29217184975434e-18,"lineage2","dr_mutations_pyrazinamide","TYR",0,"ERR2516866","ERR2516866","lineage2.2.1","gb","UK","pnca_p.his71tyr","A","-","HIS","HA71","pnca_complex.pdb"
|
|
"H71Y","L4","PZA","H","H71",71,"Y",NA,"MDR","DM","hydrophobic","hydrophobic","basic","neutral","pos","polar",4.184,-1.955,-0.461,-1.77532,-0.84,-0.23,61,80,-1.209,9,9,5,0.0223214285714285,"loop",-0.766666666666667,6.25,0.0017967514733362,25.6733460559796,25.6733459339263,25.6638623299459,74.4270249019608,-26,-6,0,0,-6,0,0,0,0,-2,0,2,-4,0,0,0,0,-8,0,-3,-5,-12,0,-12,-6,-0.495187436676798,-0.119121447028424,-0.34132892409444,-0.143222506393862,-0.0602094240837696,0.642105263157895,-0.995881383855025,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","150/150","H",3.24545333052325,2.7826871320661e-09,0.546011377839736,5.94392985612077,9.76352440503871,88.06998811648,1.40948247478545,4.51976315688199e-13,12.3448843223466,8.64707452935555,102.96388402837,6.29217184975434e-18,"lineage4","dr_mutations_pyrazinamide","TYR",0,"SRR4034391","SRR4034391","lineage4.1.2.1","za","South Africa: Kwazulu-Natal","pnca_p.his71tyr","A","-","HIS","HA71","pnca_complex.pdb"
|
|
"H71Y","L4","PZA","H","H71",71,"Y",1,"Pre-XDR","DM","hydrophobic","hydrophobic","basic","neutral","pos","polar",4.184,-1.955,-0.461,-1.77532,-0.84,-0.23,61,80,-1.209,9,9,5,0.0223214285714285,"loop",-0.766666666666667,6.25,0.0017967514733362,25.6733460559796,25.6733459339263,25.6638623299459,74.4270249019608,-26,-6,0,0,-6,0,0,0,0,-2,0,2,-4,0,0,0,0,-8,0,-3,-5,-12,0,-12,-6,-0.495187436676798,-0.119121447028424,-0.34132892409444,-0.143222506393862,-0.0602094240837696,0.642105263157895,-0.995881383855025,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","150/150","H",3.24545333052325,2.7826871320661e-09,0.546011377839736,5.94392985612077,9.76352440503871,88.06998811648,1.40948247478545,4.51976315688199e-13,12.3448843223466,8.64707452935555,102.96388402837,6.29217184975434e-18,"lineage4","dr_mutations_pyrazinamide","TYR",0,"ERR2510413","ERR2510413","lineage4.5","pk","Pakistan","pnca_p.his71tyr","A","-","HIS","HA71","pnca_complex.pdb"
|
|
"H71Y","L4","PZA","H","H71",71,"Y",NA,"XDR","DM","hydrophobic","hydrophobic","basic","neutral","pos","polar",4.184,-1.955,-0.461,-1.77532,-0.84,-0.23,61,80,-1.209,9,9,5,0.0223214285714285,"loop",-0.766666666666667,6.25,0.0017967514733362,25.6733460559796,25.6733459339263,25.6638623299459,74.4270249019608,-26,-6,0,0,-6,0,0,0,0,-2,0,2,-4,0,0,0,0,-8,0,-3,-5,-12,0,-12,-6,-0.495187436676798,-0.119121447028424,-0.34132892409444,-0.143222506393862,-0.0602094240837696,0.642105263157895,-0.995881383855025,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","150/150","H",3.24545333052325,2.7826871320661e-09,0.546011377839736,5.94392985612077,9.76352440503871,88.06998811648,1.40948247478545,4.51976315688199e-13,12.3448843223466,8.64707452935555,102.96388402837,6.29217184975434e-18,"lineage4","dr_mutations_pyrazinamide","TYR",0,"ERR2515361","ERR2515361","lineage4.1.2.1","za","South Africa","pnca_p.his71tyr","A","-","HIS","HA71","pnca_complex.pdb"
|
|
"H71Y","L2","PZA","H","H71",71,"Y",NA,"MDR","DM","hydrophobic","hydrophobic","basic","neutral","pos","polar",4.184,-1.955,-0.461,-1.77532,-0.84,-0.23,61,80,-1.209,9,9,5,0.0223214285714285,"loop",-0.766666666666667,6.25,0.0017967514733362,25.6733460559796,25.6733459339263,25.6638623299459,74.4270249019608,-26,-6,0,0,-6,0,0,0,0,-2,0,2,-4,0,0,0,0,-8,0,-3,-5,-12,0,-12,-6,-0.495187436676798,-0.119121447028424,-0.34132892409444,-0.143222506393862,-0.0602094240837696,0.642105263157895,-0.995881383855025,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","150/150","H",3.24545333052325,2.7826871320661e-09,0.546011377839736,5.94392985612077,9.76352440503871,88.06998811648,1.40948247478545,4.51976315688199e-13,12.3448843223466,8.64707452935555,102.96388402837,6.29217184975434e-18,"lineage2","dr_mutations_pyrazinamide","TYR",0,"hlj100176","SRR960978","lineage2.2.1","cn","China","pnca_p.his71tyr","A","-","HIS","HA71","pnca_complex.pdb"
|
|
"H71Y","L4","PZA","H","H71",71,"Y",1,"Pre-XDR","DM","hydrophobic","hydrophobic","basic","neutral","pos","polar",4.184,-1.955,-0.461,-1.77532,-0.84,-0.23,61,80,-1.209,9,9,5,0.0223214285714285,"loop",-0.766666666666667,6.25,0.0017967514733362,25.6733460559796,25.6733459339263,25.6638623299459,74.4270249019608,-26,-6,0,0,-6,0,0,0,0,-2,0,2,-4,0,0,0,0,-8,0,-3,-5,-12,0,-12,-6,-0.495187436676798,-0.119121447028424,-0.34132892409444,-0.143222506393862,-0.0602094240837696,0.642105263157895,-0.995881383855025,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","150/150","H",3.24545333052325,2.7826871320661e-09,0.546011377839736,5.94392985612077,9.76352440503871,88.06998811648,1.40948247478545,4.51976315688199e-13,12.3448843223466,8.64707452935555,102.96388402837,6.29217184975434e-18,"lineage4","dr_mutations_pyrazinamide","TYR",0,"ERR2515264","ERR2515264","lineage4.1.2.1","za","South Africa","pnca_p.his71tyr","A","-","HIS","HA71","pnca_complex.pdb"
|
|
"H71Y","L4","PZA","H","H71",71,"Y",1,"MDR","DM","hydrophobic","hydrophobic","basic","neutral","pos","polar",4.184,-1.955,-0.461,-1.77532,-0.84,-0.23,61,80,-1.209,9,9,5,0.0223214285714285,"loop",-0.766666666666667,6.25,0.0017967514733362,25.6733460559796,25.6733459339263,25.6638623299459,74.4270249019608,-26,-6,0,0,-6,0,0,0,0,-2,0,2,-4,0,0,0,0,-8,0,-3,-5,-12,0,-12,-6,-0.495187436676798,-0.119121447028424,-0.34132892409444,-0.143222506393862,-0.0602094240837696,0.642105263157895,-0.995881383855025,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","150/150","H",3.24545333052325,2.7826871320661e-09,0.546011377839736,5.94392985612077,9.76352440503871,88.06998811648,1.40948247478545,4.51976315688199e-13,12.3448843223466,8.64707452935555,102.96388402837,6.29217184975434e-18,"lineage4","dr_mutations_pyrazinamide","TYR",0,"ERR2515583","ERR2515583","lineage4.1.2.1","za","South Africa","pnca_p.his71tyr","A","-","HIS","HA71","pnca_complex.pdb"
|
|
"H71Y","L4","PZA","H","H71",71,"Y",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","basic","neutral","pos","polar",4.184,-1.955,-0.461,-1.77532,-0.84,-0.23,61,80,-1.209,9,9,5,0.0223214285714285,"loop",-0.766666666666667,6.25,0.0017967514733362,25.6733460559796,25.6733459339263,25.6638623299459,74.4270249019608,-26,-6,0,0,-6,0,0,0,0,-2,0,2,-4,0,0,0,0,-8,0,-3,-5,-12,0,-12,-6,-0.495187436676798,-0.119121447028424,-0.34132892409444,-0.143222506393862,-0.0602094240837696,0.642105263157895,-0.995881383855025,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","150/150","H",3.24545333052325,2.7826871320661e-09,0.546011377839736,5.94392985612077,9.76352440503871,88.06998811648,1.40948247478545,4.51976315688199e-13,12.3448843223466,8.64707452935555,102.96388402837,6.29217184975434e-18,"lineage4","dr_mutations_pyrazinamide","TYR",0,"SAMN02585972","SRR1180419_SRR1180276_SRR1181279_SRR1181092","lineage4.1.2.1","za","South Africa","pnca_p.his71tyr","A","-","HIS","HA71","pnca_complex.pdb"
|
|
"H71Y","L2","PZA","H","H71",71,"Y",NA,"MDR","DM","hydrophobic","hydrophobic","basic","neutral","pos","polar",4.184,-1.955,-0.461,-1.77532,-0.84,-0.23,61,80,-1.209,9,9,5,0.0223214285714285,"loop",-0.766666666666667,6.25,0.0017967514733362,25.6733460559796,25.6733459339263,25.6638623299459,74.4270249019608,-26,-6,0,0,-6,0,0,0,0,-2,0,2,-4,0,0,0,0,-8,0,-3,-5,-12,0,-12,-6,-0.495187436676798,-0.119121447028424,-0.34132892409444,-0.143222506393862,-0.0602094240837696,0.642105263157895,-0.995881383855025,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","150/150","H",3.24545333052325,2.7826871320661e-09,0.546011377839736,5.94392985612077,9.76352440503871,88.06998811648,1.40948247478545,4.51976315688199e-13,12.3448843223466,8.64707452935555,102.96388402837,6.29217184975434e-18,"lineage2","dr_mutations_pyrazinamide","TYR",0,"SAMN02584608","SRR1169036_SRR1166187","lineage2.2.1","md","Moldova","pnca_p.his71tyr","A","-","HIS","HA71","pnca_complex.pdb"
|
|
"H71Y","L2","PZA","H","H71",71,"Y",1,"MDR","DM","hydrophobic","hydrophobic","basic","neutral","pos","polar",4.184,-1.955,-0.461,-1.77532,-0.84,-0.23,61,80,-1.209,9,9,5,0.0223214285714285,"loop",-0.766666666666667,6.25,0.0017967514733362,25.6733460559796,25.6733459339263,25.6638623299459,74.4270249019608,-26,-6,0,0,-6,0,0,0,0,-2,0,2,-4,0,0,0,0,-8,0,-3,-5,-12,0,-12,-6,-0.495187436676798,-0.119121447028424,-0.34132892409444,-0.143222506393862,-0.0602094240837696,0.642105263157895,-0.995881383855025,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","150/150","H",3.24545333052325,2.7826871320661e-09,0.546011377839736,5.94392985612077,9.76352440503871,88.06998811648,1.40948247478545,4.51976315688199e-13,12.3448843223466,8.64707452935555,102.96388402837,6.29217184975434e-18,"lineage2","dr_mutations_pyrazinamide","TYR",0,"ERR2517083","ERR2517083","lineage2.2.1","gb","UK","pnca_p.his71tyr","A","-","HIS","HA71","pnca_complex.pdb"
|
|
"H71Y","L2","PZA","H","H71",71,"Y",0,"MDR","DM","hydrophobic","hydrophobic","basic","neutral","pos","polar",4.184,-1.955,-0.461,-1.77532,-0.84,-0.23,61,80,-1.209,9,9,5,0.0223214285714285,"loop",-0.766666666666667,6.25,0.0017967514733362,25.6733460559796,25.6733459339263,25.6638623299459,74.4270249019608,-26,-6,0,0,-6,0,0,0,0,-2,0,2,-4,0,0,0,0,-8,0,-3,-5,-12,0,-12,-6,-0.495187436676798,-0.119121447028424,-0.34132892409444,-0.143222506393862,-0.0602094240837696,0.642105263157895,-0.995881383855025,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","150/150","H",3.24545333052325,2.7826871320661e-09,0.546011377839736,5.94392985612077,9.76352440503871,88.06998811648,1.40948247478545,4.51976315688199e-13,12.3448843223466,8.64707452935555,102.96388402837,6.29217184975434e-18,"lineage2","dr_mutations_pyrazinamide","TYR",0,"ERR2516826","ERR2516826","lineage2.2.1","gb","UK","pnca_p.his71tyr","A","-","HIS","HA71","pnca_complex.pdb"
|
|
"H71Y","L4","PZA","H","H71",71,"Y",NA,"XDR","DM","hydrophobic","hydrophobic","basic","neutral","pos","polar",4.184,-1.955,-0.461,-1.77532,-0.84,-0.23,61,80,-1.209,9,9,5,0.0223214285714285,"loop",-0.766666666666667,6.25,0.0017967514733362,25.6733460559796,25.6733459339263,25.6638623299459,74.4270249019608,-26,-6,0,0,-6,0,0,0,0,-2,0,2,-4,0,0,0,0,-8,0,-3,-5,-12,0,-12,-6,-0.495187436676798,-0.119121447028424,-0.34132892409444,-0.143222506393862,-0.0602094240837696,0.642105263157895,-0.995881383855025,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","150/150","H",3.24545333052325,2.7826871320661e-09,0.546011377839736,5.94392985612077,9.76352440503871,88.06998811648,1.40948247478545,4.51976315688199e-13,12.3448843223466,8.64707452935555,102.96388402837,6.29217184975434e-18,"lineage4","dr_mutations_pyrazinamide","TYR",0,"ERR2515199","ERR2515199","lineage4.1.2.1","za","South Africa","pnca_p.his71tyr","A","-","HIS","HA71","pnca_complex.pdb"
|
|
"H71Y","L4","PZA","H","H71",71,"Y",NA,"MDR","DM","hydrophobic","hydrophobic","basic","neutral","pos","polar",4.184,-1.955,-0.461,-1.77532,-0.84,-0.23,61,80,-1.209,9,9,5,0.0223214285714285,"loop",-0.766666666666667,6.25,0.0017967514733362,25.6733460559796,25.6733459339263,25.6638623299459,74.4270249019608,-26,-6,0,0,-6,0,0,0,0,-2,0,2,-4,0,0,0,0,-8,0,-3,-5,-12,0,-12,-6,-0.495187436676798,-0.119121447028424,-0.34132892409444,-0.143222506393862,-0.0602094240837696,0.642105263157895,-0.995881383855025,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","150/150","H",3.24545333052325,2.7826871320661e-09,0.546011377839736,5.94392985612077,9.76352440503871,88.06998811648,1.40948247478545,4.51976315688199e-13,12.3448843223466,8.64707452935555,102.96388402837,6.29217184975434e-18,"lineage4","dr_mutations_pyrazinamide","TYR",0,"SRR4034389","SRR4034389","lineage4.1.2.1","za","South Africa: Kwazulu-Natal","pnca_p.his71tyr","A","-","HIS","HA71","pnca_complex.pdb"
|
|
"H71Y","L4","PZA","H","H71",71,"Y",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","basic","neutral","pos","polar",4.184,-1.955,-0.461,-1.77532,-0.84,-0.23,61,80,-1.209,9,9,5,0.0223214285714285,"loop",-0.766666666666667,6.25,0.0017967514733362,25.6733460559796,25.6733459339263,25.6638623299459,74.4270249019608,-26,-6,0,0,-6,0,0,0,0,-2,0,2,-4,0,0,0,0,-8,0,-3,-5,-12,0,-12,-6,-0.495187436676798,-0.119121447028424,-0.34132892409444,-0.143222506393862,-0.0602094240837696,0.642105263157895,-0.995881383855025,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","150/150","H",3.24545333052325,2.7826871320661e-09,0.546011377839736,5.94392985612077,9.76352440503871,88.06998811648,1.40948247478545,4.51976315688199e-13,12.3448843223466,8.64707452935555,102.96388402837,6.29217184975434e-18,"lineage4","dr_mutations_pyrazinamide","TYR",0,"ERR2516023","ERR2516023","lineage4.1.2.1","za","South Africa","pnca_p.his71tyr","A","-","HIS","HA71","pnca_complex.pdb"
|
|
"H71Y","L4","PZA","H","H71",71,"Y",1,"Pre-MDR","DM","hydrophobic","hydrophobic","basic","neutral","pos","polar",4.184,-1.955,-0.461,-1.77532,-0.84,-0.23,61,80,-1.209,9,9,5,0.0223214285714285,"loop",-0.766666666666667,6.25,0.0017967514733362,25.6733460559796,25.6733459339263,25.6638623299459,74.4270249019608,-26,-6,0,0,-6,0,0,0,0,-2,0,2,-4,0,0,0,0,-8,0,-3,-5,-12,0,-12,-6,-0.495187436676798,-0.119121447028424,-0.34132892409444,-0.143222506393862,-0.0602094240837696,0.642105263157895,-0.995881383855025,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","150/150","H",3.24545333052325,2.7826871320661e-09,0.546011377839736,5.94392985612077,9.76352440503871,88.06998811648,1.40948247478545,4.51976315688199e-13,12.3448843223466,8.64707452935555,102.96388402837,6.29217184975434e-18,"lineage4","dr_mutations_pyrazinamide","TYR",0,"ERR2516027","ERR2516027","lineage4.4.1.1","za","South Africa","pnca_p.his71tyr","A","-","HIS","HA71","pnca_complex.pdb"
|
|
"H71Y","L4","PZA","H","H71",71,"Y",NA,"MDR","DM","hydrophobic","hydrophobic","basic","neutral","pos","polar",4.184,-1.955,-0.461,-1.77532,-0.84,-0.23,61,80,-1.209,9,9,5,0.0223214285714285,"loop",-0.766666666666667,6.25,0.0017967514733362,25.6733460559796,25.6733459339263,25.6638623299459,74.4270249019608,-26,-6,0,0,-6,0,0,0,0,-2,0,2,-4,0,0,0,0,-8,0,-3,-5,-12,0,-12,-6,-0.495187436676798,-0.119121447028424,-0.34132892409444,-0.143222506393862,-0.0602094240837696,0.642105263157895,-0.995881383855025,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","150/150","H",3.24545333052325,2.7826871320661e-09,0.546011377839736,5.94392985612077,9.76352440503871,88.06998811648,1.40948247478545,4.51976315688199e-13,12.3448843223466,8.64707452935555,102.96388402837,6.29217184975434e-18,"lineage4","dr_mutations_pyrazinamide","TYR",0,"SRR4034387","SRR4034387","lineage4.1.2.1","za","South Africa: Kwazulu-Natal","pnca_p.his71tyr","A","-","HIS","HA71","pnca_complex.pdb"
|
|
"H71Y","L4","PZA","H","H71",71,"Y",1,"MDR","DM","hydrophobic","hydrophobic","basic","neutral","pos","polar",4.184,-1.955,-0.461,-1.77532,-0.84,-0.23,61,80,-1.209,9,9,5,0.0223214285714285,"loop",-0.766666666666667,6.25,0.0017967514733362,25.6733460559796,25.6733459339263,25.6638623299459,74.4270249019608,-26,-6,0,0,-6,0,0,0,0,-2,0,2,-4,0,0,0,0,-8,0,-3,-5,-12,0,-12,-6,-0.495187436676798,-0.119121447028424,-0.34132892409444,-0.143222506393862,-0.0602094240837696,0.642105263157895,-0.995881383855025,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","150/150","H",3.24545333052325,2.7826871320661e-09,0.546011377839736,5.94392985612077,9.76352440503871,88.06998811648,1.40948247478545,4.51976315688199e-13,12.3448843223466,8.64707452935555,102.96388402837,6.29217184975434e-18,"lineage4","dr_mutations_pyrazinamide","TYR",0,"ERR553053","ERR553053","lineage4.1.2.1","sz","Swaziland","pnca_p.his71tyr","A","-","HIS","HA71","pnca_complex.pdb"
|
|
"H71Y","L4","PZA","H","H71",71,"Y",1,"MDR","DM","hydrophobic","hydrophobic","basic","neutral","pos","polar",4.184,-1.955,-0.461,-1.77532,-0.84,-0.23,61,80,-1.209,9,9,5,0.0223214285714285,"loop",-0.766666666666667,6.25,0.0017967514733362,25.6733460559796,25.6733459339263,25.6638623299459,74.4270249019608,-26,-6,0,0,-6,0,0,0,0,-2,0,2,-4,0,0,0,0,-8,0,-3,-5,-12,0,-12,-6,-0.495187436676798,-0.119121447028424,-0.34132892409444,-0.143222506393862,-0.0602094240837696,0.642105263157895,-0.995881383855025,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","150/150","H",3.24545333052325,2.7826871320661e-09,0.546011377839736,5.94392985612077,9.76352440503871,88.06998811648,1.40948247478545,4.51976315688199e-13,12.3448843223466,8.64707452935555,102.96388402837,6.29217184975434e-18,"lineage4","dr_mutations_pyrazinamide","TYR",0,"ERR2515542","ERR2515542","lineage4.1.2.1","za","South Africa","pnca_p.his71tyr","A","-","HIS","HA71","pnca_complex.pdb"
|
|
"H71Y","L4","PZA","H","H71",71,"Y",NA,"MDR","DM","hydrophobic","hydrophobic","basic","neutral","pos","polar",4.184,-1.955,-0.461,-1.77532,-0.84,-0.23,61,80,-1.209,9,9,5,0.0223214285714285,"loop",-0.766666666666667,6.25,0.0017967514733362,25.6733460559796,25.6733459339263,25.6638623299459,74.4270249019608,-26,-6,0,0,-6,0,0,0,0,-2,0,2,-4,0,0,0,0,-8,0,-3,-5,-12,0,-12,-6,-0.495187436676798,-0.119121447028424,-0.34132892409444,-0.143222506393862,-0.0602094240837696,0.642105263157895,-0.995881383855025,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","150/150","H",3.24545333052325,2.7826871320661e-09,0.546011377839736,5.94392985612077,9.76352440503871,88.06998811648,1.40948247478545,4.51976315688199e-13,12.3448843223466,8.64707452935555,102.96388402837,6.29217184975434e-18,"lineage4","dr_mutations_pyrazinamide","TYR",0,"SAMN02053751","SRR833074_SRR833163","lineage4.3.3","za","South Africa","pnca_p.his71tyr","A","-","HIS","HA71","pnca_complex.pdb"
|
|
"H71Y","L4","PZA","H","H71",71,"Y",1,"MDR","DM","hydrophobic","hydrophobic","basic","neutral","pos","polar",4.184,-1.955,-0.461,-1.77532,-0.84,-0.23,61,80,-1.209,9,9,5,0.0223214285714285,"loop",-0.766666666666667,6.25,0.0017967514733362,25.6733460559796,25.6733459339263,25.6638623299459,74.4270249019608,-26,-6,0,0,-6,0,0,0,0,-2,0,2,-4,0,0,0,0,-8,0,-3,-5,-12,0,-12,-6,-0.495187436676798,-0.119121447028424,-0.34132892409444,-0.143222506393862,-0.0602094240837696,0.642105263157895,-0.995881383855025,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","150/150","H",3.24545333052325,2.7826871320661e-09,0.546011377839736,5.94392985612077,9.76352440503871,88.06998811648,1.40948247478545,4.51976315688199e-13,12.3448843223466,8.64707452935555,102.96388402837,6.29217184975434e-18,"lineage4","dr_mutations_pyrazinamide","TYR",0,"SAMN03648729,SRR2101482","SRR2101482","lineage4.1.2.1","","","pnca_p.his71tyr","A","-","HIS","HA71","pnca_complex.pdb"
|
|
"H71Y","L4","PZA","H","H71",71,"Y",NA,"XDR","DM","hydrophobic","hydrophobic","basic","neutral","pos","polar",4.184,-1.955,-0.461,-1.77532,-0.84,-0.23,61,80,-1.209,9,9,5,0.0223214285714285,"loop",-0.766666666666667,6.25,0.0017967514733362,25.6733460559796,25.6733459339263,25.6638623299459,74.4270249019608,-26,-6,0,0,-6,0,0,0,0,-2,0,2,-4,0,0,0,0,-8,0,-3,-5,-12,0,-12,-6,-0.495187436676798,-0.119121447028424,-0.34132892409444,-0.143222506393862,-0.0602094240837696,0.642105263157895,-0.995881383855025,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","150/150","H",3.24545333052325,2.7826871320661e-09,0.546011377839736,5.94392985612077,9.76352440503871,88.06998811648,1.40948247478545,4.51976315688199e-13,12.3448843223466,8.64707452935555,102.96388402837,6.29217184975434e-18,"lineage4","dr_mutations_pyrazinamide","TYR",0,"ERR2515739","ERR2515739","lineage4.1.2.1","za","South Africa","pnca_p.his71tyr","A","-","HIS","HA71","pnca_complex.pdb"
|
|
"H71Y","L2","PZA","H","H71",71,"Y",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","basic","neutral","pos","polar",4.184,-1.955,-0.461,-1.77532,-0.84,-0.23,61,80,-1.209,9,9,5,0.0223214285714285,"loop",-0.766666666666667,6.25,0.0017967514733362,25.6733460559796,25.6733459339263,25.6638623299459,74.4270249019608,-26,-6,0,0,-6,0,0,0,0,-2,0,2,-4,0,0,0,0,-8,0,-3,-5,-12,0,-12,-6,-0.495187436676798,-0.119121447028424,-0.34132892409444,-0.143222506393862,-0.0602094240837696,0.642105263157895,-0.995881383855025,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","150/150","H",3.24545333052325,2.7826871320661e-09,0.546011377839736,5.94392985612077,9.76352440503871,88.06998811648,1.40948247478545,4.51976315688199e-13,12.3448843223466,8.64707452935555,102.96388402837,6.29217184975434e-18,"lineage2","dr_mutations_pyrazinamide","TYR",0,"OU35-FMRHH6","SRR5341238","lineage2.2.1.1","in","India","pnca_p.his71tyr","A","-","HIS","HA71","pnca_complex.pdb"
|
|
"H71Y","L4","PZA","H","H71",71,"Y",1,"Pre-XDR","DM","hydrophobic","hydrophobic","basic","neutral","pos","polar",4.184,-1.955,-0.461,-1.77532,-0.84,-0.23,61,80,-1.209,9,9,5,0.0223214285714285,"loop",-0.766666666666667,6.25,0.0017967514733362,25.6733460559796,25.6733459339263,25.6638623299459,74.4270249019608,-26,-6,0,0,-6,0,0,0,0,-2,0,2,-4,0,0,0,0,-8,0,-3,-5,-12,0,-12,-6,-0.495187436676798,-0.119121447028424,-0.34132892409444,-0.143222506393862,-0.0602094240837696,0.642105263157895,-0.995881383855025,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","150/150","H",3.24545333052325,2.7826871320661e-09,0.546011377839736,5.94392985612077,9.76352440503871,88.06998811648,1.40948247478545,4.51976315688199e-13,12.3448843223466,8.64707452935555,102.96388402837,6.29217184975434e-18,"lineage4","dr_mutations_pyrazinamide","TYR",0,"ERR2515615","ERR2515615","lineage4.1.1.3","za","South Africa","pnca_p.his71tyr","A","-","HIS","HA71","pnca_complex.pdb"
|
|
"H71Y","L4","PZA","H","H71",71,"Y",1,"MDR","DM","hydrophobic","hydrophobic","basic","neutral","pos","polar",4.184,-1.955,-0.461,-1.77532,-0.84,-0.23,61,80,-1.209,9,9,5,0.0223214285714285,"loop",-0.766666666666667,6.25,0.0017967514733362,25.6733460559796,25.6733459339263,25.6638623299459,74.4270249019608,-26,-6,0,0,-6,0,0,0,0,-2,0,2,-4,0,0,0,0,-8,0,-3,-5,-12,0,-12,-6,-0.495187436676798,-0.119121447028424,-0.34132892409444,-0.143222506393862,-0.0602094240837696,0.642105263157895,-0.995881383855025,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","150/150","H",3.24545333052325,2.7826871320661e-09,0.546011377839736,5.94392985612077,9.76352440503871,88.06998811648,1.40948247478545,4.51976315688199e-13,12.3448843223466,8.64707452935555,102.96388402837,6.29217184975434e-18,"lineage4","dr_mutations_pyrazinamide","TYR",0,"ERR553216","ERR553216","lineage4.1.2.1","sz","Swaziland","pnca_p.his71tyr","A","-","HIS","HA71","pnca_complex.pdb"
|
|
"C72G","LBOV","PZA","C","C72",72,"G",NA,"Other","OM","hydrophobic","hydrophobic","neutral","neutral","non-polar","non-polar",7.053,-0.725,-1.759,1.3326,-1.459,-1.55,54,75,-1.104,9,9,0,0,"loop",1.16666666666667,7.01,NA,NA,NA,NA,NA,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-2,0,0,-2,0,0,3,17,-0.183637284701114,-0.454521963824289,0.0485361927170215,-0.248763853367434,-0.405759162303665,0.568421052631579,-0.909390444810544,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.178,-1.062,"9:9","150/150","G:A:C",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineageBOV","other_mutations_pyrazinamide","GLY",0,"ERR553338","ERR553338","lineageBOV","cg","Congo","pnca_p.cys72gly","A","S","CYS","CA72","pnca_complex.pdb"
|
|
"C72R","L2","PZA","C","C72",72,"R",1,"Pre-XDR","DM","hydrophobic","hydrophilic","neutral","basic","non-polar","pos",7.053,0.152,-1.639,7.93343,-2.368,-1.28,87,91,-1.104,9,9,0,0,"loop",1.16666666666667,7.01,0.0002156101768003,9.70466975178797,9.70465898653054,9.70194990589383,2.29168245016684,-68,-32,0,0,-32,0,0,0,0,-6,0,-6,-2,0,0,0,0,-16,0,-5,-13,-20,0,-8,-12,0.0681614349775784,-0.423514211886305,0.288952789574516,-0.403751065643649,-0.335078534031414,0.91578947368421,-0.909390444810544,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.178,-1.062,"9:9","150/150","G:A:C",2.27260607808817,0.0634455902260893,1.22442760158496,1.8560559033024,0.929172866365108,208.881603005161,0.986980761010679,0.0776844925942494,1.10966566656461,0.504888890842109,570.372842410328,0.130068862702538,"lineage2","dr_mutations_pyrazinamide","ARG",0,"0180X-sc-2011-09-07T13:18:50Z-1276428,ERR067581","ERR067581","lineage2.2.1","ru","Russia,Samara","pnca_p.cys72arg","A","S","CYS","CA72","pnca_complex.pdb"
|
|
"C72R","L4","PZA","C","C72",72,"R",0,"MDR","DM","hydrophobic","hydrophilic","neutral","basic","non-polar","pos",7.053,0.152,-1.639,7.93343,-2.368,-1.28,87,91,-1.104,9,9,0,0,"loop",1.16666666666667,7.01,0.0002156101768003,9.70466975178797,9.70465898653054,9.70194990589383,2.29168245016684,-68,-32,0,0,-32,0,0,0,0,-6,0,-6,-2,0,0,0,0,-16,0,-5,-13,-20,0,-8,-12,0.0681614349775784,-0.423514211886305,0.288952789574516,-0.403751065643649,-0.335078534031414,0.91578947368421,-0.909390444810544,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.178,-1.062,"9:9","150/150","G:A:C",2.27260607808817,0.0634455902260893,1.22442760158496,1.8560559033024,0.929172866365108,208.881603005161,0.986980761010679,0.0776844925942494,1.10966566656461,0.504888890842109,570.372842410328,0.130068862702538,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERR2516672","ERR2516672","lineage4.8","nl","Netherlands","pnca_p.cys72arg","A","S","CYS","CA72","pnca_complex.pdb"
|
|
"C72R","L2","PZA","C","C72",72,"R",NA,"Pre-MDR","DM","hydrophobic","hydrophilic","neutral","basic","non-polar","pos",7.053,0.152,-1.639,7.93343,-2.368,-1.28,87,91,-1.104,9,9,0,0,"loop",1.16666666666667,7.01,0.0002156101768003,9.70466975178797,9.70465898653054,9.70194990589383,2.29168245016684,-68,-32,0,0,-32,0,0,0,0,-6,0,-6,-2,0,0,0,0,-16,0,-5,-13,-20,0,-8,-12,0.0681614349775784,-0.423514211886305,0.288952789574516,-0.403751065643649,-0.335078534031414,0.91578947368421,-0.909390444810544,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.178,-1.062,"9:9","150/150","G:A:C",2.27260607808817,0.0634455902260893,1.22442760158496,1.8560559033024,0.929172866365108,208.881603005161,0.986980761010679,0.0776844925942494,1.10966566656461,0.504888890842109,570.372842410328,0.130068862702538,"lineage2","dr_mutations_pyrazinamide","ARG",0,"SRR5065550","SRR5065550","lineage2.2.1","vn","Vietnam","pnca_p.cys72arg","A","S","CYS","CA72","pnca_complex.pdb"
|
|
"C72R","L2","PZA","C","C72",72,"R",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","neutral","basic","non-polar","pos",7.053,0.152,-1.639,7.93343,-2.368,-1.28,87,91,-1.104,9,9,0,0,"loop",1.16666666666667,7.01,0.0002156101768003,9.70466975178797,9.70465898653054,9.70194990589383,2.29168245016684,-68,-32,0,0,-32,0,0,0,0,-6,0,-6,-2,0,0,0,0,-16,0,-5,-13,-20,0,-8,-12,0.0681614349775784,-0.423514211886305,0.288952789574516,-0.403751065643649,-0.335078534031414,0.91578947368421,-0.909390444810544,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.178,-1.062,"9:9","150/150","G:A:C",2.27260607808817,0.0634455902260893,1.22442760158496,1.8560559033024,0.929172866365108,208.881603005161,0.986980761010679,0.0776844925942494,1.10966566656461,0.504888890842109,570.372842410328,0.130068862702538,"lineage2","dr_mutations_pyrazinamide","ARG",0,"ERR133927,0758A-sc-2012-02-09T18:56:58Z-1355260","ERR133927","lineage2.2.1","ru","Russia","pnca_p.cys72arg","A","S","CYS","CA72","pnca_complex.pdb"
|
|
"C72R","L2","PZA","C","C72",72,"R",NA,"MDR","DM","hydrophobic","hydrophilic","neutral","basic","non-polar","pos",7.053,0.152,-1.639,7.93343,-2.368,-1.28,87,91,-1.104,9,9,0,0,"loop",1.16666666666667,7.01,0.0002156101768003,9.70466975178797,9.70465898653054,9.70194990589383,2.29168245016684,-68,-32,0,0,-32,0,0,0,0,-6,0,-6,-2,0,0,0,0,-16,0,-5,-13,-20,0,-8,-12,0.0681614349775784,-0.423514211886305,0.288952789574516,-0.403751065643649,-0.335078534031414,0.91578947368421,-0.909390444810544,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.178,-1.062,"9:9","150/150","G:A:C",2.27260607808817,0.0634455902260893,1.22442760158496,1.8560559033024,0.929172866365108,208.881603005161,0.986980761010679,0.0776844925942494,1.10966566656461,0.504888890842109,570.372842410328,0.130068862702538,"lineage2","dr_mutations_pyrazinamide","ARG",0,"ETB0072","SRR6257007","lineage2.2.1","ru","Russia:Samara","pnca_p.cys72arg","A","S","CYS","CA72","pnca_complex.pdb"
|
|
"C72R","L2","PZA","C","C72",72,"R",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","neutral","basic","non-polar","pos",7.053,0.152,-1.639,7.93343,-2.368,-1.28,87,91,-1.104,9,9,0,0,"loop",1.16666666666667,7.01,0.0002156101768003,9.70466975178797,9.70465898653054,9.70194990589383,2.29168245016684,-68,-32,0,0,-32,0,0,0,0,-6,0,-6,-2,0,0,0,0,-16,0,-5,-13,-20,0,-8,-12,0.0681614349775784,-0.423514211886305,0.288952789574516,-0.403751065643649,-0.335078534031414,0.91578947368421,-0.909390444810544,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.178,-1.062,"9:9","150/150","G:A:C",2.27260607808817,0.0634455902260893,1.22442760158496,1.8560559033024,0.929172866365108,208.881603005161,0.986980761010679,0.0776844925942494,1.10966566656461,0.504888890842109,570.372842410328,0.130068862702538,"lineage2","dr_mutations_pyrazinamide","ARG",0,"BGI_XZ06050,SRR671839","SRR671839","lineage2.2.1","cn","China","pnca_p.cys72arg","A","S","CYS","CA72","pnca_complex.pdb"
|
|
"C72R","L2","PZA","C","C72",72,"R",1,"XDR","DM","hydrophobic","hydrophilic","neutral","basic","non-polar","pos",7.053,0.152,-1.639,7.93343,-2.368,-1.28,87,91,-1.104,9,9,0,0,"loop",1.16666666666667,7.01,0.0002156101768003,9.70466975178797,9.70465898653054,9.70194990589383,2.29168245016684,-68,-32,0,0,-32,0,0,0,0,-6,0,-6,-2,0,0,0,0,-16,0,-5,-13,-20,0,-8,-12,0.0681614349775784,-0.423514211886305,0.288952789574516,-0.403751065643649,-0.335078534031414,0.91578947368421,-0.909390444810544,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.178,-1.062,"9:9","150/150","G:A:C",2.27260607808817,0.0634455902260893,1.22442760158496,1.8560559033024,0.929172866365108,208.881603005161,0.986980761010679,0.0776844925942494,1.10966566656461,0.504888890842109,570.372842410328,0.130068862702538,"lineage2","dr_mutations_pyrazinamide","ARG",0,"ERS457650","ERR551862_ERR551861","lineage2.2.1","uz","Nukus","pnca_p.cys72arg","A","S","CYS","CA72","pnca_complex.pdb"
|
|
"C72R","L2","PZA","C","C72",72,"R",NA,"Pre-MDR","DM","hydrophobic","hydrophilic","neutral","basic","non-polar","pos",7.053,0.152,-1.639,7.93343,-2.368,-1.28,87,91,-1.104,9,9,0,0,"loop",1.16666666666667,7.01,0.0002156101768003,9.70466975178797,9.70465898653054,9.70194990589383,2.29168245016684,-68,-32,0,0,-32,0,0,0,0,-6,0,-6,-2,0,0,0,0,-16,0,-5,-13,-20,0,-8,-12,0.0681614349775784,-0.423514211886305,0.288952789574516,-0.403751065643649,-0.335078534031414,0.91578947368421,-0.909390444810544,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.178,-1.062,"9:9","150/150","G:A:C",2.27260607808817,0.0634455902260893,1.22442760158496,1.8560559033024,0.929172866365108,208.881603005161,0.986980761010679,0.0776844925942494,1.10966566656461,0.504888890842109,570.372842410328,0.130068862702538,"lineage2","dr_mutations_pyrazinamide","ARG",0,"SRR5073822","SRR5073822","lineage2.1","vn","Vietnam","pnca_p.cys72arg","A","S","CYS","CA72","pnca_complex.pdb"
|
|
"C72R","L4","PZA","C","C72",72,"R",NA,"MDR","DM","hydrophobic","hydrophilic","neutral","basic","non-polar","pos",7.053,0.152,-1.639,7.93343,-2.368,-1.28,87,91,-1.104,9,9,0,0,"loop",1.16666666666667,7.01,0.0002156101768003,9.70466975178797,9.70465898653054,9.70194990589383,2.29168245016684,-68,-32,0,0,-32,0,0,0,0,-6,0,-6,-2,0,0,0,0,-16,0,-5,-13,-20,0,-8,-12,0.0681614349775784,-0.423514211886305,0.288952789574516,-0.403751065643649,-0.335078534031414,0.91578947368421,-0.909390444810544,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.178,-1.062,"9:9","150/150","G:A:C",2.27260607808817,0.0634455902260893,1.22442760158496,1.8560559033024,0.929172866365108,208.881603005161,0.986980761010679,0.0776844925942494,1.10966566656461,0.504888890842109,570.372842410328,0.130068862702538,"lineage4","dr_mutations_pyrazinamide","ARG",0,"OU59-FMR370F","SRR5341218","lineage4.3.3","in","India","pnca_p.cys72arg","A","S","CYS","CA72","pnca_complex.pdb"
|
|
"C72R","L4","PZA","C","C72",72,"R",NA,"Pre-MDR","DM","hydrophobic","hydrophilic","neutral","basic","non-polar","pos",7.053,0.152,-1.639,7.93343,-2.368,-1.28,87,91,-1.104,9,9,0,0,"loop",1.16666666666667,7.01,0.0002156101768003,9.70466975178797,9.70465898653054,9.70194990589383,2.29168245016684,-68,-32,0,0,-32,0,0,0,0,-6,0,-6,-2,0,0,0,0,-16,0,-5,-13,-20,0,-8,-12,0.0681614349775784,-0.423514211886305,0.288952789574516,-0.403751065643649,-0.335078534031414,0.91578947368421,-0.909390444810544,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.178,-1.062,"9:9","150/150","G:A:C",2.27260607808817,0.0634455902260893,1.22442760158496,1.8560559033024,0.929172866365108,208.881603005161,0.986980761010679,0.0776844925942494,1.10966566656461,0.504888890842109,570.372842410328,0.130068862702538,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERR1035291","ERR1035291","lineage4.3.4.2","br","Brazil","pnca_p.cys72arg","A","S","CYS","CA72","pnca_complex.pdb"
|
|
"C72R","L2","PZA","C","C72",72,"R",NA,"MDR","DM","hydrophobic","hydrophilic","neutral","basic","non-polar","pos",7.053,0.152,-1.639,7.93343,-2.368,-1.28,87,91,-1.104,9,9,0,0,"loop",1.16666666666667,7.01,0.0002156101768003,9.70466975178797,9.70465898653054,9.70194990589383,2.29168245016684,-68,-32,0,0,-32,0,0,0,0,-6,0,-6,-2,0,0,0,0,-16,0,-5,-13,-20,0,-8,-12,0.0681614349775784,-0.423514211886305,0.288952789574516,-0.403751065643649,-0.335078534031414,0.91578947368421,-0.909390444810544,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.178,-1.062,"9:9","150/150","G:A:C",2.27260607808817,0.0634455902260893,1.22442760158496,1.8560559033024,0.929172866365108,208.881603005161,0.986980761010679,0.0776844925942494,1.10966566656461,0.504888890842109,570.372842410328,0.130068862702538,"lineage2","dr_mutations_pyrazinamide","ARG",0,"ERR1035088","ERR1035088","lineage2.2.1.1","vn","Vietnam","pnca_p.cys72arg","A","S","CYS","CA72","pnca_complex.pdb"
|
|
"C72W","L4","PZA","C","C72",72,"W",1,"MDR","DM","hydrophobic","hydrophobic","neutral","non-polar","non-polar","non-polar",7.053,0.265,-1.725,27.4558,-1.622,-1.13,85,91,-1.104,9,9,0,0,"loop",1.16666666666667,7.01,0.0001437401178668,19.411022297013,511754.463552333,Inf,4.73122070382274,-46,0,0,0,0,0,0,0,0,-2,0,0,-2,0,0,0,0,-12,0,-12,-6,-16,0,-14,-8,0.118834080717489,-0.445736434108527,1,-0.276555839727195,-0.295811518324607,0.894736842105263,-0.909390444810544,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.178,-1.062,"9:9","150/150","G:A:C",13.14560022562,0.924803768446981,139.277183326528,0.0943844491369478,0.0001628371344461,NA,1.28804840845689,0.0292235860951597,1.53426649183163,0.91081598550184,Inf,0.0296198560706035,"lineage4","dr_mutations_pyrazinamide","TRP",0,"SAMN10961405","SRR8651625","lineage4.4.2","cn","China:Wenzhou","pnca_p.cys72trp","A","S","CYS","CA72","pnca_complex.pdb"
|
|
"C72W","L4","PZA","C","C72",72,"W",1,"MDR","DM","hydrophobic","hydrophobic","neutral","non-polar","non-polar","non-polar",7.053,0.265,-1.725,27.4558,-1.622,-1.13,85,91,-1.104,9,9,0,0,"loop",1.16666666666667,7.01,0.0001437401178668,19.411022297013,511754.463552333,Inf,4.73122070382274,-46,0,0,0,0,0,0,0,0,-2,0,0,-2,0,0,0,0,-12,0,-12,-6,-16,0,-14,-8,0.118834080717489,-0.445736434108527,1,-0.276555839727195,-0.295811518324607,0.894736842105263,-0.909390444810544,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.178,-1.062,"9:9","150/150","G:A:C",13.14560022562,0.924803768446981,139.277183326528,0.0943844491369478,0.0001628371344461,NA,1.28804840845689,0.0292235860951597,1.53426649183163,0.91081598550184,Inf,0.0296198560706035,"lineage4","dr_mutations_pyrazinamide","TRP",0,"SAMN10961322","SRR8651643","lineage4.4.2","cn","China:Wenzhou","pnca_p.cys72trp","A","S","CYS","CA72","pnca_complex.pdb"
|
|
"C72Y","L4","PZA","C","C72",72,"Y",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","neutral","neutral","non-polar","polar",7.053,0.154,-1.564,15.4245,-1.249,-1.05,83,91,-1.104,9,9,0,0,"loop",1.16666666666667,7.01,7.18700589334483e-05,9.70142977291842,188179.92626441,Inf,0.763784339928386,-46,-12,0,0,-12,0,0,0,0,-2,0,-2,0,0,0,0,0,-15,0,-4,-13,-18,0,-16,-14,0.0690582959641255,-0.404134366925065,0.561793865048551,-0.212958226768968,-0.274869109947644,0.873684210526316,-0.909390444810544,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.178,-1.062,"9:9","150/150","G:A:C",12.1451538387253,0.919026337424193,119.46804443616,0.101660271548307,5.0115366606943e-06,NA,0.986835744238421,0.170978870202674,0.767057556984365,0.124324963210678,Inf,0.382146811758261,"lineage4","dr_mutations_pyrazinamide","TYR",0,"ERR1035034","ERR1035034","lineage4.3.4.2.1","za","South Africa","pnca_p.cys72tyr","A","S","CYS","CA72","pnca_complex.pdb"
|
|
"C72Y","L4","PZA","C","C72",72,"Y",1,"Pre-XDR","DM","hydrophobic","hydrophobic","neutral","neutral","non-polar","polar",7.053,0.154,-1.564,15.4245,-1.249,-1.05,83,91,-1.104,9,9,0,0,"loop",1.16666666666667,7.01,7.18700589334483e-05,9.70142977291842,188179.92626441,Inf,0.763784339928386,-46,-12,0,0,-12,0,0,0,0,-2,0,-2,0,0,0,0,0,-15,0,-4,-13,-18,0,-16,-14,0.0690582959641255,-0.404134366925065,0.561793865048551,-0.212958226768968,-0.274869109947644,0.873684210526316,-0.909390444810544,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.178,-1.062,"9:9","150/150","G:A:C",12.1451538387253,0.919026337424193,119.46804443616,0.101660271548307,5.0115366606943e-06,NA,0.986835744238421,0.170978870202674,0.767057556984365,0.124324963210678,Inf,0.382146811758261,"lineage4","dr_mutations_pyrazinamide","TYR",0,"SAMN10961398","SRR8651633","lineage4.4.2","cn","China:Wenzhou","pnca_p.cys72tyr","A","S","CYS","CA72","pnca_complex.pdb"
|
|
"C72Y","L2","PZA","C","C72",72,"Y",NA,"XDR","DM","hydrophobic","hydrophobic","neutral","neutral","non-polar","polar",7.053,0.154,-1.564,15.4245,-1.249,-1.05,83,91,-1.104,9,9,0,0,"loop",1.16666666666667,7.01,7.18700589334483e-05,9.70142977291842,188179.92626441,Inf,0.763784339928386,-46,-12,0,0,-12,0,0,0,0,-2,0,-2,0,0,0,0,0,-15,0,-4,-13,-18,0,-16,-14,0.0690582959641255,-0.404134366925065,0.561793865048551,-0.212958226768968,-0.274869109947644,0.873684210526316,-0.909390444810544,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.178,-1.062,"9:9","150/150","G:A:C",12.1451538387253,0.919026337424193,119.46804443616,0.101660271548307,5.0115366606943e-06,NA,0.986835744238421,0.170978870202674,0.767057556984365,0.124324963210678,Inf,0.382146811758261,"lineage2","dr_mutations_pyrazinamide","TYR",0,"BGI_GuangZ8,SRR671726","SRR671726","lineage2.2.1","cn","China","pnca_p.cys72tyr","A","S","CYS","CA72","pnca_complex.pdb"
|
|
"C72Y","L2","PZA","C","C72",72,"Y",NA,"Pre-MDR","DM","hydrophobic","hydrophobic","neutral","neutral","non-polar","polar",7.053,0.154,-1.564,15.4245,-1.249,-1.05,83,91,-1.104,9,9,0,0,"loop",1.16666666666667,7.01,7.18700589334483e-05,9.70142977291842,188179.92626441,Inf,0.763784339928386,-46,-12,0,0,-12,0,0,0,0,-2,0,-2,0,0,0,0,0,-15,0,-4,-13,-18,0,-16,-14,0.0690582959641255,-0.404134366925065,0.561793865048551,-0.212958226768968,-0.274869109947644,0.873684210526316,-0.909390444810544,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.178,-1.062,"9:9","150/150","G:A:C",12.1451538387253,0.919026337424193,119.46804443616,0.101660271548307,5.0115366606943e-06,NA,0.986835744238421,0.170978870202674,0.767057556984365,0.124324963210678,Inf,0.382146811758261,"lineage2","dr_mutations_pyrazinamide","TYR",0,"SRR5067696","SRR5067696","lineage2.2.1","vn","Vietnam","pnca_p.cys72tyr","A","S","CYS","CA72","pnca_complex.pdb"
|
|
"C72Y","L4","PZA","C","C72",72,"Y",NA,"MDR","DM","hydrophobic","hydrophobic","neutral","neutral","non-polar","polar",7.053,0.154,-1.564,15.4245,-1.249,-1.05,83,91,-1.104,9,9,0,0,"loop",1.16666666666667,7.01,7.18700589334483e-05,9.70142977291842,188179.92626441,Inf,0.763784339928386,-46,-12,0,0,-12,0,0,0,0,-2,0,-2,0,0,0,0,0,-15,0,-4,-13,-18,0,-16,-14,0.0690582959641255,-0.404134366925065,0.561793865048551,-0.212958226768968,-0.274869109947644,0.873684210526316,-0.909390444810544,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.178,-1.062,"9:9","150/150","G:A:C",12.1451538387253,0.919026337424193,119.46804443616,0.101660271548307,5.0115366606943e-06,NA,0.986835744238421,0.170978870202674,0.767057556984365,0.124324963210678,Inf,0.382146811758261,"lineage4","dr_mutations_pyrazinamide","TYR",0,"ERR1035338","ERR1035338","lineage4.1.1.3","br","Brazil","pnca_p.cys72tyr","A","S","CYS","CA72","pnca_complex.pdb"
|
|
"C72Y","L3","PZA","C","C72",72,"Y",NA,"MDR","DM","hydrophobic","hydrophobic","neutral","neutral","non-polar","polar",7.053,0.154,-1.564,15.4245,-1.249,-1.05,83,91,-1.104,9,9,0,0,"loop",1.16666666666667,7.01,7.18700589334483e-05,9.70142977291842,188179.92626441,Inf,0.763784339928386,-46,-12,0,0,-12,0,0,0,0,-2,0,-2,0,0,0,0,0,-15,0,-4,-13,-18,0,-16,-14,0.0690582959641255,-0.404134366925065,0.561793865048551,-0.212958226768968,-0.274869109947644,0.873684210526316,-0.909390444810544,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.178,-1.062,"9:9","150/150","G:A:C",12.1451538387253,0.919026337424193,119.46804443616,0.101660271548307,5.0115366606943e-06,NA,0.986835744238421,0.170978870202674,0.767057556984365,0.124324963210678,Inf,0.382146811758261,"lineage3","dr_mutations_pyrazinamide","TYR",0,"ERR2510637","ERR2510637","lineage3.1.2","pk","Pakistan","pnca_p.cys72tyr","A","S","CYS","CA72","pnca_complex.pdb"
|
|
"V73D","L2","PZA","V","V73",73,"D",NA,"MDR","OM","hydrophobic","hydrophilic","non-polar","acidic","non-polar","neg",10.768,1.153,-1.148,1.11169,-2.613,-1.37,87,91,-0.743,8,8,46,0.264367816091954,"strand",1.96666666666667,4.66,NA,NA,NA,NA,NA,-6,-50,0,0,-50,0,0,0,0,0,0,0,0,0,0,0,0,-2,0,-4,2,2,0,2,-2,0.517040358744395,-0.296640826873385,0.0404901696544992,-0.445524296675192,-0.358638743455497,0.91578947368421,-0.612026359143328,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.872,-0.674,"8:7","150/150","I:R:K:L:V:E:T:M",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage2","other_mutations_pyrazinamide","ASP",0,"BGI_SH337,SRR671818","SRR671818","lineage2.2.1","cn","China","pnca_p.val73asp","A","B","VAL","VA73","pnca_complex.pdb"
|
|
"T76I","L2","PZA","T","T76",76,"I",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","neutral","non-polar","polar","non-polar",14.032,-0.319,0.311,-0.781308,-0.733,-0.73,69,80,-0.548,7,7,56,0.325581395348837,"loop",-0.9,3.94,0.0002156101768003,29.1287878787879,511969.848429101,Inf,9.2872640727157,-10,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,-6,0,-6,0,0,0,0,-4,-0.0808004052684903,0.264455782312925,-0.150216873029301,-0.124978687127025,-0.19109947643979,0.726315789473684,-0.451400329489292,"Destabilising","Stabilising","Stabilising","Destabilising","Destabilising","effect",-0.674,-0.485,"7:7","150/150","Q:T:S:D",13.1460210125007,0.907969111549626,113.719344731963,0.115600569485217,0.183926936276972,NA,1.4643224129316,0.0049931328456149,2.3016268790981,2.00455510251839,Inf,0.0023075254069185,"lineage2","dr_mutations_pyrazinamide","ILE",0,"SAMN03653232,SRS935975","SRR2024927","lineage2.2.1","cn","China","pnca_p.thr76ile","A","S","THR","TA76","pnca_complex.pdb"
|
|
"T76I","L2","PZA","T","T76",76,"I",1,"MDR","DM","hydrophobic","hydrophobic","neutral","non-polar","polar","non-polar",14.032,-0.319,0.311,-0.781308,-0.733,-0.73,69,80,-0.548,7,7,56,0.325581395348837,"loop",-0.9,3.94,0.0002156101768003,29.1287878787879,511969.848429101,Inf,9.2872640727157,-10,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,-6,0,-6,0,0,0,0,-4,-0.0808004052684903,0.264455782312925,-0.150216873029301,-0.124978687127025,-0.19109947643979,0.726315789473684,-0.451400329489292,"Destabilising","Stabilising","Stabilising","Destabilising","Destabilising","effect",-0.674,-0.485,"7:7","150/150","Q:T:S:D",13.1460210125007,0.907969111549626,113.719344731963,0.115600569485217,0.183926936276972,NA,1.4643224129316,0.0049931328456149,2.3016268790981,2.00455510251839,Inf,0.0023075254069185,"lineage2","dr_mutations_pyrazinamide","ILE",0,"ERR3335763","ERR3335763","lineage2.2.1","pk","Pakistan","pnca_p.thr76ile","A","S","THR","TA76","pnca_complex.pdb"
|
|
"T76I","L4","PZA","T","T76",76,"I",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","neutral","non-polar","polar","non-polar",14.032,-0.319,0.311,-0.781308,-0.733,-0.73,69,80,-0.548,7,7,56,0.325581395348837,"loop",-0.9,3.94,0.0002156101768003,29.1287878787879,511969.848429101,Inf,9.2872640727157,-10,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,-6,0,-6,0,0,0,0,-4,-0.0808004052684903,0.264455782312925,-0.150216873029301,-0.124978687127025,-0.19109947643979,0.726315789473684,-0.451400329489292,"Destabilising","Stabilising","Stabilising","Destabilising","Destabilising","effect",-0.674,-0.485,"7:7","150/150","Q:T:S:D",13.1460210125007,0.907969111549626,113.719344731963,0.115600569485217,0.183926936276972,NA,1.4643224129316,0.0049931328456149,2.3016268790981,2.00455510251839,Inf,0.0023075254069185,"lineage4","dr_mutations_pyrazinamide","ILE",0,"ERR1034807","ERR1034807","lineage4.1.2.1","pt","Portugal","pnca_p.thr76ile","A","S","THR","TA76","pnca_complex.pdb"
|
|
"T76I","L3","PZA","T","T76",76,"I",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","neutral","non-polar","polar","non-polar",14.032,-0.319,0.311,-0.781308,-0.733,-0.73,69,80,-0.548,7,7,56,0.325581395348837,"loop",-0.9,3.94,0.0002156101768003,29.1287878787879,511969.848429101,Inf,9.2872640727157,-10,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,-6,0,-6,0,0,0,0,-4,-0.0808004052684903,0.264455782312925,-0.150216873029301,-0.124978687127025,-0.19109947643979,0.726315789473684,-0.451400329489292,"Destabilising","Stabilising","Stabilising","Destabilising","Destabilising","effect",-0.674,-0.485,"7:7","150/150","Q:T:S:D",13.1460210125007,0.907969111549626,113.719344731963,0.115600569485217,0.183926936276972,NA,1.4643224129316,0.0049931328456149,2.3016268790981,2.00455510251839,Inf,0.0023075254069185,"lineage3","dr_mutations_pyrazinamide","ILE",0,"ERR2510642","ERR2510642","lineage3","pk","Pakistan","pnca_p.thr76ile","A","S","THR","TA76","pnca_complex.pdb"
|
|
"T76I","L1","PZA","T","T76",76,"I",1,"MDR","DM","hydrophobic","hydrophobic","neutral","non-polar","polar","non-polar",14.032,-0.319,0.311,-0.781308,-0.733,-0.73,69,80,-0.548,7,7,56,0.325581395348837,"loop",-0.9,3.94,0.0002156101768003,29.1287878787879,511969.848429101,Inf,9.2872640727157,-10,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,-6,0,-6,0,0,0,0,-4,-0.0808004052684903,0.264455782312925,-0.150216873029301,-0.124978687127025,-0.19109947643979,0.726315789473684,-0.451400329489292,"Destabilising","Stabilising","Stabilising","Destabilising","Destabilising","effect",-0.674,-0.485,"7:7","150/150","Q:T:S:D",13.1460210125007,0.907969111549626,113.719344731963,0.115600569485217,0.183926936276972,NA,1.4643224129316,0.0049931328456149,2.3016268790981,2.00455510251839,Inf,0.0023075254069185,"lineage1","dr_mutations_pyrazinamide","ILE",0,"ERS2592811","ERR2677468","lineage1.1.2","de","Germany","pnca_p.thr76ile","A","S","THR","TA76","pnca_complex.pdb"
|
|
"T76I","L2","PZA","T","T76",76,"I",NA,"MDR","DM","hydrophobic","hydrophobic","neutral","non-polar","polar","non-polar",14.032,-0.319,0.311,-0.781308,-0.733,-0.73,69,80,-0.548,7,7,56,0.325581395348837,"loop",-0.9,3.94,0.0002156101768003,29.1287878787879,511969.848429101,Inf,9.2872640727157,-10,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,-6,0,-6,0,0,0,0,-4,-0.0808004052684903,0.264455782312925,-0.150216873029301,-0.124978687127025,-0.19109947643979,0.726315789473684,-0.451400329489292,"Destabilising","Stabilising","Stabilising","Destabilising","Destabilising","effect",-0.674,-0.485,"7:7","150/150","Q:T:S:D",13.1460210125007,0.907969111549626,113.719344731963,0.115600569485217,0.183926936276972,NA,1.4643224129316,0.0049931328456149,2.3016268790981,2.00455510251839,Inf,0.0023075254069185,"lineage2","dr_mutations_pyrazinamide","ILE",0,"SAMN07236382,SRR5709808","SRR5709808","lineage2.2.1","th","Thailand","pnca_p.thr76ile","A","S","THR","TA76","pnca_complex.pdb"
|
|
"T76I","L4","PZA","T","T76",76,"I",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","neutral","non-polar","polar","non-polar",14.032,-0.319,0.311,-0.781308,-0.733,-0.73,69,80,-0.548,7,7,56,0.325581395348837,"loop",-0.9,3.94,0.0002156101768003,29.1287878787879,511969.848429101,Inf,9.2872640727157,-10,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,-6,0,-6,0,0,0,0,-4,-0.0808004052684903,0.264455782312925,-0.150216873029301,-0.124978687127025,-0.19109947643979,0.726315789473684,-0.451400329489292,"Destabilising","Stabilising","Stabilising","Destabilising","Destabilising","effect",-0.674,-0.485,"7:7","150/150","Q:T:S:D",13.1460210125007,0.907969111549626,113.719344731963,0.115600569485217,0.183926936276972,NA,1.4643224129316,0.0049931328456149,2.3016268790981,2.00455510251839,Inf,0.0023075254069185,"lineage4","dr_mutations_pyrazinamide","ILE",0,"ERR1034806","ERR1034806","lineage4.1.2.1","pt","Portugal","pnca_p.thr76ile","A","S","THR","TA76","pnca_complex.pdb"
|
|
"T76I","L2","PZA","T","T76",76,"I",1,"MDR","DM","hydrophobic","hydrophobic","neutral","non-polar","polar","non-polar",14.032,-0.319,0.311,-0.781308,-0.733,-0.73,69,80,-0.548,7,7,56,0.325581395348837,"loop",-0.9,3.94,0.0002156101768003,29.1287878787879,511969.848429101,Inf,9.2872640727157,-10,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,-6,0,-6,0,0,0,0,-4,-0.0808004052684903,0.264455782312925,-0.150216873029301,-0.124978687127025,-0.19109947643979,0.726315789473684,-0.451400329489292,"Destabilising","Stabilising","Stabilising","Destabilising","Destabilising","effect",-0.674,-0.485,"7:7","150/150","Q:T:S:D",13.1460210125007,0.907969111549626,113.719344731963,0.115600569485217,0.183926936276972,NA,1.4643224129316,0.0049931328456149,2.3016268790981,2.00455510251839,Inf,0.0023075254069185,"lineage2","dr_mutations_pyrazinamide","ILE",0,"SAMEA2534129,ERR551701,ERS457531","ERR551701","lineage2.2.1","uz","Nukus","pnca_p.thr76ile","A","S","THR","TA76","pnca_complex.pdb"
|
|
"T76I","L4","PZA","T","T76",76,"I",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","neutral","non-polar","polar","non-polar",14.032,-0.319,0.311,-0.781308,-0.733,-0.73,69,80,-0.548,7,7,56,0.325581395348837,"loop",-0.9,3.94,0.0002156101768003,29.1287878787879,511969.848429101,Inf,9.2872640727157,-10,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,-6,0,-6,0,0,0,0,-4,-0.0808004052684903,0.264455782312925,-0.150216873029301,-0.124978687127025,-0.19109947643979,0.726315789473684,-0.451400329489292,"Destabilising","Stabilising","Stabilising","Destabilising","Destabilising","effect",-0.674,-0.485,"7:7","150/150","Q:T:S:D",13.1460210125007,0.907969111549626,113.719344731963,0.115600569485217,0.183926936276972,NA,1.4643224129316,0.0049931328456149,2.3016268790981,2.00455510251839,Inf,0.0023075254069185,"lineage4","dr_mutations_pyrazinamide","ILE",0,"ERR1034808","ERR1034808","lineage4.1.2.1","pt","Portugal","pnca_p.thr76ile","A","S","THR","TA76","pnca_complex.pdb"
|
|
"T76I","L2","PZA","T","T76",76,"I",NA,"XDR","DM","hydrophobic","hydrophobic","neutral","non-polar","polar","non-polar",14.032,-0.319,0.311,-0.781308,-0.733,-0.73,69,80,-0.548,7,7,56,0.325581395348837,"loop",-0.9,3.94,0.0002156101768003,29.1287878787879,511969.848429101,Inf,9.2872640727157,-10,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,-6,0,-6,0,0,0,0,-4,-0.0808004052684903,0.264455782312925,-0.150216873029301,-0.124978687127025,-0.19109947643979,0.726315789473684,-0.451400329489292,"Destabilising","Stabilising","Stabilising","Destabilising","Destabilising","effect",-0.674,-0.485,"7:7","150/150","Q:T:S:D",13.1460210125007,0.907969111549626,113.719344731963,0.115600569485217,0.183926936276972,NA,1.4643224129316,0.0049931328456149,2.3016268790981,2.00455510251839,Inf,0.0023075254069185,"lineage2","dr_mutations_pyrazinamide","ILE",0,"SAMN07236514,SRR5709935","SRR5709935","lineage2.2.1","th","Thailand","pnca_p.thr76ile","A","S","THR","TA76","pnca_complex.pdb"
|
|
"T76I","L2","PZA","T","T76",76,"I",NA,"MDR","DM","hydrophobic","hydrophobic","neutral","non-polar","polar","non-polar",14.032,-0.319,0.311,-0.781308,-0.733,-0.73,69,80,-0.548,7,7,56,0.325581395348837,"loop",-0.9,3.94,0.0002156101768003,29.1287878787879,511969.848429101,Inf,9.2872640727157,-10,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,-6,0,-6,0,0,0,0,-4,-0.0808004052684903,0.264455782312925,-0.150216873029301,-0.124978687127025,-0.19109947643979,0.726315789473684,-0.451400329489292,"Destabilising","Stabilising","Stabilising","Destabilising","Destabilising","effect",-0.674,-0.485,"7:7","150/150","Q:T:S:D",13.1460210125007,0.907969111549626,113.719344731963,0.115600569485217,0.183926936276972,NA,1.4643224129316,0.0049931328456149,2.3016268790981,2.00455510251839,Inf,0.0023075254069185,"lineage2","dr_mutations_pyrazinamide","ILE",0,"SRR5709875","SRR5709875","lineage2.2.1","th","Thailand","pnca_p.thr76ile","A","S","THR","TA76","pnca_complex.pdb"
|
|
"T76I","L4","PZA","T","T76",76,"I",NA,"MDR","DM","hydrophobic","hydrophobic","neutral","non-polar","polar","non-polar",14.032,-0.319,0.311,-0.781308,-0.733,-0.73,69,80,-0.548,7,7,56,0.325581395348837,"loop",-0.9,3.94,0.0002156101768003,29.1287878787879,511969.848429101,Inf,9.2872640727157,-10,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,-6,0,-6,0,0,0,0,-4,-0.0808004052684903,0.264455782312925,-0.150216873029301,-0.124978687127025,-0.19109947643979,0.726315789473684,-0.451400329489292,"Destabilising","Stabilising","Stabilising","Destabilising","Destabilising","effect",-0.674,-0.485,"7:7","150/150","Q:T:S:D",13.1460210125007,0.907969111549626,113.719344731963,0.115600569485217,0.183926936276972,NA,1.4643224129316,0.0049931328456149,2.3016268790981,2.00455510251839,Inf,0.0023075254069185,"lineage4","dr_mutations_pyrazinamide","ILE",0,"ERR1035346","ERR1035346","lineage4.1.2.1","br","Brazil","pnca_p.thr76ile","A","S","THR","TA76","pnca_complex.pdb"
|
|
"T76P","L4","PZA","T","T76",76,"P",NA,"MDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",14.032,-0.382,-0.519,1.15155,-1.623,-0.09,78,85,-0.548,7,7,56,0.325581395348837,"loop",-0.9,3.94,0.0017248814144027,24.4404408647732,24.4404407276145,24.4312693653994,69.8031277140286,0,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,-4,2,-6,-2,4,0,2,0,-0.096757852077001,-0.134108527131783,0.0419419576191552,-0.276726342710997,-0.0235602094240837,0.821052631578947,-0.451400329489292,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.674,-0.485,"7:7","150/150","Q:T:S:D",3.19623916718558,5.52153426461584e-09,0.548179859875324,5.83063954212496,9.23910743126347,84.0861153416749,1.38810903558899,2.23953024381857e-12,11.6498430682339,8.17279939949528,98.407580019827,6.55288933297668e-17,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR1035324","ERR1035324","lineage4.6","br","Brazil","pnca_p.thr76pro","A","S","THR","TA76","pnca_complex.pdb"
|
|
"T76P","L2","PZA","T","T76",76,"P",1,"MDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",14.032,-0.382,-0.519,1.15155,-1.623,-0.09,78,85,-0.548,7,7,56,0.325581395348837,"loop",-0.9,3.94,0.0017248814144027,24.4404408647732,24.4404407276145,24.4312693653994,69.8031277140286,0,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,-4,2,-6,-2,4,0,2,0,-0.096757852077001,-0.134108527131783,0.0419419576191552,-0.276726342710997,-0.0235602094240837,0.821052631578947,-0.451400329489292,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.674,-0.485,"7:7","150/150","Q:T:S:D",3.19623916718558,5.52153426461584e-09,0.548179859875324,5.83063954212496,9.23910743126347,84.0861153416749,1.38810903558899,2.23953024381857e-12,11.6498430682339,8.17279939949528,98.407580019827,6.55288933297668e-17,"lineage2","dr_mutations_pyrazinamide","PRO",0,"ERR551212","ERR551212","lineage2.2.1","ru","Russia","pnca_p.thr76pro","A","S","THR","TA76","pnca_complex.pdb"
|
|
"T76P","L2","PZA","T","T76",76,"P",1,"MDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",14.032,-0.382,-0.519,1.15155,-1.623,-0.09,78,85,-0.548,7,7,56,0.325581395348837,"loop",-0.9,3.94,0.0017248814144027,24.4404408647732,24.4404407276145,24.4312693653994,69.8031277140286,0,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,-4,2,-6,-2,4,0,2,0,-0.096757852077001,-0.134108527131783,0.0419419576191552,-0.276726342710997,-0.0235602094240837,0.821052631578947,-0.451400329489292,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.674,-0.485,"7:7","150/150","Q:T:S:D",3.19623916718558,5.52153426461584e-09,0.548179859875324,5.83063954212496,9.23910743126347,84.0861153416749,1.38810903558899,2.23953024381857e-12,11.6498430682339,8.17279939949528,98.407580019827,6.55288933297668e-17,"lineage2","dr_mutations_pyrazinamide","PRO",0,"ERR2516459","ERR2516459","lineage2.2.1","nl","Netherlands","pnca_p.thr76pro","A","S","THR","TA76","pnca_complex.pdb"
|
|
"T76P","L4","PZA","T","T76",76,"P",NA,"MDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",14.032,-0.382,-0.519,1.15155,-1.623,-0.09,78,85,-0.548,7,7,56,0.325581395348837,"loop",-0.9,3.94,0.0017248814144027,24.4404408647732,24.4404407276145,24.4312693653994,69.8031277140286,0,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,-4,2,-6,-2,4,0,2,0,-0.096757852077001,-0.134108527131783,0.0419419576191552,-0.276726342710997,-0.0235602094240837,0.821052631578947,-0.451400329489292,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.674,-0.485,"7:7","150/150","Q:T:S:D",3.19623916718558,5.52153426461584e-09,0.548179859875324,5.83063954212496,9.23910743126347,84.0861153416749,1.38810903558899,2.23953024381857e-12,11.6498430682339,8.17279939949528,98.407580019827,6.55288933297668e-17,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR2707131","ERR2707131","lineage4.3.4.1","cd","Democratic Republic of Congo","pnca_p.thr76pro","A","S","THR","TA76","pnca_complex.pdb"
|
|
"T76P","L4","PZA","T","T76",76,"P",NA,"MDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",14.032,-0.382,-0.519,1.15155,-1.623,-0.09,78,85,-0.548,7,7,56,0.325581395348837,"loop",-0.9,3.94,0.0017248814144027,24.4404408647732,24.4404407276145,24.4312693653994,69.8031277140286,0,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,-4,2,-6,-2,4,0,2,0,-0.096757852077001,-0.134108527131783,0.0419419576191552,-0.276726342710997,-0.0235602094240837,0.821052631578947,-0.451400329489292,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.674,-0.485,"7:7","150/150","Q:T:S:D",3.19623916718558,5.52153426461584e-09,0.548179859875324,5.83063954212496,9.23910743126347,84.0861153416749,1.38810903558899,2.23953024381857e-12,11.6498430682339,8.17279939949528,98.407580019827,6.55288933297668e-17,"lineage4","dr_mutations_pyrazinamide","PRO",0,"SAMN02584629","SRR1166307_SRR1169085","lineage4.3.3","md","Moldova","pnca_p.thr76pro","A","S","THR","TA76","pnca_complex.pdb"
|
|
"T76P","L4","PZA","T","T76",76,"P",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",14.032,-0.382,-0.519,1.15155,-1.623,-0.09,78,85,-0.548,7,7,56,0.325581395348837,"loop",-0.9,3.94,0.0017248814144027,24.4404408647732,24.4404407276145,24.4312693653994,69.8031277140286,0,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,-4,2,-6,-2,4,0,2,0,-0.096757852077001,-0.134108527131783,0.0419419576191552,-0.276726342710997,-0.0235602094240837,0.821052631578947,-0.451400329489292,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.674,-0.485,"7:7","150/150","Q:T:S:D",3.19623916718558,5.52153426461584e-09,0.548179859875324,5.83063954212496,9.23910743126347,84.0861153416749,1.38810903558899,2.23953024381857e-12,11.6498430682339,8.17279939949528,98.407580019827,6.55288933297668e-17,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR779896","ERR779896","lineage4.1.1.3","pe","","pnca_p.thr76pro","A","S","THR","TA76","pnca_complex.pdb"
|
|
"T76P","L2","PZA","T","T76",76,"P",0,"MDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",14.032,-0.382,-0.519,1.15155,-1.623,-0.09,78,85,-0.548,7,7,56,0.325581395348837,"loop",-0.9,3.94,0.0017248814144027,24.4404408647732,24.4404407276145,24.4312693653994,69.8031277140286,0,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,-4,2,-6,-2,4,0,2,0,-0.096757852077001,-0.134108527131783,0.0419419576191552,-0.276726342710997,-0.0235602094240837,0.821052631578947,-0.451400329489292,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.674,-0.485,"7:7","150/150","Q:T:S:D",3.19623916718558,5.52153426461584e-09,0.548179859875324,5.83063954212496,9.23910743126347,84.0861153416749,1.38810903558899,2.23953024381857e-12,11.6498430682339,8.17279939949528,98.407580019827,6.55288933297668e-17,"lineage2","dr_mutations_pyrazinamide","PRO",0,"ERR3335751","ERR3335751","lineage2.2.1","pk","Pakistan","pnca_p.thr76pro","A","S","THR","TA76","pnca_complex.pdb"
|
|
"T76P","L2","PZA","T","T76",76,"P",1,"MDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",14.032,-0.382,-0.519,1.15155,-1.623,-0.09,78,85,-0.548,7,7,56,0.325581395348837,"loop",-0.9,3.94,0.0017248814144027,24.4404408647732,24.4404407276145,24.4312693653994,69.8031277140286,0,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,-4,2,-6,-2,4,0,2,0,-0.096757852077001,-0.134108527131783,0.0419419576191552,-0.276726342710997,-0.0235602094240837,0.821052631578947,-0.451400329489292,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.674,-0.485,"7:7","150/150","Q:T:S:D",3.19623916718558,5.52153426461584e-09,0.548179859875324,5.83063954212496,9.23910743126347,84.0861153416749,1.38810903558899,2.23953024381857e-12,11.6498430682339,8.17279939949528,98.407580019827,6.55288933297668e-17,"lineage2","dr_mutations_pyrazinamide","PRO",0,"ERR552136","ERR552136","lineage2.2.1","ru","Russia","pnca_p.thr76pro","A","S","THR","TA76","pnca_complex.pdb"
|
|
"T76P","L4","PZA","T","T76",76,"P",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",14.032,-0.382,-0.519,1.15155,-1.623,-0.09,78,85,-0.548,7,7,56,0.325581395348837,"loop",-0.9,3.94,0.0017248814144027,24.4404408647732,24.4404407276145,24.4312693653994,69.8031277140286,0,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,-4,2,-6,-2,4,0,2,0,-0.096757852077001,-0.134108527131783,0.0419419576191552,-0.276726342710997,-0.0235602094240837,0.821052631578947,-0.451400329489292,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.674,-0.485,"7:7","150/150","Q:T:S:D",3.19623916718558,5.52153426461584e-09,0.548179859875324,5.83063954212496,9.23910743126347,84.0861153416749,1.38810903558899,2.23953024381857e-12,11.6498430682339,8.17279939949528,98.407580019827,6.55288933297668e-17,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR1035364","ERR1035364","lineage4.6","br","Brazil","pnca_p.thr76pro","A","S","THR","TA76","pnca_complex.pdb"
|
|
"T76P","L2","PZA","T","T76",76,"P",NA,"XDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",14.032,-0.382,-0.519,1.15155,-1.623,-0.09,78,85,-0.548,7,7,56,0.325581395348837,"loop",-0.9,3.94,0.0017248814144027,24.4404408647732,24.4404407276145,24.4312693653994,69.8031277140286,0,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,-4,2,-6,-2,4,0,2,0,-0.096757852077001,-0.134108527131783,0.0419419576191552,-0.276726342710997,-0.0235602094240837,0.821052631578947,-0.451400329489292,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.674,-0.485,"7:7","150/150","Q:T:S:D",3.19623916718558,5.52153426461584e-09,0.548179859875324,5.83063954212496,9.23910743126347,84.0861153416749,1.38810903558899,2.23953024381857e-12,11.6498430682339,8.17279939949528,98.407580019827,6.55288933297668e-17,"lineage2","dr_mutations_pyrazinamide","PRO",0,"SAMN02419621","SRR1163414_SRR1169009_SRR1162995_SRR1174838","lineage2.2.1","by","Belarus","pnca_p.thr76pro","A","S","THR","TA76","pnca_complex.pdb"
|
|
"T76P","L4","PZA","T","T76",76,"P",NA,"MDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",14.032,-0.382,-0.519,1.15155,-1.623,-0.09,78,85,-0.548,7,7,56,0.325581395348837,"loop",-0.9,3.94,0.0017248814144027,24.4404408647732,24.4404407276145,24.4312693653994,69.8031277140286,0,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,-4,2,-6,-2,4,0,2,0,-0.096757852077001,-0.134108527131783,0.0419419576191552,-0.276726342710997,-0.0235602094240837,0.821052631578947,-0.451400329489292,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.674,-0.485,"7:7","150/150","Q:T:S:D",3.19623916718558,5.52153426461584e-09,0.548179859875324,5.83063954212496,9.23910743126347,84.0861153416749,1.38810903558899,2.23953024381857e-12,11.6498430682339,8.17279939949528,98.407580019827,6.55288933297668e-17,"lineage4","dr_mutations_pyrazinamide","PRO",0,"SRR5818577","SRR5818577","lineage4.2.2","dj","Djibouti","pnca_p.thr76pro","A","S","THR","TA76","pnca_complex.pdb"
|
|
"T76P","L4","PZA","T","T76",76,"P",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",14.032,-0.382,-0.519,1.15155,-1.623,-0.09,78,85,-0.548,7,7,56,0.325581395348837,"loop",-0.9,3.94,0.0017248814144027,24.4404408647732,24.4404407276145,24.4312693653994,69.8031277140286,0,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,-4,2,-6,-2,4,0,2,0,-0.096757852077001,-0.134108527131783,0.0419419576191552,-0.276726342710997,-0.0235602094240837,0.821052631578947,-0.451400329489292,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.674,-0.485,"7:7","150/150","Q:T:S:D",3.19623916718558,5.52153426461584e-09,0.548179859875324,5.83063954212496,9.23910743126347,84.0861153416749,1.38810903558899,2.23953024381857e-12,11.6498430682339,8.17279939949528,98.407580019827,6.55288933297668e-17,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR1035274","ERR1035274","lineage4.6","br","Brazil","pnca_p.thr76pro","A","S","THR","TA76","pnca_complex.pdb"
|
|
"T76P","L2","PZA","T","T76",76,"P",1,"MDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",14.032,-0.382,-0.519,1.15155,-1.623,-0.09,78,85,-0.548,7,7,56,0.325581395348837,"loop",-0.9,3.94,0.0017248814144027,24.4404408647732,24.4404407276145,24.4312693653994,69.8031277140286,0,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,-4,2,-6,-2,4,0,2,0,-0.096757852077001,-0.134108527131783,0.0419419576191552,-0.276726342710997,-0.0235602094240837,0.821052631578947,-0.451400329489292,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.674,-0.485,"7:7","150/150","Q:T:S:D",3.19623916718558,5.52153426461584e-09,0.548179859875324,5.83063954212496,9.23910743126347,84.0861153416749,1.38810903558899,2.23953024381857e-12,11.6498430682339,8.17279939949528,98.407580019827,6.55288933297668e-17,"lineage2","dr_mutations_pyrazinamide","PRO",0,"ERS2592749","ERR2677400","lineage2.2.1","de","Germany","pnca_p.thr76pro","A","S","THR","TA76","pnca_complex.pdb"
|
|
"T76P","L2","PZA","T","T76",76,"P",NA,"XDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",14.032,-0.382,-0.519,1.15155,-1.623,-0.09,78,85,-0.548,7,7,56,0.325581395348837,"loop",-0.9,3.94,0.0017248814144027,24.4404408647732,24.4404407276145,24.4312693653994,69.8031277140286,0,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,-4,2,-6,-2,4,0,2,0,-0.096757852077001,-0.134108527131783,0.0419419576191552,-0.276726342710997,-0.0235602094240837,0.821052631578947,-0.451400329489292,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.674,-0.485,"7:7","150/150","Q:T:S:D",3.19623916718558,5.52153426461584e-09,0.548179859875324,5.83063954212496,9.23910743126347,84.0861153416749,1.38810903558899,2.23953024381857e-12,11.6498430682339,8.17279939949528,98.407580019827,6.55288933297668e-17,"lineage2","dr_mutations_pyrazinamide","PRO",0,"SAMN02419639","SRR1163199_SRR1174829_SRR1163376_SRR1169109","lineage2.2.1","by","Belarus","pnca_p.thr76pro","A","S","THR","TA76","pnca_complex.pdb"
|
|
"T76P","L2","PZA","T","T76",76,"P",NA,"MDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",14.032,-0.382,-0.519,1.15155,-1.623,-0.09,78,85,-0.548,7,7,56,0.325581395348837,"loop",-0.9,3.94,0.0017248814144027,24.4404408647732,24.4404407276145,24.4312693653994,69.8031277140286,0,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,-4,2,-6,-2,4,0,2,0,-0.096757852077001,-0.134108527131783,0.0419419576191552,-0.276726342710997,-0.0235602094240837,0.821052631578947,-0.451400329489292,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.674,-0.485,"7:7","150/150","Q:T:S:D",3.19623916718558,5.52153426461584e-09,0.548179859875324,5.83063954212496,9.23910743126347,84.0861153416749,1.38810903558899,2.23953024381857e-12,11.6498430682339,8.17279939949528,98.407580019827,6.55288933297668e-17,"lineage2","dr_mutations_pyrazinamide","PRO",0,"BGI_140,SRR671722","SRR671722","lineage2.2.1","cn","China","pnca_p.thr76pro","A","S","THR","TA76","pnca_complex.pdb"
|
|
"T76P","L4","PZA","T","T76",76,"P",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",14.032,-0.382,-0.519,1.15155,-1.623,-0.09,78,85,-0.548,7,7,56,0.325581395348837,"loop",-0.9,3.94,0.0017248814144027,24.4404408647732,24.4404407276145,24.4312693653994,69.8031277140286,0,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,-4,2,-6,-2,4,0,2,0,-0.096757852077001,-0.134108527131783,0.0419419576191552,-0.276726342710997,-0.0235602094240837,0.821052631578947,-0.451400329489292,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.674,-0.485,"7:7","150/150","Q:T:S:D",3.19623916718558,5.52153426461584e-09,0.548179859875324,5.83063954212496,9.23910743126347,84.0861153416749,1.38810903558899,2.23953024381857e-12,11.6498430682339,8.17279939949528,98.407580019827,6.55288933297668e-17,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR1035303","ERR1035303","lineage4.6","br","Brazil","pnca_p.thr76pro","A","S","THR","TA76","pnca_complex.pdb"
|
|
"T76P","L4","PZA","T","T76",76,"P",NA,"MDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",14.032,-0.382,-0.519,1.15155,-1.623,-0.09,78,85,-0.548,7,7,56,0.325581395348837,"loop",-0.9,3.94,0.0017248814144027,24.4404408647732,24.4404407276145,24.4312693653994,69.8031277140286,0,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,-4,2,-6,-2,4,0,2,0,-0.096757852077001,-0.134108527131783,0.0419419576191552,-0.276726342710997,-0.0235602094240837,0.821052631578947,-0.451400329489292,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.674,-0.485,"7:7","150/150","Q:T:S:D",3.19623916718558,5.52153426461584e-09,0.548179859875324,5.83063954212496,9.23910743126347,84.0861153416749,1.38810903558899,2.23953024381857e-12,11.6498430682339,8.17279939949528,98.407580019827,6.55288933297668e-17,"lineage4","dr_mutations_pyrazinamide","PRO",0,"SAMN02403583","SRR1172095_SRR1169184_SRR1167378_SRR1165625","lineage4.3.3","za","South Africa","pnca_p.thr76pro","A","S","THR","TA76","pnca_complex.pdb"
|
|
"T76P","L2","PZA","T","T76",76,"P",1,"Pre-XDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",14.032,-0.382,-0.519,1.15155,-1.623,-0.09,78,85,-0.548,7,7,56,0.325581395348837,"loop",-0.9,3.94,0.0017248814144027,24.4404408647732,24.4404407276145,24.4312693653994,69.8031277140286,0,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,-4,2,-6,-2,4,0,2,0,-0.096757852077001,-0.134108527131783,0.0419419576191552,-0.276726342710997,-0.0235602094240837,0.821052631578947,-0.451400329489292,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.674,-0.485,"7:7","150/150","Q:T:S:D",3.19623916718558,5.52153426461584e-09,0.548179859875324,5.83063954212496,9.23910743126347,84.0861153416749,1.38810903558899,2.23953024381857e-12,11.6498430682339,8.17279939949528,98.407580019827,6.55288933297668e-17,"lineage2","dr_mutations_pyrazinamide","PRO",0,"ERS2592762","ERR2677414","lineage2.2.1","de","Germany","pnca_p.thr76pro","A","S","THR","TA76","pnca_complex.pdb"
|
|
"T76P","L2","PZA","T","T76",76,"P",0,"Pre-XDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",14.032,-0.382,-0.519,1.15155,-1.623,-0.09,78,85,-0.548,7,7,56,0.325581395348837,"loop",-0.9,3.94,0.0017248814144027,24.4404408647732,24.4404407276145,24.4312693653994,69.8031277140286,0,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,-4,2,-6,-2,4,0,2,0,-0.096757852077001,-0.134108527131783,0.0419419576191552,-0.276726342710997,-0.0235602094240837,0.821052631578947,-0.451400329489292,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.674,-0.485,"7:7","150/150","Q:T:S:D",3.19623916718558,5.52153426461584e-09,0.548179859875324,5.83063954212496,9.23910743126347,84.0861153416749,1.38810903558899,2.23953024381857e-12,11.6498430682339,8.17279939949528,98.407580019827,6.55288933297668e-17,"lineage2","dr_mutations_pyrazinamide","PRO",0,"ERS458098","ERR552510_ERR552509","lineage2.2.1","uz","Nukus","pnca_p.thr76pro","A","S","THR","TA76","pnca_complex.pdb"
|
|
"T76P","L3","PZA","T","T76",76,"P",1,"MDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",14.032,-0.382,-0.519,1.15155,-1.623,-0.09,78,85,-0.548,7,7,56,0.325581395348837,"loop",-0.9,3.94,0.0017248814144027,24.4404408647732,24.4404407276145,24.4312693653994,69.8031277140286,0,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,-4,2,-6,-2,4,0,2,0,-0.096757852077001,-0.134108527131783,0.0419419576191552,-0.276726342710997,-0.0235602094240837,0.821052631578947,-0.451400329489292,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.674,-0.485,"7:7","150/150","Q:T:S:D",3.19623916718558,5.52153426461584e-09,0.548179859875324,5.83063954212496,9.23910743126347,84.0861153416749,1.38810903558899,2.23953024381857e-12,11.6498430682339,8.17279939949528,98.407580019827,6.55288933297668e-17,"lineage3","dr_mutations_pyrazinamide","PRO",0,"ERR2510624","ERR2510624","lineage3","pk","Pakistan","pnca_p.thr76pro","A","S","THR","TA76","pnca_complex.pdb"
|
|
"T76P","L4","PZA","T","T76",76,"P",NA,"MDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",14.032,-0.382,-0.519,1.15155,-1.623,-0.09,78,85,-0.548,7,7,56,0.325581395348837,"loop",-0.9,3.94,0.0017248814144027,24.4404408647732,24.4404407276145,24.4312693653994,69.8031277140286,0,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,-4,2,-6,-2,4,0,2,0,-0.096757852077001,-0.134108527131783,0.0419419576191552,-0.276726342710997,-0.0235602094240837,0.821052631578947,-0.451400329489292,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.674,-0.485,"7:7","150/150","Q:T:S:D",3.19623916718558,5.52153426461584e-09,0.548179859875324,5.83063954212496,9.23910743126347,84.0861153416749,1.38810903558899,2.23953024381857e-12,11.6498430682339,8.17279939949528,98.407580019827,6.55288933297668e-17,"lineage4","dr_mutations_pyrazinamide","PRO",0,"SAMN02584606","SRR1168962_SRR1166193","lineage4.3.3","md","Moldova","pnca_p.thr76pro","A","S","THR","TA76","pnca_complex.pdb"
|
|
"T76P","L4","PZA","T","T76",76,"P",1,"Pre-XDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",14.032,-0.382,-0.519,1.15155,-1.623,-0.09,78,85,-0.548,7,7,56,0.325581395348837,"loop",-0.9,3.94,0.0017248814144027,24.4404408647732,24.4404407276145,24.4312693653994,69.8031277140286,0,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,-4,2,-6,-2,4,0,2,0,-0.096757852077001,-0.134108527131783,0.0419419576191552,-0.276726342710997,-0.0235602094240837,0.821052631578947,-0.451400329489292,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.674,-0.485,"7:7","150/150","Q:T:S:D",3.19623916718558,5.52153426461584e-09,0.548179859875324,5.83063954212496,9.23910743126347,84.0861153416749,1.38810903558899,2.23953024381857e-12,11.6498430682339,8.17279939949528,98.407580019827,6.55288933297668e-17,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERS2592764","ERR2677416","lineage4.3.3","de","Germany","pnca_p.thr76pro","A","S","THR","TA76","pnca_complex.pdb"
|
|
"T76P","L4","PZA","T","T76",76,"P",NA,"MDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",14.032,-0.382,-0.519,1.15155,-1.623,-0.09,78,85,-0.548,7,7,56,0.325581395348837,"loop",-0.9,3.94,0.0017248814144027,24.4404408647732,24.4404407276145,24.4312693653994,69.8031277140286,0,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,-4,2,-6,-2,4,0,2,0,-0.096757852077001,-0.134108527131783,0.0419419576191552,-0.276726342710997,-0.0235602094240837,0.821052631578947,-0.451400329489292,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.674,-0.485,"7:7","150/150","Q:T:S:D",3.19623916718558,5.52153426461584e-09,0.548179859875324,5.83063954212496,9.23910743126347,84.0861153416749,1.38810903558899,2.23953024381857e-12,11.6498430682339,8.17279939949528,98.407580019827,6.55288933297668e-17,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR2707174","ERR2707174","lineage4.6.1.2","cd","Democratic Republic of Congo","pnca_p.thr76pro","A","S","THR","TA76","pnca_complex.pdb"
|
|
"T76P","L1","PZA","T","T76",76,"P",1,"MDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",14.032,-0.382,-0.519,1.15155,-1.623,-0.09,78,85,-0.548,7,7,56,0.325581395348837,"loop",-0.9,3.94,0.0017248814144027,24.4404408647732,24.4404407276145,24.4312693653994,69.8031277140286,0,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,-4,2,-6,-2,4,0,2,0,-0.096757852077001,-0.134108527131783,0.0419419576191552,-0.276726342710997,-0.0235602094240837,0.821052631578947,-0.451400329489292,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.674,-0.485,"7:7","150/150","Q:T:S:D",3.19623916718558,5.52153426461584e-09,0.548179859875324,5.83063954212496,9.23910743126347,84.0861153416749,1.38810903558899,2.23953024381857e-12,11.6498430682339,8.17279939949528,98.407580019827,6.55288933297668e-17,"lineage1","dr_mutations_pyrazinamide","PRO",0,"SRR5817479","SRR5817479","lineage1.2.1","au","Australia","pnca_p.thr76pro","A","S","THR","TA76","pnca_complex.pdb"
|
|
"T76P","L4","PZA","T","T76",76,"P",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",14.032,-0.382,-0.519,1.15155,-1.623,-0.09,78,85,-0.548,7,7,56,0.325581395348837,"loop",-0.9,3.94,0.0017248814144027,24.4404408647732,24.4404407276145,24.4312693653994,69.8031277140286,0,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,-4,2,-6,-2,4,0,2,0,-0.096757852077001,-0.134108527131783,0.0419419576191552,-0.276726342710997,-0.0235602094240837,0.821052631578947,-0.451400329489292,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.674,-0.485,"7:7","150/150","Q:T:S:D",3.19623916718558,5.52153426461584e-09,0.548179859875324,5.83063954212496,9.23910743126347,84.0861153416749,1.38810903558899,2.23953024381857e-12,11.6498430682339,8.17279939949528,98.407580019827,6.55288933297668e-17,"lineage4","dr_mutations_pyrazinamide","PRO",0,"SAMN02567704","SRR1166178","lineage4.9","ro","Romania","pnca_p.thr76pro","A","S","THR","TA76","pnca_complex.pdb"
|
|
"T76P","L3","PZA","T","T76",76,"P",1,"MDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",14.032,-0.382,-0.519,1.15155,-1.623,-0.09,78,85,-0.548,7,7,56,0.325581395348837,"loop",-0.9,3.94,0.0017248814144027,24.4404408647732,24.4404407276145,24.4312693653994,69.8031277140286,0,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,-4,2,-6,-2,4,0,2,0,-0.096757852077001,-0.134108527131783,0.0419419576191552,-0.276726342710997,-0.0235602094240837,0.821052631578947,-0.451400329489292,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.674,-0.485,"7:7","150/150","Q:T:S:D",3.19623916718558,5.52153426461584e-09,0.548179859875324,5.83063954212496,9.23910743126347,84.0861153416749,1.38810903558899,2.23953024381857e-12,11.6498430682339,8.17279939949528,98.407580019827,6.55288933297668e-17,"lineage3","dr_mutations_pyrazinamide","PRO",0,"ERR550764,SAMEA2533452","ERR550764","lineage3.1.1","","","pnca_p.thr76pro","A","S","THR","TA76","pnca_complex.pdb"
|
|
"T76P","L4","PZA","T","T76",76,"P",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",14.032,-0.382,-0.519,1.15155,-1.623,-0.09,78,85,-0.548,7,7,56,0.325581395348837,"loop",-0.9,3.94,0.0017248814144027,24.4404408647732,24.4404407276145,24.4312693653994,69.8031277140286,0,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,-4,2,-6,-2,4,0,2,0,-0.096757852077001,-0.134108527131783,0.0419419576191552,-0.276726342710997,-0.0235602094240837,0.821052631578947,-0.451400329489292,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.674,-0.485,"7:7","150/150","Q:T:S:D",3.19623916718558,5.52153426461584e-09,0.548179859875324,5.83063954212496,9.23910743126347,84.0861153416749,1.38810903558899,2.23953024381857e-12,11.6498430682339,8.17279939949528,98.407580019827,6.55288933297668e-17,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR1035259","ERR1035259","lineage4.6","br","Brazil","pnca_p.thr76pro","A","S","THR","TA76","pnca_complex.pdb"
|
|
"T76P","L4","PZA","T","T76",76,"P",NA,"XDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",14.032,-0.382,-0.519,1.15155,-1.623,-0.09,78,85,-0.548,7,7,56,0.325581395348837,"loop",-0.9,3.94,0.0017248814144027,24.4404408647732,24.4404407276145,24.4312693653994,69.8031277140286,0,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,-4,2,-6,-2,4,0,2,0,-0.096757852077001,-0.134108527131783,0.0419419576191552,-0.276726342710997,-0.0235602094240837,0.821052631578947,-0.451400329489292,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.674,-0.485,"7:7","150/150","Q:T:S:D",3.19623916718558,5.52153426461584e-09,0.548179859875324,5.83063954212496,9.23910743126347,84.0861153416749,1.38810903558899,2.23953024381857e-12,11.6498430682339,8.17279939949528,98.407580019827,6.55288933297668e-17,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR1034809","ERR1034809","lineage4.8","pt","Portugal","pnca_p.thr76pro","A","S","THR","TA76","pnca_complex.pdb"
|
|
"T76P","L4","PZA","T","T76",76,"P",NA,"MDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",14.032,-0.382,-0.519,1.15155,-1.623,-0.09,78,85,-0.548,7,7,56,0.325581395348837,"loop",-0.9,3.94,0.0017248814144027,24.4404408647732,24.4404407276145,24.4312693653994,69.8031277140286,0,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,-4,2,-6,-2,4,0,2,0,-0.096757852077001,-0.134108527131783,0.0419419576191552,-0.276726342710997,-0.0235602094240837,0.821052631578947,-0.451400329489292,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.674,-0.485,"7:7","150/150","Q:T:S:D",3.19623916718558,5.52153426461584e-09,0.548179859875324,5.83063954212496,9.23910743126347,84.0861153416749,1.38810903558899,2.23953024381857e-12,11.6498430682339,8.17279939949528,98.407580019827,6.55288933297668e-17,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR1035319","ERR1035319","lineage4.6","br","Brazil","pnca_p.thr76pro","A","S","THR","TA76","pnca_complex.pdb"
|
|
"T76P","L3","PZA","T","T76",76,"P",1,"MDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",14.032,-0.382,-0.519,1.15155,-1.623,-0.09,78,85,-0.548,7,7,56,0.325581395348837,"loop",-0.9,3.94,0.0017248814144027,24.4404408647732,24.4404407276145,24.4312693653994,69.8031277140286,0,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,-4,2,-6,-2,4,0,2,0,-0.096757852077001,-0.134108527131783,0.0419419576191552,-0.276726342710997,-0.0235602094240837,0.821052631578947,-0.451400329489292,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.674,-0.485,"7:7","150/150","Q:T:S:D",3.19623916718558,5.52153426461584e-09,0.548179859875324,5.83063954212496,9.23910743126347,84.0861153416749,1.38810903558899,2.23953024381857e-12,11.6498430682339,8.17279939949528,98.407580019827,6.55288933297668e-17,"lineage3","dr_mutations_pyrazinamide","PRO",0,"ERR2510289","ERR2510289","lineage3","pk","Pakistan","pnca_p.thr76pro","A","S","THR","TA76","pnca_complex.pdb"
|
|
"T76P","L2","PZA","T","T76",76,"P",NA,"XDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",14.032,-0.382,-0.519,1.15155,-1.623,-0.09,78,85,-0.548,7,7,56,0.325581395348837,"loop",-0.9,3.94,0.0017248814144027,24.4404408647732,24.4404407276145,24.4312693653994,69.8031277140286,0,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,-4,2,-6,-2,4,0,2,0,-0.096757852077001,-0.134108527131783,0.0419419576191552,-0.276726342710997,-0.0235602094240837,0.821052631578947,-0.451400329489292,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.674,-0.485,"7:7","150/150","Q:T:S:D",3.19623916718558,5.52153426461584e-09,0.548179859875324,5.83063954212496,9.23910743126347,84.0861153416749,1.38810903558899,2.23953024381857e-12,11.6498430682339,8.17279939949528,98.407580019827,6.55288933297668e-17,"lineage2","dr_mutations_pyrazinamide","PRO",0,"SRS796946","SRR1723431","lineage2.2.2","cn","China:Hebei","pnca_p.thr76pro","A","S","THR","TA76","pnca_complex.pdb"
|
|
"T76P","L2","PZA","T","T76",76,"P",NA,"XDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",14.032,-0.382,-0.519,1.15155,-1.623,-0.09,78,85,-0.548,7,7,56,0.325581395348837,"loop",-0.9,3.94,0.0017248814144027,24.4404408647732,24.4404407276145,24.4312693653994,69.8031277140286,0,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,-4,2,-6,-2,4,0,2,0,-0.096757852077001,-0.134108527131783,0.0419419576191552,-0.276726342710997,-0.0235602094240837,0.821052631578947,-0.451400329489292,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.674,-0.485,"7:7","150/150","Q:T:S:D",3.19623916718558,5.52153426461584e-09,0.548179859875324,5.83063954212496,9.23910743126347,84.0861153416749,1.38810903558899,2.23953024381857e-12,11.6498430682339,8.17279939949528,98.407580019827,6.55288933297668e-17,"lineage2","dr_mutations_pyrazinamide","PRO",0,"SAMN02360595","SRR1049026_SRR1013629_SRR1049027_SRR1013630","lineage2.2.2","kr","South Korea","pnca_p.thr76pro","A","S","THR","TA76","pnca_complex.pdb"
|
|
"T76P","L2","PZA","T","T76",76,"P",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",14.032,-0.382,-0.519,1.15155,-1.623,-0.09,78,85,-0.548,7,7,56,0.325581395348837,"loop",-0.9,3.94,0.0017248814144027,24.4404408647732,24.4404407276145,24.4312693653994,69.8031277140286,0,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,-4,2,-6,-2,4,0,2,0,-0.096757852077001,-0.134108527131783,0.0419419576191552,-0.276726342710997,-0.0235602094240837,0.821052631578947,-0.451400329489292,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.674,-0.485,"7:7","150/150","Q:T:S:D",3.19623916718558,5.52153426461584e-09,0.548179859875324,5.83063954212496,9.23910743126347,84.0861153416749,1.38810903558899,2.23953024381857e-12,11.6498430682339,8.17279939949528,98.407580019827,6.55288933297668e-17,"lineage2","dr_mutations_pyrazinamide","PRO",0,"SAMN07236252,SRR5709949","SRR5709949","lineage2.2.1","th","Thailand","pnca_p.thr76pro","A","S","THR","TA76","pnca_complex.pdb"
|
|
"T76P","L4","PZA","T","T76",76,"P",NA,"MDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",14.032,-0.382,-0.519,1.15155,-1.623,-0.09,78,85,-0.548,7,7,56,0.325581395348837,"loop",-0.9,3.94,0.0017248814144027,24.4404408647732,24.4404407276145,24.4312693653994,69.8031277140286,0,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,-4,2,-6,-2,4,0,2,0,-0.096757852077001,-0.134108527131783,0.0419419576191552,-0.276726342710997,-0.0235602094240837,0.821052631578947,-0.451400329489292,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.674,-0.485,"7:7","150/150","Q:T:S:D",3.19623916718558,5.52153426461584e-09,0.548179859875324,5.83063954212496,9.23910743126347,84.0861153416749,1.38810903558899,2.23953024381857e-12,11.6498430682339,8.17279939949528,98.407580019827,6.55288933297668e-17,"lineage4","dr_mutations_pyrazinamide","PRO",0,"SAMN02403481","SRR1165332_SRR1173851_SRR1173860_SRR1167321","lineage4.3.2","za","South Africa","pnca_p.thr76pro","A","S","THR","TA76","pnca_complex.pdb"
|
|
"T76P","L4","PZA","T","T76",76,"P",NA,"MDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",14.032,-0.382,-0.519,1.15155,-1.623,-0.09,78,85,-0.548,7,7,56,0.325581395348837,"loop",-0.9,3.94,0.0017248814144027,24.4404408647732,24.4404407276145,24.4312693653994,69.8031277140286,0,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,-4,2,-6,-2,4,0,2,0,-0.096757852077001,-0.134108527131783,0.0419419576191552,-0.276726342710997,-0.0235602094240837,0.821052631578947,-0.451400329489292,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.674,-0.485,"7:7","150/150","Q:T:S:D",3.19623916718558,5.52153426461584e-09,0.548179859875324,5.83063954212496,9.23910743126347,84.0861153416749,1.38810903558899,2.23953024381857e-12,11.6498430682339,8.17279939949528,98.407580019827,6.55288933297668e-17,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR1035307","ERR1035307","lineage4.6","br","Brazil","pnca_p.thr76pro","A","S","THR","TA76","pnca_complex.pdb"
|
|
"T76P","L4","PZA","T","T76",76,"P",NA,"XDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",14.032,-0.382,-0.519,1.15155,-1.623,-0.09,78,85,-0.548,7,7,56,0.325581395348837,"loop",-0.9,3.94,0.0017248814144027,24.4404408647732,24.4404407276145,24.4312693653994,69.8031277140286,0,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,-4,2,-6,-2,4,0,2,0,-0.096757852077001,-0.134108527131783,0.0419419576191552,-0.276726342710997,-0.0235602094240837,0.821052631578947,-0.451400329489292,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.674,-0.485,"7:7","150/150","Q:T:S:D",3.19623916718558,5.52153426461584e-09,0.548179859875324,5.83063954212496,9.23910743126347,84.0861153416749,1.38810903558899,2.23953024381857e-12,11.6498430682339,8.17279939949528,98.407580019827,6.55288933297668e-17,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR1035348","ERR1035348","lineage4.6","br","Brazil","pnca_p.thr76pro","A","S","THR","TA76","pnca_complex.pdb"
|
|
"T76P","L2","PZA","T","T76",76,"P",0,"Pre-XDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",14.032,-0.382,-0.519,1.15155,-1.623,-0.09,78,85,-0.548,7,7,56,0.325581395348837,"loop",-0.9,3.94,0.0017248814144027,24.4404408647732,24.4404407276145,24.4312693653994,69.8031277140286,0,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,-4,2,-6,-2,4,0,2,0,-0.096757852077001,-0.134108527131783,0.0419419576191552,-0.276726342710997,-0.0235602094240837,0.821052631578947,-0.451400329489292,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.674,-0.485,"7:7","150/150","Q:T:S:D",3.19623916718558,5.52153426461584e-09,0.548179859875324,5.83063954212496,9.23910743126347,84.0861153416749,1.38810903558899,2.23953024381857e-12,11.6498430682339,8.17279939949528,98.407580019827,6.55288933297668e-17,"lineage2","dr_mutations_pyrazinamide","PRO",0,"SAMEA2534634,ERS458036","ERR552417_ERR552418","lineage2.2.1","uz","Nukus","pnca_p.thr76pro","A","S","THR","TA76","pnca_complex.pdb"
|
|
"T76P","L4","PZA","T","T76",76,"P",NA,"XDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",14.032,-0.382,-0.519,1.15155,-1.623,-0.09,78,85,-0.548,7,7,56,0.325581395348837,"loop",-0.9,3.94,0.0017248814144027,24.4404408647732,24.4404407276145,24.4312693653994,69.8031277140286,0,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,-4,2,-6,-2,4,0,2,0,-0.096757852077001,-0.134108527131783,0.0419419576191552,-0.276726342710997,-0.0235602094240837,0.821052631578947,-0.451400329489292,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.674,-0.485,"7:7","150/150","Q:T:S:D",3.19623916718558,5.52153426461584e-09,0.548179859875324,5.83063954212496,9.23910743126347,84.0861153416749,1.38810903558899,2.23953024381857e-12,11.6498430682339,8.17279939949528,98.407580019827,6.55288933297668e-17,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR1035355","ERR1035355","lineage4.6","br","Brazil","pnca_p.thr76pro","A","S","THR","TA76","pnca_complex.pdb"
|
|
"T76P","L4","PZA","T","T76",76,"P",NA,"XDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",14.032,-0.382,-0.519,1.15155,-1.623,-0.09,78,85,-0.548,7,7,56,0.325581395348837,"loop",-0.9,3.94,0.0017248814144027,24.4404408647732,24.4404407276145,24.4312693653994,69.8031277140286,0,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,-4,2,-6,-2,4,0,2,0,-0.096757852077001,-0.134108527131783,0.0419419576191552,-0.276726342710997,-0.0235602094240837,0.821052631578947,-0.451400329489292,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.674,-0.485,"7:7","150/150","Q:T:S:D",3.19623916718558,5.52153426461584e-09,0.548179859875324,5.83063954212496,9.23910743126347,84.0861153416749,1.38810903558899,2.23953024381857e-12,11.6498430682339,8.17279939949528,98.407580019827,6.55288933297668e-17,"lineage4","dr_mutations_pyrazinamide","PRO",0,"SAMN02567732","SRR1166189","lineage4.1.2.1","ro","Romania","pnca_p.thr76pro","A","S","THR","TA76","pnca_complex.pdb"
|
|
"T76P","L2","PZA","T","T76",76,"P",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",14.032,-0.382,-0.519,1.15155,-1.623,-0.09,78,85,-0.548,7,7,56,0.325581395348837,"loop",-0.9,3.94,0.0017248814144027,24.4404408647732,24.4404407276145,24.4312693653994,69.8031277140286,0,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,-4,2,-6,-2,4,0,2,0,-0.096757852077001,-0.134108527131783,0.0419419576191552,-0.276726342710997,-0.0235602094240837,0.821052631578947,-0.451400329489292,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.674,-0.485,"7:7","150/150","Q:T:S:D",3.19623916718558,5.52153426461584e-09,0.548179859875324,5.83063954212496,9.23910743126347,84.0861153416749,1.38810903558899,2.23953024381857e-12,11.6498430682339,8.17279939949528,98.407580019827,6.55288933297668e-17,"lineage2","dr_mutations_pyrazinamide","PRO",0,"SAMN02414967","SRR1165604_SRR1166869_SRR1165502_SRR1162811","lineage2.2.1","se","Sweden","pnca_p.thr76pro","A","S","THR","TA76","pnca_complex.pdb"
|
|
"T76P","L4","PZA","T","T76",76,"P",NA,"MDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",14.032,-0.382,-0.519,1.15155,-1.623,-0.09,78,85,-0.548,7,7,56,0.325581395348837,"loop",-0.9,3.94,0.0017248814144027,24.4404408647732,24.4404407276145,24.4312693653994,69.8031277140286,0,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,-4,2,-6,-2,4,0,2,0,-0.096757852077001,-0.134108527131783,0.0419419576191552,-0.276726342710997,-0.0235602094240837,0.821052631578947,-0.451400329489292,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.674,-0.485,"7:7","150/150","Q:T:S:D",3.19623916718558,5.52153426461584e-09,0.548179859875324,5.83063954212496,9.23910743126347,84.0861153416749,1.38810903558899,2.23953024381857e-12,11.6498430682339,8.17279939949528,98.407580019827,6.55288933297668e-17,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR718464","ERR718464","lineage4.4.2","th","Thailand","pnca_p.thr76pro","A","S","THR","TA76","pnca_complex.pdb"
|
|
"T76P","L4","PZA","T","T76",76,"P",1,"Pre-XDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",14.032,-0.382,-0.519,1.15155,-1.623,-0.09,78,85,-0.548,7,7,56,0.325581395348837,"loop",-0.9,3.94,0.0017248814144027,24.4404408647732,24.4404407276145,24.4312693653994,69.8031277140286,0,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,-4,2,-6,-2,4,0,2,0,-0.096757852077001,-0.134108527131783,0.0419419576191552,-0.276726342710997,-0.0235602094240837,0.821052631578947,-0.451400329489292,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.674,-0.485,"7:7","150/150","Q:T:S:D",3.19623916718558,5.52153426461584e-09,0.548179859875324,5.83063954212496,9.23910743126347,84.0861153416749,1.38810903558899,2.23953024381857e-12,11.6498430682339,8.17279939949528,98.407580019827,6.55288933297668e-17,"lineage4","dr_mutations_pyrazinamide","PRO",0,"SAMN10961330","SRR8651660","lineage4.4.2","cn","China:Wenzhou","pnca_p.thr76pro","A","S","THR","TA76","pnca_complex.pdb"
|
|
"T76P","L4","PZA","T","T76",76,"P",NA,"MDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",14.032,-0.382,-0.519,1.15155,-1.623,-0.09,78,85,-0.548,7,7,56,0.325581395348837,"loop",-0.9,3.94,0.0017248814144027,24.4404408647732,24.4404407276145,24.4312693653994,69.8031277140286,0,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,-4,2,-6,-2,4,0,2,0,-0.096757852077001,-0.134108527131783,0.0419419576191552,-0.276726342710997,-0.0235602094240837,0.821052631578947,-0.451400329489292,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.674,-0.485,"7:7","150/150","Q:T:S:D",3.19623916718558,5.52153426461584e-09,0.548179859875324,5.83063954212496,9.23910743126347,84.0861153416749,1.38810903558899,2.23953024381857e-12,11.6498430682339,8.17279939949528,98.407580019827,6.55288933297668e-17,"lineage4","dr_mutations_pyrazinamide","PRO",0,"SAMN02403480","SRR1165278_SRR1175350_SRR1167261_SRR1173155","lineage4.3.2","za","South Africa","pnca_p.thr76pro","A","S","THR","TA76","pnca_complex.pdb"
|
|
"T76P","L2","PZA","T","T76",76,"P",1,"MDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",14.032,-0.382,-0.519,1.15155,-1.623,-0.09,78,85,-0.548,7,7,56,0.325581395348837,"loop",-0.9,3.94,0.0017248814144027,24.4404408647732,24.4404407276145,24.4312693653994,69.8031277140286,0,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,-4,2,-6,-2,4,0,2,0,-0.096757852077001,-0.134108527131783,0.0419419576191552,-0.276726342710997,-0.0235602094240837,0.821052631578947,-0.451400329489292,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.674,-0.485,"7:7","150/150","Q:T:S:D",3.19623916718558,5.52153426461584e-09,0.548179859875324,5.83063954212496,9.23910743126347,84.0861153416749,1.38810903558899,2.23953024381857e-12,11.6498430682339,8.17279939949528,98.407580019827,6.55288933297668e-17,"lineage2","dr_mutations_pyrazinamide","PRO",0,"SAMN10961327","SRR8651659","lineage2.2.1","cn","China:Wenzhou","pnca_p.thr76pro","A","S","THR","TA76","pnca_complex.pdb"
|
|
"T76P","L2","PZA","T","T76",76,"P",1,"XDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",14.032,-0.382,-0.519,1.15155,-1.623,-0.09,78,85,-0.548,7,7,56,0.325581395348837,"loop",-0.9,3.94,0.0017248814144027,24.4404408647732,24.4404407276145,24.4312693653994,69.8031277140286,0,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,-4,2,-6,-2,4,0,2,0,-0.096757852077001,-0.134108527131783,0.0419419576191552,-0.276726342710997,-0.0235602094240837,0.821052631578947,-0.451400329489292,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.674,-0.485,"7:7","150/150","Q:T:S:D",3.19623916718558,5.52153426461584e-09,0.548179859875324,5.83063954212496,9.23910743126347,84.0861153416749,1.38810903558899,2.23953024381857e-12,11.6498430682339,8.17279939949528,98.407580019827,6.55288933297668e-17,"lineage2","dr_mutations_pyrazinamide","PRO",0,"MDR_3349","SRR6824613","lineage2.2.2","cn","China: Zhangbei County, Zhangjiakou City, Hebei Province","pnca_p.thr76pro","A","S","THR","TA76","pnca_complex.pdb"
|
|
"T76P","L2","PZA","T","T76",76,"P",NA,"Pre-MDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",14.032,-0.382,-0.519,1.15155,-1.623,-0.09,78,85,-0.548,7,7,56,0.325581395348837,"loop",-0.9,3.94,0.0017248814144027,24.4404408647732,24.4404407276145,24.4312693653994,69.8031277140286,0,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,-4,2,-6,-2,4,0,2,0,-0.096757852077001,-0.134108527131783,0.0419419576191552,-0.276726342710997,-0.0235602094240837,0.821052631578947,-0.451400329489292,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.674,-0.485,"7:7","150/150","Q:T:S:D",3.19623916718558,5.52153426461584e-09,0.548179859875324,5.83063954212496,9.23910743126347,84.0861153416749,1.38810903558899,2.23953024381857e-12,11.6498430682339,8.17279939949528,98.407580019827,6.55288933297668e-17,"lineage2","dr_mutations_pyrazinamide","PRO",0,"SRS797244","SRR1723769","lineage2.2.1","cn","China:Hebei","pnca_p.thr76pro","A","S","THR","TA76","pnca_complex.pdb"
|
|
"T76P","L4","PZA","T","T76",76,"P",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",14.032,-0.382,-0.519,1.15155,-1.623,-0.09,78,85,-0.548,7,7,56,0.325581395348837,"loop",-0.9,3.94,0.0017248814144027,24.4404408647732,24.4404407276145,24.4312693653994,69.8031277140286,0,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,-4,2,-6,-2,4,0,2,0,-0.096757852077001,-0.134108527131783,0.0419419576191552,-0.276726342710997,-0.0235602094240837,0.821052631578947,-0.451400329489292,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.674,-0.485,"7:7","150/150","Q:T:S:D",3.19623916718558,5.52153426461584e-09,0.548179859875324,5.83063954212496,9.23910743126347,84.0861153416749,1.38810903558899,2.23953024381857e-12,11.6498430682339,8.17279939949528,98.407580019827,6.55288933297668e-17,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR1035325","ERR1035325","lineage4.6","br","Brazil","pnca_p.thr76pro","A","S","THR","TA76","pnca_complex.pdb"
|
|
"T76P","L2","PZA","T","T76",76,"P",NA,"Pre-MDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",14.032,-0.382,-0.519,1.15155,-1.623,-0.09,78,85,-0.548,7,7,56,0.325581395348837,"loop",-0.9,3.94,0.0017248814144027,24.4404408647732,24.4404407276145,24.4312693653994,69.8031277140286,0,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,-4,2,-6,-2,4,0,2,0,-0.096757852077001,-0.134108527131783,0.0419419576191552,-0.276726342710997,-0.0235602094240837,0.821052631578947,-0.451400329489292,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.674,-0.485,"7:7","150/150","Q:T:S:D",3.19623916718558,5.52153426461584e-09,0.548179859875324,5.83063954212496,9.23910743126347,84.0861153416749,1.38810903558899,2.23953024381857e-12,11.6498430682339,8.17279939949528,98.407580019827,6.55288933297668e-17,"lineage2","dr_mutations_pyrazinamide","PRO",0,"SAMN02628507","SRR1173687","lineage2.2.1","ir","Iran","pnca_p.thr76pro","A","S","THR","TA76","pnca_complex.pdb"
|
|
"T76P","L2","PZA","T","T76",76,"P",NA,"MDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",14.032,-0.382,-0.519,1.15155,-1.623,-0.09,78,85,-0.548,7,7,56,0.325581395348837,"loop",-0.9,3.94,0.0017248814144027,24.4404408647732,24.4404407276145,24.4312693653994,69.8031277140286,0,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,-4,2,-6,-2,4,0,2,0,-0.096757852077001,-0.134108527131783,0.0419419576191552,-0.276726342710997,-0.0235602094240837,0.821052631578947,-0.451400329489292,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.674,-0.485,"7:7","150/150","Q:T:S:D",3.19623916718558,5.52153426461584e-09,0.548179859875324,5.83063954212496,9.23910743126347,84.0861153416749,1.38810903558899,2.23953024381857e-12,11.6498430682339,8.17279939949528,98.407580019827,6.55288933297668e-17,"lineage2","dr_mutations_pyrazinamide","PRO",0,"SRR5074185","SRR5074185","lineage2.2.1","vn","Vietnam","pnca_p.thr76pro","A","S","THR","TA76","pnca_complex.pdb"
|
|
"T76P","L4","PZA","T","T76",76,"P",NA,"MDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",14.032,-0.382,-0.519,1.15155,-1.623,-0.09,78,85,-0.548,7,7,56,0.325581395348837,"loop",-0.9,3.94,0.0017248814144027,24.4404408647732,24.4404407276145,24.4312693653994,69.8031277140286,0,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,-4,2,-6,-2,4,0,2,0,-0.096757852077001,-0.134108527131783,0.0419419576191552,-0.276726342710997,-0.0235602094240837,0.821052631578947,-0.451400329489292,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.674,-0.485,"7:7","150/150","Q:T:S:D",3.19623916718558,5.52153426461584e-09,0.548179859875324,5.83063954212496,9.23910743126347,84.0861153416749,1.38810903558899,2.23953024381857e-12,11.6498430682339,8.17279939949528,98.407580019827,6.55288933297668e-17,"lineage4","dr_mutations_pyrazinamide","PRO",0,"SRR7517789","SRR7517789","lineage4.1","ci","Ivory_Coast","pnca_p.thr76pro","A","S","THR","TA76","pnca_complex.pdb"
|
|
"T76P","L4","PZA","T","T76",76,"P",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",14.032,-0.382,-0.519,1.15155,-1.623,-0.09,78,85,-0.548,7,7,56,0.325581395348837,"loop",-0.9,3.94,0.0017248814144027,24.4404408647732,24.4404407276145,24.4312693653994,69.8031277140286,0,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,-4,2,-6,-2,4,0,2,0,-0.096757852077001,-0.134108527131783,0.0419419576191552,-0.276726342710997,-0.0235602094240837,0.821052631578947,-0.451400329489292,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.674,-0.485,"7:7","150/150","Q:T:S:D",3.19623916718558,5.52153426461584e-09,0.548179859875324,5.83063954212496,9.23910743126347,84.0861153416749,1.38810903558899,2.23953024381857e-12,11.6498430682339,8.17279939949528,98.407580019827,6.55288933297668e-17,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR1034810","ERR1034810","lineage4.8","pt","Portugal","pnca_p.thr76pro","A","S","THR","TA76","pnca_complex.pdb"
|
|
"T76P","L4","PZA","T","T76",76,"P",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",14.032,-0.382,-0.519,1.15155,-1.623,-0.09,78,85,-0.548,7,7,56,0.325581395348837,"loop",-0.9,3.94,0.0017248814144027,24.4404408647732,24.4404407276145,24.4312693653994,69.8031277140286,0,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,-4,2,-6,-2,4,0,2,0,-0.096757852077001,-0.134108527131783,0.0419419576191552,-0.276726342710997,-0.0235602094240837,0.821052631578947,-0.451400329489292,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.674,-0.485,"7:7","150/150","Q:T:S:D",3.19623916718558,5.52153426461584e-09,0.548179859875324,5.83063954212496,9.23910743126347,84.0861153416749,1.38810903558899,2.23953024381857e-12,11.6498430682339,8.17279939949528,98.407580019827,6.55288933297668e-17,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR1035363","ERR1035363","lineage4.6","br","Brazil","pnca_p.thr76pro","A","S","THR","TA76","pnca_complex.pdb"
|
|
"T76P","L2","PZA","T","T76",76,"P",NA,"MDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",14.032,-0.382,-0.519,1.15155,-1.623,-0.09,78,85,-0.548,7,7,56,0.325581395348837,"loop",-0.9,3.94,0.0017248814144027,24.4404408647732,24.4404407276145,24.4312693653994,69.8031277140286,0,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,-4,2,-6,-2,4,0,2,0,-0.096757852077001,-0.134108527131783,0.0419419576191552,-0.276726342710997,-0.0235602094240837,0.821052631578947,-0.451400329489292,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.674,-0.485,"7:7","150/150","Q:T:S:D",3.19623916718558,5.52153426461584e-09,0.548179859875324,5.83063954212496,9.23910743126347,84.0861153416749,1.38810903558899,2.23953024381857e-12,11.6498430682339,8.17279939949528,98.407580019827,6.55288933297668e-17,"lineage2","dr_mutations_pyrazinamide","PRO",0,"SAMN03653310,SRS935927","SRR2024893","lineage2.2.2","cn","China","pnca_p.thr76pro","A","S","THR","TA76","pnca_complex.pdb"
|
|
"T76P","L2","PZA","T","T76",76,"P",NA,"MDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",14.032,-0.382,-0.519,1.15155,-1.623,-0.09,78,85,-0.548,7,7,56,0.325581395348837,"loop",-0.9,3.94,0.0017248814144027,24.4404408647732,24.4404407276145,24.4312693653994,69.8031277140286,0,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,-4,2,-6,-2,4,0,2,0,-0.096757852077001,-0.134108527131783,0.0419419576191552,-0.276726342710997,-0.0235602094240837,0.821052631578947,-0.451400329489292,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.674,-0.485,"7:7","150/150","Q:T:S:D",3.19623916718558,5.52153426461584e-09,0.548179859875324,5.83063954212496,9.23910743126347,84.0861153416749,1.38810903558899,2.23953024381857e-12,11.6498430682339,8.17279939949528,98.407580019827,6.55288933297668e-17,"lineage2","dr_mutations_pyrazinamide","PRO",0,"SRR5067348","SRR5067348","lineage2.2.1","vn","Vietnam","pnca_p.thr76pro","A","S","THR","TA76","pnca_complex.pdb"
|
|
"T76P","L2","PZA","T","T76",76,"P",NA,"XDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",14.032,-0.382,-0.519,1.15155,-1.623,-0.09,78,85,-0.548,7,7,56,0.325581395348837,"loop",-0.9,3.94,0.0017248814144027,24.4404408647732,24.4404407276145,24.4312693653994,69.8031277140286,0,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,-4,2,-6,-2,4,0,2,0,-0.096757852077001,-0.134108527131783,0.0419419576191552,-0.276726342710997,-0.0235602094240837,0.821052631578947,-0.451400329489292,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.674,-0.485,"7:7","150/150","Q:T:S:D",3.19623916718558,5.52153426461584e-09,0.548179859875324,5.83063954212496,9.23910743126347,84.0861153416749,1.38810903558899,2.23953024381857e-12,11.6498430682339,8.17279939949528,98.407580019827,6.55288933297668e-17,"lineage2","dr_mutations_pyrazinamide","PRO",0,"SAMN02419608","SRR1172320_SRR1168979_SRR1163166_SRR1163317","lineage2.2.1","by","Belarus","pnca_p.thr76pro","A","S","THR","TA76","pnca_complex.pdb"
|
|
"T76P","L4","PZA","T","T76",76,"P",1,"MDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",14.032,-0.382,-0.519,1.15155,-1.623,-0.09,78,85,-0.548,7,7,56,0.325581395348837,"loop",-0.9,3.94,0.0017248814144027,24.4404408647732,24.4404407276145,24.4312693653994,69.8031277140286,0,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,-4,2,-6,-2,4,0,2,0,-0.096757852077001,-0.134108527131783,0.0419419576191552,-0.276726342710997,-0.0235602094240837,0.821052631578947,-0.451400329489292,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.674,-0.485,"7:7","150/150","Q:T:S:D",3.19623916718558,5.52153426461584e-09,0.548179859875324,5.83063954212496,9.23910743126347,84.0861153416749,1.38810903558899,2.23953024381857e-12,11.6498430682339,8.17279939949528,98.407580019827,6.55288933297668e-17,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR2515130","ERR2515130","lineage4.3.2.1","za","South Africa","pnca_p.thr76pro","A","S","THR","TA76","pnca_complex.pdb"
|
|
"T76P","L2","PZA","T","T76",76,"P",1,"Pre-XDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",14.032,-0.382,-0.519,1.15155,-1.623,-0.09,78,85,-0.548,7,7,56,0.325581395348837,"loop",-0.9,3.94,0.0017248814144027,24.4404408647732,24.4404407276145,24.4312693653994,69.8031277140286,0,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,-4,2,-6,-2,4,0,2,0,-0.096757852077001,-0.134108527131783,0.0419419576191552,-0.276726342710997,-0.0235602094240837,0.821052631578947,-0.451400329489292,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.674,-0.485,"7:7","150/150","Q:T:S:D",3.19623916718558,5.52153426461584e-09,0.548179859875324,5.83063954212496,9.23910743126347,84.0861153416749,1.38810903558899,2.23953024381857e-12,11.6498430682339,8.17279939949528,98.407580019827,6.55288933297668e-17,"lineage2","dr_mutations_pyrazinamide","PRO",0,"ERR2516501","ERR2516501","lineage2.2.1","pe","Peru","pnca_p.thr76pro","A","S","THR","TA76","pnca_complex.pdb"
|
|
"T76P","L4","PZA","T","T76",76,"P",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",14.032,-0.382,-0.519,1.15155,-1.623,-0.09,78,85,-0.548,7,7,56,0.325581395348837,"loop",-0.9,3.94,0.0017248814144027,24.4404408647732,24.4404407276145,24.4312693653994,69.8031277140286,0,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,-4,2,-6,-2,4,0,2,0,-0.096757852077001,-0.134108527131783,0.0419419576191552,-0.276726342710997,-0.0235602094240837,0.821052631578947,-0.451400329489292,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.674,-0.485,"7:7","150/150","Q:T:S:D",3.19623916718558,5.52153426461584e-09,0.548179859875324,5.83063954212496,9.23910743126347,84.0861153416749,1.38810903558899,2.23953024381857e-12,11.6498430682339,8.17279939949528,98.407580019827,6.55288933297668e-17,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR1035290","ERR1035290","lineage4.6","br","Brazil","pnca_p.thr76pro","A","S","THR","TA76","pnca_complex.pdb"
|
|
"T76P","L4","PZA","T","T76",76,"P",NA,"MDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",14.032,-0.382,-0.519,1.15155,-1.623,-0.09,78,85,-0.548,7,7,56,0.325581395348837,"loop",-0.9,3.94,0.0017248814144027,24.4404408647732,24.4404407276145,24.4312693653994,69.8031277140286,0,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,-4,2,-6,-2,4,0,2,0,-0.096757852077001,-0.134108527131783,0.0419419576191552,-0.276726342710997,-0.0235602094240837,0.821052631578947,-0.451400329489292,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.674,-0.485,"7:7","150/150","Q:T:S:D",3.19623916718558,5.52153426461584e-09,0.548179859875324,5.83063954212496,9.23910743126347,84.0861153416749,1.38810903558899,2.23953024381857e-12,11.6498430682339,8.17279939949528,98.407580019827,6.55288933297668e-17,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR233350","ERR233350","lineage4.2.2","et","Ethiopia","pnca_p.thr76pro","A","S","THR","TA76","pnca_complex.pdb"
|
|
"T76P","L4","PZA","T","T76",76,"P",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",14.032,-0.382,-0.519,1.15155,-1.623,-0.09,78,85,-0.548,7,7,56,0.325581395348837,"loop",-0.9,3.94,0.0017248814144027,24.4404408647732,24.4404407276145,24.4312693653994,69.8031277140286,0,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,-4,2,-6,-2,4,0,2,0,-0.096757852077001,-0.134108527131783,0.0419419576191552,-0.276726342710997,-0.0235602094240837,0.821052631578947,-0.451400329489292,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.674,-0.485,"7:7","150/150","Q:T:S:D",3.19623916718558,5.52153426461584e-09,0.548179859875324,5.83063954212496,9.23910743126347,84.0861153416749,1.38810903558899,2.23953024381857e-12,11.6498430682339,8.17279939949528,98.407580019827,6.55288933297668e-17,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR1213904","ERR1213904","lineage4.1.2.1","pe","Peru","pnca_p.thr76pro","A","S","THR","TA76","pnca_complex.pdb"
|
|
"T76P","L4","PZA","T","T76",76,"P",NA,"MDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",14.032,-0.382,-0.519,1.15155,-1.623,-0.09,78,85,-0.548,7,7,56,0.325581395348837,"loop",-0.9,3.94,0.0017248814144027,24.4404408647732,24.4404407276145,24.4312693653994,69.8031277140286,0,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,-4,2,-6,-2,4,0,2,0,-0.096757852077001,-0.134108527131783,0.0419419576191552,-0.276726342710997,-0.0235602094240837,0.821052631578947,-0.451400329489292,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.674,-0.485,"7:7","150/150","Q:T:S:D",3.19623916718558,5.52153426461584e-09,0.548179859875324,5.83063954212496,9.23910743126347,84.0861153416749,1.38810903558899,2.23953024381857e-12,11.6498430682339,8.17279939949528,98.407580019827,6.55288933297668e-17,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR1465932","ERR1465932","lineage4.7","br","Brazil","pnca_p.thr76pro","A","S","THR","TA76","pnca_complex.pdb"
|
|
"T76P","L2","PZA","T","T76",76,"P",1,"MDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",14.032,-0.382,-0.519,1.15155,-1.623,-0.09,78,85,-0.548,7,7,56,0.325581395348837,"loop",-0.9,3.94,0.0017248814144027,24.4404408647732,24.4404407276145,24.4312693653994,69.8031277140286,0,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,-4,2,-6,-2,4,0,2,0,-0.096757852077001,-0.134108527131783,0.0419419576191552,-0.276726342710997,-0.0235602094240837,0.821052631578947,-0.451400329489292,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.674,-0.485,"7:7","150/150","Q:T:S:D",3.19623916718558,5.52153426461584e-09,0.548179859875324,5.83063954212496,9.23910743126347,84.0861153416749,1.38810903558899,2.23953024381857e-12,11.6498430682339,8.17279939949528,98.407580019827,6.55288933297668e-17,"lineage2","dr_mutations_pyrazinamide","PRO",0,"ERR2510696","ERR2510696","lineage2.2.1","it","Italy","pnca_p.thr76pro","A","S","THR","TA76","pnca_complex.pdb"
|
|
"T76P","L2","PZA","T","T76",76,"P",NA,"MDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",14.032,-0.382,-0.519,1.15155,-1.623,-0.09,78,85,-0.548,7,7,56,0.325581395348837,"loop",-0.9,3.94,0.0017248814144027,24.4404408647732,24.4404407276145,24.4312693653994,69.8031277140286,0,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,-4,2,-6,-2,4,0,2,0,-0.096757852077001,-0.134108527131783,0.0419419576191552,-0.276726342710997,-0.0235602094240837,0.821052631578947,-0.451400329489292,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.674,-0.485,"7:7","150/150","Q:T:S:D",3.19623916718558,5.52153426461584e-09,0.548179859875324,5.83063954212496,9.23910743126347,84.0861153416749,1.38810903558899,2.23953024381857e-12,11.6498430682339,8.17279939949528,98.407580019827,6.55288933297668e-17,"lineage2","dr_mutations_pyrazinamide","PRO",0,"SAMN02584652","SRR1168997_SRR1166118","lineage2.2.1","md","Moldova","pnca_p.thr76pro","A","S","THR","TA76","pnca_complex.pdb"
|
|
"T76P","L2","PZA","T","T76",76,"P",0,"MDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",14.032,-0.382,-0.519,1.15155,-1.623,-0.09,78,85,-0.548,7,7,56,0.325581395348837,"loop",-0.9,3.94,0.0017248814144027,24.4404408647732,24.4404407276145,24.4312693653994,69.8031277140286,0,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,-4,2,-6,-2,4,0,2,0,-0.096757852077001,-0.134108527131783,0.0419419576191552,-0.276726342710997,-0.0235602094240837,0.821052631578947,-0.451400329489292,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.674,-0.485,"7:7","150/150","Q:T:S:D",3.19623916718558,5.52153426461584e-09,0.548179859875324,5.83063954212496,9.23910743126347,84.0861153416749,1.38810903558899,2.23953024381857e-12,11.6498430682339,8.17279939949528,98.407580019827,6.55288933297668e-17,"lineage2","dr_mutations_pyrazinamide","PRO",0,"ERR3335749","ERR3335749","lineage2.2.1","pk","Pakistan","pnca_p.thr76pro","A","S","THR","TA76","pnca_complex.pdb"
|
|
"T76P","L4","PZA","T","T76",76,"P",NA,"Pre-MDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",14.032,-0.382,-0.519,1.15155,-1.623,-0.09,78,85,-0.548,7,7,56,0.325581395348837,"loop",-0.9,3.94,0.0017248814144027,24.4404408647732,24.4404407276145,24.4312693653994,69.8031277140286,0,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,-4,2,-6,-2,4,0,2,0,-0.096757852077001,-0.134108527131783,0.0419419576191552,-0.276726342710997,-0.0235602094240837,0.821052631578947,-0.451400329489292,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.674,-0.485,"7:7","150/150","Q:T:S:D",3.19623916718558,5.52153426461584e-09,0.548179859875324,5.83063954212496,9.23910743126347,84.0861153416749,1.38810903558899,2.23953024381857e-12,11.6498430682339,8.17279939949528,98.407580019827,6.55288933297668e-17,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR1213843","ERR1213843","lineage4","kr","South Korea","pnca_p.thr76pro","A","S","THR","TA76","pnca_complex.pdb"
|
|
"T76P","L4","PZA","T","T76",76,"P",NA,"MDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",14.032,-0.382,-0.519,1.15155,-1.623,-0.09,78,85,-0.548,7,7,56,0.325581395348837,"loop",-0.9,3.94,0.0017248814144027,24.4404408647732,24.4404407276145,24.4312693653994,69.8031277140286,0,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,-4,2,-6,-2,4,0,2,0,-0.096757852077001,-0.134108527131783,0.0419419576191552,-0.276726342710997,-0.0235602094240837,0.821052631578947,-0.451400329489292,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.674,-0.485,"7:7","150/150","Q:T:S:D",3.19623916718558,5.52153426461584e-09,0.548179859875324,5.83063954212496,9.23910743126347,84.0861153416749,1.38810903558899,2.23953024381857e-12,11.6498430682339,8.17279939949528,98.407580019827,6.55288933297668e-17,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR1035310","ERR1035310","lineage4.6","br","Brazil","pnca_p.thr76pro","A","S","THR","TA76","pnca_complex.pdb"
|
|
"T76P","L2","PZA","T","T76",76,"P",NA,"MDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",14.032,-0.382,-0.519,1.15155,-1.623,-0.09,78,85,-0.548,7,7,56,0.325581395348837,"loop",-0.9,3.94,0.0017248814144027,24.4404408647732,24.4404407276145,24.4312693653994,69.8031277140286,0,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,-4,2,-6,-2,4,0,2,0,-0.096757852077001,-0.134108527131783,0.0419419576191552,-0.276726342710997,-0.0235602094240837,0.821052631578947,-0.451400329489292,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.674,-0.485,"7:7","150/150","Q:T:S:D",3.19623916718558,5.52153426461584e-09,0.548179859875324,5.83063954212496,9.23910743126347,84.0861153416749,1.38810903558899,2.23953024381857e-12,11.6498430682339,8.17279939949528,98.407580019827,6.55288933297668e-17,"lineage2","dr_mutations_pyrazinamide","PRO",0,"SRR6280311","SRR6280311","lineage2.2.2","cn","China","pnca_p.thr76pro","A","S","THR","TA76","pnca_complex.pdb"
|
|
"T76P","L4","PZA","T","T76",76,"P",NA,"MDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",14.032,-0.382,-0.519,1.15155,-1.623,-0.09,78,85,-0.548,7,7,56,0.325581395348837,"loop",-0.9,3.94,0.0017248814144027,24.4404408647732,24.4404407276145,24.4312693653994,69.8031277140286,0,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,-4,2,-6,-2,4,0,2,0,-0.096757852077001,-0.134108527131783,0.0419419576191552,-0.276726342710997,-0.0235602094240837,0.821052631578947,-0.451400329489292,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.674,-0.485,"7:7","150/150","Q:T:S:D",3.19623916718558,5.52153426461584e-09,0.548179859875324,5.83063954212496,9.23910743126347,84.0861153416749,1.38810903558899,2.23953024381857e-12,11.6498430682339,8.17279939949528,98.407580019827,6.55288933297668e-17,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR1200620","ERR1200620","lineage4.2.2","et","Ethiopia","pnca_p.thr76pro","A","S","THR","TA76","pnca_complex.pdb"
|
|
"T76P","L2","PZA","T","T76",76,"P",1,"MDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",14.032,-0.382,-0.519,1.15155,-1.623,-0.09,78,85,-0.548,7,7,56,0.325581395348837,"loop",-0.9,3.94,0.0017248814144027,24.4404408647732,24.4404407276145,24.4312693653994,69.8031277140286,0,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,-4,2,-6,-2,4,0,2,0,-0.096757852077001,-0.134108527131783,0.0419419576191552,-0.276726342710997,-0.0235602094240837,0.821052631578947,-0.451400329489292,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.674,-0.485,"7:7","150/150","Q:T:S:D",3.19623916718558,5.52153426461584e-09,0.548179859875324,5.83063954212496,9.23910743126347,84.0861153416749,1.38810903558899,2.23953024381857e-12,11.6498430682339,8.17279939949528,98.407580019827,6.55288933297668e-17,"lineage2","dr_mutations_pyrazinamide","PRO",0,"ERR551159,SAMEA2533743,ERS457145","ERR551159","lineage2.2.1","uz","Uzbekistan,Nukus","pnca_p.thr76pro","A","S","THR","TA76","pnca_complex.pdb"
|
|
"T76P","L4","PZA","T","T76",76,"P",NA,"MDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",14.032,-0.382,-0.519,1.15155,-1.623,-0.09,78,85,-0.548,7,7,56,0.325581395348837,"loop",-0.9,3.94,0.0017248814144027,24.4404408647732,24.4404407276145,24.4312693653994,69.8031277140286,0,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,-4,2,-6,-2,4,0,2,0,-0.096757852077001,-0.134108527131783,0.0419419576191552,-0.276726342710997,-0.0235602094240837,0.821052631578947,-0.451400329489292,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.674,-0.485,"7:7","150/150","Q:T:S:D",3.19623916718558,5.52153426461584e-09,0.548179859875324,5.83063954212496,9.23910743126347,84.0861153416749,1.38810903558899,2.23953024381857e-12,11.6498430682339,8.17279939949528,98.407580019827,6.55288933297668e-17,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR2707191","ERR2707191","lineage4.3.4.1","cd","Democratic Republic of Congo","pnca_p.thr76pro","A","S","THR","TA76","pnca_complex.pdb"
|
|
"T76P","L4","PZA","T","T76",76,"P",NA,"MDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",14.032,-0.382,-0.519,1.15155,-1.623,-0.09,78,85,-0.548,7,7,56,0.325581395348837,"loop",-0.9,3.94,0.0017248814144027,24.4404408647732,24.4404407276145,24.4312693653994,69.8031277140286,0,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,-4,2,-6,-2,4,0,2,0,-0.096757852077001,-0.134108527131783,0.0419419576191552,-0.276726342710997,-0.0235602094240837,0.821052631578947,-0.451400329489292,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.674,-0.485,"7:7","150/150","Q:T:S:D",3.19623916718558,5.52153426461584e-09,0.548179859875324,5.83063954212496,9.23910743126347,84.0861153416749,1.38810903558899,2.23953024381857e-12,11.6498430682339,8.17279939949528,98.407580019827,6.55288933297668e-17,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR3275847","ERR3275847","lineage4.2.2","nl","Netherlands","pnca_p.thr76pro","A","S","THR","TA76","pnca_complex.pdb"
|
|
"T76P","L2;L4","PZA","T","T76",76,"P",1,"Pre-MDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",14.032,-0.382,-0.519,1.15155,-1.623,-0.09,78,85,-0.548,7,7,56,0.325581395348837,"loop",-0.9,3.94,0.0017248814144027,24.4404408647732,24.4404407276145,24.4312693653994,69.8031277140286,0,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,-4,2,-6,-2,4,0,2,0,-0.096757852077001,-0.134108527131783,0.0419419576191552,-0.276726342710997,-0.0235602094240837,0.821052631578947,-0.451400329489292,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.674,-0.485,"7:7","150/150","Q:T:S:D",3.19623916718558,5.52153426461584e-09,0.548179859875324,5.83063954212496,9.23910743126347,84.0861153416749,1.38810903558899,2.23953024381857e-12,11.6498430682339,8.17279939949528,98.407580019827,6.55288933297668e-17,"lineage2;lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR067732,0555E-sc-2011-08-25T12:38:30Z-1262331","ERR067732","lineage4.1;lineage2.2","ru","Russia","pnca_p.thr76pro","A","S","THR","TA76","pnca_complex.pdb"
|
|
"T76P","L2","PZA","T","T76",76,"P",1,"Pre-XDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",14.032,-0.382,-0.519,1.15155,-1.623,-0.09,78,85,-0.548,7,7,56,0.325581395348837,"loop",-0.9,3.94,0.0017248814144027,24.4404408647732,24.4404407276145,24.4312693653994,69.8031277140286,0,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,-4,2,-6,-2,4,0,2,0,-0.096757852077001,-0.134108527131783,0.0419419576191552,-0.276726342710997,-0.0235602094240837,0.821052631578947,-0.451400329489292,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.674,-0.485,"7:7","150/150","Q:T:S:D",3.19623916718558,5.52153426461584e-09,0.548179859875324,5.83063954212496,9.23910743126347,84.0861153416749,1.38810903558899,2.23953024381857e-12,11.6498430682339,8.17279939949528,98.407580019827,6.55288933297668e-17,"lineage2","dr_mutations_pyrazinamide","PRO",0,"ERR2516716","ERR2516716","lineage2.2.1","pe","Peru","pnca_p.thr76pro","A","S","THR","TA76","pnca_complex.pdb"
|
|
"T76P","L2","PZA","T","T76",76,"P",1,"Pre-MDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",14.032,-0.382,-0.519,1.15155,-1.623,-0.09,78,85,-0.548,7,7,56,0.325581395348837,"loop",-0.9,3.94,0.0017248814144027,24.4404408647732,24.4404407276145,24.4312693653994,69.8031277140286,0,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,-4,2,-6,-2,4,0,2,0,-0.096757852077001,-0.134108527131783,0.0419419576191552,-0.276726342710997,-0.0235602094240837,0.821052631578947,-0.451400329489292,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.674,-0.485,"7:7","150/150","Q:T:S:D",3.19623916718558,5.52153426461584e-09,0.548179859875324,5.83063954212496,9.23910743126347,84.0861153416749,1.38810903558899,2.23953024381857e-12,11.6498430682339,8.17279939949528,98.407580019827,6.55288933297668e-17,"lineage2","dr_mutations_pyrazinamide","PRO",0,"MDR_10443","SRR6824680","lineage2.2.1","cn","China: Pei County, Xuzhou City, Jiangsu Province","pnca_p.thr76pro","A","S","THR","TA76","pnca_complex.pdb"
|
|
"P77L","L1","PZA","P","P77",77,"L",0,"Sensitive","OM","hydrophilic","hydrophobic","non-polar","non-polar","non-polar","non-polar",13.235,0.067,0.544,0.65747,-0.447,-0.2,18,59,3.113,1,1,94,0.591194968553459,"helix",-0.9,3.75,7.18700589334483e-05,2.42412778478352,0.0001249735077034,0,1.03410070803344e-29,-10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-5,-2,-3,-1,0,0,0,-2,0.0300448430493273,0.462585034013606,0.023946488537941,-0.0762148337595908,-0.0523560209424083,0.189473684210526,0.99775641025641,"Stabilising","Stabilising","Destabilising","Destabilising","Destabilising","effect",1.712,3.125,"1:1","150/150","T:W:Q:E:F:R:L:V:N:P:G:S:A:D:Y:H:K",-8.98740878149639,0.940032862253632,119.468044435489,-0.075228558598776,NA,4692673.51081001,0.384555509373631,1,0,0,188.544222231268,0.999999999999997,"lineage1","other_mutations_pyrazinamide","LEU",0,"SRR2100651,SAMN03647824","SRR2100651","lineage1.1.2","","","pnca_p.pro77leu","A","G","PRO","PA77","pnca_complex.pdb"
|
|
"P77L","L2","PZA","P","P77",77,"L",NA,"Pre-MDR","OM","hydrophilic","hydrophobic","non-polar","non-polar","non-polar","non-polar",13.235,0.067,0.544,0.65747,-0.447,-0.2,18,59,3.113,1,1,94,0.591194968553459,"helix",-0.9,3.75,7.18700589334483e-05,2.42412778478352,0.0001249735077034,0,1.03410070803344e-29,-10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-5,-2,-3,-1,0,0,0,-2,0.0300448430493273,0.462585034013606,0.023946488537941,-0.0762148337595908,-0.0523560209424083,0.189473684210526,0.99775641025641,"Stabilising","Stabilising","Destabilising","Destabilising","Destabilising","effect",1.712,3.125,"1:1","150/150","T:W:Q:E:F:R:L:V:N:P:G:S:A:D:Y:H:K",-8.98740878149639,0.940032862253632,119.468044435489,-0.075228558598776,NA,4692673.51081001,0.384555509373631,1,0,0,188.544222231268,0.999999999999997,"lineage2","other_mutations_pyrazinamide","LEU",0,"SRR5067632","SRR5067632","lineage2.2.1","vn","Vietnam","pnca_p.pro77leu","A","G","PRO","PA77","pnca_complex.pdb"
|
|
"G78A","L2","PZA","G","G78",78,"A",NA,"XDR","OM","hydrophobic","hydrophobic","neutral","non-polar","non-polar","non-polar",9.84,-0.912,0.335,1.30582,-1.378,-0.01,67,80,-0.882,8,8,8,0.0769230769230769,"helix",-0.0666666666666667,4.83,NA,NA,NA,NA,NA,-4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-2,0,0,-2,-2,0,-7,-16,-0.231003039513678,0.284863945578231,0.047560806824059,-0.234953111679454,-0.0026178010471204,0.705263157894737,-0.726523887973641,"Destabilising","Stabilising","Destabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","150/150","G:E:N:D",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage2","other_mutations_pyrazinamide","ALA",0,"BGI_FJ05195,SRR671759","SRR671759","lineage2.2.1","cn","China","pnca_p.gly78ala","A","G","GLY","GA78","pnca_complex.pdb"
|
|
"G78C","L1","PZA","G","G78",78,"C",1,"MDR","DM","hydrophobic","hydrophobic","neutral","neutral","non-polar","non-polar",9.84,-0.281,-1.038,2.40156,-1.186,-0.68,70,85,-0.882,8,8,8,0.0769230769230769,"helix",-0.0666666666666667,4.83,0.0002156101768003,9.70466975178797,9.70465898653048,9.70194990589383,2.29168245016684,-10,0,0,0,0,0,0,0,0,-2,0,-2,0,0,0,0,0,-5,0,-1,-4,-4,0,-9,-19,-0.0711752786220871,-0.268217054263566,0.0874700427596355,-0.202216538789429,-0.178010471204189,0.736842105263158,-0.726523887973641,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","150/150","G:E:N:D",2.27260607808816,0.0634455902260901,1.22442760158496,1.8560559033024,0.929172866365334,208.881603004981,0.986980761010679,0.0776844925942494,1.10966566656461,0.504888890842109,570.372842410328,0.130068862702538,"lineage1","dr_mutations_pyrazinamide","CYS",0,"SAMN03647573,SRR2100400","SRR2100400","lineage1.2.2","","","pnca_p.gly78cys","A","G","GLY","GA78","pnca_complex.pdb"
|
|
"G78C","L4","PZA","G","G78",78,"C",NA,"XDR","DM","hydrophobic","hydrophobic","neutral","neutral","non-polar","non-polar",9.84,-0.281,-1.038,2.40156,-1.186,-0.68,70,85,-0.882,8,8,8,0.0769230769230769,"helix",-0.0666666666666667,4.83,0.0002156101768003,9.70466975178797,9.70465898653048,9.70194990589383,2.29168245016684,-10,0,0,0,0,0,0,0,0,-2,0,-2,0,0,0,0,0,-5,0,-1,-4,-4,0,-9,-19,-0.0711752786220871,-0.268217054263566,0.0874700427596355,-0.202216538789429,-0.178010471204189,0.736842105263158,-0.726523887973641,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","150/150","G:E:N:D",2.27260607808816,0.0634455902260901,1.22442760158496,1.8560559033024,0.929172866365334,208.881603004981,0.986980761010679,0.0776844925942494,1.10966566656461,0.504888890842109,570.372842410328,0.130068862702538,"lineage4","dr_mutations_pyrazinamide","CYS",0,"ERR779901","ERR779901","lineage4.3.4.2","pe","","pnca_p.gly78cys","A","G","GLY","GA78","pnca_complex.pdb"
|
|
"G78C","L1","PZA","G","G78",78,"C",0,"MDR","DM","hydrophobic","hydrophobic","neutral","neutral","non-polar","non-polar",9.84,-0.281,-1.038,2.40156,-1.186,-0.68,70,85,-0.882,8,8,8,0.0769230769230769,"helix",-0.0666666666666667,4.83,0.0002156101768003,9.70466975178797,9.70465898653048,9.70194990589383,2.29168245016684,-10,0,0,0,0,0,0,0,0,-2,0,-2,0,0,0,0,0,-5,0,-1,-4,-4,0,-9,-19,-0.0711752786220871,-0.268217054263566,0.0874700427596355,-0.202216538789429,-0.178010471204189,0.736842105263158,-0.726523887973641,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","150/150","G:E:N:D",2.27260607808816,0.0634455902260901,1.22442760158496,1.8560559033024,0.929172866365334,208.881603004981,0.986980761010679,0.0776844925942494,1.10966566656461,0.504888890842109,570.372842410328,0.130068862702538,"lineage1","dr_mutations_pyrazinamide","CYS",0,"ERR2516751","ERR2516751","lineage1.2.2","gb","UK","pnca_p.gly78cys","A","G","GLY","GA78","pnca_complex.pdb"
|
|
"G78C","L4","PZA","G","G78",78,"C",1,"Pre-XDR","DM","hydrophobic","hydrophobic","neutral","neutral","non-polar","non-polar",9.84,-0.281,-1.038,2.40156,-1.186,-0.68,70,85,-0.882,8,8,8,0.0769230769230769,"helix",-0.0666666666666667,4.83,0.0002156101768003,9.70466975178797,9.70465898653048,9.70194990589383,2.29168245016684,-10,0,0,0,0,0,0,0,0,-2,0,-2,0,0,0,0,0,-5,0,-1,-4,-4,0,-9,-19,-0.0711752786220871,-0.268217054263566,0.0874700427596355,-0.202216538789429,-0.178010471204189,0.736842105263158,-0.726523887973641,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","150/150","G:E:N:D",2.27260607808816,0.0634455902260901,1.22442760158496,1.8560559033024,0.929172866365334,208.881603004981,0.986980761010679,0.0776844925942494,1.10966566656461,0.504888890842109,570.372842410328,0.130068862702538,"lineage4","dr_mutations_pyrazinamide","CYS",0,"ERR1034720","ERR1034720","lineage4","pe","Peru","pnca_p.gly78cys","A","G","GLY","GA78","pnca_complex.pdb"
|
|
"G78R","L4","PZA","G","G78",78,"R",NA,"Pre-MDR","OM","hydrophobic","hydrophilic","neutral","basic","non-polar","pos",9.84,-0.84,-0.272,1.06499,-1.34,-0.13,84,91,-0.882,8,8,8,0.0769230769230769,"helix",-0.0666666666666667,4.83,NA,NA,NA,NA,NA,-42,-20,0,0,-20,0,0,0,0,0,0,2,-4,0,0,0,0,-9,0,-5,-7,-6,0,-11,-13,-0.212765957446809,-0.0702842377260982,0.0387892540009761,-0.22847399829497,-0.0340314136125654,0.884210526315789,-0.726523887973641,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","150/150","G:E:N:D",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage4","other_mutations_pyrazinamide","ARG",0,"ERR2707074","ERR2707074","lineage4.6.1.2","cd","Democratic Republic of Congo","pnca_p.gly78arg","A","G","GLY","GA78","pnca_complex.pdb"
|
|
"G78R","L4","PZA","G","G78",78,"R",NA,"Pre-MDR","OM","hydrophobic","hydrophilic","neutral","basic","non-polar","pos",9.84,-0.84,-0.272,1.06499,-1.34,-0.13,84,91,-0.882,8,8,8,0.0769230769230769,"helix",-0.0666666666666667,4.83,NA,NA,NA,NA,NA,-42,-20,0,0,-20,0,0,0,0,0,0,2,-4,0,0,0,0,-9,0,-5,-7,-6,0,-11,-13,-0.212765957446809,-0.0702842377260982,0.0387892540009761,-0.22847399829497,-0.0340314136125654,0.884210526315789,-0.726523887973641,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","150/150","G:E:N:D",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage4","other_mutations_pyrazinamide","ARG",0,"ERR1199100","ERR1199100","lineage4.6.1.2","cd","Democratic Republic of the Congo","pnca_p.gly78arg","A","G","GLY","GA78","pnca_complex.pdb"
|
|
"G78S","L2","PZA","G","G78",78,"S",1,"MDR","DM","hydrophobic","hydrophilic","neutral","neutral","non-polar","polar",9.84,0.215,-0.859,0.982763,-1.528,-0.4,65,80,-0.882,8,8,8,0.0769230769230769,"helix",-0.0666666666666667,4.83,0.0002156101768003,9.70466975178797,9.7046589865305,9.70194990589383,2.29168245016684,-6,-2,0,0,-2,0,0,0,0,0,0,2,-2,0,0,0,0,-10,0,-8,-2,-2,0,-5,-19,0.0964125560538116,-0.221963824289406,0.0357943676745897,-0.260528559249787,-0.104712041884817,0.684210526315789,-0.726523887973641,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","150/150","G:E:N:D",2.27260607808817,0.0634455902260898,1.22442760158496,1.8560559033024,0.929172866365337,208.881603004981,0.986980761010679,0.0776844925942494,1.10966566656461,0.504888890842109,570.372842410328,0.130068862702538,"lineage2","dr_mutations_pyrazinamide","SER",0,"ERR228039,2180W-sc-2012-10-11T13:38:26Z-1494203","ERR228039","lineage2.2.1","ru","Russia,Samara","pnca_p.gly78ser","A","G","GLY","GA78","pnca_complex.pdb"
|
|
"G78S","L4","PZA","G","G78",78,"S",1,"Pre-XDR","DM","hydrophobic","hydrophilic","neutral","neutral","non-polar","polar",9.84,0.215,-0.859,0.982763,-1.528,-0.4,65,80,-0.882,8,8,8,0.0769230769230769,"helix",-0.0666666666666667,4.83,0.0002156101768003,9.70466975178797,9.7046589865305,9.70194990589383,2.29168245016684,-6,-2,0,0,-2,0,0,0,0,0,0,2,-2,0,0,0,0,-10,0,-8,-2,-2,0,-5,-19,0.0964125560538116,-0.221963824289406,0.0357943676745897,-0.260528559249787,-0.104712041884817,0.684210526315789,-0.726523887973641,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","150/150","G:E:N:D",2.27260607808817,0.0634455902260898,1.22442760158496,1.8560559033024,0.929172866365337,208.881603004981,0.986980761010679,0.0776844925942494,1.10966566656461,0.504888890842109,570.372842410328,0.130068862702538,"lineage4","dr_mutations_pyrazinamide","SER",0,"ERR3335771","ERR3335771","lineage4.5","pk","Pakistan","pnca_p.gly78ser","A","G","GLY","GA78","pnca_complex.pdb"
|
|
"G78S","L3","PZA","G","G78",78,"S",0,"MDR","DM","hydrophobic","hydrophilic","neutral","neutral","non-polar","polar",9.84,0.215,-0.859,0.982763,-1.528,-0.4,65,80,-0.882,8,8,8,0.0769230769230769,"helix",-0.0666666666666667,4.83,0.0002156101768003,9.70466975178797,9.7046589865305,9.70194990589383,2.29168245016684,-6,-2,0,0,-2,0,0,0,0,0,0,2,-2,0,0,0,0,-10,0,-8,-2,-2,0,-5,-19,0.0964125560538116,-0.221963824289406,0.0357943676745897,-0.260528559249787,-0.104712041884817,0.684210526315789,-0.726523887973641,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","150/150","G:E:N:D",2.27260607808817,0.0634455902260898,1.22442760158496,1.8560559033024,0.929172866365337,208.881603004981,0.986980761010679,0.0776844925942494,1.10966566656461,0.504888890842109,570.372842410328,0.130068862702538,"lineage3","dr_mutations_pyrazinamide","SER",0,"ERR2517024","ERR2517024","lineage3","gb","UK","pnca_p.gly78ser","A","G","GLY","GA78","pnca_complex.pdb"
|
|
"G78S","L2","PZA","G","G78",78,"S",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","neutral","neutral","non-polar","polar",9.84,0.215,-0.859,0.982763,-1.528,-0.4,65,80,-0.882,8,8,8,0.0769230769230769,"helix",-0.0666666666666667,4.83,0.0002156101768003,9.70466975178797,9.7046589865305,9.70194990589383,2.29168245016684,-6,-2,0,0,-2,0,0,0,0,0,0,2,-2,0,0,0,0,-10,0,-8,-2,-2,0,-5,-19,0.0964125560538116,-0.221963824289406,0.0357943676745897,-0.260528559249787,-0.104712041884817,0.684210526315789,-0.726523887973641,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","150/150","G:E:N:D",2.27260607808817,0.0634455902260898,1.22442760158496,1.8560559033024,0.929172866365337,208.881603004981,0.986980761010679,0.0776844925942494,1.10966566656461,0.504888890842109,570.372842410328,0.130068862702538,"lineage2","dr_mutations_pyrazinamide","SER",0,"ERR133957,0867T-sc-2012-02-09T18:57:21Z-1355290","ERR133957","lineage2.2.1","ru","Russia","pnca_p.gly78ser","A","G","GLY","GA78","pnca_complex.pdb"
|
|
"G78S","L4","PZA","G","G78",78,"S",NA,"MDR","DM","hydrophobic","hydrophilic","neutral","neutral","non-polar","polar",9.84,0.215,-0.859,0.982763,-1.528,-0.4,65,80,-0.882,8,8,8,0.0769230769230769,"helix",-0.0666666666666667,4.83,0.0002156101768003,9.70466975178797,9.7046589865305,9.70194990589383,2.29168245016684,-6,-2,0,0,-2,0,0,0,0,0,0,2,-2,0,0,0,0,-10,0,-8,-2,-2,0,-5,-19,0.0964125560538116,-0.221963824289406,0.0357943676745897,-0.260528559249787,-0.104712041884817,0.684210526315789,-0.726523887973641,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","150/150","G:E:N:D",2.27260607808817,0.0634455902260898,1.22442760158496,1.8560559033024,0.929172866365337,208.881603004981,0.986980761010679,0.0776844925942494,1.10966566656461,0.504888890842109,570.372842410328,0.130068862702538,"lineage4","dr_mutations_pyrazinamide","SER",0,"SAMN02586033","SRR1173172_SRR1172982_SRR1196480_SRR1184345","lineage4.3.2.1","za","South Africa","pnca_p.gly78ser","A","G","GLY","GA78","pnca_complex.pdb"
|
|
"G78S","L2","PZA","G","G78",78,"S",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","neutral","neutral","non-polar","polar",9.84,0.215,-0.859,0.982763,-1.528,-0.4,65,80,-0.882,8,8,8,0.0769230769230769,"helix",-0.0666666666666667,4.83,0.0002156101768003,9.70466975178797,9.7046589865305,9.70194990589383,2.29168245016684,-6,-2,0,0,-2,0,0,0,0,0,0,2,-2,0,0,0,0,-10,0,-8,-2,-2,0,-5,-19,0.0964125560538116,-0.221963824289406,0.0357943676745897,-0.260528559249787,-0.104712041884817,0.684210526315789,-0.726523887973641,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","150/150","G:E:N:D",2.27260607808817,0.0634455902260898,1.22442760158496,1.8560559033024,0.929172866365337,208.881603004981,0.986980761010679,0.0776844925942494,1.10966566656461,0.504888890842109,570.372842410328,0.130068862702538,"lineage2","dr_mutations_pyrazinamide","SER",0,"SRR671854,BGI_LN373","SRR671854","lineage2.2.1","cn","China","pnca_p.gly78ser","A","G","GLY","GA78","pnca_complex.pdb"
|
|
"G78S","L4","PZA","G","G78",78,"S",NA,"MDR","DM","hydrophobic","hydrophilic","neutral","neutral","non-polar","polar",9.84,0.215,-0.859,0.982763,-1.528,-0.4,65,80,-0.882,8,8,8,0.0769230769230769,"helix",-0.0666666666666667,4.83,0.0002156101768003,9.70466975178797,9.7046589865305,9.70194990589383,2.29168245016684,-6,-2,0,0,-2,0,0,0,0,0,0,2,-2,0,0,0,0,-10,0,-8,-2,-2,0,-5,-19,0.0964125560538116,-0.221963824289406,0.0357943676745897,-0.260528559249787,-0.104712041884817,0.684210526315789,-0.726523887973641,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","150/150","G:E:N:D",2.27260607808817,0.0634455902260898,1.22442760158496,1.8560559033024,0.929172866365337,208.881603004981,0.986980761010679,0.0776844925942494,1.10966566656461,0.504888890842109,570.372842410328,0.130068862702538,"lineage4","dr_mutations_pyrazinamide","SER",0,"SAMN02585996","SRR1196552_SRR1184325_SRR1172865_SRR1175092","lineage4.3.2.1","za","South Africa","pnca_p.gly78ser","A","G","GLY","GA78","pnca_complex.pdb"
|
|
"G78V","L4","PZA","G","G78",78,"V",NA,"MDR","DM","hydrophobic","hydrophobic","neutral","non-polar","non-polar","non-polar",9.84,-0.842,0.114,2.8237,-1.939,-0.82,77,85,-0.882,8,8,8,0.0769230769230769,"helix",-0.0666666666666667,4.83,0.0001437401178668,19.411022297013,511754.463553282,Inf,4.73122070382274,-8,-2,0,0,-2,0,0,0,0,2,0,2,0,0,0,0,0,-17,0,-11,-10,-8,0,-9,-21,-0.213272543059777,0.096938775510204,0.102845300446536,-0.330605285592498,-0.214659685863874,0.810526315789474,-0.726523887973641,"Destabilising","Stabilising","Destabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","150/150","G:E:N:D",13.1456002256219,0.924803768447042,139.277183326662,0.0943844491368702,0.0001628371344429,NA,1.28804840845689,0.0292235860951597,1.53426649183163,0.91081598550184,Inf,0.0296198560706035,"lineage4","dr_mutations_pyrazinamide","VAL",0,"ERR1199111","ERR1199111","lineage4.6.1.2","cd","Democratic Republic of the Congo","pnca_p.gly78val","A","G","GLY","GA78","pnca_complex.pdb"
|
|
"G78V","L4","PZA","G","G78",78,"V",1,"XDR","DM","hydrophobic","hydrophobic","neutral","non-polar","non-polar","non-polar",9.84,-0.842,0.114,2.8237,-1.939,-0.82,77,85,-0.882,8,8,8,0.0769230769230769,"helix",-0.0666666666666667,4.83,0.0001437401178668,19.411022297013,511754.463553282,Inf,4.73122070382274,-8,-2,0,0,-2,0,0,0,0,2,0,2,0,0,0,0,0,-17,0,-11,-10,-8,0,-9,-21,-0.213272543059777,0.096938775510204,0.102845300446536,-0.330605285592498,-0.214659685863874,0.810526315789474,-0.726523887973641,"Destabilising","Stabilising","Destabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","150/150","G:E:N:D",13.1456002256219,0.924803768447042,139.277183326662,0.0943844491368702,0.0001628371344429,NA,1.28804840845689,0.0292235860951597,1.53426649183163,0.91081598550184,Inf,0.0296198560706035,"lineage4","dr_mutations_pyrazinamide","VAL",0,"ERR2516693","ERR2516693","lineage4.1.1","pe","Peru","pnca_p.gly78val","A","G","GLY","GA78","pnca_complex.pdb"
|
|
"G78V","L2","PZA","G","G78",78,"V",1,"Pre-XDR","DM","hydrophobic","hydrophobic","neutral","non-polar","non-polar","non-polar",9.84,-0.842,0.114,2.8237,-1.939,-0.82,77,85,-0.882,8,8,8,0.0769230769230769,"helix",-0.0666666666666667,4.83,0.0001437401178668,19.411022297013,511754.463553282,Inf,4.73122070382274,-8,-2,0,0,-2,0,0,0,0,2,0,2,0,0,0,0,0,-17,0,-11,-10,-8,0,-9,-21,-0.213272543059777,0.096938775510204,0.102845300446536,-0.330605285592498,-0.214659685863874,0.810526315789474,-0.726523887973641,"Destabilising","Stabilising","Destabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","150/150","G:E:N:D",13.1456002256219,0.924803768447042,139.277183326662,0.0943844491368702,0.0001628371344429,NA,1.28804840845689,0.0292235860951597,1.53426649183163,0.91081598550184,Inf,0.0296198560706035,"lineage2","dr_mutations_pyrazinamide","VAL",0,"ERR2516730","ERR2516730","lineage2.2.1","nl","Netherlands","pnca_p.gly78val","A","G","GLY","GA78","pnca_complex.pdb"
|
|
"G78V","L4","PZA","G","G78",78,"V",NA,"MDR","DM","hydrophobic","hydrophobic","neutral","non-polar","non-polar","non-polar",9.84,-0.842,0.114,2.8237,-1.939,-0.82,77,85,-0.882,8,8,8,0.0769230769230769,"helix",-0.0666666666666667,4.83,0.0001437401178668,19.411022297013,511754.463553282,Inf,4.73122070382274,-8,-2,0,0,-2,0,0,0,0,2,0,2,0,0,0,0,0,-17,0,-11,-10,-8,0,-9,-21,-0.213272543059777,0.096938775510204,0.102845300446536,-0.330605285592498,-0.214659685863874,0.810526315789474,-0.726523887973641,"Destabilising","Stabilising","Destabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","150/150","G:E:N:D",13.1456002256219,0.924803768447042,139.277183326662,0.0943844491368702,0.0001628371344429,NA,1.28804840845689,0.0292235860951597,1.53426649183163,0.91081598550184,Inf,0.0296198560706035,"lineage4","dr_mutations_pyrazinamide","VAL",0,"ERR2706948","ERR2706948","lineage4.6.1.2","cd","Democratic Republic of Congo","pnca_p.gly78val","A","G","GLY","GA78","pnca_complex.pdb"
|
|
"A79T","L4","PZA","A","A79",79,"T",0,"Sensitive","OM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",10.663,-0.176,-1.881,-0.0668707,-2.659,-1.58,69,80,-0.886,8,8,1,0.0077519379844961,"helix",-0.7,5.8,0.0001437401178668,1.2119588062211,4.59700131334282e-05,0,1.01056822389159e-25,0,0,0,0,0,0,0,0,0,-2,0,-2,0,0,0,0,0,-1,0,-1,0,-2,0,-2,-5,-0.044579533941236,-0.486046511627907,-0.0128567830500654,-0.453367433930094,-0.413612565445026,0.726315789473684,-0.729818780889621,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","150/150","Q:G:S:E:A:C:V",-9.98752126245055,0.942832958100734,139.277183325396,-0.0717096729269465,NA,144471.70631481,0.0834878586628579,1,0,0,25.8386585962163,0.999999999999746,"lineage4","other_mutations_pyrazinamide","THR",0,"ERR2512531","ERR2512531","lineage4.6","gb","UK","pnca_p.ala79thr","A","G","ALA","AA79","pnca_complex.pdb"
|
|
"A79T","L4","PZA","A","A79",79,"T",0,"Sensitive","OM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",10.663,-0.176,-1.881,-0.0668707,-2.659,-1.58,69,80,-0.886,8,8,1,0.0077519379844961,"helix",-0.7,5.8,0.0001437401178668,1.2119588062211,4.59700131334282e-05,0,1.01056822389159e-25,0,0,0,0,0,0,0,0,0,-2,0,-2,0,0,0,0,0,-1,0,-1,0,-2,0,-2,-5,-0.044579533941236,-0.486046511627907,-0.0128567830500654,-0.453367433930094,-0.413612565445026,0.726315789473684,-0.729818780889621,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","150/150","Q:G:S:E:A:C:V",-9.98752126245055,0.942832958100734,139.277183325396,-0.0717096729269465,NA,144471.70631481,0.0834878586628579,1,0,0,25.8386585962163,0.999999999999746,"lineage4","other_mutations_pyrazinamide","THR",0,"SAMN03647765,SRR2100592","SRR2100592","lineage4.6","","","pnca_p.ala79thr","A","G","ALA","AA79","pnca_complex.pdb"
|
|
"A79V","L3","PZA","A","A79",79,"V",0,"Sensitive","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",10.663,-1.403,-0.186,-0.825109,-1.839,-0.64,25,63,-0.886,8,8,1,0.0077519379844961,"helix",-0.7,5.8,0.0003593502946672,0.484657419083649,1.69068633684892e-05,0,0.177777263899814,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-1,0,-1,0,-2,0,-2,-5,-0.355369807497467,-0.0480620155038759,-0.158638198877182,-0.313554987212276,-0.167539267015707,0.263157894736842,-0.729818780889621,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","150/150","Q:G:S:E:A:C:V",-10.9877909019996,0.939691219428539,145.229797681911,-0.0756579646696576,NA,60.3389082676172,-0.314565134742567,0.596111875058711,0.224672226566594,0,5.29224350433385,0.673290424524484,"lineage3","other_mutations_pyrazinamide","VAL",0,"ERR2512680","ERR2512680","lineage3","gb","UK","pnca_p.ala79val","A","G","ALA","AA79","pnca_complex.pdb"
|
|
"A79V","L4","PZA","A","A79",79,"V",NA,"MDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",10.663,-1.403,-0.186,-0.825109,-1.839,-0.64,25,63,-0.886,8,8,1,0.0077519379844961,"helix",-0.7,5.8,0.0003593502946672,0.484657419083649,1.69068633684892e-05,0,0.177777263899814,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-1,0,-1,0,-2,0,-2,-5,-0.355369807497467,-0.0480620155038759,-0.158638198877182,-0.313554987212276,-0.167539267015707,0.263157894736842,-0.729818780889621,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","150/150","Q:G:S:E:A:C:V",-10.9877909019996,0.939691219428539,145.229797681911,-0.0756579646696576,NA,60.3389082676172,-0.314565134742567,0.596111875058711,0.224672226566594,0,5.29224350433385,0.673290424524484,"lineage4","other_mutations_pyrazinamide","VAL",0,"ERR2707143","ERR2707143","lineage4.3.3","cd","Democratic Republic of Congo","pnca_p.ala79val","A","G","ALA","AA79","pnca_complex.pdb"
|
|
"A79V","L4","PZA","A","A79",79,"V",0,"MDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",10.663,-1.403,-0.186,-0.825109,-1.839,-0.64,25,63,-0.886,8,8,1,0.0077519379844961,"helix",-0.7,5.8,0.0003593502946672,0.484657419083649,1.69068633684892e-05,0,0.177777263899814,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-1,0,-1,0,-2,0,-2,-5,-0.355369807497467,-0.0480620155038759,-0.158638198877182,-0.313554987212276,-0.167539267015707,0.263157894736842,-0.729818780889621,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","150/150","Q:G:S:E:A:C:V",-10.9877909019996,0.939691219428539,145.229797681911,-0.0756579646696576,NA,60.3389082676172,-0.314565134742567,0.596111875058711,0.224672226566594,0,5.29224350433385,0.673290424524484,"lineage4","other_mutations_pyrazinamide","VAL",0,"ERR2516946","ERR2516946","lineage4.3.3","gb","UK","pnca_p.ala79val","A","G","ALA","AA79","pnca_complex.pdb"
|
|
"A79V","L4","PZA","A","A79",79,"V",0,"Sensitive","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",10.663,-1.403,-0.186,-0.825109,-1.839,-0.64,25,63,-0.886,8,8,1,0.0077519379844961,"helix",-0.7,5.8,0.0003593502946672,0.484657419083649,1.69068633684892e-05,0,0.177777263899814,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-1,0,-1,0,-2,0,-2,-5,-0.355369807497467,-0.0480620155038759,-0.158638198877182,-0.313554987212276,-0.167539267015707,0.263157894736842,-0.729818780889621,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","150/150","Q:G:S:E:A:C:V",-10.9877909019996,0.939691219428539,145.229797681911,-0.0756579646696576,NA,60.3389082676172,-0.314565134742567,0.596111875058711,0.224672226566594,0,5.29224350433385,0.673290424524484,"lineage4","other_mutations_pyrazinamide","VAL",0,"ERR2516283","ERR2516283","lineage4.3.3","be","Belgium","pnca_p.ala79val","A","G","ALA","AA79","pnca_complex.pdb"
|
|
"A79V","L4","PZA","A","A79",79,"V",NA,"MDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",10.663,-1.403,-0.186,-0.825109,-1.839,-0.64,25,63,-0.886,8,8,1,0.0077519379844961,"helix",-0.7,5.8,0.0003593502946672,0.484657419083649,1.69068633684892e-05,0,0.177777263899814,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-1,0,-1,0,-2,0,-2,-5,-0.355369807497467,-0.0480620155038759,-0.158638198877182,-0.313554987212276,-0.167539267015707,0.263157894736842,-0.729818780889621,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","150/150","Q:G:S:E:A:C:V",-10.9877909019996,0.939691219428539,145.229797681911,-0.0756579646696576,NA,60.3389082676172,-0.314565134742567,0.596111875058711,0.224672226566594,0,5.29224350433385,0.673290424524484,"lineage4","other_mutations_pyrazinamide","VAL",0,"ERR2707069","ERR2707069","lineage4.3.3","cd","Democratic Republic of Congo","pnca_p.ala79val","A","G","ALA","AA79","pnca_complex.pdb"
|
|
"A79V","L4","PZA","A","A79",79,"V",0,"Pre-MDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",10.663,-1.403,-0.186,-0.825109,-1.839,-0.64,25,63,-0.886,8,8,1,0.0077519379844961,"helix",-0.7,5.8,0.0003593502946672,0.484657419083649,1.69068633684892e-05,0,0.177777263899814,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-1,0,-1,0,-2,0,-2,-5,-0.355369807497467,-0.0480620155038759,-0.158638198877182,-0.313554987212276,-0.167539267015707,0.263157894736842,-0.729818780889621,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","150/150","Q:G:S:E:A:C:V",-10.9877909019996,0.939691219428539,145.229797681911,-0.0756579646696576,NA,60.3389082676172,-0.314565134742567,0.596111875058711,0.224672226566594,0,5.29224350433385,0.673290424524484,"lineage4","other_mutations_pyrazinamide","VAL",0,"ERR2514340","ERR2514340","lineage4.3.3","gb","UK","pnca_p.ala79val","A","G","ALA","AA79","pnca_complex.pdb"
|
|
"A79V","L4","PZA","A","A79",79,"V",0,"Sensitive","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",10.663,-1.403,-0.186,-0.825109,-1.839,-0.64,25,63,-0.886,8,8,1,0.0077519379844961,"helix",-0.7,5.8,0.0003593502946672,0.484657419083649,1.69068633684892e-05,0,0.177777263899814,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-1,0,-1,0,-2,0,-2,-5,-0.355369807497467,-0.0480620155038759,-0.158638198877182,-0.313554987212276,-0.167539267015707,0.263157894736842,-0.729818780889621,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","150/150","Q:G:S:E:A:C:V",-10.9877909019996,0.939691219428539,145.229797681911,-0.0756579646696576,NA,60.3389082676172,-0.314565134742567,0.596111875058711,0.224672226566594,0,5.29224350433385,0.673290424524484,"lineage4","other_mutations_pyrazinamide","VAL",0,"ERR2514486","ERR2514486","lineage4.1.2.1","gb","UK","pnca_p.ala79val","A","G","ALA","AA79","pnca_complex.pdb"
|
|
"F81C","L2","PZA","F","F81",81,"C",1,"XDR","OM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",11.313,-1.003,-1.592,2.56753,-1.315,-1.85,55,75,-0.082,5,5,40,0.166666666666667,"strand",-1.3,4.56,7.18700589334483e-05,9.70142977291842,188179.926264665,Inf,0.763784339928386,26,4,0,0,4,0,0,0,0,-2,0,-2,0,0,0,0,0,2,0,2,0,10,0,10,6,-0.254052684903749,-0.411369509043928,0.0935150314323385,-0.224211423699915,-0.484293193717278,0.578947368421053,-0.0675453047775947,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,0.083,"6:5","150/150","F:M:Y:P:V:L:I",12.1451538387266,0.919026337424239,119.468044436241,0.101660271548249,5.01153666061863e-06,NA,0.986835744238421,0.170978870202674,0.767057556984365,0.124324963210678,Inf,0.382146811758261,"lineage2","other_mutations_pyrazinamide","CYS",0,"ERR234657,2531C-sc-2012-10-11T13:40:33Z-1494335","ERR234657","lineage2.2.1","ru","Russia,Samara","pnca_p.phe81cys","A","B","PHE","FA81","pnca_complex.pdb"
|
|
"F81C","L2","PZA","F","F81",81,"C",NA,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",11.313,-1.003,-1.592,2.56753,-1.315,-1.85,55,75,-0.082,5,5,40,0.166666666666667,"strand",-1.3,4.56,7.18700589334483e-05,9.70142977291842,188179.926264665,Inf,0.763784339928386,26,4,0,0,4,0,0,0,0,-2,0,-2,0,0,0,0,0,2,0,2,0,10,0,10,6,-0.254052684903749,-0.411369509043928,0.0935150314323385,-0.224211423699915,-0.484293193717278,0.578947368421053,-0.0675453047775947,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,0.083,"6:5","150/150","F:M:Y:P:V:L:I",12.1451538387266,0.919026337424239,119.468044436241,0.101660271548249,5.01153666061863e-06,NA,0.986835744238421,0.170978870202674,0.767057556984365,0.124324963210678,Inf,0.382146811758261,"lineage2","other_mutations_pyrazinamide","CYS",0,"ERR1035097","ERR1035097","lineage2.1","vn","Vietnam","pnca_p.phe81cys","A","B","PHE","FA81","pnca_complex.pdb"
|
|
"F81C","L4","PZA","F","F81",81,"C",NA,"MDR","OM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",11.313,-1.003,-1.592,2.56753,-1.315,-1.85,55,75,-0.082,5,5,40,0.166666666666667,"strand",-1.3,4.56,7.18700589334483e-05,9.70142977291842,188179.926264665,Inf,0.763784339928386,26,4,0,0,4,0,0,0,0,-2,0,-2,0,0,0,0,0,2,0,2,0,10,0,10,6,-0.254052684903749,-0.411369509043928,0.0935150314323385,-0.224211423699915,-0.484293193717278,0.578947368421053,-0.0675453047775947,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,0.083,"6:5","150/150","F:M:Y:P:V:L:I",12.1451538387266,0.919026337424239,119.468044436241,0.101660271548249,5.01153666061863e-06,NA,0.986835744238421,0.170978870202674,0.767057556984365,0.124324963210678,Inf,0.382146811758261,"lineage4","other_mutations_pyrazinamide","CYS",0,"ERR3256130","ERR3256130","lineage4.5","ph","Philippines","pnca_p.phe81cys","A","B","PHE","FA81","pnca_complex.pdb"
|
|
"F81S","L2","PZA","F","F81",81,"S",0,"XDR","OM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",11.313,-0.596,-2.584,2.44385,-1.725,-2.58,31,66,-0.082,5,5,40,0.166666666666667,"strand",-1.3,4.56,0.0001437401178668,1.2119588062211,4.59700131334266e-05,0,1.01056822389159e-25,32,4,0,0,4,0,0,0,0,-2,0,-2,0,0,0,0,0,6,0,2,4,12,0,10,8,-0.15096251266464,-0.667700258397933,0.0890103366137574,-0.294117647058824,-0.675392670157068,0.326315789473684,-0.0675453047775947,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,0.083,"6:5","150/150","F:M:Y:P:V:L:I",-9.98752126245058,0.942832958100734,139.277183325397,-0.0717096729269465,NA,144471.70631483,0.0834878586628579,1,0,0,25.8386585962163,0.999999999999746,"lineage2","other_mutations_pyrazinamide","SER",0,"0190H-sc-2011-08-25T12:38:23Z-1262321,ERR067722","ERR067722","lineage2.2.1","ru","Russia,Samara","pnca_p.phe81ser","A","B","PHE","FA81","pnca_complex.pdb"
|
|
"F81S","L2","PZA","F","F81",81,"S",NA,"XDR","OM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",11.313,-0.596,-2.584,2.44385,-1.725,-2.58,31,66,-0.082,5,5,40,0.166666666666667,"strand",-1.3,4.56,0.0001437401178668,1.2119588062211,4.59700131334266e-05,0,1.01056822389159e-25,32,4,0,0,4,0,0,0,0,-2,0,-2,0,0,0,0,0,6,0,2,4,12,0,10,8,-0.15096251266464,-0.667700258397933,0.0890103366137574,-0.294117647058824,-0.675392670157068,0.326315789473684,-0.0675453047775947,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,0.083,"6:5","150/150","F:M:Y:P:V:L:I",-9.98752126245058,0.942832958100734,139.277183325397,-0.0717096729269465,NA,144471.70631483,0.0834878586628579,1,0,0,25.8386585962163,0.999999999999746,"lineage2","other_mutations_pyrazinamide","SER",0,"0517N-sc-2011-09-07T13:18:57Z-1276440,ERR067593","ERR067593","lineage2.2.1","ru","Russia","pnca_p.phe81ser","A","B","PHE","FA81","pnca_complex.pdb"
|
|
"F81S","L4","PZA","F","F81",81,"S",0,"MDR","OM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",11.313,-0.596,-2.584,2.44385,-1.725,-2.58,31,66,-0.082,5,5,40,0.166666666666667,"strand",-1.3,4.56,0.0001437401178668,1.2119588062211,4.59700131334266e-05,0,1.01056822389159e-25,32,4,0,0,4,0,0,0,0,-2,0,-2,0,0,0,0,0,6,0,2,4,12,0,10,8,-0.15096251266464,-0.667700258397933,0.0890103366137574,-0.294117647058824,-0.675392670157068,0.326315789473684,-0.0675453047775947,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,0.083,"6:5","150/150","F:M:Y:P:V:L:I",-9.98752126245058,0.942832958100734,139.277183325397,-0.0717096729269465,NA,144471.70631483,0.0834878586628579,1,0,0,25.8386585962163,0.999999999999746,"lineage4","other_mutations_pyrazinamide","SER",0,"ERR2516468","ERR2516468","lineage4.3.4.2","nl","Netherlands","pnca_p.phe81ser","A","B","PHE","FA81","pnca_complex.pdb"
|
|
"F81V","L4","PZA","F","F81",81,"V",1,"Pre-MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",11.313,-1.967,-1.563,2.08972,-1.962,-1.92,56,75,-0.082,5,5,40,0.166666666666667,"strand",-1.3,4.56,0.0003593502946672,1.21225820016821,1.21225918982515,1.212214074125,7.19297638498975e-25,32,4,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,4,0,2,2,10,0,8,6,-0.49822695035461,-0.403875968992248,0.0761121511666023,-0.334526854219949,-0.50261780104712,0.589473684210526,-0.0675453047775947,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,0.083,"6:5","150/150","F:M:Y:P:V:L:I",0.192485717774876,0.863268405978748,1.11770505415734,0.172215126932565,0.0619550849552711,8.1990567174233,0.083595130527928,1,0,0.0246053772172713,12.260612593354,0.999999999999323,"lineage4","dr_mutations_pyrazinamide","VAL",0,"SRR2101519,SAMN03648766","SRR2101519","lineage4.4.1.1","","","pnca_p.phe81val","A","B","PHE","FA81","pnca_complex.pdb"
|
|
"F81V","L4","PZA","F","F81",81,"V",0,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",11.313,-1.967,-1.563,2.08972,-1.962,-1.92,56,75,-0.082,5,5,40,0.166666666666667,"strand",-1.3,4.56,0.0003593502946672,1.21225820016821,1.21225918982515,1.212214074125,7.19297638498975e-25,32,4,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,4,0,2,2,10,0,8,6,-0.49822695035461,-0.403875968992248,0.0761121511666023,-0.334526854219949,-0.50261780104712,0.589473684210526,-0.0675453047775947,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,0.083,"6:5","150/150","F:M:Y:P:V:L:I",0.192485717774876,0.863268405978748,1.11770505415734,0.172215126932565,0.0619550849552711,8.1990567174233,0.083595130527928,1,0,0.0246053772172713,12.260612593354,0.999999999999323,"lineage4","dr_mutations_pyrazinamide","VAL",0,"ERR2516657","ERR2516657","lineage4.1","nl","Netherlands","pnca_p.phe81val","A","B","PHE","FA81","pnca_complex.pdb"
|
|
"F81V","L4","PZA","F","F81",81,"V",0,"MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",11.313,-1.967,-1.563,2.08972,-1.962,-1.92,56,75,-0.082,5,5,40,0.166666666666667,"strand",-1.3,4.56,0.0003593502946672,1.21225820016821,1.21225918982515,1.212214074125,7.19297638498975e-25,32,4,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,4,0,2,2,10,0,8,6,-0.49822695035461,-0.403875968992248,0.0761121511666023,-0.334526854219949,-0.50261780104712,0.589473684210526,-0.0675453047775947,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,0.083,"6:5","150/150","F:M:Y:P:V:L:I",0.192485717774876,0.863268405978748,1.11770505415734,0.172215126932565,0.0619550849552711,8.1990567174233,0.083595130527928,1,0,0.0246053772172713,12.260612593354,0.999999999999323,"lineage4","dr_mutations_pyrazinamide","VAL",0,"ERR2515155","ERR2515155","lineage4.4.1.1","za","South Africa","pnca_p.phe81val","A","B","PHE","FA81","pnca_complex.pdb"
|
|
"F81V","L3","PZA","F","F81",81,"V",0,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",11.313,-1.967,-1.563,2.08972,-1.962,-1.92,56,75,-0.082,5,5,40,0.166666666666667,"strand",-1.3,4.56,0.0003593502946672,1.21225820016821,1.21225918982515,1.212214074125,7.19297638498975e-25,32,4,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,4,0,2,2,10,0,8,6,-0.49822695035461,-0.403875968992248,0.0761121511666023,-0.334526854219949,-0.50261780104712,0.589473684210526,-0.0675453047775947,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,0.083,"6:5","150/150","F:M:Y:P:V:L:I",0.192485717774876,0.863268405978748,1.11770505415734,0.172215126932565,0.0619550849552711,8.1990567174233,0.083595130527928,1,0,0.0246053772172713,12.260612593354,0.999999999999323,"lineage3","dr_mutations_pyrazinamide","VAL",0,"ERR2510547","ERR2510547","lineage3","pk","Pakistan","pnca_p.phe81val","A","B","PHE","FA81","pnca_complex.pdb"
|
|
"F81V","L2","PZA","F","F81",81,"V",0,"MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",11.313,-1.967,-1.563,2.08972,-1.962,-1.92,56,75,-0.082,5,5,40,0.166666666666667,"strand",-1.3,4.56,0.0003593502946672,1.21225820016821,1.21225918982515,1.212214074125,7.19297638498975e-25,32,4,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,4,0,2,2,10,0,8,6,-0.49822695035461,-0.403875968992248,0.0761121511666023,-0.334526854219949,-0.50261780104712,0.589473684210526,-0.0675453047775947,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,0.083,"6:5","150/150","F:M:Y:P:V:L:I",0.192485717774876,0.863268405978748,1.11770505415734,0.172215126932565,0.0619550849552711,8.1990567174233,0.083595130527928,1,0,0.0246053772172713,12.260612593354,0.999999999999323,"lineage2","dr_mutations_pyrazinamide","VAL",0,"ERS457187","ERR551221_ERR551220","lineage2.2.1","uz","Nukus","pnca_p.phe81val","A","B","PHE","FA81","pnca_complex.pdb"
|
|
"H82D","L4","PZA","H","H82",82,"D",NA,"MDR","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",11.736,0.013,-0.198,1.78228,-1.413,0.3,63,80,-0.684,8,8,33,0.147321428571428,"loop",-0.666666666666667,4.73,0.0001437401178668,4.85029436501262,4.85029432717735,4.84956447904112,0.0881192621863332,26,-20,0,0,-20,0,0,0,0,-2,0,-2,0,0,0,0,0,-1,0,1,0,4,0,4,-2,0.005829596412556,-0.0511627906976744,0.064914517151203,-0.240920716112532,0.168539325842697,0.663157894736842,-0.563426688632619,"Stabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.827,-0.615,"8:7","150/150","D:P:S:A:I:R:V:H",1.57903938912402,0.264247566376723,1.41439286276584,1.11640791656443,0.191756076673665,122.683760399245,0.685768096792206,0.312734154310187,0.504824686014995,0.061763864579114,379.558337204203,0.766581879696361,"lineage4","dr_mutations_pyrazinamide","ASP",0,"ERR751365","ERR751365","lineage4.3.3","pe","","pnca_p.his82asp","A","-","HIS","HA82","pnca_complex.pdb"
|
|
"H82D","L4","PZA","H","H82",82,"D",1,"MDR","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",11.736,0.013,-0.198,1.78228,-1.413,0.3,63,80,-0.684,8,8,33,0.147321428571428,"loop",-0.666666666666667,4.73,0.0001437401178668,4.85029436501262,4.85029432717735,4.84956447904112,0.0881192621863332,26,-20,0,0,-20,0,0,0,0,-2,0,-2,0,0,0,0,0,-1,0,1,0,4,0,4,-2,0.005829596412556,-0.0511627906976744,0.064914517151203,-0.240920716112532,0.168539325842697,0.663157894736842,-0.563426688632619,"Stabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.827,-0.615,"8:7","150/150","D:P:S:A:I:R:V:H",1.57903938912402,0.264247566376723,1.41439286276584,1.11640791656443,0.191756076673665,122.683760399245,0.685768096792206,0.312734154310187,0.504824686014995,0.061763864579114,379.558337204203,0.766581879696361,"lineage4","dr_mutations_pyrazinamide","ASP",0,"ERR040120","ERR040120","lineage4.3.4.2.1","ug","Uganda","pnca_p.his82asp","A","-","HIS","HA82","pnca_complex.pdb"
|
|
"H82D","L4","PZA","H","H82",82,"D",NA,"MDR","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",11.736,0.013,-0.198,1.78228,-1.413,0.3,63,80,-0.684,8,8,33,0.147321428571428,"loop",-0.666666666666667,4.73,0.0001437401178668,4.85029436501262,4.85029432717735,4.84956447904112,0.0881192621863332,26,-20,0,0,-20,0,0,0,0,-2,0,-2,0,0,0,0,0,-1,0,1,0,4,0,4,-2,0.005829596412556,-0.0511627906976744,0.064914517151203,-0.240920716112532,0.168539325842697,0.663157894736842,-0.563426688632619,"Stabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.827,-0.615,"8:7","150/150","D:P:S:A:I:R:V:H",1.57903938912402,0.264247566376723,1.41439286276584,1.11640791656443,0.191756076673665,122.683760399245,0.685768096792206,0.312734154310187,0.504824686014995,0.061763864579114,379.558337204203,0.766581879696361,"lineage4","dr_mutations_pyrazinamide","ASP",0,"ERR1213890","ERR1213890","lineage4.3.4.2.1","rw","Rwanda","pnca_p.his82asp","A","-","HIS","HA82","pnca_complex.pdb"
|
|
"H82D","L4","PZA","H","H82",82,"D",NA,"MDR","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",11.736,0.013,-0.198,1.78228,-1.413,0.3,63,80,-0.684,8,8,33,0.147321428571428,"loop",-0.666666666666667,4.73,0.0001437401178668,4.85029436501262,4.85029432717735,4.84956447904112,0.0881192621863332,26,-20,0,0,-20,0,0,0,0,-2,0,-2,0,0,0,0,0,-1,0,1,0,4,0,4,-2,0.005829596412556,-0.0511627906976744,0.064914517151203,-0.240920716112532,0.168539325842697,0.663157894736842,-0.563426688632619,"Stabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.827,-0.615,"8:7","150/150","D:P:S:A:I:R:V:H",1.57903938912402,0.264247566376723,1.41439286276584,1.11640791656443,0.191756076673665,122.683760399245,0.685768096792206,0.312734154310187,0.504824686014995,0.061763864579114,379.558337204203,0.766581879696361,"lineage4","dr_mutations_pyrazinamide","ASP",0,"ERR1465792","ERR1465792","lineage4.1.2.1","al","Albania","pnca_p.his82asp","A","-","HIS","HA82","pnca_complex.pdb"
|
|
"H82D","L3","PZA","H","H82",82,"D",NA,"MDR","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",11.736,0.013,-0.198,1.78228,-1.413,0.3,63,80,-0.684,8,8,33,0.147321428571428,"loop",-0.666666666666667,4.73,0.0001437401178668,4.85029436501262,4.85029432717735,4.84956447904112,0.0881192621863332,26,-20,0,0,-20,0,0,0,0,-2,0,-2,0,0,0,0,0,-1,0,1,0,4,0,4,-2,0.005829596412556,-0.0511627906976744,0.064914517151203,-0.240920716112532,0.168539325842697,0.663157894736842,-0.563426688632619,"Stabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.827,-0.615,"8:7","150/150","D:P:S:A:I:R:V:H",1.57903938912402,0.264247566376723,1.41439286276584,1.11640791656443,0.191756076673665,122.683760399245,0.685768096792206,0.312734154310187,0.504824686014995,0.061763864579114,379.558337204203,0.766581879696361,"lineage3","dr_mutations_pyrazinamide","ASP",0,"SAMN02414990","SRR1162758_SRR1165373_SRR1166817_SRR1167069","lineage3.1","se","Sweden","pnca_p.his82asp","A","-","HIS","HA82","pnca_complex.pdb"
|
|
"H82D","L2","PZA","H","H82",82,"D",0,"Pre-XDR","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",11.736,0.013,-0.198,1.78228,-1.413,0.3,63,80,-0.684,8,8,33,0.147321428571428,"loop",-0.666666666666667,4.73,0.0001437401178668,4.85029436501262,4.85029432717735,4.84956447904112,0.0881192621863332,26,-20,0,0,-20,0,0,0,0,-2,0,-2,0,0,0,0,0,-1,0,1,0,4,0,4,-2,0.005829596412556,-0.0511627906976744,0.064914517151203,-0.240920716112532,0.168539325842697,0.663157894736842,-0.563426688632619,"Stabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.827,-0.615,"8:7","150/150","D:P:S:A:I:R:V:H",1.57903938912402,0.264247566376723,1.41439286276584,1.11640791656443,0.191756076673665,122.683760399245,0.685768096792206,0.312734154310187,0.504824686014995,0.061763864579114,379.558337204203,0.766581879696361,"lineage2","dr_mutations_pyrazinamide","ASP",0,"ERS457458","ERR551596_ERR551595","lineage2.2.1","uz","Nukus","pnca_p.his82asp","A","-","HIS","HA82","pnca_complex.pdb"
|
|
"H82R","L4","PZA","H","H82",82,"R",NA,"MDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",11.736,-0.111,-0.663,-0.0040868,-0.923,-0.05,52,75,-0.684,8,8,33,0.147321428571428,"loop",-0.666666666666667,4.73,0.0004312203536006,24.2923336141533,24.2923334241601,24.2833096922897,14.1977442691074,-34,-18,0,0,-18,0,0,0,0,0,0,2,-2,0,0,0,0,-5,0,2,-5,2,0,2,-2,-0.0281155015197568,-0.171317829457364,-0.000785741751903407,-0.157374254049446,-0.013089005235602,0.547368421052632,-0.563426688632619,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.827,-0.615,"8:7","150/150","D:P:S:A:I:R:V:H",3.19016080361873,0.0035954281300594,1.09565968954934,2.91163472932996,3.915519774324,465.531063220231,1.38546923679232,0.0007494070007895,3.12528225414311,2.71567844828345,1141.60089496884,0.0001645676755807,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERR2706933","ERR2706933","lineage4.3.4.1","cd","Democratic Republic of Congo","pnca_p.his82arg","A","-","HIS","HA82","pnca_complex.pdb"
|
|
"H82R","L1;L2","PZA","H","H82",82,"R",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",11.736,-0.111,-0.663,-0.0040868,-0.923,-0.05,52,75,-0.684,8,8,33,0.147321428571428,"loop",-0.666666666666667,4.73,0.0004312203536006,24.2923336141533,24.2923334241601,24.2833096922897,14.1977442691074,-34,-18,0,0,-18,0,0,0,0,0,0,2,-2,0,0,0,0,-5,0,2,-5,2,0,2,-2,-0.0281155015197568,-0.171317829457364,-0.000785741751903407,-0.157374254049446,-0.013089005235602,0.547368421052632,-0.563426688632619,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.827,-0.615,"8:7","150/150","D:P:S:A:I:R:V:H",3.19016080361873,0.0035954281300594,1.09565968954934,2.91163472932996,3.915519774324,465.531063220231,1.38546923679232,0.0007494070007895,3.12528225414311,2.71567844828345,1141.60089496884,0.0001645676755807,"lineage1;lineage2","dr_mutations_pyrazinamide","ARG",0,"OU30-FMR163","SRR5341243","lineage2.2.1;lineage1","in","India","pnca_p.his82arg","A","-","HIS","HA82","pnca_complex.pdb"
|
|
"H82R","L2","PZA","H","H82",82,"R",1,"Pre-XDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",11.736,-0.111,-0.663,-0.0040868,-0.923,-0.05,52,75,-0.684,8,8,33,0.147321428571428,"loop",-0.666666666666667,4.73,0.0004312203536006,24.2923336141533,24.2923334241601,24.2833096922897,14.1977442691074,-34,-18,0,0,-18,0,0,0,0,0,0,2,-2,0,0,0,0,-5,0,2,-5,2,0,2,-2,-0.0281155015197568,-0.171317829457364,-0.000785741751903407,-0.157374254049446,-0.013089005235602,0.547368421052632,-0.563426688632619,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.827,-0.615,"8:7","150/150","D:P:S:A:I:R:V:H",3.19016080361873,0.0035954281300594,1.09565968954934,2.91163472932996,3.915519774324,465.531063220231,1.38546923679232,0.0007494070007895,3.12528225414311,2.71567844828345,1141.60089496884,0.0001645676755807,"lineage2","dr_mutations_pyrazinamide","ARG",0,"ERR2516730","ERR2516730","lineage2.2.1","nl","Netherlands","pnca_p.his82arg","A","-","HIS","HA82","pnca_complex.pdb"
|
|
"H82R","L2","PZA","H","H82",82,"R",1,"Pre-XDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",11.736,-0.111,-0.663,-0.0040868,-0.923,-0.05,52,75,-0.684,8,8,33,0.147321428571428,"loop",-0.666666666666667,4.73,0.0004312203536006,24.2923336141533,24.2923334241601,24.2833096922897,14.1977442691074,-34,-18,0,0,-18,0,0,0,0,0,0,2,-2,0,0,0,0,-5,0,2,-5,2,0,2,-2,-0.0281155015197568,-0.171317829457364,-0.000785741751903407,-0.157374254049446,-0.013089005235602,0.547368421052632,-0.563426688632619,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.827,-0.615,"8:7","150/150","D:P:S:A:I:R:V:H",3.19016080361873,0.0035954281300594,1.09565968954934,2.91163472932996,3.915519774324,465.531063220231,1.38546923679232,0.0007494070007895,3.12528225414311,2.71567844828345,1141.60089496884,0.0001645676755807,"lineage2","dr_mutations_pyrazinamide","ARG",0,"1457K-sc-2012-02-21T11:36:44Z-1364726,ERR137234","ERR137234","lineage2.2.1","ru","Russia,Samara","pnca_p.his82arg","A","-","HIS","HA82","pnca_complex.pdb"
|
|
"H82R","L2","PZA","H","H82",82,"R",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",11.736,-0.111,-0.663,-0.0040868,-0.923,-0.05,52,75,-0.684,8,8,33,0.147321428571428,"loop",-0.666666666666667,4.73,0.0004312203536006,24.2923336141533,24.2923334241601,24.2833096922897,14.1977442691074,-34,-18,0,0,-18,0,0,0,0,0,0,2,-2,0,0,0,0,-5,0,2,-5,2,0,2,-2,-0.0281155015197568,-0.171317829457364,-0.000785741751903407,-0.157374254049446,-0.013089005235602,0.547368421052632,-0.563426688632619,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.827,-0.615,"8:7","150/150","D:P:S:A:I:R:V:H",3.19016080361873,0.0035954281300594,1.09565968954934,2.91163472932996,3.915519774324,465.531063220231,1.38546923679232,0.0007494070007895,3.12528225414311,2.71567844828345,1141.60089496884,0.0001645676755807,"lineage2","dr_mutations_pyrazinamide","ARG",0,"SAMN03653288,SRS936017","SRR2024988","lineage2.2.1","cn","China","pnca_p.his82arg","A","-","HIS","HA82","pnca_complex.pdb"
|
|
"H82R","L2","PZA","H","H82",82,"R",1,"Pre-MDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",11.736,-0.111,-0.663,-0.0040868,-0.923,-0.05,52,75,-0.684,8,8,33,0.147321428571428,"loop",-0.666666666666667,4.73,0.0004312203536006,24.2923336141533,24.2923334241601,24.2833096922897,14.1977442691074,-34,-18,0,0,-18,0,0,0,0,0,0,2,-2,0,0,0,0,-5,0,2,-5,2,0,2,-2,-0.0281155015197568,-0.171317829457364,-0.000785741751903407,-0.157374254049446,-0.013089005235602,0.547368421052632,-0.563426688632619,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.827,-0.615,"8:7","150/150","D:P:S:A:I:R:V:H",3.19016080361873,0.0035954281300594,1.09565968954934,2.91163472932996,3.915519774324,465.531063220231,1.38546923679232,0.0007494070007895,3.12528225414311,2.71567844828345,1141.60089496884,0.0001645676755807,"lineage2","dr_mutations_pyrazinamide","ARG",0,"ERR137216,1353X-sc-2012-02-21T11:36:32Z-1364708","ERR137216","lineage2.2.1","ru","Russia","pnca_p.his82arg","A","-","HIS","HA82","pnca_complex.pdb"
|
|
"H82R","L2","PZA","H","H82",82,"R",1,"MDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",11.736,-0.111,-0.663,-0.0040868,-0.923,-0.05,52,75,-0.684,8,8,33,0.147321428571428,"loop",-0.666666666666667,4.73,0.0004312203536006,24.2923336141533,24.2923334241601,24.2833096922897,14.1977442691074,-34,-18,0,0,-18,0,0,0,0,0,0,2,-2,0,0,0,0,-5,0,2,-5,2,0,2,-2,-0.0281155015197568,-0.171317829457364,-0.000785741751903407,-0.157374254049446,-0.013089005235602,0.547368421052632,-0.563426688632619,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.827,-0.615,"8:7","150/150","D:P:S:A:I:R:V:H",3.19016080361873,0.0035954281300594,1.09565968954934,2.91163472932996,3.915519774324,465.531063220231,1.38546923679232,0.0007494070007895,3.12528225414311,2.71567844828345,1141.60089496884,0.0001645676755807,"lineage2","dr_mutations_pyrazinamide","ARG",0,"2567R-sc-2012-10-11T13:40:47Z-1494349,ERR234671","ERR234671","lineage2.2.1","ru","Russia,Samara","pnca_p.his82arg","A","-","HIS","HA82","pnca_complex.pdb"
|
|
"H82R","L3","PZA","H","H82",82,"R",1,"MDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",11.736,-0.111,-0.663,-0.0040868,-0.923,-0.05,52,75,-0.684,8,8,33,0.147321428571428,"loop",-0.666666666666667,4.73,0.0004312203536006,24.2923336141533,24.2923334241601,24.2833096922897,14.1977442691074,-34,-18,0,0,-18,0,0,0,0,0,0,2,-2,0,0,0,0,-5,0,2,-5,2,0,2,-2,-0.0281155015197568,-0.171317829457364,-0.000785741751903407,-0.157374254049446,-0.013089005235602,0.547368421052632,-0.563426688632619,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.827,-0.615,"8:7","150/150","D:P:S:A:I:R:V:H",3.19016080361873,0.0035954281300594,1.09565968954934,2.91163472932996,3.915519774324,465.531063220231,1.38546923679232,0.0007494070007895,3.12528225414311,2.71567844828345,1141.60089496884,0.0001645676755807,"lineage3","dr_mutations_pyrazinamide","ARG",0,"ERR2510513","ERR2510513","lineage3","pk","Pakistan","pnca_p.his82arg","A","-","HIS","HA82","pnca_complex.pdb"
|
|
"H82R","L1","PZA","H","H82",82,"R",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",11.736,-0.111,-0.663,-0.0040868,-0.923,-0.05,52,75,-0.684,8,8,33,0.147321428571428,"loop",-0.666666666666667,4.73,0.0004312203536006,24.2923336141533,24.2923334241601,24.2833096922897,14.1977442691074,-34,-18,0,0,-18,0,0,0,0,0,0,2,-2,0,0,0,0,-5,0,2,-5,2,0,2,-2,-0.0281155015197568,-0.171317829457364,-0.000785741751903407,-0.157374254049446,-0.013089005235602,0.547368421052632,-0.563426688632619,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.827,-0.615,"8:7","150/150","D:P:S:A:I:R:V:H",3.19016080361873,0.0035954281300594,1.09565968954934,2.91163472932996,3.915519774324,465.531063220231,1.38546923679232,0.0007494070007895,3.12528225414311,2.71567844828345,1141.60089496884,0.0001645676755807,"lineage1","dr_mutations_pyrazinamide","ARG",0,"OU29-FMR157","SRR5341244","lineage1.2.2","in","India","pnca_p.his82arg","A","-","HIS","HA82","pnca_complex.pdb"
|
|
"H82R","L1","PZA","H","H82",82,"R",0,"MDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",11.736,-0.111,-0.663,-0.0040868,-0.923,-0.05,52,75,-0.684,8,8,33,0.147321428571428,"loop",-0.666666666666667,4.73,0.0004312203536006,24.2923336141533,24.2923334241601,24.2833096922897,14.1977442691074,-34,-18,0,0,-18,0,0,0,0,0,0,2,-2,0,0,0,0,-5,0,2,-5,2,0,2,-2,-0.0281155015197568,-0.171317829457364,-0.000785741751903407,-0.157374254049446,-0.013089005235602,0.547368421052632,-0.563426688632619,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.827,-0.615,"8:7","150/150","D:P:S:A:I:R:V:H",3.19016080361873,0.0035954281300594,1.09565968954934,2.91163472932996,3.915519774324,465.531063220231,1.38546923679232,0.0007494070007895,3.12528225414311,2.71567844828345,1141.60089496884,0.0001645676755807,"lineage1","dr_mutations_pyrazinamide","ARG",0,"SRR6339663","SRR6339663","lineage1.1.1.1","","UK","pnca_p.his82arg","A","-","HIS","HA82","pnca_complex.pdb"
|
|
"H82R","L2","PZA","H","H82",82,"R",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",11.736,-0.111,-0.663,-0.0040868,-0.923,-0.05,52,75,-0.684,8,8,33,0.147321428571428,"loop",-0.666666666666667,4.73,0.0004312203536006,24.2923336141533,24.2923334241601,24.2833096922897,14.1977442691074,-34,-18,0,0,-18,0,0,0,0,0,0,2,-2,0,0,0,0,-5,0,2,-5,2,0,2,-2,-0.0281155015197568,-0.171317829457364,-0.000785741751903407,-0.157374254049446,-0.013089005235602,0.547368421052632,-0.563426688632619,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.827,-0.615,"8:7","150/150","D:P:S:A:I:R:V:H",3.19016080361873,0.0035954281300594,1.09565968954934,2.91163472932996,3.915519774324,465.531063220231,1.38546923679232,0.0007494070007895,3.12528225414311,2.71567844828345,1141.60089496884,0.0001645676755807,"lineage2","dr_mutations_pyrazinamide","ARG",0,"ERR2516297","ERR2516297","lineage2.2.1","be","Belgium","pnca_p.his82arg","A","-","HIS","HA82","pnca_complex.pdb"
|
|
"H82R","L4","PZA","H","H82",82,"R",NA,"MDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",11.736,-0.111,-0.663,-0.0040868,-0.923,-0.05,52,75,-0.684,8,8,33,0.147321428571428,"loop",-0.666666666666667,4.73,0.0004312203536006,24.2923336141533,24.2923334241601,24.2833096922897,14.1977442691074,-34,-18,0,0,-18,0,0,0,0,0,0,2,-2,0,0,0,0,-5,0,2,-5,2,0,2,-2,-0.0281155015197568,-0.171317829457364,-0.000785741751903407,-0.157374254049446,-0.013089005235602,0.547368421052632,-0.563426688632619,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.827,-0.615,"8:7","150/150","D:P:S:A:I:R:V:H",3.19016080361873,0.0035954281300594,1.09565968954934,2.91163472932996,3.915519774324,465.531063220231,1.38546923679232,0.0007494070007895,3.12528225414311,2.71567844828345,1141.60089496884,0.0001645676755807,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERR2707229","ERR2707229","lineage4.3.2","cd","Democratic Republic of Congo","pnca_p.his82arg","A","-","HIS","HA82","pnca_complex.pdb"
|
|
"H82R","L4","PZA","H","H82",82,"R",NA,"MDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",11.736,-0.111,-0.663,-0.0040868,-0.923,-0.05,52,75,-0.684,8,8,33,0.147321428571428,"loop",-0.666666666666667,4.73,0.0004312203536006,24.2923336141533,24.2923334241601,24.2833096922897,14.1977442691074,-34,-18,0,0,-18,0,0,0,0,0,0,2,-2,0,0,0,0,-5,0,2,-5,2,0,2,-2,-0.0281155015197568,-0.171317829457364,-0.000785741751903407,-0.157374254049446,-0.013089005235602,0.547368421052632,-0.563426688632619,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.827,-0.615,"8:7","150/150","D:P:S:A:I:R:V:H",3.19016080361873,0.0035954281300594,1.09565968954934,2.91163472932996,3.915519774324,465.531063220231,1.38546923679232,0.0007494070007895,3.12528225414311,2.71567844828345,1141.60089496884,0.0001645676755807,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERR2707233","ERR2707233","lineage4.3.4.1","cd","Democratic Republic of Congo","pnca_p.his82arg","A","-","HIS","HA82","pnca_complex.pdb"
|
|
"H82Y","LBOV","PZA","H","H82",82,"Y",NA,"Other","DM","hydrophobic","hydrophobic","basic","neutral","pos","polar",11.736,-0.973,0.591,-0.667302,-0.819,1.23,62,80,-0.684,8,8,33,0.147321428571428,"loop",-0.666666666666667,4.73,NA,NA,NA,NA,NA,-26,-4,0,0,-4,0,0,0,0,0,0,0,0,0,0,0,0,-4,0,0,-6,-2,0,-2,-4,-0.24645390070922,0.502551020408163,-0.128297700530647,-0.139641943734015,0.691011235955056,0.652631578947368,-0.563426688632619,"Destabilising","Stabilising","Stabilising","Destabilising","Stabilising","effect",-0.827,-0.615,"8:7","150/150","D:P:S:A:I:R:V:H",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineageBOV","dr_mutations_pyrazinamide","TYR",0,"SRR5657460","SRR5657460","lineageBOV","mx","","pnca_p.his82tyr","A","-","HIS","HA82","pnca_complex.pdb"
|
|
"L85P","L2","PZA","L","L85",85,"P",NA,"Pre-MDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",12.428,-1.426,-1.891,8.82868,-1.285,-1.32,85,91,-0.734,8,8,9,0.044776119402985,"loop",-0.166666666666667,5.61,0.0005030904125341,29.1630847029077,29.1630732435189,29.1293325978315,18.6717493808583,18,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,-1,-2,4,0,-2,8,-0.361195542046606,-0.488630490956072,0.321559743296498,-0.219096334185848,-0.345549738219895,0.894736842105263,-0.604612850082372,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.872,-0.674,"8:7","150/150","F:V:L:I",3.37290329402598,0.001789077082818,1.07995768762031,3.12318096596747,4.97876379054104,550.894323518834,1.46483345924118,0.0001485295621003,3.828187099348,3.53443753556636,1331.56873199938,1.55265977742841e-05,"lineage2","dr_mutations_pyrazinamide","PRO",0,"SRS797068","SRR1723570","lineage2.2.1","cn","China:InnerMongolia","pnca_p.leu85pro","A","S","LEU","LA85","pnca_complex.pdb"
|
|
"L85P","L4","PZA","L","L85",85,"P",NA,"MDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",12.428,-1.426,-1.891,8.82868,-1.285,-1.32,85,91,-0.734,8,8,9,0.044776119402985,"loop",-0.166666666666667,5.61,0.0005030904125341,29.1630847029077,29.1630732435189,29.1293325978315,18.6717493808583,18,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,-1,-2,4,0,-2,8,-0.361195542046606,-0.488630490956072,0.321559743296498,-0.219096334185848,-0.345549738219895,0.894736842105263,-0.604612850082372,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.872,-0.674,"8:7","150/150","F:V:L:I",3.37290329402598,0.001789077082818,1.07995768762031,3.12318096596747,4.97876379054104,550.894323518834,1.46483345924118,0.0001485295621003,3.828187099348,3.53443753556636,1331.56873199938,1.55265977742841e-05,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR3148200","ERR3148200","lineage4.3.4.2","mx","Mexico","pnca_p.leu85pro","A","S","LEU","LA85","pnca_complex.pdb"
|
|
"L85P","L2","PZA","L","L85",85,"P",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",12.428,-1.426,-1.891,8.82868,-1.285,-1.32,85,91,-0.734,8,8,9,0.044776119402985,"loop",-0.166666666666667,5.61,0.0005030904125341,29.1630847029077,29.1630732435189,29.1293325978315,18.6717493808583,18,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,-1,-2,4,0,-2,8,-0.361195542046606,-0.488630490956072,0.321559743296498,-0.219096334185848,-0.345549738219895,0.894736842105263,-0.604612850082372,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.872,-0.674,"8:7","150/150","F:V:L:I",3.37290329402598,0.001789077082818,1.07995768762031,3.12318096596747,4.97876379054104,550.894323518834,1.46483345924118,0.0001485295621003,3.828187099348,3.53443753556636,1331.56873199938,1.55265977742841e-05,"lineage2","dr_mutations_pyrazinamide","PRO",0,"SAMN03653224,SRS935964","SRR2024918","lineage2.2.1","cn","China","pnca_p.leu85pro","A","S","LEU","LA85","pnca_complex.pdb"
|
|
"L85P","L2","PZA","L","L85",85,"P",1,"MDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",12.428,-1.426,-1.891,8.82868,-1.285,-1.32,85,91,-0.734,8,8,9,0.044776119402985,"loop",-0.166666666666667,5.61,0.0005030904125341,29.1630847029077,29.1630732435189,29.1293325978315,18.6717493808583,18,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,-1,-2,4,0,-2,8,-0.361195542046606,-0.488630490956072,0.321559743296498,-0.219096334185848,-0.345549738219895,0.894736842105263,-0.604612850082372,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.872,-0.674,"8:7","150/150","F:V:L:I",3.37290329402598,0.001789077082818,1.07995768762031,3.12318096596747,4.97876379054104,550.894323518834,1.46483345924118,0.0001485295621003,3.828187099348,3.53443753556636,1331.56873199938,1.55265977742841e-05,"lineage2","dr_mutations_pyrazinamide","PRO",0,"MDR_18163","SRR6824341","lineage2.2.1","cn","China: Yongshun County, Xiangxi City, Hunan Province","pnca_p.leu85pro","A","S","LEU","LA85","pnca_complex.pdb"
|
|
"L85P","L4","PZA","L","L85",85,"P",NA,"XDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",12.428,-1.426,-1.891,8.82868,-1.285,-1.32,85,91,-0.734,8,8,9,0.044776119402985,"loop",-0.166666666666667,5.61,0.0005030904125341,29.1630847029077,29.1630732435189,29.1293325978315,18.6717493808583,18,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,-1,-2,4,0,-2,8,-0.361195542046606,-0.488630490956072,0.321559743296498,-0.219096334185848,-0.345549738219895,0.894736842105263,-0.604612850082372,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.872,-0.674,"8:7","150/150","F:V:L:I",3.37290329402598,0.001789077082818,1.07995768762031,3.12318096596747,4.97876379054104,550.894323518834,1.46483345924118,0.0001485295621003,3.828187099348,3.53443753556636,1331.56873199938,1.55265977742841e-05,"lineage4","dr_mutations_pyrazinamide","PRO",0,"SAMN02628503","SRR1173859_SRR1173580","lineage4.8","ir","Iran","pnca_p.leu85pro","A","S","LEU","LA85","pnca_complex.pdb"
|
|
"L85P","L4","PZA","L","L85",85,"P",NA,"MDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",12.428,-1.426,-1.891,8.82868,-1.285,-1.32,85,91,-0.734,8,8,9,0.044776119402985,"loop",-0.166666666666667,5.61,0.0005030904125341,29.1630847029077,29.1630732435189,29.1293325978315,18.6717493808583,18,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,-1,-2,4,0,-2,8,-0.361195542046606,-0.488630490956072,0.321559743296498,-0.219096334185848,-0.345549738219895,0.894736842105263,-0.604612850082372,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.872,-0.674,"8:7","150/150","F:V:L:I",3.37290329402598,0.001789077082818,1.07995768762031,3.12318096596747,4.97876379054104,550.894323518834,1.46483345924118,0.0001485295621003,3.828187099348,3.53443753556636,1331.56873199938,1.55265977742841e-05,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR751589","ERR751589","lineage4.3.3","pe","","pnca_p.leu85pro","A","S","LEU","LA85","pnca_complex.pdb"
|
|
"L85P","L2","PZA","L","L85",85,"P",NA,"MDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",12.428,-1.426,-1.891,8.82868,-1.285,-1.32,85,91,-0.734,8,8,9,0.044776119402985,"loop",-0.166666666666667,5.61,0.0005030904125341,29.1630847029077,29.1630732435189,29.1293325978315,18.6717493808583,18,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,-1,-2,4,0,-2,8,-0.361195542046606,-0.488630490956072,0.321559743296498,-0.219096334185848,-0.345549738219895,0.894736842105263,-0.604612850082372,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.872,-0.674,"8:7","150/150","F:V:L:I",3.37290329402598,0.001789077082818,1.07995768762031,3.12318096596747,4.97876379054104,550.894323518834,1.46483345924118,0.0001485295621003,3.828187099348,3.53443753556636,1331.56873199938,1.55265977742841e-05,"lineage2","dr_mutations_pyrazinamide","PRO",0,"SRS797215","SRR1723738","lineage2.2.1","cn","China:Hunan","pnca_p.leu85pro","A","S","LEU","LA85","pnca_complex.pdb"
|
|
"L85P","L2","PZA","L","L85",85,"P",1,"Pre-MDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",12.428,-1.426,-1.891,8.82868,-1.285,-1.32,85,91,-0.734,8,8,9,0.044776119402985,"loop",-0.166666666666667,5.61,0.0005030904125341,29.1630847029077,29.1630732435189,29.1293325978315,18.6717493808583,18,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,-1,-2,4,0,-2,8,-0.361195542046606,-0.488630490956072,0.321559743296498,-0.219096334185848,-0.345549738219895,0.894736842105263,-0.604612850082372,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.872,-0.674,"8:7","150/150","F:V:L:I",3.37290329402598,0.001789077082818,1.07995768762031,3.12318096596747,4.97876379054104,550.894323518834,1.46483345924118,0.0001485295621003,3.828187099348,3.53443753556636,1331.56873199938,1.55265977742841e-05,"lineage2","dr_mutations_pyrazinamide","PRO",0,"MDR_5136","SRR6824532","lineage2.2.1","cn","China: Huimin District, Huhhot City, Inner Mongolia Province","pnca_p.leu85pro","A","S","LEU","LA85","pnca_complex.pdb"
|
|
"L85P","L3","PZA","L","L85",85,"P",1,"MDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",12.428,-1.426,-1.891,8.82868,-1.285,-1.32,85,91,-0.734,8,8,9,0.044776119402985,"loop",-0.166666666666667,5.61,0.0005030904125341,29.1630847029077,29.1630732435189,29.1293325978315,18.6717493808583,18,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,-1,-2,4,0,-2,8,-0.361195542046606,-0.488630490956072,0.321559743296498,-0.219096334185848,-0.345549738219895,0.894736842105263,-0.604612850082372,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.872,-0.674,"8:7","150/150","F:V:L:I",3.37290329402598,0.001789077082818,1.07995768762031,3.12318096596747,4.97876379054104,550.894323518834,1.46483345924118,0.0001485295621003,3.828187099348,3.53443753556636,1331.56873199938,1.55265977742841e-05,"lineage3","dr_mutations_pyrazinamide","PRO",0,"SAMN07659885","SRR6046888","lineage3","gb","UK","pnca_p.leu85pro","A","S","LEU","LA85","pnca_complex.pdb"
|
|
"L85P","L4","PZA","L","L85",85,"P",0,"MDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",12.428,-1.426,-1.891,8.82868,-1.285,-1.32,85,91,-0.734,8,8,9,0.044776119402985,"loop",-0.166666666666667,5.61,0.0005030904125341,29.1630847029077,29.1630732435189,29.1293325978315,18.6717493808583,18,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,-1,-2,4,0,-2,8,-0.361195542046606,-0.488630490956072,0.321559743296498,-0.219096334185848,-0.345549738219895,0.894736842105263,-0.604612850082372,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.872,-0.674,"8:7","150/150","F:V:L:I",3.37290329402598,0.001789077082818,1.07995768762031,3.12318096596747,4.97876379054104,550.894323518834,1.46483345924118,0.0001485295621003,3.828187099348,3.53443753556636,1331.56873199938,1.55265977742841e-05,"lineage4","dr_mutations_pyrazinamide","PRO",0,"0991D-sc-2011-10-12T14:59:14Z-1289147,ERR108482","ERR108482","lineage4.1.2.1","ru","Russia,Samara","pnca_p.leu85pro","A","S","LEU","LA85","pnca_complex.pdb"
|
|
"L85P","L2","PZA","L","L85",85,"P",NA,"XDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",12.428,-1.426,-1.891,8.82868,-1.285,-1.32,85,91,-0.734,8,8,9,0.044776119402985,"loop",-0.166666666666667,5.61,0.0005030904125341,29.1630847029077,29.1630732435189,29.1293325978315,18.6717493808583,18,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,-1,-2,4,0,-2,8,-0.361195542046606,-0.488630490956072,0.321559743296498,-0.219096334185848,-0.345549738219895,0.894736842105263,-0.604612850082372,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.872,-0.674,"8:7","150/150","F:V:L:I",3.37290329402598,0.001789077082818,1.07995768762031,3.12318096596747,4.97876379054104,550.894323518834,1.46483345924118,0.0001485295621003,3.828187099348,3.53443753556636,1331.56873199938,1.55265977742841e-05,"lineage2","dr_mutations_pyrazinamide","PRO",0,"BGI_LN236,SRR671799","SRR671799","lineage2.2.1","cn","China","pnca_p.leu85pro","A","S","LEU","LA85","pnca_complex.pdb"
|
|
"L85P","L4","PZA","L","L85",85,"P",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",12.428,-1.426,-1.891,8.82868,-1.285,-1.32,85,91,-0.734,8,8,9,0.044776119402985,"loop",-0.166666666666667,5.61,0.0005030904125341,29.1630847029077,29.1630732435189,29.1293325978315,18.6717493808583,18,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,-1,-2,4,0,-2,8,-0.361195542046606,-0.488630490956072,0.321559743296498,-0.219096334185848,-0.345549738219895,0.894736842105263,-0.604612850082372,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.872,-0.674,"8:7","150/150","F:V:L:I",3.37290329402598,0.001789077082818,1.07995768762031,3.12318096596747,4.97876379054104,550.894323518834,1.46483345924118,0.0001485295621003,3.828187099348,3.53443753556636,1331.56873199938,1.55265977742841e-05,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR1035070","ERR1035070","lineage4.4.1.1;lineage4.3.2.1","za","South Africa","pnca_p.leu85pro","A","S","LEU","LA85","pnca_complex.pdb"
|
|
"L85P","L4","PZA","L","L85",85,"P",1,"MDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",12.428,-1.426,-1.891,8.82868,-1.285,-1.32,85,91,-0.734,8,8,9,0.044776119402985,"loop",-0.166666666666667,5.61,0.0005030904125341,29.1630847029077,29.1630732435189,29.1293325978315,18.6717493808583,18,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,-1,-2,4,0,-2,8,-0.361195542046606,-0.488630490956072,0.321559743296498,-0.219096334185848,-0.345549738219895,0.894736842105263,-0.604612850082372,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.872,-0.674,"8:7","150/150","F:V:L:I",3.37290329402598,0.001789077082818,1.07995768762031,3.12318096596747,4.97876379054104,550.894323518834,1.46483345924118,0.0001485295621003,3.828187099348,3.53443753556636,1331.56873199938,1.55265977742841e-05,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR2041732","ERR2041732","lineage4.8","rs","Serbia","pnca_p.leu85pro","A","S","LEU","LA85","pnca_complex.pdb"
|
|
"L85P","L1","PZA","L","L85",85,"P",NA,"MDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",12.428,-1.426,-1.891,8.82868,-1.285,-1.32,85,91,-0.734,8,8,9,0.044776119402985,"loop",-0.166666666666667,5.61,0.0005030904125341,29.1630847029077,29.1630732435189,29.1293325978315,18.6717493808583,18,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,-1,-2,4,0,-2,8,-0.361195542046606,-0.488630490956072,0.321559743296498,-0.219096334185848,-0.345549738219895,0.894736842105263,-0.604612850082372,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.872,-0.674,"8:7","150/150","F:V:L:I",3.37290329402598,0.001789077082818,1.07995768762031,3.12318096596747,4.97876379054104,550.894323518834,1.46483345924118,0.0001485295621003,3.828187099348,3.53443753556636,1331.56873199938,1.55265977742841e-05,"lineage1","dr_mutations_pyrazinamide","PRO",0,"SRR8380928","SRR8380928","lineage1.1.2","in","India","pnca_p.leu85pro","A","S","LEU","LA85","pnca_complex.pdb"
|
|
"L85P","L2","PZA","L","L85",85,"P",1,"Pre-XDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",12.428,-1.426,-1.891,8.82868,-1.285,-1.32,85,91,-0.734,8,8,9,0.044776119402985,"loop",-0.166666666666667,5.61,0.0005030904125341,29.1630847029077,29.1630732435189,29.1293325978315,18.6717493808583,18,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,-1,-2,4,0,-2,8,-0.361195542046606,-0.488630490956072,0.321559743296498,-0.219096334185848,-0.345549738219895,0.894736842105263,-0.604612850082372,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.872,-0.674,"8:7","150/150","F:V:L:I",3.37290329402598,0.001789077082818,1.07995768762031,3.12318096596747,4.97876379054104,550.894323518834,1.46483345924118,0.0001485295621003,3.828187099348,3.53443753556636,1331.56873199938,1.55265977742841e-05,"lineage2","dr_mutations_pyrazinamide","PRO",0,"ERR551956","ERR551956","lineage2.2.1","ru","Russia","pnca_p.leu85pro","A","S","LEU","LA85","pnca_complex.pdb"
|
|
"L85P","L3","PZA","L","L85",85,"P",1,"Pre-MDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",12.428,-1.426,-1.891,8.82868,-1.285,-1.32,85,91,-0.734,8,8,9,0.044776119402985,"loop",-0.166666666666667,5.61,0.0005030904125341,29.1630847029077,29.1630732435189,29.1293325978315,18.6717493808583,18,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,-1,-2,4,0,-2,8,-0.361195542046606,-0.488630490956072,0.321559743296498,-0.219096334185848,-0.345549738219895,0.894736842105263,-0.604612850082372,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.872,-0.674,"8:7","150/150","F:V:L:I",3.37290329402598,0.001789077082818,1.07995768762031,3.12318096596747,4.97876379054104,550.894323518834,1.46483345924118,0.0001485295621003,3.828187099348,3.53443753556636,1331.56873199938,1.55265977742841e-05,"lineage3","dr_mutations_pyrazinamide","PRO",0,"ERR2510351","ERR2510351","lineage3","pk","Pakistan","pnca_p.leu85pro","A","S","LEU","LA85","pnca_complex.pdb"
|
|
"L85P","L2","PZA","L","L85",85,"P",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",12.428,-1.426,-1.891,8.82868,-1.285,-1.32,85,91,-0.734,8,8,9,0.044776119402985,"loop",-0.166666666666667,5.61,0.0005030904125341,29.1630847029077,29.1630732435189,29.1293325978315,18.6717493808583,18,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,-1,-2,4,0,-2,8,-0.361195542046606,-0.488630490956072,0.321559743296498,-0.219096334185848,-0.345549738219895,0.894736842105263,-0.604612850082372,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.872,-0.674,"8:7","150/150","F:V:L:I",3.37290329402598,0.001789077082818,1.07995768762031,3.12318096596747,4.97876379054104,550.894323518834,1.46483345924118,0.0001485295621003,3.828187099348,3.53443753556636,1331.56873199938,1.55265977742841e-05,"lineage2","dr_mutations_pyrazinamide","PRO",0,"BGI_315,SRR671724","SRR671724","lineage2.2.1","cn","China","pnca_p.leu85pro","A","S","LEU","LA85","pnca_complex.pdb"
|
|
"L85R","L2","PZA","L","L85",85,"R",0,"MDR","DM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",12.428,-0.808,-1.371,2.99904,-1.503,-0.82,84,91,-0.734,8,8,9,0.044776119402985,"loop",-0.166666666666667,5.61,0.0009343107661348,26.7869510135135,26.7869506340703,26.7708032978517,37.2159659891988,-50,-32,0,0,-32,0,0,0,0,0,0,0,0,0,0,0,0,-3,0,1,-5,-8,0,-6,-6,-0.204660587639311,-0.354263565891473,0.109231564915246,-0.256265984654731,-0.214659685863874,0.884210526315789,-0.604612850082372,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.872,-0.674,"8:7","150/150","F:V:L:I",3.28791485229524,1.90630753051074e-05,0.768996545261044,4.27559118770699,7.18677177006371,173.199151011595,1.42792328347145,1.9896368453757e-07,6.70122618511891,5.83859157504838,247.443798048456,1.05744462378296e-09,"lineage2","dr_mutations_pyrazinamide","ARG",0,"ERR2516799","ERR2516799","lineage2.2.1","gb","UK","pnca_p.leu85arg","A","S","LEU","LA85","pnca_complex.pdb"
|
|
"L85R","L4","PZA","L","L85",85,"R",NA,"MDR","DM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",12.428,-0.808,-1.371,2.99904,-1.503,-0.82,84,91,-0.734,8,8,9,0.044776119402985,"loop",-0.166666666666667,5.61,0.0009343107661348,26.7869510135135,26.7869506340703,26.7708032978517,37.2159659891988,-50,-32,0,0,-32,0,0,0,0,0,0,0,0,0,0,0,0,-3,0,1,-5,-8,0,-6,-6,-0.204660587639311,-0.354263565891473,0.109231564915246,-0.256265984654731,-0.214659685863874,0.884210526315789,-0.604612850082372,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.872,-0.674,"8:7","150/150","F:V:L:I",3.28791485229524,1.90630753051074e-05,0.768996545261044,4.27559118770699,7.18677177006371,173.199151011595,1.42792328347145,1.9896368453757e-07,6.70122618511891,5.83859157504838,247.443798048456,1.05744462378296e-09,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERR2707176","ERR2707176","lineage4.3.4.1","cd","Democratic Republic of Congo","pnca_p.leu85arg","A","S","LEU","LA85","pnca_complex.pdb"
|
|
"L85R","L2","PZA","L","L85",85,"R",1,"Pre-XDR","DM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",12.428,-0.808,-1.371,2.99904,-1.503,-0.82,84,91,-0.734,8,8,9,0.044776119402985,"loop",-0.166666666666667,5.61,0.0009343107661348,26.7869510135135,26.7869506340703,26.7708032978517,37.2159659891988,-50,-32,0,0,-32,0,0,0,0,0,0,0,0,0,0,0,0,-3,0,1,-5,-8,0,-6,-6,-0.204660587639311,-0.354263565891473,0.109231564915246,-0.256265984654731,-0.214659685863874,0.884210526315789,-0.604612850082372,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.872,-0.674,"8:7","150/150","F:V:L:I",3.28791485229524,1.90630753051074e-05,0.768996545261044,4.27559118770699,7.18677177006371,173.199151011595,1.42792328347145,1.9896368453757e-07,6.70122618511891,5.83859157504838,247.443798048456,1.05744462378296e-09,"lineage2","dr_mutations_pyrazinamide","ARG",0,"ERR2517071","ERR2517071","lineage2.2.1","gb","UK","pnca_p.leu85arg","A","S","LEU","LA85","pnca_complex.pdb"
|
|
"L85R","L2","PZA","L","L85",85,"R",NA,"MDR","DM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",12.428,-0.808,-1.371,2.99904,-1.503,-0.82,84,91,-0.734,8,8,9,0.044776119402985,"loop",-0.166666666666667,5.61,0.0009343107661348,26.7869510135135,26.7869506340703,26.7708032978517,37.2159659891988,-50,-32,0,0,-32,0,0,0,0,0,0,0,0,0,0,0,0,-3,0,1,-5,-8,0,-6,-6,-0.204660587639311,-0.354263565891473,0.109231564915246,-0.256265984654731,-0.214659685863874,0.884210526315789,-0.604612850082372,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.872,-0.674,"8:7","150/150","F:V:L:I",3.28791485229524,1.90630753051074e-05,0.768996545261044,4.27559118770699,7.18677177006371,173.199151011595,1.42792328347145,1.9896368453757e-07,6.70122618511891,5.83859157504838,247.443798048456,1.05744462378296e-09,"lineage2","dr_mutations_pyrazinamide","ARG",0,"SRS796992","SRR1723482_SRR1723483","lineage2.2.1","cn","China:Jiangxi","pnca_p.leu85arg","A","S","LEU","LA85","pnca_complex.pdb"
|
|
"L85R","L2","PZA","L","L85",85,"R",0,"MDR","DM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",12.428,-0.808,-1.371,2.99904,-1.503,-0.82,84,91,-0.734,8,8,9,0.044776119402985,"loop",-0.166666666666667,5.61,0.0009343107661348,26.7869510135135,26.7869506340703,26.7708032978517,37.2159659891988,-50,-32,0,0,-32,0,0,0,0,0,0,0,0,0,0,0,0,-3,0,1,-5,-8,0,-6,-6,-0.204660587639311,-0.354263565891473,0.109231564915246,-0.256265984654731,-0.214659685863874,0.884210526315789,-0.604612850082372,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.872,-0.674,"8:7","150/150","F:V:L:I",3.28791485229524,1.90630753051074e-05,0.768996545261044,4.27559118770699,7.18677177006371,173.199151011595,1.42792328347145,1.9896368453757e-07,6.70122618511891,5.83859157504838,247.443798048456,1.05744462378296e-09,"lineage2","dr_mutations_pyrazinamide","ARG",0,"ERR2516748","ERR2516748","lineage2.2.1","gb","UK","pnca_p.leu85arg","A","S","LEU","LA85","pnca_complex.pdb"
|
|
"L85R","L2","PZA","L","L85",85,"R",NA,"MDR","DM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",12.428,-0.808,-1.371,2.99904,-1.503,-0.82,84,91,-0.734,8,8,9,0.044776119402985,"loop",-0.166666666666667,5.61,0.0009343107661348,26.7869510135135,26.7869506340703,26.7708032978517,37.2159659891988,-50,-32,0,0,-32,0,0,0,0,0,0,0,0,0,0,0,0,-3,0,1,-5,-8,0,-6,-6,-0.204660587639311,-0.354263565891473,0.109231564915246,-0.256265984654731,-0.214659685863874,0.884210526315789,-0.604612850082372,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.872,-0.674,"8:7","150/150","F:V:L:I",3.28791485229524,1.90630753051074e-05,0.768996545261044,4.27559118770699,7.18677177006371,173.199151011595,1.42792328347145,1.9896368453757e-07,6.70122618511891,5.83859157504838,247.443798048456,1.05744462378296e-09,"lineage2","dr_mutations_pyrazinamide","ARG",0,"ERR1034982","ERR1034982","lineage2.2.1.1","za","South Africa","pnca_p.leu85arg","A","S","LEU","LA85","pnca_complex.pdb"
|
|
"L85R","L2","PZA","L","L85",85,"R",1,"Pre-XDR","DM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",12.428,-0.808,-1.371,2.99904,-1.503,-0.82,84,91,-0.734,8,8,9,0.044776119402985,"loop",-0.166666666666667,5.61,0.0009343107661348,26.7869510135135,26.7869506340703,26.7708032978517,37.2159659891988,-50,-32,0,0,-32,0,0,0,0,0,0,0,0,0,0,0,0,-3,0,1,-5,-8,0,-6,-6,-0.204660587639311,-0.354263565891473,0.109231564915246,-0.256265984654731,-0.214659685863874,0.884210526315789,-0.604612850082372,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.872,-0.674,"8:7","150/150","F:V:L:I",3.28791485229524,1.90630753051074e-05,0.768996545261044,4.27559118770699,7.18677177006371,173.199151011595,1.42792328347145,1.9896368453757e-07,6.70122618511891,5.83859157504838,247.443798048456,1.05744462378296e-09,"lineage2","dr_mutations_pyrazinamide","ARG",0,"MDR_12259","SRR6824500","lineage2.2.1","cn","China: Ma'anshan City, Anhui Province","pnca_p.leu85arg","A","S","LEU","LA85","pnca_complex.pdb"
|
|
"L85R","L2","PZA","L","L85",85,"R",1,"Pre-XDR","DM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",12.428,-0.808,-1.371,2.99904,-1.503,-0.82,84,91,-0.734,8,8,9,0.044776119402985,"loop",-0.166666666666667,5.61,0.0009343107661348,26.7869510135135,26.7869506340703,26.7708032978517,37.2159659891988,-50,-32,0,0,-32,0,0,0,0,0,0,0,0,0,0,0,0,-3,0,1,-5,-8,0,-6,-6,-0.204660587639311,-0.354263565891473,0.109231564915246,-0.256265984654731,-0.214659685863874,0.884210526315789,-0.604612850082372,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.872,-0.674,"8:7","150/150","F:V:L:I",3.28791485229524,1.90630753051074e-05,0.768996545261044,4.27559118770699,7.18677177006371,173.199151011595,1.42792328347145,1.9896368453757e-07,6.70122618511891,5.83859157504838,247.443798048456,1.05744462378296e-09,"lineage2","dr_mutations_pyrazinamide","ARG",0,"ERS1831673","ERR2041931","lineage2.2.1","","Germany_extendedCAO","pnca_p.leu85arg","A","S","LEU","LA85","pnca_complex.pdb"
|
|
"L85R","L2","PZA","L","L85",85,"R",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",12.428,-0.808,-1.371,2.99904,-1.503,-0.82,84,91,-0.734,8,8,9,0.044776119402985,"loop",-0.166666666666667,5.61,0.0009343107661348,26.7869510135135,26.7869506340703,26.7708032978517,37.2159659891988,-50,-32,0,0,-32,0,0,0,0,0,0,0,0,0,0,0,0,-3,0,1,-5,-8,0,-6,-6,-0.204660587639311,-0.354263565891473,0.109231564915246,-0.256265984654731,-0.214659685863874,0.884210526315789,-0.604612850082372,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.872,-0.674,"8:7","150/150","F:V:L:I",3.28791485229524,1.90630753051074e-05,0.768996545261044,4.27559118770699,7.18677177006371,173.199151011595,1.42792328347145,1.9896368453757e-07,6.70122618511891,5.83859157504838,247.443798048456,1.05744462378296e-09,"lineage2","dr_mutations_pyrazinamide","ARG",0,"ERR502930","ERR502930","lineage2.2.1","","","pnca_p.leu85arg","A","S","LEU","LA85","pnca_complex.pdb"
|
|
"L85R","L2","PZA","L","L85",85,"R",1,"Pre-XDR","DM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",12.428,-0.808,-1.371,2.99904,-1.503,-0.82,84,91,-0.734,8,8,9,0.044776119402985,"loop",-0.166666666666667,5.61,0.0009343107661348,26.7869510135135,26.7869506340703,26.7708032978517,37.2159659891988,-50,-32,0,0,-32,0,0,0,0,0,0,0,0,0,0,0,0,-3,0,1,-5,-8,0,-6,-6,-0.204660587639311,-0.354263565891473,0.109231564915246,-0.256265984654731,-0.214659685863874,0.884210526315789,-0.604612850082372,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.872,-0.674,"8:7","150/150","F:V:L:I",3.28791485229524,1.90630753051074e-05,0.768996545261044,4.27559118770699,7.18677177006371,173.199151011595,1.42792328347145,1.9896368453757e-07,6.70122618511891,5.83859157504838,247.443798048456,1.05744462378296e-09,"lineage2","dr_mutations_pyrazinamide","ARG",0,"SAMN10961361","SRR8651592","lineage2.2.2","cn","China:Wenzhou","pnca_p.leu85arg","A","S","LEU","LA85","pnca_complex.pdb"
|
|
"L85R","L2","PZA","L","L85",85,"R",1,"Pre-XDR","DM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",12.428,-0.808,-1.371,2.99904,-1.503,-0.82,84,91,-0.734,8,8,9,0.044776119402985,"loop",-0.166666666666667,5.61,0.0009343107661348,26.7869510135135,26.7869506340703,26.7708032978517,37.2159659891988,-50,-32,0,0,-32,0,0,0,0,0,0,0,0,0,0,0,0,-3,0,1,-5,-8,0,-6,-6,-0.204660587639311,-0.354263565891473,0.109231564915246,-0.256265984654731,-0.214659685863874,0.884210526315789,-0.604612850082372,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.872,-0.674,"8:7","150/150","F:V:L:I",3.28791485229524,1.90630753051074e-05,0.768996545261044,4.27559118770699,7.18677177006371,173.199151011595,1.42792328347145,1.9896368453757e-07,6.70122618511891,5.83859157504838,247.443798048456,1.05744462378296e-09,"lineage2","dr_mutations_pyrazinamide","ARG",0,"ERR2516399","ERR2516399","lineage2.2.1","be","Belgium","pnca_p.leu85arg","A","S","LEU","LA85","pnca_complex.pdb"
|
|
"L85R","L4","PZA","L","L85",85,"R",NA,"MDR","DM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",12.428,-0.808,-1.371,2.99904,-1.503,-0.82,84,91,-0.734,8,8,9,0.044776119402985,"loop",-0.166666666666667,5.61,0.0009343107661348,26.7869510135135,26.7869506340703,26.7708032978517,37.2159659891988,-50,-32,0,0,-32,0,0,0,0,0,0,0,0,0,0,0,0,-3,0,1,-5,-8,0,-6,-6,-0.204660587639311,-0.354263565891473,0.109231564915246,-0.256265984654731,-0.214659685863874,0.884210526315789,-0.604612850082372,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.872,-0.674,"8:7","150/150","F:V:L:I",3.28791485229524,1.90630753051074e-05,0.768996545261044,4.27559118770699,7.18677177006371,173.199151011595,1.42792328347145,1.9896368453757e-07,6.70122618511891,5.83859157504838,247.443798048456,1.05744462378296e-09,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERR1023398","ERR1023398","lineage4.3.3","","","pnca_p.leu85arg","A","S","LEU","LA85","pnca_complex.pdb"
|
|
"L85R","L4","PZA","L","L85",85,"R",1,"Pre-XDR","DM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",12.428,-0.808,-1.371,2.99904,-1.503,-0.82,84,91,-0.734,8,8,9,0.044776119402985,"loop",-0.166666666666667,5.61,0.0009343107661348,26.7869510135135,26.7869506340703,26.7708032978517,37.2159659891988,-50,-32,0,0,-32,0,0,0,0,0,0,0,0,0,0,0,0,-3,0,1,-5,-8,0,-6,-6,-0.204660587639311,-0.354263565891473,0.109231564915246,-0.256265984654731,-0.214659685863874,0.884210526315789,-0.604612850082372,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.872,-0.674,"8:7","150/150","F:V:L:I",3.28791485229524,1.90630753051074e-05,0.768996545261044,4.27559118770699,7.18677177006371,173.199151011595,1.42792328347145,1.9896368453757e-07,6.70122618511891,5.83859157504838,247.443798048456,1.05744462378296e-09,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERR2516851","ERR2516851","lineage4.2.1","gb","UK","pnca_p.leu85arg","A","S","LEU","LA85","pnca_complex.pdb"
|
|
"L85R","L4","PZA","L","L85",85,"R",1,"MDR","DM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",12.428,-0.808,-1.371,2.99904,-1.503,-0.82,84,91,-0.734,8,8,9,0.044776119402985,"loop",-0.166666666666667,5.61,0.0009343107661348,26.7869510135135,26.7869506340703,26.7708032978517,37.2159659891988,-50,-32,0,0,-32,0,0,0,0,0,0,0,0,0,0,0,0,-3,0,1,-5,-8,0,-6,-6,-0.204660587639311,-0.354263565891473,0.109231564915246,-0.256265984654731,-0.214659685863874,0.884210526315789,-0.604612850082372,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.872,-0.674,"8:7","150/150","F:V:L:I",3.28791485229524,1.90630753051074e-05,0.768996545261044,4.27559118770699,7.18677177006371,173.199151011595,1.42792328347145,1.9896368453757e-07,6.70122618511891,5.83859157504838,247.443798048456,1.05744462378296e-09,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERR2515390","ERR2515390","lineage4.3.3","za","South Africa","pnca_p.leu85arg","A","S","LEU","LA85","pnca_complex.pdb"
|
|
"L85R","L2","PZA","L","L85",85,"R",1,"XDR","DM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",12.428,-0.808,-1.371,2.99904,-1.503,-0.82,84,91,-0.734,8,8,9,0.044776119402985,"loop",-0.166666666666667,5.61,0.0009343107661348,26.7869510135135,26.7869506340703,26.7708032978517,37.2159659891988,-50,-32,0,0,-32,0,0,0,0,0,0,0,0,0,0,0,0,-3,0,1,-5,-8,0,-6,-6,-0.204660587639311,-0.354263565891473,0.109231564915246,-0.256265984654731,-0.214659685863874,0.884210526315789,-0.604612850082372,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.872,-0.674,"8:7","150/150","F:V:L:I",3.28791485229524,1.90630753051074e-05,0.768996545261044,4.27559118770699,7.18677177006371,173.199151011595,1.42792328347145,1.9896368453757e-07,6.70122618511891,5.83859157504838,247.443798048456,1.05744462378296e-09,"lineage2","dr_mutations_pyrazinamide","ARG",0,"ERR133951,0824X-sc-2012-02-09T18:57:16Z-1355284","ERR133951","lineage2.2.1","ru","Russia,Samara","pnca_p.leu85arg","A","S","LEU","LA85","pnca_complex.pdb"
|
|
"L85R","L2","PZA","L","L85",85,"R",1,"Pre-XDR","DM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",12.428,-0.808,-1.371,2.99904,-1.503,-0.82,84,91,-0.734,8,8,9,0.044776119402985,"loop",-0.166666666666667,5.61,0.0009343107661348,26.7869510135135,26.7869506340703,26.7708032978517,37.2159659891988,-50,-32,0,0,-32,0,0,0,0,0,0,0,0,0,0,0,0,-3,0,1,-5,-8,0,-6,-6,-0.204660587639311,-0.354263565891473,0.109231564915246,-0.256265984654731,-0.214659685863874,0.884210526315789,-0.604612850082372,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.872,-0.674,"8:7","150/150","F:V:L:I",3.28791485229524,1.90630753051074e-05,0.768996545261044,4.27559118770699,7.18677177006371,173.199151011595,1.42792328347145,1.9896368453757e-07,6.70122618511891,5.83859157504838,247.443798048456,1.05744462378296e-09,"lineage2","dr_mutations_pyrazinamide","ARG",0,"ERS1831671","ERR2041937","lineage2.2.1","","Germany_extendedCAO","pnca_p.leu85arg","A","S","LEU","LA85","pnca_complex.pdb"
|
|
"L85R","L2","PZA","L","L85",85,"R",1,"Pre-XDR","DM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",12.428,-0.808,-1.371,2.99904,-1.503,-0.82,84,91,-0.734,8,8,9,0.044776119402985,"loop",-0.166666666666667,5.61,0.0009343107661348,26.7869510135135,26.7869506340703,26.7708032978517,37.2159659891988,-50,-32,0,0,-32,0,0,0,0,0,0,0,0,0,0,0,0,-3,0,1,-5,-8,0,-6,-6,-0.204660587639311,-0.354263565891473,0.109231564915246,-0.256265984654731,-0.214659685863874,0.884210526315789,-0.604612850082372,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.872,-0.674,"8:7","150/150","F:V:L:I",3.28791485229524,1.90630753051074e-05,0.768996545261044,4.27559118770699,7.18677177006371,173.199151011595,1.42792328347145,1.9896368453757e-07,6.70122618511891,5.83859157504838,247.443798048456,1.05744462378296e-09,"lineage2","dr_mutations_pyrazinamide","ARG",0,"ERR2517092","ERR2517092","lineage2.2.1","gb","UK","pnca_p.leu85arg","A","S","LEU","LA85","pnca_complex.pdb"
|
|
"L85R","L4","PZA","L","L85",85,"R",NA,"MDR","DM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",12.428,-0.808,-1.371,2.99904,-1.503,-0.82,84,91,-0.734,8,8,9,0.044776119402985,"loop",-0.166666666666667,5.61,0.0009343107661348,26.7869510135135,26.7869506340703,26.7708032978517,37.2159659891988,-50,-32,0,0,-32,0,0,0,0,0,0,0,0,0,0,0,0,-3,0,1,-5,-8,0,-6,-6,-0.204660587639311,-0.354263565891473,0.109231564915246,-0.256265984654731,-0.214659685863874,0.884210526315789,-0.604612850082372,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.872,-0.674,"8:7","150/150","F:V:L:I",3.28791485229524,1.90630753051074e-05,0.768996545261044,4.27559118770699,7.18677177006371,173.199151011595,1.42792328347145,1.9896368453757e-07,6.70122618511891,5.83859157504838,247.443798048456,1.05744462378296e-09,"lineage4","dr_mutations_pyrazinamide","ARG",0,"SAMN02414852","SRR1165456_SRR1163030_SRR1163196_SRR1167120","lineage4.3.3","se","Sweden","pnca_p.leu85arg","A","S","LEU","LA85","pnca_complex.pdb"
|
|
"L85R","L2","PZA","L","L85",85,"R",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",12.428,-0.808,-1.371,2.99904,-1.503,-0.82,84,91,-0.734,8,8,9,0.044776119402985,"loop",-0.166666666666667,5.61,0.0009343107661348,26.7869510135135,26.7869506340703,26.7708032978517,37.2159659891988,-50,-32,0,0,-32,0,0,0,0,0,0,0,0,0,0,0,0,-3,0,1,-5,-8,0,-6,-6,-0.204660587639311,-0.354263565891473,0.109231564915246,-0.256265984654731,-0.214659685863874,0.884210526315789,-0.604612850082372,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.872,-0.674,"8:7","150/150","F:V:L:I",3.28791485229524,1.90630753051074e-05,0.768996545261044,4.27559118770699,7.18677177006371,173.199151011595,1.42792328347145,1.9896368453757e-07,6.70122618511891,5.83859157504838,247.443798048456,1.05744462378296e-09,"lineage2","dr_mutations_pyrazinamide","ARG",0,"SRS797018","SRR1723516_SRR1723515","lineage2.2.1","cn","China:Anhui","pnca_p.leu85arg","A","S","LEU","LA85","pnca_complex.pdb"
|
|
"L85R","L2","PZA","L","L85",85,"R",1,"Pre-XDR","DM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",12.428,-0.808,-1.371,2.99904,-1.503,-0.82,84,91,-0.734,8,8,9,0.044776119402985,"loop",-0.166666666666667,5.61,0.0009343107661348,26.7869510135135,26.7869506340703,26.7708032978517,37.2159659891988,-50,-32,0,0,-32,0,0,0,0,0,0,0,0,0,0,0,0,-3,0,1,-5,-8,0,-6,-6,-0.204660587639311,-0.354263565891473,0.109231564915246,-0.256265984654731,-0.214659685863874,0.884210526315789,-0.604612850082372,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.872,-0.674,"8:7","150/150","F:V:L:I",3.28791485229524,1.90630753051074e-05,0.768996545261044,4.27559118770699,7.18677177006371,173.199151011595,1.42792328347145,1.9896368453757e-07,6.70122618511891,5.83859157504838,247.443798048456,1.05744462378296e-09,"lineage2","dr_mutations_pyrazinamide","ARG",0,"ERS1831672","ERR2041932","lineage2.2.1","","Germany_extendedCAO","pnca_p.leu85arg","A","S","LEU","LA85","pnca_complex.pdb"
|
|
"L85R","L4","PZA","L","L85",85,"R",NA,"MDR","DM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",12.428,-0.808,-1.371,2.99904,-1.503,-0.82,84,91,-0.734,8,8,9,0.044776119402985,"loop",-0.166666666666667,5.61,0.0009343107661348,26.7869510135135,26.7869506340703,26.7708032978517,37.2159659891988,-50,-32,0,0,-32,0,0,0,0,0,0,0,0,0,0,0,0,-3,0,1,-5,-8,0,-6,-6,-0.204660587639311,-0.354263565891473,0.109231564915246,-0.256265984654731,-0.214659685863874,0.884210526315789,-0.604612850082372,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.872,-0.674,"8:7","150/150","F:V:L:I",3.28791485229524,1.90630753051074e-05,0.768996545261044,4.27559118770699,7.18677177006371,173.199151011595,1.42792328347145,1.9896368453757e-07,6.70122618511891,5.83859157504838,247.443798048456,1.05744462378296e-09,"lineage4","dr_mutations_pyrazinamide","ARG",0,"SAMN02414905","SRR1166913_SRR1162793_SRR1146383_SRR1144777","lineage4.3.3","se","Sweden","pnca_p.leu85arg","A","S","LEU","LA85","pnca_complex.pdb"
|
|
"D86G","L4","PZA","D","D86",86,"G",0,"Other","OM","hydrophilic","hydrophobic","acidic","neutral","neg","non-polar",17.129,-1.107,-0.094,2.19531,-0.796,0.24,15,59,1.31,1,1,97,0.50259067357513,"loop",-0.133333333333333,3.88,7.18700589334483e-05,2.42412778478352,0.0001249735077034,0,1.03410070803344e-29,4,14,0,0,14,0,0,0,0,4,0,2,2,0,0,0,0,3,0,1,2,2,0,3,13,-0.280395136778116,-0.0242894056847545,0.0799579688080478,-0.135720375106564,0.134831460674157,0.157894736842105,0.419871794871795,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",0.842,1.712,"2:1","150/150","D:P:A:G:S:T:K:R:N:L:V:Q:E:F:H",-8.98740878149642,0.940032862253633,119.468044435491,-0.0752285585987753,NA,4692673.51081135,0.384555509373631,1,0,0,188.544222231268,0.999999999999997,"lineage4","other_mutations_pyrazinamide","GLY",0,"ERR2513489","ERR2513489","lineage4.1.2","gb","UK","pnca_p.asp86gly","A","-","ASP","DA86","pnca_complex.pdb"
|
|
"T87M","L4","PZA","T","T87",87,"M",0,"Pre-MDR","OM","hydrophobic","hydrophobic","neutral","non-polar","polar","non-polar",17.594,-0.692,-0.4,-1.95982,-0.061,-0.37,-47,72,1.003,1,1,86,0.5,"loop",-1.66666666666667,3.72,0.0007905706482679,0.220184187397302,6.21642915145485e-06,0,1.2237252074576,-22,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,-5,0,-1,-4,-2,0,-2,0,-0.175278622087133,-0.103359173126615,-0.376801507344459,-0.0104006820119352,-0.0968586387434555,-0.505376344086022,0.321474358974359,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","neutral",0.59,1.183,"3:1","150/150","I:R:L:V:N:Q:F:E:W:T:K:H:Y:D:P:G:M:A:S",-11.9883149074727,0.940801856882948,161.432542873449,-0.0742620706710335,NA,0.975080220739854,-0.657213873251097,0.23001103975255,0.638251318814789,0,1.93160031351699,0.268630815579749,"lineage4","other_mutations_pyrazinamide","MET",0,"1322-04,ERS458560","ERR553130_ERR553131","lineage4.8","","","pnca_p.thr87met","A","-","THR","TA87","pnca_complex.pdb"
|
|
"T87M","L4","PZA","T","T87",87,"M",0,"Sensitive","OM","hydrophobic","hydrophobic","neutral","non-polar","polar","non-polar",17.594,-0.692,-0.4,-1.95982,-0.061,-0.37,-47,72,1.003,1,1,86,0.5,"loop",-1.66666666666667,3.72,0.0007905706482679,0.220184187397302,6.21642915145485e-06,0,1.2237252074576,-22,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,-5,0,-1,-4,-2,0,-2,0,-0.175278622087133,-0.103359173126615,-0.376801507344459,-0.0104006820119352,-0.0968586387434555,-0.505376344086022,0.321474358974359,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","neutral",0.59,1.183,"3:1","150/150","I:R:L:V:N:Q:F:E:W:T:K:H:Y:D:P:G:M:A:S",-11.9883149074727,0.940801856882948,161.432542873449,-0.0742620706710335,NA,0.975080220739854,-0.657213873251097,0.23001103975255,0.638251318814789,0,1.93160031351699,0.268630815579749,"lineage4","other_mutations_pyrazinamide","MET",0,"SAMEA1019052,ERR046831","ERR046831","lineage4.8","gb","United Kingdom,UK","pnca_p.thr87met","A","-","THR","TA87","pnca_complex.pdb"
|
|
"T87M","L4","PZA","T","T87",87,"M",NA,"Pre-MDR","OM","hydrophobic","hydrophobic","neutral","non-polar","polar","non-polar",17.594,-0.692,-0.4,-1.95982,-0.061,-0.37,-47,72,1.003,1,1,86,0.5,"loop",-1.66666666666667,3.72,0.0007905706482679,0.220184187397302,6.21642915145485e-06,0,1.2237252074576,-22,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,-5,0,-1,-4,-2,0,-2,0,-0.175278622087133,-0.103359173126615,-0.376801507344459,-0.0104006820119352,-0.0968586387434555,-0.505376344086022,0.321474358974359,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","neutral",0.59,1.183,"3:1","150/150","I:R:L:V:N:Q:F:E:W:T:K:H:Y:D:P:G:M:A:S",-11.9883149074727,0.940801856882948,161.432542873449,-0.0742620706710335,NA,0.975080220739854,-0.657213873251097,0.23001103975255,0.638251318814789,0,1.93160031351699,0.268630815579749,"lineage4","other_mutations_pyrazinamide","MET",0,"ERS1212442","ERR1465845_ERR1465969","lineage4.8","","unknown","pnca_p.thr87met","A","-","THR","TA87","pnca_complex.pdb"
|
|
"T87M","L4","PZA","T","T87",87,"M",0,"Sensitive","OM","hydrophobic","hydrophobic","neutral","non-polar","polar","non-polar",17.594,-0.692,-0.4,-1.95982,-0.061,-0.37,-47,72,1.003,1,1,86,0.5,"loop",-1.66666666666667,3.72,0.0007905706482679,0.220184187397302,6.21642915145485e-06,0,1.2237252074576,-22,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,-5,0,-1,-4,-2,0,-2,0,-0.175278622087133,-0.103359173126615,-0.376801507344459,-0.0104006820119352,-0.0968586387434555,-0.505376344086022,0.321474358974359,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","neutral",0.59,1.183,"3:1","150/150","I:R:L:V:N:Q:F:E:W:T:K:H:Y:D:P:G:M:A:S",-11.9883149074727,0.940801856882948,161.432542873449,-0.0742620706710335,NA,0.975080220739854,-0.657213873251097,0.23001103975255,0.638251318814789,0,1.93160031351699,0.268630815579749,"lineage4","other_mutations_pyrazinamide","MET",0,"SAMEA2535234,ERR553235","ERR553235","lineage4.8","","","pnca_p.thr87met","A","-","THR","TA87","pnca_complex.pdb"
|
|
"T87M","L4","PZA","T","T87",87,"M",0,"Sensitive","OM","hydrophobic","hydrophobic","neutral","non-polar","polar","non-polar",17.594,-0.692,-0.4,-1.95982,-0.061,-0.37,-47,72,1.003,1,1,86,0.5,"loop",-1.66666666666667,3.72,0.0007905706482679,0.220184187397302,6.21642915145485e-06,0,1.2237252074576,-22,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,-5,0,-1,-4,-2,0,-2,0,-0.175278622087133,-0.103359173126615,-0.376801507344459,-0.0104006820119352,-0.0968586387434555,-0.505376344086022,0.321474358974359,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","neutral",0.59,1.183,"3:1","150/150","I:R:L:V:N:Q:F:E:W:T:K:H:Y:D:P:G:M:A:S",-11.9883149074727,0.940801856882948,161.432542873449,-0.0742620706710335,NA,0.975080220739854,-0.657213873251097,0.23001103975255,0.638251318814789,0,1.93160031351699,0.268630815579749,"lineage4","other_mutations_pyrazinamide","MET",0,"ERR2517558","ERR2517558","lineage4.8","nl","Netherlands","pnca_p.thr87met","A","-","THR","TA87","pnca_complex.pdb"
|
|
"T87M","L4","PZA","T","T87",87,"M",NA,"Sensitive","OM","hydrophobic","hydrophobic","neutral","non-polar","polar","non-polar",17.594,-0.692,-0.4,-1.95982,-0.061,-0.37,-47,72,1.003,1,1,86,0.5,"loop",-1.66666666666667,3.72,0.0007905706482679,0.220184187397302,6.21642915145485e-06,0,1.2237252074576,-22,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,-5,0,-1,-4,-2,0,-2,0,-0.175278622087133,-0.103359173126615,-0.376801507344459,-0.0104006820119352,-0.0968586387434555,-0.505376344086022,0.321474358974359,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","neutral",0.59,1.183,"3:1","150/150","I:R:L:V:N:Q:F:E:W:T:K:H:Y:D:P:G:M:A:S",-11.9883149074727,0.940801856882948,161.432542873449,-0.0742620706710335,NA,0.975080220739854,-0.657213873251097,0.23001103975255,0.638251318814789,0,1.93160031351699,0.268630815579749,"lineage4","other_mutations_pyrazinamide","MET",0,"ERR2446337","ERR2446337","lineage4.8","nl","Netherlands","pnca_p.thr87met","A","-","THR","TA87","pnca_complex.pdb"
|
|
"T87M","L4","PZA","T","T87",87,"M",0,"Sensitive","OM","hydrophobic","hydrophobic","neutral","non-polar","polar","non-polar",17.594,-0.692,-0.4,-1.95982,-0.061,-0.37,-47,72,1.003,1,1,86,0.5,"loop",-1.66666666666667,3.72,0.0007905706482679,0.220184187397302,6.21642915145485e-06,0,1.2237252074576,-22,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,-5,0,-1,-4,-2,0,-2,0,-0.175278622087133,-0.103359173126615,-0.376801507344459,-0.0104006820119352,-0.0968586387434555,-0.505376344086022,0.321474358974359,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","neutral",0.59,1.183,"3:1","150/150","I:R:L:V:N:Q:F:E:W:T:K:H:Y:D:P:G:M:A:S",-11.9883149074727,0.940801856882948,161.432542873449,-0.0742620706710335,NA,0.975080220739854,-0.657213873251097,0.23001103975255,0.638251318814789,0,1.93160031351699,0.268630815579749,"lineage4","other_mutations_pyrazinamide","MET",0,"ERR039342,SAMEA961662","ERR039342","lineage4.8","gb","United Kingdom,UK","pnca_p.thr87met","A","-","THR","TA87","pnca_complex.pdb"
|
|
"T87M","L4","PZA","T","T87",87,"M",0,"Sensitive","OM","hydrophobic","hydrophobic","neutral","non-polar","polar","non-polar",17.594,-0.692,-0.4,-1.95982,-0.061,-0.37,-47,72,1.003,1,1,86,0.5,"loop",-1.66666666666667,3.72,0.0007905706482679,0.220184187397302,6.21642915145485e-06,0,1.2237252074576,-22,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,-5,0,-1,-4,-2,0,-2,0,-0.175278622087133,-0.103359173126615,-0.376801507344459,-0.0104006820119352,-0.0968586387434555,-0.505376344086022,0.321474358974359,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","neutral",0.59,1.183,"3:1","150/150","I:R:L:V:N:Q:F:E:W:T:K:H:Y:D:P:G:M:A:S",-11.9883149074727,0.940801856882948,161.432542873449,-0.0742620706710335,NA,0.975080220739854,-0.657213873251097,0.23001103975255,0.638251318814789,0,1.93160031351699,0.268630815579749,"lineage4","other_mutations_pyrazinamide","MET",0,"ERR039341,SAMEA961661","ERR039341","lineage4.8","gb","United Kingdom,unknown,UK","pnca_p.thr87met","A","-","THR","TA87","pnca_complex.pdb"
|
|
"T87M","L4","PZA","T","T87",87,"M",0,"Sensitive","OM","hydrophobic","hydrophobic","neutral","non-polar","polar","non-polar",17.594,-0.692,-0.4,-1.95982,-0.061,-0.37,-47,72,1.003,1,1,86,0.5,"loop",-1.66666666666667,3.72,0.0007905706482679,0.220184187397302,6.21642915145485e-06,0,1.2237252074576,-22,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,-5,0,-1,-4,-2,0,-2,0,-0.175278622087133,-0.103359173126615,-0.376801507344459,-0.0104006820119352,-0.0968586387434555,-0.505376344086022,0.321474358974359,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","neutral",0.59,1.183,"3:1","150/150","I:R:L:V:N:Q:F:E:W:T:K:H:Y:D:P:G:M:A:S",-11.9883149074727,0.940801856882948,161.432542873449,-0.0742620706710335,NA,0.975080220739854,-0.657213873251097,0.23001103975255,0.638251318814789,0,1.93160031351699,0.268630815579749,"lineage4","other_mutations_pyrazinamide","MET",0,"SAMN03647759,SRR2100586","SRR2100586","lineage4.8","","","pnca_p.thr87met","A","-","THR","TA87","pnca_complex.pdb"
|
|
"T87M","L4","PZA","T","T87",87,"M",0,"Sensitive","OM","hydrophobic","hydrophobic","neutral","non-polar","polar","non-polar",17.594,-0.692,-0.4,-1.95982,-0.061,-0.37,-47,72,1.003,1,1,86,0.5,"loop",-1.66666666666667,3.72,0.0007905706482679,0.220184187397302,6.21642915145485e-06,0,1.2237252074576,-22,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,-5,0,-1,-4,-2,0,-2,0,-0.175278622087133,-0.103359173126615,-0.376801507344459,-0.0104006820119352,-0.0968586387434555,-0.505376344086022,0.321474358974359,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","neutral",0.59,1.183,"3:1","150/150","I:R:L:V:N:Q:F:E:W:T:K:H:Y:D:P:G:M:A:S",-11.9883149074727,0.940801856882948,161.432542873449,-0.0742620706710335,NA,0.975080220739854,-0.657213873251097,0.23001103975255,0.638251318814789,0,1.93160031351699,0.268630815579749,"lineage4","other_mutations_pyrazinamide","MET",0,"SAMN07658719","SRR6046516","lineage4.8","gb","UK","pnca_p.thr87met","A","-","THR","TA87","pnca_complex.pdb"
|
|
"T87M","L4","PZA","T","T87",87,"M",0,"Sensitive","OM","hydrophobic","hydrophobic","neutral","non-polar","polar","non-polar",17.594,-0.692,-0.4,-1.95982,-0.061,-0.37,-47,72,1.003,1,1,86,0.5,"loop",-1.66666666666667,3.72,0.0007905706482679,0.220184187397302,6.21642915145485e-06,0,1.2237252074576,-22,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,-5,0,-1,-4,-2,0,-2,0,-0.175278622087133,-0.103359173126615,-0.376801507344459,-0.0104006820119352,-0.0968586387434555,-0.505376344086022,0.321474358974359,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","neutral",0.59,1.183,"3:1","150/150","I:R:L:V:N:Q:F:E:W:T:K:H:Y:D:P:G:M:A:S",-11.9883149074727,0.940801856882948,161.432542873449,-0.0742620706710335,NA,0.975080220739854,-0.657213873251097,0.23001103975255,0.638251318814789,0,1.93160031351699,0.268630815579749,"lineage4","other_mutations_pyrazinamide","MET",0,"ERR2516168","ERR2516168","lineage4.8","be","Belgium","pnca_p.thr87met","A","-","THR","TA87","pnca_complex.pdb"
|
|
"T87M","L4","PZA","T","T87",87,"M",NA,"Sensitive","OM","hydrophobic","hydrophobic","neutral","non-polar","polar","non-polar",17.594,-0.692,-0.4,-1.95982,-0.061,-0.37,-47,72,1.003,1,1,86,0.5,"loop",-1.66666666666667,3.72,0.0007905706482679,0.220184187397302,6.21642915145485e-06,0,1.2237252074576,-22,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,-5,0,-1,-4,-2,0,-2,0,-0.175278622087133,-0.103359173126615,-0.376801507344459,-0.0104006820119352,-0.0968586387434555,-0.505376344086022,0.321474358974359,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","neutral",0.59,1.183,"3:1","150/150","I:R:L:V:N:Q:F:E:W:T:K:H:Y:D:P:G:M:A:S",-11.9883149074727,0.940801856882948,161.432542873449,-0.0742620706710335,NA,0.975080220739854,-0.657213873251097,0.23001103975255,0.638251318814789,0,1.93160031351699,0.268630815579749,"lineage4","other_mutations_pyrazinamide","MET",0,"ERR3275669","ERR3275669","lineage4.8","nl","Netherlands","pnca_p.thr87met","A","-","THR","TA87","pnca_complex.pdb"
|
|
"T87M","L4","PZA","T","T87",87,"M",0,"Sensitive","OM","hydrophobic","hydrophobic","neutral","non-polar","polar","non-polar",17.594,-0.692,-0.4,-1.95982,-0.061,-0.37,-47,72,1.003,1,1,86,0.5,"loop",-1.66666666666667,3.72,0.0007905706482679,0.220184187397302,6.21642915145485e-06,0,1.2237252074576,-22,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,-5,0,-1,-4,-2,0,-2,0,-0.175278622087133,-0.103359173126615,-0.376801507344459,-0.0104006820119352,-0.0968586387434555,-0.505376344086022,0.321474358974359,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","neutral",0.59,1.183,"3:1","150/150","I:R:L:V:N:Q:F:E:W:T:K:H:Y:D:P:G:M:A:S",-11.9883149074727,0.940801856882948,161.432542873449,-0.0742620706710335,NA,0.975080220739854,-0.657213873251097,0.23001103975255,0.638251318814789,0,1.93160031351699,0.268630815579749,"lineage4","other_mutations_pyrazinamide","MET",0,"ERR046890,SAMEA1019017","ERR046890","lineage4.8","gb","United Kingdom,unknown,UK","pnca_p.thr87met","A","-","THR","TA87","pnca_complex.pdb"
|
|
"T87M","L4","PZA","T","T87",87,"M",NA,"Sensitive","OM","hydrophobic","hydrophobic","neutral","non-polar","polar","non-polar",17.594,-0.692,-0.4,-1.95982,-0.061,-0.37,-47,72,1.003,1,1,86,0.5,"loop",-1.66666666666667,3.72,0.0007905706482679,0.220184187397302,6.21642915145485e-06,0,1.2237252074576,-22,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,-5,0,-1,-4,-2,0,-2,0,-0.175278622087133,-0.103359173126615,-0.376801507344459,-0.0104006820119352,-0.0968586387434555,-0.505376344086022,0.321474358974359,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","neutral",0.59,1.183,"3:1","150/150","I:R:L:V:N:Q:F:E:W:T:K:H:Y:D:P:G:M:A:S",-11.9883149074727,0.940801856882948,161.432542873449,-0.0742620706710335,NA,0.975080220739854,-0.657213873251097,0.23001103975255,0.638251318814789,0,1.93160031351699,0.268630815579749,"lineage4","other_mutations_pyrazinamide","MET",0,"ERR3275805","ERR3275805","lineage4.8","nl","Netherlands","pnca_p.thr87met","A","-","THR","TA87","pnca_complex.pdb"
|
|
"T87M","L4","PZA","T","T87",87,"M",0,"Sensitive","OM","hydrophobic","hydrophobic","neutral","non-polar","polar","non-polar",17.594,-0.692,-0.4,-1.95982,-0.061,-0.37,-47,72,1.003,1,1,86,0.5,"loop",-1.66666666666667,3.72,0.0007905706482679,0.220184187397302,6.21642915145485e-06,0,1.2237252074576,-22,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,-5,0,-1,-4,-2,0,-2,0,-0.175278622087133,-0.103359173126615,-0.376801507344459,-0.0104006820119352,-0.0968586387434555,-0.505376344086022,0.321474358974359,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","neutral",0.59,1.183,"3:1","150/150","I:R:L:V:N:Q:F:E:W:T:K:H:Y:D:P:G:M:A:S",-11.9883149074727,0.940801856882948,161.432542873449,-0.0742620706710335,NA,0.975080220739854,-0.657213873251097,0.23001103975255,0.638251318814789,0,1.93160031351699,0.268630815579749,"lineage4","other_mutations_pyrazinamide","MET",0,"ERR552128,SAMEA2534432","ERR552128","lineage4.8","","","pnca_p.thr87met","A","-","THR","TA87","pnca_complex.pdb"
|
|
"I90S","L4","PZA","I","I90",90,"S",1,"XDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",14.878,0.447,-2.286,4.11572,-2.665,-1.93,38,66,0.151,4,4,24,0.121827411167513,"loop",0.933333333333333,4.88,0.0005030904125341,6.47410526315789,6.47410517670655,6.47281975099898,5.34879705543722,12,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,-1,0,-1,0,0,0,0,0,0.200448430493273,-0.590697674418605,0.149903481231652,-0.454390451832907,-0.505235602094241,0.4,0.0483974358974359,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.147,0.225,"6:4","147/150","P:S:G:A:W:D:E:F:C:I:L:V:N",1.86781040138793,0.0145043045254535,0.764079088633845,2.44452495713176,1.42623754737829,32.8877353882374,0.811179756363585,0.0192724555107824,1.71506294819644,1.09429403734416,44.2397805449942,0.0207365726835135,"lineage4","dr_mutations_pyrazinamide","SER",0,"ERR2041748","ERR2041748","lineage4.2.2.1","rs","Serbia","pnca_p.ile90ser","A","-","ILE","IA90","pnca_complex.pdb"
|
|
"I90S","L2","PZA","I","I90",90,"S",NA,"XDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",14.878,0.447,-2.286,4.11572,-2.665,-1.93,38,66,0.151,4,4,24,0.121827411167513,"loop",0.933333333333333,4.88,0.0005030904125341,6.47410526315789,6.47410517670655,6.47281975099898,5.34879705543722,12,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,-1,0,-1,0,0,0,0,0,0.200448430493273,-0.590697674418605,0.149903481231652,-0.454390451832907,-0.505235602094241,0.4,0.0483974358974359,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.147,0.225,"6:4","147/150","P:S:G:A:W:D:E:F:C:I:L:V:N",1.86781040138793,0.0145043045254535,0.764079088633845,2.44452495713176,1.42623754737829,32.8877353882374,0.811179756363585,0.0192724555107824,1.71506294819644,1.09429403734416,44.2397805449942,0.0207365726835135,"lineage2","dr_mutations_pyrazinamide","SER",0,"SAMN07360953,SRR5837708","SRR5837708","lineage2.1","th","Thailand","pnca_p.ile90ser","A","-","ILE","IA90","pnca_complex.pdb"
|
|
"I90S","L4","PZA","I","I90",90,"S",1,"MDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",14.878,0.447,-2.286,4.11572,-2.665,-1.93,38,66,0.151,4,4,24,0.121827411167513,"loop",0.933333333333333,4.88,0.0005030904125341,6.47410526315789,6.47410517670655,6.47281975099898,5.34879705543722,12,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,-1,0,-1,0,0,0,0,0,0.200448430493273,-0.590697674418605,0.149903481231652,-0.454390451832907,-0.505235602094241,0.4,0.0483974358974359,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.147,0.225,"6:4","147/150","P:S:G:A:W:D:E:F:C:I:L:V:N",1.86781040138793,0.0145043045254535,0.764079088633845,2.44452495713176,1.42623754737829,32.8877353882374,0.811179756363585,0.0192724555107824,1.71506294819644,1.09429403734416,44.2397805449942,0.0207365726835135,"lineage4","dr_mutations_pyrazinamide","SER",0,"ERR2041749","ERR2041749","lineage4.2.2.1","rs","Serbia","pnca_p.ile90ser","A","-","ILE","IA90","pnca_complex.pdb"
|
|
"I90S","L2","PZA","I","I90",90,"S",NA,"XDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",14.878,0.447,-2.286,4.11572,-2.665,-1.93,38,66,0.151,4,4,24,0.121827411167513,"loop",0.933333333333333,4.88,0.0005030904125341,6.47410526315789,6.47410517670655,6.47281975099898,5.34879705543722,12,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,-1,0,-1,0,0,0,0,0,0.200448430493273,-0.590697674418605,0.149903481231652,-0.454390451832907,-0.505235602094241,0.4,0.0483974358974359,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.147,0.225,"6:4","147/150","P:S:G:A:W:D:E:F:C:I:L:V:N",1.86781040138793,0.0145043045254535,0.764079088633845,2.44452495713176,1.42623754737829,32.8877353882374,0.811179756363585,0.0192724555107824,1.71506294819644,1.09429403734416,44.2397805449942,0.0207365726835135,"lineage2","dr_mutations_pyrazinamide","SER",0,"SAMN07236522,SRR5709887","SRR5709887","lineage2.1","th","Thailand","pnca_p.ile90ser","A","-","ILE","IA90","pnca_complex.pdb"
|
|
"I90S","L2","PZA","I","I90",90,"S",NA,"XDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",14.878,0.447,-2.286,4.11572,-2.665,-1.93,38,66,0.151,4,4,24,0.121827411167513,"loop",0.933333333333333,4.88,0.0005030904125341,6.47410526315789,6.47410517670655,6.47281975099898,5.34879705543722,12,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,-1,0,-1,0,0,0,0,0,0.200448430493273,-0.590697674418605,0.149903481231652,-0.454390451832907,-0.505235602094241,0.4,0.0483974358974359,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.147,0.225,"6:4","147/150","P:S:G:A:W:D:E:F:C:I:L:V:N",1.86781040138793,0.0145043045254535,0.764079088633845,2.44452495713176,1.42623754737829,32.8877353882374,0.811179756363585,0.0192724555107824,1.71506294819644,1.09429403734416,44.2397805449942,0.0207365726835135,"lineage2","dr_mutations_pyrazinamide","SER",0,"SRR5709764,SAMN07236516","SRR5709764","lineage2.1","th","Thailand","pnca_p.ile90ser","A","-","ILE","IA90","pnca_complex.pdb"
|
|
"I90S","L2","PZA","I","I90",90,"S",NA,"XDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",14.878,0.447,-2.286,4.11572,-2.665,-1.93,38,66,0.151,4,4,24,0.121827411167513,"loop",0.933333333333333,4.88,0.0005030904125341,6.47410526315789,6.47410517670655,6.47281975099898,5.34879705543722,12,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,-1,0,-1,0,0,0,0,0,0.200448430493273,-0.590697674418605,0.149903481231652,-0.454390451832907,-0.505235602094241,0.4,0.0483974358974359,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.147,0.225,"6:4","147/150","P:S:G:A:W:D:E:F:C:I:L:V:N",1.86781040138793,0.0145043045254535,0.764079088633845,2.44452495713176,1.42623754737829,32.8877353882374,0.811179756363585,0.0192724555107824,1.71506294819644,1.09429403734416,44.2397805449942,0.0207365726835135,"lineage2","dr_mutations_pyrazinamide","SER",0,"SRR5709798,SAMN07236261","SRR5709798","lineage2.1","th","Thailand","pnca_p.ile90ser","A","-","ILE","IA90","pnca_complex.pdb"
|
|
"I90S","L2","PZA","I","I90",90,"S",NA,"XDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",14.878,0.447,-2.286,4.11572,-2.665,-1.93,38,66,0.151,4,4,24,0.121827411167513,"loop",0.933333333333333,4.88,0.0005030904125341,6.47410526315789,6.47410517670655,6.47281975099898,5.34879705543722,12,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,-1,0,-1,0,0,0,0,0,0.200448430493273,-0.590697674418605,0.149903481231652,-0.454390451832907,-0.505235602094241,0.4,0.0483974358974359,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.147,0.225,"6:4","147/150","P:S:G:A:W:D:E:F:C:I:L:V:N",1.86781040138793,0.0145043045254535,0.764079088633845,2.44452495713176,1.42623754737829,32.8877353882374,0.811179756363585,0.0192724555107824,1.71506294819644,1.09429403734416,44.2397805449942,0.0207365726835135,"lineage2","dr_mutations_pyrazinamide","SER",0,"SAMN07236515,SRR5709934","SRR5709934","lineage2.1","th","Thailand","pnca_p.ile90ser","A","-","ILE","IA90","pnca_complex.pdb"
|
|
"I90S","L2","PZA","I","I90",90,"S",NA,"XDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",14.878,0.447,-2.286,4.11572,-2.665,-1.93,38,66,0.151,4,4,24,0.121827411167513,"loop",0.933333333333333,4.88,0.0005030904125341,6.47410526315789,6.47410517670655,6.47281975099898,5.34879705543722,12,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,-1,0,-1,0,0,0,0,0,0.200448430493273,-0.590697674418605,0.149903481231652,-0.454390451832907,-0.505235602094241,0.4,0.0483974358974359,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.147,0.225,"6:4","147/150","P:S:G:A:W:D:E:F:C:I:L:V:N",1.86781040138793,0.0145043045254535,0.764079088633845,2.44452495713176,1.42623754737829,32.8877353882374,0.811179756363585,0.0192724555107824,1.71506294819644,1.09429403734416,44.2397805449942,0.0207365726835135,"lineage2","dr_mutations_pyrazinamide","SER",0,"SRR5710027,SAMN07236539","SRR5710027","lineage2.1","th","Thailand","pnca_p.ile90ser","A","-","ILE","IA90","pnca_complex.pdb"
|
|
"I90S","L2","PZA","I","I90",90,"S",NA,"Other","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",14.878,0.447,-2.286,4.11572,-2.665,-1.93,38,66,0.151,4,4,24,0.121827411167513,"loop",0.933333333333333,4.88,0.0005030904125341,6.47410526315789,6.47410517670655,6.47281975099898,5.34879705543722,12,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,-1,0,-1,0,0,0,0,0,0.200448430493273,-0.590697674418605,0.149903481231652,-0.454390451832907,-0.505235602094241,0.4,0.0483974358974359,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.147,0.225,"6:4","147/150","P:S:G:A:W:D:E:F:C:I:L:V:N",1.86781040138793,0.0145043045254535,0.764079088633845,2.44452495713176,1.42623754737829,32.8877353882374,0.811179756363585,0.0192724555107824,1.71506294819644,1.09429403734416,44.2397805449942,0.0207365726835135,"lineage2","dr_mutations_pyrazinamide","SER",0,"SRR1710062","SRR1710062","lineage2.1","cn","","pnca_p.ile90ser","A","-","ILE","IA90","pnca_complex.pdb"
|
|
"I90S","L4","PZA","I","I90",90,"S",1,"MDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",14.878,0.447,-2.286,4.11572,-2.665,-1.93,38,66,0.151,4,4,24,0.121827411167513,"loop",0.933333333333333,4.88,0.0005030904125341,6.47410526315789,6.47410517670655,6.47281975099898,5.34879705543722,12,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,-1,0,-1,0,0,0,0,0,0.200448430493273,-0.590697674418605,0.149903481231652,-0.454390451832907,-0.505235602094241,0.4,0.0483974358974359,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.147,0.225,"6:4","147/150","P:S:G:A:W:D:E:F:C:I:L:V:N",1.86781040138793,0.0145043045254535,0.764079088633845,2.44452495713176,1.42623754737829,32.8877353882374,0.811179756363585,0.0192724555107824,1.71506294819644,1.09429403734416,44.2397805449942,0.0207365726835135,"lineage4","dr_mutations_pyrazinamide","SER",0,"ERR2041759","ERR2041759","lineage4.2.2.1","rs","Serbia","pnca_p.ile90ser","A","-","ILE","IA90","pnca_complex.pdb"
|
|
"I90S","L4","PZA","I","I90",90,"S",1,"XDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",14.878,0.447,-2.286,4.11572,-2.665,-1.93,38,66,0.151,4,4,24,0.121827411167513,"loop",0.933333333333333,4.88,0.0005030904125341,6.47410526315789,6.47410517670655,6.47281975099898,5.34879705543722,12,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,-1,0,-1,0,0,0,0,0,0.200448430493273,-0.590697674418605,0.149903481231652,-0.454390451832907,-0.505235602094241,0.4,0.0483974358974359,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.147,0.225,"6:4","147/150","P:S:G:A:W:D:E:F:C:I:L:V:N",1.86781040138793,0.0145043045254535,0.764079088633845,2.44452495713176,1.42623754737829,32.8877353882374,0.811179756363585,0.0192724555107824,1.71506294819644,1.09429403734416,44.2397805449942,0.0207365726835135,"lineage4","dr_mutations_pyrazinamide","SER",0,"ERR2199914","ERR2199914","lineage4.2.2.1","rs","Serbia","pnca_p.ile90ser","A","-","ILE","IA90","pnca_complex.pdb"
|
|
"I90S","L4","PZA","I","I90",90,"S",0,"Pre-XDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",14.878,0.447,-2.286,4.11572,-2.665,-1.93,38,66,0.151,4,4,24,0.121827411167513,"loop",0.933333333333333,4.88,0.0005030904125341,6.47410526315789,6.47410517670655,6.47281975099898,5.34879705543722,12,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,-1,0,-1,0,0,0,0,0,0.200448430493273,-0.590697674418605,0.149903481231652,-0.454390451832907,-0.505235602094241,0.4,0.0483974358974359,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.147,0.225,"6:4","147/150","P:S:G:A:W:D:E:F:C:I:L:V:N",1.86781040138793,0.0145043045254535,0.764079088633845,2.44452495713176,1.42623754737829,32.8877353882374,0.811179756363585,0.0192724555107824,1.71506294819644,1.09429403734416,44.2397805449942,0.0207365726835135,"lineage4","dr_mutations_pyrazinamide","SER",0,"ERR2041766","ERR2041766","lineage4.2.2.1","rs","Serbia","pnca_p.ile90ser","A","-","ILE","IA90","pnca_complex.pdb"
|
|
"I90S","L4","PZA","I","I90",90,"S",0,"XDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",14.878,0.447,-2.286,4.11572,-2.665,-1.93,38,66,0.151,4,4,24,0.121827411167513,"loop",0.933333333333333,4.88,0.0005030904125341,6.47410526315789,6.47410517670655,6.47281975099898,5.34879705543722,12,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,-1,0,-1,0,0,0,0,0,0.200448430493273,-0.590697674418605,0.149903481231652,-0.454390451832907,-0.505235602094241,0.4,0.0483974358974359,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.147,0.225,"6:4","147/150","P:S:G:A:W:D:E:F:C:I:L:V:N",1.86781040138793,0.0145043045254535,0.764079088633845,2.44452495713176,1.42623754737829,32.8877353882374,0.811179756363585,0.0192724555107824,1.71506294819644,1.09429403734416,44.2397805449942,0.0207365726835135,"lineage4","dr_mutations_pyrazinamide","SER",0,"ERR2041718","ERR2041718","lineage4.2.2.1","rs","Serbia","pnca_p.ile90ser","A","-","ILE","IA90","pnca_complex.pdb"
|
|
"I90S","L2","PZA","I","I90",90,"S",NA,"XDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",14.878,0.447,-2.286,4.11572,-2.665,-1.93,38,66,0.151,4,4,24,0.121827411167513,"loop",0.933333333333333,4.88,0.0005030904125341,6.47410526315789,6.47410517670655,6.47281975099898,5.34879705543722,12,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,-1,0,-1,0,0,0,0,0,0.200448430493273,-0.590697674418605,0.149903481231652,-0.454390451832907,-0.505235602094241,0.4,0.0483974358974359,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.147,0.225,"6:4","147/150","P:S:G:A:W:D:E:F:C:I:L:V:N",1.86781040138793,0.0145043045254535,0.764079088633845,2.44452495713176,1.42623754737829,32.8877353882374,0.811179756363585,0.0192724555107824,1.71506294819644,1.09429403734416,44.2397805449942,0.0207365726835135,"lineage2","dr_mutations_pyrazinamide","SER",0,"SRR5709899,SAMN07236526","SRR5709899","lineage2.1","th","Thailand","pnca_p.ile90ser","A","-","ILE","IA90","pnca_complex.pdb"
|
|
"I90S","L4","PZA","I","I90",90,"S",0,"XDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",14.878,0.447,-2.286,4.11572,-2.665,-1.93,38,66,0.151,4,4,24,0.121827411167513,"loop",0.933333333333333,4.88,0.0005030904125341,6.47410526315789,6.47410517670655,6.47281975099898,5.34879705543722,12,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,-1,0,-1,0,0,0,0,0,0.200448430493273,-0.590697674418605,0.149903481231652,-0.454390451832907,-0.505235602094241,0.4,0.0483974358974359,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.147,0.225,"6:4","147/150","P:S:G:A:W:D:E:F:C:I:L:V:N",1.86781040138793,0.0145043045254535,0.764079088633845,2.44452495713176,1.42623754737829,32.8877353882374,0.811179756363585,0.0192724555107824,1.71506294819644,1.09429403734416,44.2397805449942,0.0207365726835135,"lineage4","dr_mutations_pyrazinamide","SER",0,"ERR2200093","ERR2200093","lineage4.2.2.1","rs","Serbia","pnca_p.ile90ser","A","-","ILE","IA90","pnca_complex.pdb"
|
|
"I90S","L2","PZA","I","I90",90,"S",NA,"XDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",14.878,0.447,-2.286,4.11572,-2.665,-1.93,38,66,0.151,4,4,24,0.121827411167513,"loop",0.933333333333333,4.88,0.0005030904125341,6.47410526315789,6.47410517670655,6.47281975099898,5.34879705543722,12,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,-1,0,-1,0,0,0,0,0,0.200448430493273,-0.590697674418605,0.149903481231652,-0.454390451832907,-0.505235602094241,0.4,0.0483974358974359,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.147,0.225,"6:4","147/150","P:S:G:A:W:D:E:F:C:I:L:V:N",1.86781040138793,0.0145043045254535,0.764079088633845,2.44452495713176,1.42623754737829,32.8877353882374,0.811179756363585,0.0192724555107824,1.71506294819644,1.09429403734416,44.2397805449942,0.0207365726835135,"lineage2","dr_mutations_pyrazinamide","SER",0,"SRR5709872,SAMN07236537","SRR5709872","lineage2.1","th","Thailand","pnca_p.ile90ser","A","-","ILE","IA90","pnca_complex.pdb"
|
|
"I90S","L2","PZA","I","I90",90,"S",NA,"XDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",14.878,0.447,-2.286,4.11572,-2.665,-1.93,38,66,0.151,4,4,24,0.121827411167513,"loop",0.933333333333333,4.88,0.0005030904125341,6.47410526315789,6.47410517670655,6.47281975099898,5.34879705543722,12,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,-1,0,-1,0,0,0,0,0,0.200448430493273,-0.590697674418605,0.149903481231652,-0.454390451832907,-0.505235602094241,0.4,0.0483974358974359,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.147,0.225,"6:4","147/150","P:S:G:A:W:D:E:F:C:I:L:V:N",1.86781040138793,0.0145043045254535,0.764079088633845,2.44452495713176,1.42623754737829,32.8877353882374,0.811179756363585,0.0192724555107824,1.71506294819644,1.09429403734416,44.2397805449942,0.0207365726835135,"lineage2","dr_mutations_pyrazinamide","SER",0,"SRR5709762,SAMN07236535","SRR5709762","lineage2.1","th","Thailand","pnca_p.ile90ser","A","-","ILE","IA90","pnca_complex.pdb"
|
|
"I90S","L2","PZA","I","I90",90,"S",NA,"MDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",14.878,0.447,-2.286,4.11572,-2.665,-1.93,38,66,0.151,4,4,24,0.121827411167513,"loop",0.933333333333333,4.88,0.0005030904125341,6.47410526315789,6.47410517670655,6.47281975099898,5.34879705543722,12,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,-1,0,-1,0,0,0,0,0,0.200448430493273,-0.590697674418605,0.149903481231652,-0.454390451832907,-0.505235602094241,0.4,0.0483974358974359,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.147,0.225,"6:4","147/150","P:S:G:A:W:D:E:F:C:I:L:V:N",1.86781040138793,0.0145043045254535,0.764079088633845,2.44452495713176,1.42623754737829,32.8877353882374,0.811179756363585,0.0192724555107824,1.71506294819644,1.09429403734416,44.2397805449942,0.0207365726835135,"lineage2","dr_mutations_pyrazinamide","SER",0,"ERR775794","ERR775794","lineage2.1","th","Thailand","pnca_p.ile90ser","A","-","ILE","IA90","pnca_complex.pdb"
|
|
"I90T","L4","PZA","I","I90",90,"T",1,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",14.878,0.462,-1.983,2.28269,-2.457,-1.55,42,71,0.151,4,4,24,0.121827411167513,"loop",0.933333333333333,4.88,0.0002874802357337,14.5631313131313,14.5630810302278,14.5631012253236,5.81873994206135,10,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,-1,0,-1,0,2,0,0,2,0.207174887892377,-0.512403100775194,0.0831405386111496,-0.418925831202046,-0.405759162303665,0.442105263157895,0.0483974358974359,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.147,0.225,"6:4","147/150","P:S:G:A:W:D:E:F:C:I:L:V:N",2.67848962960141,0.0202679102821363,1.15384949648317,2.3213509541454,1.8636331786073,294.488177945833,1.16325476548539,0.0174140488202037,1.75910024233227,1.16837785201846,760.989759542733,0.0158563003544608,"lineage4","other_mutations_pyrazinamide","THR",0,"ERR2516485","ERR2516485","lineage4.3.4.2;lineage4.1.2.1","pe","Peru","pnca_p.ile90thr","A","-","ILE","IA90","pnca_complex.pdb"
|
|
"I90T","L4","PZA","I","I90",90,"T",1,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",14.878,0.462,-1.983,2.28269,-2.457,-1.55,42,71,0.151,4,4,24,0.121827411167513,"loop",0.933333333333333,4.88,0.0002874802357337,14.5631313131313,14.5630810302278,14.5631012253236,5.81873994206135,10,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,-1,0,-1,0,2,0,0,2,0.207174887892377,-0.512403100775194,0.0831405386111496,-0.418925831202046,-0.405759162303665,0.442105263157895,0.0483974358974359,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.147,0.225,"6:4","147/150","P:S:G:A:W:D:E:F:C:I:L:V:N",2.67848962960141,0.0202679102821363,1.15384949648317,2.3213509541454,1.8636331786073,294.488177945833,1.16325476548539,0.0174140488202037,1.75910024233227,1.16837785201846,760.989759542733,0.0158563003544608,"lineage4","other_mutations_pyrazinamide","THR",0,"ERR2516734","ERR2516734","lineage4.3.4.2","pe","Peru","pnca_p.ile90thr","A","-","ILE","IA90","pnca_complex.pdb"
|
|
"I90T","L3","PZA","I","I90",90,"T",0,"MDR","OM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",14.878,0.462,-1.983,2.28269,-2.457,-1.55,42,71,0.151,4,4,24,0.121827411167513,"loop",0.933333333333333,4.88,0.0002874802357337,14.5631313131313,14.5630810302278,14.5631012253236,5.81873994206135,10,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,-1,0,-1,0,2,0,0,2,0.207174887892377,-0.512403100775194,0.0831405386111496,-0.418925831202046,-0.405759162303665,0.442105263157895,0.0483974358974359,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.147,0.225,"6:4","147/150","P:S:G:A:W:D:E:F:C:I:L:V:N",2.67848962960141,0.0202679102821363,1.15384949648317,2.3213509541454,1.8636331786073,294.488177945833,1.16325476548539,0.0174140488202037,1.75910024233227,1.16837785201846,760.989759542733,0.0158563003544608,"lineage3","other_mutations_pyrazinamide","THR",0,"ERR040126","ERR040126","lineage3.1.1","ug","Uganda","pnca_p.ile90thr","A","-","ILE","IA90","pnca_complex.pdb"
|
|
"I90T","L4","PZA","I","I90",90,"T",1,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",14.878,0.462,-1.983,2.28269,-2.457,-1.55,42,71,0.151,4,4,24,0.121827411167513,"loop",0.933333333333333,4.88,0.0002874802357337,14.5631313131313,14.5630810302278,14.5631012253236,5.81873994206135,10,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,-1,0,-1,0,2,0,0,2,0.207174887892377,-0.512403100775194,0.0831405386111496,-0.418925831202046,-0.405759162303665,0.442105263157895,0.0483974358974359,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.147,0.225,"6:4","147/150","P:S:G:A:W:D:E:F:C:I:L:V:N",2.67848962960141,0.0202679102821363,1.15384949648317,2.3213509541454,1.8636331786073,294.488177945833,1.16325476548539,0.0174140488202037,1.75910024233227,1.16837785201846,760.989759542733,0.0158563003544608,"lineage4","other_mutations_pyrazinamide","THR",0,"ERR2516630","ERR2516630","lineage4.3.4.2","pe","Peru","pnca_p.ile90thr","A","-","ILE","IA90","pnca_complex.pdb"
|
|
"A92G","L1","PZA","A","A92",92,"G",NA,"Sensitive","OM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",15.57,-1.692,-0.574,1.40665,-1.618,-0.96,12,59,0.318,4,4,11,0.0852713178294573,"strand",0.833333333333333,4.62,NA,NA,NA,NA,NA,6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,2,0,0,0,3,12,-0.428571428571428,-0.148320413436692,0.0512332549042461,-0.275873827791986,-0.25130890052356,0.126315789473684,0.101923076923077,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.083,0.389,"5:4","150/150","I:R:V:L:Q:E:F:W:T:K:Y:H:P:M:S:A:G",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage1","other_mutations_pyrazinamide","GLY",0,"ERR2679251","ERR2679251","lineage1.1.1","","","pnca_p.ala92gly","A","E","ALA","AA92","pnca_complex.pdb"
|
|
"A92P","L2","PZA","A","A92",92,"P",0,"MDR","OM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",15.57,-1.787,0.14,0.275359,-2.918,0.76,9,53,0.318,4,4,11,0.0852713178294573,"strand",0.833333333333333,4.62,7.18700589334483e-05,2.42412778478352,0.0001249735077034,0,1.03410070803344e-29,0,2,0,0,2,0,0,0,0,0,0,0,0,0,0,0,0,-6,2,-2,-6,2,0,0,-3,-0.452634245187437,0.119047619047619,0.0100291741635647,-0.497527706734868,0.426966292134831,0.0947368421052632,0.101923076923077,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",0.083,0.389,"5:4","150/150","I:R:V:L:Q:E:F:W:T:K:Y:H:P:M:S:A:G",-8.98740878149641,0.940032862253633,119.46804443549,-0.0752285585987756,NA,4692673.5108108,0.384555509373631,1,0,0,188.544222231268,0.999999999999997,"lineage2","other_mutations_pyrazinamide","PRO",0,"MDR_18428","SRR6824520","lineage2.2.1","cn","China: Taojiang County, Yiyang City, Hunan Province","pnca_p.ala92pro","A","E","ALA","AA92","pnca_complex.pdb"
|
|
"A92V","L1","PZA","A","A92",92,"V",NA,"Sensitive","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",15.57,-1.782,0.941,-1.35941,-0.312,0.55,-40,66,0.318,4,4,11,0.0852713178294573,"strand",0.833333333333333,4.62,NA,NA,NA,NA,NA,0,2,0,0,2,0,0,0,0,0,0,0,0,0,0,0,0,-6,0,0,-6,-4,0,-2,-3,-0.451367781155015,0.800170068027211,-0.261364685072676,-0.0531969309462916,0.308988764044944,-0.43010752688172,0.101923076923077,"Destabilising","Stabilising","Stabilising","Destabilising","Stabilising","neutral",0.083,0.389,"5:4","150/150","I:R:V:L:Q:E:F:W:T:K:Y:H:P:M:S:A:G",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage1","other_mutations_pyrazinamide","VAL",0,"SRR5073850","SRR5073850","lineage1.1.1","vn","Vietnam","pnca_p.ala92val","A","E","ALA","AA92","pnca_complex.pdb"
|
|
"V93G","L4","PZA","V","V93",93,"G",NA,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",13.206,-0.958,-2.333,3.06107,-2.536,-2.72,41,71,-0.095,5,5,27,0.155172413793103,"strand",2.93333333333333,4.76,NA,NA,NA,NA,NA,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,2,0,0,1,4,0,13,15,-0.242654508611955,-0.602842377260982,0.111490832538116,-0.432395566922421,-0.712041884816754,0.431578947368421,-0.0782537067545305,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","150/150","W:T:A:S:K:I:C:R:L:V:Q:H:Y:E",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage4","other_mutations_pyrazinamide","GLY",0,"SAMN02584678","SRR1166143_SRR1169099","lineage4.2.1","md","Moldova","pnca_p.val93gly","A","E","VAL","VA93","pnca_complex.pdb"
|
|
"V93G","L4","PZA","V","V93",93,"G",NA,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",13.206,-0.958,-2.333,3.06107,-2.536,-2.72,41,71,-0.095,5,5,27,0.155172413793103,"strand",2.93333333333333,4.76,NA,NA,NA,NA,NA,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,2,0,0,1,4,0,13,15,-0.242654508611955,-0.602842377260982,0.111490832538116,-0.432395566922421,-0.712041884816754,0.431578947368421,-0.0782537067545305,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","150/150","W:T:A:S:K:I:C:R:L:V:Q:H:Y:E",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage4","other_mutations_pyrazinamide","GLY",0,"SAMN02584666","SRR1169229_SRR1166103","lineage4.2.1","md","Moldova","pnca_p.val93gly","A","E","VAL","VA93","pnca_complex.pdb"
|
|
"V93L","L4","PZA","V","V93",93,"L",NA,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",13.206,-1.213,-0.015,-1.8226,-0.026,-0.52,-1,53,-0.095,5,5,27,0.155172413793103,"strand",2.93333333333333,4.76,NA,NA,NA,NA,NA,-14,0,0,0,0,0,0,0,0,-2,0,0,-2,0,0,0,0,-8,0,-5,-4,0,0,2,-2,-0.307244174265451,-0.003875968992248,-0.350419134045989,-0.00443307757885763,-0.136125654450262,-0.010752688172043,-0.0782537067545305,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","neutral",-0.332,-0.038,"6:5","150/150","W:T:A:S:K:I:C:R:L:V:Q:H:Y:E",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage4","other_mutations_pyrazinamide","LEU",0,"ERR2516559","ERR2516559","lineage4.1.2.1","pe","Peru","pnca_p.val93leu","A","E","VAL","VA93","pnca_complex.pdb"
|
|
"V93L","L4","PZA","V","V93",93,"L",NA,"MDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",13.206,-1.213,-0.015,-1.8226,-0.026,-0.52,-1,53,-0.095,5,5,27,0.155172413793103,"strand",2.93333333333333,4.76,NA,NA,NA,NA,NA,-14,0,0,0,0,0,0,0,0,-2,0,0,-2,0,0,0,0,-8,0,-5,-4,0,0,2,-2,-0.307244174265451,-0.003875968992248,-0.350419134045989,-0.00443307757885763,-0.136125654450262,-0.010752688172043,-0.0782537067545305,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","neutral",-0.332,-0.038,"6:5","150/150","W:T:A:S:K:I:C:R:L:V:Q:H:Y:E",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage4","other_mutations_pyrazinamide","LEU",0,"ERR552431","ERR552431","lineage4.1","cg","Congo","pnca_p.val93leu","A","E","VAL","VA93","pnca_complex.pdb"
|
|
"F94C","L4","PZA","F","F94",94,"C",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",10.621,-1.615,-1.595,4.52813,-3.58,-1.42,49,71,-0.13,5,5,0,0,"strand",1.9,7.59,0.0002874802357337,14.5631313131313,14.5630810302278,14.5631012253236,5.81873994206135,28,4,0,0,4,0,0,0,0,0,0,-2,0,0,0,0,0,2,0,0,2,8,0,8,6,-0.409067882472138,-0.412144702842377,0.164924351138921,-0.610400682011935,-0.371727748691099,0.515789473684211,-0.107084019769357,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","150/150","A:F:Q:V:L:I",2.67848962960141,0.0202679102821361,1.15384949648317,2.3213509541454,1.86363317860726,294.488177945833,1.16325476548539,0.0174140488202037,1.75910024233227,1.16837785201846,760.989759542733,0.0158563003544608,"lineage4","dr_mutations_pyrazinamide","CYS",0,"ERR1035329","ERR1035329","lineage4.3.3","br","Brazil","pnca_p.phe94cys","A","E","PHE","FA94","pnca_complex.pdb"
|
|
"F94C","L4","PZA","F","F94",94,"C",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",10.621,-1.615,-1.595,4.52813,-3.58,-1.42,49,71,-0.13,5,5,0,0,"strand",1.9,7.59,0.0002874802357337,14.5631313131313,14.5630810302278,14.5631012253236,5.81873994206135,28,4,0,0,4,0,0,0,0,0,0,-2,0,0,0,0,0,2,0,0,2,8,0,8,6,-0.409067882472138,-0.412144702842377,0.164924351138921,-0.610400682011935,-0.371727748691099,0.515789473684211,-0.107084019769357,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","150/150","A:F:Q:V:L:I",2.67848962960141,0.0202679102821361,1.15384949648317,2.3213509541454,1.86363317860726,294.488177945833,1.16325476548539,0.0174140488202037,1.75910024233227,1.16837785201846,760.989759542733,0.0158563003544608,"lineage4","dr_mutations_pyrazinamide","CYS",0,"SAMN02414971","SRR1163223_SRR1165532_SRR1162861_SRR1165590","lineage4.2.2","se","Sweden","pnca_p.phe94cys","A","E","PHE","FA94","pnca_complex.pdb"
|
|
"F94C","L4","PZA","F","F94",94,"C",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",10.621,-1.615,-1.595,4.52813,-3.58,-1.42,49,71,-0.13,5,5,0,0,"strand",1.9,7.59,0.0002874802357337,14.5631313131313,14.5630810302278,14.5631012253236,5.81873994206135,28,4,0,0,4,0,0,0,0,0,0,-2,0,0,0,0,0,2,0,0,2,8,0,8,6,-0.409067882472138,-0.412144702842377,0.164924351138921,-0.610400682011935,-0.371727748691099,0.515789473684211,-0.107084019769357,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","150/150","A:F:Q:V:L:I",2.67848962960141,0.0202679102821361,1.15384949648317,2.3213509541454,1.86363317860726,294.488177945833,1.16325476548539,0.0174140488202037,1.75910024233227,1.16837785201846,760.989759542733,0.0158563003544608,"lineage4","dr_mutations_pyrazinamide","CYS",0,"SAMN02414974","SRR1167128_SRR1166933_SRR1165450_SRR1162893","lineage4.2.2","se","Sweden","pnca_p.phe94cys","A","E","PHE","FA94","pnca_complex.pdb"
|
|
"F94C","L4","PZA","F","F94",94,"C",1,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",10.621,-1.615,-1.595,4.52813,-3.58,-1.42,49,71,-0.13,5,5,0,0,"strand",1.9,7.59,0.0002874802357337,14.5631313131313,14.5630810302278,14.5631012253236,5.81873994206135,28,4,0,0,4,0,0,0,0,0,0,-2,0,0,0,0,0,2,0,0,2,8,0,8,6,-0.409067882472138,-0.412144702842377,0.164924351138921,-0.610400682011935,-0.371727748691099,0.515789473684211,-0.107084019769357,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","150/150","A:F:Q:V:L:I",2.67848962960141,0.0202679102821361,1.15384949648317,2.3213509541454,1.86363317860726,294.488177945833,1.16325476548539,0.0174140488202037,1.75910024233227,1.16837785201846,760.989759542733,0.0158563003544608,"lineage4","dr_mutations_pyrazinamide","CYS",0,"ERS2592747","ERR2677397","lineage4.2.2","de","Germany","pnca_p.phe94cys","A","E","PHE","FA94","pnca_complex.pdb"
|
|
"F94C","L2","PZA","F","F94",94,"C",0,"XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",10.621,-1.615,-1.595,4.52813,-3.58,-1.42,49,71,-0.13,5,5,0,0,"strand",1.9,7.59,0.0002874802357337,14.5631313131313,14.5630810302278,14.5631012253236,5.81873994206135,28,4,0,0,4,0,0,0,0,0,0,-2,0,0,0,0,0,2,0,0,2,8,0,8,6,-0.409067882472138,-0.412144702842377,0.164924351138921,-0.610400682011935,-0.371727748691099,0.515789473684211,-0.107084019769357,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","150/150","A:F:Q:V:L:I",2.67848962960141,0.0202679102821361,1.15384949648317,2.3213509541454,1.86363317860726,294.488177945833,1.16325476548539,0.0174140488202037,1.75910024233227,1.16837785201846,760.989759542733,0.0158563003544608,"lineage2","dr_mutations_pyrazinamide","CYS",0,"ERR133890,0591T-sc-2012-02-09T18:56:27Z-1355223","ERR133890","lineage2.2.1","ru","Russia,Samara","pnca_p.phe94cys","A","E","PHE","FA94","pnca_complex.pdb"
|
|
"F94C","L4","PZA","F","F94",94,"C",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",10.621,-1.615,-1.595,4.52813,-3.58,-1.42,49,71,-0.13,5,5,0,0,"strand",1.9,7.59,0.0002874802357337,14.5631313131313,14.5630810302278,14.5631012253236,5.81873994206135,28,4,0,0,4,0,0,0,0,0,0,-2,0,0,0,0,0,2,0,0,2,8,0,8,6,-0.409067882472138,-0.412144702842377,0.164924351138921,-0.610400682011935,-0.371727748691099,0.515789473684211,-0.107084019769357,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","150/150","A:F:Q:V:L:I",2.67848962960141,0.0202679102821361,1.15384949648317,2.3213509541454,1.86363317860726,294.488177945833,1.16325476548539,0.0174140488202037,1.75910024233227,1.16837785201846,760.989759542733,0.0158563003544608,"lineage4","dr_mutations_pyrazinamide","CYS",0,"SAMN02414957","SRR1163168_SRR1162852_SRR1165554_SRR1165530","lineage4.2.2","se","Sweden","pnca_p.phe94cys","A","E","PHE","FA94","pnca_complex.pdb"
|
|
"F94C","L4","PZA","F","F94",94,"C",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",10.621,-1.615,-1.595,4.52813,-3.58,-1.42,49,71,-0.13,5,5,0,0,"strand",1.9,7.59,0.0002874802357337,14.5631313131313,14.5630810302278,14.5631012253236,5.81873994206135,28,4,0,0,4,0,0,0,0,0,0,-2,0,0,0,0,0,2,0,0,2,8,0,8,6,-0.409067882472138,-0.412144702842377,0.164924351138921,-0.610400682011935,-0.371727748691099,0.515789473684211,-0.107084019769357,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","150/150","A:F:Q:V:L:I",2.67848962960141,0.0202679102821361,1.15384949648317,2.3213509541454,1.86363317860726,294.488177945833,1.16325476548539,0.0174140488202037,1.75910024233227,1.16837785201846,760.989759542733,0.0158563003544608,"lineage4","dr_mutations_pyrazinamide","CYS",0,"SAMN02414961","SRR1162847_SRR1167124_SRR1166822_SRR1165431","lineage4.2.2","se","Sweden","pnca_p.phe94cys","A","E","PHE","FA94","pnca_complex.pdb"
|
|
"F94C","L4","PZA","F","F94",94,"C",1,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",10.621,-1.615,-1.595,4.52813,-3.58,-1.42,49,71,-0.13,5,5,0,0,"strand",1.9,7.59,0.0002874802357337,14.5631313131313,14.5630810302278,14.5631012253236,5.81873994206135,28,4,0,0,4,0,0,0,0,0,0,-2,0,0,0,0,0,2,0,0,2,8,0,8,6,-0.409067882472138,-0.412144702842377,0.164924351138921,-0.610400682011935,-0.371727748691099,0.515789473684211,-0.107084019769357,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","150/150","A:F:Q:V:L:I",2.67848962960141,0.0202679102821361,1.15384949648317,2.3213509541454,1.86363317860726,294.488177945833,1.16325476548539,0.0174140488202037,1.75910024233227,1.16837785201846,760.989759542733,0.0158563003544608,"lineage4","dr_mutations_pyrazinamide","CYS",0,"ERR2041721","ERR2041721","lineage4.8","rs","Serbia","pnca_p.phe94cys","A","E","PHE","FA94","pnca_complex.pdb"
|
|
"F94C","L4","PZA","F","F94",94,"C",1,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",10.621,-1.615,-1.595,4.52813,-3.58,-1.42,49,71,-0.13,5,5,0,0,"strand",1.9,7.59,0.0002874802357337,14.5631313131313,14.5630810302278,14.5631012253236,5.81873994206135,28,4,0,0,4,0,0,0,0,0,0,-2,0,0,0,0,0,2,0,0,2,8,0,8,6,-0.409067882472138,-0.412144702842377,0.164924351138921,-0.610400682011935,-0.371727748691099,0.515789473684211,-0.107084019769357,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","150/150","A:F:Q:V:L:I",2.67848962960141,0.0202679102821361,1.15384949648317,2.3213509541454,1.86363317860726,294.488177945833,1.16325476548539,0.0174140488202037,1.75910024233227,1.16837785201846,760.989759542733,0.0158563003544608,"lineage4","dr_mutations_pyrazinamide","CYS",0,"ERR2041714","ERR2041714","lineage4.8","rs","Serbia","pnca_p.phe94cys","A","E","PHE","FA94","pnca_complex.pdb"
|
|
"F94L","L4","PZA","F","F94",94,"L",1,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",10.621,-1.712,-1.582,1.1796,-2.563,-1.99,24,63,-0.13,5,5,0,0,"strand",1.9,7.59,0.0005030904125341,6.47410526315789,6.47410517670654,6.47281975099898,5.34879705543722,16,4,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,-3,0,-1,-3,2,0,6,2,-0.433637284701115,-0.408785529715762,0.0429635996765711,-0.436999147485081,-0.520942408376963,0.252631578947368,-0.107084019769357,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","150/150","A:F:Q:V:L:I",1.86781040138793,0.0145043045254536,0.764079088633845,2.44452495713176,1.42623754737775,32.8877353882363,0.811179756363585,0.0192724555107824,1.71506294819644,1.09429403734416,44.2397805449942,0.0207365726835135,"lineage4","dr_mutations_pyrazinamide","LEU",0,"ERR2516686","ERR2516686","lineage4.1.1","pe","Peru","pnca_p.phe94leu","A","E","PHE","FA94","pnca_complex.pdb"
|
|
"F94L","L2","PZA","F","F94",94,"L",0,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",10.621,-1.712,-1.582,1.1796,-2.563,-1.99,24,63,-0.13,5,5,0,0,"strand",1.9,7.59,0.0005030904125341,6.47410526315789,6.47410517670654,6.47281975099898,5.34879705543722,16,4,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,-3,0,-1,-3,2,0,6,2,-0.433637284701115,-0.408785529715762,0.0429635996765711,-0.436999147485081,-0.520942408376963,0.252631578947368,-0.107084019769357,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","150/150","A:F:Q:V:L:I",1.86781040138793,0.0145043045254536,0.764079088633845,2.44452495713176,1.42623754737775,32.8877353882363,0.811179756363585,0.0192724555107824,1.71506294819644,1.09429403734416,44.2397805449942,0.0207365726835135,"lineage2","dr_mutations_pyrazinamide","LEU",0,"ERR133896,0616W-sc-2012-02-09T18:56:35Z-1355229","ERR133896","lineage2.2.1","ru","Russia,Samara","pnca_p.phe94leu","A","E","PHE","FA94","pnca_complex.pdb"
|
|
"F94L","L4","PZA","F","F94",94,"L",1,"MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",10.621,-1.712,-1.582,1.1796,-2.563,-1.99,24,63,-0.13,5,5,0,0,"strand",1.9,7.59,0.0005030904125341,6.47410526315789,6.47410517670654,6.47281975099898,5.34879705543722,16,4,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,-3,0,-1,-3,2,0,6,2,-0.433637284701115,-0.408785529715762,0.0429635996765711,-0.436999147485081,-0.520942408376963,0.252631578947368,-0.107084019769357,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","150/150","A:F:Q:V:L:I",1.86781040138793,0.0145043045254536,0.764079088633845,2.44452495713176,1.42623754737775,32.8877353882363,0.811179756363585,0.0192724555107824,1.71506294819644,1.09429403734416,44.2397805449942,0.0207365726835135,"lineage4","dr_mutations_pyrazinamide","LEU",0,"ERR1034714","ERR1034714","lineage4.1.1.3","pe","Peru","pnca_p.phe94leu","A","E","PHE","FA94","pnca_complex.pdb"
|
|
"F94L","L4","PZA","F","F94",94,"L",0,"MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",10.621,-1.712,-1.582,1.1796,-2.563,-1.99,24,63,-0.13,5,5,0,0,"strand",1.9,7.59,0.0005030904125341,6.47410526315789,6.47410517670654,6.47281975099898,5.34879705543722,16,4,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,-3,0,-1,-3,2,0,6,2,-0.433637284701115,-0.408785529715762,0.0429635996765711,-0.436999147485081,-0.520942408376963,0.252631578947368,-0.107084019769357,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","150/150","A:F:Q:V:L:I",1.86781040138793,0.0145043045254536,0.764079088633845,2.44452495713176,1.42623754737775,32.8877353882363,0.811179756363585,0.0192724555107824,1.71506294819644,1.09429403734416,44.2397805449942,0.0207365726835135,"lineage4","dr_mutations_pyrazinamide","LEU",0,"ERR2515936","ERR2515936","lineage4.3.3","za","South Africa","pnca_p.phe94leu","A","E","PHE","FA94","pnca_complex.pdb"
|
|
"F94L","L4","PZA","F","F94",94,"L",1,"MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",10.621,-1.712,-1.582,1.1796,-2.563,-1.99,24,63,-0.13,5,5,0,0,"strand",1.9,7.59,0.0005030904125341,6.47410526315789,6.47410517670654,6.47281975099898,5.34879705543722,16,4,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,-3,0,-1,-3,2,0,6,2,-0.433637284701115,-0.408785529715762,0.0429635996765711,-0.436999147485081,-0.520942408376963,0.252631578947368,-0.107084019769357,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","150/150","A:F:Q:V:L:I",1.86781040138793,0.0145043045254536,0.764079088633845,2.44452495713176,1.42623754737775,32.8877353882363,0.811179756363585,0.0192724555107824,1.71506294819644,1.09429403734416,44.2397805449942,0.0207365726835135,"lineage4","dr_mutations_pyrazinamide","LEU",0,"ERR2515506","ERR2515506","lineage4.3.3","za","South Africa","pnca_p.phe94leu","A","E","PHE","FA94","pnca_complex.pdb"
|
|
"F94L","L4","PZA","F","F94",94,"L",1,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",10.621,-1.712,-1.582,1.1796,-2.563,-1.99,24,63,-0.13,5,5,0,0,"strand",1.9,7.59,0.0005030904125341,6.47410526315789,6.47410517670654,6.47281975099898,5.34879705543722,16,4,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,-3,0,-1,-3,2,0,6,2,-0.433637284701115,-0.408785529715762,0.0429635996765711,-0.436999147485081,-0.520942408376963,0.252631578947368,-0.107084019769357,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","150/150","A:F:Q:V:L:I",1.86781040138793,0.0145043045254536,0.764079088633845,2.44452495713176,1.42623754737775,32.8877353882363,0.811179756363585,0.0192724555107824,1.71506294819644,1.09429403734416,44.2397805449942,0.0207365726835135,"lineage4","dr_mutations_pyrazinamide","LEU",0,"ERR137209,1269F-sc-2012-02-21T11:36:27Z-1364701","ERR137209","lineage4.3.3","ru","Russia,Samara","pnca_p.phe94leu","A","E","PHE","FA94","pnca_complex.pdb"
|
|
"F94L","L3","PZA","F","F94",94,"L",0,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",10.621,-1.712,-1.582,1.1796,-2.563,-1.99,24,63,-0.13,5,5,0,0,"strand",1.9,7.59,0.0005030904125341,6.47410526315789,6.47410517670654,6.47281975099898,5.34879705543722,16,4,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,-3,0,-1,-3,2,0,6,2,-0.433637284701115,-0.408785529715762,0.0429635996765711,-0.436999147485081,-0.520942408376963,0.252631578947368,-0.107084019769357,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","150/150","A:F:Q:V:L:I",1.86781040138793,0.0145043045254536,0.764079088633845,2.44452495713176,1.42623754737775,32.8877353882363,0.811179756363585,0.0192724555107824,1.71506294819644,1.09429403734416,44.2397805449942,0.0207365726835135,"lineage3","dr_mutations_pyrazinamide","LEU",0,"ERR2510530","ERR2510530","lineage3","pk","Pakistan","pnca_p.phe94leu","A","E","PHE","FA94","pnca_complex.pdb"
|
|
"F94L","L2","PZA","F","F94",94,"L",NA,"XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",10.621,-1.712,-1.582,1.1796,-2.563,-1.99,24,63,-0.13,5,5,0,0,"strand",1.9,7.59,0.0005030904125341,6.47410526315789,6.47410517670654,6.47281975099898,5.34879705543722,16,4,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,-3,0,-1,-3,2,0,6,2,-0.433637284701115,-0.408785529715762,0.0429635996765711,-0.436999147485081,-0.520942408376963,0.252631578947368,-0.107084019769357,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","150/150","A:F:Q:V:L:I",1.86781040138793,0.0145043045254536,0.764079088633845,2.44452495713176,1.42623754737775,32.8877353882363,0.811179756363585,0.0192724555107824,1.71506294819644,1.09429403734416,44.2397805449942,0.0207365726835135,"lineage2","dr_mutations_pyrazinamide","LEU",0,"SRR671842,BGI_FJ07070","SRR671842","lineage2.2.1","cn","China","pnca_p.phe94leu","A","E","PHE","FA94","pnca_complex.pdb"
|
|
"F94S","L2","PZA","F","F94",94,"S",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",10.621,-0.449,-3.027,5.85272,-3.24,-2.74,69,80,-0.13,5,5,0,0,"strand",1.9,7.59,0.0001437401178668,19.411022297013,511754.463552622,Inf,4.73122070382274,32,4,0,0,4,0,0,0,0,0,0,-2,0,0,0,0,0,-1,0,-3,0,6,0,10,6,-0.113728470111449,-0.782170542635659,0.213168802220296,-0.552429667519182,-0.717277486910995,0.726315789473684,-0.107084019769357,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","150/150","A:F:Q:V:L:I",13.1456002256206,0.924803768446999,139.277183326568,0.0943844491369244,0.0001628371344452,NA,1.28804840845689,0.0292235860951597,1.53426649183163,0.91081598550184,Inf,0.0296198560706035,"lineage2","dr_mutations_pyrazinamide","SER",0,"SAMN07236524,SRR5709885","SRR5709885","lineage2.2.1","th","Thailand","pnca_p.phe94ser","A","E","PHE","FA94","pnca_complex.pdb"
|
|
"F94S","L3","PZA","F","F94",94,"S",1,"MDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",10.621,-0.449,-3.027,5.85272,-3.24,-2.74,69,80,-0.13,5,5,0,0,"strand",1.9,7.59,0.0001437401178668,19.411022297013,511754.463552622,Inf,4.73122070382274,32,4,0,0,4,0,0,0,0,0,0,-2,0,0,0,0,0,-1,0,-3,0,6,0,10,6,-0.113728470111449,-0.782170542635659,0.213168802220296,-0.552429667519182,-0.717277486910995,0.726315789473684,-0.107084019769357,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","150/150","A:F:Q:V:L:I",13.1456002256206,0.924803768446999,139.277183326568,0.0943844491369244,0.0001628371344452,NA,1.28804840845689,0.0292235860951597,1.53426649183163,0.91081598550184,Inf,0.0296198560706035,"lineage3","dr_mutations_pyrazinamide","SER",0,"ERR2516996","ERR2516996","lineage3","gb","UK","pnca_p.phe94ser","A","E","PHE","FA94","pnca_complex.pdb"
|
|
"F94S","L2","PZA","F","F94",94,"S",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",10.621,-0.449,-3.027,5.85272,-3.24,-2.74,69,80,-0.13,5,5,0,0,"strand",1.9,7.59,0.0001437401178668,19.411022297013,511754.463552622,Inf,4.73122070382274,32,4,0,0,4,0,0,0,0,0,0,-2,0,0,0,0,0,-1,0,-3,0,6,0,10,6,-0.113728470111449,-0.782170542635659,0.213168802220296,-0.552429667519182,-0.717277486910995,0.726315789473684,-0.107084019769357,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","150/150","A:F:Q:V:L:I",13.1456002256206,0.924803768446999,139.277183326568,0.0943844491369244,0.0001628371344452,NA,1.28804840845689,0.0292235860951597,1.53426649183163,0.91081598550184,Inf,0.0296198560706035,"lineage2","dr_mutations_pyrazinamide","SER",0,"SRS797175","SRR1723691","lineage2.2.1.1","cn","China:Shanxi","pnca_p.phe94ser","A","E","PHE","FA94","pnca_complex.pdb"
|
|
"F94S","L2","PZA","F","F94",94,"S",1,"Pre-XDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",10.621,-0.449,-3.027,5.85272,-3.24,-2.74,69,80,-0.13,5,5,0,0,"strand",1.9,7.59,0.0001437401178668,19.411022297013,511754.463552622,Inf,4.73122070382274,32,4,0,0,4,0,0,0,0,0,0,-2,0,0,0,0,0,-1,0,-3,0,6,0,10,6,-0.113728470111449,-0.782170542635659,0.213168802220296,-0.552429667519182,-0.717277486910995,0.726315789473684,-0.107084019769357,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","150/150","A:F:Q:V:L:I",13.1456002256206,0.924803768446999,139.277183326568,0.0943844491369244,0.0001628371344452,NA,1.28804840845689,0.0292235860951597,1.53426649183163,0.91081598550184,Inf,0.0296198560706035,"lineage2","dr_mutations_pyrazinamide","SER",0,"MDR_4249","SRR6824389","lineage2.2.1.1","cn","China: Yaodu District, Linfen City, Shanxi Province ","pnca_p.phe94ser","A","E","PHE","FA94","pnca_complex.pdb"
|
|
"F94S","L4","PZA","F","F94",94,"S",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",10.621,-0.449,-3.027,5.85272,-3.24,-2.74,69,80,-0.13,5,5,0,0,"strand",1.9,7.59,0.0001437401178668,19.411022297013,511754.463552622,Inf,4.73122070382274,32,4,0,0,4,0,0,0,0,0,0,-2,0,0,0,0,0,-1,0,-3,0,6,0,10,6,-0.113728470111449,-0.782170542635659,0.213168802220296,-0.552429667519182,-0.717277486910995,0.726315789473684,-0.107084019769357,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","150/150","A:F:Q:V:L:I",13.1456002256206,0.924803768446999,139.277183326568,0.0943844491369244,0.0001628371344452,NA,1.28804840845689,0.0292235860951597,1.53426649183163,0.91081598550184,Inf,0.0296198560706035,"lineage4","dr_mutations_pyrazinamide","SER",0,"SAMN02567705","SRR1166253","lineage4.4.1.1","ro","Romania","pnca_p.phe94ser","A","E","PHE","FA94","pnca_complex.pdb"
|
|
"F94V","L4","PZA","F","F94",94,"V",NA,"MDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",10.621,-1.681,-1.995,2.56655,-2.927,-1.82,-5,53,-0.13,5,5,0,0,"strand",1.9,7.59,7.18700589334483e-05,2.42412778478352,0.0001249735077034,0,1.03410070803344e-29,30,4,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,-1,0,-3,2,4,0,6,2,-0.425785207700101,-0.515503875968992,0.0934793376991382,-0.499062233589088,-0.476439790575916,-0.0537634408602151,-0.107084019769357,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","neutral",-0.332,-0.038,"6:5","150/150","A:F:Q:V:L:I",-8.9874087814964,0.940032862253633,119.46804443549,-0.0752285585987757,NA,4692673.51081231,0.384555509373631,1,0,0,188.544222231268,0.999999999999997,"lineage4","other_mutations_pyrazinamide","VAL",0,"2591","ERR2432995","lineage4.3.3","br","Brazil","pnca_p.phe94val","A","E","PHE","FA94","pnca_complex.pdb"
|
|
"F94V","L2","PZA","F","F94",94,"V",NA,"XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",10.621,-1.681,-1.995,2.56655,-2.927,-1.82,-5,53,-0.13,5,5,0,0,"strand",1.9,7.59,7.18700589334483e-05,2.42412778478352,0.0001249735077034,0,1.03410070803344e-29,30,4,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,-1,0,-3,2,4,0,6,2,-0.425785207700101,-0.515503875968992,0.0934793376991382,-0.499062233589088,-0.476439790575916,-0.0537634408602151,-0.107084019769357,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","neutral",-0.332,-0.038,"6:5","150/150","A:F:Q:V:L:I",-8.9874087814964,0.940032862253633,119.46804443549,-0.0752285585987757,NA,4692673.51081231,0.384555509373631,1,0,0,188.544222231268,0.999999999999997,"lineage2","other_mutations_pyrazinamide","VAL",0,"SRS935976,SAMN03653231","SRR2024926","lineage2.2.1","cn","China","pnca_p.phe94val","A","E","PHE","FA94","pnca_complex.pdb"
|
|
"F94V","L2","PZA","F","F94",94,"V",0,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",10.621,-1.681,-1.995,2.56655,-2.927,-1.82,-5,53,-0.13,5,5,0,0,"strand",1.9,7.59,7.18700589334483e-05,2.42412778478352,0.0001249735077034,0,1.03410070803344e-29,30,4,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,-1,0,-3,2,4,0,6,2,-0.425785207700101,-0.515503875968992,0.0934793376991382,-0.499062233589088,-0.476439790575916,-0.0537634408602151,-0.107084019769357,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","neutral",-0.332,-0.038,"6:5","150/150","A:F:Q:V:L:I",-8.9874087814964,0.940032862253633,119.46804443549,-0.0752285585987757,NA,4692673.51081231,0.384555509373631,1,0,0,188.544222231268,0.999999999999997,"lineage2","other_mutations_pyrazinamide","VAL",0,"ERR2516537","ERR2516537","lineage2.2.1","nl","Netherlands","pnca_p.phe94val","A","E","PHE","FA94","pnca_complex.pdb"
|
|
"Y95D","L2","PZA","Y","Y95",95,"D",NA,"Pre-XDR","OM","hydrophobic","hydrophilic","neutral","acidic","polar","neg",10.528,0.071,-0.772,4.78106,-2.558,-0.4,46,71,-0.013,5,5,75,0.285171102661597,"strand",-0.8,4.15,7.18700589334483e-05,9.70142977291842,188179.926264427,Inf,0.763784339928386,38,-12,0,0,-12,0,0,0,0,2,0,0,2,0,0,0,0,1,0,1,1,4,0,2,2,0.0318385650224215,-0.199483204134367,0.174136612300498,-0.43614663256607,-0.104712041884817,0.484210526315789,-0.0107084019769357,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.244,0.083,"6:5","150/150","K:Y:H:D:G:S:M:P:L:N:C:R:E:F:Q:T",12.1451538387253,0.919026337424197,119.468044436166,0.101660271548303,5.01153666068889e-06,NA,0.986835744238421,0.170978870202674,0.767057556984365,0.124324963210678,Inf,0.382146811758261,"lineage2","other_mutations_pyrazinamide","ASP",0,"ERR2516654","ERR2516654","lineage2.2.1.1","pe","Peru","pnca_p.tyr95asp","A","E","TYR","YA95","pnca_complex.pdb"
|
|
"Y95D","L2","PZA","Y","Y95",95,"D",1,"Pre-XDR","OM","hydrophobic","hydrophilic","neutral","acidic","polar","neg",10.528,0.071,-0.772,4.78106,-2.558,-0.4,46,71,-0.013,5,5,75,0.285171102661597,"strand",-0.8,4.15,7.18700589334483e-05,9.70142977291842,188179.926264427,Inf,0.763784339928386,38,-12,0,0,-12,0,0,0,0,2,0,0,2,0,0,0,0,1,0,1,1,4,0,2,2,0.0318385650224215,-0.199483204134367,0.174136612300498,-0.43614663256607,-0.104712041884817,0.484210526315789,-0.0107084019769357,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.244,0.083,"6:5","150/150","K:Y:H:D:G:S:M:P:L:N:C:R:E:F:Q:T",12.1451538387253,0.919026337424197,119.468044436166,0.101660271548303,5.01153666068889e-06,NA,0.986835744238421,0.170978870202674,0.767057556984365,0.124324963210678,Inf,0.382146811758261,"lineage2","other_mutations_pyrazinamide","ASP",0,"ERR2516727","ERR2516727","lineage2.2.1.1","pe","Peru","pnca_p.tyr95asp","A","E","TYR","YA95","pnca_complex.pdb"
|
|
"K96E","L2","PZA","K","K96",96,"E",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",3.977,-0.673,-2.119,6.92487,-2.7,-1.84,89,91,-1.194,9,9,8,0.0338983050847457,"strand",-1.86666666666667,5.96,0.0007905706482679,107.166385135135,3795803.48339079,Inf,47.6847963834956,26,-2,0,0,-2,0,0,0,0,4,0,-4,4,0,0,0,0,0,0,-2,1,-2,0,0,-2,-0.170466058763931,-0.547545219638243,0.252218839006694,-0.460358056265985,-0.481675392670157,0.936842105263158,-0.983525535420099,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","150/150","K:Q",15.1494066679806,0.925233417916433,161.43254287942,0.0938435732830911,24.1993753459371,NA,2.03005858162844,3.58120158191569e-09,8.44597123233921,12.2081619622864,Inf,5.00558510128865e-12,"lineage2","dr_mutations_pyrazinamide","GLU",0,"SAMN03653224,SRS935964","SRR2024918","lineage2.2.1","cn","China","pnca_p.lys96glu","A","E","LYS","KA96","pnca_complex.pdb"
|
|
"K96E","L2","PZA","K","K96",96,"E",1,"Pre-XDR","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",3.977,-0.673,-2.119,6.92487,-2.7,-1.84,89,91,-1.194,9,9,8,0.0338983050847457,"strand",-1.86666666666667,5.96,0.0007905706482679,107.166385135135,3795803.48339079,Inf,47.6847963834956,26,-2,0,0,-2,0,0,0,0,4,0,-4,4,0,0,0,0,0,0,-2,1,-2,0,0,-2,-0.170466058763931,-0.547545219638243,0.252218839006694,-0.460358056265985,-0.481675392670157,0.936842105263158,-0.983525535420099,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","150/150","K:Q",15.1494066679806,0.925233417916433,161.43254287942,0.0938435732830911,24.1993753459371,NA,2.03005858162844,3.58120158191569e-09,8.44597123233921,12.2081619622864,Inf,5.00558510128865e-12,"lineage2","dr_mutations_pyrazinamide","GLU",0,"ERR229971,2344Z-sc-2012-10-11T13:39:50Z-1494290","ERR229971","lineage2.2.1","ru","Russia,Samara","pnca_p.lys96glu","A","E","LYS","KA96","pnca_complex.pdb"
|
|
"K96E","L2","PZA","K","K96",96,"E",1,"MDR","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",3.977,-0.673,-2.119,6.92487,-2.7,-1.84,89,91,-1.194,9,9,8,0.0338983050847457,"strand",-1.86666666666667,5.96,0.0007905706482679,107.166385135135,3795803.48339079,Inf,47.6847963834956,26,-2,0,0,-2,0,0,0,0,4,0,-4,4,0,0,0,0,0,0,-2,1,-2,0,0,-2,-0.170466058763931,-0.547545219638243,0.252218839006694,-0.460358056265985,-0.481675392670157,0.936842105263158,-0.983525535420099,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","150/150","K:Q",15.1494066679806,0.925233417916433,161.43254287942,0.0938435732830911,24.1993753459371,NA,2.03005858162844,3.58120158191569e-09,8.44597123233921,12.2081619622864,Inf,5.00558510128865e-12,"lineage2","dr_mutations_pyrazinamide","GLU",0,"ERR2041720","ERR2041720","lineage2.2.1","rs","Serbia","pnca_p.lys96glu","A","E","LYS","KA96","pnca_complex.pdb"
|
|
"K96E","L4","PZA","K","K96",96,"E",NA,"MDR","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",3.977,-0.673,-2.119,6.92487,-2.7,-1.84,89,91,-1.194,9,9,8,0.0338983050847457,"strand",-1.86666666666667,5.96,0.0007905706482679,107.166385135135,3795803.48339079,Inf,47.6847963834956,26,-2,0,0,-2,0,0,0,0,4,0,-4,4,0,0,0,0,0,0,-2,1,-2,0,0,-2,-0.170466058763931,-0.547545219638243,0.252218839006694,-0.460358056265985,-0.481675392670157,0.936842105263158,-0.983525535420099,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","150/150","K:Q",15.1494066679806,0.925233417916433,161.43254287942,0.0938435732830911,24.1993753459371,NA,2.03005858162844,3.58120158191569e-09,8.44597123233921,12.2081619622864,Inf,5.00558510128865e-12,"lineage4","dr_mutations_pyrazinamide","GLU",0,"ERR2679263","ERR2679263","lineage4.1","","","pnca_p.lys96glu","A","E","LYS","KA96","pnca_complex.pdb"
|
|
"K96E","L2","PZA","K","K96",96,"E",1,"Pre-XDR","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",3.977,-0.673,-2.119,6.92487,-2.7,-1.84,89,91,-1.194,9,9,8,0.0338983050847457,"strand",-1.86666666666667,5.96,0.0007905706482679,107.166385135135,3795803.48339079,Inf,47.6847963834956,26,-2,0,0,-2,0,0,0,0,4,0,-4,4,0,0,0,0,0,0,-2,1,-2,0,0,-2,-0.170466058763931,-0.547545219638243,0.252218839006694,-0.460358056265985,-0.481675392670157,0.936842105263158,-0.983525535420099,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","150/150","K:Q",15.1494066679806,0.925233417916433,161.43254287942,0.0938435732830911,24.1993753459371,NA,2.03005858162844,3.58120158191569e-09,8.44597123233921,12.2081619622864,Inf,5.00558510128865e-12,"lineage2","dr_mutations_pyrazinamide","GLU",0,"MDR_23356","SRR6824482","lineage2.2.2","cn","China: Wusheng County, Guang'an City, Sichuan Province","pnca_p.lys96glu","A","E","LYS","KA96","pnca_complex.pdb"
|
|
"K96E","L2","PZA","K","K96",96,"E",1,"Pre-XDR","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",3.977,-0.673,-2.119,6.92487,-2.7,-1.84,89,91,-1.194,9,9,8,0.0338983050847457,"strand",-1.86666666666667,5.96,0.0007905706482679,107.166385135135,3795803.48339079,Inf,47.6847963834956,26,-2,0,0,-2,0,0,0,0,4,0,-4,4,0,0,0,0,0,0,-2,1,-2,0,0,-2,-0.170466058763931,-0.547545219638243,0.252218839006694,-0.460358056265985,-0.481675392670157,0.936842105263158,-0.983525535420099,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","150/150","K:Q",15.1494066679806,0.925233417916433,161.43254287942,0.0938435732830911,24.1993753459371,NA,2.03005858162844,3.58120158191569e-09,8.44597123233921,12.2081619622864,Inf,5.00558510128865e-12,"lineage2","dr_mutations_pyrazinamide","GLU",0,"2207A-sc-2012-10-11T13:38:11Z-1494188,ERR228024","ERR228024","lineage2.2.1","ru","Russia,Samara","pnca_p.lys96glu","A","E","LYS","KA96","pnca_complex.pdb"
|
|
"K96E","L2","PZA","K","K96",96,"E",1,"Pre-XDR","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",3.977,-0.673,-2.119,6.92487,-2.7,-1.84,89,91,-1.194,9,9,8,0.0338983050847457,"strand",-1.86666666666667,5.96,0.0007905706482679,107.166385135135,3795803.48339079,Inf,47.6847963834956,26,-2,0,0,-2,0,0,0,0,4,0,-4,4,0,0,0,0,0,0,-2,1,-2,0,0,-2,-0.170466058763931,-0.547545219638243,0.252218839006694,-0.460358056265985,-0.481675392670157,0.936842105263158,-0.983525535420099,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","150/150","K:Q",15.1494066679806,0.925233417916433,161.43254287942,0.0938435732830911,24.1993753459371,NA,2.03005858162844,3.58120158191569e-09,8.44597123233921,12.2081619622864,Inf,5.00558510128865e-12,"lineage2","dr_mutations_pyrazinamide","GLU",0,"ERS2592738","ERR2677387","lineage2.2.1","de","Germany","pnca_p.lys96glu","A","E","LYS","KA96","pnca_complex.pdb"
|
|
"K96E","L4","PZA","K","K96",96,"E",1,"Pre-MDR","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",3.977,-0.673,-2.119,6.92487,-2.7,-1.84,89,91,-1.194,9,9,8,0.0338983050847457,"strand",-1.86666666666667,5.96,0.0007905706482679,107.166385135135,3795803.48339079,Inf,47.6847963834956,26,-2,0,0,-2,0,0,0,0,4,0,-4,4,0,0,0,0,0,0,-2,1,-2,0,0,-2,-0.170466058763931,-0.547545219638243,0.252218839006694,-0.460358056265985,-0.481675392670157,0.936842105263158,-0.983525535420099,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","150/150","K:Q",15.1494066679806,0.925233417916433,161.43254287942,0.0938435732830911,24.1993753459371,NA,2.03005858162844,3.58120158191569e-09,8.44597123233921,12.2081619622864,Inf,5.00558510128865e-12,"lineage4","dr_mutations_pyrazinamide","GLU",0,"ERR2514666","ERR2514666","lineage4.1.1.3","gb","UK","pnca_p.lys96glu","A","E","LYS","KA96","pnca_complex.pdb"
|
|
"K96E","L3","PZA","K","K96",96,"E",1,"MDR","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",3.977,-0.673,-2.119,6.92487,-2.7,-1.84,89,91,-1.194,9,9,8,0.0338983050847457,"strand",-1.86666666666667,5.96,0.0007905706482679,107.166385135135,3795803.48339079,Inf,47.6847963834956,26,-2,0,0,-2,0,0,0,0,4,0,-4,4,0,0,0,0,0,0,-2,1,-2,0,0,-2,-0.170466058763931,-0.547545219638243,0.252218839006694,-0.460358056265985,-0.481675392670157,0.936842105263158,-0.983525535420099,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","150/150","K:Q",15.1494066679806,0.925233417916433,161.43254287942,0.0938435732830911,24.1993753459371,NA,2.03005858162844,3.58120158191569e-09,8.44597123233921,12.2081619622864,Inf,5.00558510128865e-12,"lineage3","dr_mutations_pyrazinamide","GLU",0,"ERR2510317","ERR2510317","lineage3","pk","Pakistan","pnca_p.lys96glu","A","E","LYS","KA96","pnca_complex.pdb"
|
|
"K96E","L4","PZA","K","K96",96,"E",1,"Pre-MDR","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",3.977,-0.673,-2.119,6.92487,-2.7,-1.84,89,91,-1.194,9,9,8,0.0338983050847457,"strand",-1.86666666666667,5.96,0.0007905706482679,107.166385135135,3795803.48339079,Inf,47.6847963834956,26,-2,0,0,-2,0,0,0,0,4,0,-4,4,0,0,0,0,0,0,-2,1,-2,0,0,-2,-0.170466058763931,-0.547545219638243,0.252218839006694,-0.460358056265985,-0.481675392670157,0.936842105263158,-0.983525535420099,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","150/150","K:Q",15.1494066679806,0.925233417916433,161.43254287942,0.0938435732830911,24.1993753459371,NA,2.03005858162844,3.58120158191569e-09,8.44597123233921,12.2081619622864,Inf,5.00558510128865e-12,"lineage4","dr_mutations_pyrazinamide","GLU",0,"SAMN03647894,SRR2100721","SRR2100721","lineage4.1.1.3","","","pnca_p.lys96glu","A","E","LYS","KA96","pnca_complex.pdb"
|
|
"K96E","L2","PZA","K","K96",96,"E",1,"MDR","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",3.977,-0.673,-2.119,6.92487,-2.7,-1.84,89,91,-1.194,9,9,8,0.0338983050847457,"strand",-1.86666666666667,5.96,0.0007905706482679,107.166385135135,3795803.48339079,Inf,47.6847963834956,26,-2,0,0,-2,0,0,0,0,4,0,-4,4,0,0,0,0,0,0,-2,1,-2,0,0,-2,-0.170466058763931,-0.547545219638243,0.252218839006694,-0.460358056265985,-0.481675392670157,0.936842105263158,-0.983525535420099,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","150/150","K:Q",15.1494066679806,0.925233417916433,161.43254287942,0.0938435732830911,24.1993753459371,NA,2.03005858162844,3.58120158191569e-09,8.44597123233921,12.2081619622864,Inf,5.00558510128865e-12,"lineage2","dr_mutations_pyrazinamide","GLU",0,"ERR067714,1558V-sc-2011-09-07T13:20:10Z-1276561","ERR067714","lineage2.2.1","ru","Russia,Samara","pnca_p.lys96glu","A","E","LYS","KA96","pnca_complex.pdb"
|
|
"K96E","L3","PZA","K","K96",96,"E",1,"MDR","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",3.977,-0.673,-2.119,6.92487,-2.7,-1.84,89,91,-1.194,9,9,8,0.0338983050847457,"strand",-1.86666666666667,5.96,0.0007905706482679,107.166385135135,3795803.48339079,Inf,47.6847963834956,26,-2,0,0,-2,0,0,0,0,4,0,-4,4,0,0,0,0,0,0,-2,1,-2,0,0,-2,-0.170466058763931,-0.547545219638243,0.252218839006694,-0.460358056265985,-0.481675392670157,0.936842105263158,-0.983525535420099,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","150/150","K:Q",15.1494066679806,0.925233417916433,161.43254287942,0.0938435732830911,24.1993753459371,NA,2.03005858162844,3.58120158191569e-09,8.44597123233921,12.2081619622864,Inf,5.00558510128865e-12,"lineage3","dr_mutations_pyrazinamide","GLU",0,"ERS2592789","ERR2677444","lineage3.1.2.1","de","Germany","pnca_p.lys96glu","A","E","LYS","KA96","pnca_complex.pdb"
|
|
"K96E","L4","PZA","K","K96",96,"E",NA,"MDR","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",3.977,-0.673,-2.119,6.92487,-2.7,-1.84,89,91,-1.194,9,9,8,0.0338983050847457,"strand",-1.86666666666667,5.96,0.0007905706482679,107.166385135135,3795803.48339079,Inf,47.6847963834956,26,-2,0,0,-2,0,0,0,0,4,0,-4,4,0,0,0,0,0,0,-2,1,-2,0,0,-2,-0.170466058763931,-0.547545219638243,0.252218839006694,-0.460358056265985,-0.481675392670157,0.936842105263158,-0.983525535420099,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","150/150","K:Q",15.1494066679806,0.925233417916433,161.43254287942,0.0938435732830911,24.1993753459371,NA,2.03005858162844,3.58120158191569e-09,8.44597123233921,12.2081619622864,Inf,5.00558510128865e-12,"lineage4","dr_mutations_pyrazinamide","GLU",0,"SAMN02231159","SRR998767_SRR998764_SRR998766_SRR998765","lineage4.1","ml","Mali","pnca_p.lys96glu","A","E","LYS","KA96","pnca_complex.pdb"
|
|
"K96E","L4","PZA","K","K96",96,"E",1,"Pre-XDR","DM","hydrophobic","hydrophilic","basic","acidic","pos","neg",3.977,-0.673,-2.119,6.92487,-2.7,-1.84,89,91,-1.194,9,9,8,0.0338983050847457,"strand",-1.86666666666667,5.96,0.0007905706482679,107.166385135135,3795803.48339079,Inf,47.6847963834956,26,-2,0,0,-2,0,0,0,0,4,0,-4,4,0,0,0,0,0,0,-2,1,-2,0,0,-2,-0.170466058763931,-0.547545219638243,0.252218839006694,-0.460358056265985,-0.481675392670157,0.936842105263158,-0.983525535420099,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","150/150","K:Q",15.1494066679806,0.925233417916433,161.43254287942,0.0938435732830911,24.1993753459371,NA,2.03005858162844,3.58120158191569e-09,8.44597123233921,12.2081619622864,Inf,5.00558510128865e-12,"lineage4","dr_mutations_pyrazinamide","GLU",0,"ERR2516531","ERR2516531","lineage4.1.2.1","pe","Peru","pnca_p.lys96glu","A","E","LYS","KA96","pnca_complex.pdb"
|
|
"K96M","L6","PZA","K","K96",96,"M",NA,"MDR","OM","hydrophobic","hydrophobic","basic","non-polar","pos","non-polar",3.977,-1.026,0.413,0.273257,-0.457,1.02,84,91,-1.194,9,9,8,0.0338983050847457,"strand",-1.86666666666667,5.96,0.0001437401178668,19.411022297013,511754.463553382,Inf,4.73122070382274,24,32,0,0,32,0,0,0,0,4,0,0,4,0,0,0,0,-5,0,-5,0,-2,0,-2,-4,-0.259878419452887,0.351190476190476,0.0099526147480678,-0.077919863597613,0.573033707865168,0.884210526315789,-0.983525535420099,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.229,-1.178,"9:9","150/150","K:Q",13.1456002256221,0.924803768447045,139.277183326669,0.0943844491368667,0.0001628371344428,NA,1.28804840845689,0.0292235860951597,1.53426649183163,0.91081598550184,Inf,0.0296198560706035,"lineage6","other_mutations_pyrazinamide","MET",0,"ERR181315","ERR181315","lineage6","so","Somalia","pnca_p.lys96met","A","E","LYS","KA96","pnca_complex.pdb"
|
|
"K96M","L2","PZA","K","K96",96,"M",NA,"MDR","OM","hydrophobic","hydrophobic","basic","non-polar","pos","non-polar",3.977,-1.026,0.413,0.273257,-0.457,1.02,84,91,-1.194,9,9,8,0.0338983050847457,"strand",-1.86666666666667,5.96,0.0001437401178668,19.411022297013,511754.463553382,Inf,4.73122070382274,24,32,0,0,32,0,0,0,0,4,0,0,4,0,0,0,0,-5,0,-5,0,-2,0,-2,-4,-0.259878419452887,0.351190476190476,0.0099526147480678,-0.077919863597613,0.573033707865168,0.884210526315789,-0.983525535420099,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.229,-1.178,"9:9","150/150","K:Q",13.1456002256221,0.924803768447045,139.277183326669,0.0943844491368667,0.0001628371344428,NA,1.28804840845689,0.0292235860951597,1.53426649183163,0.91081598550184,Inf,0.0296198560706035,"lineage2","other_mutations_pyrazinamide","MET",0,"SRS797003","SRR1723498","lineage2.2.1","cn","China:Ningxia","pnca_p.lys96met","A","E","LYS","KA96","pnca_complex.pdb"
|
|
"K96M","L3","PZA","K","K96",96,"M",1,"MDR","OM","hydrophobic","hydrophobic","basic","non-polar","pos","non-polar",3.977,-1.026,0.413,0.273257,-0.457,1.02,84,91,-1.194,9,9,8,0.0338983050847457,"strand",-1.86666666666667,5.96,0.0001437401178668,19.411022297013,511754.463553382,Inf,4.73122070382274,24,32,0,0,32,0,0,0,0,4,0,0,4,0,0,0,0,-5,0,-5,0,-2,0,-2,-4,-0.259878419452887,0.351190476190476,0.0099526147480678,-0.077919863597613,0.573033707865168,0.884210526315789,-0.983525535420099,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.229,-1.178,"9:9","150/150","K:Q",13.1456002256221,0.924803768447045,139.277183326669,0.0943844491368667,0.0001628371344428,NA,1.28804840845689,0.0292235860951597,1.53426649183163,0.91081598550184,Inf,0.0296198560706035,"lineage3","other_mutations_pyrazinamide","MET",0,"ERR2510456","ERR2510456","lineage3","pk","Pakistan","pnca_p.lys96met","A","E","LYS","KA96","pnca_complex.pdb"
|
|
"K96M","L2","PZA","K","K96",96,"M",1,"MDR","OM","hydrophobic","hydrophobic","basic","non-polar","pos","non-polar",3.977,-1.026,0.413,0.273257,-0.457,1.02,84,91,-1.194,9,9,8,0.0338983050847457,"strand",-1.86666666666667,5.96,0.0001437401178668,19.411022297013,511754.463553382,Inf,4.73122070382274,24,32,0,0,32,0,0,0,0,4,0,0,4,0,0,0,0,-5,0,-5,0,-2,0,-2,-4,-0.259878419452887,0.351190476190476,0.0099526147480678,-0.077919863597613,0.573033707865168,0.884210526315789,-0.983525535420099,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.229,-1.178,"9:9","150/150","K:Q",13.1456002256221,0.924803768447045,139.277183326669,0.0943844491368667,0.0001628371344428,NA,1.28804840845689,0.0292235860951597,1.53426649183163,0.91081598550184,Inf,0.0296198560706035,"lineage2","other_mutations_pyrazinamide","MET",0,"MDR_30119","SRR6824312","lineage2.2.1","cn","China: Haiyuan County, Ningxia Zhongwei City, Ningxia Province","pnca_p.lys96met","A","E","LYS","KA96","pnca_complex.pdb"
|
|
"K96N","L2","PZA","K","K96",96,"N",0,"MDR","DM","hydrophobic","hydrophilic","basic","neutral","pos","polar",3.977,0.325,-1.156,2.61245,-3.151,-0.85,90,95,-1.194,9,9,8,0.0338983050847457,"strand",-1.86666666666667,5.96,7.18700589334483e-05,2.42412778478352,0.0001249735077034,0,1.03410070803344e-29,52,6,0,0,6,0,0,0,0,4,0,2,0,0,0,0,0,-3,0,-1,-3,6,0,4,-2,0.145739910313901,-0.298708010335917,0.0951511156112734,-0.537254901960784,-0.222513089005236,0.947368421052632,-0.983525535420099,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","150/150","K:Q",-8.98740878149641,0.940032862253633,119.468044435491,-0.0752285585987751,NA,4692673.51081327,0.384555509373631,1,0,0,188.544222231268,0.999999999999997,"lineage2","dr_mutations_pyrazinamide","ASN",0,"MDR_19128","SRR6824521","lineage2.2.1","cn","China: Zengcheng City, Guangzhou City, Guangdong Province","pnca_p.lys96asn","A","E","LYS","KA96","pnca_complex.pdb"
|
|
"K96N","L4","PZA","K","K96",96,"N",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","basic","neutral","pos","polar",3.977,0.325,-1.156,2.61245,-3.151,-0.85,90,95,-1.194,9,9,8,0.0338983050847457,"strand",-1.86666666666667,5.96,7.18700589334483e-05,2.42412778478352,0.0001249735077034,0,1.03410070803344e-29,52,6,0,0,6,0,0,0,0,4,0,2,0,0,0,0,0,-3,0,-1,-3,6,0,4,-2,0.145739910313901,-0.298708010335917,0.0951511156112734,-0.537254901960784,-0.222513089005236,0.947368421052632,-0.983525535420099,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","150/150","K:Q",-8.98740878149641,0.940032862253633,119.468044435491,-0.0752285585987751,NA,4692673.51081327,0.384555509373631,1,0,0,188.544222231268,0.999999999999997,"lineage4","dr_mutations_pyrazinamide","ASN",0,"SRR5818640","SRR5818640","lineage4.6","dj","Djibouti","pnca_p.lys96asn","A","E","LYS","KA96","pnca_complex.pdb"
|
|
"K96N","L2","PZA","K","K96",96,"N",NA,"MDR","DM","hydrophobic","hydrophilic","basic","neutral","pos","polar",3.977,0.325,-1.156,2.61245,-3.151,-0.85,90,95,-1.194,9,9,8,0.0338983050847457,"strand",-1.86666666666667,5.96,7.18700589334483e-05,2.42412778478352,0.0001249735077034,0,1.03410070803344e-29,52,6,0,0,6,0,0,0,0,4,0,2,0,0,0,0,0,-3,0,-1,-3,6,0,4,-2,0.145739910313901,-0.298708010335917,0.0951511156112734,-0.537254901960784,-0.222513089005236,0.947368421052632,-0.983525535420099,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","150/150","K:Q",-8.98740878149641,0.940032862253633,119.468044435491,-0.0752285585987751,NA,4692673.51081327,0.384555509373631,1,0,0,188.544222231268,0.999999999999997,"lineage2","dr_mutations_pyrazinamide","ASN",0,"SRS797343","SRR1723877","lineage2.2.1","cn","China:Guangdong","pnca_p.lys96asn","A","E","LYS","KA96","pnca_complex.pdb"
|
|
"K96N","L2","PZA","K","K96",96,"N",NA,"MDR","DM","hydrophobic","hydrophilic","basic","neutral","pos","polar",3.977,0.325,-1.156,2.61245,-3.151,-0.85,90,95,-1.194,9,9,8,0.0338983050847457,"strand",-1.86666666666667,5.96,7.18700589334483e-05,2.42412778478352,0.0001249735077034,0,1.03410070803344e-29,52,6,0,0,6,0,0,0,0,4,0,2,0,0,0,0,0,-3,0,-1,-3,6,0,4,-2,0.145739910313901,-0.298708010335917,0.0951511156112734,-0.537254901960784,-0.222513089005236,0.947368421052632,-0.983525535420099,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","150/150","K:Q",-8.98740878149641,0.940032862253633,119.468044435491,-0.0752285585987751,NA,4692673.51081327,0.384555509373631,1,0,0,188.544222231268,0.999999999999997,"lineage2","dr_mutations_pyrazinamide","ASN",0,"SRR5074123","SRR5074123","lineage2.2.1","vn","Vietnam","pnca_p.lys96asn","A","E","LYS","KA96","pnca_complex.pdb"
|
|
"K96N","L4","PZA","K","K96",96,"N",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","basic","neutral","pos","polar",3.977,0.325,-1.156,2.61245,-3.151,-0.85,90,95,-1.194,9,9,8,0.0338983050847457,"strand",-1.86666666666667,5.96,7.18700589334483e-05,2.42412778478352,0.0001249735077034,0,1.03410070803344e-29,52,6,0,0,6,0,0,0,0,4,0,2,0,0,0,0,0,-3,0,-1,-3,6,0,4,-2,0.145739910313901,-0.298708010335917,0.0951511156112734,-0.537254901960784,-0.222513089005236,0.947368421052632,-0.983525535420099,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","150/150","K:Q",-8.98740878149641,0.940032862253633,119.468044435491,-0.0752285585987751,NA,4692673.51081327,0.384555509373631,1,0,0,188.544222231268,0.999999999999997,"lineage4","dr_mutations_pyrazinamide","ASN",0,"SRR5818633","SRR5818633","lineage4.6","dj","Djibouti","pnca_p.lys96asn","A","E","LYS","KA96","pnca_complex.pdb"
|
|
"K96Q","L2","PZA","K","K96",96,"Q",0,"Pre-XDR","DM","hydrophobic","hydrophilic","basic","neutral","pos","polar",3.977,-0.08,-1.318,1.04409,-1.359,-0.86,78,85,-1.194,9,9,8,0.0338983050847457,"strand",-1.86666666666667,5.96,0.0002874802357337,4.85191417753471,4.85191414039981,4.85118443551178,1.17497090855698,26,8,0,0,8,0,0,0,0,0,0,-2,0,0,0,0,0,-2,0,-2,-1,2,0,2,-2,-0.0202634245187436,-0.340568475452196,0.0380280305072152,-0.231713554987212,-0.225130890052356,0.821052631578947,-0.983525535420099,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","150/150","K:Q",1.57937329521209,0.114342297004304,1.0002536454007,1.57897279602454,0.58188909131153,40.4562911075298,0.685913110299906,0.137954936368295,0.860262754777729,0.351471331417763,67.0421060419706,0.278382201819561,"lineage2","dr_mutations_pyrazinamide","GLN",0,"ERR2517049","ERR2517049","lineage2.2.1","gb","UK","pnca_p.lys96gln","A","E","LYS","KA96","pnca_complex.pdb"
|
|
"K96Q","L2","PZA","K","K96",96,"Q",1,"Pre-XDR","DM","hydrophobic","hydrophilic","basic","neutral","pos","polar",3.977,-0.08,-1.318,1.04409,-1.359,-0.86,78,85,-1.194,9,9,8,0.0338983050847457,"strand",-1.86666666666667,5.96,0.0002874802357337,4.85191417753471,4.85191414039981,4.85118443551178,1.17497090855698,26,8,0,0,8,0,0,0,0,0,0,-2,0,0,0,0,0,-2,0,-2,-1,2,0,2,-2,-0.0202634245187436,-0.340568475452196,0.0380280305072152,-0.231713554987212,-0.225130890052356,0.821052631578947,-0.983525535420099,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","150/150","K:Q",1.57937329521209,0.114342297004304,1.0002536454007,1.57897279602454,0.58188909131153,40.4562911075298,0.685913110299906,0.137954936368295,0.860262754777729,0.351471331417763,67.0421060419706,0.278382201819561,"lineage2","dr_mutations_pyrazinamide","GLN",0,"ETB0044","SRR6257105","lineage2.2.1","ru","Russia:North Osetia","pnca_p.lys96gln","A","E","LYS","KA96","pnca_complex.pdb"
|
|
"K96Q","L2","PZA","K","K96",96,"Q",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","basic","neutral","pos","polar",3.977,-0.08,-1.318,1.04409,-1.359,-0.86,78,85,-1.194,9,9,8,0.0338983050847457,"strand",-1.86666666666667,5.96,0.0002874802357337,4.85191417753471,4.85191414039981,4.85118443551178,1.17497090855698,26,8,0,0,8,0,0,0,0,0,0,-2,0,0,0,0,0,-2,0,-2,-1,2,0,2,-2,-0.0202634245187436,-0.340568475452196,0.0380280305072152,-0.231713554987212,-0.225130890052356,0.821052631578947,-0.983525535420099,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","150/150","K:Q",1.57937329521209,0.114342297004304,1.0002536454007,1.57897279602454,0.58188909131153,40.4562911075298,0.685913110299906,0.137954936368295,0.860262754777729,0.351471331417763,67.0421060419706,0.278382201819561,"lineage2","dr_mutations_pyrazinamide","GLN",0,"SRR6280158","SRR6280158","lineage2.2.1","cn","China","pnca_p.lys96gln","A","E","LYS","KA96","pnca_complex.pdb"
|
|
"K96Q","L2","PZA","K","K96",96,"Q",0,"Pre-XDR","DM","hydrophobic","hydrophilic","basic","neutral","pos","polar",3.977,-0.08,-1.318,1.04409,-1.359,-0.86,78,85,-1.194,9,9,8,0.0338983050847457,"strand",-1.86666666666667,5.96,0.0002874802357337,4.85191417753471,4.85191414039981,4.85118443551178,1.17497090855698,26,8,0,0,8,0,0,0,0,0,0,-2,0,0,0,0,0,-2,0,-2,-1,2,0,2,-2,-0.0202634245187436,-0.340568475452196,0.0380280305072152,-0.231713554987212,-0.225130890052356,0.821052631578947,-0.983525535420099,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","150/150","K:Q",1.57937329521209,0.114342297004304,1.0002536454007,1.57897279602454,0.58188909131153,40.4562911075298,0.685913110299906,0.137954936368295,0.860262754777729,0.351471331417763,67.0421060419706,0.278382201819561,"lineage2","dr_mutations_pyrazinamide","GLN",0,"ERR2513441","ERR2513441","lineage2.2.1","gb","UK","pnca_p.lys96gln","A","E","LYS","KA96","pnca_complex.pdb"
|
|
"K96Q","L2","PZA","K","K96",96,"Q",1,"MDR","DM","hydrophobic","hydrophilic","basic","neutral","pos","polar",3.977,-0.08,-1.318,1.04409,-1.359,-0.86,78,85,-1.194,9,9,8,0.0338983050847457,"strand",-1.86666666666667,5.96,0.0002874802357337,4.85191417753471,4.85191414039981,4.85118443551178,1.17497090855698,26,8,0,0,8,0,0,0,0,0,0,-2,0,0,0,0,0,-2,0,-2,-1,2,0,2,-2,-0.0202634245187436,-0.340568475452196,0.0380280305072152,-0.231713554987212,-0.225130890052356,0.821052631578947,-0.983525535420099,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","150/150","K:Q",1.57937329521209,0.114342297004304,1.0002536454007,1.57897279602454,0.58188909131153,40.4562911075298,0.685913110299906,0.137954936368295,0.860262754777729,0.351471331417763,67.0421060419706,0.278382201819561,"lineage2","dr_mutations_pyrazinamide","GLN",0,"SAMEA2534129,ERR551701,ERS457531","ERR551701","lineage2.2.1","uz","Nukus","pnca_p.lys96gln","A","E","LYS","KA96","pnca_complex.pdb"
|
|
"K96Q","L2","PZA","K","K96",96,"Q",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","basic","neutral","pos","polar",3.977,-0.08,-1.318,1.04409,-1.359,-0.86,78,85,-1.194,9,9,8,0.0338983050847457,"strand",-1.86666666666667,5.96,0.0002874802357337,4.85191417753471,4.85191414039981,4.85118443551178,1.17497090855698,26,8,0,0,8,0,0,0,0,0,0,-2,0,0,0,0,0,-2,0,-2,-1,2,0,2,-2,-0.0202634245187436,-0.340568475452196,0.0380280305072152,-0.231713554987212,-0.225130890052356,0.821052631578947,-0.983525535420099,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","150/150","K:Q",1.57937329521209,0.114342297004304,1.0002536454007,1.57897279602454,0.58188909131153,40.4562911075298,0.685913110299906,0.137954936368295,0.860262754777729,0.351471331417763,67.0421060419706,0.278382201819561,"lineage2","dr_mutations_pyrazinamide","GLN",0,"SRR6280213","SRR6280213","lineage2.2.1","cn","China","pnca_p.lys96gln","A","E","LYS","KA96","pnca_complex.pdb"
|
|
"K96Q","L2","PZA","K","K96",96,"Q",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","basic","neutral","pos","polar",3.977,-0.08,-1.318,1.04409,-1.359,-0.86,78,85,-1.194,9,9,8,0.0338983050847457,"strand",-1.86666666666667,5.96,0.0002874802357337,4.85191417753471,4.85191414039981,4.85118443551178,1.17497090855698,26,8,0,0,8,0,0,0,0,0,0,-2,0,0,0,0,0,-2,0,-2,-1,2,0,2,-2,-0.0202634245187436,-0.340568475452196,0.0380280305072152,-0.231713554987212,-0.225130890052356,0.821052631578947,-0.983525535420099,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","150/150","K:Q",1.57937329521209,0.114342297004304,1.0002536454007,1.57897279602454,0.58188909131153,40.4562911075298,0.685913110299906,0.137954936368295,0.860262754777729,0.351471331417763,67.0421060419706,0.278382201819561,"lineage2","dr_mutations_pyrazinamide","GLN",0,"SRS935981,SAMN03653255","SRR2024952","lineage2.2.1","cn","China","pnca_p.lys96gln","A","E","LYS","KA96","pnca_complex.pdb"
|
|
"K96Q","L2","PZA","K","K96",96,"Q",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","basic","neutral","pos","polar",3.977,-0.08,-1.318,1.04409,-1.359,-0.86,78,85,-1.194,9,9,8,0.0338983050847457,"strand",-1.86666666666667,5.96,0.0002874802357337,4.85191417753471,4.85191414039981,4.85118443551178,1.17497090855698,26,8,0,0,8,0,0,0,0,0,0,-2,0,0,0,0,0,-2,0,-2,-1,2,0,2,-2,-0.0202634245187436,-0.340568475452196,0.0380280305072152,-0.231713554987212,-0.225130890052356,0.821052631578947,-0.983525535420099,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","150/150","K:Q",1.57937329521209,0.114342297004304,1.0002536454007,1.57897279602454,0.58188909131153,40.4562911075298,0.685913110299906,0.137954936368295,0.860262754777729,0.351471331417763,67.0421060419706,0.278382201819561,"lineage2","dr_mutations_pyrazinamide","GLN",0,"SRR6280156","SRR6280156","lineage2.2.1","cn","China","pnca_p.lys96gln","A","E","LYS","KA96","pnca_complex.pdb"
|
|
"K96Q","L2","PZA","K","K96",96,"Q",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","basic","neutral","pos","polar",3.977,-0.08,-1.318,1.04409,-1.359,-0.86,78,85,-1.194,9,9,8,0.0338983050847457,"strand",-1.86666666666667,5.96,0.0002874802357337,4.85191417753471,4.85191414039981,4.85118443551178,1.17497090855698,26,8,0,0,8,0,0,0,0,0,0,-2,0,0,0,0,0,-2,0,-2,-1,2,0,2,-2,-0.0202634245187436,-0.340568475452196,0.0380280305072152,-0.231713554987212,-0.225130890052356,0.821052631578947,-0.983525535420099,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","150/150","K:Q",1.57937329521209,0.114342297004304,1.0002536454007,1.57897279602454,0.58188909131153,40.4562911075298,0.685913110299906,0.137954936368295,0.860262754777729,0.351471331417763,67.0421060419706,0.278382201819561,"lineage2","dr_mutations_pyrazinamide","GLN",0,"SRS935982,SAMN03653254","SRR2024951","lineage2.2.1","cn","China","pnca_p.lys96gln","A","E","LYS","KA96","pnca_complex.pdb"
|
|
"K96Q","L4","PZA","K","K96",96,"Q",NA,"Pre-MDR","DM","hydrophobic","hydrophilic","basic","neutral","pos","polar",3.977,-0.08,-1.318,1.04409,-1.359,-0.86,78,85,-1.194,9,9,8,0.0338983050847457,"strand",-1.86666666666667,5.96,0.0002874802357337,4.85191417753471,4.85191414039981,4.85118443551178,1.17497090855698,26,8,0,0,8,0,0,0,0,0,0,-2,0,0,0,0,0,-2,0,-2,-1,2,0,2,-2,-0.0202634245187436,-0.340568475452196,0.0380280305072152,-0.231713554987212,-0.225130890052356,0.821052631578947,-0.983525535420099,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","150/150","K:Q",1.57937329521209,0.114342297004304,1.0002536454007,1.57897279602454,0.58188909131153,40.4562911075298,0.685913110299906,0.137954936368295,0.860262754777729,0.351471331417763,67.0421060419706,0.278382201819561,"lineage4","dr_mutations_pyrazinamide","GLN",0,"SRR5067671","SRR5067671","lineage4.1.2.1","vn","Vietnam","pnca_p.lys96gln","A","E","LYS","KA96","pnca_complex.pdb"
|
|
"K96R","L2","PZA","K","K96",96,"R",0,"Pre-XDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",3.977,0.083,-0.169,-0.740521,-2.045,-0.35,85,91,-1.194,9,9,8,0.0338983050847457,"strand",-1.86666666666667,5.96,0.0010780508840017,19.4879594423321,19.4879432617414,19.4791388432651,37.591449001387,-12,-4,0,0,-4,0,0,0,0,0,0,-2,2,0,0,0,0,-5,0,-3,-5,-8,0,-6,-8,0.037219730941704,-0.0436692506459948,-0.142375028839499,-0.348678601875533,-0.0916230366492146,0.894736842105263,-0.983525535420099,"Stabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","150/150","K:Q",2.9697959800773,4.2195571364394e-06,0.645570763650269,4.60026405670093,6.18542852926305,85.5881348249979,1.28976636711505,1.66262776179573e-07,6.77920497212353,5.25121653678864,107.844057222035,8.72260296739213e-10,"lineage2","dr_mutations_pyrazinamide","ARG",0,"ERR2516844","ERR2516844","lineage2.2.1","gb","UK","pnca_p.lys96arg","A","E","LYS","KA96","pnca_complex.pdb"
|
|
"K96R","L4","PZA","K","K96",96,"R",NA,"MDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",3.977,0.083,-0.169,-0.740521,-2.045,-0.35,85,91,-1.194,9,9,8,0.0338983050847457,"strand",-1.86666666666667,5.96,0.0010780508840017,19.4879594423321,19.4879432617414,19.4791388432651,37.591449001387,-12,-4,0,0,-4,0,0,0,0,0,0,-2,2,0,0,0,0,-5,0,-3,-5,-8,0,-6,-8,0.037219730941704,-0.0436692506459948,-0.142375028839499,-0.348678601875533,-0.0916230366492146,0.894736842105263,-0.983525535420099,"Stabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","150/150","K:Q",2.9697959800773,4.2195571364394e-06,0.645570763650269,4.60026405670093,6.18542852926305,85.5881348249979,1.28976636711505,1.66262776179573e-07,6.77920497212353,5.25121653678864,107.844057222035,8.72260296739213e-10,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERR779918","ERR779918","lineage4","pe","","pnca_p.lys96arg","A","E","LYS","KA96","pnca_complex.pdb"
|
|
"K96R","L4","PZA","K","K96",96,"R",NA,"MDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",3.977,0.083,-0.169,-0.740521,-2.045,-0.35,85,91,-1.194,9,9,8,0.0338983050847457,"strand",-1.86666666666667,5.96,0.0010780508840017,19.4879594423321,19.4879432617414,19.4791388432651,37.591449001387,-12,-4,0,0,-4,0,0,0,0,0,0,-2,2,0,0,0,0,-5,0,-3,-5,-8,0,-6,-8,0.037219730941704,-0.0436692506459948,-0.142375028839499,-0.348678601875533,-0.0916230366492146,0.894736842105263,-0.983525535420099,"Stabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","150/150","K:Q",2.9697959800773,4.2195571364394e-06,0.645570763650269,4.60026405670093,6.18542852926305,85.5881348249979,1.28976636711505,1.66262776179573e-07,6.77920497212353,5.25121653678864,107.844057222035,8.72260296739213e-10,"lineage4","dr_mutations_pyrazinamide","ARG",0,"SAMN02053777","SRR833081_SRR833120_SRR833101","lineage4.3.2.1","za","South Africa","pnca_p.lys96arg","A","E","LYS","KA96","pnca_complex.pdb"
|
|
"K96R","L4","PZA","K","K96",96,"R",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",3.977,0.083,-0.169,-0.740521,-2.045,-0.35,85,91,-1.194,9,9,8,0.0338983050847457,"strand",-1.86666666666667,5.96,0.0010780508840017,19.4879594423321,19.4879432617414,19.4791388432651,37.591449001387,-12,-4,0,0,-4,0,0,0,0,0,0,-2,2,0,0,0,0,-5,0,-3,-5,-8,0,-6,-8,0.037219730941704,-0.0436692506459948,-0.142375028839499,-0.348678601875533,-0.0916230366492146,0.894736842105263,-0.983525535420099,"Stabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","150/150","K:Q",2.9697959800773,4.2195571364394e-06,0.645570763650269,4.60026405670093,6.18542852926305,85.5881348249979,1.28976636711505,1.66262776179573e-07,6.77920497212353,5.25121653678864,107.844057222035,8.72260296739213e-10,"lineage4","dr_mutations_pyrazinamide","ARG",0,"SRR671751,BGI_FJ05132","SRR671751","lineage4.5","cn","China","pnca_p.lys96arg","A","E","LYS","KA96","pnca_complex.pdb"
|
|
"K96R","L4","PZA","K","K96",96,"R",1,"MDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",3.977,0.083,-0.169,-0.740521,-2.045,-0.35,85,91,-1.194,9,9,8,0.0338983050847457,"strand",-1.86666666666667,5.96,0.0010780508840017,19.4879594423321,19.4879432617414,19.4791388432651,37.591449001387,-12,-4,0,0,-4,0,0,0,0,0,0,-2,2,0,0,0,0,-5,0,-3,-5,-8,0,-6,-8,0.037219730941704,-0.0436692506459948,-0.142375028839499,-0.348678601875533,-0.0916230366492146,0.894736842105263,-0.983525535420099,"Stabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","150/150","K:Q",2.9697959800773,4.2195571364394e-06,0.645570763650269,4.60026405670093,6.18542852926305,85.5881348249979,1.28976636711505,1.66262776179573e-07,6.77920497212353,5.25121653678864,107.844057222035,8.72260296739213e-10,"lineage4","dr_mutations_pyrazinamide","ARG",0,"SAMN02053757","SRR833000_SRR832978","lineage4.3.2.1","za","South Africa","pnca_p.lys96arg","A","E","LYS","KA96","pnca_complex.pdb"
|
|
"K96R","L3","PZA","K","K96",96,"R",1,"MDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",3.977,0.083,-0.169,-0.740521,-2.045,-0.35,85,91,-1.194,9,9,8,0.0338983050847457,"strand",-1.86666666666667,5.96,0.0010780508840017,19.4879594423321,19.4879432617414,19.4791388432651,37.591449001387,-12,-4,0,0,-4,0,0,0,0,0,0,-2,2,0,0,0,0,-5,0,-3,-5,-8,0,-6,-8,0.037219730941704,-0.0436692506459948,-0.142375028839499,-0.348678601875533,-0.0916230366492146,0.894736842105263,-0.983525535420099,"Stabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","150/150","K:Q",2.9697959800773,4.2195571364394e-06,0.645570763650269,4.60026405670093,6.18542852926305,85.5881348249979,1.28976636711505,1.66262776179573e-07,6.77920497212353,5.25121653678864,107.844057222035,8.72260296739213e-10,"lineage3","dr_mutations_pyrazinamide","ARG",0,"ERR2510433","ERR2510433","lineage3","pk","Pakistan","pnca_p.lys96arg","A","E","LYS","KA96","pnca_complex.pdb"
|
|
"K96R","L4","PZA","K","K96",96,"R",NA,"MDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",3.977,0.083,-0.169,-0.740521,-2.045,-0.35,85,91,-1.194,9,9,8,0.0338983050847457,"strand",-1.86666666666667,5.96,0.0010780508840017,19.4879594423321,19.4879432617414,19.4791388432651,37.591449001387,-12,-4,0,0,-4,0,0,0,0,0,0,-2,2,0,0,0,0,-5,0,-3,-5,-8,0,-6,-8,0.037219730941704,-0.0436692506459948,-0.142375028839499,-0.348678601875533,-0.0916230366492146,0.894736842105263,-0.983525535420099,"Stabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","150/150","K:Q",2.9697959800773,4.2195571364394e-06,0.645570763650269,4.60026405670093,6.18542852926305,85.5881348249979,1.28976636711505,1.66262776179573e-07,6.77920497212353,5.25121653678864,107.844057222035,8.72260296739213e-10,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERR1193888","ERR1193888","lineage4.3.2.1","sz","Swaziland","pnca_p.lys96arg","A","E","LYS","KA96","pnca_complex.pdb"
|
|
"K96R","L4","PZA","K","K96",96,"R",0,"Pre-MDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",3.977,0.083,-0.169,-0.740521,-2.045,-0.35,85,91,-1.194,9,9,8,0.0338983050847457,"strand",-1.86666666666667,5.96,0.0010780508840017,19.4879594423321,19.4879432617414,19.4791388432651,37.591449001387,-12,-4,0,0,-4,0,0,0,0,0,0,-2,2,0,0,0,0,-5,0,-3,-5,-8,0,-6,-8,0.037219730941704,-0.0436692506459948,-0.142375028839499,-0.348678601875533,-0.0916230366492146,0.894736842105263,-0.983525535420099,"Stabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","150/150","K:Q",2.9697959800773,4.2195571364394e-06,0.645570763650269,4.60026405670093,6.18542852926305,85.5881348249979,1.28976636711505,1.66262776179573e-07,6.77920497212353,5.25121653678864,107.844057222035,8.72260296739213e-10,"lineage4","dr_mutations_pyrazinamide","ARG",0,"SAMN03648990,SRR2101743","SRR2101743","lineage4.3.2.1","","","pnca_p.lys96arg","A","E","LYS","KA96","pnca_complex.pdb"
|
|
"K96R","L2","PZA","K","K96",96,"R",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",3.977,0.083,-0.169,-0.740521,-2.045,-0.35,85,91,-1.194,9,9,8,0.0338983050847457,"strand",-1.86666666666667,5.96,0.0010780508840017,19.4879594423321,19.4879432617414,19.4791388432651,37.591449001387,-12,-4,0,0,-4,0,0,0,0,0,0,-2,2,0,0,0,0,-5,0,-3,-5,-8,0,-6,-8,0.037219730941704,-0.0436692506459948,-0.142375028839499,-0.348678601875533,-0.0916230366492146,0.894736842105263,-0.983525535420099,"Stabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","150/150","K:Q",2.9697959800773,4.2195571364394e-06,0.645570763650269,4.60026405670093,6.18542852926305,85.5881348249979,1.28976636711505,1.66262776179573e-07,6.77920497212353,5.25121653678864,107.844057222035,8.72260296739213e-10,"lineage2","dr_mutations_pyrazinamide","ARG",0,"ERR234629","ERR234629","lineage2.2.1","ru","Russia","pnca_p.lys96arg","A","E","LYS","KA96","pnca_complex.pdb"
|
|
"K96R","L2","PZA","K","K96",96,"R",1,"Pre-XDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",3.977,0.083,-0.169,-0.740521,-2.045,-0.35,85,91,-1.194,9,9,8,0.0338983050847457,"strand",-1.86666666666667,5.96,0.0010780508840017,19.4879594423321,19.4879432617414,19.4791388432651,37.591449001387,-12,-4,0,0,-4,0,0,0,0,0,0,-2,2,0,0,0,0,-5,0,-3,-5,-8,0,-6,-8,0.037219730941704,-0.0436692506459948,-0.142375028839499,-0.348678601875533,-0.0916230366492146,0.894736842105263,-0.983525535420099,"Stabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","150/150","K:Q",2.9697959800773,4.2195571364394e-06,0.645570763650269,4.60026405670093,6.18542852926305,85.5881348249979,1.28976636711505,1.66262776179573e-07,6.77920497212353,5.25121653678864,107.844057222035,8.72260296739213e-10,"lineage2","dr_mutations_pyrazinamide","ARG",0,"SAMN10961368","SRR8651602","lineage2.2.1","cn","China:Wenzhou","pnca_p.lys96arg","A","E","LYS","KA96","pnca_complex.pdb"
|
|
"K96R","L4","PZA","K","K96",96,"R",1,"MDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",3.977,0.083,-0.169,-0.740521,-2.045,-0.35,85,91,-1.194,9,9,8,0.0338983050847457,"strand",-1.86666666666667,5.96,0.0010780508840017,19.4879594423321,19.4879432617414,19.4791388432651,37.591449001387,-12,-4,0,0,-4,0,0,0,0,0,0,-2,2,0,0,0,0,-5,0,-3,-5,-8,0,-6,-8,0.037219730941704,-0.0436692506459948,-0.142375028839499,-0.348678601875533,-0.0916230366492146,0.894736842105263,-0.983525535420099,"Stabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","150/150","K:Q",2.9697959800773,4.2195571364394e-06,0.645570763650269,4.60026405670093,6.18542852926305,85.5881348249979,1.28976636711505,1.66262776179573e-07,6.77920497212353,5.25121653678864,107.844057222035,8.72260296739213e-10,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERR552789","ERR552789","lineage4.3.2.1","sz","Swaziland","pnca_p.lys96arg","A","E","LYS","KA96","pnca_complex.pdb"
|
|
"K96R","L4","PZA","K","K96",96,"R",NA,"MDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",3.977,0.083,-0.169,-0.740521,-2.045,-0.35,85,91,-1.194,9,9,8,0.0338983050847457,"strand",-1.86666666666667,5.96,0.0010780508840017,19.4879594423321,19.4879432617414,19.4791388432651,37.591449001387,-12,-4,0,0,-4,0,0,0,0,0,0,-2,2,0,0,0,0,-5,0,-3,-5,-8,0,-6,-8,0.037219730941704,-0.0436692506459948,-0.142375028839499,-0.348678601875533,-0.0916230366492146,0.894736842105263,-0.983525535420099,"Stabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","150/150","K:Q",2.9697959800773,4.2195571364394e-06,0.645570763650269,4.60026405670093,6.18542852926305,85.5881348249979,1.28976636711505,1.66262776179573e-07,6.77920497212353,5.25121653678864,107.844057222035,8.72260296739213e-10,"lineage4","dr_mutations_pyrazinamide","ARG",0,"2078","ERR2433007","lineage4.3.4.2.1","br","Momazbique","pnca_p.lys96arg","A","E","LYS","KA96","pnca_complex.pdb"
|
|
"K96R","L2","PZA","K","K96",96,"R",0,"Pre-XDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",3.977,0.083,-0.169,-0.740521,-2.045,-0.35,85,91,-1.194,9,9,8,0.0338983050847457,"strand",-1.86666666666667,5.96,0.0010780508840017,19.4879594423321,19.4879432617414,19.4791388432651,37.591449001387,-12,-4,0,0,-4,0,0,0,0,0,0,-2,2,0,0,0,0,-5,0,-3,-5,-8,0,-6,-8,0.037219730941704,-0.0436692506459948,-0.142375028839499,-0.348678601875533,-0.0916230366492146,0.894736842105263,-0.983525535420099,"Stabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","150/150","K:Q",2.9697959800773,4.2195571364394e-06,0.645570763650269,4.60026405670093,6.18542852926305,85.5881348249979,1.28976636711505,1.66262776179573e-07,6.77920497212353,5.25121653678864,107.844057222035,8.72260296739213e-10,"lineage2","dr_mutations_pyrazinamide","ARG",0,"ERR2517089","ERR2517089","lineage2.2.1","gb","UK","pnca_p.lys96arg","A","E","LYS","KA96","pnca_complex.pdb"
|
|
"K96R","L2","PZA","K","K96",96,"R",1,"Pre-XDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",3.977,0.083,-0.169,-0.740521,-2.045,-0.35,85,91,-1.194,9,9,8,0.0338983050847457,"strand",-1.86666666666667,5.96,0.0010780508840017,19.4879594423321,19.4879432617414,19.4791388432651,37.591449001387,-12,-4,0,0,-4,0,0,0,0,0,0,-2,2,0,0,0,0,-5,0,-3,-5,-8,0,-6,-8,0.037219730941704,-0.0436692506459948,-0.142375028839499,-0.348678601875533,-0.0916230366492146,0.894736842105263,-0.983525535420099,"Stabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","150/150","K:Q",2.9697959800773,4.2195571364394e-06,0.645570763650269,4.60026405670093,6.18542852926305,85.5881348249979,1.28976636711505,1.66262776179573e-07,6.77920497212353,5.25121653678864,107.844057222035,8.72260296739213e-10,"lineage2","dr_mutations_pyrazinamide","ARG",0,"ERR2516805","ERR2516805","lineage2.2.1","gb","UK","pnca_p.lys96arg","A","E","LYS","KA96","pnca_complex.pdb"
|
|
"K96R","L2","PZA","K","K96",96,"R",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",3.977,0.083,-0.169,-0.740521,-2.045,-0.35,85,91,-1.194,9,9,8,0.0338983050847457,"strand",-1.86666666666667,5.96,0.0010780508840017,19.4879594423321,19.4879432617414,19.4791388432651,37.591449001387,-12,-4,0,0,-4,0,0,0,0,0,0,-2,2,0,0,0,0,-5,0,-3,-5,-8,0,-6,-8,0.037219730941704,-0.0436692506459948,-0.142375028839499,-0.348678601875533,-0.0916230366492146,0.894736842105263,-0.983525535420099,"Stabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","150/150","K:Q",2.9697959800773,4.2195571364394e-06,0.645570763650269,4.60026405670093,6.18542852926305,85.5881348249979,1.28976636711505,1.66262776179573e-07,6.77920497212353,5.25121653678864,107.844057222035,8.72260296739213e-10,"lineage2","dr_mutations_pyrazinamide","ARG",0,"SRS796967","SRR1723454","lineage2.2.1","cn","China:Liaoning","pnca_p.lys96arg","A","E","LYS","KA96","pnca_complex.pdb"
|
|
"K96R","L2","PZA","K","K96",96,"R",1,"XDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",3.977,0.083,-0.169,-0.740521,-2.045,-0.35,85,91,-1.194,9,9,8,0.0338983050847457,"strand",-1.86666666666667,5.96,0.0010780508840017,19.4879594423321,19.4879432617414,19.4791388432651,37.591449001387,-12,-4,0,0,-4,0,0,0,0,0,0,-2,2,0,0,0,0,-5,0,-3,-5,-8,0,-6,-8,0.037219730941704,-0.0436692506459948,-0.142375028839499,-0.348678601875533,-0.0916230366492146,0.894736842105263,-0.983525535420099,"Stabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","150/150","K:Q",2.9697959800773,4.2195571364394e-06,0.645570763650269,4.60026405670093,6.18542852926305,85.5881348249979,1.28976636711505,1.66262776179573e-07,6.77920497212353,5.25121653678864,107.844057222035,8.72260296739213e-10,"lineage2","dr_mutations_pyrazinamide","ARG",0,"ERR133951,0824X-sc-2012-02-09T18:57:16Z-1355284","ERR133951","lineage2.2.1","ru","Russia,Samara","pnca_p.lys96arg","A","E","LYS","KA96","pnca_complex.pdb"
|
|
"K96R","L3","PZA","K","K96",96,"R",1,"MDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",3.977,0.083,-0.169,-0.740521,-2.045,-0.35,85,91,-1.194,9,9,8,0.0338983050847457,"strand",-1.86666666666667,5.96,0.0010780508840017,19.4879594423321,19.4879432617414,19.4791388432651,37.591449001387,-12,-4,0,0,-4,0,0,0,0,0,0,-2,2,0,0,0,0,-5,0,-3,-5,-8,0,-6,-8,0.037219730941704,-0.0436692506459948,-0.142375028839499,-0.348678601875533,-0.0916230366492146,0.894736842105263,-0.983525535420099,"Stabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","150/150","K:Q",2.9697959800773,4.2195571364394e-06,0.645570763650269,4.60026405670093,6.18542852926305,85.5881348249979,1.28976636711505,1.66262776179573e-07,6.77920497212353,5.25121653678864,107.844057222035,8.72260296739213e-10,"lineage3","dr_mutations_pyrazinamide","ARG",0,"ERR2510502","ERR2510502","lineage3","pk","Pakistan","pnca_p.lys96arg","A","E","LYS","KA96","pnca_complex.pdb"
|
|
"K96R","L2","PZA","K","K96",96,"R",1,"Pre-XDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",3.977,0.083,-0.169,-0.740521,-2.045,-0.35,85,91,-1.194,9,9,8,0.0338983050847457,"strand",-1.86666666666667,5.96,0.0010780508840017,19.4879594423321,19.4879432617414,19.4791388432651,37.591449001387,-12,-4,0,0,-4,0,0,0,0,0,0,-2,2,0,0,0,0,-5,0,-3,-5,-8,0,-6,-8,0.037219730941704,-0.0436692506459948,-0.142375028839499,-0.348678601875533,-0.0916230366492146,0.894736842105263,-0.983525535420099,"Stabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","150/150","K:Q",2.9697959800773,4.2195571364394e-06,0.645570763650269,4.60026405670093,6.18542852926305,85.5881348249979,1.28976636711505,1.66262776179573e-07,6.77920497212353,5.25121653678864,107.844057222035,8.72260296739213e-10,"lineage2","dr_mutations_pyrazinamide","ARG",0,"ERR2516982","ERR2516982","lineage2.2.1","gb","UK","pnca_p.lys96arg","A","E","LYS","KA96","pnca_complex.pdb"
|
|
"K96R","L4","PZA","K","K96",96,"R",NA,"Other","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",3.977,0.083,-0.169,-0.740521,-2.045,-0.35,85,91,-1.194,9,9,8,0.0338983050847457,"strand",-1.86666666666667,5.96,0.0010780508840017,19.4879594423321,19.4879432617414,19.4791388432651,37.591449001387,-12,-4,0,0,-4,0,0,0,0,0,0,-2,2,0,0,0,0,-5,0,-3,-5,-8,0,-6,-8,0.037219730941704,-0.0436692506459948,-0.142375028839499,-0.348678601875533,-0.0916230366492146,0.894736842105263,-0.983525535420099,"Stabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","150/150","K:Q",2.9697959800773,4.2195571364394e-06,0.645570763650269,4.60026405670093,6.18542852926305,85.5881348249979,1.28976636711505,1.66262776179573e-07,6.77920497212353,5.25121653678864,107.844057222035,8.72260296739213e-10,"lineage4","dr_mutations_pyrazinamide","ARG",0,"SAMN07658746","SRR6045621","lineage4.1.1.3","gb","UK","pnca_p.lys96arg","A","E","LYS","KA96","pnca_complex.pdb"
|
|
"K96R","L2","PZA","K","K96",96,"R",1,"MDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",3.977,0.083,-0.169,-0.740521,-2.045,-0.35,85,91,-1.194,9,9,8,0.0338983050847457,"strand",-1.86666666666667,5.96,0.0010780508840017,19.4879594423321,19.4879432617414,19.4791388432651,37.591449001387,-12,-4,0,0,-4,0,0,0,0,0,0,-2,2,0,0,0,0,-5,0,-3,-5,-8,0,-6,-8,0.037219730941704,-0.0436692506459948,-0.142375028839499,-0.348678601875533,-0.0916230366492146,0.894736842105263,-0.983525535420099,"Stabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","150/150","K:Q",2.9697959800773,4.2195571364394e-06,0.645570763650269,4.60026405670093,6.18542852926305,85.5881348249979,1.28976636711505,1.66262776179573e-07,6.77920497212353,5.25121653678864,107.844057222035,8.72260296739213e-10,"lineage2","dr_mutations_pyrazinamide","ARG",0,"0443H-sc-2011-09-07T13:19:18Z-1276474,ERR067627","ERR067627","lineage2.2.1","ru","Russia,Samara","pnca_p.lys96arg","A","E","LYS","KA96","pnca_complex.pdb"
|
|
"K96R","L4","PZA","K","K96",96,"R",NA,"Other","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",3.977,0.083,-0.169,-0.740521,-2.045,-0.35,85,91,-1.194,9,9,8,0.0338983050847457,"strand",-1.86666666666667,5.96,0.0010780508840017,19.4879594423321,19.4879432617414,19.4791388432651,37.591449001387,-12,-4,0,0,-4,0,0,0,0,0,0,-2,2,0,0,0,0,-5,0,-3,-5,-8,0,-6,-8,0.037219730941704,-0.0436692506459948,-0.142375028839499,-0.348678601875533,-0.0916230366492146,0.894736842105263,-0.983525535420099,"Stabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","150/150","K:Q",2.9697959800773,4.2195571364394e-06,0.645570763650269,4.60026405670093,6.18542852926305,85.5881348249979,1.28976636711505,1.66262776179573e-07,6.77920497212353,5.25121653678864,107.844057222035,8.72260296739213e-10,"lineage4","dr_mutations_pyrazinamide","ARG",0,"SAMN07659679","SRR6046374","lineage4.1.1.3","gb","UK","pnca_p.lys96arg","A","E","LYS","KA96","pnca_complex.pdb"
|
|
"K96R","L4","PZA","K","K96",96,"R",1,"MDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",3.977,0.083,-0.169,-0.740521,-2.045,-0.35,85,91,-1.194,9,9,8,0.0338983050847457,"strand",-1.86666666666667,5.96,0.0010780508840017,19.4879594423321,19.4879432617414,19.4791388432651,37.591449001387,-12,-4,0,0,-4,0,0,0,0,0,0,-2,2,0,0,0,0,-5,0,-3,-5,-8,0,-6,-8,0.037219730941704,-0.0436692506459948,-0.142375028839499,-0.348678601875533,-0.0916230366492146,0.894736842105263,-0.983525535420099,"Stabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","150/150","K:Q",2.9697959800773,4.2195571364394e-06,0.645570763650269,4.60026405670093,6.18542852926305,85.5881348249979,1.28976636711505,1.66262776179573e-07,6.77920497212353,5.25121653678864,107.844057222035,8.72260296739213e-10,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERR2516593","ERR2516593","lineage4.1.2.1","nl","Netherlands","pnca_p.lys96arg","A","E","LYS","KA96","pnca_complex.pdb"
|
|
"K96R","L2","PZA","K","K96",96,"R",1,"Pre-XDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",3.977,0.083,-0.169,-0.740521,-2.045,-0.35,85,91,-1.194,9,9,8,0.0338983050847457,"strand",-1.86666666666667,5.96,0.0010780508840017,19.4879594423321,19.4879432617414,19.4791388432651,37.591449001387,-12,-4,0,0,-4,0,0,0,0,0,0,-2,2,0,0,0,0,-5,0,-3,-5,-8,0,-6,-8,0.037219730941704,-0.0436692506459948,-0.142375028839499,-0.348678601875533,-0.0916230366492146,0.894736842105263,-0.983525535420099,"Stabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","150/150","K:Q",2.9697959800773,4.2195571364394e-06,0.645570763650269,4.60026405670093,6.18542852926305,85.5881348249979,1.28976636711505,1.66262776179573e-07,6.77920497212353,5.25121653678864,107.844057222035,8.72260296739213e-10,"lineage2","dr_mutations_pyrazinamide","ARG",0,"MDR_6145","SRR6824356","lineage2.2.1","cn","China: Liaoyang City, Liaoning Province","pnca_p.lys96arg","A","E","LYS","KA96","pnca_complex.pdb"
|
|
"K96R","L1","PZA","K","K96",96,"R",NA,"MDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",3.977,0.083,-0.169,-0.740521,-2.045,-0.35,85,91,-1.194,9,9,8,0.0338983050847457,"strand",-1.86666666666667,5.96,0.0010780508840017,19.4879594423321,19.4879432617414,19.4791388432651,37.591449001387,-12,-4,0,0,-4,0,0,0,0,0,0,-2,2,0,0,0,0,-5,0,-3,-5,-8,0,-6,-8,0.037219730941704,-0.0436692506459948,-0.142375028839499,-0.348678601875533,-0.0916230366492146,0.894736842105263,-0.983525535420099,"Stabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","150/150","K:Q",2.9697959800773,4.2195571364394e-06,0.645570763650269,4.60026405670093,6.18542852926305,85.5881348249979,1.28976636711505,1.66262776179573e-07,6.77920497212353,5.25121653678864,107.844057222035,8.72260296739213e-10,"lineage1","dr_mutations_pyrazinamide","ARG",0,"DRR184885","DRR184885","lineage1.1.1.1","vn","Vietnam","pnca_p.lys96arg","A","E","LYS","KA96","pnca_complex.pdb"
|
|
"K96R","L2","PZA","K","K96",96,"R",1,"Pre-XDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",3.977,0.083,-0.169,-0.740521,-2.045,-0.35,85,91,-1.194,9,9,8,0.0338983050847457,"strand",-1.86666666666667,5.96,0.0010780508840017,19.4879594423321,19.4879432617414,19.4791388432651,37.591449001387,-12,-4,0,0,-4,0,0,0,0,0,0,-2,2,0,0,0,0,-5,0,-3,-5,-8,0,-6,-8,0.037219730941704,-0.0436692506459948,-0.142375028839499,-0.348678601875533,-0.0916230366492146,0.894736842105263,-0.983525535420099,"Stabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","150/150","K:Q",2.9697959800773,4.2195571364394e-06,0.645570763650269,4.60026405670093,6.18542852926305,85.5881348249979,1.28976636711505,1.66262776179573e-07,6.77920497212353,5.25121653678864,107.844057222035,8.72260296739213e-10,"lineage2","dr_mutations_pyrazinamide","ARG",0,"ERR2516968","ERR2516968","lineage2.2.1","gb","UK","pnca_p.lys96arg","A","E","LYS","KA96","pnca_complex.pdb"
|
|
"K96R","L4","PZA","K","K96",96,"R",NA,"MDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",3.977,0.083,-0.169,-0.740521,-2.045,-0.35,85,91,-1.194,9,9,8,0.0338983050847457,"strand",-1.86666666666667,5.96,0.0010780508840017,19.4879594423321,19.4879432617414,19.4791388432651,37.591449001387,-12,-4,0,0,-4,0,0,0,0,0,0,-2,2,0,0,0,0,-5,0,-3,-5,-8,0,-6,-8,0.037219730941704,-0.0436692506459948,-0.142375028839499,-0.348678601875533,-0.0916230366492146,0.894736842105263,-0.983525535420099,"Stabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","150/150","K:Q",2.9697959800773,4.2195571364394e-06,0.645570763650269,4.60026405670093,6.18542852926305,85.5881348249979,1.28976636711505,1.66262776179573e-07,6.77920497212353,5.25121653678864,107.844057222035,8.72260296739213e-10,"lineage4","dr_mutations_pyrazinamide","ARG",0,"751","ERR2433003","lineage4.3.4.2.1","br","Momazbique","pnca_p.lys96arg","A","E","LYS","KA96","pnca_complex.pdb"
|
|
"K96R","L1","PZA","K","K96",96,"R",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",3.977,0.083,-0.169,-0.740521,-2.045,-0.35,85,91,-1.194,9,9,8,0.0338983050847457,"strand",-1.86666666666667,5.96,0.0010780508840017,19.4879594423321,19.4879432617414,19.4791388432651,37.591449001387,-12,-4,0,0,-4,0,0,0,0,0,0,-2,2,0,0,0,0,-5,0,-3,-5,-8,0,-6,-8,0.037219730941704,-0.0436692506459948,-0.142375028839499,-0.348678601875533,-0.0916230366492146,0.894736842105263,-0.983525535420099,"Stabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","150/150","K:Q",2.9697959800773,4.2195571364394e-06,0.645570763650269,4.60026405670093,6.18542852926305,85.5881348249979,1.28976636711505,1.66262776179573e-07,6.77920497212353,5.25121653678864,107.844057222035,8.72260296739213e-10,"lineage1","dr_mutations_pyrazinamide","ARG",0,"SRR5709758,SAMN07236272","SRR5709758","lineage1.1.1","th","Thailand","pnca_p.lys96arg","A","E","LYS","KA96","pnca_complex.pdb"
|
|
"K96T","L2","PZA","K","K96",96,"T",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","basic","neutral","pos","polar",3.977,-0.57,-0.86,3.53764,-0.932,-0.61,85,91,-1.194,9,9,8,0.0338983050847457,"strand",-1.86666666666667,5.96,0.0009343107661348,58.4740177439797,58.473941530631,58.4547574725378,46.7514830195167,72,8,0,0,8,0,0,0,0,4,0,0,4,0,0,0,0,0,0,0,0,8,0,6,4,-0.144376899696049,-0.222222222222222,0.128848549304701,-0.158908780903666,-0.159685863874345,0.894736842105263,-0.983525535420099,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","150/150","K:Q",4.06858121107736,9.193364498612e-05,1.04030498364652,3.91095041842056,11.5166635599539,1065.61332397744,1.76696293519342,6.68324361543955e-09,8.17501270782547,8.64086529870195,2465.74647273772,8.05839318437163e-12,"lineage2","dr_mutations_pyrazinamide","THR",0,"SAMN02360569","SRR1048963_SRR1013580_SRR1013579_SRR1048962","lineage2.2.1","kr","South Korea","pnca_p.lys96thr","A","E","LYS","KA96","pnca_complex.pdb"
|
|
"K96T","L2","PZA","K","K96",96,"T",1,"XDR","DM","hydrophobic","hydrophobic","basic","neutral","pos","polar",3.977,-0.57,-0.86,3.53764,-0.932,-0.61,85,91,-1.194,9,9,8,0.0338983050847457,"strand",-1.86666666666667,5.96,0.0009343107661348,58.4740177439797,58.473941530631,58.4547574725378,46.7514830195167,72,8,0,0,8,0,0,0,0,4,0,0,4,0,0,0,0,0,0,0,0,8,0,6,4,-0.144376899696049,-0.222222222222222,0.128848549304701,-0.158908780903666,-0.159685863874345,0.894736842105263,-0.983525535420099,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","150/150","K:Q",4.06858121107736,9.193364498612e-05,1.04030498364652,3.91095041842056,11.5166635599539,1065.61332397744,1.76696293519342,6.68324361543955e-09,8.17501270782547,8.64086529870195,2465.74647273772,8.05839318437163e-12,"lineage2","dr_mutations_pyrazinamide","THR",0,"ERR2516364","ERR2516364","lineage2.2.1","be","Belgium","pnca_p.lys96thr","A","E","LYS","KA96","pnca_complex.pdb"
|
|
"K96T","L3","PZA","K","K96",96,"T",1,"Other","DM","hydrophobic","hydrophobic","basic","neutral","pos","polar",3.977,-0.57,-0.86,3.53764,-0.932,-0.61,85,91,-1.194,9,9,8,0.0338983050847457,"strand",-1.86666666666667,5.96,0.0009343107661348,58.4740177439797,58.473941530631,58.4547574725378,46.7514830195167,72,8,0,0,8,0,0,0,0,4,0,0,4,0,0,0,0,0,0,0,0,8,0,6,4,-0.144376899696049,-0.222222222222222,0.128848549304701,-0.158908780903666,-0.159685863874345,0.894736842105263,-0.983525535420099,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","150/150","K:Q",4.06858121107736,9.193364498612e-05,1.04030498364652,3.91095041842056,11.5166635599539,1065.61332397744,1.76696293519342,6.68324361543955e-09,8.17501270782547,8.64086529870195,2465.74647273772,8.05839318437163e-12,"lineage3","dr_mutations_pyrazinamide","THR",0,"ERR2513720","ERR2513720","lineage3","gb","UK","pnca_p.lys96thr","A","E","LYS","KA96","pnca_complex.pdb"
|
|
"K96T","L2","PZA","K","K96",96,"T",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","basic","neutral","pos","polar",3.977,-0.57,-0.86,3.53764,-0.932,-0.61,85,91,-1.194,9,9,8,0.0338983050847457,"strand",-1.86666666666667,5.96,0.0009343107661348,58.4740177439797,58.473941530631,58.4547574725378,46.7514830195167,72,8,0,0,8,0,0,0,0,4,0,0,4,0,0,0,0,0,0,0,0,8,0,6,4,-0.144376899696049,-0.222222222222222,0.128848549304701,-0.158908780903666,-0.159685863874345,0.894736842105263,-0.983525535420099,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","150/150","K:Q",4.06858121107736,9.193364498612e-05,1.04030498364652,3.91095041842056,11.5166635599539,1065.61332397744,1.76696293519342,6.68324361543955e-09,8.17501270782547,8.64086529870195,2465.74647273772,8.05839318437163e-12,"lineage2","dr_mutations_pyrazinamide","THR",0,"SRR5709795,SAMN07236264","SRR5709795","lineage2.2.1","th","Thailand","pnca_p.lys96thr","A","E","LYS","KA96","pnca_complex.pdb"
|
|
"K96T","L4","PZA","K","K96",96,"T",NA,"MDR","DM","hydrophobic","hydrophobic","basic","neutral","pos","polar",3.977,-0.57,-0.86,3.53764,-0.932,-0.61,85,91,-1.194,9,9,8,0.0338983050847457,"strand",-1.86666666666667,5.96,0.0009343107661348,58.4740177439797,58.473941530631,58.4547574725378,46.7514830195167,72,8,0,0,8,0,0,0,0,4,0,0,4,0,0,0,0,0,0,0,0,8,0,6,4,-0.144376899696049,-0.222222222222222,0.128848549304701,-0.158908780903666,-0.159685863874345,0.894736842105263,-0.983525535420099,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","150/150","K:Q",4.06858121107736,9.193364498612e-05,1.04030498364652,3.91095041842056,11.5166635599539,1065.61332397744,1.76696293519342,6.68324361543955e-09,8.17501270782547,8.64086529870195,2465.74647273772,8.05839318437163e-12,"lineage4","dr_mutations_pyrazinamide","THR",0,"ERR2706956","ERR2706956","lineage4.3.2","cd","Democratic Republic of Congo","pnca_p.lys96thr","A","E","LYS","KA96","pnca_complex.pdb"
|
|
"K96T","L4","PZA","K","K96",96,"T",NA,"MDR","DM","hydrophobic","hydrophobic","basic","neutral","pos","polar",3.977,-0.57,-0.86,3.53764,-0.932,-0.61,85,91,-1.194,9,9,8,0.0338983050847457,"strand",-1.86666666666667,5.96,0.0009343107661348,58.4740177439797,58.473941530631,58.4547574725378,46.7514830195167,72,8,0,0,8,0,0,0,0,4,0,0,4,0,0,0,0,0,0,0,0,8,0,6,4,-0.144376899696049,-0.222222222222222,0.128848549304701,-0.158908780903666,-0.159685863874345,0.894736842105263,-0.983525535420099,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","150/150","K:Q",4.06858121107736,9.193364498612e-05,1.04030498364652,3.91095041842056,11.5166635599539,1065.61332397744,1.76696293519342,6.68324361543955e-09,8.17501270782547,8.64086529870195,2465.74647273772,8.05839318437163e-12,"lineage4","dr_mutations_pyrazinamide","THR",0,"ERR2706958","ERR2706958","lineage4.3.2","cd","Democratic Republic of Congo","pnca_p.lys96thr","A","E","LYS","KA96","pnca_complex.pdb"
|
|
"K96T","L4","PZA","K","K96",96,"T",1,"Pre-XDR","DM","hydrophobic","hydrophobic","basic","neutral","pos","polar",3.977,-0.57,-0.86,3.53764,-0.932,-0.61,85,91,-1.194,9,9,8,0.0338983050847457,"strand",-1.86666666666667,5.96,0.0009343107661348,58.4740177439797,58.473941530631,58.4547574725378,46.7514830195167,72,8,0,0,8,0,0,0,0,4,0,0,4,0,0,0,0,0,0,0,0,8,0,6,4,-0.144376899696049,-0.222222222222222,0.128848549304701,-0.158908780903666,-0.159685863874345,0.894736842105263,-0.983525535420099,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","150/150","K:Q",4.06858121107736,9.193364498612e-05,1.04030498364652,3.91095041842056,11.5166635599539,1065.61332397744,1.76696293519342,6.68324361543955e-09,8.17501270782547,8.64086529870195,2465.74647273772,8.05839318437163e-12,"lineage4","dr_mutations_pyrazinamide","THR",0,"ERR2517045","ERR2517045","lineage4.4.1.1","gb","UK","pnca_p.lys96thr","A","E","LYS","KA96","pnca_complex.pdb"
|
|
"K96T","L4","PZA","K","K96",96,"T",NA,"MDR","DM","hydrophobic","hydrophobic","basic","neutral","pos","polar",3.977,-0.57,-0.86,3.53764,-0.932,-0.61,85,91,-1.194,9,9,8,0.0338983050847457,"strand",-1.86666666666667,5.96,0.0009343107661348,58.4740177439797,58.473941530631,58.4547574725378,46.7514830195167,72,8,0,0,8,0,0,0,0,4,0,0,4,0,0,0,0,0,0,0,0,8,0,6,4,-0.144376899696049,-0.222222222222222,0.128848549304701,-0.158908780903666,-0.159685863874345,0.894736842105263,-0.983525535420099,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","150/150","K:Q",4.06858121107736,9.193364498612e-05,1.04030498364652,3.91095041842056,11.5166635599539,1065.61332397744,1.76696293519342,6.68324361543955e-09,8.17501270782547,8.64086529870195,2465.74647273772,8.05839318437163e-12,"lineage4","dr_mutations_pyrazinamide","THR",0,"ERR464719","ERR464719","lineage4.4.1.1","ch","Switzerland","pnca_p.lys96thr","A","E","LYS","KA96","pnca_complex.pdb"
|
|
"K96T","L4","PZA","K","K96",96,"T",NA,"MDR","DM","hydrophobic","hydrophobic","basic","neutral","pos","polar",3.977,-0.57,-0.86,3.53764,-0.932,-0.61,85,91,-1.194,9,9,8,0.0338983050847457,"strand",-1.86666666666667,5.96,0.0009343107661348,58.4740177439797,58.473941530631,58.4547574725378,46.7514830195167,72,8,0,0,8,0,0,0,0,4,0,0,4,0,0,0,0,0,0,0,0,8,0,6,4,-0.144376899696049,-0.222222222222222,0.128848549304701,-0.158908780903666,-0.159685863874345,0.894736842105263,-0.983525535420099,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","150/150","K:Q",4.06858121107736,9.193364498612e-05,1.04030498364652,3.91095041842056,11.5166635599539,1065.61332397744,1.76696293519342,6.68324361543955e-09,8.17501270782547,8.64086529870195,2465.74647273772,8.05839318437163e-12,"lineage4","dr_mutations_pyrazinamide","THR",0,"ERR2706976","ERR2706976","lineage4.3.2","cd","Democratic Republic of Congo","pnca_p.lys96thr","A","E","LYS","KA96","pnca_complex.pdb"
|
|
"K96T","L4","PZA","K","K96",96,"T",1,"XDR","DM","hydrophobic","hydrophobic","basic","neutral","pos","polar",3.977,-0.57,-0.86,3.53764,-0.932,-0.61,85,91,-1.194,9,9,8,0.0338983050847457,"strand",-1.86666666666667,5.96,0.0009343107661348,58.4740177439797,58.473941530631,58.4547574725378,46.7514830195167,72,8,0,0,8,0,0,0,0,4,0,0,4,0,0,0,0,0,0,0,0,8,0,6,4,-0.144376899696049,-0.222222222222222,0.128848549304701,-0.158908780903666,-0.159685863874345,0.894736842105263,-0.983525535420099,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","150/150","K:Q",4.06858121107736,9.193364498612e-05,1.04030498364652,3.91095041842056,11.5166635599539,1065.61332397744,1.76696293519342,6.68324361543955e-09,8.17501270782547,8.64086529870195,2465.74647273772,8.05839318437163e-12,"lineage4","dr_mutations_pyrazinamide","THR",0,"ERR2516995","ERR2516995","lineage4.2.1","gb","UK","pnca_p.lys96thr","A","E","LYS","KA96","pnca_complex.pdb"
|
|
"K96T","L2","PZA","K","K96",96,"T",1,"Pre-XDR","DM","hydrophobic","hydrophobic","basic","neutral","pos","polar",3.977,-0.57,-0.86,3.53764,-0.932,-0.61,85,91,-1.194,9,9,8,0.0338983050847457,"strand",-1.86666666666667,5.96,0.0009343107661348,58.4740177439797,58.473941530631,58.4547574725378,46.7514830195167,72,8,0,0,8,0,0,0,0,4,0,0,4,0,0,0,0,0,0,0,0,8,0,6,4,-0.144376899696049,-0.222222222222222,0.128848549304701,-0.158908780903666,-0.159685863874345,0.894736842105263,-0.983525535420099,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","150/150","K:Q",4.06858121107736,9.193364498612e-05,1.04030498364652,3.91095041842056,11.5166635599539,1065.61332397744,1.76696293519342,6.68324361543955e-09,8.17501270782547,8.64086529870195,2465.74647273772,8.05839318437163e-12,"lineage2","dr_mutations_pyrazinamide","THR",0,"SAMN10961335","SRR8651570","lineage2.2.1","cn","China:Wenzhou","pnca_p.lys96thr","A","E","LYS","KA96","pnca_complex.pdb"
|
|
"K96T","L2","PZA","K","K96",96,"T",NA,"XDR","DM","hydrophobic","hydrophobic","basic","neutral","pos","polar",3.977,-0.57,-0.86,3.53764,-0.932,-0.61,85,91,-1.194,9,9,8,0.0338983050847457,"strand",-1.86666666666667,5.96,0.0009343107661348,58.4740177439797,58.473941530631,58.4547574725378,46.7514830195167,72,8,0,0,8,0,0,0,0,4,0,0,4,0,0,0,0,0,0,0,0,8,0,6,4,-0.144376899696049,-0.222222222222222,0.128848549304701,-0.158908780903666,-0.159685863874345,0.894736842105263,-0.983525535420099,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","150/150","K:Q",4.06858121107736,9.193364498612e-05,1.04030498364652,3.91095041842056,11.5166635599539,1065.61332397744,1.76696293519342,6.68324361543955e-09,8.17501270782547,8.64086529870195,2465.74647273772,8.05839318437163e-12,"lineage2","dr_mutations_pyrazinamide","THR",0,"SAMN07236518,SRR5709891","SRR5709891","lineage2.2.1","th","Thailand","pnca_p.lys96thr","A","E","LYS","KA96","pnca_complex.pdb"
|
|
"K96T","L2","PZA","K","K96",96,"T",1,"MDR","DM","hydrophobic","hydrophobic","basic","neutral","pos","polar",3.977,-0.57,-0.86,3.53764,-0.932,-0.61,85,91,-1.194,9,9,8,0.0338983050847457,"strand",-1.86666666666667,5.96,0.0009343107661348,58.4740177439797,58.473941530631,58.4547574725378,46.7514830195167,72,8,0,0,8,0,0,0,0,4,0,0,4,0,0,0,0,0,0,0,0,8,0,6,4,-0.144376899696049,-0.222222222222222,0.128848549304701,-0.158908780903666,-0.159685863874345,0.894736842105263,-0.983525535420099,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","150/150","K:Q",4.06858121107736,9.193364498612e-05,1.04030498364652,3.91095041842056,11.5166635599539,1065.61332397744,1.76696293519342,6.68324361543955e-09,8.17501270782547,8.64086529870195,2465.74647273772,8.05839318437163e-12,"lineage2","dr_mutations_pyrazinamide","THR",0,"ERR551494","ERR551494","lineage2.2.1","tm","Turkmenistan","pnca_p.lys96thr","A","E","LYS","KA96","pnca_complex.pdb"
|
|
"K96T","L4","PZA","K","K96",96,"T",NA,"MDR","DM","hydrophobic","hydrophobic","basic","neutral","pos","polar",3.977,-0.57,-0.86,3.53764,-0.932,-0.61,85,91,-1.194,9,9,8,0.0338983050847457,"strand",-1.86666666666667,5.96,0.0009343107661348,58.4740177439797,58.473941530631,58.4547574725378,46.7514830195167,72,8,0,0,8,0,0,0,0,4,0,0,4,0,0,0,0,0,0,0,0,8,0,6,4,-0.144376899696049,-0.222222222222222,0.128848549304701,-0.158908780903666,-0.159685863874345,0.894736842105263,-0.983525535420099,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","150/150","K:Q",4.06858121107736,9.193364498612e-05,1.04030498364652,3.91095041842056,11.5166635599539,1065.61332397744,1.76696293519342,6.68324361543955e-09,8.17501270782547,8.64086529870195,2465.74647273772,8.05839318437163e-12,"lineage4","dr_mutations_pyrazinamide","THR",0,"SRR7517716","SRR7517716","lineage4.4.1.1","ch","Switzerland","pnca_p.lys96thr","A","E","LYS","KA96","pnca_complex.pdb"
|
|
"K96T","L4","PZA","K","K96",96,"T",0,"Pre-XDR","DM","hydrophobic","hydrophobic","basic","neutral","pos","polar",3.977,-0.57,-0.86,3.53764,-0.932,-0.61,85,91,-1.194,9,9,8,0.0338983050847457,"strand",-1.86666666666667,5.96,0.0009343107661348,58.4740177439797,58.473941530631,58.4547574725378,46.7514830195167,72,8,0,0,8,0,0,0,0,4,0,0,4,0,0,0,0,0,0,0,0,8,0,6,4,-0.144376899696049,-0.222222222222222,0.128848549304701,-0.158908780903666,-0.159685863874345,0.894736842105263,-0.983525535420099,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","150/150","K:Q",4.06858121107736,9.193364498612e-05,1.04030498364652,3.91095041842056,11.5166635599539,1065.61332397744,1.76696293519342,6.68324361543955e-09,8.17501270782547,8.64086529870195,2465.74647273772,8.05839318437163e-12,"lineage4","dr_mutations_pyrazinamide","THR",0,"ERR3335736","ERR3335736","lineage4.5","pk","Pakistan","pnca_p.lys96thr","A","E","LYS","KA96","pnca_complex.pdb"
|
|
"K96T","L2","PZA","K","K96",96,"T",1,"XDR","DM","hydrophobic","hydrophobic","basic","neutral","pos","polar",3.977,-0.57,-0.86,3.53764,-0.932,-0.61,85,91,-1.194,9,9,8,0.0338983050847457,"strand",-1.86666666666667,5.96,0.0009343107661348,58.4740177439797,58.473941530631,58.4547574725378,46.7514830195167,72,8,0,0,8,0,0,0,0,4,0,0,4,0,0,0,0,0,0,0,0,8,0,6,4,-0.144376899696049,-0.222222222222222,0.128848549304701,-0.158908780903666,-0.159685863874345,0.894736842105263,-0.983525535420099,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","150/150","K:Q",4.06858121107736,9.193364498612e-05,1.04030498364652,3.91095041842056,11.5166635599539,1065.61332397744,1.76696293519342,6.68324361543955e-09,8.17501270782547,8.64086529870195,2465.74647273772,8.05839318437163e-12,"lineage2","dr_mutations_pyrazinamide","THR",0,"ERR552429","ERR552429","lineage2.2.1","ru","Russia","pnca_p.lys96thr","A","E","LYS","KA96","pnca_complex.pdb"
|
|
"K96T","L2","PZA","K","K96",96,"T",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","basic","neutral","pos","polar",3.977,-0.57,-0.86,3.53764,-0.932,-0.61,85,91,-1.194,9,9,8,0.0338983050847457,"strand",-1.86666666666667,5.96,0.0009343107661348,58.4740177439797,58.473941530631,58.4547574725378,46.7514830195167,72,8,0,0,8,0,0,0,0,4,0,0,4,0,0,0,0,0,0,0,0,8,0,6,4,-0.144376899696049,-0.222222222222222,0.128848549304701,-0.158908780903666,-0.159685863874345,0.894736842105263,-0.983525535420099,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","150/150","K:Q",4.06858121107736,9.193364498612e-05,1.04030498364652,3.91095041842056,11.5166635599539,1065.61332397744,1.76696293519342,6.68324361543955e-09,8.17501270782547,8.64086529870195,2465.74647273772,8.05839318437163e-12,"lineage2","dr_mutations_pyrazinamide","THR",0,"SRR5709869","SRR5709869","lineage2.2.1","th","Thailand","pnca_p.lys96thr","A","E","LYS","KA96","pnca_complex.pdb"
|
|
"K96T","L4","PZA","K","K96",96,"T",1,"MDR","DM","hydrophobic","hydrophobic","basic","neutral","pos","polar",3.977,-0.57,-0.86,3.53764,-0.932,-0.61,85,91,-1.194,9,9,8,0.0338983050847457,"strand",-1.86666666666667,5.96,0.0009343107661348,58.4740177439797,58.473941530631,58.4547574725378,46.7514830195167,72,8,0,0,8,0,0,0,0,4,0,0,4,0,0,0,0,0,0,0,0,8,0,6,4,-0.144376899696049,-0.222222222222222,0.128848549304701,-0.158908780903666,-0.159685863874345,0.894736842105263,-0.983525535420099,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","150/150","K:Q",4.06858121107736,9.193364498612e-05,1.04030498364652,3.91095041842056,11.5166635599539,1065.61332397744,1.76696293519342,6.68324361543955e-09,8.17501270782547,8.64086529870195,2465.74647273772,8.05839318437163e-12,"lineage4","dr_mutations_pyrazinamide","THR",0,"ERR2516641","ERR2516641","lineage4.4.1.1","nl","Netherlands","pnca_p.lys96thr","A","E","LYS","KA96","pnca_complex.pdb"
|
|
"K96T","L4","PZA","K","K96",96,"T",1,"MDR","DM","hydrophobic","hydrophobic","basic","neutral","pos","polar",3.977,-0.57,-0.86,3.53764,-0.932,-0.61,85,91,-1.194,9,9,8,0.0338983050847457,"strand",-1.86666666666667,5.96,0.0009343107661348,58.4740177439797,58.473941530631,58.4547574725378,46.7514830195167,72,8,0,0,8,0,0,0,0,4,0,0,4,0,0,0,0,0,0,0,0,8,0,6,4,-0.144376899696049,-0.222222222222222,0.128848549304701,-0.158908780903666,-0.159685863874345,0.894736842105263,-0.983525535420099,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","150/150","K:Q",4.06858121107736,9.193364498612e-05,1.04030498364652,3.91095041842056,11.5166635599539,1065.61332397744,1.76696293519342,6.68324361543955e-09,8.17501270782547,8.64086529870195,2465.74647273772,8.05839318437163e-12,"lineage4","dr_mutations_pyrazinamide","THR",0,"ERR2515759","ERR2515759","lineage4.3.2.1","za","South Africa","pnca_p.lys96thr","A","E","LYS","KA96","pnca_complex.pdb"
|
|
"K96T","L4","PZA","K","K96",96,"T",NA,"MDR","DM","hydrophobic","hydrophobic","basic","neutral","pos","polar",3.977,-0.57,-0.86,3.53764,-0.932,-0.61,85,91,-1.194,9,9,8,0.0338983050847457,"strand",-1.86666666666667,5.96,0.0009343107661348,58.4740177439797,58.473941530631,58.4547574725378,46.7514830195167,72,8,0,0,8,0,0,0,0,4,0,0,4,0,0,0,0,0,0,0,0,8,0,6,4,-0.144376899696049,-0.222222222222222,0.128848549304701,-0.158908780903666,-0.159685863874345,0.894736842105263,-0.983525535420099,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","150/150","K:Q",4.06858121107736,9.193364498612e-05,1.04030498364652,3.91095041842056,11.5166635599539,1065.61332397744,1.76696293519342,6.68324361543955e-09,8.17501270782547,8.64086529870195,2465.74647273772,8.05839318437163e-12,"lineage4","dr_mutations_pyrazinamide","THR",0,"ERR2707028","ERR2707028","lineage4.3.2","cd","Democratic Republic of Congo","pnca_p.lys96thr","A","E","LYS","KA96","pnca_complex.pdb"
|
|
"K96T","L2","PZA","K","K96",96,"T",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","basic","neutral","pos","polar",3.977,-0.57,-0.86,3.53764,-0.932,-0.61,85,91,-1.194,9,9,8,0.0338983050847457,"strand",-1.86666666666667,5.96,0.0009343107661348,58.4740177439797,58.473941530631,58.4547574725378,46.7514830195167,72,8,0,0,8,0,0,0,0,4,0,0,4,0,0,0,0,0,0,0,0,8,0,6,4,-0.144376899696049,-0.222222222222222,0.128848549304701,-0.158908780903666,-0.159685863874345,0.894736842105263,-0.983525535420099,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","150/150","K:Q",4.06858121107736,9.193364498612e-05,1.04030498364652,3.91095041842056,11.5166635599539,1065.61332397744,1.76696293519342,6.68324361543955e-09,8.17501270782547,8.64086529870195,2465.74647273772,8.05839318437163e-12,"lineage2","dr_mutations_pyrazinamide","THR",0,"SRR5266536","SRR5266536","lineage2.2.1","ru","Russia","pnca_p.lys96thr","A","E","LYS","KA96","pnca_complex.pdb"
|
|
"K96T","L4","PZA","K","K96",96,"T",NA,"MDR","DM","hydrophobic","hydrophobic","basic","neutral","pos","polar",3.977,-0.57,-0.86,3.53764,-0.932,-0.61,85,91,-1.194,9,9,8,0.0338983050847457,"strand",-1.86666666666667,5.96,0.0009343107661348,58.4740177439797,58.473941530631,58.4547574725378,46.7514830195167,72,8,0,0,8,0,0,0,0,4,0,0,4,0,0,0,0,0,0,0,0,8,0,6,4,-0.144376899696049,-0.222222222222222,0.128848549304701,-0.158908780903666,-0.159685863874345,0.894736842105263,-0.983525535420099,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","150/150","K:Q",4.06858121107736,9.193364498612e-05,1.04030498364652,3.91095041842056,11.5166635599539,1065.61332397744,1.76696293519342,6.68324361543955e-09,8.17501270782547,8.64086529870195,2465.74647273772,8.05839318437163e-12,"lineage4","dr_mutations_pyrazinamide","THR",0,"SAMN02231187","SRR998837_SRR998840_SRR998838_SRR998839","lineage4.1","ml","Mali","pnca_p.lys96thr","A","E","LYS","KA96","pnca_complex.pdb"
|
|
"K96T","L4","PZA","K","K96",96,"T",1,"Pre-XDR","DM","hydrophobic","hydrophobic","basic","neutral","pos","polar",3.977,-0.57,-0.86,3.53764,-0.932,-0.61,85,91,-1.194,9,9,8,0.0338983050847457,"strand",-1.86666666666667,5.96,0.0009343107661348,58.4740177439797,58.473941530631,58.4547574725378,46.7514830195167,72,8,0,0,8,0,0,0,0,4,0,0,4,0,0,0,0,0,0,0,0,8,0,6,4,-0.144376899696049,-0.222222222222222,0.128848549304701,-0.158908780903666,-0.159685863874345,0.894736842105263,-0.983525535420099,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","150/150","K:Q",4.06858121107736,9.193364498612e-05,1.04030498364652,3.91095041842056,11.5166635599539,1065.61332397744,1.76696293519342,6.68324361543955e-09,8.17501270782547,8.64086529870195,2465.74647273772,8.05839318437163e-12,"lineage4","dr_mutations_pyrazinamide","THR",0,"SAMN03647565,SRR2100392","SRR2100392","lineage4.4.1.1","","","pnca_p.lys96thr","A","E","LYS","KA96","pnca_complex.pdb"
|
|
"K96T","L4","PZA","K","K96",96,"T",1,"Pre-XDR","DM","hydrophobic","hydrophobic","basic","neutral","pos","polar",3.977,-0.57,-0.86,3.53764,-0.932,-0.61,85,91,-1.194,9,9,8,0.0338983050847457,"strand",-1.86666666666667,5.96,0.0009343107661348,58.4740177439797,58.473941530631,58.4547574725378,46.7514830195167,72,8,0,0,8,0,0,0,0,4,0,0,4,0,0,0,0,0,0,0,0,8,0,6,4,-0.144376899696049,-0.222222222222222,0.128848549304701,-0.158908780903666,-0.159685863874345,0.894736842105263,-0.983525535420099,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","150/150","K:Q",4.06858121107736,9.193364498612e-05,1.04030498364652,3.91095041842056,11.5166635599539,1065.61332397744,1.76696293519342,6.68324361543955e-09,8.17501270782547,8.64086529870195,2465.74647273772,8.05839318437163e-12,"lineage4","dr_mutations_pyrazinamide","THR",0,"ERR2513352","ERR2513352","lineage4.4.1.1","gb","UK","pnca_p.lys96thr","A","E","LYS","KA96","pnca_complex.pdb"
|
|
"K96T","L2","PZA","K","K96",96,"T",1,"Pre-XDR","DM","hydrophobic","hydrophobic","basic","neutral","pos","polar",3.977,-0.57,-0.86,3.53764,-0.932,-0.61,85,91,-1.194,9,9,8,0.0338983050847457,"strand",-1.86666666666667,5.96,0.0009343107661348,58.4740177439797,58.473941530631,58.4547574725378,46.7514830195167,72,8,0,0,8,0,0,0,0,4,0,0,4,0,0,0,0,0,0,0,0,8,0,6,4,-0.144376899696049,-0.222222222222222,0.128848549304701,-0.158908780903666,-0.159685863874345,0.894736842105263,-0.983525535420099,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","150/150","K:Q",4.06858121107736,9.193364498612e-05,1.04030498364652,3.91095041842056,11.5166635599539,1065.61332397744,1.76696293519342,6.68324361543955e-09,8.17501270782547,8.64086529870195,2465.74647273772,8.05839318437163e-12,"lineage2","dr_mutations_pyrazinamide","THR",0,"SAMN10961323","SRR8651655","lineage2.2.1","cn","China:Wenzhou","pnca_p.lys96thr","A","E","LYS","KA96","pnca_complex.pdb"
|
|
"G97A","L4","PZA","G","G97",97,"A",NA,"MDR","OM","hydrophobic","hydrophobic","neutral","non-polar","non-polar","non-polar",8.236,-1.721,-1.126,3.72826,-1.921,-0.73,66,80,-1.026,9,9,7,0.0673076923076923,"loop",-0.833333333333333,4.92,NA,NA,NA,NA,NA,-6,0,0,0,0,0,0,0,0,0,0,2,-2,0,0,0,0,-4,0,0,-4,-2,0,-1,-16,-0.435916919959473,-0.290956072351421,0.135791344633921,-0.327536231884058,-0.19109947643979,0.694736842105263,-0.845140032948929,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.124,-0.993,"9:9","150/150","A:G",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage4","other_mutations_pyrazinamide","ALA",0,"SAMN02231160","SRR998769_SRR998771_SRR998770_SRR998768","lineage4.1","ml","Mali","pnca_p.gly97ala","A","-","GLY","GA97","pnca_complex.pdb"
|
|
"G97A","L4","PZA","G","G97",97,"A",NA,"Pre-XDR","OM","hydrophobic","hydrophobic","neutral","non-polar","non-polar","non-polar",8.236,-1.721,-1.126,3.72826,-1.921,-0.73,66,80,-1.026,9,9,7,0.0673076923076923,"loop",-0.833333333333333,4.92,NA,NA,NA,NA,NA,-6,0,0,0,0,0,0,0,0,0,0,2,-2,0,0,0,0,-4,0,0,-4,-2,0,-1,-16,-0.435916919959473,-0.290956072351421,0.135791344633921,-0.327536231884058,-0.19109947643979,0.694736842105263,-0.845140032948929,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.124,-0.993,"9:9","150/150","A:G",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage4","other_mutations_pyrazinamide","ALA",0,"ERR3148167","ERR3148167","lineage4.3.2","mx","Mexico","pnca_p.gly97ala","A","-","GLY","GA97","pnca_complex.pdb"
|
|
"G97C","L4","PZA","G","G97",97,"C",1,"Pre-XDR","DM","hydrophobic","hydrophobic","neutral","neutral","non-polar","non-polar",8.236,-1.158,-1.635,4.47159,-1.484,-0.7,69,80,-1.026,9,9,7,0.0673076923076923,"loop",-0.833333333333333,4.92,0.0007187005893344,97.3828619670747,1395803.74890115,Inf,42.8452490786805,-10,-2,0,0,-2,0,0,0,0,0,0,2,-2,0,0,0,0,-9,0,-3,-11,-8,0,-7,-21,-0.293313069908815,-0.422480620155039,0.162865041266326,-0.253026427962489,-0.183246073298429,0.726315789473684,-0.845140032948929,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.124,-0.993,"9:9","150/150","A:G",14.1489809714057,0.890414731995348,102.692976013979,0.137779442378606,507.712885369765,NA,1.98848253379833,2.1018584548314e-08,7.67739653395739,10.9022485555592,Inf,5.92457926729285e-11,"lineage4","dr_mutations_pyrazinamide","CYS",0,"ERR551166","ERR551166","lineage4.1.1.1","sz","Swaziland","pnca_p.gly97cys","A","-","GLY","GA97","pnca_complex.pdb"
|
|
"G97C","L4","PZA","G","G97",97,"C",NA,"MDR","DM","hydrophobic","hydrophobic","neutral","neutral","non-polar","non-polar",8.236,-1.158,-1.635,4.47159,-1.484,-0.7,69,80,-1.026,9,9,7,0.0673076923076923,"loop",-0.833333333333333,4.92,0.0007187005893344,97.3828619670747,1395803.74890115,Inf,42.8452490786805,-10,-2,0,0,-2,0,0,0,0,0,0,2,-2,0,0,0,0,-9,0,-3,-11,-8,0,-7,-21,-0.293313069908815,-0.422480620155039,0.162865041266326,-0.253026427962489,-0.183246073298429,0.726315789473684,-0.845140032948929,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.124,-0.993,"9:9","150/150","A:G",14.1489809714057,0.890414731995348,102.692976013979,0.137779442378606,507.712885369765,NA,1.98848253379833,2.1018584548314e-08,7.67739653395739,10.9022485555592,Inf,5.92457926729285e-11,"lineage4","dr_mutations_pyrazinamide","CYS",0,"SRR7341689","SRR7341689","lineage4.4.1.1","ro","Romania","pnca_p.gly97cys","A","-","GLY","GA97","pnca_complex.pdb"
|
|
"G97C","L4","PZA","G","G97",97,"C",1,"MDR","DM","hydrophobic","hydrophobic","neutral","neutral","non-polar","non-polar",8.236,-1.158,-1.635,4.47159,-1.484,-0.7,69,80,-1.026,9,9,7,0.0673076923076923,"loop",-0.833333333333333,4.92,0.0007187005893344,97.3828619670747,1395803.74890115,Inf,42.8452490786805,-10,-2,0,0,-2,0,0,0,0,0,0,2,-2,0,0,0,0,-9,0,-3,-11,-8,0,-7,-21,-0.293313069908815,-0.422480620155039,0.162865041266326,-0.253026427962489,-0.183246073298429,0.726315789473684,-0.845140032948929,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.124,-0.993,"9:9","150/150","A:G",14.1489809714057,0.890414731995348,102.692976013979,0.137779442378606,507.712885369765,NA,1.98848253379833,2.1018584548314e-08,7.67739653395739,10.9022485555592,Inf,5.92457926729285e-11,"lineage4","dr_mutations_pyrazinamide","CYS",0,"ERR551456","ERR551456","lineage4.1.1.1","sz","Swaziland","pnca_p.gly97cys","A","-","GLY","GA97","pnca_complex.pdb"
|
|
"G97C","L4","PZA","G","G97",97,"C",1,"MDR","DM","hydrophobic","hydrophobic","neutral","neutral","non-polar","non-polar",8.236,-1.158,-1.635,4.47159,-1.484,-0.7,69,80,-1.026,9,9,7,0.0673076923076923,"loop",-0.833333333333333,4.92,0.0007187005893344,97.3828619670747,1395803.74890115,Inf,42.8452490786805,-10,-2,0,0,-2,0,0,0,0,0,0,2,-2,0,0,0,0,-9,0,-3,-11,-8,0,-7,-21,-0.293313069908815,-0.422480620155039,0.162865041266326,-0.253026427962489,-0.183246073298429,0.726315789473684,-0.845140032948929,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.124,-0.993,"9:9","150/150","A:G",14.1489809714057,0.890414731995348,102.692976013979,0.137779442378606,507.712885369765,NA,1.98848253379833,2.1018584548314e-08,7.67739653395739,10.9022485555592,Inf,5.92457926729285e-11,"lineage4","dr_mutations_pyrazinamide","CYS",0,"SRR2101307,SAMN03648554","SRR2101307","lineage4.1.1.1","","","pnca_p.gly97cys","A","-","GLY","GA97","pnca_complex.pdb"
|
|
"G97C","L4","PZA","G","G97",97,"C",1,"Pre-XDR","DM","hydrophobic","hydrophobic","neutral","neutral","non-polar","non-polar",8.236,-1.158,-1.635,4.47159,-1.484,-0.7,69,80,-1.026,9,9,7,0.0673076923076923,"loop",-0.833333333333333,4.92,0.0007187005893344,97.3828619670747,1395803.74890115,Inf,42.8452490786805,-10,-2,0,0,-2,0,0,0,0,0,0,2,-2,0,0,0,0,-9,0,-3,-11,-8,0,-7,-21,-0.293313069908815,-0.422480620155039,0.162865041266326,-0.253026427962489,-0.183246073298429,0.726315789473684,-0.845140032948929,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.124,-0.993,"9:9","150/150","A:G",14.1489809714057,0.890414731995348,102.692976013979,0.137779442378606,507.712885369765,NA,1.98848253379833,2.1018584548314e-08,7.67739653395739,10.9022485555592,Inf,5.92457926729285e-11,"lineage4","dr_mutations_pyrazinamide","CYS",0,"ERR552710","ERR552710","lineage4.1.1.1","sz","Swaziland","pnca_p.gly97cys","A","-","GLY","GA97","pnca_complex.pdb"
|
|
"G97C","L4","PZA","G","G97",97,"C",1,"MDR","DM","hydrophobic","hydrophobic","neutral","neutral","non-polar","non-polar",8.236,-1.158,-1.635,4.47159,-1.484,-0.7,69,80,-1.026,9,9,7,0.0673076923076923,"loop",-0.833333333333333,4.92,0.0007187005893344,97.3828619670747,1395803.74890115,Inf,42.8452490786805,-10,-2,0,0,-2,0,0,0,0,0,0,2,-2,0,0,0,0,-9,0,-3,-11,-8,0,-7,-21,-0.293313069908815,-0.422480620155039,0.162865041266326,-0.253026427962489,-0.183246073298429,0.726315789473684,-0.845140032948929,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.124,-0.993,"9:9","150/150","A:G",14.1489809714057,0.890414731995348,102.692976013979,0.137779442378606,507.712885369765,NA,1.98848253379833,2.1018584548314e-08,7.67739653395739,10.9022485555592,Inf,5.92457926729285e-11,"lineage4","dr_mutations_pyrazinamide","CYS",0,"ERR551896","ERR551896","lineage4.1.1.1","sz","Swaziland","pnca_p.gly97cys","A","-","GLY","GA97","pnca_complex.pdb"
|
|
"G97C","L4","PZA","G","G97",97,"C",NA,"MDR","DM","hydrophobic","hydrophobic","neutral","neutral","non-polar","non-polar",8.236,-1.158,-1.635,4.47159,-1.484,-0.7,69,80,-1.026,9,9,7,0.0673076923076923,"loop",-0.833333333333333,4.92,0.0007187005893344,97.3828619670747,1395803.74890115,Inf,42.8452490786805,-10,-2,0,0,-2,0,0,0,0,0,0,2,-2,0,0,0,0,-9,0,-3,-11,-8,0,-7,-21,-0.293313069908815,-0.422480620155039,0.162865041266326,-0.253026427962489,-0.183246073298429,0.726315789473684,-0.845140032948929,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.124,-0.993,"9:9","150/150","A:G",14.1489809714057,0.890414731995348,102.692976013979,0.137779442378606,507.712885369765,NA,1.98848253379833,2.1018584548314e-08,7.67739653395739,10.9022485555592,Inf,5.92457926729285e-11,"lineage4","dr_mutations_pyrazinamide","CYS",0,"SRR7341703","SRR7341703","lineage4.4.1.1","ro","Romania","pnca_p.gly97cys","A","-","GLY","GA97","pnca_complex.pdb"
|
|
"G97C","L4","PZA","G","G97",97,"C",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","neutral","neutral","non-polar","non-polar",8.236,-1.158,-1.635,4.47159,-1.484,-0.7,69,80,-1.026,9,9,7,0.0673076923076923,"loop",-0.833333333333333,4.92,0.0007187005893344,97.3828619670747,1395803.74890115,Inf,42.8452490786805,-10,-2,0,0,-2,0,0,0,0,0,0,2,-2,0,0,0,0,-9,0,-3,-11,-8,0,-7,-21,-0.293313069908815,-0.422480620155039,0.162865041266326,-0.253026427962489,-0.183246073298429,0.726315789473684,-0.845140032948929,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.124,-0.993,"9:9","150/150","A:G",14.1489809714057,0.890414731995348,102.692976013979,0.137779442378606,507.712885369765,NA,1.98848253379833,2.1018584548314e-08,7.67739653395739,10.9022485555592,Inf,5.92457926729285e-11,"lineage4","dr_mutations_pyrazinamide","CYS",0,"SRR7341684","SRR7341684","lineage4.4.1.1","ro","Romania","pnca_p.gly97cys","A","-","GLY","GA97","pnca_complex.pdb"
|
|
"G97C","L4","PZA","G","G97",97,"C",NA,"MDR","DM","hydrophobic","hydrophobic","neutral","neutral","non-polar","non-polar",8.236,-1.158,-1.635,4.47159,-1.484,-0.7,69,80,-1.026,9,9,7,0.0673076923076923,"loop",-0.833333333333333,4.92,0.0007187005893344,97.3828619670747,1395803.74890115,Inf,42.8452490786805,-10,-2,0,0,-2,0,0,0,0,0,0,2,-2,0,0,0,0,-9,0,-3,-11,-8,0,-7,-21,-0.293313069908815,-0.422480620155039,0.162865041266326,-0.253026427962489,-0.183246073298429,0.726315789473684,-0.845140032948929,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.124,-0.993,"9:9","150/150","A:G",14.1489809714057,0.890414731995348,102.692976013979,0.137779442378606,507.712885369765,NA,1.98848253379833,2.1018584548314e-08,7.67739653395739,10.9022485555592,Inf,5.92457926729285e-11,"lineage4","dr_mutations_pyrazinamide","CYS",0,"ERR1034904","ERR1034904","lineage4.4.1.1","pt","Portugal","pnca_p.gly97cys","A","-","GLY","GA97","pnca_complex.pdb"
|
|
"G97C","L4","PZA","G","G97",97,"C",1,"Pre-MDR","DM","hydrophobic","hydrophobic","neutral","neutral","non-polar","non-polar",8.236,-1.158,-1.635,4.47159,-1.484,-0.7,69,80,-1.026,9,9,7,0.0673076923076923,"loop",-0.833333333333333,4.92,0.0007187005893344,97.3828619670747,1395803.74890115,Inf,42.8452490786805,-10,-2,0,0,-2,0,0,0,0,0,0,2,-2,0,0,0,0,-9,0,-3,-11,-8,0,-7,-21,-0.293313069908815,-0.422480620155039,0.162865041266326,-0.253026427962489,-0.183246073298429,0.726315789473684,-0.845140032948929,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.124,-0.993,"9:9","150/150","A:G",14.1489809714057,0.890414731995348,102.692976013979,0.137779442378606,507.712885369765,NA,1.98848253379833,2.1018584548314e-08,7.67739653395739,10.9022485555592,Inf,5.92457926729285e-11,"lineage4","dr_mutations_pyrazinamide","CYS",0,"ERR553182","ERR553182","lineage4.1.1.1","sz","Swaziland","pnca_p.gly97cys","A","-","GLY","GA97","pnca_complex.pdb"
|
|
"G97C","L4","PZA","G","G97",97,"C",NA,"MDR","DM","hydrophobic","hydrophobic","neutral","neutral","non-polar","non-polar",8.236,-1.158,-1.635,4.47159,-1.484,-0.7,69,80,-1.026,9,9,7,0.0673076923076923,"loop",-0.833333333333333,4.92,0.0007187005893344,97.3828619670747,1395803.74890115,Inf,42.8452490786805,-10,-2,0,0,-2,0,0,0,0,0,0,2,-2,0,0,0,0,-9,0,-3,-11,-8,0,-7,-21,-0.293313069908815,-0.422480620155039,0.162865041266326,-0.253026427962489,-0.183246073298429,0.726315789473684,-0.845140032948929,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.124,-0.993,"9:9","150/150","A:G",14.1489809714057,0.890414731995348,102.692976013979,0.137779442378606,507.712885369765,NA,1.98848253379833,2.1018584548314e-08,7.67739653395739,10.9022485555592,Inf,5.92457926729285e-11,"lineage4","dr_mutations_pyrazinamide","CYS",0,"SAMN02403574","SRR1169195_SRR1172109_SRR1165671_SRR1165681","lineage4.1.1.1","za","South Africa","pnca_p.gly97cys","A","-","GLY","GA97","pnca_complex.pdb"
|
|
"G97C","L4","PZA","G","G97",97,"C",NA,"MDR","DM","hydrophobic","hydrophobic","neutral","neutral","non-polar","non-polar",8.236,-1.158,-1.635,4.47159,-1.484,-0.7,69,80,-1.026,9,9,7,0.0673076923076923,"loop",-0.833333333333333,4.92,0.0007187005893344,97.3828619670747,1395803.74890115,Inf,42.8452490786805,-10,-2,0,0,-2,0,0,0,0,0,0,2,-2,0,0,0,0,-9,0,-3,-11,-8,0,-7,-21,-0.293313069908815,-0.422480620155039,0.162865041266326,-0.253026427962489,-0.183246073298429,0.726315789473684,-0.845140032948929,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.124,-0.993,"9:9","150/150","A:G",14.1489809714057,0.890414731995348,102.692976013979,0.137779442378606,507.712885369765,NA,1.98848253379833,2.1018584548314e-08,7.67739653395739,10.9022485555592,Inf,5.92457926729285e-11,"lineage4","dr_mutations_pyrazinamide","CYS",0,"ERR1036288","ERR1036288","lineage4.4.1.1","pt","Portugal","pnca_p.gly97cys","A","-","GLY","GA97","pnca_complex.pdb"
|
|
"G97C","L4","PZA","G","G97",97,"C",NA,"XDR","DM","hydrophobic","hydrophobic","neutral","neutral","non-polar","non-polar",8.236,-1.158,-1.635,4.47159,-1.484,-0.7,69,80,-1.026,9,9,7,0.0673076923076923,"loop",-0.833333333333333,4.92,0.0007187005893344,97.3828619670747,1395803.74890115,Inf,42.8452490786805,-10,-2,0,0,-2,0,0,0,0,0,0,2,-2,0,0,0,0,-9,0,-3,-11,-8,0,-7,-21,-0.293313069908815,-0.422480620155039,0.162865041266326,-0.253026427962489,-0.183246073298429,0.726315789473684,-0.845140032948929,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.124,-0.993,"9:9","150/150","A:G",14.1489809714057,0.890414731995348,102.692976013979,0.137779442378606,507.712885369765,NA,1.98848253379833,2.1018584548314e-08,7.67739653395739,10.9022485555592,Inf,5.92457926729285e-11,"lineage4","dr_mutations_pyrazinamide","CYS",0,"SRR7341682","SRR7341682","lineage4.4.1.1","ro","Romania","pnca_p.gly97cys","A","-","GLY","GA97","pnca_complex.pdb"
|
|
"G97C","L4","PZA","G","G97",97,"C",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","neutral","neutral","non-polar","non-polar",8.236,-1.158,-1.635,4.47159,-1.484,-0.7,69,80,-1.026,9,9,7,0.0673076923076923,"loop",-0.833333333333333,4.92,0.0007187005893344,97.3828619670747,1395803.74890115,Inf,42.8452490786805,-10,-2,0,0,-2,0,0,0,0,0,0,2,-2,0,0,0,0,-9,0,-3,-11,-8,0,-7,-21,-0.293313069908815,-0.422480620155039,0.162865041266326,-0.253026427962489,-0.183246073298429,0.726315789473684,-0.845140032948929,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.124,-0.993,"9:9","150/150","A:G",14.1489809714057,0.890414731995348,102.692976013979,0.137779442378606,507.712885369765,NA,1.98848253379833,2.1018584548314e-08,7.67739653395739,10.9022485555592,Inf,5.92457926729285e-11,"lineage4","dr_mutations_pyrazinamide","CYS",0,"SAMN02403602","SRR1169283_SRR1165693_SRR1165707_SRR1169244","lineage4.1.1.1","za","South Africa","pnca_p.gly97cys","A","-","GLY","GA97","pnca_complex.pdb"
|
|
"G97C","L4","PZA","G","G97",97,"C",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","neutral","neutral","non-polar","non-polar",8.236,-1.158,-1.635,4.47159,-1.484,-0.7,69,80,-1.026,9,9,7,0.0673076923076923,"loop",-0.833333333333333,4.92,0.0007187005893344,97.3828619670747,1395803.74890115,Inf,42.8452490786805,-10,-2,0,0,-2,0,0,0,0,0,0,2,-2,0,0,0,0,-9,0,-3,-11,-8,0,-7,-21,-0.293313069908815,-0.422480620155039,0.162865041266326,-0.253026427962489,-0.183246073298429,0.726315789473684,-0.845140032948929,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.124,-0.993,"9:9","150/150","A:G",14.1489809714057,0.890414731995348,102.692976013979,0.137779442378606,507.712885369765,NA,1.98848253379833,2.1018584548314e-08,7.67739653395739,10.9022485555592,Inf,5.92457926729285e-11,"lineage4","dr_mutations_pyrazinamide","CYS",0,"SAMN02403575","SRR1169313_SRR1165724_SRR1169225_SRR1165672","lineage4.1.1.1","za","South Africa","pnca_p.gly97cys","A","-","GLY","GA97","pnca_complex.pdb"
|
|
"G97C","L4","PZA","G","G97",97,"C",NA,"MDR","DM","hydrophobic","hydrophobic","neutral","neutral","non-polar","non-polar",8.236,-1.158,-1.635,4.47159,-1.484,-0.7,69,80,-1.026,9,9,7,0.0673076923076923,"loop",-0.833333333333333,4.92,0.0007187005893344,97.3828619670747,1395803.74890115,Inf,42.8452490786805,-10,-2,0,0,-2,0,0,0,0,0,0,2,-2,0,0,0,0,-9,0,-3,-11,-8,0,-7,-21,-0.293313069908815,-0.422480620155039,0.162865041266326,-0.253026427962489,-0.183246073298429,0.726315789473684,-0.845140032948929,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.124,-0.993,"9:9","150/150","A:G",14.1489809714057,0.890414731995348,102.692976013979,0.137779442378606,507.712885369765,NA,1.98848253379833,2.1018584548314e-08,7.67739653395739,10.9022485555592,Inf,5.92457926729285e-11,"lineage4","dr_mutations_pyrazinamide","CYS",0,"SAMN02403610","SRR1167369_SRR1172177_SRR1165656_SRR1169145","lineage4.1.1.1","za","South Africa","pnca_p.gly97cys","A","-","GLY","GA97","pnca_complex.pdb"
|
|
"G97C","L4","PZA","G","G97",97,"C",NA,"MDR","DM","hydrophobic","hydrophobic","neutral","neutral","non-polar","non-polar",8.236,-1.158,-1.635,4.47159,-1.484,-0.7,69,80,-1.026,9,9,7,0.0673076923076923,"loop",-0.833333333333333,4.92,0.0007187005893344,97.3828619670747,1395803.74890115,Inf,42.8452490786805,-10,-2,0,0,-2,0,0,0,0,0,0,2,-2,0,0,0,0,-9,0,-3,-11,-8,0,-7,-21,-0.293313069908815,-0.422480620155039,0.162865041266326,-0.253026427962489,-0.183246073298429,0.726315789473684,-0.845140032948929,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.124,-0.993,"9:9","150/150","A:G",14.1489809714057,0.890414731995348,102.692976013979,0.137779442378606,507.712885369765,NA,1.98848253379833,2.1018584548314e-08,7.67739653395739,10.9022485555592,Inf,5.92457926729285e-11,"lineage4","dr_mutations_pyrazinamide","CYS",0,"SRR7341686","SRR7341686","lineage4.4.1.1","ro","Romania","pnca_p.gly97cys","A","-","GLY","GA97","pnca_complex.pdb"
|
|
"G97C","L4","PZA","G","G97",97,"C",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","neutral","neutral","non-polar","non-polar",8.236,-1.158,-1.635,4.47159,-1.484,-0.7,69,80,-1.026,9,9,7,0.0673076923076923,"loop",-0.833333333333333,4.92,0.0007187005893344,97.3828619670747,1395803.74890115,Inf,42.8452490786805,-10,-2,0,0,-2,0,0,0,0,0,0,2,-2,0,0,0,0,-9,0,-3,-11,-8,0,-7,-21,-0.293313069908815,-0.422480620155039,0.162865041266326,-0.253026427962489,-0.183246073298429,0.726315789473684,-0.845140032948929,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.124,-0.993,"9:9","150/150","A:G",14.1489809714057,0.890414731995348,102.692976013979,0.137779442378606,507.712885369765,NA,1.98848253379833,2.1018584548314e-08,7.67739653395739,10.9022485555592,Inf,5.92457926729285e-11,"lineage4","dr_mutations_pyrazinamide","CYS",0,"SRR7341654","SRR7341654","lineage4.4.1.1","ro","Romania","pnca_p.gly97cys","A","-","GLY","GA97","pnca_complex.pdb"
|
|
"G97C","L4","PZA","G","G97",97,"C",NA,"MDR","DM","hydrophobic","hydrophobic","neutral","neutral","non-polar","non-polar",8.236,-1.158,-1.635,4.47159,-1.484,-0.7,69,80,-1.026,9,9,7,0.0673076923076923,"loop",-0.833333333333333,4.92,0.0007187005893344,97.3828619670747,1395803.74890115,Inf,42.8452490786805,-10,-2,0,0,-2,0,0,0,0,0,0,2,-2,0,0,0,0,-9,0,-3,-11,-8,0,-7,-21,-0.293313069908815,-0.422480620155039,0.162865041266326,-0.253026427962489,-0.183246073298429,0.726315789473684,-0.845140032948929,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.124,-0.993,"9:9","150/150","A:G",14.1489809714057,0.890414731995348,102.692976013979,0.137779442378606,507.712885369765,NA,1.98848253379833,2.1018584548314e-08,7.67739653395739,10.9022485555592,Inf,5.92457926729285e-11,"lineage4","dr_mutations_pyrazinamide","CYS",0,"SRR7341685","SRR7341685","lineage4.4.1.1","ro","Romania","pnca_p.gly97cys","A","-","GLY","GA97","pnca_complex.pdb"
|
|
"G97C","L4","PZA","G","G97",97,"C",1,"Pre-XDR","DM","hydrophobic","hydrophobic","neutral","neutral","non-polar","non-polar",8.236,-1.158,-1.635,4.47159,-1.484,-0.7,69,80,-1.026,9,9,7,0.0673076923076923,"loop",-0.833333333333333,4.92,0.0007187005893344,97.3828619670747,1395803.74890115,Inf,42.8452490786805,-10,-2,0,0,-2,0,0,0,0,0,0,2,-2,0,0,0,0,-9,0,-3,-11,-8,0,-7,-21,-0.293313069908815,-0.422480620155039,0.162865041266326,-0.253026427962489,-0.183246073298429,0.726315789473684,-0.845140032948929,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.124,-0.993,"9:9","150/150","A:G",14.1489809714057,0.890414731995348,102.692976013979,0.137779442378606,507.712885369765,NA,1.98848253379833,2.1018584548314e-08,7.67739653395739,10.9022485555592,Inf,5.92457926729285e-11,"lineage4","dr_mutations_pyrazinamide","CYS",0,"ERR552273","ERR552273","lineage4.1.1.1","sz","Swaziland","pnca_p.gly97cys","A","-","GLY","GA97","pnca_complex.pdb"
|
|
"G97C","L4","PZA","G","G97",97,"C",NA,"MDR","DM","hydrophobic","hydrophobic","neutral","neutral","non-polar","non-polar",8.236,-1.158,-1.635,4.47159,-1.484,-0.7,69,80,-1.026,9,9,7,0.0673076923076923,"loop",-0.833333333333333,4.92,0.0007187005893344,97.3828619670747,1395803.74890115,Inf,42.8452490786805,-10,-2,0,0,-2,0,0,0,0,0,0,2,-2,0,0,0,0,-9,0,-3,-11,-8,0,-7,-21,-0.293313069908815,-0.422480620155039,0.162865041266326,-0.253026427962489,-0.183246073298429,0.726315789473684,-0.845140032948929,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.124,-0.993,"9:9","150/150","A:G",14.1489809714057,0.890414731995348,102.692976013979,0.137779442378606,507.712885369765,NA,1.98848253379833,2.1018584548314e-08,7.67739653395739,10.9022485555592,Inf,5.92457926729285e-11,"lineage4","dr_mutations_pyrazinamide","CYS",0,"SRR7341655","SRR7341655","lineage4.4.1.1","ro","Romania","pnca_p.gly97cys","A","-","GLY","GA97","pnca_complex.pdb"
|
|
"G97C","L4","PZA","G","G97",97,"C",NA,"MDR","DM","hydrophobic","hydrophobic","neutral","neutral","non-polar","non-polar",8.236,-1.158,-1.635,4.47159,-1.484,-0.7,69,80,-1.026,9,9,7,0.0673076923076923,"loop",-0.833333333333333,4.92,0.0007187005893344,97.3828619670747,1395803.74890115,Inf,42.8452490786805,-10,-2,0,0,-2,0,0,0,0,0,0,2,-2,0,0,0,0,-9,0,-3,-11,-8,0,-7,-21,-0.293313069908815,-0.422480620155039,0.162865041266326,-0.253026427962489,-0.183246073298429,0.726315789473684,-0.845140032948929,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.124,-0.993,"9:9","150/150","A:G",14.1489809714057,0.890414731995348,102.692976013979,0.137779442378606,507.712885369765,NA,1.98848253379833,2.1018584548314e-08,7.67739653395739,10.9022485555592,Inf,5.92457926729285e-11,"lineage4","dr_mutations_pyrazinamide","CYS",0,"SRR7341698","SRR7341698","lineage4.4.1.1","ro","Romania","pnca_p.gly97cys","A","-","GLY","GA97","pnca_complex.pdb"
|
|
"G97C","L4","PZA","G","G97",97,"C",NA,"MDR","DM","hydrophobic","hydrophobic","neutral","neutral","non-polar","non-polar",8.236,-1.158,-1.635,4.47159,-1.484,-0.7,69,80,-1.026,9,9,7,0.0673076923076923,"loop",-0.833333333333333,4.92,0.0007187005893344,97.3828619670747,1395803.74890115,Inf,42.8452490786805,-10,-2,0,0,-2,0,0,0,0,0,0,2,-2,0,0,0,0,-9,0,-3,-11,-8,0,-7,-21,-0.293313069908815,-0.422480620155039,0.162865041266326,-0.253026427962489,-0.183246073298429,0.726315789473684,-0.845140032948929,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.124,-0.993,"9:9","150/150","A:G",14.1489809714057,0.890414731995348,102.692976013979,0.137779442378606,507.712885369765,NA,1.98848253379833,2.1018584548314e-08,7.67739653395739,10.9022485555592,Inf,5.92457926729285e-11,"lineage4","dr_mutations_pyrazinamide","CYS",0,"SAMN02403499","SRR1173638_SRR1165310_SRR1167281_SRR1173312","lineage4.1.1.1","za","South Africa","pnca_p.gly97cys","A","-","GLY","GA97","pnca_complex.pdb"
|
|
"G97C","L4","PZA","G","G97",97,"C",NA,"MDR","DM","hydrophobic","hydrophobic","neutral","neutral","non-polar","non-polar",8.236,-1.158,-1.635,4.47159,-1.484,-0.7,69,80,-1.026,9,9,7,0.0673076923076923,"loop",-0.833333333333333,4.92,0.0007187005893344,97.3828619670747,1395803.74890115,Inf,42.8452490786805,-10,-2,0,0,-2,0,0,0,0,0,0,2,-2,0,0,0,0,-9,0,-3,-11,-8,0,-7,-21,-0.293313069908815,-0.422480620155039,0.162865041266326,-0.253026427962489,-0.183246073298429,0.726315789473684,-0.845140032948929,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.124,-0.993,"9:9","150/150","A:G",14.1489809714057,0.890414731995348,102.692976013979,0.137779442378606,507.712885369765,NA,1.98848253379833,2.1018584548314e-08,7.67739653395739,10.9022485555592,Inf,5.92457926729285e-11,"lineage4","dr_mutations_pyrazinamide","CYS",0,"SRR7341643","SRR7341643","lineage4.4.1.1","ro","Romania","pnca_p.gly97cys","A","-","GLY","GA97","pnca_complex.pdb"
|
|
"G97C","L4","PZA","G","G97",97,"C",1,"MDR","DM","hydrophobic","hydrophobic","neutral","neutral","non-polar","non-polar",8.236,-1.158,-1.635,4.47159,-1.484,-0.7,69,80,-1.026,9,9,7,0.0673076923076923,"loop",-0.833333333333333,4.92,0.0007187005893344,97.3828619670747,1395803.74890115,Inf,42.8452490786805,-10,-2,0,0,-2,0,0,0,0,0,0,2,-2,0,0,0,0,-9,0,-3,-11,-8,0,-7,-21,-0.293313069908815,-0.422480620155039,0.162865041266326,-0.253026427962489,-0.183246073298429,0.726315789473684,-0.845140032948929,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.124,-0.993,"9:9","150/150","A:G",14.1489809714057,0.890414731995348,102.692976013979,0.137779442378606,507.712885369765,NA,1.98848253379833,2.1018584548314e-08,7.67739653395739,10.9022485555592,Inf,5.92457926729285e-11,"lineage4","dr_mutations_pyrazinamide","CYS",0,"ERR2515409","ERR2515409","lineage4.1.1.1","za","South Africa","pnca_p.gly97cys","A","-","GLY","GA97","pnca_complex.pdb"
|
|
"G97C","L4","PZA","G","G97",97,"C",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","neutral","neutral","non-polar","non-polar",8.236,-1.158,-1.635,4.47159,-1.484,-0.7,69,80,-1.026,9,9,7,0.0673076923076923,"loop",-0.833333333333333,4.92,0.0007187005893344,97.3828619670747,1395803.74890115,Inf,42.8452490786805,-10,-2,0,0,-2,0,0,0,0,0,0,2,-2,0,0,0,0,-9,0,-3,-11,-8,0,-7,-21,-0.293313069908815,-0.422480620155039,0.162865041266326,-0.253026427962489,-0.183246073298429,0.726315789473684,-0.845140032948929,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.124,-0.993,"9:9","150/150","A:G",14.1489809714057,0.890414731995348,102.692976013979,0.137779442378606,507.712885369765,NA,1.98848253379833,2.1018584548314e-08,7.67739653395739,10.9022485555592,Inf,5.92457926729285e-11,"lineage4","dr_mutations_pyrazinamide","CYS",0,"SRR7341675","SRR7341675","lineage4.4.1.1","ro","Romania","pnca_p.gly97cys","A","-","GLY","GA97","pnca_complex.pdb"
|
|
"G97C","L4","PZA","G","G97",97,"C",NA,"MDR","DM","hydrophobic","hydrophobic","neutral","neutral","non-polar","non-polar",8.236,-1.158,-1.635,4.47159,-1.484,-0.7,69,80,-1.026,9,9,7,0.0673076923076923,"loop",-0.833333333333333,4.92,0.0007187005893344,97.3828619670747,1395803.74890115,Inf,42.8452490786805,-10,-2,0,0,-2,0,0,0,0,0,0,2,-2,0,0,0,0,-9,0,-3,-11,-8,0,-7,-21,-0.293313069908815,-0.422480620155039,0.162865041266326,-0.253026427962489,-0.183246073298429,0.726315789473684,-0.845140032948929,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.124,-0.993,"9:9","150/150","A:G",14.1489809714057,0.890414731995348,102.692976013979,0.137779442378606,507.712885369765,NA,1.98848253379833,2.1018584548314e-08,7.67739653395739,10.9022485555592,Inf,5.92457926729285e-11,"lineage4","dr_mutations_pyrazinamide","CYS",0,"SAMN02403603","SRR1165722_SRR1167358_SRR1169170_SRR1172081","lineage4.1.1.1","za","South Africa","pnca_p.gly97cys","A","-","GLY","GA97","pnca_complex.pdb"
|
|
"G97C","L4","PZA","G","G97",97,"C",NA,"MDR","DM","hydrophobic","hydrophobic","neutral","neutral","non-polar","non-polar",8.236,-1.158,-1.635,4.47159,-1.484,-0.7,69,80,-1.026,9,9,7,0.0673076923076923,"loop",-0.833333333333333,4.92,0.0007187005893344,97.3828619670747,1395803.74890115,Inf,42.8452490786805,-10,-2,0,0,-2,0,0,0,0,0,0,2,-2,0,0,0,0,-9,0,-3,-11,-8,0,-7,-21,-0.293313069908815,-0.422480620155039,0.162865041266326,-0.253026427962489,-0.183246073298429,0.726315789473684,-0.845140032948929,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.124,-0.993,"9:9","150/150","A:G",14.1489809714057,0.890414731995348,102.692976013979,0.137779442378606,507.712885369765,NA,1.98848253379833,2.1018584548314e-08,7.67739653395739,10.9022485555592,Inf,5.92457926729285e-11,"lineage4","dr_mutations_pyrazinamide","CYS",0,"SRR7341671","SRR7341671","lineage4.4.1.1","ro","Romania","pnca_p.gly97cys","A","-","GLY","GA97","pnca_complex.pdb"
|
|
"G97C","L4","PZA","G","G97",97,"C",1,"Pre-XDR","DM","hydrophobic","hydrophobic","neutral","neutral","non-polar","non-polar",8.236,-1.158,-1.635,4.47159,-1.484,-0.7,69,80,-1.026,9,9,7,0.0673076923076923,"loop",-0.833333333333333,4.92,0.0007187005893344,97.3828619670747,1395803.74890115,Inf,42.8452490786805,-10,-2,0,0,-2,0,0,0,0,0,0,2,-2,0,0,0,0,-9,0,-3,-11,-8,0,-7,-21,-0.293313069908815,-0.422480620155039,0.162865041266326,-0.253026427962489,-0.183246073298429,0.726315789473684,-0.845140032948929,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.124,-0.993,"9:9","150/150","A:G",14.1489809714057,0.890414731995348,102.692976013979,0.137779442378606,507.712885369765,NA,1.98848253379833,2.1018584548314e-08,7.67739653395739,10.9022485555592,Inf,5.92457926729285e-11,"lineage4","dr_mutations_pyrazinamide","CYS",0,"ERR552456","ERR552456","lineage4.1.1.1","sz","Swaziland","pnca_p.gly97cys","A","-","GLY","GA97","pnca_complex.pdb"
|
|
"G97C","L4","PZA","G","G97",97,"C",1,"MDR","DM","hydrophobic","hydrophobic","neutral","neutral","non-polar","non-polar",8.236,-1.158,-1.635,4.47159,-1.484,-0.7,69,80,-1.026,9,9,7,0.0673076923076923,"loop",-0.833333333333333,4.92,0.0007187005893344,97.3828619670747,1395803.74890115,Inf,42.8452490786805,-10,-2,0,0,-2,0,0,0,0,0,0,2,-2,0,0,0,0,-9,0,-3,-11,-8,0,-7,-21,-0.293313069908815,-0.422480620155039,0.162865041266326,-0.253026427962489,-0.183246073298429,0.726315789473684,-0.845140032948929,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.124,-0.993,"9:9","150/150","A:G",14.1489809714057,0.890414731995348,102.692976013979,0.137779442378606,507.712885369765,NA,1.98848253379833,2.1018584548314e-08,7.67739653395739,10.9022485555592,Inf,5.92457926729285e-11,"lineage4","dr_mutations_pyrazinamide","CYS",0,"ERR553002","ERR553002","lineage4.1.1.1","sz","Swaziland","pnca_p.gly97cys","A","-","GLY","GA97","pnca_complex.pdb"
|
|
"G97D","L3;L4","PZA","G","G97",97,"D",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","neutral","acidic","non-polar","neg",8.236,-0.248,-2.974,12.1049,-2.263,-1.49,83,91,-1.026,9,9,7,0.0673076923076923,"loop",-0.833333333333333,4.92,0.0025154520626706,29.4508301404853,29.4508186631222,29.4177544871982,111.74678026952,-16,-66,0,0,-66,0,0,0,0,-6,0,0,-6,0,0,0,0,-13,0,-9,-13,-8,0,-15,-23,-0.0628166160081053,-0.768475452196382,0.440886807159143,-0.385848252344416,-0.390052356020942,0.873684210526316,-0.845140032948929,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.124,-0.993,"9:9","150/150","A:G",3.38272170811945,2.59985209607615e-12,0.483396852654822,6.9978149206837,12.4656214812387,86.4946048523286,1.46909754090074,1.11009505519018e-18,17.9546398318646,11.2940206861184,97.32420575844,4.05989172191837e-26,"lineage3;lineage4","dr_mutations_pyrazinamide","ASP",0,"ERR1035046","ERR1035046","lineage4.7;lineage3","za","South Africa","pnca_p.gly97asp","A","-","GLY","GA97","pnca_complex.pdb"
|
|
"G97D","L1","PZA","G","G97",97,"D",NA,"MDR","DM","hydrophobic","hydrophilic","neutral","acidic","non-polar","neg",8.236,-0.248,-2.974,12.1049,-2.263,-1.49,83,91,-1.026,9,9,7,0.0673076923076923,"loop",-0.833333333333333,4.92,0.0025154520626706,29.4508301404853,29.4508186631222,29.4177544871982,111.74678026952,-16,-66,0,0,-66,0,0,0,0,-6,0,0,-6,0,0,0,0,-13,0,-9,-13,-8,0,-15,-23,-0.0628166160081053,-0.768475452196382,0.440886807159143,-0.385848252344416,-0.390052356020942,0.873684210526316,-0.845140032948929,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.124,-0.993,"9:9","150/150","A:G",3.38272170811945,2.59985209607615e-12,0.483396852654822,6.9978149206837,12.4656214812387,86.4946048523286,1.46909754090074,1.11009505519018e-18,17.9546398318646,11.2940206861184,97.32420575844,4.05989172191837e-26,"lineage1","dr_mutations_pyrazinamide","ASP",0,"ERR2515514","ERR2515514","lineage1.2.2","za","South Africa","pnca_p.gly97asp","A","-","GLY","GA97","pnca_complex.pdb"
|
|
"G97D","L1","PZA","G","G97",97,"D",0,"MDR","DM","hydrophobic","hydrophilic","neutral","acidic","non-polar","neg",8.236,-0.248,-2.974,12.1049,-2.263,-1.49,83,91,-1.026,9,9,7,0.0673076923076923,"loop",-0.833333333333333,4.92,0.0025154520626706,29.4508301404853,29.4508186631222,29.4177544871982,111.74678026952,-16,-66,0,0,-66,0,0,0,0,-6,0,0,-6,0,0,0,0,-13,0,-9,-13,-8,0,-15,-23,-0.0628166160081053,-0.768475452196382,0.440886807159143,-0.385848252344416,-0.390052356020942,0.873684210526316,-0.845140032948929,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.124,-0.993,"9:9","150/150","A:G",3.38272170811945,2.59985209607615e-12,0.483396852654822,6.9978149206837,12.4656214812387,86.4946048523286,1.46909754090074,1.11009505519018e-18,17.9546398318646,11.2940206861184,97.32420575844,4.05989172191837e-26,"lineage1","dr_mutations_pyrazinamide","ASP",0,"ERR2515648","ERR2515648","lineage1.2.2","za","South Africa","pnca_p.gly97asp","A","-","GLY","GA97","pnca_complex.pdb"
|
|
"G97D","L1","PZA","G","G97",97,"D",1,"MDR","DM","hydrophobic","hydrophilic","neutral","acidic","non-polar","neg",8.236,-0.248,-2.974,12.1049,-2.263,-1.49,83,91,-1.026,9,9,7,0.0673076923076923,"loop",-0.833333333333333,4.92,0.0025154520626706,29.4508301404853,29.4508186631222,29.4177544871982,111.74678026952,-16,-66,0,0,-66,0,0,0,0,-6,0,0,-6,0,0,0,0,-13,0,-9,-13,-8,0,-15,-23,-0.0628166160081053,-0.768475452196382,0.440886807159143,-0.385848252344416,-0.390052356020942,0.873684210526316,-0.845140032948929,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.124,-0.993,"9:9","150/150","A:G",3.38272170811945,2.59985209607615e-12,0.483396852654822,6.9978149206837,12.4656214812387,86.4946048523286,1.46909754090074,1.11009505519018e-18,17.9546398318646,11.2940206861184,97.32420575844,4.05989172191837e-26,"lineage1","dr_mutations_pyrazinamide","ASP",0,"ERR2515131","ERR2515131","lineage1.2.2","za","South Africa","pnca_p.gly97asp","A","-","GLY","GA97","pnca_complex.pdb"
|
|
"G97D","L1","PZA","G","G97",97,"D",0,"MDR","DM","hydrophobic","hydrophilic","neutral","acidic","non-polar","neg",8.236,-0.248,-2.974,12.1049,-2.263,-1.49,83,91,-1.026,9,9,7,0.0673076923076923,"loop",-0.833333333333333,4.92,0.0025154520626706,29.4508301404853,29.4508186631222,29.4177544871982,111.74678026952,-16,-66,0,0,-66,0,0,0,0,-6,0,0,-6,0,0,0,0,-13,0,-9,-13,-8,0,-15,-23,-0.0628166160081053,-0.768475452196382,0.440886807159143,-0.385848252344416,-0.390052356020942,0.873684210526316,-0.845140032948929,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.124,-0.993,"9:9","150/150","A:G",3.38272170811945,2.59985209607615e-12,0.483396852654822,6.9978149206837,12.4656214812387,86.4946048523286,1.46909754090074,1.11009505519018e-18,17.9546398318646,11.2940206861184,97.32420575844,4.05989172191837e-26,"lineage1","dr_mutations_pyrazinamide","ASP",0,"ERR2515749","ERR2515749","lineage1.2.2","za","South Africa","pnca_p.gly97asp","A","-","GLY","GA97","pnca_complex.pdb"
|
|
"G97D","L4","PZA","G","G97",97,"D",NA,"MDR","DM","hydrophobic","hydrophilic","neutral","acidic","non-polar","neg",8.236,-0.248,-2.974,12.1049,-2.263,-1.49,83,91,-1.026,9,9,7,0.0673076923076923,"loop",-0.833333333333333,4.92,0.0025154520626706,29.4508301404853,29.4508186631222,29.4177544871982,111.74678026952,-16,-66,0,0,-66,0,0,0,0,-6,0,0,-6,0,0,0,0,-13,0,-9,-13,-8,0,-15,-23,-0.0628166160081053,-0.768475452196382,0.440886807159143,-0.385848252344416,-0.390052356020942,0.873684210526316,-0.845140032948929,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.124,-0.993,"9:9","150/150","A:G",3.38272170811945,2.59985209607615e-12,0.483396852654822,6.9978149206837,12.4656214812387,86.4946048523286,1.46909754090074,1.11009505519018e-18,17.9546398318646,11.2940206861184,97.32420575844,4.05989172191837e-26,"lineage4","dr_mutations_pyrazinamide","ASP",0,"ERR1034987","ERR1034987","lineage4.7","za","South Africa","pnca_p.gly97asp","A","-","GLY","GA97","pnca_complex.pdb"
|
|
"G97D","L1","PZA","G","G97",97,"D",1,"MDR","DM","hydrophobic","hydrophilic","neutral","acidic","non-polar","neg",8.236,-0.248,-2.974,12.1049,-2.263,-1.49,83,91,-1.026,9,9,7,0.0673076923076923,"loop",-0.833333333333333,4.92,0.0025154520626706,29.4508301404853,29.4508186631222,29.4177544871982,111.74678026952,-16,-66,0,0,-66,0,0,0,0,-6,0,0,-6,0,0,0,0,-13,0,-9,-13,-8,0,-15,-23,-0.0628166160081053,-0.768475452196382,0.440886807159143,-0.385848252344416,-0.390052356020942,0.873684210526316,-0.845140032948929,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.124,-0.993,"9:9","150/150","A:G",3.38272170811945,2.59985209607615e-12,0.483396852654822,6.9978149206837,12.4656214812387,86.4946048523286,1.46909754090074,1.11009505519018e-18,17.9546398318646,11.2940206861184,97.32420575844,4.05989172191837e-26,"lineage1","dr_mutations_pyrazinamide","ASP",0,"ERR552495","ERR552495","lineage1.2.2","sz","Swaziland","pnca_p.gly97asp","A","-","GLY","GA97","pnca_complex.pdb"
|
|
"G97D","L2","PZA","G","G97",97,"D",1,"Pre-XDR","DM","hydrophobic","hydrophilic","neutral","acidic","non-polar","neg",8.236,-0.248,-2.974,12.1049,-2.263,-1.49,83,91,-1.026,9,9,7,0.0673076923076923,"loop",-0.833333333333333,4.92,0.0025154520626706,29.4508301404853,29.4508186631222,29.4177544871982,111.74678026952,-16,-66,0,0,-66,0,0,0,0,-6,0,0,-6,0,0,0,0,-13,0,-9,-13,-8,0,-15,-23,-0.0628166160081053,-0.768475452196382,0.440886807159143,-0.385848252344416,-0.390052356020942,0.873684210526316,-0.845140032948929,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.124,-0.993,"9:9","150/150","A:G",3.38272170811945,2.59985209607615e-12,0.483396852654822,6.9978149206837,12.4656214812387,86.4946048523286,1.46909754090074,1.11009505519018e-18,17.9546398318646,11.2940206861184,97.32420575844,4.05989172191837e-26,"lineage2","dr_mutations_pyrazinamide","ASP",0,"ERR2512882","ERR2512882","lineage2.2.1","gb","UK","pnca_p.gly97asp","A","-","GLY","GA97","pnca_complex.pdb"
|
|
"G97D","L4","PZA","G","G97",97,"D",1,"Pre-XDR","DM","hydrophobic","hydrophilic","neutral","acidic","non-polar","neg",8.236,-0.248,-2.974,12.1049,-2.263,-1.49,83,91,-1.026,9,9,7,0.0673076923076923,"loop",-0.833333333333333,4.92,0.0025154520626706,29.4508301404853,29.4508186631222,29.4177544871982,111.74678026952,-16,-66,0,0,-66,0,0,0,0,-6,0,0,-6,0,0,0,0,-13,0,-9,-13,-8,0,-15,-23,-0.0628166160081053,-0.768475452196382,0.440886807159143,-0.385848252344416,-0.390052356020942,0.873684210526316,-0.845140032948929,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.124,-0.993,"9:9","150/150","A:G",3.38272170811945,2.59985209607615e-12,0.483396852654822,6.9978149206837,12.4656214812387,86.4946048523286,1.46909754090074,1.11009505519018e-18,17.9546398318646,11.2940206861184,97.32420575844,4.05989172191837e-26,"lineage4","dr_mutations_pyrazinamide","ASP",0,"ERR2513831","ERR2513831","lineage4.3.4.2","gb","UK","pnca_p.gly97asp","A","-","GLY","GA97","pnca_complex.pdb"
|
|
"G97D","L4","PZA","G","G97",97,"D",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","neutral","acidic","non-polar","neg",8.236,-0.248,-2.974,12.1049,-2.263,-1.49,83,91,-1.026,9,9,7,0.0673076923076923,"loop",-0.833333333333333,4.92,0.0025154520626706,29.4508301404853,29.4508186631222,29.4177544871982,111.74678026952,-16,-66,0,0,-66,0,0,0,0,-6,0,0,-6,0,0,0,0,-13,0,-9,-13,-8,0,-15,-23,-0.0628166160081053,-0.768475452196382,0.440886807159143,-0.385848252344416,-0.390052356020942,0.873684210526316,-0.845140032948929,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.124,-0.993,"9:9","150/150","A:G",3.38272170811945,2.59985209607615e-12,0.483396852654822,6.9978149206837,12.4656214812387,86.4946048523286,1.46909754090074,1.11009505519018e-18,17.9546398318646,11.2940206861184,97.32420575844,4.05989172191837e-26,"lineage4","dr_mutations_pyrazinamide","ASP",0,"ERR1035080","ERR1035080","lineage4.7","za","South Africa","pnca_p.gly97asp","A","-","GLY","GA97","pnca_complex.pdb"
|
|
"G97D","L1","PZA","G","G97",97,"D",1,"MDR","DM","hydrophobic","hydrophilic","neutral","acidic","non-polar","neg",8.236,-0.248,-2.974,12.1049,-2.263,-1.49,83,91,-1.026,9,9,7,0.0673076923076923,"loop",-0.833333333333333,4.92,0.0025154520626706,29.4508301404853,29.4508186631222,29.4177544871982,111.74678026952,-16,-66,0,0,-66,0,0,0,0,-6,0,0,-6,0,0,0,0,-13,0,-9,-13,-8,0,-15,-23,-0.0628166160081053,-0.768475452196382,0.440886807159143,-0.385848252344416,-0.390052356020942,0.873684210526316,-0.845140032948929,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.124,-0.993,"9:9","150/150","A:G",3.38272170811945,2.59985209607615e-12,0.483396852654822,6.9978149206837,12.4656214812387,86.4946048523286,1.46909754090074,1.11009505519018e-18,17.9546398318646,11.2940206861184,97.32420575844,4.05989172191837e-26,"lineage1","dr_mutations_pyrazinamide","ASP",0,"ERR551920","ERR551920","lineage1.2.2","sz","Swaziland","pnca_p.gly97asp","A","-","GLY","GA97","pnca_complex.pdb"
|
|
"G97D","L1","PZA","G","G97",97,"D",1,"MDR","DM","hydrophobic","hydrophilic","neutral","acidic","non-polar","neg",8.236,-0.248,-2.974,12.1049,-2.263,-1.49,83,91,-1.026,9,9,7,0.0673076923076923,"loop",-0.833333333333333,4.92,0.0025154520626706,29.4508301404853,29.4508186631222,29.4177544871982,111.74678026952,-16,-66,0,0,-66,0,0,0,0,-6,0,0,-6,0,0,0,0,-13,0,-9,-13,-8,0,-15,-23,-0.0628166160081053,-0.768475452196382,0.440886807159143,-0.385848252344416,-0.390052356020942,0.873684210526316,-0.845140032948929,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.124,-0.993,"9:9","150/150","A:G",3.38272170811945,2.59985209607615e-12,0.483396852654822,6.9978149206837,12.4656214812387,86.4946048523286,1.46909754090074,1.11009505519018e-18,17.9546398318646,11.2940206861184,97.32420575844,4.05989172191837e-26,"lineage1","dr_mutations_pyrazinamide","ASP",0,"ERR2515252","ERR2515252","lineage1.2.2","za","South Africa","pnca_p.gly97asp","A","-","GLY","GA97","pnca_complex.pdb"
|
|
"G97D","L4","PZA","G","G97",97,"D",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","neutral","acidic","non-polar","neg",8.236,-0.248,-2.974,12.1049,-2.263,-1.49,83,91,-1.026,9,9,7,0.0673076923076923,"loop",-0.833333333333333,4.92,0.0025154520626706,29.4508301404853,29.4508186631222,29.4177544871982,111.74678026952,-16,-66,0,0,-66,0,0,0,0,-6,0,0,-6,0,0,0,0,-13,0,-9,-13,-8,0,-15,-23,-0.0628166160081053,-0.768475452196382,0.440886807159143,-0.385848252344416,-0.390052356020942,0.873684210526316,-0.845140032948929,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.124,-0.993,"9:9","150/150","A:G",3.38272170811945,2.59985209607615e-12,0.483396852654822,6.9978149206837,12.4656214812387,86.4946048523286,1.46909754090074,1.11009505519018e-18,17.9546398318646,11.2940206861184,97.32420575844,4.05989172191837e-26,"lineage4","dr_mutations_pyrazinamide","ASP",0,"ERR3276260","ERR3276260","lineage4.3.4.2","nl","Netherlands","pnca_p.gly97asp","A","-","GLY","GA97","pnca_complex.pdb"
|
|
"G97D","L2","PZA","G","G97",97,"D",1,"Pre-XDR","DM","hydrophobic","hydrophilic","neutral","acidic","non-polar","neg",8.236,-0.248,-2.974,12.1049,-2.263,-1.49,83,91,-1.026,9,9,7,0.0673076923076923,"loop",-0.833333333333333,4.92,0.0025154520626706,29.4508301404853,29.4508186631222,29.4177544871982,111.74678026952,-16,-66,0,0,-66,0,0,0,0,-6,0,0,-6,0,0,0,0,-13,0,-9,-13,-8,0,-15,-23,-0.0628166160081053,-0.768475452196382,0.440886807159143,-0.385848252344416,-0.390052356020942,0.873684210526316,-0.845140032948929,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.124,-0.993,"9:9","150/150","A:G",3.38272170811945,2.59985209607615e-12,0.483396852654822,6.9978149206837,12.4656214812387,86.4946048523286,1.46909754090074,1.11009505519018e-18,17.9546398318646,11.2940206861184,97.32420575844,4.05989172191837e-26,"lineage2","dr_mutations_pyrazinamide","ASP",0,"ERR108494,1127B-sc-2011-10-12T14:59:23Z-1289159","ERR108494","lineage2.2.1","ru","Russia,Samara","pnca_p.gly97asp","A","-","GLY","GA97","pnca_complex.pdb"
|
|
"G97D","L3","PZA","G","G97",97,"D",1,"MDR","DM","hydrophobic","hydrophilic","neutral","acidic","non-polar","neg",8.236,-0.248,-2.974,12.1049,-2.263,-1.49,83,91,-1.026,9,9,7,0.0673076923076923,"loop",-0.833333333333333,4.92,0.0025154520626706,29.4508301404853,29.4508186631222,29.4177544871982,111.74678026952,-16,-66,0,0,-66,0,0,0,0,-6,0,0,-6,0,0,0,0,-13,0,-9,-13,-8,0,-15,-23,-0.0628166160081053,-0.768475452196382,0.440886807159143,-0.385848252344416,-0.390052356020942,0.873684210526316,-0.845140032948929,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.124,-0.993,"9:9","150/150","A:G",3.38272170811945,2.59985209607615e-12,0.483396852654822,6.9978149206837,12.4656214812387,86.4946048523286,1.46909754090074,1.11009505519018e-18,17.9546398318646,11.2940206861184,97.32420575844,4.05989172191837e-26,"lineage3","dr_mutations_pyrazinamide","ASP",0,"ERR2516890","ERR2516890","lineage3","gb","UK","pnca_p.gly97asp","A","-","GLY","GA97","pnca_complex.pdb"
|
|
"G97D","L1","PZA","G","G97",97,"D",1,"XDR","DM","hydrophobic","hydrophilic","neutral","acidic","non-polar","neg",8.236,-0.248,-2.974,12.1049,-2.263,-1.49,83,91,-1.026,9,9,7,0.0673076923076923,"loop",-0.833333333333333,4.92,0.0025154520626706,29.4508301404853,29.4508186631222,29.4177544871982,111.74678026952,-16,-66,0,0,-66,0,0,0,0,-6,0,0,-6,0,0,0,0,-13,0,-9,-13,-8,0,-15,-23,-0.0628166160081053,-0.768475452196382,0.440886807159143,-0.385848252344416,-0.390052356020942,0.873684210526316,-0.845140032948929,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.124,-0.993,"9:9","150/150","A:G",3.38272170811945,2.59985209607615e-12,0.483396852654822,6.9978149206837,12.4656214812387,86.4946048523286,1.46909754090074,1.11009505519018e-18,17.9546398318646,11.2940206861184,97.32420575844,4.05989172191837e-26,"lineage1","dr_mutations_pyrazinamide","ASP",0,"ERR2515163","ERR2515163","lineage1.2.2","za","South Africa","pnca_p.gly97asp","A","-","GLY","GA97","pnca_complex.pdb"
|
|
"G97D","L1","PZA","G","G97",97,"D",0,"MDR","DM","hydrophobic","hydrophilic","neutral","acidic","non-polar","neg",8.236,-0.248,-2.974,12.1049,-2.263,-1.49,83,91,-1.026,9,9,7,0.0673076923076923,"loop",-0.833333333333333,4.92,0.0025154520626706,29.4508301404853,29.4508186631222,29.4177544871982,111.74678026952,-16,-66,0,0,-66,0,0,0,0,-6,0,0,-6,0,0,0,0,-13,0,-9,-13,-8,0,-15,-23,-0.0628166160081053,-0.768475452196382,0.440886807159143,-0.385848252344416,-0.390052356020942,0.873684210526316,-0.845140032948929,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.124,-0.993,"9:9","150/150","A:G",3.38272170811945,2.59985209607615e-12,0.483396852654822,6.9978149206837,12.4656214812387,86.4946048523286,1.46909754090074,1.11009505519018e-18,17.9546398318646,11.2940206861184,97.32420575844,4.05989172191837e-26,"lineage1","dr_mutations_pyrazinamide","ASP",0,"SAMN02053802","SRR833126_SRR833019","lineage1.2.2","za","South Africa","pnca_p.gly97asp","A","-","GLY","GA97","pnca_complex.pdb"
|
|
"G97D","L1","PZA","G","G97",97,"D",1,"MDR","DM","hydrophobic","hydrophilic","neutral","acidic","non-polar","neg",8.236,-0.248,-2.974,12.1049,-2.263,-1.49,83,91,-1.026,9,9,7,0.0673076923076923,"loop",-0.833333333333333,4.92,0.0025154520626706,29.4508301404853,29.4508186631222,29.4177544871982,111.74678026952,-16,-66,0,0,-66,0,0,0,0,-6,0,0,-6,0,0,0,0,-13,0,-9,-13,-8,0,-15,-23,-0.0628166160081053,-0.768475452196382,0.440886807159143,-0.385848252344416,-0.390052356020942,0.873684210526316,-0.845140032948929,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.124,-0.993,"9:9","150/150","A:G",3.38272170811945,2.59985209607615e-12,0.483396852654822,6.9978149206837,12.4656214812387,86.4946048523286,1.46909754090074,1.11009505519018e-18,17.9546398318646,11.2940206861184,97.32420575844,4.05989172191837e-26,"lineage1","dr_mutations_pyrazinamide","ASP",0,"ERR553321","ERR553321","lineage1.2.2","sz","Swaziland","pnca_p.gly97asp","A","-","GLY","GA97","pnca_complex.pdb"
|
|
"G97D","L4","PZA","G","G97",97,"D",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","neutral","acidic","non-polar","neg",8.236,-0.248,-2.974,12.1049,-2.263,-1.49,83,91,-1.026,9,9,7,0.0673076923076923,"loop",-0.833333333333333,4.92,0.0025154520626706,29.4508301404853,29.4508186631222,29.4177544871982,111.74678026952,-16,-66,0,0,-66,0,0,0,0,-6,0,0,-6,0,0,0,0,-13,0,-9,-13,-8,0,-15,-23,-0.0628166160081053,-0.768475452196382,0.440886807159143,-0.385848252344416,-0.390052356020942,0.873684210526316,-0.845140032948929,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.124,-0.993,"9:9","150/150","A:G",3.38272170811945,2.59985209607615e-12,0.483396852654822,6.9978149206837,12.4656214812387,86.4946048523286,1.46909754090074,1.11009505519018e-18,17.9546398318646,11.2940206861184,97.32420575844,4.05989172191837e-26,"lineage4","dr_mutations_pyrazinamide","ASP",0,"ERR1035066","ERR1035066","lineage4.7","za","South Africa","pnca_p.gly97asp","A","-","GLY","GA97","pnca_complex.pdb"
|
|
"G97D","L1","PZA","G","G97",97,"D",1,"MDR","DM","hydrophobic","hydrophilic","neutral","acidic","non-polar","neg",8.236,-0.248,-2.974,12.1049,-2.263,-1.49,83,91,-1.026,9,9,7,0.0673076923076923,"loop",-0.833333333333333,4.92,0.0025154520626706,29.4508301404853,29.4508186631222,29.4177544871982,111.74678026952,-16,-66,0,0,-66,0,0,0,0,-6,0,0,-6,0,0,0,0,-13,0,-9,-13,-8,0,-15,-23,-0.0628166160081053,-0.768475452196382,0.440886807159143,-0.385848252344416,-0.390052356020942,0.873684210526316,-0.845140032948929,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.124,-0.993,"9:9","150/150","A:G",3.38272170811945,2.59985209607615e-12,0.483396852654822,6.9978149206837,12.4656214812387,86.4946048523286,1.46909754090074,1.11009505519018e-18,17.9546398318646,11.2940206861184,97.32420575844,4.05989172191837e-26,"lineage1","dr_mutations_pyrazinamide","ASP",0,"ERR2516929","ERR2516929","lineage1.2.2","gb","UK","pnca_p.gly97asp","A","-","GLY","GA97","pnca_complex.pdb"
|
|
"G97D","L1","PZA","G","G97",97,"D",1,"MDR","DM","hydrophobic","hydrophilic","neutral","acidic","non-polar","neg",8.236,-0.248,-2.974,12.1049,-2.263,-1.49,83,91,-1.026,9,9,7,0.0673076923076923,"loop",-0.833333333333333,4.92,0.0025154520626706,29.4508301404853,29.4508186631222,29.4177544871982,111.74678026952,-16,-66,0,0,-66,0,0,0,0,-6,0,0,-6,0,0,0,0,-13,0,-9,-13,-8,0,-15,-23,-0.0628166160081053,-0.768475452196382,0.440886807159143,-0.385848252344416,-0.390052356020942,0.873684210526316,-0.845140032948929,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.124,-0.993,"9:9","150/150","A:G",3.38272170811945,2.59985209607615e-12,0.483396852654822,6.9978149206837,12.4656214812387,86.4946048523286,1.46909754090074,1.11009505519018e-18,17.9546398318646,11.2940206861184,97.32420575844,4.05989172191837e-26,"lineage1","dr_mutations_pyrazinamide","ASP",0,"ERR2515342","ERR2515342","lineage1.2.2","za","South Africa","pnca_p.gly97asp","A","-","GLY","GA97","pnca_complex.pdb"
|
|
"G97D","L1","PZA","G","G97",97,"D",NA,"XDR","DM","hydrophobic","hydrophilic","neutral","acidic","non-polar","neg",8.236,-0.248,-2.974,12.1049,-2.263,-1.49,83,91,-1.026,9,9,7,0.0673076923076923,"loop",-0.833333333333333,4.92,0.0025154520626706,29.4508301404853,29.4508186631222,29.4177544871982,111.74678026952,-16,-66,0,0,-66,0,0,0,0,-6,0,0,-6,0,0,0,0,-13,0,-9,-13,-8,0,-15,-23,-0.0628166160081053,-0.768475452196382,0.440886807159143,-0.385848252344416,-0.390052356020942,0.873684210526316,-0.845140032948929,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.124,-0.993,"9:9","150/150","A:G",3.38272170811945,2.59985209607615e-12,0.483396852654822,6.9978149206837,12.4656214812387,86.4946048523286,1.46909754090074,1.11009505519018e-18,17.9546398318646,11.2940206861184,97.32420575844,4.05989172191837e-26,"lineage1","dr_mutations_pyrazinamide","ASP",0,"ERR2515802","ERR2515802","lineage1.2.2","za","South Africa","pnca_p.gly97asp","A","-","GLY","GA97","pnca_complex.pdb"
|
|
"G97D","L4","PZA","G","G97",97,"D",1,"Pre-XDR","DM","hydrophobic","hydrophilic","neutral","acidic","non-polar","neg",8.236,-0.248,-2.974,12.1049,-2.263,-1.49,83,91,-1.026,9,9,7,0.0673076923076923,"loop",-0.833333333333333,4.92,0.0025154520626706,29.4508301404853,29.4508186631222,29.4177544871982,111.74678026952,-16,-66,0,0,-66,0,0,0,0,-6,0,0,-6,0,0,0,0,-13,0,-9,-13,-8,0,-15,-23,-0.0628166160081053,-0.768475452196382,0.440886807159143,-0.385848252344416,-0.390052356020942,0.873684210526316,-0.845140032948929,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.124,-0.993,"9:9","150/150","A:G",3.38272170811945,2.59985209607615e-12,0.483396852654822,6.9978149206837,12.4656214812387,86.4946048523286,1.46909754090074,1.11009505519018e-18,17.9546398318646,11.2940206861184,97.32420575844,4.05989172191837e-26,"lineage4","dr_mutations_pyrazinamide","ASP",0,"ERR2513656","ERR2513656","lineage4.3.4.2","gb","UK","pnca_p.gly97asp","A","-","GLY","GA97","pnca_complex.pdb"
|
|
"G97D","L1","PZA","G","G97",97,"D",1,"MDR","DM","hydrophobic","hydrophilic","neutral","acidic","non-polar","neg",8.236,-0.248,-2.974,12.1049,-2.263,-1.49,83,91,-1.026,9,9,7,0.0673076923076923,"loop",-0.833333333333333,4.92,0.0025154520626706,29.4508301404853,29.4508186631222,29.4177544871982,111.74678026952,-16,-66,0,0,-66,0,0,0,0,-6,0,0,-6,0,0,0,0,-13,0,-9,-13,-8,0,-15,-23,-0.0628166160081053,-0.768475452196382,0.440886807159143,-0.385848252344416,-0.390052356020942,0.873684210526316,-0.845140032948929,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.124,-0.993,"9:9","150/150","A:G",3.38272170811945,2.59985209607615e-12,0.483396852654822,6.9978149206837,12.4656214812387,86.4946048523286,1.46909754090074,1.11009505519018e-18,17.9546398318646,11.2940206861184,97.32420575844,4.05989172191837e-26,"lineage1","dr_mutations_pyrazinamide","ASP",0,"ERR2515465","ERR2515465","lineage1.2.2","za","South Africa","pnca_p.gly97asp","A","-","GLY","GA97","pnca_complex.pdb"
|
|
"G97D","L1","PZA","G","G97",97,"D",NA,"MDR","DM","hydrophobic","hydrophilic","neutral","acidic","non-polar","neg",8.236,-0.248,-2.974,12.1049,-2.263,-1.49,83,91,-1.026,9,9,7,0.0673076923076923,"loop",-0.833333333333333,4.92,0.0025154520626706,29.4508301404853,29.4508186631222,29.4177544871982,111.74678026952,-16,-66,0,0,-66,0,0,0,0,-6,0,0,-6,0,0,0,0,-13,0,-9,-13,-8,0,-15,-23,-0.0628166160081053,-0.768475452196382,0.440886807159143,-0.385848252344416,-0.390052356020942,0.873684210526316,-0.845140032948929,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.124,-0.993,"9:9","150/150","A:G",3.38272170811945,2.59985209607615e-12,0.483396852654822,6.9978149206837,12.4656214812387,86.4946048523286,1.46909754090074,1.11009505519018e-18,17.9546398318646,11.2940206861184,97.32420575844,4.05989172191837e-26,"lineage1","dr_mutations_pyrazinamide","ASP",0,"SAMN01828251","SRR832989_SRR833071_SRR833089_SRR832992_SRR833157","lineage1.2.2","za","South Africa","pnca_p.gly97asp","A","-","GLY","GA97","pnca_complex.pdb"
|
|
"G97D","L4","PZA","G","G97",97,"D",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","neutral","acidic","non-polar","neg",8.236,-0.248,-2.974,12.1049,-2.263,-1.49,83,91,-1.026,9,9,7,0.0673076923076923,"loop",-0.833333333333333,4.92,0.0025154520626706,29.4508301404853,29.4508186631222,29.4177544871982,111.74678026952,-16,-66,0,0,-66,0,0,0,0,-6,0,0,-6,0,0,0,0,-13,0,-9,-13,-8,0,-15,-23,-0.0628166160081053,-0.768475452196382,0.440886807159143,-0.385848252344416,-0.390052356020942,0.873684210526316,-0.845140032948929,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.124,-0.993,"9:9","150/150","A:G",3.38272170811945,2.59985209607615e-12,0.483396852654822,6.9978149206837,12.4656214812387,86.4946048523286,1.46909754090074,1.11009505519018e-18,17.9546398318646,11.2940206861184,97.32420575844,4.05989172191837e-26,"lineage4","dr_mutations_pyrazinamide","ASP",0,"ERR3276264","ERR3276264","lineage4.3.4.2","nl","Netherlands","pnca_p.gly97asp","A","-","GLY","GA97","pnca_complex.pdb"
|
|
"G97D","L4","PZA","G","G97",97,"D",NA,"MDR","DM","hydrophobic","hydrophilic","neutral","acidic","non-polar","neg",8.236,-0.248,-2.974,12.1049,-2.263,-1.49,83,91,-1.026,9,9,7,0.0673076923076923,"loop",-0.833333333333333,4.92,0.0025154520626706,29.4508301404853,29.4508186631222,29.4177544871982,111.74678026952,-16,-66,0,0,-66,0,0,0,0,-6,0,0,-6,0,0,0,0,-13,0,-9,-13,-8,0,-15,-23,-0.0628166160081053,-0.768475452196382,0.440886807159143,-0.385848252344416,-0.390052356020942,0.873684210526316,-0.845140032948929,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.124,-0.993,"9:9","150/150","A:G",3.38272170811945,2.59985209607615e-12,0.483396852654822,6.9978149206837,12.4656214812387,86.4946048523286,1.46909754090074,1.11009505519018e-18,17.9546398318646,11.2940206861184,97.32420575844,4.05989172191837e-26,"lineage4","dr_mutations_pyrazinamide","ASP",0,"ERR1035292","ERR1035292","lineage4.3.2","br","Brazil","pnca_p.gly97asp","A","-","GLY","GA97","pnca_complex.pdb"
|
|
"G97D","L1","PZA","G","G97",97,"D",1,"MDR","DM","hydrophobic","hydrophilic","neutral","acidic","non-polar","neg",8.236,-0.248,-2.974,12.1049,-2.263,-1.49,83,91,-1.026,9,9,7,0.0673076923076923,"loop",-0.833333333333333,4.92,0.0025154520626706,29.4508301404853,29.4508186631222,29.4177544871982,111.74678026952,-16,-66,0,0,-66,0,0,0,0,-6,0,0,-6,0,0,0,0,-13,0,-9,-13,-8,0,-15,-23,-0.0628166160081053,-0.768475452196382,0.440886807159143,-0.385848252344416,-0.390052356020942,0.873684210526316,-0.845140032948929,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.124,-0.993,"9:9","150/150","A:G",3.38272170811945,2.59985209607615e-12,0.483396852654822,6.9978149206837,12.4656214812387,86.4946048523286,1.46909754090074,1.11009505519018e-18,17.9546398318646,11.2940206861184,97.32420575844,4.05989172191837e-26,"lineage1","dr_mutations_pyrazinamide","ASP",0,"ERR2515249","ERR2515249","lineage1.2.2","za","South Africa","pnca_p.gly97asp","A","-","GLY","GA97","pnca_complex.pdb"
|
|
"G97D","L4","PZA","G","G97",97,"D",1,"Pre-XDR","DM","hydrophobic","hydrophilic","neutral","acidic","non-polar","neg",8.236,-0.248,-2.974,12.1049,-2.263,-1.49,83,91,-1.026,9,9,7,0.0673076923076923,"loop",-0.833333333333333,4.92,0.0025154520626706,29.4508301404853,29.4508186631222,29.4177544871982,111.74678026952,-16,-66,0,0,-66,0,0,0,0,-6,0,0,-6,0,0,0,0,-13,0,-9,-13,-8,0,-15,-23,-0.0628166160081053,-0.768475452196382,0.440886807159143,-0.385848252344416,-0.390052356020942,0.873684210526316,-0.845140032948929,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.124,-0.993,"9:9","150/150","A:G",3.38272170811945,2.59985209607615e-12,0.483396852654822,6.9978149206837,12.4656214812387,86.4946048523286,1.46909754090074,1.11009505519018e-18,17.9546398318646,11.2940206861184,97.32420575844,4.05989172191837e-26,"lineage4","dr_mutations_pyrazinamide","ASP",0,"ERR2512975","ERR2512975","lineage4.3.4.2","gb","UK","pnca_p.gly97asp","A","-","GLY","GA97","pnca_complex.pdb"
|
|
"G97D","L2","PZA","G","G97",97,"D",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","neutral","acidic","non-polar","neg",8.236,-0.248,-2.974,12.1049,-2.263,-1.49,83,91,-1.026,9,9,7,0.0673076923076923,"loop",-0.833333333333333,4.92,0.0025154520626706,29.4508301404853,29.4508186631222,29.4177544871982,111.74678026952,-16,-66,0,0,-66,0,0,0,0,-6,0,0,-6,0,0,0,0,-13,0,-9,-13,-8,0,-15,-23,-0.0628166160081053,-0.768475452196382,0.440886807159143,-0.385848252344416,-0.390052356020942,0.873684210526316,-0.845140032948929,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.124,-0.993,"9:9","150/150","A:G",3.38272170811945,2.59985209607615e-12,0.483396852654822,6.9978149206837,12.4656214812387,86.4946048523286,1.46909754090074,1.11009505519018e-18,17.9546398318646,11.2940206861184,97.32420575844,4.05989172191837e-26,"lineage2","dr_mutations_pyrazinamide","ASP",0,"ERR3276263","ERR3276263","lineage2.2.1","nl","Netherlands","pnca_p.gly97asp","A","-","GLY","GA97","pnca_complex.pdb"
|
|
"G97D","L4","PZA","G","G97",97,"D",1,"Pre-XDR","DM","hydrophobic","hydrophilic","neutral","acidic","non-polar","neg",8.236,-0.248,-2.974,12.1049,-2.263,-1.49,83,91,-1.026,9,9,7,0.0673076923076923,"loop",-0.833333333333333,4.92,0.0025154520626706,29.4508301404853,29.4508186631222,29.4177544871982,111.74678026952,-16,-66,0,0,-66,0,0,0,0,-6,0,0,-6,0,0,0,0,-13,0,-9,-13,-8,0,-15,-23,-0.0628166160081053,-0.768475452196382,0.440886807159143,-0.385848252344416,-0.390052356020942,0.873684210526316,-0.845140032948929,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.124,-0.993,"9:9","150/150","A:G",3.38272170811945,2.59985209607615e-12,0.483396852654822,6.9978149206837,12.4656214812387,86.4946048523286,1.46909754090074,1.11009505519018e-18,17.9546398318646,11.2940206861184,97.32420575844,4.05989172191837e-26,"lineage4","dr_mutations_pyrazinamide","ASP",0,"ERR2514487","ERR2514487","lineage4.3.4.2","gb","UK","pnca_p.gly97asp","A","-","GLY","GA97","pnca_complex.pdb"
|
|
"G97D","L1","PZA","G","G97",97,"D",1,"MDR","DM","hydrophobic","hydrophilic","neutral","acidic","non-polar","neg",8.236,-0.248,-2.974,12.1049,-2.263,-1.49,83,91,-1.026,9,9,7,0.0673076923076923,"loop",-0.833333333333333,4.92,0.0025154520626706,29.4508301404853,29.4508186631222,29.4177544871982,111.74678026952,-16,-66,0,0,-66,0,0,0,0,-6,0,0,-6,0,0,0,0,-13,0,-9,-13,-8,0,-15,-23,-0.0628166160081053,-0.768475452196382,0.440886807159143,-0.385848252344416,-0.390052356020942,0.873684210526316,-0.845140032948929,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.124,-0.993,"9:9","150/150","A:G",3.38272170811945,2.59985209607615e-12,0.483396852654822,6.9978149206837,12.4656214812387,86.4946048523286,1.46909754090074,1.11009505519018e-18,17.9546398318646,11.2940206861184,97.32420575844,4.05989172191837e-26,"lineage1","dr_mutations_pyrazinamide","ASP",0,"ERR551319","ERR551319","lineage1.2.2","sz","Swaziland","pnca_p.gly97asp","A","-","GLY","GA97","pnca_complex.pdb"
|
|
"G97D","L4","PZA","G","G97",97,"D",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","neutral","acidic","non-polar","neg",8.236,-0.248,-2.974,12.1049,-2.263,-1.49,83,91,-1.026,9,9,7,0.0673076923076923,"loop",-0.833333333333333,4.92,0.0025154520626706,29.4508301404853,29.4508186631222,29.4177544871982,111.74678026952,-16,-66,0,0,-66,0,0,0,0,-6,0,0,-6,0,0,0,0,-13,0,-9,-13,-8,0,-15,-23,-0.0628166160081053,-0.768475452196382,0.440886807159143,-0.385848252344416,-0.390052356020942,0.873684210526316,-0.845140032948929,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.124,-0.993,"9:9","150/150","A:G",3.38272170811945,2.59985209607615e-12,0.483396852654822,6.9978149206837,12.4656214812387,86.4946048523286,1.46909754090074,1.11009505519018e-18,17.9546398318646,11.2940206861184,97.32420575844,4.05989172191837e-26,"lineage4","dr_mutations_pyrazinamide","ASP",0,"ERR1035030","ERR1035030","lineage4.7","za","South Africa","pnca_p.gly97asp","A","-","GLY","GA97","pnca_complex.pdb"
|
|
"G97D","L2","PZA","G","G97",97,"D",1,"MDR","DM","hydrophobic","hydrophilic","neutral","acidic","non-polar","neg",8.236,-0.248,-2.974,12.1049,-2.263,-1.49,83,91,-1.026,9,9,7,0.0673076923076923,"loop",-0.833333333333333,4.92,0.0025154520626706,29.4508301404853,29.4508186631222,29.4177544871982,111.74678026952,-16,-66,0,0,-66,0,0,0,0,-6,0,0,-6,0,0,0,0,-13,0,-9,-13,-8,0,-15,-23,-0.0628166160081053,-0.768475452196382,0.440886807159143,-0.385848252344416,-0.390052356020942,0.873684210526316,-0.845140032948929,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.124,-0.993,"9:9","150/150","A:G",3.38272170811945,2.59985209607615e-12,0.483396852654822,6.9978149206837,12.4656214812387,86.4946048523286,1.46909754090074,1.11009505519018e-18,17.9546398318646,11.2940206861184,97.32420575844,4.05989172191837e-26,"lineage2","dr_mutations_pyrazinamide","ASP",0,"ERR067705,1469Y-sc-2011-09-07T13:20:05Z-1276552","ERR067705","lineage2.2.1","ru","Russia,Samara","pnca_p.gly97asp","A","-","GLY","GA97","pnca_complex.pdb"
|
|
"G97D","L1","PZA","G","G97",97,"D",1,"MDR","DM","hydrophobic","hydrophilic","neutral","acidic","non-polar","neg",8.236,-0.248,-2.974,12.1049,-2.263,-1.49,83,91,-1.026,9,9,7,0.0673076923076923,"loop",-0.833333333333333,4.92,0.0025154520626706,29.4508301404853,29.4508186631222,29.4177544871982,111.74678026952,-16,-66,0,0,-66,0,0,0,0,-6,0,0,-6,0,0,0,0,-13,0,-9,-13,-8,0,-15,-23,-0.0628166160081053,-0.768475452196382,0.440886807159143,-0.385848252344416,-0.390052356020942,0.873684210526316,-0.845140032948929,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.124,-0.993,"9:9","150/150","A:G",3.38272170811945,2.59985209607615e-12,0.483396852654822,6.9978149206837,12.4656214812387,86.4946048523286,1.46909754090074,1.11009505519018e-18,17.9546398318646,11.2940206861184,97.32420575844,4.05989172191837e-26,"lineage1","dr_mutations_pyrazinamide","ASP",0,"ERS2286404","ERR2503477","lineage1.2.2","fi","Finland","pnca_p.gly97asp","A","-","GLY","GA97","pnca_complex.pdb"
|
|
"G97D","L1","PZA","G","G97",97,"D",1,"MDR","DM","hydrophobic","hydrophilic","neutral","acidic","non-polar","neg",8.236,-0.248,-2.974,12.1049,-2.263,-1.49,83,91,-1.026,9,9,7,0.0673076923076923,"loop",-0.833333333333333,4.92,0.0025154520626706,29.4508301404853,29.4508186631222,29.4177544871982,111.74678026952,-16,-66,0,0,-66,0,0,0,0,-6,0,0,-6,0,0,0,0,-13,0,-9,-13,-8,0,-15,-23,-0.0628166160081053,-0.768475452196382,0.440886807159143,-0.385848252344416,-0.390052356020942,0.873684210526316,-0.845140032948929,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.124,-0.993,"9:9","150/150","A:G",3.38272170811945,2.59985209607615e-12,0.483396852654822,6.9978149206837,12.4656214812387,86.4946048523286,1.46909754090074,1.11009505519018e-18,17.9546398318646,11.2940206861184,97.32420575844,4.05989172191837e-26,"lineage1","dr_mutations_pyrazinamide","ASP",0,"ERR2515798","ERR2515798","lineage1.2.2","za","South Africa","pnca_p.gly97asp","A","-","GLY","GA97","pnca_complex.pdb"
|
|
"G97D","L1","PZA","G","G97",97,"D",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","neutral","acidic","non-polar","neg",8.236,-0.248,-2.974,12.1049,-2.263,-1.49,83,91,-1.026,9,9,7,0.0673076923076923,"loop",-0.833333333333333,4.92,0.0025154520626706,29.4508301404853,29.4508186631222,29.4177544871982,111.74678026952,-16,-66,0,0,-66,0,0,0,0,-6,0,0,-6,0,0,0,0,-13,0,-9,-13,-8,0,-15,-23,-0.0628166160081053,-0.768475452196382,0.440886807159143,-0.385848252344416,-0.390052356020942,0.873684210526316,-0.845140032948929,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.124,-0.993,"9:9","150/150","A:G",3.38272170811945,2.59985209607615e-12,0.483396852654822,6.9978149206837,12.4656214812387,86.4946048523286,1.46909754090074,1.11009505519018e-18,17.9546398318646,11.2940206861184,97.32420575844,4.05989172191837e-26,"lineage1","dr_mutations_pyrazinamide","ASP",0,"SAMN02586077","SRR1184025_SRR1181146_SRR1180415_SRR1180359","lineage1.2.2","za","South Africa","pnca_p.gly97asp","A","-","GLY","GA97","pnca_complex.pdb"
|
|
"G97D","L1","PZA","G","G97",97,"D",NA,"MDR","DM","hydrophobic","hydrophilic","neutral","acidic","non-polar","neg",8.236,-0.248,-2.974,12.1049,-2.263,-1.49,83,91,-1.026,9,9,7,0.0673076923076923,"loop",-0.833333333333333,4.92,0.0025154520626706,29.4508301404853,29.4508186631222,29.4177544871982,111.74678026952,-16,-66,0,0,-66,0,0,0,0,-6,0,0,-6,0,0,0,0,-13,0,-9,-13,-8,0,-15,-23,-0.0628166160081053,-0.768475452196382,0.440886807159143,-0.385848252344416,-0.390052356020942,0.873684210526316,-0.845140032948929,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.124,-0.993,"9:9","150/150","A:G",3.38272170811945,2.59985209607615e-12,0.483396852654822,6.9978149206837,12.4656214812387,86.4946048523286,1.46909754090074,1.11009505519018e-18,17.9546398318646,11.2940206861184,97.32420575844,4.05989172191837e-26,"lineage1","dr_mutations_pyrazinamide","ASP",0,"SAMN02586055","SRR1175063_SRR1184322_SRR1196522_SRR1172864","lineage1.2.2","za","South Africa","pnca_p.gly97asp","A","-","GLY","GA97","pnca_complex.pdb"
|
|
"G97D","L1","PZA","G","G97",97,"D",1,"MDR","DM","hydrophobic","hydrophilic","neutral","acidic","non-polar","neg",8.236,-0.248,-2.974,12.1049,-2.263,-1.49,83,91,-1.026,9,9,7,0.0673076923076923,"loop",-0.833333333333333,4.92,0.0025154520626706,29.4508301404853,29.4508186631222,29.4177544871982,111.74678026952,-16,-66,0,0,-66,0,0,0,0,-6,0,0,-6,0,0,0,0,-13,0,-9,-13,-8,0,-15,-23,-0.0628166160081053,-0.768475452196382,0.440886807159143,-0.385848252344416,-0.390052356020942,0.873684210526316,-0.845140032948929,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.124,-0.993,"9:9","150/150","A:G",3.38272170811945,2.59985209607615e-12,0.483396852654822,6.9978149206837,12.4656214812387,86.4946048523286,1.46909754090074,1.11009505519018e-18,17.9546398318646,11.2940206861184,97.32420575844,4.05989172191837e-26,"lineage1","dr_mutations_pyrazinamide","ASP",0,"ERR553134","ERR553134","lineage1.2.2","sz","Swaziland","pnca_p.gly97asp","A","-","GLY","GA97","pnca_complex.pdb"
|
|
"G97D","L1","PZA","G","G97",97,"D",1,"MDR","DM","hydrophobic","hydrophilic","neutral","acidic","non-polar","neg",8.236,-0.248,-2.974,12.1049,-2.263,-1.49,83,91,-1.026,9,9,7,0.0673076923076923,"loop",-0.833333333333333,4.92,0.0025154520626706,29.4508301404853,29.4508186631222,29.4177544871982,111.74678026952,-16,-66,0,0,-66,0,0,0,0,-6,0,0,-6,0,0,0,0,-13,0,-9,-13,-8,0,-15,-23,-0.0628166160081053,-0.768475452196382,0.440886807159143,-0.385848252344416,-0.390052356020942,0.873684210526316,-0.845140032948929,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.124,-0.993,"9:9","150/150","A:G",3.38272170811945,2.59985209607615e-12,0.483396852654822,6.9978149206837,12.4656214812387,86.4946048523286,1.46909754090074,1.11009505519018e-18,17.9546398318646,11.2940206861184,97.32420575844,4.05989172191837e-26,"lineage1","dr_mutations_pyrazinamide","ASP",0,"SAMN03649010,SRR2101763","SRR2101763","lineage1.2.2","","","pnca_p.gly97asp","A","-","GLY","GA97","pnca_complex.pdb"
|
|
"G97D","L1","PZA","G","G97",97,"D",NA,"MDR","DM","hydrophobic","hydrophilic","neutral","acidic","non-polar","neg",8.236,-0.248,-2.974,12.1049,-2.263,-1.49,83,91,-1.026,9,9,7,0.0673076923076923,"loop",-0.833333333333333,4.92,0.0025154520626706,29.4508301404853,29.4508186631222,29.4177544871982,111.74678026952,-16,-66,0,0,-66,0,0,0,0,-6,0,0,-6,0,0,0,0,-13,0,-9,-13,-8,0,-15,-23,-0.0628166160081053,-0.768475452196382,0.440886807159143,-0.385848252344416,-0.390052356020942,0.873684210526316,-0.845140032948929,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.124,-0.993,"9:9","150/150","A:G",3.38272170811945,2.59985209607615e-12,0.483396852654822,6.9978149206837,12.4656214812387,86.4946048523286,1.46909754090074,1.11009505519018e-18,17.9546398318646,11.2940206861184,97.32420575844,4.05989172191837e-26,"lineage1","dr_mutations_pyrazinamide","ASP",0,"SAMN02585975","SRR1181261_SRR1180341_SRR1180437_SRR1181296","lineage1.2.2","za","South Africa","pnca_p.gly97asp","A","-","GLY","GA97","pnca_complex.pdb"
|
|
"G97D","L1","PZA","G","G97",97,"D",1,"MDR","DM","hydrophobic","hydrophilic","neutral","acidic","non-polar","neg",8.236,-0.248,-2.974,12.1049,-2.263,-1.49,83,91,-1.026,9,9,7,0.0673076923076923,"loop",-0.833333333333333,4.92,0.0025154520626706,29.4508301404853,29.4508186631222,29.4177544871982,111.74678026952,-16,-66,0,0,-66,0,0,0,0,-6,0,0,-6,0,0,0,0,-13,0,-9,-13,-8,0,-15,-23,-0.0628166160081053,-0.768475452196382,0.440886807159143,-0.385848252344416,-0.390052356020942,0.873684210526316,-0.845140032948929,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.124,-0.993,"9:9","150/150","A:G",3.38272170811945,2.59985209607615e-12,0.483396852654822,6.9978149206837,12.4656214812387,86.4946048523286,1.46909754090074,1.11009505519018e-18,17.9546398318646,11.2940206861184,97.32420575844,4.05989172191837e-26,"lineage1","dr_mutations_pyrazinamide","ASP",0,"SRR2100352,SAMN03647525","SRR2100352","lineage1.2.2","","","pnca_p.gly97asp","A","-","GLY","GA97","pnca_complex.pdb"
|
|
"G97D","L1","PZA","G","G97",97,"D",1,"MDR","DM","hydrophobic","hydrophilic","neutral","acidic","non-polar","neg",8.236,-0.248,-2.974,12.1049,-2.263,-1.49,83,91,-1.026,9,9,7,0.0673076923076923,"loop",-0.833333333333333,4.92,0.0025154520626706,29.4508301404853,29.4508186631222,29.4177544871982,111.74678026952,-16,-66,0,0,-66,0,0,0,0,-6,0,0,-6,0,0,0,0,-13,0,-9,-13,-8,0,-15,-23,-0.0628166160081053,-0.768475452196382,0.440886807159143,-0.385848252344416,-0.390052356020942,0.873684210526316,-0.845140032948929,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.124,-0.993,"9:9","150/150","A:G",3.38272170811945,2.59985209607615e-12,0.483396852654822,6.9978149206837,12.4656214812387,86.4946048523286,1.46909754090074,1.11009505519018e-18,17.9546398318646,11.2940206861184,97.32420575844,4.05989172191837e-26,"lineage1","dr_mutations_pyrazinamide","ASP",0,"ERR2515777","ERR2515777","lineage1.2.2","za","South Africa","pnca_p.gly97asp","A","-","GLY","GA97","pnca_complex.pdb"
|
|
"G97D","L4","PZA","G","G97",97,"D",NA,"MDR","DM","hydrophobic","hydrophilic","neutral","acidic","non-polar","neg",8.236,-0.248,-2.974,12.1049,-2.263,-1.49,83,91,-1.026,9,9,7,0.0673076923076923,"loop",-0.833333333333333,4.92,0.0025154520626706,29.4508301404853,29.4508186631222,29.4177544871982,111.74678026952,-16,-66,0,0,-66,0,0,0,0,-6,0,0,-6,0,0,0,0,-13,0,-9,-13,-8,0,-15,-23,-0.0628166160081053,-0.768475452196382,0.440886807159143,-0.385848252344416,-0.390052356020942,0.873684210526316,-0.845140032948929,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.124,-0.993,"9:9","150/150","A:G",3.38272170811945,2.59985209607615e-12,0.483396852654822,6.9978149206837,12.4656214812387,86.4946048523286,1.46909754090074,1.11009505519018e-18,17.9546398318646,11.2940206861184,97.32420575844,4.05989172191837e-26,"lineage4","dr_mutations_pyrazinamide","ASP",0,"ERR751437","ERR751437","lineage4.3.3","pe","","pnca_p.gly97asp","A","-","GLY","GA97","pnca_complex.pdb"
|
|
"G97D","L4","PZA","G","G97",97,"D",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","neutral","acidic","non-polar","neg",8.236,-0.248,-2.974,12.1049,-2.263,-1.49,83,91,-1.026,9,9,7,0.0673076923076923,"loop",-0.833333333333333,4.92,0.0025154520626706,29.4508301404853,29.4508186631222,29.4177544871982,111.74678026952,-16,-66,0,0,-66,0,0,0,0,-6,0,0,-6,0,0,0,0,-13,0,-9,-13,-8,0,-15,-23,-0.0628166160081053,-0.768475452196382,0.440886807159143,-0.385848252344416,-0.390052356020942,0.873684210526316,-0.845140032948929,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.124,-0.993,"9:9","150/150","A:G",3.38272170811945,2.59985209607615e-12,0.483396852654822,6.9978149206837,12.4656214812387,86.4946048523286,1.46909754090074,1.11009505519018e-18,17.9546398318646,11.2940206861184,97.32420575844,4.05989172191837e-26,"lineage4","dr_mutations_pyrazinamide","ASP",0,"ERR1035083","ERR1035083","lineage4.7","za","South Africa","pnca_p.gly97asp","A","-","GLY","GA97","pnca_complex.pdb"
|
|
"G97D","L4","PZA","G","G97",97,"D",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","neutral","acidic","non-polar","neg",8.236,-0.248,-2.974,12.1049,-2.263,-1.49,83,91,-1.026,9,9,7,0.0673076923076923,"loop",-0.833333333333333,4.92,0.0025154520626706,29.4508301404853,29.4508186631222,29.4177544871982,111.74678026952,-16,-66,0,0,-66,0,0,0,0,-6,0,0,-6,0,0,0,0,-13,0,-9,-13,-8,0,-15,-23,-0.0628166160081053,-0.768475452196382,0.440886807159143,-0.385848252344416,-0.390052356020942,0.873684210526316,-0.845140032948929,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.124,-0.993,"9:9","150/150","A:G",3.38272170811945,2.59985209607615e-12,0.483396852654822,6.9978149206837,12.4656214812387,86.4946048523286,1.46909754090074,1.11009505519018e-18,17.9546398318646,11.2940206861184,97.32420575844,4.05989172191837e-26,"lineage4","dr_mutations_pyrazinamide","ASP",0,"ERR2515971","ERR2515971","lineage4.7","za","South Africa","pnca_p.gly97asp","A","-","GLY","GA97","pnca_complex.pdb"
|
|
"G97D","L2","PZA","G","G97",97,"D",1,"Pre-XDR","DM","hydrophobic","hydrophilic","neutral","acidic","non-polar","neg",8.236,-0.248,-2.974,12.1049,-2.263,-1.49,83,91,-1.026,9,9,7,0.0673076923076923,"loop",-0.833333333333333,4.92,0.0025154520626706,29.4508301404853,29.4508186631222,29.4177544871982,111.74678026952,-16,-66,0,0,-66,0,0,0,0,-6,0,0,-6,0,0,0,0,-13,0,-9,-13,-8,0,-15,-23,-0.0628166160081053,-0.768475452196382,0.440886807159143,-0.385848252344416,-0.390052356020942,0.873684210526316,-0.845140032948929,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.124,-0.993,"9:9","150/150","A:G",3.38272170811945,2.59985209607615e-12,0.483396852654822,6.9978149206837,12.4656214812387,86.4946048523286,1.46909754090074,1.11009505519018e-18,17.9546398318646,11.2940206861184,97.32420575844,4.05989172191837e-26,"lineage2","dr_mutations_pyrazinamide","ASP",0,"ERR2514240","ERR2514240","lineage2.2.1","gb","UK","pnca_p.gly97asp","A","-","GLY","GA97","pnca_complex.pdb"
|
|
"G97D","L1","PZA","G","G97",97,"D",1,"MDR","DM","hydrophobic","hydrophilic","neutral","acidic","non-polar","neg",8.236,-0.248,-2.974,12.1049,-2.263,-1.49,83,91,-1.026,9,9,7,0.0673076923076923,"loop",-0.833333333333333,4.92,0.0025154520626706,29.4508301404853,29.4508186631222,29.4177544871982,111.74678026952,-16,-66,0,0,-66,0,0,0,0,-6,0,0,-6,0,0,0,0,-13,0,-9,-13,-8,0,-15,-23,-0.0628166160081053,-0.768475452196382,0.440886807159143,-0.385848252344416,-0.390052356020942,0.873684210526316,-0.845140032948929,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.124,-0.993,"9:9","150/150","A:G",3.38272170811945,2.59985209607615e-12,0.483396852654822,6.9978149206837,12.4656214812387,86.4946048523286,1.46909754090074,1.11009505519018e-18,17.9546398318646,11.2940206861184,97.32420575844,4.05989172191837e-26,"lineage1","dr_mutations_pyrazinamide","ASP",0,"ERR550754","ERR550754","lineage1.2.2","sz","Swaziland","pnca_p.gly97asp","A","-","GLY","GA97","pnca_complex.pdb"
|
|
"G97D","L1","PZA","G","G97",97,"D",1,"MDR","DM","hydrophobic","hydrophilic","neutral","acidic","non-polar","neg",8.236,-0.248,-2.974,12.1049,-2.263,-1.49,83,91,-1.026,9,9,7,0.0673076923076923,"loop",-0.833333333333333,4.92,0.0025154520626706,29.4508301404853,29.4508186631222,29.4177544871982,111.74678026952,-16,-66,0,0,-66,0,0,0,0,-6,0,0,-6,0,0,0,0,-13,0,-9,-13,-8,0,-15,-23,-0.0628166160081053,-0.768475452196382,0.440886807159143,-0.385848252344416,-0.390052356020942,0.873684210526316,-0.845140032948929,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.124,-0.993,"9:9","150/150","A:G",3.38272170811945,2.59985209607615e-12,0.483396852654822,6.9978149206837,12.4656214812387,86.4946048523286,1.46909754090074,1.11009505519018e-18,17.9546398318646,11.2940206861184,97.32420575844,4.05989172191837e-26,"lineage1","dr_mutations_pyrazinamide","ASP",0,"SRR2101757,SAMN03649004","SRR2101757","lineage1.2.2","","","pnca_p.gly97asp","A","-","GLY","GA97","pnca_complex.pdb"
|
|
"G97D","L1","PZA","G","G97",97,"D",1,"MDR","DM","hydrophobic","hydrophilic","neutral","acidic","non-polar","neg",8.236,-0.248,-2.974,12.1049,-2.263,-1.49,83,91,-1.026,9,9,7,0.0673076923076923,"loop",-0.833333333333333,4.92,0.0025154520626706,29.4508301404853,29.4508186631222,29.4177544871982,111.74678026952,-16,-66,0,0,-66,0,0,0,0,-6,0,0,-6,0,0,0,0,-13,0,-9,-13,-8,0,-15,-23,-0.0628166160081053,-0.768475452196382,0.440886807159143,-0.385848252344416,-0.390052356020942,0.873684210526316,-0.845140032948929,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.124,-0.993,"9:9","150/150","A:G",3.38272170811945,2.59985209607615e-12,0.483396852654822,6.9978149206837,12.4656214812387,86.4946048523286,1.46909754090074,1.11009505519018e-18,17.9546398318646,11.2940206861184,97.32420575844,4.05989172191837e-26,"lineage1","dr_mutations_pyrazinamide","ASP",0,"ERR2516057","ERR2516057","lineage1.2.2","za","South Africa","pnca_p.gly97asp","A","-","GLY","GA97","pnca_complex.pdb"
|
|
"G97D","L1","PZA","G","G97",97,"D",0,"MDR","DM","hydrophobic","hydrophilic","neutral","acidic","non-polar","neg",8.236,-0.248,-2.974,12.1049,-2.263,-1.49,83,91,-1.026,9,9,7,0.0673076923076923,"loop",-0.833333333333333,4.92,0.0025154520626706,29.4508301404853,29.4508186631222,29.4177544871982,111.74678026952,-16,-66,0,0,-66,0,0,0,0,-6,0,0,-6,0,0,0,0,-13,0,-9,-13,-8,0,-15,-23,-0.0628166160081053,-0.768475452196382,0.440886807159143,-0.385848252344416,-0.390052356020942,0.873684210526316,-0.845140032948929,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.124,-0.993,"9:9","150/150","A:G",3.38272170811945,2.59985209607615e-12,0.483396852654822,6.9978149206837,12.4656214812387,86.4946048523286,1.46909754090074,1.11009505519018e-18,17.9546398318646,11.2940206861184,97.32420575844,4.05989172191837e-26,"lineage1","dr_mutations_pyrazinamide","ASP",0,"ERR2515962","ERR2515962","lineage1.2.2","za","South Africa","pnca_p.gly97asp","A","-","GLY","GA97","pnca_complex.pdb"
|
|
"G97D","L1","PZA","G","G97",97,"D",1,"MDR","DM","hydrophobic","hydrophilic","neutral","acidic","non-polar","neg",8.236,-0.248,-2.974,12.1049,-2.263,-1.49,83,91,-1.026,9,9,7,0.0673076923076923,"loop",-0.833333333333333,4.92,0.0025154520626706,29.4508301404853,29.4508186631222,29.4177544871982,111.74678026952,-16,-66,0,0,-66,0,0,0,0,-6,0,0,-6,0,0,0,0,-13,0,-9,-13,-8,0,-15,-23,-0.0628166160081053,-0.768475452196382,0.440886807159143,-0.385848252344416,-0.390052356020942,0.873684210526316,-0.845140032948929,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.124,-0.993,"9:9","150/150","A:G",3.38272170811945,2.59985209607615e-12,0.483396852654822,6.9978149206837,12.4656214812387,86.4946048523286,1.46909754090074,1.11009505519018e-18,17.9546398318646,11.2940206861184,97.32420575844,4.05989172191837e-26,"lineage1","dr_mutations_pyrazinamide","ASP",0,"ERR551329","ERR551329","lineage1.2.2","sz","Swaziland","pnca_p.gly97asp","A","-","GLY","GA97","pnca_complex.pdb"
|
|
"G97D","L1","PZA","G","G97",97,"D",0,"MDR","DM","hydrophobic","hydrophilic","neutral","acidic","non-polar","neg",8.236,-0.248,-2.974,12.1049,-2.263,-1.49,83,91,-1.026,9,9,7,0.0673076923076923,"loop",-0.833333333333333,4.92,0.0025154520626706,29.4508301404853,29.4508186631222,29.4177544871982,111.74678026952,-16,-66,0,0,-66,0,0,0,0,-6,0,0,-6,0,0,0,0,-13,0,-9,-13,-8,0,-15,-23,-0.0628166160081053,-0.768475452196382,0.440886807159143,-0.385848252344416,-0.390052356020942,0.873684210526316,-0.845140032948929,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.124,-0.993,"9:9","150/150","A:G",3.38272170811945,2.59985209607615e-12,0.483396852654822,6.9978149206837,12.4656214812387,86.4946048523286,1.46909754090074,1.11009505519018e-18,17.9546398318646,11.2940206861184,97.32420575844,4.05989172191837e-26,"lineage1","dr_mutations_pyrazinamide","ASP",0,"ERR2515348","ERR2515348","lineage1.2.2","za","South Africa","pnca_p.gly97asp","A","-","GLY","GA97","pnca_complex.pdb"
|
|
"G97R","L2","PZA","G","G97",97,"R",1,"MDR","DM","hydrophobic","hydrophilic","neutral","basic","non-polar","pos",8.236,-0.89,-1.252,4.89479,-2.091,-0.79,82,91,-1.026,9,9,7,0.0673076923076923,"loop",-0.833333333333333,4.92,0.0001437401178668,19.411022297013,511754.463553323,Inf,4.73122070382274,-78,-34,0,0,-34,0,0,0,0,-4,0,0,-6,0,0,0,0,-16,0,-10,-15,-16,0,-13,-27,-0.225430597771023,-0.323514211886305,0.178278906460566,-0.356521739130435,-0.206806282722513,0.863157894736842,-0.845140032948929,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.124,-0.993,"9:9","150/150","A:G",13.1456002256219,0.924803768447043,139.277183326664,0.0943844491368691,0.0001628371344429,NA,1.28804840845689,0.0292235860951597,1.53426649183163,0.91081598550184,Inf,0.0296198560706035,"lineage2","dr_mutations_pyrazinamide","ARG",0,"ERR2517307","ERR2517307","lineage2.2.1","nl","Netherlands","pnca_p.gly97arg","A","-","GLY","GA97","pnca_complex.pdb"
|
|
"G97R","L1","PZA","G","G97",97,"R",1,"MDR","DM","hydrophobic","hydrophilic","neutral","basic","non-polar","pos",8.236,-0.89,-1.252,4.89479,-2.091,-0.79,82,91,-1.026,9,9,7,0.0673076923076923,"loop",-0.833333333333333,4.92,0.0001437401178668,19.411022297013,511754.463553323,Inf,4.73122070382274,-78,-34,0,0,-34,0,0,0,0,-4,0,0,-6,0,0,0,0,-16,0,-10,-15,-16,0,-13,-27,-0.225430597771023,-0.323514211886305,0.178278906460566,-0.356521739130435,-0.206806282722513,0.863157894736842,-0.845140032948929,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.124,-0.993,"9:9","150/150","A:G",13.1456002256219,0.924803768447043,139.277183326664,0.0943844491368691,0.0001628371344429,NA,1.28804840845689,0.0292235860951597,1.53426649183163,0.91081598550184,Inf,0.0296198560706035,"lineage1","dr_mutations_pyrazinamide","ARG",0,"SAMN03649053,SRR2101806","SRR2101806","lineage1.2.2","","","pnca_p.gly97arg","A","-","GLY","GA97","pnca_complex.pdb"
|
|
"G97S","L4","PZA","G","G97",97,"S",NA,"XDR","DM","hydrophobic","hydrophilic","neutral","neutral","non-polar","polar",8.236,-0.309,-1.999,5.99386,-2.075,-1.28,72,85,-1.026,9,9,7,0.0673076923076923,"loop",-0.833333333333333,4.92,0.000646830530401,87.6075949367089,1395214.80217992,Inf,38.0099632572142,-6,0,0,0,0,0,0,0,0,-4,0,-2,-2,0,0,0,0,-7,0,-3,-4,-4,0,-7,-19,-0.0782674772036474,-0.516537467700258,0.21830942824467,-0.353793691389599,-0.335078534031414,0.757894736842105,-0.845140032948929,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.124,-0.993,"9:9","150/150","A:G",14.1485589414412,0.896008552350388,108.247901040098,0.130705157379451,226.474535582214,NA,1.94254175795031,1.23317897951184e-07,6.90897388676731,9.59561062779463,Inf,7.038428913028e-10,"lineage4","dr_mutations_pyrazinamide","SER",0,"ERR688043","ERR688043","lineage4.8","pk","Pakistan","pnca_p.gly97ser","A","-","GLY","GA97","pnca_complex.pdb"
|
|
"G97S","L2","PZA","G","G97",97,"S",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","neutral","neutral","non-polar","polar",8.236,-0.309,-1.999,5.99386,-2.075,-1.28,72,85,-1.026,9,9,7,0.0673076923076923,"loop",-0.833333333333333,4.92,0.000646830530401,87.6075949367089,1395214.80217992,Inf,38.0099632572142,-6,0,0,0,0,0,0,0,0,-4,0,-2,-2,0,0,0,0,-7,0,-3,-4,-4,0,-7,-19,-0.0782674772036474,-0.516537467700258,0.21830942824467,-0.353793691389599,-0.335078534031414,0.757894736842105,-0.845140032948929,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.124,-0.993,"9:9","150/150","A:G",14.1485589414412,0.896008552350388,108.247901040098,0.130705157379451,226.474535582214,NA,1.94254175795031,1.23317897951184e-07,6.90897388676731,9.59561062779463,Inf,7.038428913028e-10,"lineage2","dr_mutations_pyrazinamide","SER",0,"SRR6397748","SRR6397748","lineage2.2.1","ca","Canada","pnca_p.gly97ser","A","-","GLY","GA97","pnca_complex.pdb"
|
|
"G97S","L4","PZA","G","G97",97,"S",1,"XDR","DM","hydrophobic","hydrophilic","neutral","neutral","non-polar","polar",8.236,-0.309,-1.999,5.99386,-2.075,-1.28,72,85,-1.026,9,9,7,0.0673076923076923,"loop",-0.833333333333333,4.92,0.000646830530401,87.6075949367089,1395214.80217992,Inf,38.0099632572142,-6,0,0,0,0,0,0,0,0,-4,0,-2,-2,0,0,0,0,-7,0,-3,-4,-4,0,-7,-19,-0.0782674772036474,-0.516537467700258,0.21830942824467,-0.353793691389599,-0.335078534031414,0.757894736842105,-0.845140032948929,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.124,-0.993,"9:9","150/150","A:G",14.1485589414412,0.896008552350388,108.247901040098,0.130705157379451,226.474535582214,NA,1.94254175795031,1.23317897951184e-07,6.90897388676731,9.59561062779463,Inf,7.038428913028e-10,"lineage4","dr_mutations_pyrazinamide","SER",0,"ERR2516492","ERR2516492","lineage4.3.3","pe","Peru","pnca_p.gly97ser","A","-","GLY","GA97","pnca_complex.pdb"
|
|
"G97S","L4","PZA","G","G97",97,"S",1,"XDR","DM","hydrophobic","hydrophilic","neutral","neutral","non-polar","polar",8.236,-0.309,-1.999,5.99386,-2.075,-1.28,72,85,-1.026,9,9,7,0.0673076923076923,"loop",-0.833333333333333,4.92,0.000646830530401,87.6075949367089,1395214.80217992,Inf,38.0099632572142,-6,0,0,0,0,0,0,0,0,-4,0,-2,-2,0,0,0,0,-7,0,-3,-4,-4,0,-7,-19,-0.0782674772036474,-0.516537467700258,0.21830942824467,-0.353793691389599,-0.335078534031414,0.757894736842105,-0.845140032948929,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.124,-0.993,"9:9","150/150","A:G",14.1485589414412,0.896008552350388,108.247901040098,0.130705157379451,226.474535582214,NA,1.94254175795031,1.23317897951184e-07,6.90897388676731,9.59561062779463,Inf,7.038428913028e-10,"lineage4","dr_mutations_pyrazinamide","SER",0,"ERR2516455","ERR2516455","lineage4.3.3","pe","Peru","pnca_p.gly97ser","A","-","GLY","GA97","pnca_complex.pdb"
|
|
"G97S","L2","PZA","G","G97",97,"S",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","neutral","neutral","non-polar","polar",8.236,-0.309,-1.999,5.99386,-2.075,-1.28,72,85,-1.026,9,9,7,0.0673076923076923,"loop",-0.833333333333333,4.92,0.000646830530401,87.6075949367089,1395214.80217992,Inf,38.0099632572142,-6,0,0,0,0,0,0,0,0,-4,0,-2,-2,0,0,0,0,-7,0,-3,-4,-4,0,-7,-19,-0.0782674772036474,-0.516537467700258,0.21830942824467,-0.353793691389599,-0.335078534031414,0.757894736842105,-0.845140032948929,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.124,-0.993,"9:9","150/150","A:G",14.1485589414412,0.896008552350388,108.247901040098,0.130705157379451,226.474535582214,NA,1.94254175795031,1.23317897951184e-07,6.90897388676731,9.59561062779463,Inf,7.038428913028e-10,"lineage2","dr_mutations_pyrazinamide","SER",0,"SAMN07236255,SRR5709912","SRR5709912","lineage2.2.1","th","Thailand","pnca_p.gly97ser","A","-","GLY","GA97","pnca_complex.pdb"
|
|
"G97S","L2","PZA","G","G97",97,"S",NA,"XDR","DM","hydrophobic","hydrophilic","neutral","neutral","non-polar","polar",8.236,-0.309,-1.999,5.99386,-2.075,-1.28,72,85,-1.026,9,9,7,0.0673076923076923,"loop",-0.833333333333333,4.92,0.000646830530401,87.6075949367089,1395214.80217992,Inf,38.0099632572142,-6,0,0,0,0,0,0,0,0,-4,0,-2,-2,0,0,0,0,-7,0,-3,-4,-4,0,-7,-19,-0.0782674772036474,-0.516537467700258,0.21830942824467,-0.353793691389599,-0.335078534031414,0.757894736842105,-0.845140032948929,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.124,-0.993,"9:9","150/150","A:G",14.1485589414412,0.896008552350388,108.247901040098,0.130705157379451,226.474535582214,NA,1.94254175795031,1.23317897951184e-07,6.90897388676731,9.59561062779463,Inf,7.038428913028e-10,"lineage2","dr_mutations_pyrazinamide","SER",0,"ETB0092","SRR6257024","lineage2.2.1","ru","Russia:Chelyabinsk Region","pnca_p.gly97ser","A","-","GLY","GA97","pnca_complex.pdb"
|
|
"G97S","L2","PZA","G","G97",97,"S",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","neutral","neutral","non-polar","polar",8.236,-0.309,-1.999,5.99386,-2.075,-1.28,72,85,-1.026,9,9,7,0.0673076923076923,"loop",-0.833333333333333,4.92,0.000646830530401,87.6075949367089,1395214.80217992,Inf,38.0099632572142,-6,0,0,0,0,0,0,0,0,-4,0,-2,-2,0,0,0,0,-7,0,-3,-4,-4,0,-7,-19,-0.0782674772036474,-0.516537467700258,0.21830942824467,-0.353793691389599,-0.335078534031414,0.757894736842105,-0.845140032948929,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.124,-0.993,"9:9","150/150","A:G",14.1485589414412,0.896008552350388,108.247901040098,0.130705157379451,226.474535582214,NA,1.94254175795031,1.23317897951184e-07,6.90897388676731,9.59561062779463,Inf,7.038428913028e-10,"lineage2","dr_mutations_pyrazinamide","SER",0,"SAMN02419580","SRR1158923_SRR1181107_SRR1162533_SRR1181311","lineage2.2.1","by","Belarus","pnca_p.gly97ser","A","-","GLY","GA97","pnca_complex.pdb"
|
|
"G97S","L4","PZA","G","G97",97,"S",1,"Pre-XDR","DM","hydrophobic","hydrophilic","neutral","neutral","non-polar","polar",8.236,-0.309,-1.999,5.99386,-2.075,-1.28,72,85,-1.026,9,9,7,0.0673076923076923,"loop",-0.833333333333333,4.92,0.000646830530401,87.6075949367089,1395214.80217992,Inf,38.0099632572142,-6,0,0,0,0,0,0,0,0,-4,0,-2,-2,0,0,0,0,-7,0,-3,-4,-4,0,-7,-19,-0.0782674772036474,-0.516537467700258,0.21830942824467,-0.353793691389599,-0.335078534031414,0.757894736842105,-0.845140032948929,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.124,-0.993,"9:9","150/150","A:G",14.1485589414412,0.896008552350388,108.247901040098,0.130705157379451,226.474535582214,NA,1.94254175795031,1.23317897951184e-07,6.90897388676731,9.59561062779463,Inf,7.038428913028e-10,"lineage4","dr_mutations_pyrazinamide","SER",0,"ERR2516570","ERR2516570","lineage4.3.3","pe","Peru","pnca_p.gly97ser","A","-","GLY","GA97","pnca_complex.pdb"
|
|
"G97S","L2","PZA","G","G97",97,"S",1,"XDR","DM","hydrophobic","hydrophilic","neutral","neutral","non-polar","polar",8.236,-0.309,-1.999,5.99386,-2.075,-1.28,72,85,-1.026,9,9,7,0.0673076923076923,"loop",-0.833333333333333,4.92,0.000646830530401,87.6075949367089,1395214.80217992,Inf,38.0099632572142,-6,0,0,0,0,0,0,0,0,-4,0,-2,-2,0,0,0,0,-7,0,-3,-4,-4,0,-7,-19,-0.0782674772036474,-0.516537467700258,0.21830942824467,-0.353793691389599,-0.335078534031414,0.757894736842105,-0.845140032948929,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.124,-0.993,"9:9","150/150","A:G",14.1485589414412,0.896008552350388,108.247901040098,0.130705157379451,226.474535582214,NA,1.94254175795031,1.23317897951184e-07,6.90897388676731,9.59561062779463,Inf,7.038428913028e-10,"lineage2","dr_mutations_pyrazinamide","SER",0,"ERR133873,0518P-sc-2012-02-09T18:56:15Z-1355206","ERR133873","lineage2.2.1","ru","Russia,Samara","pnca_p.gly97ser","A","-","GLY","GA97","pnca_complex.pdb"
|
|
"G97S","L2","PZA","G","G97",97,"S",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","neutral","neutral","non-polar","polar",8.236,-0.309,-1.999,5.99386,-2.075,-1.28,72,85,-1.026,9,9,7,0.0673076923076923,"loop",-0.833333333333333,4.92,0.000646830530401,87.6075949367089,1395214.80217992,Inf,38.0099632572142,-6,0,0,0,0,0,0,0,0,-4,0,-2,-2,0,0,0,0,-7,0,-3,-4,-4,0,-7,-19,-0.0782674772036474,-0.516537467700258,0.21830942824467,-0.353793691389599,-0.335078534031414,0.757894736842105,-0.845140032948929,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.124,-0.993,"9:9","150/150","A:G",14.1485589414412,0.896008552350388,108.247901040098,0.130705157379451,226.474535582214,NA,1.94254175795031,1.23317897951184e-07,6.90897388676731,9.59561062779463,Inf,7.038428913028e-10,"lineage2","dr_mutations_pyrazinamide","SER",0,"SAMN02360555","SRR1048851_SRR1013552_SRR1048850_SRR1013551","lineage2.2.2","kr","South Korea","pnca_p.gly97ser","A","-","GLY","GA97","pnca_complex.pdb"
|
|
"G97S","L4","PZA","G","G97",97,"S",1,"Pre-XDR","DM","hydrophobic","hydrophilic","neutral","neutral","non-polar","polar",8.236,-0.309,-1.999,5.99386,-2.075,-1.28,72,85,-1.026,9,9,7,0.0673076923076923,"loop",-0.833333333333333,4.92,0.000646830530401,87.6075949367089,1395214.80217992,Inf,38.0099632572142,-6,0,0,0,0,0,0,0,0,-4,0,-2,-2,0,0,0,0,-7,0,-3,-4,-4,0,-7,-19,-0.0782674772036474,-0.516537467700258,0.21830942824467,-0.353793691389599,-0.335078534031414,0.757894736842105,-0.845140032948929,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.124,-0.993,"9:9","150/150","A:G",14.1485589414412,0.896008552350388,108.247901040098,0.130705157379451,226.474535582214,NA,1.94254175795031,1.23317897951184e-07,6.90897388676731,9.59561062779463,Inf,7.038428913028e-10,"lineage4","dr_mutations_pyrazinamide","SER",0,"ETB0042","SRR6257080","lineage4.8","ru","Russia:Vladimir Oblast","pnca_p.gly97ser","A","-","GLY","GA97","pnca_complex.pdb"
|
|
"G97S","L2","PZA","G","G97",97,"S",1,"Pre-XDR","DM","hydrophobic","hydrophilic","neutral","neutral","non-polar","polar",8.236,-0.309,-1.999,5.99386,-2.075,-1.28,72,85,-1.026,9,9,7,0.0673076923076923,"loop",-0.833333333333333,4.92,0.000646830530401,87.6075949367089,1395214.80217992,Inf,38.0099632572142,-6,0,0,0,0,0,0,0,0,-4,0,-2,-2,0,0,0,0,-7,0,-3,-4,-4,0,-7,-19,-0.0782674772036474,-0.516537467700258,0.21830942824467,-0.353793691389599,-0.335078534031414,0.757894736842105,-0.845140032948929,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.124,-0.993,"9:9","150/150","A:G",14.1485589414412,0.896008552350388,108.247901040098,0.130705157379451,226.474535582214,NA,1.94254175795031,1.23317897951184e-07,6.90897388676731,9.59561062779463,Inf,7.038428913028e-10,"lineage2","dr_mutations_pyrazinamide","SER",0,"MDR_12270","SRR6824499","lineage2.2.1","cn","China: Ma'anshan City, Anhui Province","pnca_p.gly97ser","A","-","GLY","GA97","pnca_complex.pdb"
|
|
"G97S","L4","PZA","G","G97",97,"S",NA,"MDR","DM","hydrophobic","hydrophilic","neutral","neutral","non-polar","polar",8.236,-0.309,-1.999,5.99386,-2.075,-1.28,72,85,-1.026,9,9,7,0.0673076923076923,"loop",-0.833333333333333,4.92,0.000646830530401,87.6075949367089,1395214.80217992,Inf,38.0099632572142,-6,0,0,0,0,0,0,0,0,-4,0,-2,-2,0,0,0,0,-7,0,-3,-4,-4,0,-7,-19,-0.0782674772036474,-0.516537467700258,0.21830942824467,-0.353793691389599,-0.335078534031414,0.757894736842105,-0.845140032948929,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.124,-0.993,"9:9","150/150","A:G",14.1485589414412,0.896008552350388,108.247901040098,0.130705157379451,226.474535582214,NA,1.94254175795031,1.23317897951184e-07,6.90897388676731,9.59561062779463,Inf,7.038428913028e-10,"lineage4","dr_mutations_pyrazinamide","SER",0,"ERR779876","ERR779876","lineage4.1.2.1","pe","","pnca_p.gly97ser","A","-","GLY","GA97","pnca_complex.pdb"
|
|
"G97S","L2","PZA","G","G97",97,"S",1,"Pre-XDR","DM","hydrophobic","hydrophilic","neutral","neutral","non-polar","polar",8.236,-0.309,-1.999,5.99386,-2.075,-1.28,72,85,-1.026,9,9,7,0.0673076923076923,"loop",-0.833333333333333,4.92,0.000646830530401,87.6075949367089,1395214.80217992,Inf,38.0099632572142,-6,0,0,0,0,0,0,0,0,-4,0,-2,-2,0,0,0,0,-7,0,-3,-4,-4,0,-7,-19,-0.0782674772036474,-0.516537467700258,0.21830942824467,-0.353793691389599,-0.335078534031414,0.757894736842105,-0.845140032948929,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.124,-0.993,"9:9","150/150","A:G",14.1485589414412,0.896008552350388,108.247901040098,0.130705157379451,226.474535582214,NA,1.94254175795031,1.23317897951184e-07,6.90897388676731,9.59561062779463,Inf,7.038428913028e-10,"lineage2","dr_mutations_pyrazinamide","SER",0,"ERR234688,2592T-sc-2012-10-11T13:41:02Z-1494366","ERR234688","lineage2.2.1","ru","Russia","pnca_p.gly97ser","A","-","GLY","GA97","pnca_complex.pdb"
|
|
"G97S","L2","PZA","G","G97",97,"S",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","neutral","neutral","non-polar","polar",8.236,-0.309,-1.999,5.99386,-2.075,-1.28,72,85,-1.026,9,9,7,0.0673076923076923,"loop",-0.833333333333333,4.92,0.000646830530401,87.6075949367089,1395214.80217992,Inf,38.0099632572142,-6,0,0,0,0,0,0,0,0,-4,0,-2,-2,0,0,0,0,-7,0,-3,-4,-4,0,-7,-19,-0.0782674772036474,-0.516537467700258,0.21830942824467,-0.353793691389599,-0.335078534031414,0.757894736842105,-0.845140032948929,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.124,-0.993,"9:9","150/150","A:G",14.1485589414412,0.896008552350388,108.247901040098,0.130705157379451,226.474535582214,NA,1.94254175795031,1.23317897951184e-07,6.90897388676731,9.59561062779463,Inf,7.038428913028e-10,"lineage2","dr_mutations_pyrazinamide","SER",0,"SRR6397399","SRR6397399","lineage2.2.1","ca","Canada","pnca_p.gly97ser","A","-","GLY","GA97","pnca_complex.pdb"
|
|
"G97S","L4","PZA","G","G97",97,"S",NA,"MDR","DM","hydrophobic","hydrophilic","neutral","neutral","non-polar","polar",8.236,-0.309,-1.999,5.99386,-2.075,-1.28,72,85,-1.026,9,9,7,0.0673076923076923,"loop",-0.833333333333333,4.92,0.000646830530401,87.6075949367089,1395214.80217992,Inf,38.0099632572142,-6,0,0,0,0,0,0,0,0,-4,0,-2,-2,0,0,0,0,-7,0,-3,-4,-4,0,-7,-19,-0.0782674772036474,-0.516537467700258,0.21830942824467,-0.353793691389599,-0.335078534031414,0.757894736842105,-0.845140032948929,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.124,-0.993,"9:9","150/150","A:G",14.1485589414412,0.896008552350388,108.247901040098,0.130705157379451,226.474535582214,NA,1.94254175795031,1.23317897951184e-07,6.90897388676731,9.59561062779463,Inf,7.038428913028e-10,"lineage4","dr_mutations_pyrazinamide","SER",0,"SAMN02567706","SRR1166163","lineage4.1.2.1","ro","Romania","pnca_p.gly97ser","A","-","GLY","GA97","pnca_complex.pdb"
|
|
"G97S","L2","PZA","G","G97",97,"S",1,"MDR","DM","hydrophobic","hydrophilic","neutral","neutral","non-polar","polar",8.236,-0.309,-1.999,5.99386,-2.075,-1.28,72,85,-1.026,9,9,7,0.0673076923076923,"loop",-0.833333333333333,4.92,0.000646830530401,87.6075949367089,1395214.80217992,Inf,38.0099632572142,-6,0,0,0,0,0,0,0,0,-4,0,-2,-2,0,0,0,0,-7,0,-3,-4,-4,0,-7,-19,-0.0782674772036474,-0.516537467700258,0.21830942824467,-0.353793691389599,-0.335078534031414,0.757894736842105,-0.845140032948929,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.124,-0.993,"9:9","150/150","A:G",14.1485589414412,0.896008552350388,108.247901040098,0.130705157379451,226.474535582214,NA,1.94254175795031,1.23317897951184e-07,6.90897388676731,9.59561062779463,Inf,7.038428913028e-10,"lineage2","dr_mutations_pyrazinamide","SER",0,"ERR144608,2007H-sc-2012-02-21T11:38:13Z-1364845","ERR144608","lineage2.2.1","ru","Russia","pnca_p.gly97ser","A","-","GLY","GA97","pnca_complex.pdb"
|
|
"G97S","L4","PZA","G","G97",97,"S",NA,"MDR","DM","hydrophobic","hydrophilic","neutral","neutral","non-polar","polar",8.236,-0.309,-1.999,5.99386,-2.075,-1.28,72,85,-1.026,9,9,7,0.0673076923076923,"loop",-0.833333333333333,4.92,0.000646830530401,87.6075949367089,1395214.80217992,Inf,38.0099632572142,-6,0,0,0,0,0,0,0,0,-4,0,-2,-2,0,0,0,0,-7,0,-3,-4,-4,0,-7,-19,-0.0782674772036474,-0.516537467700258,0.21830942824467,-0.353793691389599,-0.335078534031414,0.757894736842105,-0.845140032948929,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.124,-0.993,"9:9","150/150","A:G",14.1485589414412,0.896008552350388,108.247901040098,0.130705157379451,226.474535582214,NA,1.94254175795031,1.23317897951184e-07,6.90897388676731,9.59561062779463,Inf,7.038428913028e-10,"lineage4","dr_mutations_pyrazinamide","SER",0,"ERR2510133","ERR2510133","lineage4.1.2.1","pe","Peru","pnca_p.gly97ser","A","-","GLY","GA97","pnca_complex.pdb"
|
|
"G97S","L4","PZA","G","G97",97,"S",1,"XDR","DM","hydrophobic","hydrophilic","neutral","neutral","non-polar","polar",8.236,-0.309,-1.999,5.99386,-2.075,-1.28,72,85,-1.026,9,9,7,0.0673076923076923,"loop",-0.833333333333333,4.92,0.000646830530401,87.6075949367089,1395214.80217992,Inf,38.0099632572142,-6,0,0,0,0,0,0,0,0,-4,0,-2,-2,0,0,0,0,-7,0,-3,-4,-4,0,-7,-19,-0.0782674772036474,-0.516537467700258,0.21830942824467,-0.353793691389599,-0.335078534031414,0.757894736842105,-0.845140032948929,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.124,-0.993,"9:9","150/150","A:G",14.1485589414412,0.896008552350388,108.247901040098,0.130705157379451,226.474535582214,NA,1.94254175795031,1.23317897951184e-07,6.90897388676731,9.59561062779463,Inf,7.038428913028e-10,"lineage4","dr_mutations_pyrazinamide","SER",0,"ERR2516619","ERR2516619","lineage4.3.3","pe","Peru","pnca_p.gly97ser","A","-","GLY","GA97","pnca_complex.pdb"
|
|
"G97V","L1","PZA","G","G97",97,"V",NA,"Pre-MDR","OM","hydrophobic","hydrophobic","neutral","non-polar","non-polar","non-polar",8.236,-1.664,-0.588,6.12241,-2.616,-1.24,77,85,-1.026,9,9,7,0.0673076923076923,"loop",-0.833333333333333,4.92,7.18700589334483e-05,9.70142977291842,188179.926264625,Inf,0.763784339928386,-8,-2,0,0,-2,0,0,0,0,-2,0,0,-2,0,0,0,0,-14,0,-8,-9,-12,0,-11,-23,-0.421479229989868,-0.151937984496124,0.22299149906395,-0.446035805626598,-0.324607329842932,0.810526315789474,-0.845140032948929,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.124,-0.993,"9:9","150/150","A:G",12.1451538387264,0.919026337424232,119.468044436229,0.101660271548258,5.01153666063045e-06,NA,0.986835744238421,0.170978870202674,0.767057556984365,0.124324963210678,Inf,0.382146811758261,"lineage1","other_mutations_pyrazinamide","VAL",0,"ERR1023294","ERR1023294","lineage1.2.1","","","pnca_p.gly97val","A","-","GLY","GA97","pnca_complex.pdb"
|
|
"G97V","L4","PZA","G","G97",97,"V",1,"Pre-XDR","OM","hydrophobic","hydrophobic","neutral","non-polar","non-polar","non-polar",8.236,-1.664,-0.588,6.12241,-2.616,-1.24,77,85,-1.026,9,9,7,0.0673076923076923,"loop",-0.833333333333333,4.92,7.18700589334483e-05,9.70142977291842,188179.926264625,Inf,0.763784339928386,-8,-2,0,0,-2,0,0,0,0,-2,0,0,-2,0,0,0,0,-14,0,-8,-9,-12,0,-11,-23,-0.421479229989868,-0.151937984496124,0.22299149906395,-0.446035805626598,-0.324607329842932,0.810526315789474,-0.845140032948929,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.124,-0.993,"9:9","150/150","A:G",12.1451538387264,0.919026337424232,119.468044436229,0.101660271548258,5.01153666063045e-06,NA,0.986835744238421,0.170978870202674,0.767057556984365,0.124324963210678,Inf,0.382146811758261,"lineage4","other_mutations_pyrazinamide","VAL",0,"ERR2516757","ERR2516757","lineage4.2.2","gb","UK","pnca_p.gly97val","A","-","GLY","GA97","pnca_complex.pdb"
|
|
"T100A","L3","PZA","T","T100",100,"A",0,"Pre-XDR","OM","hydrophobic","hydrophobic","neutral","non-polar","polar","non-polar",8.272,-1.759,-0.543,0.408316,0.129,-0.1,-36,66,1.347,1,1,81,0.470930232558139,"loop",-0.8,4.18,0.0002874802357337,4.85191417753471,4.85191414039982,4.85118443551178,1.17497090855698,0,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,0,0,0,0,2,0,2,5,-0.445542046605876,-0.14031007751938,0.0148717575157162,0.108952702702703,-0.0261780104712041,-0.387096774193548,0.431730769230769,"Destabilising","Destabilising","Destabilising","Stabilising","Destabilising","neutral",0.842,1.712,"2:1","150/150","K:Y:D:P:A:G:S:R:I:V:L:N:Q:F:E:T",1.57937329521209,0.114342297004304,1.0002536454007,1.57897279602454,0.581889091312076,40.456291107557,0.685913110299906,0.137954936368295,0.860262754777729,0.351471331417763,67.0421060419706,0.278382201819561,"lineage3","other_mutations_pyrazinamide","ALA",0,"ERR2510467","ERR2510467","lineage3","pk","Pakistan","pnca_p.thr100ala","A","S","THR","TA100","pnca_complex.pdb"
|
|
"T100A","L3","PZA","T","T100",100,"A",0,"Pre-XDR","OM","hydrophobic","hydrophobic","neutral","non-polar","polar","non-polar",8.272,-1.759,-0.543,0.408316,0.129,-0.1,-36,66,1.347,1,1,81,0.470930232558139,"loop",-0.8,4.18,0.0002874802357337,4.85191417753471,4.85191414039982,4.85118443551178,1.17497090855698,0,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,0,0,0,0,2,0,2,5,-0.445542046605876,-0.14031007751938,0.0148717575157162,0.108952702702703,-0.0261780104712041,-0.387096774193548,0.431730769230769,"Destabilising","Destabilising","Destabilising","Stabilising","Destabilising","neutral",0.842,1.712,"2:1","150/150","K:Y:D:P:A:G:S:R:I:V:L:N:Q:F:E:T",1.57937329521209,0.114342297004304,1.0002536454007,1.57897279602454,0.581889091312076,40.456291107557,0.685913110299906,0.137954936368295,0.860262754777729,0.351471331417763,67.0421060419706,0.278382201819561,"lineage3","other_mutations_pyrazinamide","ALA",0,"ERR2510395","ERR2510395","lineage3","pk","Pakistan","pnca_p.thr100ala","A","S","THR","TA100","pnca_complex.pdb"
|
|
"T100A","L2","PZA","T","T100",100,"A",1,"Pre-XDR","OM","hydrophobic","hydrophobic","neutral","non-polar","polar","non-polar",8.272,-1.759,-0.543,0.408316,0.129,-0.1,-36,66,1.347,1,1,81,0.470930232558139,"loop",-0.8,4.18,0.0002874802357337,4.85191417753471,4.85191414039982,4.85118443551178,1.17497090855698,0,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,0,0,0,0,2,0,2,5,-0.445542046605876,-0.14031007751938,0.0148717575157162,0.108952702702703,-0.0261780104712041,-0.387096774193548,0.431730769230769,"Destabilising","Destabilising","Destabilising","Stabilising","Destabilising","neutral",0.842,1.712,"2:1","150/150","K:Y:D:P:A:G:S:R:I:V:L:N:Q:F:E:T",1.57937329521209,0.114342297004304,1.0002536454007,1.57897279602454,0.581889091312076,40.456291107557,0.685913110299906,0.137954936368295,0.860262754777729,0.351471331417763,67.0421060419706,0.278382201819561,"lineage2","other_mutations_pyrazinamide","ALA",0,"2501V-sc-2012-10-11T13:40:11Z-1494312,ERR229993","ERR229993","lineage2.2.1","ru","Russia,Samara","pnca_p.thr100ala","A","S","THR","TA100","pnca_complex.pdb"
|
|
"T100A","L4","PZA","T","T100",100,"A",1,"Pre-XDR","OM","hydrophobic","hydrophobic","neutral","non-polar","polar","non-polar",8.272,-1.759,-0.543,0.408316,0.129,-0.1,-36,66,1.347,1,1,81,0.470930232558139,"loop",-0.8,4.18,0.0002874802357337,4.85191417753471,4.85191414039982,4.85118443551178,1.17497090855698,0,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,0,0,0,0,2,0,2,5,-0.445542046605876,-0.14031007751938,0.0148717575157162,0.108952702702703,-0.0261780104712041,-0.387096774193548,0.431730769230769,"Destabilising","Destabilising","Destabilising","Stabilising","Destabilising","neutral",0.842,1.712,"2:1","150/150","K:Y:D:P:A:G:S:R:I:V:L:N:Q:F:E:T",1.57937329521209,0.114342297004304,1.0002536454007,1.57897279602454,0.581889091312076,40.456291107557,0.685913110299906,0.137954936368295,0.860262754777729,0.351471331417763,67.0421060419706,0.278382201819561,"lineage4","other_mutations_pyrazinamide","ALA",0,"ERR2510610","ERR2510610","lineage4.1.1.3","pk","Pakistan","pnca_p.thr100ala","A","S","THR","TA100","pnca_complex.pdb"
|
|
"T100A","L3","PZA","T","T100",100,"A",NA,"Pre-XDR","OM","hydrophobic","hydrophobic","neutral","non-polar","polar","non-polar",8.272,-1.759,-0.543,0.408316,0.129,-0.1,-36,66,1.347,1,1,81,0.470930232558139,"loop",-0.8,4.18,0.0002874802357337,4.85191417753471,4.85191414039982,4.85118443551178,1.17497090855698,0,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,0,0,0,0,2,0,2,5,-0.445542046605876,-0.14031007751938,0.0148717575157162,0.108952702702703,-0.0261780104712041,-0.387096774193548,0.431730769230769,"Destabilising","Destabilising","Destabilising","Stabilising","Destabilising","neutral",0.842,1.712,"2:1","150/150","K:Y:D:P:A:G:S:R:I:V:L:N:Q:F:E:T",1.57937329521209,0.114342297004304,1.0002536454007,1.57897279602454,0.581889091312076,40.456291107557,0.685913110299906,0.137954936368295,0.860262754777729,0.351471331417763,67.0421060419706,0.278382201819561,"lineage3","other_mutations_pyrazinamide","ALA",0,"ERR2510383","ERR2510383","lineage3","pk","Pakistan","pnca_p.thr100ala","A","S","THR","TA100","pnca_complex.pdb"
|
|
"T100I","L2","PZA","T","T100",100,"I",1,"XDR","DM","hydrophobic","hydrophobic","neutral","non-polar","polar","non-polar",8.272,-1.537,0.379,0.808015,-0.042,-0.36,14,59,1.347,1,1,81,0.470930232558139,"loop",-0.8,4.18,0.000646830530401,38.9169126950654,38.9169126367816,38.9145296299157,27.8738145664613,-6,2,0,0,2,0,0,0,0,2,0,2,0,0,0,0,0,-1,0,-3,0,0,0,0,-2,-0.389311043566363,0.322278911564626,0.0294296651345071,-0.00716112531969309,-0.094240837696335,0.147368421052632,0.431730769230769,"Destabilising","Stabilising","Destabilising","Destabilising","Destabilising","effect",0.842,1.712,"2:1","150/150","K:Y:D:P:A:G:S:R:I:V:L:N:Q:F:E:T",3.66142892829214,0.0005578275078108,1.06087424525349,3.45133171502081,7.13685172054609,722.165073757354,1.59013838008863,5.5228318480997e-06,5.25783817940065,5.21074959149254,1710.75565736304,1.29490403629991e-07,"lineage2","dr_mutations_pyrazinamide","ILE",0,"ERR1873474","ERR1873474","lineage2.2.1","za","South Africa","pnca_p.thr100ile","A","S","THR","TA100","pnca_complex.pdb"
|
|
"T100I","L2","PZA","T","T100",100,"I",1,"XDR","DM","hydrophobic","hydrophobic","neutral","non-polar","polar","non-polar",8.272,-1.537,0.379,0.808015,-0.042,-0.36,14,59,1.347,1,1,81,0.470930232558139,"loop",-0.8,4.18,0.000646830530401,38.9169126950654,38.9169126367816,38.9145296299157,27.8738145664613,-6,2,0,0,2,0,0,0,0,2,0,2,0,0,0,0,0,-1,0,-3,0,0,0,0,-2,-0.389311043566363,0.322278911564626,0.0294296651345071,-0.00716112531969309,-0.094240837696335,0.147368421052632,0.431730769230769,"Destabilising","Stabilising","Destabilising","Destabilising","Destabilising","effect",0.842,1.712,"2:1","150/150","K:Y:D:P:A:G:S:R:I:V:L:N:Q:F:E:T",3.66142892829214,0.0005578275078108,1.06087424525349,3.45133171502081,7.13685172054609,722.165073757354,1.59013838008863,5.5228318480997e-06,5.25783817940065,5.21074959149254,1710.75565736304,1.29490403629991e-07,"lineage2","dr_mutations_pyrazinamide","ILE",0,"ERR1873562","ERR1873562","lineage2.2.1","za","South Africa","pnca_p.thr100ile","A","S","THR","TA100","pnca_complex.pdb"
|
|
"T100I","L4","PZA","T","T100",100,"I",0,"MDR","DM","hydrophobic","hydrophobic","neutral","non-polar","polar","non-polar",8.272,-1.537,0.379,0.808015,-0.042,-0.36,14,59,1.347,1,1,81,0.470930232558139,"loop",-0.8,4.18,0.000646830530401,38.9169126950654,38.9169126367816,38.9145296299157,27.8738145664613,-6,2,0,0,2,0,0,0,0,2,0,2,0,0,0,0,0,-1,0,-3,0,0,0,0,-2,-0.389311043566363,0.322278911564626,0.0294296651345071,-0.00716112531969309,-0.094240837696335,0.147368421052632,0.431730769230769,"Destabilising","Stabilising","Destabilising","Destabilising","Destabilising","effect",0.842,1.712,"2:1","150/150","K:Y:D:P:A:G:S:R:I:V:L:N:Q:F:E:T",3.66142892829214,0.0005578275078108,1.06087424525349,3.45133171502081,7.13685172054609,722.165073757354,1.59013838008863,5.5228318480997e-06,5.25783817940065,5.21074959149254,1710.75565736304,1.29490403629991e-07,"lineage4","dr_mutations_pyrazinamide","ILE",0,"ERR2510373","ERR2510373","lineage4.2.2","pk","Pakistan","pnca_p.thr100ile","A","S","THR","TA100","pnca_complex.pdb"
|
|
"T100I","L2","PZA","T","T100",100,"I",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","neutral","non-polar","polar","non-polar",8.272,-1.537,0.379,0.808015,-0.042,-0.36,14,59,1.347,1,1,81,0.470930232558139,"loop",-0.8,4.18,0.000646830530401,38.9169126950654,38.9169126367816,38.9145296299157,27.8738145664613,-6,2,0,0,2,0,0,0,0,2,0,2,0,0,0,0,0,-1,0,-3,0,0,0,0,-2,-0.389311043566363,0.322278911564626,0.0294296651345071,-0.00716112531969309,-0.094240837696335,0.147368421052632,0.431730769230769,"Destabilising","Stabilising","Destabilising","Destabilising","Destabilising","effect",0.842,1.712,"2:1","150/150","K:Y:D:P:A:G:S:R:I:V:L:N:Q:F:E:T",3.66142892829214,0.0005578275078108,1.06087424525349,3.45133171502081,7.13685172054609,722.165073757354,1.59013838008863,5.5228318480997e-06,5.25783817940065,5.21074959149254,1710.75565736304,1.29490403629991e-07,"lineage2","dr_mutations_pyrazinamide","ILE",0,"ERR1023465","ERR1023465","lineage2.2.1","","","pnca_p.thr100ile","A","S","THR","TA100","pnca_complex.pdb"
|
|
"T100I","L2","PZA","T","T100",100,"I",1,"Pre-XDR","DM","hydrophobic","hydrophobic","neutral","non-polar","polar","non-polar",8.272,-1.537,0.379,0.808015,-0.042,-0.36,14,59,1.347,1,1,81,0.470930232558139,"loop",-0.8,4.18,0.000646830530401,38.9169126950654,38.9169126367816,38.9145296299157,27.8738145664613,-6,2,0,0,2,0,0,0,0,2,0,2,0,0,0,0,0,-1,0,-3,0,0,0,0,-2,-0.389311043566363,0.322278911564626,0.0294296651345071,-0.00716112531969309,-0.094240837696335,0.147368421052632,0.431730769230769,"Destabilising","Stabilising","Destabilising","Destabilising","Destabilising","effect",0.842,1.712,"2:1","150/150","K:Y:D:P:A:G:S:R:I:V:L:N:Q:F:E:T",3.66142892829214,0.0005578275078108,1.06087424525349,3.45133171502081,7.13685172054609,722.165073757354,1.59013838008863,5.5228318480997e-06,5.25783817940065,5.21074959149254,1710.75565736304,1.29490403629991e-07,"lineage2","dr_mutations_pyrazinamide","ILE",0,"ERR1873560","ERR1873560","lineage2.2.1","za","South Africa","pnca_p.thr100ile","A","S","THR","TA100","pnca_complex.pdb"
|
|
"T100I","L2","PZA","T","T100",100,"I",1,"XDR","DM","hydrophobic","hydrophobic","neutral","non-polar","polar","non-polar",8.272,-1.537,0.379,0.808015,-0.042,-0.36,14,59,1.347,1,1,81,0.470930232558139,"loop",-0.8,4.18,0.000646830530401,38.9169126950654,38.9169126367816,38.9145296299157,27.8738145664613,-6,2,0,0,2,0,0,0,0,2,0,2,0,0,0,0,0,-1,0,-3,0,0,0,0,-2,-0.389311043566363,0.322278911564626,0.0294296651345071,-0.00716112531969309,-0.094240837696335,0.147368421052632,0.431730769230769,"Destabilising","Stabilising","Destabilising","Destabilising","Destabilising","effect",0.842,1.712,"2:1","150/150","K:Y:D:P:A:G:S:R:I:V:L:N:Q:F:E:T",3.66142892829214,0.0005578275078108,1.06087424525349,3.45133171502081,7.13685172054609,722.165073757354,1.59013838008863,5.5228318480997e-06,5.25783817940065,5.21074959149254,1710.75565736304,1.29490403629991e-07,"lineage2","dr_mutations_pyrazinamide","ILE",0,"ERR1873556","ERR1873556","lineage2.2.1","za","South Africa","pnca_p.thr100ile","A","S","THR","TA100","pnca_complex.pdb"
|
|
"T100I","L2","PZA","T","T100",100,"I",1,"XDR","DM","hydrophobic","hydrophobic","neutral","non-polar","polar","non-polar",8.272,-1.537,0.379,0.808015,-0.042,-0.36,14,59,1.347,1,1,81,0.470930232558139,"loop",-0.8,4.18,0.000646830530401,38.9169126950654,38.9169126367816,38.9145296299157,27.8738145664613,-6,2,0,0,2,0,0,0,0,2,0,2,0,0,0,0,0,-1,0,-3,0,0,0,0,-2,-0.389311043566363,0.322278911564626,0.0294296651345071,-0.00716112531969309,-0.094240837696335,0.147368421052632,0.431730769230769,"Destabilising","Stabilising","Destabilising","Destabilising","Destabilising","effect",0.842,1.712,"2:1","150/150","K:Y:D:P:A:G:S:R:I:V:L:N:Q:F:E:T",3.66142892829214,0.0005578275078108,1.06087424525349,3.45133171502081,7.13685172054609,722.165073757354,1.59013838008863,5.5228318480997e-06,5.25783817940065,5.21074959149254,1710.75565736304,1.29490403629991e-07,"lineage2","dr_mutations_pyrazinamide","ILE",0,"ERR1873509","ERR1873509","lineage2.2.1","za","South Africa","pnca_p.thr100ile","A","S","THR","TA100","pnca_complex.pdb"
|
|
"T100I","L2","PZA","T","T100",100,"I",1,"XDR","DM","hydrophobic","hydrophobic","neutral","non-polar","polar","non-polar",8.272,-1.537,0.379,0.808015,-0.042,-0.36,14,59,1.347,1,1,81,0.470930232558139,"loop",-0.8,4.18,0.000646830530401,38.9169126950654,38.9169126367816,38.9145296299157,27.8738145664613,-6,2,0,0,2,0,0,0,0,2,0,2,0,0,0,0,0,-1,0,-3,0,0,0,0,-2,-0.389311043566363,0.322278911564626,0.0294296651345071,-0.00716112531969309,-0.094240837696335,0.147368421052632,0.431730769230769,"Destabilising","Stabilising","Destabilising","Destabilising","Destabilising","effect",0.842,1.712,"2:1","150/150","K:Y:D:P:A:G:S:R:I:V:L:N:Q:F:E:T",3.66142892829214,0.0005578275078108,1.06087424525349,3.45133171502081,7.13685172054609,722.165073757354,1.59013838008863,5.5228318480997e-06,5.25783817940065,5.21074959149254,1710.75565736304,1.29490403629991e-07,"lineage2","dr_mutations_pyrazinamide","ILE",0,"ERR1873447","ERR1873447","lineage2.2.1","za","South Africa","pnca_p.thr100ile","A","S","THR","TA100","pnca_complex.pdb"
|
|
"T100I","L2","PZA","T","T100",100,"I",1,"Pre-XDR","DM","hydrophobic","hydrophobic","neutral","non-polar","polar","non-polar",8.272,-1.537,0.379,0.808015,-0.042,-0.36,14,59,1.347,1,1,81,0.470930232558139,"loop",-0.8,4.18,0.000646830530401,38.9169126950654,38.9169126367816,38.9145296299157,27.8738145664613,-6,2,0,0,2,0,0,0,0,2,0,2,0,0,0,0,0,-1,0,-3,0,0,0,0,-2,-0.389311043566363,0.322278911564626,0.0294296651345071,-0.00716112531969309,-0.094240837696335,0.147368421052632,0.431730769230769,"Destabilising","Stabilising","Destabilising","Destabilising","Destabilising","effect",0.842,1.712,"2:1","150/150","K:Y:D:P:A:G:S:R:I:V:L:N:Q:F:E:T",3.66142892829214,0.0005578275078108,1.06087424525349,3.45133171502081,7.13685172054609,722.165073757354,1.59013838008863,5.5228318480997e-06,5.25783817940065,5.21074959149254,1710.75565736304,1.29490403629991e-07,"lineage2","dr_mutations_pyrazinamide","ILE",0,"ERR2515371","ERR2515371","lineage2.2.1","za","South Africa","pnca_p.thr100ile","A","S","THR","TA100","pnca_complex.pdb"
|
|
"T100I","L2","PZA","T","T100",100,"I",1,"XDR","DM","hydrophobic","hydrophobic","neutral","non-polar","polar","non-polar",8.272,-1.537,0.379,0.808015,-0.042,-0.36,14,59,1.347,1,1,81,0.470930232558139,"loop",-0.8,4.18,0.000646830530401,38.9169126950654,38.9169126367816,38.9145296299157,27.8738145664613,-6,2,0,0,2,0,0,0,0,2,0,2,0,0,0,0,0,-1,0,-3,0,0,0,0,-2,-0.389311043566363,0.322278911564626,0.0294296651345071,-0.00716112531969309,-0.094240837696335,0.147368421052632,0.431730769230769,"Destabilising","Stabilising","Destabilising","Destabilising","Destabilising","effect",0.842,1.712,"2:1","150/150","K:Y:D:P:A:G:S:R:I:V:L:N:Q:F:E:T",3.66142892829214,0.0005578275078108,1.06087424525349,3.45133171502081,7.13685172054609,722.165073757354,1.59013838008863,5.5228318480997e-06,5.25783817940065,5.21074959149254,1710.75565736304,1.29490403629991e-07,"lineage2","dr_mutations_pyrazinamide","ILE",0,"ERR1873470","ERR1873470","lineage2.2.1","za","South Africa","pnca_p.thr100ile","A","S","THR","TA100","pnca_complex.pdb"
|
|
"T100I","L2;L4","PZA","T","T100",100,"I",NA,"MDR","DM","hydrophobic","hydrophobic","neutral","non-polar","polar","non-polar",8.272,-1.537,0.379,0.808015,-0.042,-0.36,14,59,1.347,1,1,81,0.470930232558139,"loop",-0.8,4.18,0.000646830530401,38.9169126950654,38.9169126367816,38.9145296299157,27.8738145664613,-6,2,0,0,2,0,0,0,0,2,0,2,0,0,0,0,0,-1,0,-3,0,0,0,0,-2,-0.389311043566363,0.322278911564626,0.0294296651345071,-0.00716112531969309,-0.094240837696335,0.147368421052632,0.431730769230769,"Destabilising","Stabilising","Destabilising","Destabilising","Destabilising","effect",0.842,1.712,"2:1","150/150","K:Y:D:P:A:G:S:R:I:V:L:N:Q:F:E:T",3.66142892829214,0.0005578275078108,1.06087424525349,3.45133171502081,7.13685172054609,722.165073757354,1.59013838008863,5.5228318480997e-06,5.25783817940065,5.21074959149254,1710.75565736304,1.29490403629991e-07,"lineage2;lineage4","dr_mutations_pyrazinamide","ILE",0,"ERS3466682","ERR3340710","lineage4.1.1.3;lineage2.2.1","za","","pnca_p.thr100ile","A","S","THR","TA100","pnca_complex.pdb"
|
|
"T100P","L2","PZA","T","T100",100,"P",NA,"MDR","OM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",8.272,-1.685,-0.488,1.65141,-0.412,0.03,18,59,1.347,1,1,81,0.470930232558139,"loop",-0.8,4.18,0.0005030904125341,68.0817875210792,1394038.39846607,Inf,28.35828361563,0,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,0,2,0,-2,0,0,-2,-4,-0.426798378926039,-0.12609819121447,0.0601479468818974,-0.0702472293265132,0.0168539325842696,0.189473684210526,0.431730769230769,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",0.842,1.712,"2:1","150/150","K:Y:D:P:A:G:S:R:I:V:L:N:Q:F:E:T",14.1477154154513,0.908235680148,122.741582019402,0.115264242017142,22.9578143501725,NA,1.83303094984313,4.24048522418865e-06,5.37258444573496,7.00237574052121,Inf,1.00814491180914e-07,"lineage2","other_mutations_pyrazinamide","PRO",0,"SAMN02403469","SRR1181050_SRR1180926","lineage2.2.1","za","South Africa","pnca_p.thr100pro","A","S","THR","TA100","pnca_complex.pdb"
|
|
"T100P","L4","PZA","T","T100",100,"P",1,"MDR","OM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",8.272,-1.685,-0.488,1.65141,-0.412,0.03,18,59,1.347,1,1,81,0.470930232558139,"loop",-0.8,4.18,0.0005030904125341,68.0817875210792,1394038.39846607,Inf,28.35828361563,0,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,0,2,0,-2,0,0,-2,-4,-0.426798378926039,-0.12609819121447,0.0601479468818974,-0.0702472293265132,0.0168539325842696,0.189473684210526,0.431730769230769,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",0.842,1.712,"2:1","150/150","K:Y:D:P:A:G:S:R:I:V:L:N:Q:F:E:T",14.1477154154513,0.908235680148,122.741582019402,0.115264242017142,22.9578143501725,NA,1.83303094984313,4.24048522418865e-06,5.37258444573496,7.00237574052121,Inf,1.00814491180914e-07,"lineage4","other_mutations_pyrazinamide","PRO",0,"ERR2516486","ERR2516486","lineage4.1.2.1","pe","Peru","pnca_p.thr100pro","A","S","THR","TA100","pnca_complex.pdb"
|
|
"T100P","L2","PZA","T","T100",100,"P",1,"XDR","OM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",8.272,-1.685,-0.488,1.65141,-0.412,0.03,18,59,1.347,1,1,81,0.470930232558139,"loop",-0.8,4.18,0.0005030904125341,68.0817875210792,1394038.39846607,Inf,28.35828361563,0,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,0,2,0,-2,0,0,-2,-4,-0.426798378926039,-0.12609819121447,0.0601479468818974,-0.0702472293265132,0.0168539325842696,0.189473684210526,0.431730769230769,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",0.842,1.712,"2:1","150/150","K:Y:D:P:A:G:S:R:I:V:L:N:Q:F:E:T",14.1477154154513,0.908235680148,122.741582019402,0.115264242017142,22.9578143501725,NA,1.83303094984313,4.24048522418865e-06,5.37258444573496,7.00237574052121,Inf,1.00814491180914e-07,"lineage2","other_mutations_pyrazinamide","PRO",0,"MDR_27126","SRR6824546","lineage2.2.1","cn","China: Weiyang District, Xi'an City, Shaanxi Province","pnca_p.thr100pro","A","S","THR","TA100","pnca_complex.pdb"
|
|
"T100P","L2","PZA","T","T100",100,"P",1,"XDR","OM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",8.272,-1.685,-0.488,1.65141,-0.412,0.03,18,59,1.347,1,1,81,0.470930232558139,"loop",-0.8,4.18,0.0005030904125341,68.0817875210792,1394038.39846607,Inf,28.35828361563,0,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,0,2,0,-2,0,0,-2,-4,-0.426798378926039,-0.12609819121447,0.0601479468818974,-0.0702472293265132,0.0168539325842696,0.189473684210526,0.431730769230769,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",0.842,1.712,"2:1","150/150","K:Y:D:P:A:G:S:R:I:V:L:N:Q:F:E:T",14.1477154154513,0.908235680148,122.741582019402,0.115264242017142,22.9578143501725,NA,1.83303094984313,4.24048522418865e-06,5.37258444573496,7.00237574052121,Inf,1.00814491180914e-07,"lineage2","other_mutations_pyrazinamide","PRO",0,"ERS457650","ERR551862_ERR551861","lineage2.2.1","uz","Nukus","pnca_p.thr100pro","A","S","THR","TA100","pnca_complex.pdb"
|
|
"T100P","L2","PZA","T","T100",100,"P",NA,"XDR","OM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",8.272,-1.685,-0.488,1.65141,-0.412,0.03,18,59,1.347,1,1,81,0.470930232558139,"loop",-0.8,4.18,0.0005030904125341,68.0817875210792,1394038.39846607,Inf,28.35828361563,0,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,0,2,0,-2,0,0,-2,-4,-0.426798378926039,-0.12609819121447,0.0601479468818974,-0.0702472293265132,0.0168539325842696,0.189473684210526,0.431730769230769,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",0.842,1.712,"2:1","150/150","K:Y:D:P:A:G:S:R:I:V:L:N:Q:F:E:T",14.1477154154513,0.908235680148,122.741582019402,0.115264242017142,22.9578143501725,NA,1.83303094984313,4.24048522418865e-06,5.37258444573496,7.00237574052121,Inf,1.00814491180914e-07,"lineage2","other_mutations_pyrazinamide","PRO",0,"SAMN02403468","SRR1173266_SRR1173211_SRR1167297_SRR1165220","lineage2.2.1","za","South Africa","pnca_p.thr100pro","A","S","THR","TA100","pnca_complex.pdb"
|
|
"T100P","L2","PZA","T","T100",100,"P",NA,"XDR","OM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",8.272,-1.685,-0.488,1.65141,-0.412,0.03,18,59,1.347,1,1,81,0.470930232558139,"loop",-0.8,4.18,0.0005030904125341,68.0817875210792,1394038.39846607,Inf,28.35828361563,0,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,0,2,0,-2,0,0,-2,-4,-0.426798378926039,-0.12609819121447,0.0601479468818974,-0.0702472293265132,0.0168539325842696,0.189473684210526,0.431730769230769,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",0.842,1.712,"2:1","150/150","K:Y:D:P:A:G:S:R:I:V:L:N:Q:F:E:T",14.1477154154513,0.908235680148,122.741582019402,0.115264242017142,22.9578143501725,NA,1.83303094984313,4.24048522418865e-06,5.37258444573496,7.00237574052121,Inf,1.00814491180914e-07,"lineage2","other_mutations_pyrazinamide","PRO",0,"SAMN02360610","SRR1013662_SRR1013663_SRR1049058_SRR1049059","lineage2.2.2","kr","South Korea","pnca_p.thr100pro","A","S","THR","TA100","pnca_complex.pdb"
|
|
"T100P","L2","PZA","T","T100",100,"P",1,"Pre-MDR","OM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",8.272,-1.685,-0.488,1.65141,-0.412,0.03,18,59,1.347,1,1,81,0.470930232558139,"loop",-0.8,4.18,0.0005030904125341,68.0817875210792,1394038.39846607,Inf,28.35828361563,0,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,0,2,0,-2,0,0,-2,-4,-0.426798378926039,-0.12609819121447,0.0601479468818974,-0.0702472293265132,0.0168539325842696,0.189473684210526,0.431730769230769,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",0.842,1.712,"2:1","150/150","K:Y:D:P:A:G:S:R:I:V:L:N:Q:F:E:T",14.1477154154513,0.908235680148,122.741582019402,0.115264242017142,22.9578143501725,NA,1.83303094984313,4.24048522418865e-06,5.37258444573496,7.00237574052121,Inf,1.00814491180914e-07,"lineage2","other_mutations_pyrazinamide","PRO",0,"ERR108423,1060D-sc-2011-10-12T14:58:11Z-1289088","ERR108423","lineage2.2.1","ru","Russia","pnca_p.thr100pro","A","S","THR","TA100","pnca_complex.pdb"
|
|
"T100P","L2","PZA","T","T100",100,"P",NA,"MDR","OM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",8.272,-1.685,-0.488,1.65141,-0.412,0.03,18,59,1.347,1,1,81,0.470930232558139,"loop",-0.8,4.18,0.0005030904125341,68.0817875210792,1394038.39846607,Inf,28.35828361563,0,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,0,2,0,-2,0,0,-2,-4,-0.426798378926039,-0.12609819121447,0.0601479468818974,-0.0702472293265132,0.0168539325842696,0.189473684210526,0.431730769230769,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",0.842,1.712,"2:1","150/150","K:Y:D:P:A:G:S:R:I:V:L:N:Q:F:E:T",14.1477154154513,0.908235680148,122.741582019402,0.115264242017142,22.9578143501725,NA,1.83303094984313,4.24048522418865e-06,5.37258444573496,7.00237574052121,Inf,1.00814491180914e-07,"lineage2","other_mutations_pyrazinamide","PRO",0,"SRR5709770,SAMN07236374","SRR5709770","lineage2.2.1.1","th","Thailand","pnca_p.thr100pro","A","S","THR","TA100","pnca_complex.pdb"
|
|
"T100P","L2","PZA","T","T100",100,"P",1,"MDR","OM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",8.272,-1.685,-0.488,1.65141,-0.412,0.03,18,59,1.347,1,1,81,0.470930232558139,"loop",-0.8,4.18,0.0005030904125341,68.0817875210792,1394038.39846607,Inf,28.35828361563,0,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,0,2,0,-2,0,0,-2,-4,-0.426798378926039,-0.12609819121447,0.0601479468818974,-0.0702472293265132,0.0168539325842696,0.189473684210526,0.431730769230769,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",0.842,1.712,"2:1","150/150","K:Y:D:P:A:G:S:R:I:V:L:N:Q:F:E:T",14.1477154154513,0.908235680148,122.741582019402,0.115264242017142,22.9578143501725,NA,1.83303094984313,4.24048522418865e-06,5.37258444573496,7.00237574052121,Inf,1.00814491180914e-07,"lineage2","other_mutations_pyrazinamide","PRO",0,"MDR_13157","SRR6824628","lineage2.2.1","cn","China: Changting County, Longyan City, Fujian Province","pnca_p.thr100pro","A","S","THR","TA100","pnca_complex.pdb"
|
|
"T100P","L2","PZA","T","T100",100,"P",1,"Pre-XDR","OM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",8.272,-1.685,-0.488,1.65141,-0.412,0.03,18,59,1.347,1,1,81,0.470930232558139,"loop",-0.8,4.18,0.0005030904125341,68.0817875210792,1394038.39846607,Inf,28.35828361563,0,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,0,2,0,-2,0,0,-2,-4,-0.426798378926039,-0.12609819121447,0.0601479468818974,-0.0702472293265132,0.0168539325842696,0.189473684210526,0.431730769230769,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",0.842,1.712,"2:1","150/150","K:Y:D:P:A:G:S:R:I:V:L:N:Q:F:E:T",14.1477154154513,0.908235680148,122.741582019402,0.115264242017142,22.9578143501725,NA,1.83303094984313,4.24048522418865e-06,5.37258444573496,7.00237574052121,Inf,1.00814491180914e-07,"lineage2","other_mutations_pyrazinamide","PRO",0,"ERR228050,2275Z-sc-2012-10-11T13:38:36Z-1494214","ERR228050","lineage2.2.1","ru","Russia,Samara","pnca_p.thr100pro","A","S","THR","TA100","pnca_complex.pdb"
|
|
"T100P","L2","PZA","T","T100",100,"P",NA,"XDR","OM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",8.272,-1.685,-0.488,1.65141,-0.412,0.03,18,59,1.347,1,1,81,0.470930232558139,"loop",-0.8,4.18,0.0005030904125341,68.0817875210792,1394038.39846607,Inf,28.35828361563,0,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,0,2,0,-2,0,0,-2,-4,-0.426798378926039,-0.12609819121447,0.0601479468818974,-0.0702472293265132,0.0168539325842696,0.189473684210526,0.431730769230769,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",0.842,1.712,"2:1","150/150","K:Y:D:P:A:G:S:R:I:V:L:N:Q:F:E:T",14.1477154154513,0.908235680148,122.741582019402,0.115264242017142,22.9578143501725,NA,1.83303094984313,4.24048522418865e-06,5.37258444573496,7.00237574052121,Inf,1.00814491180914e-07,"lineage2","other_mutations_pyrazinamide","PRO",0,"SAMN07360948,SRR5837710","SRR5837710","lineage2.2.1.1","th","Thailand","pnca_p.thr100pro","A","S","THR","TA100","pnca_complex.pdb"
|
|
"T100P","L2","PZA","T","T100",100,"P",1,"MDR","OM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",8.272,-1.685,-0.488,1.65141,-0.412,0.03,18,59,1.347,1,1,81,0.470930232558139,"loop",-0.8,4.18,0.0005030904125341,68.0817875210792,1394038.39846607,Inf,28.35828361563,0,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,0,2,0,-2,0,0,-2,-4,-0.426798378926039,-0.12609819121447,0.0601479468818974,-0.0702472293265132,0.0168539325842696,0.189473684210526,0.431730769230769,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",0.842,1.712,"2:1","150/150","K:Y:D:P:A:G:S:R:I:V:L:N:Q:F:E:T",14.1477154154513,0.908235680148,122.741582019402,0.115264242017142,22.9578143501725,NA,1.83303094984313,4.24048522418865e-06,5.37258444573496,7.00237574052121,Inf,1.00814491180914e-07,"lineage2","other_mutations_pyrazinamide","PRO",0,"ERR2516965","ERR2516965","lineage2.2.1.1","gb","UK","pnca_p.thr100pro","A","S","THR","TA100","pnca_complex.pdb"
|
|
"T100P","L2","PZA","T","T100",100,"P",NA,"XDR","OM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",8.272,-1.685,-0.488,1.65141,-0.412,0.03,18,59,1.347,1,1,81,0.470930232558139,"loop",-0.8,4.18,0.0005030904125341,68.0817875210792,1394038.39846607,Inf,28.35828361563,0,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,0,2,0,-2,0,0,-2,-4,-0.426798378926039,-0.12609819121447,0.0601479468818974,-0.0702472293265132,0.0168539325842696,0.189473684210526,0.431730769230769,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",0.842,1.712,"2:1","150/150","K:Y:D:P:A:G:S:R:I:V:L:N:Q:F:E:T",14.1477154154513,0.908235680148,122.741582019402,0.115264242017142,22.9578143501725,NA,1.83303094984313,4.24048522418865e-06,5.37258444573496,7.00237574052121,Inf,1.00814491180914e-07,"lineage2","other_mutations_pyrazinamide","PRO",0,"SRS797128","SRR1723638","lineage2.2.1","cn","China:Shaanxi","pnca_p.thr100pro","A","S","THR","TA100","pnca_complex.pdb"
|
|
"T100P","L2","PZA","T","T100",100,"P",NA,"MDR","OM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",8.272,-1.685,-0.488,1.65141,-0.412,0.03,18,59,1.347,1,1,81,0.470930232558139,"loop",-0.8,4.18,0.0005030904125341,68.0817875210792,1394038.39846607,Inf,28.35828361563,0,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,0,2,0,-2,0,0,-2,-4,-0.426798378926039,-0.12609819121447,0.0601479468818974,-0.0702472293265132,0.0168539325842696,0.189473684210526,0.431730769230769,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",0.842,1.712,"2:1","150/150","K:Y:D:P:A:G:S:R:I:V:L:N:Q:F:E:T",14.1477154154513,0.908235680148,122.741582019402,0.115264242017142,22.9578143501725,NA,1.83303094984313,4.24048522418865e-06,5.37258444573496,7.00237574052121,Inf,1.00814491180914e-07,"lineage2","other_mutations_pyrazinamide","PRO",0,"SRS796983","SRR1723472_SRR1723471","lineage2.2.1","cn","China:Fujian","pnca_p.thr100pro","A","S","THR","TA100","pnca_complex.pdb"
|
|
"T100P","L5","PZA","T","T100",100,"P",NA,"MDR","OM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",8.272,-1.685,-0.488,1.65141,-0.412,0.03,18,59,1.347,1,1,81,0.470930232558139,"loop",-0.8,4.18,0.0005030904125341,68.0817875210792,1394038.39846607,Inf,28.35828361563,0,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,0,2,0,-2,0,0,-2,-4,-0.426798378926039,-0.12609819121447,0.0601479468818974,-0.0702472293265132,0.0168539325842696,0.189473684210526,0.431730769230769,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",0.842,1.712,"2:1","150/150","K:Y:D:P:A:G:S:R:I:V:L:N:Q:F:E:T",14.1477154154513,0.908235680148,122.741582019402,0.115264242017142,22.9578143501725,NA,1.83303094984313,4.24048522418865e-06,5.37258444573496,7.00237574052121,Inf,1.00814491180914e-07,"lineage5","other_mutations_pyrazinamide","PRO",0,"ERR2706910","ERR2706910","lineage5","cd","Democratic Republic of Congo","pnca_p.thr100pro","A","S","THR","TA100","pnca_complex.pdb"
|
|
"T100P","L2","PZA","T","T100",100,"P",NA,"Pre-XDR","OM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",8.272,-1.685,-0.488,1.65141,-0.412,0.03,18,59,1.347,1,1,81,0.470930232558139,"loop",-0.8,4.18,0.0005030904125341,68.0817875210792,1394038.39846607,Inf,28.35828361563,0,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,0,2,0,-2,0,0,-2,-4,-0.426798378926039,-0.12609819121447,0.0601479468818974,-0.0702472293265132,0.0168539325842696,0.189473684210526,0.431730769230769,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",0.842,1.712,"2:1","150/150","K:Y:D:P:A:G:S:R:I:V:L:N:Q:F:E:T",14.1477154154513,0.908235680148,122.741582019402,0.115264242017142,22.9578143501725,NA,1.83303094984313,4.24048522418865e-06,5.37258444573496,7.00237574052121,Inf,1.00814491180914e-07,"lineage2","other_mutations_pyrazinamide","PRO",0,"SRS936036,SAMN03653293","SRR2024994","lineage2.2.1","cn","China","pnca_p.thr100pro","A","S","THR","TA100","pnca_complex.pdb"
|
|
"T100P","L4","PZA","T","T100",100,"P",NA,"Pre-XDR","OM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",8.272,-1.685,-0.488,1.65141,-0.412,0.03,18,59,1.347,1,1,81,0.470930232558139,"loop",-0.8,4.18,0.0005030904125341,68.0817875210792,1394038.39846607,Inf,28.35828361563,0,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,0,2,0,-2,0,0,-2,-4,-0.426798378926039,-0.12609819121447,0.0601479468818974,-0.0702472293265132,0.0168539325842696,0.189473684210526,0.431730769230769,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",0.842,1.712,"2:1","150/150","K:Y:D:P:A:G:S:R:I:V:L:N:Q:F:E:T",14.1477154154513,0.908235680148,122.741582019402,0.115264242017142,22.9578143501725,NA,1.83303094984313,4.24048522418865e-06,5.37258444573496,7.00237574052121,Inf,1.00814491180914e-07,"lineage4","other_mutations_pyrazinamide","PRO",0,"SAMN02360562","SRR1013565_SRR1048865_SRR1013566_SRR1048866","lineage4.4.2","kr","South Korea","pnca_p.thr100pro","A","S","THR","TA100","pnca_complex.pdb"
|
|
"T100P","L2","PZA","T","T100",100,"P",NA,"XDR","OM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",8.272,-1.685,-0.488,1.65141,-0.412,0.03,18,59,1.347,1,1,81,0.470930232558139,"loop",-0.8,4.18,0.0005030904125341,68.0817875210792,1394038.39846607,Inf,28.35828361563,0,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,0,2,0,-2,0,0,-2,-4,-0.426798378926039,-0.12609819121447,0.0601479468818974,-0.0702472293265132,0.0168539325842696,0.189473684210526,0.431730769230769,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",0.842,1.712,"2:1","150/150","K:Y:D:P:A:G:S:R:I:V:L:N:Q:F:E:T",14.1477154154513,0.908235680148,122.741582019402,0.115264242017142,22.9578143501725,NA,1.83303094984313,4.24048522418865e-06,5.37258444573496,7.00237574052121,Inf,1.00814491180914e-07,"lineage2","other_mutations_pyrazinamide","PRO",0,"SAMN02360596","SRR1013631_SRR1049029_SRR1013632_SRR1049028","lineage2.2.2","kr","South Korea","pnca_p.thr100pro","A","S","THR","TA100","pnca_complex.pdb"
|
|
"A102P","L4","PZA","A","A102",102,"P",1,"MDR","OM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",3.5,-0.23,-1.249,-0.616782,-2.115,0.13,83,91,-0.862,8,8,10,0.0775193798449612,"loop",0.0333333333333332,5.51,0.0005749604714675,14.5802781289507,14.5802277940116,14.5801759034061,15.0663448164144,0,0,0,0,0,0,0,0,0,0,0,2,-2,0,0,0,0,-8,0,-2,-6,-6,0,-2,-5,-0.058257345491388,-0.322739018087855,-0.118584557409828,-0.360613810741688,0.0730337078651685,0.873684210526316,-0.71004942339374,"Destabilising","Destabilising","Stabilising","Destabilising","Stabilising","effect",-0.955,-0.827,"9:8","150/150","M:E:S:G:A:H:Q",2.6796663501904,0.0010245352377103,0.816050632122414,3.28370108999368,3.35697961122126,99.5538692592317,1.16376580853041,0.0005075351447614,3.29453387923245,2.60435121163486,147.676327006136,0.0001037975122989,"lineage4","other_mutations_pyrazinamide","PRO",0,"ERR2041708","ERR2041708","lineage4","rs","Serbia","pnca_p.ala102pro","A","-","ALA","AA102","pnca_complex.pdb"
|
|
"A102P","L2","PZA","A","A102",102,"P",0,"Pre-XDR","OM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",3.5,-0.23,-1.249,-0.616782,-2.115,0.13,83,91,-0.862,8,8,10,0.0775193798449612,"loop",0.0333333333333332,5.51,0.0005749604714675,14.5802781289507,14.5802277940116,14.5801759034061,15.0663448164144,0,0,0,0,0,0,0,0,0,0,0,2,-2,0,0,0,0,-8,0,-2,-6,-6,0,-2,-5,-0.058257345491388,-0.322739018087855,-0.118584557409828,-0.360613810741688,0.0730337078651685,0.873684210526316,-0.71004942339374,"Destabilising","Destabilising","Stabilising","Destabilising","Stabilising","effect",-0.955,-0.827,"9:8","150/150","M:E:S:G:A:H:Q",2.6796663501904,0.0010245352377103,0.816050632122414,3.28370108999368,3.35697961122126,99.5538692592317,1.16376580853041,0.0005075351447614,3.29453387923245,2.60435121163486,147.676327006136,0.0001037975122989,"lineage2","other_mutations_pyrazinamide","PRO",0,"ERR552326","ERR552326","lineage2.2.1","","","pnca_p.ala102pro","A","-","ALA","AA102","pnca_complex.pdb"
|
|
"A102P","L4","PZA","A","A102",102,"P",NA,"MDR","OM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",3.5,-0.23,-1.249,-0.616782,-2.115,0.13,83,91,-0.862,8,8,10,0.0775193798449612,"loop",0.0333333333333332,5.51,0.0005749604714675,14.5802781289507,14.5802277940116,14.5801759034061,15.0663448164144,0,0,0,0,0,0,0,0,0,0,0,2,-2,0,0,0,0,-8,0,-2,-6,-6,0,-2,-5,-0.058257345491388,-0.322739018087855,-0.118584557409828,-0.360613810741688,0.0730337078651685,0.873684210526316,-0.71004942339374,"Destabilising","Destabilising","Stabilising","Destabilising","Stabilising","effect",-0.955,-0.827,"9:8","150/150","M:E:S:G:A:H:Q",2.6796663501904,0.0010245352377103,0.816050632122414,3.28370108999368,3.35697961122126,99.5538692592317,1.16376580853041,0.0005075351447614,3.29453387923245,2.60435121163486,147.676327006136,0.0001037975122989,"lineage4","other_mutations_pyrazinamide","PRO",0,"SAMN02419599","SRR1159180_SRR1162518_SRR1181126_SRR1180997","lineage4.2.1","by","Belarus","pnca_p.ala102pro","A","-","ALA","AA102","pnca_complex.pdb"
|
|
"A102P","L2","PZA","A","A102",102,"P",0,"Pre-XDR","OM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",3.5,-0.23,-1.249,-0.616782,-2.115,0.13,83,91,-0.862,8,8,10,0.0775193798449612,"loop",0.0333333333333332,5.51,0.0005749604714675,14.5802781289507,14.5802277940116,14.5801759034061,15.0663448164144,0,0,0,0,0,0,0,0,0,0,0,2,-2,0,0,0,0,-8,0,-2,-6,-6,0,-2,-5,-0.058257345491388,-0.322739018087855,-0.118584557409828,-0.360613810741688,0.0730337078651685,0.873684210526316,-0.71004942339374,"Destabilising","Destabilising","Stabilising","Destabilising","Stabilising","effect",-0.955,-0.827,"9:8","150/150","M:E:S:G:A:H:Q",2.6796663501904,0.0010245352377103,0.816050632122414,3.28370108999368,3.35697961122126,99.5538692592317,1.16376580853041,0.0005075351447614,3.29453387923245,2.60435121163486,147.676327006136,0.0001037975122989,"lineage2","other_mutations_pyrazinamide","PRO",0,"ERR133899,0653L-sc-2012-02-09T18:56:39Z-1355232","ERR133899","lineage2.2.1","ru","Russia,Samara","pnca_p.ala102pro","A","-","ALA","AA102","pnca_complex.pdb"
|
|
"A102P","L4","PZA","A","A102",102,"P",1,"XDR","OM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",3.5,-0.23,-1.249,-0.616782,-2.115,0.13,83,91,-0.862,8,8,10,0.0775193798449612,"loop",0.0333333333333332,5.51,0.0005749604714675,14.5802781289507,14.5802277940116,14.5801759034061,15.0663448164144,0,0,0,0,0,0,0,0,0,0,0,2,-2,0,0,0,0,-8,0,-2,-6,-6,0,-2,-5,-0.058257345491388,-0.322739018087855,-0.118584557409828,-0.360613810741688,0.0730337078651685,0.873684210526316,-0.71004942339374,"Destabilising","Destabilising","Stabilising","Destabilising","Stabilising","effect",-0.955,-0.827,"9:8","150/150","M:E:S:G:A:H:Q",2.6796663501904,0.0010245352377103,0.816050632122414,3.28370108999368,3.35697961122126,99.5538692592317,1.16376580853041,0.0005075351447614,3.29453387923245,2.60435121163486,147.676327006136,0.0001037975122989,"lineage4","other_mutations_pyrazinamide","PRO",0,"ERR2516668","ERR2516668","lineage4.3.3","pe","Peru","pnca_p.ala102pro","A","-","ALA","AA102","pnca_complex.pdb"
|
|
"A102P","L2","PZA","A","A102",102,"P",NA,"MDR","OM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",3.5,-0.23,-1.249,-0.616782,-2.115,0.13,83,91,-0.862,8,8,10,0.0775193798449612,"loop",0.0333333333333332,5.51,0.0005749604714675,14.5802781289507,14.5802277940116,14.5801759034061,15.0663448164144,0,0,0,0,0,0,0,0,0,0,0,2,-2,0,0,0,0,-8,0,-2,-6,-6,0,-2,-5,-0.058257345491388,-0.322739018087855,-0.118584557409828,-0.360613810741688,0.0730337078651685,0.873684210526316,-0.71004942339374,"Destabilising","Destabilising","Stabilising","Destabilising","Stabilising","effect",-0.955,-0.827,"9:8","150/150","M:E:S:G:A:H:Q",2.6796663501904,0.0010245352377103,0.816050632122414,3.28370108999368,3.35697961122126,99.5538692592317,1.16376580853041,0.0005075351447614,3.29453387923245,2.60435121163486,147.676327006136,0.0001037975122989,"lineage2","other_mutations_pyrazinamide","PRO",0,"SRS797282","SRR1723808","lineage2.2.1","cn","China:InnerMongolia","pnca_p.ala102pro","A","-","ALA","AA102","pnca_complex.pdb"
|
|
"A102P","L2","PZA","A","A102",102,"P",1,"XDR","OM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",3.5,-0.23,-1.249,-0.616782,-2.115,0.13,83,91,-0.862,8,8,10,0.0775193798449612,"loop",0.0333333333333332,5.51,0.0005749604714675,14.5802781289507,14.5802277940116,14.5801759034061,15.0663448164144,0,0,0,0,0,0,0,0,0,0,0,2,-2,0,0,0,0,-8,0,-2,-6,-6,0,-2,-5,-0.058257345491388,-0.322739018087855,-0.118584557409828,-0.360613810741688,0.0730337078651685,0.873684210526316,-0.71004942339374,"Destabilising","Destabilising","Stabilising","Destabilising","Stabilising","effect",-0.955,-0.827,"9:8","150/150","M:E:S:G:A:H:Q",2.6796663501904,0.0010245352377103,0.816050632122414,3.28370108999368,3.35697961122126,99.5538692592317,1.16376580853041,0.0005075351447614,3.29453387923245,2.60435121163486,147.676327006136,0.0001037975122989,"lineage2","other_mutations_pyrazinamide","PRO",0,"ERS2286300","ERR2503374","lineage2.2.1","fi","Finland","pnca_p.ala102pro","A","-","ALA","AA102","pnca_complex.pdb"
|
|
"A102P","L2","PZA","A","A102",102,"P",1,"MDR","OM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",3.5,-0.23,-1.249,-0.616782,-2.115,0.13,83,91,-0.862,8,8,10,0.0775193798449612,"loop",0.0333333333333332,5.51,0.0005749604714675,14.5802781289507,14.5802277940116,14.5801759034061,15.0663448164144,0,0,0,0,0,0,0,0,0,0,0,2,-2,0,0,0,0,-8,0,-2,-6,-6,0,-2,-5,-0.058257345491388,-0.322739018087855,-0.118584557409828,-0.360613810741688,0.0730337078651685,0.873684210526316,-0.71004942339374,"Destabilising","Destabilising","Stabilising","Destabilising","Stabilising","effect",-0.955,-0.827,"9:8","150/150","M:E:S:G:A:H:Q",2.6796663501904,0.0010245352377103,0.816050632122414,3.28370108999368,3.35697961122126,99.5538692592317,1.16376580853041,0.0005075351447614,3.29453387923245,2.60435121163486,147.676327006136,0.0001037975122989,"lineage2","other_mutations_pyrazinamide","PRO",0,"MDR_5112","SRR6824657","lineage2.2.1","cn","China: Huimin District, Huhhot City, Inner Mongolia Province","pnca_p.ala102pro","A","-","ALA","AA102","pnca_complex.pdb"
|
|
"A102P","L4","PZA","A","A102",102,"P",1,"Pre-XDR","OM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",3.5,-0.23,-1.249,-0.616782,-2.115,0.13,83,91,-0.862,8,8,10,0.0775193798449612,"loop",0.0333333333333332,5.51,0.0005749604714675,14.5802781289507,14.5802277940116,14.5801759034061,15.0663448164144,0,0,0,0,0,0,0,0,0,0,0,2,-2,0,0,0,0,-8,0,-2,-6,-6,0,-2,-5,-0.058257345491388,-0.322739018087855,-0.118584557409828,-0.360613810741688,0.0730337078651685,0.873684210526316,-0.71004942339374,"Destabilising","Destabilising","Stabilising","Destabilising","Stabilising","effect",-0.955,-0.827,"9:8","150/150","M:E:S:G:A:H:Q",2.6796663501904,0.0010245352377103,0.816050632122414,3.28370108999368,3.35697961122126,99.5538692592317,1.16376580853041,0.0005075351447614,3.29453387923245,2.60435121163486,147.676327006136,0.0001037975122989,"lineage4","other_mutations_pyrazinamide","PRO",0,"ERR2516572","ERR2516572","lineage4.3.4.2","pe","Peru","pnca_p.ala102pro","A","-","ALA","AA102","pnca_complex.pdb"
|
|
"A102P","L4","PZA","A","A102",102,"P",1,"XDR","OM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",3.5,-0.23,-1.249,-0.616782,-2.115,0.13,83,91,-0.862,8,8,10,0.0775193798449612,"loop",0.0333333333333332,5.51,0.0005749604714675,14.5802781289507,14.5802277940116,14.5801759034061,15.0663448164144,0,0,0,0,0,0,0,0,0,0,0,2,-2,0,0,0,0,-8,0,-2,-6,-6,0,-2,-5,-0.058257345491388,-0.322739018087855,-0.118584557409828,-0.360613810741688,0.0730337078651685,0.873684210526316,-0.71004942339374,"Destabilising","Destabilising","Stabilising","Destabilising","Stabilising","effect",-0.955,-0.827,"9:8","150/150","M:E:S:G:A:H:Q",2.6796663501904,0.0010245352377103,0.816050632122414,3.28370108999368,3.35697961122126,99.5538692592317,1.16376580853041,0.0005075351447614,3.29453387923245,2.60435121163486,147.676327006136,0.0001037975122989,"lineage4","other_mutations_pyrazinamide","PRO",0,"ERR2516628","ERR2516628","lineage4.3.3","pe","Peru","pnca_p.ala102pro","A","-","ALA","AA102","pnca_complex.pdb"
|
|
"A102R","L2","PZA","A","A102",102,"R",0,"Pre-XDR","OM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",3.5,0.174,-0.696,4.1344,-2.095,-0.28,81,91,-0.862,8,8,10,0.0775193798449612,"loop",0.0333333333333332,5.51,7.18700589334483e-05,2.42412778478352,0.0001249735077034,0,1.03410070803344e-29,-76,-30,0,0,-30,0,0,0,0,-2,0,0,-2,0,0,0,0,-12,0,-4,-10,-16,0,-12,-7,0.0780269058295964,-0.17984496124031,0.150583847493062,-0.357203751065644,-0.0732984293193717,0.852631578947368,-0.71004942339374,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.955,-0.827,"9:8","150/150","M:E:S:G:A:H:Q",-8.98740878149642,0.940032862253633,119.468044435492,-0.0752285585987749,NA,4692673.51081367,0.384555509373631,1,0,0,188.544222231268,0.999999999999997,"lineage2","other_mutations_pyrazinamide","ARG",0,"1323P-sc-2011-10-12T14:59:30Z-1289168,ERR108503","ERR108503","lineage2.2.1","ru","Russia,Samara","pnca_p.ala102arg","A","-","ALA","AA102","pnca_complex.pdb"
|
|
"A102T","L2","PZA","A","A102",102,"T",1,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",3.5,0.881,-0.719,-2.02927,-1.769,-0.2,71,85,-0.862,8,8,10,0.0775193798449612,"loop",0.0333333333333332,5.51,0.0001437401178668,19.411022297013,511754.463552419,Inf,4.73122070382274,-2,0,0,0,0,0,0,0,0,-2,0,0,-2,0,0,0,0,-5,0,-3,-3,-4,0,-2,-5,0.395067264573991,-0.18578811369509,-0.390154195185726,-0.301619778346121,-0.0523560209424083,0.747368421052632,-0.71004942339374,"Stabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.955,-0.827,"9:8","150/150","M:E:S:G:A:H:Q",13.1456002256202,0.924803768446987,139.277183326542,0.0943844491369395,0.0001628371344458,NA,1.28804840845689,0.0292235860951597,1.53426649183163,0.91081598550184,Inf,0.0296198560706035,"lineage2","dr_mutations_pyrazinamide","THR",0,"ERR234630,0365Y-sc-2012-10-11T13:37:02Z-1494116","ERR234630","lineage2.2.1","ru","Russia,Samara","pnca_p.ala102thr","A","-","ALA","AA102","pnca_complex.pdb"
|
|
"A102T","L3","PZA","A","A102",102,"T",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",3.5,0.881,-0.719,-2.02927,-1.769,-0.2,71,85,-0.862,8,8,10,0.0775193798449612,"loop",0.0333333333333332,5.51,0.0001437401178668,19.411022297013,511754.463552419,Inf,4.73122070382274,-2,0,0,0,0,0,0,0,0,-2,0,0,-2,0,0,0,0,-5,0,-3,-3,-4,0,-2,-5,0.395067264573991,-0.18578811369509,-0.390154195185726,-0.301619778346121,-0.0523560209424083,0.747368421052632,-0.71004942339374,"Stabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.955,-0.827,"9:8","150/150","M:E:S:G:A:H:Q",13.1456002256202,0.924803768446987,139.277183326542,0.0943844491369395,0.0001628371344458,NA,1.28804840845689,0.0292235860951597,1.53426649183163,0.91081598550184,Inf,0.0296198560706035,"lineage3","dr_mutations_pyrazinamide","THR",0,"ERR2245391","ERR2245391","lineage3.1.1","no","","pnca_p.ala102thr","A","-","ALA","AA102","pnca_complex.pdb"
|
|
"A102T","L4","PZA","A","A102",102,"T",1,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",3.5,0.881,-0.719,-2.02927,-1.769,-0.2,71,85,-0.862,8,8,10,0.0775193798449612,"loop",0.0333333333333332,5.51,0.0001437401178668,19.411022297013,511754.463552419,Inf,4.73122070382274,-2,0,0,0,0,0,0,0,0,-2,0,0,-2,0,0,0,0,-5,0,-3,-3,-4,0,-2,-5,0.395067264573991,-0.18578811369509,-0.390154195185726,-0.301619778346121,-0.0523560209424083,0.747368421052632,-0.71004942339374,"Stabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.955,-0.827,"9:8","150/150","M:E:S:G:A:H:Q",13.1456002256202,0.924803768446987,139.277183326542,0.0943844491369395,0.0001628371344458,NA,1.28804840845689,0.0292235860951597,1.53426649183163,0.91081598550184,Inf,0.0296198560706035,"lineage4","dr_mutations_pyrazinamide","THR",0,"ERR2516397","ERR2516397","lineage4.1.2","be","Belgium","pnca_p.ala102thr","A","-","ALA","AA102","pnca_complex.pdb"
|
|
"A102V","L2","PZA","A","A102",102,"V",NA,"MDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",3.5,-0.162,-0.251,-1.90987,-1.389,-0.73,73,85,-0.862,8,8,10,0.0775193798449612,"loop",0.0333333333333332,5.51,0.000646830530401,2.42613636363636,2.42613901795158,2.42593660187249,0.724684701500429,-2,-26,0,0,-26,0,0,0,0,0,0,0,0,0,0,0,0,-5,0,-3,-2,-4,0,-4,-3,-0.0410334346504559,-0.0648578811369509,-0.367197954318234,-0.236828644501279,-0.19109947643979,0.768421052631579,-0.71004942339374,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.955,-0.827,"9:8","150/150","M:E:S:G:A:H:Q",0.886301112240174,0.210089452509977,0.707162944655621,1.25331950569298,0.511701209936356,9.20262713399942,0.384915207210874,0.188417082130056,0.724879726073294,0.392299288705794,11.3662890368022,0.394611528192705,"lineage2","other_mutations_pyrazinamide","VAL",0,"ERR751361","ERR751361","lineage2.2.1","pe","","pnca_p.ala102val","A","-","ALA","AA102","pnca_complex.pdb"
|
|
"A102V","L4","PZA","A","A102",102,"V",NA,"MDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",3.5,-0.162,-0.251,-1.90987,-1.389,-0.73,73,85,-0.862,8,8,10,0.0775193798449612,"loop",0.0333333333333332,5.51,0.000646830530401,2.42613636363636,2.42613901795158,2.42593660187249,0.724684701500429,-2,-26,0,0,-26,0,0,0,0,0,0,0,0,0,0,0,0,-5,0,-3,-2,-4,0,-4,-3,-0.0410334346504559,-0.0648578811369509,-0.367197954318234,-0.236828644501279,-0.19109947643979,0.768421052631579,-0.71004942339374,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.955,-0.827,"9:8","150/150","M:E:S:G:A:H:Q",0.886301112240174,0.210089452509977,0.707162944655621,1.25331950569298,0.511701209936356,9.20262713399942,0.384915207210874,0.188417082130056,0.724879726073294,0.392299288705794,11.3662890368022,0.394611528192705,"lineage4","other_mutations_pyrazinamide","VAL",0,"SAMN02586037","SRR1196486_SRR1173321_SRR1184384_SRR1173499","lineage4.4.1.1","za","South Africa","pnca_p.ala102val","A","-","ALA","AA102","pnca_complex.pdb"
|
|
"A102V","L4","PZA","A","A102",102,"V",NA,"MDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",3.5,-0.162,-0.251,-1.90987,-1.389,-0.73,73,85,-0.862,8,8,10,0.0775193798449612,"loop",0.0333333333333332,5.51,0.000646830530401,2.42613636363636,2.42613901795158,2.42593660187249,0.724684701500429,-2,-26,0,0,-26,0,0,0,0,0,0,0,0,0,0,0,0,-5,0,-3,-2,-4,0,-4,-3,-0.0410334346504559,-0.0648578811369509,-0.367197954318234,-0.236828644501279,-0.19109947643979,0.768421052631579,-0.71004942339374,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.955,-0.827,"9:8","150/150","M:E:S:G:A:H:Q",0.886301112240174,0.210089452509977,0.707162944655621,1.25331950569298,0.511701209936356,9.20262713399942,0.384915207210874,0.188417082130056,0.724879726073294,0.392299288705794,11.3662890368022,0.394611528192705,"lineage4","other_mutations_pyrazinamide","VAL",0,"SAMN02403494","SRR1165244_SRR1173339_SRR1167324_SRR1173782","lineage4.4.1.1","za","South Africa","pnca_p.ala102val","A","-","ALA","AA102","pnca_complex.pdb"
|
|
"A102V","L4","PZA","A","A102",102,"V",NA,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",3.5,-0.162,-0.251,-1.90987,-1.389,-0.73,73,85,-0.862,8,8,10,0.0775193798449612,"loop",0.0333333333333332,5.51,0.000646830530401,2.42613636363636,2.42613901795158,2.42593660187249,0.724684701500429,-2,-26,0,0,-26,0,0,0,0,0,0,0,0,0,0,0,0,-5,0,-3,-2,-4,0,-4,-3,-0.0410334346504559,-0.0648578811369509,-0.367197954318234,-0.236828644501279,-0.19109947643979,0.768421052631579,-0.71004942339374,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.955,-0.827,"9:8","150/150","M:E:S:G:A:H:Q",0.886301112240174,0.210089452509977,0.707162944655621,1.25331950569298,0.511701209936356,9.20262713399942,0.384915207210874,0.188417082130056,0.724879726073294,0.392299288705794,11.3662890368022,0.394611528192705,"lineage4","other_mutations_pyrazinamide","VAL",0,"SAMN02403514","SRR1167316_SRR1165254_SRR1173187_SRR1173595","lineage4.4.1.1","za","South Africa","pnca_p.ala102val","A","-","ALA","AA102","pnca_complex.pdb"
|
|
"A102V","L2","PZA","A","A102",102,"V",NA,"MDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",3.5,-0.162,-0.251,-1.90987,-1.389,-0.73,73,85,-0.862,8,8,10,0.0775193798449612,"loop",0.0333333333333332,5.51,0.000646830530401,2.42613636363636,2.42613901795158,2.42593660187249,0.724684701500429,-2,-26,0,0,-26,0,0,0,0,0,0,0,0,0,0,0,0,-5,0,-3,-2,-4,0,-4,-3,-0.0410334346504559,-0.0648578811369509,-0.367197954318234,-0.236828644501279,-0.19109947643979,0.768421052631579,-0.71004942339374,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.955,-0.827,"9:8","150/150","M:E:S:G:A:H:Q",0.886301112240174,0.210089452509977,0.707162944655621,1.25331950569298,0.511701209936356,9.20262713399942,0.384915207210874,0.188417082130056,0.724879726073294,0.392299288705794,11.3662890368022,0.394611528192705,"lineage2","other_mutations_pyrazinamide","VAL",0,"SRR5067292","SRR5067292","lineage2.2.1","vn","Vietnam","pnca_p.ala102val","A","-","ALA","AA102","pnca_complex.pdb"
|
|
"A102V","L4","PZA","A","A102",102,"V",NA,"MDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",3.5,-0.162,-0.251,-1.90987,-1.389,-0.73,73,85,-0.862,8,8,10,0.0775193798449612,"loop",0.0333333333333332,5.51,0.000646830530401,2.42613636363636,2.42613901795158,2.42593660187249,0.724684701500429,-2,-26,0,0,-26,0,0,0,0,0,0,0,0,0,0,0,0,-5,0,-3,-2,-4,0,-4,-3,-0.0410334346504559,-0.0648578811369509,-0.367197954318234,-0.236828644501279,-0.19109947643979,0.768421052631579,-0.71004942339374,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.955,-0.827,"9:8","150/150","M:E:S:G:A:H:Q",0.886301112240174,0.210089452509977,0.707162944655621,1.25331950569298,0.511701209936356,9.20262713399942,0.384915207210874,0.188417082130056,0.724879726073294,0.392299288705794,11.3662890368022,0.394611528192705,"lineage4","other_mutations_pyrazinamide","VAL",0,"SRR5709781,SAMN07236346","SRR5709781","lineage4.2.2","th","Thailand","pnca_p.ala102val","A","-","ALA","AA102","pnca_complex.pdb"
|
|
"A102V","L1","PZA","A","A102",102,"V",NA,"Pre-MDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",3.5,-0.162,-0.251,-1.90987,-1.389,-0.73,73,85,-0.862,8,8,10,0.0775193798449612,"loop",0.0333333333333332,5.51,0.000646830530401,2.42613636363636,2.42613901795158,2.42593660187249,0.724684701500429,-2,-26,0,0,-26,0,0,0,0,0,0,0,0,0,0,0,0,-5,0,-3,-2,-4,0,-4,-3,-0.0410334346504559,-0.0648578811369509,-0.367197954318234,-0.236828644501279,-0.19109947643979,0.768421052631579,-0.71004942339374,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.955,-0.827,"9:8","150/150","M:E:S:G:A:H:Q",0.886301112240174,0.210089452509977,0.707162944655621,1.25331950569298,0.511701209936356,9.20262713399942,0.384915207210874,0.188417082130056,0.724879726073294,0.392299288705794,11.3662890368022,0.394611528192705,"lineage1","other_mutations_pyrazinamide","VAL",0,"SRR6398042","SRR6398042","lineage1.2.1","ca","Canada","pnca_p.ala102val","A","-","ALA","AA102","pnca_complex.pdb"
|
|
"A102V","L4","PZA","A","A102",102,"V",0,"MDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",3.5,-0.162,-0.251,-1.90987,-1.389,-0.73,73,85,-0.862,8,8,10,0.0775193798449612,"loop",0.0333333333333332,5.51,0.000646830530401,2.42613636363636,2.42613901795158,2.42593660187249,0.724684701500429,-2,-26,0,0,-26,0,0,0,0,0,0,0,0,0,0,0,0,-5,0,-3,-2,-4,0,-4,-3,-0.0410334346504559,-0.0648578811369509,-0.367197954318234,-0.236828644501279,-0.19109947643979,0.768421052631579,-0.71004942339374,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.955,-0.827,"9:8","150/150","M:E:S:G:A:H:Q",0.886301112240174,0.210089452509977,0.707162944655621,1.25331950569298,0.511701209936356,9.20262713399942,0.384915207210874,0.188417082130056,0.724879726073294,0.392299288705794,11.3662890368022,0.394611528192705,"lineage4","other_mutations_pyrazinamide","VAL",0,"SAMN02053755","SRR832977_SRR832997","lineage4.4.1.1","za","South Africa","pnca_p.ala102val","A","-","ALA","AA102","pnca_complex.pdb"
|
|
"A102V","L4","PZA","A","A102",102,"V",NA,"MDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",3.5,-0.162,-0.251,-1.90987,-1.389,-0.73,73,85,-0.862,8,8,10,0.0775193798449612,"loop",0.0333333333333332,5.51,0.000646830530401,2.42613636363636,2.42613901795158,2.42593660187249,0.724684701500429,-2,-26,0,0,-26,0,0,0,0,0,0,0,0,0,0,0,0,-5,0,-3,-2,-4,0,-4,-3,-0.0410334346504559,-0.0648578811369509,-0.367197954318234,-0.236828644501279,-0.19109947643979,0.768421052631579,-0.71004942339374,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.955,-0.827,"9:8","150/150","M:E:S:G:A:H:Q",0.886301112240174,0.210089452509977,0.707162944655621,1.25331950569298,0.511701209936356,9.20262713399942,0.384915207210874,0.188417082130056,0.724879726073294,0.392299288705794,11.3662890368022,0.394611528192705,"lineage4","other_mutations_pyrazinamide","VAL",0,"SAMN02403515","SRR1165266_SRR1167304_SRR1173786_SRR1173317","lineage4.4.1.1","za","South Africa","pnca_p.ala102val","A","-","ALA","AA102","pnca_complex.pdb"
|
|
"A102V","L4","PZA","A","A102",102,"V",0,"MDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",3.5,-0.162,-0.251,-1.90987,-1.389,-0.73,73,85,-0.862,8,8,10,0.0775193798449612,"loop",0.0333333333333332,5.51,0.000646830530401,2.42613636363636,2.42613901795158,2.42593660187249,0.724684701500429,-2,-26,0,0,-26,0,0,0,0,0,0,0,0,0,0,0,0,-5,0,-3,-2,-4,0,-4,-3,-0.0410334346504559,-0.0648578811369509,-0.367197954318234,-0.236828644501279,-0.19109947643979,0.768421052631579,-0.71004942339374,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.955,-0.827,"9:8","150/150","M:E:S:G:A:H:Q",0.886301112240174,0.210089452509977,0.707162944655621,1.25331950569298,0.511701209936356,9.20262713399942,0.384915207210874,0.188417082130056,0.724879726073294,0.392299288705794,11.3662890368022,0.394611528192705,"lineage4","other_mutations_pyrazinamide","VAL",0,"SAMN02053771","SRR833117_SRR833014","lineage4.4.1.1","za","South Africa","pnca_p.ala102val","A","-","ALA","AA102","pnca_complex.pdb"
|
|
"A102V","L4","PZA","A","A102",102,"V",NA,"MDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",3.5,-0.162,-0.251,-1.90987,-1.389,-0.73,73,85,-0.862,8,8,10,0.0775193798449612,"loop",0.0333333333333332,5.51,0.000646830530401,2.42613636363636,2.42613901795158,2.42593660187249,0.724684701500429,-2,-26,0,0,-26,0,0,0,0,0,0,0,0,0,0,0,0,-5,0,-3,-2,-4,0,-4,-3,-0.0410334346504559,-0.0648578811369509,-0.367197954318234,-0.236828644501279,-0.19109947643979,0.768421052631579,-0.71004942339374,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.955,-0.827,"9:8","150/150","M:E:S:G:A:H:Q",0.886301112240174,0.210089452509977,0.707162944655621,1.25331950569298,0.511701209936356,9.20262713399942,0.384915207210874,0.188417082130056,0.724879726073294,0.392299288705794,11.3662890368022,0.394611528192705,"lineage4","other_mutations_pyrazinamide","VAL",0,"SAMN02586004","SRR1184317_SRR1173063_SRR1196553_SRR1173353","lineage4.4.1.1","za","South Africa","pnca_p.ala102val","A","-","ALA","AA102","pnca_complex.pdb"
|
|
"A102V","L2","PZA","A","A102",102,"V",NA,"MDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",3.5,-0.162,-0.251,-1.90987,-1.389,-0.73,73,85,-0.862,8,8,10,0.0775193798449612,"loop",0.0333333333333332,5.51,0.000646830530401,2.42613636363636,2.42613901795158,2.42593660187249,0.724684701500429,-2,-26,0,0,-26,0,0,0,0,0,0,0,0,0,0,0,0,-5,0,-3,-2,-4,0,-4,-3,-0.0410334346504559,-0.0648578811369509,-0.367197954318234,-0.236828644501279,-0.19109947643979,0.768421052631579,-0.71004942339374,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.955,-0.827,"9:8","150/150","M:E:S:G:A:H:Q",0.886301112240174,0.210089452509977,0.707162944655621,1.25331950569298,0.511701209936356,9.20262713399942,0.384915207210874,0.188417082130056,0.724879726073294,0.392299288705794,11.3662890368022,0.394611528192705,"lineage2","other_mutations_pyrazinamide","VAL",0,"SRR5073555","SRR5073555","lineage2.2.1","vn","Vietnam","pnca_p.ala102val","A","-","ALA","AA102","pnca_complex.pdb"
|
|
"A102V","L4","PZA","A","A102",102,"V",NA,"MDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",3.5,-0.162,-0.251,-1.90987,-1.389,-0.73,73,85,-0.862,8,8,10,0.0775193798449612,"loop",0.0333333333333332,5.51,0.000646830530401,2.42613636363636,2.42613901795158,2.42593660187249,0.724684701500429,-2,-26,0,0,-26,0,0,0,0,0,0,0,0,0,0,0,0,-5,0,-3,-2,-4,0,-4,-3,-0.0410334346504559,-0.0648578811369509,-0.367197954318234,-0.236828644501279,-0.19109947643979,0.768421052631579,-0.71004942339374,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.955,-0.827,"9:8","150/150","M:E:S:G:A:H:Q",0.886301112240174,0.210089452509977,0.707162944655621,1.25331950569298,0.511701209936356,9.20262713399942,0.384915207210874,0.188417082130056,0.724879726073294,0.392299288705794,11.3662890368022,0.394611528192705,"lineage4","other_mutations_pyrazinamide","VAL",0,"SAMN02586002","SRR1196716_SRR1184385_SRR1172981_SRR1172777","lineage4.4.1.1","za","South Africa","pnca_p.ala102val","A","-","ALA","AA102","pnca_complex.pdb"
|
|
"A102V","L4","PZA","A","A102",102,"V",0,"MDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",3.5,-0.162,-0.251,-1.90987,-1.389,-0.73,73,85,-0.862,8,8,10,0.0775193798449612,"loop",0.0333333333333332,5.51,0.000646830530401,2.42613636363636,2.42613901795158,2.42593660187249,0.724684701500429,-2,-26,0,0,-26,0,0,0,0,0,0,0,0,0,0,0,0,-5,0,-3,-2,-4,0,-4,-3,-0.0410334346504559,-0.0648578811369509,-0.367197954318234,-0.236828644501279,-0.19109947643979,0.768421052631579,-0.71004942339374,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.955,-0.827,"9:8","150/150","M:E:S:G:A:H:Q",0.886301112240174,0.210089452509977,0.707162944655621,1.25331950569298,0.511701209936356,9.20262713399942,0.384915207210874,0.188417082130056,0.724879726073294,0.392299288705794,11.3662890368022,0.394611528192705,"lineage4","other_mutations_pyrazinamide","VAL",0,"ERR2041795","ERR2041795","lineage4.2.2.1","rs","Serbia","pnca_p.ala102val","A","-","ALA","AA102","pnca_complex.pdb"
|
|
"A102V","L4","PZA","A","A102",102,"V",NA,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",3.5,-0.162,-0.251,-1.90987,-1.389,-0.73,73,85,-0.862,8,8,10,0.0775193798449612,"loop",0.0333333333333332,5.51,0.000646830530401,2.42613636363636,2.42613901795158,2.42593660187249,0.724684701500429,-2,-26,0,0,-26,0,0,0,0,0,0,0,0,0,0,0,0,-5,0,-3,-2,-4,0,-4,-3,-0.0410334346504559,-0.0648578811369509,-0.367197954318234,-0.236828644501279,-0.19109947643979,0.768421052631579,-0.71004942339374,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.955,-0.827,"9:8","150/150","M:E:S:G:A:H:Q",0.886301112240174,0.210089452509977,0.707162944655621,1.25331950569298,0.511701209936356,9.20262713399942,0.384915207210874,0.188417082130056,0.724879726073294,0.392299288705794,11.3662890368022,0.394611528192705,"lineage4","other_mutations_pyrazinamide","VAL",0,"SAMN02403581","SRR1167345_SRR1165645_SRR1169217_SRR1169314","lineage4.4.1.1","za","South Africa","pnca_p.ala102val","A","-","ALA","AA102","pnca_complex.pdb"
|
|
"A102V","L4","PZA","A","A102",102,"V",1,"MDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",3.5,-0.162,-0.251,-1.90987,-1.389,-0.73,73,85,-0.862,8,8,10,0.0775193798449612,"loop",0.0333333333333332,5.51,0.000646830530401,2.42613636363636,2.42613901795158,2.42593660187249,0.724684701500429,-2,-26,0,0,-26,0,0,0,0,0,0,0,0,0,0,0,0,-5,0,-3,-2,-4,0,-4,-3,-0.0410334346504559,-0.0648578811369509,-0.367197954318234,-0.236828644501279,-0.19109947643979,0.768421052631579,-0.71004942339374,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.955,-0.827,"9:8","150/150","M:E:S:G:A:H:Q",0.886301112240174,0.210089452509977,0.707162944655621,1.25331950569298,0.511701209936356,9.20262713399942,0.384915207210874,0.188417082130056,0.724879726073294,0.392299288705794,11.3662890368022,0.394611528192705,"lineage4","other_mutations_pyrazinamide","VAL",0,"ERR2041709","ERR2041709","lineage4.2.2.1","rs","Serbia","pnca_p.ala102val","A","-","ALA","AA102","pnca_complex.pdb"
|
|
"A102V","L2","PZA","A","A102",102,"V",NA,"MDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",3.5,-0.162,-0.251,-1.90987,-1.389,-0.73,73,85,-0.862,8,8,10,0.0775193798449612,"loop",0.0333333333333332,5.51,0.000646830530401,2.42613636363636,2.42613901795158,2.42593660187249,0.724684701500429,-2,-26,0,0,-26,0,0,0,0,0,0,0,0,0,0,0,0,-5,0,-3,-2,-4,0,-4,-3,-0.0410334346504559,-0.0648578811369509,-0.367197954318234,-0.236828644501279,-0.19109947643979,0.768421052631579,-0.71004942339374,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.955,-0.827,"9:8","150/150","M:E:S:G:A:H:Q",0.886301112240174,0.210089452509977,0.707162944655621,1.25331950569298,0.511701209936356,9.20262713399942,0.384915207210874,0.188417082130056,0.724879726073294,0.392299288705794,11.3662890368022,0.394611528192705,"lineage2","other_mutations_pyrazinamide","VAL",0,"SRR5067558","SRR5067558","lineage2.2.1","vn","Vietnam","pnca_p.ala102val","A","-","ALA","AA102","pnca_complex.pdb"
|
|
"A102V","L4","PZA","A","A102",102,"V",NA,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",3.5,-0.162,-0.251,-1.90987,-1.389,-0.73,73,85,-0.862,8,8,10,0.0775193798449612,"loop",0.0333333333333332,5.51,0.000646830530401,2.42613636363636,2.42613901795158,2.42593660187249,0.724684701500429,-2,-26,0,0,-26,0,0,0,0,0,0,0,0,0,0,0,0,-5,0,-3,-2,-4,0,-4,-3,-0.0410334346504559,-0.0648578811369509,-0.367197954318234,-0.236828644501279,-0.19109947643979,0.768421052631579,-0.71004942339374,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.955,-0.827,"9:8","150/150","M:E:S:G:A:H:Q",0.886301112240174,0.210089452509977,0.707162944655621,1.25331950569298,0.511701209936356,9.20262713399942,0.384915207210874,0.188417082130056,0.724879726073294,0.392299288705794,11.3662890368022,0.394611528192705,"lineage4","other_mutations_pyrazinamide","VAL",0,"SAMN02350492","SRR1019160_SRR1140924","lineage4.4.1.1","za","South Africa","pnca_p.ala102val","A","-","ALA","AA102","pnca_complex.pdb"
|
|
"A102V","L4","PZA","A","A102",102,"V",0,"MDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",3.5,-0.162,-0.251,-1.90987,-1.389,-0.73,73,85,-0.862,8,8,10,0.0775193798449612,"loop",0.0333333333333332,5.51,0.000646830530401,2.42613636363636,2.42613901795158,2.42593660187249,0.724684701500429,-2,-26,0,0,-26,0,0,0,0,0,0,0,0,0,0,0,0,-5,0,-3,-2,-4,0,-4,-3,-0.0410334346504559,-0.0648578811369509,-0.367197954318234,-0.236828644501279,-0.19109947643979,0.768421052631579,-0.71004942339374,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.955,-0.827,"9:8","150/150","M:E:S:G:A:H:Q",0.886301112240174,0.210089452509977,0.707162944655621,1.25331950569298,0.511701209936356,9.20262713399942,0.384915207210874,0.188417082130056,0.724879726073294,0.392299288705794,11.3662890368022,0.394611528192705,"lineage4","other_mutations_pyrazinamide","VAL",0,"ERR2041798","ERR2041798","lineage4.2.2.1","rs","Serbia","pnca_p.ala102val","A","-","ALA","AA102","pnca_complex.pdb"
|
|
"A102V","L4","PZA","A","A102",102,"V",NA,"MDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",3.5,-0.162,-0.251,-1.90987,-1.389,-0.73,73,85,-0.862,8,8,10,0.0775193798449612,"loop",0.0333333333333332,5.51,0.000646830530401,2.42613636363636,2.42613901795158,2.42593660187249,0.724684701500429,-2,-26,0,0,-26,0,0,0,0,0,0,0,0,0,0,0,0,-5,0,-3,-2,-4,0,-4,-3,-0.0410334346504559,-0.0648578811369509,-0.367197954318234,-0.236828644501279,-0.19109947643979,0.768421052631579,-0.71004942339374,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.955,-0.827,"9:8","150/150","M:E:S:G:A:H:Q",0.886301112240174,0.210089452509977,0.707162944655621,1.25331950569298,0.511701209936356,9.20262713399942,0.384915207210874,0.188417082130056,0.724879726073294,0.392299288705794,11.3662890368022,0.394611528192705,"lineage4","other_mutations_pyrazinamide","VAL",0,"SAMN02403580","SRR1169148_SRR1167342_SRR1172353_SRR1165668","lineage4.4.1.1","za","South Africa","pnca_p.ala102val","A","-","ALA","AA102","pnca_complex.pdb"
|
|
"A102V","L4","PZA","A","A102",102,"V",NA,"MDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",3.5,-0.162,-0.251,-1.90987,-1.389,-0.73,73,85,-0.862,8,8,10,0.0775193798449612,"loop",0.0333333333333332,5.51,0.000646830530401,2.42613636363636,2.42613901795158,2.42593660187249,0.724684701500429,-2,-26,0,0,-26,0,0,0,0,0,0,0,0,0,0,0,0,-5,0,-3,-2,-4,0,-4,-3,-0.0410334346504559,-0.0648578811369509,-0.367197954318234,-0.236828644501279,-0.19109947643979,0.768421052631579,-0.71004942339374,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.955,-0.827,"9:8","150/150","M:E:S:G:A:H:Q",0.886301112240174,0.210089452509977,0.707162944655621,1.25331950569298,0.511701209936356,9.20262713399942,0.384915207210874,0.188417082130056,0.724879726073294,0.392299288705794,11.3662890368022,0.394611528192705,"lineage4","other_mutations_pyrazinamide","VAL",0,"SAMN02586000","SRR1173545_SRR1173095_SRR1184309_SRR1196558","lineage4.4.1.1","za","South Africa","pnca_p.ala102val","A","-","ALA","AA102","pnca_complex.pdb"
|
|
"A102V","L4","PZA","A","A102",102,"V",0,"MDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",3.5,-0.162,-0.251,-1.90987,-1.389,-0.73,73,85,-0.862,8,8,10,0.0775193798449612,"loop",0.0333333333333332,5.51,0.000646830530401,2.42613636363636,2.42613901795158,2.42593660187249,0.724684701500429,-2,-26,0,0,-26,0,0,0,0,0,0,0,0,0,0,0,0,-5,0,-3,-2,-4,0,-4,-3,-0.0410334346504559,-0.0648578811369509,-0.367197954318234,-0.236828644501279,-0.19109947643979,0.768421052631579,-0.71004942339374,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.955,-0.827,"9:8","150/150","M:E:S:G:A:H:Q",0.886301112240174,0.210089452509977,0.707162944655621,1.25331950569298,0.511701209936356,9.20262713399942,0.384915207210874,0.188417082130056,0.724879726073294,0.392299288705794,11.3662890368022,0.394611528192705,"lineage4","other_mutations_pyrazinamide","VAL",0,"ERR2515242","ERR2515242","lineage4.4.1.1","za","South Africa","pnca_p.ala102val","A","-","ALA","AA102","pnca_complex.pdb"
|
|
"A102V","L4","PZA","A","A102",102,"V",1,"MDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",3.5,-0.162,-0.251,-1.90987,-1.389,-0.73,73,85,-0.862,8,8,10,0.0775193798449612,"loop",0.0333333333333332,5.51,0.000646830530401,2.42613636363636,2.42613901795158,2.42593660187249,0.724684701500429,-2,-26,0,0,-26,0,0,0,0,0,0,0,0,0,0,0,0,-5,0,-3,-2,-4,0,-4,-3,-0.0410334346504559,-0.0648578811369509,-0.367197954318234,-0.236828644501279,-0.19109947643979,0.768421052631579,-0.71004942339374,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.955,-0.827,"9:8","150/150","M:E:S:G:A:H:Q",0.886301112240174,0.210089452509977,0.707162944655621,1.25331950569298,0.511701209936356,9.20262713399942,0.384915207210874,0.188417082130056,0.724879726073294,0.392299288705794,11.3662890368022,0.394611528192705,"lineage4","other_mutations_pyrazinamide","VAL",0,"ERR2041688","ERR2041688","lineage4.2.2.1","rs","Serbia","pnca_p.ala102val","A","-","ALA","AA102","pnca_complex.pdb"
|
|
"A102V","L4","PZA","A","A102",102,"V",1,"MDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",3.5,-0.162,-0.251,-1.90987,-1.389,-0.73,73,85,-0.862,8,8,10,0.0775193798449612,"loop",0.0333333333333332,5.51,0.000646830530401,2.42613636363636,2.42613901795158,2.42593660187249,0.724684701500429,-2,-26,0,0,-26,0,0,0,0,0,0,0,0,0,0,0,0,-5,0,-3,-2,-4,0,-4,-3,-0.0410334346504559,-0.0648578811369509,-0.367197954318234,-0.236828644501279,-0.19109947643979,0.768421052631579,-0.71004942339374,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.955,-0.827,"9:8","150/150","M:E:S:G:A:H:Q",0.886301112240174,0.210089452509977,0.707162944655621,1.25331950569298,0.511701209936356,9.20262713399942,0.384915207210874,0.188417082130056,0.724879726073294,0.392299288705794,11.3662890368022,0.394611528192705,"lineage4","other_mutations_pyrazinamide","VAL",0,"ERR2041777","ERR2041777","lineage4.2.2.1","rs","Serbia","pnca_p.ala102val","A","-","ALA","AA102","pnca_complex.pdb"
|
|
"A102V","L4","PZA","A","A102",102,"V",NA,"MDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",3.5,-0.162,-0.251,-1.90987,-1.389,-0.73,73,85,-0.862,8,8,10,0.0775193798449612,"loop",0.0333333333333332,5.51,0.000646830530401,2.42613636363636,2.42613901795158,2.42593660187249,0.724684701500429,-2,-26,0,0,-26,0,0,0,0,0,0,0,0,0,0,0,0,-5,0,-3,-2,-4,0,-4,-3,-0.0410334346504559,-0.0648578811369509,-0.367197954318234,-0.236828644501279,-0.19109947643979,0.768421052631579,-0.71004942339374,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.955,-0.827,"9:8","150/150","M:E:S:G:A:H:Q",0.886301112240174,0.210089452509977,0.707162944655621,1.25331950569298,0.511701209936356,9.20262713399942,0.384915207210874,0.188417082130056,0.724879726073294,0.392299288705794,11.3662890368022,0.394611528192705,"lineage4","other_mutations_pyrazinamide","VAL",0,"SAMN02403495","SRR1165273_SRR1175355_SRR1173150_SRR1167262","lineage4.4.1.1","za","South Africa","pnca_p.ala102val","A","-","ALA","AA102","pnca_complex.pdb"
|
|
"A102V","L4","PZA","A","A102",102,"V",NA,"MDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",3.5,-0.162,-0.251,-1.90987,-1.389,-0.73,73,85,-0.862,8,8,10,0.0775193798449612,"loop",0.0333333333333332,5.51,0.000646830530401,2.42613636363636,2.42613901795158,2.42593660187249,0.724684701500429,-2,-26,0,0,-26,0,0,0,0,0,0,0,0,0,0,0,0,-5,0,-3,-2,-4,0,-4,-3,-0.0410334346504559,-0.0648578811369509,-0.367197954318234,-0.236828644501279,-0.19109947643979,0.768421052631579,-0.71004942339374,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.955,-0.827,"9:8","150/150","M:E:S:G:A:H:Q",0.886301112240174,0.210089452509977,0.707162944655621,1.25331950569298,0.511701209936356,9.20262713399942,0.384915207210874,0.188417082130056,0.724879726073294,0.392299288705794,11.3662890368022,0.394611528192705,"lineage4","other_mutations_pyrazinamide","VAL",0,"SAMN02403535","SRR1169310_SRR1165620_SRR1167344_SRR1169220","lineage4.4.1.1","za","South Africa","pnca_p.ala102val","A","-","ALA","AA102","pnca_complex.pdb"
|
|
"A102V","L4","PZA","A","A102",102,"V",NA,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",3.5,-0.162,-0.251,-1.90987,-1.389,-0.73,73,85,-0.862,8,8,10,0.0775193798449612,"loop",0.0333333333333332,5.51,0.000646830530401,2.42613636363636,2.42613901795158,2.42593660187249,0.724684701500429,-2,-26,0,0,-26,0,0,0,0,0,0,0,0,0,0,0,0,-5,0,-3,-2,-4,0,-4,-3,-0.0410334346504559,-0.0648578811369509,-0.367197954318234,-0.236828644501279,-0.19109947643979,0.768421052631579,-0.71004942339374,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.955,-0.827,"9:8","150/150","M:E:S:G:A:H:Q",0.886301112240174,0.210089452509977,0.707162944655621,1.25331950569298,0.511701209936356,9.20262713399942,0.384915207210874,0.188417082130056,0.724879726073294,0.392299288705794,11.3662890368022,0.394611528192705,"lineage4","other_mutations_pyrazinamide","VAL",0,"SAMN01925652","SRR924221_SRR847797","lineage4.4.1.1","za","South Africa","pnca_p.ala102val","A","-","ALA","AA102","pnca_complex.pdb"
|
|
"A102V","L4","PZA","A","A102",102,"V",NA,"MDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",3.5,-0.162,-0.251,-1.90987,-1.389,-0.73,73,85,-0.862,8,8,10,0.0775193798449612,"loop",0.0333333333333332,5.51,0.000646830530401,2.42613636363636,2.42613901795158,2.42593660187249,0.724684701500429,-2,-26,0,0,-26,0,0,0,0,0,0,0,0,0,0,0,0,-5,0,-3,-2,-4,0,-4,-3,-0.0410334346504559,-0.0648578811369509,-0.367197954318234,-0.236828644501279,-0.19109947643979,0.768421052631579,-0.71004942339374,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.955,-0.827,"9:8","150/150","M:E:S:G:A:H:Q",0.886301112240174,0.210089452509977,0.707162944655621,1.25331950569298,0.511701209936356,9.20262713399942,0.384915207210874,0.188417082130056,0.724879726073294,0.392299288705794,11.3662890368022,0.394611528192705,"lineage4","other_mutations_pyrazinamide","VAL",0,"ERR2515636","ERR2515636","lineage4.4.1.1","za","South Africa","pnca_p.ala102val","A","-","ALA","AA102","pnca_complex.pdb"
|
|
"A102V","L4","PZA","A","A102",102,"V",NA,"MDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",3.5,-0.162,-0.251,-1.90987,-1.389,-0.73,73,85,-0.862,8,8,10,0.0775193798449612,"loop",0.0333333333333332,5.51,0.000646830530401,2.42613636363636,2.42613901795158,2.42593660187249,0.724684701500429,-2,-26,0,0,-26,0,0,0,0,0,0,0,0,0,0,0,0,-5,0,-3,-2,-4,0,-4,-3,-0.0410334346504559,-0.0648578811369509,-0.367197954318234,-0.236828644501279,-0.19109947643979,0.768421052631579,-0.71004942339374,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.955,-0.827,"9:8","150/150","M:E:S:G:A:H:Q",0.886301112240174,0.210089452509977,0.707162944655621,1.25331950569298,0.511701209936356,9.20262713399942,0.384915207210874,0.188417082130056,0.724879726073294,0.392299288705794,11.3662890368022,0.394611528192705,"lineage4","other_mutations_pyrazinamide","VAL",0,"SAMN02053774","SRR833017_SRR833018","lineage4.4.1.1","za","South Africa","pnca_p.ala102val","A","-","ALA","AA102","pnca_complex.pdb"
|
|
"A102V","L2","PZA","A","A102",102,"V",0,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",3.5,-0.162,-0.251,-1.90987,-1.389,-0.73,73,85,-0.862,8,8,10,0.0775193798449612,"loop",0.0333333333333332,5.51,0.000646830530401,2.42613636363636,2.42613901795158,2.42593660187249,0.724684701500429,-2,-26,0,0,-26,0,0,0,0,0,0,0,0,0,0,0,0,-5,0,-3,-2,-4,0,-4,-3,-0.0410334346504559,-0.0648578811369509,-0.367197954318234,-0.236828644501279,-0.19109947643979,0.768421052631579,-0.71004942339374,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.955,-0.827,"9:8","150/150","M:E:S:G:A:H:Q",0.886301112240174,0.210089452509977,0.707162944655621,1.25331950569298,0.511701209936356,9.20262713399942,0.384915207210874,0.188417082130056,0.724879726073294,0.392299288705794,11.3662890368022,0.394611528192705,"lineage2","other_mutations_pyrazinamide","VAL",0,"ERR027448","ERR027448","lineage2.2.1","ru","Russia","pnca_p.ala102val","A","-","ALA","AA102","pnca_complex.pdb"
|
|
"A102V","L4","PZA","A","A102",102,"V",NA,"MDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",3.5,-0.162,-0.251,-1.90987,-1.389,-0.73,73,85,-0.862,8,8,10,0.0775193798449612,"loop",0.0333333333333332,5.51,0.000646830530401,2.42613636363636,2.42613901795158,2.42593660187249,0.724684701500429,-2,-26,0,0,-26,0,0,0,0,0,0,0,0,0,0,0,0,-5,0,-3,-2,-4,0,-4,-3,-0.0410334346504559,-0.0648578811369509,-0.367197954318234,-0.236828644501279,-0.19109947643979,0.768421052631579,-0.71004942339374,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.955,-0.827,"9:8","150/150","M:E:S:G:A:H:Q",0.886301112240174,0.210089452509977,0.707162944655621,1.25331950569298,0.511701209936356,9.20262713399942,0.384915207210874,0.188417082130056,0.724879726073294,0.392299288705794,11.3662890368022,0.394611528192705,"lineage4","other_mutations_pyrazinamide","VAL",0,"SAMN02350474","SRR1140899_SRR1019153","lineage4.4.1.1","za","South Africa","pnca_p.ala102val","A","-","ALA","AA102","pnca_complex.pdb"
|
|
"Y103C","L4","PZA","Y","Y103",103,"C",0,"Pre-MDR","DM","hydrophobic","hydrophobic","neutral","neutral","polar","non-polar",5.416,-0.48,0.606,1.02924,-0.498,1.43,68,80,-1.175,9,9,138,0.524714828897338,"loop",-0.1,3.94,0.0007187005893344,3.23621052631579,3.23621068095208,3.23583471755484,2.2626260572101,42,4,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-2,2,0,0,-2,0,-0.121580547112462,0.51530612244898,0.0374871611827009,-0.0849104859335038,0.803370786516854,0.715789473684211,-0.967874794069193,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.221,-1.152,"9:9","150/150","Y:K",1.17440310243918,0.0690022741521524,0.64584247435876,1.8184048728062,0.826804878959969,11.3377530375619,0.510036766167445,0.0754031320762053,1.12261061414134,0.671078964694216,13.6617156135614,0.132529157572648,"lineage4","dr_mutations_pyrazinamide","CYS",0,"ERR2516653","ERR2516653","lineage4.8","nl","Netherlands","pnca_p.tyr103cys","A","-","TYR","YA103","pnca_complex.pdb"
|
|
"Y103C","L4","PZA","Y","Y103",103,"C",1,"Pre-XDR","DM","hydrophobic","hydrophobic","neutral","neutral","polar","non-polar",5.416,-0.48,0.606,1.02924,-0.498,1.43,68,80,-1.175,9,9,138,0.524714828897338,"loop",-0.1,3.94,0.0007187005893344,3.23621052631579,3.23621068095208,3.23583471755484,2.2626260572101,42,4,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-2,2,0,0,-2,0,-0.121580547112462,0.51530612244898,0.0374871611827009,-0.0849104859335038,0.803370786516854,0.715789473684211,-0.967874794069193,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.221,-1.152,"9:9","150/150","Y:K",1.17440310243918,0.0690022741521524,0.64584247435876,1.8184048728062,0.826804878959969,11.3377530375619,0.510036766167445,0.0754031320762053,1.12261061414134,0.671078964694216,13.6617156135614,0.132529157572648,"lineage4","dr_mutations_pyrazinamide","CYS",0,"ERR2516632","ERR2516632","lineage4.8","pe","Peru","pnca_p.tyr103cys","A","-","TYR","YA103","pnca_complex.pdb"
|
|
"Y103C","L3","PZA","Y","Y103",103,"C",0,"Pre-MDR","DM","hydrophobic","hydrophobic","neutral","neutral","polar","non-polar",5.416,-0.48,0.606,1.02924,-0.498,1.43,68,80,-1.175,9,9,138,0.524714828897338,"loop",-0.1,3.94,0.0007187005893344,3.23621052631579,3.23621068095208,3.23583471755484,2.2626260572101,42,4,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-2,2,0,0,-2,0,-0.121580547112462,0.51530612244898,0.0374871611827009,-0.0849104859335038,0.803370786516854,0.715789473684211,-0.967874794069193,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.221,-1.152,"9:9","150/150","Y:K",1.17440310243918,0.0690022741521524,0.64584247435876,1.8184048728062,0.826804878959969,11.3377530375619,0.510036766167445,0.0754031320762053,1.12261061414134,0.671078964694216,13.6617156135614,0.132529157572648,"lineage3","dr_mutations_pyrazinamide","CYS",0,"ERR2510631","ERR2510631","lineage3","pk","Pakistan","pnca_p.tyr103cys","A","-","TYR","YA103","pnca_complex.pdb"
|
|
"Y103C","L2","PZA","Y","Y103",103,"C",0,"XDR","DM","hydrophobic","hydrophobic","neutral","neutral","polar","non-polar",5.416,-0.48,0.606,1.02924,-0.498,1.43,68,80,-1.175,9,9,138,0.524714828897338,"loop",-0.1,3.94,0.0007187005893344,3.23621052631579,3.23621068095208,3.23583471755484,2.2626260572101,42,4,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-2,2,0,0,-2,0,-0.121580547112462,0.51530612244898,0.0374871611827009,-0.0849104859335038,0.803370786516854,0.715789473684211,-0.967874794069193,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.221,-1.152,"9:9","150/150","Y:K",1.17440310243918,0.0690022741521524,0.64584247435876,1.8184048728062,0.826804878959969,11.3377530375619,0.510036766167445,0.0754031320762053,1.12261061414134,0.671078964694216,13.6617156135614,0.132529157572648,"lineage2","dr_mutations_pyrazinamide","CYS",0,"ERR067671,0911R-sc-2011-09-07T13:19:44Z-1276518","ERR067671","lineage2.2.1","ru","Russia,Samara","pnca_p.tyr103cys","A","-","TYR","YA103","pnca_complex.pdb"
|
|
"Y103C","L4","PZA","Y","Y103",103,"C",NA,"Pre-MDR","DM","hydrophobic","hydrophobic","neutral","neutral","polar","non-polar",5.416,-0.48,0.606,1.02924,-0.498,1.43,68,80,-1.175,9,9,138,0.524714828897338,"loop",-0.1,3.94,0.0007187005893344,3.23621052631579,3.23621068095208,3.23583471755484,2.2626260572101,42,4,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-2,2,0,0,-2,0,-0.121580547112462,0.51530612244898,0.0374871611827009,-0.0849104859335038,0.803370786516854,0.715789473684211,-0.967874794069193,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.221,-1.152,"9:9","150/150","Y:K",1.17440310243918,0.0690022741521524,0.64584247435876,1.8184048728062,0.826804878959969,11.3377530375619,0.510036766167445,0.0754031320762053,1.12261061414134,0.671078964694216,13.6617156135614,0.132529157572648,"lineage4","dr_mutations_pyrazinamide","CYS",0,"ERR2516439","ERR2516439","lineage4.8","nl","Netherlands","pnca_p.tyr103cys","A","-","TYR","YA103","pnca_complex.pdb"
|
|
"Y103C","L4","PZA","Y","Y103",103,"C",1,"MDR","DM","hydrophobic","hydrophobic","neutral","neutral","polar","non-polar",5.416,-0.48,0.606,1.02924,-0.498,1.43,68,80,-1.175,9,9,138,0.524714828897338,"loop",-0.1,3.94,0.0007187005893344,3.23621052631579,3.23621068095208,3.23583471755484,2.2626260572101,42,4,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-2,2,0,0,-2,0,-0.121580547112462,0.51530612244898,0.0374871611827009,-0.0849104859335038,0.803370786516854,0.715789473684211,-0.967874794069193,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.221,-1.152,"9:9","150/150","Y:K",1.17440310243918,0.0690022741521524,0.64584247435876,1.8184048728062,0.826804878959969,11.3377530375619,0.510036766167445,0.0754031320762053,1.12261061414134,0.671078964694216,13.6617156135614,0.132529157572648,"lineage4","dr_mutations_pyrazinamide","CYS",0,"ERR2510670","ERR2510670","lineage4.9","it","Italy","pnca_p.tyr103cys","A","-","TYR","YA103","pnca_complex.pdb"
|
|
"Y103C","L2","PZA","Y","Y103",103,"C",1,"MDR","DM","hydrophobic","hydrophobic","neutral","neutral","polar","non-polar",5.416,-0.48,0.606,1.02924,-0.498,1.43,68,80,-1.175,9,9,138,0.524714828897338,"loop",-0.1,3.94,0.0007187005893344,3.23621052631579,3.23621068095208,3.23583471755484,2.2626260572101,42,4,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-2,2,0,0,-2,0,-0.121580547112462,0.51530612244898,0.0374871611827009,-0.0849104859335038,0.803370786516854,0.715789473684211,-0.967874794069193,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.221,-1.152,"9:9","150/150","Y:K",1.17440310243918,0.0690022741521524,0.64584247435876,1.8184048728062,0.826804878959969,11.3377530375619,0.510036766167445,0.0754031320762053,1.12261061414134,0.671078964694216,13.6617156135614,0.132529157572648,"lineage2","dr_mutations_pyrazinamide","CYS",0,"ERR2516367","ERR2516367","lineage2.2.1","be","Belgium","pnca_p.tyr103cys","A","-","TYR","YA103","pnca_complex.pdb"
|
|
"Y103C","L4","PZA","Y","Y103",103,"C",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","neutral","neutral","polar","non-polar",5.416,-0.48,0.606,1.02924,-0.498,1.43,68,80,-1.175,9,9,138,0.524714828897338,"loop",-0.1,3.94,0.0007187005893344,3.23621052631579,3.23621068095208,3.23583471755484,2.2626260572101,42,4,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-2,2,0,0,-2,0,-0.121580547112462,0.51530612244898,0.0374871611827009,-0.0849104859335038,0.803370786516854,0.715789473684211,-0.967874794069193,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.221,-1.152,"9:9","150/150","Y:K",1.17440310243918,0.0690022741521524,0.64584247435876,1.8184048728062,0.826804878959969,11.3377530375619,0.510036766167445,0.0754031320762053,1.12261061414134,0.671078964694216,13.6617156135614,0.132529157572648,"lineage4","dr_mutations_pyrazinamide","CYS",0,"ERR751601","ERR751601","lineage4","pe","","pnca_p.tyr103cys","A","-","TYR","YA103","pnca_complex.pdb"
|
|
"Y103C","L4","PZA","Y","Y103",103,"C",NA,"XDR","DM","hydrophobic","hydrophobic","neutral","neutral","polar","non-polar",5.416,-0.48,0.606,1.02924,-0.498,1.43,68,80,-1.175,9,9,138,0.524714828897338,"loop",-0.1,3.94,0.0007187005893344,3.23621052631579,3.23621068095208,3.23583471755484,2.2626260572101,42,4,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-2,2,0,0,-2,0,-0.121580547112462,0.51530612244898,0.0374871611827009,-0.0849104859335038,0.803370786516854,0.715789473684211,-0.967874794069193,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.221,-1.152,"9:9","150/150","Y:K",1.17440310243918,0.0690022741521524,0.64584247435876,1.8184048728062,0.826804878959969,11.3377530375619,0.510036766167445,0.0754031320762053,1.12261061414134,0.671078964694216,13.6617156135614,0.132529157572648,"lineage4","dr_mutations_pyrazinamide","CYS",0,"ERR751620","ERR751620","lineage4","pe","","pnca_p.tyr103cys","A","-","TYR","YA103","pnca_complex.pdb"
|
|
"Y103C","L4","PZA","Y","Y103",103,"C",NA,"MDR","DM","hydrophobic","hydrophobic","neutral","neutral","polar","non-polar",5.416,-0.48,0.606,1.02924,-0.498,1.43,68,80,-1.175,9,9,138,0.524714828897338,"loop",-0.1,3.94,0.0007187005893344,3.23621052631579,3.23621068095208,3.23583471755484,2.2626260572101,42,4,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-2,2,0,0,-2,0,-0.121580547112462,0.51530612244898,0.0374871611827009,-0.0849104859335038,0.803370786516854,0.715789473684211,-0.967874794069193,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.221,-1.152,"9:9","150/150","Y:K",1.17440310243918,0.0690022741521524,0.64584247435876,1.8184048728062,0.826804878959969,11.3377530375619,0.510036766167445,0.0754031320762053,1.12261061414134,0.671078964694216,13.6617156135614,0.132529157572648,"lineage4","dr_mutations_pyrazinamide","CYS",0,"SAMN02584606","SRR1168962_SRR1166193","lineage4.3.3","md","Moldova","pnca_p.tyr103cys","A","-","TYR","YA103","pnca_complex.pdb"
|
|
"Y103C","L4","PZA","Y","Y103",103,"C",0,"Pre-MDR","DM","hydrophobic","hydrophobic","neutral","neutral","polar","non-polar",5.416,-0.48,0.606,1.02924,-0.498,1.43,68,80,-1.175,9,9,138,0.524714828897338,"loop",-0.1,3.94,0.0007187005893344,3.23621052631579,3.23621068095208,3.23583471755484,2.2626260572101,42,4,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-2,2,0,0,-2,0,-0.121580547112462,0.51530612244898,0.0374871611827009,-0.0849104859335038,0.803370786516854,0.715789473684211,-0.967874794069193,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.221,-1.152,"9:9","150/150","Y:K",1.17440310243918,0.0690022741521524,0.64584247435876,1.8184048728062,0.826804878959969,11.3377530375619,0.510036766167445,0.0754031320762053,1.12261061414134,0.671078964694216,13.6617156135614,0.132529157572648,"lineage4","dr_mutations_pyrazinamide","CYS",0,"ERR2516722","ERR2516722","lineage4.8","nl","Netherlands","pnca_p.tyr103cys","A","-","TYR","YA103","pnca_complex.pdb"
|
|
"Y103C","L2","PZA","Y","Y103",103,"C",0,"MDR","DM","hydrophobic","hydrophobic","neutral","neutral","polar","non-polar",5.416,-0.48,0.606,1.02924,-0.498,1.43,68,80,-1.175,9,9,138,0.524714828897338,"loop",-0.1,3.94,0.0007187005893344,3.23621052631579,3.23621068095208,3.23583471755484,2.2626260572101,42,4,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-2,2,0,0,-2,0,-0.121580547112462,0.51530612244898,0.0374871611827009,-0.0849104859335038,0.803370786516854,0.715789473684211,-0.967874794069193,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.221,-1.152,"9:9","150/150","Y:K",1.17440310243918,0.0690022741521524,0.64584247435876,1.8184048728062,0.826804878959969,11.3377530375619,0.510036766167445,0.0754031320762053,1.12261061414134,0.671078964694216,13.6617156135614,0.132529157572648,"lineage2","dr_mutations_pyrazinamide","CYS",0,"MDR_18428","SRR6824520","lineage2.2.1","cn","China: Taojiang County, Yiyang City, Hunan Province","pnca_p.tyr103cys","A","-","TYR","YA103","pnca_complex.pdb"
|
|
"Y103C","L4","PZA","Y","Y103",103,"C",1,"MDR","DM","hydrophobic","hydrophobic","neutral","neutral","polar","non-polar",5.416,-0.48,0.606,1.02924,-0.498,1.43,68,80,-1.175,9,9,138,0.524714828897338,"loop",-0.1,3.94,0.0007187005893344,3.23621052631579,3.23621068095208,3.23583471755484,2.2626260572101,42,4,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-2,2,0,0,-2,0,-0.121580547112462,0.51530612244898,0.0374871611827009,-0.0849104859335038,0.803370786516854,0.715789473684211,-0.967874794069193,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.221,-1.152,"9:9","150/150","Y:K",1.17440310243918,0.0690022741521524,0.64584247435876,1.8184048728062,0.826804878959969,11.3377530375619,0.510036766167445,0.0754031320762053,1.12261061414134,0.671078964694216,13.6617156135614,0.132529157572648,"lineage4","dr_mutations_pyrazinamide","CYS",0,"ERR2510863","ERR2510863","lineage4.9","it","Italy","pnca_p.tyr103cys","A","-","TYR","YA103","pnca_complex.pdb"
|
|
"Y103C","L2","PZA","Y","Y103",103,"C",0,"MDR","DM","hydrophobic","hydrophobic","neutral","neutral","polar","non-polar",5.416,-0.48,0.606,1.02924,-0.498,1.43,68,80,-1.175,9,9,138,0.524714828897338,"loop",-0.1,3.94,0.0007187005893344,3.23621052631579,3.23621068095208,3.23583471755484,2.2626260572101,42,4,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-2,2,0,0,-2,0,-0.121580547112462,0.51530612244898,0.0374871611827009,-0.0849104859335038,0.803370786516854,0.715789473684211,-0.967874794069193,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.221,-1.152,"9:9","150/150","Y:K",1.17440310243918,0.0690022741521524,0.64584247435876,1.8184048728062,0.826804878959969,11.3377530375619,0.510036766167445,0.0754031320762053,1.12261061414134,0.671078964694216,13.6617156135614,0.132529157572648,"lineage2","dr_mutations_pyrazinamide","CYS",0,"MDR_16514","SRR6824569","lineage2.2.1","cn","China: Nanyang City, Henan Province","pnca_p.tyr103cys","A","-","TYR","YA103","pnca_complex.pdb"
|
|
"Y103C","L4","PZA","Y","Y103",103,"C",NA,"MDR","DM","hydrophobic","hydrophobic","neutral","neutral","polar","non-polar",5.416,-0.48,0.606,1.02924,-0.498,1.43,68,80,-1.175,9,9,138,0.524714828897338,"loop",-0.1,3.94,0.0007187005893344,3.23621052631579,3.23621068095208,3.23583471755484,2.2626260572101,42,4,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-2,2,0,0,-2,0,-0.121580547112462,0.51530612244898,0.0374871611827009,-0.0849104859335038,0.803370786516854,0.715789473684211,-0.967874794069193,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.221,-1.152,"9:9","150/150","Y:K",1.17440310243918,0.0690022741521524,0.64584247435876,1.8184048728062,0.826804878959969,11.3377530375619,0.510036766167445,0.0754031320762053,1.12261061414134,0.671078964694216,13.6617156135614,0.132529157572648,"lineage4","dr_mutations_pyrazinamide","CYS",0,"ERR2516640","ERR2516640","lineage4.3.4.2","nl","Netherlands","pnca_p.tyr103cys","A","-","TYR","YA103","pnca_complex.pdb"
|
|
"Y103C","L2","PZA","Y","Y103",103,"C",NA,"MDR","DM","hydrophobic","hydrophobic","neutral","neutral","polar","non-polar",5.416,-0.48,0.606,1.02924,-0.498,1.43,68,80,-1.175,9,9,138,0.524714828897338,"loop",-0.1,3.94,0.0007187005893344,3.23621052631579,3.23621068095208,3.23583471755484,2.2626260572101,42,4,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-2,2,0,0,-2,0,-0.121580547112462,0.51530612244898,0.0374871611827009,-0.0849104859335038,0.803370786516854,0.715789473684211,-0.967874794069193,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.221,-1.152,"9:9","150/150","Y:K",1.17440310243918,0.0690022741521524,0.64584247435876,1.8184048728062,0.826804878959969,11.3377530375619,0.510036766167445,0.0754031320762053,1.12261061414134,0.671078964694216,13.6617156135614,0.132529157572648,"lineage2","dr_mutations_pyrazinamide","CYS",0,"SRS796966","SRR1723453","lineage2.2.1","cn","China:Henan","pnca_p.tyr103cys","A","-","TYR","YA103","pnca_complex.pdb"
|
|
"Y103D","L2","PZA","Y","Y103",103,"D",1,"MDR","OM","hydrophobic","hydrophilic","neutral","acidic","polar","neg",5.416,0.851,1.176,1.18458,-0.578,1.51,88,91,-1.175,9,9,138,0.524714828897338,"loop",-0.1,3.94,0.0021561017680034,142.334468085106,142.334276537658,142.74783870505,128.720903887203,34,-24,0,0,-24,0,0,0,0,0,0,0,0,0,0,0,0,2,0,-2,4,-2,0,-2,-2,0.381614349775785,1,0.0431449821167112,-0.0985507246376812,0.848314606741573,0.926315789473684,-0.967874794069193,"Stabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.221,-1.152,"9:9","150/150","Y:K",4.95817835126683,1.0743991920355e-06,1.01654133277845,4.87749803317387,30.4620917601388,2537.05252258235,2.1533100827021,1.23916669217761e-21,20.9068702685848,23.5556923218963,5610.51758528632,7.80576752108032e-30,"lineage2","other_mutations_pyrazinamide","ASP",0,"15MT_1210","SRR5551225","lineage2.2.1.1","pg","","pnca_p.tyr103asp","A","-","TYR","YA103","pnca_complex.pdb"
|
|
"Y103D","L2","PZA","Y","Y103",103,"D",NA,"MDR","OM","hydrophobic","hydrophilic","neutral","acidic","polar","neg",5.416,0.851,1.176,1.18458,-0.578,1.51,88,91,-1.175,9,9,138,0.524714828897338,"loop",-0.1,3.94,0.0021561017680034,142.334468085106,142.334276537658,142.74783870505,128.720903887203,34,-24,0,0,-24,0,0,0,0,0,0,0,0,0,0,0,0,2,0,-2,4,-2,0,-2,-2,0.381614349775785,1,0.0431449821167112,-0.0985507246376812,0.848314606741573,0.926315789473684,-0.967874794069193,"Stabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.221,-1.152,"9:9","150/150","Y:K",4.95817835126683,1.0743991920355e-06,1.01654133277845,4.87749803317387,30.4620917601388,2537.05252258235,2.1533100827021,1.23916669217761e-21,20.9068702685848,23.5556923218963,5610.51758528632,7.80576752108032e-30,"lineage2","other_mutations_pyrazinamide","ASP",0,"SRR6079940","SRR6079940","lineage2.2.1.1","au","","pnca_p.tyr103asp","A","-","TYR","YA103","pnca_complex.pdb"
|
|
"Y103D","L2","PZA","Y","Y103",103,"D",1,"MDR","OM","hydrophobic","hydrophilic","neutral","acidic","polar","neg",5.416,0.851,1.176,1.18458,-0.578,1.51,88,91,-1.175,9,9,138,0.524714828897338,"loop",-0.1,3.94,0.0021561017680034,142.334468085106,142.334276537658,142.74783870505,128.720903887203,34,-24,0,0,-24,0,0,0,0,0,0,0,0,0,0,0,0,2,0,-2,4,-2,0,-2,-2,0.381614349775785,1,0.0431449821167112,-0.0985507246376812,0.848314606741573,0.926315789473684,-0.967874794069193,"Stabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.221,-1.152,"9:9","150/150","Y:K",4.95817835126683,1.0743991920355e-06,1.01654133277845,4.87749803317387,30.4620917601388,2537.05252258235,2.1533100827021,1.23916669217761e-21,20.9068702685848,23.5556923218963,5610.51758528632,7.80576752108032e-30,"lineage2","other_mutations_pyrazinamide","ASP",0,"13MT_2908","SRR5525980","lineage2.2.1.1","pg","","pnca_p.tyr103asp","A","-","TYR","YA103","pnca_complex.pdb"
|
|
"Y103D","L2","PZA","Y","Y103",103,"D",NA,"MDR","OM","hydrophobic","hydrophilic","neutral","acidic","polar","neg",5.416,0.851,1.176,1.18458,-0.578,1.51,88,91,-1.175,9,9,138,0.524714828897338,"loop",-0.1,3.94,0.0021561017680034,142.334468085106,142.334276537658,142.74783870505,128.720903887203,34,-24,0,0,-24,0,0,0,0,0,0,0,0,0,0,0,0,2,0,-2,4,-2,0,-2,-2,0.381614349775785,1,0.0431449821167112,-0.0985507246376812,0.848314606741573,0.926315789473684,-0.967874794069193,"Stabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.221,-1.152,"9:9","150/150","Y:K",4.95817835126683,1.0743991920355e-06,1.01654133277845,4.87749803317387,30.4620917601388,2537.05252258235,2.1533100827021,1.23916669217761e-21,20.9068702685848,23.5556923218963,5610.51758528632,7.80576752108032e-30,"lineage2","other_mutations_pyrazinamide","ASP",0,"ERR551554","ERR551554","lineage2.2.1","","Abkhazia,Georgia","pnca_p.tyr103asp","A","-","TYR","YA103","pnca_complex.pdb"
|
|
"Y103D","L2","PZA","Y","Y103",103,"D",1,"MDR","OM","hydrophobic","hydrophilic","neutral","acidic","polar","neg",5.416,0.851,1.176,1.18458,-0.578,1.51,88,91,-1.175,9,9,138,0.524714828897338,"loop",-0.1,3.94,0.0021561017680034,142.334468085106,142.334276537658,142.74783870505,128.720903887203,34,-24,0,0,-24,0,0,0,0,0,0,0,0,0,0,0,0,2,0,-2,4,-2,0,-2,-2,0.381614349775785,1,0.0431449821167112,-0.0985507246376812,0.848314606741573,0.926315789473684,-0.967874794069193,"Stabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.221,-1.152,"9:9","150/150","Y:K",4.95817835126683,1.0743991920355e-06,1.01654133277845,4.87749803317387,30.4620917601388,2537.05252258235,2.1533100827021,1.23916669217761e-21,20.9068702685848,23.5556923218963,5610.51758528632,7.80576752108032e-30,"lineage2","other_mutations_pyrazinamide","ASP",0,"14MT_17270","SRR5526788","lineage2.2.1.1","pg","","pnca_p.tyr103asp","A","-","TYR","YA103","pnca_complex.pdb"
|
|
"Y103D","L2","PZA","Y","Y103",103,"D",1,"MDR","OM","hydrophobic","hydrophilic","neutral","acidic","polar","neg",5.416,0.851,1.176,1.18458,-0.578,1.51,88,91,-1.175,9,9,138,0.524714828897338,"loop",-0.1,3.94,0.0021561017680034,142.334468085106,142.334276537658,142.74783870505,128.720903887203,34,-24,0,0,-24,0,0,0,0,0,0,0,0,0,0,0,0,2,0,-2,4,-2,0,-2,-2,0.381614349775785,1,0.0431449821167112,-0.0985507246376812,0.848314606741573,0.926315789473684,-0.967874794069193,"Stabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.221,-1.152,"9:9","150/150","Y:K",4.95817835126683,1.0743991920355e-06,1.01654133277845,4.87749803317387,30.4620917601388,2537.05252258235,2.1533100827021,1.23916669217761e-21,20.9068702685848,23.5556923218963,5610.51758528632,7.80576752108032e-30,"lineage2","other_mutations_pyrazinamide","ASP",0,"14MT_14657","SRR5526782","lineage2.2.1.1","pg","","pnca_p.tyr103asp","A","-","TYR","YA103","pnca_complex.pdb"
|
|
"Y103D","L2","PZA","Y","Y103",103,"D",NA,"MDR","OM","hydrophobic","hydrophilic","neutral","acidic","polar","neg",5.416,0.851,1.176,1.18458,-0.578,1.51,88,91,-1.175,9,9,138,0.524714828897338,"loop",-0.1,3.94,0.0021561017680034,142.334468085106,142.334276537658,142.74783870505,128.720903887203,34,-24,0,0,-24,0,0,0,0,0,0,0,0,0,0,0,0,2,0,-2,4,-2,0,-2,-2,0.381614349775785,1,0.0431449821167112,-0.0985507246376812,0.848314606741573,0.926315789473684,-0.967874794069193,"Stabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.221,-1.152,"9:9","150/150","Y:K",4.95817835126683,1.0743991920355e-06,1.01654133277845,4.87749803317387,30.4620917601388,2537.05252258235,2.1533100827021,1.23916669217761e-21,20.9068702685848,23.5556923218963,5610.51758528632,7.80576752108032e-30,"lineage2","other_mutations_pyrazinamide","ASP",0,"SRR6117325","SRR6117325","lineage2.2.1.1","au","","pnca_p.tyr103asp","A","-","TYR","YA103","pnca_complex.pdb"
|
|
"Y103D","L2","PZA","Y","Y103",103,"D",NA,"MDR","OM","hydrophobic","hydrophilic","neutral","acidic","polar","neg",5.416,0.851,1.176,1.18458,-0.578,1.51,88,91,-1.175,9,9,138,0.524714828897338,"loop",-0.1,3.94,0.0021561017680034,142.334468085106,142.334276537658,142.74783870505,128.720903887203,34,-24,0,0,-24,0,0,0,0,0,0,0,0,0,0,0,0,2,0,-2,4,-2,0,-2,-2,0.381614349775785,1,0.0431449821167112,-0.0985507246376812,0.848314606741573,0.926315789473684,-0.967874794069193,"Stabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.221,-1.152,"9:9","150/150","Y:K",4.95817835126683,1.0743991920355e-06,1.01654133277845,4.87749803317387,30.4620917601388,2537.05252258235,2.1533100827021,1.23916669217761e-21,20.9068702685848,23.5556923218963,5610.51758528632,7.80576752108032e-30,"lineage2","other_mutations_pyrazinamide","ASP",0,"SRR6079915","SRR6079915","lineage2.2.1.1","au","","pnca_p.tyr103asp","A","-","TYR","YA103","pnca_complex.pdb"
|
|
"Y103D","L2","PZA","Y","Y103",103,"D",1,"XDR","OM","hydrophobic","hydrophilic","neutral","acidic","polar","neg",5.416,0.851,1.176,1.18458,-0.578,1.51,88,91,-1.175,9,9,138,0.524714828897338,"loop",-0.1,3.94,0.0021561017680034,142.334468085106,142.334276537658,142.74783870505,128.720903887203,34,-24,0,0,-24,0,0,0,0,0,0,0,0,0,0,0,0,2,0,-2,4,-2,0,-2,-2,0.381614349775785,1,0.0431449821167112,-0.0985507246376812,0.848314606741573,0.926315789473684,-0.967874794069193,"Stabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.221,-1.152,"9:9","150/150","Y:K",4.95817835126683,1.0743991920355e-06,1.01654133277845,4.87749803317387,30.4620917601388,2537.05252258235,2.1533100827021,1.23916669217761e-21,20.9068702685848,23.5556923218963,5610.51758528632,7.80576752108032e-30,"lineage2","other_mutations_pyrazinamide","ASP",0,"14MT_20823","SRR5526844","lineage2.2.1.1","pg","","pnca_p.tyr103asp","A","-","TYR","YA103","pnca_complex.pdb"
|
|
"Y103D","L2","PZA","Y","Y103",103,"D",1,"MDR","OM","hydrophobic","hydrophilic","neutral","acidic","polar","neg",5.416,0.851,1.176,1.18458,-0.578,1.51,88,91,-1.175,9,9,138,0.524714828897338,"loop",-0.1,3.94,0.0021561017680034,142.334468085106,142.334276537658,142.74783870505,128.720903887203,34,-24,0,0,-24,0,0,0,0,0,0,0,0,0,0,0,0,2,0,-2,4,-2,0,-2,-2,0.381614349775785,1,0.0431449821167112,-0.0985507246376812,0.848314606741573,0.926315789473684,-0.967874794069193,"Stabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.221,-1.152,"9:9","150/150","Y:K",4.95817835126683,1.0743991920355e-06,1.01654133277845,4.87749803317387,30.4620917601388,2537.05252258235,2.1533100827021,1.23916669217761e-21,20.9068702685848,23.5556923218963,5610.51758528632,7.80576752108032e-30,"lineage2","other_mutations_pyrazinamide","ASP",0,"14MT_11623","SRR5525996","lineage2.2.1.1","pg","","pnca_p.tyr103asp","A","-","TYR","YA103","pnca_complex.pdb"
|
|
"Y103D","L2","PZA","Y","Y103",103,"D",1,"MDR","OM","hydrophobic","hydrophilic","neutral","acidic","polar","neg",5.416,0.851,1.176,1.18458,-0.578,1.51,88,91,-1.175,9,9,138,0.524714828897338,"loop",-0.1,3.94,0.0021561017680034,142.334468085106,142.334276537658,142.74783870505,128.720903887203,34,-24,0,0,-24,0,0,0,0,0,0,0,0,0,0,0,0,2,0,-2,4,-2,0,-2,-2,0.381614349775785,1,0.0431449821167112,-0.0985507246376812,0.848314606741573,0.926315789473684,-0.967874794069193,"Stabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.221,-1.152,"9:9","150/150","Y:K",4.95817835126683,1.0743991920355e-06,1.01654133277845,4.87749803317387,30.4620917601388,2537.05252258235,2.1533100827021,1.23916669217761e-21,20.9068702685848,23.5556923218963,5610.51758528632,7.80576752108032e-30,"lineage2","other_mutations_pyrazinamide","ASP",0,"14MT_9915","SRR5527201","lineage2.2.1.1","pg","","pnca_p.tyr103asp","A","-","TYR","YA103","pnca_complex.pdb"
|
|
"Y103D","L2","PZA","Y","Y103",103,"D",1,"MDR","OM","hydrophobic","hydrophilic","neutral","acidic","polar","neg",5.416,0.851,1.176,1.18458,-0.578,1.51,88,91,-1.175,9,9,138,0.524714828897338,"loop",-0.1,3.94,0.0021561017680034,142.334468085106,142.334276537658,142.74783870505,128.720903887203,34,-24,0,0,-24,0,0,0,0,0,0,0,0,0,0,0,0,2,0,-2,4,-2,0,-2,-2,0.381614349775785,1,0.0431449821167112,-0.0985507246376812,0.848314606741573,0.926315789473684,-0.967874794069193,"Stabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.221,-1.152,"9:9","150/150","Y:K",4.95817835126683,1.0743991920355e-06,1.01654133277845,4.87749803317387,30.4620917601388,2537.05252258235,2.1533100827021,1.23916669217761e-21,20.9068702685848,23.5556923218963,5610.51758528632,7.80576752108032e-30,"lineage2","other_mutations_pyrazinamide","ASP",0,"14MT_6104","SRR5526904","lineage2.2.1.1","pg","","pnca_p.tyr103asp","A","-","TYR","YA103","pnca_complex.pdb"
|
|
"Y103D","L2","PZA","Y","Y103",103,"D",1,"XDR","OM","hydrophobic","hydrophilic","neutral","acidic","polar","neg",5.416,0.851,1.176,1.18458,-0.578,1.51,88,91,-1.175,9,9,138,0.524714828897338,"loop",-0.1,3.94,0.0021561017680034,142.334468085106,142.334276537658,142.74783870505,128.720903887203,34,-24,0,0,-24,0,0,0,0,0,0,0,0,0,0,0,0,2,0,-2,4,-2,0,-2,-2,0.381614349775785,1,0.0431449821167112,-0.0985507246376812,0.848314606741573,0.926315789473684,-0.967874794069193,"Stabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.221,-1.152,"9:9","150/150","Y:K",4.95817835126683,1.0743991920355e-06,1.01654133277845,4.87749803317387,30.4620917601388,2537.05252258235,2.1533100827021,1.23916669217761e-21,20.9068702685848,23.5556923218963,5610.51758528632,7.80576752108032e-30,"lineage2","other_mutations_pyrazinamide","ASP",0,"14MT_6107","SRR5526915","lineage2.2.1.1","pg","","pnca_p.tyr103asp","A","-","TYR","YA103","pnca_complex.pdb"
|
|
"Y103D","L2","PZA","Y","Y103",103,"D",1,"MDR","OM","hydrophobic","hydrophilic","neutral","acidic","polar","neg",5.416,0.851,1.176,1.18458,-0.578,1.51,88,91,-1.175,9,9,138,0.524714828897338,"loop",-0.1,3.94,0.0021561017680034,142.334468085106,142.334276537658,142.74783870505,128.720903887203,34,-24,0,0,-24,0,0,0,0,0,0,0,0,0,0,0,0,2,0,-2,4,-2,0,-2,-2,0.381614349775785,1,0.0431449821167112,-0.0985507246376812,0.848314606741573,0.926315789473684,-0.967874794069193,"Stabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.221,-1.152,"9:9","150/150","Y:K",4.95817835126683,1.0743991920355e-06,1.01654133277845,4.87749803317387,30.4620917601388,2537.05252258235,2.1533100827021,1.23916669217761e-21,20.9068702685848,23.5556923218963,5610.51758528632,7.80576752108032e-30,"lineage2","other_mutations_pyrazinamide","ASP",0,"14MT_9929","SRR5533131","lineage2.2.1.1","pg","","pnca_p.tyr103asp","A","-","TYR","YA103","pnca_complex.pdb"
|
|
"Y103D","L2","PZA","Y","Y103",103,"D",1,"MDR","OM","hydrophobic","hydrophilic","neutral","acidic","polar","neg",5.416,0.851,1.176,1.18458,-0.578,1.51,88,91,-1.175,9,9,138,0.524714828897338,"loop",-0.1,3.94,0.0021561017680034,142.334468085106,142.334276537658,142.74783870505,128.720903887203,34,-24,0,0,-24,0,0,0,0,0,0,0,0,0,0,0,0,2,0,-2,4,-2,0,-2,-2,0.381614349775785,1,0.0431449821167112,-0.0985507246376812,0.848314606741573,0.926315789473684,-0.967874794069193,"Stabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.221,-1.152,"9:9","150/150","Y:K",4.95817835126683,1.0743991920355e-06,1.01654133277845,4.87749803317387,30.4620917601388,2537.05252258235,2.1533100827021,1.23916669217761e-21,20.9068702685848,23.5556923218963,5610.51758528632,7.80576752108032e-30,"lineage2","other_mutations_pyrazinamide","ASP",0,"15MT_1217","SRR5550936","lineage2.2.1.1","pg","","pnca_p.tyr103asp","A","-","TYR","YA103","pnca_complex.pdb"
|
|
"Y103D","L2","PZA","Y","Y103",103,"D",1,"MDR","OM","hydrophobic","hydrophilic","neutral","acidic","polar","neg",5.416,0.851,1.176,1.18458,-0.578,1.51,88,91,-1.175,9,9,138,0.524714828897338,"loop",-0.1,3.94,0.0021561017680034,142.334468085106,142.334276537658,142.74783870505,128.720903887203,34,-24,0,0,-24,0,0,0,0,0,0,0,0,0,0,0,0,2,0,-2,4,-2,0,-2,-2,0.381614349775785,1,0.0431449821167112,-0.0985507246376812,0.848314606741573,0.926315789473684,-0.967874794069193,"Stabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.221,-1.152,"9:9","150/150","Y:K",4.95817835126683,1.0743991920355e-06,1.01654133277845,4.87749803317387,30.4620917601388,2537.05252258235,2.1533100827021,1.23916669217761e-21,20.9068702685848,23.5556923218963,5610.51758528632,7.80576752108032e-30,"lineage2","other_mutations_pyrazinamide","ASP",0,"15MT_1238","SRR5551477","lineage2.2.1.1","pg","","pnca_p.tyr103asp","A","-","TYR","YA103","pnca_complex.pdb"
|
|
"Y103D","L2","PZA","Y","Y103",103,"D",1,"MDR","OM","hydrophobic","hydrophilic","neutral","acidic","polar","neg",5.416,0.851,1.176,1.18458,-0.578,1.51,88,91,-1.175,9,9,138,0.524714828897338,"loop",-0.1,3.94,0.0021561017680034,142.334468085106,142.334276537658,142.74783870505,128.720903887203,34,-24,0,0,-24,0,0,0,0,0,0,0,0,0,0,0,0,2,0,-2,4,-2,0,-2,-2,0.381614349775785,1,0.0431449821167112,-0.0985507246376812,0.848314606741573,0.926315789473684,-0.967874794069193,"Stabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.221,-1.152,"9:9","150/150","Y:K",4.95817835126683,1.0743991920355e-06,1.01654133277845,4.87749803317387,30.4620917601388,2537.05252258235,2.1533100827021,1.23916669217761e-21,20.9068702685848,23.5556923218963,5610.51758528632,7.80576752108032e-30,"lineage2","other_mutations_pyrazinamide","ASP",0,"14MT_13365","SRR5526158","lineage2.2.1.1","pg","","pnca_p.tyr103asp","A","-","TYR","YA103","pnca_complex.pdb"
|
|
"Y103D","L2","PZA","Y","Y103",103,"D",1,"MDR","OM","hydrophobic","hydrophilic","neutral","acidic","polar","neg",5.416,0.851,1.176,1.18458,-0.578,1.51,88,91,-1.175,9,9,138,0.524714828897338,"loop",-0.1,3.94,0.0021561017680034,142.334468085106,142.334276537658,142.74783870505,128.720903887203,34,-24,0,0,-24,0,0,0,0,0,0,0,0,0,0,0,0,2,0,-2,4,-2,0,-2,-2,0.381614349775785,1,0.0431449821167112,-0.0985507246376812,0.848314606741573,0.926315789473684,-0.967874794069193,"Stabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.221,-1.152,"9:9","150/150","Y:K",4.95817835126683,1.0743991920355e-06,1.01654133277845,4.87749803317387,30.4620917601388,2537.05252258235,2.1533100827021,1.23916669217761e-21,20.9068702685848,23.5556923218963,5610.51758528632,7.80576752108032e-30,"lineage2","other_mutations_pyrazinamide","ASP",0,"15MT_3222","SRR5551664","lineage2.2.1.1","pg","","pnca_p.tyr103asp","A","-","TYR","YA103","pnca_complex.pdb"
|
|
"Y103D","L2","PZA","Y","Y103",103,"D",1,"MDR","OM","hydrophobic","hydrophilic","neutral","acidic","polar","neg",5.416,0.851,1.176,1.18458,-0.578,1.51,88,91,-1.175,9,9,138,0.524714828897338,"loop",-0.1,3.94,0.0021561017680034,142.334468085106,142.334276537658,142.74783870505,128.720903887203,34,-24,0,0,-24,0,0,0,0,0,0,0,0,0,0,0,0,2,0,-2,4,-2,0,-2,-2,0.381614349775785,1,0.0431449821167112,-0.0985507246376812,0.848314606741573,0.926315789473684,-0.967874794069193,"Stabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.221,-1.152,"9:9","150/150","Y:K",4.95817835126683,1.0743991920355e-06,1.01654133277845,4.87749803317387,30.4620917601388,2537.05252258235,2.1533100827021,1.23916669217761e-21,20.9068702685848,23.5556923218963,5610.51758528632,7.80576752108032e-30,"lineage2","other_mutations_pyrazinamide","ASP",0,"14MT_13366","SRR5526332","lineage2.2.1.1","pg","","pnca_p.tyr103asp","A","-","TYR","YA103","pnca_complex.pdb"
|
|
"Y103D","L2","PZA","Y","Y103",103,"D",1,"MDR","OM","hydrophobic","hydrophilic","neutral","acidic","polar","neg",5.416,0.851,1.176,1.18458,-0.578,1.51,88,91,-1.175,9,9,138,0.524714828897338,"loop",-0.1,3.94,0.0021561017680034,142.334468085106,142.334276537658,142.74783870505,128.720903887203,34,-24,0,0,-24,0,0,0,0,0,0,0,0,0,0,0,0,2,0,-2,4,-2,0,-2,-2,0.381614349775785,1,0.0431449821167112,-0.0985507246376812,0.848314606741573,0.926315789473684,-0.967874794069193,"Stabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.221,-1.152,"9:9","150/150","Y:K",4.95817835126683,1.0743991920355e-06,1.01654133277845,4.87749803317387,30.4620917601388,2537.05252258235,2.1533100827021,1.23916669217761e-21,20.9068702685848,23.5556923218963,5610.51758528632,7.80576752108032e-30,"lineage2","other_mutations_pyrazinamide","ASP",0,"14MT_9913","SRR5527199","lineage2.2.1.1","pg","","pnca_p.tyr103asp","A","-","TYR","YA103","pnca_complex.pdb"
|
|
"Y103D","L2","PZA","Y","Y103",103,"D",1,"XDR","OM","hydrophobic","hydrophilic","neutral","acidic","polar","neg",5.416,0.851,1.176,1.18458,-0.578,1.51,88,91,-1.175,9,9,138,0.524714828897338,"loop",-0.1,3.94,0.0021561017680034,142.334468085106,142.334276537658,142.74783870505,128.720903887203,34,-24,0,0,-24,0,0,0,0,0,0,0,0,0,0,0,0,2,0,-2,4,-2,0,-2,-2,0.381614349775785,1,0.0431449821167112,-0.0985507246376812,0.848314606741573,0.926315789473684,-0.967874794069193,"Stabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.221,-1.152,"9:9","150/150","Y:K",4.95817835126683,1.0743991920355e-06,1.01654133277845,4.87749803317387,30.4620917601388,2537.05252258235,2.1533100827021,1.23916669217761e-21,20.9068702685848,23.5556923218963,5610.51758528632,7.80576752108032e-30,"lineage2","other_mutations_pyrazinamide","ASP",0,"14MT_9917","SRR5527202","lineage2.2.1.1","pg","","pnca_p.tyr103asp","A","-","TYR","YA103","pnca_complex.pdb"
|
|
"Y103D","L2","PZA","Y","Y103",103,"D",NA,"MDR","OM","hydrophobic","hydrophilic","neutral","acidic","polar","neg",5.416,0.851,1.176,1.18458,-0.578,1.51,88,91,-1.175,9,9,138,0.524714828897338,"loop",-0.1,3.94,0.0021561017680034,142.334468085106,142.334276537658,142.74783870505,128.720903887203,34,-24,0,0,-24,0,0,0,0,0,0,0,0,0,0,0,0,2,0,-2,4,-2,0,-2,-2,0.381614349775785,1,0.0431449821167112,-0.0985507246376812,0.848314606741573,0.926315789473684,-0.967874794069193,"Stabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.221,-1.152,"9:9","150/150","Y:K",4.95817835126683,1.0743991920355e-06,1.01654133277845,4.87749803317387,30.4620917601388,2537.05252258235,2.1533100827021,1.23916669217761e-21,20.9068702685848,23.5556923218963,5610.51758528632,7.80576752108032e-30,"lineage2","other_mutations_pyrazinamide","ASP",0,"SRR6117329","SRR6117329","lineage2.2.1.1","au","","pnca_p.tyr103asp","A","-","TYR","YA103","pnca_complex.pdb"
|
|
"Y103D","L2","PZA","Y","Y103",103,"D",1,"Pre-XDR","OM","hydrophobic","hydrophilic","neutral","acidic","polar","neg",5.416,0.851,1.176,1.18458,-0.578,1.51,88,91,-1.175,9,9,138,0.524714828897338,"loop",-0.1,3.94,0.0021561017680034,142.334468085106,142.334276537658,142.74783870505,128.720903887203,34,-24,0,0,-24,0,0,0,0,0,0,0,0,0,0,0,0,2,0,-2,4,-2,0,-2,-2,0.381614349775785,1,0.0431449821167112,-0.0985507246376812,0.848314606741573,0.926315789473684,-0.967874794069193,"Stabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.221,-1.152,"9:9","150/150","Y:K",4.95817835126683,1.0743991920355e-06,1.01654133277845,4.87749803317387,30.4620917601388,2537.05252258235,2.1533100827021,1.23916669217761e-21,20.9068702685848,23.5556923218963,5610.51758528632,7.80576752108032e-30,"lineage2","other_mutations_pyrazinamide","ASP",0,"14MT_13384","SRR5526639","lineage2.2.1.1","pg","","pnca_p.tyr103asp","A","-","TYR","YA103","pnca_complex.pdb"
|
|
"Y103D","L4","PZA","Y","Y103",103,"D",NA,"Pre-MDR","OM","hydrophobic","hydrophilic","neutral","acidic","polar","neg",5.416,0.851,1.176,1.18458,-0.578,1.51,88,91,-1.175,9,9,138,0.524714828897338,"loop",-0.1,3.94,0.0021561017680034,142.334468085106,142.334276537658,142.74783870505,128.720903887203,34,-24,0,0,-24,0,0,0,0,0,0,0,0,0,0,0,0,2,0,-2,4,-2,0,-2,-2,0.381614349775785,1,0.0431449821167112,-0.0985507246376812,0.848314606741573,0.926315789473684,-0.967874794069193,"Stabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.221,-1.152,"9:9","150/150","Y:K",4.95817835126683,1.0743991920355e-06,1.01654133277845,4.87749803317387,30.4620917601388,2537.05252258235,2.1533100827021,1.23916669217761e-21,20.9068702685848,23.5556923218963,5610.51758528632,7.80576752108032e-30,"lineage4","other_mutations_pyrazinamide","ASP",0,"ERR1193662","ERR1193662","lineage4.3.3","so","Somalia","pnca_p.tyr103asp","A","-","TYR","YA103","pnca_complex.pdb"
|
|
"Y103D","L2","PZA","Y","Y103",103,"D",1,"XDR","OM","hydrophobic","hydrophilic","neutral","acidic","polar","neg",5.416,0.851,1.176,1.18458,-0.578,1.51,88,91,-1.175,9,9,138,0.524714828897338,"loop",-0.1,3.94,0.0021561017680034,142.334468085106,142.334276537658,142.74783870505,128.720903887203,34,-24,0,0,-24,0,0,0,0,0,0,0,0,0,0,0,0,2,0,-2,4,-2,0,-2,-2,0.381614349775785,1,0.0431449821167112,-0.0985507246376812,0.848314606741573,0.926315789473684,-0.967874794069193,"Stabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.221,-1.152,"9:9","150/150","Y:K",4.95817835126683,1.0743991920355e-06,1.01654133277845,4.87749803317387,30.4620917601388,2537.05252258235,2.1533100827021,1.23916669217761e-21,20.9068702685848,23.5556923218963,5610.51758528632,7.80576752108032e-30,"lineage2","other_mutations_pyrazinamide","ASP",0,"14MT_14644","SRR5526642","lineage2.2.1.1","pg","","pnca_p.tyr103asp","A","-","TYR","YA103","pnca_complex.pdb"
|
|
"Y103D","L2","PZA","Y","Y103",103,"D",1,"MDR","OM","hydrophobic","hydrophilic","neutral","acidic","polar","neg",5.416,0.851,1.176,1.18458,-0.578,1.51,88,91,-1.175,9,9,138,0.524714828897338,"loop",-0.1,3.94,0.0021561017680034,142.334468085106,142.334276537658,142.74783870505,128.720903887203,34,-24,0,0,-24,0,0,0,0,0,0,0,0,0,0,0,0,2,0,-2,4,-2,0,-2,-2,0.381614349775785,1,0.0431449821167112,-0.0985507246376812,0.848314606741573,0.926315789473684,-0.967874794069193,"Stabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.221,-1.152,"9:9","150/150","Y:K",4.95817835126683,1.0743991920355e-06,1.01654133277845,4.87749803317387,30.4620917601388,2537.05252258235,2.1533100827021,1.23916669217761e-21,20.9068702685848,23.5556923218963,5610.51758528632,7.80576752108032e-30,"lineage2","other_mutations_pyrazinamide","ASP",0,"14MT_11613","SRR5525985","lineage2.2.1.1","pg","","pnca_p.tyr103asp","A","-","TYR","YA103","pnca_complex.pdb"
|
|
"Y103D","L2","PZA","Y","Y103",103,"D",NA,"MDR","OM","hydrophobic","hydrophilic","neutral","acidic","polar","neg",5.416,0.851,1.176,1.18458,-0.578,1.51,88,91,-1.175,9,9,138,0.524714828897338,"loop",-0.1,3.94,0.0021561017680034,142.334468085106,142.334276537658,142.74783870505,128.720903887203,34,-24,0,0,-24,0,0,0,0,0,0,0,0,0,0,0,0,2,0,-2,4,-2,0,-2,-2,0.381614349775785,1,0.0431449821167112,-0.0985507246376812,0.848314606741573,0.926315789473684,-0.967874794069193,"Stabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.221,-1.152,"9:9","150/150","Y:K",4.95817835126683,1.0743991920355e-06,1.01654133277845,4.87749803317387,30.4620917601388,2537.05252258235,2.1533100827021,1.23916669217761e-21,20.9068702685848,23.5556923218963,5610.51758528632,7.80576752108032e-30,"lineage2","other_mutations_pyrazinamide","ASP",0,"SRR6117348","SRR6117348","lineage2.2.1.1","au","","pnca_p.tyr103asp","A","-","TYR","YA103","pnca_complex.pdb"
|
|
"Y103D","L2","PZA","Y","Y103",103,"D",NA,"MDR","OM","hydrophobic","hydrophilic","neutral","acidic","polar","neg",5.416,0.851,1.176,1.18458,-0.578,1.51,88,91,-1.175,9,9,138,0.524714828897338,"loop",-0.1,3.94,0.0021561017680034,142.334468085106,142.334276537658,142.74783870505,128.720903887203,34,-24,0,0,-24,0,0,0,0,0,0,0,0,0,0,0,0,2,0,-2,4,-2,0,-2,-2,0.381614349775785,1,0.0431449821167112,-0.0985507246376812,0.848314606741573,0.926315789473684,-0.967874794069193,"Stabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.221,-1.152,"9:9","150/150","Y:K",4.95817835126683,1.0743991920355e-06,1.01654133277845,4.87749803317387,30.4620917601388,2537.05252258235,2.1533100827021,1.23916669217761e-21,20.9068702685848,23.5556923218963,5610.51758528632,7.80576752108032e-30,"lineage2","other_mutations_pyrazinamide","ASP",0,"SRR6079931","SRR6079931","lineage2.2.1.1","au","","pnca_p.tyr103asp","A","-","TYR","YA103","pnca_complex.pdb"
|
|
"Y103D","L2","PZA","Y","Y103",103,"D",1,"MDR","OM","hydrophobic","hydrophilic","neutral","acidic","polar","neg",5.416,0.851,1.176,1.18458,-0.578,1.51,88,91,-1.175,9,9,138,0.524714828897338,"loop",-0.1,3.94,0.0021561017680034,142.334468085106,142.334276537658,142.74783870505,128.720903887203,34,-24,0,0,-24,0,0,0,0,0,0,0,0,0,0,0,0,2,0,-2,4,-2,0,-2,-2,0.381614349775785,1,0.0431449821167112,-0.0985507246376812,0.848314606741573,0.926315789473684,-0.967874794069193,"Stabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.221,-1.152,"9:9","150/150","Y:K",4.95817835126683,1.0743991920355e-06,1.01654133277845,4.87749803317387,30.4620917601388,2537.05252258235,2.1533100827021,1.23916669217761e-21,20.9068702685848,23.5556923218963,5610.51758528632,7.80576752108032e-30,"lineage2","other_mutations_pyrazinamide","ASP",0,"14MT_9928","SRR5533130","lineage2.2.1.1","pg","","pnca_p.tyr103asp","A","-","TYR","YA103","pnca_complex.pdb"
|
|
"Y103D","L2","PZA","Y","Y103",103,"D",1,"MDR","OM","hydrophobic","hydrophilic","neutral","acidic","polar","neg",5.416,0.851,1.176,1.18458,-0.578,1.51,88,91,-1.175,9,9,138,0.524714828897338,"loop",-0.1,3.94,0.0021561017680034,142.334468085106,142.334276537658,142.74783870505,128.720903887203,34,-24,0,0,-24,0,0,0,0,0,0,0,0,0,0,0,0,2,0,-2,4,-2,0,-2,-2,0.381614349775785,1,0.0431449821167112,-0.0985507246376812,0.848314606741573,0.926315789473684,-0.967874794069193,"Stabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.221,-1.152,"9:9","150/150","Y:K",4.95817835126683,1.0743991920355e-06,1.01654133277845,4.87749803317387,30.4620917601388,2537.05252258235,2.1533100827021,1.23916669217761e-21,20.9068702685848,23.5556923218963,5610.51758528632,7.80576752108032e-30,"lineage2","other_mutations_pyrazinamide","ASP",0,"14MT_9963","SRR5533153","lineage2.2.1.1","pg","","pnca_p.tyr103asp","A","-","TYR","YA103","pnca_complex.pdb"
|
|
"Y103D","L2","PZA","Y","Y103",103,"D",1,"Pre-XDR","OM","hydrophobic","hydrophilic","neutral","acidic","polar","neg",5.416,0.851,1.176,1.18458,-0.578,1.51,88,91,-1.175,9,9,138,0.524714828897338,"loop",-0.1,3.94,0.0021561017680034,142.334468085106,142.334276537658,142.74783870505,128.720903887203,34,-24,0,0,-24,0,0,0,0,0,0,0,0,0,0,0,0,2,0,-2,4,-2,0,-2,-2,0.381614349775785,1,0.0431449821167112,-0.0985507246376812,0.848314606741573,0.926315789473684,-0.967874794069193,"Stabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.221,-1.152,"9:9","150/150","Y:K",4.95817835126683,1.0743991920355e-06,1.01654133277845,4.87749803317387,30.4620917601388,2537.05252258235,2.1533100827021,1.23916669217761e-21,20.9068702685848,23.5556923218963,5610.51758528632,7.80576752108032e-30,"lineage2","other_mutations_pyrazinamide","ASP",0,"14MT_9936","SRR5533152","lineage2.2.1.1","pg","","pnca_p.tyr103asp","A","-","TYR","YA103","pnca_complex.pdb"
|
|
"Y103D","L2","PZA","Y","Y103",103,"D",1,"XDR","OM","hydrophobic","hydrophilic","neutral","acidic","polar","neg",5.416,0.851,1.176,1.18458,-0.578,1.51,88,91,-1.175,9,9,138,0.524714828897338,"loop",-0.1,3.94,0.0021561017680034,142.334468085106,142.334276537658,142.74783870505,128.720903887203,34,-24,0,0,-24,0,0,0,0,0,0,0,0,0,0,0,0,2,0,-2,4,-2,0,-2,-2,0.381614349775785,1,0.0431449821167112,-0.0985507246376812,0.848314606741573,0.926315789473684,-0.967874794069193,"Stabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.221,-1.152,"9:9","150/150","Y:K",4.95817835126683,1.0743991920355e-06,1.01654133277845,4.87749803317387,30.4620917601388,2537.05252258235,2.1533100827021,1.23916669217761e-21,20.9068702685848,23.5556923218963,5610.51758528632,7.80576752108032e-30,"lineage2","other_mutations_pyrazinamide","ASP",0,"2080M-sc-2012-02-21T11:38:33Z-1364874,ERR144636","ERR144636","lineage2.2.1","ru","Russia,Samara","pnca_p.tyr103asp","A","-","TYR","YA103","pnca_complex.pdb"
|
|
"Y103D","L2","PZA","Y","Y103",103,"D",1,"MDR","OM","hydrophobic","hydrophilic","neutral","acidic","polar","neg",5.416,0.851,1.176,1.18458,-0.578,1.51,88,91,-1.175,9,9,138,0.524714828897338,"loop",-0.1,3.94,0.0021561017680034,142.334468085106,142.334276537658,142.74783870505,128.720903887203,34,-24,0,0,-24,0,0,0,0,0,0,0,0,0,0,0,0,2,0,-2,4,-2,0,-2,-2,0.381614349775785,1,0.0431449821167112,-0.0985507246376812,0.848314606741573,0.926315789473684,-0.967874794069193,"Stabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.221,-1.152,"9:9","150/150","Y:K",4.95817835126683,1.0743991920355e-06,1.01654133277845,4.87749803317387,30.4620917601388,2537.05252258235,2.1533100827021,1.23916669217761e-21,20.9068702685848,23.5556923218963,5610.51758528632,7.80576752108032e-30,"lineage2","other_mutations_pyrazinamide","ASP",0,"14MT_9902","SRR5527179","lineage2.2.1.1","pg","","pnca_p.tyr103asp","A","-","TYR","YA103","pnca_complex.pdb"
|
|
"Y103D","L2","PZA","Y","Y103",103,"D",1,"Pre-XDR","OM","hydrophobic","hydrophilic","neutral","acidic","polar","neg",5.416,0.851,1.176,1.18458,-0.578,1.51,88,91,-1.175,9,9,138,0.524714828897338,"loop",-0.1,3.94,0.0021561017680034,142.334468085106,142.334276537658,142.74783870505,128.720903887203,34,-24,0,0,-24,0,0,0,0,0,0,0,0,0,0,0,0,2,0,-2,4,-2,0,-2,-2,0.381614349775785,1,0.0431449821167112,-0.0985507246376812,0.848314606741573,0.926315789473684,-0.967874794069193,"Stabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.221,-1.152,"9:9","150/150","Y:K",4.95817835126683,1.0743991920355e-06,1.01654133277845,4.87749803317387,30.4620917601388,2537.05252258235,2.1533100827021,1.23916669217761e-21,20.9068702685848,23.5556923218963,5610.51758528632,7.80576752108032e-30,"lineage2","other_mutations_pyrazinamide","ASP",0,"14MT_9927","SRR5533129","lineage2.2.1.1","pg","","pnca_p.tyr103asp","A","-","TYR","YA103","pnca_complex.pdb"
|
|
"Y103D","L2","PZA","Y","Y103",103,"D",1,"Pre-XDR","OM","hydrophobic","hydrophilic","neutral","acidic","polar","neg",5.416,0.851,1.176,1.18458,-0.578,1.51,88,91,-1.175,9,9,138,0.524714828897338,"loop",-0.1,3.94,0.0021561017680034,142.334468085106,142.334276537658,142.74783870505,128.720903887203,34,-24,0,0,-24,0,0,0,0,0,0,0,0,0,0,0,0,2,0,-2,4,-2,0,-2,-2,0.381614349775785,1,0.0431449821167112,-0.0985507246376812,0.848314606741573,0.926315789473684,-0.967874794069193,"Stabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.221,-1.152,"9:9","150/150","Y:K",4.95817835126683,1.0743991920355e-06,1.01654133277845,4.87749803317387,30.4620917601388,2537.05252258235,2.1533100827021,1.23916669217761e-21,20.9068702685848,23.5556923218963,5610.51758528632,7.80576752108032e-30,"lineage2","other_mutations_pyrazinamide","ASP",0,"14MT_961","SRR5527176","lineage2.2.1.1","pg","","pnca_p.tyr103asp","A","-","TYR","YA103","pnca_complex.pdb"
|
|
"Y103D","L2","PZA","Y","Y103",103,"D",1,"Pre-XDR","OM","hydrophobic","hydrophilic","neutral","acidic","polar","neg",5.416,0.851,1.176,1.18458,-0.578,1.51,88,91,-1.175,9,9,138,0.524714828897338,"loop",-0.1,3.94,0.0021561017680034,142.334468085106,142.334276537658,142.74783870505,128.720903887203,34,-24,0,0,-24,0,0,0,0,0,0,0,0,0,0,0,0,2,0,-2,4,-2,0,-2,-2,0.381614349775785,1,0.0431449821167112,-0.0985507246376812,0.848314606741573,0.926315789473684,-0.967874794069193,"Stabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.221,-1.152,"9:9","150/150","Y:K",4.95817835126683,1.0743991920355e-06,1.01654133277845,4.87749803317387,30.4620917601388,2537.05252258235,2.1533100827021,1.23916669217761e-21,20.9068702685848,23.5556923218963,5610.51758528632,7.80576752108032e-30,"lineage2","other_mutations_pyrazinamide","ASP",0,"13MT_2933","SRR5525981","lineage2.2.1.1","pg","","pnca_p.tyr103asp","A","-","TYR","YA103","pnca_complex.pdb"
|
|
"Y103D","L2","PZA","Y","Y103",103,"D",1,"MDR","OM","hydrophobic","hydrophilic","neutral","acidic","polar","neg",5.416,0.851,1.176,1.18458,-0.578,1.51,88,91,-1.175,9,9,138,0.524714828897338,"loop",-0.1,3.94,0.0021561017680034,142.334468085106,142.334276537658,142.74783870505,128.720903887203,34,-24,0,0,-24,0,0,0,0,0,0,0,0,0,0,0,0,2,0,-2,4,-2,0,-2,-2,0.381614349775785,1,0.0431449821167112,-0.0985507246376812,0.848314606741573,0.926315789473684,-0.967874794069193,"Stabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.221,-1.152,"9:9","150/150","Y:K",4.95817835126683,1.0743991920355e-06,1.01654133277845,4.87749803317387,30.4620917601388,2537.05252258235,2.1533100827021,1.23916669217761e-21,20.9068702685848,23.5556923218963,5610.51758528632,7.80576752108032e-30,"lineage2","other_mutations_pyrazinamide","ASP",0,"15MT_3241","SRR5551666","lineage2.2.1.1","pg","","pnca_p.tyr103asp","A","-","TYR","YA103","pnca_complex.pdb"
|
|
"Y103D","L2","PZA","Y","Y103",103,"D",0,"Pre-XDR","OM","hydrophobic","hydrophilic","neutral","acidic","polar","neg",5.416,0.851,1.176,1.18458,-0.578,1.51,88,91,-1.175,9,9,138,0.524714828897338,"loop",-0.1,3.94,0.0021561017680034,142.334468085106,142.334276537658,142.74783870505,128.720903887203,34,-24,0,0,-24,0,0,0,0,0,0,0,0,0,0,0,0,2,0,-2,4,-2,0,-2,-2,0.381614349775785,1,0.0431449821167112,-0.0985507246376812,0.848314606741573,0.926315789473684,-0.967874794069193,"Stabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.221,-1.152,"9:9","150/150","Y:K",4.95817835126683,1.0743991920355e-06,1.01654133277845,4.87749803317387,30.4620917601388,2537.05252258235,2.1533100827021,1.23916669217761e-21,20.9068702685848,23.5556923218963,5610.51758528632,7.80576752108032e-30,"lineage2","other_mutations_pyrazinamide","ASP",0,"12MT_17228","SRR5527175","lineage2.2.1.1","pg","","pnca_p.tyr103asp","A","-","TYR","YA103","pnca_complex.pdb"
|
|
"Y103H","L2","PZA","Y","Y103",103,"H",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","neutral","basic","polar","pos",5.416,-0.046,0.779,0.909501,-0.683,1.21,81,91,-1.175,9,9,138,0.524714828897338,"loop",-0.1,3.94,0.0001437401178668,19.411022297013,511754.463552419,Inf,4.73122070382274,22,-22,0,0,-22,0,0,0,0,-2,0,-2,0,0,0,0,0,3,0,-1,4,0,0,0,0,-0.0116514690982776,0.662414965986395,0.0331260061626323,-0.116453537936914,0.679775280898876,0.852631578947368,-0.967874794069193,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.221,-1.152,"9:9","150/150","Y:K",13.1456002256202,0.924803768446986,139.27718332654,0.0943844491369405,0.0001628371344458,NA,1.28804840845689,0.0292235860951597,1.53426649183163,0.91081598550184,Inf,0.0296198560706035,"lineage2","dr_mutations_pyrazinamide","HIS",0,"SRR5709897,SAMN07236308","SRR5709897","lineage2.1","th","Thailand","pnca_p.tyr103his","A","-","TYR","YA103","pnca_complex.pdb"
|
|
"Y103H","L2","PZA","Y","Y103",103,"H",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","neutral","basic","polar","pos",5.416,-0.046,0.779,0.909501,-0.683,1.21,81,91,-1.175,9,9,138,0.524714828897338,"loop",-0.1,3.94,0.0001437401178668,19.411022297013,511754.463552419,Inf,4.73122070382274,22,-22,0,0,-22,0,0,0,0,-2,0,-2,0,0,0,0,0,3,0,-1,4,0,0,0,0,-0.0116514690982776,0.662414965986395,0.0331260061626323,-0.116453537936914,0.679775280898876,0.852631578947368,-0.967874794069193,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.221,-1.152,"9:9","150/150","Y:K",13.1456002256202,0.924803768446986,139.27718332654,0.0943844491369405,0.0001628371344458,NA,1.28804840845689,0.0292235860951597,1.53426649183163,0.91081598550184,Inf,0.0296198560706035,"lineage2","dr_mutations_pyrazinamide","HIS",0,"SRR5709898,SAMN07236309","SRR5709898","lineage2.1","th","Thailand","pnca_p.tyr103his","A","-","TYR","YA103","pnca_complex.pdb"
|
|
"Y103H","L2","PZA","Y","Y103",103,"H",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","neutral","basic","polar","pos",5.416,-0.046,0.779,0.909501,-0.683,1.21,81,91,-1.175,9,9,138,0.524714828897338,"loop",-0.1,3.94,0.0001437401178668,19.411022297013,511754.463552419,Inf,4.73122070382274,22,-22,0,0,-22,0,0,0,0,-2,0,-2,0,0,0,0,0,3,0,-1,4,0,0,0,0,-0.0116514690982776,0.662414965986395,0.0331260061626323,-0.116453537936914,0.679775280898876,0.852631578947368,-0.967874794069193,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.221,-1.152,"9:9","150/150","Y:K",13.1456002256202,0.924803768446986,139.27718332654,0.0943844491369405,0.0001628371344458,NA,1.28804840845689,0.0292235860951597,1.53426649183163,0.91081598550184,Inf,0.0296198560706035,"lineage2","dr_mutations_pyrazinamide","HIS",0,"SRR5710021","SRR5710021","lineage2.1","th","Thailand","pnca_p.tyr103his","A","-","TYR","YA103","pnca_complex.pdb"
|
|
"Y103H","L4","PZA","Y","Y103",103,"H",NA,"MDR","DM","hydrophobic","hydrophobic","neutral","basic","polar","pos",5.416,-0.046,0.779,0.909501,-0.683,1.21,81,91,-1.175,9,9,138,0.524714828897338,"loop",-0.1,3.94,0.0001437401178668,19.411022297013,511754.463552419,Inf,4.73122070382274,22,-22,0,0,-22,0,0,0,0,-2,0,-2,0,0,0,0,0,3,0,-1,4,0,0,0,0,-0.0116514690982776,0.662414965986395,0.0331260061626323,-0.116453537936914,0.679775280898876,0.852631578947368,-0.967874794069193,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.221,-1.152,"9:9","150/150","Y:K",13.1456002256202,0.924803768446986,139.27718332654,0.0943844491369405,0.0001628371344458,NA,1.28804840845689,0.0292235860951597,1.53426649183163,0.91081598550184,Inf,0.0296198560706035,"lineage4","dr_mutations_pyrazinamide","HIS",0,"SAMN02584645","SRR1166089_SRR1169051","lineage4.3.3","md","Moldova","pnca_p.tyr103his","A","-","TYR","YA103","pnca_complex.pdb"
|
|
"Y103H","L2","PZA","Y","Y103",103,"H",1,"XDR","DM","hydrophobic","hydrophobic","neutral","basic","polar","pos",5.416,-0.046,0.779,0.909501,-0.683,1.21,81,91,-1.175,9,9,138,0.524714828897338,"loop",-0.1,3.94,0.0001437401178668,19.411022297013,511754.463552419,Inf,4.73122070382274,22,-22,0,0,-22,0,0,0,0,-2,0,-2,0,0,0,0,0,3,0,-1,4,0,0,0,0,-0.0116514690982776,0.662414965986395,0.0331260061626323,-0.116453537936914,0.679775280898876,0.852631578947368,-0.967874794069193,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.221,-1.152,"9:9","150/150","Y:K",13.1456002256202,0.924803768446986,139.27718332654,0.0943844491369405,0.0001628371344458,NA,1.28804840845689,0.0292235860951597,1.53426649183163,0.91081598550184,Inf,0.0296198560706035,"lineage2","dr_mutations_pyrazinamide","HIS",0,"ERR2516717","ERR2516717","lineage2.2.1","pe","Peru","pnca_p.tyr103his","A","-","TYR","YA103","pnca_complex.pdb"
|
|
"Y103H","L2","PZA","Y","Y103",103,"H",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","neutral","basic","polar","pos",5.416,-0.046,0.779,0.909501,-0.683,1.21,81,91,-1.175,9,9,138,0.524714828897338,"loop",-0.1,3.94,0.0001437401178668,19.411022297013,511754.463552419,Inf,4.73122070382274,22,-22,0,0,-22,0,0,0,0,-2,0,-2,0,0,0,0,0,3,0,-1,4,0,0,0,0,-0.0116514690982776,0.662414965986395,0.0331260061626323,-0.116453537936914,0.679775280898876,0.852631578947368,-0.967874794069193,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.221,-1.152,"9:9","150/150","Y:K",13.1456002256202,0.924803768446986,139.27718332654,0.0943844491369405,0.0001628371344458,NA,1.28804840845689,0.0292235860951597,1.53426649183163,0.91081598550184,Inf,0.0296198560706035,"lineage2","dr_mutations_pyrazinamide","HIS",0,"SRR5709883,SAMN07236305","SRR5709883","lineage2.1","th","Thailand","pnca_p.tyr103his","A","-","TYR","YA103","pnca_complex.pdb"
|
|
"Y103H","L4","PZA","Y","Y103",103,"H",NA,"MDR","DM","hydrophobic","hydrophobic","neutral","basic","polar","pos",5.416,-0.046,0.779,0.909501,-0.683,1.21,81,91,-1.175,9,9,138,0.524714828897338,"loop",-0.1,3.94,0.0001437401178668,19.411022297013,511754.463552419,Inf,4.73122070382274,22,-22,0,0,-22,0,0,0,0,-2,0,-2,0,0,0,0,0,3,0,-1,4,0,0,0,0,-0.0116514690982776,0.662414965986395,0.0331260061626323,-0.116453537936914,0.679775280898876,0.852631578947368,-0.967874794069193,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.221,-1.152,"9:9","150/150","Y:K",13.1456002256202,0.924803768446986,139.27718332654,0.0943844491369405,0.0001628371344458,NA,1.28804840845689,0.0292235860951597,1.53426649183163,0.91081598550184,Inf,0.0296198560706035,"lineage4","dr_mutations_pyrazinamide","HIS",0,"ERR1213863","ERR1213863","lineage4.2.2","kr","South Korea","pnca_p.tyr103his","A","-","TYR","YA103","pnca_complex.pdb"
|
|
"Y103H","L2","PZA","Y","Y103",103,"H",NA,"MDR","DM","hydrophobic","hydrophobic","neutral","basic","polar","pos",5.416,-0.046,0.779,0.909501,-0.683,1.21,81,91,-1.175,9,9,138,0.524714828897338,"loop",-0.1,3.94,0.0001437401178668,19.411022297013,511754.463552419,Inf,4.73122070382274,22,-22,0,0,-22,0,0,0,0,-2,0,-2,0,0,0,0,0,3,0,-1,4,0,0,0,0,-0.0116514690982776,0.662414965986395,0.0331260061626323,-0.116453537936914,0.679775280898876,0.852631578947368,-0.967874794069193,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.221,-1.152,"9:9","150/150","Y:K",13.1456002256202,0.924803768446986,139.27718332654,0.0943844491369405,0.0001628371344458,NA,1.28804840845689,0.0292235860951597,1.53426649183163,0.91081598550184,Inf,0.0296198560706035,"lineage2","dr_mutations_pyrazinamide","HIS",0,"SRR5073870","SRR5073870","lineage2.2.1","vn","Vietnam","pnca_p.tyr103his","A","-","TYR","YA103","pnca_complex.pdb"
|
|
"Y103H","L2","PZA","Y","Y103",103,"H",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","neutral","basic","polar","pos",5.416,-0.046,0.779,0.909501,-0.683,1.21,81,91,-1.175,9,9,138,0.524714828897338,"loop",-0.1,3.94,0.0001437401178668,19.411022297013,511754.463552419,Inf,4.73122070382274,22,-22,0,0,-22,0,0,0,0,-2,0,-2,0,0,0,0,0,3,0,-1,4,0,0,0,0,-0.0116514690982776,0.662414965986395,0.0331260061626323,-0.116453537936914,0.679775280898876,0.852631578947368,-0.967874794069193,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.221,-1.152,"9:9","150/150","Y:K",13.1456002256202,0.924803768446986,139.27718332654,0.0943844491369405,0.0001628371344458,NA,1.28804840845689,0.0292235860951597,1.53426649183163,0.91081598550184,Inf,0.0296198560706035,"lineage2","dr_mutations_pyrazinamide","HIS",0,"ERR2517096","ERR2517096","lineage2.2.1","gb","UK","pnca_p.tyr103his","A","-","TYR","YA103","pnca_complex.pdb"
|
|
"Y103H","L2","PZA","Y","Y103",103,"H",1,"MDR","DM","hydrophobic","hydrophobic","neutral","basic","polar","pos",5.416,-0.046,0.779,0.909501,-0.683,1.21,81,91,-1.175,9,9,138,0.524714828897338,"loop",-0.1,3.94,0.0001437401178668,19.411022297013,511754.463552419,Inf,4.73122070382274,22,-22,0,0,-22,0,0,0,0,-2,0,-2,0,0,0,0,0,3,0,-1,4,0,0,0,0,-0.0116514690982776,0.662414965986395,0.0331260061626323,-0.116453537936914,0.679775280898876,0.852631578947368,-0.967874794069193,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.221,-1.152,"9:9","150/150","Y:K",13.1456002256202,0.924803768446986,139.27718332654,0.0943844491369405,0.0001628371344458,NA,1.28804840845689,0.0292235860951597,1.53426649183163,0.91081598550184,Inf,0.0296198560706035,"lineage2","dr_mutations_pyrazinamide","HIS",0,"ERS2592812","ERR2677469","lineage2.2.1","de","Germany","pnca_p.tyr103his","A","-","TYR","YA103","pnca_complex.pdb"
|
|
"Y103S","L2","PZA","Y","Y103",103,"S",NA,"MDR","DM","hydrophobic","hydrophilic","neutral","neutral","polar","polar",5.416,-0.062,0.233,1.16175,-0.796,0.42,85,91,-1.175,9,9,138,0.524714828897338,"loop",-0.1,3.94,7.18700589334483e-05,9.70142977291842,188179.926264673,Inf,0.763784339928386,44,4,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,4,2,0,0,2,-0.0157041540020263,0.19812925170068,0.0423134638218519,-0.135720375106564,0.235955056179775,0.894736842105263,-0.967874794069193,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.221,-1.152,"9:9","150/150","Y:K",12.1451538387267,0.919026337424241,119.468044436244,0.101660271548247,5.01153666061564e-06,NA,0.986835744238421,0.170978870202674,0.767057556984365,0.124324963210678,Inf,0.382146811758261,"lineage2","dr_mutations_pyrazinamide","SER",0,"SRS797199","SRR1723718_SRR1723719","lineage2.2.1","cn","China:Anhui","pnca_p.tyr103ser","A","-","TYR","YA103","pnca_complex.pdb"
|
|
"Y103S","L4","PZA","Y","Y103",103,"S",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","neutral","neutral","polar","polar",5.416,-0.062,0.233,1.16175,-0.796,0.42,85,91,-1.175,9,9,138,0.524714828897338,"loop",-0.1,3.94,7.18700589334483e-05,9.70142977291842,188179.926264673,Inf,0.763784339928386,44,4,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,4,2,0,0,2,-0.0157041540020263,0.19812925170068,0.0423134638218519,-0.135720375106564,0.235955056179775,0.894736842105263,-0.967874794069193,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.221,-1.152,"9:9","150/150","Y:K",12.1451538387267,0.919026337424241,119.468044436244,0.101660271548247,5.01153666061564e-06,NA,0.986835744238421,0.170978870202674,0.767057556984365,0.124324963210678,Inf,0.382146811758261,"lineage4","dr_mutations_pyrazinamide","SER",0,"ERR2179679","ERR2179679","lineage4.5","cn","China","pnca_p.tyr103ser","A","-","TYR","YA103","pnca_complex.pdb"
|
|
"Y103S","L4","PZA","Y","Y103",103,"S",1,"Pre-XDR","DM","hydrophobic","hydrophilic","neutral","neutral","polar","polar",5.416,-0.062,0.233,1.16175,-0.796,0.42,85,91,-1.175,9,9,138,0.524714828897338,"loop",-0.1,3.94,7.18700589334483e-05,9.70142977291842,188179.926264673,Inf,0.763784339928386,44,4,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,4,2,0,0,2,-0.0157041540020263,0.19812925170068,0.0423134638218519,-0.135720375106564,0.235955056179775,0.894736842105263,-0.967874794069193,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.221,-1.152,"9:9","150/150","Y:K",12.1451538387267,0.919026337424241,119.468044436244,0.101660271548247,5.01153666061564e-06,NA,0.986835744238421,0.170978870202674,0.767057556984365,0.124324963210678,Inf,0.382146811758261,"lineage4","dr_mutations_pyrazinamide","SER",0,"MDR_24267","SRR6824541","lineage4.5","cn","China: Bijie City, Guizhou Province","pnca_p.tyr103ser","A","-","TYR","YA103","pnca_complex.pdb"
|
|
"Y103S","L4","PZA","Y","Y103",103,"S",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","neutral","neutral","polar","polar",5.416,-0.062,0.233,1.16175,-0.796,0.42,85,91,-1.175,9,9,138,0.524714828897338,"loop",-0.1,3.94,7.18700589334483e-05,9.70142977291842,188179.926264673,Inf,0.763784339928386,44,4,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,4,0,0,4,2,0,0,2,-0.0157041540020263,0.19812925170068,0.0423134638218519,-0.135720375106564,0.235955056179775,0.894736842105263,-0.967874794069193,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.221,-1.152,"9:9","150/150","Y:K",12.1451538387267,0.919026337424241,119.468044436244,0.101660271548247,5.01153666061564e-06,NA,0.986835744238421,0.170978870202674,0.767057556984365,0.124324963210678,Inf,0.382146811758261,"lineage4","dr_mutations_pyrazinamide","SER",0,"SRS797393","SRR1723931","lineage4.5","cn","China:Guizhou","pnca_p.tyr103ser","A","-","TYR","YA103","pnca_complex.pdb"
|
|
"S104G","L2","PZA","S","S104",104,"G",1,"Pre-XDR","DM","hydrophilic","hydrophobic","neutral","neutral","polar","non-polar",6.519,-0.7,-0.671,3.32695,-2.163,-0.68,81,91,-1.214,9,9,1,0.0064516129032258,"loop",-0.833333333333333,5.37,0.0002156101768003,2.42493692178301,2.42493957425811,2.42473736947533,4.31445715363782e-25,4,0,0,0,0,0,0,0,0,4,0,2,2,0,0,0,0,1,0,1,0,2,0,5,15,-0.177304964539007,-0.173385012919897,0.12117476088841,-0.368797953964194,-0.178010471204189,0.852631578947368,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","150/150","S",0.885806606247283,0.469406216824825,1.22442753211922,0.723445514749363,0.112662937620391,25.327054747104,0.384700446081433,0.430258985168156,0.366270051463612,0.0410854444106247,46.5881472867033,0.999999999999476,"lineage2","dr_mutations_pyrazinamide","GLY",0,"ERS457414,SAMEA2534012","ERR551539_ERR551540","lineage2.2.1","uz","Nukus","pnca_p.ser104gly","A","-","SER","SA104","pnca_complex.pdb"
|
|
"S104G","L2","PZA","S","S104",104,"G",0,"Pre-XDR","DM","hydrophilic","hydrophobic","neutral","neutral","polar","non-polar",6.519,-0.7,-0.671,3.32695,-2.163,-0.68,81,91,-1.214,9,9,1,0.0064516129032258,"loop",-0.833333333333333,5.37,0.0002156101768003,2.42493692178301,2.42493957425811,2.42473736947533,4.31445715363782e-25,4,0,0,0,0,0,0,0,0,4,0,2,2,0,0,0,0,1,0,1,0,2,0,5,15,-0.177304964539007,-0.173385012919897,0.12117476088841,-0.368797953964194,-0.178010471204189,0.852631578947368,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","150/150","S",0.885806606247283,0.469406216824825,1.22442753211922,0.723445514749363,0.112662937620391,25.327054747104,0.384700446081433,0.430258985168156,0.366270051463612,0.0410854444106247,46.5881472867033,0.999999999999476,"lineage2","dr_mutations_pyrazinamide","GLY",0,"ERS457103,SAMEA2533701","ERR551099_ERR551100","lineage2.2.1","uz","Nukus","pnca_p.ser104gly","A","-","SER","SA104","pnca_complex.pdb"
|
|
"S104G","L4","PZA","S","S104",104,"G",0,"MDR","DM","hydrophilic","hydrophobic","neutral","neutral","polar","non-polar",6.519,-0.7,-0.671,3.32695,-2.163,-0.68,81,91,-1.214,9,9,1,0.0064516129032258,"loop",-0.833333333333333,5.37,0.0002156101768003,2.42493692178301,2.42493957425811,2.42473736947533,4.31445715363782e-25,4,0,0,0,0,0,0,0,0,4,0,2,2,0,0,0,0,1,0,1,0,2,0,5,15,-0.177304964539007,-0.173385012919897,0.12117476088841,-0.368797953964194,-0.178010471204189,0.852631578947368,-1,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","150/150","S",0.885806606247283,0.469406216824825,1.22442753211922,0.723445514749363,0.112662937620391,25.327054747104,0.384700446081433,0.430258985168156,0.366270051463612,0.0410854444106247,46.5881472867033,0.999999999999476,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR2864260","ERR2864260","lineage4.3.4.1","pt","Portugal","pnca_p.ser104gly","A","-","SER","SA104","pnca_complex.pdb"
|
|
"S104I","L4","PZA","S","S104",104,"I",NA,"MDR","OM","hydrophilic","hydrophobic","neutral","non-polar","polar","non-polar",6.519,-0.295,0.284,0.982352,-1.713,-0.39,82,91,-1.214,9,9,1,0.0064516129032258,"loop",-0.833333333333333,5.37,NA,NA,NA,NA,NA,-18,2,0,0,2,0,0,0,0,2,0,0,2,0,0,0,0,-7,0,-11,0,-10,0,-6,-6,-0.0747213779128672,0.241496598639456,0.0357793981599516,-0.292071611253197,-0.102094240837696,0.863157894736842,-1,"Destabilising","Stabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","150/150","S",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage4","other_mutations_pyrazinamide","ILE",0,"ERR1555060","ERR1555060","lineage4.3.4.2","","","pnca_p.ser104ile","A","-","SER","SA104","pnca_complex.pdb"
|
|
"S104R","L4","PZA","S","S104",104,"R",NA,"XDR","DM","hydrophilic","hydrophilic","neutral","basic","polar","pos",6.519,-0.438,-0.525,-0.736092,-2.325,-0.47,85,91,-1.214,9,9,1,0.0064516129032258,"loop",-0.833333333333333,5.37,0.0005749604714675,14.5802781289507,14.5802277940117,14.5801759034061,15.0663448164144,-68,-30,0,0,-30,0,0,0,0,4,0,0,4,0,0,0,0,-8,0,-4,-9,-2,0,-4,-2,-0.110942249240121,-0.135658914728682,-0.141523494578174,-0.396419437340153,-0.12303664921466,0.894736842105263,-1,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","150/150","S",2.6796663501904,0.0010245352377103,0.816050632122416,3.28370108999367,3.35697961122126,99.5538692592611,1.16376580853041,0.0005075351447614,3.29453387923245,2.60435121163486,147.676327006136,0.0001037975122989,"lineage4","dr_mutations_pyrazinamide","ARG",0,"2370","ERR2432994","lineage4.3.4.1","br","Brazil","pnca_p.ser104arg","A","-","SER","SA104","pnca_complex.pdb"
|
|
"S104R","L2","PZA","S","S104",104,"R",1,"Pre-MDR","DM","hydrophilic","hydrophilic","neutral","basic","polar","pos",6.519,-0.438,-0.525,-0.736092,-2.325,-0.47,85,91,-1.214,9,9,1,0.0064516129032258,"loop",-0.833333333333333,5.37,0.0005749604714675,14.5802781289507,14.5802277940117,14.5801759034061,15.0663448164144,-68,-30,0,0,-30,0,0,0,0,4,0,0,4,0,0,0,0,-8,0,-4,-9,-2,0,-4,-2,-0.110942249240121,-0.135658914728682,-0.141523494578174,-0.396419437340153,-0.12303664921466,0.894736842105263,-1,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","150/150","S",2.6796663501904,0.0010245352377103,0.816050632122416,3.28370108999367,3.35697961122126,99.5538692592611,1.16376580853041,0.0005075351447614,3.29453387923245,2.60435121163486,147.676327006136,0.0001037975122989,"lineage2","dr_mutations_pyrazinamide","ARG",0,"ERR2510408","ERR2510408","lineage2.2.1","pk","Pakistan","pnca_p.ser104arg","A","-","SER","SA104","pnca_complex.pdb"
|
|
"S104R","L1","PZA","S","S104",104,"R",NA,"Other","DM","hydrophilic","hydrophilic","neutral","basic","polar","pos",6.519,-0.438,-0.525,-0.736092,-2.325,-0.47,85,91,-1.214,9,9,1,0.0064516129032258,"loop",-0.833333333333333,5.37,0.0005749604714675,14.5802781289507,14.5802277940117,14.5801759034061,15.0663448164144,-68,-30,0,0,-30,0,0,0,0,4,0,0,4,0,0,0,0,-8,0,-4,-9,-2,0,-4,-2,-0.110942249240121,-0.135658914728682,-0.141523494578174,-0.396419437340153,-0.12303664921466,0.894736842105263,-1,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","150/150","S",2.6796663501904,0.0010245352377103,0.816050632122416,3.28370108999367,3.35697961122126,99.5538692592611,1.16376580853041,0.0005075351447614,3.29453387923245,2.60435121163486,147.676327006136,0.0001037975122989,"lineage1","dr_mutations_pyrazinamide","ARG",0,"ERR751984","ERR751984","lineage1.2.1","th","Thailand","pnca_p.ser104arg","A","-","SER","SA104","pnca_complex.pdb"
|
|
"S104R","L2","PZA","S","S104",104,"R",NA,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","basic","polar","pos",6.519,-0.438,-0.525,-0.736092,-2.325,-0.47,85,91,-1.214,9,9,1,0.0064516129032258,"loop",-0.833333333333333,5.37,0.0005749604714675,14.5802781289507,14.5802277940117,14.5801759034061,15.0663448164144,-68,-30,0,0,-30,0,0,0,0,4,0,0,4,0,0,0,0,-8,0,-4,-9,-2,0,-4,-2,-0.110942249240121,-0.135658914728682,-0.141523494578174,-0.396419437340153,-0.12303664921466,0.894736842105263,-1,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","150/150","S",2.6796663501904,0.0010245352377103,0.816050632122416,3.28370108999367,3.35697961122126,99.5538692592611,1.16376580853041,0.0005075351447614,3.29453387923245,2.60435121163486,147.676327006136,0.0001037975122989,"lineage2","dr_mutations_pyrazinamide","ARG",0,"SAMN02360593","SRR1049019_SRR1049020_SRR1013625_SRR1013626","lineage2.2.2","kr","South Korea","pnca_p.ser104arg","A","-","SER","SA104","pnca_complex.pdb"
|
|
"S104R","L4","PZA","S","S104",104,"R",NA,"MDR","DM","hydrophilic","hydrophilic","neutral","basic","polar","pos",6.519,-0.438,-0.525,-0.736092,-2.325,-0.47,85,91,-1.214,9,9,1,0.0064516129032258,"loop",-0.833333333333333,5.37,0.0005749604714675,14.5802781289507,14.5802277940117,14.5801759034061,15.0663448164144,-68,-30,0,0,-30,0,0,0,0,4,0,0,4,0,0,0,0,-8,0,-4,-9,-2,0,-4,-2,-0.110942249240121,-0.135658914728682,-0.141523494578174,-0.396419437340153,-0.12303664921466,0.894736842105263,-1,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","150/150","S",2.6796663501904,0.0010245352377103,0.816050632122416,3.28370108999367,3.35697961122126,99.5538692592611,1.16376580853041,0.0005075351447614,3.29453387923245,2.60435121163486,147.676327006136,0.0001037975122989,"lineage4","dr_mutations_pyrazinamide","ARG",0,"SAMN02403634","SRR1165231_SRR1173260_SRR1167318_SRR1175330","lineage4.3.2.1","za","South Africa","pnca_p.ser104arg","A","-","SER","SA104","pnca_complex.pdb"
|
|
"S104R","L1","PZA","S","S104",104,"R",NA,"Other","DM","hydrophilic","hydrophilic","neutral","basic","polar","pos",6.519,-0.438,-0.525,-0.736092,-2.325,-0.47,85,91,-1.214,9,9,1,0.0064516129032258,"loop",-0.833333333333333,5.37,0.0005749604714675,14.5802781289507,14.5802277940117,14.5801759034061,15.0663448164144,-68,-30,0,0,-30,0,0,0,0,4,0,0,4,0,0,0,0,-8,0,-4,-9,-2,0,-4,-2,-0.110942249240121,-0.135658914728682,-0.141523494578174,-0.396419437340153,-0.12303664921466,0.894736842105263,-1,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","150/150","S",2.6796663501904,0.0010245352377103,0.816050632122416,3.28370108999367,3.35697961122126,99.5538692592611,1.16376580853041,0.0005075351447614,3.29453387923245,2.60435121163486,147.676327006136,0.0001037975122989,"lineage1","dr_mutations_pyrazinamide","ARG",0,"ERR768003","ERR768003","lineage1.2.1","th","Thailand","pnca_p.ser104arg","A","-","SER","SA104","pnca_complex.pdb"
|
|
"S104R","L1","PZA","S","S104",104,"R",NA,"Other","DM","hydrophilic","hydrophilic","neutral","basic","polar","pos",6.519,-0.438,-0.525,-0.736092,-2.325,-0.47,85,91,-1.214,9,9,1,0.0064516129032258,"loop",-0.833333333333333,5.37,0.0005749604714675,14.5802781289507,14.5802277940117,14.5801759034061,15.0663448164144,-68,-30,0,0,-30,0,0,0,0,4,0,0,4,0,0,0,0,-8,0,-4,-9,-2,0,-4,-2,-0.110942249240121,-0.135658914728682,-0.141523494578174,-0.396419437340153,-0.12303664921466,0.894736842105263,-1,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","150/150","S",2.6796663501904,0.0010245352377103,0.816050632122416,3.28370108999367,3.35697961122126,99.5538692592611,1.16376580853041,0.0005075351447614,3.29453387923245,2.60435121163486,147.676327006136,0.0001037975122989,"lineage1","dr_mutations_pyrazinamide","ARG",0,"ERR751726","ERR751726","lineage1.2.1","th","Thailand","pnca_p.ser104arg","A","-","SER","SA104","pnca_complex.pdb"
|
|
"S104R","L2","PZA","S","S104",104,"R",NA,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","basic","polar","pos",6.519,-0.438,-0.525,-0.736092,-2.325,-0.47,85,91,-1.214,9,9,1,0.0064516129032258,"loop",-0.833333333333333,5.37,0.0005749604714675,14.5802781289507,14.5802277940117,14.5801759034061,15.0663448164144,-68,-30,0,0,-30,0,0,0,0,4,0,0,4,0,0,0,0,-8,0,-4,-9,-2,0,-4,-2,-0.110942249240121,-0.135658914728682,-0.141523494578174,-0.396419437340153,-0.12303664921466,0.894736842105263,-1,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","150/150","S",2.6796663501904,0.0010245352377103,0.816050632122416,3.28370108999367,3.35697961122126,99.5538692592611,1.16376580853041,0.0005075351447614,3.29453387923245,2.60435121163486,147.676327006136,0.0001037975122989,"lineage2","dr_mutations_pyrazinamide","ARG",0,"SAMN02360622","SRR1003102_SRR1003103","lineage2.2.1","kr","South Korea","pnca_p.ser104arg","A","-","SER","SA104","pnca_complex.pdb"
|
|
"S104R","L2","PZA","S","S104",104,"R",NA,"MDR","DM","hydrophilic","hydrophilic","neutral","basic","polar","pos",6.519,-0.438,-0.525,-0.736092,-2.325,-0.47,85,91,-1.214,9,9,1,0.0064516129032258,"loop",-0.833333333333333,5.37,0.0005749604714675,14.5802781289507,14.5802277940117,14.5801759034061,15.0663448164144,-68,-30,0,0,-30,0,0,0,0,4,0,0,4,0,0,0,0,-8,0,-4,-9,-2,0,-4,-2,-0.110942249240121,-0.135658914728682,-0.141523494578174,-0.396419437340153,-0.12303664921466,0.894736842105263,-1,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","150/150","S",2.6796663501904,0.0010245352377103,0.816050632122416,3.28370108999367,3.35697961122126,99.5538692592611,1.16376580853041,0.0005075351447614,3.29453387923245,2.60435121163486,147.676327006136,0.0001037975122989,"lineage2","dr_mutations_pyrazinamide","ARG",0,"SRR5065336","SRR5065336","lineage2.2.1","vn","Vietnam","pnca_p.ser104arg","A","-","SER","SA104","pnca_complex.pdb"
|
|
"S104R","L2","PZA","S","S104",104,"R",1,"MDR","DM","hydrophilic","hydrophilic","neutral","basic","polar","pos",6.519,-0.438,-0.525,-0.736092,-2.325,-0.47,85,91,-1.214,9,9,1,0.0064516129032258,"loop",-0.833333333333333,5.37,0.0005749604714675,14.5802781289507,14.5802277940117,14.5801759034061,15.0663448164144,-68,-30,0,0,-30,0,0,0,0,4,0,0,4,0,0,0,0,-8,0,-4,-9,-2,0,-4,-2,-0.110942249240121,-0.135658914728682,-0.141523494578174,-0.396419437340153,-0.12303664921466,0.894736842105263,-1,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","150/150","S",2.6796663501904,0.0010245352377103,0.816050632122416,3.28370108999367,3.35697961122126,99.5538692592611,1.16376580853041,0.0005075351447614,3.29453387923245,2.60435121163486,147.676327006136,0.0001037975122989,"lineage2","dr_mutations_pyrazinamide","ARG",0,"MDR_3271","SRR6824489","lineage2.2.1","cn","China: Jize County, Handan City, Hebei Province","pnca_p.ser104arg","A","-","SER","SA104","pnca_complex.pdb"
|
|
"S104R","L1","PZA","S","S104",104,"R",NA,"Pre-MDR","DM","hydrophilic","hydrophilic","neutral","basic","polar","pos",6.519,-0.438,-0.525,-0.736092,-2.325,-0.47,85,91,-1.214,9,9,1,0.0064516129032258,"loop",-0.833333333333333,5.37,0.0005749604714675,14.5802781289507,14.5802277940117,14.5801759034061,15.0663448164144,-68,-30,0,0,-30,0,0,0,0,4,0,0,4,0,0,0,0,-8,0,-4,-9,-2,0,-4,-2,-0.110942249240121,-0.135658914728682,-0.141523494578174,-0.396419437340153,-0.12303664921466,0.894736842105263,-1,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","150/150","S",2.6796663501904,0.0010245352377103,0.816050632122416,3.28370108999367,3.35697961122126,99.5538692592611,1.16376580853041,0.0005075351447614,3.29453387923245,2.60435121163486,147.676327006136,0.0001037975122989,"lineage1","dr_mutations_pyrazinamide","ARG",0,"ERR1023300","ERR1023300","lineage1.2.1","","","pnca_p.ser104arg","A","-","SER","SA104","pnca_complex.pdb"
|
|
"S104R","L1","PZA","S","S104",104,"R",1,"Other","DM","hydrophilic","hydrophilic","neutral","basic","polar","pos",6.519,-0.438,-0.525,-0.736092,-2.325,-0.47,85,91,-1.214,9,9,1,0.0064516129032258,"loop",-0.833333333333333,5.37,0.0005749604714675,14.5802781289507,14.5802277940117,14.5801759034061,15.0663448164144,-68,-30,0,0,-30,0,0,0,0,4,0,0,4,0,0,0,0,-8,0,-4,-9,-2,0,-4,-2,-0.110942249240121,-0.135658914728682,-0.141523494578174,-0.396419437340153,-0.12303664921466,0.894736842105263,-1,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","150/150","S",2.6796663501904,0.0010245352377103,0.816050632122416,3.28370108999367,3.35697961122126,99.5538692592611,1.16376580853041,0.0005075351447614,3.29453387923245,2.60435121163486,147.676327006136,0.0001037975122989,"lineage1","dr_mutations_pyrazinamide","ARG",0,"SAMN03647998,SRR2100825","SRR2100825","lineage1.2.1","","","pnca_p.ser104arg","A","-","SER","SA104","pnca_complex.pdb"
|
|
"S104R","L2","PZA","S","S104",104,"R",NA,"XDR","DM","hydrophilic","hydrophilic","neutral","basic","polar","pos",6.519,-0.438,-0.525,-0.736092,-2.325,-0.47,85,91,-1.214,9,9,1,0.0064516129032258,"loop",-0.833333333333333,5.37,0.0005749604714675,14.5802781289507,14.5802277940117,14.5801759034061,15.0663448164144,-68,-30,0,0,-30,0,0,0,0,4,0,0,4,0,0,0,0,-8,0,-4,-9,-2,0,-4,-2,-0.110942249240121,-0.135658914728682,-0.141523494578174,-0.396419437340153,-0.12303664921466,0.894736842105263,-1,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","150/150","S",2.6796663501904,0.0010245352377103,0.816050632122416,3.28370108999367,3.35697961122126,99.5538692592611,1.16376580853041,0.0005075351447614,3.29453387923245,2.60435121163486,147.676327006136,0.0001037975122989,"lineage2","dr_mutations_pyrazinamide","ARG",0,"SAMN07236318,SRR5709863","SRR5709863","lineage2.2.1","th","Thailand","pnca_p.ser104arg","A","-","SER","SA104","pnca_complex.pdb"
|
|
"S104R","L2","PZA","S","S104",104,"R",NA,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","basic","polar","pos",6.519,-0.438,-0.525,-0.736092,-2.325,-0.47,85,91,-1.214,9,9,1,0.0064516129032258,"loop",-0.833333333333333,5.37,0.0005749604714675,14.5802781289507,14.5802277940117,14.5801759034061,15.0663448164144,-68,-30,0,0,-30,0,0,0,0,4,0,0,4,0,0,0,0,-8,0,-4,-9,-2,0,-4,-2,-0.110942249240121,-0.135658914728682,-0.141523494578174,-0.396419437340153,-0.12303664921466,0.894736842105263,-1,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","150/150","S",2.6796663501904,0.0010245352377103,0.816050632122416,3.28370108999367,3.35697961122126,99.5538692592611,1.16376580853041,0.0005075351447614,3.29453387923245,2.60435121163486,147.676327006136,0.0001037975122989,"lineage2","dr_mutations_pyrazinamide","ARG",0,"SAMN02360548","SRR1048836_SRR1013538_SRR1048835_SRR1013537","lineage2.2.1","kr","South Korea","pnca_p.ser104arg","A","-","SER","SA104","pnca_complex.pdb"
|
|
"S104R","L5","PZA","S","S104",104,"R",NA,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","basic","polar","pos",6.519,-0.438,-0.525,-0.736092,-2.325,-0.47,85,91,-1.214,9,9,1,0.0064516129032258,"loop",-0.833333333333333,5.37,0.0005749604714675,14.5802781289507,14.5802277940117,14.5801759034061,15.0663448164144,-68,-30,0,0,-30,0,0,0,0,4,0,0,4,0,0,0,0,-8,0,-4,-9,-2,0,-4,-2,-0.110942249240121,-0.135658914728682,-0.141523494578174,-0.396419437340153,-0.12303664921466,0.894736842105263,-1,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","150/150","S",2.6796663501904,0.0010245352377103,0.816050632122416,3.28370108999367,3.35697961122126,99.5538692592611,1.16376580853041,0.0005075351447614,3.29453387923245,2.60435121163486,147.676327006136,0.0001037975122989,"lineage5","dr_mutations_pyrazinamide","ARG",0,"ERR2383627","ERR2383627","lineage5","fr","","pnca_p.ser104arg","A","-","SER","SA104","pnca_complex.pdb"
|
|
"S104R","L2","PZA","S","S104",104,"R",NA,"Pre-MDR","DM","hydrophilic","hydrophilic","neutral","basic","polar","pos",6.519,-0.438,-0.525,-0.736092,-2.325,-0.47,85,91,-1.214,9,9,1,0.0064516129032258,"loop",-0.833333333333333,5.37,0.0005749604714675,14.5802781289507,14.5802277940117,14.5801759034061,15.0663448164144,-68,-30,0,0,-30,0,0,0,0,4,0,0,4,0,0,0,0,-8,0,-4,-9,-2,0,-4,-2,-0.110942249240121,-0.135658914728682,-0.141523494578174,-0.396419437340153,-0.12303664921466,0.894736842105263,-1,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","150/150","S",2.6796663501904,0.0010245352377103,0.816050632122416,3.28370108999367,3.35697961122126,99.5538692592611,1.16376580853041,0.0005075351447614,3.29453387923245,2.60435121163486,147.676327006136,0.0001037975122989,"lineage2","dr_mutations_pyrazinamide","ARG",0,"DRR184609","DRR184609","lineage2.2.1","vn","Vietnam","pnca_p.ser104arg","A","-","SER","SA104","pnca_complex.pdb"
|
|
"S104R","L1","PZA","S","S104",104,"R",NA,"Other","DM","hydrophilic","hydrophilic","neutral","basic","polar","pos",6.519,-0.438,-0.525,-0.736092,-2.325,-0.47,85,91,-1.214,9,9,1,0.0064516129032258,"loop",-0.833333333333333,5.37,0.0005749604714675,14.5802781289507,14.5802277940117,14.5801759034061,15.0663448164144,-68,-30,0,0,-30,0,0,0,0,4,0,0,4,0,0,0,0,-8,0,-4,-9,-2,0,-4,-2,-0.110942249240121,-0.135658914728682,-0.141523494578174,-0.396419437340153,-0.12303664921466,0.894736842105263,-1,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","150/150","S",2.6796663501904,0.0010245352377103,0.816050632122416,3.28370108999367,3.35697961122126,99.5538692592611,1.16376580853041,0.0005075351447614,3.29453387923245,2.60435121163486,147.676327006136,0.0001037975122989,"lineage1","dr_mutations_pyrazinamide","ARG",0,"ERR751829","ERR751829","lineage1.2.1","th","Thailand","pnca_p.ser104arg","A","-","SER","SA104","pnca_complex.pdb"
|
|
"S104R","L4","PZA","S","S104",104,"R",1,"MDR","DM","hydrophilic","hydrophilic","neutral","basic","polar","pos",6.519,-0.438,-0.525,-0.736092,-2.325,-0.47,85,91,-1.214,9,9,1,0.0064516129032258,"loop",-0.833333333333333,5.37,0.0005749604714675,14.5802781289507,14.5802277940117,14.5801759034061,15.0663448164144,-68,-30,0,0,-30,0,0,0,0,4,0,0,4,0,0,0,0,-8,0,-4,-9,-2,0,-4,-2,-0.110942249240121,-0.135658914728682,-0.141523494578174,-0.396419437340153,-0.12303664921466,0.894736842105263,-1,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","150/150","S",2.6796663501904,0.0010245352377103,0.816050632122416,3.28370108999367,3.35697961122126,99.5538692592611,1.16376580853041,0.0005075351447614,3.29453387923245,2.60435121163486,147.676327006136,0.0001037975122989,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERR2516810","ERR2516810","lineage4.8","gb","UK","pnca_p.ser104arg","A","-","SER","SA104","pnca_complex.pdb"
|
|
"S104R","L2","PZA","S","S104",104,"R",NA,"MDR","DM","hydrophilic","hydrophilic","neutral","basic","polar","pos",6.519,-0.438,-0.525,-0.736092,-2.325,-0.47,85,91,-1.214,9,9,1,0.0064516129032258,"loop",-0.833333333333333,5.37,0.0005749604714675,14.5802781289507,14.5802277940117,14.5801759034061,15.0663448164144,-68,-30,0,0,-30,0,0,0,0,4,0,0,4,0,0,0,0,-8,0,-4,-9,-2,0,-4,-2,-0.110942249240121,-0.135658914728682,-0.141523494578174,-0.396419437340153,-0.12303664921466,0.894736842105263,-1,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","150/150","S",2.6796663501904,0.0010245352377103,0.816050632122416,3.28370108999367,3.35697961122126,99.5538692592611,1.16376580853041,0.0005075351447614,3.29453387923245,2.60435121163486,147.676327006136,0.0001037975122989,"lineage2","dr_mutations_pyrazinamide","ARG",0,"SAMN02403538","SRR1165634_SRR1172294_SRR1167327_SRR1169192","lineage2.2.1","za","South Africa","pnca_p.ser104arg","A","-","SER","SA104","pnca_complex.pdb"
|
|
"S104R","L2","PZA","S","S104",104,"R",1,"MDR","DM","hydrophilic","hydrophilic","neutral","basic","polar","pos",6.519,-0.438,-0.525,-0.736092,-2.325,-0.47,85,91,-1.214,9,9,1,0.0064516129032258,"loop",-0.833333333333333,5.37,0.0005749604714675,14.5802781289507,14.5802277940117,14.5801759034061,15.0663448164144,-68,-30,0,0,-30,0,0,0,0,4,0,0,4,0,0,0,0,-8,0,-4,-9,-2,0,-4,-2,-0.110942249240121,-0.135658914728682,-0.141523494578174,-0.396419437340153,-0.12303664921466,0.894736842105263,-1,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","150/150","S",2.6796663501904,0.0010245352377103,0.816050632122416,3.28370108999367,3.35697961122126,99.5538692592611,1.16376580853041,0.0005075351447614,3.29453387923245,2.60435121163486,147.676327006136,0.0001037975122989,"lineage2","dr_mutations_pyrazinamide","ARG",0,"SRR5817478","SRR5817478","lineage2.2.2","au","Australia","pnca_p.ser104arg","A","-","SER","SA104","pnca_complex.pdb"
|
|
"S104R","L2","PZA","S","S104",104,"R",NA,"MDR","DM","hydrophilic","hydrophilic","neutral","basic","polar","pos",6.519,-0.438,-0.525,-0.736092,-2.325,-0.47,85,91,-1.214,9,9,1,0.0064516129032258,"loop",-0.833333333333333,5.37,0.0005749604714675,14.5802781289507,14.5802277940117,14.5801759034061,15.0663448164144,-68,-30,0,0,-30,0,0,0,0,4,0,0,4,0,0,0,0,-8,0,-4,-9,-2,0,-4,-2,-0.110942249240121,-0.135658914728682,-0.141523494578174,-0.396419437340153,-0.12303664921466,0.894736842105263,-1,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","150/150","S",2.6796663501904,0.0010245352377103,0.816050632122416,3.28370108999367,3.35697961122126,99.5538692592611,1.16376580853041,0.0005075351447614,3.29453387923245,2.60435121163486,147.676327006136,0.0001037975122989,"lineage2","dr_mutations_pyrazinamide","ARG",0,"SAMN02585980","SRR1181061_SRR1184014_SRR1180259_SRR1180378","lineage2.2.1","za","South Africa","pnca_p.ser104arg","A","-","SER","SA104","pnca_complex.pdb"
|
|
"S104R","L2","PZA","S","S104",104,"R",NA,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","basic","polar","pos",6.519,-0.438,-0.525,-0.736092,-2.325,-0.47,85,91,-1.214,9,9,1,0.0064516129032258,"loop",-0.833333333333333,5.37,0.0005749604714675,14.5802781289507,14.5802277940117,14.5801759034061,15.0663448164144,-68,-30,0,0,-30,0,0,0,0,4,0,0,4,0,0,0,0,-8,0,-4,-9,-2,0,-4,-2,-0.110942249240121,-0.135658914728682,-0.141523494578174,-0.396419437340153,-0.12303664921466,0.894736842105263,-1,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","150/150","S",2.6796663501904,0.0010245352377103,0.816050632122416,3.28370108999367,3.35697961122126,99.5538692592611,1.16376580853041,0.0005075351447614,3.29453387923245,2.60435121163486,147.676327006136,0.0001037975122989,"lineage2","dr_mutations_pyrazinamide","ARG",0,"SAMN02414954","SRR1162829_SRR1165541_SRR1165597_SRR1166875","lineage2.2.1","se","Sweden","pnca_p.ser104arg","A","-","SER","SA104","pnca_complex.pdb"
|
|
"S104R","L2","PZA","S","S104",104,"R",NA,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","basic","polar","pos",6.519,-0.438,-0.525,-0.736092,-2.325,-0.47,85,91,-1.214,9,9,1,0.0064516129032258,"loop",-0.833333333333333,5.37,0.0005749604714675,14.5802781289507,14.5802277940117,14.5801759034061,15.0663448164144,-68,-30,0,0,-30,0,0,0,0,4,0,0,4,0,0,0,0,-8,0,-4,-9,-2,0,-4,-2,-0.110942249240121,-0.135658914728682,-0.141523494578174,-0.396419437340153,-0.12303664921466,0.894736842105263,-1,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","150/150","S",2.6796663501904,0.0010245352377103,0.816050632122416,3.28370108999367,3.35697961122126,99.5538692592611,1.16376580853041,0.0005075351447614,3.29453387923245,2.60435121163486,147.676327006136,0.0001037975122989,"lineage2","dr_mutations_pyrazinamide","ARG",0,"SAMN02360549","SRR1013539_SRR1048838_SRR1013540_SRR1048839","lineage2.2.1","kr","South Korea","pnca_p.ser104arg","A","-","SER","SA104","pnca_complex.pdb"
|
|
"S104R","L4","PZA","S","S104",104,"R",NA,"MDR","DM","hydrophilic","hydrophilic","neutral","basic","polar","pos",6.519,-0.438,-0.525,-0.736092,-2.325,-0.47,85,91,-1.214,9,9,1,0.0064516129032258,"loop",-0.833333333333333,5.37,0.0005749604714675,14.5802781289507,14.5802277940117,14.5801759034061,15.0663448164144,-68,-30,0,0,-30,0,0,0,0,4,0,0,4,0,0,0,0,-8,0,-4,-9,-2,0,-4,-2,-0.110942249240121,-0.135658914728682,-0.141523494578174,-0.396419437340153,-0.12303664921466,0.894736842105263,-1,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","150/150","S",2.6796663501904,0.0010245352377103,0.816050632122416,3.28370108999367,3.35697961122126,99.5538692592611,1.16376580853041,0.0005075351447614,3.29453387923245,2.60435121163486,147.676327006136,0.0001037975122989,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERR2679273","ERR2679273","lineage4.1","","","pnca_p.ser104arg","A","-","SER","SA104","pnca_complex.pdb"
|
|
"S104R","L1","PZA","S","S104",104,"R",1,"Other","DM","hydrophilic","hydrophilic","neutral","basic","polar","pos",6.519,-0.438,-0.525,-0.736092,-2.325,-0.47,85,91,-1.214,9,9,1,0.0064516129032258,"loop",-0.833333333333333,5.37,0.0005749604714675,14.5802781289507,14.5802277940117,14.5801759034061,15.0663448164144,-68,-30,0,0,-30,0,0,0,0,4,0,0,4,0,0,0,0,-8,0,-4,-9,-2,0,-4,-2,-0.110942249240121,-0.135658914728682,-0.141523494578174,-0.396419437340153,-0.12303664921466,0.894736842105263,-1,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","150/150","S",2.6796663501904,0.0010245352377103,0.816050632122416,3.28370108999367,3.35697961122126,99.5538692592611,1.16376580853041,0.0005075351447614,3.29453387923245,2.60435121163486,147.676327006136,0.0001037975122989,"lineage1","dr_mutations_pyrazinamide","ARG",0,"SAMN03648069,SRR2100896","SRR2100896","lineage1.2.1","","","pnca_p.ser104arg","A","-","SER","SA104","pnca_complex.pdb"
|
|
"S104R","L4","PZA","S","S104",104,"R",0,"MDR","DM","hydrophilic","hydrophilic","neutral","basic","polar","pos",6.519,-0.438,-0.525,-0.736092,-2.325,-0.47,85,91,-1.214,9,9,1,0.0064516129032258,"loop",-0.833333333333333,5.37,0.0005749604714675,14.5802781289507,14.5802277940117,14.5801759034061,15.0663448164144,-68,-30,0,0,-30,0,0,0,0,4,0,0,4,0,0,0,0,-8,0,-4,-9,-2,0,-4,-2,-0.110942249240121,-0.135658914728682,-0.141523494578174,-0.396419437340153,-0.12303664921466,0.894736842105263,-1,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","150/150","S",2.6796663501904,0.0010245352377103,0.816050632122416,3.28370108999367,3.35697961122126,99.5538692592611,1.16376580853041,0.0005075351447614,3.29453387923245,2.60435121163486,147.676327006136,0.0001037975122989,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERR2516945","ERR2516945","lineage4.8","gb","UK","pnca_p.ser104arg","A","-","SER","SA104","pnca_complex.pdb"
|
|
"S104R","L2","PZA","S","S104",104,"R",NA,"XDR","DM","hydrophilic","hydrophilic","neutral","basic","polar","pos",6.519,-0.438,-0.525,-0.736092,-2.325,-0.47,85,91,-1.214,9,9,1,0.0064516129032258,"loop",-0.833333333333333,5.37,0.0005749604714675,14.5802781289507,14.5802277940117,14.5801759034061,15.0663448164144,-68,-30,0,0,-30,0,0,0,0,4,0,0,4,0,0,0,0,-8,0,-4,-9,-2,0,-4,-2,-0.110942249240121,-0.135658914728682,-0.141523494578174,-0.396419437340153,-0.12303664921466,0.894736842105263,-1,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","150/150","S",2.6796663501904,0.0010245352377103,0.816050632122416,3.28370108999367,3.35697961122126,99.5538692592611,1.16376580853041,0.0005075351447614,3.29453387923245,2.60435121163486,147.676327006136,0.0001037975122989,"lineage2","dr_mutations_pyrazinamide","ARG",0,"SRR5709903,SAMN07236303","SRR5709903","lineage2.2.1","th","Thailand","pnca_p.ser104arg","A","-","SER","SA104","pnca_complex.pdb"
|
|
"S104R","L2","PZA","S","S104",104,"R",NA,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","basic","polar","pos",6.519,-0.438,-0.525,-0.736092,-2.325,-0.47,85,91,-1.214,9,9,1,0.0064516129032258,"loop",-0.833333333333333,5.37,0.0005749604714675,14.5802781289507,14.5802277940117,14.5801759034061,15.0663448164144,-68,-30,0,0,-30,0,0,0,0,4,0,0,4,0,0,0,0,-8,0,-4,-9,-2,0,-4,-2,-0.110942249240121,-0.135658914728682,-0.141523494578174,-0.396419437340153,-0.12303664921466,0.894736842105263,-1,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","150/150","S",2.6796663501904,0.0010245352377103,0.816050632122416,3.28370108999367,3.35697961122126,99.5538692592611,1.16376580853041,0.0005075351447614,3.29453387923245,2.60435121163486,147.676327006136,0.0001037975122989,"lineage2","dr_mutations_pyrazinamide","ARG",0,"SAMN02360621","SRR1003100_SRR1003099","lineage2.2.1","kr","South Korea","pnca_p.ser104arg","A","-","SER","SA104","pnca_complex.pdb"
|
|
"S104R","L1","PZA","S","S104",104,"R",NA,"Other","DM","hydrophilic","hydrophilic","neutral","basic","polar","pos",6.519,-0.438,-0.525,-0.736092,-2.325,-0.47,85,91,-1.214,9,9,1,0.0064516129032258,"loop",-0.833333333333333,5.37,0.0005749604714675,14.5802781289507,14.5802277940117,14.5801759034061,15.0663448164144,-68,-30,0,0,-30,0,0,0,0,4,0,0,4,0,0,0,0,-8,0,-4,-9,-2,0,-4,-2,-0.110942249240121,-0.135658914728682,-0.141523494578174,-0.396419437340153,-0.12303664921466,0.894736842105263,-1,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","150/150","S",2.6796663501904,0.0010245352377103,0.816050632122416,3.28370108999367,3.35697961122126,99.5538692592611,1.16376580853041,0.0005075351447614,3.29453387923245,2.60435121163486,147.676327006136,0.0001037975122989,"lineage1","dr_mutations_pyrazinamide","ARG",0,"SRR6153236","SRR6153236","lineage1.2.1","ca","Canada","pnca_p.ser104arg","A","-","SER","SA104","pnca_complex.pdb"
|
|
"S104R","L4","PZA","S","S104",104,"R",0,"MDR","DM","hydrophilic","hydrophilic","neutral","basic","polar","pos",6.519,-0.438,-0.525,-0.736092,-2.325,-0.47,85,91,-1.214,9,9,1,0.0064516129032258,"loop",-0.833333333333333,5.37,0.0005749604714675,14.5802781289507,14.5802277940117,14.5801759034061,15.0663448164144,-68,-30,0,0,-30,0,0,0,0,4,0,0,4,0,0,0,0,-8,0,-4,-9,-2,0,-4,-2,-0.110942249240121,-0.135658914728682,-0.141523494578174,-0.396419437340153,-0.12303664921466,0.894736842105263,-1,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","150/150","S",2.6796663501904,0.0010245352377103,0.816050632122416,3.28370108999367,3.35697961122126,99.5538692592611,1.16376580853041,0.0005075351447614,3.29453387923245,2.60435121163486,147.676327006136,0.0001037975122989,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERR2510858","ERR2510858","lineage4.1.2.1","it","Italy","pnca_p.ser104arg","A","-","SER","SA104","pnca_complex.pdb"
|
|
"S104R","L2","PZA","S","S104",104,"R",NA,"Pre-MDR","DM","hydrophilic","hydrophilic","neutral","basic","polar","pos",6.519,-0.438,-0.525,-0.736092,-2.325,-0.47,85,91,-1.214,9,9,1,0.0064516129032258,"loop",-0.833333333333333,5.37,0.0005749604714675,14.5802781289507,14.5802277940117,14.5801759034061,15.0663448164144,-68,-30,0,0,-30,0,0,0,0,4,0,0,4,0,0,0,0,-8,0,-4,-9,-2,0,-4,-2,-0.110942249240121,-0.135658914728682,-0.141523494578174,-0.396419437340153,-0.12303664921466,0.894736842105263,-1,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.229,-1.201,"9:9","150/150","S",2.6796663501904,0.0010245352377103,0.816050632122416,3.28370108999367,3.35697961122126,99.5538692592611,1.16376580853041,0.0005075351447614,3.29453387923245,2.60435121163486,147.676327006136,0.0001037975122989,"lineage2","dr_mutations_pyrazinamide","ARG",0,"SAMN02053798","SRR833159_SRR833170_SRR833190","lineage2.2.1","za","South Africa","pnca_p.ser104arg","A","-","SER","SA104","pnca_complex.pdb"
|
|
"G105D","L4","PZA","G","G105",105,"D",1,"Pre-XDR","DM","hydrophobic","hydrophilic","neutral","acidic","non-polar","neg",7.858,0.709,-1.651,2.15123,-2.29,-1.54,79,85,-0.506,7,7,0,0,"helix",0.533333333333333,7.04,0.0001437401178668,19.411022297013,511754.463553489,Inf,4.73122070382274,-20,-32,0,0,-32,0,0,0,0,-2,0,2,-2,0,0,0,0,-5,0,0,-5,-18,0,-15,-25,0.317937219730942,-0.426614987080103,0.0783524792575703,-0.390451832907076,-0.403141361256544,0.831578947368421,-0.416803953871499,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.674,-0.411,"7:7","150/150","A:S:M:G:I:V:L",13.1456002256223,0.924803768447052,139.277183326685,0.0943844491368573,0.0001628371344425,NA,1.28804840845689,0.0292235860951597,1.53426649183163,0.91081598550184,Inf,0.0296198560706035,"lineage4","dr_mutations_pyrazinamide","ASP",0,"ERR2510421","ERR2510421","lineage4.1.1.1","pk","Pakistan","pnca_p.gly105asp","A","G","GLY","GA105","pnca_complex.pdb"
|
|
"G105D","L4","PZA","G","G105",105,"D",NA,"Pre-MDR","DM","hydrophobic","hydrophilic","neutral","acidic","non-polar","neg",7.858,0.709,-1.651,2.15123,-2.29,-1.54,79,85,-0.506,7,7,0,0,"helix",0.533333333333333,7.04,0.0001437401178668,19.411022297013,511754.463553489,Inf,4.73122070382274,-20,-32,0,0,-32,0,0,0,0,-2,0,2,-2,0,0,0,0,-5,0,0,-5,-18,0,-15,-25,0.317937219730942,-0.426614987080103,0.0783524792575703,-0.390451832907076,-0.403141361256544,0.831578947368421,-0.416803953871499,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.674,-0.411,"7:7","150/150","A:S:M:G:I:V:L",13.1456002256223,0.924803768447052,139.277183326685,0.0943844491368573,0.0001628371344425,NA,1.28804840845689,0.0292235860951597,1.53426649183163,0.91081598550184,Inf,0.0296198560706035,"lineage4","dr_mutations_pyrazinamide","ASP",0,"ERR1213945","ERR1213945","lineage4.1.1.1","bd","Bangladesh","pnca_p.gly105asp","A","G","GLY","GA105","pnca_complex.pdb"
|
|
"G105D","L2","PZA","G","G105",105,"D",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","neutral","acidic","non-polar","neg",7.858,0.709,-1.651,2.15123,-2.29,-1.54,79,85,-0.506,7,7,0,0,"helix",0.533333333333333,7.04,0.0001437401178668,19.411022297013,511754.463553489,Inf,4.73122070382274,-20,-32,0,0,-32,0,0,0,0,-2,0,2,-2,0,0,0,0,-5,0,0,-5,-18,0,-15,-25,0.317937219730942,-0.426614987080103,0.0783524792575703,-0.390451832907076,-0.403141361256544,0.831578947368421,-0.416803953871499,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.674,-0.411,"7:7","150/150","A:S:M:G:I:V:L",13.1456002256223,0.924803768447052,139.277183326685,0.0943844491368573,0.0001628371344425,NA,1.28804840845689,0.0292235860951597,1.53426649183163,0.91081598550184,Inf,0.0296198560706035,"lineage2","dr_mutations_pyrazinamide","ASP",0,"SAMN07236299,SRR5709748","SRR5709748","lineage2.1","th","Thailand","pnca_p.gly105asp","A","G","GLY","GA105","pnca_complex.pdb"
|
|
"G105D","L4","PZA","G","G105",105,"D",NA,"MDR","DM","hydrophobic","hydrophilic","neutral","acidic","non-polar","neg",7.858,0.709,-1.651,2.15123,-2.29,-1.54,79,85,-0.506,7,7,0,0,"helix",0.533333333333333,7.04,0.0001437401178668,19.411022297013,511754.463553489,Inf,4.73122070382274,-20,-32,0,0,-32,0,0,0,0,-2,0,2,-2,0,0,0,0,-5,0,0,-5,-18,0,-15,-25,0.317937219730942,-0.426614987080103,0.0783524792575703,-0.390451832907076,-0.403141361256544,0.831578947368421,-0.416803953871499,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.674,-0.411,"7:7","150/150","A:S:M:G:I:V:L",13.1456002256223,0.924803768447052,139.277183326685,0.0943844491368573,0.0001628371344425,NA,1.28804840845689,0.0292235860951597,1.53426649183163,0.91081598550184,Inf,0.0296198560706035,"lineage4","dr_mutations_pyrazinamide","ASP",0,"ERR1213950","ERR1213950","lineage4.1.1.1","bd","Bangladesh","pnca_p.gly105asp","A","G","GLY","GA105","pnca_complex.pdb"
|
|
"G105D","L4","PZA","G","G105",105,"D",1,"Pre-MDR","DM","hydrophobic","hydrophilic","neutral","acidic","non-polar","neg",7.858,0.709,-1.651,2.15123,-2.29,-1.54,79,85,-0.506,7,7,0,0,"helix",0.533333333333333,7.04,0.0001437401178668,19.411022297013,511754.463553489,Inf,4.73122070382274,-20,-32,0,0,-32,0,0,0,0,-2,0,2,-2,0,0,0,0,-5,0,0,-5,-18,0,-15,-25,0.317937219730942,-0.426614987080103,0.0783524792575703,-0.390451832907076,-0.403141361256544,0.831578947368421,-0.416803953871499,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.674,-0.411,"7:7","150/150","A:S:M:G:I:V:L",13.1456002256223,0.924803768447052,139.277183326685,0.0943844491368573,0.0001628371344425,NA,1.28804840845689,0.0292235860951597,1.53426649183163,0.91081598550184,Inf,0.0296198560706035,"lineage4","dr_mutations_pyrazinamide","ASP",0,"ERR2516440","ERR2516440","lineage4.1.2.1","pe","Peru","pnca_p.gly105asp","A","G","GLY","GA105","pnca_complex.pdb"
|
|
"G105R","L2","PZA","G","G105",105,"R",1,"Pre-XDR","DM","hydrophobic","hydrophilic","neutral","basic","non-polar","pos",7.858,-0.634,-0.974,5.20362,-1.727,-0.66,81,91,-0.506,7,7,0,0,"helix",0.533333333333333,7.04,7.18700589334483e-05,9.70142977291842,188179.926264685,Inf,0.763784339928386,-98,-50,0,-2,-48,0,0,0,0,-4,0,0,-4,0,0,0,0,-23,0,-8,-21,-22,0,-27,-39,-0.160587639311044,-0.251679586563308,0.189527167301627,-0.294458653026428,-0.172774869109948,0.852631578947368,-0.416803953871499,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.674,-0.411,"7:7","150/150","A:S:M:G:I:V:L",12.1451538387267,0.919026337424243,119.468044436248,0.101660271548245,5.01153666061226e-06,NA,0.986835744238421,0.170978870202674,0.767057556984365,0.124324963210678,Inf,0.382146811758261,"lineage2","dr_mutations_pyrazinamide","ARG",0,"ERR2516270","ERR2516270","lineage2.2.1","be","Belgium","pnca_p.gly105arg","A","G","GLY","GA105","pnca_complex.pdb"
|
|
"G105V","L2","PZA","G","G105",105,"V",1,"Pre-XDR","DM","hydrophobic","hydrophobic","neutral","non-polar","non-polar","non-polar",7.858,-0.85,0.117,-2.03856,-1.183,-0.86,68,80,-0.506,7,7,0,0,"helix",0.533333333333333,7.04,7.18700589334483e-05,9.70142977291842,188179.926264631,Inf,0.763784339928386,-2,0,0,0,0,0,0,0,0,-2,0,-2,2,0,0,0,0,-9,0,-1,-10,-8,0,-9,-21,-0.215298885511651,0.0994897959183673,-0.391940321464277,-0.201705029838022,-0.225130890052356,0.715789473684211,-0.416803953871499,"Destabilising","Stabilising","Stabilising","Destabilising","Destabilising","effect",-0.674,-0.411,"7:7","150/150","A:S:M:G:I:V:L",12.1451538387264,0.919026337424233,119.468044436231,0.101660271548256,5.01153666062796e-06,NA,0.986835744238421,0.170978870202674,0.767057556984365,0.124324963210678,Inf,0.382146811758261,"lineage2","dr_mutations_pyrazinamide","VAL",0,"ERR2510727","ERR2510727","lineage2.2.1","it","Italy","pnca_p.gly105val","A","G","GLY","GA105","pnca_complex.pdb"
|
|
"G105V","L2","PZA","G","G105",105,"V",NA,"MDR","DM","hydrophobic","hydrophobic","neutral","non-polar","non-polar","non-polar",7.858,-0.85,0.117,-2.03856,-1.183,-0.86,68,80,-0.506,7,7,0,0,"helix",0.533333333333333,7.04,7.18700589334483e-05,9.70142977291842,188179.926264631,Inf,0.763784339928386,-2,0,0,0,0,0,0,0,0,-2,0,-2,2,0,0,0,0,-9,0,-1,-10,-8,0,-9,-21,-0.215298885511651,0.0994897959183673,-0.391940321464277,-0.201705029838022,-0.225130890052356,0.715789473684211,-0.416803953871499,"Destabilising","Stabilising","Stabilising","Destabilising","Destabilising","effect",-0.674,-0.411,"7:7","150/150","A:S:M:G:I:V:L",12.1451538387264,0.919026337424233,119.468044436231,0.101660271548256,5.01153666062796e-06,NA,0.986835744238421,0.170978870202674,0.767057556984365,0.124324963210678,Inf,0.382146811758261,"lineage2","dr_mutations_pyrazinamide","VAL",0,"SRR671806,BGI_SH166","SRR671806","lineage2.2.1","cn","China","pnca_p.gly105val","A","G","GLY","GA105","pnca_complex.pdb"
|
|
"G105V","L2","PZA","G","G105",105,"V",NA,"MDR","DM","hydrophobic","hydrophobic","neutral","non-polar","non-polar","non-polar",7.858,-0.85,0.117,-2.03856,-1.183,-0.86,68,80,-0.506,7,7,0,0,"helix",0.533333333333333,7.04,7.18700589334483e-05,9.70142977291842,188179.926264631,Inf,0.763784339928386,-2,0,0,0,0,0,0,0,0,-2,0,-2,2,0,0,0,0,-9,0,-1,-10,-8,0,-9,-21,-0.215298885511651,0.0994897959183673,-0.391940321464277,-0.201705029838022,-0.225130890052356,0.715789473684211,-0.416803953871499,"Destabilising","Stabilising","Stabilising","Destabilising","Destabilising","effect",-0.674,-0.411,"7:7","150/150","A:S:M:G:I:V:L",12.1451538387264,0.919026337424233,119.468044436231,0.101660271548256,5.01153666062796e-06,NA,0.986835744238421,0.170978870202674,0.767057556984365,0.124324963210678,Inf,0.382146811758261,"lineage2","dr_mutations_pyrazinamide","VAL",0,"ETB0087","SRR6257029","lineage2.2.1","ru","Russia:Irkutsk Region","pnca_p.gly105val","A","G","GLY","GA105","pnca_complex.pdb"
|
|
"F106C","L4","PZA","F","F106",106,"C",0,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",10.466,-1.068,-1.594,3.977,-1.577,-2.12,59,75,-1.174,9,9,29,0.120833333333333,"helix",-0.366666666666667,5.05,7.18700589334483e-05,2.42412778478352,0.0001249735077034,0,1.03410070803344e-29,30,-2,0,0,-2,0,0,0,0,0,0,-2,-2,0,0,0,0,8,0,7,2,10,0,2,12,-0.270516717325228,-0.411886304909561,0.144850996874977,-0.268883205456095,-0.554973821989529,0.621052631578947,-0.967051070840198,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","150/150","F:L",-8.98740878149641,0.940032862253633,119.468044435491,-0.0752285585987749,NA,4692673.51081193,0.384555509373631,1,0,0,188.544222231268,0.999999999999997,"lineage4","other_mutations_pyrazinamide","CYS",0,"SAMN10961321","SRR8651642","lineage4.5","cn","China:Wenzhou","pnca_p.phe106cys","A","G","PHE","FA106","pnca_complex.pdb"
|
|
"F106L","L1","PZA","F","F106",106,"L",0,"Sensitive","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",10.466,-1.708,-1.425,1.92858,-0.947,-1.96,66,80,-1.174,9,9,29,0.120833333333333,"helix",-0.366666666666667,5.05,0.0002156101768003,2.42493692178301,2.42493957425811,2.42473736947533,4.31445715363782e-25,10,4,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,2,0,0,2,6,0,2,4,-0.432624113475177,-0.368217054263566,0.0702430816075292,-0.161466325660699,-0.513089005235602,0.694736842105263,-0.967051070840198,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","150/150","F:L",0.885806606247283,0.469406216824826,1.22442753211922,0.723445514749363,0.112662937620387,25.3270547471038,0.384700446081433,0.430258985168156,0.366270051463612,0.0410854444106247,46.5881472867033,0.999999999999476,"lineage1","other_mutations_pyrazinamide","LEU",0,"ERR176618","ERR176618","lineage1.1.2","mw","Malawi","pnca_p.phe106leu","A","G","PHE","FA106","pnca_complex.pdb"
|
|
"F106L","L1;L4","PZA","F","F106",106,"L",0,"Sensitive","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",10.466,-1.708,-1.425,1.92858,-0.947,-1.96,66,80,-1.174,9,9,29,0.120833333333333,"helix",-0.366666666666667,5.05,0.0002156101768003,2.42493692178301,2.42493957425811,2.42473736947533,4.31445715363782e-25,10,4,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,2,0,0,2,6,0,2,4,-0.432624113475177,-0.368217054263566,0.0702430816075292,-0.161466325660699,-0.513089005235602,0.694736842105263,-0.967051070840198,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","150/150","F:L",0.885806606247283,0.469406216824826,1.22442753211922,0.723445514749363,0.112662937620387,25.3270547471038,0.384700446081433,0.430258985168156,0.366270051463612,0.0410854444106247,46.5881472867033,0.999999999999476,"lineage1;lineage4","other_mutations_pyrazinamide","LEU",0,"ERR2513014","ERR2513014","lineage4.1.2.1;lineage1.1.2","gb","UK","pnca_p.phe106leu","A","G","PHE","FA106","pnca_complex.pdb"
|
|
"F106L","L2","PZA","F","F106",106,"L",NA,"MDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",10.466,-1.708,-1.425,1.92858,-0.947,-1.96,66,80,-1.174,9,9,29,0.120833333333333,"helix",-0.366666666666667,5.05,0.0002156101768003,2.42493692178301,2.42493957425811,2.42473736947533,4.31445715363782e-25,10,4,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,2,0,0,2,6,0,2,4,-0.432624113475177,-0.368217054263566,0.0702430816075292,-0.161466325660699,-0.513089005235602,0.694736842105263,-0.967051070840198,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","150/150","F:L",0.885806606247283,0.469406216824826,1.22442753211922,0.723445514749363,0.112662937620387,25.3270547471038,0.384700446081433,0.430258985168156,0.366270051463612,0.0410854444106247,46.5881472867033,0.999999999999476,"lineage2","other_mutations_pyrazinamide","LEU",0,"SRR7517806","SRR7517806","lineage2.2.1","ch","Switzerland","pnca_p.phe106leu","A","G","PHE","FA106","pnca_complex.pdb"
|
|
"F106L","L1","PZA","F","F106",106,"L",NA,"MDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",10.466,-1.708,-1.425,1.92858,-0.947,-1.96,66,80,-1.174,9,9,29,0.120833333333333,"helix",-0.366666666666667,5.05,0.0002156101768003,2.42493692178301,2.42493957425811,2.42473736947533,4.31445715363782e-25,10,4,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,2,0,0,2,6,0,2,4,-0.432624113475177,-0.368217054263566,0.0702430816075292,-0.161466325660699,-0.513089005235602,0.694736842105263,-0.967051070840198,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","150/150","F:L",0.885806606247283,0.469406216824826,1.22442753211922,0.723445514749363,0.112662937620387,25.3270547471038,0.384700446081433,0.430258985168156,0.366270051463612,0.0410854444106247,46.5881472867033,0.999999999999476,"lineage1","other_mutations_pyrazinamide","LEU",0,"SAMN02381004","SRR1062894_SRR1140718_SRR1049613_SRR1049612","lineage1.1.2","ug","Uganda","pnca_p.phe106leu","A","G","PHE","FA106","pnca_complex.pdb"
|
|
"F106L","L2","PZA","F","F106",106,"L",1,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",10.466,-1.708,-1.425,1.92858,-0.947,-1.96,66,80,-1.174,9,9,29,0.120833333333333,"helix",-0.366666666666667,5.05,0.0002156101768003,2.42493692178301,2.42493957425811,2.42473736947533,4.31445715363782e-25,10,4,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,2,0,0,2,6,0,2,4,-0.432624113475177,-0.368217054263566,0.0702430816075292,-0.161466325660699,-0.513089005235602,0.694736842105263,-0.967051070840198,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","150/150","F:L",0.885806606247283,0.469406216824826,1.22442753211922,0.723445514749363,0.112662937620387,25.3270547471038,0.384700446081433,0.430258985168156,0.366270051463612,0.0410854444106247,46.5881472867033,0.999999999999476,"lineage2","other_mutations_pyrazinamide","LEU",0,"SAMEA2533484,ERS456886","ERR550806_ERR550807","lineage2.2.1","uz","Nukus","pnca_p.phe106leu","A","G","PHE","FA106","pnca_complex.pdb"
|
|
"F106L","L2","PZA","F","F106",106,"L",NA,"XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",10.466,-1.708,-1.425,1.92858,-0.947,-1.96,66,80,-1.174,9,9,29,0.120833333333333,"helix",-0.366666666666667,5.05,0.0002156101768003,2.42493692178301,2.42493957425811,2.42473736947533,4.31445715363782e-25,10,4,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,2,0,0,2,6,0,2,4,-0.432624113475177,-0.368217054263566,0.0702430816075292,-0.161466325660699,-0.513089005235602,0.694736842105263,-0.967051070840198,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","150/150","F:L",0.885806606247283,0.469406216824826,1.22442753211922,0.723445514749363,0.112662937620387,25.3270547471038,0.384700446081433,0.430258985168156,0.366270051463612,0.0410854444106247,46.5881472867033,0.999999999999476,"lineage2","other_mutations_pyrazinamide","LEU",0,"SAMN03653316,SRS935944","SRR2024899","lineage2.2.1","cn","China","pnca_p.phe106leu","A","G","PHE","FA106","pnca_complex.pdb"
|
|
"F106S","L4","PZA","F","F106",106,"S",1,"Pre-XDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",10.466,-0.439,-2.455,4.86398,-1.914,-2.08,73,85,-1.174,9,9,29,0.120833333333333,"helix",-0.366666666666667,5.05,7.18700589334483e-05,9.70142977291842,188179.926264447,Inf,0.763784339928386,32,2,0,0,2,0,0,0,0,-2,0,-2,-4,0,0,0,0,8,0,4,5,6,0,-2,6,-0.111195542046606,-0.634366925064599,0.177156739195361,-0.326342710997442,-0.544502617801047,0.768421052631579,-0.967051070840198,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","150/150","F:L",12.1451538387255,0.9190263374242,119.468044436172,0.101660271548299,5.01153666068353e-06,NA,0.986835744238421,0.170978870202674,0.767057556984365,0.124324963210678,Inf,0.382146811758261,"lineage4","dr_mutations_pyrazinamide","SER",0,"ERR2041728","ERR2041728","lineage4.1.2.1","rs","Serbia","pnca_p.phe106ser","A","G","PHE","FA106","pnca_complex.pdb"
|
|
"F106V","L2","PZA","F","F106",106,"V",NA,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",10.466,-1.625,-1.933,3.73767,-2.02,-2.1,69,80,-1.174,9,9,29,0.120833333333333,"helix",-0.366666666666667,5.05,7.18700589334483e-05,9.70142977291842,188179.926264574,Inf,0.763784339928386,30,4,0,0,4,0,0,0,0,0,0,-2,0,0,0,0,0,6,0,4,3,10,0,2,8,-0.411600810536981,-0.499483204134367,0.136134077316997,-0.344416027280477,-0.549738219895288,0.726315789473684,-0.967051070840198,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","150/150","F:L",12.1451538387261,0.919026337424223,119.468044436213,0.101660271548269,5.01153666064512e-06,NA,0.986835744238421,0.170978870202674,0.767057556984365,0.124324963210678,Inf,0.382146811758261,"lineage2","other_mutations_pyrazinamide","VAL",0,"ERR751650","ERR751650","lineage2.2.1","th","Thailand","pnca_p.phe106val","A","G","PHE","FA106","pnca_complex.pdb"
|
|
"F106V","L2","PZA","F","F106",106,"V",1,"Pre-MDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",10.466,-1.625,-1.933,3.73767,-2.02,-2.1,69,80,-1.174,9,9,29,0.120833333333333,"helix",-0.366666666666667,5.05,7.18700589334483e-05,9.70142977291842,188179.926264574,Inf,0.763784339928386,30,4,0,0,4,0,0,0,0,0,0,-2,0,0,0,0,0,6,0,4,3,10,0,2,8,-0.411600810536981,-0.499483204134367,0.136134077316997,-0.344416027280477,-0.549738219895288,0.726315789473684,-0.967051070840198,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","150/150","F:L",12.1451538387261,0.919026337424223,119.468044436213,0.101660271548269,5.01153666064512e-06,NA,0.986835744238421,0.170978870202674,0.767057556984365,0.124324963210678,Inf,0.382146811758261,"lineage2","other_mutations_pyrazinamide","VAL",0,"ERS456948","ERR550893_ERR550892","lineage2.2.1","uz","Nukus","pnca_p.phe106val","A","G","PHE","FA106","pnca_complex.pdb"
|
|
"E107D","L4","PZA","E","E107",107,"D",NA,"Other","OM","hydrophilic","hydrophilic","acidic","acidic","neg","neg",8.13,-0.656,-0.224,0.965668,-0.917,-0.02,7,53,-0.068,5,5,88,0.394618834080717,"helix",-0.366666666666667,3.69,NA,NA,NA,NA,NA,14,0,0,0,0,0,0,0,0,-2,0,-2,0,0,0,0,0,3,0,-1,4,-6,0,-4,-4,-0.166160081053698,-0.0578811369509043,0.0351717305633054,-0.156351236146633,-0.0052356020942408,0.0736842105263158,-0.0560131795716639,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.244,0.083,"6:5","150/150","T:S:G:A:M:D:Q:F:H:Y:E:R:V:L",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage4","other_mutations_pyrazinamide","ASP",0,"SRR5065629","SRR5065629","lineage4.1.2.1","vn","Vietnam","pnca_p.glu107asp","A","G","GLU","EA107","pnca_complex.pdb"
|
|
"G108E","L2","PZA","G","G108",108,"E",NA,"XDR","OM","hydrophobic","hydrophilic","neutral","acidic","non-polar","neg",10.939,0.303,-1.423,3.72313,-3.566,-0.78,39,66,-0.947,9,9,0,0,"loop",0.1,5.18,NA,NA,NA,NA,NA,-44,-66,0,0,-66,0,0,0,0,-2,0,-2,0,0,0,0,0,-13,0,-8,-9,-12,0,-15,-23,0.135874439461883,-0.367700258397933,0.13560449886727,-0.608013640238704,-0.204188481675393,0.410526315789474,-0.78006589785832,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.062,-0.872,"9:8","136/150","N:V:D:G:E:A:P",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage2","other_mutations_pyrazinamide","GLU",0,"ERR067605,0224V-sc-2011-09-07T13:19:04Z-1276452","ERR067605","lineage2.2.1","ru","Russia","pnca_p.gly108glu","A","-","GLY","GA108","pnca_complex.pdb"
|
|
"G108R","","PZA","G","G108",108,"R",NA,"MDR","DM","hydrophobic","hydrophilic","neutral","basic","non-polar","pos",10.939,-1.199,-0.972,8.65723,-2.025,-0.81,53,75,-0.947,9,9,0,0,"loop",0.1,5.18,0.0002874802357337,4.85191417753471,4.85191414039983,4.85118443551178,1.17497090855698,-90,-46,0,0,-46,0,0,0,0,-4,0,-2,0,0,0,0,0,-22,0,-10,-18,-18,0,-17,-31,-0.303698074974671,-0.251162790697674,0.315315161095288,-0.345268542199488,-0.212041884816754,0.557894736842105,-0.78006589785832,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.062,-0.872,"9:8","136/150","N:V:D:G:E:A:P",1.57937329521209,0.114342297004303,1.0002536454007,1.57897279602454,0.581889091312071,40.456291107579,0.685913110299906,0.137954936368295,0.860262754777729,0.351471331417763,67.0421060419706,0.278382201819561,"","dr_mutations_pyrazinamide","ARG",0,"SRR5818423","SRR5818423","","dj","Djibouti","pnca_p.gly108arg","A","-","GLY","GA108","pnca_complex.pdb"
|
|
"G108R","L3","PZA","G","G108",108,"R",1,"MDR","DM","hydrophobic","hydrophilic","neutral","basic","non-polar","pos",10.939,-1.199,-0.972,8.65723,-2.025,-0.81,53,75,-0.947,9,9,0,0,"loop",0.1,5.18,0.0002874802357337,4.85191417753471,4.85191414039983,4.85118443551178,1.17497090855698,-90,-46,0,0,-46,0,0,0,0,-4,0,-2,0,0,0,0,0,-22,0,-10,-18,-18,0,-17,-31,-0.303698074974671,-0.251162790697674,0.315315161095288,-0.345268542199488,-0.212041884816754,0.557894736842105,-0.78006589785832,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.062,-0.872,"9:8","136/150","N:V:D:G:E:A:P",1.57937329521209,0.114342297004303,1.0002536454007,1.57897279602454,0.581889091312071,40.456291107579,0.685913110299906,0.137954936368295,0.860262754777729,0.351471331417763,67.0421060419706,0.278382201819561,"lineage3","dr_mutations_pyrazinamide","ARG",0,"ERR2510425","ERR2510425","lineage3","pk","Pakistan","pnca_p.gly108arg","A","-","GLY","GA108","pnca_complex.pdb"
|
|
"G108R","L4","PZA","G","G108",108,"R",NA,"MDR","DM","hydrophobic","hydrophilic","neutral","basic","non-polar","pos",10.939,-1.199,-0.972,8.65723,-2.025,-0.81,53,75,-0.947,9,9,0,0,"loop",0.1,5.18,0.0002874802357337,4.85191417753471,4.85191414039983,4.85118443551178,1.17497090855698,-90,-46,0,0,-46,0,0,0,0,-4,0,-2,0,0,0,0,0,-22,0,-10,-18,-18,0,-17,-31,-0.303698074974671,-0.251162790697674,0.315315161095288,-0.345268542199488,-0.212041884816754,0.557894736842105,-0.78006589785832,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.062,-0.872,"9:8","136/150","N:V:D:G:E:A:P",1.57937329521209,0.114342297004303,1.0002536454007,1.57897279602454,0.581889091312071,40.456291107579,0.685913110299906,0.137954936368295,0.860262754777729,0.351471331417763,67.0421060419706,0.278382201819561,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERR1193724","ERR1193724","lineage4.3.4.2","ph","Philippines","pnca_p.gly108arg","A","-","GLY","GA108","pnca_complex.pdb"
|
|
"G108R","","PZA","G","G108",108,"R",NA,"MDR","DM","hydrophobic","hydrophilic","neutral","basic","non-polar","pos",10.939,-1.199,-0.972,8.65723,-2.025,-0.81,53,75,-0.947,9,9,0,0,"loop",0.1,5.18,0.0002874802357337,4.85191417753471,4.85191414039983,4.85118443551178,1.17497090855698,-90,-46,0,0,-46,0,0,0,0,-4,0,-2,0,0,0,0,0,-22,0,-10,-18,-18,0,-17,-31,-0.303698074974671,-0.251162790697674,0.315315161095288,-0.345268542199488,-0.212041884816754,0.557894736842105,-0.78006589785832,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.062,-0.872,"9:8","136/150","N:V:D:G:E:A:P",1.57937329521209,0.114342297004303,1.0002536454007,1.57897279602454,0.581889091312071,40.456291107579,0.685913110299906,0.137954936368295,0.860262754777729,0.351471331417763,67.0421060419706,0.278382201819561,"","dr_mutations_pyrazinamide","ARG",0,"SRR5818411","SRR5818411","","dj","Djibouti","pnca_p.gly108arg","A","-","GLY","GA108","pnca_complex.pdb"
|
|
"G108R","L4","PZA","G","G108",108,"R",NA,"MDR","DM","hydrophobic","hydrophilic","neutral","basic","non-polar","pos",10.939,-1.199,-0.972,8.65723,-2.025,-0.81,53,75,-0.947,9,9,0,0,"loop",0.1,5.18,0.0002874802357337,4.85191417753471,4.85191414039983,4.85118443551178,1.17497090855698,-90,-46,0,0,-46,0,0,0,0,-4,0,-2,0,0,0,0,0,-22,0,-10,-18,-18,0,-17,-31,-0.303698074974671,-0.251162790697674,0.315315161095288,-0.345268542199488,-0.212041884816754,0.557894736842105,-0.78006589785832,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.062,-0.872,"9:8","136/150","N:V:D:G:E:A:P",1.57937329521209,0.114342297004303,1.0002536454007,1.57897279602454,0.581889091312071,40.456291107579,0.685913110299906,0.137954936368295,0.860262754777729,0.351471331417763,67.0421060419706,0.278382201819561,"lineage4","dr_mutations_pyrazinamide","ARG",0,"SRR3724998","SRR3724998","lineage4.1","ci","Ivory_Coast","pnca_p.gly108arg","A","-","GLY","GA108","pnca_complex.pdb"
|
|
"G108R","L4","PZA","G","G108",108,"R",0,"MDR","DM","hydrophobic","hydrophilic","neutral","basic","non-polar","pos",10.939,-1.199,-0.972,8.65723,-2.025,-0.81,53,75,-0.947,9,9,0,0,"loop",0.1,5.18,0.0002874802357337,4.85191417753471,4.85191414039983,4.85118443551178,1.17497090855698,-90,-46,0,0,-46,0,0,0,0,-4,0,-2,0,0,0,0,0,-22,0,-10,-18,-18,0,-17,-31,-0.303698074974671,-0.251162790697674,0.315315161095288,-0.345268542199488,-0.212041884816754,0.557894736842105,-0.78006589785832,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.062,-0.872,"9:8","136/150","N:V:D:G:E:A:P",1.57937329521209,0.114342297004303,1.0002536454007,1.57897279602454,0.581889091312071,40.456291107579,0.685913110299906,0.137954936368295,0.860262754777729,0.351471331417763,67.0421060419706,0.278382201819561,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERR2516703","ERR2516703","lineage4.1.1","nl","Netherlands","pnca_p.gly108arg","A","-","GLY","GA108","pnca_complex.pdb"
|
|
"G108R","L4","PZA","G","G108",108,"R",NA,"MDR","DM","hydrophobic","hydrophilic","neutral","basic","non-polar","pos",10.939,-1.199,-0.972,8.65723,-2.025,-0.81,53,75,-0.947,9,9,0,0,"loop",0.1,5.18,0.0002874802357337,4.85191417753471,4.85191414039983,4.85118443551178,1.17497090855698,-90,-46,0,0,-46,0,0,0,0,-4,0,-2,0,0,0,0,0,-22,0,-10,-18,-18,0,-17,-31,-0.303698074974671,-0.251162790697674,0.315315161095288,-0.345268542199488,-0.212041884816754,0.557894736842105,-0.78006589785832,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.062,-0.872,"9:8","136/150","N:V:D:G:E:A:P",1.57937329521209,0.114342297004303,1.0002536454007,1.57897279602454,0.581889091312071,40.456291107579,0.685913110299906,0.137954936368295,0.860262754777729,0.351471331417763,67.0421060419706,0.278382201819561,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERR2707120","ERR2707120","lineage4.1.2","cd","Democratic Republic of Congo","pnca_p.gly108arg","A","-","GLY","GA108","pnca_complex.pdb"
|
|
"G108R","L3","PZA","G","G108",108,"R",1,"MDR","DM","hydrophobic","hydrophilic","neutral","basic","non-polar","pos",10.939,-1.199,-0.972,8.65723,-2.025,-0.81,53,75,-0.947,9,9,0,0,"loop",0.1,5.18,0.0002874802357337,4.85191417753471,4.85191414039983,4.85118443551178,1.17497090855698,-90,-46,0,0,-46,0,0,0,0,-4,0,-2,0,0,0,0,0,-22,0,-10,-18,-18,0,-17,-31,-0.303698074974671,-0.251162790697674,0.315315161095288,-0.345268542199488,-0.212041884816754,0.557894736842105,-0.78006589785832,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.062,-0.872,"9:8","136/150","N:V:D:G:E:A:P",1.57937329521209,0.114342297004303,1.0002536454007,1.57897279602454,0.581889091312071,40.456291107579,0.685913110299906,0.137954936368295,0.860262754777729,0.351471331417763,67.0421060419706,0.278382201819561,"lineage3","dr_mutations_pyrazinamide","ARG",0,"ERR2517123","ERR2517123","lineage3.1.2","gb","UK","pnca_p.gly108arg","A","-","GLY","GA108","pnca_complex.pdb"
|
|
"G108R","L3","PZA","G","G108",108,"R",0,"MDR","DM","hydrophobic","hydrophilic","neutral","basic","non-polar","pos",10.939,-1.199,-0.972,8.65723,-2.025,-0.81,53,75,-0.947,9,9,0,0,"loop",0.1,5.18,0.0002874802357337,4.85191417753471,4.85191414039983,4.85118443551178,1.17497090855698,-90,-46,0,0,-46,0,0,0,0,-4,0,-2,0,0,0,0,0,-22,0,-10,-18,-18,0,-17,-31,-0.303698074974671,-0.251162790697674,0.315315161095288,-0.345268542199488,-0.212041884816754,0.557894736842105,-0.78006589785832,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.062,-0.872,"9:8","136/150","N:V:D:G:E:A:P",1.57937329521209,0.114342297004303,1.0002536454007,1.57897279602454,0.581889091312071,40.456291107579,0.685913110299906,0.137954936368295,0.860262754777729,0.351471331417763,67.0421060419706,0.278382201819561,"lineage3","dr_mutations_pyrazinamide","ARG",0,"ERR2510376","ERR2510376","lineage3","pk","Pakistan","pnca_p.gly108arg","A","-","GLY","GA108","pnca_complex.pdb"
|
|
"D110H","L1","PZA","D","D110",110,"H",NA,"Sensitive","OM","hydrophilic","hydrophobic","acidic","basic","neg","pos",16.281,-1.3,-0.761,3.05477,-0.614,-0.26,-18,57,0.526,3,3,17,0.0880829015544041,"loop",-0.933333333333333,4.81,NA,NA,NA,NA,NA,-10,20,0,0,20,0,0,0,0,-2,0,0,0,0,0,0,0,-3,0,-3,-1,0,0,2,0,-0.329280648429585,-0.196640826873385,0.111261372824685,-0.104688832054561,-0.0680628272251308,-0.193548387096774,0.168589743589744,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","neutral",0.225,0.59,"4:3","128/150","Q:H:E:K:R:L:N:T:A:G:S:D",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage1","other_mutations_pyrazinamide","HIS",0,"ERR3256124","ERR3256124","lineage1.2.1","ph","Philippines","pnca_p.asp110his","A","-","ASP","DA110","pnca_complex.pdb"
|
|
"E111D","L3;L4","PZA","E","E111",111,"D",NA,"Pre-MDR","OM","hydrophilic","hydrophilic","acidic","acidic","neg","neg",18.382,0.103,0.156,0.183196,-0.053,-0.32,-55,78,1.616,1,1,167,0.748878923766816,"loop",-3.5,3.55,7.18700589334483e-05,2.42412778478352,0.0001249735077034,0,1.03410070803344e-29,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,1,0,0,0,0,0.0461883408071748,0.13265306122449,0.00667239708913963,-0.00903665814151748,-0.0837696335078534,-0.591397849462366,0.517948717948718,"Stabilising","Stabilising","Destabilising","Destabilising","Destabilising","neutral",1.183,1.712,"1:1","132/150","T:M:S:G:A:P:D:F:E:Q:L:V:N:R:K",-8.98740878149641,0.940032862253633,119.46804443549,-0.0752285585987759,NA,4692673.51081035,0.384555509373631,1,0,0,188.544222231268,0.999999999999997,"lineage3;lineage4","other_mutations_pyrazinamide","ASP",0,"SRR6325444","SRR6325444","lineage4.3;lineage3","us","","pnca_p.glu111asp","A","S","GLU","EA111","pnca_complex.pdb"
|
|
"E111D","L4","PZA","E","E111",111,"D",NA,"Pre-MDR","OM","hydrophilic","hydrophilic","acidic","acidic","neg","neg",18.382,0.103,0.156,0.183196,-0.053,-0.32,-55,78,1.616,1,1,167,0.748878923766816,"loop",-3.5,3.55,7.18700589334483e-05,2.42412778478352,0.0001249735077034,0,1.03410070803344e-29,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,1,0,0,0,0,0.0461883408071748,0.13265306122449,0.00667239708913963,-0.00903665814151748,-0.0837696335078534,-0.591397849462366,0.517948717948718,"Stabilising","Stabilising","Destabilising","Destabilising","Destabilising","neutral",1.183,1.712,"1:1","132/150","T:M:S:G:A:P:D:F:E:Q:L:V:N:R:K",-8.98740878149641,0.940032862253633,119.46804443549,-0.0752285585987759,NA,4692673.51081035,0.384555509373631,1,0,0,188.544222231268,0.999999999999997,"lineage4","other_mutations_pyrazinamide","ASP",0,"SRR6325448","SRR6325448","lineage4.3","us","","pnca_p.glu111asp","A","S","GLU","EA111","pnca_complex.pdb"
|
|
"E111D","","PZA","E","E111",111,"D",0,"Pre-MDR","OM","hydrophilic","hydrophilic","acidic","acidic","neg","neg",18.382,0.103,0.156,0.183196,-0.053,-0.32,-55,78,1.616,1,1,167,0.748878923766816,"loop",-3.5,3.55,7.18700589334483e-05,2.42412778478352,0.0001249735077034,0,1.03410070803344e-29,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,1,0,0,0,0,0.0461883408071748,0.13265306122449,0.00667239708913963,-0.00903665814151748,-0.0837696335078534,-0.591397849462366,0.517948717948718,"Stabilising","Stabilising","Destabilising","Destabilising","Destabilising","neutral",1.183,1.712,"1:1","132/150","T:M:S:G:A:P:D:F:E:Q:L:V:N:R:K",-8.98740878149641,0.940032862253633,119.46804443549,-0.0752285585987759,NA,4692673.51081035,0.384555509373631,1,0,0,188.544222231268,0.999999999999997,"","other_mutations_pyrazinamide","ASP",0,"ERR1035239","ERR1035239","","pt","Portugal","pnca_p.glu111asp","A","S","GLU","EA111","pnca_complex.pdb"
|
|
"E111D","L4","PZA","E","E111",111,"D",NA,"Pre-MDR","OM","hydrophilic","hydrophilic","acidic","acidic","neg","neg",18.382,0.103,0.156,0.183196,-0.053,-0.32,-55,78,1.616,1,1,167,0.748878923766816,"loop",-3.5,3.55,7.18700589334483e-05,2.42412778478352,0.0001249735077034,0,1.03410070803344e-29,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,1,0,0,0,0,0.0461883408071748,0.13265306122449,0.00667239708913963,-0.00903665814151748,-0.0837696335078534,-0.591397849462366,0.517948717948718,"Stabilising","Stabilising","Destabilising","Destabilising","Destabilising","neutral",1.183,1.712,"1:1","132/150","T:M:S:G:A:P:D:F:E:Q:L:V:N:R:K",-8.98740878149641,0.940032862253633,119.46804443549,-0.0752285585987759,NA,4692673.51081035,0.384555509373631,1,0,0,188.544222231268,0.999999999999997,"lineage4","other_mutations_pyrazinamide","ASP",0,"SRR6325445","SRR6325445","lineage4.3","us","","pnca_p.glu111asp","A","S","GLU","EA111","pnca_complex.pdb"
|
|
"N112Y","L1","PZA","N","N112",112,"Y",NA,"Sensitive","OM","hydrophilic","hydrophobic","neutral","neutral","polar","polar",19.93,-0.261,-0.378,4.97901,-0.297,-0.25,26,63,0.77,2,2,109,0.558974358974359,"loop",-2.46666666666667,3.54,NA,NA,NA,NA,NA,-10,2,0,0,2,0,0,0,0,2,0,2,4,0,0,0,0,0,0,2,1,4,0,0,4,-0.0661094224924012,-0.0976744186046511,0.181346382185185,-0.0506393861892583,-0.0654450261780104,0.273684210526316,0.246794871794872,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.389,0.842,"4:2","131/150","K:R:N:V:Q:E:H:D:P:S:M:G:A:T",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage1","other_mutations_pyrazinamide","TYR",0,"SRR6152963","SRR6152963","lineage1.2.1","ca","Canada","pnca_p.asn112tyr","A","S","ASN","NA112","pnca_complex.pdb"
|
|
"T114M","L2","PZA","T","T114",114,"M",NA,"Sensitive","OM","hydrophobic","hydrophobic","neutral","non-polar","polar","non-polar",17.491,-1.152,0.246,-0.0405939,-0.077,0.38,25,63,-0.224,6,6,29,0.168604651162791,"loop",-0.9,4.57,7.18700589334483e-05,2.42412778478352,0.0001249735077034,0,1.03410070803344e-29,-8,0,0,0,0,0,0,0,0,-2,0,-2,2,0,0,0,0,-6,0,0,-6,0,0,0,2,-0.291793313069909,0.209183673469388,-0.00780471814196724,-0.0131287297527707,0.213483146067416,0.263157894736842,-0.184514003294893,"Destabilising","Stabilising","Stabilising","Destabilising","Stabilising","effect",-0.411,-0.147,"7:6","148/150","S:A:P:D:H:K:T:W:E:Q:V:N:L:I:R:C",-8.98740878149641,0.940032862253633,119.468044435491,-0.0752285585987751,NA,4692673.51081327,0.384555509373631,1,0,0,188.544222231268,0.999999999999997,"lineage2","other_mutations_pyrazinamide","MET",0,"ERR1034985","ERR1034985","lineage2.2.1.1","za","South Africa","pnca_p.thr114met","A","-","THR","TA114","pnca_complex.pdb"
|
|
"T114M","L2","PZA","T","T114",114,"M",NA,"Pre-XDR","OM","hydrophobic","hydrophobic","neutral","non-polar","polar","non-polar",17.491,-1.152,0.246,-0.0405939,-0.077,0.38,25,63,-0.224,6,6,29,0.168604651162791,"loop",-0.9,4.57,7.18700589334483e-05,2.42412778478352,0.0001249735077034,0,1.03410070803344e-29,-8,0,0,0,0,0,0,0,0,-2,0,-2,2,0,0,0,0,-6,0,0,-6,0,0,0,2,-0.291793313069909,0.209183673469388,-0.00780471814196724,-0.0131287297527707,0.213483146067416,0.263157894736842,-0.184514003294893,"Destabilising","Stabilising","Stabilising","Destabilising","Stabilising","effect",-0.411,-0.147,"7:6","148/150","S:A:P:D:H:K:T:W:E:Q:V:N:L:I:R:C",-8.98740878149641,0.940032862253633,119.468044435491,-0.0752285585987751,NA,4692673.51081327,0.384555509373631,1,0,0,188.544222231268,0.999999999999997,"lineage2","other_mutations_pyrazinamide","MET",0,"ERR1035073","ERR1035073","lineage2.2.1.1","za","South Africa","pnca_p.thr114met","A","-","THR","TA114","pnca_complex.pdb"
|
|
"T114M","L2","PZA","T","T114",114,"M",NA,"Sensitive","OM","hydrophobic","hydrophobic","neutral","non-polar","polar","non-polar",17.491,-1.152,0.246,-0.0405939,-0.077,0.38,25,63,-0.224,6,6,29,0.168604651162791,"loop",-0.9,4.57,7.18700589334483e-05,2.42412778478352,0.0001249735077034,0,1.03410070803344e-29,-8,0,0,0,0,0,0,0,0,-2,0,-2,2,0,0,0,0,-6,0,0,-6,0,0,0,2,-0.291793313069909,0.209183673469388,-0.00780471814196724,-0.0131287297527707,0.213483146067416,0.263157894736842,-0.184514003294893,"Destabilising","Stabilising","Stabilising","Destabilising","Stabilising","effect",-0.411,-0.147,"7:6","148/150","S:A:P:D:H:K:T:W:E:Q:V:N:L:I:R:C",-8.98740878149641,0.940032862253633,119.468044435491,-0.0752285585987751,NA,4692673.51081327,0.384555509373631,1,0,0,188.544222231268,0.999999999999997,"lineage2","other_mutations_pyrazinamide","MET",0,"022-1","ERR1750915","lineage2.2.1.1","za","","pnca_p.thr114met","A","-","THR","TA114","pnca_complex.pdb"
|
|
"T114M","L2","PZA","T","T114",114,"M",NA,"Sensitive","OM","hydrophobic","hydrophobic","neutral","non-polar","polar","non-polar",17.491,-1.152,0.246,-0.0405939,-0.077,0.38,25,63,-0.224,6,6,29,0.168604651162791,"loop",-0.9,4.57,7.18700589334483e-05,2.42412778478352,0.0001249735077034,0,1.03410070803344e-29,-8,0,0,0,0,0,0,0,0,-2,0,-2,2,0,0,0,0,-6,0,0,-6,0,0,0,2,-0.291793313069909,0.209183673469388,-0.00780471814196724,-0.0131287297527707,0.213483146067416,0.263157894736842,-0.184514003294893,"Destabilising","Stabilising","Stabilising","Destabilising","Stabilising","effect",-0.411,-0.147,"7:6","148/150","S:A:P:D:H:K:T:W:E:Q:V:N:L:I:R:C",-8.98740878149641,0.940032862253633,119.468044435491,-0.0752285585987751,NA,4692673.51081327,0.384555509373631,1,0,0,188.544222231268,0.999999999999997,"lineage2","other_mutations_pyrazinamide","MET",0,"ERS3466716","ERR3340744","lineage2.2.1.1","za","","pnca_p.thr114met","A","-","THR","TA114","pnca_complex.pdb"
|
|
"T114M","L2","PZA","T","T114",114,"M",NA,"Sensitive","OM","hydrophobic","hydrophobic","neutral","non-polar","polar","non-polar",17.491,-1.152,0.246,-0.0405939,-0.077,0.38,25,63,-0.224,6,6,29,0.168604651162791,"loop",-0.9,4.57,7.18700589334483e-05,2.42412778478352,0.0001249735077034,0,1.03410070803344e-29,-8,0,0,0,0,0,0,0,0,-2,0,-2,2,0,0,0,0,-6,0,0,-6,0,0,0,2,-0.291793313069909,0.209183673469388,-0.00780471814196724,-0.0131287297527707,0.213483146067416,0.263157894736842,-0.184514003294893,"Destabilising","Stabilising","Stabilising","Destabilising","Stabilising","effect",-0.411,-0.147,"7:6","148/150","S:A:P:D:H:K:T:W:E:Q:V:N:L:I:R:C",-8.98740878149641,0.940032862253633,119.468044435491,-0.0752285585987751,NA,4692673.51081327,0.384555509373631,1,0,0,188.544222231268,0.999999999999997,"lineage2","other_mutations_pyrazinamide","MET",0,"ERS3466710","ERR3340738","lineage2.2.1.1","za","","pnca_p.thr114met","A","-","THR","TA114","pnca_complex.pdb"
|
|
"T114M","L2","PZA","T","T114",114,"M",NA,"Sensitive","OM","hydrophobic","hydrophobic","neutral","non-polar","polar","non-polar",17.491,-1.152,0.246,-0.0405939,-0.077,0.38,25,63,-0.224,6,6,29,0.168604651162791,"loop",-0.9,4.57,7.18700589334483e-05,2.42412778478352,0.0001249735077034,0,1.03410070803344e-29,-8,0,0,0,0,0,0,0,0,-2,0,-2,2,0,0,0,0,-6,0,0,-6,0,0,0,2,-0.291793313069909,0.209183673469388,-0.00780471814196724,-0.0131287297527707,0.213483146067416,0.263157894736842,-0.184514003294893,"Destabilising","Stabilising","Stabilising","Destabilising","Stabilising","effect",-0.411,-0.147,"7:6","148/150","S:A:P:D:H:K:T:W:E:Q:V:N:L:I:R:C",-8.98740878149641,0.940032862253633,119.468044435491,-0.0752285585987751,NA,4692673.51081327,0.384555509373631,1,0,0,188.544222231268,0.999999999999997,"lineage2","other_mutations_pyrazinamide","MET",0,"022-2","ERR1750916","lineage2.2.1.1","za","","pnca_p.thr114met","A","-","THR","TA114","pnca_complex.pdb"
|
|
"T114M","L2","PZA","T","T114",114,"M",NA,"Pre-MDR","OM","hydrophobic","hydrophobic","neutral","non-polar","polar","non-polar",17.491,-1.152,0.246,-0.0405939,-0.077,0.38,25,63,-0.224,6,6,29,0.168604651162791,"loop",-0.9,4.57,7.18700589334483e-05,2.42412778478352,0.0001249735077034,0,1.03410070803344e-29,-8,0,0,0,0,0,0,0,0,-2,0,-2,2,0,0,0,0,-6,0,0,-6,0,0,0,2,-0.291793313069909,0.209183673469388,-0.00780471814196724,-0.0131287297527707,0.213483146067416,0.263157894736842,-0.184514003294893,"Destabilising","Stabilising","Stabilising","Destabilising","Stabilising","effect",-0.411,-0.147,"7:6","148/150","S:A:P:D:H:K:T:W:E:Q:V:N:L:I:R:C",-8.98740878149641,0.940032862253633,119.468044435491,-0.0752285585987751,NA,4692673.51081327,0.384555509373631,1,0,0,188.544222231268,0.999999999999997,"lineage2","other_mutations_pyrazinamide","MET",0,"ERR552806","ERR552806","lineage2.2.1.1","sz","Swaziland","pnca_p.thr114met","A","-","THR","TA114","pnca_complex.pdb"
|
|
"T114M","L2","PZA","T","T114",114,"M",0,"MDR","OM","hydrophobic","hydrophobic","neutral","non-polar","polar","non-polar",17.491,-1.152,0.246,-0.0405939,-0.077,0.38,25,63,-0.224,6,6,29,0.168604651162791,"loop",-0.9,4.57,7.18700589334483e-05,2.42412778478352,0.0001249735077034,0,1.03410070803344e-29,-8,0,0,0,0,0,0,0,0,-2,0,-2,2,0,0,0,0,-6,0,0,-6,0,0,0,2,-0.291793313069909,0.209183673469388,-0.00780471814196724,-0.0131287297527707,0.213483146067416,0.263157894736842,-0.184514003294893,"Destabilising","Stabilising","Stabilising","Destabilising","Stabilising","effect",-0.411,-0.147,"7:6","148/150","S:A:P:D:H:K:T:W:E:Q:V:N:L:I:R:C",-8.98740878149641,0.940032862253633,119.468044435491,-0.0752285585987751,NA,4692673.51081327,0.384555509373631,1,0,0,188.544222231268,0.999999999999997,"lineage2","other_mutations_pyrazinamide","MET",0,"SAMN03648717,SRR2101470","SRR2101470","lineage2.2.1.1","","","pnca_p.thr114met","A","-","THR","TA114","pnca_complex.pdb"
|
|
"T114P","L2","PZA","T","T114",114,"P",1,"Pre-XDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",17.491,-1.322,-0.651,5.39158,-2.268,-0.1,34,66,-0.224,6,6,29,0.168604651162791,"loop",-0.9,4.57,7.18700589334483e-05,9.70142977291842,188179.926264667,Inf,0.763784339928386,4,0,0,0,0,0,0,0,0,0,0,0,4,0,0,0,0,-2,2,-4,0,4,0,-2,6,-0.334853090172239,-0.168217054263566,0.196373079640732,-0.386700767263427,-0.0261780104712041,0.357894736842105,-0.184514003294893,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.411,-0.147,"7:6","148/150","S:A:P:D:H:K:T:W:E:Q:V:N:L:I:R:C",12.1451538387266,0.91902633742424,119.468044436242,0.101660271548248,5.01153666061746e-06,NA,0.986835744238421,0.170978870202674,0.767057556984365,0.124324963210678,Inf,0.382146811758261,"lineage2","dr_mutations_pyrazinamide","PRO",0,"ERS456781","ERR550668_ERR550667_ERR550669","lineage2.2.1","uz","Nukus","pnca_p.thr114pro","A","-","THR","TA114","pnca_complex.pdb"
|
|
"P115L","L2","PZA","P","P115",115,"L",0,"Sensitive","OM","hydrophilic","hydrophobic","non-polar","non-polar","non-polar","non-polar",16.985,-0.972,-0.448,0.979724,-0.8,-0.55,8,53,0.774,2,2,50,0.314465408805031,"strand",0.5,4.3,7.18700589334483e-05,2.42412778478352,0.0001249735077034,0,1.03410070803344e-29,-14,0,0,0,0,0,0,0,0,-2,0,-2,0,0,0,0,0,-8,0,-4,-5,-2,0,-2,0,-0.246200607902736,-0.115762273901809,0.0356836806794921,-0.136402387041773,-0.143979057591623,0.0842105263157895,0.248076923076923,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.389,0.842,"4:2","147/150","T:G:A:S:P:D:E:Q:L:N:K:R",-8.98740878149641,0.940032862253632,119.46804443549,-0.0752285585987761,NA,4692673.51081015,0.384555509373631,1,0,0,188.544222231268,0.999999999999997,"lineage2","other_mutations_pyrazinamide","LEU",0,"non-MDR_11204","SRR6824507","lineage2.2.1","cn","China: Jianggan District, Hangzhou City, Zhejiang Province","pnca_p.pro115leu","A","B","PRO","PA115","pnca_complex.pdb"
|
|
"L116P","L4","PZA","L","L116",116,"P",NA,"MDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",13.071,-1.504,-1.386,3.74372,-2.595,0.06,89,91,-0.924,8,8,0,0,"helix",2,6.86,0.0002156101768003,9.70466975178797,9.70465898653047,9.70194990589383,2.29168245016684,18,0,0,0,0,0,0,0,0,2,2,-2,0,0,0,0,0,-3,2,-3,-2,8,0,0,8,-0.380952380952381,-0.358139534883721,0.136354431486243,-0.442455242966752,0.0337078651685393,0.936842105263158,-0.761120263591433,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-1.028,-0.872,"9:8","147/150","I:V:L:M:A:T:F",2.27260607808816,0.0634455902260904,1.22442760158496,1.8560559033024,0.929172866365899,208.881603004966,0.986980761010679,0.0776844925942494,1.10966566656461,0.504888890842109,570.372842410328,0.130068862702538,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR2510202","ERR2510202","lineage4.3.4.2","pe","Peru","pnca_p.leu116pro","A","H","LEU","LA116","pnca_complex.pdb"
|
|
"L116P","L4","PZA","L","L116",116,"P",NA,"MDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",13.071,-1.504,-1.386,3.74372,-2.595,0.06,89,91,-0.924,8,8,0,0,"helix",2,6.86,0.0002156101768003,9.70466975178797,9.70465898653047,9.70194990589383,2.29168245016684,18,0,0,0,0,0,0,0,0,2,2,-2,0,0,0,0,0,-3,2,-3,-2,8,0,0,8,-0.380952380952381,-0.358139534883721,0.136354431486243,-0.442455242966752,0.0337078651685393,0.936842105263158,-0.761120263591433,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-1.028,-0.872,"9:8","147/150","I:V:L:M:A:T:F",2.27260607808816,0.0634455902260904,1.22442760158496,1.8560559033024,0.929172866365899,208.881603004966,0.986980761010679,0.0776844925942494,1.10966566656461,0.504888890842109,570.372842410328,0.130068862702538,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR751565","ERR751565","lineage4.3.4.2","pe","","pnca_p.leu116pro","A","H","LEU","LA116","pnca_complex.pdb"
|
|
"L116P","L4","PZA","L","L116",116,"P",NA,"MDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",13.071,-1.504,-1.386,3.74372,-2.595,0.06,89,91,-0.924,8,8,0,0,"helix",2,6.86,0.0002156101768003,9.70466975178797,9.70465898653047,9.70194990589383,2.29168245016684,18,0,0,0,0,0,0,0,0,2,2,-2,0,0,0,0,0,-3,2,-3,-2,8,0,0,8,-0.380952380952381,-0.358139534883721,0.136354431486243,-0.442455242966752,0.0337078651685393,0.936842105263158,-0.761120263591433,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-1.028,-0.872,"9:8","147/150","I:V:L:M:A:T:F",2.27260607808816,0.0634455902260904,1.22442760158496,1.8560559033024,0.929172866365899,208.881603004966,0.986980761010679,0.0776844925942494,1.10966566656461,0.504888890842109,570.372842410328,0.130068862702538,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR2510217","ERR2510217","lineage4.3.4.2","pe","Peru","pnca_p.leu116pro","A","H","LEU","LA116","pnca_complex.pdb"
|
|
"L116P","L4","PZA","L","L116",116,"P",NA,"MDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",13.071,-1.504,-1.386,3.74372,-2.595,0.06,89,91,-0.924,8,8,0,0,"helix",2,6.86,0.0002156101768003,9.70466975178797,9.70465898653047,9.70194990589383,2.29168245016684,18,0,0,0,0,0,0,0,0,2,2,-2,0,0,0,0,0,-3,2,-3,-2,8,0,0,8,-0.380952380952381,-0.358139534883721,0.136354431486243,-0.442455242966752,0.0337078651685393,0.936842105263158,-0.761120263591433,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-1.028,-0.872,"9:8","147/150","I:V:L:M:A:T:F",2.27260607808816,0.0634455902260904,1.22442760158496,1.8560559033024,0.929172866365899,208.881603004966,0.986980761010679,0.0776844925942494,1.10966566656461,0.504888890842109,570.372842410328,0.130068862702538,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR779885","ERR779885","lineage4.3.4.2","pe","","pnca_p.leu116pro","A","H","LEU","LA116","pnca_complex.pdb"
|
|
"L116P","L4","PZA","L","L116",116,"P",NA,"MDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",13.071,-1.504,-1.386,3.74372,-2.595,0.06,89,91,-0.924,8,8,0,0,"helix",2,6.86,0.0002156101768003,9.70466975178797,9.70465898653047,9.70194990589383,2.29168245016684,18,0,0,0,0,0,0,0,0,2,2,-2,0,0,0,0,0,-3,2,-3,-2,8,0,0,8,-0.380952380952381,-0.358139534883721,0.136354431486243,-0.442455242966752,0.0337078651685393,0.936842105263158,-0.761120263591433,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-1.028,-0.872,"9:8","147/150","I:V:L:M:A:T:F",2.27260607808816,0.0634455902260904,1.22442760158496,1.8560559033024,0.929172866365899,208.881603004966,0.986980761010679,0.0776844925942494,1.10966566656461,0.504888890842109,570.372842410328,0.130068862702538,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR751482","ERR751482","lineage4.3.4.2","pe","","pnca_p.leu116pro","A","H","LEU","LA116","pnca_complex.pdb"
|
|
"L116P","L3","PZA","L","L116",116,"P",0,"MDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",13.071,-1.504,-1.386,3.74372,-2.595,0.06,89,91,-0.924,8,8,0,0,"helix",2,6.86,0.0002156101768003,9.70466975178797,9.70465898653047,9.70194990589383,2.29168245016684,18,0,0,0,0,0,0,0,0,2,2,-2,0,0,0,0,0,-3,2,-3,-2,8,0,0,8,-0.380952380952381,-0.358139534883721,0.136354431486243,-0.442455242966752,0.0337078651685393,0.936842105263158,-0.761120263591433,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-1.028,-0.872,"9:8","147/150","I:V:L:M:A:T:F",2.27260607808816,0.0634455902260904,1.22442760158496,1.8560559033024,0.929172866365899,208.881603004966,0.986980761010679,0.0776844925942494,1.10966566656461,0.504888890842109,570.372842410328,0.130068862702538,"lineage3","dr_mutations_pyrazinamide","PRO",0,"ERR2516933","ERR2516933","lineage3","gb","UK","pnca_p.leu116pro","A","H","LEU","LA116","pnca_complex.pdb"
|
|
"L116P","L2","PZA","L","L116",116,"P",1,"Pre-XDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",13.071,-1.504,-1.386,3.74372,-2.595,0.06,89,91,-0.924,8,8,0,0,"helix",2,6.86,0.0002156101768003,9.70466975178797,9.70465898653047,9.70194990589383,2.29168245016684,18,0,0,0,0,0,0,0,0,2,2,-2,0,0,0,0,0,-3,2,-3,-2,8,0,0,8,-0.380952380952381,-0.358139534883721,0.136354431486243,-0.442455242966752,0.0337078651685393,0.936842105263158,-0.761120263591433,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-1.028,-0.872,"9:8","147/150","I:V:L:M:A:T:F",2.27260607808816,0.0634455902260904,1.22442760158496,1.8560559033024,0.929172866365899,208.881603004966,0.986980761010679,0.0776844925942494,1.10966566656461,0.504888890842109,570.372842410328,0.130068862702538,"lineage2","dr_mutations_pyrazinamide","PRO",0,"ERR2510848","ERR2510848","lineage2.2.1","it","Italy","pnca_p.leu116pro","A","H","LEU","LA116","pnca_complex.pdb"
|
|
"L116P","L4","PZA","L","L116",116,"P",NA,"MDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",13.071,-1.504,-1.386,3.74372,-2.595,0.06,89,91,-0.924,8,8,0,0,"helix",2,6.86,0.0002156101768003,9.70466975178797,9.70465898653047,9.70194990589383,2.29168245016684,18,0,0,0,0,0,0,0,0,2,2,-2,0,0,0,0,0,-3,2,-3,-2,8,0,0,8,-0.380952380952381,-0.358139534883721,0.136354431486243,-0.442455242966752,0.0337078651685393,0.936842105263158,-0.761120263591433,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-1.028,-0.872,"9:8","147/150","I:V:L:M:A:T:F",2.27260607808816,0.0634455902260904,1.22442760158496,1.8560559033024,0.929172866365899,208.881603004966,0.986980761010679,0.0776844925942494,1.10966566656461,0.504888890842109,570.372842410328,0.130068862702538,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR2510170","ERR2510170","lineage4.3.4.2","pe","Peru","pnca_p.leu116pro","A","H","LEU","LA116","pnca_complex.pdb"
|
|
"L116P","L4","PZA","L","L116",116,"P",NA,"MDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",13.071,-1.504,-1.386,3.74372,-2.595,0.06,89,91,-0.924,8,8,0,0,"helix",2,6.86,0.0002156101768003,9.70466975178797,9.70465898653047,9.70194990589383,2.29168245016684,18,0,0,0,0,0,0,0,0,2,2,-2,0,0,0,0,0,-3,2,-3,-2,8,0,0,8,-0.380952380952381,-0.358139534883721,0.136354431486243,-0.442455242966752,0.0337078651685393,0.936842105263158,-0.761120263591433,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-1.028,-0.872,"9:8","147/150","I:V:L:M:A:T:F",2.27260607808816,0.0634455902260904,1.22442760158496,1.8560559033024,0.929172866365899,208.881603004966,0.986980761010679,0.0776844925942494,1.10966566656461,0.504888890842109,570.372842410328,0.130068862702538,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR845937","ERR845937","lineage4.3.4.2","pe","","pnca_p.leu116pro","A","H","LEU","LA116","pnca_complex.pdb"
|
|
"L116P","L4","PZA","L","L116",116,"P",NA,"MDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",13.071,-1.504,-1.386,3.74372,-2.595,0.06,89,91,-0.924,8,8,0,0,"helix",2,6.86,0.0002156101768003,9.70466975178797,9.70465898653047,9.70194990589383,2.29168245016684,18,0,0,0,0,0,0,0,0,2,2,-2,0,0,0,0,0,-3,2,-3,-2,8,0,0,8,-0.380952380952381,-0.358139534883721,0.136354431486243,-0.442455242966752,0.0337078651685393,0.936842105263158,-0.761120263591433,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-1.028,-0.872,"9:8","147/150","I:V:L:M:A:T:F",2.27260607808816,0.0634455902260904,1.22442760158496,1.8560559033024,0.929172866365899,208.881603004966,0.986980761010679,0.0776844925942494,1.10966566656461,0.504888890842109,570.372842410328,0.130068862702538,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR751549","ERR751549","lineage4.3.4.2","pe","","pnca_p.leu116pro","A","H","LEU","LA116","pnca_complex.pdb"
|
|
"L116P","L4","PZA","L","L116",116,"P",NA,"MDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",13.071,-1.504,-1.386,3.74372,-2.595,0.06,89,91,-0.924,8,8,0,0,"helix",2,6.86,0.0002156101768003,9.70466975178797,9.70465898653047,9.70194990589383,2.29168245016684,18,0,0,0,0,0,0,0,0,2,2,-2,0,0,0,0,0,-3,2,-3,-2,8,0,0,8,-0.380952380952381,-0.358139534883721,0.136354431486243,-0.442455242966752,0.0337078651685393,0.936842105263158,-0.761120263591433,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-1.028,-0.872,"9:8","147/150","I:V:L:M:A:T:F",2.27260607808816,0.0634455902260904,1.22442760158496,1.8560559033024,0.929172866365899,208.881603004966,0.986980761010679,0.0776844925942494,1.10966566656461,0.504888890842109,570.372842410328,0.130068862702538,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR775350","ERR775350","lineage4.3.4.2","pe","","pnca_p.leu116pro","A","H","LEU","LA116","pnca_complex.pdb"
|
|
"L116P","L4","PZA","L","L116",116,"P",NA,"MDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",13.071,-1.504,-1.386,3.74372,-2.595,0.06,89,91,-0.924,8,8,0,0,"helix",2,6.86,0.0002156101768003,9.70466975178797,9.70465898653047,9.70194990589383,2.29168245016684,18,0,0,0,0,0,0,0,0,2,2,-2,0,0,0,0,0,-3,2,-3,-2,8,0,0,8,-0.380952380952381,-0.358139534883721,0.136354431486243,-0.442455242966752,0.0337078651685393,0.936842105263158,-0.761120263591433,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-1.028,-0.872,"9:8","147/150","I:V:L:M:A:T:F",2.27260607808816,0.0634455902260904,1.22442760158496,1.8560559033024,0.929172866365899,208.881603004966,0.986980761010679,0.0776844925942494,1.10966566656461,0.504888890842109,570.372842410328,0.130068862702538,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR775351","ERR775351","lineage4.3.4.2","pe","","pnca_p.leu116pro","A","H","LEU","LA116","pnca_complex.pdb"
|
|
"L116P","L4","PZA","L","L116",116,"P",NA,"MDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",13.071,-1.504,-1.386,3.74372,-2.595,0.06,89,91,-0.924,8,8,0,0,"helix",2,6.86,0.0002156101768003,9.70466975178797,9.70465898653047,9.70194990589383,2.29168245016684,18,0,0,0,0,0,0,0,0,2,2,-2,0,0,0,0,0,-3,2,-3,-2,8,0,0,8,-0.380952380952381,-0.358139534883721,0.136354431486243,-0.442455242966752,0.0337078651685393,0.936842105263158,-0.761120263591433,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-1.028,-0.872,"9:8","147/150","I:V:L:M:A:T:F",2.27260607808816,0.0634455902260904,1.22442760158496,1.8560559033024,0.929172866365899,208.881603004966,0.986980761010679,0.0776844925942494,1.10966566656461,0.504888890842109,570.372842410328,0.130068862702538,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR2510224","ERR2510224","lineage4.3.4.2","pe","Peru","pnca_p.leu116pro","A","H","LEU","LA116","pnca_complex.pdb"
|
|
"L116P","L4","PZA","L","L116",116,"P",NA,"MDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",13.071,-1.504,-1.386,3.74372,-2.595,0.06,89,91,-0.924,8,8,0,0,"helix",2,6.86,0.0002156101768003,9.70466975178797,9.70465898653047,9.70194990589383,2.29168245016684,18,0,0,0,0,0,0,0,0,2,2,-2,0,0,0,0,0,-3,2,-3,-2,8,0,0,8,-0.380952380952381,-0.358139534883721,0.136354431486243,-0.442455242966752,0.0337078651685393,0.936842105263158,-0.761120263591433,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-1.028,-0.872,"9:8","147/150","I:V:L:M:A:T:F",2.27260607808816,0.0634455902260904,1.22442760158496,1.8560559033024,0.929172866365899,208.881603004966,0.986980761010679,0.0776844925942494,1.10966566656461,0.504888890842109,570.372842410328,0.130068862702538,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR751582","ERR751582","lineage4.3.4.2","pe","","pnca_p.leu116pro","A","H","LEU","LA116","pnca_complex.pdb"
|
|
"L116P","L4","PZA","L","L116",116,"P",NA,"MDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",13.071,-1.504,-1.386,3.74372,-2.595,0.06,89,91,-0.924,8,8,0,0,"helix",2,6.86,0.0002156101768003,9.70466975178797,9.70465898653047,9.70194990589383,2.29168245016684,18,0,0,0,0,0,0,0,0,2,2,-2,0,0,0,0,0,-3,2,-3,-2,8,0,0,8,-0.380952380952381,-0.358139534883721,0.136354431486243,-0.442455242966752,0.0337078651685393,0.936842105263158,-0.761120263591433,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-1.028,-0.872,"9:8","147/150","I:V:L:M:A:T:F",2.27260607808816,0.0634455902260904,1.22442760158496,1.8560559033024,0.929172866365899,208.881603004966,0.986980761010679,0.0776844925942494,1.10966566656461,0.504888890842109,570.372842410328,0.130068862702538,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR775342","ERR775342","lineage4.3.4.2","pe","","pnca_p.leu116pro","A","H","LEU","LA116","pnca_complex.pdb"
|
|
"L116P","L4","PZA","L","L116",116,"P",NA,"MDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",13.071,-1.504,-1.386,3.74372,-2.595,0.06,89,91,-0.924,8,8,0,0,"helix",2,6.86,0.0002156101768003,9.70466975178797,9.70465898653047,9.70194990589383,2.29168245016684,18,0,0,0,0,0,0,0,0,2,2,-2,0,0,0,0,0,-3,2,-3,-2,8,0,0,8,-0.380952380952381,-0.358139534883721,0.136354431486243,-0.442455242966752,0.0337078651685393,0.936842105263158,-0.761120263591433,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-1.028,-0.872,"9:8","147/150","I:V:L:M:A:T:F",2.27260607808816,0.0634455902260904,1.22442760158496,1.8560559033024,0.929172866365899,208.881603004966,0.986980761010679,0.0776844925942494,1.10966566656461,0.504888890842109,570.372842410328,0.130068862702538,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR2510196","ERR2510196","lineage4.3.4.2","pe","Peru","pnca_p.leu116pro","A","H","LEU","LA116","pnca_complex.pdb"
|
|
"L116P","L2","PZA","L","L116",116,"P",1,"Pre-XDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",13.071,-1.504,-1.386,3.74372,-2.595,0.06,89,91,-0.924,8,8,0,0,"helix",2,6.86,0.0002156101768003,9.70466975178797,9.70465898653047,9.70194990589383,2.29168245016684,18,0,0,0,0,0,0,0,0,2,2,-2,0,0,0,0,0,-3,2,-3,-2,8,0,0,8,-0.380952380952381,-0.358139534883721,0.136354431486243,-0.442455242966752,0.0337078651685393,0.936842105263158,-0.761120263591433,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-1.028,-0.872,"9:8","147/150","I:V:L:M:A:T:F",2.27260607808816,0.0634455902260904,1.22442760158496,1.8560559033024,0.929172866365899,208.881603004966,0.986980761010679,0.0776844925942494,1.10966566656461,0.504888890842109,570.372842410328,0.130068862702538,"lineage2","dr_mutations_pyrazinamide","PRO",0,"ERR2510850","ERR2510850","lineage2.2.1","it","Italy","pnca_p.leu116pro","A","H","LEU","LA116","pnca_complex.pdb"
|
|
"L116R","L2","PZA","L","L116",116,"R",NA,"MDR","DM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",13.071,-0.78,-1.733,4.65552,-4.189,-1.89,85,91,-0.924,8,8,0,0,"helix",2,6.86,7.18700589334483e-05,9.70142977291842,188179.926264668,Inf,0.763784339928386,-54,-52,0,-2,-50,0,0,0,0,-2,0,-2,-2,0,0,0,0,-6,0,1,-7,-4,0,-12,0,-0.197568389057751,-0.447803617571059,0.169564172233189,-0.714236999147485,-0.494764397905759,0.894736842105263,-0.761120263591433,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.028,-0.872,"9:8","147/150","I:V:L:M:A:T:F",12.1451538387266,0.91902633742424,119.468044436243,0.101660271548248,5.01153666061721e-06,NA,0.986835744238421,0.170978870202674,0.767057556984365,0.124324963210678,Inf,0.382146811758261,"lineage2","dr_mutations_pyrazinamide","ARG",0,"SAMN02584643","SRR1166113_SRR1169084","lineage2.2.1","md","Moldova","pnca_p.leu116arg","A","H","LEU","LA116","pnca_complex.pdb"
|
|
"L116R","L2","PZA","L","L116",116,"R",1,"MDR","DM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",13.071,-0.78,-1.733,4.65552,-4.189,-1.89,85,91,-0.924,8,8,0,0,"helix",2,6.86,7.18700589334483e-05,9.70142977291842,188179.926264668,Inf,0.763784339928386,-54,-52,0,-2,-50,0,0,0,0,-2,0,-2,-2,0,0,0,0,-6,0,1,-7,-4,0,-12,0,-0.197568389057751,-0.447803617571059,0.169564172233189,-0.714236999147485,-0.494764397905759,0.894736842105263,-0.761120263591433,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.028,-0.872,"9:8","147/150","I:V:L:M:A:T:F",12.1451538387266,0.91902633742424,119.468044436243,0.101660271548248,5.01153666061721e-06,NA,0.986835744238421,0.170978870202674,0.767057556984365,0.124324963210678,Inf,0.382146811758261,"lineage2","dr_mutations_pyrazinamide","ARG",0,"MDR_6135","SRR6824355","lineage2.2.1","cn","China: Liaoyang City, Liaoning Province","pnca_p.leu116arg","A","H","LEU","LA116","pnca_complex.pdb"
|
|
"L116R","L2","PZA","L","L116",116,"R",NA,"MDR","DM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",13.071,-0.78,-1.733,4.65552,-4.189,-1.89,85,91,-0.924,8,8,0,0,"helix",2,6.86,7.18700589334483e-05,9.70142977291842,188179.926264668,Inf,0.763784339928386,-54,-52,0,-2,-50,0,0,0,0,-2,0,-2,-2,0,0,0,0,-6,0,1,-7,-4,0,-12,0,-0.197568389057751,-0.447803617571059,0.169564172233189,-0.714236999147485,-0.494764397905759,0.894736842105263,-0.761120263591433,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.028,-0.872,"9:8","147/150","I:V:L:M:A:T:F",12.1451538387266,0.91902633742424,119.468044436243,0.101660271548248,5.01153666061721e-06,NA,0.986835744238421,0.170978870202674,0.767057556984365,0.124324963210678,Inf,0.382146811758261,"lineage2","dr_mutations_pyrazinamide","ARG",0,"SRS797058","SRR1723561","lineage2.2.1","cn","China:Liaoning","pnca_p.leu116arg","A","H","LEU","LA116","pnca_complex.pdb"
|
|
"L116R","L4","PZA","L","L116",116,"R",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",13.071,-0.78,-1.733,4.65552,-4.189,-1.89,85,91,-0.924,8,8,0,0,"helix",2,6.86,7.18700589334483e-05,9.70142977291842,188179.926264668,Inf,0.763784339928386,-54,-52,0,-2,-50,0,0,0,0,-2,0,-2,-2,0,0,0,0,-6,0,1,-7,-4,0,-12,0,-0.197568389057751,-0.447803617571059,0.169564172233189,-0.714236999147485,-0.494764397905759,0.894736842105263,-0.761120263591433,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.028,-0.872,"9:8","147/150","I:V:L:M:A:T:F",12.1451538387266,0.91902633742424,119.468044436243,0.101660271548248,5.01153666061721e-06,NA,0.986835744238421,0.170978870202674,0.767057556984365,0.124324963210678,Inf,0.382146811758261,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERR1035309","ERR1035309","lineage4.3.4.1","br","Brazil","pnca_p.leu116arg","A","H","LEU","LA116","pnca_complex.pdb"
|
|
"L116R","L2","PZA","L","L116",116,"R",NA,"MDR","DM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",13.071,-0.78,-1.733,4.65552,-4.189,-1.89,85,91,-0.924,8,8,0,0,"helix",2,6.86,7.18700589334483e-05,9.70142977291842,188179.926264668,Inf,0.763784339928386,-54,-52,0,-2,-50,0,0,0,0,-2,0,-2,-2,0,0,0,0,-6,0,1,-7,-4,0,-12,0,-0.197568389057751,-0.447803617571059,0.169564172233189,-0.714236999147485,-0.494764397905759,0.894736842105263,-0.761120263591433,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.028,-0.872,"9:8","147/150","I:V:L:M:A:T:F",12.1451538387266,0.91902633742424,119.468044436243,0.101660271548248,5.01153666061721e-06,NA,0.986835744238421,0.170978870202674,0.767057556984365,0.124324963210678,Inf,0.382146811758261,"lineage2","dr_mutations_pyrazinamide","ARG",0,"SRR8237325","SRR8237325","lineage2.2.1","np","","pnca_p.leu116arg","A","H","LEU","LA116","pnca_complex.pdb"
|
|
"L116R","L4","PZA","L","L116",116,"R",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",13.071,-0.78,-1.733,4.65552,-4.189,-1.89,85,91,-0.924,8,8,0,0,"helix",2,6.86,7.18700589334483e-05,9.70142977291842,188179.926264668,Inf,0.763784339928386,-54,-52,0,-2,-50,0,0,0,0,-2,0,-2,-2,0,0,0,0,-6,0,1,-7,-4,0,-12,0,-0.197568389057751,-0.447803617571059,0.169564172233189,-0.714236999147485,-0.494764397905759,0.894736842105263,-0.761120263591433,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.028,-0.872,"9:8","147/150","I:V:L:M:A:T:F",12.1451538387266,0.91902633742424,119.468044436243,0.101660271548248,5.01153666061721e-06,NA,0.986835744238421,0.170978870202674,0.767057556984365,0.124324963210678,Inf,0.382146811758261,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERR1035328","ERR1035328","lineage4.3.4.1","br","Brazil","pnca_p.leu116arg","A","H","LEU","LA116","pnca_complex.pdb"
|
|
"L116R","L2","PZA","L","L116",116,"R",NA,"MDR","DM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",13.071,-0.78,-1.733,4.65552,-4.189,-1.89,85,91,-0.924,8,8,0,0,"helix",2,6.86,7.18700589334483e-05,9.70142977291842,188179.926264668,Inf,0.763784339928386,-54,-52,0,-2,-50,0,0,0,0,-2,0,-2,-2,0,0,0,0,-6,0,1,-7,-4,0,-12,0,-0.197568389057751,-0.447803617571059,0.169564172233189,-0.714236999147485,-0.494764397905759,0.894736842105263,-0.761120263591433,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.028,-0.872,"9:8","147/150","I:V:L:M:A:T:F",12.1451538387266,0.91902633742424,119.468044436243,0.101660271548248,5.01153666061721e-06,NA,0.986835744238421,0.170978870202674,0.767057556984365,0.124324963210678,Inf,0.382146811758261,"lineage2","dr_mutations_pyrazinamide","ARG",0,"SAMN02584605","SRR1166088_SRR1168990","lineage2.2.1","md","Moldova","pnca_p.leu116arg","A","H","LEU","LA116","pnca_complex.pdb"
|
|
"L116V","L2","PZA","L","L116",116,"V",0,"XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",13.071,-1.648,-1.084,1.87491,-1.706,0.62,48,71,-0.924,8,8,0,0,"helix",2,6.86,7.18700589334483e-05,2.42412778478352,0.0001249735077034,0,1.03410070803344e-29,20,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,2,0,2,0,2,0,0,2,-0.41742654508612,-0.280103359173127,0.0682883033821633,-0.290878090366581,0.348314606741573,0.505263157894737,-0.761120263591433,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-1.028,-0.872,"9:8","147/150","I:V:L:M:A:T:F",-8.98740878149641,0.940032862253634,119.468044435492,-0.0752285585987746,NA,4692673.510814,0.384555509373631,1,0,0,188.544222231268,0.999999999999997,"lineage2","dr_mutations_pyrazinamide","VAL",0,"ERS1831679","ERR2041934","lineage2.2.1","","Germany_extendedCAO","pnca_p.leu116val","A","H","LEU","LA116","pnca_complex.pdb"
|
|
"L117R","L2","PZA","L","L117",117,"R",0,"MDR","OM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",17.11,-0.585,-0.678,0.0947913,-1.884,-0.23,9,53,0.447,3,3,50,0.248756218905473,"helix",1.36666666666667,4.46,7.18700589334483e-05,2.42412778478352,0.0001249735077034,0,1.03410070803344e-29,-28,-26,0,-2,-24,0,0,0,0,-2,0,-2,-2,0,0,0,0,4,0,1,4,2,0,2,0,-0.148176291793313,-0.175193798449612,0.0034525054815376,-0.321227621483376,-0.0602094240837696,0.0947368421052632,0.143269230769231,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.083,0.59,"5:3","147/150","D:P:G:S:A:T:K:V:L:E:H",-8.98740878149642,0.940032862253633,119.468044435491,-0.0752285585987753,NA,4692673.51081308,0.384555509373631,1,0,0,188.544222231268,0.999999999999997,"lineage2","other_mutations_pyrazinamide","ARG",0,"MDR_25142","SRR6824543","lineage2.2.1","cn","China: Tonghai County, Yuxi City, Yunnan Province","pnca_p.leu117arg","A","H","LEU","LA117","pnca_complex.pdb"
|
|
"L117R","L2","PZA","L","L117",117,"R",NA,"MDR","OM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",17.11,-0.585,-0.678,0.0947913,-1.884,-0.23,9,53,0.447,3,3,50,0.248756218905473,"helix",1.36666666666667,4.46,7.18700589334483e-05,2.42412778478352,0.0001249735077034,0,1.03410070803344e-29,-28,-26,0,-2,-24,0,0,0,0,-2,0,-2,-2,0,0,0,0,4,0,1,4,2,0,2,0,-0.148176291793313,-0.175193798449612,0.0034525054815376,-0.321227621483376,-0.0602094240837696,0.0947368421052632,0.143269230769231,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.083,0.59,"5:3","147/150","D:P:G:S:A:T:K:V:L:E:H",-8.98740878149642,0.940032862253633,119.468044435491,-0.0752285585987753,NA,4692673.51081308,0.384555509373631,1,0,0,188.544222231268,0.999999999999997,"lineage2","other_mutations_pyrazinamide","ARG",0,"SRS797095","SRR1723601","lineage2.2.1","cn","China:Yunnan","pnca_p.leu117arg","A","H","LEU","LA117","pnca_complex.pdb"
|
|
"N118E","L4","PZA","N","N118",118,"E",NA,"Pre-MDR","OM","hydrophilic","hydrophilic","neutral","acidic","polar","neg",19.738,-0.713,0.78,-2.32726,0.371,-0.19,-29,61,0.692,2,2,80,0.41025641025641,"helix",-0.2,4.06,NA,NA,NA,NA,NA,-6,-14,0,0,-14,0,0,0,0,-2,0,0,-4,0,0,0,0,0,0,0,-2,-2,0,0,0,-0.180597771023303,0.663265306122449,-0.447446743059294,0.313344594594595,-0.0497382198952879,-0.311827956989247,0.221794871794872,"Destabilising","Stabilising","Stabilising","Stabilising","Destabilising","neutral",0.389,0.842,"4:2","146/150","N:R:K:E:Y:Q:D:A:M:S:G:T",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage4","other_mutations_pyrazinamide","GLU",0,"SRR6325445","SRR6325445","lineage4.3","us","","pnca_p.asn118glu","A","H","ASN","NA118","pnca_complex.pdb"
|
|
"N118E","L3;L4","PZA","N","N118",118,"E",NA,"Pre-MDR","OM","hydrophilic","hydrophilic","neutral","acidic","polar","neg",19.738,-0.713,0.78,-2.32726,0.371,-0.19,-29,61,0.692,2,2,80,0.41025641025641,"helix",-0.2,4.06,NA,NA,NA,NA,NA,-6,-14,0,0,-14,0,0,0,0,-2,0,0,-4,0,0,0,0,0,0,0,-2,-2,0,0,0,-0.180597771023303,0.663265306122449,-0.447446743059294,0.313344594594595,-0.0497382198952879,-0.311827956989247,0.221794871794872,"Destabilising","Stabilising","Stabilising","Stabilising","Destabilising","neutral",0.389,0.842,"4:2","146/150","N:R:K:E:Y:Q:D:A:M:S:G:T",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage3;lineage4","other_mutations_pyrazinamide","GLU",0,"SRR6325444","SRR6325444","lineage4.3;lineage3","us","","pnca_p.asn118glu","A","H","ASN","NA118","pnca_complex.pdb"
|
|
"N118E","L4","PZA","N","N118",118,"E",NA,"Pre-MDR","OM","hydrophilic","hydrophilic","neutral","acidic","polar","neg",19.738,-0.713,0.78,-2.32726,0.371,-0.19,-29,61,0.692,2,2,80,0.41025641025641,"helix",-0.2,4.06,NA,NA,NA,NA,NA,-6,-14,0,0,-14,0,0,0,0,-2,0,0,-4,0,0,0,0,0,0,0,-2,-2,0,0,0,-0.180597771023303,0.663265306122449,-0.447446743059294,0.313344594594595,-0.0497382198952879,-0.311827956989247,0.221794871794872,"Destabilising","Stabilising","Stabilising","Stabilising","Destabilising","neutral",0.389,0.842,"4:2","146/150","N:R:K:E:Y:Q:D:A:M:S:G:T",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage4","other_mutations_pyrazinamide","GLU",0,"SRR6325448","SRR6325448","lineage4.3","us","","pnca_p.asn118glu","A","H","ASN","NA118","pnca_complex.pdb"
|
|
"W119C","L2","PZA","W","W119",119,"C",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",19.722,-1.498,-1.743,4.0665,-2.343,-1.91,48,71,0.224,4,4,14,0.0491228070175438,"helix",-0.2,5.7,7.18700589334483e-05,9.70142977291842,188179.926264578,Inf,0.763784339928386,42,0,0,0,0,0,0,0,0,-2,0,-2,0,0,0,0,0,3,0,-1,4,12,0,10,10,-0.379432624113475,-0.450387596899225,0.148110781692757,-0.399488491048593,-0.5,0.505263157894737,0.0717948717948718,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","146/150","T:G:S:M:A:W:Q:F:E:Y:I:R:L:V",12.1451538387261,0.919026337424224,119.468044436214,0.101660271548269,5.01153666064432e-06,NA,0.986835744238421,0.170978870202674,0.767057556984365,0.124324963210678,Inf,0.382146811758261,"lineage2","dr_mutations_pyrazinamide","CYS",0,"SRR5266547","SRR5266547","lineage2.2.1","ru","Russia","pnca_p.trp119cys","A","H","TRP","WA119","pnca_complex.pdb"
|
|
"W119C","L5","PZA","W","W119",119,"C",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",19.722,-1.498,-1.743,4.0665,-2.343,-1.91,48,71,0.224,4,4,14,0.0491228070175438,"helix",-0.2,5.7,7.18700589334483e-05,9.70142977291842,188179.926264578,Inf,0.763784339928386,42,0,0,0,0,0,0,0,0,-2,0,-2,0,0,0,0,0,3,0,-1,4,12,0,10,10,-0.379432624113475,-0.450387596899225,0.148110781692757,-0.399488491048593,-0.5,0.505263157894737,0.0717948717948718,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","146/150","T:G:S:M:A:W:Q:F:E:Y:I:R:L:V",12.1451538387261,0.919026337424224,119.468044436214,0.101660271548269,5.01153666064432e-06,NA,0.986835744238421,0.170978870202674,0.767057556984365,0.124324963210678,Inf,0.382146811758261,"lineage5","dr_mutations_pyrazinamide","CYS",0,"ERR751330","ERR751330","lineage5","gh","Ghana","pnca_p.trp119cys","A","H","TRP","WA119","pnca_complex.pdb"
|
|
"W119C","L5","PZA","W","W119",119,"C",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",19.722,-1.498,-1.743,4.0665,-2.343,-1.91,48,71,0.224,4,4,14,0.0491228070175438,"helix",-0.2,5.7,7.18700589334483e-05,9.70142977291842,188179.926264578,Inf,0.763784339928386,42,0,0,0,0,0,0,0,0,-2,0,-2,0,0,0,0,0,3,0,-1,4,12,0,10,10,-0.379432624113475,-0.450387596899225,0.148110781692757,-0.399488491048593,-0.5,0.505263157894737,0.0717948717948718,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","146/150","T:G:S:M:A:W:Q:F:E:Y:I:R:L:V",12.1451538387261,0.919026337424224,119.468044436214,0.101660271548269,5.01153666064432e-06,NA,0.986835744238421,0.170978870202674,0.767057556984365,0.124324963210678,Inf,0.382146811758261,"lineage5","dr_mutations_pyrazinamide","CYS",0,"ERR702432","ERR702432","lineage5","gh","Ghana","pnca_p.trp119cys","A","H","TRP","WA119","pnca_complex.pdb"
|
|
"W119C","L5","PZA","W","W119",119,"C",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",19.722,-1.498,-1.743,4.0665,-2.343,-1.91,48,71,0.224,4,4,14,0.0491228070175438,"helix",-0.2,5.7,7.18700589334483e-05,9.70142977291842,188179.926264578,Inf,0.763784339928386,42,0,0,0,0,0,0,0,0,-2,0,-2,0,0,0,0,0,3,0,-1,4,12,0,10,10,-0.379432624113475,-0.450387596899225,0.148110781692757,-0.399488491048593,-0.5,0.505263157894737,0.0717948717948718,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","146/150","T:G:S:M:A:W:Q:F:E:Y:I:R:L:V",12.1451538387261,0.919026337424224,119.468044436214,0.101660271548269,5.01153666064432e-06,NA,0.986835744238421,0.170978870202674,0.767057556984365,0.124324963210678,Inf,0.382146811758261,"lineage5","dr_mutations_pyrazinamide","CYS",0,"ERR2181457","ERR2181457","lineage5","gh","Ghana","pnca_p.trp119cys","A","H","TRP","WA119","pnca_complex.pdb"
|
|
"W119C","L3","PZA","W","W119",119,"C",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",19.722,-1.498,-1.743,4.0665,-2.343,-1.91,48,71,0.224,4,4,14,0.0491228070175438,"helix",-0.2,5.7,7.18700589334483e-05,9.70142977291842,188179.926264578,Inf,0.763784339928386,42,0,0,0,0,0,0,0,0,-2,0,-2,0,0,0,0,0,3,0,-1,4,12,0,10,10,-0.379432624113475,-0.450387596899225,0.148110781692757,-0.399488491048593,-0.5,0.505263157894737,0.0717948717948718,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","146/150","T:G:S:M:A:W:Q:F:E:Y:I:R:L:V",12.1451538387261,0.919026337424224,119.468044436214,0.101660271548269,5.01153666064432e-06,NA,0.986835744238421,0.170978870202674,0.767057556984365,0.124324963210678,Inf,0.382146811758261,"lineage3","dr_mutations_pyrazinamide","CYS",0,"SAMN02414870","SRR1163051_SRR1144789_SRR1163146_SRR1146416","lineage3","se","Sweden","pnca_p.trp119cys","A","H","TRP","WA119","pnca_complex.pdb"
|
|
"W119C","L4","PZA","W","W119",119,"C",1,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",19.722,-1.498,-1.743,4.0665,-2.343,-1.91,48,71,0.224,4,4,14,0.0491228070175438,"helix",-0.2,5.7,7.18700589334483e-05,9.70142977291842,188179.926264578,Inf,0.763784339928386,42,0,0,0,0,0,0,0,0,-2,0,-2,0,0,0,0,0,3,0,-1,4,12,0,10,10,-0.379432624113475,-0.450387596899225,0.148110781692757,-0.399488491048593,-0.5,0.505263157894737,0.0717948717948718,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","146/150","T:G:S:M:A:W:Q:F:E:Y:I:R:L:V",12.1451538387261,0.919026337424224,119.468044436214,0.101660271548269,5.01153666064432e-06,NA,0.986835744238421,0.170978870202674,0.767057556984365,0.124324963210678,Inf,0.382146811758261,"lineage4","dr_mutations_pyrazinamide","CYS",0,"SAMN10961360","SRR8651601","lineage4.4.2","cn","China:Wenzhou","pnca_p.trp119cys","A","H","TRP","WA119","pnca_complex.pdb"
|
|
"W119G","L4","PZA","W","W119",119,"G",1,"MDR","OM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",19.722,-1.84,-2.983,5.88168,-3.318,-3.39,70,85,0.224,4,4,14,0.0491228070175438,"helix",-0.2,5.7,0.0001437401178668,19.411022297013,511754.463552391,Inf,4.73122070382274,52,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,0,-3,6,18,0,15,31,-0.466058763931104,-0.770801033591731,0.214223588458541,-0.565728900255755,-0.887434554973822,0.736842105263158,0.0717948717948718,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","146/150","T:G:S:M:A:W:Q:F:E:Y:I:R:L:V",13.1456002256201,0.924803768446985,139.277183326538,0.0943844491369419,0.0001628371344459,NA,1.28804840845689,0.0292235860951597,1.53426649183163,0.91081598550184,Inf,0.0296198560706035,"lineage4","other_mutations_pyrazinamide","GLY",0,"ERR2516678","ERR2516678","lineage4","pe","Peru","pnca_p.trp119gly","A","H","TRP","WA119","pnca_complex.pdb"
|
|
"W119G","L2;L4","PZA","W","W119",119,"G",1,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",19.722,-1.84,-2.983,5.88168,-3.318,-3.39,70,85,0.224,4,4,14,0.0491228070175438,"helix",-0.2,5.7,0.0001437401178668,19.411022297013,511754.463552391,Inf,4.73122070382274,52,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,0,-3,6,18,0,15,31,-0.466058763931104,-0.770801033591731,0.214223588458541,-0.565728900255755,-0.887434554973822,0.736842105263158,0.0717948717948718,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","146/150","T:G:S:M:A:W:Q:F:E:Y:I:R:L:V",13.1456002256201,0.924803768446985,139.277183326538,0.0943844491369419,0.0001628371344459,NA,1.28804840845689,0.0292235860951597,1.53426649183163,0.91081598550184,Inf,0.0296198560706035,"lineage2;lineage4","other_mutations_pyrazinamide","GLY",0,"ERR2516648","ERR2516648","lineage4;lineage2.2.1","pe","Peru","pnca_p.trp119gly","A","H","TRP","WA119","pnca_complex.pdb"
|
|
"W119L","L2","PZA","W","W119",119,"L",NA,"MDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",19.722,-2.11,-1.981,2.39227,-1.186,-1.92,32,66,0.224,4,4,14,0.0491228070175438,"helix",-0.2,5.7,NA,NA,NA,NA,NA,22,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,1,12,0,6,8,-0.534447821681864,-0.511886304909561,0.0871316807377676,-0.202216538789429,-0.50261780104712,0.336842105263158,0.0717948717948718,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","146/150","T:G:S:M:A:W:Q:F:E:Y:I:R:L:V",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage2","other_mutations_pyrazinamide","LEU",0,"ERR775375","ERR775375","lineage2.2.1","pe","","pnca_p.trp119leu","A","H","TRP","WA119","pnca_complex.pdb"
|
|
"W119L","L2","PZA","W","W119",119,"L",NA,"MDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",19.722,-2.11,-1.981,2.39227,-1.186,-1.92,32,66,0.224,4,4,14,0.0491228070175438,"helix",-0.2,5.7,NA,NA,NA,NA,NA,22,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,1,12,0,6,8,-0.534447821681864,-0.511886304909561,0.0871316807377676,-0.202216538789429,-0.50261780104712,0.336842105263158,0.0717948717948718,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","146/150","T:G:S:M:A:W:Q:F:E:Y:I:R:L:V",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage2","other_mutations_pyrazinamide","LEU",0,"SRR671806,BGI_SH166","SRR671806","lineage2.2.1","cn","China","pnca_p.trp119leu","A","H","TRP","WA119","pnca_complex.pdb"
|
|
"W119R","L2","PZA","W","W119",119,"R",0,"MDR","DM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",19.722,-0.807,-1.874,3.61213,-2.916,-1.89,70,85,0.224,4,4,14,0.0491228070175438,"helix",-0.2,5.7,0.0005030904125341,6.47410526315789,6.47410517670654,6.47281975099898,5.34879705543722,-4,-30,0,-2,-28,0,0,0,0,-2,0,0,-2,0,0,0,0,-2,0,-5,-1,0,0,2,0,-0.204407294832827,-0.484237726098191,0.131561637249689,-0.497186700767263,-0.494764397905759,0.736842105263158,0.0717948717948718,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","146/150","T:G:S:M:A:W:Q:F:E:Y:I:R:L:V",1.86781040138793,0.0145043045254536,0.764079088633846,2.44452495713176,1.4262375473788,32.8877353882417,0.811179756363585,0.0192724555107824,1.71506294819644,1.09429403734416,44.2397805449942,0.0207365726835135,"lineage2","dr_mutations_pyrazinamide","ARG",0,"ERR2516865","ERR2516865","lineage2.2.1","gb","UK","pnca_p.trp119arg","A","H","TRP","WA119","pnca_complex.pdb"
|
|
"W119R","L2","PZA","W","W119",119,"R",1,"MDR","DM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",19.722,-0.807,-1.874,3.61213,-2.916,-1.89,70,85,0.224,4,4,14,0.0491228070175438,"helix",-0.2,5.7,0.0005030904125341,6.47410526315789,6.47410517670654,6.47281975099898,5.34879705543722,-4,-30,0,-2,-28,0,0,0,0,-2,0,0,-2,0,0,0,0,-2,0,-5,-1,0,0,2,0,-0.204407294832827,-0.484237726098191,0.131561637249689,-0.497186700767263,-0.494764397905759,0.736842105263158,0.0717948717948718,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","146/150","T:G:S:M:A:W:Q:F:E:Y:I:R:L:V",1.86781040138793,0.0145043045254536,0.764079088633846,2.44452495713176,1.4262375473788,32.8877353882417,0.811179756363585,0.0192724555107824,1.71506294819644,1.09429403734416,44.2397805449942,0.0207365726835135,"lineage2","dr_mutations_pyrazinamide","ARG",0,"MDR_10448","SRR6824681","lineage2.2.1","cn","China: Pei County, Xuzhou City, Jiangsu Province","pnca_p.trp119arg","A","H","TRP","WA119","pnca_complex.pdb"
|
|
"W119R","L1","PZA","W","W119",119,"R",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",19.722,-0.807,-1.874,3.61213,-2.916,-1.89,70,85,0.224,4,4,14,0.0491228070175438,"helix",-0.2,5.7,0.0005030904125341,6.47410526315789,6.47410517670654,6.47281975099898,5.34879705543722,-4,-30,0,-2,-28,0,0,0,0,-2,0,0,-2,0,0,0,0,-2,0,-5,-1,0,0,2,0,-0.204407294832827,-0.484237726098191,0.131561637249689,-0.497186700767263,-0.494764397905759,0.736842105263158,0.0717948717948718,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","146/150","T:G:S:M:A:W:Q:F:E:Y:I:R:L:V",1.86781040138793,0.0145043045254536,0.764079088633846,2.44452495713176,1.4262375473788,32.8877353882417,0.811179756363585,0.0192724555107824,1.71506294819644,1.09429403734416,44.2397805449942,0.0207365726835135,"lineage1","dr_mutations_pyrazinamide","ARG",0,"SAMN09708347","SRR7585423","lineage1.2.2","in","India","pnca_p.trp119arg","A","H","TRP","WA119","pnca_complex.pdb"
|
|
"W119R","L3","PZA","W","W119",119,"R",1,"MDR","DM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",19.722,-0.807,-1.874,3.61213,-2.916,-1.89,70,85,0.224,4,4,14,0.0491228070175438,"helix",-0.2,5.7,0.0005030904125341,6.47410526315789,6.47410517670654,6.47281975099898,5.34879705543722,-4,-30,0,-2,-28,0,0,0,0,-2,0,0,-2,0,0,0,0,-2,0,-5,-1,0,0,2,0,-0.204407294832827,-0.484237726098191,0.131561637249689,-0.497186700767263,-0.494764397905759,0.736842105263158,0.0717948717948718,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","146/150","T:G:S:M:A:W:Q:F:E:Y:I:R:L:V",1.86781040138793,0.0145043045254536,0.764079088633846,2.44452495713176,1.4262375473788,32.8877353882417,0.811179756363585,0.0192724555107824,1.71506294819644,1.09429403734416,44.2397805449942,0.0207365726835135,"lineage3","dr_mutations_pyrazinamide","ARG",0,"ERR2517371","ERR2517371","lineage3.1.1","nl","Netherlands","pnca_p.trp119arg","A","H","TRP","WA119","pnca_complex.pdb"
|
|
"W119R","L2","PZA","W","W119",119,"R",NA,"MDR","DM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",19.722,-0.807,-1.874,3.61213,-2.916,-1.89,70,85,0.224,4,4,14,0.0491228070175438,"helix",-0.2,5.7,0.0005030904125341,6.47410526315789,6.47410517670654,6.47281975099898,5.34879705543722,-4,-30,0,-2,-28,0,0,0,0,-2,0,0,-2,0,0,0,0,-2,0,-5,-1,0,0,2,0,-0.204407294832827,-0.484237726098191,0.131561637249689,-0.497186700767263,-0.494764397905759,0.736842105263158,0.0717948717948718,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","146/150","T:G:S:M:A:W:Q:F:E:Y:I:R:L:V",1.86781040138793,0.0145043045254536,0.764079088633846,2.44452495713176,1.4262375473788,32.8877353882417,0.811179756363585,0.0192724555107824,1.71506294819644,1.09429403734416,44.2397805449942,0.0207365726835135,"lineage2","dr_mutations_pyrazinamide","ARG",0,"SRS797352","SRR1723886","lineage2.2.1","cn","China:Jiangsu","pnca_p.trp119arg","A","H","TRP","WA119","pnca_complex.pdb"
|
|
"W119R","L2","PZA","W","W119",119,"R",0,"Pre-XDR","DM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",19.722,-0.807,-1.874,3.61213,-2.916,-1.89,70,85,0.224,4,4,14,0.0491228070175438,"helix",-0.2,5.7,0.0005030904125341,6.47410526315789,6.47410517670654,6.47281975099898,5.34879705543722,-4,-30,0,-2,-28,0,0,0,0,-2,0,0,-2,0,0,0,0,-2,0,-5,-1,0,0,2,0,-0.204407294832827,-0.484237726098191,0.131561637249689,-0.497186700767263,-0.494764397905759,0.736842105263158,0.0717948717948718,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","146/150","T:G:S:M:A:W:Q:F:E:Y:I:R:L:V",1.86781040138793,0.0145043045254536,0.764079088633846,2.44452495713176,1.4262375473788,32.8877353882417,0.811179756363585,0.0192724555107824,1.71506294819644,1.09429403734416,44.2397805449942,0.0207365726835135,"lineage2","dr_mutations_pyrazinamide","ARG",0,"ERR2510534","ERR2510534","lineage2.2.1.2","pk","Pakistan","pnca_p.trp119arg","A","H","TRP","WA119","pnca_complex.pdb"
|
|
"W119R","L2","PZA","W","W119",119,"R",1,"Pre-XDR","DM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",19.722,-0.807,-1.874,3.61213,-2.916,-1.89,70,85,0.224,4,4,14,0.0491228070175438,"helix",-0.2,5.7,0.0005030904125341,6.47410526315789,6.47410517670654,6.47281975099898,5.34879705543722,-4,-30,0,-2,-28,0,0,0,0,-2,0,0,-2,0,0,0,0,-2,0,-5,-1,0,0,2,0,-0.204407294832827,-0.484237726098191,0.131561637249689,-0.497186700767263,-0.494764397905759,0.736842105263158,0.0717948717948718,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","146/150","T:G:S:M:A:W:Q:F:E:Y:I:R:L:V",1.86781040138793,0.0145043045254536,0.764079088633846,2.44452495713176,1.4262375473788,32.8877353882417,0.811179756363585,0.0192724555107824,1.71506294819644,1.09429403734416,44.2397805449942,0.0207365726835135,"lineage2","dr_mutations_pyrazinamide","ARG",0,"ERR2510293","ERR2510293","lineage2.2.1.2","pk","Pakistan","pnca_p.trp119arg","A","H","TRP","WA119","pnca_complex.pdb"
|
|
"W119R","L2","PZA","W","W119",119,"R",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",19.722,-0.807,-1.874,3.61213,-2.916,-1.89,70,85,0.224,4,4,14,0.0491228070175438,"helix",-0.2,5.7,0.0005030904125341,6.47410526315789,6.47410517670654,6.47281975099898,5.34879705543722,-4,-30,0,-2,-28,0,0,0,0,-2,0,0,-2,0,0,0,0,-2,0,-5,-1,0,0,2,0,-0.204407294832827,-0.484237726098191,0.131561637249689,-0.497186700767263,-0.494764397905759,0.736842105263158,0.0717948717948718,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","146/150","T:G:S:M:A:W:Q:F:E:Y:I:R:L:V",1.86781040138793,0.0145043045254536,0.764079088633846,2.44452495713176,1.4262375473788,32.8877353882417,0.811179756363585,0.0192724555107824,1.71506294819644,1.09429403734416,44.2397805449942,0.0207365726835135,"lineage2","dr_mutations_pyrazinamide","ARG",0,"SAMN07236299,SRR5709748","SRR5709748","lineage2.1","th","Thailand","pnca_p.trp119arg","A","H","TRP","WA119","pnca_complex.pdb"
|
|
"W119R","L2","PZA","W","W119",119,"R",1,"Pre-XDR","DM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",19.722,-0.807,-1.874,3.61213,-2.916,-1.89,70,85,0.224,4,4,14,0.0491228070175438,"helix",-0.2,5.7,0.0005030904125341,6.47410526315789,6.47410517670654,6.47281975099898,5.34879705543722,-4,-30,0,-2,-28,0,0,0,0,-2,0,0,-2,0,0,0,0,-2,0,-5,-1,0,0,2,0,-0.204407294832827,-0.484237726098191,0.131561637249689,-0.497186700767263,-0.494764397905759,0.736842105263158,0.0717948717948718,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","146/150","T:G:S:M:A:W:Q:F:E:Y:I:R:L:V",1.86781040138793,0.0145043045254536,0.764079088633846,2.44452495713176,1.4262375473788,32.8877353882417,0.811179756363585,0.0192724555107824,1.71506294819644,1.09429403734416,44.2397805449942,0.0207365726835135,"lineage2","dr_mutations_pyrazinamide","ARG",0,"ERR027450","ERR027450","lineage2.2.1","ru","Russia","pnca_p.trp119arg","A","H","TRP","WA119","pnca_complex.pdb"
|
|
"W119R","L3","PZA","W","W119",119,"R",0,"Pre-XDR","DM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",19.722,-0.807,-1.874,3.61213,-2.916,-1.89,70,85,0.224,4,4,14,0.0491228070175438,"helix",-0.2,5.7,0.0005030904125341,6.47410526315789,6.47410517670654,6.47281975099898,5.34879705543722,-4,-30,0,-2,-28,0,0,0,0,-2,0,0,-2,0,0,0,0,-2,0,-5,-1,0,0,2,0,-0.204407294832827,-0.484237726098191,0.131561637249689,-0.497186700767263,-0.494764397905759,0.736842105263158,0.0717948717948718,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","146/150","T:G:S:M:A:W:Q:F:E:Y:I:R:L:V",1.86781040138793,0.0145043045254536,0.764079088633846,2.44452495713176,1.4262375473788,32.8877353882417,0.811179756363585,0.0192724555107824,1.71506294819644,1.09429403734416,44.2397805449942,0.0207365726835135,"lineage3","dr_mutations_pyrazinamide","ARG",0,"ERR2510260","ERR2510260","lineage3","pk","Pakistan","pnca_p.trp119arg","A","H","TRP","WA119","pnca_complex.pdb"
|
|
"W119S","L4","PZA","W","W119",119,"S",1,"MDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",19.722,-0.995,-3.136,4.6385,-2.258,-3.44,66,80,0.224,4,4,14,0.0491228070175438,"helix",-0.2,5.7,0.0001437401178668,19.411022297013,511754.463554449,Inf,4.73122070382274,44,0,0,0,0,0,0,0,0,-2,0,-2,0,0,0,0,0,6,0,0,6,14,0,10,12,-0.252026342451874,-0.810335917312662,0.16894426678516,-0.384995737425405,-0.900523560209424,0.694736842105263,0.0717948717948718,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","146/150","T:G:S:M:A:W:Q:F:E:Y:I:R:L:V",13.1456002256241,0.924803768447112,139.277183326815,0.0943844491367826,0.0001628371344395,NA,1.28804840845689,0.0292235860951597,1.53426649183163,0.91081598550184,Inf,0.0296198560706035,"lineage4","dr_mutations_pyrazinamide","SER",0,"ERR2516993","ERR2516993","lineage4.1.2.1","gb","UK","pnca_p.trp119ser","A","H","TRP","WA119","pnca_complex.pdb"
|
|
"W119S","L4","PZA","W","W119",119,"S",1,"MDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",19.722,-0.995,-3.136,4.6385,-2.258,-3.44,66,80,0.224,4,4,14,0.0491228070175438,"helix",-0.2,5.7,0.0001437401178668,19.411022297013,511754.463554449,Inf,4.73122070382274,44,0,0,0,0,0,0,0,0,-2,0,-2,0,0,0,0,0,6,0,0,6,14,0,10,12,-0.252026342451874,-0.810335917312662,0.16894426678516,-0.384995737425405,-0.900523560209424,0.694736842105263,0.0717948717948718,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","146/150","T:G:S:M:A:W:Q:F:E:Y:I:R:L:V",13.1456002256241,0.924803768447112,139.277183326815,0.0943844491367826,0.0001628371344395,NA,1.28804840845689,0.0292235860951597,1.53426649183163,0.91081598550184,Inf,0.0296198560706035,"lineage4","dr_mutations_pyrazinamide","SER",0,"ERR2516774","ERR2516774","lineage4.1.2.1","gb","UK","pnca_p.trp119ser","A","H","TRP","WA119","pnca_complex.pdb"
|
|
"L120P","L4","PZA","L","L120",120,"P",NA,"MDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",17.55,-1.644,-2.181,7.59698,-4.748,-1.51,79,85,-1.142,9,9,0,0,"helix",-0.533333333333334,8.07,0.0018686215322696,254.917127071823,3820001.12561286,Inf,120.509921037495,16,16,0,0,16,0,0,0,0,2,2,2,-2,0,0,0,0,0,4,-4,-2,8,0,2,4,-0.416413373860182,-0.563565891472868,0.276698548212035,-0.809548167092924,-0.395287958115183,0.831578947368421,-0.940691927512356,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.201,-1.124,"9:9","147/150","F:V:L",15.1557612752458,0.885234541058746,105.002771503186,0.14433677376588,15316.7789340045,20462689242793896,2.40639901531589,1.01650823124183e-20,19.9928891002838,32.1173872780919,Inf,4.89215110948636e-28,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR3148160","ERR3148160","lineage4.1.1.3","mx","Mexico","pnca_p.leu120pro","A","H","LEU","LA120","pnca_complex.pdb"
|
|
"L120P","L4","PZA","L","L120",120,"P",1,"XDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",17.55,-1.644,-2.181,7.59698,-4.748,-1.51,79,85,-1.142,9,9,0,0,"helix",-0.533333333333334,8.07,0.0018686215322696,254.917127071823,3820001.12561286,Inf,120.509921037495,16,16,0,0,16,0,0,0,0,2,2,2,-2,0,0,0,0,0,4,-4,-2,8,0,2,4,-0.416413373860182,-0.563565891472868,0.276698548212035,-0.809548167092924,-0.395287958115183,0.831578947368421,-0.940691927512356,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.201,-1.124,"9:9","147/150","F:V:L",15.1557612752458,0.885234541058746,105.002771503186,0.14433677376588,15316.7789340045,20462689242793896,2.40639901531589,1.01650823124183e-20,19.9928891002838,32.1173872780919,Inf,4.89215110948636e-28,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR1036276","ERR1036276","lineage4.3.4.2","pt","Portugal","pnca_p.leu120pro","A","H","LEU","LA120","pnca_complex.pdb"
|
|
"L120P","L4","PZA","L","L120",120,"P",1,"XDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",17.55,-1.644,-2.181,7.59698,-4.748,-1.51,79,85,-1.142,9,9,0,0,"helix",-0.533333333333334,8.07,0.0018686215322696,254.917127071823,3820001.12561286,Inf,120.509921037495,16,16,0,0,16,0,0,0,0,2,2,2,-2,0,0,0,0,0,4,-4,-2,8,0,2,4,-0.416413373860182,-0.563565891472868,0.276698548212035,-0.809548167092924,-0.395287958115183,0.831578947368421,-0.940691927512356,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.201,-1.124,"9:9","147/150","F:V:L",15.1557612752458,0.885234541058746,105.002771503186,0.14433677376588,15316.7789340045,20462689242793896,2.40639901531589,1.01650823124183e-20,19.9928891002838,32.1173872780919,Inf,4.89215110948636e-28,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR2516625","ERR2516625","lineage4.1.1.3","pe","Peru","pnca_p.leu120pro","A","H","LEU","LA120","pnca_complex.pdb"
|
|
"L120P","L4","PZA","L","L120",120,"P",NA,"XDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",17.55,-1.644,-2.181,7.59698,-4.748,-1.51,79,85,-1.142,9,9,0,0,"helix",-0.533333333333334,8.07,0.0018686215322696,254.917127071823,3820001.12561286,Inf,120.509921037495,16,16,0,0,16,0,0,0,0,2,2,2,-2,0,0,0,0,0,4,-4,-2,8,0,2,4,-0.416413373860182,-0.563565891472868,0.276698548212035,-0.809548167092924,-0.395287958115183,0.831578947368421,-0.940691927512356,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.201,-1.124,"9:9","147/150","F:V:L",15.1557612752458,0.885234541058746,105.002771503186,0.14433677376588,15316.7789340045,20462689242793896,2.40639901531589,1.01650823124183e-20,19.9928891002838,32.1173872780919,Inf,4.89215110948636e-28,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR1034825","ERR1034825","lineage4.3.4.2","pt","Portugal","pnca_p.leu120pro","A","H","LEU","LA120","pnca_complex.pdb"
|
|
"L120P","L4","PZA","L","L120",120,"P",1,"XDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",17.55,-1.644,-2.181,7.59698,-4.748,-1.51,79,85,-1.142,9,9,0,0,"helix",-0.533333333333334,8.07,0.0018686215322696,254.917127071823,3820001.12561286,Inf,120.509921037495,16,16,0,0,16,0,0,0,0,2,2,2,-2,0,0,0,0,0,4,-4,-2,8,0,2,4,-0.416413373860182,-0.563565891472868,0.276698548212035,-0.809548167092924,-0.395287958115183,0.831578947368421,-0.940691927512356,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.201,-1.124,"9:9","147/150","F:V:L",15.1557612752458,0.885234541058746,105.002771503186,0.14433677376588,15316.7789340045,20462689242793896,2.40639901531589,1.01650823124183e-20,19.9928891002838,32.1173872780919,Inf,4.89215110948636e-28,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR2516901","ERR2516901","lineage4.3.4.2","gb","UK","pnca_p.leu120pro","A","H","LEU","LA120","pnca_complex.pdb"
|
|
"L120P","L4","PZA","L","L120",120,"P",NA,"XDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",17.55,-1.644,-2.181,7.59698,-4.748,-1.51,79,85,-1.142,9,9,0,0,"helix",-0.533333333333334,8.07,0.0018686215322696,254.917127071823,3820001.12561286,Inf,120.509921037495,16,16,0,0,16,0,0,0,0,2,2,2,-2,0,0,0,0,0,4,-4,-2,8,0,2,4,-0.416413373860182,-0.563565891472868,0.276698548212035,-0.809548167092924,-0.395287958115183,0.831578947368421,-0.940691927512356,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.201,-1.124,"9:9","147/150","F:V:L",15.1557612752458,0.885234541058746,105.002771503186,0.14433677376588,15316.7789340045,20462689242793896,2.40639901531589,1.01650823124183e-20,19.9928891002838,32.1173872780919,Inf,4.89215110948636e-28,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR1034859","ERR1034859","lineage4.3.4.2","pt","Portugal","pnca_p.leu120pro","A","H","LEU","LA120","pnca_complex.pdb"
|
|
"L120P","L4","PZA","L","L120",120,"P",NA,"MDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",17.55,-1.644,-2.181,7.59698,-4.748,-1.51,79,85,-1.142,9,9,0,0,"helix",-0.533333333333334,8.07,0.0018686215322696,254.917127071823,3820001.12561286,Inf,120.509921037495,16,16,0,0,16,0,0,0,0,2,2,2,-2,0,0,0,0,0,4,-4,-2,8,0,2,4,-0.416413373860182,-0.563565891472868,0.276698548212035,-0.809548167092924,-0.395287958115183,0.831578947368421,-0.940691927512356,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.201,-1.124,"9:9","147/150","F:V:L",15.1557612752458,0.885234541058746,105.002771503186,0.14433677376588,15316.7789340045,20462689242793896,2.40639901531589,1.01650823124183e-20,19.9928891002838,32.1173872780919,Inf,4.89215110948636e-28,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR3148154","ERR3148154","lineage4.1.1.3","mx","Mexico","pnca_p.leu120pro","A","H","LEU","LA120","pnca_complex.pdb"
|
|
"L120P","L4","PZA","L","L120",120,"P",NA,"XDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",17.55,-1.644,-2.181,7.59698,-4.748,-1.51,79,85,-1.142,9,9,0,0,"helix",-0.533333333333334,8.07,0.0018686215322696,254.917127071823,3820001.12561286,Inf,120.509921037495,16,16,0,0,16,0,0,0,0,2,2,2,-2,0,0,0,0,0,4,-4,-2,8,0,2,4,-0.416413373860182,-0.563565891472868,0.276698548212035,-0.809548167092924,-0.395287958115183,0.831578947368421,-0.940691927512356,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.201,-1.124,"9:9","147/150","F:V:L",15.1557612752458,0.885234541058746,105.002771503186,0.14433677376588,15316.7789340045,20462689242793896,2.40639901531589,1.01650823124183e-20,19.9928891002838,32.1173872780919,Inf,4.89215110948636e-28,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR1035195","ERR1035195","lineage4.3.4.2","pt","Portugal","pnca_p.leu120pro","A","H","LEU","LA120","pnca_complex.pdb"
|
|
"L120P","L4","PZA","L","L120",120,"P",NA,"XDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",17.55,-1.644,-2.181,7.59698,-4.748,-1.51,79,85,-1.142,9,9,0,0,"helix",-0.533333333333334,8.07,0.0018686215322696,254.917127071823,3820001.12561286,Inf,120.509921037495,16,16,0,0,16,0,0,0,0,2,2,2,-2,0,0,0,0,0,4,-4,-2,8,0,2,4,-0.416413373860182,-0.563565891472868,0.276698548212035,-0.809548167092924,-0.395287958115183,0.831578947368421,-0.940691927512356,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.201,-1.124,"9:9","147/150","F:V:L",15.1557612752458,0.885234541058746,105.002771503186,0.14433677376588,15316.7789340045,20462689242793896,2.40639901531589,1.01650823124183e-20,19.9928891002838,32.1173872780919,Inf,4.89215110948636e-28,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR1034910","ERR1034910","lineage4.3.4.2","pt","Portugal","pnca_p.leu120pro","A","H","LEU","LA120","pnca_complex.pdb"
|
|
"L120P","L4","PZA","L","L120",120,"P",NA,"XDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",17.55,-1.644,-2.181,7.59698,-4.748,-1.51,79,85,-1.142,9,9,0,0,"helix",-0.533333333333334,8.07,0.0018686215322696,254.917127071823,3820001.12561286,Inf,120.509921037495,16,16,0,0,16,0,0,0,0,2,2,2,-2,0,0,0,0,0,4,-4,-2,8,0,2,4,-0.416413373860182,-0.563565891472868,0.276698548212035,-0.809548167092924,-0.395287958115183,0.831578947368421,-0.940691927512356,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.201,-1.124,"9:9","147/150","F:V:L",15.1557612752458,0.885234541058746,105.002771503186,0.14433677376588,15316.7789340045,20462689242793896,2.40639901531589,1.01650823124183e-20,19.9928891002838,32.1173872780919,Inf,4.89215110948636e-28,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR275199","ERR275199","lineage4.3.4.2","pt","Portugal","pnca_p.leu120pro","A","H","LEU","LA120","pnca_complex.pdb"
|
|
"L120P","L4","PZA","L","L120",120,"P",NA,"MDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",17.55,-1.644,-2.181,7.59698,-4.748,-1.51,79,85,-1.142,9,9,0,0,"helix",-0.533333333333334,8.07,0.0018686215322696,254.917127071823,3820001.12561286,Inf,120.509921037495,16,16,0,0,16,0,0,0,0,2,2,2,-2,0,0,0,0,0,4,-4,-2,8,0,2,4,-0.416413373860182,-0.563565891472868,0.276698548212035,-0.809548167092924,-0.395287958115183,0.831578947368421,-0.940691927512356,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.201,-1.124,"9:9","147/150","F:V:L",15.1557612752458,0.885234541058746,105.002771503186,0.14433677376588,15316.7789340045,20462689242793896,2.40639901531589,1.01650823124183e-20,19.9928891002838,32.1173872780919,Inf,4.89215110948636e-28,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR3148217","ERR3148217","lineage4.1.1.3","mx","Mexico","pnca_p.leu120pro","A","H","LEU","LA120","pnca_complex.pdb"
|
|
"L120P","L4","PZA","L","L120",120,"P",NA,"MDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",17.55,-1.644,-2.181,7.59698,-4.748,-1.51,79,85,-1.142,9,9,0,0,"helix",-0.533333333333334,8.07,0.0018686215322696,254.917127071823,3820001.12561286,Inf,120.509921037495,16,16,0,0,16,0,0,0,0,2,2,2,-2,0,0,0,0,0,4,-4,-2,8,0,2,4,-0.416413373860182,-0.563565891472868,0.276698548212035,-0.809548167092924,-0.395287958115183,0.831578947368421,-0.940691927512356,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.201,-1.124,"9:9","147/150","F:V:L",15.1557612752458,0.885234541058746,105.002771503186,0.14433677376588,15316.7789340045,20462689242793896,2.40639901531589,1.01650823124183e-20,19.9928891002838,32.1173872780919,Inf,4.89215110948636e-28,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR3148201","ERR3148201","lineage4.1.1.3","mx","Mexico","pnca_p.leu120pro","A","H","LEU","LA120","pnca_complex.pdb"
|
|
"L120P","L4","PZA","L","L120",120,"P",NA,"XDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",17.55,-1.644,-2.181,7.59698,-4.748,-1.51,79,85,-1.142,9,9,0,0,"helix",-0.533333333333334,8.07,0.0018686215322696,254.917127071823,3820001.12561286,Inf,120.509921037495,16,16,0,0,16,0,0,0,0,2,2,2,-2,0,0,0,0,0,4,-4,-2,8,0,2,4,-0.416413373860182,-0.563565891472868,0.276698548212035,-0.809548167092924,-0.395287958115183,0.831578947368421,-0.940691927512356,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.201,-1.124,"9:9","147/150","F:V:L",15.1557612752458,0.885234541058746,105.002771503186,0.14433677376588,15316.7789340045,20462689242793896,2.40639901531589,1.01650823124183e-20,19.9928891002838,32.1173872780919,Inf,4.89215110948636e-28,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR1035253","ERR1035253","lineage4.3.4.2","pt","Portugal","pnca_p.leu120pro","A","H","LEU","LA120","pnca_complex.pdb"
|
|
"L120P","L4","PZA","L","L120",120,"P",1,"XDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",17.55,-1.644,-2.181,7.59698,-4.748,-1.51,79,85,-1.142,9,9,0,0,"helix",-0.533333333333334,8.07,0.0018686215322696,254.917127071823,3820001.12561286,Inf,120.509921037495,16,16,0,0,16,0,0,0,0,2,2,2,-2,0,0,0,0,0,4,-4,-2,8,0,2,4,-0.416413373860182,-0.563565891472868,0.276698548212035,-0.809548167092924,-0.395287958115183,0.831578947368421,-0.940691927512356,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.201,-1.124,"9:9","147/150","F:V:L",15.1557612752458,0.885234541058746,105.002771503186,0.14433677376588,15316.7789340045,20462689242793896,2.40639901531589,1.01650823124183e-20,19.9928891002838,32.1173872780919,Inf,4.89215110948636e-28,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR2864234","ERR2864234","lineage4.3.4.2","pt","Portugal","pnca_p.leu120pro","A","H","LEU","LA120","pnca_complex.pdb"
|
|
"L120P","L4","PZA","L","L120",120,"P",NA,"XDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",17.55,-1.644,-2.181,7.59698,-4.748,-1.51,79,85,-1.142,9,9,0,0,"helix",-0.533333333333334,8.07,0.0018686215322696,254.917127071823,3820001.12561286,Inf,120.509921037495,16,16,0,0,16,0,0,0,0,2,2,2,-2,0,0,0,0,0,4,-4,-2,8,0,2,4,-0.416413373860182,-0.563565891472868,0.276698548212035,-0.809548167092924,-0.395287958115183,0.831578947368421,-0.940691927512356,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.201,-1.124,"9:9","147/150","F:V:L",15.1557612752458,0.885234541058746,105.002771503186,0.14433677376588,15316.7789340045,20462689242793896,2.40639901531589,1.01650823124183e-20,19.9928891002838,32.1173872780919,Inf,4.89215110948636e-28,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR3148175","ERR3148175","lineage4.1.1.3","mx","Mexico","pnca_p.leu120pro","A","H","LEU","LA120","pnca_complex.pdb"
|
|
"L120P","L4","PZA","L","L120",120,"P",1,"XDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",17.55,-1.644,-2.181,7.59698,-4.748,-1.51,79,85,-1.142,9,9,0,0,"helix",-0.533333333333334,8.07,0.0018686215322696,254.917127071823,3820001.12561286,Inf,120.509921037495,16,16,0,0,16,0,0,0,0,2,2,2,-2,0,0,0,0,0,4,-4,-2,8,0,2,4,-0.416413373860182,-0.563565891472868,0.276698548212035,-0.809548167092924,-0.395287958115183,0.831578947368421,-0.940691927512356,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.201,-1.124,"9:9","147/150","F:V:L",15.1557612752458,0.885234541058746,105.002771503186,0.14433677376588,15316.7789340045,20462689242793896,2.40639901531589,1.01650823124183e-20,19.9928891002838,32.1173872780919,Inf,4.89215110948636e-28,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR1034905","ERR1034905","lineage4.3.4.2","pt","Portugal","pnca_p.leu120pro","A","H","LEU","LA120","pnca_complex.pdb"
|
|
"L120P","L4","PZA","L","L120",120,"P",1,"XDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",17.55,-1.644,-2.181,7.59698,-4.748,-1.51,79,85,-1.142,9,9,0,0,"helix",-0.533333333333334,8.07,0.0018686215322696,254.917127071823,3820001.12561286,Inf,120.509921037495,16,16,0,0,16,0,0,0,0,2,2,2,-2,0,0,0,0,0,4,-4,-2,8,0,2,4,-0.416413373860182,-0.563565891472868,0.276698548212035,-0.809548167092924,-0.395287958115183,0.831578947368421,-0.940691927512356,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.201,-1.124,"9:9","147/150","F:V:L",15.1557612752458,0.885234541058746,105.002771503186,0.14433677376588,15316.7789340045,20462689242793896,2.40639901531589,1.01650823124183e-20,19.9928891002838,32.1173872780919,Inf,4.89215110948636e-28,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR2516313","ERR2516313","lineage4.3.4.2","be","Belgium","pnca_p.leu120pro","A","H","LEU","LA120","pnca_complex.pdb"
|
|
"L120P","L4","PZA","L","L120",120,"P",NA,"XDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",17.55,-1.644,-2.181,7.59698,-4.748,-1.51,79,85,-1.142,9,9,0,0,"helix",-0.533333333333334,8.07,0.0018686215322696,254.917127071823,3820001.12561286,Inf,120.509921037495,16,16,0,0,16,0,0,0,0,2,2,2,-2,0,0,0,0,0,4,-4,-2,8,0,2,4,-0.416413373860182,-0.563565891472868,0.276698548212035,-0.809548167092924,-0.395287958115183,0.831578947368421,-0.940691927512356,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.201,-1.124,"9:9","147/150","F:V:L",15.1557612752458,0.885234541058746,105.002771503186,0.14433677376588,15316.7789340045,20462689242793896,2.40639901531589,1.01650823124183e-20,19.9928891002838,32.1173872780919,Inf,4.89215110948636e-28,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR1034906","ERR1034906","lineage4.3.4.2","pt","Portugal","pnca_p.leu120pro","A","H","LEU","LA120","pnca_complex.pdb"
|
|
"L120P","L4","PZA","L","L120",120,"P",1,"XDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",17.55,-1.644,-2.181,7.59698,-4.748,-1.51,79,85,-1.142,9,9,0,0,"helix",-0.533333333333334,8.07,0.0018686215322696,254.917127071823,3820001.12561286,Inf,120.509921037495,16,16,0,0,16,0,0,0,0,2,2,2,-2,0,0,0,0,0,4,-4,-2,8,0,2,4,-0.416413373860182,-0.563565891472868,0.276698548212035,-0.809548167092924,-0.395287958115183,0.831578947368421,-0.940691927512356,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.201,-1.124,"9:9","147/150","F:V:L",15.1557612752458,0.885234541058746,105.002771503186,0.14433677376588,15316.7789340045,20462689242793896,2.40639901531589,1.01650823124183e-20,19.9928891002838,32.1173872780919,Inf,4.89215110948636e-28,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR2516709","ERR2516709","lineage4.1.1.3","pe","Peru","pnca_p.leu120pro","A","H","LEU","LA120","pnca_complex.pdb"
|
|
"L120P","L4","PZA","L","L120",120,"P",NA,"MDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",17.55,-1.644,-2.181,7.59698,-4.748,-1.51,79,85,-1.142,9,9,0,0,"helix",-0.533333333333334,8.07,0.0018686215322696,254.917127071823,3820001.12561286,Inf,120.509921037495,16,16,0,0,16,0,0,0,0,2,2,2,-2,0,0,0,0,0,4,-4,-2,8,0,2,4,-0.416413373860182,-0.563565891472868,0.276698548212035,-0.809548167092924,-0.395287958115183,0.831578947368421,-0.940691927512356,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.201,-1.124,"9:9","147/150","F:V:L",15.1557612752458,0.885234541058746,105.002771503186,0.14433677376588,15316.7789340045,20462689242793896,2.40639901531589,1.01650823124183e-20,19.9928891002838,32.1173872780919,Inf,4.89215110948636e-28,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR3148151","ERR3148151","lineage4.1.1.3","mx","Mexico","pnca_p.leu120pro","A","H","LEU","LA120","pnca_complex.pdb"
|
|
"L120P","L4","PZA","L","L120",120,"P",NA,"XDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",17.55,-1.644,-2.181,7.59698,-4.748,-1.51,79,85,-1.142,9,9,0,0,"helix",-0.533333333333334,8.07,0.0018686215322696,254.917127071823,3820001.12561286,Inf,120.509921037495,16,16,0,0,16,0,0,0,0,2,2,2,-2,0,0,0,0,0,4,-4,-2,8,0,2,4,-0.416413373860182,-0.563565891472868,0.276698548212035,-0.809548167092924,-0.395287958115183,0.831578947368421,-0.940691927512356,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.201,-1.124,"9:9","147/150","F:V:L",15.1557612752458,0.885234541058746,105.002771503186,0.14433677376588,15316.7789340045,20462689242793896,2.40639901531589,1.01650823124183e-20,19.9928891002838,32.1173872780919,Inf,4.89215110948636e-28,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR1034837","ERR1034837","lineage4.3.4.2","pt","Portugal","pnca_p.leu120pro","A","H","LEU","LA120","pnca_complex.pdb"
|
|
"L120P","L4","PZA","L","L120",120,"P",1,"Pre-XDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",17.55,-1.644,-2.181,7.59698,-4.748,-1.51,79,85,-1.142,9,9,0,0,"helix",-0.533333333333334,8.07,0.0018686215322696,254.917127071823,3820001.12561286,Inf,120.509921037495,16,16,0,0,16,0,0,0,0,2,2,2,-2,0,0,0,0,0,4,-4,-2,8,0,2,4,-0.416413373860182,-0.563565891472868,0.276698548212035,-0.809548167092924,-0.395287958115183,0.831578947368421,-0.940691927512356,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.201,-1.124,"9:9","147/150","F:V:L",15.1557612752458,0.885234541058746,105.002771503186,0.14433677376588,15316.7789340045,20462689242793896,2.40639901531589,1.01650823124183e-20,19.9928891002838,32.1173872780919,Inf,4.89215110948636e-28,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR2516543","ERR2516543","lineage4.1.1.3","pe","Peru","pnca_p.leu120pro","A","H","LEU","LA120","pnca_complex.pdb"
|
|
"L120P","L4","PZA","L","L120",120,"P",1,"XDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",17.55,-1.644,-2.181,7.59698,-4.748,-1.51,79,85,-1.142,9,9,0,0,"helix",-0.533333333333334,8.07,0.0018686215322696,254.917127071823,3820001.12561286,Inf,120.509921037495,16,16,0,0,16,0,0,0,0,2,2,2,-2,0,0,0,0,0,4,-4,-2,8,0,2,4,-0.416413373860182,-0.563565891472868,0.276698548212035,-0.809548167092924,-0.395287958115183,0.831578947368421,-0.940691927512356,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.201,-1.124,"9:9","147/150","F:V:L",15.1557612752458,0.885234541058746,105.002771503186,0.14433677376588,15316.7789340045,20462689242793896,2.40639901531589,1.01650823124183e-20,19.9928891002838,32.1173872780919,Inf,4.89215110948636e-28,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR2864287","ERR2864287","lineage4.3.4.2","pt","Portugal","pnca_p.leu120pro","A","H","LEU","LA120","pnca_complex.pdb"
|
|
"L120P","L4","PZA","L","L120",120,"P",NA,"XDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",17.55,-1.644,-2.181,7.59698,-4.748,-1.51,79,85,-1.142,9,9,0,0,"helix",-0.533333333333334,8.07,0.0018686215322696,254.917127071823,3820001.12561286,Inf,120.509921037495,16,16,0,0,16,0,0,0,0,2,2,2,-2,0,0,0,0,0,4,-4,-2,8,0,2,4,-0.416413373860182,-0.563565891472868,0.276698548212035,-0.809548167092924,-0.395287958115183,0.831578947368421,-0.940691927512356,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.201,-1.124,"9:9","147/150","F:V:L",15.1557612752458,0.885234541058746,105.002771503186,0.14433677376588,15316.7789340045,20462689242793896,2.40639901531589,1.01650823124183e-20,19.9928891002838,32.1173872780919,Inf,4.89215110948636e-28,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR1034867","ERR1034867","lineage4.3.4.2","pt","Portugal","pnca_p.leu120pro","A","H","LEU","LA120","pnca_complex.pdb"
|
|
"L120P","L4","PZA","L","L120",120,"P",1,"XDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",17.55,-1.644,-2.181,7.59698,-4.748,-1.51,79,85,-1.142,9,9,0,0,"helix",-0.533333333333334,8.07,0.0018686215322696,254.917127071823,3820001.12561286,Inf,120.509921037495,16,16,0,0,16,0,0,0,0,2,2,2,-2,0,0,0,0,0,4,-4,-2,8,0,2,4,-0.416413373860182,-0.563565891472868,0.276698548212035,-0.809548167092924,-0.395287958115183,0.831578947368421,-0.940691927512356,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.201,-1.124,"9:9","147/150","F:V:L",15.1557612752458,0.885234541058746,105.002771503186,0.14433677376588,15316.7789340045,20462689242793896,2.40639901531589,1.01650823124183e-20,19.9928891002838,32.1173872780919,Inf,4.89215110948636e-28,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR2864216","ERR2864216","lineage4.3.4.2","pt","Portugal","pnca_p.leu120pro","A","H","LEU","LA120","pnca_complex.pdb"
|
|
"L120P","L4","PZA","L","L120",120,"P",1,"XDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",17.55,-1.644,-2.181,7.59698,-4.748,-1.51,79,85,-1.142,9,9,0,0,"helix",-0.533333333333334,8.07,0.0018686215322696,254.917127071823,3820001.12561286,Inf,120.509921037495,16,16,0,0,16,0,0,0,0,2,2,2,-2,0,0,0,0,0,4,-4,-2,8,0,2,4,-0.416413373860182,-0.563565891472868,0.276698548212035,-0.809548167092924,-0.395287958115183,0.831578947368421,-0.940691927512356,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.201,-1.124,"9:9","147/150","F:V:L",15.1557612752458,0.885234541058746,105.002771503186,0.14433677376588,15316.7789340045,20462689242793896,2.40639901531589,1.01650823124183e-20,19.9928891002838,32.1173872780919,Inf,4.89215110948636e-28,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR1035214","ERR1035214","lineage4.3.4.2","pt","Portugal","pnca_p.leu120pro","A","H","LEU","LA120","pnca_complex.pdb"
|
|
"L120P","L4","PZA","L","L120",120,"P",1,"XDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",17.55,-1.644,-2.181,7.59698,-4.748,-1.51,79,85,-1.142,9,9,0,0,"helix",-0.533333333333334,8.07,0.0018686215322696,254.917127071823,3820001.12561286,Inf,120.509921037495,16,16,0,0,16,0,0,0,0,2,2,2,-2,0,0,0,0,0,4,-4,-2,8,0,2,4,-0.416413373860182,-0.563565891472868,0.276698548212035,-0.809548167092924,-0.395287958115183,0.831578947368421,-0.940691927512356,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.201,-1.124,"9:9","147/150","F:V:L",15.1557612752458,0.885234541058746,105.002771503186,0.14433677376588,15316.7789340045,20462689242793896,2.40639901531589,1.01650823124183e-20,19.9928891002838,32.1173872780919,Inf,4.89215110948636e-28,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR1035207","ERR1035207","lineage4.3.4.2","pt","Portugal","pnca_p.leu120pro","A","H","LEU","LA120","pnca_complex.pdb"
|
|
"L120P","L4","PZA","L","L120",120,"P",1,"XDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",17.55,-1.644,-2.181,7.59698,-4.748,-1.51,79,85,-1.142,9,9,0,0,"helix",-0.533333333333334,8.07,0.0018686215322696,254.917127071823,3820001.12561286,Inf,120.509921037495,16,16,0,0,16,0,0,0,0,2,2,2,-2,0,0,0,0,0,4,-4,-2,8,0,2,4,-0.416413373860182,-0.563565891472868,0.276698548212035,-0.809548167092924,-0.395287958115183,0.831578947368421,-0.940691927512356,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.201,-1.124,"9:9","147/150","F:V:L",15.1557612752458,0.885234541058746,105.002771503186,0.14433677376588,15316.7789340045,20462689242793896,2.40639901531589,1.01650823124183e-20,19.9928891002838,32.1173872780919,Inf,4.89215110948636e-28,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR2516664","ERR2516664","lineage4.1.1.3","pe","Peru","pnca_p.leu120pro","A","H","LEU","LA120","pnca_complex.pdb"
|
|
"L120P","L4","PZA","L","L120",120,"P",1,"XDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",17.55,-1.644,-2.181,7.59698,-4.748,-1.51,79,85,-1.142,9,9,0,0,"helix",-0.533333333333334,8.07,0.0018686215322696,254.917127071823,3820001.12561286,Inf,120.509921037495,16,16,0,0,16,0,0,0,0,2,2,2,-2,0,0,0,0,0,4,-4,-2,8,0,2,4,-0.416413373860182,-0.563565891472868,0.276698548212035,-0.809548167092924,-0.395287958115183,0.831578947368421,-0.940691927512356,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.201,-1.124,"9:9","147/150","F:V:L",15.1557612752458,0.885234541058746,105.002771503186,0.14433677376588,15316.7789340045,20462689242793896,2.40639901531589,1.01650823124183e-20,19.9928891002838,32.1173872780919,Inf,4.89215110948636e-28,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR2864293","ERR2864293","lineage4.3.4.2","pt","Portugal","pnca_p.leu120pro","A","H","LEU","LA120","pnca_complex.pdb"
|
|
"L120P","L4","PZA","L","L120",120,"P",NA,"XDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",17.55,-1.644,-2.181,7.59698,-4.748,-1.51,79,85,-1.142,9,9,0,0,"helix",-0.533333333333334,8.07,0.0018686215322696,254.917127071823,3820001.12561286,Inf,120.509921037495,16,16,0,0,16,0,0,0,0,2,2,2,-2,0,0,0,0,0,4,-4,-2,8,0,2,4,-0.416413373860182,-0.563565891472868,0.276698548212035,-0.809548167092924,-0.395287958115183,0.831578947368421,-0.940691927512356,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.201,-1.124,"9:9","147/150","F:V:L",15.1557612752458,0.885234541058746,105.002771503186,0.14433677376588,15316.7789340045,20462689242793896,2.40639901531589,1.01650823124183e-20,19.9928891002838,32.1173872780919,Inf,4.89215110948636e-28,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR1034829","ERR1034829","lineage4.3.4.2","pt","Portugal","pnca_p.leu120pro","A","H","LEU","LA120","pnca_complex.pdb"
|
|
"L120P","L4","PZA","L","L120",120,"P",NA,"MDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",17.55,-1.644,-2.181,7.59698,-4.748,-1.51,79,85,-1.142,9,9,0,0,"helix",-0.533333333333334,8.07,0.0018686215322696,254.917127071823,3820001.12561286,Inf,120.509921037495,16,16,0,0,16,0,0,0,0,2,2,2,-2,0,0,0,0,0,4,-4,-2,8,0,2,4,-0.416413373860182,-0.563565891472868,0.276698548212035,-0.809548167092924,-0.395287958115183,0.831578947368421,-0.940691927512356,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.201,-1.124,"9:9","147/150","F:V:L",15.1557612752458,0.885234541058746,105.002771503186,0.14433677376588,15316.7789340045,20462689242793896,2.40639901531589,1.01650823124183e-20,19.9928891002838,32.1173872780919,Inf,4.89215110948636e-28,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR3148198","ERR3148198","lineage4.1.1.3","mx","Mexico","pnca_p.leu120pro","A","H","LEU","LA120","pnca_complex.pdb"
|
|
"L120P","L4","PZA","L","L120",120,"P",NA,"XDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",17.55,-1.644,-2.181,7.59698,-4.748,-1.51,79,85,-1.142,9,9,0,0,"helix",-0.533333333333334,8.07,0.0018686215322696,254.917127071823,3820001.12561286,Inf,120.509921037495,16,16,0,0,16,0,0,0,0,2,2,2,-2,0,0,0,0,0,4,-4,-2,8,0,2,4,-0.416413373860182,-0.563565891472868,0.276698548212035,-0.809548167092924,-0.395287958115183,0.831578947368421,-0.940691927512356,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.201,-1.124,"9:9","147/150","F:V:L",15.1557612752458,0.885234541058746,105.002771503186,0.14433677376588,15316.7789340045,20462689242793896,2.40639901531589,1.01650823124183e-20,19.9928891002838,32.1173872780919,Inf,4.89215110948636e-28,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR1034870","ERR1034870","lineage4.3.4.2","pt","Portugal","pnca_p.leu120pro","A","H","LEU","LA120","pnca_complex.pdb"
|
|
"L120P","L4","PZA","L","L120",120,"P",1,"XDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",17.55,-1.644,-2.181,7.59698,-4.748,-1.51,79,85,-1.142,9,9,0,0,"helix",-0.533333333333334,8.07,0.0018686215322696,254.917127071823,3820001.12561286,Inf,120.509921037495,16,16,0,0,16,0,0,0,0,2,2,2,-2,0,0,0,0,0,4,-4,-2,8,0,2,4,-0.416413373860182,-0.563565891472868,0.276698548212035,-0.809548167092924,-0.395287958115183,0.831578947368421,-0.940691927512356,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.201,-1.124,"9:9","147/150","F:V:L",15.1557612752458,0.885234541058746,105.002771503186,0.14433677376588,15316.7789340045,20462689242793896,2.40639901531589,1.01650823124183e-20,19.9928891002838,32.1173872780919,Inf,4.89215110948636e-28,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR2516573","ERR2516573","lineage4.1.1.3","pe","Peru","pnca_p.leu120pro","A","H","LEU","LA120","pnca_complex.pdb"
|
|
"L120P","L4","PZA","L","L120",120,"P",1,"XDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",17.55,-1.644,-2.181,7.59698,-4.748,-1.51,79,85,-1.142,9,9,0,0,"helix",-0.533333333333334,8.07,0.0018686215322696,254.917127071823,3820001.12561286,Inf,120.509921037495,16,16,0,0,16,0,0,0,0,2,2,2,-2,0,0,0,0,0,4,-4,-2,8,0,2,4,-0.416413373860182,-0.563565891472868,0.276698548212035,-0.809548167092924,-0.395287958115183,0.831578947368421,-0.940691927512356,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.201,-1.124,"9:9","147/150","F:V:L",15.1557612752458,0.885234541058746,105.002771503186,0.14433677376588,15316.7789340045,20462689242793896,2.40639901531589,1.01650823124183e-20,19.9928891002838,32.1173872780919,Inf,4.89215110948636e-28,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR2516728","ERR2516728","lineage4.1.1.3","pe","Peru","pnca_p.leu120pro","A","H","LEU","LA120","pnca_complex.pdb"
|
|
"L120P","L4","PZA","L","L120",120,"P",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",17.55,-1.644,-2.181,7.59698,-4.748,-1.51,79,85,-1.142,9,9,0,0,"helix",-0.533333333333334,8.07,0.0018686215322696,254.917127071823,3820001.12561286,Inf,120.509921037495,16,16,0,0,16,0,0,0,0,2,2,2,-2,0,0,0,0,0,4,-4,-2,8,0,2,4,-0.416413373860182,-0.563565891472868,0.276698548212035,-0.809548167092924,-0.395287958115183,0.831578947368421,-0.940691927512356,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.201,-1.124,"9:9","147/150","F:V:L",15.1557612752458,0.885234541058746,105.002771503186,0.14433677376588,15316.7789340045,20462689242793896,2.40639901531589,1.01650823124183e-20,19.9928891002838,32.1173872780919,Inf,4.89215110948636e-28,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR3148222","ERR3148222","lineage4.1.1.3","mx","Mexico","pnca_p.leu120pro","A","H","LEU","LA120","pnca_complex.pdb"
|
|
"L120P","L4","PZA","L","L120",120,"P",1,"XDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",17.55,-1.644,-2.181,7.59698,-4.748,-1.51,79,85,-1.142,9,9,0,0,"helix",-0.533333333333334,8.07,0.0018686215322696,254.917127071823,3820001.12561286,Inf,120.509921037495,16,16,0,0,16,0,0,0,0,2,2,2,-2,0,0,0,0,0,4,-4,-2,8,0,2,4,-0.416413373860182,-0.563565891472868,0.276698548212035,-0.809548167092924,-0.395287958115183,0.831578947368421,-0.940691927512356,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.201,-1.124,"9:9","147/150","F:V:L",15.1557612752458,0.885234541058746,105.002771503186,0.14433677376588,15316.7789340045,20462689242793896,2.40639901531589,1.01650823124183e-20,19.9928891002838,32.1173872780919,Inf,4.89215110948636e-28,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR2864298","ERR2864298","lineage4.3.4.2","pt","Portugal","pnca_p.leu120pro","A","H","LEU","LA120","pnca_complex.pdb"
|
|
"L120P","L4","PZA","L","L120",120,"P",1,"XDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",17.55,-1.644,-2.181,7.59698,-4.748,-1.51,79,85,-1.142,9,9,0,0,"helix",-0.533333333333334,8.07,0.0018686215322696,254.917127071823,3820001.12561286,Inf,120.509921037495,16,16,0,0,16,0,0,0,0,2,2,2,-2,0,0,0,0,0,4,-4,-2,8,0,2,4,-0.416413373860182,-0.563565891472868,0.276698548212035,-0.809548167092924,-0.395287958115183,0.831578947368421,-0.940691927512356,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.201,-1.124,"9:9","147/150","F:V:L",15.1557612752458,0.885234541058746,105.002771503186,0.14433677376588,15316.7789340045,20462689242793896,2.40639901531589,1.01650823124183e-20,19.9928891002838,32.1173872780919,Inf,4.89215110948636e-28,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR2864276","ERR2864276","lineage4.3.4.2","pt","Portugal","pnca_p.leu120pro","A","H","LEU","LA120","pnca_complex.pdb"
|
|
"L120P","L4","PZA","L","L120",120,"P",1,"XDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",17.55,-1.644,-2.181,7.59698,-4.748,-1.51,79,85,-1.142,9,9,0,0,"helix",-0.533333333333334,8.07,0.0018686215322696,254.917127071823,3820001.12561286,Inf,120.509921037495,16,16,0,0,16,0,0,0,0,2,2,2,-2,0,0,0,0,0,4,-4,-2,8,0,2,4,-0.416413373860182,-0.563565891472868,0.276698548212035,-0.809548167092924,-0.395287958115183,0.831578947368421,-0.940691927512356,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.201,-1.124,"9:9","147/150","F:V:L",15.1557612752458,0.885234541058746,105.002771503186,0.14433677376588,15316.7789340045,20462689242793896,2.40639901531589,1.01650823124183e-20,19.9928891002838,32.1173872780919,Inf,4.89215110948636e-28,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR2516990","ERR2516990","lineage4.3.4.2","gb","UK","pnca_p.leu120pro","A","H","LEU","LA120","pnca_complex.pdb"
|
|
"L120P","L4","PZA","L","L120",120,"P",1,"XDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",17.55,-1.644,-2.181,7.59698,-4.748,-1.51,79,85,-1.142,9,9,0,0,"helix",-0.533333333333334,8.07,0.0018686215322696,254.917127071823,3820001.12561286,Inf,120.509921037495,16,16,0,0,16,0,0,0,0,2,2,2,-2,0,0,0,0,0,4,-4,-2,8,0,2,4,-0.416413373860182,-0.563565891472868,0.276698548212035,-0.809548167092924,-0.395287958115183,0.831578947368421,-0.940691927512356,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.201,-1.124,"9:9","147/150","F:V:L",15.1557612752458,0.885234541058746,105.002771503186,0.14433677376588,15316.7789340045,20462689242793896,2.40639901531589,1.01650823124183e-20,19.9928891002838,32.1173872780919,Inf,4.89215110948636e-28,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR1034903","ERR1034903","lineage4.3.4.2","pt","Portugal","pnca_p.leu120pro","A","H","LEU","LA120","pnca_complex.pdb"
|
|
"L120P","L4","PZA","L","L120",120,"P",NA,"MDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",17.55,-1.644,-2.181,7.59698,-4.748,-1.51,79,85,-1.142,9,9,0,0,"helix",-0.533333333333334,8.07,0.0018686215322696,254.917127071823,3820001.12561286,Inf,120.509921037495,16,16,0,0,16,0,0,0,0,2,2,2,-2,0,0,0,0,0,4,-4,-2,8,0,2,4,-0.416413373860182,-0.563565891472868,0.276698548212035,-0.809548167092924,-0.395287958115183,0.831578947368421,-0.940691927512356,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.201,-1.124,"9:9","147/150","F:V:L",15.1557612752458,0.885234541058746,105.002771503186,0.14433677376588,15316.7789340045,20462689242793896,2.40639901531589,1.01650823124183e-20,19.9928891002838,32.1173872780919,Inf,4.89215110948636e-28,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR3148172","ERR3148172","lineage4.1.1.3","mx","Mexico","pnca_p.leu120pro","A","H","LEU","LA120","pnca_complex.pdb"
|
|
"L120P","L4","PZA","L","L120",120,"P",NA,"MDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",17.55,-1.644,-2.181,7.59698,-4.748,-1.51,79,85,-1.142,9,9,0,0,"helix",-0.533333333333334,8.07,0.0018686215322696,254.917127071823,3820001.12561286,Inf,120.509921037495,16,16,0,0,16,0,0,0,0,2,2,2,-2,0,0,0,0,0,4,-4,-2,8,0,2,4,-0.416413373860182,-0.563565891472868,0.276698548212035,-0.809548167092924,-0.395287958115183,0.831578947368421,-0.940691927512356,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.201,-1.124,"9:9","147/150","F:V:L",15.1557612752458,0.885234541058746,105.002771503186,0.14433677376588,15316.7789340045,20462689242793896,2.40639901531589,1.01650823124183e-20,19.9928891002838,32.1173872780919,Inf,4.89215110948636e-28,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR3148219","ERR3148219","lineage4.1.1.3","mx","Mexico","pnca_p.leu120pro","A","H","LEU","LA120","pnca_complex.pdb"
|
|
"L120P","L4","PZA","L","L120",120,"P",NA,"MDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",17.55,-1.644,-2.181,7.59698,-4.748,-1.51,79,85,-1.142,9,9,0,0,"helix",-0.533333333333334,8.07,0.0018686215322696,254.917127071823,3820001.12561286,Inf,120.509921037495,16,16,0,0,16,0,0,0,0,2,2,2,-2,0,0,0,0,0,4,-4,-2,8,0,2,4,-0.416413373860182,-0.563565891472868,0.276698548212035,-0.809548167092924,-0.395287958115183,0.831578947368421,-0.940691927512356,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.201,-1.124,"9:9","147/150","F:V:L",15.1557612752458,0.885234541058746,105.002771503186,0.14433677376588,15316.7789340045,20462689242793896,2.40639901531589,1.01650823124183e-20,19.9928891002838,32.1173872780919,Inf,4.89215110948636e-28,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR3148173","ERR3148173","lineage4.1.1.3","mx","Mexico","pnca_p.leu120pro","A","H","LEU","LA120","pnca_complex.pdb"
|
|
"L120P","L4","PZA","L","L120",120,"P",1,"XDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",17.55,-1.644,-2.181,7.59698,-4.748,-1.51,79,85,-1.142,9,9,0,0,"helix",-0.533333333333334,8.07,0.0018686215322696,254.917127071823,3820001.12561286,Inf,120.509921037495,16,16,0,0,16,0,0,0,0,2,2,2,-2,0,0,0,0,0,4,-4,-2,8,0,2,4,-0.416413373860182,-0.563565891472868,0.276698548212035,-0.809548167092924,-0.395287958115183,0.831578947368421,-0.940691927512356,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.201,-1.124,"9:9","147/150","F:V:L",15.1557612752458,0.885234541058746,105.002771503186,0.14433677376588,15316.7789340045,20462689242793896,2.40639901531589,1.01650823124183e-20,19.9928891002838,32.1173872780919,Inf,4.89215110948636e-28,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR2516752","ERR2516752","lineage4.3.4.2","gb","UK","pnca_p.leu120pro","A","H","LEU","LA120","pnca_complex.pdb"
|
|
"L120P","L4","PZA","L","L120",120,"P",NA,"XDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",17.55,-1.644,-2.181,7.59698,-4.748,-1.51,79,85,-1.142,9,9,0,0,"helix",-0.533333333333334,8.07,0.0018686215322696,254.917127071823,3820001.12561286,Inf,120.509921037495,16,16,0,0,16,0,0,0,0,2,2,2,-2,0,0,0,0,0,4,-4,-2,8,0,2,4,-0.416413373860182,-0.563565891472868,0.276698548212035,-0.809548167092924,-0.395287958115183,0.831578947368421,-0.940691927512356,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.201,-1.124,"9:9","147/150","F:V:L",15.1557612752458,0.885234541058746,105.002771503186,0.14433677376588,15316.7789340045,20462689242793896,2.40639901531589,1.01650823124183e-20,19.9928891002838,32.1173872780919,Inf,4.89215110948636e-28,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR275202","ERR275202","lineage4.3.4.2","pt","Portugal","pnca_p.leu120pro","A","H","LEU","LA120","pnca_complex.pdb"
|
|
"L120P","L4","PZA","L","L120",120,"P",NA,"MDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",17.55,-1.644,-2.181,7.59698,-4.748,-1.51,79,85,-1.142,9,9,0,0,"helix",-0.533333333333334,8.07,0.0018686215322696,254.917127071823,3820001.12561286,Inf,120.509921037495,16,16,0,0,16,0,0,0,0,2,2,2,-2,0,0,0,0,0,4,-4,-2,8,0,2,4,-0.416413373860182,-0.563565891472868,0.276698548212035,-0.809548167092924,-0.395287958115183,0.831578947368421,-0.940691927512356,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.201,-1.124,"9:9","147/150","F:V:L",15.1557612752458,0.885234541058746,105.002771503186,0.14433677376588,15316.7789340045,20462689242793896,2.40639901531589,1.01650823124183e-20,19.9928891002838,32.1173872780919,Inf,4.89215110948636e-28,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR3148176","ERR3148176","lineage4.1.1.3","mx","Mexico","pnca_p.leu120pro","A","H","LEU","LA120","pnca_complex.pdb"
|
|
"L120P","L4","PZA","L","L120",120,"P",NA,"MDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",17.55,-1.644,-2.181,7.59698,-4.748,-1.51,79,85,-1.142,9,9,0,0,"helix",-0.533333333333334,8.07,0.0018686215322696,254.917127071823,3820001.12561286,Inf,120.509921037495,16,16,0,0,16,0,0,0,0,2,2,2,-2,0,0,0,0,0,4,-4,-2,8,0,2,4,-0.416413373860182,-0.563565891472868,0.276698548212035,-0.809548167092924,-0.395287958115183,0.831578947368421,-0.940691927512356,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.201,-1.124,"9:9","147/150","F:V:L",15.1557612752458,0.885234541058746,105.002771503186,0.14433677376588,15316.7789340045,20462689242793896,2.40639901531589,1.01650823124183e-20,19.9928891002838,32.1173872780919,Inf,4.89215110948636e-28,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR1035299","ERR1035299","lineage4.1.2.1","br","Brazil","pnca_p.leu120pro","A","H","LEU","LA120","pnca_complex.pdb"
|
|
"L120P","L1","PZA","L","L120",120,"P",1,"MDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",17.55,-1.644,-2.181,7.59698,-4.748,-1.51,79,85,-1.142,9,9,0,0,"helix",-0.533333333333334,8.07,0.0018686215322696,254.917127071823,3820001.12561286,Inf,120.509921037495,16,16,0,0,16,0,0,0,0,2,2,2,-2,0,0,0,0,0,4,-4,-2,8,0,2,4,-0.416413373860182,-0.563565891472868,0.276698548212035,-0.809548167092924,-0.395287958115183,0.831578947368421,-0.940691927512356,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.201,-1.124,"9:9","147/150","F:V:L",15.1557612752458,0.885234541058746,105.002771503186,0.14433677376588,15316.7789340045,20462689242793896,2.40639901531589,1.01650823124183e-20,19.9928891002838,32.1173872780919,Inf,4.89215110948636e-28,"lineage1","dr_mutations_pyrazinamide","PRO",0,"SRR6367399","SRR6367399","lineage1.1.2","au","Australia","pnca_p.leu120pro","A","H","LEU","LA120","pnca_complex.pdb"
|
|
"L120P","L4","PZA","L","L120",120,"P",NA,"MDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",17.55,-1.644,-2.181,7.59698,-4.748,-1.51,79,85,-1.142,9,9,0,0,"helix",-0.533333333333334,8.07,0.0018686215322696,254.917127071823,3820001.12561286,Inf,120.509921037495,16,16,0,0,16,0,0,0,0,2,2,2,-2,0,0,0,0,0,4,-4,-2,8,0,2,4,-0.416413373860182,-0.563565891472868,0.276698548212035,-0.809548167092924,-0.395287958115183,0.831578947368421,-0.940691927512356,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.201,-1.124,"9:9","147/150","F:V:L",15.1557612752458,0.885234541058746,105.002771503186,0.14433677376588,15316.7789340045,20462689242793896,2.40639901531589,1.01650823124183e-20,19.9928891002838,32.1173872780919,Inf,4.89215110948636e-28,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR3148183","ERR3148183","lineage4.1.1.3","mx","Mexico","pnca_p.leu120pro","A","H","LEU","LA120","pnca_complex.pdb"
|
|
"L120P","L4","PZA","L","L120",120,"P",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",17.55,-1.644,-2.181,7.59698,-4.748,-1.51,79,85,-1.142,9,9,0,0,"helix",-0.533333333333334,8.07,0.0018686215322696,254.917127071823,3820001.12561286,Inf,120.509921037495,16,16,0,0,16,0,0,0,0,2,2,2,-2,0,0,0,0,0,4,-4,-2,8,0,2,4,-0.416413373860182,-0.563565891472868,0.276698548212035,-0.809548167092924,-0.395287958115183,0.831578947368421,-0.940691927512356,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.201,-1.124,"9:9","147/150","F:V:L",15.1557612752458,0.885234541058746,105.002771503186,0.14433677376588,15316.7789340045,20462689242793896,2.40639901531589,1.01650823124183e-20,19.9928891002838,32.1173872780919,Inf,4.89215110948636e-28,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR3148197","ERR3148197","lineage4.1.1.3","mx","Mexico","pnca_p.leu120pro","A","H","LEU","LA120","pnca_complex.pdb"
|
|
"L120P","L4","PZA","L","L120",120,"P",1,"XDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",17.55,-1.644,-2.181,7.59698,-4.748,-1.51,79,85,-1.142,9,9,0,0,"helix",-0.533333333333334,8.07,0.0018686215322696,254.917127071823,3820001.12561286,Inf,120.509921037495,16,16,0,0,16,0,0,0,0,2,2,2,-2,0,0,0,0,0,4,-4,-2,8,0,2,4,-0.416413373860182,-0.563565891472868,0.276698548212035,-0.809548167092924,-0.395287958115183,0.831578947368421,-0.940691927512356,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.201,-1.124,"9:9","147/150","F:V:L",15.1557612752458,0.885234541058746,105.002771503186,0.14433677376588,15316.7789340045,20462689242793896,2.40639901531589,1.01650823124183e-20,19.9928891002838,32.1173872780919,Inf,4.89215110948636e-28,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR2864267","ERR2864267","lineage4.3.4.2","pt","Portugal","pnca_p.leu120pro","A","H","LEU","LA120","pnca_complex.pdb"
|
|
"L120P","L4","PZA","L","L120",120,"P",1,"XDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",17.55,-1.644,-2.181,7.59698,-4.748,-1.51,79,85,-1.142,9,9,0,0,"helix",-0.533333333333334,8.07,0.0018686215322696,254.917127071823,3820001.12561286,Inf,120.509921037495,16,16,0,0,16,0,0,0,0,2,2,2,-2,0,0,0,0,0,4,-4,-2,8,0,2,4,-0.416413373860182,-0.563565891472868,0.276698548212035,-0.809548167092924,-0.395287958115183,0.831578947368421,-0.940691927512356,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.201,-1.124,"9:9","147/150","F:V:L",15.1557612752458,0.885234541058746,105.002771503186,0.14433677376588,15316.7789340045,20462689242793896,2.40639901531589,1.01650823124183e-20,19.9928891002838,32.1173872780919,Inf,4.89215110948636e-28,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR1034814","ERR1034814","lineage4.3.4.2","pt","Portugal","pnca_p.leu120pro","A","H","LEU","LA120","pnca_complex.pdb"
|
|
"L120P","L4","PZA","L","L120",120,"P",NA,"XDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",17.55,-1.644,-2.181,7.59698,-4.748,-1.51,79,85,-1.142,9,9,0,0,"helix",-0.533333333333334,8.07,0.0018686215322696,254.917127071823,3820001.12561286,Inf,120.509921037495,16,16,0,0,16,0,0,0,0,2,2,2,-2,0,0,0,0,0,4,-4,-2,8,0,2,4,-0.416413373860182,-0.563565891472868,0.276698548212035,-0.809548167092924,-0.395287958115183,0.831578947368421,-0.940691927512356,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.201,-1.124,"9:9","147/150","F:V:L",15.1557612752458,0.885234541058746,105.002771503186,0.14433677376588,15316.7789340045,20462689242793896,2.40639901531589,1.01650823124183e-20,19.9928891002838,32.1173872780919,Inf,4.89215110948636e-28,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR1034888","ERR1034888","lineage4.3.4.2","pt","Portugal","pnca_p.leu120pro","A","H","LEU","LA120","pnca_complex.pdb"
|
|
"L120P","L2","PZA","L","L120",120,"P",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",17.55,-1.644,-2.181,7.59698,-4.748,-1.51,79,85,-1.142,9,9,0,0,"helix",-0.533333333333334,8.07,0.0018686215322696,254.917127071823,3820001.12561286,Inf,120.509921037495,16,16,0,0,16,0,0,0,0,2,2,2,-2,0,0,0,0,0,4,-4,-2,8,0,2,4,-0.416413373860182,-0.563565891472868,0.276698548212035,-0.809548167092924,-0.395287958115183,0.831578947368421,-0.940691927512356,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.201,-1.124,"9:9","147/150","F:V:L",15.1557612752458,0.885234541058746,105.002771503186,0.14433677376588,15316.7789340045,20462689242793896,2.40639901531589,1.01650823124183e-20,19.9928891002838,32.1173872780919,Inf,4.89215110948636e-28,"lineage2","dr_mutations_pyrazinamide","PRO",0,"ETB0052","SRR6257101","lineage2.2.1","ru","Russia:Leningrad Region","pnca_p.leu120pro","A","H","LEU","LA120","pnca_complex.pdb"
|
|
"L120P","L4","PZA","L","L120",120,"P",1,"XDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",17.55,-1.644,-2.181,7.59698,-4.748,-1.51,79,85,-1.142,9,9,0,0,"helix",-0.533333333333334,8.07,0.0018686215322696,254.917127071823,3820001.12561286,Inf,120.509921037495,16,16,0,0,16,0,0,0,0,2,2,2,-2,0,0,0,0,0,4,-4,-2,8,0,2,4,-0.416413373860182,-0.563565891472868,0.276698548212035,-0.809548167092924,-0.395287958115183,0.831578947368421,-0.940691927512356,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.201,-1.124,"9:9","147/150","F:V:L",15.1557612752458,0.885234541058746,105.002771503186,0.14433677376588,15316.7789340045,20462689242793896,2.40639901531589,1.01650823124183e-20,19.9928891002838,32.1173872780919,Inf,4.89215110948636e-28,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR2516525","ERR2516525","lineage4.1.1.3","pe","Peru","pnca_p.leu120pro","A","H","LEU","LA120","pnca_complex.pdb"
|
|
"L120P","L4","PZA","L","L120",120,"P",1,"XDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",17.55,-1.644,-2.181,7.59698,-4.748,-1.51,79,85,-1.142,9,9,0,0,"helix",-0.533333333333334,8.07,0.0018686215322696,254.917127071823,3820001.12561286,Inf,120.509921037495,16,16,0,0,16,0,0,0,0,2,2,2,-2,0,0,0,0,0,4,-4,-2,8,0,2,4,-0.416413373860182,-0.563565891472868,0.276698548212035,-0.809548167092924,-0.395287958115183,0.831578947368421,-0.940691927512356,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.201,-1.124,"9:9","147/150","F:V:L",15.1557612752458,0.885234541058746,105.002771503186,0.14433677376588,15316.7789340045,20462689242793896,2.40639901531589,1.01650823124183e-20,19.9928891002838,32.1173872780919,Inf,4.89215110948636e-28,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR1035196","ERR1035196","lineage4.3.4.2","pt","Portugal","pnca_p.leu120pro","A","H","LEU","LA120","pnca_complex.pdb"
|
|
"L120P","L4","PZA","L","L120",120,"P",NA,"MDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",17.55,-1.644,-2.181,7.59698,-4.748,-1.51,79,85,-1.142,9,9,0,0,"helix",-0.533333333333334,8.07,0.0018686215322696,254.917127071823,3820001.12561286,Inf,120.509921037495,16,16,0,0,16,0,0,0,0,2,2,2,-2,0,0,0,0,0,4,-4,-2,8,0,2,4,-0.416413373860182,-0.563565891472868,0.276698548212035,-0.809548167092924,-0.395287958115183,0.831578947368421,-0.940691927512356,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.201,-1.124,"9:9","147/150","F:V:L",15.1557612752458,0.885234541058746,105.002771503186,0.14433677376588,15316.7789340045,20462689242793896,2.40639901531589,1.01650823124183e-20,19.9928891002838,32.1173872780919,Inf,4.89215110948636e-28,"lineage4","dr_mutations_pyrazinamide","PRO",0,"NG1","ERR1679585","lineage4.6.2.2","ng","Nigeria","pnca_p.leu120pro","A","H","LEU","LA120","pnca_complex.pdb"
|
|
"L120P","L4","PZA","L","L120",120,"P",NA,"XDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",17.55,-1.644,-2.181,7.59698,-4.748,-1.51,79,85,-1.142,9,9,0,0,"helix",-0.533333333333334,8.07,0.0018686215322696,254.917127071823,3820001.12561286,Inf,120.509921037495,16,16,0,0,16,0,0,0,0,2,2,2,-2,0,0,0,0,0,4,-4,-2,8,0,2,4,-0.416413373860182,-0.563565891472868,0.276698548212035,-0.809548167092924,-0.395287958115183,0.831578947368421,-0.940691927512356,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.201,-1.124,"9:9","147/150","F:V:L",15.1557612752458,0.885234541058746,105.002771503186,0.14433677376588,15316.7789340045,20462689242793896,2.40639901531589,1.01650823124183e-20,19.9928891002838,32.1173872780919,Inf,4.89215110948636e-28,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR775379","ERR775379","lineage4.1.1.3","pe","","pnca_p.leu120pro","A","H","LEU","LA120","pnca_complex.pdb"
|
|
"L120R","L3","PZA","L","L120",120,"R",1,"Pre-XDR","OM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",17.55,-0.772,-2.51,5.6624,-4.716,-1.93,74,85,-1.142,9,9,0,0,"helix",-0.533333333333334,8.07,0.0005030904125341,12.1451137320977,12.1450773794065,12.1416664151504,11.0019205274607,-44,-32,0,-2,-30,0,0,0,0,0,0,0,0,0,0,0,0,-8,0,0,-13,-8,0,-12,-4,-0.195542046605876,-0.648578811369509,0.206236933544096,-0.804092071611253,-0.505235602094241,0.778947368421053,-0.940691927512356,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.201,-1.124,"9:9","147/150","F:V:L",2.4969239337312,0.0028293218857323,0.83629495944555,2.98569769616526,2.61610833083038,84.8371270839259,1.08440158608155,0.0022516005975125,2.64750864476206,1.98635523014012,127.719946645636,0.0009101752788745,"lineage3","other_mutations_pyrazinamide","ARG",0,"ERR3335799","ERR3335799","lineage3","pk","Pakistan","pnca_p.leu120arg","A","H","LEU","LA120","pnca_complex.pdb"
|
|
"L120R","L3","PZA","L","L120",120,"R",1,"Pre-XDR","OM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",17.55,-0.772,-2.51,5.6624,-4.716,-1.93,74,85,-1.142,9,9,0,0,"helix",-0.533333333333334,8.07,0.0005030904125341,12.1451137320977,12.1450773794065,12.1416664151504,11.0019205274607,-44,-32,0,-2,-30,0,0,0,0,0,0,0,0,0,0,0,0,-8,0,0,-13,-8,0,-12,-4,-0.195542046605876,-0.648578811369509,0.206236933544096,-0.804092071611253,-0.505235602094241,0.778947368421053,-0.940691927512356,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.201,-1.124,"9:9","147/150","F:V:L",2.4969239337312,0.0028293218857323,0.83629495944555,2.98569769616526,2.61610833083038,84.8371270839259,1.08440158608155,0.0022516005975125,2.64750864476206,1.98635523014012,127.719946645636,0.0009101752788745,"lineage3","other_mutations_pyrazinamide","ARG",0,"ERR2510385","ERR2510385","lineage3","pk","Pakistan","pnca_p.leu120arg","A","H","LEU","LA120","pnca_complex.pdb"
|
|
"L120R","L4","PZA","L","L120",120,"R",NA,"MDR","OM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",17.55,-0.772,-2.51,5.6624,-4.716,-1.93,74,85,-1.142,9,9,0,0,"helix",-0.533333333333334,8.07,0.0005030904125341,12.1451137320977,12.1450773794065,12.1416664151504,11.0019205274607,-44,-32,0,-2,-30,0,0,0,0,0,0,0,0,0,0,0,0,-8,0,0,-13,-8,0,-12,-4,-0.195542046605876,-0.648578811369509,0.206236933544096,-0.804092071611253,-0.505235602094241,0.778947368421053,-0.940691927512356,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.201,-1.124,"9:9","147/150","F:V:L",2.4969239337312,0.0028293218857323,0.83629495944555,2.98569769616526,2.61610833083038,84.8371270839259,1.08440158608155,0.0022516005975125,2.64750864476206,1.98635523014012,127.719946645636,0.0009101752788745,"lineage4","other_mutations_pyrazinamide","ARG",0,"ERR751439","ERR751439","lineage4.3.4.2","pe","","pnca_p.leu120arg","A","H","LEU","LA120","pnca_complex.pdb"
|
|
"L120R","L3","PZA","L","L120",120,"R",1,"Pre-XDR","OM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",17.55,-0.772,-2.51,5.6624,-4.716,-1.93,74,85,-1.142,9,9,0,0,"helix",-0.533333333333334,8.07,0.0005030904125341,12.1451137320977,12.1450773794065,12.1416664151504,11.0019205274607,-44,-32,0,-2,-30,0,0,0,0,0,0,0,0,0,0,0,0,-8,0,0,-13,-8,0,-12,-4,-0.195542046605876,-0.648578811369509,0.206236933544096,-0.804092071611253,-0.505235602094241,0.778947368421053,-0.940691927512356,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.201,-1.124,"9:9","147/150","F:V:L",2.4969239337312,0.0028293218857323,0.83629495944555,2.98569769616526,2.61610833083038,84.8371270839259,1.08440158608155,0.0022516005975125,2.64750864476206,1.98635523014012,127.719946645636,0.0009101752788745,"lineage3","other_mutations_pyrazinamide","ARG",0,"ERR3335792","ERR3335792","lineage3","pk","Pakistan","pnca_p.leu120arg","A","H","LEU","LA120","pnca_complex.pdb"
|
|
"L120R","L2","PZA","L","L120",120,"R",NA,"Pre-XDR","OM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",17.55,-0.772,-2.51,5.6624,-4.716,-1.93,74,85,-1.142,9,9,0,0,"helix",-0.533333333333334,8.07,0.0005030904125341,12.1451137320977,12.1450773794065,12.1416664151504,11.0019205274607,-44,-32,0,-2,-30,0,0,0,0,0,0,0,0,0,0,0,0,-8,0,0,-13,-8,0,-12,-4,-0.195542046605876,-0.648578811369509,0.206236933544096,-0.804092071611253,-0.505235602094241,0.778947368421053,-0.940691927512356,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.201,-1.124,"9:9","147/150","F:V:L",2.4969239337312,0.0028293218857323,0.83629495944555,2.98569769616526,2.61610833083038,84.8371270839259,1.08440158608155,0.0022516005975125,2.64750864476206,1.98635523014012,127.719946645636,0.0009101752788745,"lineage2","other_mutations_pyrazinamide","ARG",0,"SAMN02584612","SRR1166179_SRR1169181","lineage2.2.1","md","Moldova","pnca_p.leu120arg","A","H","LEU","LA120","pnca_complex.pdb"
|
|
"L120R","L3","PZA","L","L120",120,"R",1,"Pre-XDR","OM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",17.55,-0.772,-2.51,5.6624,-4.716,-1.93,74,85,-1.142,9,9,0,0,"helix",-0.533333333333334,8.07,0.0005030904125341,12.1451137320977,12.1450773794065,12.1416664151504,11.0019205274607,-44,-32,0,-2,-30,0,0,0,0,0,0,0,0,0,0,0,0,-8,0,0,-13,-8,0,-12,-4,-0.195542046605876,-0.648578811369509,0.206236933544096,-0.804092071611253,-0.505235602094241,0.778947368421053,-0.940691927512356,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.201,-1.124,"9:9","147/150","F:V:L",2.4969239337312,0.0028293218857323,0.83629495944555,2.98569769616526,2.61610833083038,84.8371270839259,1.08440158608155,0.0022516005975125,2.64750864476206,1.98635523014012,127.719946645636,0.0009101752788745,"lineage3","other_mutations_pyrazinamide","ARG",0,"ERR3335789","ERR3335789","lineage3","pk","Pakistan","pnca_p.leu120arg","A","H","LEU","LA120","pnca_complex.pdb"
|
|
"L120R","L2","PZA","L","L120",120,"R",1,"Pre-MDR","OM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",17.55,-0.772,-2.51,5.6624,-4.716,-1.93,74,85,-1.142,9,9,0,0,"helix",-0.533333333333334,8.07,0.0005030904125341,12.1451137320977,12.1450773794065,12.1416664151504,11.0019205274607,-44,-32,0,-2,-30,0,0,0,0,0,0,0,0,0,0,0,0,-8,0,0,-13,-8,0,-12,-4,-0.195542046605876,-0.648578811369509,0.206236933544096,-0.804092071611253,-0.505235602094241,0.778947368421053,-0.940691927512356,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.201,-1.124,"9:9","147/150","F:V:L",2.4969239337312,0.0028293218857323,0.83629495944555,2.98569769616526,2.61610833083038,84.8371270839259,1.08440158608155,0.0022516005975125,2.64750864476206,1.98635523014012,127.719946645636,0.0009101752788745,"lineage2","other_mutations_pyrazinamide","ARG",0,"ERR551575","ERR551575","lineage2.2.1","uz","Uzbekistan","pnca_p.leu120arg","A","H","LEU","LA120","pnca_complex.pdb"
|
|
"L120R","L3","PZA","L","L120",120,"R",0,"Pre-XDR","OM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",17.55,-0.772,-2.51,5.6624,-4.716,-1.93,74,85,-1.142,9,9,0,0,"helix",-0.533333333333334,8.07,0.0005030904125341,12.1451137320977,12.1450773794065,12.1416664151504,11.0019205274607,-44,-32,0,-2,-30,0,0,0,0,0,0,0,0,0,0,0,0,-8,0,0,-13,-8,0,-12,-4,-0.195542046605876,-0.648578811369509,0.206236933544096,-0.804092071611253,-0.505235602094241,0.778947368421053,-0.940691927512356,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.201,-1.124,"9:9","147/150","F:V:L",2.4969239337312,0.0028293218857323,0.83629495944555,2.98569769616526,2.61610833083038,84.8371270839259,1.08440158608155,0.0022516005975125,2.64750864476206,1.98635523014012,127.719946645636,0.0009101752788745,"lineage3","other_mutations_pyrazinamide","ARG",0,"ERR2516839","ERR2516839","lineage3","gb","UK","pnca_p.leu120arg","A","H","LEU","LA120","pnca_complex.pdb"
|
|
"L120R","L2","PZA","L","L120",120,"R",NA,"MDR","OM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",17.55,-0.772,-2.51,5.6624,-4.716,-1.93,74,85,-1.142,9,9,0,0,"helix",-0.533333333333334,8.07,0.0005030904125341,12.1451137320977,12.1450773794065,12.1416664151504,11.0019205274607,-44,-32,0,-2,-30,0,0,0,0,0,0,0,0,0,0,0,0,-8,0,0,-13,-8,0,-12,-4,-0.195542046605876,-0.648578811369509,0.206236933544096,-0.804092071611253,-0.505235602094241,0.778947368421053,-0.940691927512356,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.201,-1.124,"9:9","147/150","F:V:L",2.4969239337312,0.0028293218857323,0.83629495944555,2.98569769616526,2.61610833083038,84.8371270839259,1.08440158608155,0.0022516005975125,2.64750864476206,1.98635523014012,127.719946645636,0.0009101752788745,"lineage2","other_mutations_pyrazinamide","ARG",0,"ERR1023520","ERR1023520","lineage2.2.1","","","pnca_p.leu120arg","A","H","LEU","LA120","pnca_complex.pdb"
|
|
"L120R","L3","PZA","L","L120",120,"R",0,"Pre-XDR","OM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",17.55,-0.772,-2.51,5.6624,-4.716,-1.93,74,85,-1.142,9,9,0,0,"helix",-0.533333333333334,8.07,0.0005030904125341,12.1451137320977,12.1450773794065,12.1416664151504,11.0019205274607,-44,-32,0,-2,-30,0,0,0,0,0,0,0,0,0,0,0,0,-8,0,0,-13,-8,0,-12,-4,-0.195542046605876,-0.648578811369509,0.206236933544096,-0.804092071611253,-0.505235602094241,0.778947368421053,-0.940691927512356,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.201,-1.124,"9:9","147/150","F:V:L",2.4969239337312,0.0028293218857323,0.83629495944555,2.98569769616526,2.61610833083038,84.8371270839259,1.08440158608155,0.0022516005975125,2.64750864476206,1.98635523014012,127.719946645636,0.0009101752788745,"lineage3","other_mutations_pyrazinamide","ARG",0,"ERR2516871","ERR2516871","lineage3","gb","UK","pnca_p.leu120arg","A","H","LEU","LA120","pnca_complex.pdb"
|
|
"L120R","L4","PZA","L","L120",120,"R",NA,"MDR","OM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",17.55,-0.772,-2.51,5.6624,-4.716,-1.93,74,85,-1.142,9,9,0,0,"helix",-0.533333333333334,8.07,0.0005030904125341,12.1451137320977,12.1450773794065,12.1416664151504,11.0019205274607,-44,-32,0,-2,-30,0,0,0,0,0,0,0,0,0,0,0,0,-8,0,0,-13,-8,0,-12,-4,-0.195542046605876,-0.648578811369509,0.206236933544096,-0.804092071611253,-0.505235602094241,0.778947368421053,-0.940691927512356,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.201,-1.124,"9:9","147/150","F:V:L",2.4969239337312,0.0028293218857323,0.83629495944555,2.98569769616526,2.61610833083038,84.8371270839259,1.08440158608155,0.0022516005975125,2.64750864476206,1.98635523014012,127.719946645636,0.0009101752788745,"lineage4","other_mutations_pyrazinamide","ARG",0,"ERR751463","ERR751463","lineage4.3.4.2","pe","","pnca_p.leu120arg","A","H","LEU","LA120","pnca_complex.pdb"
|
|
"R121P","L2","PZA","R","R121",121,"P",NA,"Pre-XDR","DM","hydrophilic","hydrophilic","basic","non-polar","pos","non-polar",22.533,-1.047,-0.46,4.90155,-1.076,-0.11,77,85,0.506,3,3,125,0.456204379562044,"helix",-1.4,3.76,7.18700589334483e-05,9.70142977291842,188179.926264617,Inf,0.763784339928386,40,20,0,2,18,0,0,0,0,4,2,2,0,0,0,0,0,0,4,-3,-2,4,0,4,0,-0.265197568389058,-0.118863049095607,0.178525120375294,-0.183461210571185,-0.0287958115183246,0.810526315789474,0.162179487179487,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.225,0.59,"4:3","147/150","D:T:A:S:G:L:N:C:R:K:I:H:E:Q",12.1451538387264,0.919026337424231,119.468044436227,0.101660271548259,5.01153666063191e-06,NA,0.986835744238421,0.170978870202674,0.767057556984365,0.124324963210678,Inf,0.382146811758261,"lineage2","dr_mutations_pyrazinamide","PRO",0,"ERR1213849","ERR1213849","lineage2.2.2","kr","South Korea","pnca_p.arg121pro","A","H","ARG","RA121","pnca_complex.pdb"
|
|
"R121P","L2","PZA","R","R121",121,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","basic","non-polar","pos","non-polar",22.533,-1.047,-0.46,4.90155,-1.076,-0.11,77,85,0.506,3,3,125,0.456204379562044,"helix",-1.4,3.76,7.18700589334483e-05,9.70142977291842,188179.926264617,Inf,0.763784339928386,40,20,0,2,18,0,0,0,0,4,2,2,0,0,0,0,0,0,4,-3,-2,4,0,4,0,-0.265197568389058,-0.118863049095607,0.178525120375294,-0.183461210571185,-0.0287958115183246,0.810526315789474,0.162179487179487,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.225,0.59,"4:3","147/150","D:T:A:S:G:L:N:C:R:K:I:H:E:Q",12.1451538387264,0.919026337424231,119.468044436227,0.101660271548259,5.01153666063191e-06,NA,0.986835744238421,0.170978870202674,0.767057556984365,0.124324963210678,Inf,0.382146811758261,"lineage2","dr_mutations_pyrazinamide","PRO",0,"ERR2516730","ERR2516730","lineage2.2.1","nl","Netherlands","pnca_p.arg121pro","A","H","ARG","RA121","pnca_complex.pdb"
|
|
"R121Q","L1","PZA","R","R121",121,"Q",0,"Other","OM","hydrophilic","hydrophilic","basic","neutral","pos","polar",22.533,-0.674,-0.169,1.41722,-0.286,-0.53,1,53,0.506,3,3,125,0.456204379562044,"helix",-1.4,3.76,7.18700589334483e-05,2.42412778478352,0.0001249735077034,0,1.03410070803344e-29,22,18,0,2,16,0,0,0,0,0,0,0,0,0,0,0,0,-1,0,0,-1,-2,0,-2,2,-0.170719351570415,-0.0436692506459948,0.0516182373123347,-0.0487638533674339,-0.138743455497382,0.0105263157894737,0.162179487179487,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.225,0.59,"4:3","147/150","D:T:A:S:G:L:N:C:R:K:I:H:E:Q",-8.98740878149641,0.940032862253633,119.46804443549,-0.0752285585987758,NA,4692673.51080988,0.384555509373631,1,0,0,188.544222231268,0.999999999999997,"lineage1","other_mutations_pyrazinamide","GLN",0,"SAMEA2297105,ERS389492,ERR400534","ERR400534","lineage1.2.1","gb","United Kingdom","pnca_p.arg121gln","A","H","ARG","RA121","pnca_complex.pdb"
|
|
"R121W","L2","PZA","R","R121",121,"W",NA,"Sensitive","OM","hydrophilic","hydrophobic","basic","non-polar","pos","non-polar",22.533,-0.426,-0.538,1.95975,-0.442,-0.5,70,85,0.506,3,3,125,0.456204379562044,"helix",-1.4,3.76,NA,NA,NA,NA,NA,6,18,0,2,16,0,0,0,0,2,0,2,0,0,0,0,0,0,0,0,0,-4,0,-6,-2,-0.10790273556231,-0.139018087855297,0.0713783608563582,-0.0753623188405797,-0.130890052356021,0.736842105263158,0.162179487179487,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.225,0.59,"4:3","147/150","D:T:A:S:G:L:N:C:R:K:I:H:E:Q",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage2","other_mutations_pyrazinamide","TRP",0,"ERR234139","ERR234139","lineage2.2.1","cn","China","pnca_p.arg121trp","A","H","ARG","RA121","pnca_complex.pdb"
|
|
"Q122R","L4","PZA","Q","Q122",122,"R",NA,"Sensitive","OM","hydrophilic","hydrophilic","neutral","basic","polar","pos",24.683,-0.114,0.113,-1.69455,-0.152,-0.16,-41,72,1.334,1,1,132,0.586666666666667,"loop",-4.16666666666667,3.49,NA,NA,NA,NA,NA,-24,-1,0,0,-1,0,0,0,0,2,0,-2,0,0,0,0,0,2,0,3,-1,2,0,0,2,-0.0288753799392097,0.0960884353741496,-0.325799815427209,-0.0259164535379369,-0.0418848167539267,-0.440860215053763,0.427564102564103,"Destabilising","Stabilising","Stabilising","Destabilising","Destabilising","neutral",0.842,1.712,"2:1","147/150","D:T:S:M:A:G:K:R:N:Q:H:E:Y",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage4","other_mutations_pyrazinamide","ARG",0,"ERR2229385","ERR2229385","lineage4.8","dk","","pnca_p.gln122arg","A","T","GLN","QA122","pnca_complex.pdb"
|
|
"Q122R","L4","PZA","Q","Q122",122,"R",NA,"Other","OM","hydrophilic","hydrophilic","neutral","basic","polar","pos",24.683,-0.114,0.113,-1.69455,-0.152,-0.16,-41,72,1.334,1,1,132,0.586666666666667,"loop",-4.16666666666667,3.49,NA,NA,NA,NA,NA,-24,-1,0,0,-1,0,0,0,0,2,0,-2,0,0,0,0,0,2,0,3,-1,2,0,0,2,-0.0288753799392097,0.0960884353741496,-0.325799815427209,-0.0259164535379369,-0.0418848167539267,-0.440860215053763,0.427564102564103,"Destabilising","Stabilising","Stabilising","Destabilising","Destabilising","neutral",0.842,1.712,"2:1","147/150","D:T:S:M:A:G:K:R:N:Q:H:E:Y",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage4","other_mutations_pyrazinamide","ARG",0,"ERR2229698","ERR2229698","lineage4.8","dk","","pnca_p.gln122arg","A","T","GLN","QA122","pnca_complex.pdb"
|
|
"Q122R","L4","PZA","Q","Q122",122,"R",NA,"Pre-MDR","OM","hydrophilic","hydrophilic","neutral","basic","polar","pos",24.683,-0.114,0.113,-1.69455,-0.152,-0.16,-41,72,1.334,1,1,132,0.586666666666667,"loop",-4.16666666666667,3.49,NA,NA,NA,NA,NA,-24,-1,0,0,-1,0,0,0,0,2,0,-2,0,0,0,0,0,2,0,3,-1,2,0,0,2,-0.0288753799392097,0.0960884353741496,-0.325799815427209,-0.0259164535379369,-0.0418848167539267,-0.440860215053763,0.427564102564103,"Destabilising","Stabilising","Stabilising","Destabilising","Destabilising","neutral",0.842,1.712,"2:1","147/150","D:T:S:M:A:G:K:R:N:Q:H:E:Y",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage4","other_mutations_pyrazinamide","ARG",0,"SRR6325447","SRR6325447","lineage4.3;lineage4.1.1","us","","pnca_p.gln122arg","A","T","GLN","QA122","pnca_complex.pdb"
|
|
"Q122R","L4","PZA","Q","Q122",122,"R",NA,"Sensitive","OM","hydrophilic","hydrophilic","neutral","basic","polar","pos",24.683,-0.114,0.113,-1.69455,-0.152,-0.16,-41,72,1.334,1,1,132,0.586666666666667,"loop",-4.16666666666667,3.49,NA,NA,NA,NA,NA,-24,-1,0,0,-1,0,0,0,0,2,0,-2,0,0,0,0,0,2,0,3,-1,2,0,0,2,-0.0288753799392097,0.0960884353741496,-0.325799815427209,-0.0259164535379369,-0.0418848167539267,-0.440860215053763,0.427564102564103,"Destabilising","Stabilising","Stabilising","Destabilising","Destabilising","neutral",0.842,1.712,"2:1","147/150","D:T:S:M:A:G:K:R:N:Q:H:E:Y",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage4","other_mutations_pyrazinamide","ARG",0,"ERR2229273","ERR2229273","lineage4.8","dk","","pnca_p.gln122arg","A","T","GLN","QA122","pnca_complex.pdb"
|
|
"Q122R","L3;L4","PZA","Q","Q122",122,"R",NA,"Pre-MDR","OM","hydrophilic","hydrophilic","neutral","basic","polar","pos",24.683,-0.114,0.113,-1.69455,-0.152,-0.16,-41,72,1.334,1,1,132,0.586666666666667,"loop",-4.16666666666667,3.49,NA,NA,NA,NA,NA,-24,-1,0,0,-1,0,0,0,0,2,0,-2,0,0,0,0,0,2,0,3,-1,2,0,0,2,-0.0288753799392097,0.0960884353741496,-0.325799815427209,-0.0259164535379369,-0.0418848167539267,-0.440860215053763,0.427564102564103,"Destabilising","Stabilising","Stabilising","Destabilising","Destabilising","neutral",0.842,1.712,"2:1","147/150","D:T:S:M:A:G:K:R:N:Q:H:E:Y",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage3;lineage4","other_mutations_pyrazinamide","ARG",0,"SRR6325444","SRR6325444","lineage4.3;lineage3","us","","pnca_p.gln122arg","A","T","GLN","QA122","pnca_complex.pdb"
|
|
"Q122R","L4","PZA","Q","Q122",122,"R",NA,"Pre-MDR","OM","hydrophilic","hydrophilic","neutral","basic","polar","pos",24.683,-0.114,0.113,-1.69455,-0.152,-0.16,-41,72,1.334,1,1,132,0.586666666666667,"loop",-4.16666666666667,3.49,NA,NA,NA,NA,NA,-24,-1,0,0,-1,0,0,0,0,2,0,-2,0,0,0,0,0,2,0,3,-1,2,0,0,2,-0.0288753799392097,0.0960884353741496,-0.325799815427209,-0.0259164535379369,-0.0418848167539267,-0.440860215053763,0.427564102564103,"Destabilising","Stabilising","Stabilising","Destabilising","Destabilising","neutral",0.842,1.712,"2:1","147/150","D:T:S:M:A:G:K:R:N:Q:H:E:Y",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage4","other_mutations_pyrazinamide","ARG",0,"SRR6325445","SRR6325445","lineage4.3","us","","pnca_p.gln122arg","A","T","GLN","QA122","pnca_complex.pdb"
|
|
"Q122R","L4","PZA","Q","Q122",122,"R",NA,"Pre-MDR","OM","hydrophilic","hydrophilic","neutral","basic","polar","pos",24.683,-0.114,0.113,-1.69455,-0.152,-0.16,-41,72,1.334,1,1,132,0.586666666666667,"loop",-4.16666666666667,3.49,NA,NA,NA,NA,NA,-24,-1,0,0,-1,0,0,0,0,2,0,-2,0,0,0,0,0,2,0,3,-1,2,0,0,2,-0.0288753799392097,0.0960884353741496,-0.325799815427209,-0.0259164535379369,-0.0418848167539267,-0.440860215053763,0.427564102564103,"Destabilising","Stabilising","Stabilising","Destabilising","Destabilising","neutral",0.842,1.712,"2:1","147/150","D:T:S:M:A:G:K:R:N:Q:H:E:Y",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage4","other_mutations_pyrazinamide","ARG",0,"SRR6325448","SRR6325448","lineage4.3","us","","pnca_p.gln122arg","A","T","GLN","QA122","pnca_complex.pdb"
|
|
"Q122R","L4","PZA","Q","Q122",122,"R",NA,"Sensitive","OM","hydrophilic","hydrophilic","neutral","basic","polar","pos",24.683,-0.114,0.113,-1.69455,-0.152,-0.16,-41,72,1.334,1,1,132,0.586666666666667,"loop",-4.16666666666667,3.49,NA,NA,NA,NA,NA,-24,-1,0,0,-1,0,0,0,0,2,0,-2,0,0,0,0,0,2,0,3,-1,2,0,0,2,-0.0288753799392097,0.0960884353741496,-0.325799815427209,-0.0259164535379369,-0.0418848167539267,-0.440860215053763,0.427564102564103,"Destabilising","Stabilising","Stabilising","Destabilising","Destabilising","neutral",0.842,1.712,"2:1","147/150","D:T:S:M:A:G:K:R:N:Q:H:E:Y",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage4","other_mutations_pyrazinamide","ARG",0,"ERR2229708","ERR2229708","lineage4.8","dk","","pnca_p.gln122arg","A","T","GLN","QA122","pnca_complex.pdb"
|
|
"R123G","L1","PZA","R","R123",123,"G",NA,"MDR","OM","hydrophilic","hydrophobic","basic","neutral","pos","non-polar",23.59,-1.129,-1.212,2.77078,-1.005,-0.9,51,75,0.659,3,3,98,0.357664233576642,"loop",-2.8,3.81,NA,NA,NA,NA,NA,50,16,0,2,14,0,0,0,0,2,0,0,2,0,0,0,0,1,0,3,-3,6,0,11,17,-0.28596757852077,-0.313178294573643,0.100917838853721,-0.171355498721228,-0.235602094240838,0.536842105263158,0.211217948717949,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.389,0.842,"4:2","147/150","Q:H:F:Y:E:K:I:C:R:N:V:L:T:A:M",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage1","other_mutations_pyrazinamide","GLY",0,"ERR1213910","ERR1213910","lineage1.2.1","ph","Philippines","pnca_p.arg123gly","A","T","ARG","RA123","pnca_complex.pdb"
|
|
"R123P","L2","PZA","R","R123",123,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","basic","non-polar","pos","non-polar",23.59,-0.955,-0.348,3.53353,-1.065,-0.23,54,75,0.659,3,3,98,0.357664233576642,"loop",-2.8,3.81,0.0001437401178668,19.411022297013,511754.463554485,Inf,4.73122070382274,42,16,0,2,14,0,0,0,0,3,0,1,2,0,0,0,0,4,2,-2,0,6,0,2,4,-0.241894630192503,-0.089922480620155,0.12869885415832,-0.181585677749361,-0.0602094240837696,0.568421052631579,0.211217948717949,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.389,0.842,"4:2","147/150","Q:H:F:Y:E:K:I:C:R:N:V:L:T:A:M",13.1456002256242,0.924803768447114,139.27718332682,0.0943844491367796,0.0001628371344393,NA,1.28804840845689,0.0292235860951597,1.53426649183163,0.91081598550184,Inf,0.0296198560706035,"lineage2","dr_mutations_pyrazinamide","PRO",0,"ERS458430,SAMEA2535028","ERR552955_ERR552956","lineage2.2.1","uz","Nukus","pnca_p.arg123pro","A","T","ARG","RA123","pnca_complex.pdb"
|
|
"R123P","L2","PZA","R","R123",123,"P",NA,"MDR","DM","hydrophilic","hydrophilic","basic","non-polar","pos","non-polar",23.59,-0.955,-0.348,3.53353,-1.065,-0.23,54,75,0.659,3,3,98,0.357664233576642,"loop",-2.8,3.81,0.0001437401178668,19.411022297013,511754.463554485,Inf,4.73122070382274,42,16,0,2,14,0,0,0,0,3,0,1,2,0,0,0,0,4,2,-2,0,6,0,2,4,-0.241894630192503,-0.089922480620155,0.12869885415832,-0.181585677749361,-0.0602094240837696,0.568421052631579,0.211217948717949,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.389,0.842,"4:2","147/150","Q:H:F:Y:E:K:I:C:R:N:V:L:T:A:M",13.1456002256242,0.924803768447114,139.27718332682,0.0943844491367796,0.0001628371344393,NA,1.28804840845689,0.0292235860951597,1.53426649183163,0.91081598550184,Inf,0.0296198560706035,"lineage2","dr_mutations_pyrazinamide","PRO",0,"ERR133936,0785E-sc-2012-02-09T18:57:05Z-1355269","ERR133936","lineage2.2.1","ru","Russia","pnca_p.arg123pro","A","T","ARG","RA123","pnca_complex.pdb"
|
|
"R123P","L4","PZA","R","R123",123,"P",1,"Pre-MDR","DM","hydrophilic","hydrophilic","basic","non-polar","pos","non-polar",23.59,-0.955,-0.348,3.53353,-1.065,-0.23,54,75,0.659,3,3,98,0.357664233576642,"loop",-2.8,3.81,0.0001437401178668,19.411022297013,511754.463554485,Inf,4.73122070382274,42,16,0,2,14,0,0,0,0,3,0,1,2,0,0,0,0,4,2,-2,0,6,0,2,4,-0.241894630192503,-0.089922480620155,0.12869885415832,-0.181585677749361,-0.0602094240837696,0.568421052631579,0.211217948717949,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.389,0.842,"4:2","147/150","Q:H:F:Y:E:K:I:C:R:N:V:L:T:A:M",13.1456002256242,0.924803768447114,139.27718332682,0.0943844491367796,0.0001628371344393,NA,1.28804840845689,0.0292235860951597,1.53426649183163,0.91081598550184,Inf,0.0296198560706035,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR2041711","ERR2041711","lineage4.8","rs","Serbia","pnca_p.arg123pro","A","T","ARG","RA123","pnca_complex.pdb"
|
|
"G124R","L4","PZA","G","G124",124,"R",NA,"Pre-MDR","OM","hydrophobic","hydrophilic","neutral","basic","non-polar","pos",26.025,-0.075,-0.757,-0.489243,-0.439,-0.47,28,63,1.071,1,1,36,0.346153846153846,"loop",-0.233333333333333,3.58,NA,NA,NA,NA,NA,-20,-14,0,-2,-12,0,0,0,0,-2,0,0,-2,0,0,0,0,-2,0,-5,-2,4,0,-1,1,-0.0189969604863221,-0.195607235142119,-0.0940634853495347,-0.0748508098891731,-0.12303664921466,0.294736842105263,0.343269230769231,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",0.59,1.183,"3:1","147/150","A:S:G:D:Q:E:R:K:N",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage4","other_mutations_pyrazinamide","ARG",0,"ERR3148213","ERR3148213","lineage4.3.4.1","mx","Mexico","pnca_p.gly124arg","A","T","GLY","GA124","pnca_complex.pdb"
|
|
"G124S","L1","PZA","G","G124",124,"S",0,"Sensitive","OM","hydrophobic","hydrophilic","neutral","neutral","non-polar","polar",26.025,0.612,-1.24,1.1133,-0.85,-0.39,-22,61,1.071,1,1,36,0.346153846153846,"loop",-0.233333333333333,3.58,7.18700589334483e-05,2.42412778478352,0.0001249735077034,0,1.03410070803344e-29,0,0,0,0,0,0,0,0,0,-2,0,-2,0,0,0,0,0,-1,0,-3,0,0,0,-3,-9,0.274439461883408,-0.320413436692506,0.0405488093590425,-0.144927536231884,-0.102094240837696,-0.236559139784946,0.343269230769231,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","neutral",0.59,1.183,"3:1","147/150","A:S:G:D:Q:E:R:K:N",-8.98740878149641,0.940032862253633,119.46804443549,-0.0752285585987759,NA,4692673.51081215,0.384555509373631,1,0,0,188.544222231268,0.999999999999997,"lineage1","other_mutations_pyrazinamide","SER",0,"ERR2513039","ERR2513039","lineage1.1.2","gb","UK","pnca_p.gly124ser","A","T","GLY","GA124","pnca_complex.pdb"
|
|
"V125A","L1","PZA","V","V125",125,"A",NA,"Sensitive","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",21.367,-1.941,-2.449,2.08114,-2.189,-1.89,49,71,-0.095,5,5,0,0,"loop",0.1,6.12,NA,NA,NA,NA,NA,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-1,2,4,0,4,5,-0.491641337386018,-0.6328165374677,0.0757996488902163,-0.373231031543052,-0.494764397905759,0.515789473684211,-0.0782537067545305,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","147/150","I:L:V:Q:F:A:E",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage1","other_mutations_pyrazinamide","ALA",0,"DRR185019","DRR185019","lineage1.1.1","vn","Vietnam","pnca_p.val125ala","A","-","VAL","VA125","pnca_complex.pdb"
|
|
"V125D","L4","PZA","V","V125",125,"D",NA,"Other","DM","hydrophobic","hydrophilic","non-polar","acidic","non-polar","neg",21.367,-0.358,-3.013,3.9883,-4.507,-2.67,74,85,-0.095,5,5,0,0,"loop",0.1,6.12,0.0002156101768003,0.807902480033628,4.5966027178939e-05,0,0.000393645565148,-8,-32,0,-2,-30,0,0,0,0,-2,0,-2,0,0,0,0,0,-8,0,-6,-1,2,0,2,-2,-0.0906788247213779,-0.778552971576227,0.145262567472082,-0.76845694799659,-0.698952879581152,0.778947368421053,-0.0782537067545305,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","147/150","I:L:V:Q:F:A:E",-9.98760797391818,0.930014323968984,113.719344729606,-0.0878268160765965,NA,127.948735098941,-0.0926410587047397,1,0,0,11.7369754738005,0.984170607395186,"lineage4","dr_mutations_pyrazinamide","ASP",0,"ERR2229701","ERR2229701","lineage4.8","dk","","pnca_p.val125asp","A","-","VAL","VA125","pnca_complex.pdb"
|
|
"V125D","L4","PZA","V","V125",125,"D",NA,"Other","DM","hydrophobic","hydrophilic","non-polar","acidic","non-polar","neg",21.367,-0.358,-3.013,3.9883,-4.507,-2.67,74,85,-0.095,5,5,0,0,"loop",0.1,6.12,0.0002156101768003,0.807902480033628,4.5966027178939e-05,0,0.000393645565148,-8,-32,0,-2,-30,0,0,0,0,-2,0,-2,0,0,0,0,0,-8,0,-6,-1,2,0,2,-2,-0.0906788247213779,-0.778552971576227,0.145262567472082,-0.76845694799659,-0.698952879581152,0.778947368421053,-0.0782537067545305,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","147/150","I:L:V:Q:F:A:E",-9.98760797391818,0.930014323968984,113.719344729606,-0.0878268160765965,NA,127.948735098941,-0.0926410587047397,1,0,0,11.7369754738005,0.984170607395186,"lineage4","dr_mutations_pyrazinamide","ASP",0,"ERR2229152","ERR2229152","lineage4.8","dk","","pnca_p.val125asp","A","-","VAL","VA125","pnca_complex.pdb"
|
|
"V125D","L4","PZA","V","V125",125,"D",NA,"Other","DM","hydrophobic","hydrophilic","non-polar","acidic","non-polar","neg",21.367,-0.358,-3.013,3.9883,-4.507,-2.67,74,85,-0.095,5,5,0,0,"loop",0.1,6.12,0.0002156101768003,0.807902480033628,4.5966027178939e-05,0,0.000393645565148,-8,-32,0,-2,-30,0,0,0,0,-2,0,-2,0,0,0,0,0,-8,0,-6,-1,2,0,2,-2,-0.0906788247213779,-0.778552971576227,0.145262567472082,-0.76845694799659,-0.698952879581152,0.778947368421053,-0.0782537067545305,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","147/150","I:L:V:Q:F:A:E",-9.98760797391818,0.930014323968984,113.719344729606,-0.0878268160765965,NA,127.948735098941,-0.0926410587047397,1,0,0,11.7369754738005,0.984170607395186,"lineage4","dr_mutations_pyrazinamide","ASP",0,"ERR2229698","ERR2229698","lineage4.8","dk","","pnca_p.val125asp","A","-","VAL","VA125","pnca_complex.pdb"
|
|
"V125D","L4","PZA","V","V125",125,"D",NA,"Other","DM","hydrophobic","hydrophilic","non-polar","acidic","non-polar","neg",21.367,-0.358,-3.013,3.9883,-4.507,-2.67,74,85,-0.095,5,5,0,0,"loop",0.1,6.12,0.0002156101768003,0.807902480033628,4.5966027178939e-05,0,0.000393645565148,-8,-32,0,-2,-30,0,0,0,0,-2,0,-2,0,0,0,0,0,-8,0,-6,-1,2,0,2,-2,-0.0906788247213779,-0.778552971576227,0.145262567472082,-0.76845694799659,-0.698952879581152,0.778947368421053,-0.0782537067545305,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","147/150","I:L:V:Q:F:A:E",-9.98760797391818,0.930014323968984,113.719344729606,-0.0878268160765965,NA,127.948735098941,-0.0926410587047397,1,0,0,11.7369754738005,0.984170607395186,"lineage4","dr_mutations_pyrazinamide","ASP",0,"ERR2229752","ERR2229752","lineage4.8","dk","","pnca_p.val125asp","A","-","VAL","VA125","pnca_complex.pdb"
|
|
"V125D","L4","PZA","V","V125",125,"D",NA,"Other","DM","hydrophobic","hydrophilic","non-polar","acidic","non-polar","neg",21.367,-0.358,-3.013,3.9883,-4.507,-2.67,74,85,-0.095,5,5,0,0,"loop",0.1,6.12,0.0002156101768003,0.807902480033628,4.5966027178939e-05,0,0.000393645565148,-8,-32,0,-2,-30,0,0,0,0,-2,0,-2,0,0,0,0,0,-8,0,-6,-1,2,0,2,-2,-0.0906788247213779,-0.778552971576227,0.145262567472082,-0.76845694799659,-0.698952879581152,0.778947368421053,-0.0782537067545305,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","147/150","I:L:V:Q:F:A:E",-9.98760797391818,0.930014323968984,113.719344729606,-0.0878268160765965,NA,127.948735098941,-0.0926410587047397,1,0,0,11.7369754738005,0.984170607395186,"lineage4","dr_mutations_pyrazinamide","ASP",0,"ERR2229199","ERR2229199","lineage4.8","dk","","pnca_p.val125asp","A","-","VAL","VA125","pnca_complex.pdb"
|
|
"V125D","L4","PZA","V","V125",125,"D",NA,"Other","DM","hydrophobic","hydrophilic","non-polar","acidic","non-polar","neg",21.367,-0.358,-3.013,3.9883,-4.507,-2.67,74,85,-0.095,5,5,0,0,"loop",0.1,6.12,0.0002156101768003,0.807902480033628,4.5966027178939e-05,0,0.000393645565148,-8,-32,0,-2,-30,0,0,0,0,-2,0,-2,0,0,0,0,0,-8,0,-6,-1,2,0,2,-2,-0.0906788247213779,-0.778552971576227,0.145262567472082,-0.76845694799659,-0.698952879581152,0.778947368421053,-0.0782537067545305,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","147/150","I:L:V:Q:F:A:E",-9.98760797391818,0.930014323968984,113.719344729606,-0.0878268160765965,NA,127.948735098941,-0.0926410587047397,1,0,0,11.7369754738005,0.984170607395186,"lineage4","dr_mutations_pyrazinamide","ASP",0,"ERR2229052","ERR2229052","lineage4.8","dk","","pnca_p.val125asp","A","-","VAL","VA125","pnca_complex.pdb"
|
|
"V125D","L4","PZA","V","V125",125,"D",NA,"MDR","DM","hydrophobic","hydrophilic","non-polar","acidic","non-polar","neg",21.367,-0.358,-3.013,3.9883,-4.507,-2.67,74,85,-0.095,5,5,0,0,"loop",0.1,6.12,0.0002156101768003,0.807902480033628,4.5966027178939e-05,0,0.000393645565148,-8,-32,0,-2,-30,0,0,0,0,-2,0,-2,0,0,0,0,0,-8,0,-6,-1,2,0,2,-2,-0.0906788247213779,-0.778552971576227,0.145262567472082,-0.76845694799659,-0.698952879581152,0.778947368421053,-0.0782537067545305,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","147/150","I:L:V:Q:F:A:E",-9.98760797391818,0.930014323968984,113.719344729606,-0.0878268160765965,NA,127.948735098941,-0.0926410587047397,1,0,0,11.7369754738005,0.984170607395186,"lineage4","dr_mutations_pyrazinamide","ASP",0,"ERR2229198","ERR2229198","lineage4.8","dk","","pnca_p.val125asp","A","-","VAL","VA125","pnca_complex.pdb"
|
|
"V125D","L4","PZA","V","V125",125,"D",NA,"Other","DM","hydrophobic","hydrophilic","non-polar","acidic","non-polar","neg",21.367,-0.358,-3.013,3.9883,-4.507,-2.67,74,85,-0.095,5,5,0,0,"loop",0.1,6.12,0.0002156101768003,0.807902480033628,4.5966027178939e-05,0,0.000393645565148,-8,-32,0,-2,-30,0,0,0,0,-2,0,-2,0,0,0,0,0,-8,0,-6,-1,2,0,2,-2,-0.0906788247213779,-0.778552971576227,0.145262567472082,-0.76845694799659,-0.698952879581152,0.778947368421053,-0.0782537067545305,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","147/150","I:L:V:Q:F:A:E",-9.98760797391818,0.930014323968984,113.719344729606,-0.0878268160765965,NA,127.948735098941,-0.0926410587047397,1,0,0,11.7369754738005,0.984170607395186,"lineage4","dr_mutations_pyrazinamide","ASP",0,"ERR2229700","ERR2229700","lineage4.8","dk","","pnca_p.val125asp","A","-","VAL","VA125","pnca_complex.pdb"
|
|
"V125D","L4","PZA","V","V125",125,"D",NA,"Other","DM","hydrophobic","hydrophilic","non-polar","acidic","non-polar","neg",21.367,-0.358,-3.013,3.9883,-4.507,-2.67,74,85,-0.095,5,5,0,0,"loop",0.1,6.12,0.0002156101768003,0.807902480033628,4.5966027178939e-05,0,0.000393645565148,-8,-32,0,-2,-30,0,0,0,0,-2,0,-2,0,0,0,0,0,-8,0,-6,-1,2,0,2,-2,-0.0906788247213779,-0.778552971576227,0.145262567472082,-0.76845694799659,-0.698952879581152,0.778947368421053,-0.0782537067545305,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","147/150","I:L:V:Q:F:A:E",-9.98760797391818,0.930014323968984,113.719344729606,-0.0878268160765965,NA,127.948735098941,-0.0926410587047397,1,0,0,11.7369754738005,0.984170607395186,"lineage4","dr_mutations_pyrazinamide","ASP",0,"ERR2229247","ERR2229247","lineage4.8","dk","","pnca_p.val125asp","A","-","VAL","VA125","pnca_complex.pdb"
|
|
"V125D","L4","PZA","V","V125",125,"D",NA,"Other","DM","hydrophobic","hydrophilic","non-polar","acidic","non-polar","neg",21.367,-0.358,-3.013,3.9883,-4.507,-2.67,74,85,-0.095,5,5,0,0,"loop",0.1,6.12,0.0002156101768003,0.807902480033628,4.5966027178939e-05,0,0.000393645565148,-8,-32,0,-2,-30,0,0,0,0,-2,0,-2,0,0,0,0,0,-8,0,-6,-1,2,0,2,-2,-0.0906788247213779,-0.778552971576227,0.145262567472082,-0.76845694799659,-0.698952879581152,0.778947368421053,-0.0782537067545305,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","147/150","I:L:V:Q:F:A:E",-9.98760797391818,0.930014323968984,113.719344729606,-0.0878268160765965,NA,127.948735098941,-0.0926410587047397,1,0,0,11.7369754738005,0.984170607395186,"lineage4","dr_mutations_pyrazinamide","ASP",0,"ERR2229421","ERR2229421","lineage4.8","dk","","pnca_p.val125asp","A","-","VAL","VA125","pnca_complex.pdb"
|
|
"V125D","L4","PZA","V","V125",125,"D",0,"Pre-MDR","DM","hydrophobic","hydrophilic","non-polar","acidic","non-polar","neg",21.367,-0.358,-3.013,3.9883,-4.507,-2.67,74,85,-0.095,5,5,0,0,"loop",0.1,6.12,0.0002156101768003,0.807902480033628,4.5966027178939e-05,0,0.000393645565148,-8,-32,0,-2,-30,0,0,0,0,-2,0,-2,0,0,0,0,0,-8,0,-6,-1,2,0,2,-2,-0.0906788247213779,-0.778552971576227,0.145262567472082,-0.76845694799659,-0.698952879581152,0.778947368421053,-0.0782537067545305,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","147/150","I:L:V:Q:F:A:E",-9.98760797391818,0.930014323968984,113.719344729606,-0.0878268160765965,NA,127.948735098941,-0.0926410587047397,1,0,0,11.7369754738005,0.984170607395186,"lineage4","dr_mutations_pyrazinamide","ASP",0,"ERR2510681","ERR2510681","lineage4.4.1.1","it","Italy","pnca_p.val125asp","A","-","VAL","VA125","pnca_complex.pdb"
|
|
"V125D","L4","PZA","V","V125",125,"D",0,"MDR","DM","hydrophobic","hydrophilic","non-polar","acidic","non-polar","neg",21.367,-0.358,-3.013,3.9883,-4.507,-2.67,74,85,-0.095,5,5,0,0,"loop",0.1,6.12,0.0002156101768003,0.807902480033628,4.5966027178939e-05,0,0.000393645565148,-8,-32,0,-2,-30,0,0,0,0,-2,0,-2,0,0,0,0,0,-8,0,-6,-1,2,0,2,-2,-0.0906788247213779,-0.778552971576227,0.145262567472082,-0.76845694799659,-0.698952879581152,0.778947368421053,-0.0782537067545305,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","147/150","I:L:V:Q:F:A:E",-9.98760797391818,0.930014323968984,113.719344729606,-0.0878268160765965,NA,127.948735098941,-0.0926410587047397,1,0,0,11.7369754738005,0.984170607395186,"lineage4","dr_mutations_pyrazinamide","ASP",0,"SAMN02053762","SRR833150_SRR833035","lineage4.1.1.1","za","South Africa","pnca_p.val125asp","A","-","VAL","VA125","pnca_complex.pdb"
|
|
"V125D","L4","PZA","V","V125",125,"D",NA,"Other","DM","hydrophobic","hydrophilic","non-polar","acidic","non-polar","neg",21.367,-0.358,-3.013,3.9883,-4.507,-2.67,74,85,-0.095,5,5,0,0,"loop",0.1,6.12,0.0002156101768003,0.807902480033628,4.5966027178939e-05,0,0.000393645565148,-8,-32,0,-2,-30,0,0,0,0,-2,0,-2,0,0,0,0,0,-8,0,-6,-1,2,0,2,-2,-0.0906788247213779,-0.778552971576227,0.145262567472082,-0.76845694799659,-0.698952879581152,0.778947368421053,-0.0782537067545305,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","147/150","I:L:V:Q:F:A:E",-9.98760797391818,0.930014323968984,113.719344729606,-0.0878268160765965,NA,127.948735098941,-0.0926410587047397,1,0,0,11.7369754738005,0.984170607395186,"lineage4","dr_mutations_pyrazinamide","ASP",0,"ERR2229124","ERR2229124","lineage4.8","dk","","pnca_p.val125asp","A","-","VAL","VA125","pnca_complex.pdb"
|
|
"V125D","L4","PZA","V","V125",125,"D",NA,"Other","DM","hydrophobic","hydrophilic","non-polar","acidic","non-polar","neg",21.367,-0.358,-3.013,3.9883,-4.507,-2.67,74,85,-0.095,5,5,0,0,"loop",0.1,6.12,0.0002156101768003,0.807902480033628,4.5966027178939e-05,0,0.000393645565148,-8,-32,0,-2,-30,0,0,0,0,-2,0,-2,0,0,0,0,0,-8,0,-6,-1,2,0,2,-2,-0.0906788247213779,-0.778552971576227,0.145262567472082,-0.76845694799659,-0.698952879581152,0.778947368421053,-0.0782537067545305,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","147/150","I:L:V:Q:F:A:E",-9.98760797391818,0.930014323968984,113.719344729606,-0.0878268160765965,NA,127.948735098941,-0.0926410587047397,1,0,0,11.7369754738005,0.984170607395186,"lineage4","dr_mutations_pyrazinamide","ASP",0,"ERR2229686","ERR2229686","lineage4.8","dk","","pnca_p.val125asp","A","-","VAL","VA125","pnca_complex.pdb"
|
|
"V125D","L2","PZA","V","V125",125,"D",0,"Pre-MDR","DM","hydrophobic","hydrophilic","non-polar","acidic","non-polar","neg",21.367,-0.358,-3.013,3.9883,-4.507,-2.67,74,85,-0.095,5,5,0,0,"loop",0.1,6.12,0.0002156101768003,0.807902480033628,4.5966027178939e-05,0,0.000393645565148,-8,-32,0,-2,-30,0,0,0,0,-2,0,-2,0,0,0,0,0,-8,0,-6,-1,2,0,2,-2,-0.0906788247213779,-0.778552971576227,0.145262567472082,-0.76845694799659,-0.698952879581152,0.778947368421053,-0.0782537067545305,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","147/150","I:L:V:Q:F:A:E",-9.98760797391818,0.930014323968984,113.719344729606,-0.0878268160765965,NA,127.948735098941,-0.0926410587047397,1,0,0,11.7369754738005,0.984170607395186,"lineage2","dr_mutations_pyrazinamide","ASP",0,"SRR6369877","SRR6369877","lineage2.2.1","au","Australia","pnca_p.val125asp","A","-","VAL","VA125","pnca_complex.pdb"
|
|
"V125D","L4","PZA","V","V125",125,"D",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","non-polar","acidic","non-polar","neg",21.367,-0.358,-3.013,3.9883,-4.507,-2.67,74,85,-0.095,5,5,0,0,"loop",0.1,6.12,0.0002156101768003,0.807902480033628,4.5966027178939e-05,0,0.000393645565148,-8,-32,0,-2,-30,0,0,0,0,-2,0,-2,0,0,0,0,0,-8,0,-6,-1,2,0,2,-2,-0.0906788247213779,-0.778552971576227,0.145262567472082,-0.76845694799659,-0.698952879581152,0.778947368421053,-0.0782537067545305,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","147/150","I:L:V:Q:F:A:E",-9.98760797391818,0.930014323968984,113.719344729606,-0.0878268160765965,NA,127.948735098941,-0.0926410587047397,1,0,0,11.7369754738005,0.984170607395186,"lineage4","dr_mutations_pyrazinamide","ASP",0,"SAMN02585971","SRR1180201_SRR1181173_SRR1181115_SRR1183131","lineage4.1.1.1","za","South Africa","pnca_p.val125asp","A","-","VAL","VA125","pnca_complex.pdb"
|
|
"V125D","L4","PZA","V","V125",125,"D",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","non-polar","acidic","non-polar","neg",21.367,-0.358,-3.013,3.9883,-4.507,-2.67,74,85,-0.095,5,5,0,0,"loop",0.1,6.12,0.0002156101768003,0.807902480033628,4.5966027178939e-05,0,0.000393645565148,-8,-32,0,-2,-30,0,0,0,0,-2,0,-2,0,0,0,0,0,-8,0,-6,-1,2,0,2,-2,-0.0906788247213779,-0.778552971576227,0.145262567472082,-0.76845694799659,-0.698952879581152,0.778947368421053,-0.0782537067545305,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","147/150","I:L:V:Q:F:A:E",-9.98760797391818,0.930014323968984,113.719344729606,-0.0878268160765965,NA,127.948735098941,-0.0926410587047397,1,0,0,11.7369754738005,0.984170607395186,"lineage4","dr_mutations_pyrazinamide","ASP",0,"SAMN02585974","SRR1180425_SRR1181354_SRR1181326_SRR1180436","lineage4.1.1.1","za","South Africa","pnca_p.val125asp","A","-","VAL","VA125","pnca_complex.pdb"
|
|
"V125D","L4","PZA","V","V125",125,"D",NA,"Other","DM","hydrophobic","hydrophilic","non-polar","acidic","non-polar","neg",21.367,-0.358,-3.013,3.9883,-4.507,-2.67,74,85,-0.095,5,5,0,0,"loop",0.1,6.12,0.0002156101768003,0.807902480033628,4.5966027178939e-05,0,0.000393645565148,-8,-32,0,-2,-30,0,0,0,0,-2,0,-2,0,0,0,0,0,-8,0,-6,-1,2,0,2,-2,-0.0906788247213779,-0.778552971576227,0.145262567472082,-0.76845694799659,-0.698952879581152,0.778947368421053,-0.0782537067545305,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","147/150","I:L:V:Q:F:A:E",-9.98760797391818,0.930014323968984,113.719344729606,-0.0878268160765965,NA,127.948735098941,-0.0926410587047397,1,0,0,11.7369754738005,0.984170607395186,"lineage4","dr_mutations_pyrazinamide","ASP",0,"ERR2229228","ERR2229228","lineage4","dk","","pnca_p.val125asp","A","-","VAL","VA125","pnca_complex.pdb"
|
|
"V125D","L4","PZA","V","V125",125,"D",NA,"Other","DM","hydrophobic","hydrophilic","non-polar","acidic","non-polar","neg",21.367,-0.358,-3.013,3.9883,-4.507,-2.67,74,85,-0.095,5,5,0,0,"loop",0.1,6.12,0.0002156101768003,0.807902480033628,4.5966027178939e-05,0,0.000393645565148,-8,-32,0,-2,-30,0,0,0,0,-2,0,-2,0,0,0,0,0,-8,0,-6,-1,2,0,2,-2,-0.0906788247213779,-0.778552971576227,0.145262567472082,-0.76845694799659,-0.698952879581152,0.778947368421053,-0.0782537067545305,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","147/150","I:L:V:Q:F:A:E",-9.98760797391818,0.930014323968984,113.719344729606,-0.0878268160765965,NA,127.948735098941,-0.0926410587047397,1,0,0,11.7369754738005,0.984170607395186,"lineage4","dr_mutations_pyrazinamide","ASP",0,"ERR2229327","ERR2229327","lineage4.8","dk","","pnca_p.val125asp","A","-","VAL","VA125","pnca_complex.pdb"
|
|
"V125D","L4","PZA","V","V125",125,"D",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","non-polar","acidic","non-polar","neg",21.367,-0.358,-3.013,3.9883,-4.507,-2.67,74,85,-0.095,5,5,0,0,"loop",0.1,6.12,0.0002156101768003,0.807902480033628,4.5966027178939e-05,0,0.000393645565148,-8,-32,0,-2,-30,0,0,0,0,-2,0,-2,0,0,0,0,0,-8,0,-6,-1,2,0,2,-2,-0.0906788247213779,-0.778552971576227,0.145262567472082,-0.76845694799659,-0.698952879581152,0.778947368421053,-0.0782537067545305,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","147/150","I:L:V:Q:F:A:E",-9.98760797391818,0.930014323968984,113.719344729606,-0.0878268160765965,NA,127.948735098941,-0.0926410587047397,1,0,0,11.7369754738005,0.984170607395186,"lineage4","dr_mutations_pyrazinamide","ASP",0,"SAMN02585968","SRR1181142_SRR1184020_SRR1180200_SRR1183146","lineage4.1.1.1","za","South Africa","pnca_p.val125asp","A","-","VAL","VA125","pnca_complex.pdb"
|
|
"V125D","L4","PZA","V","V125",125,"D",NA,"Other","DM","hydrophobic","hydrophilic","non-polar","acidic","non-polar","neg",21.367,-0.358,-3.013,3.9883,-4.507,-2.67,74,85,-0.095,5,5,0,0,"loop",0.1,6.12,0.0002156101768003,0.807902480033628,4.5966027178939e-05,0,0.000393645565148,-8,-32,0,-2,-30,0,0,0,0,-2,0,-2,0,0,0,0,0,-8,0,-6,-1,2,0,2,-2,-0.0906788247213779,-0.778552971576227,0.145262567472082,-0.76845694799659,-0.698952879581152,0.778947368421053,-0.0782537067545305,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","147/150","I:L:V:Q:F:A:E",-9.98760797391818,0.930014323968984,113.719344729606,-0.0878268160765965,NA,127.948735098941,-0.0926410587047397,1,0,0,11.7369754738005,0.984170607395186,"lineage4","dr_mutations_pyrazinamide","ASP",0,"ERR2229538","ERR2229538","lineage4.8","dk","","pnca_p.val125asp","A","-","VAL","VA125","pnca_complex.pdb"
|
|
"V125D","L4","PZA","V","V125",125,"D",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","non-polar","acidic","non-polar","neg",21.367,-0.358,-3.013,3.9883,-4.507,-2.67,74,85,-0.095,5,5,0,0,"loop",0.1,6.12,0.0002156101768003,0.807902480033628,4.5966027178939e-05,0,0.000393645565148,-8,-32,0,-2,-30,0,0,0,0,-2,0,-2,0,0,0,0,0,-8,0,-6,-1,2,0,2,-2,-0.0906788247213779,-0.778552971576227,0.145262567472082,-0.76845694799659,-0.698952879581152,0.778947368421053,-0.0782537067545305,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","147/150","I:L:V:Q:F:A:E",-9.98760797391818,0.930014323968984,113.719344729606,-0.0878268160765965,NA,127.948735098941,-0.0926410587047397,1,0,0,11.7369754738005,0.984170607395186,"lineage4","dr_mutations_pyrazinamide","ASP",0,"SAMN02350487","SRR1140938_SRR1019163","lineage4.1.1.1","za","South Africa","pnca_p.val125asp","A","-","VAL","VA125","pnca_complex.pdb"
|
|
"V125D","L4","PZA","V","V125",125,"D",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","non-polar","acidic","non-polar","neg",21.367,-0.358,-3.013,3.9883,-4.507,-2.67,74,85,-0.095,5,5,0,0,"loop",0.1,6.12,0.0002156101768003,0.807902480033628,4.5966027178939e-05,0,0.000393645565148,-8,-32,0,-2,-30,0,0,0,0,-2,0,-2,0,0,0,0,0,-8,0,-6,-1,2,0,2,-2,-0.0906788247213779,-0.778552971576227,0.145262567472082,-0.76845694799659,-0.698952879581152,0.778947368421053,-0.0782537067545305,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","147/150","I:L:V:Q:F:A:E",-9.98760797391818,0.930014323968984,113.719344729606,-0.0878268160765965,NA,127.948735098941,-0.0926410587047397,1,0,0,11.7369754738005,0.984170607395186,"lineage4","dr_mutations_pyrazinamide","ASP",0,"SAMN02360602","SRR1049043_SRR1049042_SRR1013646_SRR1013647","lineage4.4.2","kr","South Korea","pnca_p.val125asp","A","-","VAL","VA125","pnca_complex.pdb"
|
|
"V125D","L4","PZA","V","V125",125,"D",NA,"Other","DM","hydrophobic","hydrophilic","non-polar","acidic","non-polar","neg",21.367,-0.358,-3.013,3.9883,-4.507,-2.67,74,85,-0.095,5,5,0,0,"loop",0.1,6.12,0.0002156101768003,0.807902480033628,4.5966027178939e-05,0,0.000393645565148,-8,-32,0,-2,-30,0,0,0,0,-2,0,-2,0,0,0,0,0,-8,0,-6,-1,2,0,2,-2,-0.0906788247213779,-0.778552971576227,0.145262567472082,-0.76845694799659,-0.698952879581152,0.778947368421053,-0.0782537067545305,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","147/150","I:L:V:Q:F:A:E",-9.98760797391818,0.930014323968984,113.719344729606,-0.0878268160765965,NA,127.948735098941,-0.0926410587047397,1,0,0,11.7369754738005,0.984170607395186,"lineage4","dr_mutations_pyrazinamide","ASP",0,"ERR2229340","ERR2229340","lineage4.8","dk","","pnca_p.val125asp","A","-","VAL","VA125","pnca_complex.pdb"
|
|
"V125F","L2","PZA","V","V125",125,"F",NA,"MDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",21.367,-1.707,-1.739,4.56,-1.65,-1.72,48,71,-0.095,5,5,0,0,"loop",0.1,6.12,0.0001437401178668,1.2119588062211,4.59700131334263e-05,0,1.01056822389159e-25,-20,-4,0,-2,-2,0,0,0,0,0,0,0,0,0,0,0,0,-11,0,-6,-10,-2,0,-6,-2,-0.432370820668693,-0.449354005167959,0.166085125911465,-0.281329923273657,-0.450261780104712,0.505263157894737,-0.0782537067545305,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","147/150","I:L:V:Q:F:A:E",-9.98752126245059,0.942832958100734,139.277183325398,-0.0717096729269461,NA,144471.706314848,0.0834878586628579,1,0,0,25.8386585962163,0.999999999999746,"lineage2","other_mutations_pyrazinamide","PHE",0,"SRR1710096","SRR1710096","lineage2.2.1","cn","","pnca_p.val125phe","A","-","VAL","VA125","pnca_complex.pdb"
|
|
"V125F","L3","PZA","V","V125",125,"F",NA,"MDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",21.367,-1.707,-1.739,4.56,-1.65,-1.72,48,71,-0.095,5,5,0,0,"loop",0.1,6.12,0.0001437401178668,1.2119588062211,4.59700131334263e-05,0,1.01056822389159e-25,-20,-4,0,-2,-2,0,0,0,0,0,0,0,0,0,0,0,0,-11,0,-6,-10,-2,0,-6,-2,-0.432370820668693,-0.449354005167959,0.166085125911465,-0.281329923273657,-0.450261780104712,0.505263157894737,-0.0782537067545305,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","147/150","I:L:V:Q:F:A:E",-9.98752126245059,0.942832958100734,139.277183325398,-0.0717096729269461,NA,144471.706314848,0.0834878586628579,1,0,0,25.8386585962163,0.999999999999746,"lineage3","other_mutations_pyrazinamide","PHE",0,"SRR5818617","SRR5818617","lineage3.1.1","dj","Djibouti","pnca_p.val125phe","A","-","VAL","VA125","pnca_complex.pdb"
|
|
"V125F","L4","PZA","V","V125",125,"F",NA,"MDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",21.367,-1.707,-1.739,4.56,-1.65,-1.72,48,71,-0.095,5,5,0,0,"loop",0.1,6.12,0.0001437401178668,1.2119588062211,4.59700131334263e-05,0,1.01056822389159e-25,-20,-4,0,-2,-2,0,0,0,0,0,0,0,0,0,0,0,0,-11,0,-6,-10,-2,0,-6,-2,-0.432370820668693,-0.449354005167959,0.166085125911465,-0.281329923273657,-0.450261780104712,0.505263157894737,-0.0782537067545305,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","147/150","I:L:V:Q:F:A:E",-9.98752126245059,0.942832958100734,139.277183325398,-0.0717096729269461,NA,144471.706314848,0.0834878586628579,1,0,0,25.8386585962163,0.999999999999746,"lineage4","other_mutations_pyrazinamide","PHE",0,"ERR779924","ERR779924","lineage4.1.2.1","pe","","pnca_p.val125phe","A","-","VAL","VA125","pnca_complex.pdb"
|
|
"V125F","L3","PZA","V","V125",125,"F",NA,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",21.367,-1.707,-1.739,4.56,-1.65,-1.72,48,71,-0.095,5,5,0,0,"loop",0.1,6.12,0.0001437401178668,1.2119588062211,4.59700131334263e-05,0,1.01056822389159e-25,-20,-4,0,-2,-2,0,0,0,0,0,0,0,0,0,0,0,0,-11,0,-6,-10,-2,0,-6,-2,-0.432370820668693,-0.449354005167959,0.166085125911465,-0.281329923273657,-0.450261780104712,0.505263157894737,-0.0782537067545305,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","147/150","I:L:V:Q:F:A:E",-9.98752126245059,0.942832958100734,139.277183325398,-0.0717096729269461,NA,144471.706314848,0.0834878586628579,1,0,0,25.8386585962163,0.999999999999746,"lineage3","other_mutations_pyrazinamide","PHE",0,"ERR2513160","ERR2513160","lineage3","gb","UK","pnca_p.val125phe","A","-","VAL","VA125","pnca_complex.pdb"
|
|
"V125F","L3","PZA","V","V125",125,"F",0,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",21.367,-1.707,-1.739,4.56,-1.65,-1.72,48,71,-0.095,5,5,0,0,"loop",0.1,6.12,0.0001437401178668,1.2119588062211,4.59700131334263e-05,0,1.01056822389159e-25,-20,-4,0,-2,-2,0,0,0,0,0,0,0,0,0,0,0,0,-11,0,-6,-10,-2,0,-6,-2,-0.432370820668693,-0.449354005167959,0.166085125911465,-0.281329923273657,-0.450261780104712,0.505263157894737,-0.0782537067545305,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","147/150","I:L:V:Q:F:A:E",-9.98752126245059,0.942832958100734,139.277183325398,-0.0717096729269461,NA,144471.706314848,0.0834878586628579,1,0,0,25.8386585962163,0.999999999999746,"lineage3","other_mutations_pyrazinamide","PHE",0,"ERR2516549","ERR2516549","lineage3","nl","Netherlands","pnca_p.val125phe","A","-","VAL","VA125","pnca_complex.pdb"
|
|
"V125F","L2","PZA","V","V125",125,"F",NA,"Sensitive","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",21.367,-1.707,-1.739,4.56,-1.65,-1.72,48,71,-0.095,5,5,0,0,"loop",0.1,6.12,0.0001437401178668,1.2119588062211,4.59700131334263e-05,0,1.01056822389159e-25,-20,-4,0,-2,-2,0,0,0,0,0,0,0,0,0,0,0,0,-11,0,-6,-10,-2,0,-6,-2,-0.432370820668693,-0.449354005167959,0.166085125911465,-0.281329923273657,-0.450261780104712,0.505263157894737,-0.0782537067545305,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","147/150","I:L:V:Q:F:A:E",-9.98752126245059,0.942832958100734,139.277183325398,-0.0717096729269461,NA,144471.706314848,0.0834878586628579,1,0,0,25.8386585962163,0.999999999999746,"lineage2","other_mutations_pyrazinamide","PHE",0,"SRR5065580","SRR5065580","lineage2.2.2","vn","Vietnam","pnca_p.val125phe","A","-","VAL","VA125","pnca_complex.pdb"
|
|
"V125F","L3","PZA","V","V125",125,"F",0,"MDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",21.367,-1.707,-1.739,4.56,-1.65,-1.72,48,71,-0.095,5,5,0,0,"loop",0.1,6.12,0.0001437401178668,1.2119588062211,4.59700131334263e-05,0,1.01056822389159e-25,-20,-4,0,-2,-2,0,0,0,0,0,0,0,0,0,0,0,0,-11,0,-6,-10,-2,0,-6,-2,-0.432370820668693,-0.449354005167959,0.166085125911465,-0.281329923273657,-0.450261780104712,0.505263157894737,-0.0782537067545305,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","147/150","I:L:V:Q:F:A:E",-9.98752126245059,0.942832958100734,139.277183325398,-0.0717096729269461,NA,144471.706314848,0.0834878586628579,1,0,0,25.8386585962163,0.999999999999746,"lineage3","other_mutations_pyrazinamide","PHE",0,"SAMN07658692","SRR6046512","lineage3","gb","UK","pnca_p.val125phe","A","-","VAL","VA125","pnca_complex.pdb"
|
|
"V125F","L3","PZA","V","V125",125,"F",NA,"MDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",21.367,-1.707,-1.739,4.56,-1.65,-1.72,48,71,-0.095,5,5,0,0,"loop",0.1,6.12,0.0001437401178668,1.2119588062211,4.59700131334263e-05,0,1.01056822389159e-25,-20,-4,0,-2,-2,0,0,0,0,0,0,0,0,0,0,0,0,-11,0,-6,-10,-2,0,-6,-2,-0.432370820668693,-0.449354005167959,0.166085125911465,-0.281329923273657,-0.450261780104712,0.505263157894737,-0.0782537067545305,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","147/150","I:L:V:Q:F:A:E",-9.98752126245059,0.942832958100734,139.277183325398,-0.0717096729269461,NA,144471.706314848,0.0834878586628579,1,0,0,25.8386585962163,0.999999999999746,"lineage3","other_mutations_pyrazinamide","PHE",0,"SRR5818636","SRR5818636","lineage3.1.1","dj","Djibouti","pnca_p.val125phe","A","-","VAL","VA125","pnca_complex.pdb"
|
|
"V125F","L2","PZA","V","V125",125,"F",NA,"Sensitive","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",21.367,-1.707,-1.739,4.56,-1.65,-1.72,48,71,-0.095,5,5,0,0,"loop",0.1,6.12,0.0001437401178668,1.2119588062211,4.59700131334263e-05,0,1.01056822389159e-25,-20,-4,0,-2,-2,0,0,0,0,0,0,0,0,0,0,0,0,-11,0,-6,-10,-2,0,-6,-2,-0.432370820668693,-0.449354005167959,0.166085125911465,-0.281329923273657,-0.450261780104712,0.505263157894737,-0.0782537067545305,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","147/150","I:L:V:Q:F:A:E",-9.98752126245059,0.942832958100734,139.277183325398,-0.0717096729269461,NA,144471.706314848,0.0834878586628579,1,0,0,25.8386585962163,0.999999999999746,"lineage2","other_mutations_pyrazinamide","PHE",0,"SRR5067716","SRR5067716","lineage2.2.2","vn","Vietnam","pnca_p.val125phe","A","-","VAL","VA125","pnca_complex.pdb"
|
|
"V125F","L4","PZA","V","V125",125,"F",NA,"MDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",21.367,-1.707,-1.739,4.56,-1.65,-1.72,48,71,-0.095,5,5,0,0,"loop",0.1,6.12,0.0001437401178668,1.2119588062211,4.59700131334263e-05,0,1.01056822389159e-25,-20,-4,0,-2,-2,0,0,0,0,0,0,0,0,0,0,0,0,-11,0,-6,-10,-2,0,-6,-2,-0.432370820668693,-0.449354005167959,0.166085125911465,-0.281329923273657,-0.450261780104712,0.505263157894737,-0.0782537067545305,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","147/150","I:L:V:Q:F:A:E",-9.98752126245059,0.942832958100734,139.277183325398,-0.0717096729269461,NA,144471.706314848,0.0834878586628579,1,0,0,25.8386585962163,0.999999999999746,"lineage4","other_mutations_pyrazinamide","PHE",0,"ERR779920","ERR779920","lineage4.1.2.1","pe","","pnca_p.val125phe","A","-","VAL","VA125","pnca_complex.pdb"
|
|
"V125F","L4","PZA","V","V125",125,"F",NA,"MDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",21.367,-1.707,-1.739,4.56,-1.65,-1.72,48,71,-0.095,5,5,0,0,"loop",0.1,6.12,0.0001437401178668,1.2119588062211,4.59700131334263e-05,0,1.01056822389159e-25,-20,-4,0,-2,-2,0,0,0,0,0,0,0,0,0,0,0,0,-11,0,-6,-10,-2,0,-6,-2,-0.432370820668693,-0.449354005167959,0.166085125911465,-0.281329923273657,-0.450261780104712,0.505263157894737,-0.0782537067545305,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","147/150","I:L:V:Q:F:A:E",-9.98752126245059,0.942832958100734,139.277183325398,-0.0717096729269461,NA,144471.706314848,0.0834878586628579,1,0,0,25.8386585962163,0.999999999999746,"lineage4","other_mutations_pyrazinamide","PHE",0,"ERR751577","ERR751577","lineage4.1.2.1","pe","","pnca_p.val125phe","A","-","VAL","VA125","pnca_complex.pdb"
|
|
"V125F","L4","PZA","V","V125",125,"F",NA,"MDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",21.367,-1.707,-1.739,4.56,-1.65,-1.72,48,71,-0.095,5,5,0,0,"loop",0.1,6.12,0.0001437401178668,1.2119588062211,4.59700131334263e-05,0,1.01056822389159e-25,-20,-4,0,-2,-2,0,0,0,0,0,0,0,0,0,0,0,0,-11,0,-6,-10,-2,0,-6,-2,-0.432370820668693,-0.449354005167959,0.166085125911465,-0.281329923273657,-0.450261780104712,0.505263157894737,-0.0782537067545305,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","147/150","I:L:V:Q:F:A:E",-9.98752126245059,0.942832958100734,139.277183325398,-0.0717096729269461,NA,144471.706314848,0.0834878586628579,1,0,0,25.8386585962163,0.999999999999746,"lineage4","other_mutations_pyrazinamide","PHE",0,"ERR751632","ERR751632","lineage4.1.2.1","pe","","pnca_p.val125phe","A","-","VAL","VA125","pnca_complex.pdb"
|
|
"V125G","L4","PZA","V","V125",125,"G",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",21.367,-1.814,-3.005,3.83404,-3.24,-2.63,70,85,-0.095,5,5,0,0,"loop",0.1,6.12,0.0031622825930717,67.409751924722,67.4093600119011,67.3855171102593,174.918303180059,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-2,0,-1,0,8,0,13,21,-0.459473150962513,-0.776485788113695,0.139644082488946,-0.552429667519182,-0.68848167539267,0.736842105263158,-0.0782537067545305,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","147/150","I:L:V:Q:F:A:E",4.21078388085649,1.83664466117051e-12,0.597583217500306,7.04635564979589,24.5112444006964,278.636893097378,1.82872272889042,2.05851007546474e-28,27.6864470029886,21.4729050424094,338.090551978209,6.23802610818127e-40,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR275229","ERR275229","lineage4.3.4.2","pt","Portugal","pnca_p.val125gly","A","-","VAL","VA125","pnca_complex.pdb"
|
|
"V125G","L4","PZA","V","V125",125,"G",1,"XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",21.367,-1.814,-3.005,3.83404,-3.24,-2.63,70,85,-0.095,5,5,0,0,"loop",0.1,6.12,0.0031622825930717,67.409751924722,67.4093600119011,67.3855171102593,174.918303180059,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-2,0,-1,0,8,0,13,21,-0.459473150962513,-0.776485788113695,0.139644082488946,-0.552429667519182,-0.68848167539267,0.736842105263158,-0.0782537067545305,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","147/150","I:L:V:Q:F:A:E",4.21078388085649,1.83664466117051e-12,0.597583217500306,7.04635564979589,24.5112444006964,278.636893097378,1.82872272889042,2.05851007546474e-28,27.6864470029886,21.4729050424094,338.090551978209,6.23802610818127e-40,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR1034821","ERR1034821","lineage4.3.4.2","pt","Portugal","pnca_p.val125gly","A","-","VAL","VA125","pnca_complex.pdb"
|
|
"V125G","L4","PZA","V","V125",125,"G",1,"XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",21.367,-1.814,-3.005,3.83404,-3.24,-2.63,70,85,-0.095,5,5,0,0,"loop",0.1,6.12,0.0031622825930717,67.409751924722,67.4093600119011,67.3855171102593,174.918303180059,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-2,0,-1,0,8,0,13,21,-0.459473150962513,-0.776485788113695,0.139644082488946,-0.552429667519182,-0.68848167539267,0.736842105263158,-0.0782537067545305,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","147/150","I:L:V:Q:F:A:E",4.21078388085649,1.83664466117051e-12,0.597583217500306,7.04635564979589,24.5112444006964,278.636893097378,1.82872272889042,2.05851007546474e-28,27.6864470029886,21.4729050424094,338.090551978209,6.23802610818127e-40,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR2864284","ERR2864284","lineage4.3.4.2","pt","Portugal","pnca_p.val125gly","A","-","VAL","VA125","pnca_complex.pdb"
|
|
"V125G","L4","PZA","V","V125",125,"G",1,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",21.367,-1.814,-3.005,3.83404,-3.24,-2.63,70,85,-0.095,5,5,0,0,"loop",0.1,6.12,0.0031622825930717,67.409751924722,67.4093600119011,67.3855171102593,174.918303180059,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-2,0,-1,0,8,0,13,21,-0.459473150962513,-0.776485788113695,0.139644082488946,-0.552429667519182,-0.68848167539267,0.736842105263158,-0.0782537067545305,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","147/150","I:L:V:Q:F:A:E",4.21078388085649,1.83664466117051e-12,0.597583217500306,7.04635564979589,24.5112444006964,278.636893097378,1.82872272889042,2.05851007546474e-28,27.6864470029886,21.4729050424094,338.090551978209,6.23802610818127e-40,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR1035243","ERR1035243","lineage4.3.4.2","pt","Portugal","pnca_p.val125gly","A","-","VAL","VA125","pnca_complex.pdb"
|
|
"V125G","L4","PZA","V","V125",125,"G",1,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",21.367,-1.814,-3.005,3.83404,-3.24,-2.63,70,85,-0.095,5,5,0,0,"loop",0.1,6.12,0.0031622825930717,67.409751924722,67.4093600119011,67.3855171102593,174.918303180059,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-2,0,-1,0,8,0,13,21,-0.459473150962513,-0.776485788113695,0.139644082488946,-0.552429667519182,-0.68848167539267,0.736842105263158,-0.0782537067545305,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","147/150","I:L:V:Q:F:A:E",4.21078388085649,1.83664466117051e-12,0.597583217500306,7.04635564979589,24.5112444006964,278.636893097378,1.82872272889042,2.05851007546474e-28,27.6864470029886,21.4729050424094,338.090551978209,6.23802610818127e-40,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR1035247","ERR1035247","lineage4.3.4.2","pt","Portugal","pnca_p.val125gly","A","-","VAL","VA125","pnca_complex.pdb"
|
|
"V125G","L2","PZA","V","V125",125,"G",1,"XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",21.367,-1.814,-3.005,3.83404,-3.24,-2.63,70,85,-0.095,5,5,0,0,"loop",0.1,6.12,0.0031622825930717,67.409751924722,67.4093600119011,67.3855171102593,174.918303180059,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-2,0,-1,0,8,0,13,21,-0.459473150962513,-0.776485788113695,0.139644082488946,-0.552429667519182,-0.68848167539267,0.736842105263158,-0.0782537067545305,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","147/150","I:L:V:Q:F:A:E",4.21078388085649,1.83664466117051e-12,0.597583217500306,7.04635564979589,24.5112444006964,278.636893097378,1.82872272889042,2.05851007546474e-28,27.6864470029886,21.4729050424094,338.090551978209,6.23802610818127e-40,"lineage2","dr_mutations_pyrazinamide","GLY",0,"ERS457650","ERR551862_ERR551861","lineage2.2.1","uz","Nukus","pnca_p.val125gly","A","-","VAL","VA125","pnca_complex.pdb"
|
|
"V125G","L4","PZA","V","V125",125,"G",1,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",21.367,-1.814,-3.005,3.83404,-3.24,-2.63,70,85,-0.095,5,5,0,0,"loop",0.1,6.12,0.0031622825930717,67.409751924722,67.4093600119011,67.3855171102593,174.918303180059,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-2,0,-1,0,8,0,13,21,-0.459473150962513,-0.776485788113695,0.139644082488946,-0.552429667519182,-0.68848167539267,0.736842105263158,-0.0782537067545305,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","147/150","I:L:V:Q:F:A:E",4.21078388085649,1.83664466117051e-12,0.597583217500306,7.04635564979589,24.5112444006964,278.636893097378,1.82872272889042,2.05851007546474e-28,27.6864470029886,21.4729050424094,338.090551978209,6.23802610818127e-40,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR2516840","ERR2516840","lineage4.3.4.2","gb","UK","pnca_p.val125gly","A","-","VAL","VA125","pnca_complex.pdb"
|
|
"V125G","L2","PZA","V","V125",125,"G",1,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",21.367,-1.814,-3.005,3.83404,-3.24,-2.63,70,85,-0.095,5,5,0,0,"loop",0.1,6.12,0.0031622825930717,67.409751924722,67.4093600119011,67.3855171102593,174.918303180059,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-2,0,-1,0,8,0,13,21,-0.459473150962513,-0.776485788113695,0.139644082488946,-0.552429667519182,-0.68848167539267,0.736842105263158,-0.0782537067545305,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","147/150","I:L:V:Q:F:A:E",4.21078388085649,1.83664466117051e-12,0.597583217500306,7.04635564979589,24.5112444006964,278.636893097378,1.82872272889042,2.05851007546474e-28,27.6864470029886,21.4729050424094,338.090551978209,6.23802610818127e-40,"lineage2","dr_mutations_pyrazinamide","GLY",0,"ERS457251","ERR551305_ERR551306_ERR551307_ERR551308_ERR551304","lineage2.2.1","uz","Nukus","pnca_p.val125gly","A","-","VAL","VA125","pnca_complex.pdb"
|
|
"V125G","L4","PZA","V","V125",125,"G",1,"XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",21.367,-1.814,-3.005,3.83404,-3.24,-2.63,70,85,-0.095,5,5,0,0,"loop",0.1,6.12,0.0031622825930717,67.409751924722,67.4093600119011,67.3855171102593,174.918303180059,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-2,0,-1,0,8,0,13,21,-0.459473150962513,-0.776485788113695,0.139644082488946,-0.552429667519182,-0.68848167539267,0.736842105263158,-0.0782537067545305,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","147/150","I:L:V:Q:F:A:E",4.21078388085649,1.83664466117051e-12,0.597583217500306,7.04635564979589,24.5112444006964,278.636893097378,1.82872272889042,2.05851007546474e-28,27.6864470029886,21.4729050424094,338.090551978209,6.23802610818127e-40,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR1035221","ERR1035221","lineage4.3.4.2","pt","Portugal","pnca_p.val125gly","A","-","VAL","VA125","pnca_complex.pdb"
|
|
"V125G","L4","PZA","V","V125",125,"G",1,"XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",21.367,-1.814,-3.005,3.83404,-3.24,-2.63,70,85,-0.095,5,5,0,0,"loop",0.1,6.12,0.0031622825930717,67.409751924722,67.4093600119011,67.3855171102593,174.918303180059,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-2,0,-1,0,8,0,13,21,-0.459473150962513,-0.776485788113695,0.139644082488946,-0.552429667519182,-0.68848167539267,0.736842105263158,-0.0782537067545305,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","147/150","I:L:V:Q:F:A:E",4.21078388085649,1.83664466117051e-12,0.597583217500306,7.04635564979589,24.5112444006964,278.636893097378,1.82872272889042,2.05851007546474e-28,27.6864470029886,21.4729050424094,338.090551978209,6.23802610818127e-40,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR1036291","ERR1036291","lineage4.3.4.2","pt","Portugal","pnca_p.val125gly","A","-","VAL","VA125","pnca_complex.pdb"
|
|
"V125G","L2","PZA","V","V125",125,"G",1,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",21.367,-1.814,-3.005,3.83404,-3.24,-2.63,70,85,-0.095,5,5,0,0,"loop",0.1,6.12,0.0031622825930717,67.409751924722,67.4093600119011,67.3855171102593,174.918303180059,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-2,0,-1,0,8,0,13,21,-0.459473150962513,-0.776485788113695,0.139644082488946,-0.552429667519182,-0.68848167539267,0.736842105263158,-0.0782537067545305,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","147/150","I:L:V:Q:F:A:E",4.21078388085649,1.83664466117051e-12,0.597583217500306,7.04635564979589,24.5112444006964,278.636893097378,1.82872272889042,2.05851007546474e-28,27.6864470029886,21.4729050424094,338.090551978209,6.23802610818127e-40,"lineage2","dr_mutations_pyrazinamide","GLY",0,"ERS457818","ERR552106_ERR552105","lineage2.2.1","uz","Nukus","pnca_p.val125gly","A","-","VAL","VA125","pnca_complex.pdb"
|
|
"V125G","L4","PZA","V","V125",125,"G",1,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",21.367,-1.814,-3.005,3.83404,-3.24,-2.63,70,85,-0.095,5,5,0,0,"loop",0.1,6.12,0.0031622825930717,67.409751924722,67.4093600119011,67.3855171102593,174.918303180059,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-2,0,-1,0,8,0,13,21,-0.459473150962513,-0.776485788113695,0.139644082488946,-0.552429667519182,-0.68848167539267,0.736842105263158,-0.0782537067545305,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","147/150","I:L:V:Q:F:A:E",4.21078388085649,1.83664466117051e-12,0.597583217500306,7.04635564979589,24.5112444006964,278.636893097378,1.82872272889042,2.05851007546474e-28,27.6864470029886,21.4729050424094,338.090551978209,6.23802610818127e-40,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR1035181","ERR1035181","lineage4.3.4.2","pt","Portugal","pnca_p.val125gly","A","-","VAL","VA125","pnca_complex.pdb"
|
|
"V125G","L4","PZA","V","V125",125,"G",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",21.367,-1.814,-3.005,3.83404,-3.24,-2.63,70,85,-0.095,5,5,0,0,"loop",0.1,6.12,0.0031622825930717,67.409751924722,67.4093600119011,67.3855171102593,174.918303180059,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-2,0,-1,0,8,0,13,21,-0.459473150962513,-0.776485788113695,0.139644082488946,-0.552429667519182,-0.68848167539267,0.736842105263158,-0.0782537067545305,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","147/150","I:L:V:Q:F:A:E",4.21078388085649,1.83664466117051e-12,0.597583217500306,7.04635564979589,24.5112444006964,278.636893097378,1.82872272889042,2.05851007546474e-28,27.6864470029886,21.4729050424094,338.090551978209,6.23802610818127e-40,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR275221","ERR275221","lineage4.3.4.2","pt","Portugal","pnca_p.val125gly","A","-","VAL","VA125","pnca_complex.pdb"
|
|
"V125G","L4","PZA","V","V125",125,"G",NA,"XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",21.367,-1.814,-3.005,3.83404,-3.24,-2.63,70,85,-0.095,5,5,0,0,"loop",0.1,6.12,0.0031622825930717,67.409751924722,67.4093600119011,67.3855171102593,174.918303180059,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-2,0,-1,0,8,0,13,21,-0.459473150962513,-0.776485788113695,0.139644082488946,-0.552429667519182,-0.68848167539267,0.736842105263158,-0.0782537067545305,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","147/150","I:L:V:Q:F:A:E",4.21078388085649,1.83664466117051e-12,0.597583217500306,7.04635564979589,24.5112444006964,278.636893097378,1.82872272889042,2.05851007546474e-28,27.6864470029886,21.4729050424094,338.090551978209,6.23802610818127e-40,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR275219","ERR275219","lineage4.3.4.2","pt","Portugal","pnca_p.val125gly","A","-","VAL","VA125","pnca_complex.pdb"
|
|
"V125G","L2","PZA","V","V125",125,"G",0,"Other","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",21.367,-1.814,-3.005,3.83404,-3.24,-2.63,70,85,-0.095,5,5,0,0,"loop",0.1,6.12,0.0031622825930717,67.409751924722,67.4093600119011,67.3855171102593,174.918303180059,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-2,0,-1,0,8,0,13,21,-0.459473150962513,-0.776485788113695,0.139644082488946,-0.552429667519182,-0.68848167539267,0.736842105263158,-0.0782537067545305,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","147/150","I:L:V:Q:F:A:E",4.21078388085649,1.83664466117051e-12,0.597583217500306,7.04635564979589,24.5112444006964,278.636893097378,1.82872272889042,2.05851007546474e-28,27.6864470029886,21.4729050424094,338.090551978209,6.23802610818127e-40,"lineage2","dr_mutations_pyrazinamide","GLY",0,"MDR_8128","SRR6824698","lineage2.2.1","cn","China: Hulin City, Jixi City, Heilongjiang Province","pnca_p.val125gly","A","-","VAL","VA125","pnca_complex.pdb"
|
|
"V125G","L4","PZA","V","V125",125,"G",NA,"XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",21.367,-1.814,-3.005,3.83404,-3.24,-2.63,70,85,-0.095,5,5,0,0,"loop",0.1,6.12,0.0031622825930717,67.409751924722,67.4093600119011,67.3855171102593,174.918303180059,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-2,0,-1,0,8,0,13,21,-0.459473150962513,-0.776485788113695,0.139644082488946,-0.552429667519182,-0.68848167539267,0.736842105263158,-0.0782537067545305,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","147/150","I:L:V:Q:F:A:E",4.21078388085649,1.83664466117051e-12,0.597583217500306,7.04635564979589,24.5112444006964,278.636893097378,1.82872272889042,2.05851007546474e-28,27.6864470029886,21.4729050424094,338.090551978209,6.23802610818127e-40,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR1034909","ERR1034909","lineage4.3.4.2","pt","Portugal","pnca_p.val125gly","A","-","VAL","VA125","pnca_complex.pdb"
|
|
"V125G","L4","PZA","V","V125",125,"G",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",21.367,-1.814,-3.005,3.83404,-3.24,-2.63,70,85,-0.095,5,5,0,0,"loop",0.1,6.12,0.0031622825930717,67.409751924722,67.4093600119011,67.3855171102593,174.918303180059,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-2,0,-1,0,8,0,13,21,-0.459473150962513,-0.776485788113695,0.139644082488946,-0.552429667519182,-0.68848167539267,0.736842105263158,-0.0782537067545305,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","147/150","I:L:V:Q:F:A:E",4.21078388085649,1.83664466117051e-12,0.597583217500306,7.04635564979589,24.5112444006964,278.636893097378,1.82872272889042,2.05851007546474e-28,27.6864470029886,21.4729050424094,338.090551978209,6.23802610818127e-40,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR1036293","ERR1036293","lineage4.3.4.2","pt","Portugal","pnca_p.val125gly","A","-","VAL","VA125","pnca_complex.pdb"
|
|
"V125G","L4","PZA","V","V125",125,"G",1,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",21.367,-1.814,-3.005,3.83404,-3.24,-2.63,70,85,-0.095,5,5,0,0,"loop",0.1,6.12,0.0031622825930717,67.409751924722,67.4093600119011,67.3855171102593,174.918303180059,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-2,0,-1,0,8,0,13,21,-0.459473150962513,-0.776485788113695,0.139644082488946,-0.552429667519182,-0.68848167539267,0.736842105263158,-0.0782537067545305,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","147/150","I:L:V:Q:F:A:E",4.21078388085649,1.83664466117051e-12,0.597583217500306,7.04635564979589,24.5112444006964,278.636893097378,1.82872272889042,2.05851007546474e-28,27.6864470029886,21.4729050424094,338.090551978209,6.23802610818127e-40,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR2864250","ERR2864250","lineage4.3.4.2","pt","Portugal","pnca_p.val125gly","A","-","VAL","VA125","pnca_complex.pdb"
|
|
"V125G","L4","PZA","V","V125",125,"G",1,"Pre-MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",21.367,-1.814,-3.005,3.83404,-3.24,-2.63,70,85,-0.095,5,5,0,0,"loop",0.1,6.12,0.0031622825930717,67.409751924722,67.4093600119011,67.3855171102593,174.918303180059,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-2,0,-1,0,8,0,13,21,-0.459473150962513,-0.776485788113695,0.139644082488946,-0.552429667519182,-0.68848167539267,0.736842105263158,-0.0782537067545305,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","147/150","I:L:V:Q:F:A:E",4.21078388085649,1.83664466117051e-12,0.597583217500306,7.04635564979589,24.5112444006964,278.636893097378,1.82872272889042,2.05851007546474e-28,27.6864470029886,21.4729050424094,338.090551978209,6.23802610818127e-40,"lineage4","dr_mutations_pyrazinamide","GLY",0,"SAMN03648508,SRR2101261","SRR2101261","lineage4.1.1.3","","","pnca_p.val125gly","A","-","VAL","VA125","pnca_complex.pdb"
|
|
"V125G","L4","PZA","V","V125",125,"G",NA,"XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",21.367,-1.814,-3.005,3.83404,-3.24,-2.63,70,85,-0.095,5,5,0,0,"loop",0.1,6.12,0.0031622825930717,67.409751924722,67.4093600119011,67.3855171102593,174.918303180059,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-2,0,-1,0,8,0,13,21,-0.459473150962513,-0.776485788113695,0.139644082488946,-0.552429667519182,-0.68848167539267,0.736842105263158,-0.0782537067545305,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","147/150","I:L:V:Q:F:A:E",4.21078388085649,1.83664466117051e-12,0.597583217500306,7.04635564979589,24.5112444006964,278.636893097378,1.82872272889042,2.05851007546474e-28,27.6864470029886,21.4729050424094,338.090551978209,6.23802610818127e-40,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR1034855","ERR1034855","lineage4.3.4.2","pt","Portugal","pnca_p.val125gly","A","-","VAL","VA125","pnca_complex.pdb"
|
|
"V125G","L4","PZA","V","V125",125,"G",1,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",21.367,-1.814,-3.005,3.83404,-3.24,-2.63,70,85,-0.095,5,5,0,0,"loop",0.1,6.12,0.0031622825930717,67.409751924722,67.4093600119011,67.3855171102593,174.918303180059,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-2,0,-1,0,8,0,13,21,-0.459473150962513,-0.776485788113695,0.139644082488946,-0.552429667519182,-0.68848167539267,0.736842105263158,-0.0782537067545305,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","147/150","I:L:V:Q:F:A:E",4.21078388085649,1.83664466117051e-12,0.597583217500306,7.04635564979589,24.5112444006964,278.636893097378,1.82872272889042,2.05851007546474e-28,27.6864470029886,21.4729050424094,338.090551978209,6.23802610818127e-40,"lineage4","dr_mutations_pyrazinamide","GLY",0,"SAMEA2297124,ERS389511,ERR400553","ERR400553","lineage4.3.4.2","gb","United Kingdom","pnca_p.val125gly","A","-","VAL","VA125","pnca_complex.pdb"
|
|
"V125G","L4","PZA","V","V125",125,"G",1,"XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",21.367,-1.814,-3.005,3.83404,-3.24,-2.63,70,85,-0.095,5,5,0,0,"loop",0.1,6.12,0.0031622825930717,67.409751924722,67.4093600119011,67.3855171102593,174.918303180059,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-2,0,-1,0,8,0,13,21,-0.459473150962513,-0.776485788113695,0.139644082488946,-0.552429667519182,-0.68848167539267,0.736842105263158,-0.0782537067545305,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","147/150","I:L:V:Q:F:A:E",4.21078388085649,1.83664466117051e-12,0.597583217500306,7.04635564979589,24.5112444006964,278.636893097378,1.82872272889042,2.05851007546474e-28,27.6864470029886,21.4729050424094,338.090551978209,6.23802610818127e-40,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR1035176","ERR1035176","lineage4.3.4.2","pt","Portugal","pnca_p.val125gly","A","-","VAL","VA125","pnca_complex.pdb"
|
|
"V125G","L4","PZA","V","V125",125,"G",1,"Pre-MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",21.367,-1.814,-3.005,3.83404,-3.24,-2.63,70,85,-0.095,5,5,0,0,"loop",0.1,6.12,0.0031622825930717,67.409751924722,67.4093600119011,67.3855171102593,174.918303180059,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-2,0,-1,0,8,0,13,21,-0.459473150962513,-0.776485788113695,0.139644082488946,-0.552429667519182,-0.68848167539267,0.736842105263158,-0.0782537067545305,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","147/150","I:L:V:Q:F:A:E",4.21078388085649,1.83664466117051e-12,0.597583217500306,7.04635564979589,24.5112444006964,278.636893097378,1.82872272889042,2.05851007546474e-28,27.6864470029886,21.4729050424094,338.090551978209,6.23802610818127e-40,"lineage4","dr_mutations_pyrazinamide","GLY",0,"SRR2100923,SAMN03648170","SRR2100923","lineage4.1.1.3","","","pnca_p.val125gly","A","-","VAL","VA125","pnca_complex.pdb"
|
|
"V125G","L4","PZA","V","V125",125,"G",1,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",21.367,-1.814,-3.005,3.83404,-3.24,-2.63,70,85,-0.095,5,5,0,0,"loop",0.1,6.12,0.0031622825930717,67.409751924722,67.4093600119011,67.3855171102593,174.918303180059,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-2,0,-1,0,8,0,13,21,-0.459473150962513,-0.776485788113695,0.139644082488946,-0.552429667519182,-0.68848167539267,0.736842105263158,-0.0782537067545305,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","147/150","I:L:V:Q:F:A:E",4.21078388085649,1.83664466117051e-12,0.597583217500306,7.04635564979589,24.5112444006964,278.636893097378,1.82872272889042,2.05851007546474e-28,27.6864470029886,21.4729050424094,338.090551978209,6.23802610818127e-40,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR2864218","ERR2864218","lineage4.3.4.2","pt","Portugal","pnca_p.val125gly","A","-","VAL","VA125","pnca_complex.pdb"
|
|
"V125G","L4","PZA","V","V125",125,"G",1,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",21.367,-1.814,-3.005,3.83404,-3.24,-2.63,70,85,-0.095,5,5,0,0,"loop",0.1,6.12,0.0031622825930717,67.409751924722,67.4093600119011,67.3855171102593,174.918303180059,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-2,0,-1,0,8,0,13,21,-0.459473150962513,-0.776485788113695,0.139644082488946,-0.552429667519182,-0.68848167539267,0.736842105263158,-0.0782537067545305,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","147/150","I:L:V:Q:F:A:E",4.21078388085649,1.83664466117051e-12,0.597583217500306,7.04635564979589,24.5112444006964,278.636893097378,1.82872272889042,2.05851007546474e-28,27.6864470029886,21.4729050424094,338.090551978209,6.23802610818127e-40,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR2864269","ERR2864269","lineage4.3.4.2","pt","Portugal","pnca_p.val125gly","A","-","VAL","VA125","pnca_complex.pdb"
|
|
"V125G","L4","PZA","V","V125",125,"G",NA,"XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",21.367,-1.814,-3.005,3.83404,-3.24,-2.63,70,85,-0.095,5,5,0,0,"loop",0.1,6.12,0.0031622825930717,67.409751924722,67.4093600119011,67.3855171102593,174.918303180059,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-2,0,-1,0,8,0,13,21,-0.459473150962513,-0.776485788113695,0.139644082488946,-0.552429667519182,-0.68848167539267,0.736842105263158,-0.0782537067545305,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","147/150","I:L:V:Q:F:A:E",4.21078388085649,1.83664466117051e-12,0.597583217500306,7.04635564979589,24.5112444006964,278.636893097378,1.82872272889042,2.05851007546474e-28,27.6864470029886,21.4729050424094,338.090551978209,6.23802610818127e-40,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR275212","ERR275212","lineage4.3.4.2","pt","Portugal","pnca_p.val125gly","A","-","VAL","VA125","pnca_complex.pdb"
|
|
"V125G","L4","PZA","V","V125",125,"G",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",21.367,-1.814,-3.005,3.83404,-3.24,-2.63,70,85,-0.095,5,5,0,0,"loop",0.1,6.12,0.0031622825930717,67.409751924722,67.4093600119011,67.3855171102593,174.918303180059,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-2,0,-1,0,8,0,13,21,-0.459473150962513,-0.776485788113695,0.139644082488946,-0.552429667519182,-0.68848167539267,0.736842105263158,-0.0782537067545305,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","147/150","I:L:V:Q:F:A:E",4.21078388085649,1.83664466117051e-12,0.597583217500306,7.04635564979589,24.5112444006964,278.636893097378,1.82872272889042,2.05851007546474e-28,27.6864470029886,21.4729050424094,338.090551978209,6.23802610818127e-40,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR275211","ERR275211","lineage4.3.4.2","pt","Portugal","pnca_p.val125gly","A","-","VAL","VA125","pnca_complex.pdb"
|
|
"V125G","L4","PZA","V","V125",125,"G",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",21.367,-1.814,-3.005,3.83404,-3.24,-2.63,70,85,-0.095,5,5,0,0,"loop",0.1,6.12,0.0031622825930717,67.409751924722,67.4093600119011,67.3855171102593,174.918303180059,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-2,0,-1,0,8,0,13,21,-0.459473150962513,-0.776485788113695,0.139644082488946,-0.552429667519182,-0.68848167539267,0.736842105263158,-0.0782537067545305,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","147/150","I:L:V:Q:F:A:E",4.21078388085649,1.83664466117051e-12,0.597583217500306,7.04635564979589,24.5112444006964,278.636893097378,1.82872272889042,2.05851007546474e-28,27.6864470029886,21.4729050424094,338.090551978209,6.23802610818127e-40,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR1036282","ERR1036282","lineage4.3.4.2","pt","Portugal","pnca_p.val125gly","A","-","VAL","VA125","pnca_complex.pdb"
|
|
"V125G","L4","PZA","V","V125",125,"G",1,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",21.367,-1.814,-3.005,3.83404,-3.24,-2.63,70,85,-0.095,5,5,0,0,"loop",0.1,6.12,0.0031622825930717,67.409751924722,67.4093600119011,67.3855171102593,174.918303180059,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-2,0,-1,0,8,0,13,21,-0.459473150962513,-0.776485788113695,0.139644082488946,-0.552429667519182,-0.68848167539267,0.736842105263158,-0.0782537067545305,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","147/150","I:L:V:Q:F:A:E",4.21078388085649,1.83664466117051e-12,0.597583217500306,7.04635564979589,24.5112444006964,278.636893097378,1.82872272889042,2.05851007546474e-28,27.6864470029886,21.4729050424094,338.090551978209,6.23802610818127e-40,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR2864289","ERR2864289","lineage4.3.4.2","pt","Portugal","pnca_p.val125gly","A","-","VAL","VA125","pnca_complex.pdb"
|
|
"V125G","L4","PZA","V","V125",125,"G",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",21.367,-1.814,-3.005,3.83404,-3.24,-2.63,70,85,-0.095,5,5,0,0,"loop",0.1,6.12,0.0031622825930717,67.409751924722,67.4093600119011,67.3855171102593,174.918303180059,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-2,0,-1,0,8,0,13,21,-0.459473150962513,-0.776485788113695,0.139644082488946,-0.552429667519182,-0.68848167539267,0.736842105263158,-0.0782537067545305,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","147/150","I:L:V:Q:F:A:E",4.21078388085649,1.83664466117051e-12,0.597583217500306,7.04635564979589,24.5112444006964,278.636893097378,1.82872272889042,2.05851007546474e-28,27.6864470029886,21.4729050424094,338.090551978209,6.23802610818127e-40,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR1034844","ERR1034844","lineage4.3.4.2","pt","Portugal","pnca_p.val125gly","A","-","VAL","VA125","pnca_complex.pdb"
|
|
"V125G","L4","PZA","V","V125",125,"G",1,"XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",21.367,-1.814,-3.005,3.83404,-3.24,-2.63,70,85,-0.095,5,5,0,0,"loop",0.1,6.12,0.0031622825930717,67.409751924722,67.4093600119011,67.3855171102593,174.918303180059,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-2,0,-1,0,8,0,13,21,-0.459473150962513,-0.776485788113695,0.139644082488946,-0.552429667519182,-0.68848167539267,0.736842105263158,-0.0782537067545305,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","147/150","I:L:V:Q:F:A:E",4.21078388085649,1.83664466117051e-12,0.597583217500306,7.04635564979589,24.5112444006964,278.636893097378,1.82872272889042,2.05851007546474e-28,27.6864470029886,21.4729050424094,338.090551978209,6.23802610818127e-40,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR1035237","ERR1035237","lineage4.3.4.2","pt","Portugal","pnca_p.val125gly","A","-","VAL","VA125","pnca_complex.pdb"
|
|
"V125G","L4","PZA","V","V125",125,"G",1,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",21.367,-1.814,-3.005,3.83404,-3.24,-2.63,70,85,-0.095,5,5,0,0,"loop",0.1,6.12,0.0031622825930717,67.409751924722,67.4093600119011,67.3855171102593,174.918303180059,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-2,0,-1,0,8,0,13,21,-0.459473150962513,-0.776485788113695,0.139644082488946,-0.552429667519182,-0.68848167539267,0.736842105263158,-0.0782537067545305,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","147/150","I:L:V:Q:F:A:E",4.21078388085649,1.83664466117051e-12,0.597583217500306,7.04635564979589,24.5112444006964,278.636893097378,1.82872272889042,2.05851007546474e-28,27.6864470029886,21.4729050424094,338.090551978209,6.23802610818127e-40,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR2864288","ERR2864288","lineage4.3.4.2","pt","Portugal","pnca_p.val125gly","A","-","VAL","VA125","pnca_complex.pdb"
|
|
"V125G","L4","PZA","V","V125",125,"G",1,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",21.367,-1.814,-3.005,3.83404,-3.24,-2.63,70,85,-0.095,5,5,0,0,"loop",0.1,6.12,0.0031622825930717,67.409751924722,67.4093600119011,67.3855171102593,174.918303180059,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-2,0,-1,0,8,0,13,21,-0.459473150962513,-0.776485788113695,0.139644082488946,-0.552429667519182,-0.68848167539267,0.736842105263158,-0.0782537067545305,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","147/150","I:L:V:Q:F:A:E",4.21078388085649,1.83664466117051e-12,0.597583217500306,7.04635564979589,24.5112444006964,278.636893097378,1.82872272889042,2.05851007546474e-28,27.6864470029886,21.4729050424094,338.090551978209,6.23802610818127e-40,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR1034911","ERR1034911","lineage4.3.4.2;lineage4.3.3","pt","Portugal","pnca_p.val125gly","A","-","VAL","VA125","pnca_complex.pdb"
|
|
"V125G","L4","PZA","V","V125",125,"G",NA,"XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",21.367,-1.814,-3.005,3.83404,-3.24,-2.63,70,85,-0.095,5,5,0,0,"loop",0.1,6.12,0.0031622825930717,67.409751924722,67.4093600119011,67.3855171102593,174.918303180059,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-2,0,-1,0,8,0,13,21,-0.459473150962513,-0.776485788113695,0.139644082488946,-0.552429667519182,-0.68848167539267,0.736842105263158,-0.0782537067545305,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","147/150","I:L:V:Q:F:A:E",4.21078388085649,1.83664466117051e-12,0.597583217500306,7.04635564979589,24.5112444006964,278.636893097378,1.82872272889042,2.05851007546474e-28,27.6864470029886,21.4729050424094,338.090551978209,6.23802610818127e-40,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR275207","ERR275207","lineage4.3.4.2","pt","Portugal","pnca_p.val125gly","A","-","VAL","VA125","pnca_complex.pdb"
|
|
"V125G","L4","PZA","V","V125",125,"G",1,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",21.367,-1.814,-3.005,3.83404,-3.24,-2.63,70,85,-0.095,5,5,0,0,"loop",0.1,6.12,0.0031622825930717,67.409751924722,67.4093600119011,67.3855171102593,174.918303180059,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-2,0,-1,0,8,0,13,21,-0.459473150962513,-0.776485788113695,0.139644082488946,-0.552429667519182,-0.68848167539267,0.736842105263158,-0.0782537067545305,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","147/150","I:L:V:Q:F:A:E",4.21078388085649,1.83664466117051e-12,0.597583217500306,7.04635564979589,24.5112444006964,278.636893097378,1.82872272889042,2.05851007546474e-28,27.6864470029886,21.4729050424094,338.090551978209,6.23802610818127e-40,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR2864294","ERR2864294","lineage4.3.4.2","pt","Portugal","pnca_p.val125gly","A","-","VAL","VA125","pnca_complex.pdb"
|
|
"V125G","L4","PZA","V","V125",125,"G",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",21.367,-1.814,-3.005,3.83404,-3.24,-2.63,70,85,-0.095,5,5,0,0,"loop",0.1,6.12,0.0031622825930717,67.409751924722,67.4093600119011,67.3855171102593,174.918303180059,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-2,0,-1,0,8,0,13,21,-0.459473150962513,-0.776485788113695,0.139644082488946,-0.552429667519182,-0.68848167539267,0.736842105263158,-0.0782537067545305,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","147/150","I:L:V:Q:F:A:E",4.21078388085649,1.83664466117051e-12,0.597583217500306,7.04635564979589,24.5112444006964,278.636893097378,1.82872272889042,2.05851007546474e-28,27.6864470029886,21.4729050424094,338.090551978209,6.23802610818127e-40,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR1034879","ERR1034879","lineage4.3.4.2","pt","Portugal","pnca_p.val125gly","A","-","VAL","VA125","pnca_complex.pdb"
|
|
"V125G","L4","PZA","V","V125",125,"G",1,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",21.367,-1.814,-3.005,3.83404,-3.24,-2.63,70,85,-0.095,5,5,0,0,"loop",0.1,6.12,0.0031622825930717,67.409751924722,67.4093600119011,67.3855171102593,174.918303180059,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-2,0,-1,0,8,0,13,21,-0.459473150962513,-0.776485788113695,0.139644082488946,-0.552429667519182,-0.68848167539267,0.736842105263158,-0.0782537067545305,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","147/150","I:L:V:Q:F:A:E",4.21078388085649,1.83664466117051e-12,0.597583217500306,7.04635564979589,24.5112444006964,278.636893097378,1.82872272889042,2.05851007546474e-28,27.6864470029886,21.4729050424094,338.090551978209,6.23802610818127e-40,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR1036285","ERR1036285","lineage4.3.4.2","pt","Portugal","pnca_p.val125gly","A","-","VAL","VA125","pnca_complex.pdb"
|
|
"V125G","L4","PZA","V","V125",125,"G",1,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",21.367,-1.814,-3.005,3.83404,-3.24,-2.63,70,85,-0.095,5,5,0,0,"loop",0.1,6.12,0.0031622825930717,67.409751924722,67.4093600119011,67.3855171102593,174.918303180059,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-2,0,-1,0,8,0,13,21,-0.459473150962513,-0.776485788113695,0.139644082488946,-0.552429667519182,-0.68848167539267,0.736842105263158,-0.0782537067545305,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","147/150","I:L:V:Q:F:A:E",4.21078388085649,1.83664466117051e-12,0.597583217500306,7.04635564979589,24.5112444006964,278.636893097378,1.82872272889042,2.05851007546474e-28,27.6864470029886,21.4729050424094,338.090551978209,6.23802610818127e-40,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR1036284","ERR1036284","lineage4.3.4.2","pt","Portugal","pnca_p.val125gly","A","-","VAL","VA125","pnca_complex.pdb"
|
|
"V125G","L4","PZA","V","V125",125,"G",0,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",21.367,-1.814,-3.005,3.83404,-3.24,-2.63,70,85,-0.095,5,5,0,0,"loop",0.1,6.12,0.0031622825930717,67.409751924722,67.4093600119011,67.3855171102593,174.918303180059,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-2,0,-1,0,8,0,13,21,-0.459473150962513,-0.776485788113695,0.139644082488946,-0.552429667519182,-0.68848167539267,0.736842105263158,-0.0782537067545305,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","147/150","I:L:V:Q:F:A:E",4.21078388085649,1.83664466117051e-12,0.597583217500306,7.04635564979589,24.5112444006964,278.636893097378,1.82872272889042,2.05851007546474e-28,27.6864470029886,21.4729050424094,338.090551978209,6.23802610818127e-40,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR2864264","ERR2864264","lineage4.3.4.2","pt","Portugal","pnca_p.val125gly","A","-","VAL","VA125","pnca_complex.pdb"
|
|
"V125G","L4","PZA","V","V125",125,"G",1,"Pre-MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",21.367,-1.814,-3.005,3.83404,-3.24,-2.63,70,85,-0.095,5,5,0,0,"loop",0.1,6.12,0.0031622825930717,67.409751924722,67.4093600119011,67.3855171102593,174.918303180059,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-2,0,-1,0,8,0,13,21,-0.459473150962513,-0.776485788113695,0.139644082488946,-0.552429667519182,-0.68848167539267,0.736842105263158,-0.0782537067545305,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","147/150","I:L:V:Q:F:A:E",4.21078388085649,1.83664466117051e-12,0.597583217500306,7.04635564979589,24.5112444006964,278.636893097378,1.82872272889042,2.05851007546474e-28,27.6864470029886,21.4729050424094,338.090551978209,6.23802610818127e-40,"lineage4","dr_mutations_pyrazinamide","GLY",0,"SRR2469373,SAMN04099730","SRR2469373","lineage4.1.1.3","","","pnca_p.val125gly","A","-","VAL","VA125","pnca_complex.pdb"
|
|
"V125G","L4","PZA","V","V125",125,"G",NA,"XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",21.367,-1.814,-3.005,3.83404,-3.24,-2.63,70,85,-0.095,5,5,0,0,"loop",0.1,6.12,0.0031622825930717,67.409751924722,67.4093600119011,67.3855171102593,174.918303180059,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-2,0,-1,0,8,0,13,21,-0.459473150962513,-0.776485788113695,0.139644082488946,-0.552429667519182,-0.68848167539267,0.736842105263158,-0.0782537067545305,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","147/150","I:L:V:Q:F:A:E",4.21078388085649,1.83664466117051e-12,0.597583217500306,7.04635564979589,24.5112444006964,278.636893097378,1.82872272889042,2.05851007546474e-28,27.6864470029886,21.4729050424094,338.090551978209,6.23802610818127e-40,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR1035186","ERR1035186","lineage4.3.4.2","pt","Portugal","pnca_p.val125gly","A","-","VAL","VA125","pnca_complex.pdb"
|
|
"V125G","L4","PZA","V","V125",125,"G",1,"Pre-MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",21.367,-1.814,-3.005,3.83404,-3.24,-2.63,70,85,-0.095,5,5,0,0,"loop",0.1,6.12,0.0031622825930717,67.409751924722,67.4093600119011,67.3855171102593,174.918303180059,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-2,0,-1,0,8,0,13,21,-0.459473150962513,-0.776485788113695,0.139644082488946,-0.552429667519182,-0.68848167539267,0.736842105263158,-0.0782537067545305,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","147/150","I:L:V:Q:F:A:E",4.21078388085649,1.83664466117051e-12,0.597583217500306,7.04635564979589,24.5112444006964,278.636893097378,1.82872272889042,2.05851007546474e-28,27.6864470029886,21.4729050424094,338.090551978209,6.23802610818127e-40,"lineage4","dr_mutations_pyrazinamide","GLY",0,"SAMN03647562","SRR2100389","lineage4.1.1.3","","","pnca_p.val125gly","A","-","VAL","VA125","pnca_complex.pdb"
|
|
"V125G","L4","PZA","V","V125",125,"G",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",21.367,-1.814,-3.005,3.83404,-3.24,-2.63,70,85,-0.095,5,5,0,0,"loop",0.1,6.12,0.0031622825930717,67.409751924722,67.4093600119011,67.3855171102593,174.918303180059,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-2,0,-1,0,8,0,13,21,-0.459473150962513,-0.776485788113695,0.139644082488946,-0.552429667519182,-0.68848167539267,0.736842105263158,-0.0782537067545305,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","147/150","I:L:V:Q:F:A:E",4.21078388085649,1.83664466117051e-12,0.597583217500306,7.04635564979589,24.5112444006964,278.636893097378,1.82872272889042,2.05851007546474e-28,27.6864470029886,21.4729050424094,338.090551978209,6.23802610818127e-40,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR1213924","ERR1213924","lineage4.3.4.2","pt","Portugal","pnca_p.val125gly","A","-","VAL","VA125","pnca_complex.pdb"
|
|
"V125G","L4","PZA","V","V125",125,"G",1,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",21.367,-1.814,-3.005,3.83404,-3.24,-2.63,70,85,-0.095,5,5,0,0,"loop",0.1,6.12,0.0031622825930717,67.409751924722,67.4093600119011,67.3855171102593,174.918303180059,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-2,0,-1,0,8,0,13,21,-0.459473150962513,-0.776485788113695,0.139644082488946,-0.552429667519182,-0.68848167539267,0.736842105263158,-0.0782537067545305,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","147/150","I:L:V:Q:F:A:E",4.21078388085649,1.83664466117051e-12,0.597583217500306,7.04635564979589,24.5112444006964,278.636893097378,1.82872272889042,2.05851007546474e-28,27.6864470029886,21.4729050424094,338.090551978209,6.23802610818127e-40,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR2864239","ERR2864239","lineage4.3.4.2","pt","Portugal","pnca_p.val125gly","A","-","VAL","VA125","pnca_complex.pdb"
|
|
"V125G","L4","PZA","V","V125",125,"G",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",21.367,-1.814,-3.005,3.83404,-3.24,-2.63,70,85,-0.095,5,5,0,0,"loop",0.1,6.12,0.0031622825930717,67.409751924722,67.4093600119011,67.3855171102593,174.918303180059,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-2,0,-1,0,8,0,13,21,-0.459473150962513,-0.776485788113695,0.139644082488946,-0.552429667519182,-0.68848167539267,0.736842105263158,-0.0782537067545305,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","147/150","I:L:V:Q:F:A:E",4.21078388085649,1.83664466117051e-12,0.597583217500306,7.04635564979589,24.5112444006964,278.636893097378,1.82872272889042,2.05851007546474e-28,27.6864470029886,21.4729050424094,338.090551978209,6.23802610818127e-40,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR3275774","ERR3275774","lineage4.2.2","nl","Netherlands","pnca_p.val125gly","A","-","VAL","VA125","pnca_complex.pdb"
|
|
"V125G","L4","PZA","V","V125",125,"G",1,"XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",21.367,-1.814,-3.005,3.83404,-3.24,-2.63,70,85,-0.095,5,5,0,0,"loop",0.1,6.12,0.0031622825930717,67.409751924722,67.4093600119011,67.3855171102593,174.918303180059,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-2,0,-1,0,8,0,13,21,-0.459473150962513,-0.776485788113695,0.139644082488946,-0.552429667519182,-0.68848167539267,0.736842105263158,-0.0782537067545305,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","147/150","I:L:V:Q:F:A:E",4.21078388085649,1.83664466117051e-12,0.597583217500306,7.04635564979589,24.5112444006964,278.636893097378,1.82872272889042,2.05851007546474e-28,27.6864470029886,21.4729050424094,338.090551978209,6.23802610818127e-40,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR2864283","ERR2864283","lineage4.3.4.2","pt","Portugal","pnca_p.val125gly","A","-","VAL","VA125","pnca_complex.pdb"
|
|
"V125G","L4","PZA","V","V125",125,"G",NA,"XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",21.367,-1.814,-3.005,3.83404,-3.24,-2.63,70,85,-0.095,5,5,0,0,"loop",0.1,6.12,0.0031622825930717,67.409751924722,67.4093600119011,67.3855171102593,174.918303180059,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-2,0,-1,0,8,0,13,21,-0.459473150962513,-0.776485788113695,0.139644082488946,-0.552429667519182,-0.68848167539267,0.736842105263158,-0.0782537067545305,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","147/150","I:L:V:Q:F:A:E",4.21078388085649,1.83664466117051e-12,0.597583217500306,7.04635564979589,24.5112444006964,278.636893097378,1.82872272889042,2.05851007546474e-28,27.6864470029886,21.4729050424094,338.090551978209,6.23802610818127e-40,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR275184","ERR275184","lineage4.3.4.2","pt","Portugal","pnca_p.val125gly","A","-","VAL","VA125","pnca_complex.pdb"
|
|
"V125G","L4","PZA","V","V125",125,"G",1,"XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",21.367,-1.814,-3.005,3.83404,-3.24,-2.63,70,85,-0.095,5,5,0,0,"loop",0.1,6.12,0.0031622825930717,67.409751924722,67.4093600119011,67.3855171102593,174.918303180059,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-2,0,-1,0,8,0,13,21,-0.459473150962513,-0.776485788113695,0.139644082488946,-0.552429667519182,-0.68848167539267,0.736842105263158,-0.0782537067545305,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","147/150","I:L:V:Q:F:A:E",4.21078388085649,1.83664466117051e-12,0.597583217500306,7.04635564979589,24.5112444006964,278.636893097378,1.82872272889042,2.05851007546474e-28,27.6864470029886,21.4729050424094,338.090551978209,6.23802610818127e-40,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR1035225","ERR1035225","lineage4.3.4.2","pt","Portugal","pnca_p.val125gly","A","-","VAL","VA125","pnca_complex.pdb"
|
|
"V125G","L4","PZA","V","V125",125,"G",NA,"XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",21.367,-1.814,-3.005,3.83404,-3.24,-2.63,70,85,-0.095,5,5,0,0,"loop",0.1,6.12,0.0031622825930717,67.409751924722,67.4093600119011,67.3855171102593,174.918303180059,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-2,0,-1,0,8,0,13,21,-0.459473150962513,-0.776485788113695,0.139644082488946,-0.552429667519182,-0.68848167539267,0.736842105263158,-0.0782537067545305,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","147/150","I:L:V:Q:F:A:E",4.21078388085649,1.83664466117051e-12,0.597583217500306,7.04635564979589,24.5112444006964,278.636893097378,1.82872272889042,2.05851007546474e-28,27.6864470029886,21.4729050424094,338.090551978209,6.23802610818127e-40,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR1034873","ERR1034873","lineage4.3.4.2","pt","Portugal","pnca_p.val125gly","A","-","VAL","VA125","pnca_complex.pdb"
|
|
"V125G","L4","PZA","V","V125",125,"G",NA,"Pre-MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",21.367,-1.814,-3.005,3.83404,-3.24,-2.63,70,85,-0.095,5,5,0,0,"loop",0.1,6.12,0.0031622825930717,67.409751924722,67.4093600119011,67.3855171102593,174.918303180059,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-2,0,-1,0,8,0,13,21,-0.459473150962513,-0.776485788113695,0.139644082488946,-0.552429667519182,-0.68848167539267,0.736842105263158,-0.0782537067545305,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","147/150","I:L:V:Q:F:A:E",4.21078388085649,1.83664466117051e-12,0.597583217500306,7.04635564979589,24.5112444006964,278.636893097378,1.82872272889042,2.05851007546474e-28,27.6864470029886,21.4729050424094,338.090551978209,6.23802610818127e-40,"lineage4","dr_mutations_pyrazinamide","GLY",0,"SAMN04365146","SRR3055242","lineage4.1.1.3","","","pnca_p.val125gly","A","-","VAL","VA125","pnca_complex.pdb"
|
|
"V125G","L4","PZA","V","V125",125,"G",1,"XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",21.367,-1.814,-3.005,3.83404,-3.24,-2.63,70,85,-0.095,5,5,0,0,"loop",0.1,6.12,0.0031622825930717,67.409751924722,67.4093600119011,67.3855171102593,174.918303180059,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-2,0,-1,0,8,0,13,21,-0.459473150962513,-0.776485788113695,0.139644082488946,-0.552429667519182,-0.68848167539267,0.736842105263158,-0.0782537067545305,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","147/150","I:L:V:Q:F:A:E",4.21078388085649,1.83664466117051e-12,0.597583217500306,7.04635564979589,24.5112444006964,278.636893097378,1.82872272889042,2.05851007546474e-28,27.6864470029886,21.4729050424094,338.090551978209,6.23802610818127e-40,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR1035228","ERR1035228","lineage4.3.4.2","pt","Portugal","pnca_p.val125gly","A","-","VAL","VA125","pnca_complex.pdb"
|
|
"V125G","L4","PZA","V","V125",125,"G",1,"XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",21.367,-1.814,-3.005,3.83404,-3.24,-2.63,70,85,-0.095,5,5,0,0,"loop",0.1,6.12,0.0031622825930717,67.409751924722,67.4093600119011,67.3855171102593,174.918303180059,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-2,0,-1,0,8,0,13,21,-0.459473150962513,-0.776485788113695,0.139644082488946,-0.552429667519182,-0.68848167539267,0.736842105263158,-0.0782537067545305,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","147/150","I:L:V:Q:F:A:E",4.21078388085649,1.83664466117051e-12,0.597583217500306,7.04635564979589,24.5112444006964,278.636893097378,1.82872272889042,2.05851007546474e-28,27.6864470029886,21.4729050424094,338.090551978209,6.23802610818127e-40,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR2864297","ERR2864297","lineage4.3.4.2","pt","Portugal","pnca_p.val125gly","A","-","VAL","VA125","pnca_complex.pdb"
|
|
"V125G","L4","PZA","V","V125",125,"G",1,"XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",21.367,-1.814,-3.005,3.83404,-3.24,-2.63,70,85,-0.095,5,5,0,0,"loop",0.1,6.12,0.0031622825930717,67.409751924722,67.4093600119011,67.3855171102593,174.918303180059,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-2,0,-1,0,8,0,13,21,-0.459473150962513,-0.776485788113695,0.139644082488946,-0.552429667519182,-0.68848167539267,0.736842105263158,-0.0782537067545305,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","147/150","I:L:V:Q:F:A:E",4.21078388085649,1.83664466117051e-12,0.597583217500306,7.04635564979589,24.5112444006964,278.636893097378,1.82872272889042,2.05851007546474e-28,27.6864470029886,21.4729050424094,338.090551978209,6.23802610818127e-40,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR1035194","ERR1035194","lineage4.3.4.2","pt","Portugal","pnca_p.val125gly","A","-","VAL","VA125","pnca_complex.pdb"
|
|
"V125G","L2","PZA","V","V125",125,"G",1,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",21.367,-1.814,-3.005,3.83404,-3.24,-2.63,70,85,-0.095,5,5,0,0,"loop",0.1,6.12,0.0031622825930717,67.409751924722,67.4093600119011,67.3855171102593,174.918303180059,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-2,0,-1,0,8,0,13,21,-0.459473150962513,-0.776485788113695,0.139644082488946,-0.552429667519182,-0.68848167539267,0.736842105263158,-0.0782537067545305,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","147/150","I:L:V:Q:F:A:E",4.21078388085649,1.83664466117051e-12,0.597583217500306,7.04635564979589,24.5112444006964,278.636893097378,1.82872272889042,2.05851007546474e-28,27.6864470029886,21.4729050424094,338.090551978209,6.23802610818127e-40,"lineage2","dr_mutations_pyrazinamide","GLY",0,"ERR551159,SAMEA2533743,ERS457145","ERR551159","lineage2.2.1","uz","Uzbekistan,Nukus","pnca_p.val125gly","A","-","VAL","VA125","pnca_complex.pdb"
|
|
"V125G","L4","PZA","V","V125",125,"G",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",21.367,-1.814,-3.005,3.83404,-3.24,-2.63,70,85,-0.095,5,5,0,0,"loop",0.1,6.12,0.0031622825930717,67.409751924722,67.4093600119011,67.3855171102593,174.918303180059,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-2,0,-1,0,8,0,13,21,-0.459473150962513,-0.776485788113695,0.139644082488946,-0.552429667519182,-0.68848167539267,0.736842105263158,-0.0782537067545305,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","147/150","I:L:V:Q:F:A:E",4.21078388085649,1.83664466117051e-12,0.597583217500306,7.04635564979589,24.5112444006964,278.636893097378,1.82872272889042,2.05851007546474e-28,27.6864470029886,21.4729050424094,338.090551978209,6.23802610818127e-40,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR1036295","ERR1036295","lineage4.3.4.2","pt","Portugal","pnca_p.val125gly","A","-","VAL","VA125","pnca_complex.pdb"
|
|
"V125G","L4","PZA","V","V125",125,"G",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",21.367,-1.814,-3.005,3.83404,-3.24,-2.63,70,85,-0.095,5,5,0,0,"loop",0.1,6.12,0.0031622825930717,67.409751924722,67.4093600119011,67.3855171102593,174.918303180059,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-2,0,-1,0,8,0,13,21,-0.459473150962513,-0.776485788113695,0.139644082488946,-0.552429667519182,-0.68848167539267,0.736842105263158,-0.0782537067545305,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","147/150","I:L:V:Q:F:A:E",4.21078388085649,1.83664466117051e-12,0.597583217500306,7.04635564979589,24.5112444006964,278.636893097378,1.82872272889042,2.05851007546474e-28,27.6864470029886,21.4729050424094,338.090551978209,6.23802610818127e-40,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR275222","ERR275222","lineage4.3.4.2","pt","Portugal","pnca_p.val125gly","A","-","VAL","VA125","pnca_complex.pdb"
|
|
"V125G","L4","PZA","V","V125",125,"G",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",21.367,-1.814,-3.005,3.83404,-3.24,-2.63,70,85,-0.095,5,5,0,0,"loop",0.1,6.12,0.0031622825930717,67.409751924722,67.4093600119011,67.3855171102593,174.918303180059,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-2,0,-1,0,8,0,13,21,-0.459473150962513,-0.776485788113695,0.139644082488946,-0.552429667519182,-0.68848167539267,0.736842105263158,-0.0782537067545305,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","147/150","I:L:V:Q:F:A:E",4.21078388085649,1.83664466117051e-12,0.597583217500306,7.04635564979589,24.5112444006964,278.636893097378,1.82872272889042,2.05851007546474e-28,27.6864470029886,21.4729050424094,338.090551978209,6.23802610818127e-40,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR275227","ERR275227","lineage4.3.4.2","pt","Portugal","pnca_p.val125gly","A","-","VAL","VA125","pnca_complex.pdb"
|
|
"V125G","L4","PZA","V","V125",125,"G",NA,"XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",21.367,-1.814,-3.005,3.83404,-3.24,-2.63,70,85,-0.095,5,5,0,0,"loop",0.1,6.12,0.0031622825930717,67.409751924722,67.4093600119011,67.3855171102593,174.918303180059,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-2,0,-1,0,8,0,13,21,-0.459473150962513,-0.776485788113695,0.139644082488946,-0.552429667519182,-0.68848167539267,0.736842105263158,-0.0782537067545305,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","147/150","I:L:V:Q:F:A:E",4.21078388085649,1.83664466117051e-12,0.597583217500306,7.04635564979589,24.5112444006964,278.636893097378,1.82872272889042,2.05851007546474e-28,27.6864470029886,21.4729050424094,338.090551978209,6.23802610818127e-40,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR1034823","ERR1034823","lineage4.3.4.2","pt","Portugal","pnca_p.val125gly","A","-","VAL","VA125","pnca_complex.pdb"
|
|
"V125G","L4","PZA","V","V125",125,"G",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",21.367,-1.814,-3.005,3.83404,-3.24,-2.63,70,85,-0.095,5,5,0,0,"loop",0.1,6.12,0.0031622825930717,67.409751924722,67.4093600119011,67.3855171102593,174.918303180059,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-2,0,-1,0,8,0,13,21,-0.459473150962513,-0.776485788113695,0.139644082488946,-0.552429667519182,-0.68848167539267,0.736842105263158,-0.0782537067545305,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","147/150","I:L:V:Q:F:A:E",4.21078388085649,1.83664466117051e-12,0.597583217500306,7.04635564979589,24.5112444006964,278.636893097378,1.82872272889042,2.05851007546474e-28,27.6864470029886,21.4729050424094,338.090551978209,6.23802610818127e-40,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR1035187","ERR1035187","lineage4.3.4.2","pt","Portugal","pnca_p.val125gly","A","-","VAL","VA125","pnca_complex.pdb"
|
|
"V125G","L4","PZA","V","V125",125,"G",NA,"XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",21.367,-1.814,-3.005,3.83404,-3.24,-2.63,70,85,-0.095,5,5,0,0,"loop",0.1,6.12,0.0031622825930717,67.409751924722,67.4093600119011,67.3855171102593,174.918303180059,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-2,0,-1,0,8,0,13,21,-0.459473150962513,-0.776485788113695,0.139644082488946,-0.552429667519182,-0.68848167539267,0.736842105263158,-0.0782537067545305,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","147/150","I:L:V:Q:F:A:E",4.21078388085649,1.83664466117051e-12,0.597583217500306,7.04635564979589,24.5112444006964,278.636893097378,1.82872272889042,2.05851007546474e-28,27.6864470029886,21.4729050424094,338.090551978209,6.23802610818127e-40,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR1034902","ERR1034902","lineage4.3.4.2","pt","Portugal","pnca_p.val125gly","A","-","VAL","VA125","pnca_complex.pdb"
|
|
"V125G","L4","PZA","V","V125",125,"G",0,"Pre-MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",21.367,-1.814,-3.005,3.83404,-3.24,-2.63,70,85,-0.095,5,5,0,0,"loop",0.1,6.12,0.0031622825930717,67.409751924722,67.4093600119011,67.3855171102593,174.918303180059,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-2,0,-1,0,8,0,13,21,-0.459473150962513,-0.776485788113695,0.139644082488946,-0.552429667519182,-0.68848167539267,0.736842105263158,-0.0782537067545305,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","147/150","I:L:V:Q:F:A:E",4.21078388085649,1.83664466117051e-12,0.597583217500306,7.04635564979589,24.5112444006964,278.636893097378,1.82872272889042,2.05851007546474e-28,27.6864470029886,21.4729050424094,338.090551978209,6.23802610818127e-40,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR2513944","ERR2513944","lineage4.1.1.3","gb","UK","pnca_p.val125gly","A","-","VAL","VA125","pnca_complex.pdb"
|
|
"V125G","L4","PZA","V","V125",125,"G",1,"XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",21.367,-1.814,-3.005,3.83404,-3.24,-2.63,70,85,-0.095,5,5,0,0,"loop",0.1,6.12,0.0031622825930717,67.409751924722,67.4093600119011,67.3855171102593,174.918303180059,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-2,0,-1,0,8,0,13,21,-0.459473150962513,-0.776485788113695,0.139644082488946,-0.552429667519182,-0.68848167539267,0.736842105263158,-0.0782537067545305,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","147/150","I:L:V:Q:F:A:E",4.21078388085649,1.83664466117051e-12,0.597583217500306,7.04635564979589,24.5112444006964,278.636893097378,1.82872272889042,2.05851007546474e-28,27.6864470029886,21.4729050424094,338.090551978209,6.23802610818127e-40,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR2864271","ERR2864271","lineage4.3.4.2","pt","Portugal","pnca_p.val125gly","A","-","VAL","VA125","pnca_complex.pdb"
|
|
"V125G","L4","PZA","V","V125",125,"G",NA,"Pre-MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",21.367,-1.814,-3.005,3.83404,-3.24,-2.63,70,85,-0.095,5,5,0,0,"loop",0.1,6.12,0.0031622825930717,67.409751924722,67.4093600119011,67.3855171102593,174.918303180059,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-2,0,-1,0,8,0,13,21,-0.459473150962513,-0.776485788113695,0.139644082488946,-0.552429667519182,-0.68848167539267,0.736842105263158,-0.0782537067545305,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","147/150","I:L:V:Q:F:A:E",4.21078388085649,1.83664466117051e-12,0.597583217500306,7.04635564979589,24.5112444006964,278.636893097378,1.82872272889042,2.05851007546474e-28,27.6864470029886,21.4729050424094,338.090551978209,6.23802610818127e-40,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR1213837","ERR1213837","lineage4.9","kr","South Korea","pnca_p.val125gly","A","-","VAL","VA125","pnca_complex.pdb"
|
|
"V125G","L4","PZA","V","V125",125,"G",NA,"XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",21.367,-1.814,-3.005,3.83404,-3.24,-2.63,70,85,-0.095,5,5,0,0,"loop",0.1,6.12,0.0031622825930717,67.409751924722,67.4093600119011,67.3855171102593,174.918303180059,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-2,0,-1,0,8,0,13,21,-0.459473150962513,-0.776485788113695,0.139644082488946,-0.552429667519182,-0.68848167539267,0.736842105263158,-0.0782537067545305,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","147/150","I:L:V:Q:F:A:E",4.21078388085649,1.83664466117051e-12,0.597583217500306,7.04635564979589,24.5112444006964,278.636893097378,1.82872272889042,2.05851007546474e-28,27.6864470029886,21.4729050424094,338.090551978209,6.23802610818127e-40,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR275224","ERR275224","lineage4.3.4.2","pt","Portugal","pnca_p.val125gly","A","-","VAL","VA125","pnca_complex.pdb"
|
|
"V125G","L4","PZA","V","V125",125,"G",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",21.367,-1.814,-3.005,3.83404,-3.24,-2.63,70,85,-0.095,5,5,0,0,"loop",0.1,6.12,0.0031622825930717,67.409751924722,67.4093600119011,67.3855171102593,174.918303180059,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-2,0,-1,0,8,0,13,21,-0.459473150962513,-0.776485788113695,0.139644082488946,-0.552429667519182,-0.68848167539267,0.736842105263158,-0.0782537067545305,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","147/150","I:L:V:Q:F:A:E",4.21078388085649,1.83664466117051e-12,0.597583217500306,7.04635564979589,24.5112444006964,278.636893097378,1.82872272889042,2.05851007546474e-28,27.6864470029886,21.4729050424094,338.090551978209,6.23802610818127e-40,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR1034894","ERR1034894","lineage4.3.4.2","pt","Portugal","pnca_p.val125gly","A","-","VAL","VA125","pnca_complex.pdb"
|
|
"V125G","L4","PZA","V","V125",125,"G",NA,"XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",21.367,-1.814,-3.005,3.83404,-3.24,-2.63,70,85,-0.095,5,5,0,0,"loop",0.1,6.12,0.0031622825930717,67.409751924722,67.4093600119011,67.3855171102593,174.918303180059,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-2,0,-1,0,8,0,13,21,-0.459473150962513,-0.776485788113695,0.139644082488946,-0.552429667519182,-0.68848167539267,0.736842105263158,-0.0782537067545305,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","147/150","I:L:V:Q:F:A:E",4.21078388085649,1.83664466117051e-12,0.597583217500306,7.04635564979589,24.5112444006964,278.636893097378,1.82872272889042,2.05851007546474e-28,27.6864470029886,21.4729050424094,338.090551978209,6.23802610818127e-40,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR275217","ERR275217","lineage4.3.4.2","pt","Portugal","pnca_p.val125gly","A","-","VAL","VA125","pnca_complex.pdb"
|
|
"V125G","L4","PZA","V","V125",125,"G",1,"XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",21.367,-1.814,-3.005,3.83404,-3.24,-2.63,70,85,-0.095,5,5,0,0,"loop",0.1,6.12,0.0031622825930717,67.409751924722,67.4093600119011,67.3855171102593,174.918303180059,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-2,0,-1,0,8,0,13,21,-0.459473150962513,-0.776485788113695,0.139644082488946,-0.552429667519182,-0.68848167539267,0.736842105263158,-0.0782537067545305,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","147/150","I:L:V:Q:F:A:E",4.21078388085649,1.83664466117051e-12,0.597583217500306,7.04635564979589,24.5112444006964,278.636893097378,1.82872272889042,2.05851007546474e-28,27.6864470029886,21.4729050424094,338.090551978209,6.23802610818127e-40,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR2864253","ERR2864253","lineage4.3.4.2","pt","Portugal","pnca_p.val125gly","A","-","VAL","VA125","pnca_complex.pdb"
|
|
"V125G","L4","PZA","V","V125",125,"G",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",21.367,-1.814,-3.005,3.83404,-3.24,-2.63,70,85,-0.095,5,5,0,0,"loop",0.1,6.12,0.0031622825930717,67.409751924722,67.4093600119011,67.3855171102593,174.918303180059,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-2,0,-1,0,8,0,13,21,-0.459473150962513,-0.776485788113695,0.139644082488946,-0.552429667519182,-0.68848167539267,0.736842105263158,-0.0782537067545305,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","147/150","I:L:V:Q:F:A:E",4.21078388085649,1.83664466117051e-12,0.597583217500306,7.04635564979589,24.5112444006964,278.636893097378,1.82872272889042,2.05851007546474e-28,27.6864470029886,21.4729050424094,338.090551978209,6.23802610818127e-40,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR1034835","ERR1034835","lineage4.3.4.2","pt","Portugal","pnca_p.val125gly","A","-","VAL","VA125","pnca_complex.pdb"
|
|
"V125G","L4","PZA","V","V125",125,"G",1,"XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",21.367,-1.814,-3.005,3.83404,-3.24,-2.63,70,85,-0.095,5,5,0,0,"loop",0.1,6.12,0.0031622825930717,67.409751924722,67.4093600119011,67.3855171102593,174.918303180059,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-2,0,-1,0,8,0,13,21,-0.459473150962513,-0.776485788113695,0.139644082488946,-0.552429667519182,-0.68848167539267,0.736842105263158,-0.0782537067545305,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","147/150","I:L:V:Q:F:A:E",4.21078388085649,1.83664466117051e-12,0.597583217500306,7.04635564979589,24.5112444006964,278.636893097378,1.82872272889042,2.05851007546474e-28,27.6864470029886,21.4729050424094,338.090551978209,6.23802610818127e-40,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR2864225","ERR2864225","lineage4.3.4.2","pt","Portugal","pnca_p.val125gly","A","-","VAL","VA125","pnca_complex.pdb"
|
|
"V125G","L4","PZA","V","V125",125,"G",NA,"XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",21.367,-1.814,-3.005,3.83404,-3.24,-2.63,70,85,-0.095,5,5,0,0,"loop",0.1,6.12,0.0031622825930717,67.409751924722,67.4093600119011,67.3855171102593,174.918303180059,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-2,0,-1,0,8,0,13,21,-0.459473150962513,-0.776485788113695,0.139644082488946,-0.552429667519182,-0.68848167539267,0.736842105263158,-0.0782537067545305,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","147/150","I:L:V:Q:F:A:E",4.21078388085649,1.83664466117051e-12,0.597583217500306,7.04635564979589,24.5112444006964,278.636893097378,1.82872272889042,2.05851007546474e-28,27.6864470029886,21.4729050424094,338.090551978209,6.23802610818127e-40,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR1034886","ERR1034886","lineage4.3.4.2","pt","Portugal","pnca_p.val125gly","A","-","VAL","VA125","pnca_complex.pdb"
|
|
"V125G","L4","PZA","V","V125",125,"G",1,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",21.367,-1.814,-3.005,3.83404,-3.24,-2.63,70,85,-0.095,5,5,0,0,"loop",0.1,6.12,0.0031622825930717,67.409751924722,67.4093600119011,67.3855171102593,174.918303180059,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-2,0,-1,0,8,0,13,21,-0.459473150962513,-0.776485788113695,0.139644082488946,-0.552429667519182,-0.68848167539267,0.736842105263158,-0.0782537067545305,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","147/150","I:L:V:Q:F:A:E",4.21078388085649,1.83664466117051e-12,0.597583217500306,7.04635564979589,24.5112444006964,278.636893097378,1.82872272889042,2.05851007546474e-28,27.6864470029886,21.4729050424094,338.090551978209,6.23802610818127e-40,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR1035203","ERR1035203","lineage4.3.4.2","pt","Portugal","pnca_p.val125gly","A","-","VAL","VA125","pnca_complex.pdb"
|
|
"V125G","L4","PZA","V","V125",125,"G",1,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",21.367,-1.814,-3.005,3.83404,-3.24,-2.63,70,85,-0.095,5,5,0,0,"loop",0.1,6.12,0.0031622825930717,67.409751924722,67.4093600119011,67.3855171102593,174.918303180059,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-2,0,-1,0,8,0,13,21,-0.459473150962513,-0.776485788113695,0.139644082488946,-0.552429667519182,-0.68848167539267,0.736842105263158,-0.0782537067545305,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","147/150","I:L:V:Q:F:A:E",4.21078388085649,1.83664466117051e-12,0.597583217500306,7.04635564979589,24.5112444006964,278.636893097378,1.82872272889042,2.05851007546474e-28,27.6864470029886,21.4729050424094,338.090551978209,6.23802610818127e-40,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR1035234","ERR1035234","lineage4.3.4.2","pt","Portugal","pnca_p.val125gly","A","-","VAL","VA125","pnca_complex.pdb"
|
|
"V125G","L4","PZA","V","V125",125,"G",1,"XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",21.367,-1.814,-3.005,3.83404,-3.24,-2.63,70,85,-0.095,5,5,0,0,"loop",0.1,6.12,0.0031622825930717,67.409751924722,67.4093600119011,67.3855171102593,174.918303180059,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-2,0,-1,0,8,0,13,21,-0.459473150962513,-0.776485788113695,0.139644082488946,-0.552429667519182,-0.68848167539267,0.736842105263158,-0.0782537067545305,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","147/150","I:L:V:Q:F:A:E",4.21078388085649,1.83664466117051e-12,0.597583217500306,7.04635564979589,24.5112444006964,278.636893097378,1.82872272889042,2.05851007546474e-28,27.6864470029886,21.4729050424094,338.090551978209,6.23802610818127e-40,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR2864240","ERR2864240","lineage4.3.4.2","pt","Portugal","pnca_p.val125gly","A","-","VAL","VA125","pnca_complex.pdb"
|
|
"V125G","L4","PZA","V","V125",125,"G",1,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",21.367,-1.814,-3.005,3.83404,-3.24,-2.63,70,85,-0.095,5,5,0,0,"loop",0.1,6.12,0.0031622825930717,67.409751924722,67.4093600119011,67.3855171102593,174.918303180059,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-2,0,-1,0,8,0,13,21,-0.459473150962513,-0.776485788113695,0.139644082488946,-0.552429667519182,-0.68848167539267,0.736842105263158,-0.0782537067545305,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","147/150","I:L:V:Q:F:A:E",4.21078388085649,1.83664466117051e-12,0.597583217500306,7.04635564979589,24.5112444006964,278.636893097378,1.82872272889042,2.05851007546474e-28,27.6864470029886,21.4729050424094,338.090551978209,6.23802610818127e-40,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR1035244","ERR1035244","lineage4.3.4.2","pt","Portugal","pnca_p.val125gly","A","-","VAL","VA125","pnca_complex.pdb"
|
|
"V125G","L4","PZA","V","V125",125,"G",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",21.367,-1.814,-3.005,3.83404,-3.24,-2.63,70,85,-0.095,5,5,0,0,"loop",0.1,6.12,0.0031622825930717,67.409751924722,67.4093600119011,67.3855171102593,174.918303180059,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-2,0,-1,0,8,0,13,21,-0.459473150962513,-0.776485788113695,0.139644082488946,-0.552429667519182,-0.68848167539267,0.736842105263158,-0.0782537067545305,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.332,-0.038,"6:5","147/150","I:L:V:Q:F:A:E",4.21078388085649,1.83664466117051e-12,0.597583217500306,7.04635564979589,24.5112444006964,278.636893097378,1.82872272889042,2.05851007546474e-28,27.6864470029886,21.4729050424094,338.090551978209,6.23802610818127e-40,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR1035220","ERR1035220","lineage4.3.4.2","pt","Portugal","pnca_p.val125gly","A","-","VAL","VA125","pnca_complex.pdb"
|
|
"D126E","L4","PZA","D","D126",126,"E",NA,"Pre-XDR","OM","hydrophilic","hydrophilic","acidic","acidic","neg","neg",23.083,0.035,-0.157,-0.565957,-0.068,-0.55,-71,87,3.12,1,1,66,0.341968911917098,"loop",-0.933333333333333,4.35,NA,NA,NA,NA,NA,-2,2,0,0,2,0,0,0,0,0,0,0,0,0,0,0,0,-1,0,0,-1,0,0,0,-2,0.0156950672645739,-0.0405684754521963,-0.108812773975236,-0.0115942028985507,-0.143979057591623,-0.763440860215054,1,"Stabilising","Destabilising","Stabilising","Destabilising","Destabilising","neutral",1.712,3.125,"1:1","147/150","D:T:M:S:A:G:L:N:V:K:R:H:E:Y:Q",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage4","other_mutations_pyrazinamide","GLU",0,"SAMN01925669","SRR847782_SRR924233","lineage4.3.3","za","South Africa","pnca_p.asp126glu","A","-","ASP","DA126","pnca_complex.pdb"
|
|
"D126E","L4","PZA","D","D126",126,"E",NA,"MDR","OM","hydrophilic","hydrophilic","acidic","acidic","neg","neg",23.083,0.035,-0.157,-0.565957,-0.068,-0.55,-71,87,3.12,1,1,66,0.341968911917098,"loop",-0.933333333333333,4.35,NA,NA,NA,NA,NA,-2,2,0,0,2,0,0,0,0,0,0,0,0,0,0,0,0,-1,0,0,-1,0,0,0,-2,0.0156950672645739,-0.0405684754521963,-0.108812773975236,-0.0115942028985507,-0.143979057591623,-0.763440860215054,1,"Stabilising","Destabilising","Stabilising","Destabilising","Destabilising","neutral",1.712,3.125,"1:1","147/150","D:T:M:S:A:G:L:N:V:K:R:H:E:Y:Q",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage4","other_mutations_pyrazinamide","GLU",0,"SAMN02053741","SRR833149_SRR833067","lineage4.3.3","za","South Africa","pnca_p.asp126glu","A","-","ASP","DA126","pnca_complex.pdb"
|
|
"D126E","L4","PZA","D","D126",126,"E",NA,"Pre-XDR","OM","hydrophilic","hydrophilic","acidic","acidic","neg","neg",23.083,0.035,-0.157,-0.565957,-0.068,-0.55,-71,87,3.12,1,1,66,0.341968911917098,"loop",-0.933333333333333,4.35,NA,NA,NA,NA,NA,-2,2,0,0,2,0,0,0,0,0,0,0,0,0,0,0,0,-1,0,0,-1,0,0,0,-2,0.0156950672645739,-0.0405684754521963,-0.108812773975236,-0.0115942028985507,-0.143979057591623,-0.763440860215054,1,"Stabilising","Destabilising","Stabilising","Destabilising","Destabilising","neutral",1.712,3.125,"1:1","147/150","D:T:M:S:A:G:L:N:V:K:R:H:E:Y:Q",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage4","other_mutations_pyrazinamide","GLU",0,"SAMN02350486","SRR1140955_SRR1019162","lineage4.3.3","za","South Africa","pnca_p.asp126glu","A","-","ASP","DA126","pnca_complex.pdb"
|
|
"D126E","L4","PZA","D","D126",126,"E",NA,"MDR","OM","hydrophilic","hydrophilic","acidic","acidic","neg","neg",23.083,0.035,-0.157,-0.565957,-0.068,-0.55,-71,87,3.12,1,1,66,0.341968911917098,"loop",-0.933333333333333,4.35,NA,NA,NA,NA,NA,-2,2,0,0,2,0,0,0,0,0,0,0,0,0,0,0,0,-1,0,0,-1,0,0,0,-2,0.0156950672645739,-0.0405684754521963,-0.108812773975236,-0.0115942028985507,-0.143979057591623,-0.763440860215054,1,"Stabilising","Destabilising","Stabilising","Destabilising","Destabilising","neutral",1.712,3.125,"1:1","147/150","D:T:M:S:A:G:L:N:V:K:R:H:E:Y:Q",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage4","other_mutations_pyrazinamide","GLU",0,"SAMN02053768","SRR833140_SRR833162","lineage4.3.3","za","South Africa","pnca_p.asp126glu","A","-","ASP","DA126","pnca_complex.pdb"
|
|
"E127D","L4","PZA","E","E127",127,"D",NA,"Pre-XDR","OM","hydrophilic","hydrophilic","acidic","acidic","neg","neg",20.54,-1.005,-1.341,2.77841,-0.674,-1.29,-42,72,0.916,2,2,55,0.246636771300448,"strand",-0.933333333333333,5.17,NA,NA,NA,NA,NA,6,-2,0,0,-2,0,0,0,0,2,0,0,2,0,0,0,0,-3,0,-2,-3,0,0,0,0,-0.254559270516717,-0.346511627906977,0.101195740062209,-0.114919011082694,-0.337696335078534,-0.451612903225806,0.293589743589744,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","neutral",0.59,1.183,"3:1","147/150","D:T:S:G:A:R:K:N:L:Q:H:E",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage4","other_mutations_pyrazinamide","ASP",0,"SAMN02628491","SRR1180156_SRR1172164_SRR1172203_SRR1183110","lineage4.3","ir","Iran","pnca_p.glu127asp","A","E","GLU","EA127","pnca_complex.pdb"
|
|
"E127V","L2","PZA","E","E127",127,"V",NA,"Pre-XDR","OM","hydrophilic","hydrophobic","acidic","non-polar","neg","non-polar",20.54,-2.247,0.454,-0.86796,-0.221,-0.33,12,59,0.916,2,2,55,0.246636771300448,"strand",-0.933333333333333,5.17,NA,NA,NA,NA,NA,14,24,0,4,20,0,0,0,0,2,0,0,2,0,0,0,0,-3,0,-3,0,-2,0,-2,-2,-0.569148936170213,0.386054421768707,-0.166876874567408,-0.0376811594202899,-0.0863874345549738,0.126315789473684,0.293589743589744,"Destabilising","Stabilising","Stabilising","Destabilising","Destabilising","effect",0.59,1.183,"3:1","147/150","D:T:S:G:A:R:K:N:L:Q:H:E",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage2","other_mutations_pyrazinamide","VAL",0,"SRS797287","SRR1723816","lineage2.2.1","cn","China:Guangdong","pnca_p.glu127val","A","E","GLU","EA127","pnca_complex.pdb"
|
|
"V128F","L2","PZA","V","V128",128,"F",1,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",16.575,-2.082,-1.849,2.63855,-1.167,-1.73,58,75,-0.394,6,6,0,0,"strand",-0.933333333333333,8.31,7.18700589334483e-05,9.70142977291842,188179.926264397,Inf,0.763784339928386,-34,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-11,0,-3,-10,-4,0,-2,-8,-0.527355623100304,-0.477777777777778,0.0961017344240561,-0.198976982097187,-0.452879581151832,0.610526315789474,-0.324546952224053,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.553,-0.332,"7:6","147/150","V:L:I:A",12.1451538387252,0.919026337424191,119.468044436157,0.101660271548309,5.01153666069775e-06,NA,0.986835744238421,0.170978870202674,0.767057556984365,0.124324963210678,Inf,0.382146811758261,"lineage2","other_mutations_pyrazinamide","PHE",0,"ERR552933,SAMEA2535011,ERS458413","ERR552933","lineage2.2.1","uz","Nukus","pnca_p.val128phe","A","E","VAL","VA128","pnca_complex.pdb"
|
|
"V128F","L4","PZA","V","V128",128,"F",NA,"MDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",16.575,-2.082,-1.849,2.63855,-1.167,-1.73,58,75,-0.394,6,6,0,0,"strand",-0.933333333333333,8.31,7.18700589334483e-05,9.70142977291842,188179.926264397,Inf,0.763784339928386,-34,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-11,0,-3,-10,-4,0,-2,-8,-0.527355623100304,-0.477777777777778,0.0961017344240561,-0.198976982097187,-0.452879581151832,0.610526315789474,-0.324546952224053,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.553,-0.332,"7:6","147/150","V:L:I:A",12.1451538387252,0.919026337424191,119.468044436157,0.101660271548309,5.01153666069775e-06,NA,0.986835744238421,0.170978870202674,0.767057556984365,0.124324963210678,Inf,0.382146811758261,"lineage4","other_mutations_pyrazinamide","PHE",0,"ERR1199130","ERR1199130","lineage4.6.1.2","ug","Uganda","pnca_p.val128phe","A","E","VAL","VA128","pnca_complex.pdb"
|
|
"V128G","","PZA","V","V128",128,"G",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",16.575,-1.823,-3.564,4.66562,-4.952,-3.82,75,85,-0.394,6,6,0,0,"strand",-0.933333333333333,8.31,0.0010061808250682,29.234474017744,29.2344625578696,29.200882251631,41.8296883276733,16,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,6,0,7,23,-0.461752786220871,-0.920930232558139,0.169932036218213,-0.844330775788576,-1,0.789473684210526,-0.324546952224053,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.553,-0.332,"7:6","147/150","V:L:I:A",3.37534823794128,9.91219225447489e-06,0.763812419492775,4.41908006704415,7.9656644717311,187.959563815878,1.46589528448265,3.94377277607243e-08,7.40408811526751,6.49943487243223,267.206211303594,9.95798685333635e-11,"","dr_mutations_pyrazinamide","GLY",0,"SRR5818412","SRR5818412","","dj","Djibouti","pnca_p.val128gly","A","E","VAL","VA128","pnca_complex.pdb"
|
|
"V128G","L2","PZA","V","V128",128,"G",1,"Pre-MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",16.575,-1.823,-3.564,4.66562,-4.952,-3.82,75,85,-0.394,6,6,0,0,"strand",-0.933333333333333,8.31,0.0010061808250682,29.234474017744,29.2344625578696,29.200882251631,41.8296883276733,16,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,6,0,7,23,-0.461752786220871,-0.920930232558139,0.169932036218213,-0.844330775788576,-1,0.789473684210526,-0.324546952224053,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.553,-0.332,"7:6","147/150","V:L:I:A",3.37534823794128,9.91219225447489e-06,0.763812419492775,4.41908006704415,7.9656644717311,187.959563815878,1.46589528448265,3.94377277607243e-08,7.40408811526751,6.49943487243223,267.206211303594,9.95798685333635e-11,"lineage2","dr_mutations_pyrazinamide","GLY",0,"ERS457404","ERR551528_ERR551527","lineage2.2.1","uz","Nukus","pnca_p.val128gly","A","E","VAL","VA128","pnca_complex.pdb"
|
|
"V128G","L2","PZA","V","V128",128,"G",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",16.575,-1.823,-3.564,4.66562,-4.952,-3.82,75,85,-0.394,6,6,0,0,"strand",-0.933333333333333,8.31,0.0010061808250682,29.234474017744,29.2344625578696,29.200882251631,41.8296883276733,16,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,6,0,7,23,-0.461752786220871,-0.920930232558139,0.169932036218213,-0.844330775788576,-1,0.789473684210526,-0.324546952224053,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.553,-0.332,"7:6","147/150","V:L:I:A",3.37534823794128,9.91219225447489e-06,0.763812419492775,4.41908006704415,7.9656644717311,187.959563815878,1.46589528448265,3.94377277607243e-08,7.40408811526751,6.49943487243223,267.206211303594,9.95798685333635e-11,"lineage2","dr_mutations_pyrazinamide","GLY",0,"ERR3148180","ERR3148180","lineage2.2.1","mx","Mexico","pnca_p.val128gly","A","E","VAL","VA128","pnca_complex.pdb"
|
|
"V128G","L4","PZA","V","V128",128,"G",1,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",16.575,-1.823,-3.564,4.66562,-4.952,-3.82,75,85,-0.394,6,6,0,0,"strand",-0.933333333333333,8.31,0.0010061808250682,29.234474017744,29.2344625578696,29.200882251631,41.8296883276733,16,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,6,0,7,23,-0.461752786220871,-0.920930232558139,0.169932036218213,-0.844330775788576,-1,0.789473684210526,-0.324546952224053,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.553,-0.332,"7:6","147/150","V:L:I:A",3.37534823794128,9.91219225447489e-06,0.763812419492775,4.41908006704415,7.9656644717311,187.959563815878,1.46589528448265,3.94377277607243e-08,7.40408811526751,6.49943487243223,267.206211303594,9.95798685333635e-11,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR2516955","ERR2516955","lineage4.3.3","gb","UK","pnca_p.val128gly","A","E","VAL","VA128","pnca_complex.pdb"
|
|
"V128G","L2","PZA","V","V128",128,"G",1,"XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",16.575,-1.823,-3.564,4.66562,-4.952,-3.82,75,85,-0.394,6,6,0,0,"strand",-0.933333333333333,8.31,0.0010061808250682,29.234474017744,29.2344625578696,29.200882251631,41.8296883276733,16,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,6,0,7,23,-0.461752786220871,-0.920930232558139,0.169932036218213,-0.844330775788576,-1,0.789473684210526,-0.324546952224053,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.553,-0.332,"7:6","147/150","V:L:I:A",3.37534823794128,9.91219225447489e-06,0.763812419492775,4.41908006704415,7.9656644717311,187.959563815878,1.46589528448265,3.94377277607243e-08,7.40408811526751,6.49943487243223,267.206211303594,9.95798685333635e-11,"lineage2","dr_mutations_pyrazinamide","GLY",0,"ERR067644,0944C-sc-2011-09-07T13:19:28Z-1276491","ERR067644","lineage2.2.1","ru","Russia,Samara","pnca_p.val128gly","A","E","VAL","VA128","pnca_complex.pdb"
|
|
"V128G","L2","PZA","V","V128",128,"G",1,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",16.575,-1.823,-3.564,4.66562,-4.952,-3.82,75,85,-0.394,6,6,0,0,"strand",-0.933333333333333,8.31,0.0010061808250682,29.234474017744,29.2344625578696,29.200882251631,41.8296883276733,16,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,6,0,7,23,-0.461752786220871,-0.920930232558139,0.169932036218213,-0.844330775788576,-1,0.789473684210526,-0.324546952224053,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.553,-0.332,"7:6","147/150","V:L:I:A",3.37534823794128,9.91219225447489e-06,0.763812419492775,4.41908006704415,7.9656644717311,187.959563815878,1.46589528448265,3.94377277607243e-08,7.40408811526751,6.49943487243223,267.206211303594,9.95798685333635e-11,"lineage2","dr_mutations_pyrazinamide","GLY",0,"ERR2514422","ERR2514422","lineage2.2.1","gb","UK","pnca_p.val128gly","A","E","VAL","VA128","pnca_complex.pdb"
|
|
"V128G","L2","PZA","V","V128",128,"G",NA,"XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",16.575,-1.823,-3.564,4.66562,-4.952,-3.82,75,85,-0.394,6,6,0,0,"strand",-0.933333333333333,8.31,0.0010061808250682,29.234474017744,29.2344625578696,29.200882251631,41.8296883276733,16,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,6,0,7,23,-0.461752786220871,-0.920930232558139,0.169932036218213,-0.844330775788576,-1,0.789473684210526,-0.324546952224053,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.553,-0.332,"7:6","147/150","V:L:I:A",3.37534823794128,9.91219225447489e-06,0.763812419492775,4.41908006704415,7.9656644717311,187.959563815878,1.46589528448265,3.94377277607243e-08,7.40408811526751,6.49943487243223,267.206211303594,9.95798685333635e-11,"lineage2","dr_mutations_pyrazinamide","GLY",0,"ERR234644,0056M-sc-2012-10-11T13:37:16Z-1494130","ERR234644","lineage2.2.1","ru","Russia","pnca_p.val128gly","A","E","VAL","VA128","pnca_complex.pdb"
|
|
"V128G","L4","PZA","V","V128",128,"G",0,"Pre-MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",16.575,-1.823,-3.564,4.66562,-4.952,-3.82,75,85,-0.394,6,6,0,0,"strand",-0.933333333333333,8.31,0.0010061808250682,29.234474017744,29.2344625578696,29.200882251631,41.8296883276733,16,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,6,0,7,23,-0.461752786220871,-0.920930232558139,0.169932036218213,-0.844330775788576,-1,0.789473684210526,-0.324546952224053,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.553,-0.332,"7:6","147/150","V:L:I:A",3.37534823794128,9.91219225447489e-06,0.763812419492775,4.41908006704415,7.9656644717311,187.959563815878,1.46589528448265,3.94377277607243e-08,7.40408811526751,6.49943487243223,267.206211303594,9.95798685333635e-11,"lineage4","dr_mutations_pyrazinamide","GLY",0,"1919M-sc-2012-02-21T11:38:06Z-1364835,ERR144598","ERR144598","lineage4.2.1","ru","Russia","pnca_p.val128gly","A","E","VAL","VA128","pnca_complex.pdb"
|
|
"V128G","L2","PZA","V","V128",128,"G",1,"XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",16.575,-1.823,-3.564,4.66562,-4.952,-3.82,75,85,-0.394,6,6,0,0,"strand",-0.933333333333333,8.31,0.0010061808250682,29.234474017744,29.2344625578696,29.200882251631,41.8296883276733,16,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,6,0,7,23,-0.461752786220871,-0.920930232558139,0.169932036218213,-0.844330775788576,-1,0.789473684210526,-0.324546952224053,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.553,-0.332,"7:6","147/150","V:L:I:A",3.37534823794128,9.91219225447489e-06,0.763812419492775,4.41908006704415,7.9656644717311,187.959563815878,1.46589528448265,3.94377277607243e-08,7.40408811526751,6.49943487243223,267.206211303594,9.95798685333635e-11,"lineage2","dr_mutations_pyrazinamide","GLY",0,"1904W-sc-2012-02-21T11:38:04Z-1364832,ERR144595","ERR144595","lineage2.2.1","ru","Russia,Samara","pnca_p.val128gly","A","E","VAL","VA128","pnca_complex.pdb"
|
|
"V128G","L2","PZA","V","V128",128,"G",1,"XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",16.575,-1.823,-3.564,4.66562,-4.952,-3.82,75,85,-0.394,6,6,0,0,"strand",-0.933333333333333,8.31,0.0010061808250682,29.234474017744,29.2344625578696,29.200882251631,41.8296883276733,16,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,6,0,7,23,-0.461752786220871,-0.920930232558139,0.169932036218213,-0.844330775788576,-1,0.789473684210526,-0.324546952224053,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.553,-0.332,"7:6","147/150","V:L:I:A",3.37534823794128,9.91219225447489e-06,0.763812419492775,4.41908006704415,7.9656644717311,187.959563815878,1.46589528448265,3.94377277607243e-08,7.40408811526751,6.49943487243223,267.206211303594,9.95798685333635e-11,"lineage2","dr_mutations_pyrazinamide","GLY",0,"ERR117464,1523G-sc-2011-10-12T14:59:51Z-1289198","ERR117464","lineage2.2.1","ru","Russia,Samara","pnca_p.val128gly","A","E","VAL","VA128","pnca_complex.pdb"
|
|
"V128G","L2","PZA","V","V128",128,"G",1,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",16.575,-1.823,-3.564,4.66562,-4.952,-3.82,75,85,-0.394,6,6,0,0,"strand",-0.933333333333333,8.31,0.0010061808250682,29.234474017744,29.2344625578696,29.200882251631,41.8296883276733,16,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,6,0,7,23,-0.461752786220871,-0.920930232558139,0.169932036218213,-0.844330775788576,-1,0.789473684210526,-0.324546952224053,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.553,-0.332,"7:6","147/150","V:L:I:A",3.37534823794128,9.91219225447489e-06,0.763812419492775,4.41908006704415,7.9656644717311,187.959563815878,1.46589528448265,3.94377277607243e-08,7.40408811526751,6.49943487243223,267.206211303594,9.95798685333635e-11,"lineage2","dr_mutations_pyrazinamide","GLY",0,"ERR027456","ERR027456","lineage2.2.1","ru","Russia","pnca_p.val128gly","A","E","VAL","VA128","pnca_complex.pdb"
|
|
"V128G","L4","PZA","V","V128",128,"G",1,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",16.575,-1.823,-3.564,4.66562,-4.952,-3.82,75,85,-0.394,6,6,0,0,"strand",-0.933333333333333,8.31,0.0010061808250682,29.234474017744,29.2344625578696,29.200882251631,41.8296883276733,16,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,6,0,7,23,-0.461752786220871,-0.920930232558139,0.169932036218213,-0.844330775788576,-1,0.789473684210526,-0.324546952224053,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.553,-0.332,"7:6","147/150","V:L:I:A",3.37534823794128,9.91219225447489e-06,0.763812419492775,4.41908006704415,7.9656644717311,187.959563815878,1.46589528448265,3.94377277607243e-08,7.40408811526751,6.49943487243223,267.206211303594,9.95798685333635e-11,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR2516434","ERR2516434","lineage4.1","pe","Peru","pnca_p.val128gly","A","E","VAL","VA128","pnca_complex.pdb"
|
|
"V128G","L2","PZA","V","V128",128,"G",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",16.575,-1.823,-3.564,4.66562,-4.952,-3.82,75,85,-0.394,6,6,0,0,"strand",-0.933333333333333,8.31,0.0010061808250682,29.234474017744,29.2344625578696,29.200882251631,41.8296883276733,16,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,6,0,7,23,-0.461752786220871,-0.920930232558139,0.169932036218213,-0.844330775788576,-1,0.789473684210526,-0.324546952224053,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.553,-0.332,"7:6","147/150","V:L:I:A",3.37534823794128,9.91219225447489e-06,0.763812419492775,4.41908006704415,7.9656644717311,187.959563815878,1.46589528448265,3.94377277607243e-08,7.40408811526751,6.49943487243223,267.206211303594,9.95798685333635e-11,"lineage2","dr_mutations_pyrazinamide","GLY",0,"ERR015614","ERR015614","lineage2.2.1","ru","Russia","pnca_p.val128gly","A","E","VAL","VA128","pnca_complex.pdb"
|
|
"V128G","L4","PZA","V","V128",128,"G",0,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",16.575,-1.823,-3.564,4.66562,-4.952,-3.82,75,85,-0.394,6,6,0,0,"strand",-0.933333333333333,8.31,0.0010061808250682,29.234474017744,29.2344625578696,29.200882251631,41.8296883276733,16,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,6,0,7,23,-0.461752786220871,-0.920930232558139,0.169932036218213,-0.844330775788576,-1,0.789473684210526,-0.324546952224053,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.553,-0.332,"7:6","147/150","V:L:I:A",3.37534823794128,9.91219225447489e-06,0.763812419492775,4.41908006704415,7.9656644717311,187.959563815878,1.46589528448265,3.94377277607243e-08,7.40408811526751,6.49943487243223,267.206211303594,9.95798685333635e-11,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR2517040","ERR2517040","lineage4.3.3","gb","UK","pnca_p.val128gly","A","E","VAL","VA128","pnca_complex.pdb"
|
|
"V128G","L2","PZA","V","V128",128,"G",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",16.575,-1.823,-3.564,4.66562,-4.952,-3.82,75,85,-0.394,6,6,0,0,"strand",-0.933333333333333,8.31,0.0010061808250682,29.234474017744,29.2344625578696,29.200882251631,41.8296883276733,16,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,6,0,7,23,-0.461752786220871,-0.920930232558139,0.169932036218213,-0.844330775788576,-1,0.789473684210526,-0.324546952224053,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.553,-0.332,"7:6","147/150","V:L:I:A",3.37534823794128,9.91219225447489e-06,0.763812419492775,4.41908006704415,7.9656644717311,187.959563815878,1.46589528448265,3.94377277607243e-08,7.40408811526751,6.49943487243223,267.206211303594,9.95798685333635e-11,"lineage2","dr_mutations_pyrazinamide","GLY",0,"ERR1023416","ERR1023416","lineage2.2.1","","","pnca_p.val128gly","A","E","VAL","VA128","pnca_complex.pdb"
|
|
"V128G","L3","PZA","V","V128",128,"G",1,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",16.575,-1.823,-3.564,4.66562,-4.952,-3.82,75,85,-0.394,6,6,0,0,"strand",-0.933333333333333,8.31,0.0010061808250682,29.234474017744,29.2344625578696,29.200882251631,41.8296883276733,16,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,6,0,7,23,-0.461752786220871,-0.920930232558139,0.169932036218213,-0.844330775788576,-1,0.789473684210526,-0.324546952224053,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.553,-0.332,"7:6","147/150","V:L:I:A",3.37534823794128,9.91219225447489e-06,0.763812419492775,4.41908006704415,7.9656644717311,187.959563815878,1.46589528448265,3.94377277607243e-08,7.40408811526751,6.49943487243223,267.206211303594,9.95798685333635e-11,"lineage3","dr_mutations_pyrazinamide","GLY",0,"ERR2510294","ERR2510294","lineage3","pk","Pakistan","pnca_p.val128gly","A","E","VAL","VA128","pnca_complex.pdb"
|
|
"V128G","L4","PZA","V","V128",128,"G",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",16.575,-1.823,-3.564,4.66562,-4.952,-3.82,75,85,-0.394,6,6,0,0,"strand",-0.933333333333333,8.31,0.0010061808250682,29.234474017744,29.2344625578696,29.200882251631,41.8296883276733,16,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,6,0,7,23,-0.461752786220871,-0.920930232558139,0.169932036218213,-0.844330775788576,-1,0.789473684210526,-0.324546952224053,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.553,-0.332,"7:6","147/150","V:L:I:A",3.37534823794128,9.91219225447489e-06,0.763812419492775,4.41908006704415,7.9656644717311,187.959563815878,1.46589528448265,3.94377277607243e-08,7.40408811526751,6.49943487243223,267.206211303594,9.95798685333635e-11,"lineage4","dr_mutations_pyrazinamide","GLY",0,"SRR5818574","SRR5818574","lineage4.6","dj","Djibouti","pnca_p.val128gly","A","E","VAL","VA128","pnca_complex.pdb"
|
|
"V128G","L4","PZA","V","V128",128,"G",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",16.575,-1.823,-3.564,4.66562,-4.952,-3.82,75,85,-0.394,6,6,0,0,"strand",-0.933333333333333,8.31,0.0010061808250682,29.234474017744,29.2344625578696,29.200882251631,41.8296883276733,16,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,6,0,7,23,-0.461752786220871,-0.920930232558139,0.169932036218213,-0.844330775788576,-1,0.789473684210526,-0.324546952224053,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.553,-0.332,"7:6","147/150","V:L:I:A",3.37534823794128,9.91219225447489e-06,0.763812419492775,4.41908006704415,7.9656644717311,187.959563815878,1.46589528448265,3.94377277607243e-08,7.40408811526751,6.49943487243223,267.206211303594,9.95798685333635e-11,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR1555051","ERR1555051","lineage4.1.1.1","","","pnca_p.val128gly","A","E","VAL","VA128","pnca_complex.pdb"
|
|
"V128G","L4","PZA","V","V128",128,"G",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",16.575,-1.823,-3.564,4.66562,-4.952,-3.82,75,85,-0.394,6,6,0,0,"strand",-0.933333333333333,8.31,0.0010061808250682,29.234474017744,29.2344625578696,29.200882251631,41.8296883276733,16,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,6,0,7,23,-0.461752786220871,-0.920930232558139,0.169932036218213,-0.844330775788576,-1,0.789473684210526,-0.324546952224053,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.553,-0.332,"7:6","147/150","V:L:I:A",3.37534823794128,9.91219225447489e-06,0.763812419492775,4.41908006704415,7.9656644717311,187.959563815878,1.46589528448265,3.94377277607243e-08,7.40408811526751,6.49943487243223,267.206211303594,9.95798685333635e-11,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR2516712","ERR2516712","lineage4.6.1.2","nl","Netherlands","pnca_p.val128gly","A","E","VAL","VA128","pnca_complex.pdb"
|
|
"V128G","L2","PZA","V","V128",128,"G",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",16.575,-1.823,-3.564,4.66562,-4.952,-3.82,75,85,-0.394,6,6,0,0,"strand",-0.933333333333333,8.31,0.0010061808250682,29.234474017744,29.2344625578696,29.200882251631,41.8296883276733,16,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,6,0,7,23,-0.461752786220871,-0.920930232558139,0.169932036218213,-0.844330775788576,-1,0.789473684210526,-0.324546952224053,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.553,-0.332,"7:6","147/150","V:L:I:A",3.37534823794128,9.91219225447489e-06,0.763812419492775,4.41908006704415,7.9656644717311,187.959563815878,1.46589528448265,3.94377277607243e-08,7.40408811526751,6.49943487243223,267.206211303594,9.95798685333635e-11,"lineage2","dr_mutations_pyrazinamide","GLY",0,"SAMN02414937","SRR1166816_SRR1165546_SRR1165521_SRR1162749","lineage2.2.1","se","Sweden","pnca_p.val128gly","A","E","VAL","VA128","pnca_complex.pdb"
|
|
"V128G","L2","PZA","V","V128",128,"G",1,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",16.575,-1.823,-3.564,4.66562,-4.952,-3.82,75,85,-0.394,6,6,0,0,"strand",-0.933333333333333,8.31,0.0010061808250682,29.234474017744,29.2344625578696,29.200882251631,41.8296883276733,16,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,6,0,7,23,-0.461752786220871,-0.920930232558139,0.169932036218213,-0.844330775788576,-1,0.789473684210526,-0.324546952224053,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.553,-0.332,"7:6","147/150","V:L:I:A",3.37534823794128,9.91219225447489e-06,0.763812419492775,4.41908006704415,7.9656644717311,187.959563815878,1.46589528448265,3.94377277607243e-08,7.40408811526751,6.49943487243223,267.206211303594,9.95798685333635e-11,"lineage2","dr_mutations_pyrazinamide","GLY",0,"ERR2512467","ERR2512467","lineage2.2.1","gb","UK","pnca_p.val128gly","A","E","VAL","VA128","pnca_complex.pdb"
|
|
"V128G","L2","PZA","V","V128",128,"G",1,"XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",16.575,-1.823,-3.564,4.66562,-4.952,-3.82,75,85,-0.394,6,6,0,0,"strand",-0.933333333333333,8.31,0.0010061808250682,29.234474017744,29.2344625578696,29.200882251631,41.8296883276733,16,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,6,0,7,23,-0.461752786220871,-0.920930232558139,0.169932036218213,-0.844330775788576,-1,0.789473684210526,-0.324546952224053,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.553,-0.332,"7:6","147/150","V:L:I:A",3.37534823794128,9.91219225447489e-06,0.763812419492775,4.41908006704415,7.9656644717311,187.959563815878,1.46589528448265,3.94377277607243e-08,7.40408811526751,6.49943487243223,267.206211303594,9.95798685333635e-11,"lineage2","dr_mutations_pyrazinamide","GLY",0,"ERR137247,1570H-sc-2012-02-21T11:36:53Z-1364739","ERR137247","lineage2.2.1","ru","Russia,Samara","pnca_p.val128gly","A","E","VAL","VA128","pnca_complex.pdb"
|
|
"V128G","L2","PZA","V","V128",128,"G",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",16.575,-1.823,-3.564,4.66562,-4.952,-3.82,75,85,-0.394,6,6,0,0,"strand",-0.933333333333333,8.31,0.0010061808250682,29.234474017744,29.2344625578696,29.200882251631,41.8296883276733,16,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,6,0,7,23,-0.461752786220871,-0.920930232558139,0.169932036218213,-0.844330775788576,-1,0.789473684210526,-0.324546952224053,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.553,-0.332,"7:6","147/150","V:L:I:A",3.37534823794128,9.91219225447489e-06,0.763812419492775,4.41908006704415,7.9656644717311,187.959563815878,1.46589528448265,3.94377277607243e-08,7.40408811526751,6.49943487243223,267.206211303594,9.95798685333635e-11,"lineage2","dr_mutations_pyrazinamide","GLY",0,"ERR3276267","ERR3276267","lineage2.2.1","nl","Netherlands","pnca_p.val128gly","A","E","VAL","VA128","pnca_complex.pdb"
|
|
"V128G","L4","PZA","V","V128",128,"G",1,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",16.575,-1.823,-3.564,4.66562,-4.952,-3.82,75,85,-0.394,6,6,0,0,"strand",-0.933333333333333,8.31,0.0010061808250682,29.234474017744,29.2344625578696,29.200882251631,41.8296883276733,16,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,6,0,7,23,-0.461752786220871,-0.920930232558139,0.169932036218213,-0.844330775788576,-1,0.789473684210526,-0.324546952224053,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.553,-0.332,"7:6","147/150","V:L:I:A",3.37534823794128,9.91219225447489e-06,0.763812419492775,4.41908006704415,7.9656644717311,187.959563815878,1.46589528448265,3.94377277607243e-08,7.40408811526751,6.49943487243223,267.206211303594,9.95798685333635e-11,"lineage4","dr_mutations_pyrazinamide","GLY",0,"1190V-sc-2011-09-07T13:19:48Z-1276524,ERR067677","ERR067677","lineage4.2.1","ru","Russia,Samara","pnca_p.val128gly","A","E","VAL","VA128","pnca_complex.pdb"
|
|
"D129G","L4","PZA","D","D129",129,"G",0,"MDR","OM","hydrophilic","hydrophobic","acidic","neutral","neg","non-polar",14.781,-3.948,-0.65,4.68356,-2.685,-0.43,77,85,0.074,5,5,0,0,"strand",1.63333333333333,7.77,7.18700589334483e-05,2.42412778478352,0.0001249735077034,0,1.03410070803344e-29,34,36,0,4,32,0,0,0,0,4,0,0,4,0,0,0,0,4,0,0,4,4,0,11,19,-1,-0.167958656330749,0.170585450068838,-0.457800511508951,-0.112565445026178,0.810526315789474,0.0237179487179487,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.147,0.225,"6:4","147/150","I:V:L:E:Y:H:F:D:W:S:A:T",-8.98740878149641,0.940032862253633,119.468044435492,-0.0752285585987749,NA,4692673.51081121,0.384555509373631,1,0,0,188.544222231268,0.999999999999997,"lineage4","other_mutations_pyrazinamide","GLY",0,"ERR2516980","ERR2516980","lineage4.8","gb","UK","pnca_p.asp129gly","A","E","ASP","DA129","pnca_complex.pdb"
|
|
"D129G","L4","PZA","D","D129",129,"G",NA,"MDR","OM","hydrophilic","hydrophobic","acidic","neutral","neg","non-polar",14.781,-3.948,-0.65,4.68356,-2.685,-0.43,77,85,0.074,5,5,0,0,"strand",1.63333333333333,7.77,7.18700589334483e-05,2.42412778478352,0.0001249735077034,0,1.03410070803344e-29,34,36,0,4,32,0,0,0,0,4,0,0,4,0,0,0,0,4,0,0,4,4,0,11,19,-1,-0.167958656330749,0.170585450068838,-0.457800511508951,-0.112565445026178,0.810526315789474,0.0237179487179487,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.147,0.225,"6:4","147/150","I:V:L:E:Y:H:F:D:W:S:A:T",-8.98740878149641,0.940032862253633,119.468044435492,-0.0752285585987749,NA,4692673.51081121,0.384555509373631,1,0,0,188.544222231268,0.999999999999997,"lineage4","other_mutations_pyrazinamide","GLY",0,"ERR760839","ERR760839","lineage4.1.2.1","ar","Argentina","pnca_p.asp129gly","A","E","ASP","DA129","pnca_complex.pdb"
|
|
"D129N","L4","PZA","D","D129",129,"N",NA,"Sensitive","OM","hydrophilic","hydrophilic","acidic","neutral","neg","polar",14.781,-3.245,-0.735,1.83782,-2.127,-0.87,72,85,0.074,5,5,0,0,"strand",1.63333333333333,7.77,7.18700589334483e-05,2.42412778478352,0.0001249735077034,0,1.03410070803344e-29,-2,38,0,4,34,0,0,0,0,-2,0,-2,0,0,0,0,0,0,0,-1,0,0,0,2,0,-0.82193515704154,-0.189922480620155,0.0669374048470633,-0.362659846547315,-0.227748691099476,0.757894736842105,0.0237179487179487,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.147,0.225,"6:4","147/150","I:V:L:E:Y:H:F:D:W:S:A:T",-8.98740878149641,0.940032862253634,119.468044435493,-0.0752285585987741,NA,4692673.51081231,0.384555509373631,1,0,0,188.544222231268,0.999999999999997,"lineage4","other_mutations_pyrazinamide","ASN",0,"ERR190405","ERR190405","lineage4.3.4.1","mw","Malawi","pnca_p.asp129asn","A","E","ASP","DA129","pnca_complex.pdb"
|
|
"D129N","L4","PZA","D","D129",129,"N",0,"Sensitive","OM","hydrophilic","hydrophilic","acidic","neutral","neg","polar",14.781,-3.245,-0.735,1.83782,-2.127,-0.87,72,85,0.074,5,5,0,0,"strand",1.63333333333333,7.77,7.18700589334483e-05,2.42412778478352,0.0001249735077034,0,1.03410070803344e-29,-2,38,0,4,34,0,0,0,0,-2,0,-2,0,0,0,0,0,0,0,-1,0,0,0,2,0,-0.82193515704154,-0.189922480620155,0.0669374048470633,-0.362659846547315,-0.227748691099476,0.757894736842105,0.0237179487179487,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.147,0.225,"6:4","147/150","I:V:L:E:Y:H:F:D:W:S:A:T",-8.98740878149641,0.940032862253634,119.468044435493,-0.0752285585987741,NA,4692673.51081231,0.384555509373631,1,0,0,188.544222231268,0.999999999999997,"lineage4","other_mutations_pyrazinamide","ASN",0,"SAMN03648177,SRR2100930","SRR2100930","lineage4.3.4.1","","","pnca_p.asp129asn","A","E","ASP","DA129","pnca_complex.pdb"
|
|
"D129Y","L2","PZA","D","D129",129,"Y",NA,"Pre-MDR","OM","hydrophilic","hydrophobic","acidic","neutral","neg","polar",14.781,-2.832,0.187,3.80937,0.436,0.12,42,71,0.074,5,5,0,0,"strand",1.63333333333333,7.77,7.18700589334483e-05,9.70142977291842,188179.926264589,Inf,0.763784339928386,-40,34,0,4,30,0,0,0,0,4,0,0,2,0,0,0,0,-8,0,-3,-5,8,0,4,2,-0.717325227963526,0.159013605442177,0.138745547388894,0.368243243243243,0.0674157303370786,0.442105263157895,0.0237179487179487,"Destabilising","Stabilising","Destabilising","Stabilising","Stabilising","effect",-0.147,0.225,"6:4","147/150","I:V:L:E:Y:H:F:D:W:S:A:T",12.1451538387262,0.919026337424226,119.468044436217,0.101660271548266,5.0115366606409e-06,NA,0.986835744238421,0.170978870202674,0.767057556984365,0.124324963210678,Inf,0.382146811758261,"lineage2","other_mutations_pyrazinamide","TYR",0,"SRR5074094","SRR5074094","lineage2.2.1.1","vn","Vietnam","pnca_p.asp129tyr","A","E","ASP","DA129","pnca_complex.pdb"
|
|
"D129Y","L4","PZA","D","D129",129,"Y",1,"Pre-MDR","OM","hydrophilic","hydrophobic","acidic","neutral","neg","polar",14.781,-2.832,0.187,3.80937,0.436,0.12,42,71,0.074,5,5,0,0,"strand",1.63333333333333,7.77,7.18700589334483e-05,9.70142977291842,188179.926264589,Inf,0.763784339928386,-40,34,0,4,30,0,0,0,0,4,0,0,2,0,0,0,0,-8,0,-3,-5,8,0,4,2,-0.717325227963526,0.159013605442177,0.138745547388894,0.368243243243243,0.0674157303370786,0.442105263157895,0.0237179487179487,"Destabilising","Stabilising","Destabilising","Stabilising","Stabilising","effect",-0.147,0.225,"6:4","147/150","I:V:L:E:Y:H:F:D:W:S:A:T",12.1451538387262,0.919026337424226,119.468044436217,0.101660271548266,5.0115366606409e-06,NA,0.986835744238421,0.170978870202674,0.767057556984365,0.124324963210678,Inf,0.382146811758261,"lineage4","other_mutations_pyrazinamide","TYR",0,"0728S-sc-2011-10-12T14:58:56Z-1289122,ERR108457","ERR108457","lineage4.8","ru","Russia,unknown","pnca_p.asp129tyr","A","E","ASP","DA129","pnca_complex.pdb"
|
|
"V130A","L2","PZA","V","V130",130,"A",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",10.402,-1.377,-2.827,3.70939,-2.959,-2.32,51,75,0.064,5,5,0,0,"strand",1.63333333333333,11.27,7.18700589334483e-05,2.42412778478352,0.0001249735077034,0,1.03410070803344e-29,2,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,3,0,3,0,4,0,4,3,-0.348784194528875,-0.730490956072351,0.135104058158932,-0.504518329070759,-0.607329842931937,0.536842105263158,0.0205128205128205,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.147,0.225,"6:4","147/150","M:F:D:C:I:L:V",-8.98740878149641,0.940032862253633,119.468044435491,-0.0752285585987751,NA,4692673.51081327,0.384555509373631,1,0,0,188.544222231268,0.999999999999997,"lineage2","dr_mutations_pyrazinamide","ALA",0,"ERR029210","ERR029210","lineage2.2.1","nl","Netherlands","pnca_p.val130ala","A","E","VAL","VA130","pnca_complex.pdb"
|
|
"V130A","L4","PZA","V","V130",130,"A",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",10.402,-1.377,-2.827,3.70939,-2.959,-2.32,51,75,0.064,5,5,0,0,"strand",1.63333333333333,11.27,7.18700589334483e-05,2.42412778478352,0.0001249735077034,0,1.03410070803344e-29,2,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,3,0,3,0,4,0,4,3,-0.348784194528875,-0.730490956072351,0.135104058158932,-0.504518329070759,-0.607329842931937,0.536842105263158,0.0205128205128205,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.147,0.225,"6:4","147/150","M:F:D:C:I:L:V",-8.98740878149641,0.940032862253633,119.468044435491,-0.0752285585987751,NA,4692673.51081327,0.384555509373631,1,0,0,188.544222231268,0.999999999999997,"lineage4","dr_mutations_pyrazinamide","ALA",0,"SAMN02231173","SRR998798_SRR998797_SRR998796_SRR998799","lineage4.1","ml","Mali","pnca_p.val130ala","A","E","VAL","VA130","pnca_complex.pdb"
|
|
"V130A","L2","PZA","V","V130",130,"A",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",10.402,-1.377,-2.827,3.70939,-2.959,-2.32,51,75,0.064,5,5,0,0,"strand",1.63333333333333,11.27,7.18700589334483e-05,2.42412778478352,0.0001249735077034,0,1.03410070803344e-29,2,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,3,0,3,0,4,0,4,3,-0.348784194528875,-0.730490956072351,0.135104058158932,-0.504518329070759,-0.607329842931937,0.536842105263158,0.0205128205128205,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.147,0.225,"6:4","147/150","M:F:D:C:I:L:V",-8.98740878149641,0.940032862253633,119.468044435491,-0.0752285585987751,NA,4692673.51081327,0.384555509373631,1,0,0,188.544222231268,0.999999999999997,"lineage2","dr_mutations_pyrazinamide","ALA",0,"SAMN02398710","SRR1144759_SRR1047996","lineage2.2.2","kr","South Korea","pnca_p.val130ala","A","E","VAL","VA130","pnca_complex.pdb"
|
|
"V130A","L2","PZA","V","V130",130,"A",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",10.402,-1.377,-2.827,3.70939,-2.959,-2.32,51,75,0.064,5,5,0,0,"strand",1.63333333333333,11.27,7.18700589334483e-05,2.42412778478352,0.0001249735077034,0,1.03410070803344e-29,2,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,3,0,3,0,4,0,4,3,-0.348784194528875,-0.730490956072351,0.135104058158932,-0.504518329070759,-0.607329842931937,0.536842105263158,0.0205128205128205,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.147,0.225,"6:4","147/150","M:F:D:C:I:L:V",-8.98740878149641,0.940032862253633,119.468044435491,-0.0752285585987751,NA,4692673.51081327,0.384555509373631,1,0,0,188.544222231268,0.999999999999997,"lineage2","dr_mutations_pyrazinamide","ALA",0,"SAMN02350439","SRR1062853_SRR1011482","lineage2.2.1","za","South Africa","pnca_p.val130ala","A","E","VAL","VA130","pnca_complex.pdb"
|
|
"V130A","L2","PZA","V","V130",130,"A",0,"MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",10.402,-1.377,-2.827,3.70939,-2.959,-2.32,51,75,0.064,5,5,0,0,"strand",1.63333333333333,11.27,7.18700589334483e-05,2.42412778478352,0.0001249735077034,0,1.03410070803344e-29,2,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,3,0,3,0,4,0,4,3,-0.348784194528875,-0.730490956072351,0.135104058158932,-0.504518329070759,-0.607329842931937,0.536842105263158,0.0205128205128205,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.147,0.225,"6:4","147/150","M:F:D:C:I:L:V",-8.98740878149641,0.940032862253633,119.468044435491,-0.0752285585987751,NA,4692673.51081327,0.384555509373631,1,0,0,188.544222231268,0.999999999999997,"lineage2","dr_mutations_pyrazinamide","ALA",0,"MDR_19128","SRR6824521","lineage2.2.1","cn","China: Zengcheng City, Guangzhou City, Guangdong Province","pnca_p.val130ala","A","E","VAL","VA130","pnca_complex.pdb"
|
|
"V130A","L2","PZA","V","V130",130,"A",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",10.402,-1.377,-2.827,3.70939,-2.959,-2.32,51,75,0.064,5,5,0,0,"strand",1.63333333333333,11.27,7.18700589334483e-05,2.42412778478352,0.0001249735077034,0,1.03410070803344e-29,2,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,3,0,3,0,4,0,4,3,-0.348784194528875,-0.730490956072351,0.135104058158932,-0.504518329070759,-0.607329842931937,0.536842105263158,0.0205128205128205,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.147,0.225,"6:4","147/150","M:F:D:C:I:L:V",-8.98740878149641,0.940032862253633,119.468044435491,-0.0752285585987751,NA,4692673.51081327,0.384555509373631,1,0,0,188.544222231268,0.999999999999997,"lineage2","dr_mutations_pyrazinamide","ALA",0,"SRS797343","SRR1723877","lineage2.2.1","cn","China:Guangdong","pnca_p.val130ala","A","E","VAL","VA130","pnca_complex.pdb"
|
|
"V130A","L1","PZA","V","V130",130,"A",NA,"Pre-MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",10.402,-1.377,-2.827,3.70939,-2.959,-2.32,51,75,0.064,5,5,0,0,"strand",1.63333333333333,11.27,7.18700589334483e-05,2.42412778478352,0.0001249735077034,0,1.03410070803344e-29,2,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,3,0,3,0,4,0,4,3,-0.348784194528875,-0.730490956072351,0.135104058158932,-0.504518329070759,-0.607329842931937,0.536842105263158,0.0205128205128205,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.147,0.225,"6:4","147/150","M:F:D:C:I:L:V",-8.98740878149641,0.940032862253633,119.468044435491,-0.0752285585987751,NA,4692673.51081327,0.384555509373631,1,0,0,188.544222231268,0.999999999999997,"lineage1","dr_mutations_pyrazinamide","ALA",0,"SRR5065415","SRR5065415","lineage1.1.1.1","vn","Vietnam","pnca_p.val130ala","A","E","VAL","VA130","pnca_complex.pdb"
|
|
"V130A","L2","PZA","V","V130",130,"A",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",10.402,-1.377,-2.827,3.70939,-2.959,-2.32,51,75,0.064,5,5,0,0,"strand",1.63333333333333,11.27,7.18700589334483e-05,2.42412778478352,0.0001249735077034,0,1.03410070803344e-29,2,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,3,0,3,0,4,0,4,3,-0.348784194528875,-0.730490956072351,0.135104058158932,-0.504518329070759,-0.607329842931937,0.536842105263158,0.0205128205128205,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.147,0.225,"6:4","147/150","M:F:D:C:I:L:V",-8.98740878149641,0.940032862253633,119.468044435491,-0.0752285585987751,NA,4692673.51081327,0.384555509373631,1,0,0,188.544222231268,0.999999999999997,"lineage2","dr_mutations_pyrazinamide","ALA",0,"ERR2516516","ERR2516516","lineage2.2.1","nl","Netherlands","pnca_p.val130ala","A","E","VAL","VA130","pnca_complex.pdb"
|
|
"V130A","L2","PZA","V","V130",130,"A",NA,"XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",10.402,-1.377,-2.827,3.70939,-2.959,-2.32,51,75,0.064,5,5,0,0,"strand",1.63333333333333,11.27,7.18700589334483e-05,2.42412778478352,0.0001249735077034,0,1.03410070803344e-29,2,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,3,0,3,0,4,0,4,3,-0.348784194528875,-0.730490956072351,0.135104058158932,-0.504518329070759,-0.607329842931937,0.536842105263158,0.0205128205128205,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.147,0.225,"6:4","147/150","M:F:D:C:I:L:V",-8.98740878149641,0.940032862253633,119.468044435491,-0.0752285585987751,NA,4692673.51081327,0.384555509373631,1,0,0,188.544222231268,0.999999999999997,"lineage2","dr_mutations_pyrazinamide","ALA",0,"ERR2515660","ERR2515660","lineage2.2.1","za","South Africa","pnca_p.val130ala","A","E","VAL","VA130","pnca_complex.pdb"
|
|
"V130A","L2","PZA","V","V130",130,"A",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",10.402,-1.377,-2.827,3.70939,-2.959,-2.32,51,75,0.064,5,5,0,0,"strand",1.63333333333333,11.27,7.18700589334483e-05,2.42412778478352,0.0001249735077034,0,1.03410070803344e-29,2,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,3,0,3,0,4,0,4,3,-0.348784194528875,-0.730490956072351,0.135104058158932,-0.504518329070759,-0.607329842931937,0.536842105263158,0.0205128205128205,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.147,0.225,"6:4","147/150","M:F:D:C:I:L:V",-8.98740878149641,0.940032862253633,119.468044435491,-0.0752285585987751,NA,4692673.51081327,0.384555509373631,1,0,0,188.544222231268,0.999999999999997,"lineage2","dr_mutations_pyrazinamide","ALA",0,"SAMN02403527","SRR1165257_SRR1167302_SRR1173327_SRR1173494","lineage2.2.1","za","South Africa","pnca_p.val130ala","A","E","VAL","VA130","pnca_complex.pdb"
|
|
"V130A","L2","PZA","V","V130",130,"A",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",10.402,-1.377,-2.827,3.70939,-2.959,-2.32,51,75,0.064,5,5,0,0,"strand",1.63333333333333,11.27,7.18700589334483e-05,2.42412778478352,0.0001249735077034,0,1.03410070803344e-29,2,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,3,0,3,0,4,0,4,3,-0.348784194528875,-0.730490956072351,0.135104058158932,-0.504518329070759,-0.607329842931937,0.536842105263158,0.0205128205128205,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.147,0.225,"6:4","147/150","M:F:D:C:I:L:V",-8.98740878149641,0.940032862253633,119.468044435491,-0.0752285585987751,NA,4692673.51081327,0.384555509373631,1,0,0,188.544222231268,0.999999999999997,"lineage2","dr_mutations_pyrazinamide","ALA",0,"SAMN03653230,SRS935960","SRR2024925","lineage2.2.1","cn","China","pnca_p.val130ala","A","E","VAL","VA130","pnca_complex.pdb"
|
|
"V130A","L2","PZA","V","V130",130,"A",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",10.402,-1.377,-2.827,3.70939,-2.959,-2.32,51,75,0.064,5,5,0,0,"strand",1.63333333333333,11.27,7.18700589334483e-05,2.42412778478352,0.0001249735077034,0,1.03410070803344e-29,2,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,3,0,3,0,4,0,4,3,-0.348784194528875,-0.730490956072351,0.135104058158932,-0.504518329070759,-0.607329842931937,0.536842105263158,0.0205128205128205,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.147,0.225,"6:4","147/150","M:F:D:C:I:L:V",-8.98740878149641,0.940032862253633,119.468044435491,-0.0752285585987751,NA,4692673.51081327,0.384555509373631,1,0,0,188.544222231268,0.999999999999997,"lineage2","dr_mutations_pyrazinamide","ALA",0,"SAMN02350436","SRR1062849_SRR1011478","lineage2.2.1","za","South Africa","pnca_p.val130ala","A","E","VAL","VA130","pnca_complex.pdb"
|
|
"V130A","L4","PZA","V","V130",130,"A",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",10.402,-1.377,-2.827,3.70939,-2.959,-2.32,51,75,0.064,5,5,0,0,"strand",1.63333333333333,11.27,7.18700589334483e-05,2.42412778478352,0.0001249735077034,0,1.03410070803344e-29,2,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,3,0,3,0,4,0,4,3,-0.348784194528875,-0.730490956072351,0.135104058158932,-0.504518329070759,-0.607329842931937,0.536842105263158,0.0205128205128205,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.147,0.225,"6:4","147/150","M:F:D:C:I:L:V",-8.98740878149641,0.940032862253633,119.468044435491,-0.0752285585987751,NA,4692673.51081327,0.384555509373631,1,0,0,188.544222231268,0.999999999999997,"lineage4","dr_mutations_pyrazinamide","ALA",0,"ERR1035070","ERR1035070","lineage4.4.1.1;lineage4.3.2.1","za","South Africa","pnca_p.val130ala","A","E","VAL","VA130","pnca_complex.pdb"
|
|
"V130A","L2","PZA","V","V130",130,"A",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",10.402,-1.377,-2.827,3.70939,-2.959,-2.32,51,75,0.064,5,5,0,0,"strand",1.63333333333333,11.27,7.18700589334483e-05,2.42412778478352,0.0001249735077034,0,1.03410070803344e-29,2,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,3,0,3,0,4,0,4,3,-0.348784194528875,-0.730490956072351,0.135104058158932,-0.504518329070759,-0.607329842931937,0.536842105263158,0.0205128205128205,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.147,0.225,"6:4","147/150","M:F:D:C:I:L:V",-8.98740878149641,0.940032862253633,119.468044435491,-0.0752285585987751,NA,4692673.51081327,0.384555509373631,1,0,0,188.544222231268,0.999999999999997,"lineage2","dr_mutations_pyrazinamide","ALA",0,"SAMN02403526","SRR1165255_SRR1173600_SRR1173723_SRR1167301","lineage2.2.1","za","South Africa","pnca_p.val130ala","A","E","VAL","VA130","pnca_complex.pdb"
|
|
"V130E","L2","PZA","V","V130",130,"E",1,"MDR","DM","hydrophobic","hydrophilic","non-polar","acidic","non-polar","neg",10.402,-0.292,-3.207,5.05456,-5.67,-1.74,75,85,0.064,5,5,0,0,"strand",1.63333333333333,11.27,0.0001437401178668,19.411022297013,511754.46355254,Inf,4.73122070382274,-46,-56,0,-4,-52,0,0,0,0,0,0,0,0,0,0,0,0,-5,0,0,-5,-2,0,2,-4,-0.0739614994934143,-0.828682170542636,0.184098077637512,-0.966751918158568,-0.455497382198953,0.789473684210526,0.0205128205128205,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.147,0.225,"6:4","147/150","M:F:D:C:I:L:V",13.1456002256204,0.924803768446994,139.277183326557,0.0943844491369309,0.0001628371344454,NA,1.28804840845689,0.0292235860951597,1.53426649183163,0.91081598550184,Inf,0.0296198560706035,"lineage2","dr_mutations_pyrazinamide","GLU",0,"ETB0035","SRR6257089","lineage2.2.1","ru","Russia:Leningrad Region","pnca_p.val130glu","A","E","VAL","VA130","pnca_complex.pdb"
|
|
"V130E","L2","PZA","V","V130",130,"E",1,"Pre-XDR","DM","hydrophobic","hydrophilic","non-polar","acidic","non-polar","neg",10.402,-0.292,-3.207,5.05456,-5.67,-1.74,75,85,0.064,5,5,0,0,"strand",1.63333333333333,11.27,0.0001437401178668,19.411022297013,511754.46355254,Inf,4.73122070382274,-46,-56,0,-4,-52,0,0,0,0,0,0,0,0,0,0,0,0,-5,0,0,-5,-2,0,2,-4,-0.0739614994934143,-0.828682170542636,0.184098077637512,-0.966751918158568,-0.455497382198953,0.789473684210526,0.0205128205128205,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.147,0.225,"6:4","147/150","M:F:D:C:I:L:V",13.1456002256204,0.924803768446994,139.277183326557,0.0943844491369309,0.0001628371344454,NA,1.28804840845689,0.0292235860951597,1.53426649183163,0.91081598550184,Inf,0.0296198560706035,"lineage2","dr_mutations_pyrazinamide","GLU",0,"ERR2516138","ERR2516138","lineage2.2.1","es","Spain","pnca_p.val130glu","A","E","VAL","VA130","pnca_complex.pdb"
|
|
"V130G","L2","PZA","V","V130",130,"G",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",10.402,-1.126,-3.429,5.77612,-4.805,-3.46,73,85,0.064,5,5,0,0,"strand",1.63333333333333,11.27,0.0001437401178668,19.411022297013,511754.463552424,Inf,4.73122070382274,20,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,3,0,3,0,8,0,9,23,-0.285207700101317,-0.886046511627907,0.210378863482397,-0.81926683716965,-0.905759162303665,0.768421052631579,0.0205128205128205,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.147,0.225,"6:4","147/150","M:F:D:C:I:L:V",13.1456002256202,0.924803768446987,139.277183326542,0.0943844491369394,0.0001628371344458,NA,1.28804840845689,0.0292235860951597,1.53426649183163,0.91081598550184,Inf,0.0296198560706035,"lineage2","dr_mutations_pyrazinamide","GLY",0,"SRR6397471","SRR6397471","lineage2.2.1","ca","Canada","pnca_p.val130gly","A","E","VAL","VA130","pnca_complex.pdb"
|
|
"V130G","L2","PZA","V","V130",130,"G",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",10.402,-1.126,-3.429,5.77612,-4.805,-3.46,73,85,0.064,5,5,0,0,"strand",1.63333333333333,11.27,0.0001437401178668,19.411022297013,511754.463552424,Inf,4.73122070382274,20,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,3,0,3,0,8,0,9,23,-0.285207700101317,-0.886046511627907,0.210378863482397,-0.81926683716965,-0.905759162303665,0.768421052631579,0.0205128205128205,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.147,0.225,"6:4","147/150","M:F:D:C:I:L:V",13.1456002256202,0.924803768446987,139.277183326542,0.0943844491369394,0.0001628371344458,NA,1.28804840845689,0.0292235860951597,1.53426649183163,0.91081598550184,Inf,0.0296198560706035,"lineage2","dr_mutations_pyrazinamide","GLY",0,"SRR6397784","SRR6397784","lineage2.2.1","ca","Canada","pnca_p.val130gly","A","E","VAL","VA130","pnca_complex.pdb"
|
|
"V130G","L2","PZA","V","V130",130,"G",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",10.402,-1.126,-3.429,5.77612,-4.805,-3.46,73,85,0.064,5,5,0,0,"strand",1.63333333333333,11.27,0.0001437401178668,19.411022297013,511754.463552424,Inf,4.73122070382274,20,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,3,0,3,0,8,0,9,23,-0.285207700101317,-0.886046511627907,0.210378863482397,-0.81926683716965,-0.905759162303665,0.768421052631579,0.0205128205128205,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.147,0.225,"6:4","147/150","M:F:D:C:I:L:V",13.1456002256202,0.924803768446987,139.277183326542,0.0943844491369394,0.0001628371344458,NA,1.28804840845689,0.0292235860951597,1.53426649183163,0.91081598550184,Inf,0.0296198560706035,"lineage2","dr_mutations_pyrazinamide","GLY",0,"SRR6397708","SRR6397708","lineage2.2.1","ca","Canada","pnca_p.val130gly","A","E","VAL","VA130","pnca_complex.pdb"
|
|
"V130G","L1","PZA","V","V130",130,"G",1,"Pre-MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",10.402,-1.126,-3.429,5.77612,-4.805,-3.46,73,85,0.064,5,5,0,0,"strand",1.63333333333333,11.27,0.0001437401178668,19.411022297013,511754.463552424,Inf,4.73122070382274,20,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,3,0,3,0,8,0,9,23,-0.285207700101317,-0.886046511627907,0.210378863482397,-0.81926683716965,-0.905759162303665,0.768421052631579,0.0205128205128205,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.147,0.225,"6:4","147/150","M:F:D:C:I:L:V",13.1456002256202,0.924803768446987,139.277183326542,0.0943844491369394,0.0001628371344458,NA,1.28804840845689,0.0292235860951597,1.53426649183163,0.91081598550184,Inf,0.0296198560706035,"lineage1","dr_mutations_pyrazinamide","GLY",0,"ERR2510366","ERR2510366","lineage1.1.2","pk","Pakistan","pnca_p.val130gly","A","E","VAL","VA130","pnca_complex.pdb"
|
|
"V130G","L2","PZA","V","V130",130,"G",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",10.402,-1.126,-3.429,5.77612,-4.805,-3.46,73,85,0.064,5,5,0,0,"strand",1.63333333333333,11.27,0.0001437401178668,19.411022297013,511754.463552424,Inf,4.73122070382274,20,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,3,0,3,0,8,0,9,23,-0.285207700101317,-0.886046511627907,0.210378863482397,-0.81926683716965,-0.905759162303665,0.768421052631579,0.0205128205128205,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.147,0.225,"6:4","147/150","M:F:D:C:I:L:V",13.1456002256202,0.924803768446987,139.277183326542,0.0943844491369394,0.0001628371344458,NA,1.28804840845689,0.0292235860951597,1.53426649183163,0.91081598550184,Inf,0.0296198560706035,"lineage2","dr_mutations_pyrazinamide","GLY",0,"SRR6397730","SRR6397730","lineage2.2.1","ca","Canada","pnca_p.val130gly","A","E","VAL","VA130","pnca_complex.pdb"
|
|
"V130G","L4","PZA","V","V130",130,"G",1,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",10.402,-1.126,-3.429,5.77612,-4.805,-3.46,73,85,0.064,5,5,0,0,"strand",1.63333333333333,11.27,0.0001437401178668,19.411022297013,511754.463552424,Inf,4.73122070382274,20,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,3,0,3,0,8,0,9,23,-0.285207700101317,-0.886046511627907,0.210378863482397,-0.81926683716965,-0.905759162303665,0.768421052631579,0.0205128205128205,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.147,0.225,"6:4","147/150","M:F:D:C:I:L:V",13.1456002256202,0.924803768446987,139.277183326542,0.0943844491369394,0.0001628371344458,NA,1.28804840845689,0.0292235860951597,1.53426649183163,0.91081598550184,Inf,0.0296198560706035,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERS2592792","ERR2677447","lineage4.2.2","de","Germany","pnca_p.val130gly","A","E","VAL","VA130","pnca_complex.pdb"
|
|
"V130G","L4","PZA","V","V130",130,"G",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",10.402,-1.126,-3.429,5.77612,-4.805,-3.46,73,85,0.064,5,5,0,0,"strand",1.63333333333333,11.27,0.0001437401178668,19.411022297013,511754.463552424,Inf,4.73122070382274,20,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,3,0,3,0,8,0,9,23,-0.285207700101317,-0.886046511627907,0.210378863482397,-0.81926683716965,-0.905759162303665,0.768421052631579,0.0205128205128205,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.147,0.225,"6:4","147/150","M:F:D:C:I:L:V",13.1456002256202,0.924803768446987,139.277183326542,0.0943844491369394,0.0001628371344458,NA,1.28804840845689,0.0292235860951597,1.53426649183163,0.91081598550184,Inf,0.0296198560706035,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR1023410","ERR1023410","lineage4.2.2","","","pnca_p.val130gly","A","E","VAL","VA130","pnca_complex.pdb"
|
|
"V130M","L1","PZA","V","V130",130,"M",NA,"MDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",10.402,-2.265,-1.539,-0.707302,-2.385,-1.31,34,66,0.064,5,5,0,0,"strand",1.63333333333333,11.27,7.18700589334483e-05,2.42412778478352,0.0001249735077034,0,1.03410070803344e-29,-58,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,-2,0,3,-5,-4,0,2,-6,-0.57370820668693,-0.397674418604651,-0.135988233484581,-0.406649616368286,-0.342931937172775,0.357894736842105,0.0205128205128205,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.147,0.225,"6:4","147/150","M:F:D:C:I:L:V",-8.98740878149642,0.940032862253634,119.468044435493,-0.0752285585987741,NA,4692673.5108132,0.384555509373631,1,0,0,188.544222231268,0.999999999999997,"lineage1","other_mutations_pyrazinamide","MET",0,"ERR3256144","ERR3256144","lineage1.2.1","ph","Philippines","pnca_p.val130met","A","E","VAL","VA130","pnca_complex.pdb"
|
|
"V130M","L2","PZA","V","V130",130,"M",0,"MDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",10.402,-2.265,-1.539,-0.707302,-2.385,-1.31,34,66,0.064,5,5,0,0,"strand",1.63333333333333,11.27,7.18700589334483e-05,2.42412778478352,0.0001249735077034,0,1.03410070803344e-29,-58,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,-2,0,3,-5,-4,0,2,-6,-0.57370820668693,-0.397674418604651,-0.135988233484581,-0.406649616368286,-0.342931937172775,0.357894736842105,0.0205128205128205,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.147,0.225,"6:4","147/150","M:F:D:C:I:L:V",-8.98740878149642,0.940032862253634,119.468044435493,-0.0752285585987741,NA,4692673.5108132,0.384555509373631,1,0,0,188.544222231268,0.999999999999997,"lineage2","other_mutations_pyrazinamide","MET",0,"MDR_19361","SRR6824404","lineage2.2.1","cn","China: Luoding City, Yunfu City, Guangdong Province","pnca_p.val130met","A","E","VAL","VA130","pnca_complex.pdb"
|
|
"V130M","L1","PZA","V","V130",130,"M",NA,"MDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",10.402,-2.265,-1.539,-0.707302,-2.385,-1.31,34,66,0.064,5,5,0,0,"strand",1.63333333333333,11.27,7.18700589334483e-05,2.42412778478352,0.0001249735077034,0,1.03410070803344e-29,-58,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,-2,0,3,-5,-4,0,2,-6,-0.57370820668693,-0.397674418604651,-0.135988233484581,-0.406649616368286,-0.342931937172775,0.357894736842105,0.0205128205128205,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.147,0.225,"6:4","147/150","M:F:D:C:I:L:V",-8.98740878149642,0.940032862253634,119.468044435493,-0.0752285585987741,NA,4692673.5108132,0.384555509373631,1,0,0,188.544222231268,0.999999999999997,"lineage1","other_mutations_pyrazinamide","MET",0,"ERR3256143","ERR3256143","lineage1.2.1","ph","Philippines","pnca_p.val130met","A","E","VAL","VA130","pnca_complex.pdb"
|
|
"V130M","L2","PZA","V","V130",130,"M",NA,"MDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",10.402,-2.265,-1.539,-0.707302,-2.385,-1.31,34,66,0.064,5,5,0,0,"strand",1.63333333333333,11.27,7.18700589334483e-05,2.42412778478352,0.0001249735077034,0,1.03410070803344e-29,-58,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,-2,0,3,-5,-4,0,2,-6,-0.57370820668693,-0.397674418604651,-0.135988233484581,-0.406649616368286,-0.342931937172775,0.357894736842105,0.0205128205128205,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.147,0.225,"6:4","147/150","M:F:D:C:I:L:V",-8.98740878149642,0.940032862253634,119.468044435493,-0.0752285585987741,NA,4692673.5108132,0.384555509373631,1,0,0,188.544222231268,0.999999999999997,"lineage2","other_mutations_pyrazinamide","MET",0,"SRS797070","SRR1723573_SRR1723574","lineage2.2.1","cn","China:Guangdong","pnca_p.val130met","A","E","VAL","VA130","pnca_complex.pdb"
|
|
"V131F","L2","PZA","V","V131",131,"F",1,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.063,-2.323,-1.59,1.54666,-1.786,-1.52,72,85,0.204,4,4,1,0.0057471264367816,"strand",2.66666666666667,10.36,0.0001437401178668,19.411022297013,511754.463553315,Inf,4.73122070382274,-44,-4,0,0,-4,0,0,0,0,0,0,0,0,0,0,0,0,-15,0,-7,-8,-6,0,-8,-8,-0.588399189463019,-0.410852713178295,0.0563327238689093,-0.304518329070759,-0.397905759162304,0.757894736842105,0.0653846153846154,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","147/150","D:M:S:A:G:T:C:V:L",13.1456002256219,0.924803768447041,139.277183326661,0.0943844491368713,0.000162837134443,NA,1.28804840845689,0.0292235860951597,1.53426649183163,0.91081598550184,Inf,0.0296198560706035,"lineage2","dr_mutations_pyrazinamide","PHE",0,"SAMN10961371","SRR8651611","lineage2.2.1","cn","China:Wenzhou","pnca_p.val131phe","A","E","VAL","VA131","pnca_complex.pdb"
|
|
"V131F","L4","PZA","V","V131",131,"F",1,"MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",9.063,-2.323,-1.59,1.54666,-1.786,-1.52,72,85,0.204,4,4,1,0.0057471264367816,"strand",2.66666666666667,10.36,0.0001437401178668,19.411022297013,511754.463553315,Inf,4.73122070382274,-44,-4,0,0,-4,0,0,0,0,0,0,0,0,0,0,0,0,-15,0,-7,-8,-6,0,-8,-8,-0.588399189463019,-0.410852713178295,0.0563327238689093,-0.304518329070759,-0.397905759162304,0.757894736842105,0.0653846153846154,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","147/150","D:M:S:A:G:T:C:V:L",13.1456002256219,0.924803768447041,139.277183326661,0.0943844491368713,0.000162837134443,NA,1.28804840845689,0.0292235860951597,1.53426649183163,0.91081598550184,Inf,0.0296198560706035,"lineage4","dr_mutations_pyrazinamide","PHE",0,"ERR038742","ERR038742","lineage4.8","ug","Uganda","pnca_p.val131phe","A","E","VAL","VA131","pnca_complex.pdb"
|
|
"V131G","L4","PZA","V","V131",131,"G",NA,"MDR","OM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",9.063,-1.774,-3.182,5.35345,-3.989,-2.53,54,75,0.204,4,4,1,0.0057471264367816,"strand",2.66666666666667,10.36,0.0001437401178668,19.411022297013,511754.463553338,Inf,4.73122070382274,6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,2,0,3,19,-0.449341438703141,-0.822222222222222,0.194984302041827,-0.680136402387042,-0.662303664921466,0.568421052631579,0.0653846153846154,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","147/150","D:M:S:A:G:T:C:V:L",13.145600225622,0.924803768447044,139.277183326667,0.0943844491368676,0.0001628371344429,NA,1.28804840845689,0.0292235860951597,1.53426649183163,0.91081598550184,Inf,0.0296198560706035,"lineage4","other_mutations_pyrazinamide","GLY",0,"ERR2510219","ERR2510219","lineage4.1.2.1","pe","Peru","pnca_p.val131gly","A","E","VAL","VA131","pnca_complex.pdb"
|
|
"V131G","L4","PZA","V","V131",131,"G",NA,"MDR","OM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",9.063,-1.774,-3.182,5.35345,-3.989,-2.53,54,75,0.204,4,4,1,0.0057471264367816,"strand",2.66666666666667,10.36,0.0001437401178668,19.411022297013,511754.463553338,Inf,4.73122070382274,6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,2,0,3,19,-0.449341438703141,-0.822222222222222,0.194984302041827,-0.680136402387042,-0.662303664921466,0.568421052631579,0.0653846153846154,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","147/150","D:M:S:A:G:T:C:V:L",13.145600225622,0.924803768447044,139.277183326667,0.0943844491368676,0.0001628371344429,NA,1.28804840845689,0.0292235860951597,1.53426649183163,0.91081598550184,Inf,0.0296198560706035,"lineage4","other_mutations_pyrazinamide","GLY",0,"ERR1034733","ERR1034733","lineage4.1.2.1","pe","Peru","pnca_p.val131gly","A","E","VAL","VA131","pnca_complex.pdb"
|
|
"V131G","L4","PZA","V","V131",131,"G",1,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",9.063,-1.774,-3.182,5.35345,-3.989,-2.53,54,75,0.204,4,4,1,0.0057471264367816,"strand",2.66666666666667,10.36,0.0001437401178668,19.411022297013,511754.463553338,Inf,4.73122070382274,6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,2,0,3,19,-0.449341438703141,-0.822222222222222,0.194984302041827,-0.680136402387042,-0.662303664921466,0.568421052631579,0.0653846153846154,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","147/150","D:M:S:A:G:T:C:V:L",13.145600225622,0.924803768447044,139.277183326667,0.0943844491368676,0.0001628371344429,NA,1.28804840845689,0.0292235860951597,1.53426649183163,0.91081598550184,Inf,0.0296198560706035,"lineage4","other_mutations_pyrazinamide","GLY",0,"ERR2516618","ERR2516618","lineage4.1.2.1","pe","Peru","pnca_p.val131gly","A","E","VAL","VA131","pnca_complex.pdb"
|
|
"V131G","L2","PZA","V","V131",131,"G",NA,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",9.063,-1.774,-3.182,5.35345,-3.989,-2.53,54,75,0.204,4,4,1,0.0057471264367816,"strand",2.66666666666667,10.36,0.0001437401178668,19.411022297013,511754.463553338,Inf,4.73122070382274,6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,2,0,3,19,-0.449341438703141,-0.822222222222222,0.194984302041827,-0.680136402387042,-0.662303664921466,0.568421052631579,0.0653846153846154,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","147/150","D:M:S:A:G:T:C:V:L",13.145600225622,0.924803768447044,139.277183326667,0.0943844491368676,0.0001628371344429,NA,1.28804840845689,0.0292235860951597,1.53426649183163,0.91081598550184,Inf,0.0296198560706035,"lineage2","other_mutations_pyrazinamide","GLY",0,"ERR751650","ERR751650","lineage2.2.1","th","Thailand","pnca_p.val131gly","A","E","VAL","VA131","pnca_complex.pdb"
|
|
"V131G","L4","PZA","V","V131",131,"G",1,"XDR","OM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",9.063,-1.774,-3.182,5.35345,-3.989,-2.53,54,75,0.204,4,4,1,0.0057471264367816,"strand",2.66666666666667,10.36,0.0001437401178668,19.411022297013,511754.463553338,Inf,4.73122070382274,6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,2,0,3,19,-0.449341438703141,-0.822222222222222,0.194984302041827,-0.680136402387042,-0.662303664921466,0.568421052631579,0.0653846153846154,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","147/150","D:M:S:A:G:T:C:V:L",13.145600225622,0.924803768447044,139.277183326667,0.0943844491368676,0.0001628371344429,NA,1.28804840845689,0.0292235860951597,1.53426649183163,0.91081598550184,Inf,0.0296198560706035,"lineage4","other_mutations_pyrazinamide","GLY",0,"ERR2516673","ERR2516673","lineage4.1.2.1","pe","Peru","pnca_p.val131gly","A","E","VAL","VA131","pnca_complex.pdb"
|
|
"V131G","L4","PZA","V","V131",131,"G",NA,"MDR","OM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",9.063,-1.774,-3.182,5.35345,-3.989,-2.53,54,75,0.204,4,4,1,0.0057471264367816,"strand",2.66666666666667,10.36,0.0001437401178668,19.411022297013,511754.463553338,Inf,4.73122070382274,6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,2,0,3,19,-0.449341438703141,-0.822222222222222,0.194984302041827,-0.680136402387042,-0.662303664921466,0.568421052631579,0.0653846153846154,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","147/150","D:M:S:A:G:T:C:V:L",13.145600225622,0.924803768447044,139.277183326667,0.0943844491368676,0.0001628371344429,NA,1.28804840845689,0.0292235860951597,1.53426649183163,0.91081598550184,Inf,0.0296198560706035,"lineage4","other_mutations_pyrazinamide","GLY",0,"ERR775298","ERR775298","lineage4.1.2.1","pe","","pnca_p.val131gly","A","E","VAL","VA131","pnca_complex.pdb"
|
|
"G132A","L4","PZA","G","G132",132,"A",NA,"MDR","DM","hydrophobic","hydrophobic","neutral","non-polar","non-polar","non-polar",6.912,-1.92,-0.829,5.5504,-2.927,-0.28,80,91,-1.191,9,9,0,0,"strand",2.76666666666667,8.75,0.0005749604714675,14.5802781289507,14.5802277940117,14.5801759034061,15.0663448164144,-4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-6,0,-6,-2,0,0,-7,-18,-0.486322188449848,-0.21421188630491,0.20215764974978,-0.499062233589088,-0.0732984293193717,0.842105263157895,-0.981054365733114,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","147/150","G",2.6796663501904,0.0010245352377104,0.816050632122417,3.28370108999367,3.35697961122016,99.5538692591549,1.16376580853041,0.0005075351447614,3.29453387923245,2.60435121163486,147.676327006136,0.0001037975122989,"lineage4","dr_mutations_pyrazinamide","ALA",0,"ERR3148191","ERR3148191","lineage4.1.2.1","mx","Mexico","pnca_p.gly132ala","A","E","GLY","GA132","pnca_complex.pdb"
|
|
"G132A","L4","PZA","G","G132",132,"A",NA,"MDR","DM","hydrophobic","hydrophobic","neutral","non-polar","non-polar","non-polar",6.912,-1.92,-0.829,5.5504,-2.927,-0.28,80,91,-1.191,9,9,0,0,"strand",2.76666666666667,8.75,0.0005749604714675,14.5802781289507,14.5802277940117,14.5801759034061,15.0663448164144,-4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-6,0,-6,-2,0,0,-7,-18,-0.486322188449848,-0.21421188630491,0.20215764974978,-0.499062233589088,-0.0732984293193717,0.842105263157895,-0.981054365733114,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","147/150","G",2.6796663501904,0.0010245352377104,0.816050632122417,3.28370108999367,3.35697961122016,99.5538692591549,1.16376580853041,0.0005075351447614,3.29453387923245,2.60435121163486,147.676327006136,0.0001037975122989,"lineage4","dr_mutations_pyrazinamide","ALA",0,"SAMN02586009","SRR1196518_SRR1175040_SRR1172835_SRR1184374","lineage4.3.3","za","South Africa","pnca_p.gly132ala","A","E","GLY","GA132","pnca_complex.pdb"
|
|
"G132A","L4","PZA","G","G132",132,"A",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","neutral","non-polar","non-polar","non-polar",6.912,-1.92,-0.829,5.5504,-2.927,-0.28,80,91,-1.191,9,9,0,0,"strand",2.76666666666667,8.75,0.0005749604714675,14.5802781289507,14.5802277940117,14.5801759034061,15.0663448164144,-4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-6,0,-6,-2,0,0,-7,-18,-0.486322188449848,-0.21421188630491,0.20215764974978,-0.499062233589088,-0.0732984293193717,0.842105263157895,-0.981054365733114,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","147/150","G",2.6796663501904,0.0010245352377104,0.816050632122417,3.28370108999367,3.35697961122016,99.5538692591549,1.16376580853041,0.0005075351447614,3.29453387923245,2.60435121163486,147.676327006136,0.0001037975122989,"lineage4","dr_mutations_pyrazinamide","ALA",0,"ERR2515743","ERR2515743","lineage4.3.3","za","South Africa","pnca_p.gly132ala","A","E","GLY","GA132","pnca_complex.pdb"
|
|
"G132A","L2","PZA","G","G132",132,"A",NA,"MDR","DM","hydrophobic","hydrophobic","neutral","non-polar","non-polar","non-polar",6.912,-1.92,-0.829,5.5504,-2.927,-0.28,80,91,-1.191,9,9,0,0,"strand",2.76666666666667,8.75,0.0005749604714675,14.5802781289507,14.5802277940117,14.5801759034061,15.0663448164144,-4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-6,0,-6,-2,0,0,-7,-18,-0.486322188449848,-0.21421188630491,0.20215764974978,-0.499062233589088,-0.0732984293193717,0.842105263157895,-0.981054365733114,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","147/150","G",2.6796663501904,0.0010245352377104,0.816050632122417,3.28370108999367,3.35697961122016,99.5538692591549,1.16376580853041,0.0005075351447614,3.29453387923245,2.60435121163486,147.676327006136,0.0001037975122989,"lineage2","dr_mutations_pyrazinamide","ALA",0,"OU13-FMR310","SRR5341257","lineage2.2.1","in","India","pnca_p.gly132ala","A","E","GLY","GA132","pnca_complex.pdb"
|
|
"G132A","L4","PZA","G","G132",132,"A",NA,"MDR","DM","hydrophobic","hydrophobic","neutral","non-polar","non-polar","non-polar",6.912,-1.92,-0.829,5.5504,-2.927,-0.28,80,91,-1.191,9,9,0,0,"strand",2.76666666666667,8.75,0.0005749604714675,14.5802781289507,14.5802277940117,14.5801759034061,15.0663448164144,-4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-6,0,-6,-2,0,0,-7,-18,-0.486322188449848,-0.21421188630491,0.20215764974978,-0.499062233589088,-0.0732984293193717,0.842105263157895,-0.981054365733114,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","147/150","G",2.6796663501904,0.0010245352377104,0.816050632122417,3.28370108999367,3.35697961122016,99.5538692591549,1.16376580853041,0.0005075351447614,3.29453387923245,2.60435121163486,147.676327006136,0.0001037975122989,"lineage4","dr_mutations_pyrazinamide","ALA",0,"SAMN02586034","SRR1196547_SRR1172889_SRR1184305_SRR1173072","lineage4.3.3","za","South Africa","pnca_p.gly132ala","A","E","GLY","GA132","pnca_complex.pdb"
|
|
"G132A","L4","PZA","G","G132",132,"A",NA,"MDR","DM","hydrophobic","hydrophobic","neutral","non-polar","non-polar","non-polar",6.912,-1.92,-0.829,5.5504,-2.927,-0.28,80,91,-1.191,9,9,0,0,"strand",2.76666666666667,8.75,0.0005749604714675,14.5802781289507,14.5802277940117,14.5801759034061,15.0663448164144,-4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-6,0,-6,-2,0,0,-7,-18,-0.486322188449848,-0.21421188630491,0.20215764974978,-0.499062233589088,-0.0732984293193717,0.842105263157895,-0.981054365733114,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","147/150","G",2.6796663501904,0.0010245352377104,0.816050632122417,3.28370108999367,3.35697961122016,99.5538692591549,1.16376580853041,0.0005075351447614,3.29453387923245,2.60435121163486,147.676327006136,0.0001037975122989,"lineage4","dr_mutations_pyrazinamide","ALA",0,"SAMN02585997","SRR1196524_SRR1172980_SRR1184293_SRR1173080","lineage4.3.3","za","South Africa","pnca_p.gly132ala","A","E","GLY","GA132","pnca_complex.pdb"
|
|
"G132A","L4","PZA","G","G132",132,"A",1,"MDR","DM","hydrophobic","hydrophobic","neutral","non-polar","non-polar","non-polar",6.912,-1.92,-0.829,5.5504,-2.927,-0.28,80,91,-1.191,9,9,0,0,"strand",2.76666666666667,8.75,0.0005749604714675,14.5802781289507,14.5802277940117,14.5801759034061,15.0663448164144,-4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-6,0,-6,-2,0,0,-7,-18,-0.486322188449848,-0.21421188630491,0.20215764974978,-0.499062233589088,-0.0732984293193717,0.842105263157895,-0.981054365733114,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","147/150","G",2.6796663501904,0.0010245352377104,0.816050632122417,3.28370108999367,3.35697961122016,99.5538692591549,1.16376580853041,0.0005075351447614,3.29453387923245,2.60435121163486,147.676327006136,0.0001037975122989,"lineage4","dr_mutations_pyrazinamide","ALA",0,"SAMN02053804","SRR833196_SRR833100","lineage4.3.3","za","South Africa","pnca_p.gly132ala","A","E","GLY","GA132","pnca_complex.pdb"
|
|
"G132A","L2","PZA","G","G132",132,"A",0,"XDR","DM","hydrophobic","hydrophobic","neutral","non-polar","non-polar","non-polar",6.912,-1.92,-0.829,5.5504,-2.927,-0.28,80,91,-1.191,9,9,0,0,"strand",2.76666666666667,8.75,0.0005749604714675,14.5802781289507,14.5802277940117,14.5801759034061,15.0663448164144,-4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-6,0,-6,-2,0,0,-7,-18,-0.486322188449848,-0.21421188630491,0.20215764974978,-0.499062233589088,-0.0732984293193717,0.842105263157895,-0.981054365733114,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","147/150","G",2.6796663501904,0.0010245352377104,0.816050632122417,3.28370108999367,3.35697961122016,99.5538692591549,1.16376580853041,0.0005075351447614,3.29453387923245,2.60435121163486,147.676327006136,0.0001037975122989,"lineage2","dr_mutations_pyrazinamide","ALA",0,"ERR2510718","ERR2510718","lineage2.2.1","it","Italy","pnca_p.gly132ala","A","E","GLY","GA132","pnca_complex.pdb"
|
|
"G132A","L4","PZA","G","G132",132,"A",NA,"MDR","DM","hydrophobic","hydrophobic","neutral","non-polar","non-polar","non-polar",6.912,-1.92,-0.829,5.5504,-2.927,-0.28,80,91,-1.191,9,9,0,0,"strand",2.76666666666667,8.75,0.0005749604714675,14.5802781289507,14.5802277940117,14.5801759034061,15.0663448164144,-4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-6,0,-6,-2,0,0,-7,-18,-0.486322188449848,-0.21421188630491,0.20215764974978,-0.499062233589088,-0.0732984293193717,0.842105263157895,-0.981054365733114,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","147/150","G",2.6796663501904,0.0010245352377104,0.816050632122417,3.28370108999367,3.35697961122016,99.5538692591549,1.16376580853041,0.0005075351447614,3.29453387923245,2.60435121163486,147.676327006136,0.0001037975122989,"lineage4","dr_mutations_pyrazinamide","ALA",0,"SAMN02586045","SRR1173442_SRR1196671_SRR1173563_SRR1184328","lineage4.3.3","za","South Africa","pnca_p.gly132ala","A","E","GLY","GA132","pnca_complex.pdb"
|
|
"G132A","L2","PZA","G","G132",132,"A",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","neutral","non-polar","non-polar","non-polar",6.912,-1.92,-0.829,5.5504,-2.927,-0.28,80,91,-1.191,9,9,0,0,"strand",2.76666666666667,8.75,0.0005749604714675,14.5802781289507,14.5802277940117,14.5801759034061,15.0663448164144,-4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-6,0,-6,-2,0,0,-7,-18,-0.486322188449848,-0.21421188630491,0.20215764974978,-0.499062233589088,-0.0732984293193717,0.842105263157895,-0.981054365733114,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","147/150","G",2.6796663501904,0.0010245352377104,0.816050632122417,3.28370108999367,3.35697961122016,99.5538692591549,1.16376580853041,0.0005075351447614,3.29453387923245,2.60435121163486,147.676327006136,0.0001037975122989,"lineage2","dr_mutations_pyrazinamide","ALA",0,"OU36-FMRHH12","SRR5341237","lineage2.2.1","in","India","pnca_p.gly132ala","A","E","GLY","GA132","pnca_complex.pdb"
|
|
"G132A","L2","PZA","G","G132",132,"A",0,"Pre-XDR","DM","hydrophobic","hydrophobic","neutral","non-polar","non-polar","non-polar",6.912,-1.92,-0.829,5.5504,-2.927,-0.28,80,91,-1.191,9,9,0,0,"strand",2.76666666666667,8.75,0.0005749604714675,14.5802781289507,14.5802277940117,14.5801759034061,15.0663448164144,-4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-6,0,-6,-2,0,0,-7,-18,-0.486322188449848,-0.21421188630491,0.20215764974978,-0.499062233589088,-0.0732984293193717,0.842105263157895,-0.981054365733114,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","147/150","G",2.6796663501904,0.0010245352377104,0.816050632122417,3.28370108999367,3.35697961122016,99.5538692591549,1.16376580853041,0.0005075351447614,3.29453387923245,2.60435121163486,147.676327006136,0.0001037975122989,"lineage2","dr_mutations_pyrazinamide","ALA",0,"ERR2516886","ERR2516886","lineage2.2.1","gb","UK","pnca_p.gly132ala","A","E","GLY","GA132","pnca_complex.pdb"
|
|
"G132A","L4","PZA","G","G132",132,"A",NA,"MDR","DM","hydrophobic","hydrophobic","neutral","non-polar","non-polar","non-polar",6.912,-1.92,-0.829,5.5504,-2.927,-0.28,80,91,-1.191,9,9,0,0,"strand",2.76666666666667,8.75,0.0005749604714675,14.5802781289507,14.5802277940117,14.5801759034061,15.0663448164144,-4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-6,0,-6,-2,0,0,-7,-18,-0.486322188449848,-0.21421188630491,0.20215764974978,-0.499062233589088,-0.0732984293193717,0.842105263157895,-0.981054365733114,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","147/150","G",2.6796663501904,0.0010245352377104,0.816050632122417,3.28370108999367,3.35697961122016,99.5538692591549,1.16376580853041,0.0005075351447614,3.29453387923245,2.60435121163486,147.676327006136,0.0001037975122989,"lineage4","dr_mutations_pyrazinamide","ALA",0,"SAMN02584606","SRR1168962_SRR1166193","lineage4.3.3","md","Moldova","pnca_p.gly132ala","A","E","GLY","GA132","pnca_complex.pdb"
|
|
"G132A","L2","PZA","G","G132",132,"A",NA,"XDR","DM","hydrophobic","hydrophobic","neutral","non-polar","non-polar","non-polar",6.912,-1.92,-0.829,5.5504,-2.927,-0.28,80,91,-1.191,9,9,0,0,"strand",2.76666666666667,8.75,0.0005749604714675,14.5802781289507,14.5802277940117,14.5801759034061,15.0663448164144,-4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-6,0,-6,-2,0,0,-7,-18,-0.486322188449848,-0.21421188630491,0.20215764974978,-0.499062233589088,-0.0732984293193717,0.842105263157895,-0.981054365733114,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","147/150","G",2.6796663501904,0.0010245352377104,0.816050632122417,3.28370108999367,3.35697961122016,99.5538692591549,1.16376580853041,0.0005075351447614,3.29453387923245,2.60435121163486,147.676327006136,0.0001037975122989,"lineage2","dr_mutations_pyrazinamide","ALA",0,"SAMN02628487","SRR1173311","lineage2.2.1","ir","Iran","pnca_p.gly132ala","A","E","GLY","GA132","pnca_complex.pdb"
|
|
"G132A","L4","PZA","G","G132",132,"A",1,"MDR","DM","hydrophobic","hydrophobic","neutral","non-polar","non-polar","non-polar",6.912,-1.92,-0.829,5.5504,-2.927,-0.28,80,91,-1.191,9,9,0,0,"strand",2.76666666666667,8.75,0.0005749604714675,14.5802781289507,14.5802277940117,14.5801759034061,15.0663448164144,-4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-6,0,-6,-2,0,0,-7,-18,-0.486322188449848,-0.21421188630491,0.20215764974978,-0.499062233589088,-0.0732984293193717,0.842105263157895,-0.981054365733114,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","147/150","G",2.6796663501904,0.0010245352377104,0.816050632122417,3.28370108999367,3.35697961122016,99.5538692591549,1.16376580853041,0.0005075351447614,3.29453387923245,2.60435121163486,147.676327006136,0.0001037975122989,"lineage4","dr_mutations_pyrazinamide","ALA",0,"ERR2516008","ERR2516008","lineage4.3.3","za","South Africa","pnca_p.gly132ala","A","E","GLY","GA132","pnca_complex.pdb"
|
|
"G132A","L4","PZA","G","G132",132,"A",1,"XDR","DM","hydrophobic","hydrophobic","neutral","non-polar","non-polar","non-polar",6.912,-1.92,-0.829,5.5504,-2.927,-0.28,80,91,-1.191,9,9,0,0,"strand",2.76666666666667,8.75,0.0005749604714675,14.5802781289507,14.5802277940117,14.5801759034061,15.0663448164144,-4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-6,0,-6,-2,0,0,-7,-18,-0.486322188449848,-0.21421188630491,0.20215764974978,-0.499062233589088,-0.0732984293193717,0.842105263157895,-0.981054365733114,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","147/150","G",2.6796663501904,0.0010245352377104,0.816050632122417,3.28370108999367,3.35697961122016,99.5538692591549,1.16376580853041,0.0005075351447614,3.29453387923245,2.60435121163486,147.676327006136,0.0001037975122989,"lineage4","dr_mutations_pyrazinamide","ALA",0,"ERR1873534","ERR1873534","lineage4.1.2.1","za","South Africa","pnca_p.gly132ala","A","E","GLY","GA132","pnca_complex.pdb"
|
|
"G132A","L4","PZA","G","G132",132,"A",NA,"MDR","DM","hydrophobic","hydrophobic","neutral","non-polar","non-polar","non-polar",6.912,-1.92,-0.829,5.5504,-2.927,-0.28,80,91,-1.191,9,9,0,0,"strand",2.76666666666667,8.75,0.0005749604714675,14.5802781289507,14.5802277940117,14.5801759034061,15.0663448164144,-4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-6,0,-6,-2,0,0,-7,-18,-0.486322188449848,-0.21421188630491,0.20215764974978,-0.499062233589088,-0.0732984293193717,0.842105263157895,-0.981054365733114,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","147/150","G",2.6796663501904,0.0010245352377104,0.816050632122417,3.28370108999367,3.35697961122016,99.5538692591549,1.16376580853041,0.0005075351447614,3.29453387923245,2.60435121163486,147.676327006136,0.0001037975122989,"lineage4","dr_mutations_pyrazinamide","ALA",0,"SAMN02586063","SRR1196555_SRR1172916_SRR1184337_SRR1175055","lineage4.3.3","za","South Africa","pnca_p.gly132ala","A","E","GLY","GA132","pnca_complex.pdb"
|
|
"G132A","L4","PZA","G","G132",132,"A",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","neutral","non-polar","non-polar","non-polar",6.912,-1.92,-0.829,5.5504,-2.927,-0.28,80,91,-1.191,9,9,0,0,"strand",2.76666666666667,8.75,0.0005749604714675,14.5802781289507,14.5802277940117,14.5801759034061,15.0663448164144,-4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-6,0,-6,-2,0,0,-7,-18,-0.486322188449848,-0.21421188630491,0.20215764974978,-0.499062233589088,-0.0732984293193717,0.842105263157895,-0.981054365733114,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","147/150","G",2.6796663501904,0.0010245352377104,0.816050632122417,3.28370108999367,3.35697961122016,99.5538692591549,1.16376580853041,0.0005075351447614,3.29453387923245,2.60435121163486,147.676327006136,0.0001037975122989,"lineage4","dr_mutations_pyrazinamide","ALA",0,"ERR2515924","ERR2515924","lineage4.3.3","za","South Africa","pnca_p.gly132ala","A","E","GLY","GA132","pnca_complex.pdb"
|
|
"G132A","L4","PZA","G","G132",132,"A",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","neutral","non-polar","non-polar","non-polar",6.912,-1.92,-0.829,5.5504,-2.927,-0.28,80,91,-1.191,9,9,0,0,"strand",2.76666666666667,8.75,0.0005749604714675,14.5802781289507,14.5802277940117,14.5801759034061,15.0663448164144,-4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-6,0,-6,-2,0,0,-7,-18,-0.486322188449848,-0.21421188630491,0.20215764974978,-0.499062233589088,-0.0732984293193717,0.842105263157895,-0.981054365733114,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","147/150","G",2.6796663501904,0.0010245352377104,0.816050632122417,3.28370108999367,3.35697961122016,99.5538692591549,1.16376580853041,0.0005075351447614,3.29453387923245,2.60435121163486,147.676327006136,0.0001037975122989,"lineage4","dr_mutations_pyrazinamide","ALA",0,"ERR2515988","ERR2515988","lineage4.3.3","za","South Africa","pnca_p.gly132ala","A","E","GLY","GA132","pnca_complex.pdb"
|
|
"G132A","L4","PZA","G","G132",132,"A",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","neutral","non-polar","non-polar","non-polar",6.912,-1.92,-0.829,5.5504,-2.927,-0.28,80,91,-1.191,9,9,0,0,"strand",2.76666666666667,8.75,0.0005749604714675,14.5802781289507,14.5802277940117,14.5801759034061,15.0663448164144,-4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-6,0,-6,-2,0,0,-7,-18,-0.486322188449848,-0.21421188630491,0.20215764974978,-0.499062233589088,-0.0732984293193717,0.842105263157895,-0.981054365733114,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","147/150","G",2.6796663501904,0.0010245352377104,0.816050632122417,3.28370108999367,3.35697961122016,99.5538692591549,1.16376580853041,0.0005075351447614,3.29453387923245,2.60435121163486,147.676327006136,0.0001037975122989,"lineage4","dr_mutations_pyrazinamide","ALA",0,"SAMN02585964","SRR1184115_SRR1180281_SRR1181172_SRR1180422","lineage4.3.3","za","South Africa","pnca_p.gly132ala","A","E","GLY","GA132","pnca_complex.pdb"
|
|
"G132A","L4","PZA","G","G132",132,"A",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","neutral","non-polar","non-polar","non-polar",6.912,-1.92,-0.829,5.5504,-2.927,-0.28,80,91,-1.191,9,9,0,0,"strand",2.76666666666667,8.75,0.0005749604714675,14.5802781289507,14.5802277940117,14.5801759034061,15.0663448164144,-4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-6,0,-6,-2,0,0,-7,-18,-0.486322188449848,-0.21421188630491,0.20215764974978,-0.499062233589088,-0.0732984293193717,0.842105263157895,-0.981054365733114,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","147/150","G",2.6796663501904,0.0010245352377104,0.816050632122417,3.28370108999367,3.35697961122016,99.5538692591549,1.16376580853041,0.0005075351447614,3.29453387923245,2.60435121163486,147.676327006136,0.0001037975122989,"lineage4","dr_mutations_pyrazinamide","ALA",0,"SAMN02585957","SRR1180190_SRR1181352_SRR1181404_SRR1183042","lineage4.3.3","za","South Africa","pnca_p.gly132ala","A","E","GLY","GA132","pnca_complex.pdb"
|
|
"G132A","L4","PZA","G","G132",132,"A",NA,"Pre-MDR","DM","hydrophobic","hydrophobic","neutral","non-polar","non-polar","non-polar",6.912,-1.92,-0.829,5.5504,-2.927,-0.28,80,91,-1.191,9,9,0,0,"strand",2.76666666666667,8.75,0.0005749604714675,14.5802781289507,14.5802277940117,14.5801759034061,15.0663448164144,-4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-6,0,-6,-2,0,0,-7,-18,-0.486322188449848,-0.21421188630491,0.20215764974978,-0.499062233589088,-0.0732984293193717,0.842105263157895,-0.981054365733114,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","147/150","G",2.6796663501904,0.0010245352377104,0.816050632122417,3.28370108999367,3.35697961122016,99.5538692591549,1.16376580853041,0.0005075351447614,3.29453387923245,2.60435121163486,147.676327006136,0.0001037975122989,"lineage4","dr_mutations_pyrazinamide","ALA",0,"SAMN02586102","SRR1173351_SRR1173510_SRR1184335_SRR1196568","lineage4.3.3","za","South Africa","pnca_p.gly132ala","A","E","GLY","GA132","pnca_complex.pdb"
|
|
"G132A","L4","PZA","G","G132",132,"A",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","neutral","non-polar","non-polar","non-polar",6.912,-1.92,-0.829,5.5504,-2.927,-0.28,80,91,-1.191,9,9,0,0,"strand",2.76666666666667,8.75,0.0005749604714675,14.5802781289507,14.5802277940117,14.5801759034061,15.0663448164144,-4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-6,0,-6,-2,0,0,-7,-18,-0.486322188449848,-0.21421188630491,0.20215764974978,-0.499062233589088,-0.0732984293193717,0.842105263157895,-0.981054365733114,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","147/150","G",2.6796663501904,0.0010245352377104,0.816050632122417,3.28370108999367,3.35697961122016,99.5538692591549,1.16376580853041,0.0005075351447614,3.29453387923245,2.60435121163486,147.676327006136,0.0001037975122989,"lineage4","dr_mutations_pyrazinamide","ALA",0,"SAMN02585960","SRR1180328_SRR1181260_SRR1180403_SRR1181321","lineage4.3.3","za","South Africa","pnca_p.gly132ala","A","E","GLY","GA132","pnca_complex.pdb"
|
|
"G132A","L2","PZA","G","G132",132,"A",NA,"MDR","DM","hydrophobic","hydrophobic","neutral","non-polar","non-polar","non-polar",6.912,-1.92,-0.829,5.5504,-2.927,-0.28,80,91,-1.191,9,9,0,0,"strand",2.76666666666667,8.75,0.0005749604714675,14.5802781289507,14.5802277940117,14.5801759034061,15.0663448164144,-4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-6,0,-6,-2,0,0,-7,-18,-0.486322188449848,-0.21421188630491,0.20215764974978,-0.499062233589088,-0.0732984293193717,0.842105263157895,-0.981054365733114,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","147/150","G",2.6796663501904,0.0010245352377104,0.816050632122417,3.28370108999367,3.35697961122016,99.5538692591549,1.16376580853041,0.0005075351447614,3.29453387923245,2.60435121163486,147.676327006136,0.0001037975122989,"lineage2","dr_mutations_pyrazinamide","ALA",0,"ERR2516853","ERR2516853","lineage2.2.1","gb","UK","pnca_p.gly132ala","A","E","GLY","GA132","pnca_complex.pdb"
|
|
"G132A","L4","PZA","G","G132",132,"A",NA,"XDR","DM","hydrophobic","hydrophobic","neutral","non-polar","non-polar","non-polar",6.912,-1.92,-0.829,5.5504,-2.927,-0.28,80,91,-1.191,9,9,0,0,"strand",2.76666666666667,8.75,0.0005749604714675,14.5802781289507,14.5802277940117,14.5801759034061,15.0663448164144,-4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-6,0,-6,-2,0,0,-7,-18,-0.486322188449848,-0.21421188630491,0.20215764974978,-0.499062233589088,-0.0732984293193717,0.842105263157895,-0.981054365733114,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","147/150","G",2.6796663501904,0.0010245352377104,0.816050632122417,3.28370108999367,3.35697961122016,99.5538692591549,1.16376580853041,0.0005075351447614,3.29453387923245,2.60435121163486,147.676327006136,0.0001037975122989,"lineage4","dr_mutations_pyrazinamide","ALA",0,"ERR1035006","ERR1035006","lineage4.1.2.1","za","South Africa","pnca_p.gly132ala","A","E","GLY","GA132","pnca_complex.pdb"
|
|
"G132A","L4","PZA","G","G132",132,"A",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","neutral","non-polar","non-polar","non-polar",6.912,-1.92,-0.829,5.5504,-2.927,-0.28,80,91,-1.191,9,9,0,0,"strand",2.76666666666667,8.75,0.0005749604714675,14.5802781289507,14.5802277940117,14.5801759034061,15.0663448164144,-4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-6,0,-6,-2,0,0,-7,-18,-0.486322188449848,-0.21421188630491,0.20215764974978,-0.499062233589088,-0.0732984293193717,0.842105263157895,-0.981054365733114,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","147/150","G",2.6796663501904,0.0010245352377104,0.816050632122417,3.28370108999367,3.35697961122016,99.5538692591549,1.16376580853041,0.0005075351447614,3.29453387923245,2.60435121163486,147.676327006136,0.0001037975122989,"lineage4","dr_mutations_pyrazinamide","ALA",0,"SAMN02350481","SRR1140949_SRR1019143","lineage4.3.3","za","South Africa","pnca_p.gly132ala","A","E","GLY","GA132","pnca_complex.pdb"
|
|
"G132A","L4","PZA","G","G132",132,"A",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","neutral","non-polar","non-polar","non-polar",6.912,-1.92,-0.829,5.5504,-2.927,-0.28,80,91,-1.191,9,9,0,0,"strand",2.76666666666667,8.75,0.0005749604714675,14.5802781289507,14.5802277940117,14.5801759034061,15.0663448164144,-4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-6,0,-6,-2,0,0,-7,-18,-0.486322188449848,-0.21421188630491,0.20215764974978,-0.499062233589088,-0.0732984293193717,0.842105263157895,-0.981054365733114,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","147/150","G",2.6796663501904,0.0010245352377104,0.816050632122417,3.28370108999367,3.35697961122016,99.5538692591549,1.16376580853041,0.0005075351447614,3.29453387923245,2.60435121163486,147.676327006136,0.0001037975122989,"lineage4","dr_mutations_pyrazinamide","ALA",0,"SAMN02585973","SRR1181008_SRR1180157_SRR1183967_SRR1183101","lineage4.3.3","za","South Africa","pnca_p.gly132ala","A","E","GLY","GA132","pnca_complex.pdb"
|
|
"G132A","L2","PZA","G","G132",132,"A",1,"MDR","DM","hydrophobic","hydrophobic","neutral","non-polar","non-polar","non-polar",6.912,-1.92,-0.829,5.5504,-2.927,-0.28,80,91,-1.191,9,9,0,0,"strand",2.76666666666667,8.75,0.0005749604714675,14.5802781289507,14.5802277940117,14.5801759034061,15.0663448164144,-4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-6,0,-6,-2,0,0,-7,-18,-0.486322188449848,-0.21421188630491,0.20215764974978,-0.499062233589088,-0.0732984293193717,0.842105263157895,-0.981054365733114,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","147/150","G",2.6796663501904,0.0010245352377104,0.816050632122417,3.28370108999367,3.35697961122016,99.5538692591549,1.16376580853041,0.0005075351447614,3.29453387923245,2.60435121163486,147.676327006136,0.0001037975122989,"lineage2","dr_mutations_pyrazinamide","ALA",0,"ERR2516842","ERR2516842","lineage2.2.1","gb","UK","pnca_p.gly132ala","A","E","GLY","GA132","pnca_complex.pdb"
|
|
"G132A","L4","PZA","G","G132",132,"A",NA,"MDR","DM","hydrophobic","hydrophobic","neutral","non-polar","non-polar","non-polar",6.912,-1.92,-0.829,5.5504,-2.927,-0.28,80,91,-1.191,9,9,0,0,"strand",2.76666666666667,8.75,0.0005749604714675,14.5802781289507,14.5802277940117,14.5801759034061,15.0663448164144,-4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-6,0,-6,-2,0,0,-7,-18,-0.486322188449848,-0.21421188630491,0.20215764974978,-0.499062233589088,-0.0732984293193717,0.842105263157895,-0.981054365733114,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","147/150","G",2.6796663501904,0.0010245352377104,0.816050632122417,3.28370108999367,3.35697961122016,99.5538692591549,1.16376580853041,0.0005075351447614,3.29453387923245,2.60435121163486,147.676327006136,0.0001037975122989,"lineage4","dr_mutations_pyrazinamide","ALA",0,"ERR3148223","ERR3148223","lineage4.1.2.1","mx","Mexico","pnca_p.gly132ala","A","E","GLY","GA132","pnca_complex.pdb"
|
|
"G132A","L2","PZA","G","G132",132,"A",1,"XDR","DM","hydrophobic","hydrophobic","neutral","non-polar","non-polar","non-polar",6.912,-1.92,-0.829,5.5504,-2.927,-0.28,80,91,-1.191,9,9,0,0,"strand",2.76666666666667,8.75,0.0005749604714675,14.5802781289507,14.5802277940117,14.5801759034061,15.0663448164144,-4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-6,0,-6,-2,0,0,-7,-18,-0.486322188449848,-0.21421188630491,0.20215764974978,-0.499062233589088,-0.0732984293193717,0.842105263157895,-0.981054365733114,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","147/150","G",2.6796663501904,0.0010245352377104,0.816050632122417,3.28370108999367,3.35697961122016,99.5538692591549,1.16376580853041,0.0005075351447614,3.29453387923245,2.60435121163486,147.676327006136,0.0001037975122989,"lineage2","dr_mutations_pyrazinamide","ALA",0,"ERR2513241","ERR2513241","lineage2.2.1","gb","UK","pnca_p.gly132ala","A","E","GLY","GA132","pnca_complex.pdb"
|
|
"G132A","L4","PZA","G","G132",132,"A",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","neutral","non-polar","non-polar","non-polar",6.912,-1.92,-0.829,5.5504,-2.927,-0.28,80,91,-1.191,9,9,0,0,"strand",2.76666666666667,8.75,0.0005749604714675,14.5802781289507,14.5802277940117,14.5801759034061,15.0663448164144,-4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-6,0,-6,-2,0,0,-7,-18,-0.486322188449848,-0.21421188630491,0.20215764974978,-0.499062233589088,-0.0732984293193717,0.842105263157895,-0.981054365733114,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","147/150","G",2.6796663501904,0.0010245352377104,0.816050632122417,3.28370108999367,3.35697961122016,99.5538692591549,1.16376580853041,0.0005075351447614,3.29453387923245,2.60435121163486,147.676327006136,0.0001037975122989,"lineage4","dr_mutations_pyrazinamide","ALA",0,"SAMN02350485","SRR1140960_SRR1019161","lineage4.3.3","za","South Africa","pnca_p.gly132ala","A","E","GLY","GA132","pnca_complex.pdb"
|
|
"G132A","L4","PZA","G","G132",132,"A",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","neutral","non-polar","non-polar","non-polar",6.912,-1.92,-0.829,5.5504,-2.927,-0.28,80,91,-1.191,9,9,0,0,"strand",2.76666666666667,8.75,0.0005749604714675,14.5802781289507,14.5802277940117,14.5801759034061,15.0663448164144,-4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-6,0,-6,-2,0,0,-7,-18,-0.486322188449848,-0.21421188630491,0.20215764974978,-0.499062233589088,-0.0732984293193717,0.842105263157895,-0.981054365733114,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","147/150","G",2.6796663501904,0.0010245352377104,0.816050632122417,3.28370108999367,3.35697961122016,99.5538692591549,1.16376580853041,0.0005075351447614,3.29453387923245,2.60435121163486,147.676327006136,0.0001037975122989,"lineage4","dr_mutations_pyrazinamide","ALA",0,"SAMN02585978","SRR1180445_SRR1180356_SRR1181355_SRR1181262","lineage4.3.3","za","South Africa","pnca_p.gly132ala","A","E","GLY","GA132","pnca_complex.pdb"
|
|
"G132A","L4","PZA","G","G132",132,"A",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","neutral","non-polar","non-polar","non-polar",6.912,-1.92,-0.829,5.5504,-2.927,-0.28,80,91,-1.191,9,9,0,0,"strand",2.76666666666667,8.75,0.0005749604714675,14.5802781289507,14.5802277940117,14.5801759034061,15.0663448164144,-4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-6,0,-6,-2,0,0,-7,-18,-0.486322188449848,-0.21421188630491,0.20215764974978,-0.499062233589088,-0.0732984293193717,0.842105263157895,-0.981054365733114,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","147/150","G",2.6796663501904,0.0010245352377104,0.816050632122417,3.28370108999367,3.35697961122016,99.5538692591549,1.16376580853041,0.0005075351447614,3.29453387923245,2.60435121163486,147.676327006136,0.0001037975122989,"lineage4","dr_mutations_pyrazinamide","ALA",0,"SAMN02585965","SRR1180429_SRR1181145_SRR1180353_SRR1181108","lineage4.3.3","za","South Africa","pnca_p.gly132ala","A","E","GLY","GA132","pnca_complex.pdb"
|
|
"G132A","L4","PZA","G","G132",132,"A",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","neutral","non-polar","non-polar","non-polar",6.912,-1.92,-0.829,5.5504,-2.927,-0.28,80,91,-1.191,9,9,0,0,"strand",2.76666666666667,8.75,0.0005749604714675,14.5802781289507,14.5802277940117,14.5801759034061,15.0663448164144,-4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-6,0,-6,-2,0,0,-7,-18,-0.486322188449848,-0.21421188630491,0.20215764974978,-0.499062233589088,-0.0732984293193717,0.842105263157895,-0.981054365733114,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","147/150","G",2.6796663501904,0.0010245352377104,0.816050632122417,3.28370108999367,3.35697961122016,99.5538692591549,1.16376580853041,0.0005075351447614,3.29453387923245,2.60435121163486,147.676327006136,0.0001037975122989,"lineage4","dr_mutations_pyrazinamide","ALA",0,"SAMN02586040","SRR1184375_SRR1173294_SRR1173411_SRR1196525","lineage4.3.3","za","South Africa","pnca_p.gly132ala","A","E","GLY","GA132","pnca_complex.pdb"
|
|
"G132A","L2","PZA","G","G132",132,"A",1,"MDR","DM","hydrophobic","hydrophobic","neutral","non-polar","non-polar","non-polar",6.912,-1.92,-0.829,5.5504,-2.927,-0.28,80,91,-1.191,9,9,0,0,"strand",2.76666666666667,8.75,0.0005749604714675,14.5802781289507,14.5802277940117,14.5801759034061,15.0663448164144,-4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-6,0,-6,-2,0,0,-7,-18,-0.486322188449848,-0.21421188630491,0.20215764974978,-0.499062233589088,-0.0732984293193717,0.842105263157895,-0.981054365733114,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","147/150","G",2.6796663501904,0.0010245352377104,0.816050632122417,3.28370108999367,3.35697961122016,99.5538692591549,1.16376580853041,0.0005075351447614,3.29453387923245,2.60435121163486,147.676327006136,0.0001037975122989,"lineage2","dr_mutations_pyrazinamide","ALA",0,"ERR2517046","ERR2517046","lineage2.2.1","gb","UK","pnca_p.gly132ala","A","E","GLY","GA132","pnca_complex.pdb"
|
|
"G132D","L2","PZA","G","G132",132,"D",NA,"MDR","DM","hydrophobic","hydrophilic","neutral","acidic","non-polar","neg",6.912,-0.822,-2.518,18.6426,-3.507,-1.46,92,95,-1.191,9,9,0,0,"strand",2.76666666666667,8.75,0.0004312203536006,58.3312262958281,1393450.94022859,Inf,23.547488635408,-22,-42,0,-2,-40,0,0,0,0,0,0,0,0,0,0,0,0,-11,0,-9,-6,-4,0,-9,-23,-0.208206686930091,-0.650645994832041,0.679004071999359,-0.597953964194373,-0.382198952879581,0.968421052631579,-0.981054365733114,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","147/150","G",14.1472939191334,0.915018435775164,132.576060676564,0.106710773022948,4.17896182038204,NA,1.7659011066874,2.48532104922106e-05,4.60461750194108,5.71767556863798,Inf,1.21868387173808e-06,"lineage2","dr_mutations_pyrazinamide","ASP",0,"SAMN02414914","SRR1146372_SRR1144743_SRR1166918_SRR1162871","lineage2.2.1","se","Sweden","pnca_p.gly132asp","A","E","GLY","GA132","pnca_complex.pdb"
|
|
"G132D","L4","PZA","G","G132",132,"D",NA,"XDR","DM","hydrophobic","hydrophilic","neutral","acidic","non-polar","neg",6.912,-0.822,-2.518,18.6426,-3.507,-1.46,92,95,-1.191,9,9,0,0,"strand",2.76666666666667,8.75,0.0004312203536006,58.3312262958281,1393450.94022859,Inf,23.547488635408,-22,-42,0,-2,-40,0,0,0,0,0,0,0,0,0,0,0,0,-11,0,-9,-6,-4,0,-9,-23,-0.208206686930091,-0.650645994832041,0.679004071999359,-0.597953964194373,-0.382198952879581,0.968421052631579,-0.981054365733114,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","147/150","G",14.1472939191334,0.915018435775164,132.576060676564,0.106710773022948,4.17896182038204,NA,1.7659011066874,2.48532104922106e-05,4.60461750194108,5.71767556863798,Inf,1.21868387173808e-06,"lineage4","dr_mutations_pyrazinamide","ASP",0,"SAMN02628520","SRR1173843_SRR1173428","lineage4.3","ir","Iran","pnca_p.gly132asp","A","E","GLY","GA132","pnca_complex.pdb"
|
|
"G132D","L2","PZA","G","G132",132,"D",NA,"MDR","DM","hydrophobic","hydrophilic","neutral","acidic","non-polar","neg",6.912,-0.822,-2.518,18.6426,-3.507,-1.46,92,95,-1.191,9,9,0,0,"strand",2.76666666666667,8.75,0.0004312203536006,58.3312262958281,1393450.94022859,Inf,23.547488635408,-22,-42,0,-2,-40,0,0,0,0,0,0,0,0,0,0,0,0,-11,0,-9,-6,-4,0,-9,-23,-0.208206686930091,-0.650645994832041,0.679004071999359,-0.597953964194373,-0.382198952879581,0.968421052631579,-0.981054365733114,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","147/150","G",14.1472939191334,0.915018435775164,132.576060676564,0.106710773022948,4.17896182038204,NA,1.7659011066874,2.48532104922106e-05,4.60461750194108,5.71767556863798,Inf,1.21868387173808e-06,"lineage2","dr_mutations_pyrazinamide","ASP",0,"SAMN02414915","SRR1162851_SRR1146316_SRR1162806_SRR1144778","lineage2.2.1","se","Sweden","pnca_p.gly132asp","A","E","GLY","GA132","pnca_complex.pdb"
|
|
"G132D","L1","PZA","G","G132",132,"D",1,"Other","DM","hydrophobic","hydrophilic","neutral","acidic","non-polar","neg",6.912,-0.822,-2.518,18.6426,-3.507,-1.46,92,95,-1.191,9,9,0,0,"strand",2.76666666666667,8.75,0.0004312203536006,58.3312262958281,1393450.94022859,Inf,23.547488635408,-22,-42,0,-2,-40,0,0,0,0,0,0,0,0,0,0,0,0,-11,0,-9,-6,-4,0,-9,-23,-0.208206686930091,-0.650645994832041,0.679004071999359,-0.597953964194373,-0.382198952879581,0.968421052631579,-0.981054365733114,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","147/150","G",14.1472939191334,0.915018435775164,132.576060676564,0.106710773022948,4.17896182038204,NA,1.7659011066874,2.48532104922106e-05,4.60461750194108,5.71767556863798,Inf,1.21868387173808e-06,"lineage1","dr_mutations_pyrazinamide","ASP",0,"SAMN03647993,SRR2100820","SRR2100820","lineage1.2.2","","","pnca_p.gly132asp","A","E","GLY","GA132","pnca_complex.pdb"
|
|
"G132D","L1","PZA","G","G132",132,"D",NA,"Other","DM","hydrophobic","hydrophilic","neutral","acidic","non-polar","neg",6.912,-0.822,-2.518,18.6426,-3.507,-1.46,92,95,-1.191,9,9,0,0,"strand",2.76666666666667,8.75,0.0004312203536006,58.3312262958281,1393450.94022859,Inf,23.547488635408,-22,-42,0,-2,-40,0,0,0,0,0,0,0,0,0,0,0,0,-11,0,-9,-6,-4,0,-9,-23,-0.208206686930091,-0.650645994832041,0.679004071999359,-0.597953964194373,-0.382198952879581,0.968421052631579,-0.981054365733114,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","147/150","G",14.1472939191334,0.915018435775164,132.576060676564,0.106710773022948,4.17896182038204,NA,1.7659011066874,2.48532104922106e-05,4.60461750194108,5.71767556863798,Inf,1.21868387173808e-06,"lineage1","dr_mutations_pyrazinamide","ASP",0,"SAMN02599021","SRR1169488_SRR1172309_SRR1183033_SRR1180217","lineage1.2.2","in","India","pnca_p.gly132asp","A","E","GLY","GA132","pnca_complex.pdb"
|
|
"G132D","L2","PZA","G","G132",132,"D",1,"XDR","DM","hydrophobic","hydrophilic","neutral","acidic","non-polar","neg",6.912,-0.822,-2.518,18.6426,-3.507,-1.46,92,95,-1.191,9,9,0,0,"strand",2.76666666666667,8.75,0.0004312203536006,58.3312262958281,1393450.94022859,Inf,23.547488635408,-22,-42,0,-2,-40,0,0,0,0,0,0,0,0,0,0,0,0,-11,0,-9,-6,-4,0,-9,-23,-0.208206686930091,-0.650645994832041,0.679004071999359,-0.597953964194373,-0.382198952879581,0.968421052631579,-0.981054365733114,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","147/150","G",14.1472939191334,0.915018435775164,132.576060676564,0.106710773022948,4.17896182038204,NA,1.7659011066874,2.48532104922106e-05,4.60461750194108,5.71767556863798,Inf,1.21868387173808e-06,"lineage2","dr_mutations_pyrazinamide","ASP",0,"ERR2516994","ERR2516994","lineage2.2.1","gb","UK","pnca_p.gly132asp","A","E","GLY","GA132","pnca_complex.pdb"
|
|
"G132D","L2","PZA","G","G132",132,"D",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","neutral","acidic","non-polar","neg",6.912,-0.822,-2.518,18.6426,-3.507,-1.46,92,95,-1.191,9,9,0,0,"strand",2.76666666666667,8.75,0.0004312203536006,58.3312262958281,1393450.94022859,Inf,23.547488635408,-22,-42,0,-2,-40,0,0,0,0,0,0,0,0,0,0,0,0,-11,0,-9,-6,-4,0,-9,-23,-0.208206686930091,-0.650645994832041,0.679004071999359,-0.597953964194373,-0.382198952879581,0.968421052631579,-0.981054365733114,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","147/150","G",14.1472939191334,0.915018435775164,132.576060676564,0.106710773022948,4.17896182038204,NA,1.7659011066874,2.48532104922106e-05,4.60461750194108,5.71767556863798,Inf,1.21868387173808e-06,"lineage2","dr_mutations_pyrazinamide","ASP",0,"ERR502947","ERR502947","lineage2.2.1","","","pnca_p.gly132asp","A","E","GLY","GA132","pnca_complex.pdb"
|
|
"G132D","L2","PZA","G","G132",132,"D",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","neutral","acidic","non-polar","neg",6.912,-0.822,-2.518,18.6426,-3.507,-1.46,92,95,-1.191,9,9,0,0,"strand",2.76666666666667,8.75,0.0004312203536006,58.3312262958281,1393450.94022859,Inf,23.547488635408,-22,-42,0,-2,-40,0,0,0,0,0,0,0,0,0,0,0,0,-11,0,-9,-6,-4,0,-9,-23,-0.208206686930091,-0.650645994832041,0.679004071999359,-0.597953964194373,-0.382198952879581,0.968421052631579,-0.981054365733114,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","147/150","G",14.1472939191334,0.915018435775164,132.576060676564,0.106710773022948,4.17896182038204,NA,1.7659011066874,2.48532104922106e-05,4.60461750194108,5.71767556863798,Inf,1.21868387173808e-06,"lineage2","dr_mutations_pyrazinamide","ASP",0,"SRS936005,SAMN03653267","SRR2024965","lineage2.2.1","cn","China","pnca_p.gly132asp","A","E","GLY","GA132","pnca_complex.pdb"
|
|
"G132D","L1","PZA","G","G132",132,"D",NA,"Other","DM","hydrophobic","hydrophilic","neutral","acidic","non-polar","neg",6.912,-0.822,-2.518,18.6426,-3.507,-1.46,92,95,-1.191,9,9,0,0,"strand",2.76666666666667,8.75,0.0004312203536006,58.3312262958281,1393450.94022859,Inf,23.547488635408,-22,-42,0,-2,-40,0,0,0,0,0,0,0,0,0,0,0,0,-11,0,-9,-6,-4,0,-9,-23,-0.208206686930091,-0.650645994832041,0.679004071999359,-0.597953964194373,-0.382198952879581,0.968421052631579,-0.981054365733114,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","147/150","G",14.1472939191334,0.915018435775164,132.576060676564,0.106710773022948,4.17896182038204,NA,1.7659011066874,2.48532104922106e-05,4.60461750194108,5.71767556863798,Inf,1.21868387173808e-06,"lineage1","dr_mutations_pyrazinamide","ASP",0,"SAMN02599077","SRR1173584_SRR1173093","lineage1.2.2","in","India","pnca_p.gly132asp","A","E","GLY","GA132","pnca_complex.pdb"
|
|
"G132D","L2","PZA","G","G132",132,"D",NA,"MDR","DM","hydrophobic","hydrophilic","neutral","acidic","non-polar","neg",6.912,-0.822,-2.518,18.6426,-3.507,-1.46,92,95,-1.191,9,9,0,0,"strand",2.76666666666667,8.75,0.0004312203536006,58.3312262958281,1393450.94022859,Inf,23.547488635408,-22,-42,0,-2,-40,0,0,0,0,0,0,0,0,0,0,0,0,-11,0,-9,-6,-4,0,-9,-23,-0.208206686930091,-0.650645994832041,0.679004071999359,-0.597953964194373,-0.382198952879581,0.968421052631579,-0.981054365733114,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","147/150","G",14.1472939191334,0.915018435775164,132.576060676564,0.106710773022948,4.17896182038204,NA,1.7659011066874,2.48532104922106e-05,4.60461750194108,5.71767556863798,Inf,1.21868387173808e-06,"lineage2","dr_mutations_pyrazinamide","ASP",0,"SRS797122","SRR1723632","lineage2.2.1","cn","China:Chongqing","pnca_p.gly132asp","A","E","GLY","GA132","pnca_complex.pdb"
|
|
"G132D","L2","PZA","G","G132",132,"D",1,"Pre-XDR","DM","hydrophobic","hydrophilic","neutral","acidic","non-polar","neg",6.912,-0.822,-2.518,18.6426,-3.507,-1.46,92,95,-1.191,9,9,0,0,"strand",2.76666666666667,8.75,0.0004312203536006,58.3312262958281,1393450.94022859,Inf,23.547488635408,-22,-42,0,-2,-40,0,0,0,0,0,0,0,0,0,0,0,0,-11,0,-9,-6,-4,0,-9,-23,-0.208206686930091,-0.650645994832041,0.679004071999359,-0.597953964194373,-0.382198952879581,0.968421052631579,-0.981054365733114,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","147/150","G",14.1472939191334,0.915018435775164,132.576060676564,0.106710773022948,4.17896182038204,NA,1.7659011066874,2.48532104922106e-05,4.60461750194108,5.71767556863798,Inf,1.21868387173808e-06,"lineage2","dr_mutations_pyrazinamide","ASP",0,"MDR_22216","SRR6824601","lineage2.2.1","cn","China: Fengjie County, Chongqing","pnca_p.gly132asp","A","E","GLY","GA132","pnca_complex.pdb"
|
|
"G132D","L2","PZA","G","G132",132,"D",1,"MDR","DM","hydrophobic","hydrophilic","neutral","acidic","non-polar","neg",6.912,-0.822,-2.518,18.6426,-3.507,-1.46,92,95,-1.191,9,9,0,0,"strand",2.76666666666667,8.75,0.0004312203536006,58.3312262958281,1393450.94022859,Inf,23.547488635408,-22,-42,0,-2,-40,0,0,0,0,0,0,0,0,0,0,0,0,-11,0,-9,-6,-4,0,-9,-23,-0.208206686930091,-0.650645994832041,0.679004071999359,-0.597953964194373,-0.382198952879581,0.968421052631579,-0.981054365733114,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","147/150","G",14.1472939191334,0.915018435775164,132.576060676564,0.106710773022948,4.17896182038204,NA,1.7659011066874,2.48532104922106e-05,4.60461750194108,5.71767556863798,Inf,1.21868387173808e-06,"lineage2","dr_mutations_pyrazinamide","ASP",0,"MDR_22257","SRR6824361","lineage2.2.1","cn","China: Fengjie County, Chongqing","pnca_p.gly132asp","A","E","GLY","GA132","pnca_complex.pdb"
|
|
"G132D","L2","PZA","G","G132",132,"D",NA,"MDR","DM","hydrophobic","hydrophilic","neutral","acidic","non-polar","neg",6.912,-0.822,-2.518,18.6426,-3.507,-1.46,92,95,-1.191,9,9,0,0,"strand",2.76666666666667,8.75,0.0004312203536006,58.3312262958281,1393450.94022859,Inf,23.547488635408,-22,-42,0,-2,-40,0,0,0,0,0,0,0,0,0,0,0,0,-11,0,-9,-6,-4,0,-9,-23,-0.208206686930091,-0.650645994832041,0.679004071999359,-0.597953964194373,-0.382198952879581,0.968421052631579,-0.981054365733114,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","147/150","G",14.1472939191334,0.915018435775164,132.576060676564,0.106710773022948,4.17896182038204,NA,1.7659011066874,2.48532104922106e-05,4.60461750194108,5.71767556863798,Inf,1.21868387173808e-06,"lineage2","dr_mutations_pyrazinamide","ASP",0,"ERR502944","ERR502944","lineage2.2.1","","","pnca_p.gly132asp","A","E","GLY","GA132","pnca_complex.pdb"
|
|
"G132D","L2","PZA","G","G132",132,"D",1,"MDR","DM","hydrophobic","hydrophilic","neutral","acidic","non-polar","neg",6.912,-0.822,-2.518,18.6426,-3.507,-1.46,92,95,-1.191,9,9,0,0,"strand",2.76666666666667,8.75,0.0004312203536006,58.3312262958281,1393450.94022859,Inf,23.547488635408,-22,-42,0,-2,-40,0,0,0,0,0,0,0,0,0,0,0,0,-11,0,-9,-6,-4,0,-9,-23,-0.208206686930091,-0.650645994832041,0.679004071999359,-0.597953964194373,-0.382198952879581,0.968421052631579,-0.981054365733114,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","147/150","G",14.1472939191334,0.915018435775164,132.576060676564,0.106710773022948,4.17896182038204,NA,1.7659011066874,2.48532104922106e-05,4.60461750194108,5.71767556863798,Inf,1.21868387173808e-06,"lineage2","dr_mutations_pyrazinamide","ASP",0,"MDR_22268","SRR6824362","lineage2.2.1","cn","China: Fengjie County, Chongqing","pnca_p.gly132asp","A","E","GLY","GA132","pnca_complex.pdb"
|
|
"G132D","L2","PZA","G","G132",132,"D",NA,"MDR","DM","hydrophobic","hydrophilic","neutral","acidic","non-polar","neg",6.912,-0.822,-2.518,18.6426,-3.507,-1.46,92,95,-1.191,9,9,0,0,"strand",2.76666666666667,8.75,0.0004312203536006,58.3312262958281,1393450.94022859,Inf,23.547488635408,-22,-42,0,-2,-40,0,0,0,0,0,0,0,0,0,0,0,0,-11,0,-9,-6,-4,0,-9,-23,-0.208206686930091,-0.650645994832041,0.679004071999359,-0.597953964194373,-0.382198952879581,0.968421052631579,-0.981054365733114,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","147/150","G",14.1472939191334,0.915018435775164,132.576060676564,0.106710773022948,4.17896182038204,NA,1.7659011066874,2.48532104922106e-05,4.60461750194108,5.71767556863798,Inf,1.21868387173808e-06,"lineage2","dr_mutations_pyrazinamide","ASP",0,"SRS797123","SRR1723633","lineage2.2.1","cn","China:Chongqing","pnca_p.gly132asp","A","E","GLY","GA132","pnca_complex.pdb"
|
|
"G132D","L1","PZA","G","G132",132,"D",1,"Other","DM","hydrophobic","hydrophilic","neutral","acidic","non-polar","neg",6.912,-0.822,-2.518,18.6426,-3.507,-1.46,92,95,-1.191,9,9,0,0,"strand",2.76666666666667,8.75,0.0004312203536006,58.3312262958281,1393450.94022859,Inf,23.547488635408,-22,-42,0,-2,-40,0,0,0,0,0,0,0,0,0,0,0,0,-11,0,-9,-6,-4,0,-9,-23,-0.208206686930091,-0.650645994832041,0.679004071999359,-0.597953964194373,-0.382198952879581,0.968421052631579,-0.981054365733114,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","147/150","G",14.1472939191334,0.915018435775164,132.576060676564,0.106710773022948,4.17896182038204,NA,1.7659011066874,2.48532104922106e-05,4.60461750194108,5.71767556863798,Inf,1.21868387173808e-06,"lineage1","dr_mutations_pyrazinamide","ASP",0,"ERR2514483","ERR2514483","lineage1.2.2","gb","UK","pnca_p.gly132asp","A","E","GLY","GA132","pnca_complex.pdb"
|
|
"G132D","L2","PZA","G","G132",132,"D",NA,"MDR","DM","hydrophobic","hydrophilic","neutral","acidic","non-polar","neg",6.912,-0.822,-2.518,18.6426,-3.507,-1.46,92,95,-1.191,9,9,0,0,"strand",2.76666666666667,8.75,0.0004312203536006,58.3312262958281,1393450.94022859,Inf,23.547488635408,-22,-42,0,-2,-40,0,0,0,0,0,0,0,0,0,0,0,0,-11,0,-9,-6,-4,0,-9,-23,-0.208206686930091,-0.650645994832041,0.679004071999359,-0.597953964194373,-0.382198952879581,0.968421052631579,-0.981054365733114,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","147/150","G",14.1472939191334,0.915018435775164,132.576060676564,0.106710773022948,4.17896182038204,NA,1.7659011066874,2.48532104922106e-05,4.60461750194108,5.71767556863798,Inf,1.21868387173808e-06,"lineage2","dr_mutations_pyrazinamide","ASP",0,"SRS935935,SAMN03653300","SRR2024882","lineage2.2.1","cn","China","pnca_p.gly132asp","A","E","GLY","GA132","pnca_complex.pdb"
|
|
"G132D","L2","PZA","G","G132",132,"D",NA,"MDR","DM","hydrophobic","hydrophilic","neutral","acidic","non-polar","neg",6.912,-0.822,-2.518,18.6426,-3.507,-1.46,92,95,-1.191,9,9,0,0,"strand",2.76666666666667,8.75,0.0004312203536006,58.3312262958281,1393450.94022859,Inf,23.547488635408,-22,-42,0,-2,-40,0,0,0,0,0,0,0,0,0,0,0,0,-11,0,-9,-6,-4,0,-9,-23,-0.208206686930091,-0.650645994832041,0.679004071999359,-0.597953964194373,-0.382198952879581,0.968421052631579,-0.981054365733114,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","147/150","G",14.1472939191334,0.915018435775164,132.576060676564,0.106710773022948,4.17896182038204,NA,1.7659011066874,2.48532104922106e-05,4.60461750194108,5.71767556863798,Inf,1.21868387173808e-06,"lineage2","dr_mutations_pyrazinamide","ASP",0,"SAMN03653305,SRS935921","SRR2024887","lineage2.2.1","cn","China","pnca_p.gly132asp","A","E","GLY","GA132","pnca_complex.pdb"
|
|
"G132D","L2","PZA","G","G132",132,"D",NA,"MDR","DM","hydrophobic","hydrophilic","neutral","acidic","non-polar","neg",6.912,-0.822,-2.518,18.6426,-3.507,-1.46,92,95,-1.191,9,9,0,0,"strand",2.76666666666667,8.75,0.0004312203536006,58.3312262958281,1393450.94022859,Inf,23.547488635408,-22,-42,0,-2,-40,0,0,0,0,0,0,0,0,0,0,0,0,-11,0,-9,-6,-4,0,-9,-23,-0.208206686930091,-0.650645994832041,0.679004071999359,-0.597953964194373,-0.382198952879581,0.968421052631579,-0.981054365733114,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","147/150","G",14.1472939191334,0.915018435775164,132.576060676564,0.106710773022948,4.17896182038204,NA,1.7659011066874,2.48532104922106e-05,4.60461750194108,5.71767556863798,Inf,1.21868387173808e-06,"lineage2","dr_mutations_pyrazinamide","ASP",0,"ERR502949","ERR502949","lineage2.2.1","","","pnca_p.gly132asp","A","E","GLY","GA132","pnca_complex.pdb"
|
|
"G132D","L2","PZA","G","G132",132,"D",NA,"XDR","DM","hydrophobic","hydrophilic","neutral","acidic","non-polar","neg",6.912,-0.822,-2.518,18.6426,-3.507,-1.46,92,95,-1.191,9,9,0,0,"strand",2.76666666666667,8.75,0.0004312203536006,58.3312262958281,1393450.94022859,Inf,23.547488635408,-22,-42,0,-2,-40,0,0,0,0,0,0,0,0,0,0,0,0,-11,0,-9,-6,-4,0,-9,-23,-0.208206686930091,-0.650645994832041,0.679004071999359,-0.597953964194373,-0.382198952879581,0.968421052631579,-0.981054365733114,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","147/150","G",14.1472939191334,0.915018435775164,132.576060676564,0.106710773022948,4.17896182038204,NA,1.7659011066874,2.48532104922106e-05,4.60461750194108,5.71767556863798,Inf,1.21868387173808e-06,"lineage2","dr_mutations_pyrazinamide","ASP",0,"ERR158607","ERR158607","lineage2.2.1","gb","UK","pnca_p.gly132asp","A","E","GLY","GA132","pnca_complex.pdb"
|
|
"G132S","L4","PZA","G","G132",132,"S",1,"MDR","DM","hydrophobic","hydrophilic","neutral","neutral","non-polar","polar",6.912,-0.312,-2.061,10.5344,-3.165,-1.17,85,91,-1.191,9,9,0,0,"strand",2.76666666666667,8.75,0.0005749604714675,77.8405735976381,1394626.35224766,Inf,33.1802749271012,-4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-8,0,-8,-4,0,0,-7,-19,-0.0790273556231003,-0.532558139534884,0.383685778596872,-0.539641943734015,-0.306282722513089,0.894736842105263,-0.981054365733114,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","147/150","G",14.1481370895088,0.901927875940771,114.814237034556,0.123226330243789,82.9586021393604,NA,1.89120602753485,7.2326389241213e-07,6.1407032156959,8.29603358299821,Inf,8.39983046099388e-09,"lineage4","dr_mutations_pyrazinamide","SER",0,"ERR2515345","ERR2515345","lineage4.1.1.3","za","South Africa","pnca_p.gly132ser","A","E","GLY","GA132","pnca_complex.pdb"
|
|
"G132S","L4","PZA","G","G132",132,"S",1,"Pre-XDR","DM","hydrophobic","hydrophilic","neutral","neutral","non-polar","polar",6.912,-0.312,-2.061,10.5344,-3.165,-1.17,85,91,-1.191,9,9,0,0,"strand",2.76666666666667,8.75,0.0005749604714675,77.8405735976381,1394626.35224766,Inf,33.1802749271012,-4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-8,0,-8,-4,0,0,-7,-19,-0.0790273556231003,-0.532558139534884,0.383685778596872,-0.539641943734015,-0.306282722513089,0.894736842105263,-0.981054365733114,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","147/150","G",14.1481370895088,0.901927875940771,114.814237034556,0.123226330243789,82.9586021393604,NA,1.89120602753485,7.2326389241213e-07,6.1407032156959,8.29603358299821,Inf,8.39983046099388e-09,"lineage4","dr_mutations_pyrazinamide","SER",0,"ERR550619","ERR550619","lineage4.1.1.3","sz","Swaziland","pnca_p.gly132ser","A","E","GLY","GA132","pnca_complex.pdb"
|
|
"G132S","L3","PZA","G","G132",132,"S",1,"Pre-XDR","DM","hydrophobic","hydrophilic","neutral","neutral","non-polar","polar",6.912,-0.312,-2.061,10.5344,-3.165,-1.17,85,91,-1.191,9,9,0,0,"strand",2.76666666666667,8.75,0.0005749604714675,77.8405735976381,1394626.35224766,Inf,33.1802749271012,-4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-8,0,-8,-4,0,0,-7,-19,-0.0790273556231003,-0.532558139534884,0.383685778596872,-0.539641943734015,-0.306282722513089,0.894736842105263,-0.981054365733114,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","147/150","G",14.1481370895088,0.901927875940771,114.814237034556,0.123226330243789,82.9586021393604,NA,1.89120602753485,7.2326389241213e-07,6.1407032156959,8.29603358299821,Inf,8.39983046099388e-09,"lineage3","dr_mutations_pyrazinamide","SER",0,"ERR2510517","ERR2510517","lineage3","pk","Pakistan","pnca_p.gly132ser","A","E","GLY","GA132","pnca_complex.pdb"
|
|
"G132S","L4","PZA","G","G132",132,"S",1,"Pre-XDR","DM","hydrophobic","hydrophilic","neutral","neutral","non-polar","polar",6.912,-0.312,-2.061,10.5344,-3.165,-1.17,85,91,-1.191,9,9,0,0,"strand",2.76666666666667,8.75,0.0005749604714675,77.8405735976381,1394626.35224766,Inf,33.1802749271012,-4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-8,0,-8,-4,0,0,-7,-19,-0.0790273556231003,-0.532558139534884,0.383685778596872,-0.539641943734015,-0.306282722513089,0.894736842105263,-0.981054365733114,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","147/150","G",14.1481370895088,0.901927875940771,114.814237034556,0.123226330243789,82.9586021393604,NA,1.89120602753485,7.2326389241213e-07,6.1407032156959,8.29603358299821,Inf,8.39983046099388e-09,"lineage4","dr_mutations_pyrazinamide","SER",0,"ERR2515474","ERR2515474","lineage4.1.1.3","za","South Africa","pnca_p.gly132ser","A","E","GLY","GA132","pnca_complex.pdb"
|
|
"G132S","L4","PZA","G","G132",132,"S",1,"Pre-XDR","DM","hydrophobic","hydrophilic","neutral","neutral","non-polar","polar",6.912,-0.312,-2.061,10.5344,-3.165,-1.17,85,91,-1.191,9,9,0,0,"strand",2.76666666666667,8.75,0.0005749604714675,77.8405735976381,1394626.35224766,Inf,33.1802749271012,-4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-8,0,-8,-4,0,0,-7,-19,-0.0790273556231003,-0.532558139534884,0.383685778596872,-0.539641943734015,-0.306282722513089,0.894736842105263,-0.981054365733114,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","147/150","G",14.1481370895088,0.901927875940771,114.814237034556,0.123226330243789,82.9586021393604,NA,1.89120602753485,7.2326389241213e-07,6.1407032156959,8.29603358299821,Inf,8.39983046099388e-09,"lineage4","dr_mutations_pyrazinamide","SER",0,"ERR2516025","ERR2516025","lineage4.1.1.3","za","South Africa","pnca_p.gly132ser","A","E","GLY","GA132","pnca_complex.pdb"
|
|
"G132S","L3","PZA","G","G132",132,"S",1,"MDR","DM","hydrophobic","hydrophilic","neutral","neutral","non-polar","polar",6.912,-0.312,-2.061,10.5344,-3.165,-1.17,85,91,-1.191,9,9,0,0,"strand",2.76666666666667,8.75,0.0005749604714675,77.8405735976381,1394626.35224766,Inf,33.1802749271012,-4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-8,0,-8,-4,0,0,-7,-19,-0.0790273556231003,-0.532558139534884,0.383685778596872,-0.539641943734015,-0.306282722513089,0.894736842105263,-0.981054365733114,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","147/150","G",14.1481370895088,0.901927875940771,114.814237034556,0.123226330243789,82.9586021393604,NA,1.89120602753485,7.2326389241213e-07,6.1407032156959,8.29603358299821,Inf,8.39983046099388e-09,"lineage3","dr_mutations_pyrazinamide","SER",0,"ERR2510506","ERR2510506","lineage3","pk","Pakistan","pnca_p.gly132ser","A","E","GLY","GA132","pnca_complex.pdb"
|
|
"G132S","L4","PZA","G","G132",132,"S",1,"Pre-XDR","DM","hydrophobic","hydrophilic","neutral","neutral","non-polar","polar",6.912,-0.312,-2.061,10.5344,-3.165,-1.17,85,91,-1.191,9,9,0,0,"strand",2.76666666666667,8.75,0.0005749604714675,77.8405735976381,1394626.35224766,Inf,33.1802749271012,-4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-8,0,-8,-4,0,0,-7,-19,-0.0790273556231003,-0.532558139534884,0.383685778596872,-0.539641943734015,-0.306282722513089,0.894736842105263,-0.981054365733114,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","147/150","G",14.1481370895088,0.901927875940771,114.814237034556,0.123226330243789,82.9586021393604,NA,1.89120602753485,7.2326389241213e-07,6.1407032156959,8.29603358299821,Inf,8.39983046099388e-09,"lineage4","dr_mutations_pyrazinamide","SER",0,"ERR551692","ERR551692","lineage4.1.1.3","sz","Swaziland","pnca_p.gly132ser","A","E","GLY","GA132","pnca_complex.pdb"
|
|
"G132S","L4","PZA","G","G132",132,"S",1,"MDR","DM","hydrophobic","hydrophilic","neutral","neutral","non-polar","polar",6.912,-0.312,-2.061,10.5344,-3.165,-1.17,85,91,-1.191,9,9,0,0,"strand",2.76666666666667,8.75,0.0005749604714675,77.8405735976381,1394626.35224766,Inf,33.1802749271012,-4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-8,0,-8,-4,0,0,-7,-19,-0.0790273556231003,-0.532558139534884,0.383685778596872,-0.539641943734015,-0.306282722513089,0.894736842105263,-0.981054365733114,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.229,-1.178,"9:9","147/150","G",14.1481370895088,0.901927875940771,114.814237034556,0.123226330243789,82.9586021393604,NA,1.89120602753485,7.2326389241213e-07,6.1407032156959,8.29603358299821,Inf,8.39983046099388e-09,"lineage4","dr_mutations_pyrazinamide","SER",0,"ERR552518","ERR552518","lineage4.1.1.3","sz","Swaziland","pnca_p.gly132ser","A","E","GLY","GA132","pnca_complex.pdb"
|
|
"I133S","L2","PZA","I","I133",133,"S",NA,"XDR","OM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",3.05,0.578,-3.219,3.30196,-2.461,-3.47,70,85,-0.739,8,8,3,0.015228426395939,"strand",1.96666666666667,7.9,7.18700589334483e-05,9.70142977291842,188179.926264589,Inf,0.763784339928386,34,0,0,0,0,0,0,0,0,-2,0,-2,0,0,0,0,0,0,0,0,0,6,0,8,0,0.259192825112108,-0.831782945736434,0.120264570691803,-0.419607843137255,-0.908376963350785,0.736842105263158,-0.608731466227348,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.872,-0.674,"8:7","147/150","V:L:I:M:F",12.1451538387262,0.919026337424226,119.468044436218,0.101660271548266,5.01153666064073e-06,NA,0.986835744238421,0.170978870202674,0.767057556984365,0.124324963210678,Inf,0.382146811758261,"lineage2","other_mutations_pyrazinamide","SER",0,"SAMN07236533,SRR5709884","SRR5709884","lineage2.2.1","th","Thailand","pnca_p.ile133ser","A","E","ILE","IA133","pnca_complex.pdb"
|
|
"I133S","L2","PZA","I","I133",133,"S",1,"XDR","OM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",3.05,0.578,-3.219,3.30196,-2.461,-3.47,70,85,-0.739,8,8,3,0.015228426395939,"strand",1.96666666666667,7.9,7.18700589334483e-05,9.70142977291842,188179.926264589,Inf,0.763784339928386,34,0,0,0,0,0,0,0,0,-2,0,-2,0,0,0,0,0,0,0,0,0,6,0,8,0,0.259192825112108,-0.831782945736434,0.120264570691803,-0.419607843137255,-0.908376963350785,0.736842105263158,-0.608731466227348,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.872,-0.674,"8:7","147/150","V:L:I:M:F",12.1451538387262,0.919026337424226,119.468044436218,0.101660271548266,5.01153666064073e-06,NA,0.986835744238421,0.170978870202674,0.767057556984365,0.124324963210678,Inf,0.382146811758261,"lineage2","other_mutations_pyrazinamide","SER",0,"ERR1034861","ERR1034861","lineage2.2.1","pt","Portugal","pnca_p.ile133ser","A","E","ILE","IA133","pnca_complex.pdb"
|
|
"I133S","L4","PZA","I","I133",133,"S",NA,"Pre-XDR","OM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",3.05,0.578,-3.219,3.30196,-2.461,-3.47,70,85,-0.739,8,8,3,0.015228426395939,"strand",1.96666666666667,7.9,7.18700589334483e-05,9.70142977291842,188179.926264589,Inf,0.763784339928386,34,0,0,0,0,0,0,0,0,-2,0,-2,0,0,0,0,0,0,0,0,0,6,0,8,0,0.259192825112108,-0.831782945736434,0.120264570691803,-0.419607843137255,-0.908376963350785,0.736842105263158,-0.608731466227348,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.872,-0.674,"8:7","147/150","V:L:I:M:F",12.1451538387262,0.919026337424226,119.468044436218,0.101660271548266,5.01153666064073e-06,NA,0.986835744238421,0.170978870202674,0.767057556984365,0.124324963210678,Inf,0.382146811758261,"lineage4","other_mutations_pyrazinamide","SER",0,"ERR1035286","ERR1035286","lineage4.1.2.1","br","Brazil","pnca_p.ile133ser","A","E","ILE","IA133","pnca_complex.pdb"
|
|
"I133T","L2","PZA","I","I133",133,"T",1,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",3.05,0.703,-2.788,1.57844,-1.862,-2.56,68,80,-0.739,8,8,3,0.015228426395939,"strand",1.96666666666667,7.9,0.0031622825930717,6.43697178374994,6.43697172567821,6.43569721125883,46.3588997045238,34,0,0,0,0,0,0,0,0,-2,0,-2,0,0,0,0,0,0,0,0,0,4,0,4,0,0.3152466367713,-0.720413436692506,0.0574902206455467,-0.317476555839727,-0.670157068062827,0.715789473684211,-0.608731466227348,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.872,-0.674,"8:7","147/150","V:L:I:M:F",1.86205820059201,1.05183177238756e-09,0.305188422646507,6.10133957390906,3.55222271070208,11.8555583489231,0.808681605417837,2.90039620895666e-09,8.53754267120101,3.39739251160169,12.3875045168727,9.84592753332283e-12,"lineage2","dr_mutations_pyrazinamide","THR",0,"ERS457609","ERR551811_ERR551810_ERR551809","lineage2.2.1","uz","Nukus","pnca_p.ile133thr","A","E","ILE","IA133","pnca_complex.pdb"
|
|
"I133T","L2","PZA","I","I133",133,"T",1,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",3.05,0.703,-2.788,1.57844,-1.862,-2.56,68,80,-0.739,8,8,3,0.015228426395939,"strand",1.96666666666667,7.9,0.0031622825930717,6.43697178374994,6.43697172567821,6.43569721125883,46.3588997045238,34,0,0,0,0,0,0,0,0,-2,0,-2,0,0,0,0,0,0,0,0,0,4,0,4,0,0.3152466367713,-0.720413436692506,0.0574902206455467,-0.317476555839727,-0.670157068062827,0.715789473684211,-0.608731466227348,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.872,-0.674,"8:7","147/150","V:L:I:M:F",1.86205820059201,1.05183177238756e-09,0.305188422646507,6.10133957390906,3.55222271070208,11.8555583489231,0.808681605417837,2.90039620895666e-09,8.53754267120101,3.39739251160169,12.3875045168727,9.84592753332283e-12,"lineage2","dr_mutations_pyrazinamide","THR",0,"SAMEA2535005,ERS458407","ERR552926_ERR552927","lineage2.2.1","uz","Nukus","pnca_p.ile133thr","A","E","ILE","IA133","pnca_complex.pdb"
|
|
"I133T","L2","PZA","I","I133",133,"T",NA,"XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",3.05,0.703,-2.788,1.57844,-1.862,-2.56,68,80,-0.739,8,8,3,0.015228426395939,"strand",1.96666666666667,7.9,0.0031622825930717,6.43697178374994,6.43697172567821,6.43569721125883,46.3588997045238,34,0,0,0,0,0,0,0,0,-2,0,-2,0,0,0,0,0,0,0,0,0,4,0,4,0,0.3152466367713,-0.720413436692506,0.0574902206455467,-0.317476555839727,-0.670157068062827,0.715789473684211,-0.608731466227348,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.872,-0.674,"8:7","147/150","V:L:I:M:F",1.86205820059201,1.05183177238756e-09,0.305188422646507,6.10133957390906,3.55222271070208,11.8555583489231,0.808681605417837,2.90039620895666e-09,8.53754267120101,3.39739251160169,12.3875045168727,9.84592753332283e-12,"lineage2","dr_mutations_pyrazinamide","THR",0,"SRR7517822","SRR7517822","lineage2.2.1","ch","Switzerland","pnca_p.ile133thr","A","E","ILE","IA133","pnca_complex.pdb"
|
|
"I133T","L2","PZA","I","I133",133,"T",1,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",3.05,0.703,-2.788,1.57844,-1.862,-2.56,68,80,-0.739,8,8,3,0.015228426395939,"strand",1.96666666666667,7.9,0.0031622825930717,6.43697178374994,6.43697172567821,6.43569721125883,46.3588997045238,34,0,0,0,0,0,0,0,0,-2,0,-2,0,0,0,0,0,0,0,0,0,4,0,4,0,0.3152466367713,-0.720413436692506,0.0574902206455467,-0.317476555839727,-0.670157068062827,0.715789473684211,-0.608731466227348,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.872,-0.674,"8:7","147/150","V:L:I:M:F",1.86205820059201,1.05183177238756e-09,0.305188422646507,6.10133957390906,3.55222271070208,11.8555583489231,0.808681605417837,2.90039620895666e-09,8.53754267120101,3.39739251160169,12.3875045168727,9.84592753332283e-12,"lineage2","dr_mutations_pyrazinamide","THR",0,"ERS456846","ERR550751_ERR550750_ERR550752","lineage2.2.1","uz","Nukus","pnca_p.ile133thr","A","E","ILE","IA133","pnca_complex.pdb"
|
|
"I133T","L2","PZA","I","I133",133,"T",0,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",3.05,0.703,-2.788,1.57844,-1.862,-2.56,68,80,-0.739,8,8,3,0.015228426395939,"strand",1.96666666666667,7.9,0.0031622825930717,6.43697178374994,6.43697172567821,6.43569721125883,46.3588997045238,34,0,0,0,0,0,0,0,0,-2,0,-2,0,0,0,0,0,0,0,0,0,4,0,4,0,0.3152466367713,-0.720413436692506,0.0574902206455467,-0.317476555839727,-0.670157068062827,0.715789473684211,-0.608731466227348,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.872,-0.674,"8:7","147/150","V:L:I:M:F",1.86205820059201,1.05183177238756e-09,0.305188422646507,6.10133957390906,3.55222271070208,11.8555583489231,0.808681605417837,2.90039620895666e-09,8.53754267120101,3.39739251160169,12.3875045168727,9.84592753332283e-12,"lineage2","dr_mutations_pyrazinamide","THR",0,"SAMEA2533585,ERS456987","ERR550949_ERR550950","lineage2.2.1","uz","Nukus","pnca_p.ile133thr","A","E","ILE","IA133","pnca_complex.pdb"
|
|
"I133T","L2","PZA","I","I133",133,"T",1,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",3.05,0.703,-2.788,1.57844,-1.862,-2.56,68,80,-0.739,8,8,3,0.015228426395939,"strand",1.96666666666667,7.9,0.0031622825930717,6.43697178374994,6.43697172567821,6.43569721125883,46.3588997045238,34,0,0,0,0,0,0,0,0,-2,0,-2,0,0,0,0,0,0,0,0,0,4,0,4,0,0.3152466367713,-0.720413436692506,0.0574902206455467,-0.317476555839727,-0.670157068062827,0.715789473684211,-0.608731466227348,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.872,-0.674,"8:7","147/150","V:L:I:M:F",1.86205820059201,1.05183177238756e-09,0.305188422646507,6.10133957390906,3.55222271070208,11.8555583489231,0.808681605417837,2.90039620895666e-09,8.53754267120101,3.39739251160169,12.3875045168727,9.84592753332283e-12,"lineage2","dr_mutations_pyrazinamide","THR",0,"ERS456907,SAMEA2533505","ERR550829_ERR550830","lineage2.2.1","uz","Nukus","pnca_p.ile133thr","A","E","ILE","IA133","pnca_complex.pdb"
|
|
"I133T","L2","PZA","I","I133",133,"T",1,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",3.05,0.703,-2.788,1.57844,-1.862,-2.56,68,80,-0.739,8,8,3,0.015228426395939,"strand",1.96666666666667,7.9,0.0031622825930717,6.43697178374994,6.43697172567821,6.43569721125883,46.3588997045238,34,0,0,0,0,0,0,0,0,-2,0,-2,0,0,0,0,0,0,0,0,0,4,0,4,0,0.3152466367713,-0.720413436692506,0.0574902206455467,-0.317476555839727,-0.670157068062827,0.715789473684211,-0.608731466227348,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.872,-0.674,"8:7","147/150","V:L:I:M:F",1.86205820059201,1.05183177238756e-09,0.305188422646507,6.10133957390906,3.55222271070208,11.8555583489231,0.808681605417837,2.90039620895666e-09,8.53754267120101,3.39739251160169,12.3875045168727,9.84592753332283e-12,"lineage2","dr_mutations_pyrazinamide","THR",0,"SAMEA2534415,ERS457817","ERR552103_ERR552104","lineage2.2.1","uz","Nukus","pnca_p.ile133thr","A","E","ILE","IA133","pnca_complex.pdb"
|
|
"I133T","L2","PZA","I","I133",133,"T",1,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",3.05,0.703,-2.788,1.57844,-1.862,-2.56,68,80,-0.739,8,8,3,0.015228426395939,"strand",1.96666666666667,7.9,0.0031622825930717,6.43697178374994,6.43697172567821,6.43569721125883,46.3588997045238,34,0,0,0,0,0,0,0,0,-2,0,-2,0,0,0,0,0,0,0,0,0,4,0,4,0,0.3152466367713,-0.720413436692506,0.0574902206455467,-0.317476555839727,-0.670157068062827,0.715789473684211,-0.608731466227348,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.872,-0.674,"8:7","147/150","V:L:I:M:F",1.86205820059201,1.05183177238756e-09,0.305188422646507,6.10133957390906,3.55222271070208,11.8555583489231,0.808681605417837,2.90039620895666e-09,8.53754267120101,3.39739251160169,12.3875045168727,9.84592753332283e-12,"lineage2","dr_mutations_pyrazinamide","THR",0,"SAMEA2533879,ERS457281","ERR551352_ERR551353","lineage2.2.1","uz","Nukus","pnca_p.ile133thr","A","E","ILE","IA133","pnca_complex.pdb"
|
|
"I133T","L2","PZA","I","I133",133,"T",1,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",3.05,0.703,-2.788,1.57844,-1.862,-2.56,68,80,-0.739,8,8,3,0.015228426395939,"strand",1.96666666666667,7.9,0.0031622825930717,6.43697178374994,6.43697172567821,6.43569721125883,46.3588997045238,34,0,0,0,0,0,0,0,0,-2,0,-2,0,0,0,0,0,0,0,0,0,4,0,4,0,0.3152466367713,-0.720413436692506,0.0574902206455467,-0.317476555839727,-0.670157068062827,0.715789473684211,-0.608731466227348,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.872,-0.674,"8:7","147/150","V:L:I:M:F",1.86205820059201,1.05183177238756e-09,0.305188422646507,6.10133957390906,3.55222271070208,11.8555583489231,0.808681605417837,2.90039620895666e-09,8.53754267120101,3.39739251160169,12.3875045168727,9.84592753332283e-12,"lineage2","dr_mutations_pyrazinamide","THR",0,"ERS458500","ERR553051_ERR553050","lineage2.2.1","uz","Nukus","pnca_p.ile133thr","A","E","ILE","IA133","pnca_complex.pdb"
|
|
"I133T","L4","PZA","I","I133",133,"T",1,"XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",3.05,0.703,-2.788,1.57844,-1.862,-2.56,68,80,-0.739,8,8,3,0.015228426395939,"strand",1.96666666666667,7.9,0.0031622825930717,6.43697178374994,6.43697172567821,6.43569721125883,46.3588997045238,34,0,0,0,0,0,0,0,0,-2,0,-2,0,0,0,0,0,0,0,0,0,4,0,4,0,0.3152466367713,-0.720413436692506,0.0574902206455467,-0.317476555839727,-0.670157068062827,0.715789473684211,-0.608731466227348,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.872,-0.674,"8:7","147/150","V:L:I:M:F",1.86205820059201,1.05183177238756e-09,0.305188422646507,6.10133957390906,3.55222271070208,11.8555583489231,0.808681605417837,2.90039620895666e-09,8.53754267120101,3.39739251160169,12.3875045168727,9.84592753332283e-12,"lineage4","dr_mutations_pyrazinamide","THR",0,"ERR1035175","ERR1035175","lineage4.3.4.2","pt","Portugal","pnca_p.ile133thr","A","E","ILE","IA133","pnca_complex.pdb"
|
|
"I133T","L2","PZA","I","I133",133,"T",0,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",3.05,0.703,-2.788,1.57844,-1.862,-2.56,68,80,-0.739,8,8,3,0.015228426395939,"strand",1.96666666666667,7.9,0.0031622825930717,6.43697178374994,6.43697172567821,6.43569721125883,46.3588997045238,34,0,0,0,0,0,0,0,0,-2,0,-2,0,0,0,0,0,0,0,0,0,4,0,4,0,0.3152466367713,-0.720413436692506,0.0574902206455467,-0.317476555839727,-0.670157068062827,0.715789473684211,-0.608731466227348,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.872,-0.674,"8:7","147/150","V:L:I:M:F",1.86205820059201,1.05183177238756e-09,0.305188422646507,6.10133957390906,3.55222271070208,11.8555583489231,0.808681605417837,2.90039620895666e-09,8.53754267120101,3.39739251160169,12.3875045168727,9.84592753332283e-12,"lineage2","dr_mutations_pyrazinamide","THR",0,"SAMEA2533368,ERS456770","ERR550651_ERR550652","lineage2.2.1","uz","Nukus","pnca_p.ile133thr","A","E","ILE","IA133","pnca_complex.pdb"
|
|
"I133T","L2","PZA","I","I133",133,"T",1,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",3.05,0.703,-2.788,1.57844,-1.862,-2.56,68,80,-0.739,8,8,3,0.015228426395939,"strand",1.96666666666667,7.9,0.0031622825930717,6.43697178374994,6.43697172567821,6.43569721125883,46.3588997045238,34,0,0,0,0,0,0,0,0,-2,0,-2,0,0,0,0,0,0,0,0,0,4,0,4,0,0.3152466367713,-0.720413436692506,0.0574902206455467,-0.317476555839727,-0.670157068062827,0.715789473684211,-0.608731466227348,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.872,-0.674,"8:7","147/150","V:L:I:M:F",1.86205820059201,1.05183177238756e-09,0.305188422646507,6.10133957390906,3.55222271070208,11.8555583489231,0.808681605417837,2.90039620895666e-09,8.53754267120101,3.39739251160169,12.3875045168727,9.84592753332283e-12,"lineage2","dr_mutations_pyrazinamide","THR",0,"ERS457258,SAMEA2533856","ERR551320_ERR551321","lineage2.2.1","uz","Nukus","pnca_p.ile133thr","A","E","ILE","IA133","pnca_complex.pdb"
|
|
"I133T","L2","PZA","I","I133",133,"T",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",3.05,0.703,-2.788,1.57844,-1.862,-2.56,68,80,-0.739,8,8,3,0.015228426395939,"strand",1.96666666666667,7.9,0.0031622825930717,6.43697178374994,6.43697172567821,6.43569721125883,46.3588997045238,34,0,0,0,0,0,0,0,0,-2,0,-2,0,0,0,0,0,0,0,0,0,4,0,4,0,0.3152466367713,-0.720413436692506,0.0574902206455467,-0.317476555839727,-0.670157068062827,0.715789473684211,-0.608731466227348,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.872,-0.674,"8:7","147/150","V:L:I:M:F",1.86205820059201,1.05183177238756e-09,0.305188422646507,6.10133957390906,3.55222271070208,11.8555583489231,0.808681605417837,2.90039620895666e-09,8.53754267120101,3.39739251160169,12.3875045168727,9.84592753332283e-12,"lineage2","dr_mutations_pyrazinamide","THR",0,"ERR718273","ERR718273","lineage2.2.1","th","Thailand","pnca_p.ile133thr","A","E","ILE","IA133","pnca_complex.pdb"
|
|
"I133T","L2","PZA","I","I133",133,"T",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",3.05,0.703,-2.788,1.57844,-1.862,-2.56,68,80,-0.739,8,8,3,0.015228426395939,"strand",1.96666666666667,7.9,0.0031622825930717,6.43697178374994,6.43697172567821,6.43569721125883,46.3588997045238,34,0,0,0,0,0,0,0,0,-2,0,-2,0,0,0,0,0,0,0,0,0,4,0,4,0,0.3152466367713,-0.720413436692506,0.0574902206455467,-0.317476555839727,-0.670157068062827,0.715789473684211,-0.608731466227348,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.872,-0.674,"8:7","147/150","V:L:I:M:F",1.86205820059201,1.05183177238756e-09,0.305188422646507,6.10133957390906,3.55222271070208,11.8555583489231,0.808681605417837,2.90039620895666e-09,8.53754267120101,3.39739251160169,12.3875045168727,9.84592753332283e-12,"lineage2","dr_mutations_pyrazinamide","THR",0,"SRR6079937","SRR6079937","lineage2.2.1.1","au","","pnca_p.ile133thr","A","E","ILE","IA133","pnca_complex.pdb"
|
|
"I133T","L2","PZA","I","I133",133,"T",0,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",3.05,0.703,-2.788,1.57844,-1.862,-2.56,68,80,-0.739,8,8,3,0.015228426395939,"strand",1.96666666666667,7.9,0.0031622825930717,6.43697178374994,6.43697172567821,6.43569721125883,46.3588997045238,34,0,0,0,0,0,0,0,0,-2,0,-2,0,0,0,0,0,0,0,0,0,4,0,4,0,0.3152466367713,-0.720413436692506,0.0574902206455467,-0.317476555839727,-0.670157068062827,0.715789473684211,-0.608731466227348,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.872,-0.674,"8:7","147/150","V:L:I:M:F",1.86205820059201,1.05183177238756e-09,0.305188422646507,6.10133957390906,3.55222271070208,11.8555583489231,0.808681605417837,2.90039620895666e-09,8.53754267120101,3.39739251160169,12.3875045168727,9.84592753332283e-12,"lineage2","dr_mutations_pyrazinamide","THR",0,"SAMEA2533596,ERS456998","ERR550960_ERR550961","lineage2.2.1","uz","Nukus","pnca_p.ile133thr","A","E","ILE","IA133","pnca_complex.pdb"
|
|
"I133T","L2","PZA","I","I133",133,"T",1,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",3.05,0.703,-2.788,1.57844,-1.862,-2.56,68,80,-0.739,8,8,3,0.015228426395939,"strand",1.96666666666667,7.9,0.0031622825930717,6.43697178374994,6.43697172567821,6.43569721125883,46.3588997045238,34,0,0,0,0,0,0,0,0,-2,0,-2,0,0,0,0,0,0,0,0,0,4,0,4,0,0.3152466367713,-0.720413436692506,0.0574902206455467,-0.317476555839727,-0.670157068062827,0.715789473684211,-0.608731466227348,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.872,-0.674,"8:7","147/150","V:L:I:M:F",1.86205820059201,1.05183177238756e-09,0.305188422646507,6.10133957390906,3.55222271070208,11.8555583489231,0.808681605417837,2.90039620895666e-09,8.53754267120101,3.39739251160169,12.3875045168727,9.84592753332283e-12,"lineage2","dr_mutations_pyrazinamide","THR",0,"ERS457709","ERR551944_ERR551945_ERR551943","lineage2.2.1","uz","Nukus","pnca_p.ile133thr","A","E","ILE","IA133","pnca_complex.pdb"
|
|
"I133T","L2","PZA","I","I133",133,"T",NA,"XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",3.05,0.703,-2.788,1.57844,-1.862,-2.56,68,80,-0.739,8,8,3,0.015228426395939,"strand",1.96666666666667,7.9,0.0031622825930717,6.43697178374994,6.43697172567821,6.43569721125883,46.3588997045238,34,0,0,0,0,0,0,0,0,-2,0,-2,0,0,0,0,0,0,0,0,0,4,0,4,0,0.3152466367713,-0.720413436692506,0.0574902206455467,-0.317476555839727,-0.670157068062827,0.715789473684211,-0.608731466227348,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.872,-0.674,"8:7","147/150","V:L:I:M:F",1.86205820059201,1.05183177238756e-09,0.305188422646507,6.10133957390906,3.55222271070208,11.8555583489231,0.808681605417837,2.90039620895666e-09,8.53754267120101,3.39739251160169,12.3875045168727,9.84592753332283e-12,"lineage2","dr_mutations_pyrazinamide","THR",0,"ERR751552","ERR751552","lineage2.2.1","pe","","pnca_p.ile133thr","A","E","ILE","IA133","pnca_complex.pdb"
|
|
"I133T","L2","PZA","I","I133",133,"T",0,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",3.05,0.703,-2.788,1.57844,-1.862,-2.56,68,80,-0.739,8,8,3,0.015228426395939,"strand",1.96666666666667,7.9,0.0031622825930717,6.43697178374994,6.43697172567821,6.43569721125883,46.3588997045238,34,0,0,0,0,0,0,0,0,-2,0,-2,0,0,0,0,0,0,0,0,0,4,0,4,0,0.3152466367713,-0.720413436692506,0.0574902206455467,-0.317476555839727,-0.670157068062827,0.715789473684211,-0.608731466227348,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.872,-0.674,"8:7","147/150","V:L:I:M:F",1.86205820059201,1.05183177238756e-09,0.305188422646507,6.10133957390906,3.55222271070208,11.8555583489231,0.808681605417837,2.90039620895666e-09,8.53754267120101,3.39739251160169,12.3875045168727,9.84592753332283e-12,"lineage2","dr_mutations_pyrazinamide","THR",0,"ERS457343","ERR551437_ERR551436","lineage2.2.1","uz","Nukus","pnca_p.ile133thr","A","E","ILE","IA133","pnca_complex.pdb"
|
|
"I133T","L2","PZA","I","I133",133,"T",0,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",3.05,0.703,-2.788,1.57844,-1.862,-2.56,68,80,-0.739,8,8,3,0.015228426395939,"strand",1.96666666666667,7.9,0.0031622825930717,6.43697178374994,6.43697172567821,6.43569721125883,46.3588997045238,34,0,0,0,0,0,0,0,0,-2,0,-2,0,0,0,0,0,0,0,0,0,4,0,4,0,0.3152466367713,-0.720413436692506,0.0574902206455467,-0.317476555839727,-0.670157068062827,0.715789473684211,-0.608731466227348,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.872,-0.674,"8:7","147/150","V:L:I:M:F",1.86205820059201,1.05183177238756e-09,0.305188422646507,6.10133957390906,3.55222271070208,11.8555583489231,0.808681605417837,2.90039620895666e-09,8.53754267120101,3.39739251160169,12.3875045168727,9.84592753332283e-12,"lineage2","dr_mutations_pyrazinamide","THR",0,"ERS458264","ERR552741_ERR552740","lineage2.2.1","uz","Nukus","pnca_p.ile133thr","A","E","ILE","IA133","pnca_complex.pdb"
|
|
"I133T","L2","PZA","I","I133",133,"T",1,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",3.05,0.703,-2.788,1.57844,-1.862,-2.56,68,80,-0.739,8,8,3,0.015228426395939,"strand",1.96666666666667,7.9,0.0031622825930717,6.43697178374994,6.43697172567821,6.43569721125883,46.3588997045238,34,0,0,0,0,0,0,0,0,-2,0,-2,0,0,0,0,0,0,0,0,0,4,0,4,0,0.3152466367713,-0.720413436692506,0.0574902206455467,-0.317476555839727,-0.670157068062827,0.715789473684211,-0.608731466227348,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.872,-0.674,"8:7","147/150","V:L:I:M:F",1.86205820059201,1.05183177238756e-09,0.305188422646507,6.10133957390906,3.55222271070208,11.8555583489231,0.808681605417837,2.90039620895666e-09,8.53754267120101,3.39739251160169,12.3875045168727,9.84592753332283e-12,"lineage2","dr_mutations_pyrazinamide","THR",0,"2214H-sc-2012-10-11T13:38:42Z-1494220,ERR228056","ERR228056","lineage2.2.1","ru","Russia,Samara","pnca_p.ile133thr","A","E","ILE","IA133","pnca_complex.pdb"
|
|
"I133T","L2","PZA","I","I133",133,"T",1,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",3.05,0.703,-2.788,1.57844,-1.862,-2.56,68,80,-0.739,8,8,3,0.015228426395939,"strand",1.96666666666667,7.9,0.0031622825930717,6.43697178374994,6.43697172567821,6.43569721125883,46.3588997045238,34,0,0,0,0,0,0,0,0,-2,0,-2,0,0,0,0,0,0,0,0,0,4,0,4,0,0.3152466367713,-0.720413436692506,0.0574902206455467,-0.317476555839727,-0.670157068062827,0.715789473684211,-0.608731466227348,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.872,-0.674,"8:7","147/150","V:L:I:M:F",1.86205820059201,1.05183177238756e-09,0.305188422646507,6.10133957390906,3.55222271070208,11.8555583489231,0.808681605417837,2.90039620895666e-09,8.53754267120101,3.39739251160169,12.3875045168727,9.84592753332283e-12,"lineage2","dr_mutations_pyrazinamide","THR",0,"ERS458394","ERR552906_ERR552907_ERR552905_ERR552909_ERR552908","lineage2.2.1","uz","Nukus","pnca_p.ile133thr","A","E","ILE","IA133","pnca_complex.pdb"
|
|
"I133T","L2","PZA","I","I133",133,"T",1,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",3.05,0.703,-2.788,1.57844,-1.862,-2.56,68,80,-0.739,8,8,3,0.015228426395939,"strand",1.96666666666667,7.9,0.0031622825930717,6.43697178374994,6.43697172567821,6.43569721125883,46.3588997045238,34,0,0,0,0,0,0,0,0,-2,0,-2,0,0,0,0,0,0,0,0,0,4,0,4,0,0.3152466367713,-0.720413436692506,0.0574902206455467,-0.317476555839727,-0.670157068062827,0.715789473684211,-0.608731466227348,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.872,-0.674,"8:7","147/150","V:L:I:M:F",1.86205820059201,1.05183177238756e-09,0.305188422646507,6.10133957390906,3.55222271070208,11.8555583489231,0.808681605417837,2.90039620895666e-09,8.53754267120101,3.39739251160169,12.3875045168727,9.84592753332283e-12,"lineage2","dr_mutations_pyrazinamide","THR",0,"SAMEA2534205,ERS457607","ERR551804_ERR551805_ERR551806","lineage2.2.1","uz","Nukus","pnca_p.ile133thr","A","E","ILE","IA133","pnca_complex.pdb"
|
|
"I133T","L2","PZA","I","I133",133,"T",1,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",3.05,0.703,-2.788,1.57844,-1.862,-2.56,68,80,-0.739,8,8,3,0.015228426395939,"strand",1.96666666666667,7.9,0.0031622825930717,6.43697178374994,6.43697172567821,6.43569721125883,46.3588997045238,34,0,0,0,0,0,0,0,0,-2,0,-2,0,0,0,0,0,0,0,0,0,4,0,4,0,0.3152466367713,-0.720413436692506,0.0574902206455467,-0.317476555839727,-0.670157068062827,0.715789473684211,-0.608731466227348,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.872,-0.674,"8:7","147/150","V:L:I:M:F",1.86205820059201,1.05183177238756e-09,0.305188422646507,6.10133957390906,3.55222271070208,11.8555583489231,0.808681605417837,2.90039620895666e-09,8.53754267120101,3.39739251160169,12.3875045168727,9.84592753332283e-12,"lineage2","dr_mutations_pyrazinamide","THR",0,"ERS457559","ERR551738_ERR551737","lineage2.2.1","uz","Nukus","pnca_p.ile133thr","A","E","ILE","IA133","pnca_complex.pdb"
|
|
"I133T","L2","PZA","I","I133",133,"T",1,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",3.05,0.703,-2.788,1.57844,-1.862,-2.56,68,80,-0.739,8,8,3,0.015228426395939,"strand",1.96666666666667,7.9,0.0031622825930717,6.43697178374994,6.43697172567821,6.43569721125883,46.3588997045238,34,0,0,0,0,0,0,0,0,-2,0,-2,0,0,0,0,0,0,0,0,0,4,0,4,0,0.3152466367713,-0.720413436692506,0.0574902206455467,-0.317476555839727,-0.670157068062827,0.715789473684211,-0.608731466227348,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.872,-0.674,"8:7","147/150","V:L:I:M:F",1.86205820059201,1.05183177238756e-09,0.305188422646507,6.10133957390906,3.55222271070208,11.8555583489231,0.808681605417837,2.90039620895666e-09,8.53754267120101,3.39739251160169,12.3875045168727,9.84592753332283e-12,"lineage2","dr_mutations_pyrazinamide","THR",0,"ERR550812,ERS456891,SAMEA2533489","ERR550812","lineage2.2.1","uz","Nukus","pnca_p.ile133thr","A","E","ILE","IA133","pnca_complex.pdb"
|
|
"I133T","L2","PZA","I","I133",133,"T",1,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",3.05,0.703,-2.788,1.57844,-1.862,-2.56,68,80,-0.739,8,8,3,0.015228426395939,"strand",1.96666666666667,7.9,0.0031622825930717,6.43697178374994,6.43697172567821,6.43569721125883,46.3588997045238,34,0,0,0,0,0,0,0,0,-2,0,-2,0,0,0,0,0,0,0,0,0,4,0,4,0,0.3152466367713,-0.720413436692506,0.0574902206455467,-0.317476555839727,-0.670157068062827,0.715789473684211,-0.608731466227348,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.872,-0.674,"8:7","147/150","V:L:I:M:F",1.86205820059201,1.05183177238756e-09,0.305188422646507,6.10133957390906,3.55222271070208,11.8555583489231,0.808681605417837,2.90039620895666e-09,8.53754267120101,3.39739251160169,12.3875045168727,9.84592753332283e-12,"lineage2","dr_mutations_pyrazinamide","THR",0,"ERS457728","ERR551974_ERR551973","lineage2.2.1","uz","Nukus","pnca_p.ile133thr","A","E","ILE","IA133","pnca_complex.pdb"
|
|
"I133T","L2","PZA","I","I133",133,"T",1,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",3.05,0.703,-2.788,1.57844,-1.862,-2.56,68,80,-0.739,8,8,3,0.015228426395939,"strand",1.96666666666667,7.9,0.0031622825930717,6.43697178374994,6.43697172567821,6.43569721125883,46.3588997045238,34,0,0,0,0,0,0,0,0,-2,0,-2,0,0,0,0,0,0,0,0,0,4,0,4,0,0.3152466367713,-0.720413436692506,0.0574902206455467,-0.317476555839727,-0.670157068062827,0.715789473684211,-0.608731466227348,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.872,-0.674,"8:7","147/150","V:L:I:M:F",1.86205820059201,1.05183177238756e-09,0.305188422646507,6.10133957390906,3.55222271070208,11.8555583489231,0.808681605417837,2.90039620895666e-09,8.53754267120101,3.39739251160169,12.3875045168727,9.84592753332283e-12,"lineage2","dr_mutations_pyrazinamide","THR",0,"SAMEA2533776,ERS457178","ERR551210_ERR551211","lineage2.2.1","uz","Nukus","pnca_p.ile133thr","A","E","ILE","IA133","pnca_complex.pdb"
|
|
"I133T","L2","PZA","I","I133",133,"T",0,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",3.05,0.703,-2.788,1.57844,-1.862,-2.56,68,80,-0.739,8,8,3,0.015228426395939,"strand",1.96666666666667,7.9,0.0031622825930717,6.43697178374994,6.43697172567821,6.43569721125883,46.3588997045238,34,0,0,0,0,0,0,0,0,-2,0,-2,0,0,0,0,0,0,0,0,0,4,0,4,0,0.3152466367713,-0.720413436692506,0.0574902206455467,-0.317476555839727,-0.670157068062827,0.715789473684211,-0.608731466227348,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.872,-0.674,"8:7","147/150","V:L:I:M:F",1.86205820059201,1.05183177238756e-09,0.305188422646507,6.10133957390906,3.55222271070208,11.8555583489231,0.808681605417837,2.90039620895666e-09,8.53754267120101,3.39739251160169,12.3875045168727,9.84592753332283e-12,"lineage2","dr_mutations_pyrazinamide","THR",0,"SAMEA2533664,ERS457066","ERR551051_ERR551052","lineage2.2.1","uz","Nukus","pnca_p.ile133thr","A","E","ILE","IA133","pnca_complex.pdb"
|
|
"I133T","L2","PZA","I","I133",133,"T",0,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",3.05,0.703,-2.788,1.57844,-1.862,-2.56,68,80,-0.739,8,8,3,0.015228426395939,"strand",1.96666666666667,7.9,0.0031622825930717,6.43697178374994,6.43697172567821,6.43569721125883,46.3588997045238,34,0,0,0,0,0,0,0,0,-2,0,-2,0,0,0,0,0,0,0,0,0,4,0,4,0,0.3152466367713,-0.720413436692506,0.0574902206455467,-0.317476555839727,-0.670157068062827,0.715789473684211,-0.608731466227348,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.872,-0.674,"8:7","147/150","V:L:I:M:F",1.86205820059201,1.05183177238756e-09,0.305188422646507,6.10133957390906,3.55222271070208,11.8555583489231,0.808681605417837,2.90039620895666e-09,8.53754267120101,3.39739251160169,12.3875045168727,9.84592753332283e-12,"lineage2","dr_mutations_pyrazinamide","THR",0,"ERS457172","ERR551199","lineage2.2.1","uz","Nukus","pnca_p.ile133thr","A","E","ILE","IA133","pnca_complex.pdb"
|
|
"I133T","L2","PZA","I","I133",133,"T",0,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",3.05,0.703,-2.788,1.57844,-1.862,-2.56,68,80,-0.739,8,8,3,0.015228426395939,"strand",1.96666666666667,7.9,0.0031622825930717,6.43697178374994,6.43697172567821,6.43569721125883,46.3588997045238,34,0,0,0,0,0,0,0,0,-2,0,-2,0,0,0,0,0,0,0,0,0,4,0,4,0,0.3152466367713,-0.720413436692506,0.0574902206455467,-0.317476555839727,-0.670157068062827,0.715789473684211,-0.608731466227348,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.872,-0.674,"8:7","147/150","V:L:I:M:F",1.86205820059201,1.05183177238756e-09,0.305188422646507,6.10133957390906,3.55222271070208,11.8555583489231,0.808681605417837,2.90039620895666e-09,8.53754267120101,3.39739251160169,12.3875045168727,9.84592753332283e-12,"lineage2","dr_mutations_pyrazinamide","THR",0,"ERS457216,SAMEA2533814","ERR551258_ERR551259","lineage2.2.1","uz","Nukus","pnca_p.ile133thr","A","E","ILE","IA133","pnca_complex.pdb"
|
|
"I133T","L2","PZA","I","I133",133,"T",0,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",3.05,0.703,-2.788,1.57844,-1.862,-2.56,68,80,-0.739,8,8,3,0.015228426395939,"strand",1.96666666666667,7.9,0.0031622825930717,6.43697178374994,6.43697172567821,6.43569721125883,46.3588997045238,34,0,0,0,0,0,0,0,0,-2,0,-2,0,0,0,0,0,0,0,0,0,4,0,4,0,0.3152466367713,-0.720413436692506,0.0574902206455467,-0.317476555839727,-0.670157068062827,0.715789473684211,-0.608731466227348,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.872,-0.674,"8:7","147/150","V:L:I:M:F",1.86205820059201,1.05183177238756e-09,0.305188422646507,6.10133957390906,3.55222271070208,11.8555583489231,0.808681605417837,2.90039620895666e-09,8.53754267120101,3.39739251160169,12.3875045168727,9.84592753332283e-12,"lineage2","dr_mutations_pyrazinamide","THR",0,"ERS457599","ERR551795_ERR551794_ERR551793","lineage2.2.1","uz","Nukus","pnca_p.ile133thr","A","E","ILE","IA133","pnca_complex.pdb"
|
|
"I133T","L2","PZA","I","I133",133,"T",0,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",3.05,0.703,-2.788,1.57844,-1.862,-2.56,68,80,-0.739,8,8,3,0.015228426395939,"strand",1.96666666666667,7.9,0.0031622825930717,6.43697178374994,6.43697172567821,6.43569721125883,46.3588997045238,34,0,0,0,0,0,0,0,0,-2,0,-2,0,0,0,0,0,0,0,0,0,4,0,4,0,0.3152466367713,-0.720413436692506,0.0574902206455467,-0.317476555839727,-0.670157068062827,0.715789473684211,-0.608731466227348,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.872,-0.674,"8:7","147/150","V:L:I:M:F",1.86205820059201,1.05183177238756e-09,0.305188422646507,6.10133957390906,3.55222271070208,11.8555583489231,0.808681605417837,2.90039620895666e-09,8.53754267120101,3.39739251160169,12.3875045168727,9.84592753332283e-12,"lineage2","dr_mutations_pyrazinamide","THR",0,"SAMEA2534058,ERS457460","ERR551599_ERR551600","lineage2.2.1","uz","Nukus","pnca_p.ile133thr","A","E","ILE","IA133","pnca_complex.pdb"
|
|
"I133T","L2","PZA","I","I133",133,"T",0,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",3.05,0.703,-2.788,1.57844,-1.862,-2.56,68,80,-0.739,8,8,3,0.015228426395939,"strand",1.96666666666667,7.9,0.0031622825930717,6.43697178374994,6.43697172567821,6.43569721125883,46.3588997045238,34,0,0,0,0,0,0,0,0,-2,0,-2,0,0,0,0,0,0,0,0,0,4,0,4,0,0.3152466367713,-0.720413436692506,0.0574902206455467,-0.317476555839727,-0.670157068062827,0.715789473684211,-0.608731466227348,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.872,-0.674,"8:7","147/150","V:L:I:M:F",1.86205820059201,1.05183177238756e-09,0.305188422646507,6.10133957390906,3.55222271070208,11.8555583489231,0.808681605417837,2.90039620895666e-09,8.53754267120101,3.39739251160169,12.3875045168727,9.84592753332283e-12,"lineage2","dr_mutations_pyrazinamide","THR",0,"ERS457618,SAMEA2534216","ERR551821_ERR551822","lineage2.2.1","uz","Nukus","pnca_p.ile133thr","A","E","ILE","IA133","pnca_complex.pdb"
|
|
"I133T","L2","PZA","I","I133",133,"T",1,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",3.05,0.703,-2.788,1.57844,-1.862,-2.56,68,80,-0.739,8,8,3,0.015228426395939,"strand",1.96666666666667,7.9,0.0031622825930717,6.43697178374994,6.43697172567821,6.43569721125883,46.3588997045238,34,0,0,0,0,0,0,0,0,-2,0,-2,0,0,0,0,0,0,0,0,0,4,0,4,0,0.3152466367713,-0.720413436692506,0.0574902206455467,-0.317476555839727,-0.670157068062827,0.715789473684211,-0.608731466227348,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.872,-0.674,"8:7","147/150","V:L:I:M:F",1.86205820059201,1.05183177238756e-09,0.305188422646507,6.10133957390906,3.55222271070208,11.8555583489231,0.808681605417837,2.90039620895666e-09,8.53754267120101,3.39739251160169,12.3875045168727,9.84592753332283e-12,"lineage2","dr_mutations_pyrazinamide","THR",0,"ERS457128,SAMEA2533726","ERR551137_ERR551138","lineage2.2.1","uz","Nukus","pnca_p.ile133thr","A","E","ILE","IA133","pnca_complex.pdb"
|
|
"I133T","L2","PZA","I","I133",133,"T",1,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",3.05,0.703,-2.788,1.57844,-1.862,-2.56,68,80,-0.739,8,8,3,0.015228426395939,"strand",1.96666666666667,7.9,0.0031622825930717,6.43697178374994,6.43697172567821,6.43569721125883,46.3588997045238,34,0,0,0,0,0,0,0,0,-2,0,-2,0,0,0,0,0,0,0,0,0,4,0,4,0,0.3152466367713,-0.720413436692506,0.0574902206455467,-0.317476555839727,-0.670157068062827,0.715789473684211,-0.608731466227348,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.872,-0.674,"8:7","147/150","V:L:I:M:F",1.86205820059201,1.05183177238756e-09,0.305188422646507,6.10133957390906,3.55222271070208,11.8555583489231,0.808681605417837,2.90039620895666e-09,8.53754267120101,3.39739251160169,12.3875045168727,9.84592753332283e-12,"lineage2","dr_mutations_pyrazinamide","THR",0,"ERS458326","ERR552816_ERR552815_ERR552814","lineage2.2.1","uz","Nukus","pnca_p.ile133thr","A","E","ILE","IA133","pnca_complex.pdb"
|
|
"I133T","L2","PZA","I","I133",133,"T",1,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",3.05,0.703,-2.788,1.57844,-1.862,-2.56,68,80,-0.739,8,8,3,0.015228426395939,"strand",1.96666666666667,7.9,0.0031622825930717,6.43697178374994,6.43697172567821,6.43569721125883,46.3588997045238,34,0,0,0,0,0,0,0,0,-2,0,-2,0,0,0,0,0,0,0,0,0,4,0,4,0,0.3152466367713,-0.720413436692506,0.0574902206455467,-0.317476555839727,-0.670157068062827,0.715789473684211,-0.608731466227348,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.872,-0.674,"8:7","147/150","V:L:I:M:F",1.86205820059201,1.05183177238756e-09,0.305188422646507,6.10133957390906,3.55222271070208,11.8555583489231,0.808681605417837,2.90039620895666e-09,8.53754267120101,3.39739251160169,12.3875045168727,9.84592753332283e-12,"lineage2","dr_mutations_pyrazinamide","THR",0,"ERS457118,SAMEA2533716,ERR551121","ERR551121","lineage2.2.1","uz","Nukus","pnca_p.ile133thr","A","E","ILE","IA133","pnca_complex.pdb"
|
|
"I133T","L2","PZA","I","I133",133,"T",0,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",3.05,0.703,-2.788,1.57844,-1.862,-2.56,68,80,-0.739,8,8,3,0.015228426395939,"strand",1.96666666666667,7.9,0.0031622825930717,6.43697178374994,6.43697172567821,6.43569721125883,46.3588997045238,34,0,0,0,0,0,0,0,0,-2,0,-2,0,0,0,0,0,0,0,0,0,4,0,4,0,0.3152466367713,-0.720413436692506,0.0574902206455467,-0.317476555839727,-0.670157068062827,0.715789473684211,-0.608731466227348,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.872,-0.674,"8:7","147/150","V:L:I:M:F",1.86205820059201,1.05183177238756e-09,0.305188422646507,6.10133957390906,3.55222271070208,11.8555583489231,0.808681605417837,2.90039620895666e-09,8.53754267120101,3.39739251160169,12.3875045168727,9.84592753332283e-12,"lineage2","dr_mutations_pyrazinamide","THR",0,"SAMEA2533610,ERS457012","ERR550980_ERR550981","lineage2.2.1","uz","Nukus","pnca_p.ile133thr","A","E","ILE","IA133","pnca_complex.pdb"
|
|
"I133T","L2","PZA","I","I133",133,"T",0,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",3.05,0.703,-2.788,1.57844,-1.862,-2.56,68,80,-0.739,8,8,3,0.015228426395939,"strand",1.96666666666667,7.9,0.0031622825930717,6.43697178374994,6.43697172567821,6.43569721125883,46.3588997045238,34,0,0,0,0,0,0,0,0,-2,0,-2,0,0,0,0,0,0,0,0,0,4,0,4,0,0.3152466367713,-0.720413436692506,0.0574902206455467,-0.317476555839727,-0.670157068062827,0.715789473684211,-0.608731466227348,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.872,-0.674,"8:7","147/150","V:L:I:M:F",1.86205820059201,1.05183177238756e-09,0.305188422646507,6.10133957390906,3.55222271070208,11.8555583489231,0.808681605417837,2.90039620895666e-09,8.53754267120101,3.39739251160169,12.3875045168727,9.84592753332283e-12,"lineage2","dr_mutations_pyrazinamide","THR",0,"ERS457300","ERR551378_ERR551377_ERR551379","lineage2.2.1","uz","Nukus","pnca_p.ile133thr","A","E","ILE","IA133","pnca_complex.pdb"
|
|
"I133T","L2","PZA","I","I133",133,"T",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",3.05,0.703,-2.788,1.57844,-1.862,-2.56,68,80,-0.739,8,8,3,0.015228426395939,"strand",1.96666666666667,7.9,0.0031622825930717,6.43697178374994,6.43697172567821,6.43569721125883,46.3588997045238,34,0,0,0,0,0,0,0,0,-2,0,-2,0,0,0,0,0,0,0,0,0,4,0,4,0,0.3152466367713,-0.720413436692506,0.0574902206455467,-0.317476555839727,-0.670157068062827,0.715789473684211,-0.608731466227348,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.872,-0.674,"8:7","147/150","V:L:I:M:F",1.86205820059201,1.05183177238756e-09,0.305188422646507,6.10133957390906,3.55222271070208,11.8555583489231,0.808681605417837,2.90039620895666e-09,8.53754267120101,3.39739251160169,12.3875045168727,9.84592753332283e-12,"lineage2","dr_mutations_pyrazinamide","THR",0,"SRR7898220","SRR7898220","lineage2.2.1","in","India","pnca_p.ile133thr","A","E","ILE","IA133","pnca_complex.pdb"
|
|
"I133T","L2","PZA","I","I133",133,"T",0,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",3.05,0.703,-2.788,1.57844,-1.862,-2.56,68,80,-0.739,8,8,3,0.015228426395939,"strand",1.96666666666667,7.9,0.0031622825930717,6.43697178374994,6.43697172567821,6.43569721125883,46.3588997045238,34,0,0,0,0,0,0,0,0,-2,0,-2,0,0,0,0,0,0,0,0,0,4,0,4,0,0.3152466367713,-0.720413436692506,0.0574902206455467,-0.317476555839727,-0.670157068062827,0.715789473684211,-0.608731466227348,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.872,-0.674,"8:7","147/150","V:L:I:M:F",1.86205820059201,1.05183177238756e-09,0.305188422646507,6.10133957390906,3.55222271070208,11.8555583489231,0.808681605417837,2.90039620895666e-09,8.53754267120101,3.39739251160169,12.3875045168727,9.84592753332283e-12,"lineage2","dr_mutations_pyrazinamide","THR",0,"ERS456944","ERR550887_ERR550883_ERR550886_ERR550884_ERR550882_ERR550885","lineage2.2.1","uz","Nukus","pnca_p.ile133thr","A","E","ILE","IA133","pnca_complex.pdb"
|
|
"I133T","L4","PZA","I","I133",133,"T",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",3.05,0.703,-2.788,1.57844,-1.862,-2.56,68,80,-0.739,8,8,3,0.015228426395939,"strand",1.96666666666667,7.9,0.0031622825930717,6.43697178374994,6.43697172567821,6.43569721125883,46.3588997045238,34,0,0,0,0,0,0,0,0,-2,0,-2,0,0,0,0,0,0,0,0,0,4,0,4,0,0.3152466367713,-0.720413436692506,0.0574902206455467,-0.317476555839727,-0.670157068062827,0.715789473684211,-0.608731466227348,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.872,-0.674,"8:7","147/150","V:L:I:M:F",1.86205820059201,1.05183177238756e-09,0.305188422646507,6.10133957390906,3.55222271070208,11.8555583489231,0.808681605417837,2.90039620895666e-09,8.53754267120101,3.39739251160169,12.3875045168727,9.84592753332283e-12,"lineage4","dr_mutations_pyrazinamide","THR",0,"ERR3256127","ERR3256127","lineage4.1.1.3","ph","Philippines","pnca_p.ile133thr","A","E","ILE","IA133","pnca_complex.pdb"
|
|
"I133T","L2","PZA","I","I133",133,"T",0,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",3.05,0.703,-2.788,1.57844,-1.862,-2.56,68,80,-0.739,8,8,3,0.015228426395939,"strand",1.96666666666667,7.9,0.0031622825930717,6.43697178374994,6.43697172567821,6.43569721125883,46.3588997045238,34,0,0,0,0,0,0,0,0,-2,0,-2,0,0,0,0,0,0,0,0,0,4,0,4,0,0.3152466367713,-0.720413436692506,0.0574902206455467,-0.317476555839727,-0.670157068062827,0.715789473684211,-0.608731466227348,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.872,-0.674,"8:7","147/150","V:L:I:M:F",1.86205820059201,1.05183177238756e-09,0.305188422646507,6.10133957390906,3.55222271070208,11.8555583489231,0.808681605417837,2.90039620895666e-09,8.53754267120101,3.39739251160169,12.3875045168727,9.84592753332283e-12,"lineage2","dr_mutations_pyrazinamide","THR",0,"ERS457488","ERR551638_ERR551639_ERR551637_ERR551641_ERR551640","lineage2.2.1","uz","Nukus","pnca_p.ile133thr","A","E","ILE","IA133","pnca_complex.pdb"
|
|
"I133T","L2","PZA","I","I133",133,"T",0,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",3.05,0.703,-2.788,1.57844,-1.862,-2.56,68,80,-0.739,8,8,3,0.015228426395939,"strand",1.96666666666667,7.9,0.0031622825930717,6.43697178374994,6.43697172567821,6.43569721125883,46.3588997045238,34,0,0,0,0,0,0,0,0,-2,0,-2,0,0,0,0,0,0,0,0,0,4,0,4,0,0.3152466367713,-0.720413436692506,0.0574902206455467,-0.317476555839727,-0.670157068062827,0.715789473684211,-0.608731466227348,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.872,-0.674,"8:7","147/150","V:L:I:M:F",1.86205820059201,1.05183177238756e-09,0.305188422646507,6.10133957390906,3.55222271070208,11.8555583489231,0.808681605417837,2.90039620895666e-09,8.53754267120101,3.39739251160169,12.3875045168727,9.84592753332283e-12,"lineage2","dr_mutations_pyrazinamide","THR",0,"ERS456976","ERR550933_ERR550932_ERR550934","lineage2.2.1","uz","Nukus","pnca_p.ile133thr","A","E","ILE","IA133","pnca_complex.pdb"
|
|
"I133T","L2","PZA","I","I133",133,"T",1,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",3.05,0.703,-2.788,1.57844,-1.862,-2.56,68,80,-0.739,8,8,3,0.015228426395939,"strand",1.96666666666667,7.9,0.0031622825930717,6.43697178374994,6.43697172567821,6.43569721125883,46.3588997045238,34,0,0,0,0,0,0,0,0,-2,0,-2,0,0,0,0,0,0,0,0,0,4,0,4,0,0.3152466367713,-0.720413436692506,0.0574902206455467,-0.317476555839727,-0.670157068062827,0.715789473684211,-0.608731466227348,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.872,-0.674,"8:7","147/150","V:L:I:M:F",1.86205820059201,1.05183177238756e-09,0.305188422646507,6.10133957390906,3.55222271070208,11.8555583489231,0.808681605417837,2.90039620895666e-09,8.53754267120101,3.39739251160169,12.3875045168727,9.84592753332283e-12,"lineage2","dr_mutations_pyrazinamide","THR",0,"ERS458310","ERR552794_ERR552793","lineage2.2.1","uz","Nukus","pnca_p.ile133thr","A","E","ILE","IA133","pnca_complex.pdb"
|
|
"I133T","L2","PZA","I","I133",133,"T",0,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",3.05,0.703,-2.788,1.57844,-1.862,-2.56,68,80,-0.739,8,8,3,0.015228426395939,"strand",1.96666666666667,7.9,0.0031622825930717,6.43697178374994,6.43697172567821,6.43569721125883,46.3588997045238,34,0,0,0,0,0,0,0,0,-2,0,-2,0,0,0,0,0,0,0,0,0,4,0,4,0,0.3152466367713,-0.720413436692506,0.0574902206455467,-0.317476555839727,-0.670157068062827,0.715789473684211,-0.608731466227348,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.872,-0.674,"8:7","147/150","V:L:I:M:F",1.86205820059201,1.05183177238756e-09,0.305188422646507,6.10133957390906,3.55222271070208,11.8555583489231,0.808681605417837,2.90039620895666e-09,8.53754267120101,3.39739251160169,12.3875045168727,9.84592753332283e-12,"lineage2","dr_mutations_pyrazinamide","THR",0,"ERS458579,SAMEA2535177","ERR553152_ERR553153","lineage2.2.1","uz","Nukus","pnca_p.ile133thr","A","E","ILE","IA133","pnca_complex.pdb"
|
|
"I133T","L2","PZA","I","I133",133,"T",0,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",3.05,0.703,-2.788,1.57844,-1.862,-2.56,68,80,-0.739,8,8,3,0.015228426395939,"strand",1.96666666666667,7.9,0.0031622825930717,6.43697178374994,6.43697172567821,6.43569721125883,46.3588997045238,34,0,0,0,0,0,0,0,0,-2,0,-2,0,0,0,0,0,0,0,0,0,4,0,4,0,0.3152466367713,-0.720413436692506,0.0574902206455467,-0.317476555839727,-0.670157068062827,0.715789473684211,-0.608731466227348,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.872,-0.674,"8:7","147/150","V:L:I:M:F",1.86205820059201,1.05183177238756e-09,0.305188422646507,6.10133957390906,3.55222271070208,11.8555583489231,0.808681605417837,2.90039620895666e-09,8.53754267120101,3.39739251160169,12.3875045168727,9.84592753332283e-12,"lineage2","dr_mutations_pyrazinamide","THR",0,"ERS458740","ERR553364_ERR553365_ERR553363","lineage2.2.1","uz","Nukus","pnca_p.ile133thr","A","E","ILE","IA133","pnca_complex.pdb"
|
|
"I133T","L4","PZA","I","I133",133,"T",1,"XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",3.05,0.703,-2.788,1.57844,-1.862,-2.56,68,80,-0.739,8,8,3,0.015228426395939,"strand",1.96666666666667,7.9,0.0031622825930717,6.43697178374994,6.43697172567821,6.43569721125883,46.3588997045238,34,0,0,0,0,0,0,0,0,-2,0,-2,0,0,0,0,0,0,0,0,0,4,0,4,0,0.3152466367713,-0.720413436692506,0.0574902206455467,-0.317476555839727,-0.670157068062827,0.715789473684211,-0.608731466227348,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.872,-0.674,"8:7","147/150","V:L:I:M:F",1.86205820059201,1.05183177238756e-09,0.305188422646507,6.10133957390906,3.55222271070208,11.8555583489231,0.808681605417837,2.90039620895666e-09,8.53754267120101,3.39739251160169,12.3875045168727,9.84592753332283e-12,"lineage4","dr_mutations_pyrazinamide","THR",0,"ERR1034853","ERR1034853","lineage4.3.4.2","pt","Portugal","pnca_p.ile133thr","A","E","ILE","IA133","pnca_complex.pdb"
|
|
"I133T","L2","PZA","I","I133",133,"T",1,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",3.05,0.703,-2.788,1.57844,-1.862,-2.56,68,80,-0.739,8,8,3,0.015228426395939,"strand",1.96666666666667,7.9,0.0031622825930717,6.43697178374994,6.43697172567821,6.43569721125883,46.3588997045238,34,0,0,0,0,0,0,0,0,-2,0,-2,0,0,0,0,0,0,0,0,0,4,0,4,0,0.3152466367713,-0.720413436692506,0.0574902206455467,-0.317476555839727,-0.670157068062827,0.715789473684211,-0.608731466227348,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.872,-0.674,"8:7","147/150","V:L:I:M:F",1.86205820059201,1.05183177238756e-09,0.305188422646507,6.10133957390906,3.55222271070208,11.8555583489231,0.808681605417837,2.90039620895666e-09,8.53754267120101,3.39739251160169,12.3875045168727,9.84592753332283e-12,"lineage2","dr_mutations_pyrazinamide","THR",0,"ERS458242","ERR552709_ERR552708","lineage2.2.1","uz","Nukus","pnca_p.ile133thr","A","E","ILE","IA133","pnca_complex.pdb"
|
|
"I133T","L2","PZA","I","I133",133,"T",1,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",3.05,0.703,-2.788,1.57844,-1.862,-2.56,68,80,-0.739,8,8,3,0.015228426395939,"strand",1.96666666666667,7.9,0.0031622825930717,6.43697178374994,6.43697172567821,6.43569721125883,46.3588997045238,34,0,0,0,0,0,0,0,0,-2,0,-2,0,0,0,0,0,0,0,0,0,4,0,4,0,0.3152466367713,-0.720413436692506,0.0574902206455467,-0.317476555839727,-0.670157068062827,0.715789473684211,-0.608731466227348,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.872,-0.674,"8:7","147/150","V:L:I:M:F",1.86205820059201,1.05183177238756e-09,0.305188422646507,6.10133957390906,3.55222271070208,11.8555583489231,0.808681605417837,2.90039620895666e-09,8.53754267120101,3.39739251160169,12.3875045168727,9.84592753332283e-12,"lineage2","dr_mutations_pyrazinamide","THR",0,"ERS458340,SAMEA2534938","ERR552833_ERR552834","lineage2.2.1","uz","Nukus","pnca_p.ile133thr","A","E","ILE","IA133","pnca_complex.pdb"
|
|
"I133T","L3","PZA","I","I133",133,"T",0,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",3.05,0.703,-2.788,1.57844,-1.862,-2.56,68,80,-0.739,8,8,3,0.015228426395939,"strand",1.96666666666667,7.9,0.0031622825930717,6.43697178374994,6.43697172567821,6.43569721125883,46.3588997045238,34,0,0,0,0,0,0,0,0,-2,0,-2,0,0,0,0,0,0,0,0,0,4,0,4,0,0.3152466367713,-0.720413436692506,0.0574902206455467,-0.317476555839727,-0.670157068062827,0.715789473684211,-0.608731466227348,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.872,-0.674,"8:7","147/150","V:L:I:M:F",1.86205820059201,1.05183177238756e-09,0.305188422646507,6.10133957390906,3.55222271070208,11.8555583489231,0.808681605417837,2.90039620895666e-09,8.53754267120101,3.39739251160169,12.3875045168727,9.84592753332283e-12,"lineage3","dr_mutations_pyrazinamide","THR",0,"ERR3335760","ERR3335760","lineage3","pk","Pakistan","pnca_p.ile133thr","A","E","ILE","IA133","pnca_complex.pdb"
|
|
"I133T","L4","PZA","I","I133",133,"T",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",3.05,0.703,-2.788,1.57844,-1.862,-2.56,68,80,-0.739,8,8,3,0.015228426395939,"strand",1.96666666666667,7.9,0.0031622825930717,6.43697178374994,6.43697172567821,6.43569721125883,46.3588997045238,34,0,0,0,0,0,0,0,0,-2,0,-2,0,0,0,0,0,0,0,0,0,4,0,4,0,0.3152466367713,-0.720413436692506,0.0574902206455467,-0.317476555839727,-0.670157068062827,0.715789473684211,-0.608731466227348,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.872,-0.674,"8:7","147/150","V:L:I:M:F",1.86205820059201,1.05183177238756e-09,0.305188422646507,6.10133957390906,3.55222271070208,11.8555583489231,0.808681605417837,2.90039620895666e-09,8.53754267120101,3.39739251160169,12.3875045168727,9.84592753332283e-12,"lineage4","dr_mutations_pyrazinamide","THR",0,"ERR3256128","ERR3256128","lineage4.1.1.3","ph","Philippines","pnca_p.ile133thr","A","E","ILE","IA133","pnca_complex.pdb"
|
|
"I133T","L2","PZA","I","I133",133,"T",1,"XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",3.05,0.703,-2.788,1.57844,-1.862,-2.56,68,80,-0.739,8,8,3,0.015228426395939,"strand",1.96666666666667,7.9,0.0031622825930717,6.43697178374994,6.43697172567821,6.43569721125883,46.3588997045238,34,0,0,0,0,0,0,0,0,-2,0,-2,0,0,0,0,0,0,0,0,0,4,0,4,0,0.3152466367713,-0.720413436692506,0.0574902206455467,-0.317476555839727,-0.670157068062827,0.715789473684211,-0.608731466227348,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.872,-0.674,"8:7","147/150","V:L:I:M:F",1.86205820059201,1.05183177238756e-09,0.305188422646507,6.10133957390906,3.55222271070208,11.8555583489231,0.808681605417837,2.90039620895666e-09,8.53754267120101,3.39739251160169,12.3875045168727,9.84592753332283e-12,"lineage2","dr_mutations_pyrazinamide","THR",0,"ERR2516723","ERR2516723","lineage2.2.1","pe","Peru","pnca_p.ile133thr","A","E","ILE","IA133","pnca_complex.pdb"
|
|
"A134D","L4","PZA","A","A134",134,"D",0,"Pre-XDR","OM","hydrophobic","hydrophilic","non-polar","acidic","non-polar","neg",3.047,0.582,-2.98,1.03055,-3.856,-1.13,85,91,-1.111,9,9,10,0.0775193798449612,"loop",1.86666666666667,6.77,7.18700589334483e-05,2.42412778478352,0.0001249735077034,0,1.03410070803344e-29,-24,-34,0,0,-34,0,0,0,0,-2,0,-2,0,0,0,0,0,0,0,0,-2,-4,0,-2,-3,0.260986547085202,-0.770025839793282,0.0375348742342237,-0.657459505541347,-0.295811518324607,0.894736842105263,-0.915156507413509,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.178,-1.094,"9:9","147/150","V:T:S:A",-8.98740878149643,0.940032862253634,119.468044435494,-0.0752285585987736,NA,4692673.510814,0.384555509373631,1,0,0,188.544222231268,0.999999999999997,"lineage4","other_mutations_pyrazinamide","ASP",0,"SRR2100459,SAMN03647632","SRR2100459","lineage4.4.1.1","","","pnca_p.ala134asp","A","-","ALA","AA134","pnca_complex.pdb"
|
|
"A134G","L4","PZA","A","A134",134,"G",NA,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",3.047,-0.378,-1.618,-1.28536,-2.508,-1.88,79,85,-1.111,9,9,10,0.0775193798449612,"loop",1.86666666666667,6.77,NA,NA,NA,NA,NA,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,3,14,-0.0957446808510638,-0.418087855297158,-0.247127585941706,-0.427621483375959,-0.492146596858639,0.831578947368421,-0.915156507413509,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.178,-1.094,"9:9","147/150","V:T:S:A",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage4","other_mutations_pyrazinamide","GLY",0,"ERR3148178","ERR3148178","lineage4.3.3","mx","Mexico","pnca_p.ala134gly","A","-","ALA","AA134","pnca_complex.pdb"
|
|
"A134G","L4","PZA","A","A134",134,"G",NA,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",3.047,-0.378,-1.618,-1.28536,-2.508,-1.88,79,85,-1.111,9,9,10,0.0775193798449612,"loop",1.86666666666667,6.77,NA,NA,NA,NA,NA,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,3,14,-0.0957446808510638,-0.418087855297158,-0.247127585941706,-0.427621483375959,-0.492146596858639,0.831578947368421,-0.915156507413509,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.178,-1.094,"9:9","147/150","V:T:S:A",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage4","other_mutations_pyrazinamide","GLY",0,"ERR1035258","ERR1035258","lineage4.1.2.1","br","Brazil","pnca_p.ala134gly","A","-","ALA","AA134","pnca_complex.pdb"
|
|
"A134G","L4","PZA","A","A134",134,"G",NA,"Pre-MDR","OM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",3.047,-0.378,-1.618,-1.28536,-2.508,-1.88,79,85,-1.111,9,9,10,0.0775193798449612,"loop",1.86666666666667,6.77,NA,NA,NA,NA,NA,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,3,14,-0.0957446808510638,-0.418087855297158,-0.247127585941706,-0.427621483375959,-0.492146596858639,0.831578947368421,-0.915156507413509,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.178,-1.094,"9:9","147/150","V:T:S:A",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage4","other_mutations_pyrazinamide","GLY",0,"ERR2679261","ERR2679261","lineage4.1","","","pnca_p.ala134gly","A","-","ALA","AA134","pnca_complex.pdb"
|
|
"A134G","L4","PZA","A","A134",134,"G",NA,"XDR","OM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",3.047,-0.378,-1.618,-1.28536,-2.508,-1.88,79,85,-1.111,9,9,10,0.0775193798449612,"loop",1.86666666666667,6.77,NA,NA,NA,NA,NA,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,3,14,-0.0957446808510638,-0.418087855297158,-0.247127585941706,-0.427621483375959,-0.492146596858639,0.831578947368421,-0.915156507413509,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.178,-1.094,"9:9","147/150","V:T:S:A",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage4","other_mutations_pyrazinamide","GLY",0,"ERR1035260","ERR1035260","lineage4.1.2.1","br","Brazil","pnca_p.ala134gly","A","-","ALA","AA134","pnca_complex.pdb"
|
|
"A134G","L4","PZA","A","A134",134,"G",NA,"XDR","OM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",3.047,-0.378,-1.618,-1.28536,-2.508,-1.88,79,85,-1.111,9,9,10,0.0775193798449612,"loop",1.86666666666667,6.77,NA,NA,NA,NA,NA,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,3,14,-0.0957446808510638,-0.418087855297158,-0.247127585941706,-0.427621483375959,-0.492146596858639,0.831578947368421,-0.915156507413509,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.178,-1.094,"9:9","147/150","V:T:S:A",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage4","other_mutations_pyrazinamide","GLY",0,"ERR1034895","ERR1034895","lineage4.3.4.2","pt","Portugal","pnca_p.ala134gly","A","-","ALA","AA134","pnca_complex.pdb"
|
|
"A134P","L2","PZA","A","A134",134,"P",1,"MDR","OM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",3.047,0.077,-1.426,-5.2012,-2.503,-0.19,88,91,-1.111,9,9,10,0.0775193798449612,"loop",1.86666666666667,6.77,7.18700589334483e-05,9.70142977291842,188179.92626465,Inf,0.763784339928386,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,-1,-2,-2,0,0,-9,0.0345291479820627,-0.368475452196382,-1,-0.426768968456948,-0.0497382198952879,0.926315789473684,-0.915156507413509,"Stabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.178,-1.094,"9:9","147/150","V:T:S:A",12.1451538387265,0.919026337424237,119.468044436237,0.101660271548252,5.01153666062244e-06,NA,0.986835744238421,0.170978870202674,0.767057556984365,0.124324963210678,Inf,0.382146811758261,"lineage2","other_mutations_pyrazinamide","PRO",0,"SAMEA2535049,ERS458451","ERR552982_ERR552983","lineage2.2.1","uz","Nukus","pnca_p.ala134pro","A","-","ALA","AA134","pnca_complex.pdb"
|
|
"A134P","L2","PZA","A","A134",134,"P",NA,"Pre-XDR","OM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",3.047,0.077,-1.426,-5.2012,-2.503,-0.19,88,91,-1.111,9,9,10,0.0775193798449612,"loop",1.86666666666667,6.77,7.18700589334483e-05,9.70142977291842,188179.92626465,Inf,0.763784339928386,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,-1,-2,-2,0,0,-9,0.0345291479820627,-0.368475452196382,-1,-0.426768968456948,-0.0497382198952879,0.926315789473684,-0.915156507413509,"Stabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.178,-1.094,"9:9","147/150","V:T:S:A",12.1451538387265,0.919026337424237,119.468044436237,0.101660271548252,5.01153666062244e-06,NA,0.986835744238421,0.170978870202674,0.767057556984365,0.124324963210678,Inf,0.382146811758261,"lineage2","other_mutations_pyrazinamide","PRO",0,"SRR8237366","SRR8237366","lineage2.2.1","us","","pnca_p.ala134pro","A","-","ALA","AA134","pnca_complex.pdb"
|
|
"A134T","L1","PZA","A","A134",134,"T",NA,"XDR","OM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",3.047,0.875,-1.925,-0.943073,-1.723,-1.44,61,80,-1.111,9,9,10,0.0775193798449612,"loop",1.86666666666667,6.77,NA,NA,NA,NA,NA,-6,0,0,0,0,0,0,0,0,-2,0,-2,0,0,0,0,0,-2,0,0,-4,-2,0,-2,-3,0.39237668161435,-0.497416020671835,-0.181318349611628,-0.293776641091219,-0.37696335078534,0.642105263157895,-0.915156507413509,"Stabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.178,-1.094,"9:9","147/150","V:T:S:A",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage1","other_mutations_pyrazinamide","THR",0,"SRR7898227","SRR7898227","lineage1.1.2","in","India","pnca_p.ala134thr","A","-","ALA","AA134","pnca_complex.pdb"
|
|
"A134V","L4","PZA","A","A134",134,"V",0,"Other","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",3.047,0.118,-0.414,-1.46184,-1.64,-0.88,74,85,-1.111,9,9,10,0.0775193798449612,"loop",1.86666666666667,6.77,0.0003593502946672,19.4256842105263,19.4256680571767,19.4169790983636,9.87561363723508,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-2,0,-2,-6,-2,0,-2,-3,0.052914798206278,-0.106976744186046,-0.281058217334461,-0.279624893435635,-0.230366492146597,0.778947368421053,-0.915156507413509,"Stabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.178,-1.094,"9:9","147/150","V:T:S:A",2.96659528728018,0.0079500503166053,1.11770528264822,2.65418382943607,2.87215213651462,380.097158975588,1.28837632444196,0.0036816889015929,2.43395291165754,1.92061868691892,951.403114304703,0.0016748373055023,"lineage4","dr_mutations_pyrazinamide","VAL",0,"ERR2513980","ERR2513980","lineage4.8","gb","UK","pnca_p.ala134val","A","-","ALA","AA134","pnca_complex.pdb"
|
|
"A134V","L2","PZA","A","A134",134,"V",1,"MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",3.047,0.118,-0.414,-1.46184,-1.64,-0.88,74,85,-1.111,9,9,10,0.0775193798449612,"loop",1.86666666666667,6.77,0.0003593502946672,19.4256842105263,19.4256680571767,19.4169790983636,9.87561363723508,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-2,0,-2,-6,-2,0,-2,-3,0.052914798206278,-0.106976744186046,-0.281058217334461,-0.279624893435635,-0.230366492146597,0.778947368421053,-0.915156507413509,"Stabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.178,-1.094,"9:9","147/150","V:T:S:A",2.96659528728018,0.0079500503166053,1.11770528264822,2.65418382943607,2.87215213651462,380.097158975588,1.28837632444196,0.0036816889015929,2.43395291165754,1.92061868691892,951.403114304703,0.0016748373055023,"lineage2","dr_mutations_pyrazinamide","VAL",0,"ERR2510716","ERR2510716","lineage2.2.1","it","Italy","pnca_p.ala134val","A","-","ALA","AA134","pnca_complex.pdb"
|
|
"A134V","L2","PZA","A","A134",134,"V",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",3.047,0.118,-0.414,-1.46184,-1.64,-0.88,74,85,-1.111,9,9,10,0.0775193798449612,"loop",1.86666666666667,6.77,0.0003593502946672,19.4256842105263,19.4256680571767,19.4169790983636,9.87561363723508,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-2,0,-2,-6,-2,0,-2,-3,0.052914798206278,-0.106976744186046,-0.281058217334461,-0.279624893435635,-0.230366492146597,0.778947368421053,-0.915156507413509,"Stabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.178,-1.094,"9:9","147/150","V:T:S:A",2.96659528728018,0.0079500503166053,1.11770528264822,2.65418382943607,2.87215213651462,380.097158975588,1.28837632444196,0.0036816889015929,2.43395291165754,1.92061868691892,951.403114304703,0.0016748373055023,"lineage2","dr_mutations_pyrazinamide","VAL",0,"SRR5073810","SRR5073810","lineage2.2.1","vn","Vietnam","pnca_p.ala134val","A","-","ALA","AA134","pnca_complex.pdb"
|
|
"A134V","L2","PZA","A","A134",134,"V",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",3.047,0.118,-0.414,-1.46184,-1.64,-0.88,74,85,-1.111,9,9,10,0.0775193798449612,"loop",1.86666666666667,6.77,0.0003593502946672,19.4256842105263,19.4256680571767,19.4169790983636,9.87561363723508,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-2,0,-2,-6,-2,0,-2,-3,0.052914798206278,-0.106976744186046,-0.281058217334461,-0.279624893435635,-0.230366492146597,0.778947368421053,-0.915156507413509,"Stabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.178,-1.094,"9:9","147/150","V:T:S:A",2.96659528728018,0.0079500503166053,1.11770528264822,2.65418382943607,2.87215213651462,380.097158975588,1.28837632444196,0.0036816889015929,2.43395291165754,1.92061868691892,951.403114304703,0.0016748373055023,"lineage2","dr_mutations_pyrazinamide","VAL",0,"SAMN03653268,SRS936004","SRR2024966","lineage2.2.1","cn","China","pnca_p.ala134val","A","-","ALA","AA134","pnca_complex.pdb"
|
|
"A134V","L2","PZA","A","A134",134,"V",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",3.047,0.118,-0.414,-1.46184,-1.64,-0.88,74,85,-1.111,9,9,10,0.0775193798449612,"loop",1.86666666666667,6.77,0.0003593502946672,19.4256842105263,19.4256680571767,19.4169790983636,9.87561363723508,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-2,0,-2,-6,-2,0,-2,-3,0.052914798206278,-0.106976744186046,-0.281058217334461,-0.279624893435635,-0.230366492146597,0.778947368421053,-0.915156507413509,"Stabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.178,-1.094,"9:9","147/150","V:T:S:A",2.96659528728018,0.0079500503166053,1.11770528264822,2.65418382943607,2.87215213651462,380.097158975588,1.28837632444196,0.0036816889015929,2.43395291165754,1.92061868691892,951.403114304703,0.0016748373055023,"lineage2","dr_mutations_pyrazinamide","VAL",0,"SAMN02350409","SRR1011450_SRR1062820","lineage2.2.1","za","South Africa","pnca_p.ala134val","A","-","ALA","AA134","pnca_complex.pdb"
|
|
"A134V","L4","PZA","A","A134",134,"V",1,"MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",3.047,0.118,-0.414,-1.46184,-1.64,-0.88,74,85,-1.111,9,9,10,0.0775193798449612,"loop",1.86666666666667,6.77,0.0003593502946672,19.4256842105263,19.4256680571767,19.4169790983636,9.87561363723508,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-2,0,-2,-6,-2,0,-2,-3,0.052914798206278,-0.106976744186046,-0.281058217334461,-0.279624893435635,-0.230366492146597,0.778947368421053,-0.915156507413509,"Stabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.178,-1.094,"9:9","147/150","V:T:S:A",2.96659528728018,0.0079500503166053,1.11770528264822,2.65418382943607,2.87215213651462,380.097158975588,1.28837632444196,0.0036816889015929,2.43395291165754,1.92061868691892,951.403114304703,0.0016748373055023,"lineage4","dr_mutations_pyrazinamide","VAL",0,"ERR2516220","ERR2516220","lineage4","be","Belgium","pnca_p.ala134val","A","-","ALA","AA134","pnca_complex.pdb"
|
|
"A134V","L2","PZA","A","A134",134,"V",1,"XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",3.047,0.118,-0.414,-1.46184,-1.64,-0.88,74,85,-1.111,9,9,10,0.0775193798449612,"loop",1.86666666666667,6.77,0.0003593502946672,19.4256842105263,19.4256680571767,19.4169790983636,9.87561363723508,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-2,0,-2,-6,-2,0,-2,-3,0.052914798206278,-0.106976744186046,-0.281058217334461,-0.279624893435635,-0.230366492146597,0.778947368421053,-0.915156507413509,"Stabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.178,-1.094,"9:9","147/150","V:T:S:A",2.96659528728018,0.0079500503166053,1.11770528264822,2.65418382943607,2.87215213651462,380.097158975588,1.28837632444196,0.0036816889015929,2.43395291165754,1.92061868691892,951.403114304703,0.0016748373055023,"lineage2","dr_mutations_pyrazinamide","VAL",0,"1739R-sc-2012-02-21T11:37:11Z-1364767,ERR137275","ERR137275","lineage2.2.1","ru","Russia,Samara","pnca_p.ala134val","A","-","ALA","AA134","pnca_complex.pdb"
|
|
"A134V","L2","PZA","A","A134",134,"V",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",3.047,0.118,-0.414,-1.46184,-1.64,-0.88,74,85,-1.111,9,9,10,0.0775193798449612,"loop",1.86666666666667,6.77,0.0003593502946672,19.4256842105263,19.4256680571767,19.4169790983636,9.87561363723508,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-2,0,-2,-6,-2,0,-2,-3,0.052914798206278,-0.106976744186046,-0.281058217334461,-0.279624893435635,-0.230366492146597,0.778947368421053,-0.915156507413509,"Stabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.178,-1.094,"9:9","147/150","V:T:S:A",2.96659528728018,0.0079500503166053,1.11770528264822,2.65418382943607,2.87215213651462,380.097158975588,1.28837632444196,0.0036816889015929,2.43395291165754,1.92061868691892,951.403114304703,0.0016748373055023,"lineage2","dr_mutations_pyrazinamide","VAL",0,"SRR5073654","SRR5073654","lineage2.2.1","vn","Vietnam","pnca_p.ala134val","A","-","ALA","AA134","pnca_complex.pdb"
|
|
"A134V","L4","PZA","A","A134",134,"V",1,"MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",3.047,0.118,-0.414,-1.46184,-1.64,-0.88,74,85,-1.111,9,9,10,0.0775193798449612,"loop",1.86666666666667,6.77,0.0003593502946672,19.4256842105263,19.4256680571767,19.4169790983636,9.87561363723508,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-2,0,-2,-6,-2,0,-2,-3,0.052914798206278,-0.106976744186046,-0.281058217334461,-0.279624893435635,-0.230366492146597,0.778947368421053,-0.915156507413509,"Stabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.178,-1.094,"9:9","147/150","V:T:S:A",2.96659528728018,0.0079500503166053,1.11770528264822,2.65418382943607,2.87215213651462,380.097158975588,1.28837632444196,0.0036816889015929,2.43395291165754,1.92061868691892,951.403114304703,0.0016748373055023,"lineage4","dr_mutations_pyrazinamide","VAL",0,"ERR2041750","ERR2041750","lineage4.1.2.1","rs","Serbia","pnca_p.ala134val","A","-","ALA","AA134","pnca_complex.pdb"
|
|
"A134V","L2","PZA","A","A134",134,"V",NA,"XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",3.047,0.118,-0.414,-1.46184,-1.64,-0.88,74,85,-1.111,9,9,10,0.0775193798449612,"loop",1.86666666666667,6.77,0.0003593502946672,19.4256842105263,19.4256680571767,19.4169790983636,9.87561363723508,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-2,0,-2,-6,-2,0,-2,-3,0.052914798206278,-0.106976744186046,-0.281058217334461,-0.279624893435635,-0.230366492146597,0.778947368421053,-0.915156507413509,"Stabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.178,-1.094,"9:9","147/150","V:T:S:A",2.96659528728018,0.0079500503166053,1.11770528264822,2.65418382943607,2.87215213651462,380.097158975588,1.28837632444196,0.0036816889015929,2.43395291165754,1.92061868691892,951.403114304703,0.0016748373055023,"lineage2","dr_mutations_pyrazinamide","VAL",0,"SAMN02350410","SRR1062821_SRR1011451","lineage2.2.1","za","South Africa","pnca_p.ala134val","A","-","ALA","AA134","pnca_complex.pdb"
|
|
"T135A","L2","PZA","T","T135",135,"A",NA,"Pre-XDR","OM","hydrophobic","hydrophobic","neutral","non-polar","polar","non-polar",6.021,-1.324,-0.347,0.939971,-1.151,-0.32,72,85,-0.612,7,7,3,0.0174418604651162,"loop",-0.8,5.97,NA,NA,NA,NA,NA,4,0,0,0,0,0,0,0,0,4,0,-2,4,0,0,0,0,4,0,4,2,6,0,6,3,-0.335359675785208,-0.0896640826873385,0.0342357898877469,-0.196248934356351,-0.0837696335078534,0.757894736842105,-0.504118616144975,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","147/150","G:S:M:A:T:L:R:E:Y:F:Q",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage2","other_mutations_pyrazinamide","ALA",0,"SAMN02584663","SRR1166176_SRR1169028","lineage2.2.1","md","Moldova","pnca_p.thr135ala","A","T","THR","TA135","pnca_complex.pdb"
|
|
"T135A","L4","PZA","T","T135",135,"A",NA,"MDR","OM","hydrophobic","hydrophobic","neutral","non-polar","polar","non-polar",6.021,-1.324,-0.347,0.939971,-1.151,-0.32,72,85,-0.612,7,7,3,0.0174418604651162,"loop",-0.8,5.97,NA,NA,NA,NA,NA,4,0,0,0,0,0,0,0,0,4,0,-2,4,0,0,0,0,4,0,4,2,6,0,6,3,-0.335359675785208,-0.0896640826873385,0.0342357898877469,-0.196248934356351,-0.0837696335078534,0.757894736842105,-0.504118616144975,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","147/150","G:S:M:A:T:L:R:E:Y:F:Q",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage4","other_mutations_pyrazinamide","ALA",0,"SAMN02567676","SRR1173361_SRR1173717","lineage4.6.1","ug","Uganda","pnca_p.thr135ala","A","T","THR","TA135","pnca_complex.pdb"
|
|
"T135A","L4","PZA","T","T135",135,"A",NA,"MDR","OM","hydrophobic","hydrophobic","neutral","non-polar","polar","non-polar",6.021,-1.324,-0.347,0.939971,-1.151,-0.32,72,85,-0.612,7,7,3,0.0174418604651162,"loop",-0.8,5.97,NA,NA,NA,NA,NA,4,0,0,0,0,0,0,0,0,4,0,-2,4,0,0,0,0,4,0,4,2,6,0,6,3,-0.335359675785208,-0.0896640826873385,0.0342357898877469,-0.196248934356351,-0.0837696335078534,0.757894736842105,-0.504118616144975,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","147/150","G:S:M:A:T:L:R:E:Y:F:Q",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage4","other_mutations_pyrazinamide","ALA",0,"SRR7517678","SRR7517678","lineage4.4.1.1","cd","DRC","pnca_p.thr135ala","A","T","THR","TA135","pnca_complex.pdb"
|
|
"T135I","L4","PZA","T","T135",135,"I",0,"MDR","OM","hydrophobic","hydrophobic","neutral","non-polar","polar","non-polar",6.021,-1.039,0.442,-0.624872,-0.279,0.66,86,91,-0.612,7,7,3,0.0174418604651162,"loop",-0.8,5.97,7.18700589334483e-05,2.42412778478352,0.0001249735077034,0,1.03410070803344e-29,-10,0,0,0,0,0,0,0,0,4,0,-2,4,0,0,0,0,-3,0,-1,0,2,0,2,-4,-0.263171225937183,0.375850340136054,-0.120139967699762,-0.0475703324808184,0.370786516853933,0.905263157894737,-0.504118616144975,"Destabilising","Stabilising","Stabilising","Destabilising","Stabilising","effect",-0.728,-0.553,"8:7","147/150","G:S:M:A:T:L:R:E:Y:F:Q",-8.9874087814964,0.940032862253633,119.46804443549,-0.0752285585987755,NA,4692673.5108109,0.384555509373631,1,0,0,188.544222231268,0.999999999999997,"lineage4","other_mutations_pyrazinamide","ILE",0,"ERR2516192","ERR2516192","lineage4.2.2","be","Belgium","pnca_p.thr135ile","A","T","THR","TA135","pnca_complex.pdb"
|
|
"T135P","L4","PZA","T","T135",135,"P",1,"MDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",6.021,-1.103,-0.141,4.22994,-2.513,0.5,93,95,-0.612,7,7,3,0.0174418604651162,"loop",-0.8,5.97,0.0019404915912031,127.447513812155,127.447463030391,127.547977311481,114.177692609973,4,0,0,0,0,0,0,0,0,6,2,-2,4,0,0,0,0,0,2,0,0,4,0,4,-2,-0.279381965552178,-0.0364341085271317,0.154063622258321,-0.42847399829497,0.280898876404494,0.978947368421053,-0.504118616144975,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.728,-0.553,"8:7","147/150","G:S:M:A:T:L:R:E:Y:F:Q",4.84770422501703,1.95563371409724e-06,1.01886282652061,4.75795573146171,27.0895053611136,2275.86435679243,2.10533136786968,2.29679039420522e-19,18.638878636844,20.9103539725502,5063.91643152716,1.19139212303841e-26,"lineage4","dr_mutations_pyrazinamide","PRO",0,"SAMN03648845,SRR2101598","SRR2101598","lineage4.1.2.1","","","pnca_p.thr135pro","A","T","THR","TA135","pnca_complex.pdb"
|
|
"T135P","L4","PZA","T","T135",135,"P",NA,"MDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",6.021,-1.103,-0.141,4.22994,-2.513,0.5,93,95,-0.612,7,7,3,0.0174418604651162,"loop",-0.8,5.97,0.0019404915912031,127.447513812155,127.447463030391,127.547977311481,114.177692609973,4,0,0,0,0,0,0,0,0,6,2,-2,4,0,0,0,0,0,2,0,0,4,0,4,-2,-0.279381965552178,-0.0364341085271317,0.154063622258321,-0.42847399829497,0.280898876404494,0.978947368421053,-0.504118616144975,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.728,-0.553,"8:7","147/150","G:S:M:A:T:L:R:E:Y:F:Q",4.84770422501703,1.95563371409724e-06,1.01886282652061,4.75795573146171,27.0895053611136,2275.86435679243,2.10533136786968,2.29679039420522e-19,18.638878636844,20.9103539725502,5063.91643152716,1.19139212303841e-26,"lineage4","dr_mutations_pyrazinamide","PRO",0,"SAMN02403638","SRR1173548_SRR1165318_SRR1167295_SRR1173582","lineage4.1.2.1","za","South Africa","pnca_p.thr135pro","A","T","THR","TA135","pnca_complex.pdb"
|
|
"T135P","L4","PZA","T","T135",135,"P",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",6.021,-1.103,-0.141,4.22994,-2.513,0.5,93,95,-0.612,7,7,3,0.0174418604651162,"loop",-0.8,5.97,0.0019404915912031,127.447513812155,127.447463030391,127.547977311481,114.177692609973,4,0,0,0,0,0,0,0,0,6,2,-2,4,0,0,0,0,0,2,0,0,4,0,4,-2,-0.279381965552178,-0.0364341085271317,0.154063622258321,-0.42847399829497,0.280898876404494,0.978947368421053,-0.504118616144975,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.728,-0.553,"8:7","147/150","G:S:M:A:T:L:R:E:Y:F:Q",4.84770422501703,1.95563371409724e-06,1.01886282652061,4.75795573146171,27.0895053611136,2275.86435679243,2.10533136786968,2.29679039420522e-19,18.638878636844,20.9103539725502,5063.91643152716,1.19139212303841e-26,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR2515335","ERR2515335","lineage4.1.2.1","za","South Africa","pnca_p.thr135pro","A","T","THR","TA135","pnca_complex.pdb"
|
|
"T135P","L2","PZA","T","T135",135,"P",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",6.021,-1.103,-0.141,4.22994,-2.513,0.5,93,95,-0.612,7,7,3,0.0174418604651162,"loop",-0.8,5.97,0.0019404915912031,127.447513812155,127.447463030391,127.547977311481,114.177692609973,4,0,0,0,0,0,0,0,0,6,2,-2,4,0,0,0,0,0,2,0,0,4,0,4,-2,-0.279381965552178,-0.0364341085271317,0.154063622258321,-0.42847399829497,0.280898876404494,0.978947368421053,-0.504118616144975,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.728,-0.553,"8:7","147/150","G:S:M:A:T:L:R:E:Y:F:Q",4.84770422501703,1.95563371409724e-06,1.01886282652061,4.75795573146171,27.0895053611136,2275.86435679243,2.10533136786968,2.29679039420522e-19,18.638878636844,20.9103539725502,5063.91643152716,1.19139212303841e-26,"lineage2","dr_mutations_pyrazinamide","PRO",0,"SAMN02360561","SRR1013563_SRR1013564_SRR1048864_SRR1048863","lineage2.2.2","kr","South Korea","pnca_p.thr135pro","A","T","THR","TA135","pnca_complex.pdb"
|
|
"T135P","L2","PZA","T","T135",135,"P",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",6.021,-1.103,-0.141,4.22994,-2.513,0.5,93,95,-0.612,7,7,3,0.0174418604651162,"loop",-0.8,5.97,0.0019404915912031,127.447513812155,127.447463030391,127.547977311481,114.177692609973,4,0,0,0,0,0,0,0,0,6,2,-2,4,0,0,0,0,0,2,0,0,4,0,4,-2,-0.279381965552178,-0.0364341085271317,0.154063622258321,-0.42847399829497,0.280898876404494,0.978947368421053,-0.504118616144975,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.728,-0.553,"8:7","147/150","G:S:M:A:T:L:R:E:Y:F:Q",4.84770422501703,1.95563371409724e-06,1.01886282652061,4.75795573146171,27.0895053611136,2275.86435679243,2.10533136786968,2.29679039420522e-19,18.638878636844,20.9103539725502,5063.91643152716,1.19139212303841e-26,"lineage2","dr_mutations_pyrazinamide","PRO",0,"SRR6398011","SRR6398011","lineage2.2.1","ca","Canada","pnca_p.thr135pro","A","T","THR","TA135","pnca_complex.pdb"
|
|
"T135P","L2","PZA","T","T135",135,"P",1,"XDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",6.021,-1.103,-0.141,4.22994,-2.513,0.5,93,95,-0.612,7,7,3,0.0174418604651162,"loop",-0.8,5.97,0.0019404915912031,127.447513812155,127.447463030391,127.547977311481,114.177692609973,4,0,0,0,0,0,0,0,0,6,2,-2,4,0,0,0,0,0,2,0,0,4,0,4,-2,-0.279381965552178,-0.0364341085271317,0.154063622258321,-0.42847399829497,0.280898876404494,0.978947368421053,-0.504118616144975,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.728,-0.553,"8:7","147/150","G:S:M:A:T:L:R:E:Y:F:Q",4.84770422501703,1.95563371409724e-06,1.01886282652061,4.75795573146171,27.0895053611136,2275.86435679243,2.10533136786968,2.29679039420522e-19,18.638878636844,20.9103539725502,5063.91643152716,1.19139212303841e-26,"lineage2","dr_mutations_pyrazinamide","PRO",0,"ERR158616,0358Q-sc-2012-04-10T09:16:42Z-1397828","ERR158616","lineage2.2.1","ru","Russia,Samara","pnca_p.thr135pro","A","T","THR","TA135","pnca_complex.pdb"
|
|
"T135P","L4","PZA","T","T135",135,"P",1,"MDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",6.021,-1.103,-0.141,4.22994,-2.513,0.5,93,95,-0.612,7,7,3,0.0174418604651162,"loop",-0.8,5.97,0.0019404915912031,127.447513812155,127.447463030391,127.547977311481,114.177692609973,4,0,0,0,0,0,0,0,0,6,2,-2,4,0,0,0,0,0,2,0,0,4,0,4,-2,-0.279381965552178,-0.0364341085271317,0.154063622258321,-0.42847399829497,0.280898876404494,0.978947368421053,-0.504118616144975,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.728,-0.553,"8:7","147/150","G:S:M:A:T:L:R:E:Y:F:Q",4.84770422501703,1.95563371409724e-06,1.01886282652061,4.75795573146171,27.0895053611136,2275.86435679243,2.10533136786968,2.29679039420522e-19,18.638878636844,20.9103539725502,5063.91643152716,1.19139212303841e-26,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR551537","ERR551537","lineage4.3;lineage4.1.2.1","sz","Swaziland","pnca_p.thr135pro","A","T","THR","TA135","pnca_complex.pdb"
|
|
"T135P","L4","PZA","T","T135",135,"P",NA,"MDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",6.021,-1.103,-0.141,4.22994,-2.513,0.5,93,95,-0.612,7,7,3,0.0174418604651162,"loop",-0.8,5.97,0.0019404915912031,127.447513812155,127.447463030391,127.547977311481,114.177692609973,4,0,0,0,0,0,0,0,0,6,2,-2,4,0,0,0,0,0,2,0,0,4,0,4,-2,-0.279381965552178,-0.0364341085271317,0.154063622258321,-0.42847399829497,0.280898876404494,0.978947368421053,-0.504118616144975,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.728,-0.553,"8:7","147/150","G:S:M:A:T:L:R:E:Y:F:Q",4.84770422501703,1.95563371409724e-06,1.01886282652061,4.75795573146171,27.0895053611136,2275.86435679243,2.10533136786968,2.29679039420522e-19,18.638878636844,20.9103539725502,5063.91643152716,1.19139212303841e-26,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR751521","ERR751521","lineage4","pe","","pnca_p.thr135pro","A","T","THR","TA135","pnca_complex.pdb"
|
|
"T135P","L2","PZA","T","T135",135,"P",NA,"MDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",6.021,-1.103,-0.141,4.22994,-2.513,0.5,93,95,-0.612,7,7,3,0.0174418604651162,"loop",-0.8,5.97,0.0019404915912031,127.447513812155,127.447463030391,127.547977311481,114.177692609973,4,0,0,0,0,0,0,0,0,6,2,-2,4,0,0,0,0,0,2,0,0,4,0,4,-2,-0.279381965552178,-0.0364341085271317,0.154063622258321,-0.42847399829497,0.280898876404494,0.978947368421053,-0.504118616144975,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.728,-0.553,"8:7","147/150","G:S:M:A:T:L:R:E:Y:F:Q",4.84770422501703,1.95563371409724e-06,1.01886282652061,4.75795573146171,27.0895053611136,2275.86435679243,2.10533136786968,2.29679039420522e-19,18.638878636844,20.9103539725502,5063.91643152716,1.19139212303841e-26,"lineage2","dr_mutations_pyrazinamide","PRO",0,"SRR6079935","SRR6079935","lineage2.2.1.1","au","","pnca_p.thr135pro","A","T","THR","TA135","pnca_complex.pdb"
|
|
"T135P","L2","PZA","T","T135",135,"P",1,"XDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",6.021,-1.103,-0.141,4.22994,-2.513,0.5,93,95,-0.612,7,7,3,0.0174418604651162,"loop",-0.8,5.97,0.0019404915912031,127.447513812155,127.447463030391,127.547977311481,114.177692609973,4,0,0,0,0,0,0,0,0,6,2,-2,4,0,0,0,0,0,2,0,0,4,0,4,-2,-0.279381965552178,-0.0364341085271317,0.154063622258321,-0.42847399829497,0.280898876404494,0.978947368421053,-0.504118616144975,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.728,-0.553,"8:7","147/150","G:S:M:A:T:L:R:E:Y:F:Q",4.84770422501703,1.95563371409724e-06,1.01886282652061,4.75795573146171,27.0895053611136,2275.86435679243,2.10533136786968,2.29679039420522e-19,18.638878636844,20.9103539725502,5063.91643152716,1.19139212303841e-26,"lineage2","dr_mutations_pyrazinamide","PRO",0,"ERR1873484","ERR1873484","lineage2.2.1","za","South Africa","pnca_p.thr135pro","A","T","THR","TA135","pnca_complex.pdb"
|
|
"T135P","L2","PZA","T","T135",135,"P",NA,"XDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",6.021,-1.103,-0.141,4.22994,-2.513,0.5,93,95,-0.612,7,7,3,0.0174418604651162,"loop",-0.8,5.97,0.0019404915912031,127.447513812155,127.447463030391,127.547977311481,114.177692609973,4,0,0,0,0,0,0,0,0,6,2,-2,4,0,0,0,0,0,2,0,0,4,0,4,-2,-0.279381965552178,-0.0364341085271317,0.154063622258321,-0.42847399829497,0.280898876404494,0.978947368421053,-0.504118616144975,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.728,-0.553,"8:7","147/150","G:S:M:A:T:L:R:E:Y:F:Q",4.84770422501703,1.95563371409724e-06,1.01886282652061,4.75795573146171,27.0895053611136,2275.86435679243,2.10533136786968,2.29679039420522e-19,18.638878636844,20.9103539725502,5063.91643152716,1.19139212303841e-26,"lineage2","dr_mutations_pyrazinamide","PRO",0,"1358C-sc-2012-02-21T11:36:32Z-1364709,ERR137217","ERR137217","lineage2.2.1","ru","Russia","pnca_p.thr135pro","A","T","THR","TA135","pnca_complex.pdb"
|
|
"T135P","L4","PZA","T","T135",135,"P",1,"MDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",6.021,-1.103,-0.141,4.22994,-2.513,0.5,93,95,-0.612,7,7,3,0.0174418604651162,"loop",-0.8,5.97,0.0019404915912031,127.447513812155,127.447463030391,127.547977311481,114.177692609973,4,0,0,0,0,0,0,0,0,6,2,-2,4,0,0,0,0,0,2,0,0,4,0,4,-2,-0.279381965552178,-0.0364341085271317,0.154063622258321,-0.42847399829497,0.280898876404494,0.978947368421053,-0.504118616144975,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.728,-0.553,"8:7","147/150","G:S:M:A:T:L:R:E:Y:F:Q",4.84770422501703,1.95563371409724e-06,1.01886282652061,4.75795573146171,27.0895053611136,2275.86435679243,2.10533136786968,2.29679039420522e-19,18.638878636844,20.9103539725502,5063.91643152716,1.19139212303841e-26,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR2516458","ERR2516458","lineage4","pe","Peru","pnca_p.thr135pro","A","T","THR","TA135","pnca_complex.pdb"
|
|
"T135P","L2","PZA","T","T135",135,"P",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",6.021,-1.103,-0.141,4.22994,-2.513,0.5,93,95,-0.612,7,7,3,0.0174418604651162,"loop",-0.8,5.97,0.0019404915912031,127.447513812155,127.447463030391,127.547977311481,114.177692609973,4,0,0,0,0,0,0,0,0,6,2,-2,4,0,0,0,0,0,2,0,0,4,0,4,-2,-0.279381965552178,-0.0364341085271317,0.154063622258321,-0.42847399829497,0.280898876404494,0.978947368421053,-0.504118616144975,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.728,-0.553,"8:7","147/150","G:S:M:A:T:L:R:E:Y:F:Q",4.84770422501703,1.95563371409724e-06,1.01886282652061,4.75795573146171,27.0895053611136,2275.86435679243,2.10533136786968,2.29679039420522e-19,18.638878636844,20.9103539725502,5063.91643152716,1.19139212303841e-26,"lineage2","dr_mutations_pyrazinamide","PRO",0,"SAMN02360591","SRR1049007_SRR1049006_SRR1013621_SRR1013622","lineage2.2.2","kr","South Korea","pnca_p.thr135pro","A","T","THR","TA135","pnca_complex.pdb"
|
|
"T135P","L4","PZA","T","T135",135,"P",1,"MDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",6.021,-1.103,-0.141,4.22994,-2.513,0.5,93,95,-0.612,7,7,3,0.0174418604651162,"loop",-0.8,5.97,0.0019404915912031,127.447513812155,127.447463030391,127.547977311481,114.177692609973,4,0,0,0,0,0,0,0,0,6,2,-2,4,0,0,0,0,0,2,0,0,4,0,4,-2,-0.279381965552178,-0.0364341085271317,0.154063622258321,-0.42847399829497,0.280898876404494,0.978947368421053,-0.504118616144975,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.728,-0.553,"8:7","147/150","G:S:M:A:T:L:R:E:Y:F:Q",4.84770422501703,1.95563371409724e-06,1.01886282652061,4.75795573146171,27.0895053611136,2275.86435679243,2.10533136786968,2.29679039420522e-19,18.638878636844,20.9103539725502,5063.91643152716,1.19139212303841e-26,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR2515554","ERR2515554","lineage4.1.2.1","za","South Africa","pnca_p.thr135pro","A","T","THR","TA135","pnca_complex.pdb"
|
|
"T135P","L4","PZA","T","T135",135,"P",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",6.021,-1.103,-0.141,4.22994,-2.513,0.5,93,95,-0.612,7,7,3,0.0174418604651162,"loop",-0.8,5.97,0.0019404915912031,127.447513812155,127.447463030391,127.547977311481,114.177692609973,4,0,0,0,0,0,0,0,0,6,2,-2,4,0,0,0,0,0,2,0,0,4,0,4,-2,-0.279381965552178,-0.0364341085271317,0.154063622258321,-0.42847399829497,0.280898876404494,0.978947368421053,-0.504118616144975,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.728,-0.553,"8:7","147/150","G:S:M:A:T:L:R:E:Y:F:Q",4.84770422501703,1.95563371409724e-06,1.01886282652061,4.75795573146171,27.0895053611136,2275.86435679243,2.10533136786968,2.29679039420522e-19,18.638878636844,20.9103539725502,5063.91643152716,1.19139212303841e-26,"lineage4","dr_mutations_pyrazinamide","PRO",0,"SAMN02231154","SRR1162480_SRR1162773_SRR1103621","lineage4.1","ml","Mali","pnca_p.thr135pro","A","T","THR","TA135","pnca_complex.pdb"
|
|
"T135P","L3","PZA","T","T135",135,"P",1,"MDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",6.021,-1.103,-0.141,4.22994,-2.513,0.5,93,95,-0.612,7,7,3,0.0174418604651162,"loop",-0.8,5.97,0.0019404915912031,127.447513812155,127.447463030391,127.547977311481,114.177692609973,4,0,0,0,0,0,0,0,0,6,2,-2,4,0,0,0,0,0,2,0,0,4,0,4,-2,-0.279381965552178,-0.0364341085271317,0.154063622258321,-0.42847399829497,0.280898876404494,0.978947368421053,-0.504118616144975,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.728,-0.553,"8:7","147/150","G:S:M:A:T:L:R:E:Y:F:Q",4.84770422501703,1.95563371409724e-06,1.01886282652061,4.75795573146171,27.0895053611136,2275.86435679243,2.10533136786968,2.29679039420522e-19,18.638878636844,20.9103539725502,5063.91643152716,1.19139212303841e-26,"lineage3","dr_mutations_pyrazinamide","PRO",0,"ERR2516361","ERR2516361","lineage3.1.1","be","Belgium","pnca_p.thr135pro","A","T","THR","TA135","pnca_complex.pdb"
|
|
"T135P","L2","PZA","T","T135",135,"P",1,"XDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",6.021,-1.103,-0.141,4.22994,-2.513,0.5,93,95,-0.612,7,7,3,0.0174418604651162,"loop",-0.8,5.97,0.0019404915912031,127.447513812155,127.447463030391,127.547977311481,114.177692609973,4,0,0,0,0,0,0,0,0,6,2,-2,4,0,0,0,0,0,2,0,0,4,0,4,-2,-0.279381965552178,-0.0364341085271317,0.154063622258321,-0.42847399829497,0.280898876404494,0.978947368421053,-0.504118616144975,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.728,-0.553,"8:7","147/150","G:S:M:A:T:L:R:E:Y:F:Q",4.84770422501703,1.95563371409724e-06,1.01886282652061,4.75795573146171,27.0895053611136,2275.86435679243,2.10533136786968,2.29679039420522e-19,18.638878636844,20.9103539725502,5063.91643152716,1.19139212303841e-26,"lineage2","dr_mutations_pyrazinamide","PRO",0,"1837Y-sc-2012-02-21T11:37:40Z-1364804,ERR144567","ERR144567","lineage2.2.1","ru","Russia,Samara","pnca_p.thr135pro","A","T","THR","TA135","pnca_complex.pdb"
|
|
"T135P","L4","PZA","T","T135",135,"P",NA,"MDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",6.021,-1.103,-0.141,4.22994,-2.513,0.5,93,95,-0.612,7,7,3,0.0174418604651162,"loop",-0.8,5.97,0.0019404915912031,127.447513812155,127.447463030391,127.547977311481,114.177692609973,4,0,0,0,0,0,0,0,0,6,2,-2,4,0,0,0,0,0,2,0,0,4,0,4,-2,-0.279381965552178,-0.0364341085271317,0.154063622258321,-0.42847399829497,0.280898876404494,0.978947368421053,-0.504118616144975,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.728,-0.553,"8:7","147/150","G:S:M:A:T:L:R:E:Y:F:Q",4.84770422501703,1.95563371409724e-06,1.01886282652061,4.75795573146171,27.0895053611136,2275.86435679243,2.10533136786968,2.29679039420522e-19,18.638878636844,20.9103539725502,5063.91643152716,1.19139212303841e-26,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR751478","ERR751478","lineage4","pe","","pnca_p.thr135pro","A","T","THR","TA135","pnca_complex.pdb"
|
|
"T135P","L2","PZA","T","T135",135,"P",NA,"XDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",6.021,-1.103,-0.141,4.22994,-2.513,0.5,93,95,-0.612,7,7,3,0.0174418604651162,"loop",-0.8,5.97,0.0019404915912031,127.447513812155,127.447463030391,127.547977311481,114.177692609973,4,0,0,0,0,0,0,0,0,6,2,-2,4,0,0,0,0,0,2,0,0,4,0,4,-2,-0.279381965552178,-0.0364341085271317,0.154063622258321,-0.42847399829497,0.280898876404494,0.978947368421053,-0.504118616144975,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.728,-0.553,"8:7","147/150","G:S:M:A:T:L:R:E:Y:F:Q",4.84770422501703,1.95563371409724e-06,1.01886282652061,4.75795573146171,27.0895053611136,2275.86435679243,2.10533136786968,2.29679039420522e-19,18.638878636844,20.9103539725502,5063.91643152716,1.19139212303841e-26,"lineage2","dr_mutations_pyrazinamide","PRO",0,"SAMN02398696","SRR1047982_SRR1144813","lineage2.2.2","kr","South Korea","pnca_p.thr135pro","A","T","THR","TA135","pnca_complex.pdb"
|
|
"T135P","L4","PZA","T","T135",135,"P",1,"MDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",6.021,-1.103,-0.141,4.22994,-2.513,0.5,93,95,-0.612,7,7,3,0.0174418604651162,"loop",-0.8,5.97,0.0019404915912031,127.447513812155,127.447463030391,127.547977311481,114.177692609973,4,0,0,0,0,0,0,0,0,6,2,-2,4,0,0,0,0,0,2,0,0,4,0,4,-2,-0.279381965552178,-0.0364341085271317,0.154063622258321,-0.42847399829497,0.280898876404494,0.978947368421053,-0.504118616144975,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.728,-0.553,"8:7","147/150","G:S:M:A:T:L:R:E:Y:F:Q",4.84770422501703,1.95563371409724e-06,1.01886282652061,4.75795573146171,27.0895053611136,2275.86435679243,2.10533136786968,2.29679039420522e-19,18.638878636844,20.9103539725502,5063.91643152716,1.19139212303841e-26,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR2515246","ERR2515246","lineage4.1.2.1","za","South Africa","pnca_p.thr135pro","A","T","THR","TA135","pnca_complex.pdb"
|
|
"T135P","L2","PZA","T","T135",135,"P",NA,"MDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",6.021,-1.103,-0.141,4.22994,-2.513,0.5,93,95,-0.612,7,7,3,0.0174418604651162,"loop",-0.8,5.97,0.0019404915912031,127.447513812155,127.447463030391,127.547977311481,114.177692609973,4,0,0,0,0,0,0,0,0,6,2,-2,4,0,0,0,0,0,2,0,0,4,0,4,-2,-0.279381965552178,-0.0364341085271317,0.154063622258321,-0.42847399829497,0.280898876404494,0.978947368421053,-0.504118616144975,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.728,-0.553,"8:7","147/150","G:S:M:A:T:L:R:E:Y:F:Q",4.84770422501703,1.95563371409724e-06,1.01886282652061,4.75795573146171,27.0895053611136,2275.86435679243,2.10533136786968,2.29679039420522e-19,18.638878636844,20.9103539725502,5063.91643152716,1.19139212303841e-26,"lineage2","dr_mutations_pyrazinamide","PRO",0,"SAMN07236405,SRR5709873","SRR5709873","lineage2.2.1","th","Thailand","pnca_p.thr135pro","A","T","THR","TA135","pnca_complex.pdb"
|
|
"T135P","L2","PZA","T","T135",135,"P",NA,"XDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",6.021,-1.103,-0.141,4.22994,-2.513,0.5,93,95,-0.612,7,7,3,0.0174418604651162,"loop",-0.8,5.97,0.0019404915912031,127.447513812155,127.447463030391,127.547977311481,114.177692609973,4,0,0,0,0,0,0,0,0,6,2,-2,4,0,0,0,0,0,2,0,0,4,0,4,-2,-0.279381965552178,-0.0364341085271317,0.154063622258321,-0.42847399829497,0.280898876404494,0.978947368421053,-0.504118616144975,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.728,-0.553,"8:7","147/150","G:S:M:A:T:L:R:E:Y:F:Q",4.84770422501703,1.95563371409724e-06,1.01886282652061,4.75795573146171,27.0895053611136,2275.86435679243,2.10533136786968,2.29679039420522e-19,18.638878636844,20.9103539725502,5063.91643152716,1.19139212303841e-26,"lineage2","dr_mutations_pyrazinamide","PRO",0,"SAMN02398711","SRR1144790_SRR1047997","lineage2.2.2","kr","South Korea","pnca_p.thr135pro","A","T","THR","TA135","pnca_complex.pdb"
|
|
"T135P","L2","PZA","T","T135",135,"P",1,"MDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",6.021,-1.103,-0.141,4.22994,-2.513,0.5,93,95,-0.612,7,7,3,0.0174418604651162,"loop",-0.8,5.97,0.0019404915912031,127.447513812155,127.447463030391,127.547977311481,114.177692609973,4,0,0,0,0,0,0,0,0,6,2,-2,4,0,0,0,0,0,2,0,0,4,0,4,-2,-0.279381965552178,-0.0364341085271317,0.154063622258321,-0.42847399829497,0.280898876404494,0.978947368421053,-0.504118616144975,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.728,-0.553,"8:7","147/150","G:S:M:A:T:L:R:E:Y:F:Q",4.84770422501703,1.95563371409724e-06,1.01886282652061,4.75795573146171,27.0895053611136,2275.86435679243,2.10533136786968,2.29679039420522e-19,18.638878636844,20.9103539725502,5063.91643152716,1.19139212303841e-26,"lineage2","dr_mutations_pyrazinamide","PRO",0,"14MT_11620","SRR5525987","lineage2.2.1.1","pg","","pnca_p.thr135pro","A","T","THR","TA135","pnca_complex.pdb"
|
|
"T135P","L4","PZA","T","T135",135,"P",NA,"MDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",6.021,-1.103,-0.141,4.22994,-2.513,0.5,93,95,-0.612,7,7,3,0.0174418604651162,"loop",-0.8,5.97,0.0019404915912031,127.447513812155,127.447463030391,127.547977311481,114.177692609973,4,0,0,0,0,0,0,0,0,6,2,-2,4,0,0,0,0,0,2,0,0,4,0,4,-2,-0.279381965552178,-0.0364341085271317,0.154063622258321,-0.42847399829497,0.280898876404494,0.978947368421053,-0.504118616144975,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.728,-0.553,"8:7","147/150","G:S:M:A:T:L:R:E:Y:F:Q",4.84770422501703,1.95563371409724e-06,1.01886282652061,4.75795573146171,27.0895053611136,2275.86435679243,2.10533136786968,2.29679039420522e-19,18.638878636844,20.9103539725502,5063.91643152716,1.19139212303841e-26,"lineage4","dr_mutations_pyrazinamide","PRO",0,"NG9","ERR1679656","lineage4.6.2.2","ng","Nigeria","pnca_p.thr135pro","A","T","THR","TA135","pnca_complex.pdb"
|
|
"T135P","L4","PZA","T","T135",135,"P",1,"MDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",6.021,-1.103,-0.141,4.22994,-2.513,0.5,93,95,-0.612,7,7,3,0.0174418604651162,"loop",-0.8,5.97,0.0019404915912031,127.447513812155,127.447463030391,127.547977311481,114.177692609973,4,0,0,0,0,0,0,0,0,6,2,-2,4,0,0,0,0,0,2,0,0,4,0,4,-2,-0.279381965552178,-0.0364341085271317,0.154063622258321,-0.42847399829497,0.280898876404494,0.978947368421053,-0.504118616144975,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.728,-0.553,"8:7","147/150","G:S:M:A:T:L:R:E:Y:F:Q",4.84770422501703,1.95563371409724e-06,1.01886282652061,4.75795573146171,27.0895053611136,2275.86435679243,2.10533136786968,2.29679039420522e-19,18.638878636844,20.9103539725502,5063.91643152716,1.19139212303841e-26,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR1034737","ERR1034737","lineage4","pe","Peru","pnca_p.thr135pro","A","T","THR","TA135","pnca_complex.pdb"
|
|
"T135P","L2","PZA","T","T135",135,"P",NA,"XDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",6.021,-1.103,-0.141,4.22994,-2.513,0.5,93,95,-0.612,7,7,3,0.0174418604651162,"loop",-0.8,5.97,0.0019404915912031,127.447513812155,127.447463030391,127.547977311481,114.177692609973,4,0,0,0,0,0,0,0,0,6,2,-2,4,0,0,0,0,0,2,0,0,4,0,4,-2,-0.279381965552178,-0.0364341085271317,0.154063622258321,-0.42847399829497,0.280898876404494,0.978947368421053,-0.504118616144975,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.728,-0.553,"8:7","147/150","G:S:M:A:T:L:R:E:Y:F:Q",4.84770422501703,1.95563371409724e-06,1.01886282652061,4.75795573146171,27.0895053611136,2275.86435679243,2.10533136786968,2.29679039420522e-19,18.638878636844,20.9103539725502,5063.91643152716,1.19139212303841e-26,"lineage2","dr_mutations_pyrazinamide","PRO",0,"SAMN02398704","SRR1047990_SRR1144749","lineage2.2.2","kr","South Korea","pnca_p.thr135pro","A","T","THR","TA135","pnca_complex.pdb"
|
|
"T135P","L4","PZA","T","T135",135,"P",NA,"MDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",6.021,-1.103,-0.141,4.22994,-2.513,0.5,93,95,-0.612,7,7,3,0.0174418604651162,"loop",-0.8,5.97,0.0019404915912031,127.447513812155,127.447463030391,127.547977311481,114.177692609973,4,0,0,0,0,0,0,0,0,6,2,-2,4,0,0,0,0,0,2,0,0,4,0,4,-2,-0.279381965552178,-0.0364341085271317,0.154063622258321,-0.42847399829497,0.280898876404494,0.978947368421053,-0.504118616144975,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.728,-0.553,"8:7","147/150","G:S:M:A:T:L:R:E:Y:F:Q",4.84770422501703,1.95563371409724e-06,1.01886282652061,4.75795573146171,27.0895053611136,2275.86435679243,2.10533136786968,2.29679039420522e-19,18.638878636844,20.9103539725502,5063.91643152716,1.19139212303841e-26,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR1034755","ERR1034755","lineage4","pe","Peru","pnca_p.thr135pro","A","T","THR","TA135","pnca_complex.pdb"
|
|
"T135P","L2","PZA","T","T135",135,"P",NA,"XDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",6.021,-1.103,-0.141,4.22994,-2.513,0.5,93,95,-0.612,7,7,3,0.0174418604651162,"loop",-0.8,5.97,0.0019404915912031,127.447513812155,127.447463030391,127.547977311481,114.177692609973,4,0,0,0,0,0,0,0,0,6,2,-2,4,0,0,0,0,0,2,0,0,4,0,4,-2,-0.279381965552178,-0.0364341085271317,0.154063622258321,-0.42847399829497,0.280898876404494,0.978947368421053,-0.504118616144975,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.728,-0.553,"8:7","147/150","G:S:M:A:T:L:R:E:Y:F:Q",4.84770422501703,1.95563371409724e-06,1.01886282652061,4.75795573146171,27.0895053611136,2275.86435679243,2.10533136786968,2.29679039420522e-19,18.638878636844,20.9103539725502,5063.91643152716,1.19139212303841e-26,"lineage2","dr_mutations_pyrazinamide","PRO",0,"SAMN02398698","SRR1047984_SRR1144807","lineage2.2.2","kr","South Korea","pnca_p.thr135pro","A","T","THR","TA135","pnca_complex.pdb"
|
|
"T135P","L4","PZA","T","T135",135,"P",NA,"MDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",6.021,-1.103,-0.141,4.22994,-2.513,0.5,93,95,-0.612,7,7,3,0.0174418604651162,"loop",-0.8,5.97,0.0019404915912031,127.447513812155,127.447463030391,127.547977311481,114.177692609973,4,0,0,0,0,0,0,0,0,6,2,-2,4,0,0,0,0,0,2,0,0,4,0,4,-2,-0.279381965552178,-0.0364341085271317,0.154063622258321,-0.42847399829497,0.280898876404494,0.978947368421053,-0.504118616144975,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.728,-0.553,"8:7","147/150","G:S:M:A:T:L:R:E:Y:F:Q",4.84770422501703,1.95563371409724e-06,1.01886282652061,4.75795573146171,27.0895053611136,2275.86435679243,2.10533136786968,2.29679039420522e-19,18.638878636844,20.9103539725502,5063.91643152716,1.19139212303841e-26,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR2510175","ERR2510175","lineage4","pe","Peru","pnca_p.thr135pro","A","T","THR","TA135","pnca_complex.pdb"
|
|
"T135P","L2","PZA","T","T135",135,"P",1,"XDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",6.021,-1.103,-0.141,4.22994,-2.513,0.5,93,95,-0.612,7,7,3,0.0174418604651162,"loop",-0.8,5.97,0.0019404915912031,127.447513812155,127.447463030391,127.547977311481,114.177692609973,4,0,0,0,0,0,0,0,0,6,2,-2,4,0,0,0,0,0,2,0,0,4,0,4,-2,-0.279381965552178,-0.0364341085271317,0.154063622258321,-0.42847399829497,0.280898876404494,0.978947368421053,-0.504118616144975,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.728,-0.553,"8:7","147/150","G:S:M:A:T:L:R:E:Y:F:Q",4.84770422501703,1.95563371409724e-06,1.01886282652061,4.75795573146171,27.0895053611136,2275.86435679243,2.10533136786968,2.29679039420522e-19,18.638878636844,20.9103539725502,5063.91643152716,1.19139212303841e-26,"lineage2","dr_mutations_pyrazinamide","PRO",0,"ERR2510654","ERR2510654","lineage2.2.1","it","Italy","pnca_p.thr135pro","A","T","THR","TA135","pnca_complex.pdb"
|
|
"T135P","L2","PZA","T","T135",135,"P",1,"XDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",6.021,-1.103,-0.141,4.22994,-2.513,0.5,93,95,-0.612,7,7,3,0.0174418604651162,"loop",-0.8,5.97,0.0019404915912031,127.447513812155,127.447463030391,127.547977311481,114.177692609973,4,0,0,0,0,0,0,0,0,6,2,-2,4,0,0,0,0,0,2,0,0,4,0,4,-2,-0.279381965552178,-0.0364341085271317,0.154063622258321,-0.42847399829497,0.280898876404494,0.978947368421053,-0.504118616144975,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.728,-0.553,"8:7","147/150","G:S:M:A:T:L:R:E:Y:F:Q",4.84770422501703,1.95563371409724e-06,1.01886282652061,4.75795573146171,27.0895053611136,2275.86435679243,2.10533136786968,2.29679039420522e-19,18.638878636844,20.9103539725502,5063.91643152716,1.19139212303841e-26,"lineage2","dr_mutations_pyrazinamide","PRO",0,"ETB0009","SRR6256977","lineage2.2.1","ru","Russia:Kaliningrad","pnca_p.thr135pro","A","T","THR","TA135","pnca_complex.pdb"
|
|
"T135P","L2","PZA","T","T135",135,"P",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",6.021,-1.103,-0.141,4.22994,-2.513,0.5,93,95,-0.612,7,7,3,0.0174418604651162,"loop",-0.8,5.97,0.0019404915912031,127.447513812155,127.447463030391,127.547977311481,114.177692609973,4,0,0,0,0,0,0,0,0,6,2,-2,4,0,0,0,0,0,2,0,0,4,0,4,-2,-0.279381965552178,-0.0364341085271317,0.154063622258321,-0.42847399829497,0.280898876404494,0.978947368421053,-0.504118616144975,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.728,-0.553,"8:7","147/150","G:S:M:A:T:L:R:E:Y:F:Q",4.84770422501703,1.95563371409724e-06,1.01886282652061,4.75795573146171,27.0895053611136,2275.86435679243,2.10533136786968,2.29679039420522e-19,18.638878636844,20.9103539725502,5063.91643152716,1.19139212303841e-26,"lineage2","dr_mutations_pyrazinamide","PRO",0,"SAMN02360556","SRR1048852_SRR1013554_SRR1048853_SRR1013553","lineage2.2.2","kr","South Korea","pnca_p.thr135pro","A","T","THR","TA135","pnca_complex.pdb"
|
|
"T135P","L4","PZA","T","T135",135,"P",NA,"MDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",6.021,-1.103,-0.141,4.22994,-2.513,0.5,93,95,-0.612,7,7,3,0.0174418604651162,"loop",-0.8,5.97,0.0019404915912031,127.447513812155,127.447463030391,127.547977311481,114.177692609973,4,0,0,0,0,0,0,0,0,6,2,-2,4,0,0,0,0,0,2,0,0,4,0,4,-2,-0.279381965552178,-0.0364341085271317,0.154063622258321,-0.42847399829497,0.280898876404494,0.978947368421053,-0.504118616144975,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.728,-0.553,"8:7","147/150","G:S:M:A:T:L:R:E:Y:F:Q",4.84770422501703,1.95563371409724e-06,1.01886282652061,4.75795573146171,27.0895053611136,2275.86435679243,2.10533136786968,2.29679039420522e-19,18.638878636844,20.9103539725502,5063.91643152716,1.19139212303841e-26,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR751488","ERR751488","lineage4","pe","","pnca_p.thr135pro","A","T","THR","TA135","pnca_complex.pdb"
|
|
"T135P","L2","PZA","T","T135",135,"P",NA,"XDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",6.021,-1.103,-0.141,4.22994,-2.513,0.5,93,95,-0.612,7,7,3,0.0174418604651162,"loop",-0.8,5.97,0.0019404915912031,127.447513812155,127.447463030391,127.547977311481,114.177692609973,4,0,0,0,0,0,0,0,0,6,2,-2,4,0,0,0,0,0,2,0,0,4,0,4,-2,-0.279381965552178,-0.0364341085271317,0.154063622258321,-0.42847399829497,0.280898876404494,0.978947368421053,-0.504118616144975,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.728,-0.553,"8:7","147/150","G:S:M:A:T:L:R:E:Y:F:Q",4.84770422501703,1.95563371409724e-06,1.01886282652061,4.75795573146171,27.0895053611136,2275.86435679243,2.10533136786968,2.29679039420522e-19,18.638878636844,20.9103539725502,5063.91643152716,1.19139212303841e-26,"lineage2","dr_mutations_pyrazinamide","PRO",0,"SAMN02398713","SRR1048008_SRR1144783","lineage2.2.2","kr","South Korea","pnca_p.thr135pro","A","T","THR","TA135","pnca_complex.pdb"
|
|
"T135P","L2","PZA","T","T135",135,"P",NA,"XDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",6.021,-1.103,-0.141,4.22994,-2.513,0.5,93,95,-0.612,7,7,3,0.0174418604651162,"loop",-0.8,5.97,0.0019404915912031,127.447513812155,127.447463030391,127.547977311481,114.177692609973,4,0,0,0,0,0,0,0,0,6,2,-2,4,0,0,0,0,0,2,0,0,4,0,4,-2,-0.279381965552178,-0.0364341085271317,0.154063622258321,-0.42847399829497,0.280898876404494,0.978947368421053,-0.504118616144975,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.728,-0.553,"8:7","147/150","G:S:M:A:T:L:R:E:Y:F:Q",4.84770422501703,1.95563371409724e-06,1.01886282652061,4.75795573146171,27.0895053611136,2275.86435679243,2.10533136786968,2.29679039420522e-19,18.638878636844,20.9103539725502,5063.91643152716,1.19139212303841e-26,"lineage2","dr_mutations_pyrazinamide","PRO",0,"SAMN02360613","SRR1049062_SRR1013668_SRR1013669_SRR1049063","lineage2.2.2","kr","South Korea","pnca_p.thr135pro","A","T","THR","TA135","pnca_complex.pdb"
|
|
"T135P","L2","PZA","T","T135",135,"P",NA,"XDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",6.021,-1.103,-0.141,4.22994,-2.513,0.5,93,95,-0.612,7,7,3,0.0174418604651162,"loop",-0.8,5.97,0.0019404915912031,127.447513812155,127.447463030391,127.547977311481,114.177692609973,4,0,0,0,0,0,0,0,0,6,2,-2,4,0,0,0,0,0,2,0,0,4,0,4,-2,-0.279381965552178,-0.0364341085271317,0.154063622258321,-0.42847399829497,0.280898876404494,0.978947368421053,-0.504118616144975,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.728,-0.553,"8:7","147/150","G:S:M:A:T:L:R:E:Y:F:Q",4.84770422501703,1.95563371409724e-06,1.01886282652061,4.75795573146171,27.0895053611136,2275.86435679243,2.10533136786968,2.29679039420522e-19,18.638878636844,20.9103539725502,5063.91643152716,1.19139212303841e-26,"lineage2","dr_mutations_pyrazinamide","PRO",0,"SAMN02398693","SRR1144776_SRR1050529","lineage2.2.2","kr","South Korea","pnca_p.thr135pro","A","T","THR","TA135","pnca_complex.pdb"
|
|
"T135P","L4","PZA","T","T135",135,"P",NA,"MDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",6.021,-1.103,-0.141,4.22994,-2.513,0.5,93,95,-0.612,7,7,3,0.0174418604651162,"loop",-0.8,5.97,0.0019404915912031,127.447513812155,127.447463030391,127.547977311481,114.177692609973,4,0,0,0,0,0,0,0,0,6,2,-2,4,0,0,0,0,0,2,0,0,4,0,4,-2,-0.279381965552178,-0.0364341085271317,0.154063622258321,-0.42847399829497,0.280898876404494,0.978947368421053,-0.504118616144975,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.728,-0.553,"8:7","147/150","G:S:M:A:T:L:R:E:Y:F:Q",4.84770422501703,1.95563371409724e-06,1.01886282652061,4.75795573146171,27.0895053611136,2275.86435679243,2.10533136786968,2.29679039420522e-19,18.638878636844,20.9103539725502,5063.91643152716,1.19139212303841e-26,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR751540","ERR751540","lineage4","pe","","pnca_p.thr135pro","A","T","THR","TA135","pnca_complex.pdb"
|
|
"T135P","L3","PZA","T","T135",135,"P",NA,"MDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",6.021,-1.103,-0.141,4.22994,-2.513,0.5,93,95,-0.612,7,7,3,0.0174418604651162,"loop",-0.8,5.97,0.0019404915912031,127.447513812155,127.447463030391,127.547977311481,114.177692609973,4,0,0,0,0,0,0,0,0,6,2,-2,4,0,0,0,0,0,2,0,0,4,0,4,-2,-0.279381965552178,-0.0364341085271317,0.154063622258321,-0.42847399829497,0.280898876404494,0.978947368421053,-0.504118616144975,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.728,-0.553,"8:7","147/150","G:S:M:A:T:L:R:E:Y:F:Q",4.84770422501703,1.95563371409724e-06,1.01886282652061,4.75795573146171,27.0895053611136,2275.86435679243,2.10533136786968,2.29679039420522e-19,18.638878636844,20.9103539725502,5063.91643152716,1.19139212303841e-26,"lineage3","dr_mutations_pyrazinamide","PRO",0,"SRR6397810","SRR6397810","lineage3","ca","Canada","pnca_p.thr135pro","A","T","THR","TA135","pnca_complex.pdb"
|
|
"T135P","L4","PZA","T","T135",135,"P",1,"MDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",6.021,-1.103,-0.141,4.22994,-2.513,0.5,93,95,-0.612,7,7,3,0.0174418604651162,"loop",-0.8,5.97,0.0019404915912031,127.447513812155,127.447463030391,127.547977311481,114.177692609973,4,0,0,0,0,0,0,0,0,6,2,-2,4,0,0,0,0,0,2,0,0,4,0,4,-2,-0.279381965552178,-0.0364341085271317,0.154063622258321,-0.42847399829497,0.280898876404494,0.978947368421053,-0.504118616144975,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.728,-0.553,"8:7","147/150","G:S:M:A:T:L:R:E:Y:F:Q",4.84770422501703,1.95563371409724e-06,1.01886282652061,4.75795573146171,27.0895053611136,2275.86435679243,2.10533136786968,2.29679039420522e-19,18.638878636844,20.9103539725502,5063.91643152716,1.19139212303841e-26,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR2515210","ERR2515210","lineage4.1.2.1","za","South Africa","pnca_p.thr135pro","A","T","THR","TA135","pnca_complex.pdb"
|
|
"T135P","L2","PZA","T","T135",135,"P",1,"Pre-XDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",6.021,-1.103,-0.141,4.22994,-2.513,0.5,93,95,-0.612,7,7,3,0.0174418604651162,"loop",-0.8,5.97,0.0019404915912031,127.447513812155,127.447463030391,127.547977311481,114.177692609973,4,0,0,0,0,0,0,0,0,6,2,-2,4,0,0,0,0,0,2,0,0,4,0,4,-2,-0.279381965552178,-0.0364341085271317,0.154063622258321,-0.42847399829497,0.280898876404494,0.978947368421053,-0.504118616144975,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.728,-0.553,"8:7","147/150","G:S:M:A:T:L:R:E:Y:F:Q",4.84770422501703,1.95563371409724e-06,1.01886282652061,4.75795573146171,27.0895053611136,2275.86435679243,2.10533136786968,2.29679039420522e-19,18.638878636844,20.9103539725502,5063.91643152716,1.19139212303841e-26,"lineage2","dr_mutations_pyrazinamide","PRO",0,"ERR1873455","ERR1873455","lineage2.2.1","za","South Africa","pnca_p.thr135pro","A","T","THR","TA135","pnca_complex.pdb"
|
|
"T135P","L3","PZA","T","T135",135,"P",1,"Pre-MDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",6.021,-1.103,-0.141,4.22994,-2.513,0.5,93,95,-0.612,7,7,3,0.0174418604651162,"loop",-0.8,5.97,0.0019404915912031,127.447513812155,127.447463030391,127.547977311481,114.177692609973,4,0,0,0,0,0,0,0,0,6,2,-2,4,0,0,0,0,0,2,0,0,4,0,4,-2,-0.279381965552178,-0.0364341085271317,0.154063622258321,-0.42847399829497,0.280898876404494,0.978947368421053,-0.504118616144975,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.728,-0.553,"8:7","147/150","G:S:M:A:T:L:R:E:Y:F:Q",4.84770422501703,1.95563371409724e-06,1.01886282652061,4.75795573146171,27.0895053611136,2275.86435679243,2.10533136786968,2.29679039420522e-19,18.638878636844,20.9103539725502,5063.91643152716,1.19139212303841e-26,"lineage3","dr_mutations_pyrazinamide","PRO",0,"ERR2510611","ERR2510611","lineage3","pk","Pakistan","pnca_p.thr135pro","A","T","THR","TA135","pnca_complex.pdb"
|
|
"T135P","L4","PZA","T","T135",135,"P",NA,"MDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",6.021,-1.103,-0.141,4.22994,-2.513,0.5,93,95,-0.612,7,7,3,0.0174418604651162,"loop",-0.8,5.97,0.0019404915912031,127.447513812155,127.447463030391,127.547977311481,114.177692609973,4,0,0,0,0,0,0,0,0,6,2,-2,4,0,0,0,0,0,2,0,0,4,0,4,-2,-0.279381965552178,-0.0364341085271317,0.154063622258321,-0.42847399829497,0.280898876404494,0.978947368421053,-0.504118616144975,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.728,-0.553,"8:7","147/150","G:S:M:A:T:L:R:E:Y:F:Q",4.84770422501703,1.95563371409724e-06,1.01886282652061,4.75795573146171,27.0895053611136,2275.86435679243,2.10533136786968,2.29679039420522e-19,18.638878636844,20.9103539725502,5063.91643152716,1.19139212303841e-26,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR779923","ERR779923","lineage4","pe","","pnca_p.thr135pro","A","T","THR","TA135","pnca_complex.pdb"
|
|
"T135P","L2","PZA","T","T135",135,"P",NA,"XDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",6.021,-1.103,-0.141,4.22994,-2.513,0.5,93,95,-0.612,7,7,3,0.0174418604651162,"loop",-0.8,5.97,0.0019404915912031,127.447513812155,127.447463030391,127.547977311481,114.177692609973,4,0,0,0,0,0,0,0,0,6,2,-2,4,0,0,0,0,0,2,0,0,4,0,4,-2,-0.279381965552178,-0.0364341085271317,0.154063622258321,-0.42847399829497,0.280898876404494,0.978947368421053,-0.504118616144975,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.728,-0.553,"8:7","147/150","G:S:M:A:T:L:R:E:Y:F:Q",4.84770422501703,1.95563371409724e-06,1.01886282652061,4.75795573146171,27.0895053611136,2275.86435679243,2.10533136786968,2.29679039420522e-19,18.638878636844,20.9103539725502,5063.91643152716,1.19139212303841e-26,"lineage2","dr_mutations_pyrazinamide","PRO",0,"SAMN02360551","SRR1048842_SRR1048843_SRR1013544_SRR1013543","lineage2.2.2","kr","South Korea","pnca_p.thr135pro","A","T","THR","TA135","pnca_complex.pdb"
|
|
"T135P","L4","PZA","T","T135",135,"P",NA,"MDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",6.021,-1.103,-0.141,4.22994,-2.513,0.5,93,95,-0.612,7,7,3,0.0174418604651162,"loop",-0.8,5.97,0.0019404915912031,127.447513812155,127.447463030391,127.547977311481,114.177692609973,4,0,0,0,0,0,0,0,0,6,2,-2,4,0,0,0,0,0,2,0,0,4,0,4,-2,-0.279381965552178,-0.0364341085271317,0.154063622258321,-0.42847399829497,0.280898876404494,0.978947368421053,-0.504118616144975,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.728,-0.553,"8:7","147/150","G:S:M:A:T:L:R:E:Y:F:Q",4.84770422501703,1.95563371409724e-06,1.01886282652061,4.75795573146171,27.0895053611136,2275.86435679243,2.10533136786968,2.29679039420522e-19,18.638878636844,20.9103539725502,5063.91643152716,1.19139212303841e-26,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR751356","ERR751356","lineage4","pe","","pnca_p.thr135pro","A","T","THR","TA135","pnca_complex.pdb"
|
|
"T135P","L4","PZA","T","T135",135,"P",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",6.021,-1.103,-0.141,4.22994,-2.513,0.5,93,95,-0.612,7,7,3,0.0174418604651162,"loop",-0.8,5.97,0.0019404915912031,127.447513812155,127.447463030391,127.547977311481,114.177692609973,4,0,0,0,0,0,0,0,0,6,2,-2,4,0,0,0,0,0,2,0,0,4,0,4,-2,-0.279381965552178,-0.0364341085271317,0.154063622258321,-0.42847399829497,0.280898876404494,0.978947368421053,-0.504118616144975,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.728,-0.553,"8:7","147/150","G:S:M:A:T:L:R:E:Y:F:Q",4.84770422501703,1.95563371409724e-06,1.01886282652061,4.75795573146171,27.0895053611136,2275.86435679243,2.10533136786968,2.29679039420522e-19,18.638878636844,20.9103539725502,5063.91643152716,1.19139212303841e-26,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR751452","ERR751452","lineage4","pe","","pnca_p.thr135pro","A","T","THR","TA135","pnca_complex.pdb"
|
|
"T135P","L4","PZA","T","T135",135,"P",0,"Pre-XDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",6.021,-1.103,-0.141,4.22994,-2.513,0.5,93,95,-0.612,7,7,3,0.0174418604651162,"loop",-0.8,5.97,0.0019404915912031,127.447513812155,127.447463030391,127.547977311481,114.177692609973,4,0,0,0,0,0,0,0,0,6,2,-2,4,0,0,0,0,0,2,0,0,4,0,4,-2,-0.279381965552178,-0.0364341085271317,0.154063622258321,-0.42847399829497,0.280898876404494,0.978947368421053,-0.504118616144975,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.728,-0.553,"8:7","147/150","G:S:M:A:T:L:R:E:Y:F:Q",4.84770422501703,1.95563371409724e-06,1.01886282652061,4.75795573146171,27.0895053611136,2275.86435679243,2.10533136786968,2.29679039420522e-19,18.638878636844,20.9103539725502,5063.91643152716,1.19139212303841e-26,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR2510643","ERR2510643","lineage4.5","pk","Pakistan","pnca_p.thr135pro","A","T","THR","TA135","pnca_complex.pdb"
|
|
"T135P","L4","PZA","T","T135",135,"P",NA,"MDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",6.021,-1.103,-0.141,4.22994,-2.513,0.5,93,95,-0.612,7,7,3,0.0174418604651162,"loop",-0.8,5.97,0.0019404915912031,127.447513812155,127.447463030391,127.547977311481,114.177692609973,4,0,0,0,0,0,0,0,0,6,2,-2,4,0,0,0,0,0,2,0,0,4,0,4,-2,-0.279381965552178,-0.0364341085271317,0.154063622258321,-0.42847399829497,0.280898876404494,0.978947368421053,-0.504118616144975,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.728,-0.553,"8:7","147/150","G:S:M:A:T:L:R:E:Y:F:Q",4.84770422501703,1.95563371409724e-06,1.01886282652061,4.75795573146171,27.0895053611136,2275.86435679243,2.10533136786968,2.29679039420522e-19,18.638878636844,20.9103539725502,5063.91643152716,1.19139212303841e-26,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR751531","ERR751531","lineage4","pe","","pnca_p.thr135pro","A","T","THR","TA135","pnca_complex.pdb"
|
|
"T135P","L4","PZA","T","T135",135,"P",1,"MDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",6.021,-1.103,-0.141,4.22994,-2.513,0.5,93,95,-0.612,7,7,3,0.0174418604651162,"loop",-0.8,5.97,0.0019404915912031,127.447513812155,127.447463030391,127.547977311481,114.177692609973,4,0,0,0,0,0,0,0,0,6,2,-2,4,0,0,0,0,0,2,0,0,4,0,4,-2,-0.279381965552178,-0.0364341085271317,0.154063622258321,-0.42847399829497,0.280898876404494,0.978947368421053,-0.504118616144975,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.728,-0.553,"8:7","147/150","G:S:M:A:T:L:R:E:Y:F:Q",4.84770422501703,1.95563371409724e-06,1.01886282652061,4.75795573146171,27.0895053611136,2275.86435679243,2.10533136786968,2.29679039420522e-19,18.638878636844,20.9103539725502,5063.91643152716,1.19139212303841e-26,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR552010","ERR552010","lineage4.1.2.1","sz","Swaziland","pnca_p.thr135pro","A","T","THR","TA135","pnca_complex.pdb"
|
|
"T135P","L4","PZA","T","T135",135,"P",NA,"MDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",6.021,-1.103,-0.141,4.22994,-2.513,0.5,93,95,-0.612,7,7,3,0.0174418604651162,"loop",-0.8,5.97,0.0019404915912031,127.447513812155,127.447463030391,127.547977311481,114.177692609973,4,0,0,0,0,0,0,0,0,6,2,-2,4,0,0,0,0,0,2,0,0,4,0,4,-2,-0.279381965552178,-0.0364341085271317,0.154063622258321,-0.42847399829497,0.280898876404494,0.978947368421053,-0.504118616144975,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.728,-0.553,"8:7","147/150","G:S:M:A:T:L:R:E:Y:F:Q",4.84770422501703,1.95563371409724e-06,1.01886282652061,4.75795573146171,27.0895053611136,2275.86435679243,2.10533136786968,2.29679039420522e-19,18.638878636844,20.9103539725502,5063.91643152716,1.19139212303841e-26,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR751411","ERR751411","lineage4","pe","","pnca_p.thr135pro","A","T","THR","TA135","pnca_complex.pdb"
|
|
"T135P","L4","PZA","T","T135",135,"P",1,"MDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",6.021,-1.103,-0.141,4.22994,-2.513,0.5,93,95,-0.612,7,7,3,0.0174418604651162,"loop",-0.8,5.97,0.0019404915912031,127.447513812155,127.447463030391,127.547977311481,114.177692609973,4,0,0,0,0,0,0,0,0,6,2,-2,4,0,0,0,0,0,2,0,0,4,0,4,-2,-0.279381965552178,-0.0364341085271317,0.154063622258321,-0.42847399829497,0.280898876404494,0.978947368421053,-0.504118616144975,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.728,-0.553,"8:7","147/150","G:S:M:A:T:L:R:E:Y:F:Q",4.84770422501703,1.95563371409724e-06,1.01886282652061,4.75795573146171,27.0895053611136,2275.86435679243,2.10533136786968,2.29679039420522e-19,18.638878636844,20.9103539725502,5063.91643152716,1.19139212303841e-26,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR551045","ERR551045","lineage4.1.2.1","sz","Swaziland","pnca_p.thr135pro","A","T","THR","TA135","pnca_complex.pdb"
|
|
"T135P","L2","PZA","T","T135",135,"P",1,"Pre-XDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",6.021,-1.103,-0.141,4.22994,-2.513,0.5,93,95,-0.612,7,7,3,0.0174418604651162,"loop",-0.8,5.97,0.0019404915912031,127.447513812155,127.447463030391,127.547977311481,114.177692609973,4,0,0,0,0,0,0,0,0,6,2,-2,4,0,0,0,0,0,2,0,0,4,0,4,-2,-0.279381965552178,-0.0364341085271317,0.154063622258321,-0.42847399829497,0.280898876404494,0.978947368421053,-0.504118616144975,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.728,-0.553,"8:7","147/150","G:S:M:A:T:L:R:E:Y:F:Q",4.84770422501703,1.95563371409724e-06,1.01886282652061,4.75795573146171,27.0895053611136,2275.86435679243,2.10533136786968,2.29679039420522e-19,18.638878636844,20.9103539725502,5063.91643152716,1.19139212303841e-26,"lineage2","dr_mutations_pyrazinamide","PRO",0,"ERR1873563","ERR1873563","lineage2.2.1","za","South Africa","pnca_p.thr135pro","A","T","THR","TA135","pnca_complex.pdb"
|
|
"T135P","L4","PZA","T","T135",135,"P",NA,"MDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",6.021,-1.103,-0.141,4.22994,-2.513,0.5,93,95,-0.612,7,7,3,0.0174418604651162,"loop",-0.8,5.97,0.0019404915912031,127.447513812155,127.447463030391,127.547977311481,114.177692609973,4,0,0,0,0,0,0,0,0,6,2,-2,4,0,0,0,0,0,2,0,0,4,0,4,-2,-0.279381965552178,-0.0364341085271317,0.154063622258321,-0.42847399829497,0.280898876404494,0.978947368421053,-0.504118616144975,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.728,-0.553,"8:7","147/150","G:S:M:A:T:L:R:E:Y:F:Q",4.84770422501703,1.95563371409724e-06,1.01886282652061,4.75795573146171,27.0895053611136,2275.86435679243,2.10533136786968,2.29679039420522e-19,18.638878636844,20.9103539725502,5063.91643152716,1.19139212303841e-26,"lineage4","dr_mutations_pyrazinamide","PRO",0,"SRR024053","SRR024053","lineage4.8","","unknown","pnca_p.thr135pro","A","T","THR","TA135","pnca_complex.pdb"
|
|
"T135P","L4","PZA","T","T135",135,"P",1,"MDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",6.021,-1.103,-0.141,4.22994,-2.513,0.5,93,95,-0.612,7,7,3,0.0174418604651162,"loop",-0.8,5.97,0.0019404915912031,127.447513812155,127.447463030391,127.547977311481,114.177692609973,4,0,0,0,0,0,0,0,0,6,2,-2,4,0,0,0,0,0,2,0,0,4,0,4,-2,-0.279381965552178,-0.0364341085271317,0.154063622258321,-0.42847399829497,0.280898876404494,0.978947368421053,-0.504118616144975,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.728,-0.553,"8:7","147/150","G:S:M:A:T:L:R:E:Y:F:Q",4.84770422501703,1.95563371409724e-06,1.01886282652061,4.75795573146171,27.0895053611136,2275.86435679243,2.10533136786968,2.29679039420522e-19,18.638878636844,20.9103539725502,5063.91643152716,1.19139212303841e-26,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR1034887","ERR1034887","lineage4.6.1.2","pt","Portugal","pnca_p.thr135pro","A","T","THR","TA135","pnca_complex.pdb"
|
|
"T135P","L4","PZA","T","T135",135,"P",1,"MDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",6.021,-1.103,-0.141,4.22994,-2.513,0.5,93,95,-0.612,7,7,3,0.0174418604651162,"loop",-0.8,5.97,0.0019404915912031,127.447513812155,127.447463030391,127.547977311481,114.177692609973,4,0,0,0,0,0,0,0,0,6,2,-2,4,0,0,0,0,0,2,0,0,4,0,4,-2,-0.279381965552178,-0.0364341085271317,0.154063622258321,-0.42847399829497,0.280898876404494,0.978947368421053,-0.504118616144975,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.728,-0.553,"8:7","147/150","G:S:M:A:T:L:R:E:Y:F:Q",4.84770422501703,1.95563371409724e-06,1.01886282652061,4.75795573146171,27.0895053611136,2275.86435679243,2.10533136786968,2.29679039420522e-19,18.638878636844,20.9103539725502,5063.91643152716,1.19139212303841e-26,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR2515284","ERR2515284","lineage4.1.2.1","za","South Africa","pnca_p.thr135pro","A","T","THR","TA135","pnca_complex.pdb"
|
|
"T135P","L4","PZA","T","T135",135,"P",NA,"MDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",6.021,-1.103,-0.141,4.22994,-2.513,0.5,93,95,-0.612,7,7,3,0.0174418604651162,"loop",-0.8,5.97,0.0019404915912031,127.447513812155,127.447463030391,127.547977311481,114.177692609973,4,0,0,0,0,0,0,0,0,6,2,-2,4,0,0,0,0,0,2,0,0,4,0,4,-2,-0.279381965552178,-0.0364341085271317,0.154063622258321,-0.42847399829497,0.280898876404494,0.978947368421053,-0.504118616144975,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.728,-0.553,"8:7","147/150","G:S:M:A:T:L:R:E:Y:F:Q",4.84770422501703,1.95563371409724e-06,1.01886282652061,4.75795573146171,27.0895053611136,2275.86435679243,2.10533136786968,2.29679039420522e-19,18.638878636844,20.9103539725502,5063.91643152716,1.19139212303841e-26,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR775380","ERR775380","lineage4","pe","","pnca_p.thr135pro","A","T","THR","TA135","pnca_complex.pdb"
|
|
"T135P","L1","PZA","T","T135",135,"P",1,"MDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",6.021,-1.103,-0.141,4.22994,-2.513,0.5,93,95,-0.612,7,7,3,0.0174418604651162,"loop",-0.8,5.97,0.0019404915912031,127.447513812155,127.447463030391,127.547977311481,114.177692609973,4,0,0,0,0,0,0,0,0,6,2,-2,4,0,0,0,0,0,2,0,0,4,0,4,-2,-0.279381965552178,-0.0364341085271317,0.154063622258321,-0.42847399829497,0.280898876404494,0.978947368421053,-0.504118616144975,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.728,-0.553,"8:7","147/150","G:S:M:A:T:L:R:E:Y:F:Q",4.84770422501703,1.95563371409724e-06,1.01886282652061,4.75795573146171,27.0895053611136,2275.86435679243,2.10533136786968,2.29679039420522e-19,18.638878636844,20.9103539725502,5063.91643152716,1.19139212303841e-26,"lineage1","dr_mutations_pyrazinamide","PRO",0,"ERR2517018","ERR2517018","lineage1.1.3","gb","UK","pnca_p.thr135pro","A","T","THR","TA135","pnca_complex.pdb"
|
|
"T135P","L2","PZA","T","T135",135,"P",NA,"XDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",6.021,-1.103,-0.141,4.22994,-2.513,0.5,93,95,-0.612,7,7,3,0.0174418604651162,"loop",-0.8,5.97,0.0019404915912031,127.447513812155,127.447463030391,127.547977311481,114.177692609973,4,0,0,0,0,0,0,0,0,6,2,-2,4,0,0,0,0,0,2,0,0,4,0,4,-2,-0.279381965552178,-0.0364341085271317,0.154063622258321,-0.42847399829497,0.280898876404494,0.978947368421053,-0.504118616144975,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.728,-0.553,"8:7","147/150","G:S:M:A:T:L:R:E:Y:F:Q",4.84770422501703,1.95563371409724e-06,1.01886282652061,4.75795573146171,27.0895053611136,2275.86435679243,2.10533136786968,2.29679039420522e-19,18.638878636844,20.9103539725502,5063.91643152716,1.19139212303841e-26,"lineage2","dr_mutations_pyrazinamide","PRO",0,"SAMN02398712","SRR1144780_SRR1047999","lineage2.2.2","kr","South Korea","pnca_p.thr135pro","A","T","THR","TA135","pnca_complex.pdb"
|
|
"T135P","L2","PZA","T","T135",135,"P",1,"Pre-XDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",6.021,-1.103,-0.141,4.22994,-2.513,0.5,93,95,-0.612,7,7,3,0.0174418604651162,"loop",-0.8,5.97,0.0019404915912031,127.447513812155,127.447463030391,127.547977311481,114.177692609973,4,0,0,0,0,0,0,0,0,6,2,-2,4,0,0,0,0,0,2,0,0,4,0,4,-2,-0.279381965552178,-0.0364341085271317,0.154063622258321,-0.42847399829497,0.280898876404494,0.978947368421053,-0.504118616144975,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.728,-0.553,"8:7","147/150","G:S:M:A:T:L:R:E:Y:F:Q",4.84770422501703,1.95563371409724e-06,1.01886282652061,4.75795573146171,27.0895053611136,2275.86435679243,2.10533136786968,2.29679039420522e-19,18.638878636844,20.9103539725502,5063.91643152716,1.19139212303841e-26,"lineage2","dr_mutations_pyrazinamide","PRO",0,"ERR552141","ERR552141","lineage2.2.1","ru","Russia","pnca_p.thr135pro","A","T","THR","TA135","pnca_complex.pdb"
|
|
"T135P","L2","PZA","T","T135",135,"P",1,"Pre-XDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",6.021,-1.103,-0.141,4.22994,-2.513,0.5,93,95,-0.612,7,7,3,0.0174418604651162,"loop",-0.8,5.97,0.0019404915912031,127.447513812155,127.447463030391,127.547977311481,114.177692609973,4,0,0,0,0,0,0,0,0,6,2,-2,4,0,0,0,0,0,2,0,0,4,0,4,-2,-0.279381965552178,-0.0364341085271317,0.154063622258321,-0.42847399829497,0.280898876404494,0.978947368421053,-0.504118616144975,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.728,-0.553,"8:7","147/150","G:S:M:A:T:L:R:E:Y:F:Q",4.84770422501703,1.95563371409724e-06,1.01886282652061,4.75795573146171,27.0895053611136,2275.86435679243,2.10533136786968,2.29679039420522e-19,18.638878636844,20.9103539725502,5063.91643152716,1.19139212303841e-26,"lineage2","dr_mutations_pyrazinamide","PRO",0,"ERR2512718","ERR2512718","lineage2.2.1","gb","UK","pnca_p.thr135pro","A","T","THR","TA135","pnca_complex.pdb"
|
|
"T135P","L4","PZA","T","T135",135,"P",NA,"MDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",6.021,-1.103,-0.141,4.22994,-2.513,0.5,93,95,-0.612,7,7,3,0.0174418604651162,"loop",-0.8,5.97,0.0019404915912031,127.447513812155,127.447463030391,127.547977311481,114.177692609973,4,0,0,0,0,0,0,0,0,6,2,-2,4,0,0,0,0,0,2,0,0,4,0,4,-2,-0.279381965552178,-0.0364341085271317,0.154063622258321,-0.42847399829497,0.280898876404494,0.978947368421053,-0.504118616144975,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.728,-0.553,"8:7","147/150","G:S:M:A:T:L:R:E:Y:F:Q",4.84770422501703,1.95563371409724e-06,1.01886282652061,4.75795573146171,27.0895053611136,2275.86435679243,2.10533136786968,2.29679039420522e-19,18.638878636844,20.9103539725502,5063.91643152716,1.19139212303841e-26,"lineage4","dr_mutations_pyrazinamide","PRO",0,"SAMN02414948","SRR1162867_SRR1165457_SRR1167058_SRR1162877","lineage4.1","se","Sweden","pnca_p.thr135pro","A","T","THR","TA135","pnca_complex.pdb"
|
|
"T135P","L2","PZA","T","T135",135,"P",1,"Pre-XDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",6.021,-1.103,-0.141,4.22994,-2.513,0.5,93,95,-0.612,7,7,3,0.0174418604651162,"loop",-0.8,5.97,0.0019404915912031,127.447513812155,127.447463030391,127.547977311481,114.177692609973,4,0,0,0,0,0,0,0,0,6,2,-2,4,0,0,0,0,0,2,0,0,4,0,4,-2,-0.279381965552178,-0.0364341085271317,0.154063622258321,-0.42847399829497,0.280898876404494,0.978947368421053,-0.504118616144975,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.728,-0.553,"8:7","147/150","G:S:M:A:T:L:R:E:Y:F:Q",4.84770422501703,1.95563371409724e-06,1.01886282652061,4.75795573146171,27.0895053611136,2275.86435679243,2.10533136786968,2.29679039420522e-19,18.638878636844,20.9103539725502,5063.91643152716,1.19139212303841e-26,"lineage2","dr_mutations_pyrazinamide","PRO",0,"ERR027451","ERR027451","lineage2.2.1","ru","Russia","pnca_p.thr135pro","A","T","THR","TA135","pnca_complex.pdb"
|
|
"T135P","L2","PZA","T","T135",135,"P",NA,"XDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",6.021,-1.103,-0.141,4.22994,-2.513,0.5,93,95,-0.612,7,7,3,0.0174418604651162,"loop",-0.8,5.97,0.0019404915912031,127.447513812155,127.447463030391,127.547977311481,114.177692609973,4,0,0,0,0,0,0,0,0,6,2,-2,4,0,0,0,0,0,2,0,0,4,0,4,-2,-0.279381965552178,-0.0364341085271317,0.154063622258321,-0.42847399829497,0.280898876404494,0.978947368421053,-0.504118616144975,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.728,-0.553,"8:7","147/150","G:S:M:A:T:L:R:E:Y:F:Q",4.84770422501703,1.95563371409724e-06,1.01886282652061,4.75795573146171,27.0895053611136,2275.86435679243,2.10533136786968,2.29679039420522e-19,18.638878636844,20.9103539725502,5063.91643152716,1.19139212303841e-26,"lineage2","dr_mutations_pyrazinamide","PRO",0,"SAMN02360619","SRR1049075_SRR1013680_SRR1049074_SRR1013679","lineage2.2.2","kr","South Korea","pnca_p.thr135pro","A","T","THR","TA135","pnca_complex.pdb"
|
|
"T135P","L4","PZA","T","T135",135,"P",NA,"MDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",6.021,-1.103,-0.141,4.22994,-2.513,0.5,93,95,-0.612,7,7,3,0.0174418604651162,"loop",-0.8,5.97,0.0019404915912031,127.447513812155,127.447463030391,127.547977311481,114.177692609973,4,0,0,0,0,0,0,0,0,6,2,-2,4,0,0,0,0,0,2,0,0,4,0,4,-2,-0.279381965552178,-0.0364341085271317,0.154063622258321,-0.42847399829497,0.280898876404494,0.978947368421053,-0.504118616144975,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.728,-0.553,"8:7","147/150","G:S:M:A:T:L:R:E:Y:F:Q",4.84770422501703,1.95563371409724e-06,1.01886282652061,4.75795573146171,27.0895053611136,2275.86435679243,2.10533136786968,2.29679039420522e-19,18.638878636844,20.9103539725502,5063.91643152716,1.19139212303841e-26,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR751526","ERR751526","lineage4","pe","","pnca_p.thr135pro","A","T","THR","TA135","pnca_complex.pdb"
|
|
"T135P","L4","PZA","T","T135",135,"P",NA,"MDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",6.021,-1.103,-0.141,4.22994,-2.513,0.5,93,95,-0.612,7,7,3,0.0174418604651162,"loop",-0.8,5.97,0.0019404915912031,127.447513812155,127.447463030391,127.547977311481,114.177692609973,4,0,0,0,0,0,0,0,0,6,2,-2,4,0,0,0,0,0,2,0,0,4,0,4,-2,-0.279381965552178,-0.0364341085271317,0.154063622258321,-0.42847399829497,0.280898876404494,0.978947368421053,-0.504118616144975,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.728,-0.553,"8:7","147/150","G:S:M:A:T:L:R:E:Y:F:Q",4.84770422501703,1.95563371409724e-06,1.01886282652061,4.75795573146171,27.0895053611136,2275.86435679243,2.10533136786968,2.29679039420522e-19,18.638878636844,20.9103539725502,5063.91643152716,1.19139212303841e-26,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR751465","ERR751465","lineage4","pe","","pnca_p.thr135pro","A","T","THR","TA135","pnca_complex.pdb"
|
|
"T135P","L2","PZA","T","T135",135,"P",1,"XDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",6.021,-1.103,-0.141,4.22994,-2.513,0.5,93,95,-0.612,7,7,3,0.0174418604651162,"loop",-0.8,5.97,0.0019404915912031,127.447513812155,127.447463030391,127.547977311481,114.177692609973,4,0,0,0,0,0,0,0,0,6,2,-2,4,0,0,0,0,0,2,0,0,4,0,4,-2,-0.279381965552178,-0.0364341085271317,0.154063622258321,-0.42847399829497,0.280898876404494,0.978947368421053,-0.504118616144975,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.728,-0.553,"8:7","147/150","G:S:M:A:T:L:R:E:Y:F:Q",4.84770422501703,1.95563371409724e-06,1.01886282652061,4.75795573146171,27.0895053611136,2275.86435679243,2.10533136786968,2.29679039420522e-19,18.638878636844,20.9103539725502,5063.91643152716,1.19139212303841e-26,"lineage2","dr_mutations_pyrazinamide","PRO",0,"ERR1873457","ERR1873457","lineage2.2.1","za","South Africa","pnca_p.thr135pro","A","T","THR","TA135","pnca_complex.pdb"
|
|
"T135P","L4","PZA","T","T135",135,"P",NA,"MDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",6.021,-1.103,-0.141,4.22994,-2.513,0.5,93,95,-0.612,7,7,3,0.0174418604651162,"loop",-0.8,5.97,0.0019404915912031,127.447513812155,127.447463030391,127.547977311481,114.177692609973,4,0,0,0,0,0,0,0,0,6,2,-2,4,0,0,0,0,0,2,0,0,4,0,4,-2,-0.279381965552178,-0.0364341085271317,0.154063622258321,-0.42847399829497,0.280898876404494,0.978947368421053,-0.504118616144975,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.728,-0.553,"8:7","147/150","G:S:M:A:T:L:R:E:Y:F:Q",4.84770422501703,1.95563371409724e-06,1.01886282652061,4.75795573146171,27.0895053611136,2275.86435679243,2.10533136786968,2.29679039420522e-19,18.638878636844,20.9103539725502,5063.91643152716,1.19139212303841e-26,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR2515165","ERR2515165","lineage4.1.2.1","za","South Africa","pnca_p.thr135pro","A","T","THR","TA135","pnca_complex.pdb"
|
|
"T135S","L4","PZA","T","T135",135,"S",0,"MDR","OM","hydrophobic","hydrophilic","neutral","neutral","polar","polar",6.021,-0.709,-1.605,0.77889,-1.567,-0.71,65,80,-0.612,7,7,3,0.0174418604651162,"loop",-0.8,5.97,7.18700589334483e-05,2.42412778478352,0.0001249735077034,0,1.03410070803344e-29,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,3,0,1,2,2,0,2,2,-0.179584599797366,-0.414728682170543,0.0283688692371011,-0.267178175618073,-0.18586387434555,0.684210526315789,-0.504118616144975,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.553,"8:7","147/150","G:S:M:A:T:L:R:E:Y:F:Q",-8.98740878149641,0.940032862253632,119.46804443549,-0.075228558598776,NA,4692673.51081184,0.384555509373631,1,0,0,188.544222231268,0.999999999999997,"lineage4","other_mutations_pyrazinamide","SER",0,"0600D-sc-2011-10-12T14:59:43Z-1289186,ERR117452","ERR117452","lineage4.3.3","ru","Russia,Samara","pnca_p.thr135ser","A","T","THR","TA135","pnca_complex.pdb"
|
|
"D136A","L2","PZA","D","D136",136,"A",1,"MDR","OM","hydrophilic","hydrophobic","acidic","non-polar","neg","non-polar",6.179,-2.506,0.66,1.50112,-0.993,1.78,73,85,-1.076,9,9,6,0.0310880829015544,"loop",-2.46666666666667,5.37,7.18700589334483e-05,9.70142977291842,188179.926264403,Inf,0.763784339928386,4,29,0,0,29,0,0,0,0,8,0,2,2,0,0,0,0,4,0,0,4,6,0,10,-3,-0.634751773049645,0.561224489795918,0.0546740579403988,-0.169309462915601,1,0.768421052631579,-0.886326194398682,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.152,-1.028,"9:9","147/150","S:E:D",12.1451538387252,0.919026337424193,119.468044436159,0.101660271548308,5.01153666069587e-06,NA,0.986835744238421,0.170978870202674,0.767057556984365,0.124324963210678,Inf,0.382146811758261,"lineage2","other_mutations_pyrazinamide","ALA",0,"ERR551545","ERR551545","lineage2.2.1","sz","Swaziland","pnca_p.asp136ala","A","T","ASP","DA136","pnca_complex.pdb"
|
|
"D136G","L2","PZA","D","D136",136,"G",0,"MDR","DM","hydrophilic","hydrophobic","acidic","neutral","neg","non-polar",6.179,-2.578,0.314,2.04991,-1.455,0.52,79,85,-1.076,9,9,6,0.0310880829015544,"loop",-2.46666666666667,5.37,0.0008624407072013,3.46852810205801,3.46852813512699,3.46809703626328,3.5269411605584,6,29,0,0,29,0,0,0,0,8,0,2,2,0,0,0,0,5,0,5,2,8,0,13,15,-0.652988855116515,0.267006802721088,0.0746621843107832,-0.248081841432225,0.292134831460674,0.831578947368421,-0.886326194398682,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.152,-1.028,"9:9","147/150","S:E:D",1.24373033542254,0.0337889223820885,0.585951699076682,2.12258166907334,1.02578380758221,10.8758695145359,0.540145217509122,0.0400825565026472,1.39704458655237,0.867177455332643,12.7072994899286,0.0603790832350862,"lineage2","dr_mutations_pyrazinamide","GLY",0,"ERR2516443","ERR2516443","lineage2.2.1","pe","Peru","pnca_p.asp136gly","A","T","ASP","DA136","pnca_complex.pdb"
|
|
"D136G","L2","PZA","D","D136",136,"G",1,"Pre-XDR","DM","hydrophilic","hydrophobic","acidic","neutral","neg","non-polar",6.179,-2.578,0.314,2.04991,-1.455,0.52,79,85,-1.076,9,9,6,0.0310880829015544,"loop",-2.46666666666667,5.37,0.0008624407072013,3.46852810205801,3.46852813512699,3.46809703626328,3.5269411605584,6,29,0,0,29,0,0,0,0,8,0,2,2,0,0,0,0,5,0,5,2,8,0,13,15,-0.652988855116515,0.267006802721088,0.0746621843107832,-0.248081841432225,0.292134831460674,0.831578947368421,-0.886326194398682,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.152,-1.028,"9:9","147/150","S:E:D",1.24373033542254,0.0337889223820885,0.585951699076682,2.12258166907334,1.02578380758221,10.8758695145359,0.540145217509122,0.0400825565026472,1.39704458655237,0.867177455332643,12.7072994899286,0.0603790832350862,"lineage2","dr_mutations_pyrazinamide","GLY",0,"ERS1831671","ERR2041937","lineage2.2.1","","Germany_extendedCAO","pnca_p.asp136gly","A","T","ASP","DA136","pnca_complex.pdb"
|
|
"D136G","L4","PZA","D","D136",136,"G",NA,"MDR","DM","hydrophilic","hydrophobic","acidic","neutral","neg","non-polar",6.179,-2.578,0.314,2.04991,-1.455,0.52,79,85,-1.076,9,9,6,0.0310880829015544,"loop",-2.46666666666667,5.37,0.0008624407072013,3.46852810205801,3.46852813512699,3.46809703626328,3.5269411605584,6,29,0,0,29,0,0,0,0,8,0,2,2,0,0,0,0,5,0,5,2,8,0,13,15,-0.652988855116515,0.267006802721088,0.0746621843107832,-0.248081841432225,0.292134831460674,0.831578947368421,-0.886326194398682,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.152,-1.028,"9:9","147/150","S:E:D",1.24373033542254,0.0337889223820885,0.585951699076682,2.12258166907334,1.02578380758221,10.8758695145359,0.540145217509122,0.0400825565026472,1.39704458655237,0.867177455332643,12.7072994899286,0.0603790832350862,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR775338","ERR775338","lineage4.3.3","pe","","pnca_p.asp136gly","A","T","ASP","DA136","pnca_complex.pdb"
|
|
"D136G","L4","PZA","D","D136",136,"G",1,"Pre-XDR","DM","hydrophilic","hydrophobic","acidic","neutral","neg","non-polar",6.179,-2.578,0.314,2.04991,-1.455,0.52,79,85,-1.076,9,9,6,0.0310880829015544,"loop",-2.46666666666667,5.37,0.0008624407072013,3.46852810205801,3.46852813512699,3.46809703626328,3.5269411605584,6,29,0,0,29,0,0,0,0,8,0,2,2,0,0,0,0,5,0,5,2,8,0,13,15,-0.652988855116515,0.267006802721088,0.0746621843107832,-0.248081841432225,0.292134831460674,0.831578947368421,-0.886326194398682,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.152,-1.028,"9:9","147/150","S:E:D",1.24373033542254,0.0337889223820885,0.585951699076682,2.12258166907334,1.02578380758221,10.8758695145359,0.540145217509122,0.0400825565026472,1.39704458655237,0.867177455332643,12.7072994899286,0.0603790832350862,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR2864224","ERR2864224","lineage4.3.2","pt","Portugal","pnca_p.asp136gly","A","T","ASP","DA136","pnca_complex.pdb"
|
|
"D136G","L2","PZA","D","D136",136,"G",0,"MDR","DM","hydrophilic","hydrophobic","acidic","neutral","neg","non-polar",6.179,-2.578,0.314,2.04991,-1.455,0.52,79,85,-1.076,9,9,6,0.0310880829015544,"loop",-2.46666666666667,5.37,0.0008624407072013,3.46852810205801,3.46852813512699,3.46809703626328,3.5269411605584,6,29,0,0,29,0,0,0,0,8,0,2,2,0,0,0,0,5,0,5,2,8,0,13,15,-0.652988855116515,0.267006802721088,0.0746621843107832,-0.248081841432225,0.292134831460674,0.831578947368421,-0.886326194398682,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.152,-1.028,"9:9","147/150","S:E:D",1.24373033542254,0.0337889223820885,0.585951699076682,2.12258166907334,1.02578380758221,10.8758695145359,0.540145217509122,0.0400825565026472,1.39704458655237,0.867177455332643,12.7072994899286,0.0603790832350862,"lineage2","dr_mutations_pyrazinamide","GLY",0,"ERR2514123","ERR2514123","lineage2.2.1.2","gb","UK","pnca_p.asp136gly","A","T","ASP","DA136","pnca_complex.pdb"
|
|
"D136G","L4","PZA","D","D136",136,"G",NA,"MDR","DM","hydrophilic","hydrophobic","acidic","neutral","neg","non-polar",6.179,-2.578,0.314,2.04991,-1.455,0.52,79,85,-1.076,9,9,6,0.0310880829015544,"loop",-2.46666666666667,5.37,0.0008624407072013,3.46852810205801,3.46852813512699,3.46809703626328,3.5269411605584,6,29,0,0,29,0,0,0,0,8,0,2,2,0,0,0,0,5,0,5,2,8,0,13,15,-0.652988855116515,0.267006802721088,0.0746621843107832,-0.248081841432225,0.292134831460674,0.831578947368421,-0.886326194398682,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.152,-1.028,"9:9","147/150","S:E:D",1.24373033542254,0.0337889223820885,0.585951699076682,2.12258166907334,1.02578380758221,10.8758695145359,0.540145217509122,0.0400825565026472,1.39704458655237,0.867177455332643,12.7072994899286,0.0603790832350862,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR2510238","ERR2510238","lineage4.3.3","pe","Peru","pnca_p.asp136gly","A","T","ASP","DA136","pnca_complex.pdb"
|
|
"D136G","L2","PZA","D","D136",136,"G",0,"MDR","DM","hydrophilic","hydrophobic","acidic","neutral","neg","non-polar",6.179,-2.578,0.314,2.04991,-1.455,0.52,79,85,-1.076,9,9,6,0.0310880829015544,"loop",-2.46666666666667,5.37,0.0008624407072013,3.46852810205801,3.46852813512699,3.46809703626328,3.5269411605584,6,29,0,0,29,0,0,0,0,8,0,2,2,0,0,0,0,5,0,5,2,8,0,13,15,-0.652988855116515,0.267006802721088,0.0746621843107832,-0.248081841432225,0.292134831460674,0.831578947368421,-0.886326194398682,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.152,-1.028,"9:9","147/150","S:E:D",1.24373033542254,0.0337889223820885,0.585951699076682,2.12258166907334,1.02578380758221,10.8758695145359,0.540145217509122,0.0400825565026472,1.39704458655237,0.867177455332643,12.7072994899286,0.0603790832350862,"lineage2","dr_mutations_pyrazinamide","GLY",0,"ERR2514267","ERR2514267","lineage2.2.1.2","gb","UK","pnca_p.asp136gly","A","T","ASP","DA136","pnca_complex.pdb"
|
|
"D136G","L2","PZA","D","D136",136,"G",NA,"MDR","DM","hydrophilic","hydrophobic","acidic","neutral","neg","non-polar",6.179,-2.578,0.314,2.04991,-1.455,0.52,79,85,-1.076,9,9,6,0.0310880829015544,"loop",-2.46666666666667,5.37,0.0008624407072013,3.46852810205801,3.46852813512699,3.46809703626328,3.5269411605584,6,29,0,0,29,0,0,0,0,8,0,2,2,0,0,0,0,5,0,5,2,8,0,13,15,-0.652988855116515,0.267006802721088,0.0746621843107832,-0.248081841432225,0.292134831460674,0.831578947368421,-0.886326194398682,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.152,-1.028,"9:9","147/150","S:E:D",1.24373033542254,0.0337889223820885,0.585951699076682,2.12258166907334,1.02578380758221,10.8758695145359,0.540145217509122,0.0400825565026472,1.39704458655237,0.867177455332643,12.7072994899286,0.0603790832350862,"lineage2","dr_mutations_pyrazinamide","GLY",0,"SRR5818616","SRR5818616","lineage2.2.1","dj","Djibouti","pnca_p.asp136gly","A","T","ASP","DA136","pnca_complex.pdb"
|
|
"D136G","L2","PZA","D","D136",136,"G",NA,"MDR","DM","hydrophilic","hydrophobic","acidic","neutral","neg","non-polar",6.179,-2.578,0.314,2.04991,-1.455,0.52,79,85,-1.076,9,9,6,0.0310880829015544,"loop",-2.46666666666667,5.37,0.0008624407072013,3.46852810205801,3.46852813512699,3.46809703626328,3.5269411605584,6,29,0,0,29,0,0,0,0,8,0,2,2,0,0,0,0,5,0,5,2,8,0,13,15,-0.652988855116515,0.267006802721088,0.0746621843107832,-0.248081841432225,0.292134831460674,0.831578947368421,-0.886326194398682,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.152,-1.028,"9:9","147/150","S:E:D",1.24373033542254,0.0337889223820885,0.585951699076682,2.12258166907334,1.02578380758221,10.8758695145359,0.540145217509122,0.0400825565026472,1.39704458655237,0.867177455332643,12.7072994899286,0.0603790832350862,"lineage2","dr_mutations_pyrazinamide","GLY",0,"SRS797198","SRR1723717","lineage2.2.1","cn","China:Shandong","pnca_p.asp136gly","A","T","ASP","DA136","pnca_complex.pdb"
|
|
"D136G","L4","PZA","D","D136",136,"G",0,"MDR","DM","hydrophilic","hydrophobic","acidic","neutral","neg","non-polar",6.179,-2.578,0.314,2.04991,-1.455,0.52,79,85,-1.076,9,9,6,0.0310880829015544,"loop",-2.46666666666667,5.37,0.0008624407072013,3.46852810205801,3.46852813512699,3.46809703626328,3.5269411605584,6,29,0,0,29,0,0,0,0,8,0,2,2,0,0,0,0,5,0,5,2,8,0,13,15,-0.652988855116515,0.267006802721088,0.0746621843107832,-0.248081841432225,0.292134831460674,0.831578947368421,-0.886326194398682,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.152,-1.028,"9:9","147/150","S:E:D",1.24373033542254,0.0337889223820885,0.585951699076682,2.12258166907334,1.02578380758221,10.8758695145359,0.540145217509122,0.0400825565026472,1.39704458655237,0.867177455332643,12.7072994899286,0.0603790832350862,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR2515950","ERR2515950","lineage4.1.1.1","za","South Africa","pnca_p.asp136gly","A","T","ASP","DA136","pnca_complex.pdb"
|
|
"D136G","L2","PZA","D","D136",136,"G",0,"XDR","DM","hydrophilic","hydrophobic","acidic","neutral","neg","non-polar",6.179,-2.578,0.314,2.04991,-1.455,0.52,79,85,-1.076,9,9,6,0.0310880829015544,"loop",-2.46666666666667,5.37,0.0008624407072013,3.46852810205801,3.46852813512699,3.46809703626328,3.5269411605584,6,29,0,0,29,0,0,0,0,8,0,2,2,0,0,0,0,5,0,5,2,8,0,13,15,-0.652988855116515,0.267006802721088,0.0746621843107832,-0.248081841432225,0.292134831460674,0.831578947368421,-0.886326194398682,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.152,-1.028,"9:9","147/150","S:E:D",1.24373033542254,0.0337889223820885,0.585951699076682,2.12258166907334,1.02578380758221,10.8758695145359,0.540145217509122,0.0400825565026472,1.39704458655237,0.867177455332643,12.7072994899286,0.0603790832350862,"lineage2","dr_mutations_pyrazinamide","GLY",0,"0951K-sc-2011-09-07T13:19:47Z-1276521,ERR067674","ERR067674","lineage2.2.1","ru","Russia,Samara","pnca_p.asp136gly","A","T","ASP","DA136","pnca_complex.pdb"
|
|
"D136G","L2","PZA","D","D136",136,"G",NA,"MDR","DM","hydrophilic","hydrophobic","acidic","neutral","neg","non-polar",6.179,-2.578,0.314,2.04991,-1.455,0.52,79,85,-1.076,9,9,6,0.0310880829015544,"loop",-2.46666666666667,5.37,0.0008624407072013,3.46852810205801,3.46852813512699,3.46809703626328,3.5269411605584,6,29,0,0,29,0,0,0,0,8,0,2,2,0,0,0,0,5,0,5,2,8,0,13,15,-0.652988855116515,0.267006802721088,0.0746621843107832,-0.248081841432225,0.292134831460674,0.831578947368421,-0.886326194398682,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.152,-1.028,"9:9","147/150","S:E:D",1.24373033542254,0.0337889223820885,0.585951699076682,2.12258166907334,1.02578380758221,10.8758695145359,0.540145217509122,0.0400825565026472,1.39704458655237,0.867177455332643,12.7072994899286,0.0603790832350862,"lineage2","dr_mutations_pyrazinamide","GLY",0,"SRR671837,BGI_GZ119","SRR671837","lineage2.2.1","cn","China","pnca_p.asp136gly","A","T","ASP","DA136","pnca_complex.pdb"
|
|
"D136G","L4","PZA","D","D136",136,"G",NA,"MDR","DM","hydrophilic","hydrophobic","acidic","neutral","neg","non-polar",6.179,-2.578,0.314,2.04991,-1.455,0.52,79,85,-1.076,9,9,6,0.0310880829015544,"loop",-2.46666666666667,5.37,0.0008624407072013,3.46852810205801,3.46852813512699,3.46809703626328,3.5269411605584,6,29,0,0,29,0,0,0,0,8,0,2,2,0,0,0,0,5,0,5,2,8,0,13,15,-0.652988855116515,0.267006802721088,0.0746621843107832,-0.248081841432225,0.292134831460674,0.831578947368421,-0.886326194398682,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.152,-1.028,"9:9","147/150","S:E:D",1.24373033542254,0.0337889223820885,0.585951699076682,2.12258166907334,1.02578380758221,10.8758695145359,0.540145217509122,0.0400825565026472,1.39704458655237,0.867177455332643,12.7072994899286,0.0603790832350862,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR2510194","ERR2510194","lineage4.3.3","pe","Peru","pnca_p.asp136gly","A","T","ASP","DA136","pnca_complex.pdb"
|
|
"D136G","L4","PZA","D","D136",136,"G",NA,"MDR","DM","hydrophilic","hydrophobic","acidic","neutral","neg","non-polar",6.179,-2.578,0.314,2.04991,-1.455,0.52,79,85,-1.076,9,9,6,0.0310880829015544,"loop",-2.46666666666667,5.37,0.0008624407072013,3.46852810205801,3.46852813512699,3.46809703626328,3.5269411605584,6,29,0,0,29,0,0,0,0,8,0,2,2,0,0,0,0,5,0,5,2,8,0,13,15,-0.652988855116515,0.267006802721088,0.0746621843107832,-0.248081841432225,0.292134831460674,0.831578947368421,-0.886326194398682,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.152,-1.028,"9:9","147/150","S:E:D",1.24373033542254,0.0337889223820885,0.585951699076682,2.12258166907334,1.02578380758221,10.8758695145359,0.540145217509122,0.0400825565026472,1.39704458655237,0.867177455332643,12.7072994899286,0.0603790832350862,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR1199131","ERR1199131","lineage4.6.1.1","ug","Uganda","pnca_p.asp136gly","A","T","ASP","DA136","pnca_complex.pdb"
|
|
"D136G","L2","PZA","D","D136",136,"G",0,"MDR","DM","hydrophilic","hydrophobic","acidic","neutral","neg","non-polar",6.179,-2.578,0.314,2.04991,-1.455,0.52,79,85,-1.076,9,9,6,0.0310880829015544,"loop",-2.46666666666667,5.37,0.0008624407072013,3.46852810205801,3.46852813512699,3.46809703626328,3.5269411605584,6,29,0,0,29,0,0,0,0,8,0,2,2,0,0,0,0,5,0,5,2,8,0,13,15,-0.652988855116515,0.267006802721088,0.0746621843107832,-0.248081841432225,0.292134831460674,0.831578947368421,-0.886326194398682,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.152,-1.028,"9:9","147/150","S:E:D",1.24373033542254,0.0337889223820885,0.585951699076682,2.12258166907334,1.02578380758221,10.8758695145359,0.540145217509122,0.0400825565026472,1.39704458655237,0.867177455332643,12.7072994899286,0.0603790832350862,"lineage2","dr_mutations_pyrazinamide","GLY",0,"ERR2516906","ERR2516906","lineage2.2.1.2","gb","UK","pnca_p.asp136gly","A","T","ASP","DA136","pnca_complex.pdb"
|
|
"D136G","L4","PZA","D","D136",136,"G",NA,"MDR","DM","hydrophilic","hydrophobic","acidic","neutral","neg","non-polar",6.179,-2.578,0.314,2.04991,-1.455,0.52,79,85,-1.076,9,9,6,0.0310880829015544,"loop",-2.46666666666667,5.37,0.0008624407072013,3.46852810205801,3.46852813512699,3.46809703626328,3.5269411605584,6,29,0,0,29,0,0,0,0,8,0,2,2,0,0,0,0,5,0,5,2,8,0,13,15,-0.652988855116515,0.267006802721088,0.0746621843107832,-0.248081841432225,0.292134831460674,0.831578947368421,-0.886326194398682,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.152,-1.028,"9:9","147/150","S:E:D",1.24373033542254,0.0337889223820885,0.585951699076682,2.12258166907334,1.02578380758221,10.8758695145359,0.540145217509122,0.0400825565026472,1.39704458655237,0.867177455332643,12.7072994899286,0.0603790832350862,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR779890","ERR779890","lineage4.3.3","pe","","pnca_p.asp136gly","A","T","ASP","DA136","pnca_complex.pdb"
|
|
"D136G","L2","PZA","D","D136",136,"G",NA,"Pre-XDR","DM","hydrophilic","hydrophobic","acidic","neutral","neg","non-polar",6.179,-2.578,0.314,2.04991,-1.455,0.52,79,85,-1.076,9,9,6,0.0310880829015544,"loop",-2.46666666666667,5.37,0.0008624407072013,3.46852810205801,3.46852813512699,3.46809703626328,3.5269411605584,6,29,0,0,29,0,0,0,0,8,0,2,2,0,0,0,0,5,0,5,2,8,0,13,15,-0.652988855116515,0.267006802721088,0.0746621843107832,-0.248081841432225,0.292134831460674,0.831578947368421,-0.886326194398682,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.152,-1.028,"9:9","147/150","S:E:D",1.24373033542254,0.0337889223820885,0.585951699076682,2.12258166907334,1.02578380758221,10.8758695145359,0.540145217509122,0.0400825565026472,1.39704458655237,0.867177455332643,12.7072994899286,0.0603790832350862,"lineage2","dr_mutations_pyrazinamide","GLY",0,"SAMN03653201,SRS935937","SRR2024880","lineage2.2.1","cn","China","pnca_p.asp136gly","A","T","ASP","DA136","pnca_complex.pdb"
|
|
"D136G","L2","PZA","D","D136",136,"G",NA,"MDR","DM","hydrophilic","hydrophobic","acidic","neutral","neg","non-polar",6.179,-2.578,0.314,2.04991,-1.455,0.52,79,85,-1.076,9,9,6,0.0310880829015544,"loop",-2.46666666666667,5.37,0.0008624407072013,3.46852810205801,3.46852813512699,3.46809703626328,3.5269411605584,6,29,0,0,29,0,0,0,0,8,0,2,2,0,0,0,0,5,0,5,2,8,0,13,15,-0.652988855116515,0.267006802721088,0.0746621843107832,-0.248081841432225,0.292134831460674,0.831578947368421,-0.886326194398682,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.152,-1.028,"9:9","147/150","S:E:D",1.24373033542254,0.0337889223820885,0.585951699076682,2.12258166907334,1.02578380758221,10.8758695145359,0.540145217509122,0.0400825565026472,1.39704458655237,0.867177455332643,12.7072994899286,0.0603790832350862,"lineage2","dr_mutations_pyrazinamide","GLY",0,"ERR2512596","ERR2512596","lineage2.2.1.2","gb","UK","pnca_p.asp136gly","A","T","ASP","DA136","pnca_complex.pdb"
|
|
"D136G","L4","PZA","D","D136",136,"G",NA,"MDR","DM","hydrophilic","hydrophobic","acidic","neutral","neg","non-polar",6.179,-2.578,0.314,2.04991,-1.455,0.52,79,85,-1.076,9,9,6,0.0310880829015544,"loop",-2.46666666666667,5.37,0.0008624407072013,3.46852810205801,3.46852813512699,3.46809703626328,3.5269411605584,6,29,0,0,29,0,0,0,0,8,0,2,2,0,0,0,0,5,0,5,2,8,0,13,15,-0.652988855116515,0.267006802721088,0.0746621843107832,-0.248081841432225,0.292134831460674,0.831578947368421,-0.886326194398682,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.152,-1.028,"9:9","147/150","S:E:D",1.24373033542254,0.0337889223820885,0.585951699076682,2.12258166907334,1.02578380758221,10.8758695145359,0.540145217509122,0.0400825565026472,1.39704458655237,0.867177455332643,12.7072994899286,0.0603790832350862,"lineage4","dr_mutations_pyrazinamide","GLY",0,"SRR7517834","SRR7517834","lineage4.3.3","pe","Peru","pnca_p.asp136gly","A","T","ASP","DA136","pnca_complex.pdb"
|
|
"D136G","L2","PZA","D","D136",136,"G",NA,"MDR","DM","hydrophilic","hydrophobic","acidic","neutral","neg","non-polar",6.179,-2.578,0.314,2.04991,-1.455,0.52,79,85,-1.076,9,9,6,0.0310880829015544,"loop",-2.46666666666667,5.37,0.0008624407072013,3.46852810205801,3.46852813512699,3.46809703626328,3.5269411605584,6,29,0,0,29,0,0,0,0,8,0,2,2,0,0,0,0,5,0,5,2,8,0,13,15,-0.652988855116515,0.267006802721088,0.0746621843107832,-0.248081841432225,0.292134831460674,0.831578947368421,-0.886326194398682,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.152,-1.028,"9:9","147/150","S:E:D",1.24373033542254,0.0337889223820885,0.585951699076682,2.12258166907334,1.02578380758221,10.8758695145359,0.540145217509122,0.0400825565026472,1.39704458655237,0.867177455332643,12.7072994899286,0.0603790832350862,"lineage2","dr_mutations_pyrazinamide","GLY",0,"ERR2513295","ERR2513295","lineage2.2.1.2","gb","UK","pnca_p.asp136gly","A","T","ASP","DA136","pnca_complex.pdb"
|
|
"D136G","L2","PZA","D","D136",136,"G",1,"Pre-XDR","DM","hydrophilic","hydrophobic","acidic","neutral","neg","non-polar",6.179,-2.578,0.314,2.04991,-1.455,0.52,79,85,-1.076,9,9,6,0.0310880829015544,"loop",-2.46666666666667,5.37,0.0008624407072013,3.46852810205801,3.46852813512699,3.46809703626328,3.5269411605584,6,29,0,0,29,0,0,0,0,8,0,2,2,0,0,0,0,5,0,5,2,8,0,13,15,-0.652988855116515,0.267006802721088,0.0746621843107832,-0.248081841432225,0.292134831460674,0.831578947368421,-0.886326194398682,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.152,-1.028,"9:9","147/150","S:E:D",1.24373033542254,0.0337889223820885,0.585951699076682,2.12258166907334,1.02578380758221,10.8758695145359,0.540145217509122,0.0400825565026472,1.39704458655237,0.867177455332643,12.7072994899286,0.0603790832350862,"lineage2","dr_mutations_pyrazinamide","GLY",0,"ERR2041787","ERR2041787","lineage2.2.1","rs","Serbia","pnca_p.asp136gly","A","T","ASP","DA136","pnca_complex.pdb"
|
|
"D136G","L2","PZA","D","D136",136,"G",NA,"Pre-XDR","DM","hydrophilic","hydrophobic","acidic","neutral","neg","non-polar",6.179,-2.578,0.314,2.04991,-1.455,0.52,79,85,-1.076,9,9,6,0.0310880829015544,"loop",-2.46666666666667,5.37,0.0008624407072013,3.46852810205801,3.46852813512699,3.46809703626328,3.5269411605584,6,29,0,0,29,0,0,0,0,8,0,2,2,0,0,0,0,5,0,5,2,8,0,13,15,-0.652988855116515,0.267006802721088,0.0746621843107832,-0.248081841432225,0.292134831460674,0.831578947368421,-0.886326194398682,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.152,-1.028,"9:9","147/150","S:E:D",1.24373033542254,0.0337889223820885,0.585951699076682,2.12258166907334,1.02578380758221,10.8758695145359,0.540145217509122,0.0400825565026472,1.39704458655237,0.867177455332643,12.7072994899286,0.0603790832350862,"lineage2","dr_mutations_pyrazinamide","GLY",0,"SRR5709799,SAMN07236260","SRR5709799","lineage2.2.1","th","Thailand","pnca_p.asp136gly","A","T","ASP","DA136","pnca_complex.pdb"
|
|
"D136G","L2","PZA","D","D136",136,"G",NA,"Pre-XDR","DM","hydrophilic","hydrophobic","acidic","neutral","neg","non-polar",6.179,-2.578,0.314,2.04991,-1.455,0.52,79,85,-1.076,9,9,6,0.0310880829015544,"loop",-2.46666666666667,5.37,0.0008624407072013,3.46852810205801,3.46852813512699,3.46809703626328,3.5269411605584,6,29,0,0,29,0,0,0,0,8,0,2,2,0,0,0,0,5,0,5,2,8,0,13,15,-0.652988855116515,0.267006802721088,0.0746621843107832,-0.248081841432225,0.292134831460674,0.831578947368421,-0.886326194398682,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.152,-1.028,"9:9","147/150","S:E:D",1.24373033542254,0.0337889223820885,0.585951699076682,2.12258166907334,1.02578380758221,10.8758695145359,0.540145217509122,0.0400825565026472,1.39704458655237,0.867177455332643,12.7072994899286,0.0603790832350862,"lineage2","dr_mutations_pyrazinamide","GLY",0,"SRS935947,SAMN03653221","SRR2024915","lineage2.2.1","cn","China","pnca_p.asp136gly","A","T","ASP","DA136","pnca_complex.pdb"
|
|
"D136G","L2","PZA","D","D136",136,"G",0,"MDR","DM","hydrophilic","hydrophobic","acidic","neutral","neg","non-polar",6.179,-2.578,0.314,2.04991,-1.455,0.52,79,85,-1.076,9,9,6,0.0310880829015544,"loop",-2.46666666666667,5.37,0.0008624407072013,3.46852810205801,3.46852813512699,3.46809703626328,3.5269411605584,6,29,0,0,29,0,0,0,0,8,0,2,2,0,0,0,0,5,0,5,2,8,0,13,15,-0.652988855116515,0.267006802721088,0.0746621843107832,-0.248081841432225,0.292134831460674,0.831578947368421,-0.886326194398682,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.152,-1.028,"9:9","147/150","S:E:D",1.24373033542254,0.0337889223820885,0.585951699076682,2.12258166907334,1.02578380758221,10.8758695145359,0.540145217509122,0.0400825565026472,1.39704458655237,0.867177455332643,12.7072994899286,0.0603790832350862,"lineage2","dr_mutations_pyrazinamide","GLY",0,"ERR2516936","ERR2516936","lineage2.2.1.2","gb","UK","pnca_p.asp136gly","A","T","ASP","DA136","pnca_complex.pdb"
|
|
"D136G","L2","PZA","D","D136",136,"G",1,"Pre-XDR","DM","hydrophilic","hydrophobic","acidic","neutral","neg","non-polar",6.179,-2.578,0.314,2.04991,-1.455,0.52,79,85,-1.076,9,9,6,0.0310880829015544,"loop",-2.46666666666667,5.37,0.0008624407072013,3.46852810205801,3.46852813512699,3.46809703626328,3.5269411605584,6,29,0,0,29,0,0,0,0,8,0,2,2,0,0,0,0,5,0,5,2,8,0,13,15,-0.652988855116515,0.267006802721088,0.0746621843107832,-0.248081841432225,0.292134831460674,0.831578947368421,-0.886326194398682,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.152,-1.028,"9:9","147/150","S:E:D",1.24373033542254,0.0337889223820885,0.585951699076682,2.12258166907334,1.02578380758221,10.8758695145359,0.540145217509122,0.0400825565026472,1.39704458655237,0.867177455332643,12.7072994899286,0.0603790832350862,"lineage2","dr_mutations_pyrazinamide","GLY",0,"SAMN10961359","SRR8651600","lineage2.2.1","cn","China:Wenzhou","pnca_p.asp136gly","A","T","ASP","DA136","pnca_complex.pdb"
|
|
"D136G","L2","PZA","D","D136",136,"G",NA,"MDR","DM","hydrophilic","hydrophobic","acidic","neutral","neg","non-polar",6.179,-2.578,0.314,2.04991,-1.455,0.52,79,85,-1.076,9,9,6,0.0310880829015544,"loop",-2.46666666666667,5.37,0.0008624407072013,3.46852810205801,3.46852813512699,3.46809703626328,3.5269411605584,6,29,0,0,29,0,0,0,0,8,0,2,2,0,0,0,0,5,0,5,2,8,0,13,15,-0.652988855116515,0.267006802721088,0.0746621843107832,-0.248081841432225,0.292134831460674,0.831578947368421,-0.886326194398682,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.152,-1.028,"9:9","147/150","S:E:D",1.24373033542254,0.0337889223820885,0.585951699076682,2.12258166907334,1.02578380758221,10.8758695145359,0.540145217509122,0.0400825565026472,1.39704458655237,0.867177455332643,12.7072994899286,0.0603790832350862,"lineage2","dr_mutations_pyrazinamide","GLY",0,"OU18-FMR64","SRR5341252","lineage2.2.1.2","in","India","pnca_p.asp136gly","A","T","ASP","DA136","pnca_complex.pdb"
|
|
"D136G","L2","PZA","D","D136",136,"G",1,"Pre-XDR","DM","hydrophilic","hydrophobic","acidic","neutral","neg","non-polar",6.179,-2.578,0.314,2.04991,-1.455,0.52,79,85,-1.076,9,9,6,0.0310880829015544,"loop",-2.46666666666667,5.37,0.0008624407072013,3.46852810205801,3.46852813512699,3.46809703626328,3.5269411605584,6,29,0,0,29,0,0,0,0,8,0,2,2,0,0,0,0,5,0,5,2,8,0,13,15,-0.652988855116515,0.267006802721088,0.0746621843107832,-0.248081841432225,0.292134831460674,0.831578947368421,-0.886326194398682,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.152,-1.028,"9:9","147/150","S:E:D",1.24373033542254,0.0337889223820885,0.585951699076682,2.12258166907334,1.02578380758221,10.8758695145359,0.540145217509122,0.0400825565026472,1.39704458655237,0.867177455332643,12.7072994899286,0.0603790832350862,"lineage2","dr_mutations_pyrazinamide","GLY",0,"MDR_5169","SRR6824470","lineage2.2.1","cn","China: Huimin District, Huhhot City, Inner Mongolia Province","pnca_p.asp136gly","A","T","ASP","DA136","pnca_complex.pdb"
|
|
"D136N","L2","PZA","D","D136",136,"N",NA,"Pre-MDR","DM","hydrophilic","hydrophilic","acidic","neutral","neg","polar",6.179,-1.58,0.216,0.961088,-1.377,0.48,79,85,-1.076,9,9,6,0.0310880829015544,"loop",-2.46666666666667,5.37,0.0005030904125341,3.63983585858586,3.63983585304829,3.63936365398778,1.71237896478786,0,29,0,0,29,0,0,0,0,4,0,0,2,0,0,0,0,-5,0,3,-9,4,0,2,-4,-0.400202634245187,0.183673469387755,0.0350049169938592,-0.234782608695652,0.269662921348315,0.831578947368421,-0.886326194398682,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.152,-1.028,"9:9","147/150","S:E:D",1.29193858531542,0.0908665432562708,0.764078977125449,1.69084430273928,0.716519099632433,16.5222710930887,0.561081799221107,0.101883776579733,0.99189496518722,0.532738756693438,21.52594647947,0.190677002690395,"lineage2","dr_mutations_pyrazinamide","ASN",0,"SRR5073892","SRR5073892","lineage2.2.1.1","vn","Vietnam","pnca_p.asp136asn","A","T","ASP","DA136","pnca_complex.pdb"
|
|
"D136N","L2","PZA","D","D136",136,"N",NA,"Pre-XDR","DM","hydrophilic","hydrophilic","acidic","neutral","neg","polar",6.179,-1.58,0.216,0.961088,-1.377,0.48,79,85,-1.076,9,9,6,0.0310880829015544,"loop",-2.46666666666667,5.37,0.0005030904125341,3.63983585858586,3.63983585304829,3.63936365398778,1.71237896478786,0,29,0,0,29,0,0,0,0,4,0,0,2,0,0,0,0,-5,0,3,-9,4,0,2,-4,-0.400202634245187,0.183673469387755,0.0350049169938592,-0.234782608695652,0.269662921348315,0.831578947368421,-0.886326194398682,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.152,-1.028,"9:9","147/150","S:E:D",1.29193858531542,0.0908665432562708,0.764078977125449,1.69084430273928,0.716519099632433,16.5222710930887,0.561081799221107,0.101883776579733,0.99189496518722,0.532738756693438,21.52594647947,0.190677002690395,"lineage2","dr_mutations_pyrazinamide","ASN",0,"SRS797074","SRR1723578","lineage2.2.1","cn","China:InnerMongolia","pnca_p.asp136asn","A","T","ASP","DA136","pnca_complex.pdb"
|
|
"D136N","L2","PZA","D","D136",136,"N",0,"MDR","DM","hydrophilic","hydrophilic","acidic","neutral","neg","polar",6.179,-1.58,0.216,0.961088,-1.377,0.48,79,85,-1.076,9,9,6,0.0310880829015544,"loop",-2.46666666666667,5.37,0.0005030904125341,3.63983585858586,3.63983585304829,3.63936365398778,1.71237896478786,0,29,0,0,29,0,0,0,0,4,0,0,2,0,0,0,0,-5,0,3,-9,4,0,2,-4,-0.400202634245187,0.183673469387755,0.0350049169938592,-0.234782608695652,0.269662921348315,0.831578947368421,-0.886326194398682,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.152,-1.028,"9:9","147/150","S:E:D",1.29193858531542,0.0908665432562708,0.764078977125449,1.69084430273928,0.716519099632433,16.5222710930887,0.561081799221107,0.101883776579733,0.99189496518722,0.532738756693438,21.52594647947,0.190677002690395,"lineage2","dr_mutations_pyrazinamide","ASN",0,"SRR6339662","SRR6339662","lineage2.2.1","au","Australia","pnca_p.asp136asn","A","T","ASP","DA136","pnca_complex.pdb"
|
|
"D136N","L2","PZA","D","D136",136,"N",1,"Pre-XDR","DM","hydrophilic","hydrophilic","acidic","neutral","neg","polar",6.179,-1.58,0.216,0.961088,-1.377,0.48,79,85,-1.076,9,9,6,0.0310880829015544,"loop",-2.46666666666667,5.37,0.0005030904125341,3.63983585858586,3.63983585304829,3.63936365398778,1.71237896478786,0,29,0,0,29,0,0,0,0,4,0,0,2,0,0,0,0,-5,0,3,-9,4,0,2,-4,-0.400202634245187,0.183673469387755,0.0350049169938592,-0.234782608695652,0.269662921348315,0.831578947368421,-0.886326194398682,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.152,-1.028,"9:9","147/150","S:E:D",1.29193858531542,0.0908665432562708,0.764078977125449,1.69084430273928,0.716519099632433,16.5222710930887,0.561081799221107,0.101883776579733,0.99189496518722,0.532738756693438,21.52594647947,0.190677002690395,"lineage2","dr_mutations_pyrazinamide","ASN",0,"MDR_5162","SRR6824474","lineage2.2.1","cn","China: Huimin District, Huhhot City, Inner Mongolia Province","pnca_p.asp136asn","A","T","ASP","DA136","pnca_complex.pdb"
|
|
"D136N","L4","PZA","D","D136",136,"N",NA,"Other","DM","hydrophilic","hydrophilic","acidic","neutral","neg","polar",6.179,-1.58,0.216,0.961088,-1.377,0.48,79,85,-1.076,9,9,6,0.0310880829015544,"loop",-2.46666666666667,5.37,0.0005030904125341,3.63983585858586,3.63983585304829,3.63936365398778,1.71237896478786,0,29,0,0,29,0,0,0,0,4,0,0,2,0,0,0,0,-5,0,3,-9,4,0,2,-4,-0.400202634245187,0.183673469387755,0.0350049169938592,-0.234782608695652,0.269662921348315,0.831578947368421,-0.886326194398682,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.152,-1.028,"9:9","147/150","S:E:D",1.29193858531542,0.0908665432562708,0.764078977125449,1.69084430273928,0.716519099632433,16.5222710930887,0.561081799221107,0.101883776579733,0.99189496518722,0.532738756693438,21.52594647947,0.190677002690395,"lineage4","dr_mutations_pyrazinamide","ASN",0,"ERR2514962","ERR2514962","lineage4.4","gb","UK","pnca_p.asp136asn","A","T","ASP","DA136","pnca_complex.pdb"
|
|
"D136N","L4","PZA","D","D136",136,"N",NA,"Other","DM","hydrophilic","hydrophilic","acidic","neutral","neg","polar",6.179,-1.58,0.216,0.961088,-1.377,0.48,79,85,-1.076,9,9,6,0.0310880829015544,"loop",-2.46666666666667,5.37,0.0005030904125341,3.63983585858586,3.63983585304829,3.63936365398778,1.71237896478786,0,29,0,0,29,0,0,0,0,4,0,0,2,0,0,0,0,-5,0,3,-9,4,0,2,-4,-0.400202634245187,0.183673469387755,0.0350049169938592,-0.234782608695652,0.269662921348315,0.831578947368421,-0.886326194398682,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.152,-1.028,"9:9","147/150","S:E:D",1.29193858531542,0.0908665432562708,0.764078977125449,1.69084430273928,0.716519099632433,16.5222710930887,0.561081799221107,0.101883776579733,0.99189496518722,0.532738756693438,21.52594647947,0.190677002690395,"lineage4","dr_mutations_pyrazinamide","ASN",0,"ERR2512642","ERR2512642","lineage4.4","gb","UK","pnca_p.asp136asn","A","T","ASP","DA136","pnca_complex.pdb"
|
|
"D136N","L2","PZA","D","D136",136,"N",NA,"MDR","DM","hydrophilic","hydrophilic","acidic","neutral","neg","polar",6.179,-1.58,0.216,0.961088,-1.377,0.48,79,85,-1.076,9,9,6,0.0310880829015544,"loop",-2.46666666666667,5.37,0.0005030904125341,3.63983585858586,3.63983585304829,3.63936365398778,1.71237896478786,0,29,0,0,29,0,0,0,0,4,0,0,2,0,0,0,0,-5,0,3,-9,4,0,2,-4,-0.400202634245187,0.183673469387755,0.0350049169938592,-0.234782608695652,0.269662921348315,0.831578947368421,-0.886326194398682,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.152,-1.028,"9:9","147/150","S:E:D",1.29193858531542,0.0908665432562708,0.764078977125449,1.69084430273928,0.716519099632433,16.5222710930887,0.561081799221107,0.101883776579733,0.99189496518722,0.532738756693438,21.52594647947,0.190677002690395,"lineage2","dr_mutations_pyrazinamide","ASN",0,"SRS797035","SRR1723534_SRR1723535","lineage2.2.1","cn","China:Jiangxi","pnca_p.asp136asn","A","T","ASP","DA136","pnca_complex.pdb"
|
|
"D136N","L4","PZA","D","D136",136,"N",1,"Other","DM","hydrophilic","hydrophilic","acidic","neutral","neg","polar",6.179,-1.58,0.216,0.961088,-1.377,0.48,79,85,-1.076,9,9,6,0.0310880829015544,"loop",-2.46666666666667,5.37,0.0005030904125341,3.63983585858586,3.63983585304829,3.63936365398778,1.71237896478786,0,29,0,0,29,0,0,0,0,4,0,0,2,0,0,0,0,-5,0,3,-9,4,0,2,-4,-0.400202634245187,0.183673469387755,0.0350049169938592,-0.234782608695652,0.269662921348315,0.831578947368421,-0.886326194398682,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.152,-1.028,"9:9","147/150","S:E:D",1.29193858531542,0.0908665432562708,0.764078977125449,1.69084430273928,0.716519099632433,16.5222710930887,0.561081799221107,0.101883776579733,0.99189496518722,0.532738756693438,21.52594647947,0.190677002690395,"lineage4","dr_mutations_pyrazinamide","ASN",0,"SAMN03648509,SRR2101262","SRR2101262","lineage4.4","","","pnca_p.asp136asn","A","T","ASP","DA136","pnca_complex.pdb"
|
|
"D136N","L2","PZA","D","D136",136,"N",1,"MDR","DM","hydrophilic","hydrophilic","acidic","neutral","neg","polar",6.179,-1.58,0.216,0.961088,-1.377,0.48,79,85,-1.076,9,9,6,0.0310880829015544,"loop",-2.46666666666667,5.37,0.0005030904125341,3.63983585858586,3.63983585304829,3.63936365398778,1.71237896478786,0,29,0,0,29,0,0,0,0,4,0,0,2,0,0,0,0,-5,0,3,-9,4,0,2,-4,-0.400202634245187,0.183673469387755,0.0350049169938592,-0.234782608695652,0.269662921348315,0.831578947368421,-0.886326194398682,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.152,-1.028,"9:9","147/150","S:E:D",1.29193858531542,0.0908665432562708,0.764078977125449,1.69084430273928,0.716519099632433,16.5222710930887,0.561081799221107,0.101883776579733,0.99189496518722,0.532738756693438,21.52594647947,0.190677002690395,"lineage2","dr_mutations_pyrazinamide","ASN",0,"MDR_14165","SRR6824677","lineage2.2.1","cn","China: Dayu County, Ganzhou City, Jiangxi Province","pnca_p.asp136asn","A","T","ASP","DA136","pnca_complex.pdb"
|
|
"D136N","L4","PZA","D","D136",136,"N",0,"Other","DM","hydrophilic","hydrophilic","acidic","neutral","neg","polar",6.179,-1.58,0.216,0.961088,-1.377,0.48,79,85,-1.076,9,9,6,0.0310880829015544,"loop",-2.46666666666667,5.37,0.0005030904125341,3.63983585858586,3.63983585304829,3.63936365398778,1.71237896478786,0,29,0,0,29,0,0,0,0,4,0,0,2,0,0,0,0,-5,0,3,-9,4,0,2,-4,-0.400202634245187,0.183673469387755,0.0350049169938592,-0.234782608695652,0.269662921348315,0.831578947368421,-0.886326194398682,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.152,-1.028,"9:9","147/150","S:E:D",1.29193858531542,0.0908665432562708,0.764078977125449,1.69084430273928,0.716519099632433,16.5222710930887,0.561081799221107,0.101883776579733,0.99189496518722,0.532738756693438,21.52594647947,0.190677002690395,"lineage4","dr_mutations_pyrazinamide","ASN",0,"SAMN03647228","SRR2100055","lineage4.4","","","pnca_p.asp136asn","A","T","ASP","DA136","pnca_complex.pdb"
|
|
"D136N","L4","PZA","D","D136",136,"N",0,"Other","DM","hydrophilic","hydrophilic","acidic","neutral","neg","polar",6.179,-1.58,0.216,0.961088,-1.377,0.48,79,85,-1.076,9,9,6,0.0310880829015544,"loop",-2.46666666666667,5.37,0.0005030904125341,3.63983585858586,3.63983585304829,3.63936365398778,1.71237896478786,0,29,0,0,29,0,0,0,0,4,0,0,2,0,0,0,0,-5,0,3,-9,4,0,2,-4,-0.400202634245187,0.183673469387755,0.0350049169938592,-0.234782608695652,0.269662921348315,0.831578947368421,-0.886326194398682,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.152,-1.028,"9:9","147/150","S:E:D",1.29193858531542,0.0908665432562708,0.764078977125449,1.69084430273928,0.716519099632433,16.5222710930887,0.561081799221107,0.101883776579733,0.99189496518722,0.532738756693438,21.52594647947,0.190677002690395,"lineage4","dr_mutations_pyrazinamide","ASN",0,"ERR2514359","ERR2514359","lineage4.4","gb","UK","pnca_p.asp136asn","A","T","ASP","DA136","pnca_complex.pdb"
|
|
"D136N","L4","PZA","D","D136",136,"N",0,"Other","DM","hydrophilic","hydrophilic","acidic","neutral","neg","polar",6.179,-1.58,0.216,0.961088,-1.377,0.48,79,85,-1.076,9,9,6,0.0310880829015544,"loop",-2.46666666666667,5.37,0.0005030904125341,3.63983585858586,3.63983585304829,3.63936365398778,1.71237896478786,0,29,0,0,29,0,0,0,0,4,0,0,2,0,0,0,0,-5,0,3,-9,4,0,2,-4,-0.400202634245187,0.183673469387755,0.0350049169938592,-0.234782608695652,0.269662921348315,0.831578947368421,-0.886326194398682,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-1.152,-1.028,"9:9","147/150","S:E:D",1.29193858531542,0.0908665432562708,0.764078977125449,1.69084430273928,0.716519099632433,16.5222710930887,0.561081799221107,0.101883776579733,0.99189496518722,0.532738756693438,21.52594647947,0.190677002690395,"lineage4","dr_mutations_pyrazinamide","ASN",0,"SRR2099928,SAMN03647101","SRR2099928","lineage4.4","","","pnca_p.asp136asn","A","T","ASP","DA136","pnca_complex.pdb"
|
|
"D136Y","L4","PZA","D","D136",136,"Y",NA,"MDR","DM","hydrophilic","hydrophobic","acidic","neutral","neg","polar",6.179,-1.662,-0.96,6.12929,-1.07,-0.23,86,91,-1.076,9,9,6,0.0310880829015544,"loop",-2.46666666666667,5.37,0.0002156101768003,29.1287878787879,511969.848429002,Inf,9.2872640727157,-32,25,0,0,25,0,0,0,0,6,0,2,4,0,0,0,0,-6,0,-4,-4,-2,0,2,-2,-0.4209726443769,-0.248062015503876,0.223242083639887,-0.182438192668372,-0.0602094240837696,0.905263157894737,-0.886326194398682,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.152,-1.028,"9:9","147/150","S:E:D",13.1460210125005,0.907969111549614,113.719344731947,0.115600569485232,0.183926936277317,NA,1.4643224129316,0.0049931328456149,2.3016268790981,2.00455510251839,Inf,0.0023075254069185,"lineage4","dr_mutations_pyrazinamide","TYR",0,"ERR2510215","ERR2510215","lineage4.3.4.1","pe","Peru","pnca_p.asp136tyr","A","T","ASP","DA136","pnca_complex.pdb"
|
|
"D136Y","L4","PZA","D","D136",136,"Y",NA,"MDR","DM","hydrophilic","hydrophobic","acidic","neutral","neg","polar",6.179,-1.662,-0.96,6.12929,-1.07,-0.23,86,91,-1.076,9,9,6,0.0310880829015544,"loop",-2.46666666666667,5.37,0.0002156101768003,29.1287878787879,511969.848429002,Inf,9.2872640727157,-32,25,0,0,25,0,0,0,0,6,0,2,4,0,0,0,0,-6,0,-4,-4,-2,0,2,-2,-0.4209726443769,-0.248062015503876,0.223242083639887,-0.182438192668372,-0.0602094240837696,0.905263157894737,-0.886326194398682,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.152,-1.028,"9:9","147/150","S:E:D",13.1460210125005,0.907969111549614,113.719344731947,0.115600569485232,0.183926936277317,NA,1.4643224129316,0.0049931328456149,2.3016268790981,2.00455510251839,Inf,0.0023075254069185,"lineage4","dr_mutations_pyrazinamide","TYR",0,"ERR2510218","ERR2510218","lineage4.3.4.1","pe","Peru","pnca_p.asp136tyr","A","T","ASP","DA136","pnca_complex.pdb"
|
|
"D136Y","L2","PZA","D","D136",136,"Y",NA,"Pre-XDR","DM","hydrophilic","hydrophobic","acidic","neutral","neg","polar",6.179,-1.662,-0.96,6.12929,-1.07,-0.23,86,91,-1.076,9,9,6,0.0310880829015544,"loop",-2.46666666666667,5.37,0.0002156101768003,29.1287878787879,511969.848429002,Inf,9.2872640727157,-32,25,0,0,25,0,0,0,0,6,0,2,4,0,0,0,0,-6,0,-4,-4,-2,0,2,-2,-0.4209726443769,-0.248062015503876,0.223242083639887,-0.182438192668372,-0.0602094240837696,0.905263157894737,-0.886326194398682,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.152,-1.028,"9:9","147/150","S:E:D",13.1460210125005,0.907969111549614,113.719344731947,0.115600569485232,0.183926936277317,NA,1.4643224129316,0.0049931328456149,2.3016268790981,2.00455510251839,Inf,0.0023075254069185,"lineage2","dr_mutations_pyrazinamide","TYR",0,"ERR234656,2528Z-sc-2012-10-11T13:40:32Z-1494334","ERR234656","lineage2.2.1","ru","Russia","pnca_p.asp136tyr","A","T","ASP","DA136","pnca_complex.pdb"
|
|
"D136Y","L4","PZA","D","D136",136,"Y",NA,"MDR","DM","hydrophilic","hydrophobic","acidic","neutral","neg","polar",6.179,-1.662,-0.96,6.12929,-1.07,-0.23,86,91,-1.076,9,9,6,0.0310880829015544,"loop",-2.46666666666667,5.37,0.0002156101768003,29.1287878787879,511969.848429002,Inf,9.2872640727157,-32,25,0,0,25,0,0,0,0,6,0,2,4,0,0,0,0,-6,0,-4,-4,-2,0,2,-2,-0.4209726443769,-0.248062015503876,0.223242083639887,-0.182438192668372,-0.0602094240837696,0.905263157894737,-0.886326194398682,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.152,-1.028,"9:9","147/150","S:E:D",13.1460210125005,0.907969111549614,113.719344731947,0.115600569485232,0.183926936277317,NA,1.4643224129316,0.0049931328456149,2.3016268790981,2.00455510251839,Inf,0.0023075254069185,"lineage4","dr_mutations_pyrazinamide","TYR",0,"ERR779874","ERR779874","lineage4.3.4.1","pe","","pnca_p.asp136tyr","A","T","ASP","DA136","pnca_complex.pdb"
|
|
"D136Y","L2","PZA","D","D136",136,"Y",NA,"XDR","DM","hydrophilic","hydrophobic","acidic","neutral","neg","polar",6.179,-1.662,-0.96,6.12929,-1.07,-0.23,86,91,-1.076,9,9,6,0.0310880829015544,"loop",-2.46666666666667,5.37,0.0002156101768003,29.1287878787879,511969.848429002,Inf,9.2872640727157,-32,25,0,0,25,0,0,0,0,6,0,2,4,0,0,0,0,-6,0,-4,-4,-2,0,2,-2,-0.4209726443769,-0.248062015503876,0.223242083639887,-0.182438192668372,-0.0602094240837696,0.905263157894737,-0.886326194398682,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.152,-1.028,"9:9","147/150","S:E:D",13.1460210125005,0.907969111549614,113.719344731947,0.115600569485232,0.183926936277317,NA,1.4643224129316,0.0049931328456149,2.3016268790981,2.00455510251839,Inf,0.0023075254069185,"lineage2","dr_mutations_pyrazinamide","TYR",0,"ERR019857","ERR019857","lineage2.2.1","","UK","pnca_p.asp136tyr","A","T","ASP","DA136","pnca_complex.pdb"
|
|
"D136Y","L4","PZA","D","D136",136,"Y",NA,"MDR","DM","hydrophilic","hydrophobic","acidic","neutral","neg","polar",6.179,-1.662,-0.96,6.12929,-1.07,-0.23,86,91,-1.076,9,9,6,0.0310880829015544,"loop",-2.46666666666667,5.37,0.0002156101768003,29.1287878787879,511969.848429002,Inf,9.2872640727157,-32,25,0,0,25,0,0,0,0,6,0,2,4,0,0,0,0,-6,0,-4,-4,-2,0,2,-2,-0.4209726443769,-0.248062015503876,0.223242083639887,-0.182438192668372,-0.0602094240837696,0.905263157894737,-0.886326194398682,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.152,-1.028,"9:9","147/150","S:E:D",13.1460210125005,0.907969111549614,113.719344731947,0.115600569485232,0.183926936277317,NA,1.4643224129316,0.0049931328456149,2.3016268790981,2.00455510251839,Inf,0.0023075254069185,"lineage4","dr_mutations_pyrazinamide","TYR",0,"ERR779878","ERR779878","lineage4.3.4.1","pe","","pnca_p.asp136tyr","A","T","ASP","DA136","pnca_complex.pdb"
|
|
"D136Y","L3","PZA","D","D136",136,"Y",1,"Pre-XDR","DM","hydrophilic","hydrophobic","acidic","neutral","neg","polar",6.179,-1.662,-0.96,6.12929,-1.07,-0.23,86,91,-1.076,9,9,6,0.0310880829015544,"loop",-2.46666666666667,5.37,0.0002156101768003,29.1287878787879,511969.848429002,Inf,9.2872640727157,-32,25,0,0,25,0,0,0,0,6,0,2,4,0,0,0,0,-6,0,-4,-4,-2,0,2,-2,-0.4209726443769,-0.248062015503876,0.223242083639887,-0.182438192668372,-0.0602094240837696,0.905263157894737,-0.886326194398682,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.152,-1.028,"9:9","147/150","S:E:D",13.1460210125005,0.907969111549614,113.719344731947,0.115600569485232,0.183926936277317,NA,1.4643224129316,0.0049931328456149,2.3016268790981,2.00455510251839,Inf,0.0023075254069185,"lineage3","dr_mutations_pyrazinamide","TYR",0,"ERR2510246","ERR2510246","lineage3","pk","Pakistan","pnca_p.asp136tyr","A","T","ASP","DA136","pnca_complex.pdb"
|
|
"D136Y","L2","PZA","D","D136",136,"Y",NA,"XDR","DM","hydrophilic","hydrophobic","acidic","neutral","neg","polar",6.179,-1.662,-0.96,6.12929,-1.07,-0.23,86,91,-1.076,9,9,6,0.0310880829015544,"loop",-2.46666666666667,5.37,0.0002156101768003,29.1287878787879,511969.848429002,Inf,9.2872640727157,-32,25,0,0,25,0,0,0,0,6,0,2,4,0,0,0,0,-6,0,-4,-4,-2,0,2,-2,-0.4209726443769,-0.248062015503876,0.223242083639887,-0.182438192668372,-0.0602094240837696,0.905263157894737,-0.886326194398682,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.152,-1.028,"9:9","147/150","S:E:D",13.1460210125005,0.907969111549614,113.719344731947,0.115600569485232,0.183926936277317,NA,1.4643224129316,0.0049931328456149,2.3016268790981,2.00455510251839,Inf,0.0023075254069185,"lineage2","dr_mutations_pyrazinamide","TYR",0,"ERR228051","ERR228051","lineage2.2.1","ru","Russia","pnca_p.asp136tyr","A","T","ASP","DA136","pnca_complex.pdb"
|
|
"D136Y","L1","PZA","D","D136",136,"Y",NA,"MDR","DM","hydrophilic","hydrophobic","acidic","neutral","neg","polar",6.179,-1.662,-0.96,6.12929,-1.07,-0.23,86,91,-1.076,9,9,6,0.0310880829015544,"loop",-2.46666666666667,5.37,0.0002156101768003,29.1287878787879,511969.848429002,Inf,9.2872640727157,-32,25,0,0,25,0,0,0,0,6,0,2,4,0,0,0,0,-6,0,-4,-4,-2,0,2,-2,-0.4209726443769,-0.248062015503876,0.223242083639887,-0.182438192668372,-0.0602094240837696,0.905263157894737,-0.886326194398682,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.152,-1.028,"9:9","147/150","S:E:D",13.1460210125005,0.907969111549614,113.719344731947,0.115600569485232,0.183926936277317,NA,1.4643224129316,0.0049931328456149,2.3016268790981,2.00455510251839,Inf,0.0023075254069185,"lineage1","dr_mutations_pyrazinamide","TYR",0,"ERR3148194","ERR3148194","lineage1.2.1","mx","Mexico","pnca_p.asp136tyr","A","T","ASP","DA136","pnca_complex.pdb"
|
|
"D136Y","L2","PZA","D","D136",136,"Y",1,"XDR","DM","hydrophilic","hydrophobic","acidic","neutral","neg","polar",6.179,-1.662,-0.96,6.12929,-1.07,-0.23,86,91,-1.076,9,9,6,0.0310880829015544,"loop",-2.46666666666667,5.37,0.0002156101768003,29.1287878787879,511969.848429002,Inf,9.2872640727157,-32,25,0,0,25,0,0,0,0,6,0,2,4,0,0,0,0,-6,0,-4,-4,-2,0,2,-2,-0.4209726443769,-0.248062015503876,0.223242083639887,-0.182438192668372,-0.0602094240837696,0.905263157894737,-0.886326194398682,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.152,-1.028,"9:9","147/150","S:E:D",13.1460210125005,0.907969111549614,113.719344731947,0.115600569485232,0.183926936277317,NA,1.4643224129316,0.0049931328456149,2.3016268790981,2.00455510251839,Inf,0.0023075254069185,"lineage2","dr_mutations_pyrazinamide","TYR",0,"ERR228049,2243P-sc-2012-10-11T13:38:35Z-1494213","ERR228049","lineage2.2.1","ru","Russia,Samara","pnca_p.asp136tyr","A","T","ASP","DA136","pnca_complex.pdb"
|
|
"D136Y","L2","PZA","D","D136",136,"Y",1,"XDR","DM","hydrophilic","hydrophobic","acidic","neutral","neg","polar",6.179,-1.662,-0.96,6.12929,-1.07,-0.23,86,91,-1.076,9,9,6,0.0310880829015544,"loop",-2.46666666666667,5.37,0.0002156101768003,29.1287878787879,511969.848429002,Inf,9.2872640727157,-32,25,0,0,25,0,0,0,0,6,0,2,4,0,0,0,0,-6,0,-4,-4,-2,0,2,-2,-0.4209726443769,-0.248062015503876,0.223242083639887,-0.182438192668372,-0.0602094240837696,0.905263157894737,-0.886326194398682,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.152,-1.028,"9:9","147/150","S:E:D",13.1460210125005,0.907969111549614,113.719344731947,0.115600569485232,0.183926936277317,NA,1.4643224129316,0.0049931328456149,2.3016268790981,2.00455510251839,Inf,0.0023075254069185,"lineage2","dr_mutations_pyrazinamide","TYR",0,"ERR229929,2492K-sc-2012-10-11T13:39:10Z-1494248","ERR229929","lineage2.2.1","ru","Russia,Samara","pnca_p.asp136tyr","A","T","ASP","DA136","pnca_complex.pdb"
|
|
"H137N","L3","PZA","H","H137",137,"N",0,"MDR","OM","hydrophobic","hydrophilic","basic","neutral","pos","polar",3.419,-0.124,0.189,0.40144,-0.475,0.6,65,80,-0.415,7,7,84,0.375,"loop",-1.4,4.6,7.18700589334483e-05,2.42412778478352,0.0001249735077034,0,1.03410070803344e-29,14,3,0,0,3,0,0,0,0,0,0,0,0,0,0,0,0,-1,0,1,-1,4,0,2,2,-0.0314083080040526,0.160714285714286,0.0146213186284865,-0.0809889173060528,0.337078651685393,0.684210526315789,-0.341845140032949,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-0.615,-0.332,"7:6","147/150","Q:H:F:E:Y:I:V:W",-8.98740878149642,0.940032862253634,119.468044435493,-0.075228558598774,NA,4692673.51081254,0.384555509373631,1,0,0,188.544222231268,0.999999999999997,"lineage3","other_mutations_pyrazinamide","ASN",0,"ERR2516643","ERR2516643","lineage3","nl","Netherlands","pnca_p.his137asn","A","T","HIS","HA137","pnca_complex.pdb"
|
|
"H137N","L2","PZA","H","H137",137,"N",NA,"Pre-XDR","OM","hydrophobic","hydrophilic","basic","neutral","pos","polar",3.419,-0.124,0.189,0.40144,-0.475,0.6,65,80,-0.415,7,7,84,0.375,"loop",-1.4,4.6,7.18700589334483e-05,2.42412778478352,0.0001249735077034,0,1.03410070803344e-29,14,3,0,0,3,0,0,0,0,0,0,0,0,0,0,0,0,-1,0,1,-1,4,0,2,2,-0.0314083080040526,0.160714285714286,0.0146213186284865,-0.0809889173060528,0.337078651685393,0.684210526315789,-0.341845140032949,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-0.615,-0.332,"7:6","147/150","Q:H:F:E:Y:I:V:W",-8.98740878149642,0.940032862253634,119.468044435493,-0.075228558598774,NA,4692673.51081254,0.384555509373631,1,0,0,188.544222231268,0.999999999999997,"lineage2","other_mutations_pyrazinamide","ASN",0,"SAMN02419579","SRR1162483_SRR1181310_SRR1181122_SRR1159076","lineage2.2.1","by","Belarus","pnca_p.his137asn","A","T","HIS","HA137","pnca_complex.pdb"
|
|
"H137P","L4","PZA","H","H137",137,"P",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","basic","non-polar","pos","non-polar",3.419,-0.765,0.366,2.19045,-0.882,1.03,86,91,-0.415,7,7,84,0.375,"loop",-1.4,4.6,NA,NA,NA,NA,NA,34,3,0,0,3,0,0,0,0,2,0,2,0,0,0,0,0,0,4,-2,-4,2,0,-4,0,-0.193768996960486,0.311224489795918,0.0797809570291159,-0.150383631713555,0.578651685393258,0.905263157894737,-0.341845140032949,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-0.615,-0.332,"7:6","147/150","Q:H:F:E:Y:I:V:W",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR2707085","ERR2707085","lineage4.1.2","cd","Democratic Republic of Congo","pnca_p.his137pro","A","T","HIS","HA137","pnca_complex.pdb"
|
|
"H137P","L2","PZA","H","H137",137,"P",NA,"MDR","DM","hydrophobic","hydrophilic","basic","non-polar","pos","non-polar",3.419,-0.765,0.366,2.19045,-0.882,1.03,86,91,-0.415,7,7,84,0.375,"loop",-1.4,4.6,NA,NA,NA,NA,NA,34,3,0,0,3,0,0,0,0,2,0,2,0,0,0,0,0,0,4,-2,-4,2,0,-4,0,-0.193768996960486,0.311224489795918,0.0797809570291159,-0.150383631713555,0.578651685393258,0.905263157894737,-0.341845140032949,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-0.615,-0.332,"7:6","147/150","Q:H:F:E:Y:I:V:W",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage2","dr_mutations_pyrazinamide","PRO",0,"SAMN02584644","SRR1169035_SRR1166157","lineage2.2.1","md","Moldova","pnca_p.his137pro","A","T","HIS","HA137","pnca_complex.pdb"
|
|
"H137R","L2","PZA","H","H137",137,"R",1,"MDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",3.419,0.466,-0.272,0.488665,-0.317,0.21,76,85,-0.415,7,7,84,0.375,"loop",-1.4,4.6,0.0002874802357337,4.85191417753471,4.85191414039981,4.85118443551178,1.17497090855698,-52,-2,0,0,-2,0,0,0,0,0,0,0,0,0,0,0,0,1,0,4,-1,-2,0,-2,-4,0.208968609865471,-0.0702842377260982,0.0177982429941943,-0.0540494458653026,0.117977528089888,0.8,-0.341845140032949,"Stabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.615,-0.332,"7:6","147/150","Q:H:F:E:Y:I:V:W",1.57937329521209,0.114342297004304,1.0002536454007,1.57897279602454,0.581889091312819,40.4562911075324,0.685913110299906,0.137954936368295,0.860262754777729,0.351471331417763,67.0421060419706,0.278382201819561,"lineage2","dr_mutations_pyrazinamide","ARG",0,"MDR_10142","SRR6824295","lineage2.2.1","cn","China: Huqiu Hi-tech District, Suzhou City, Jiangsu Province","pnca_p.his137arg","A","T","HIS","HA137","pnca_complex.pdb"
|
|
"H137R","L4","PZA","H","H137",137,"R",NA,"MDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",3.419,0.466,-0.272,0.488665,-0.317,0.21,76,85,-0.415,7,7,84,0.375,"loop",-1.4,4.6,0.0002874802357337,4.85191417753471,4.85191414039981,4.85118443551178,1.17497090855698,-52,-2,0,0,-2,0,0,0,0,0,0,0,0,0,0,0,0,1,0,4,-1,-2,0,-2,-4,0.208968609865471,-0.0702842377260982,0.0177982429941943,-0.0540494458653026,0.117977528089888,0.8,-0.341845140032949,"Stabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.615,-0.332,"7:6","147/150","Q:H:F:E:Y:I:V:W",1.57937329521209,0.114342297004304,1.0002536454007,1.57897279602454,0.581889091312819,40.4562911075324,0.685913110299906,0.137954936368295,0.860262754777729,0.351471331417763,67.0421060419706,0.278382201819561,"lineage4","dr_mutations_pyrazinamide","ARG",0,"SAMN02381022","SRR1062912_SRR1049652_SRR1140664_SRR1049651","lineage4.6.1.2","ug","Uganda","pnca_p.his137arg","A","T","HIS","HA137","pnca_complex.pdb"
|
|
"H137R","L2","PZA","H","H137",137,"R",1,"XDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",3.419,0.466,-0.272,0.488665,-0.317,0.21,76,85,-0.415,7,7,84,0.375,"loop",-1.4,4.6,0.0002874802357337,4.85191417753471,4.85191414039981,4.85118443551178,1.17497090855698,-52,-2,0,0,-2,0,0,0,0,0,0,0,0,0,0,0,0,1,0,4,-1,-2,0,-2,-4,0.208968609865471,-0.0702842377260982,0.0177982429941943,-0.0540494458653026,0.117977528089888,0.8,-0.341845140032949,"Stabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.615,-0.332,"7:6","147/150","Q:H:F:E:Y:I:V:W",1.57937329521209,0.114342297004304,1.0002536454007,1.57897279602454,0.581889091312819,40.4562911075324,0.685913110299906,0.137954936368295,0.860262754777729,0.351471331417763,67.0421060419706,0.278382201819561,"lineage2","dr_mutations_pyrazinamide","ARG",0,"ERS457857","ERR552165_ERR552164","lineage2.2.1","uz","Nukus","pnca_p.his137arg","A","T","HIS","HA137","pnca_complex.pdb"
|
|
"H137R","L2","PZA","H","H137",137,"R",NA,"MDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",3.419,0.466,-0.272,0.488665,-0.317,0.21,76,85,-0.415,7,7,84,0.375,"loop",-1.4,4.6,0.0002874802357337,4.85191417753471,4.85191414039981,4.85118443551178,1.17497090855698,-52,-2,0,0,-2,0,0,0,0,0,0,0,0,0,0,0,0,1,0,4,-1,-2,0,-2,-4,0.208968609865471,-0.0702842377260982,0.0177982429941943,-0.0540494458653026,0.117977528089888,0.8,-0.341845140032949,"Stabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.615,-0.332,"7:6","147/150","Q:H:F:E:Y:I:V:W",1.57937329521209,0.114342297004304,1.0002536454007,1.57897279602454,0.581889091312819,40.4562911075324,0.685913110299906,0.137954936368295,0.860262754777729,0.351471331417763,67.0421060419706,0.278382201819561,"lineage2","dr_mutations_pyrazinamide","ARG",0,"SRS797100","SRR1723608_SRR1723607","lineage2.2.1","cn","China:Jiangsu","pnca_p.his137arg","A","T","HIS","HA137","pnca_complex.pdb"
|
|
"H137R","L2","PZA","H","H137",137,"R",0,"MDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",3.419,0.466,-0.272,0.488665,-0.317,0.21,76,85,-0.415,7,7,84,0.375,"loop",-1.4,4.6,0.0002874802357337,4.85191417753471,4.85191414039981,4.85118443551178,1.17497090855698,-52,-2,0,0,-2,0,0,0,0,0,0,0,0,0,0,0,0,1,0,4,-1,-2,0,-2,-4,0.208968609865471,-0.0702842377260982,0.0177982429941943,-0.0540494458653026,0.117977528089888,0.8,-0.341845140032949,"Stabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.615,-0.332,"7:6","147/150","Q:H:F:E:Y:I:V:W",1.57937329521209,0.114342297004304,1.0002536454007,1.57897279602454,0.581889091312819,40.4562911075324,0.685913110299906,0.137954936368295,0.860262754777729,0.351471331417763,67.0421060419706,0.278382201819561,"lineage2","dr_mutations_pyrazinamide","ARG",0,"ERS457427","ERR551558_ERR551557_ERR551556","lineage2.2.1","uz","Nukus","pnca_p.his137arg","A","T","HIS","HA137","pnca_complex.pdb"
|
|
"H137R","L2","PZA","H","H137",137,"R",0,"MDR","DM","hydrophobic","hydrophilic","basic","basic","pos","pos",3.419,0.466,-0.272,0.488665,-0.317,0.21,76,85,-0.415,7,7,84,0.375,"loop",-1.4,4.6,0.0002874802357337,4.85191417753471,4.85191414039981,4.85118443551178,1.17497090855698,-52,-2,0,0,-2,0,0,0,0,0,0,0,0,0,0,0,0,1,0,4,-1,-2,0,-2,-4,0.208968609865471,-0.0702842377260982,0.0177982429941943,-0.0540494458653026,0.117977528089888,0.8,-0.341845140032949,"Stabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.615,-0.332,"7:6","147/150","Q:H:F:E:Y:I:V:W",1.57937329521209,0.114342297004304,1.0002536454007,1.57897279602454,0.581889091312819,40.4562911075324,0.685913110299906,0.137954936368295,0.860262754777729,0.351471331417763,67.0421060419706,0.278382201819561,"lineage2","dr_mutations_pyrazinamide","ARG",0,"SAMEA2534815,ERS458217,ERR552677","ERR552677","lineage2.2.1","uz","Nukus","pnca_p.his137arg","A","T","HIS","HA137","pnca_complex.pdb"
|
|
"H137Y","L1","PZA","H","H137",137,"Y",NA,"Sensitive","OM","hydrophobic","hydrophobic","basic","neutral","pos","polar",3.419,-0.005,0.859,0.344473,-0.394,1.72,-7,53,-0.415,7,7,84,0.375,"loop",-1.4,4.6,7.18700589334483e-05,2.42412778478352,0.0001249735077034,0,1.03410070803344e-29,-42,3,0,0,3,0,0,0,0,2,0,2,0,0,0,0,0,-1,0,1,-4,-2,0,-2,0,-0.0012664640324214,0.730442176870748,0.0125464564864255,-0.0671781756180733,0.966292134831461,-0.0752688172043011,-0.341845140032949,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","neutral",-0.615,-0.332,"7:6","147/150","Q:H:F:E:Y:I:V:W",-8.98740878149642,0.940032862253633,119.468044435491,-0.0752285585987755,NA,4692673.51081285,0.384555509373631,1,0,0,188.544222231268,0.999999999999997,"lineage1","other_mutations_pyrazinamide","TYR",0,"ERR767966","ERR767966","lineage1.1.1","th","Thailand","pnca_p.his137tyr","A","T","HIS","HA137","pnca_complex.pdb"
|
|
"H137Y","L4","PZA","H","H137",137,"Y",0,"Sensitive","OM","hydrophobic","hydrophobic","basic","neutral","pos","polar",3.419,-0.005,0.859,0.344473,-0.394,1.72,-7,53,-0.415,7,7,84,0.375,"loop",-1.4,4.6,7.18700589334483e-05,2.42412778478352,0.0001249735077034,0,1.03410070803344e-29,-42,3,0,0,3,0,0,0,0,2,0,2,0,0,0,0,0,-1,0,1,-4,-2,0,-2,0,-0.0012664640324214,0.730442176870748,0.0125464564864255,-0.0671781756180733,0.966292134831461,-0.0752688172043011,-0.341845140032949,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","neutral",-0.615,-0.332,"7:6","147/150","Q:H:F:E:Y:I:V:W",-8.98740878149642,0.940032862253633,119.468044435491,-0.0752285585987755,NA,4692673.51081285,0.384555509373631,1,0,0,188.544222231268,0.999999999999997,"lineage4","other_mutations_pyrazinamide","TYR",0,"ERR2199858","ERR2199858","lineage4.1.2","de","Germany","pnca_p.his137tyr","A","T","HIS","HA137","pnca_complex.pdb"
|
|
"C138G","L4","PZA","C","C138",138,"G",NA,"Pre-XDR","OM","hydrophobic","hydrophobic","neutral","neutral","non-polar","non-polar",3.282,-0.012,-0.015,1.12063,-2.578,1.06,90,95,-1.148,9,9,12,0.0718562874251497,"helix",1.16666666666667,6.7,NA,NA,NA,NA,NA,16,0,0,0,0,0,0,0,0,2,0,0,0,0,0,0,0,3,0,3,0,6,0,9,19,-0.0030395136778115,-0.003875968992248,0.0408157839145099,-0.439556692242114,0.595505617977528,0.947368421052632,-0.945634266886326,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-1.221,-1.124,"9:9","147/150","C:S",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage4","other_mutations_pyrazinamide","GLY",0,"ERR1034711","ERR1034711","lineage4.1.2.1","pe","Peru","pnca_p.cys138gly","A","H","CYS","CA138","pnca_complex.pdb"
|
|
"C138G","L5","PZA","C","C138",138,"G",NA,"MDR","OM","hydrophobic","hydrophobic","neutral","neutral","non-polar","non-polar",3.282,-0.012,-0.015,1.12063,-2.578,1.06,90,95,-1.148,9,9,12,0.0718562874251497,"helix",1.16666666666667,6.7,NA,NA,NA,NA,NA,16,0,0,0,0,0,0,0,0,2,0,0,0,0,0,0,0,3,0,3,0,6,0,9,19,-0.0030395136778115,-0.003875968992248,0.0408157839145099,-0.439556692242114,0.595505617977528,0.947368421052632,-0.945634266886326,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-1.221,-1.124,"9:9","147/150","C:S",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage5","other_mutations_pyrazinamide","GLY",0,"ERR2707035","ERR2707035","lineage5","cd","Democratic Republic of Congo","pnca_p.cys138gly","A","H","CYS","CA138","pnca_complex.pdb"
|
|
"C138R","L2","PZA","C","C138",138,"R",1,"MDR","DM","hydrophobic","hydrophilic","neutral","basic","non-polar","pos",3.282,0.35,0.099,-2.11829,-2.383,0.53,91,95,-1.148,9,9,12,0.0718562874251497,"helix",1.16666666666667,6.7,0.0008624407072013,116.958174904943,3797407.11818115,Inf,52.5277145499225,-86,-32,0,0,-32,0,0,0,0,-2,0,-2,-2,0,0,0,0,-5,0,-1,-6,-14,0,-6,-12,0.15695067264574,0.0841836734693877,-0.407269476274706,-0.406308610400682,0.297752808988764,0.957894736842105,-0.945634266886326,"Stabilising","Stabilising","Stabilising","Destabilising","Stabilising","effect",-1.221,-1.124,"9:9","147/150","C:S",15.1498290544778,0.921917088417709,154.559892765108,0.0980191483278375,60.4370486597206,NA,2.06803058263964,6.09960824712391e-10,9.21469805705084,13.5248372165465,Inf,4.24219331644313e-13,"lineage2","dr_mutations_pyrazinamide","ARG",0,"ERR2041744","ERR2041744","lineage2.2.1","rs","Serbia","pnca_p.cys138arg","A","H","CYS","CA138","pnca_complex.pdb"
|
|
"C138R","L2","PZA","C","C138",138,"R",1,"Pre-XDR","DM","hydrophobic","hydrophilic","neutral","basic","non-polar","pos",3.282,0.35,0.099,-2.11829,-2.383,0.53,91,95,-1.148,9,9,12,0.0718562874251497,"helix",1.16666666666667,6.7,0.0008624407072013,116.958174904943,3797407.11818115,Inf,52.5277145499225,-86,-32,0,0,-32,0,0,0,0,-2,0,-2,-2,0,0,0,0,-5,0,-1,-6,-14,0,-6,-12,0.15695067264574,0.0841836734693877,-0.407269476274706,-0.406308610400682,0.297752808988764,0.957894736842105,-0.945634266886326,"Stabilising","Stabilising","Stabilising","Destabilising","Stabilising","effect",-1.221,-1.124,"9:9","147/150","C:S",15.1498290544778,0.921917088417709,154.559892765108,0.0980191483278375,60.4370486597206,NA,2.06803058263964,6.09960824712391e-10,9.21469805705084,13.5248372165465,Inf,4.24219331644313e-13,"lineage2","dr_mutations_pyrazinamide","ARG",0,"ERR2516898","ERR2516898","lineage2.2.1","gb","UK","pnca_p.cys138arg","A","H","CYS","CA138","pnca_complex.pdb"
|
|
"C138R","L2","PZA","C","C138",138,"R",1,"MDR","DM","hydrophobic","hydrophilic","neutral","basic","non-polar","pos",3.282,0.35,0.099,-2.11829,-2.383,0.53,91,95,-1.148,9,9,12,0.0718562874251497,"helix",1.16666666666667,6.7,0.0008624407072013,116.958174904943,3797407.11818115,Inf,52.5277145499225,-86,-32,0,0,-32,0,0,0,0,-2,0,-2,-2,0,0,0,0,-5,0,-1,-6,-14,0,-6,-12,0.15695067264574,0.0841836734693877,-0.407269476274706,-0.406308610400682,0.297752808988764,0.957894736842105,-0.945634266886326,"Stabilising","Stabilising","Stabilising","Destabilising","Stabilising","effect",-1.221,-1.124,"9:9","147/150","C:S",15.1498290544778,0.921917088417709,154.559892765108,0.0980191483278375,60.4370486597206,NA,2.06803058263964,6.09960824712391e-10,9.21469805705084,13.5248372165465,Inf,4.24219331644313e-13,"lineage2","dr_mutations_pyrazinamide","ARG",0,"ERR2041742","ERR2041742","lineage2.2.1","rs","Serbia","pnca_p.cys138arg","A","H","CYS","CA138","pnca_complex.pdb"
|
|
"C138R","L2","PZA","C","C138",138,"R",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","neutral","basic","non-polar","pos",3.282,0.35,0.099,-2.11829,-2.383,0.53,91,95,-1.148,9,9,12,0.0718562874251497,"helix",1.16666666666667,6.7,0.0008624407072013,116.958174904943,3797407.11818115,Inf,52.5277145499225,-86,-32,0,0,-32,0,0,0,0,-2,0,-2,-2,0,0,0,0,-5,0,-1,-6,-14,0,-6,-12,0.15695067264574,0.0841836734693877,-0.407269476274706,-0.406308610400682,0.297752808988764,0.957894736842105,-0.945634266886326,"Stabilising","Stabilising","Stabilising","Destabilising","Stabilising","effect",-1.221,-1.124,"9:9","147/150","C:S",15.1498290544778,0.921917088417709,154.559892765108,0.0980191483278375,60.4370486597206,NA,2.06803058263964,6.09960824712391e-10,9.21469805705084,13.5248372165465,Inf,4.24219331644313e-13,"lineage2","dr_mutations_pyrazinamide","ARG",0,"ERR144572,1853Q-sc-2012-02-21T11:37:43Z-1364809","ERR144572","lineage2.2.1","ru","Russia","pnca_p.cys138arg","A","H","CYS","CA138","pnca_complex.pdb"
|
|
"C138R","L3","PZA","C","C138",138,"R",1,"Other","DM","hydrophobic","hydrophilic","neutral","basic","non-polar","pos",3.282,0.35,0.099,-2.11829,-2.383,0.53,91,95,-1.148,9,9,12,0.0718562874251497,"helix",1.16666666666667,6.7,0.0008624407072013,116.958174904943,3797407.11818115,Inf,52.5277145499225,-86,-32,0,0,-32,0,0,0,0,-2,0,-2,-2,0,0,0,0,-5,0,-1,-6,-14,0,-6,-12,0.15695067264574,0.0841836734693877,-0.407269476274706,-0.406308610400682,0.297752808988764,0.957894736842105,-0.945634266886326,"Stabilising","Stabilising","Stabilising","Destabilising","Stabilising","effect",-1.221,-1.124,"9:9","147/150","C:S",15.1498290544778,0.921917088417709,154.559892765108,0.0980191483278375,60.4370486597206,NA,2.06803058263964,6.09960824712391e-10,9.21469805705084,13.5248372165465,Inf,4.24219331644313e-13,"lineage3","dr_mutations_pyrazinamide","ARG",0,"ERR2515160","ERR2515160","lineage3","za","South Africa","pnca_p.cys138arg","A","H","CYS","CA138","pnca_complex.pdb"
|
|
"C138R","L2","PZA","C","C138",138,"R",1,"Pre-XDR","DM","hydrophobic","hydrophilic","neutral","basic","non-polar","pos",3.282,0.35,0.099,-2.11829,-2.383,0.53,91,95,-1.148,9,9,12,0.0718562874251497,"helix",1.16666666666667,6.7,0.0008624407072013,116.958174904943,3797407.11818115,Inf,52.5277145499225,-86,-32,0,0,-32,0,0,0,0,-2,0,-2,-2,0,0,0,0,-5,0,-1,-6,-14,0,-6,-12,0.15695067264574,0.0841836734693877,-0.407269476274706,-0.406308610400682,0.297752808988764,0.957894736842105,-0.945634266886326,"Stabilising","Stabilising","Stabilising","Destabilising","Stabilising","effect",-1.221,-1.124,"9:9","147/150","C:S",15.1498290544778,0.921917088417709,154.559892765108,0.0980191483278375,60.4370486597206,NA,2.06803058263964,6.09960824712391e-10,9.21469805705084,13.5248372165465,Inf,4.24219331644313e-13,"lineage2","dr_mutations_pyrazinamide","ARG",0,"SAMEA2296953,ERS389340,ERR400382","ERR400382","lineage2.2.1","gb","United Kingdom","pnca_p.cys138arg","A","H","CYS","CA138","pnca_complex.pdb"
|
|
"C138R","L4","PZA","C","C138",138,"R",1,"Pre-XDR","DM","hydrophobic","hydrophilic","neutral","basic","non-polar","pos",3.282,0.35,0.099,-2.11829,-2.383,0.53,91,95,-1.148,9,9,12,0.0718562874251497,"helix",1.16666666666667,6.7,0.0008624407072013,116.958174904943,3797407.11818115,Inf,52.5277145499225,-86,-32,0,0,-32,0,0,0,0,-2,0,-2,-2,0,0,0,0,-5,0,-1,-6,-14,0,-6,-12,0.15695067264574,0.0841836734693877,-0.407269476274706,-0.406308610400682,0.297752808988764,0.957894736842105,-0.945634266886326,"Stabilising","Stabilising","Stabilising","Destabilising","Stabilising","effect",-1.221,-1.124,"9:9","147/150","C:S",15.1498290544778,0.921917088417709,154.559892765108,0.0980191483278375,60.4370486597206,NA,2.06803058263964,6.09960824712391e-10,9.21469805705084,13.5248372165465,Inf,4.24219331644313e-13,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERR133903,0671F-sc-2012-02-09T18:56:42Z-1355236","ERR133903","lineage4.3.3","ru","Russia,Samara","pnca_p.cys138arg","A","H","CYS","CA138","pnca_complex.pdb"
|
|
"C138R","L4","PZA","C","C138",138,"R",1,"MDR","DM","hydrophobic","hydrophilic","neutral","basic","non-polar","pos",3.282,0.35,0.099,-2.11829,-2.383,0.53,91,95,-1.148,9,9,12,0.0718562874251497,"helix",1.16666666666667,6.7,0.0008624407072013,116.958174904943,3797407.11818115,Inf,52.5277145499225,-86,-32,0,0,-32,0,0,0,0,-2,0,-2,-2,0,0,0,0,-5,0,-1,-6,-14,0,-6,-12,0.15695067264574,0.0841836734693877,-0.407269476274706,-0.406308610400682,0.297752808988764,0.957894736842105,-0.945634266886326,"Stabilising","Stabilising","Stabilising","Destabilising","Stabilising","effect",-1.221,-1.124,"9:9","147/150","C:S",15.1498290544778,0.921917088417709,154.559892765108,0.0980191483278375,60.4370486597206,NA,2.06803058263964,6.09960824712391e-10,9.21469805705084,13.5248372165465,Inf,4.24219331644313e-13,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERR2516407","ERR2516407","lineage4.3.3","nl","Netherlands","pnca_p.cys138arg","A","H","CYS","CA138","pnca_complex.pdb"
|
|
"C138R","L4","PZA","C","C138",138,"R",NA,"XDR","DM","hydrophobic","hydrophilic","neutral","basic","non-polar","pos",3.282,0.35,0.099,-2.11829,-2.383,0.53,91,95,-1.148,9,9,12,0.0718562874251497,"helix",1.16666666666667,6.7,0.0008624407072013,116.958174904943,3797407.11818115,Inf,52.5277145499225,-86,-32,0,0,-32,0,0,0,0,-2,0,-2,-2,0,0,0,0,-5,0,-1,-6,-14,0,-6,-12,0.15695067264574,0.0841836734693877,-0.407269476274706,-0.406308610400682,0.297752808988764,0.957894736842105,-0.945634266886326,"Stabilising","Stabilising","Stabilising","Destabilising","Stabilising","effect",-1.221,-1.124,"9:9","147/150","C:S",15.1498290544778,0.921917088417709,154.559892765108,0.0980191483278375,60.4370486597206,NA,2.06803058263964,6.09960824712391e-10,9.21469805705084,13.5248372165465,Inf,4.24219331644313e-13,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERR1193862","ERR1193862","lineage4.3.3","us","Georgia","pnca_p.cys138arg","A","H","CYS","CA138","pnca_complex.pdb"
|
|
"C138R","L2","PZA","C","C138",138,"R",1,"Pre-XDR","DM","hydrophobic","hydrophilic","neutral","basic","non-polar","pos",3.282,0.35,0.099,-2.11829,-2.383,0.53,91,95,-1.148,9,9,12,0.0718562874251497,"helix",1.16666666666667,6.7,0.0008624407072013,116.958174904943,3797407.11818115,Inf,52.5277145499225,-86,-32,0,0,-32,0,0,0,0,-2,0,-2,-2,0,0,0,0,-5,0,-1,-6,-14,0,-6,-12,0.15695067264574,0.0841836734693877,-0.407269476274706,-0.406308610400682,0.297752808988764,0.957894736842105,-0.945634266886326,"Stabilising","Stabilising","Stabilising","Destabilising","Stabilising","effect",-1.221,-1.124,"9:9","147/150","C:S",15.1498290544778,0.921917088417709,154.559892765108,0.0980191483278375,60.4370486597206,NA,2.06803058263964,6.09960824712391e-10,9.21469805705084,13.5248372165465,Inf,4.24219331644313e-13,"lineage2","dr_mutations_pyrazinamide","ARG",0,"0802Y-sc-2012-02-09T18:57:12Z-1355278,ERR133945","ERR133945","lineage2.2.1","ru","Russia","pnca_p.cys138arg","A","H","CYS","CA138","pnca_complex.pdb"
|
|
"C138R","L2","PZA","C","C138",138,"R",1,"Pre-XDR","DM","hydrophobic","hydrophilic","neutral","basic","non-polar","pos",3.282,0.35,0.099,-2.11829,-2.383,0.53,91,95,-1.148,9,9,12,0.0718562874251497,"helix",1.16666666666667,6.7,0.0008624407072013,116.958174904943,3797407.11818115,Inf,52.5277145499225,-86,-32,0,0,-32,0,0,0,0,-2,0,-2,-2,0,0,0,0,-5,0,-1,-6,-14,0,-6,-12,0.15695067264574,0.0841836734693877,-0.407269476274706,-0.406308610400682,0.297752808988764,0.957894736842105,-0.945634266886326,"Stabilising","Stabilising","Stabilising","Destabilising","Stabilising","effect",-1.221,-1.124,"9:9","147/150","C:S",15.1498290544778,0.921917088417709,154.559892765108,0.0980191483278375,60.4370486597206,NA,2.06803058263964,6.09960824712391e-10,9.21469805705084,13.5248372165465,Inf,4.24219331644313e-13,"lineage2","dr_mutations_pyrazinamide","ARG",0,"ERS458430,SAMEA2535028","ERR552955_ERR552956","lineage2.2.1","uz","Nukus","pnca_p.cys138arg","A","H","CYS","CA138","pnca_complex.pdb"
|
|
"C138R","L4","PZA","C","C138",138,"R",1,"Pre-XDR","DM","hydrophobic","hydrophilic","neutral","basic","non-polar","pos",3.282,0.35,0.099,-2.11829,-2.383,0.53,91,95,-1.148,9,9,12,0.0718562874251497,"helix",1.16666666666667,6.7,0.0008624407072013,116.958174904943,3797407.11818115,Inf,52.5277145499225,-86,-32,0,0,-32,0,0,0,0,-2,0,-2,-2,0,0,0,0,-5,0,-1,-6,-14,0,-6,-12,0.15695067264574,0.0841836734693877,-0.407269476274706,-0.406308610400682,0.297752808988764,0.957894736842105,-0.945634266886326,"Stabilising","Stabilising","Stabilising","Destabilising","Stabilising","effect",-1.221,-1.124,"9:9","147/150","C:S",15.1498290544778,0.921917088417709,154.559892765108,0.0980191483278375,60.4370486597206,NA,2.06803058263964,6.09960824712391e-10,9.21469805705084,13.5248372165465,Inf,4.24219331644313e-13,"lineage4","dr_mutations_pyrazinamide","ARG",0,"1766W-sc-2012-02-21T11:37:19Z-1364776,ERR137284","ERR137284","lineage4.3.3","ru","Russia,Samara","pnca_p.cys138arg","A","H","CYS","CA138","pnca_complex.pdb"
|
|
"C138R","L2","PZA","C","C138",138,"R",1,"Pre-XDR","DM","hydrophobic","hydrophilic","neutral","basic","non-polar","pos",3.282,0.35,0.099,-2.11829,-2.383,0.53,91,95,-1.148,9,9,12,0.0718562874251497,"helix",1.16666666666667,6.7,0.0008624407072013,116.958174904943,3797407.11818115,Inf,52.5277145499225,-86,-32,0,0,-32,0,0,0,0,-2,0,-2,-2,0,0,0,0,-5,0,-1,-6,-14,0,-6,-12,0.15695067264574,0.0841836734693877,-0.407269476274706,-0.406308610400682,0.297752808988764,0.957894736842105,-0.945634266886326,"Stabilising","Stabilising","Stabilising","Destabilising","Stabilising","effect",-1.221,-1.124,"9:9","147/150","C:S",15.1498290544778,0.921917088417709,154.559892765108,0.0980191483278375,60.4370486597206,NA,2.06803058263964,6.09960824712391e-10,9.21469805705084,13.5248372165465,Inf,4.24219331644313e-13,"lineage2","dr_mutations_pyrazinamide","ARG",0,"ETB0080","SRR6257027","lineage2.2.1","ru","Russia:Bryansk Region","pnca_p.cys138arg","A","H","CYS","CA138","pnca_complex.pdb"
|
|
"C138R","L2","PZA","C","C138",138,"R",1,"MDR","DM","hydrophobic","hydrophilic","neutral","basic","non-polar","pos",3.282,0.35,0.099,-2.11829,-2.383,0.53,91,95,-1.148,9,9,12,0.0718562874251497,"helix",1.16666666666667,6.7,0.0008624407072013,116.958174904943,3797407.11818115,Inf,52.5277145499225,-86,-32,0,0,-32,0,0,0,0,-2,0,-2,-2,0,0,0,0,-5,0,-1,-6,-14,0,-6,-12,0.15695067264574,0.0841836734693877,-0.407269476274706,-0.406308610400682,0.297752808988764,0.957894736842105,-0.945634266886326,"Stabilising","Stabilising","Stabilising","Destabilising","Stabilising","effect",-1.221,-1.124,"9:9","147/150","C:S",15.1498290544778,0.921917088417709,154.559892765108,0.0980191483278375,60.4370486597206,NA,2.06803058263964,6.09960824712391e-10,9.21469805705084,13.5248372165465,Inf,4.24219331644313e-13,"lineage2","dr_mutations_pyrazinamide","ARG",0,"ERS457813","ERR552099_ERR552098","lineage2.2.1","uz","Nukus","pnca_p.cys138arg","A","H","CYS","CA138","pnca_complex.pdb"
|
|
"C138S","L2","PZA","C","C138",138,"S",NA,"MDR","DM","hydrophobic","hydrophilic","neutral","neutral","non-polar","polar",3.282,0.814,-0.002,-0.229289,-1.639,1.02,87,91,-1.148,9,9,12,0.0718562874251497,"helix",1.16666666666667,6.7,NA,NA,NA,NA,NA,4,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,3,0,3,0,2,0,0,2,0.365022421524664,-0.000516795865633,-0.0440838652618626,-0.279454390451833,0.573033707865168,0.91578947368421,-0.945634266886326,"Stabilising","Destabilising","Stabilising","Destabilising","Stabilising","effect",-1.221,-1.124,"9:9","147/150","C:S",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage2","dr_mutations_pyrazinamide","SER",0,"SRR7517719","SRR7517719","lineage2.2.1","ch","Switzerland","pnca_p.cys138ser","A","H","CYS","CA138","pnca_complex.pdb"
|
|
"C138W","L2","PZA","C","C138",138,"W",NA,"Pre-MDR","OM","hydrophobic","hydrophobic","neutral","non-polar","non-polar","non-polar",3.282,0.943,-1.048,-1.71951,-1.165,-0.99,91,95,-1.148,9,9,12,0.0718562874251497,"helix",1.16666666666667,6.7,NA,NA,NA,NA,NA,-72,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,-2,0,0,-3,-12,0,-2,-16,0.422869955156951,-0.270801033591731,-0.330598707990464,-0.198635976129582,-0.259162303664921,0.957894736842105,-0.945634266886326,"Stabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.221,-1.124,"9:9","147/150","C:S",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage2","other_mutations_pyrazinamide","TRP",0,"SRS797297","SRR1723826_SRR1723827","lineage2.2.1","cn","China:Fujian","pnca_p.cys138trp","A","H","CYS","CA138","pnca_complex.pdb"
|
|
"C138Y","L7","PZA","C","C138",138,"Y",NA,"Other","DM","hydrophobic","hydrophobic","neutral","neutral","non-polar","polar",3.282,0.914,-0.518,-0.565013,-1.271,-0.44,90,95,-1.148,9,9,12,0.0718562874251497,"helix",1.16666666666667,6.7,NA,NA,NA,NA,NA,-72,-40,0,0,-40,0,0,0,0,0,0,-2,0,0,0,0,0,1,0,0,1,-12,0,-2,-14,0.409865470852018,-0.133850129198966,-0.108631277397524,-0.216709292412617,-0.115183246073298,0.947368421052632,-0.945634266886326,"Stabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.221,-1.124,"9:9","147/150","C:S",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage7","dr_mutations_pyrazinamide","TYR",0,"ERR233349","ERR233349","lineage7","","","pnca_p.cys138tyr","A","H","CYS","CA138","pnca_complex.pdb"
|
|
"C138Y","L4","PZA","C","C138",138,"Y",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","neutral","neutral","non-polar","polar",3.282,0.914,-0.518,-0.565013,-1.271,-0.44,90,95,-1.148,9,9,12,0.0718562874251497,"helix",1.16666666666667,6.7,NA,NA,NA,NA,NA,-72,-40,0,0,-40,0,0,0,0,0,0,-2,0,0,0,0,0,1,0,0,1,-12,0,-2,-14,0.409865470852018,-0.133850129198966,-0.108631277397524,-0.216709292412617,-0.115183246073298,0.947368421052632,-0.945634266886326,"Stabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.221,-1.124,"9:9","147/150","C:S",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage4","dr_mutations_pyrazinamide","TYR",0,"SRS935949,SAMN03653220","SRR2024914","lineage4.2.2","cn","China","pnca_p.cys138tyr","A","H","CYS","CA138","pnca_complex.pdb"
|
|
"C138Y","L7","PZA","C","C138",138,"Y",NA,"Other","DM","hydrophobic","hydrophobic","neutral","neutral","non-polar","polar",3.282,0.914,-0.518,-0.565013,-1.271,-0.44,90,95,-1.148,9,9,12,0.0718562874251497,"helix",1.16666666666667,6.7,NA,NA,NA,NA,NA,-72,-40,0,0,-40,0,0,0,0,0,0,-2,0,0,0,0,0,1,0,0,1,-12,0,-2,-14,0.409865470852018,-0.133850129198966,-0.108631277397524,-0.216709292412617,-0.115183246073298,0.947368421052632,-0.945634266886326,"Stabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.221,-1.124,"9:9","147/150","C:S",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage7","dr_mutations_pyrazinamide","TYR",0,"ERR1200636","ERR1200636","lineage7","et","Ethiopia","pnca_p.cys138tyr","A","H","CYS","CA138","pnca_complex.pdb"
|
|
"C138Y","L4","PZA","C","C138",138,"Y",NA,"MDR","DM","hydrophobic","hydrophobic","neutral","neutral","non-polar","polar",3.282,0.914,-0.518,-0.565013,-1.271,-0.44,90,95,-1.148,9,9,12,0.0718562874251497,"helix",1.16666666666667,6.7,NA,NA,NA,NA,NA,-72,-40,0,0,-40,0,0,0,0,0,0,-2,0,0,0,0,0,1,0,0,1,-12,0,-2,-14,0.409865470852018,-0.133850129198966,-0.108631277397524,-0.216709292412617,-0.115183246073298,0.947368421052632,-0.945634266886326,"Stabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.221,-1.124,"9:9","147/150","C:S",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage4","dr_mutations_pyrazinamide","TYR",0,"SRS935993,SAMN03653241","SRR2024937","lineage4.2.2","cn","China","pnca_p.cys138tyr","A","H","CYS","CA138","pnca_complex.pdb"
|
|
"C138Y","L7","PZA","C","C138",138,"Y",NA,"Other","DM","hydrophobic","hydrophobic","neutral","neutral","non-polar","polar",3.282,0.914,-0.518,-0.565013,-1.271,-0.44,90,95,-1.148,9,9,12,0.0718562874251497,"helix",1.16666666666667,6.7,NA,NA,NA,NA,NA,-72,-40,0,0,-40,0,0,0,0,0,0,-2,0,0,0,0,0,1,0,0,1,-12,0,-2,-14,0.409865470852018,-0.133850129198966,-0.108631277397524,-0.216709292412617,-0.115183246073298,0.947368421052632,-0.945634266886326,"Stabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.221,-1.124,"9:9","147/150","C:S",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage7","dr_mutations_pyrazinamide","TYR",0,"ERR1200617","ERR1200617","lineage7","et","Ethiopia","pnca_p.cys138tyr","A","H","CYS","CA138","pnca_complex.pdb"
|
|
"V139A","L4","PZA","V","V139",139,"A",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",5.113,-0.537,-1.598,2.24246,-2.438,-1.84,52,75,-1.171,9,9,0,0,"helix",0.733333333333333,9.18,0.0018686215322696,4.8698224852071,4.86982245520442,4.86909461472896,17.6365403604529,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,2,0,4,7,-0.136018237082067,-0.412919896640827,0.0816752744411017,-0.415686274509804,-0.481675392670157,0.547368421052632,-0.964579901153213,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","147/150","I:V:A",1.58305747959306,5.59300498642966e-05,0.392881092301541,4.02935521869819,2.23340951898872,10.6183850984524,0.687513130598596,0.0001170700255588,3.93155428682984,2.07661167855124,11.4195822840533,2.67400952353788e-05,"lineage4","dr_mutations_pyrazinamide","ALA",0,"ERR751572","ERR751572","lineage4.3.4.2","pe","","pnca_p.val139ala","A","H","VAL","VA139","pnca_complex.pdb"
|
|
"V139A","L4","PZA","V","V139",139,"A",1,"MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",5.113,-0.537,-1.598,2.24246,-2.438,-1.84,52,75,-1.171,9,9,0,0,"helix",0.733333333333333,9.18,0.0018686215322696,4.8698224852071,4.86982245520442,4.86909461472896,17.6365403604529,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,2,0,4,7,-0.136018237082067,-0.412919896640827,0.0816752744411017,-0.415686274509804,-0.481675392670157,0.547368421052632,-0.964579901153213,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","147/150","I:V:A",1.58305747959306,5.59300498642966e-05,0.392881092301541,4.02935521869819,2.23340951898872,10.6183850984524,0.687513130598596,0.0001170700255588,3.93155428682984,2.07661167855124,11.4195822840533,2.67400952353788e-05,"lineage4","dr_mutations_pyrazinamide","ALA",0,"ERR1034788","ERR1034788","lineage4.1.2.1","pe","Peru","pnca_p.val139ala","A","H","VAL","VA139","pnca_complex.pdb"
|
|
"V139A","L4","PZA","V","V139",139,"A",0,"MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",5.113,-0.537,-1.598,2.24246,-2.438,-1.84,52,75,-1.171,9,9,0,0,"helix",0.733333333333333,9.18,0.0018686215322696,4.8698224852071,4.86982245520442,4.86909461472896,17.6365403604529,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,2,0,4,7,-0.136018237082067,-0.412919896640827,0.0816752744411017,-0.415686274509804,-0.481675392670157,0.547368421052632,-0.964579901153213,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","147/150","I:V:A",1.58305747959306,5.59300498642966e-05,0.392881092301541,4.02935521869819,2.23340951898872,10.6183850984524,0.687513130598596,0.0001170700255588,3.93155428682984,2.07661167855124,11.4195822840533,2.67400952353788e-05,"lineage4","dr_mutations_pyrazinamide","ALA",0,"SAMN03647122","SRR2099949","lineage4.1.1.3","","","pnca_p.val139ala","A","H","VAL","VA139","pnca_complex.pdb"
|
|
"V139A","L2","PZA","V","V139",139,"A",1,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",5.113,-0.537,-1.598,2.24246,-2.438,-1.84,52,75,-1.171,9,9,0,0,"helix",0.733333333333333,9.18,0.0018686215322696,4.8698224852071,4.86982245520442,4.86909461472896,17.6365403604529,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,2,0,4,7,-0.136018237082067,-0.412919896640827,0.0816752744411017,-0.415686274509804,-0.481675392670157,0.547368421052632,-0.964579901153213,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","147/150","I:V:A",1.58305747959306,5.59300498642966e-05,0.392881092301541,4.02935521869819,2.23340951898872,10.6183850984524,0.687513130598596,0.0001170700255588,3.93155428682984,2.07661167855124,11.4195822840533,2.67400952353788e-05,"lineage2","dr_mutations_pyrazinamide","ALA",0,"SAMN10961309","SRR8651562","lineage2.2.1","cn","China:Wenzhou","pnca_p.val139ala","A","H","VAL","VA139","pnca_complex.pdb"
|
|
"V139A","L2","PZA","V","V139",139,"A",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",5.113,-0.537,-1.598,2.24246,-2.438,-1.84,52,75,-1.171,9,9,0,0,"helix",0.733333333333333,9.18,0.0018686215322696,4.8698224852071,4.86982245520442,4.86909461472896,17.6365403604529,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,2,0,4,7,-0.136018237082067,-0.412919896640827,0.0816752744411017,-0.415686274509804,-0.481675392670157,0.547368421052632,-0.964579901153213,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","147/150","I:V:A",1.58305747959306,5.59300498642966e-05,0.392881092301541,4.02935521869819,2.23340951898872,10.6183850984524,0.687513130598596,0.0001170700255588,3.93155428682984,2.07661167855124,11.4195822840533,2.67400952353788e-05,"lineage2","dr_mutations_pyrazinamide","ALA",0,"ERR502892","ERR502892","lineage2.2.1","","","pnca_p.val139ala","A","H","VAL","VA139","pnca_complex.pdb"
|
|
"V139A","L3","PZA","V","V139",139,"A",0,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",5.113,-0.537,-1.598,2.24246,-2.438,-1.84,52,75,-1.171,9,9,0,0,"helix",0.733333333333333,9.18,0.0018686215322696,4.8698224852071,4.86982245520442,4.86909461472896,17.6365403604529,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,2,0,4,7,-0.136018237082067,-0.412919896640827,0.0816752744411017,-0.415686274509804,-0.481675392670157,0.547368421052632,-0.964579901153213,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","147/150","I:V:A",1.58305747959306,5.59300498642966e-05,0.392881092301541,4.02935521869819,2.23340951898872,10.6183850984524,0.687513130598596,0.0001170700255588,3.93155428682984,2.07661167855124,11.4195822840533,2.67400952353788e-05,"lineage3","dr_mutations_pyrazinamide","ALA",0,"ERR3335761","ERR3335761","lineage3","pk","Pakistan","pnca_p.val139ala","A","H","VAL","VA139","pnca_complex.pdb"
|
|
"V139A","L1","PZA","V","V139",139,"A",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",5.113,-0.537,-1.598,2.24246,-2.438,-1.84,52,75,-1.171,9,9,0,0,"helix",0.733333333333333,9.18,0.0018686215322696,4.8698224852071,4.86982245520442,4.86909461472896,17.6365403604529,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,2,0,4,7,-0.136018237082067,-0.412919896640827,0.0816752744411017,-0.415686274509804,-0.481675392670157,0.547368421052632,-0.964579901153213,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","147/150","I:V:A",1.58305747959306,5.59300498642966e-05,0.392881092301541,4.02935521869819,2.23340951898872,10.6183850984524,0.687513130598596,0.0001170700255588,3.93155428682984,2.07661167855124,11.4195822840533,2.67400952353788e-05,"lineage1","dr_mutations_pyrazinamide","ALA",0,"ERR3256270","ERR3256270","lineage1.2.1","ph","Philippines","pnca_p.val139ala","A","H","VAL","VA139","pnca_complex.pdb"
|
|
"V139A","L2","PZA","V","V139",139,"A",1,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",5.113,-0.537,-1.598,2.24246,-2.438,-1.84,52,75,-1.171,9,9,0,0,"helix",0.733333333333333,9.18,0.0018686215322696,4.8698224852071,4.86982245520442,4.86909461472896,17.6365403604529,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,2,0,4,7,-0.136018237082067,-0.412919896640827,0.0816752744411017,-0.415686274509804,-0.481675392670157,0.547368421052632,-0.964579901153213,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","147/150","I:V:A",1.58305747959306,5.59300498642966e-05,0.392881092301541,4.02935521869819,2.23340951898872,10.6183850984524,0.687513130598596,0.0001170700255588,3.93155428682984,2.07661167855124,11.4195822840533,2.67400952353788e-05,"lineage2","dr_mutations_pyrazinamide","ALA",0,"2339T-sc-2012-10-11T13:39:11Z-1494250,ERR229931","ERR229931","lineage2.2.1","ru","Russia,Samara","pnca_p.val139ala","A","H","VAL","VA139","pnca_complex.pdb"
|
|
"V139A","L2","PZA","V","V139",139,"A",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",5.113,-0.537,-1.598,2.24246,-2.438,-1.84,52,75,-1.171,9,9,0,0,"helix",0.733333333333333,9.18,0.0018686215322696,4.8698224852071,4.86982245520442,4.86909461472896,17.6365403604529,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,2,0,4,7,-0.136018237082067,-0.412919896640827,0.0816752744411017,-0.415686274509804,-0.481675392670157,0.547368421052632,-0.964579901153213,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","147/150","I:V:A",1.58305747959306,5.59300498642966e-05,0.392881092301541,4.02935521869819,2.23340951898872,10.6183850984524,0.687513130598596,0.0001170700255588,3.93155428682984,2.07661167855124,11.4195822840533,2.67400952353788e-05,"lineage2","dr_mutations_pyrazinamide","ALA",0,"ERR067621,0057N-sc-2011-09-07T13:19:15Z-1276468","ERR067621","lineage2.2.1","ru","Russia","pnca_p.val139ala","A","H","VAL","VA139","pnca_complex.pdb"
|
|
"V139A","L2","PZA","V","V139",139,"A",NA,"XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",5.113,-0.537,-1.598,2.24246,-2.438,-1.84,52,75,-1.171,9,9,0,0,"helix",0.733333333333333,9.18,0.0018686215322696,4.8698224852071,4.86982245520442,4.86909461472896,17.6365403604529,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,2,0,4,7,-0.136018237082067,-0.412919896640827,0.0816752744411017,-0.415686274509804,-0.481675392670157,0.547368421052632,-0.964579901153213,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","147/150","I:V:A",1.58305747959306,5.59300498642966e-05,0.392881092301541,4.02935521869819,2.23340951898872,10.6183850984524,0.687513130598596,0.0001170700255588,3.93155428682984,2.07661167855124,11.4195822840533,2.67400952353788e-05,"lineage2","dr_mutations_pyrazinamide","ALA",0,"ERR017784","ERR017784","lineage2.2.1","","UK","pnca_p.val139ala","A","H","VAL","VA139","pnca_complex.pdb"
|
|
"V139A","L4","PZA","V","V139",139,"A",0,"Pre-MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",5.113,-0.537,-1.598,2.24246,-2.438,-1.84,52,75,-1.171,9,9,0,0,"helix",0.733333333333333,9.18,0.0018686215322696,4.8698224852071,4.86982245520442,4.86909461472896,17.6365403604529,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,2,0,4,7,-0.136018237082067,-0.412919896640827,0.0816752744411017,-0.415686274509804,-0.481675392670157,0.547368421052632,-0.964579901153213,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","147/150","I:V:A",1.58305747959306,5.59300498642966e-05,0.392881092301541,4.02935521869819,2.23340951898872,10.6183850984524,0.687513130598596,0.0001170700255588,3.93155428682984,2.07661167855124,11.4195822840533,2.67400952353788e-05,"lineage4","dr_mutations_pyrazinamide","ALA",0,"SAMN10961349","SRR8651585","lineage4.4.2","cn","China:Wenzhou","pnca_p.val139ala","A","H","VAL","VA139","pnca_complex.pdb"
|
|
"V139A","L1","PZA","V","V139",139,"A",1,"MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",5.113,-0.537,-1.598,2.24246,-2.438,-1.84,52,75,-1.171,9,9,0,0,"helix",0.733333333333333,9.18,0.0018686215322696,4.8698224852071,4.86982245520442,4.86909461472896,17.6365403604529,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,2,0,4,7,-0.136018237082067,-0.412919896640827,0.0816752744411017,-0.415686274509804,-0.481675392670157,0.547368421052632,-0.964579901153213,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","147/150","I:V:A",1.58305747959306,5.59300498642966e-05,0.392881092301541,4.02935521869819,2.23340951898872,10.6183850984524,0.687513130598596,0.0001170700255588,3.93155428682984,2.07661167855124,11.4195822840533,2.67400952353788e-05,"lineage1","dr_mutations_pyrazinamide","ALA",0,"ERR2510316","ERR2510316","lineage1.1.2","pk","Pakistan","pnca_p.val139ala","A","H","VAL","VA139","pnca_complex.pdb"
|
|
"V139A","L2","PZA","V","V139",139,"A",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",5.113,-0.537,-1.598,2.24246,-2.438,-1.84,52,75,-1.171,9,9,0,0,"helix",0.733333333333333,9.18,0.0018686215322696,4.8698224852071,4.86982245520442,4.86909461472896,17.6365403604529,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,2,0,4,7,-0.136018237082067,-0.412919896640827,0.0816752744411017,-0.415686274509804,-0.481675392670157,0.547368421052632,-0.964579901153213,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","147/150","I:V:A",1.58305747959306,5.59300498642966e-05,0.392881092301541,4.02935521869819,2.23340951898872,10.6183850984524,0.687513130598596,0.0001170700255588,3.93155428682984,2.07661167855124,11.4195822840533,2.67400952353788e-05,"lineage2","dr_mutations_pyrazinamide","ALA",0,"ERR2513770","ERR2513770","lineage2.2.1.1","gb","UK","pnca_p.val139ala","A","H","VAL","VA139","pnca_complex.pdb"
|
|
"V139A","L3","PZA","V","V139",139,"A",0,"Pre-MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",5.113,-0.537,-1.598,2.24246,-2.438,-1.84,52,75,-1.171,9,9,0,0,"helix",0.733333333333333,9.18,0.0018686215322696,4.8698224852071,4.86982245520442,4.86909461472896,17.6365403604529,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,2,0,4,7,-0.136018237082067,-0.412919896640827,0.0816752744411017,-0.415686274509804,-0.481675392670157,0.547368421052632,-0.964579901153213,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","147/150","I:V:A",1.58305747959306,5.59300498642966e-05,0.392881092301541,4.02935521869819,2.23340951898872,10.6183850984524,0.687513130598596,0.0001170700255588,3.93155428682984,2.07661167855124,11.4195822840533,2.67400952353788e-05,"lineage3","dr_mutations_pyrazinamide","ALA",0,"ERR038743","ERR038743","lineage3","ug","Uganda","pnca_p.val139ala","A","H","VAL","VA139","pnca_complex.pdb"
|
|
"V139A","L2","PZA","V","V139",139,"A",NA,"XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",5.113,-0.537,-1.598,2.24246,-2.438,-1.84,52,75,-1.171,9,9,0,0,"helix",0.733333333333333,9.18,0.0018686215322696,4.8698224852071,4.86982245520442,4.86909461472896,17.6365403604529,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,2,0,4,7,-0.136018237082067,-0.412919896640827,0.0816752744411017,-0.415686274509804,-0.481675392670157,0.547368421052632,-0.964579901153213,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","147/150","I:V:A",1.58305747959306,5.59300498642966e-05,0.392881092301541,4.02935521869819,2.23340951898872,10.6183850984524,0.687513130598596,0.0001170700255588,3.93155428682984,2.07661167855124,11.4195822840533,2.67400952353788e-05,"lineage2","dr_mutations_pyrazinamide","ALA",0,"SAMN02419583","SRR1181132_SRR1162531_SRR1158907_SRR1181329","lineage2.2.1","by","Belarus","pnca_p.val139ala","A","H","VAL","VA139","pnca_complex.pdb"
|
|
"V139A","L2","PZA","V","V139",139,"A",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",5.113,-0.537,-1.598,2.24246,-2.438,-1.84,52,75,-1.171,9,9,0,0,"helix",0.733333333333333,9.18,0.0018686215322696,4.8698224852071,4.86982245520442,4.86909461472896,17.6365403604529,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,2,0,4,7,-0.136018237082067,-0.412919896640827,0.0816752744411017,-0.415686274509804,-0.481675392670157,0.547368421052632,-0.964579901153213,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","147/150","I:V:A",1.58305747959306,5.59300498642966e-05,0.392881092301541,4.02935521869819,2.23340951898872,10.6183850984524,0.687513130598596,0.0001170700255588,3.93155428682984,2.07661167855124,11.4195822840533,2.67400952353788e-05,"lineage2","dr_mutations_pyrazinamide","ALA",0,"SRS797022","SRR1723520","lineage2.2.1","cn","China:Jiangxi","pnca_p.val139ala","A","H","VAL","VA139","pnca_complex.pdb"
|
|
"V139A","L2","PZA","V","V139",139,"A",0,"XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",5.113,-0.537,-1.598,2.24246,-2.438,-1.84,52,75,-1.171,9,9,0,0,"helix",0.733333333333333,9.18,0.0018686215322696,4.8698224852071,4.86982245520442,4.86909461472896,17.6365403604529,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,2,0,4,7,-0.136018237082067,-0.412919896640827,0.0816752744411017,-0.415686274509804,-0.481675392670157,0.547368421052632,-0.964579901153213,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","147/150","I:V:A",1.58305747959306,5.59300498642966e-05,0.392881092301541,4.02935521869819,2.23340951898872,10.6183850984524,0.687513130598596,0.0001170700255588,3.93155428682984,2.07661167855124,11.4195822840533,2.67400952353788e-05,"lineage2","dr_mutations_pyrazinamide","ALA",0,"ERR229984,2487E-sc-2012-10-11T13:40:03Z-1494303","ERR229984","lineage2.2.1","ru","Russia,Samara","pnca_p.val139ala","A","H","VAL","VA139","pnca_complex.pdb"
|
|
"V139A","L4","PZA","V","V139",139,"A",1,"XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",5.113,-0.537,-1.598,2.24246,-2.438,-1.84,52,75,-1.171,9,9,0,0,"helix",0.733333333333333,9.18,0.0018686215322696,4.8698224852071,4.86982245520442,4.86909461472896,17.6365403604529,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,2,0,4,7,-0.136018237082067,-0.412919896640827,0.0816752744411017,-0.415686274509804,-0.481675392670157,0.547368421052632,-0.964579901153213,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","147/150","I:V:A",1.58305747959306,5.59300498642966e-05,0.392881092301541,4.02935521869819,2.23340951898872,10.6183850984524,0.687513130598596,0.0001170700255588,3.93155428682984,2.07661167855124,11.4195822840533,2.67400952353788e-05,"lineage4","dr_mutations_pyrazinamide","ALA",0,"ERR2510882","ERR2510882","lineage4.2.1","it","Italy","pnca_p.val139ala","A","H","VAL","VA139","pnca_complex.pdb"
|
|
"V139A","L4","PZA","V","V139",139,"A",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",5.113,-0.537,-1.598,2.24246,-2.438,-1.84,52,75,-1.171,9,9,0,0,"helix",0.733333333333333,9.18,0.0018686215322696,4.8698224852071,4.86982245520442,4.86909461472896,17.6365403604529,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,2,0,4,7,-0.136018237082067,-0.412919896640827,0.0816752744411017,-0.415686274509804,-0.481675392670157,0.547368421052632,-0.964579901153213,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","147/150","I:V:A",1.58305747959306,5.59300498642966e-05,0.392881092301541,4.02935521869819,2.23340951898872,10.6183850984524,0.687513130598596,0.0001170700255588,3.93155428682984,2.07661167855124,11.4195822840533,2.67400952353788e-05,"lineage4","dr_mutations_pyrazinamide","ALA",0,"SAMN02414962","SRR1163201_SRR1167131_SRR1163208_SRR1165432","lineage4.2.2","se","Sweden","pnca_p.val139ala","A","H","VAL","VA139","pnca_complex.pdb"
|
|
"V139A","L3","PZA","V","V139",139,"A",1,"Pre-MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",5.113,-0.537,-1.598,2.24246,-2.438,-1.84,52,75,-1.171,9,9,0,0,"helix",0.733333333333333,9.18,0.0018686215322696,4.8698224852071,4.86982245520442,4.86909461472896,17.6365403604529,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,2,0,4,7,-0.136018237082067,-0.412919896640827,0.0816752744411017,-0.415686274509804,-0.481675392670157,0.547368421052632,-0.964579901153213,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","147/150","I:V:A",1.58305747959306,5.59300498642966e-05,0.392881092301541,4.02935521869819,2.23340951898872,10.6183850984524,0.687513130598596,0.0001170700255588,3.93155428682984,2.07661167855124,11.4195822840533,2.67400952353788e-05,"lineage3","dr_mutations_pyrazinamide","ALA",0,"ERR2510295","ERR2510295","lineage3","pk","Pakistan","pnca_p.val139ala","A","H","VAL","VA139","pnca_complex.pdb"
|
|
"V139A","L3","PZA","V","V139",139,"A",0,"MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",5.113,-0.537,-1.598,2.24246,-2.438,-1.84,52,75,-1.171,9,9,0,0,"helix",0.733333333333333,9.18,0.0018686215322696,4.8698224852071,4.86982245520442,4.86909461472896,17.6365403604529,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,2,0,4,7,-0.136018237082067,-0.412919896640827,0.0816752744411017,-0.415686274509804,-0.481675392670157,0.547368421052632,-0.964579901153213,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","147/150","I:V:A",1.58305747959306,5.59300498642966e-05,0.392881092301541,4.02935521869819,2.23340951898872,10.6183850984524,0.687513130598596,0.0001170700255588,3.93155428682984,2.07661167855124,11.4195822840533,2.67400952353788e-05,"lineage3","dr_mutations_pyrazinamide","ALA",0,"ERR2510438","ERR2510438","lineage3","pk","Pakistan","pnca_p.val139ala","A","H","VAL","VA139","pnca_complex.pdb"
|
|
"V139A","L4","PZA","V","V139",139,"A",1,"MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",5.113,-0.537,-1.598,2.24246,-2.438,-1.84,52,75,-1.171,9,9,0,0,"helix",0.733333333333333,9.18,0.0018686215322696,4.8698224852071,4.86982245520442,4.86909461472896,17.6365403604529,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,2,0,4,7,-0.136018237082067,-0.412919896640827,0.0816752744411017,-0.415686274509804,-0.481675392670157,0.547368421052632,-0.964579901153213,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","147/150","I:V:A",1.58305747959306,5.59300498642966e-05,0.392881092301541,4.02935521869819,2.23340951898872,10.6183850984524,0.687513130598596,0.0001170700255588,3.93155428682984,2.07661167855124,11.4195822840533,2.67400952353788e-05,"lineage4","dr_mutations_pyrazinamide","ALA",0,"ERR2516607","ERR2516607","lineage4.1.2.1","nl","Netherlands","pnca_p.val139ala","A","H","VAL","VA139","pnca_complex.pdb"
|
|
"V139A","L2;L4","PZA","V","V139",139,"A",1,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",5.113,-0.537,-1.598,2.24246,-2.438,-1.84,52,75,-1.171,9,9,0,0,"helix",0.733333333333333,9.18,0.0018686215322696,4.8698224852071,4.86982245520442,4.86909461472896,17.6365403604529,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,2,0,4,7,-0.136018237082067,-0.412919896640827,0.0816752744411017,-0.415686274509804,-0.481675392670157,0.547368421052632,-0.964579901153213,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","147/150","I:V:A",1.58305747959306,5.59300498642966e-05,0.392881092301541,4.02935521869819,2.23340951898872,10.6183850984524,0.687513130598596,0.0001170700255588,3.93155428682984,2.07661167855124,11.4195822840533,2.67400952353788e-05,"lineage2;lineage4","dr_mutations_pyrazinamide","ALA",0,"ERR228042,2273X-sc-2012-10-11T13:38:28Z-1494206","ERR228042","lineage4;lineage2.2.1","ru","Russia,Samara","pnca_p.val139ala","A","H","VAL","VA139","pnca_complex.pdb"
|
|
"V139A","L4","PZA","V","V139",139,"A",0,"Pre-MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",5.113,-0.537,-1.598,2.24246,-2.438,-1.84,52,75,-1.171,9,9,0,0,"helix",0.733333333333333,9.18,0.0018686215322696,4.8698224852071,4.86982245520442,4.86909461472896,17.6365403604529,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,2,0,4,7,-0.136018237082067,-0.412919896640827,0.0816752744411017,-0.415686274509804,-0.481675392670157,0.547368421052632,-0.964579901153213,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","147/150","I:V:A",1.58305747959306,5.59300498642966e-05,0.392881092301541,4.02935521869819,2.23340951898872,10.6183850984524,0.687513130598596,0.0001170700255588,3.93155428682984,2.07661167855124,11.4195822840533,2.67400952353788e-05,"lineage4","dr_mutations_pyrazinamide","ALA",0,"SAMEA2534084,ERS457486","ERR551634_ERR551635","lineage4.8","uz","Nukus","pnca_p.val139ala","A","H","VAL","VA139","pnca_complex.pdb"
|
|
"V139A","L4","PZA","V","V139",139,"A",1,"MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",5.113,-0.537,-1.598,2.24246,-2.438,-1.84,52,75,-1.171,9,9,0,0,"helix",0.733333333333333,9.18,0.0018686215322696,4.8698224852071,4.86982245520442,4.86909461472896,17.6365403604529,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,2,0,4,7,-0.136018237082067,-0.412919896640827,0.0816752744411017,-0.415686274509804,-0.481675392670157,0.547368421052632,-0.964579901153213,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","147/150","I:V:A",1.58305747959306,5.59300498642966e-05,0.392881092301541,4.02935521869819,2.23340951898872,10.6183850984524,0.687513130598596,0.0001170700255588,3.93155428682984,2.07661167855124,11.4195822840533,2.67400952353788e-05,"lineage4","dr_mutations_pyrazinamide","ALA",0,"ERR2510726","ERR2510726","lineage4.8","it","Italy","pnca_p.val139ala","A","H","VAL","VA139","pnca_complex.pdb"
|
|
"V139A","L3","PZA","V","V139",139,"A",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",5.113,-0.537,-1.598,2.24246,-2.438,-1.84,52,75,-1.171,9,9,0,0,"helix",0.733333333333333,9.18,0.0018686215322696,4.8698224852071,4.86982245520442,4.86909461472896,17.6365403604529,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,2,0,4,7,-0.136018237082067,-0.412919896640827,0.0816752744411017,-0.415686274509804,-0.481675392670157,0.547368421052632,-0.964579901153213,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","147/150","I:V:A",1.58305747959306,5.59300498642966e-05,0.392881092301541,4.02935521869819,2.23340951898872,10.6183850984524,0.687513130598596,0.0001170700255588,3.93155428682984,2.07661167855124,11.4195822840533,2.67400952353788e-05,"lineage3","dr_mutations_pyrazinamide","ALA",0,"SAMN07658621","SRR6045141","lineage3","gb","UK","pnca_p.val139ala","A","H","VAL","VA139","pnca_complex.pdb"
|
|
"V139A","L4","PZA","V","V139",139,"A",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",5.113,-0.537,-1.598,2.24246,-2.438,-1.84,52,75,-1.171,9,9,0,0,"helix",0.733333333333333,9.18,0.0018686215322696,4.8698224852071,4.86982245520442,4.86909461472896,17.6365403604529,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,2,0,4,7,-0.136018237082067,-0.412919896640827,0.0816752744411017,-0.415686274509804,-0.481675392670157,0.547368421052632,-0.964579901153213,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","147/150","I:V:A",1.58305747959306,5.59300498642966e-05,0.392881092301541,4.02935521869819,2.23340951898872,10.6183850984524,0.687513130598596,0.0001170700255588,3.93155428682984,2.07661167855124,11.4195822840533,2.67400952353788e-05,"lineage4","dr_mutations_pyrazinamide","ALA",0,"SAMN01925685","SRR847798_SRR924237","lineage4.1.2.1","za","South Africa","pnca_p.val139ala","A","H","VAL","VA139","pnca_complex.pdb"
|
|
"V139A","L2","PZA","V","V139",139,"A",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",5.113,-0.537,-1.598,2.24246,-2.438,-1.84,52,75,-1.171,9,9,0,0,"helix",0.733333333333333,9.18,0.0018686215322696,4.8698224852071,4.86982245520442,4.86909461472896,17.6365403604529,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,2,0,4,7,-0.136018237082067,-0.412919896640827,0.0816752744411017,-0.415686274509804,-0.481675392670157,0.547368421052632,-0.964579901153213,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","147/150","I:V:A",1.58305747959306,5.59300498642966e-05,0.392881092301541,4.02935521869819,2.23340951898872,10.6183850984524,0.687513130598596,0.0001170700255588,3.93155428682984,2.07661167855124,11.4195822840533,2.67400952353788e-05,"lineage2","dr_mutations_pyrazinamide","ALA",0,"SRR5709893,SAMN07236312","SRR5709893","lineage2.2.1","th","Thailand","pnca_p.val139ala","A","H","VAL","VA139","pnca_complex.pdb"
|
|
"V139A","L2","PZA","V","V139",139,"A",NA,"XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",5.113,-0.537,-1.598,2.24246,-2.438,-1.84,52,75,-1.171,9,9,0,0,"helix",0.733333333333333,9.18,0.0018686215322696,4.8698224852071,4.86982245520442,4.86909461472896,17.6365403604529,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,2,0,4,7,-0.136018237082067,-0.412919896640827,0.0816752744411017,-0.415686274509804,-0.481675392670157,0.547368421052632,-0.964579901153213,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","147/150","I:V:A",1.58305747959306,5.59300498642966e-05,0.392881092301541,4.02935521869819,2.23340951898872,10.6183850984524,0.687513130598596,0.0001170700255588,3.93155428682984,2.07661167855124,11.4195822840533,2.67400952353788e-05,"lineage2","dr_mutations_pyrazinamide","ALA",0,"SAMN02628487","SRR1173311","lineage2.2.1","ir","Iran","pnca_p.val139ala","A","H","VAL","VA139","pnca_complex.pdb"
|
|
"V139A","L2","PZA","V","V139",139,"A",0,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",5.113,-0.537,-1.598,2.24246,-2.438,-1.84,52,75,-1.171,9,9,0,0,"helix",0.733333333333333,9.18,0.0018686215322696,4.8698224852071,4.86982245520442,4.86909461472896,17.6365403604529,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,2,0,4,7,-0.136018237082067,-0.412919896640827,0.0816752744411017,-0.415686274509804,-0.481675392670157,0.547368421052632,-0.964579901153213,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","147/150","I:V:A",1.58305747959306,5.59300498642966e-05,0.392881092301541,4.02935521869819,2.23340951898872,10.6183850984524,0.687513130598596,0.0001170700255588,3.93155428682984,2.07661167855124,11.4195822840533,2.67400952353788e-05,"lineage2","dr_mutations_pyrazinamide","ALA",0,"0460B-sc-2011-09-07T13:19:20Z-1276477,ERR067630","ERR067630","lineage2.2.1","ru","Russia,Samara","pnca_p.val139ala","A","H","VAL","VA139","pnca_complex.pdb"
|
|
"V139A","L2","PZA","V","V139",139,"A",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",5.113,-0.537,-1.598,2.24246,-2.438,-1.84,52,75,-1.171,9,9,0,0,"helix",0.733333333333333,9.18,0.0018686215322696,4.8698224852071,4.86982245520442,4.86909461472896,17.6365403604529,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,2,0,4,7,-0.136018237082067,-0.412919896640827,0.0816752744411017,-0.415686274509804,-0.481675392670157,0.547368421052632,-0.964579901153213,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","147/150","I:V:A",1.58305747959306,5.59300498642966e-05,0.392881092301541,4.02935521869819,2.23340951898872,10.6183850984524,0.687513130598596,0.0001170700255588,3.93155428682984,2.07661167855124,11.4195822840533,2.67400952353788e-05,"lineage2","dr_mutations_pyrazinamide","ALA",0,"SAMN07659943","SRR6044837","lineage2.2.1.1","gb","UK","pnca_p.val139ala","A","H","VAL","VA139","pnca_complex.pdb"
|
|
"V139A","L2","PZA","V","V139",139,"A",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",5.113,-0.537,-1.598,2.24246,-2.438,-1.84,52,75,-1.171,9,9,0,0,"helix",0.733333333333333,9.18,0.0018686215322696,4.8698224852071,4.86982245520442,4.86909461472896,17.6365403604529,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,2,0,4,7,-0.136018237082067,-0.412919896640827,0.0816752744411017,-0.415686274509804,-0.481675392670157,0.547368421052632,-0.964579901153213,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","147/150","I:V:A",1.58305747959306,5.59300498642966e-05,0.392881092301541,4.02935521869819,2.23340951898872,10.6183850984524,0.687513130598596,0.0001170700255588,3.93155428682984,2.07661167855124,11.4195822840533,2.67400952353788e-05,"lineage2","dr_mutations_pyrazinamide","ALA",0,"SRS936015,SAMN03653275","SRR2024974","lineage2.2.1","cn","China","pnca_p.val139ala","A","H","VAL","VA139","pnca_complex.pdb"
|
|
"V139A","L4","PZA","V","V139",139,"A",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",5.113,-0.537,-1.598,2.24246,-2.438,-1.84,52,75,-1.171,9,9,0,0,"helix",0.733333333333333,9.18,0.0018686215322696,4.8698224852071,4.86982245520442,4.86909461472896,17.6365403604529,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,2,0,4,7,-0.136018237082067,-0.412919896640827,0.0816752744411017,-0.415686274509804,-0.481675392670157,0.547368421052632,-0.964579901153213,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","147/150","I:V:A",1.58305747959306,5.59300498642966e-05,0.392881092301541,4.02935521869819,2.23340951898872,10.6183850984524,0.687513130598596,0.0001170700255588,3.93155428682984,2.07661167855124,11.4195822840533,2.67400952353788e-05,"lineage4","dr_mutations_pyrazinamide","ALA",0,"ERR2707183","ERR2707183","lineage4.6.1.2","cd","Democratic Republic of Congo","pnca_p.val139ala","A","H","VAL","VA139","pnca_complex.pdb"
|
|
"V139A","L2","PZA","V","V139",139,"A",1,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",5.113,-0.537,-1.598,2.24246,-2.438,-1.84,52,75,-1.171,9,9,0,0,"helix",0.733333333333333,9.18,0.0018686215322696,4.8698224852071,4.86982245520442,4.86909461472896,17.6365403604529,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,2,0,4,7,-0.136018237082067,-0.412919896640827,0.0816752744411017,-0.415686274509804,-0.481675392670157,0.547368421052632,-0.964579901153213,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","147/150","I:V:A",1.58305747959306,5.59300498642966e-05,0.392881092301541,4.02935521869819,2.23340951898872,10.6183850984524,0.687513130598596,0.0001170700255588,3.93155428682984,2.07661167855124,11.4195822840533,2.67400952353788e-05,"lineage2","dr_mutations_pyrazinamide","ALA",0,"ERR2517122","ERR2517122","lineage2.2.1.1","gb","UK","pnca_p.val139ala","A","H","VAL","VA139","pnca_complex.pdb"
|
|
"V139A","L2","PZA","V","V139",139,"A",0,"XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",5.113,-0.537,-1.598,2.24246,-2.438,-1.84,52,75,-1.171,9,9,0,0,"helix",0.733333333333333,9.18,0.0018686215322696,4.8698224852071,4.86982245520442,4.86909461472896,17.6365403604529,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,2,0,4,7,-0.136018237082067,-0.412919896640827,0.0816752744411017,-0.415686274509804,-0.481675392670157,0.547368421052632,-0.964579901153213,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","147/150","I:V:A",1.58305747959306,5.59300498642966e-05,0.392881092301541,4.02935521869819,2.23340951898872,10.6183850984524,0.687513130598596,0.0001170700255588,3.93155428682984,2.07661167855124,11.4195822840533,2.67400952353788e-05,"lineage2","dr_mutations_pyrazinamide","ALA",0,"0511G-sc-2011-08-25T12:38:46Z-1262360,ERR067761","ERR067761","lineage2.2.1","ru","Russia,Samara","pnca_p.val139ala","A","H","VAL","VA139","pnca_complex.pdb"
|
|
"V139A","L2","PZA","V","V139",139,"A",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",5.113,-0.537,-1.598,2.24246,-2.438,-1.84,52,75,-1.171,9,9,0,0,"helix",0.733333333333333,9.18,0.0018686215322696,4.8698224852071,4.86982245520442,4.86909461472896,17.6365403604529,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,2,0,4,7,-0.136018237082067,-0.412919896640827,0.0816752744411017,-0.415686274509804,-0.481675392670157,0.547368421052632,-0.964579901153213,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","147/150","I:V:A",1.58305747959306,5.59300498642966e-05,0.392881092301541,4.02935521869819,2.23340951898872,10.6183850984524,0.687513130598596,0.0001170700255588,3.93155428682984,2.07661167855124,11.4195822840533,2.67400952353788e-05,"lineage2","dr_mutations_pyrazinamide","ALA",0,"ETB0095","SRR6257021","lineage2.2.1","ru","Russia:Buryatia","pnca_p.val139ala","A","H","VAL","VA139","pnca_complex.pdb"
|
|
"V139A","L2","PZA","V","V139",139,"A",0,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",5.113,-0.537,-1.598,2.24246,-2.438,-1.84,52,75,-1.171,9,9,0,0,"helix",0.733333333333333,9.18,0.0018686215322696,4.8698224852071,4.86982245520442,4.86909461472896,17.6365403604529,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,2,0,4,7,-0.136018237082067,-0.412919896640827,0.0816752744411017,-0.415686274509804,-0.481675392670157,0.547368421052632,-0.964579901153213,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","147/150","I:V:A",1.58305747959306,5.59300498642966e-05,0.392881092301541,4.02935521869819,2.23340951898872,10.6183850984524,0.687513130598596,0.0001170700255588,3.93155428682984,2.07661167855124,11.4195822840533,2.67400952353788e-05,"lineage2","dr_mutations_pyrazinamide","ALA",0,"2028F-sc-2012-02-21T11:38:20Z-1364856,ERR144619","ERR144619","lineage2.2.1","ru","Russia,Samara","pnca_p.val139ala","A","H","VAL","VA139","pnca_complex.pdb"
|
|
"V139A","L3","PZA","V","V139",139,"A",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",5.113,-0.537,-1.598,2.24246,-2.438,-1.84,52,75,-1.171,9,9,0,0,"helix",0.733333333333333,9.18,0.0018686215322696,4.8698224852071,4.86982245520442,4.86909461472896,17.6365403604529,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,2,0,4,7,-0.136018237082067,-0.412919896640827,0.0816752744411017,-0.415686274509804,-0.481675392670157,0.547368421052632,-0.964579901153213,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","147/150","I:V:A",1.58305747959306,5.59300498642966e-05,0.392881092301541,4.02935521869819,2.23340951898872,10.6183850984524,0.687513130598596,0.0001170700255588,3.93155428682984,2.07661167855124,11.4195822840533,2.67400952353788e-05,"lineage3","dr_mutations_pyrazinamide","ALA",0,"SAMN02628506","SRR1173572_SRR1173751","lineage3","ir","Iran","pnca_p.val139ala","A","H","VAL","VA139","pnca_complex.pdb"
|
|
"V139A","L4","PZA","V","V139",139,"A",1,"MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",5.113,-0.537,-1.598,2.24246,-2.438,-1.84,52,75,-1.171,9,9,0,0,"helix",0.733333333333333,9.18,0.0018686215322696,4.8698224852071,4.86982245520442,4.86909461472896,17.6365403604529,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,2,0,4,7,-0.136018237082067,-0.412919896640827,0.0816752744411017,-0.415686274509804,-0.481675392670157,0.547368421052632,-0.964579901153213,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","147/150","I:V:A",1.58305747959306,5.59300498642966e-05,0.392881092301541,4.02935521869819,2.23340951898872,10.6183850984524,0.687513130598596,0.0001170700255588,3.93155428682984,2.07661167855124,11.4195822840533,2.67400952353788e-05,"lineage4","dr_mutations_pyrazinamide","ALA",0,"ERR2515997","ERR2515997","lineage4.4.1.1","za","South Africa","pnca_p.val139ala","A","H","VAL","VA139","pnca_complex.pdb"
|
|
"V139A","L1","PZA","V","V139",139,"A",1,"MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",5.113,-0.537,-1.598,2.24246,-2.438,-1.84,52,75,-1.171,9,9,0,0,"helix",0.733333333333333,9.18,0.0018686215322696,4.8698224852071,4.86982245520442,4.86909461472896,17.6365403604529,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,2,0,4,7,-0.136018237082067,-0.412919896640827,0.0816752744411017,-0.415686274509804,-0.481675392670157,0.547368421052632,-0.964579901153213,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","147/150","I:V:A",1.58305747959306,5.59300498642966e-05,0.392881092301541,4.02935521869819,2.23340951898872,10.6183850984524,0.687513130598596,0.0001170700255588,3.93155428682984,2.07661167855124,11.4195822840533,2.67400952353788e-05,"lineage1","dr_mutations_pyrazinamide","ALA",0,"ERR2510593","ERR2510593","lineage1.1.2","pk","Pakistan","pnca_p.val139ala","A","H","VAL","VA139","pnca_complex.pdb"
|
|
"V139A","L2","PZA","V","V139",139,"A",0,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",5.113,-0.537,-1.598,2.24246,-2.438,-1.84,52,75,-1.171,9,9,0,0,"helix",0.733333333333333,9.18,0.0018686215322696,4.8698224852071,4.86982245520442,4.86909461472896,17.6365403604529,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,2,0,4,7,-0.136018237082067,-0.412919896640827,0.0816752744411017,-0.415686274509804,-0.481675392670157,0.547368421052632,-0.964579901153213,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","147/150","I:V:A",1.58305747959306,5.59300498642966e-05,0.392881092301541,4.02935521869819,2.23340951898872,10.6183850984524,0.687513130598596,0.0001170700255588,3.93155428682984,2.07661167855124,11.4195822840533,2.67400952353788e-05,"lineage2","dr_mutations_pyrazinamide","ALA",0,"ERR2513852","ERR2513852","lineage2.2.1.1","gb","UK","pnca_p.val139ala","A","H","VAL","VA139","pnca_complex.pdb"
|
|
"V139A","L2","PZA","V","V139",139,"A",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",5.113,-0.537,-1.598,2.24246,-2.438,-1.84,52,75,-1.171,9,9,0,0,"helix",0.733333333333333,9.18,0.0018686215322696,4.8698224852071,4.86982245520442,4.86909461472896,17.6365403604529,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,2,0,4,7,-0.136018237082067,-0.412919896640827,0.0816752744411017,-0.415686274509804,-0.481675392670157,0.547368421052632,-0.964579901153213,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","147/150","I:V:A",1.58305747959306,5.59300498642966e-05,0.392881092301541,4.02935521869819,2.23340951898872,10.6183850984524,0.687513130598596,0.0001170700255588,3.93155428682984,2.07661167855124,11.4195822840533,2.67400952353788e-05,"lineage2","dr_mutations_pyrazinamide","ALA",0,"ERR1035090","ERR1035090","lineage2.2.1","vn","Vietnam","pnca_p.val139ala","A","H","VAL","VA139","pnca_complex.pdb"
|
|
"V139A","L4","PZA","V","V139",139,"A",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",5.113,-0.537,-1.598,2.24246,-2.438,-1.84,52,75,-1.171,9,9,0,0,"helix",0.733333333333333,9.18,0.0018686215322696,4.8698224852071,4.86982245520442,4.86909461472896,17.6365403604529,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,2,0,4,7,-0.136018237082067,-0.412919896640827,0.0816752744411017,-0.415686274509804,-0.481675392670157,0.547368421052632,-0.964579901153213,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","147/150","I:V:A",1.58305747959306,5.59300498642966e-05,0.392881092301541,4.02935521869819,2.23340951898872,10.6183850984524,0.687513130598596,0.0001170700255588,3.93155428682984,2.07661167855124,11.4195822840533,2.67400952353788e-05,"lineage4","dr_mutations_pyrazinamide","ALA",0,"SAMN02567711","SRR1166316","lineage4.1.2.1","ro","Romania","pnca_p.val139ala","A","H","VAL","VA139","pnca_complex.pdb"
|
|
"V139A","L4","PZA","V","V139",139,"A",0,"MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",5.113,-0.537,-1.598,2.24246,-2.438,-1.84,52,75,-1.171,9,9,0,0,"helix",0.733333333333333,9.18,0.0018686215322696,4.8698224852071,4.86982245520442,4.86909461472896,17.6365403604529,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,2,0,4,7,-0.136018237082067,-0.412919896640827,0.0816752744411017,-0.415686274509804,-0.481675392670157,0.547368421052632,-0.964579901153213,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","147/150","I:V:A",1.58305747959306,5.59300498642966e-05,0.392881092301541,4.02935521869819,2.23340951898872,10.6183850984524,0.687513130598596,0.0001170700255588,3.93155428682984,2.07661167855124,11.4195822840533,2.67400952353788e-05,"lineage4","dr_mutations_pyrazinamide","ALA",0,"ERR2516961","ERR2516961","lineage4.1.1.3","gb","UK","pnca_p.val139ala","A","H","VAL","VA139","pnca_complex.pdb"
|
|
"V139A","L2","PZA","V","V139",139,"A",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",5.113,-0.537,-1.598,2.24246,-2.438,-1.84,52,75,-1.171,9,9,0,0,"helix",0.733333333333333,9.18,0.0018686215322696,4.8698224852071,4.86982245520442,4.86909461472896,17.6365403604529,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,2,0,4,7,-0.136018237082067,-0.412919896640827,0.0816752744411017,-0.415686274509804,-0.481675392670157,0.547368421052632,-0.964579901153213,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","147/150","I:V:A",1.58305747959306,5.59300498642966e-05,0.392881092301541,4.02935521869819,2.23340951898872,10.6183850984524,0.687513130598596,0.0001170700255588,3.93155428682984,2.07661167855124,11.4195822840533,2.67400952353788e-05,"lineage2","dr_mutations_pyrazinamide","ALA",0,"SAMN03653206,SRS935999","SRR2024957","lineage2.2.1","cn","China","pnca_p.val139ala","A","H","VAL","VA139","pnca_complex.pdb"
|
|
"V139A","L2","PZA","V","V139",139,"A",1,"XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",5.113,-0.537,-1.598,2.24246,-2.438,-1.84,52,75,-1.171,9,9,0,0,"helix",0.733333333333333,9.18,0.0018686215322696,4.8698224852071,4.86982245520442,4.86909461472896,17.6365403604529,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,2,0,4,7,-0.136018237082067,-0.412919896640827,0.0816752744411017,-0.415686274509804,-0.481675392670157,0.547368421052632,-0.964579901153213,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","147/150","I:V:A",1.58305747959306,5.59300498642966e-05,0.392881092301541,4.02935521869819,2.23340951898872,10.6183850984524,0.687513130598596,0.0001170700255588,3.93155428682984,2.07661167855124,11.4195822840533,2.67400952353788e-05,"lineage2","dr_mutations_pyrazinamide","ALA",0,"ERS2592785","ERR2677439","lineage2.2.1","de","Germany","pnca_p.val139ala","A","H","VAL","VA139","pnca_complex.pdb"
|
|
"V139A","L2","PZA","V","V139",139,"A",0,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",5.113,-0.537,-1.598,2.24246,-2.438,-1.84,52,75,-1.171,9,9,0,0,"helix",0.733333333333333,9.18,0.0018686215322696,4.8698224852071,4.86982245520442,4.86909461472896,17.6365403604529,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,2,0,4,7,-0.136018237082067,-0.412919896640827,0.0816752744411017,-0.415686274509804,-0.481675392670157,0.547368421052632,-0.964579901153213,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","147/150","I:V:A",1.58305747959306,5.59300498642966e-05,0.392881092301541,4.02935521869819,2.23340951898872,10.6183850984524,0.687513130598596,0.0001170700255588,3.93155428682984,2.07661167855124,11.4195822840533,2.67400952353788e-05,"lineage2","dr_mutations_pyrazinamide","ALA",0,"0943B-sc-2011-09-07T13:19:28Z-1276490,ERR067643","ERR067643","lineage2.2.1","ru","Russia,Samara","pnca_p.val139ala","A","H","VAL","VA139","pnca_complex.pdb"
|
|
"V139G","L4","PZA","V","V139",139,"G",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",5.113,-0.4,-2.377,4.03008,-4.222,-2.37,84,91,-1.171,9,9,0,0,"helix",0.733333333333333,9.18,0.000646830530401,38.9169126950654,38.9169126367817,38.9145296299157,27.8738145664613,12,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,6,0,17,25,-0.101317122593718,-0.61421188630491,0.146784286016069,-0.719863597612958,-0.620418848167539,0.884210526315789,-0.964579901153213,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","147/150","I:V:A",3.66142892829214,0.0005578275078108,1.06087424525349,3.45133171502081,7.13685172053903,722.165073758294,1.59013838008863,5.5228318480997e-06,5.25783817940065,5.21074959149254,1710.75565736304,1.29490403629991e-07,"lineage4","dr_mutations_pyrazinamide","GLY",0,"SAMN01828249","SRR833062_SRR833186_SRR833060_SRR833123_SRR832980","lineage4.3.3","za","South Africa","pnca_p.val139gly","A","H","VAL","VA139","pnca_complex.pdb"
|
|
"V139G","L4","PZA","V","V139",139,"G",NA,"XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",5.113,-0.4,-2.377,4.03008,-4.222,-2.37,84,91,-1.171,9,9,0,0,"helix",0.733333333333333,9.18,0.000646830530401,38.9169126950654,38.9169126367817,38.9145296299157,27.8738145664613,12,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,6,0,17,25,-0.101317122593718,-0.61421188630491,0.146784286016069,-0.719863597612958,-0.620418848167539,0.884210526315789,-0.964579901153213,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","147/150","I:V:A",3.66142892829214,0.0005578275078108,1.06087424525349,3.45133171502081,7.13685172053903,722.165073758294,1.59013838008863,5.5228318480997e-06,5.25783817940065,5.21074959149254,1710.75565736304,1.29490403629991e-07,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR3148169","ERR3148169","lineage4.1.2.1","mx","Mexico","pnca_p.val139gly","A","H","VAL","VA139","pnca_complex.pdb"
|
|
"V139G","L4","PZA","V","V139",139,"G",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",5.113,-0.4,-2.377,4.03008,-4.222,-2.37,84,91,-1.171,9,9,0,0,"helix",0.733333333333333,9.18,0.000646830530401,38.9169126950654,38.9169126367817,38.9145296299157,27.8738145664613,12,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,6,0,17,25,-0.101317122593718,-0.61421188630491,0.146784286016069,-0.719863597612958,-0.620418848167539,0.884210526315789,-0.964579901153213,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","147/150","I:V:A",3.66142892829214,0.0005578275078108,1.06087424525349,3.45133171502081,7.13685172053903,722.165073758294,1.59013838008863,5.5228318480997e-06,5.25783817940065,5.21074959149254,1710.75565736304,1.29490403629991e-07,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR1193882","ERR1193882","lineage4.3.3","za","South Africa","pnca_p.val139gly","A","H","VAL","VA139","pnca_complex.pdb"
|
|
"V139G","L4","PZA","V","V139",139,"G",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",5.113,-0.4,-2.377,4.03008,-4.222,-2.37,84,91,-1.171,9,9,0,0,"helix",0.733333333333333,9.18,0.000646830530401,38.9169126950654,38.9169126367817,38.9145296299157,27.8738145664613,12,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,6,0,17,25,-0.101317122593718,-0.61421188630491,0.146784286016069,-0.719863597612958,-0.620418848167539,0.884210526315789,-0.964579901153213,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","147/150","I:V:A",3.66142892829214,0.0005578275078108,1.06087424525349,3.45133171502081,7.13685172053903,722.165073758294,1.59013838008863,5.5228318480997e-06,5.25783817940065,5.21074959149254,1710.75565736304,1.29490403629991e-07,"lineage4","dr_mutations_pyrazinamide","GLY",0,"SAMN02585969","SRR1181219_SRR1181218_SRR1183035_SRR1180258","lineage4.3.3","za","South Africa","pnca_p.val139gly","A","H","VAL","VA139","pnca_complex.pdb"
|
|
"V139G","L2","PZA","V","V139",139,"G",NA,"XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",5.113,-0.4,-2.377,4.03008,-4.222,-2.37,84,91,-1.171,9,9,0,0,"helix",0.733333333333333,9.18,0.000646830530401,38.9169126950654,38.9169126367817,38.9145296299157,27.8738145664613,12,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,6,0,17,25,-0.101317122593718,-0.61421188630491,0.146784286016069,-0.719863597612958,-0.620418848167539,0.884210526315789,-0.964579901153213,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","147/150","I:V:A",3.66142892829214,0.0005578275078108,1.06087424525349,3.45133171502081,7.13685172053903,722.165073758294,1.59013838008863,5.5228318480997e-06,5.25783817940065,5.21074959149254,1710.75565736304,1.29490403629991e-07,"lineage2","dr_mutations_pyrazinamide","GLY",0,"ETB0058","SRR6256985","lineage2.2.1","ru","Russia:Moscow Region","pnca_p.val139gly","A","H","VAL","VA139","pnca_complex.pdb"
|
|
"V139G","L4","PZA","V","V139",139,"G",1,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",5.113,-0.4,-2.377,4.03008,-4.222,-2.37,84,91,-1.171,9,9,0,0,"helix",0.733333333333333,9.18,0.000646830530401,38.9169126950654,38.9169126367817,38.9145296299157,27.8738145664613,12,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,6,0,17,25,-0.101317122593718,-0.61421188630491,0.146784286016069,-0.719863597612958,-0.620418848167539,0.884210526315789,-0.964579901153213,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","147/150","I:V:A",3.66142892829214,0.0005578275078108,1.06087424525349,3.45133171502081,7.13685172053903,722.165073758294,1.59013838008863,5.5228318480997e-06,5.25783817940065,5.21074959149254,1710.75565736304,1.29490403629991e-07,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR2515948","ERR2515948","lineage4.3.3","za","South Africa","pnca_p.val139gly","A","H","VAL","VA139","pnca_complex.pdb"
|
|
"V139G","L2","PZA","V","V139",139,"G",1,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",5.113,-0.4,-2.377,4.03008,-4.222,-2.37,84,91,-1.171,9,9,0,0,"helix",0.733333333333333,9.18,0.000646830530401,38.9169126950654,38.9169126367817,38.9145296299157,27.8738145664613,12,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,6,0,17,25,-0.101317122593718,-0.61421188630491,0.146784286016069,-0.719863597612958,-0.620418848167539,0.884210526315789,-0.964579901153213,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","147/150","I:V:A",3.66142892829214,0.0005578275078108,1.06087424525349,3.45133171502081,7.13685172053903,722.165073758294,1.59013838008863,5.5228318480997e-06,5.25783817940065,5.21074959149254,1710.75565736304,1.29490403629991e-07,"lineage2","dr_mutations_pyrazinamide","GLY",0,"MDR_15129","SRR6824427","lineage2.2.1","cn","China: Zhoucun District, Zibo City, Shandong Province","pnca_p.val139gly","A","H","VAL","VA139","pnca_complex.pdb"
|
|
"V139G","L2","PZA","V","V139",139,"G",1,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",5.113,-0.4,-2.377,4.03008,-4.222,-2.37,84,91,-1.171,9,9,0,0,"helix",0.733333333333333,9.18,0.000646830530401,38.9169126950654,38.9169126367817,38.9145296299157,27.8738145664613,12,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,6,0,17,25,-0.101317122593718,-0.61421188630491,0.146784286016069,-0.719863597612958,-0.620418848167539,0.884210526315789,-0.964579901153213,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","147/150","I:V:A",3.66142892829214,0.0005578275078108,1.06087424525349,3.45133171502081,7.13685172053903,722.165073758294,1.59013838008863,5.5228318480997e-06,5.25783817940065,5.21074959149254,1710.75565736304,1.29490403629991e-07,"lineage2","dr_mutations_pyrazinamide","GLY",0,"MDR_16351","SRR6824694","lineage2.2.1","cn","China: Xinmi City, Zhengzhou City, Henan Province","pnca_p.val139gly","A","H","VAL","VA139","pnca_complex.pdb"
|
|
"V139G","L2","PZA","V","V139",139,"G",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",5.113,-0.4,-2.377,4.03008,-4.222,-2.37,84,91,-1.171,9,9,0,0,"helix",0.733333333333333,9.18,0.000646830530401,38.9169126950654,38.9169126367817,38.9145296299157,27.8738145664613,12,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,6,0,17,25,-0.101317122593718,-0.61421188630491,0.146784286016069,-0.719863597612958,-0.620418848167539,0.884210526315789,-0.964579901153213,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","147/150","I:V:A",3.66142892829214,0.0005578275078108,1.06087424525349,3.45133171502081,7.13685172053903,722.165073758294,1.59013838008863,5.5228318480997e-06,5.25783817940065,5.21074959149254,1710.75565736304,1.29490403629991e-07,"lineage2","dr_mutations_pyrazinamide","GLY",0,"SRS797038","SRR1723538","lineage2.2.1","cn","China:Henan","pnca_p.val139gly","A","H","VAL","VA139","pnca_complex.pdb"
|
|
"V139G","L2","PZA","V","V139",139,"G",0,"XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",5.113,-0.4,-2.377,4.03008,-4.222,-2.37,84,91,-1.171,9,9,0,0,"helix",0.733333333333333,9.18,0.000646830530401,38.9169126950654,38.9169126367817,38.9145296299157,27.8738145664613,12,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,6,0,17,25,-0.101317122593718,-0.61421188630491,0.146784286016069,-0.719863597612958,-0.620418848167539,0.884210526315789,-0.964579901153213,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","147/150","I:V:A",3.66142892829214,0.0005578275078108,1.06087424525349,3.45133171502081,7.13685172053903,722.165073758294,1.59013838008863,5.5228318480997e-06,5.25783817940065,5.21074959149254,1710.75565736304,1.29490403629991e-07,"lineage2","dr_mutations_pyrazinamide","GLY",0,"ERR067653,0831E-sc-2011-09-07T13:19:33Z-1276500","ERR067653","lineage2.2.1","ru","Russia,Samara","pnca_p.val139gly","A","H","VAL","VA139","pnca_complex.pdb"
|
|
"V139G","L4","PZA","V","V139",139,"G",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",5.113,-0.4,-2.377,4.03008,-4.222,-2.37,84,91,-1.171,9,9,0,0,"helix",0.733333333333333,9.18,0.000646830530401,38.9169126950654,38.9169126367817,38.9145296299157,27.8738145664613,12,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,6,0,17,25,-0.101317122593718,-0.61421188630491,0.146784286016069,-0.719863597612958,-0.620418848167539,0.884210526315789,-0.964579901153213,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","147/150","I:V:A",3.66142892829214,0.0005578275078108,1.06087424525349,3.45133171502081,7.13685172053903,722.165073758294,1.59013838008863,5.5228318480997e-06,5.25783817940065,5.21074959149254,1710.75565736304,1.29490403629991e-07,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR3256263","ERR3256263","lineage4.3.4.1","ph","Philippines","pnca_p.val139gly","A","H","VAL","VA139","pnca_complex.pdb"
|
|
"V139G","L2","PZA","V","V139",139,"G",1,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",5.113,-0.4,-2.377,4.03008,-4.222,-2.37,84,91,-1.171,9,9,0,0,"helix",0.733333333333333,9.18,0.000646830530401,38.9169126950654,38.9169126367817,38.9145296299157,27.8738145664613,12,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,6,0,17,25,-0.101317122593718,-0.61421188630491,0.146784286016069,-0.719863597612958,-0.620418848167539,0.884210526315789,-0.964579901153213,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","147/150","I:V:A",3.66142892829214,0.0005578275078108,1.06087424525349,3.45133171502081,7.13685172053903,722.165073758294,1.59013838008863,5.5228318480997e-06,5.25783817940065,5.21074959149254,1710.75565736304,1.29490403629991e-07,"lineage2","dr_mutations_pyrazinamide","GLY",0,"SAMN10961382","SRR8651621","lineage2.2.1","cn","China:Wenzhou","pnca_p.val139gly","A","H","VAL","VA139","pnca_complex.pdb"
|
|
"V139G","L2","PZA","V","V139",139,"G",NA,"XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",5.113,-0.4,-2.377,4.03008,-4.222,-2.37,84,91,-1.171,9,9,0,0,"helix",0.733333333333333,9.18,0.000646830530401,38.9169126950654,38.9169126367817,38.9145296299157,27.8738145664613,12,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,6,0,17,25,-0.101317122593718,-0.61421188630491,0.146784286016069,-0.719863597612958,-0.620418848167539,0.884210526315789,-0.964579901153213,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","147/150","I:V:A",3.66142892829214,0.0005578275078108,1.06087424525349,3.45133171502081,7.13685172053903,722.165073758294,1.59013838008863,5.5228318480997e-06,5.25783817940065,5.21074959149254,1710.75565736304,1.29490403629991e-07,"lineage2","dr_mutations_pyrazinamide","GLY",0,"ETB0094","SRR6257022","lineage2.2.1","ru","Russia:Moscow Region","pnca_p.val139gly","A","H","VAL","VA139","pnca_complex.pdb"
|
|
"V139G","L2","PZA","V","V139",139,"G",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",5.113,-0.4,-2.377,4.03008,-4.222,-2.37,84,91,-1.171,9,9,0,0,"helix",0.733333333333333,9.18,0.000646830530401,38.9169126950654,38.9169126367817,38.9145296299157,27.8738145664613,12,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,6,0,17,25,-0.101317122593718,-0.61421188630491,0.146784286016069,-0.719863597612958,-0.620418848167539,0.884210526315789,-0.964579901153213,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","147/150","I:V:A",3.66142892829214,0.0005578275078108,1.06087424525349,3.45133171502081,7.13685172053903,722.165073758294,1.59013838008863,5.5228318480997e-06,5.25783817940065,5.21074959149254,1710.75565736304,1.29490403629991e-07,"lineage2","dr_mutations_pyrazinamide","GLY",0,"SRR6397671","SRR6397671","lineage2.2.1.1","ca","Canada","pnca_p.val139gly","A","H","VAL","VA139","pnca_complex.pdb"
|
|
"V139G","L3","PZA","V","V139",139,"G",1,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",5.113,-0.4,-2.377,4.03008,-4.222,-2.37,84,91,-1.171,9,9,0,0,"helix",0.733333333333333,9.18,0.000646830530401,38.9169126950654,38.9169126367817,38.9145296299157,27.8738145664613,12,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,6,0,17,25,-0.101317122593718,-0.61421188630491,0.146784286016069,-0.719863597612958,-0.620418848167539,0.884210526315789,-0.964579901153213,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","147/150","I:V:A",3.66142892829214,0.0005578275078108,1.06087424525349,3.45133171502081,7.13685172053903,722.165073758294,1.59013838008863,5.5228318480997e-06,5.25783817940065,5.21074959149254,1710.75565736304,1.29490403629991e-07,"lineage3","dr_mutations_pyrazinamide","GLY",0,"ERR2510487","ERR2510487","lineage3","pk","Pakistan","pnca_p.val139gly","A","H","VAL","VA139","pnca_complex.pdb"
|
|
"V139G","L2","PZA","V","V139",139,"G",1,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",5.113,-0.4,-2.377,4.03008,-4.222,-2.37,84,91,-1.171,9,9,0,0,"helix",0.733333333333333,9.18,0.000646830530401,38.9169126950654,38.9169126367817,38.9145296299157,27.8738145664613,12,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,6,0,17,25,-0.101317122593718,-0.61421188630491,0.146784286016069,-0.719863597612958,-0.620418848167539,0.884210526315789,-0.964579901153213,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","147/150","I:V:A",3.66142892829214,0.0005578275078108,1.06087424525349,3.45133171502081,7.13685172053903,722.165073758294,1.59013838008863,5.5228318480997e-06,5.25783817940065,5.21074959149254,1710.75565736304,1.29490403629991e-07,"lineage2","dr_mutations_pyrazinamide","GLY",0,"ERR2516373","ERR2516373","lineage2.2.1","be","Belgium","pnca_p.val139gly","A","H","VAL","VA139","pnca_complex.pdb"
|
|
"V139G","L4","PZA","V","V139",139,"G",1,"XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",5.113,-0.4,-2.377,4.03008,-4.222,-2.37,84,91,-1.171,9,9,0,0,"helix",0.733333333333333,9.18,0.000646830530401,38.9169126950654,38.9169126367817,38.9145296299157,27.8738145664613,12,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,6,0,17,25,-0.101317122593718,-0.61421188630491,0.146784286016069,-0.719863597612958,-0.620418848167539,0.884210526315789,-0.964579901153213,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","147/150","I:V:A",3.66142892829214,0.0005578275078108,1.06087424525349,3.45133171502081,7.13685172053903,722.165073758294,1.59013838008863,5.5228318480997e-06,5.25783817940065,5.21074959149254,1710.75565736304,1.29490403629991e-07,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR1873475","ERR1873475","lineage4.1.2.1","za","South Africa","pnca_p.val139gly","A","H","VAL","VA139","pnca_complex.pdb"
|
|
"V139G","L4","PZA","V","V139",139,"G",1,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",5.113,-0.4,-2.377,4.03008,-4.222,-2.37,84,91,-1.171,9,9,0,0,"helix",0.733333333333333,9.18,0.000646830530401,38.9169126950654,38.9169126367817,38.9145296299157,27.8738145664613,12,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,6,0,17,25,-0.101317122593718,-0.61421188630491,0.146784286016069,-0.719863597612958,-0.620418848167539,0.884210526315789,-0.964579901153213,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","147/150","I:V:A",3.66142892829214,0.0005578275078108,1.06087424525349,3.45133171502081,7.13685172053903,722.165073758294,1.59013838008863,5.5228318480997e-06,5.25783817940065,5.21074959149254,1710.75565736304,1.29490403629991e-07,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR2515293","ERR2515293","lineage4.3.3","za","South Africa","pnca_p.val139gly","A","H","VAL","VA139","pnca_complex.pdb"
|
|
"V139L","L2","PZA","V","V139",139,"L",NA,"Pre-MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",5.113,-0.504,-0.462,-1.24107,-0.518,-0.59,79,85,-1.171,9,9,0,0,"helix",0.733333333333333,9.18,0.0007905706482679,21.8981012658228,21.8980984766686,21.8894347089025,28.1227645329198,-28,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-4,0,-1,-3,-2,0,0,0,-0.127659574468085,-0.11937984496124,-0.238612243328463,-0.0883205456095482,-0.154450261780105,0.831578947368421,-0.964579901153213,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","147/150","I:V:A",3.08639980550335,7.90481988040462e-05,0.781907928411257,3.9472675661117,5.63934469685405,143.700732785851,1.34040645979333,4.86279858821822e-06,5.31311371806022,4.52710002121826,207.736204499878,1.13858693465794e-07,"lineage2","dr_mutations_pyrazinamide","LEU",0,"SRS797221","SRR1723744","lineage2.2.1","cn","China:Jiangsu","pnca_p.val139leu","A","H","VAL","VA139","pnca_complex.pdb"
|
|
"V139L","L2","PZA","V","V139",139,"L",1,"XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",5.113,-0.504,-0.462,-1.24107,-0.518,-0.59,79,85,-1.171,9,9,0,0,"helix",0.733333333333333,9.18,0.0007905706482679,21.8981012658228,21.8980984766686,21.8894347089025,28.1227645329198,-28,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-4,0,-1,-3,-2,0,0,0,-0.127659574468085,-0.11937984496124,-0.238612243328463,-0.0883205456095482,-0.154450261780105,0.831578947368421,-0.964579901153213,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","147/150","I:V:A",3.08639980550335,7.90481988040462e-05,0.781907928411257,3.9472675661117,5.63934469685405,143.700732785851,1.34040645979333,4.86279858821822e-06,5.31311371806022,4.52710002121826,207.736204499878,1.13858693465794e-07,"lineage2","dr_mutations_pyrazinamide","LEU",0,"SAMN10961351","SRR8651583","lineage2.2.1","cn","China:Wenzhou","pnca_p.val139leu","A","H","VAL","VA139","pnca_complex.pdb"
|
|
"V139L","L2","PZA","V","V139",139,"L",1,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",5.113,-0.504,-0.462,-1.24107,-0.518,-0.59,79,85,-1.171,9,9,0,0,"helix",0.733333333333333,9.18,0.0007905706482679,21.8981012658228,21.8980984766686,21.8894347089025,28.1227645329198,-28,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-4,0,-1,-3,-2,0,0,0,-0.127659574468085,-0.11937984496124,-0.238612243328463,-0.0883205456095482,-0.154450261780105,0.831578947368421,-0.964579901153213,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","147/150","I:V:A",3.08639980550335,7.90481988040462e-05,0.781907928411257,3.9472675661117,5.63934469685405,143.700732785851,1.34040645979333,4.86279858821822e-06,5.31311371806022,4.52710002121826,207.736204499878,1.13858693465794e-07,"lineage2","dr_mutations_pyrazinamide","LEU",0,"SAMN10961355","SRR8651596","lineage2.2.1","cn","China:Wenzhou","pnca_p.val139leu","A","H","VAL","VA139","pnca_complex.pdb"
|
|
"V139L","L3","PZA","V","V139",139,"L",1,"MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",5.113,-0.504,-0.462,-1.24107,-0.518,-0.59,79,85,-1.171,9,9,0,0,"helix",0.733333333333333,9.18,0.0007905706482679,21.8981012658228,21.8980984766686,21.8894347089025,28.1227645329198,-28,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-4,0,-1,-3,-2,0,0,0,-0.127659574468085,-0.11937984496124,-0.238612243328463,-0.0883205456095482,-0.154450261780105,0.831578947368421,-0.964579901153213,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","147/150","I:V:A",3.08639980550335,7.90481988040462e-05,0.781907928411257,3.9472675661117,5.63934469685405,143.700732785851,1.34040645979333,4.86279858821822e-06,5.31311371806022,4.52710002121826,207.736204499878,1.13858693465794e-07,"lineage3","dr_mutations_pyrazinamide","LEU",0,"SAMN03647467,SRR2100294","SRR2100294","lineage3","","","pnca_p.val139leu","A","H","VAL","VA139","pnca_complex.pdb"
|
|
"V139L","L2","PZA","V","V139",139,"L",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",5.113,-0.504,-0.462,-1.24107,-0.518,-0.59,79,85,-1.171,9,9,0,0,"helix",0.733333333333333,9.18,0.0007905706482679,21.8981012658228,21.8980984766686,21.8894347089025,28.1227645329198,-28,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-4,0,-1,-3,-2,0,0,0,-0.127659574468085,-0.11937984496124,-0.238612243328463,-0.0883205456095482,-0.154450261780105,0.831578947368421,-0.964579901153213,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","147/150","I:V:A",3.08639980550335,7.90481988040462e-05,0.781907928411257,3.9472675661117,5.63934469685405,143.700732785851,1.34040645979333,4.86279858821822e-06,5.31311371806022,4.52710002121826,207.736204499878,1.13858693465794e-07,"lineage2","dr_mutations_pyrazinamide","LEU",0,"SRS797234","SRR1723758_SRR1723759","lineage2.2.1","cn","China:Fujian","pnca_p.val139leu","A","H","VAL","VA139","pnca_complex.pdb"
|
|
"V139L","L3","PZA","V","V139",139,"L",1,"MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",5.113,-0.504,-0.462,-1.24107,-0.518,-0.59,79,85,-1.171,9,9,0,0,"helix",0.733333333333333,9.18,0.0007905706482679,21.8981012658228,21.8980984766686,21.8894347089025,28.1227645329198,-28,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-4,0,-1,-3,-2,0,0,0,-0.127659574468085,-0.11937984496124,-0.238612243328463,-0.0883205456095482,-0.154450261780105,0.831578947368421,-0.964579901153213,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","147/150","I:V:A",3.08639980550335,7.90481988040462e-05,0.781907928411257,3.9472675661117,5.63934469685405,143.700732785851,1.34040645979333,4.86279858821822e-06,5.31311371806022,4.52710002121826,207.736204499878,1.13858693465794e-07,"lineage3","dr_mutations_pyrazinamide","LEU",0,"ERR2517067","ERR2517067","lineage3","gb","UK","pnca_p.val139leu","A","H","VAL","VA139","pnca_complex.pdb"
|
|
"V139L","L2","PZA","V","V139",139,"L",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",5.113,-0.504,-0.462,-1.24107,-0.518,-0.59,79,85,-1.171,9,9,0,0,"helix",0.733333333333333,9.18,0.0007905706482679,21.8981012658228,21.8980984766686,21.8894347089025,28.1227645329198,-28,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-4,0,-1,-3,-2,0,0,0,-0.127659574468085,-0.11937984496124,-0.238612243328463,-0.0883205456095482,-0.154450261780105,0.831578947368421,-0.964579901153213,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","147/150","I:V:A",3.08639980550335,7.90481988040462e-05,0.781907928411257,3.9472675661117,5.63934469685405,143.700732785851,1.34040645979333,4.86279858821822e-06,5.31311371806022,4.52710002121826,207.736204499878,1.13858693465794e-07,"lineage2","dr_mutations_pyrazinamide","LEU",0,"SRS797235","SRR1723760","lineage2.2.1","cn","China:Fujian","pnca_p.val139leu","A","H","VAL","VA139","pnca_complex.pdb"
|
|
"V139L","L2","PZA","V","V139",139,"L",1,"Pre-MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",5.113,-0.504,-0.462,-1.24107,-0.518,-0.59,79,85,-1.171,9,9,0,0,"helix",0.733333333333333,9.18,0.0007905706482679,21.8981012658228,21.8980984766686,21.8894347089025,28.1227645329198,-28,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-4,0,-1,-3,-2,0,0,0,-0.127659574468085,-0.11937984496124,-0.238612243328463,-0.0883205456095482,-0.154450261780105,0.831578947368421,-0.964579901153213,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","147/150","I:V:A",3.08639980550335,7.90481988040462e-05,0.781907928411257,3.9472675661117,5.63934469685405,143.700732785851,1.34040645979333,4.86279858821822e-06,5.31311371806022,4.52710002121826,207.736204499878,1.13858693465794e-07,"lineage2","dr_mutations_pyrazinamide","LEU",0,"MDR_10443","SRR6824680","lineage2.2.1","cn","China: Pei County, Xuzhou City, Jiangsu Province","pnca_p.val139leu","A","H","VAL","VA139","pnca_complex.pdb"
|
|
"V139L","L2","PZA","V","V139",139,"L",1,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",5.113,-0.504,-0.462,-1.24107,-0.518,-0.59,79,85,-1.171,9,9,0,0,"helix",0.733333333333333,9.18,0.0007905706482679,21.8981012658228,21.8980984766686,21.8894347089025,28.1227645329198,-28,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-4,0,-1,-3,-2,0,0,0,-0.127659574468085,-0.11937984496124,-0.238612243328463,-0.0883205456095482,-0.154450261780105,0.831578947368421,-0.964579901153213,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","147/150","I:V:A",3.08639980550335,7.90481988040462e-05,0.781907928411257,3.9472675661117,5.63934469685405,143.700732785851,1.34040645979333,4.86279858821822e-06,5.31311371806022,4.52710002121826,207.736204499878,1.13858693465794e-07,"lineage2","dr_mutations_pyrazinamide","LEU",0,"ERS458025","ERR552399_ERR552398","lineage2.2.1","uz","Nukus","pnca_p.val139leu","A","H","VAL","VA139","pnca_complex.pdb"
|
|
"V139L","L4","PZA","V","V139",139,"L",0,"MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",5.113,-0.504,-0.462,-1.24107,-0.518,-0.59,79,85,-1.171,9,9,0,0,"helix",0.733333333333333,9.18,0.0007905706482679,21.8981012658228,21.8980984766686,21.8894347089025,28.1227645329198,-28,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-4,0,-1,-3,-2,0,0,0,-0.127659574468085,-0.11937984496124,-0.238612243328463,-0.0883205456095482,-0.154450261780105,0.831578947368421,-0.964579901153213,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","147/150","I:V:A",3.08639980550335,7.90481988040462e-05,0.781907928411257,3.9472675661117,5.63934469685405,143.700732785851,1.34040645979333,4.86279858821822e-06,5.31311371806022,4.52710002121826,207.736204499878,1.13858693465794e-07,"lineage4","dr_mutations_pyrazinamide","LEU",0,"MDR_11166","SRR6824331","lineage4.4.2","cn","China: Luqiao District, Taizhou City, Zhejiang Province","pnca_p.val139leu","A","H","VAL","VA139","pnca_complex.pdb"
|
|
"V139L","L4","PZA","V","V139",139,"L",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",5.113,-0.504,-0.462,-1.24107,-0.518,-0.59,79,85,-1.171,9,9,0,0,"helix",0.733333333333333,9.18,0.0007905706482679,21.8981012658228,21.8980984766686,21.8894347089025,28.1227645329198,-28,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-4,0,-1,-3,-2,0,0,0,-0.127659574468085,-0.11937984496124,-0.238612243328463,-0.0883205456095482,-0.154450261780105,0.831578947368421,-0.964579901153213,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","147/150","I:V:A",3.08639980550335,7.90481988040462e-05,0.781907928411257,3.9472675661117,5.63934469685405,143.700732785851,1.34040645979333,4.86279858821822e-06,5.31311371806022,4.52710002121826,207.736204499878,1.13858693465794e-07,"lineage4","dr_mutations_pyrazinamide","LEU",0,"ERR2179653","ERR2179653","lineage4.4.2","cn","China","pnca_p.val139leu","A","H","VAL","VA139","pnca_complex.pdb"
|
|
"V139L","L3","PZA","V","V139",139,"L",0,"MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",5.113,-0.504,-0.462,-1.24107,-0.518,-0.59,79,85,-1.171,9,9,0,0,"helix",0.733333333333333,9.18,0.0007905706482679,21.8981012658228,21.8980984766686,21.8894347089025,28.1227645329198,-28,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-4,0,-1,-3,-2,0,0,0,-0.127659574468085,-0.11937984496124,-0.238612243328463,-0.0883205456095482,-0.154450261780105,0.831578947368421,-0.964579901153213,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","147/150","I:V:A",3.08639980550335,7.90481988040462e-05,0.781907928411257,3.9472675661117,5.63934469685405,143.700732785851,1.34040645979333,4.86279858821822e-06,5.31311371806022,4.52710002121826,207.736204499878,1.13858693465794e-07,"lineage3","dr_mutations_pyrazinamide","LEU",0,"ERR2512821","ERR2512821","lineage3","gb","UK","pnca_p.val139leu","A","H","VAL","VA139","pnca_complex.pdb"
|
|
"V139L","L4","PZA","V","V139",139,"L",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",5.113,-0.504,-0.462,-1.24107,-0.518,-0.59,79,85,-1.171,9,9,0,0,"helix",0.733333333333333,9.18,0.0007905706482679,21.8981012658228,21.8980984766686,21.8894347089025,28.1227645329198,-28,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-4,0,-1,-3,-2,0,0,0,-0.127659574468085,-0.11937984496124,-0.238612243328463,-0.0883205456095482,-0.154450261780105,0.831578947368421,-0.964579901153213,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","147/150","I:V:A",3.08639980550335,7.90481988040462e-05,0.781907928411257,3.9472675661117,5.63934469685405,143.700732785851,1.34040645979333,4.86279858821822e-06,5.31311371806022,4.52710002121826,207.736204499878,1.13858693465794e-07,"lineage4","dr_mutations_pyrazinamide","LEU",0,"SRS797453","SRR1723993","lineage4.4.2","cn","China:Zhejiang","pnca_p.val139leu","A","H","VAL","VA139","pnca_complex.pdb"
|
|
"V139L","L4","PZA","V","V139",139,"L",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",5.113,-0.504,-0.462,-1.24107,-0.518,-0.59,79,85,-1.171,9,9,0,0,"helix",0.733333333333333,9.18,0.0007905706482679,21.8981012658228,21.8980984766686,21.8894347089025,28.1227645329198,-28,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-4,0,-1,-3,-2,0,0,0,-0.127659574468085,-0.11937984496124,-0.238612243328463,-0.0883205456095482,-0.154450261780105,0.831578947368421,-0.964579901153213,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","147/150","I:V:A",3.08639980550335,7.90481988040462e-05,0.781907928411257,3.9472675661117,5.63934469685405,143.700732785851,1.34040645979333,4.86279858821822e-06,5.31311371806022,4.52710002121826,207.736204499878,1.13858693465794e-07,"lineage4","dr_mutations_pyrazinamide","LEU",0,"ERR2516679","ERR2516679","lineage4.3.4.1","nl","Netherlands","pnca_p.val139leu","A","H","VAL","VA139","pnca_complex.pdb"
|
|
"V139L","L2","PZA","V","V139",139,"L",1,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",5.113,-0.504,-0.462,-1.24107,-0.518,-0.59,79,85,-1.171,9,9,0,0,"helix",0.733333333333333,9.18,0.0007905706482679,21.8981012658228,21.8980984766686,21.8894347089025,28.1227645329198,-28,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-4,0,-1,-3,-2,0,0,0,-0.127659574468085,-0.11937984496124,-0.238612243328463,-0.0883205456095482,-0.154450261780105,0.831578947368421,-0.964579901153213,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","147/150","I:V:A",3.08639980550335,7.90481988040462e-05,0.781907928411257,3.9472675661117,5.63934469685405,143.700732785851,1.34040645979333,4.86279858821822e-06,5.31311371806022,4.52710002121826,207.736204499878,1.13858693465794e-07,"lineage2","dr_mutations_pyrazinamide","LEU",0,"MDR_13165","SRR6824675","lineage2.2.1","cn","China: Changting County, Longyan City, Fujian Province","pnca_p.val139leu","A","H","VAL","VA139","pnca_complex.pdb"
|
|
"V139L","L2","PZA","V","V139",139,"L",1,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",5.113,-0.504,-0.462,-1.24107,-0.518,-0.59,79,85,-1.171,9,9,0,0,"helix",0.733333333333333,9.18,0.0007905706482679,21.8981012658228,21.8980984766686,21.8894347089025,28.1227645329198,-28,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-4,0,-1,-3,-2,0,0,0,-0.127659574468085,-0.11937984496124,-0.238612243328463,-0.0883205456095482,-0.154450261780105,0.831578947368421,-0.964579901153213,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","147/150","I:V:A",3.08639980550335,7.90481988040462e-05,0.781907928411257,3.9472675661117,5.63934469685405,143.700732785851,1.34040645979333,4.86279858821822e-06,5.31311371806022,4.52710002121826,207.736204499878,1.13858693465794e-07,"lineage2","dr_mutations_pyrazinamide","LEU",0,"ERR2517087","ERR2517087","lineage2.2.1","gb","UK","pnca_p.val139leu","A","H","VAL","VA139","pnca_complex.pdb"
|
|
"V139L","L2","PZA","V","V139",139,"L",1,"MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",5.113,-0.504,-0.462,-1.24107,-0.518,-0.59,79,85,-1.171,9,9,0,0,"helix",0.733333333333333,9.18,0.0007905706482679,21.8981012658228,21.8980984766686,21.8894347089025,28.1227645329198,-28,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-4,0,-1,-3,-2,0,0,0,-0.127659574468085,-0.11937984496124,-0.238612243328463,-0.0883205456095482,-0.154450261780105,0.831578947368421,-0.964579901153213,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","147/150","I:V:A",3.08639980550335,7.90481988040462e-05,0.781907928411257,3.9472675661117,5.63934469685405,143.700732785851,1.34040645979333,4.86279858821822e-06,5.31311371806022,4.52710002121826,207.736204499878,1.13858693465794e-07,"lineage2","dr_mutations_pyrazinamide","LEU",0,"MDR_13137","SRR6824631","lineage2.2.1","cn","China: Changting County, Longyan City, Fujian Province","pnca_p.val139leu","A","H","VAL","VA139","pnca_complex.pdb"
|
|
"V139M","L4","PZA","V","V139",139,"M",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",5.113,-1.067,-0.944,-0.87501,-1.235,-1,69,80,-1.171,9,9,0,0,"helix",0.733333333333333,9.18,0.000646830530401,38.9169126950654,38.9169126367816,38.9145296299157,27.8738145664613,-44,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-6,0,-1,-5,-2,0,0,0,-0.270263424518744,-0.243927648578811,-0.168232331000538,-0.210571184995737,-0.261780104712042,0.726315789473684,-0.964579901153213,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","147/150","I:V:A",3.66142892829214,0.0005578275078108,1.06087424525349,3.4513317150208,7.13685172054607,722.165073756559,1.59013838008863,5.5228318480997e-06,5.25783817940065,5.21074959149254,1710.75565736304,1.29490403629991e-07,"lineage4","dr_mutations_pyrazinamide","MET",0,"ERR1034990","ERR1034990","lineage4.1.1.3","za","South Africa","pnca_p.val139met","A","H","VAL","VA139","pnca_complex.pdb"
|
|
"V139M","L4","PZA","V","V139",139,"M",1,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",5.113,-1.067,-0.944,-0.87501,-1.235,-1,69,80,-1.171,9,9,0,0,"helix",0.733333333333333,9.18,0.000646830530401,38.9169126950654,38.9169126367816,38.9145296299157,27.8738145664613,-44,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-6,0,-1,-5,-2,0,0,0,-0.270263424518744,-0.243927648578811,-0.168232331000538,-0.210571184995737,-0.261780104712042,0.726315789473684,-0.964579901153213,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","147/150","I:V:A",3.66142892829214,0.0005578275078108,1.06087424525349,3.4513317150208,7.13685172054607,722.165073756559,1.59013838008863,5.5228318480997e-06,5.25783817940065,5.21074959149254,1710.75565736304,1.29490403629991e-07,"lineage4","dr_mutations_pyrazinamide","MET",0,"ERR1873546","ERR1873546","lineage4.1.1.3","za","South Africa","pnca_p.val139met","A","H","VAL","VA139","pnca_complex.pdb"
|
|
"V139M","L4","PZA","V","V139",139,"M",1,"XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",5.113,-1.067,-0.944,-0.87501,-1.235,-1,69,80,-1.171,9,9,0,0,"helix",0.733333333333333,9.18,0.000646830530401,38.9169126950654,38.9169126367816,38.9145296299157,27.8738145664613,-44,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-6,0,-1,-5,-2,0,0,0,-0.270263424518744,-0.243927648578811,-0.168232331000538,-0.210571184995737,-0.261780104712042,0.726315789473684,-0.964579901153213,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","147/150","I:V:A",3.66142892829214,0.0005578275078108,1.06087424525349,3.4513317150208,7.13685172054607,722.165073756559,1.59013838008863,5.5228318480997e-06,5.25783817940065,5.21074959149254,1710.75565736304,1.29490403629991e-07,"lineage4","dr_mutations_pyrazinamide","MET",0,"ERR1873540","ERR1873540","lineage4.1.1.3","za","South Africa","pnca_p.val139met","A","H","VAL","VA139","pnca_complex.pdb"
|
|
"V139M","L3","PZA","V","V139",139,"M",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",5.113,-1.067,-0.944,-0.87501,-1.235,-1,69,80,-1.171,9,9,0,0,"helix",0.733333333333333,9.18,0.000646830530401,38.9169126950654,38.9169126367816,38.9145296299157,27.8738145664613,-44,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-6,0,-1,-5,-2,0,0,0,-0.270263424518744,-0.243927648578811,-0.168232331000538,-0.210571184995737,-0.261780104712042,0.726315789473684,-0.964579901153213,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","147/150","I:V:A",3.66142892829214,0.0005578275078108,1.06087424525349,3.4513317150208,7.13685172054607,722.165073756559,1.59013838008863,5.5228318480997e-06,5.25783817940065,5.21074959149254,1710.75565736304,1.29490403629991e-07,"lineage3","dr_mutations_pyrazinamide","MET",0,"SRR5818602","SRR5818602","lineage3","dj","Djibouti","pnca_p.val139met","A","H","VAL","VA139","pnca_complex.pdb"
|
|
"V139M","L4","PZA","V","V139",139,"M",NA,"XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",5.113,-1.067,-0.944,-0.87501,-1.235,-1,69,80,-1.171,9,9,0,0,"helix",0.733333333333333,9.18,0.000646830530401,38.9169126950654,38.9169126367816,38.9145296299157,27.8738145664613,-44,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-6,0,-1,-5,-2,0,0,0,-0.270263424518744,-0.243927648578811,-0.168232331000538,-0.210571184995737,-0.261780104712042,0.726315789473684,-0.964579901153213,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","147/150","I:V:A",3.66142892829214,0.0005578275078108,1.06087424525349,3.4513317150208,7.13685172054607,722.165073756559,1.59013838008863,5.5228318480997e-06,5.25783817940065,5.21074959149254,1710.75565736304,1.29490403629991e-07,"lineage4","dr_mutations_pyrazinamide","MET",0,"ERR2515568","ERR2515568","lineage4.1.1.3","za","South Africa","pnca_p.val139met","A","H","VAL","VA139","pnca_complex.pdb"
|
|
"V139M","L4","PZA","V","V139",139,"M",1,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",5.113,-1.067,-0.944,-0.87501,-1.235,-1,69,80,-1.171,9,9,0,0,"helix",0.733333333333333,9.18,0.000646830530401,38.9169126950654,38.9169126367816,38.9145296299157,27.8738145664613,-44,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-6,0,-1,-5,-2,0,0,0,-0.270263424518744,-0.243927648578811,-0.168232331000538,-0.210571184995737,-0.261780104712042,0.726315789473684,-0.964579901153213,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","147/150","I:V:A",3.66142892829214,0.0005578275078108,1.06087424525349,3.4513317150208,7.13685172054607,722.165073756559,1.59013838008863,5.5228318480997e-06,5.25783817940065,5.21074959149254,1710.75565736304,1.29490403629991e-07,"lineage4","dr_mutations_pyrazinamide","MET",0,"ERR1873441","ERR1873441","lineage4.1.1.3","za","South Africa","pnca_p.val139met","A","H","VAL","VA139","pnca_complex.pdb"
|
|
"V139M","L1","PZA","V","V139",139,"M",1,"MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",5.113,-1.067,-0.944,-0.87501,-1.235,-1,69,80,-1.171,9,9,0,0,"helix",0.733333333333333,9.18,0.000646830530401,38.9169126950654,38.9169126367816,38.9145296299157,27.8738145664613,-44,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-6,0,-1,-5,-2,0,0,0,-0.270263424518744,-0.243927648578811,-0.168232331000538,-0.210571184995737,-0.261780104712042,0.726315789473684,-0.964579901153213,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","147/150","I:V:A",3.66142892829214,0.0005578275078108,1.06087424525349,3.4513317150208,7.13685172054607,722.165073756559,1.59013838008863,5.5228318480997e-06,5.25783817940065,5.21074959149254,1710.75565736304,1.29490403629991e-07,"lineage1","dr_mutations_pyrazinamide","MET",0,"ERS2286333","ERR2503407","lineage1.2.1","fi","Finland","pnca_p.val139met","A","H","VAL","VA139","pnca_complex.pdb"
|
|
"V139M","L4","PZA","V","V139",139,"M",1,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",5.113,-1.067,-0.944,-0.87501,-1.235,-1,69,80,-1.171,9,9,0,0,"helix",0.733333333333333,9.18,0.000646830530401,38.9169126950654,38.9169126367816,38.9145296299157,27.8738145664613,-44,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-6,0,-1,-5,-2,0,0,0,-0.270263424518744,-0.243927648578811,-0.168232331000538,-0.210571184995737,-0.261780104712042,0.726315789473684,-0.964579901153213,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","147/150","I:V:A",3.66142892829214,0.0005578275078108,1.06087424525349,3.4513317150208,7.13685172054607,722.165073756559,1.59013838008863,5.5228318480997e-06,5.25783817940065,5.21074959149254,1710.75565736304,1.29490403629991e-07,"lineage4","dr_mutations_pyrazinamide","MET",0,"ERR1873448","ERR1873448","lineage4.1.1.3","za","South Africa","pnca_p.val139met","A","H","VAL","VA139","pnca_complex.pdb"
|
|
"V139M","L4","PZA","V","V139",139,"M",NA,"XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",5.113,-1.067,-0.944,-0.87501,-1.235,-1,69,80,-1.171,9,9,0,0,"helix",0.733333333333333,9.18,0.000646830530401,38.9169126950654,38.9169126367816,38.9145296299157,27.8738145664613,-44,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-6,0,-1,-5,-2,0,0,0,-0.270263424518744,-0.243927648578811,-0.168232331000538,-0.210571184995737,-0.261780104712042,0.726315789473684,-0.964579901153213,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","147/150","I:V:A",3.66142892829214,0.0005578275078108,1.06087424525349,3.4513317150208,7.13685172054607,722.165073756559,1.59013838008863,5.5228318480997e-06,5.25783817940065,5.21074959149254,1710.75565736304,1.29490403629991e-07,"lineage4","dr_mutations_pyrazinamide","MET",0,"ERR2515133","ERR2515133","lineage4.1.1.3","za","South Africa","pnca_p.val139met","A","H","VAL","VA139","pnca_complex.pdb"
|
|
"V139M","L4","PZA","V","V139",139,"M",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",5.113,-1.067,-0.944,-0.87501,-1.235,-1,69,80,-1.171,9,9,0,0,"helix",0.733333333333333,9.18,0.000646830530401,38.9169126950654,38.9169126367816,38.9145296299157,27.8738145664613,-44,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-6,0,-1,-5,-2,0,0,0,-0.270263424518744,-0.243927648578811,-0.168232331000538,-0.210571184995737,-0.261780104712042,0.726315789473684,-0.964579901153213,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","147/150","I:V:A",3.66142892829214,0.0005578275078108,1.06087424525349,3.4513317150208,7.13685172054607,722.165073756559,1.59013838008863,5.5228318480997e-06,5.25783817940065,5.21074959149254,1710.75565736304,1.29490403629991e-07,"lineage4","dr_mutations_pyrazinamide","MET",0,"ERR2515475","ERR2515475","lineage4.1.1.3","za","South Africa","pnca_p.val139met","A","H","VAL","VA139","pnca_complex.pdb"
|
|
"V139M","L4","PZA","V","V139",139,"M",1,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",5.113,-1.067,-0.944,-0.87501,-1.235,-1,69,80,-1.171,9,9,0,0,"helix",0.733333333333333,9.18,0.000646830530401,38.9169126950654,38.9169126367816,38.9145296299157,27.8738145664613,-44,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-6,0,-1,-5,-2,0,0,0,-0.270263424518744,-0.243927648578811,-0.168232331000538,-0.210571184995737,-0.261780104712042,0.726315789473684,-0.964579901153213,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","147/150","I:V:A",3.66142892829214,0.0005578275078108,1.06087424525349,3.4513317150208,7.13685172054607,722.165073756559,1.59013838008863,5.5228318480997e-06,5.25783817940065,5.21074959149254,1710.75565736304,1.29490403629991e-07,"lineage4","dr_mutations_pyrazinamide","MET",0,"ERR1873446","ERR1873446","lineage4.1.1.3","za","South Africa","pnca_p.val139met","A","H","VAL","VA139","pnca_complex.pdb"
|
|
"V139M","L4","PZA","V","V139",139,"M",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",5.113,-1.067,-0.944,-0.87501,-1.235,-1,69,80,-1.171,9,9,0,0,"helix",0.733333333333333,9.18,0.000646830530401,38.9169126950654,38.9169126367816,38.9145296299157,27.8738145664613,-44,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-6,0,-1,-5,-2,0,0,0,-0.270263424518744,-0.243927648578811,-0.168232331000538,-0.210571184995737,-0.261780104712042,0.726315789473684,-0.964579901153213,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","147/150","I:V:A",3.66142892829214,0.0005578275078108,1.06087424525349,3.4513317150208,7.13685172054607,722.165073756559,1.59013838008863,5.5228318480997e-06,5.25783817940065,5.21074959149254,1710.75565736304,1.29490403629991e-07,"lineage4","dr_mutations_pyrazinamide","MET",0,"ERR2515546","ERR2515546","lineage4.1.1.3","za","South Africa","pnca_p.val139met","A","H","VAL","VA139","pnca_complex.pdb"
|
|
"V139M","L4","PZA","V","V139",139,"M",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",5.113,-1.067,-0.944,-0.87501,-1.235,-1,69,80,-1.171,9,9,0,0,"helix",0.733333333333333,9.18,0.000646830530401,38.9169126950654,38.9169126367816,38.9145296299157,27.8738145664613,-44,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-6,0,-1,-5,-2,0,0,0,-0.270263424518744,-0.243927648578811,-0.168232331000538,-0.210571184995737,-0.261780104712042,0.726315789473684,-0.964579901153213,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","147/150","I:V:A",3.66142892829214,0.0005578275078108,1.06087424525349,3.4513317150208,7.13685172054607,722.165073756559,1.59013838008863,5.5228318480997e-06,5.25783817940065,5.21074959149254,1710.75565736304,1.29490403629991e-07,"lineage4","dr_mutations_pyrazinamide","MET",0,"ERR1035037","ERR1035037","lineage4.1.1.3","za","South Africa","pnca_p.val139met","A","H","VAL","VA139","pnca_complex.pdb"
|
|
"V139M","L4","PZA","V","V139",139,"M",1,"XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",5.113,-1.067,-0.944,-0.87501,-1.235,-1,69,80,-1.171,9,9,0,0,"helix",0.733333333333333,9.18,0.000646830530401,38.9169126950654,38.9169126367816,38.9145296299157,27.8738145664613,-44,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-6,0,-1,-5,-2,0,0,0,-0.270263424518744,-0.243927648578811,-0.168232331000538,-0.210571184995737,-0.261780104712042,0.726315789473684,-0.964579901153213,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","147/150","I:V:A",3.66142892829214,0.0005578275078108,1.06087424525349,3.4513317150208,7.13685172054607,722.165073756559,1.59013838008863,5.5228318480997e-06,5.25783817940065,5.21074959149254,1710.75565736304,1.29490403629991e-07,"lineage4","dr_mutations_pyrazinamide","MET",0,"ERR1873554","ERR1873554","lineage4.1.1.3","za","South Africa","pnca_p.val139met","A","H","VAL","VA139","pnca_complex.pdb"
|
|
"V139M","L4","PZA","V","V139",139,"M",0,"XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",5.113,-1.067,-0.944,-0.87501,-1.235,-1,69,80,-1.171,9,9,0,0,"helix",0.733333333333333,9.18,0.000646830530401,38.9169126950654,38.9169126367816,38.9145296299157,27.8738145664613,-44,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-6,0,-1,-5,-2,0,0,0,-0.270263424518744,-0.243927648578811,-0.168232331000538,-0.210571184995737,-0.261780104712042,0.726315789473684,-0.964579901153213,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","147/150","I:V:A",3.66142892829214,0.0005578275078108,1.06087424525349,3.4513317150208,7.13685172054607,722.165073756559,1.59013838008863,5.5228318480997e-06,5.25783817940065,5.21074959149254,1710.75565736304,1.29490403629991e-07,"lineage4","dr_mutations_pyrazinamide","MET",0,"ERR1873550","ERR1873550","lineage4.1.1.3","za","South Africa","pnca_p.val139met","A","H","VAL","VA139","pnca_complex.pdb"
|
|
"V139M","L4","PZA","V","V139",139,"M",1,"XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",5.113,-1.067,-0.944,-0.87501,-1.235,-1,69,80,-1.171,9,9,0,0,"helix",0.733333333333333,9.18,0.000646830530401,38.9169126950654,38.9169126367816,38.9145296299157,27.8738145664613,-44,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-6,0,-1,-5,-2,0,0,0,-0.270263424518744,-0.243927648578811,-0.168232331000538,-0.210571184995737,-0.261780104712042,0.726315789473684,-0.964579901153213,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","147/150","I:V:A",3.66142892829214,0.0005578275078108,1.06087424525349,3.4513317150208,7.13685172054607,722.165073756559,1.59013838008863,5.5228318480997e-06,5.25783817940065,5.21074959149254,1710.75565736304,1.29490403629991e-07,"lineage4","dr_mutations_pyrazinamide","MET",0,"ERR1873462","ERR1873462","lineage4.1.1.3","za","South Africa","pnca_p.val139met","A","H","VAL","VA139","pnca_complex.pdb"
|
|
"V139M","L4","PZA","V","V139",139,"M",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",5.113,-1.067,-0.944,-0.87501,-1.235,-1,69,80,-1.171,9,9,0,0,"helix",0.733333333333333,9.18,0.000646830530401,38.9169126950654,38.9169126367816,38.9145296299157,27.8738145664613,-44,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-6,0,-1,-5,-2,0,0,0,-0.270263424518744,-0.243927648578811,-0.168232331000538,-0.210571184995737,-0.261780104712042,0.726315789473684,-0.964579901153213,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.221,-1.152,"9:9","147/150","I:V:A",3.66142892829214,0.0005578275078108,1.06087424525349,3.4513317150208,7.13685172054607,722.165073756559,1.59013838008863,5.5228318480997e-06,5.25783817940065,5.21074959149254,1710.75565736304,1.29490403629991e-07,"lineage4","dr_mutations_pyrazinamide","MET",0,"ERR1035061","ERR1035061","lineage4.1.1.3","za","South Africa","pnca_p.val139met","A","H","VAL","VA139","pnca_complex.pdb"
|
|
"R140G","L3","PZA","R","R140",140,"G",NA,"Pre-XDR","DM","hydrophilic","hydrophobic","basic","neutral","pos","non-polar",7.347,-1.735,-1.398,5.02413,-1.666,-1.21,71,85,-0.185,6,6,58,0.211678832116788,"helix",-1.26666666666667,5.39,NA,NA,NA,NA,NA,70,36,0,0,36,0,0,0,0,4,0,2,4,0,0,0,0,1,0,0,1,6,0,15,17,-0.439463019250253,-0.361240310077519,0.182989750799467,-0.284057971014493,-0.316753926701571,0.747368421052632,-0.152388797364086,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.411,-0.038,"7:5","147/150","G:A:T:N:L:V:K:R:E:Y:H:F:Q",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage3","dr_mutations_pyrazinamide","GLY",0,"ERR3335728","ERR3335728","lineage3","pk","Pakistan","pnca_p.arg140gly","A","H","ARG","RA140","pnca_complex.pdb"
|
|
"R140G","L3","PZA","R","R140",140,"G",NA,"Pre-XDR","DM","hydrophilic","hydrophobic","basic","neutral","pos","non-polar",7.347,-1.735,-1.398,5.02413,-1.666,-1.21,71,85,-0.185,6,6,58,0.211678832116788,"helix",-1.26666666666667,5.39,NA,NA,NA,NA,NA,70,36,0,0,36,0,0,0,0,4,0,2,4,0,0,0,0,1,0,0,1,6,0,15,17,-0.439463019250253,-0.361240310077519,0.182989750799467,-0.284057971014493,-0.316753926701571,0.747368421052632,-0.152388797364086,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.411,-0.038,"7:5","147/150","G:A:T:N:L:V:K:R:E:Y:H:F:Q",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage3","dr_mutations_pyrazinamide","GLY",0,"ERR3335726","ERR3335726","lineage3","pk","Pakistan","pnca_p.arg140gly","A","H","ARG","RA140","pnca_complex.pdb"
|
|
"R140H","L4","PZA","R","R140",140,"H",NA,"MDR","DM","hydrophilic","hydrophobic","basic","basic","pos","pos",7.347,-1.013,-1.041,2.29767,-1.276,-1.42,53,75,-0.185,6,6,58,0.211678832116788,"helix",-1.26666666666667,5.39,NA,NA,NA,NA,NA,38,6,0,0,6,0,0,0,0,2,0,0,2,0,0,0,0,-4,0,-4,-4,-2,0,-2,4,-0.256585612968592,-0.268992248062015,0.0836861428186394,-0.217561807331628,-0.371727748691099,0.557894736842105,-0.152388797364086,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.411,-0.038,"7:5","147/150","G:A:T:N:L:V:K:R:E:Y:H:F:Q",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage4","dr_mutations_pyrazinamide","HIS",0,"2591","ERR2432995","lineage4.3.3","br","Brazil","pnca_p.arg140his","A","H","ARG","RA140","pnca_complex.pdb"
|
|
"R140P","L4","PZA","R","R140",140,"P",NA,"MDR","DM","hydrophilic","hydrophilic","basic","non-polar","pos","non-polar",7.347,-1.466,-0.818,6.54201,-1.939,-0.18,86,91,-0.185,6,6,58,0.211678832116788,"helix",-1.26666666666667,5.39,0.0002156101768003,29.1287878787879,511969.848429156,Inf,9.2872640727157,66,36,0,0,36,0,0,0,0,6,2,2,4,0,0,0,0,-3,2,-8,-1,6,0,6,-2,-0.371327254305978,-0.211369509043928,0.238274244421944,-0.330605285592498,-0.0471204188481675,0.905263157894737,-0.152388797364086,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.411,-0.038,"7:5","147/150","G:A:T:N:L:V:K:R:E:Y:H:F:Q",13.1460210125008,0.90796911154963,113.719344731969,0.115600569485212,0.183926936276834,NA,1.4643224129316,0.0049931328456149,2.3016268790981,2.00455510251839,Inf,0.0023075254069185,"lineage4","dr_mutations_pyrazinamide","PRO",0,"SAMN01925686","SRR924238_SRR847784","lineage4.3.3","za","South Africa","pnca_p.arg140pro","A","H","ARG","RA140","pnca_complex.pdb"
|
|
"R140P","L2","PZA","R","R140",140,"P",1,"Other","DM","hydrophilic","hydrophilic","basic","non-polar","pos","non-polar",7.347,-1.466,-0.818,6.54201,-1.939,-0.18,86,91,-0.185,6,6,58,0.211678832116788,"helix",-1.26666666666667,5.39,0.0002156101768003,29.1287878787879,511969.848429156,Inf,9.2872640727157,66,36,0,0,36,0,0,0,0,6,2,2,4,0,0,0,0,-3,2,-8,-1,6,0,6,-2,-0.371327254305978,-0.211369509043928,0.238274244421944,-0.330605285592498,-0.0471204188481675,0.905263157894737,-0.152388797364086,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.411,-0.038,"7:5","147/150","G:A:T:N:L:V:K:R:E:Y:H:F:Q",13.1460210125008,0.90796911154963,113.719344731969,0.115600569485212,0.183926936276834,NA,1.4643224129316,0.0049931328456149,2.3016268790981,2.00455510251839,Inf,0.0023075254069185,"lineage2","dr_mutations_pyrazinamide","PRO",0,"ERR2515662","ERR2515662","lineage2.2.1","za","South Africa","pnca_p.arg140pro","A","H","ARG","RA140","pnca_complex.pdb"
|
|
"R140P","L2","PZA","R","R140",140,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","basic","non-polar","pos","non-polar",7.347,-1.466,-0.818,6.54201,-1.939,-0.18,86,91,-0.185,6,6,58,0.211678832116788,"helix",-1.26666666666667,5.39,0.0002156101768003,29.1287878787879,511969.848429156,Inf,9.2872640727157,66,36,0,0,36,0,0,0,0,6,2,2,4,0,0,0,0,-3,2,-8,-1,6,0,6,-2,-0.371327254305978,-0.211369509043928,0.238274244421944,-0.330605285592498,-0.0471204188481675,0.905263157894737,-0.152388797364086,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.411,-0.038,"7:5","147/150","G:A:T:N:L:V:K:R:E:Y:H:F:Q",13.1460210125008,0.90796911154963,113.719344731969,0.115600569485212,0.183926936276834,NA,1.4643224129316,0.0049931328456149,2.3016268790981,2.00455510251839,Inf,0.0023075254069185,"lineage2","dr_mutations_pyrazinamide","PRO",0,"0522T-sc-2012-10-11T13:36:17Z-1494070,ERR234584","ERR234584","lineage2.2.1","ru","Russia,Samara","pnca_p.arg140pro","A","H","ARG","RA140","pnca_complex.pdb"
|
|
"R140P","L4","PZA","R","R140",140,"P",1,"MDR","DM","hydrophilic","hydrophilic","basic","non-polar","pos","non-polar",7.347,-1.466,-0.818,6.54201,-1.939,-0.18,86,91,-0.185,6,6,58,0.211678832116788,"helix",-1.26666666666667,5.39,0.0002156101768003,29.1287878787879,511969.848429156,Inf,9.2872640727157,66,36,0,0,36,0,0,0,0,6,2,2,4,0,0,0,0,-3,2,-8,-1,6,0,6,-2,-0.371327254305978,-0.211369509043928,0.238274244421944,-0.330605285592498,-0.0471204188481675,0.905263157894737,-0.152388797364086,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.411,-0.038,"7:5","147/150","G:A:T:N:L:V:K:R:E:Y:H:F:Q",13.1460210125008,0.90796911154963,113.719344731969,0.115600569485212,0.183926936276834,NA,1.4643224129316,0.0049931328456149,2.3016268790981,2.00455510251839,Inf,0.0023075254069185,"lineage4","dr_mutations_pyrazinamide","PRO",0,"SAMN02350441","SRR1062855_SRR1011484","lineage4.3.3","za","South Africa","pnca_p.arg140pro","A","H","ARG","RA140","pnca_complex.pdb"
|
|
"R140S","L4","PZA","R","R140",140,"S",NA,"MDR","DM","hydrophilic","hydrophilic","basic","neutral","pos","polar",7.347,-1.646,-1.705,4.37186,-0.933,-1.49,53,75,-0.185,6,6,58,0.211678832116788,"helix",-1.26666666666667,5.39,7.18700589334483e-05,2.42412778478352,0.0001249735077034,0,1.03410070803344e-29,64,36,0,0,36,0,0,0,0,2,0,0,4,0,0,0,0,1,0,-3,2,6,0,6,6,-0.416919959473151,-0.440568475452196,0.159232657580548,-0.159079283887468,-0.390052356020942,0.557894736842105,-0.152388797364086,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.411,-0.038,"7:5","147/150","G:A:T:N:L:V:K:R:E:Y:H:F:Q",-8.98740878149641,0.940032862253634,119.468044435492,-0.0752285585987745,NA,4692673.51081424,0.384555509373631,1,0,0,188.544222231268,0.999999999999997,"lineage4","dr_mutations_pyrazinamide","SER",0,"ERR2707078","ERR2707078","lineage4.3.4.2","cd","Democratic Republic of Congo","pnca_p.arg140ser","A","H","ARG","RA140","pnca_complex.pdb"
|
|
"R140S","L4","PZA","R","R140",140,"S",NA,"MDR","DM","hydrophilic","hydrophilic","basic","neutral","pos","polar",7.347,-1.646,-1.705,4.37186,-0.933,-1.49,53,75,-0.185,6,6,58,0.211678832116788,"helix",-1.26666666666667,5.39,7.18700589334483e-05,2.42412778478352,0.0001249735077034,0,1.03410070803344e-29,64,36,0,0,36,0,0,0,0,2,0,0,4,0,0,0,0,1,0,-3,2,6,0,6,6,-0.416919959473151,-0.440568475452196,0.159232657580548,-0.159079283887468,-0.390052356020942,0.557894736842105,-0.152388797364086,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.411,-0.038,"7:5","147/150","G:A:T:N:L:V:K:R:E:Y:H:F:Q",-8.98740878149641,0.940032862253634,119.468044435492,-0.0752285585987745,NA,4692673.51081424,0.384555509373631,1,0,0,188.544222231268,0.999999999999997,"lineage4","dr_mutations_pyrazinamide","SER",0,"ERR2707004","ERR2707004","lineage4.3.4.2","cd","Democratic Republic of Congo","pnca_p.arg140ser","A","H","ARG","RA140","pnca_complex.pdb"
|
|
"R140S","L5","PZA","R","R140",140,"S",NA,"MDR","DM","hydrophilic","hydrophilic","basic","neutral","pos","polar",7.347,-1.646,-1.705,4.37186,-0.933,-1.49,53,75,-0.185,6,6,58,0.211678832116788,"helix",-1.26666666666667,5.39,7.18700589334483e-05,2.42412778478352,0.0001249735077034,0,1.03410070803344e-29,64,36,0,0,36,0,0,0,0,2,0,0,4,0,0,0,0,1,0,-3,2,6,0,6,6,-0.416919959473151,-0.440568475452196,0.159232657580548,-0.159079283887468,-0.390052356020942,0.557894736842105,-0.152388797364086,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.411,-0.038,"7:5","147/150","G:A:T:N:L:V:K:R:E:Y:H:F:Q",-8.98740878149641,0.940032862253634,119.468044435492,-0.0752285585987745,NA,4692673.51081424,0.384555509373631,1,0,0,188.544222231268,0.999999999999997,"lineage5","dr_mutations_pyrazinamide","SER",0,"ERR2706930","ERR2706930","lineage5","cd","Democratic Republic of Congo","pnca_p.arg140ser","A","H","ARG","RA140","pnca_complex.pdb"
|
|
"R140S","L5","PZA","R","R140",140,"S",NA,"MDR","DM","hydrophilic","hydrophilic","basic","neutral","pos","polar",7.347,-1.646,-1.705,4.37186,-0.933,-1.49,53,75,-0.185,6,6,58,0.211678832116788,"helix",-1.26666666666667,5.39,7.18700589334483e-05,2.42412778478352,0.0001249735077034,0,1.03410070803344e-29,64,36,0,0,36,0,0,0,0,2,0,0,4,0,0,0,0,1,0,-3,2,6,0,6,6,-0.416919959473151,-0.440568475452196,0.159232657580548,-0.159079283887468,-0.390052356020942,0.557894736842105,-0.152388797364086,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.411,-0.038,"7:5","147/150","G:A:T:N:L:V:K:R:E:Y:H:F:Q",-8.98740878149641,0.940032862253634,119.468044435492,-0.0752285585987745,NA,4692673.51081424,0.384555509373631,1,0,0,188.544222231268,0.999999999999997,"lineage5","dr_mutations_pyrazinamide","SER",0,"ERR2706914","ERR2706914","lineage5","cd","Democratic Republic of Congo","pnca_p.arg140ser","A","H","ARG","RA140","pnca_complex.pdb"
|
|
"R140S","L2","PZA","R","R140",140,"S",0,"MDR","DM","hydrophilic","hydrophilic","basic","neutral","pos","polar",7.347,-1.646,-1.705,4.37186,-0.933,-1.49,53,75,-0.185,6,6,58,0.211678832116788,"helix",-1.26666666666667,5.39,7.18700589334483e-05,2.42412778478352,0.0001249735077034,0,1.03410070803344e-29,64,36,0,0,36,0,0,0,0,2,0,0,4,0,0,0,0,1,0,-3,2,6,0,6,6,-0.416919959473151,-0.440568475452196,0.159232657580548,-0.159079283887468,-0.390052356020942,0.557894736842105,-0.152388797364086,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.411,-0.038,"7:5","147/150","G:A:T:N:L:V:K:R:E:Y:H:F:Q",-8.98740878149641,0.940032862253634,119.468044435492,-0.0752285585987745,NA,4692673.51081424,0.384555509373631,1,0,0,188.544222231268,0.999999999999997,"lineage2","dr_mutations_pyrazinamide","SER",0,"non-MDR_28117","SRR6824623","lineage2.2.2","cn","China: Wushan County, Tianshui City, Gansu Province","pnca_p.arg140ser","A","H","ARG","RA140","pnca_complex.pdb"
|
|
"R140S","L4","PZA","R","R140",140,"S",NA,"MDR","DM","hydrophilic","hydrophilic","basic","neutral","pos","polar",7.347,-1.646,-1.705,4.37186,-0.933,-1.49,53,75,-0.185,6,6,58,0.211678832116788,"helix",-1.26666666666667,5.39,7.18700589334483e-05,2.42412778478352,0.0001249735077034,0,1.03410070803344e-29,64,36,0,0,36,0,0,0,0,2,0,0,4,0,0,0,0,1,0,-3,2,6,0,6,6,-0.416919959473151,-0.440568475452196,0.159232657580548,-0.159079283887468,-0.390052356020942,0.557894736842105,-0.152388797364086,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.411,-0.038,"7:5","147/150","G:A:T:N:L:V:K:R:E:Y:H:F:Q",-8.98740878149641,0.940032862253634,119.468044435492,-0.0752285585987745,NA,4692673.51081424,0.384555509373631,1,0,0,188.544222231268,0.999999999999997,"lineage4","dr_mutations_pyrazinamide","SER",0,"ERR2706949","ERR2706949","lineage4.3.4.2","cd","Democratic Republic of Congo","pnca_p.arg140ser","A","H","ARG","RA140","pnca_complex.pdb"
|
|
"Q141P","L2","PZA","Q","Q141",141,"P",1,"MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",8.108,-1.656,0.901,5.02461,-1.835,1.14,79,85,-0.137,6,6,41,0.182222222222222,"helix",-2.9,5.08,0.0019404915912031,28.1422962648557,28.1422937171073,28.1176868093208,83.7298318312042,30,-31,0,0,-31,0,0,0,0,4,2,0,4,0,0,0,0,3,4,-1,-2,-8,0,-10,-6,-0.419452887537994,0.766156462585034,0.1830072334443,-0.312872975277067,0.640449438202247,0.831578947368421,-0.112850082372323,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-0.332,-0.038,"6:5","147/150","N:C:R:F:H:E:Y:Q:W:D:A:S",3.33727355927796,7.45865029764653e-10,0.542113710503027,6.15603976549737,10.8149160259451,96.0464157669383,1.44935953071313,1.80101596312758e-14,13.744482437837,9.60105095933572,112.1508500808,5.67227891121513e-20,"lineage2","dr_mutations_pyrazinamide","PRO",0,"ERR2517000","ERR2517000","lineage2.2.1","gb","UK","pnca_p.gln141pro","A","H","GLN","QA141","pnca_complex.pdb"
|
|
"Q141P","L4","PZA","Q","Q141",141,"P",NA,"MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",8.108,-1.656,0.901,5.02461,-1.835,1.14,79,85,-0.137,6,6,41,0.182222222222222,"helix",-2.9,5.08,0.0019404915912031,28.1422962648557,28.1422937171073,28.1176868093208,83.7298318312042,30,-31,0,0,-31,0,0,0,0,4,2,0,4,0,0,0,0,3,4,-1,-2,-8,0,-10,-6,-0.419452887537994,0.766156462585034,0.1830072334443,-0.312872975277067,0.640449438202247,0.831578947368421,-0.112850082372323,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-0.332,-0.038,"6:5","147/150","N:C:R:F:H:E:Y:Q:W:D:A:S",3.33727355927796,7.45865029764653e-10,0.542113710503027,6.15603976549737,10.8149160259451,96.0464157669383,1.44935953071313,1.80101596312758e-14,13.744482437837,9.60105095933572,112.1508500808,5.67227891121513e-20,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR1035347","ERR1035347","lineage4.7","br","Brazil","pnca_p.gln141pro","A","H","GLN","QA141","pnca_complex.pdb"
|
|
"Q141P","L2","PZA","Q","Q141",141,"P",NA,"Pre-MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",8.108,-1.656,0.901,5.02461,-1.835,1.14,79,85,-0.137,6,6,41,0.182222222222222,"helix",-2.9,5.08,0.0019404915912031,28.1422962648557,28.1422937171073,28.1176868093208,83.7298318312042,30,-31,0,0,-31,0,0,0,0,4,2,0,4,0,0,0,0,3,4,-1,-2,-8,0,-10,-6,-0.419452887537994,0.766156462585034,0.1830072334443,-0.312872975277067,0.640449438202247,0.831578947368421,-0.112850082372323,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-0.332,-0.038,"6:5","147/150","N:C:R:F:H:E:Y:Q:W:D:A:S",3.33727355927796,7.45865029764653e-10,0.542113710503027,6.15603976549737,10.8149160259451,96.0464157669383,1.44935953071313,1.80101596312758e-14,13.744482437837,9.60105095933572,112.1508500808,5.67227891121513e-20,"lineage2","dr_mutations_pyrazinamide","PRO",0,"DRR184675","DRR184675","lineage2.2.1","vn","Vietnam","pnca_p.gln141pro","A","H","GLN","QA141","pnca_complex.pdb"
|
|
"Q141P","L4","PZA","Q","Q141",141,"P",NA,"MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",8.108,-1.656,0.901,5.02461,-1.835,1.14,79,85,-0.137,6,6,41,0.182222222222222,"helix",-2.9,5.08,0.0019404915912031,28.1422962648557,28.1422937171073,28.1176868093208,83.7298318312042,30,-31,0,0,-31,0,0,0,0,4,2,0,4,0,0,0,0,3,4,-1,-2,-8,0,-10,-6,-0.419452887537994,0.766156462585034,0.1830072334443,-0.312872975277067,0.640449438202247,0.831578947368421,-0.112850082372323,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-0.332,-0.038,"6:5","147/150","N:C:R:F:H:E:Y:Q:W:D:A:S",3.33727355927796,7.45865029764653e-10,0.542113710503027,6.15603976549737,10.8149160259451,96.0464157669383,1.44935953071313,1.80101596312758e-14,13.744482437837,9.60105095933572,112.1508500808,5.67227891121513e-20,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR2706990","ERR2706990","lineage4.6.1.2","cd","Democratic Republic of Congo","pnca_p.gln141pro","A","H","GLN","QA141","pnca_complex.pdb"
|
|
"Q141P","L2","PZA","Q","Q141",141,"P",NA,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",8.108,-1.656,0.901,5.02461,-1.835,1.14,79,85,-0.137,6,6,41,0.182222222222222,"helix",-2.9,5.08,0.0019404915912031,28.1422962648557,28.1422937171073,28.1176868093208,83.7298318312042,30,-31,0,0,-31,0,0,0,0,4,2,0,4,0,0,0,0,3,4,-1,-2,-8,0,-10,-6,-0.419452887537994,0.766156462585034,0.1830072334443,-0.312872975277067,0.640449438202247,0.831578947368421,-0.112850082372323,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-0.332,-0.038,"6:5","147/150","N:C:R:F:H:E:Y:Q:W:D:A:S",3.33727355927796,7.45865029764653e-10,0.542113710503027,6.15603976549737,10.8149160259451,96.0464157669383,1.44935953071313,1.80101596312758e-14,13.744482437837,9.60105095933572,112.1508500808,5.67227891121513e-20,"lineage2","dr_mutations_pyrazinamide","PRO",0,"SAMN07236291,SRR5709996","SRR5709996","lineage2.2.1","th","Thailand","pnca_p.gln141pro","A","H","GLN","QA141","pnca_complex.pdb"
|
|
"Q141P","L4","PZA","Q","Q141",141,"P",NA,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",8.108,-1.656,0.901,5.02461,-1.835,1.14,79,85,-0.137,6,6,41,0.182222222222222,"helix",-2.9,5.08,0.0019404915912031,28.1422962648557,28.1422937171073,28.1176868093208,83.7298318312042,30,-31,0,0,-31,0,0,0,0,4,2,0,4,0,0,0,0,3,4,-1,-2,-8,0,-10,-6,-0.419452887537994,0.766156462585034,0.1830072334443,-0.312872975277067,0.640449438202247,0.831578947368421,-0.112850082372323,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-0.332,-0.038,"6:5","147/150","N:C:R:F:H:E:Y:Q:W:D:A:S",3.33727355927796,7.45865029764653e-10,0.542113710503027,6.15603976549737,10.8149160259451,96.0464157669383,1.44935953071313,1.80101596312758e-14,13.744482437837,9.60105095933572,112.1508500808,5.67227891121513e-20,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR2515528","ERR2515528","lineage4.9","za","South Africa","pnca_p.gln141pro","A","H","GLN","QA141","pnca_complex.pdb"
|
|
"Q141P","L4","PZA","Q","Q141",141,"P",NA,"MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",8.108,-1.656,0.901,5.02461,-1.835,1.14,79,85,-0.137,6,6,41,0.182222222222222,"helix",-2.9,5.08,0.0019404915912031,28.1422962648557,28.1422937171073,28.1176868093208,83.7298318312042,30,-31,0,0,-31,0,0,0,0,4,2,0,4,0,0,0,0,3,4,-1,-2,-8,0,-10,-6,-0.419452887537994,0.766156462585034,0.1830072334443,-0.312872975277067,0.640449438202247,0.831578947368421,-0.112850082372323,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-0.332,-0.038,"6:5","147/150","N:C:R:F:H:E:Y:Q:W:D:A:S",3.33727355927796,7.45865029764653e-10,0.542113710503027,6.15603976549737,10.8149160259451,96.0464157669383,1.44935953071313,1.80101596312758e-14,13.744482437837,9.60105095933572,112.1508500808,5.67227891121513e-20,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR2706919","ERR2706919","lineage4.6.1.2","cd","Democratic Republic of Congo","pnca_p.gln141pro","A","H","GLN","QA141","pnca_complex.pdb"
|
|
"Q141P","L4","PZA","Q","Q141",141,"P",0,"MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",8.108,-1.656,0.901,5.02461,-1.835,1.14,79,85,-0.137,6,6,41,0.182222222222222,"helix",-2.9,5.08,0.0019404915912031,28.1422962648557,28.1422937171073,28.1176868093208,83.7298318312042,30,-31,0,0,-31,0,0,0,0,4,2,0,4,0,0,0,0,3,4,-1,-2,-8,0,-10,-6,-0.419452887537994,0.766156462585034,0.1830072334443,-0.312872975277067,0.640449438202247,0.831578947368421,-0.112850082372323,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-0.332,-0.038,"6:5","147/150","N:C:R:F:H:E:Y:Q:W:D:A:S",3.33727355927796,7.45865029764653e-10,0.542113710503027,6.15603976549737,10.8149160259451,96.0464157669383,1.44935953071313,1.80101596312758e-14,13.744482437837,9.60105095933572,112.1508500808,5.67227891121513e-20,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR181861","ERR181861","lineage4.3.4.2.1","mw","Malawi","pnca_p.gln141pro","A","H","GLN","QA141","pnca_complex.pdb"
|
|
"Q141P","L4","PZA","Q","Q141",141,"P",1,"MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",8.108,-1.656,0.901,5.02461,-1.835,1.14,79,85,-0.137,6,6,41,0.182222222222222,"helix",-2.9,5.08,0.0019404915912031,28.1422962648557,28.1422937171073,28.1176868093208,83.7298318312042,30,-31,0,0,-31,0,0,0,0,4,2,0,4,0,0,0,0,3,4,-1,-2,-8,0,-10,-6,-0.419452887537994,0.766156462585034,0.1830072334443,-0.312872975277067,0.640449438202247,0.831578947368421,-0.112850082372323,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-0.332,-0.038,"6:5","147/150","N:C:R:F:H:E:Y:Q:W:D:A:S",3.33727355927796,7.45865029764653e-10,0.542113710503027,6.15603976549737,10.8149160259451,96.0464157669383,1.44935953071313,1.80101596312758e-14,13.744482437837,9.60105095933572,112.1508500808,5.67227891121513e-20,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR2516636","ERR2516636","lineage4.3.4.1","pe","Peru","pnca_p.gln141pro","A","H","GLN","QA141","pnca_complex.pdb"
|
|
"Q141P","L2","PZA","Q","Q141",141,"P",1,"MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",8.108,-1.656,0.901,5.02461,-1.835,1.14,79,85,-0.137,6,6,41,0.182222222222222,"helix",-2.9,5.08,0.0019404915912031,28.1422962648557,28.1422937171073,28.1176868093208,83.7298318312042,30,-31,0,0,-31,0,0,0,0,4,2,0,4,0,0,0,0,3,4,-1,-2,-8,0,-10,-6,-0.419452887537994,0.766156462585034,0.1830072334443,-0.312872975277067,0.640449438202247,0.831578947368421,-0.112850082372323,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-0.332,-0.038,"6:5","147/150","N:C:R:F:H:E:Y:Q:W:D:A:S",3.33727355927796,7.45865029764653e-10,0.542113710503027,6.15603976549737,10.8149160259451,96.0464157669383,1.44935953071313,1.80101596312758e-14,13.744482437837,9.60105095933572,112.1508500808,5.67227891121513e-20,"lineage2","dr_mutations_pyrazinamide","PRO",0,"MDR_14226","SRR6824368","lineage2.2.1","cn","China: Jinxian County, Nanchang City, Jiangxi Province","pnca_p.gln141pro","A","H","GLN","QA141","pnca_complex.pdb"
|
|
"Q141P","L5","PZA","Q","Q141",141,"P",NA,"MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",8.108,-1.656,0.901,5.02461,-1.835,1.14,79,85,-0.137,6,6,41,0.182222222222222,"helix",-2.9,5.08,0.0019404915912031,28.1422962648557,28.1422937171073,28.1176868093208,83.7298318312042,30,-31,0,0,-31,0,0,0,0,4,2,0,4,0,0,0,0,3,4,-1,-2,-8,0,-10,-6,-0.419452887537994,0.766156462585034,0.1830072334443,-0.312872975277067,0.640449438202247,0.831578947368421,-0.112850082372323,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-0.332,-0.038,"6:5","147/150","N:C:R:F:H:E:Y:Q:W:D:A:S",3.33727355927796,7.45865029764653e-10,0.542113710503027,6.15603976549737,10.8149160259451,96.0464157669383,1.44935953071313,1.80101596312758e-14,13.744482437837,9.60105095933572,112.1508500808,5.67227891121513e-20,"lineage5","dr_mutations_pyrazinamide","PRO",0,"ERR1215474","ERR1215474","lineage5","gh","Ghana","pnca_p.gln141pro","A","H","GLN","QA141","pnca_complex.pdb"
|
|
"Q141P","L2","PZA","Q","Q141",141,"P",0,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",8.108,-1.656,0.901,5.02461,-1.835,1.14,79,85,-0.137,6,6,41,0.182222222222222,"helix",-2.9,5.08,0.0019404915912031,28.1422962648557,28.1422937171073,28.1176868093208,83.7298318312042,30,-31,0,0,-31,0,0,0,0,4,2,0,4,0,0,0,0,3,4,-1,-2,-8,0,-10,-6,-0.419452887537994,0.766156462585034,0.1830072334443,-0.312872975277067,0.640449438202247,0.831578947368421,-0.112850082372323,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-0.332,-0.038,"6:5","147/150","N:C:R:F:H:E:Y:Q:W:D:A:S",3.33727355927796,7.45865029764653e-10,0.542113710503027,6.15603976549737,10.8149160259451,96.0464157669383,1.44935953071313,1.80101596312758e-14,13.744482437837,9.60105095933572,112.1508500808,5.67227891121513e-20,"lineage2","dr_mutations_pyrazinamide","PRO",0,"ERS456766","ERR550645_ERR550647_ERR550646","lineage2.2.1","uz","Nukus","pnca_p.gln141pro","A","H","GLN","QA141","pnca_complex.pdb"
|
|
"Q141P","L2","PZA","Q","Q141",141,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",8.108,-1.656,0.901,5.02461,-1.835,1.14,79,85,-0.137,6,6,41,0.182222222222222,"helix",-2.9,5.08,0.0019404915912031,28.1422962648557,28.1422937171073,28.1176868093208,83.7298318312042,30,-31,0,0,-31,0,0,0,0,4,2,0,4,0,0,0,0,3,4,-1,-2,-8,0,-10,-6,-0.419452887537994,0.766156462585034,0.1830072334443,-0.312872975277067,0.640449438202247,0.831578947368421,-0.112850082372323,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-0.332,-0.038,"6:5","147/150","N:C:R:F:H:E:Y:Q:W:D:A:S",3.33727355927796,7.45865029764653e-10,0.542113710503027,6.15603976549737,10.8149160259451,96.0464157669383,1.44935953071313,1.80101596312758e-14,13.744482437837,9.60105095933572,112.1508500808,5.67227891121513e-20,"lineage2","dr_mutations_pyrazinamide","PRO",0,"ERR553208,SAMEA2535213,ERS458615","ERR553208","lineage2.2.1","uz","Nukus","pnca_p.gln141pro","A","H","GLN","QA141","pnca_complex.pdb"
|
|
"Q141P","L2","PZA","Q","Q141",141,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",8.108,-1.656,0.901,5.02461,-1.835,1.14,79,85,-0.137,6,6,41,0.182222222222222,"helix",-2.9,5.08,0.0019404915912031,28.1422962648557,28.1422937171073,28.1176868093208,83.7298318312042,30,-31,0,0,-31,0,0,0,0,4,2,0,4,0,0,0,0,3,4,-1,-2,-8,0,-10,-6,-0.419452887537994,0.766156462585034,0.1830072334443,-0.312872975277067,0.640449438202247,0.831578947368421,-0.112850082372323,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-0.332,-0.038,"6:5","147/150","N:C:R:F:H:E:Y:Q:W:D:A:S",3.33727355927796,7.45865029764653e-10,0.542113710503027,6.15603976549737,10.8149160259451,96.0464157669383,1.44935953071313,1.80101596312758e-14,13.744482437837,9.60105095933572,112.1508500808,5.67227891121513e-20,"lineage2","dr_mutations_pyrazinamide","PRO",0,"ERR2516949","ERR2516949","lineage2.2.1","gb","UK","pnca_p.gln141pro","A","H","GLN","QA141","pnca_complex.pdb"
|
|
"Q141P","L2","PZA","Q","Q141",141,"P",NA,"Other","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",8.108,-1.656,0.901,5.02461,-1.835,1.14,79,85,-0.137,6,6,41,0.182222222222222,"helix",-2.9,5.08,0.0019404915912031,28.1422962648557,28.1422937171073,28.1176868093208,83.7298318312042,30,-31,0,0,-31,0,0,0,0,4,2,0,4,0,0,0,0,3,4,-1,-2,-8,0,-10,-6,-0.419452887537994,0.766156462585034,0.1830072334443,-0.312872975277067,0.640449438202247,0.831578947368421,-0.112850082372323,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-0.332,-0.038,"6:5","147/150","N:C:R:F:H:E:Y:Q:W:D:A:S",3.33727355927796,7.45865029764653e-10,0.542113710503027,6.15603976549737,10.8149160259451,96.0464157669383,1.44935953071313,1.80101596312758e-14,13.744482437837,9.60105095933572,112.1508500808,5.67227891121513e-20,"lineage2","dr_mutations_pyrazinamide","PRO",0,"SAMN02360566","SRR1048879_SRR1013574_SRR1048880_SRR1013573","lineage2.2.2","kr","South Korea","pnca_p.gln141pro","A","H","GLN","QA141","pnca_complex.pdb"
|
|
"Q141P","L4","PZA","Q","Q141",141,"P",NA,"MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",8.108,-1.656,0.901,5.02461,-1.835,1.14,79,85,-0.137,6,6,41,0.182222222222222,"helix",-2.9,5.08,0.0019404915912031,28.1422962648557,28.1422937171073,28.1176868093208,83.7298318312042,30,-31,0,0,-31,0,0,0,0,4,2,0,4,0,0,0,0,3,4,-1,-2,-8,0,-10,-6,-0.419452887537994,0.766156462585034,0.1830072334443,-0.312872975277067,0.640449438202247,0.831578947368421,-0.112850082372323,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-0.332,-0.038,"6:5","147/150","N:C:R:F:H:E:Y:Q:W:D:A:S",3.33727355927796,7.45865029764653e-10,0.542113710503027,6.15603976549737,10.8149160259451,96.0464157669383,1.44935953071313,1.80101596312758e-14,13.744482437837,9.60105095933572,112.1508500808,5.67227891121513e-20,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR181986","ERR181986","lineage4.3.4.2.1","mw","Malawi","pnca_p.gln141pro","A","H","GLN","QA141","pnca_complex.pdb"
|
|
"Q141P","L2","PZA","Q","Q141",141,"P",NA,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",8.108,-1.656,0.901,5.02461,-1.835,1.14,79,85,-0.137,6,6,41,0.182222222222222,"helix",-2.9,5.08,0.0019404915912031,28.1422962648557,28.1422937171073,28.1176868093208,83.7298318312042,30,-31,0,0,-31,0,0,0,0,4,2,0,4,0,0,0,0,3,4,-1,-2,-8,0,-10,-6,-0.419452887537994,0.766156462585034,0.1830072334443,-0.312872975277067,0.640449438202247,0.831578947368421,-0.112850082372323,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-0.332,-0.038,"6:5","147/150","N:C:R:F:H:E:Y:Q:W:D:A:S",3.33727355927796,7.45865029764653e-10,0.542113710503027,6.15603976549737,10.8149160259451,96.0464157669383,1.44935953071313,1.80101596312758e-14,13.744482437837,9.60105095933572,112.1508500808,5.67227891121513e-20,"lineage2","dr_mutations_pyrazinamide","PRO",0,"SRR8237400","SRR8237400","lineage2.2.1","us","","pnca_p.gln141pro","A","H","GLN","QA141","pnca_complex.pdb"
|
|
"Q141P","L3","PZA","Q","Q141",141,"P",1,"XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",8.108,-1.656,0.901,5.02461,-1.835,1.14,79,85,-0.137,6,6,41,0.182222222222222,"helix",-2.9,5.08,0.0019404915912031,28.1422962648557,28.1422937171073,28.1176868093208,83.7298318312042,30,-31,0,0,-31,0,0,0,0,4,2,0,4,0,0,0,0,3,4,-1,-2,-8,0,-10,-6,-0.419452887537994,0.766156462585034,0.1830072334443,-0.312872975277067,0.640449438202247,0.831578947368421,-0.112850082372323,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-0.332,-0.038,"6:5","147/150","N:C:R:F:H:E:Y:Q:W:D:A:S",3.33727355927796,7.45865029764653e-10,0.542113710503027,6.15603976549737,10.8149160259451,96.0464157669383,1.44935953071313,1.80101596312758e-14,13.744482437837,9.60105095933572,112.1508500808,5.67227891121513e-20,"lineage3","dr_mutations_pyrazinamide","PRO",0,"ERR3335724","ERR3335724","lineage3","pk","Pakistan","pnca_p.gln141pro","A","H","GLN","QA141","pnca_complex.pdb"
|
|
"Q141P","L2","PZA","Q","Q141",141,"P",1,"MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",8.108,-1.656,0.901,5.02461,-1.835,1.14,79,85,-0.137,6,6,41,0.182222222222222,"helix",-2.9,5.08,0.0019404915912031,28.1422962648557,28.1422937171073,28.1176868093208,83.7298318312042,30,-31,0,0,-31,0,0,0,0,4,2,0,4,0,0,0,0,3,4,-1,-2,-8,0,-10,-6,-0.419452887537994,0.766156462585034,0.1830072334443,-0.312872975277067,0.640449438202247,0.831578947368421,-0.112850082372323,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-0.332,-0.038,"6:5","147/150","N:C:R:F:H:E:Y:Q:W:D:A:S",3.33727355927796,7.45865029764653e-10,0.542113710503027,6.15603976549737,10.8149160259451,96.0464157669383,1.44935953071313,1.80101596312758e-14,13.744482437837,9.60105095933572,112.1508500808,5.67227891121513e-20,"lineage2","dr_mutations_pyrazinamide","PRO",0,"ERR133880,0532E-sc-2012-02-09T18:56:20Z-1355213","ERR133880","lineage2.2.1","ru","Russia,Samara","pnca_p.gln141pro","A","H","GLN","QA141","pnca_complex.pdb"
|
|
"Q141P","L4","PZA","Q","Q141",141,"P",NA,"MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",8.108,-1.656,0.901,5.02461,-1.835,1.14,79,85,-0.137,6,6,41,0.182222222222222,"helix",-2.9,5.08,0.0019404915912031,28.1422962648557,28.1422937171073,28.1176868093208,83.7298318312042,30,-31,0,0,-31,0,0,0,0,4,2,0,4,0,0,0,0,3,4,-1,-2,-8,0,-10,-6,-0.419452887537994,0.766156462585034,0.1830072334443,-0.312872975277067,0.640449438202247,0.831578947368421,-0.112850082372323,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-0.332,-0.038,"6:5","147/150","N:C:R:F:H:E:Y:Q:W:D:A:S",3.33727355927796,7.45865029764653e-10,0.542113710503027,6.15603976549737,10.8149160259451,96.0464157669383,1.44935953071313,1.80101596312758e-14,13.744482437837,9.60105095933572,112.1508500808,5.67227891121513e-20,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR2707025","ERR2707025","lineage4.3.4.1","cd","Democratic Republic of Congo","pnca_p.gln141pro","A","H","GLN","QA141","pnca_complex.pdb"
|
|
"Q141P","L4","PZA","Q","Q141",141,"P",1,"MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",8.108,-1.656,0.901,5.02461,-1.835,1.14,79,85,-0.137,6,6,41,0.182222222222222,"helix",-2.9,5.08,0.0019404915912031,28.1422962648557,28.1422937171073,28.1176868093208,83.7298318312042,30,-31,0,0,-31,0,0,0,0,4,2,0,4,0,0,0,0,3,4,-1,-2,-8,0,-10,-6,-0.419452887537994,0.766156462585034,0.1830072334443,-0.312872975277067,0.640449438202247,0.831578947368421,-0.112850082372323,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-0.332,-0.038,"6:5","147/150","N:C:R:F:H:E:Y:Q:W:D:A:S",3.33727355927796,7.45865029764653e-10,0.542113710503027,6.15603976549737,10.8149160259451,96.0464157669383,1.44935953071313,1.80101596312758e-14,13.744482437837,9.60105095933572,112.1508500808,5.67227891121513e-20,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR176629","ERR176629","lineage4.3.4.2.1","mw","Malawi","pnca_p.gln141pro","A","H","GLN","QA141","pnca_complex.pdb"
|
|
"Q141P","L3","PZA","Q","Q141",141,"P",0,"Pre-MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",8.108,-1.656,0.901,5.02461,-1.835,1.14,79,85,-0.137,6,6,41,0.182222222222222,"helix",-2.9,5.08,0.0019404915912031,28.1422962648557,28.1422937171073,28.1176868093208,83.7298318312042,30,-31,0,0,-31,0,0,0,0,4,2,0,4,0,0,0,0,3,4,-1,-2,-8,0,-10,-6,-0.419452887537994,0.766156462585034,0.1830072334443,-0.312872975277067,0.640449438202247,0.831578947368421,-0.112850082372323,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-0.332,-0.038,"6:5","147/150","N:C:R:F:H:E:Y:Q:W:D:A:S",3.33727355927796,7.45865029764653e-10,0.542113710503027,6.15603976549737,10.8149160259451,96.0464157669383,1.44935953071313,1.80101596312758e-14,13.744482437837,9.60105095933572,112.1508500808,5.67227891121513e-20,"lineage3","dr_mutations_pyrazinamide","PRO",0,"ERR2510501","ERR2510501","lineage3","pk","Pakistan","pnca_p.gln141pro","A","H","GLN","QA141","pnca_complex.pdb"
|
|
"Q141P","L4","PZA","Q","Q141",141,"P",NA,"MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",8.108,-1.656,0.901,5.02461,-1.835,1.14,79,85,-0.137,6,6,41,0.182222222222222,"helix",-2.9,5.08,0.0019404915912031,28.1422962648557,28.1422937171073,28.1176868093208,83.7298318312042,30,-31,0,0,-31,0,0,0,0,4,2,0,4,0,0,0,0,3,4,-1,-2,-8,0,-10,-6,-0.419452887537994,0.766156462585034,0.1830072334443,-0.312872975277067,0.640449438202247,0.831578947368421,-0.112850082372323,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-0.332,-0.038,"6:5","147/150","N:C:R:F:H:E:Y:Q:W:D:A:S",3.33727355927796,7.45865029764653e-10,0.542113710503027,6.15603976549737,10.8149160259451,96.0464157669383,1.44935953071313,1.80101596312758e-14,13.744482437837,9.60105095933572,112.1508500808,5.67227891121513e-20,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR2706925","ERR2706925","lineage4.6.1.2","cd","Democratic Republic of Congo","pnca_p.gln141pro","A","H","GLN","QA141","pnca_complex.pdb"
|
|
"Q141P","L2","PZA","Q","Q141",141,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",8.108,-1.656,0.901,5.02461,-1.835,1.14,79,85,-0.137,6,6,41,0.182222222222222,"helix",-2.9,5.08,0.0019404915912031,28.1422962648557,28.1422937171073,28.1176868093208,83.7298318312042,30,-31,0,0,-31,0,0,0,0,4,2,0,4,0,0,0,0,3,4,-1,-2,-8,0,-10,-6,-0.419452887537994,0.766156462585034,0.1830072334443,-0.312872975277067,0.640449438202247,0.831578947368421,-0.112850082372323,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-0.332,-0.038,"6:5","147/150","N:C:R:F:H:E:Y:Q:W:D:A:S",3.33727355927796,7.45865029764653e-10,0.542113710503027,6.15603976549737,10.8149160259451,96.0464157669383,1.44935953071313,1.80101596312758e-14,13.744482437837,9.60105095933572,112.1508500808,5.67227891121513e-20,"lineage2","dr_mutations_pyrazinamide","PRO",0,"ERR2516812","ERR2516812","lineage2.2.1","gb","UK","pnca_p.gln141pro","A","H","GLN","QA141","pnca_complex.pdb"
|
|
"Q141P","L2","PZA","Q","Q141",141,"P",1,"MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",8.108,-1.656,0.901,5.02461,-1.835,1.14,79,85,-0.137,6,6,41,0.182222222222222,"helix",-2.9,5.08,0.0019404915912031,28.1422962648557,28.1422937171073,28.1176868093208,83.7298318312042,30,-31,0,0,-31,0,0,0,0,4,2,0,4,0,0,0,0,3,4,-1,-2,-8,0,-10,-6,-0.419452887537994,0.766156462585034,0.1830072334443,-0.312872975277067,0.640449438202247,0.831578947368421,-0.112850082372323,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-0.332,-0.038,"6:5","147/150","N:C:R:F:H:E:Y:Q:W:D:A:S",3.33727355927796,7.45865029764653e-10,0.542113710503027,6.15603976549737,10.8149160259451,96.0464157669383,1.44935953071313,1.80101596312758e-14,13.744482437837,9.60105095933572,112.1508500808,5.67227891121513e-20,"lineage2","dr_mutations_pyrazinamide","PRO",0,"ERR2517125","ERR2517125","lineage2.2.1.1","gb","UK","pnca_p.gln141pro","A","H","GLN","QA141","pnca_complex.pdb"
|
|
"Q141P","L4","PZA","Q","Q141",141,"P",NA,"MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",8.108,-1.656,0.901,5.02461,-1.835,1.14,79,85,-0.137,6,6,41,0.182222222222222,"helix",-2.9,5.08,0.0019404915912031,28.1422962648557,28.1422937171073,28.1176868093208,83.7298318312042,30,-31,0,0,-31,0,0,0,0,4,2,0,4,0,0,0,0,3,4,-1,-2,-8,0,-10,-6,-0.419452887537994,0.766156462585034,0.1830072334443,-0.312872975277067,0.640449438202247,0.831578947368421,-0.112850082372323,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-0.332,-0.038,"6:5","147/150","N:C:R:F:H:E:Y:Q:W:D:A:S",3.33727355927796,7.45865029764653e-10,0.542113710503027,6.15603976549737,10.8149160259451,96.0464157669383,1.44935953071313,1.80101596312758e-14,13.744482437837,9.60105095933572,112.1508500808,5.67227891121513e-20,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR221617","ERR221617","lineage4.3.4.2.1","mw","Malawi","pnca_p.gln141pro","A","H","GLN","QA141","pnca_complex.pdb"
|
|
"Q141P","L2","PZA","Q","Q141",141,"P",NA,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",8.108,-1.656,0.901,5.02461,-1.835,1.14,79,85,-0.137,6,6,41,0.182222222222222,"helix",-2.9,5.08,0.0019404915912031,28.1422962648557,28.1422937171073,28.1176868093208,83.7298318312042,30,-31,0,0,-31,0,0,0,0,4,2,0,4,0,0,0,0,3,4,-1,-2,-8,0,-10,-6,-0.419452887537994,0.766156462585034,0.1830072334443,-0.312872975277067,0.640449438202247,0.831578947368421,-0.112850082372323,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-0.332,-0.038,"6:5","147/150","N:C:R:F:H:E:Y:Q:W:D:A:S",3.33727355927796,7.45865029764653e-10,0.542113710503027,6.15603976549737,10.8149160259451,96.0464157669383,1.44935953071313,1.80101596312758e-14,13.744482437837,9.60105095933572,112.1508500808,5.67227891121513e-20,"lineage2","dr_mutations_pyrazinamide","PRO",0,"SRR5709869","SRR5709869","lineage2.2.1","th","Thailand","pnca_p.gln141pro","A","H","GLN","QA141","pnca_complex.pdb"
|
|
"Q141P","L4","PZA","Q","Q141",141,"P",NA,"MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",8.108,-1.656,0.901,5.02461,-1.835,1.14,79,85,-0.137,6,6,41,0.182222222222222,"helix",-2.9,5.08,0.0019404915912031,28.1422962648557,28.1422937171073,28.1176868093208,83.7298318312042,30,-31,0,0,-31,0,0,0,0,4,2,0,4,0,0,0,0,3,4,-1,-2,-8,0,-10,-6,-0.419452887537994,0.766156462585034,0.1830072334443,-0.312872975277067,0.640449438202247,0.831578947368421,-0.112850082372323,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-0.332,-0.038,"6:5","147/150","N:C:R:F:H:E:Y:Q:W:D:A:S",3.33727355927796,7.45865029764653e-10,0.542113710503027,6.15603976549737,10.8149160259451,96.0464157669383,1.44935953071313,1.80101596312758e-14,13.744482437837,9.60105095933572,112.1508500808,5.67227891121513e-20,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR221616","ERR221616","lineage4.3.4.2.1","mw","Malawi","pnca_p.gln141pro","A","H","GLN","QA141","pnca_complex.pdb"
|
|
"Q141P","L4","PZA","Q","Q141",141,"P",1,"MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",8.108,-1.656,0.901,5.02461,-1.835,1.14,79,85,-0.137,6,6,41,0.182222222222222,"helix",-2.9,5.08,0.0019404915912031,28.1422962648557,28.1422937171073,28.1176868093208,83.7298318312042,30,-31,0,0,-31,0,0,0,0,4,2,0,4,0,0,0,0,3,4,-1,-2,-8,0,-10,-6,-0.419452887537994,0.766156462585034,0.1830072334443,-0.312872975277067,0.640449438202247,0.831578947368421,-0.112850082372323,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-0.332,-0.038,"6:5","147/150","N:C:R:F:H:E:Y:Q:W:D:A:S",3.33727355927796,7.45865029764653e-10,0.542113710503027,6.15603976549737,10.8149160259451,96.0464157669383,1.44935953071313,1.80101596312758e-14,13.744482437837,9.60105095933572,112.1508500808,5.67227891121513e-20,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR036188","ERR036188","lineage4.3.4.2.1","mw","Malawi","pnca_p.gln141pro","A","H","GLN","QA141","pnca_complex.pdb"
|
|
"Q141P","L2","PZA","Q","Q141",141,"P",NA,"MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",8.108,-1.656,0.901,5.02461,-1.835,1.14,79,85,-0.137,6,6,41,0.182222222222222,"helix",-2.9,5.08,0.0019404915912031,28.1422962648557,28.1422937171073,28.1176868093208,83.7298318312042,30,-31,0,0,-31,0,0,0,0,4,2,0,4,0,0,0,0,3,4,-1,-2,-8,0,-10,-6,-0.419452887537994,0.766156462585034,0.1830072334443,-0.312872975277067,0.640449438202247,0.831578947368421,-0.112850082372323,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-0.332,-0.038,"6:5","147/150","N:C:R:F:H:E:Y:Q:W:D:A:S",3.33727355927796,7.45865029764653e-10,0.542113710503027,6.15603976549737,10.8149160259451,96.0464157669383,1.44935953071313,1.80101596312758e-14,13.744482437837,9.60105095933572,112.1508500808,5.67227891121513e-20,"lineage2","dr_mutations_pyrazinamide","PRO",0,"SRS796992","SRR1723482_SRR1723483","lineage2.2.1","cn","China:Jiangxi","pnca_p.gln141pro","A","H","GLN","QA141","pnca_complex.pdb"
|
|
"Q141P","L2","PZA","Q","Q141",141,"P",NA,"XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",8.108,-1.656,0.901,5.02461,-1.835,1.14,79,85,-0.137,6,6,41,0.182222222222222,"helix",-2.9,5.08,0.0019404915912031,28.1422962648557,28.1422937171073,28.1176868093208,83.7298318312042,30,-31,0,0,-31,0,0,0,0,4,2,0,4,0,0,0,0,3,4,-1,-2,-8,0,-10,-6,-0.419452887537994,0.766156462585034,0.1830072334443,-0.312872975277067,0.640449438202247,0.831578947368421,-0.112850082372323,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-0.332,-0.038,"6:5","147/150","N:C:R:F:H:E:Y:Q:W:D:A:S",3.33727355927796,7.45865029764653e-10,0.542113710503027,6.15603976549737,10.8149160259451,96.0464157669383,1.44935953071313,1.80101596312758e-14,13.744482437837,9.60105095933572,112.1508500808,5.67227891121513e-20,"lineage2","dr_mutations_pyrazinamide","PRO",0,"SAMN07236518,SRR5709891","SRR5709891","lineage2.2.1","th","Thailand","pnca_p.gln141pro","A","H","GLN","QA141","pnca_complex.pdb"
|
|
"Q141P","L4","PZA","Q","Q141",141,"P",NA,"MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",8.108,-1.656,0.901,5.02461,-1.835,1.14,79,85,-0.137,6,6,41,0.182222222222222,"helix",-2.9,5.08,0.0019404915912031,28.1422962648557,28.1422937171073,28.1176868093208,83.7298318312042,30,-31,0,0,-31,0,0,0,0,4,2,0,4,0,0,0,0,3,4,-1,-2,-8,0,-10,-6,-0.419452887537994,0.766156462585034,0.1830072334443,-0.312872975277067,0.640449438202247,0.831578947368421,-0.112850082372323,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-0.332,-0.038,"6:5","147/150","N:C:R:F:H:E:Y:Q:W:D:A:S",3.33727355927796,7.45865029764653e-10,0.542113710503027,6.15603976549737,10.8149160259451,96.0464157669383,1.44935953071313,1.80101596312758e-14,13.744482437837,9.60105095933572,112.1508500808,5.67227891121513e-20,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR2707026","ERR2707026","lineage4.6.1.2","cd","Democratic Republic of Congo","pnca_p.gln141pro","A","H","GLN","QA141","pnca_complex.pdb"
|
|
"Q141P","L4","PZA","Q","Q141",141,"P",NA,"MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",8.108,-1.656,0.901,5.02461,-1.835,1.14,79,85,-0.137,6,6,41,0.182222222222222,"helix",-2.9,5.08,0.0019404915912031,28.1422962648557,28.1422937171073,28.1176868093208,83.7298318312042,30,-31,0,0,-31,0,0,0,0,4,2,0,4,0,0,0,0,3,4,-1,-2,-8,0,-10,-6,-0.419452887537994,0.766156462585034,0.1830072334443,-0.312872975277067,0.640449438202247,0.831578947368421,-0.112850082372323,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-0.332,-0.038,"6:5","147/150","N:C:R:F:H:E:Y:Q:W:D:A:S",3.33727355927796,7.45865029764653e-10,0.542113710503027,6.15603976549737,10.8149160259451,96.0464157669383,1.44935953071313,1.80101596312758e-14,13.744482437837,9.60105095933572,112.1508500808,5.67227891121513e-20,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR1199113","ERR1199113","lineage4.6.1.2","cd","Democratic Republic of the Congo","pnca_p.gln141pro","A","H","GLN","QA141","pnca_complex.pdb"
|
|
"Q141P","L2","PZA","Q","Q141",141,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",8.108,-1.656,0.901,5.02461,-1.835,1.14,79,85,-0.137,6,6,41,0.182222222222222,"helix",-2.9,5.08,0.0019404915912031,28.1422962648557,28.1422937171073,28.1176868093208,83.7298318312042,30,-31,0,0,-31,0,0,0,0,4,2,0,4,0,0,0,0,3,4,-1,-2,-8,0,-10,-6,-0.419452887537994,0.766156462585034,0.1830072334443,-0.312872975277067,0.640449438202247,0.831578947368421,-0.112850082372323,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-0.332,-0.038,"6:5","147/150","N:C:R:F:H:E:Y:Q:W:D:A:S",3.33727355927796,7.45865029764653e-10,0.542113710503027,6.15603976549737,10.8149160259451,96.0464157669383,1.44935953071313,1.80101596312758e-14,13.744482437837,9.60105095933572,112.1508500808,5.67227891121513e-20,"lineage2","dr_mutations_pyrazinamide","PRO",0,"ERS456968","ERR550923_ERR550922","lineage2.2.1","uz","Nukus","pnca_p.gln141pro","A","H","GLN","QA141","pnca_complex.pdb"
|
|
"Q141P","L2","PZA","Q","Q141",141,"P",NA,"MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",8.108,-1.656,0.901,5.02461,-1.835,1.14,79,85,-0.137,6,6,41,0.182222222222222,"helix",-2.9,5.08,0.0019404915912031,28.1422962648557,28.1422937171073,28.1176868093208,83.7298318312042,30,-31,0,0,-31,0,0,0,0,4,2,0,4,0,0,0,0,3,4,-1,-2,-8,0,-10,-6,-0.419452887537994,0.766156462585034,0.1830072334443,-0.312872975277067,0.640449438202247,0.831578947368421,-0.112850082372323,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-0.332,-0.038,"6:5","147/150","N:C:R:F:H:E:Y:Q:W:D:A:S",3.33727355927796,7.45865029764653e-10,0.542113710503027,6.15603976549737,10.8149160259451,96.0464157669383,1.44935953071313,1.80101596312758e-14,13.744482437837,9.60105095933572,112.1508500808,5.67227891121513e-20,"lineage2","dr_mutations_pyrazinamide","PRO",0,"DRR185037","DRR185037","lineage2.2.1","vn","Vietnam","pnca_p.gln141pro","A","H","GLN","QA141","pnca_complex.pdb"
|
|
"Q141P","L4","PZA","Q","Q141",141,"P",NA,"MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",8.108,-1.656,0.901,5.02461,-1.835,1.14,79,85,-0.137,6,6,41,0.182222222222222,"helix",-2.9,5.08,0.0019404915912031,28.1422962648557,28.1422937171073,28.1176868093208,83.7298318312042,30,-31,0,0,-31,0,0,0,0,4,2,0,4,0,0,0,0,3,4,-1,-2,-8,0,-10,-6,-0.419452887537994,0.766156462585034,0.1830072334443,-0.312872975277067,0.640449438202247,0.831578947368421,-0.112850082372323,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-0.332,-0.038,"6:5","147/150","N:C:R:F:H:E:Y:Q:W:D:A:S",3.33727355927796,7.45865029764653e-10,0.542113710503027,6.15603976549737,10.8149160259451,96.0464157669383,1.44935953071313,1.80101596312758e-14,13.744482437837,9.60105095933572,112.1508500808,5.67227891121513e-20,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR190370","ERR190370","lineage4.3.4.2.1","mw","Malawi","pnca_p.gln141pro","A","H","GLN","QA141","pnca_complex.pdb"
|
|
"Q141P","L2","PZA","Q","Q141",141,"P",1,"MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",8.108,-1.656,0.901,5.02461,-1.835,1.14,79,85,-0.137,6,6,41,0.182222222222222,"helix",-2.9,5.08,0.0019404915912031,28.1422962648557,28.1422937171073,28.1176868093208,83.7298318312042,30,-31,0,0,-31,0,0,0,0,4,2,0,4,0,0,0,0,3,4,-1,-2,-8,0,-10,-6,-0.419452887537994,0.766156462585034,0.1830072334443,-0.312872975277067,0.640449438202247,0.831578947368421,-0.112850082372323,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-0.332,-0.038,"6:5","147/150","N:C:R:F:H:E:Y:Q:W:D:A:S",3.33727355927796,7.45865029764653e-10,0.542113710503027,6.15603976549737,10.8149160259451,96.0464157669383,1.44935953071313,1.80101596312758e-14,13.744482437837,9.60105095933572,112.1508500808,5.67227891121513e-20,"lineage2","dr_mutations_pyrazinamide","PRO",0,"SAMN10961332","SRR8651652","lineage2.1","cn","China:Wenzhou","pnca_p.gln141pro","A","H","GLN","QA141","pnca_complex.pdb"
|
|
"Q141P","L4","PZA","Q","Q141",141,"P",NA,"MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",8.108,-1.656,0.901,5.02461,-1.835,1.14,79,85,-0.137,6,6,41,0.182222222222222,"helix",-2.9,5.08,0.0019404915912031,28.1422962648557,28.1422937171073,28.1176868093208,83.7298318312042,30,-31,0,0,-31,0,0,0,0,4,2,0,4,0,0,0,0,3,4,-1,-2,-8,0,-10,-6,-0.419452887537994,0.766156462585034,0.1830072334443,-0.312872975277067,0.640449438202247,0.831578947368421,-0.112850082372323,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-0.332,-0.038,"6:5","147/150","N:C:R:F:H:E:Y:Q:W:D:A:S",3.33727355927796,7.45865029764653e-10,0.542113710503027,6.15603976549737,10.8149160259451,96.0464157669383,1.44935953071313,1.80101596312758e-14,13.744482437837,9.60105095933572,112.1508500808,5.67227891121513e-20,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR2707024","ERR2707024","lineage4.6.1.2","cd","Democratic Republic of Congo","pnca_p.gln141pro","A","H","GLN","QA141","pnca_complex.pdb"
|
|
"Q141P","L2","PZA","Q","Q141",141,"P",NA,"Pre-MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",8.108,-1.656,0.901,5.02461,-1.835,1.14,79,85,-0.137,6,6,41,0.182222222222222,"helix",-2.9,5.08,0.0019404915912031,28.1422962648557,28.1422937171073,28.1176868093208,83.7298318312042,30,-31,0,0,-31,0,0,0,0,4,2,0,4,0,0,0,0,3,4,-1,-2,-8,0,-10,-6,-0.419452887537994,0.766156462585034,0.1830072334443,-0.312872975277067,0.640449438202247,0.831578947368421,-0.112850082372323,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-0.332,-0.038,"6:5","147/150","N:C:R:F:H:E:Y:Q:W:D:A:S",3.33727355927796,7.45865029764653e-10,0.542113710503027,6.15603976549737,10.8149160259451,96.0464157669383,1.44935953071313,1.80101596312758e-14,13.744482437837,9.60105095933572,112.1508500808,5.67227891121513e-20,"lineage2","dr_mutations_pyrazinamide","PRO",0,"SAMN07236324,SRR5709865","SRR5709865","lineage2.2.1","th","Thailand","pnca_p.gln141pro","A","H","GLN","QA141","pnca_complex.pdb"
|
|
"Q141P","L2","PZA","Q","Q141",141,"P",NA,"Pre-MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",8.108,-1.656,0.901,5.02461,-1.835,1.14,79,85,-0.137,6,6,41,0.182222222222222,"helix",-2.9,5.08,0.0019404915912031,28.1422962648557,28.1422937171073,28.1176868093208,83.7298318312042,30,-31,0,0,-31,0,0,0,0,4,2,0,4,0,0,0,0,3,4,-1,-2,-8,0,-10,-6,-0.419452887537994,0.766156462585034,0.1830072334443,-0.312872975277067,0.640449438202247,0.831578947368421,-0.112850082372323,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-0.332,-0.038,"6:5","147/150","N:C:R:F:H:E:Y:Q:W:D:A:S",3.33727355927796,7.45865029764653e-10,0.542113710503027,6.15603976549737,10.8149160259451,96.0464157669383,1.44935953071313,1.80101596312758e-14,13.744482437837,9.60105095933572,112.1508500808,5.67227891121513e-20,"lineage2","dr_mutations_pyrazinamide","PRO",0,"DRR184631","DRR184631","lineage2.2.1","vn","Vietnam","pnca_p.gln141pro","A","H","GLN","QA141","pnca_complex.pdb"
|
|
"Q141P","L4","PZA","Q","Q141",141,"P",NA,"MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",8.108,-1.656,0.901,5.02461,-1.835,1.14,79,85,-0.137,6,6,41,0.182222222222222,"helix",-2.9,5.08,0.0019404915912031,28.1422962648557,28.1422937171073,28.1176868093208,83.7298318312042,30,-31,0,0,-31,0,0,0,0,4,2,0,4,0,0,0,0,3,4,-1,-2,-8,0,-10,-6,-0.419452887537994,0.766156462585034,0.1830072334443,-0.312872975277067,0.640449438202247,0.831578947368421,-0.112850082372323,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-0.332,-0.038,"6:5","147/150","N:C:R:F:H:E:Y:Q:W:D:A:S",3.33727355927796,7.45865029764653e-10,0.542113710503027,6.15603976549737,10.8149160259451,96.0464157669383,1.44935953071313,1.80101596312758e-14,13.744482437837,9.60105095933572,112.1508500808,5.67227891121513e-20,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR1199105","ERR1199105","lineage4.6.1.2","cd","Democratic Republic of the Congo","pnca_p.gln141pro","A","H","GLN","QA141","pnca_complex.pdb"
|
|
"Q141P","L4","PZA","Q","Q141",141,"P",1,"MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",8.108,-1.656,0.901,5.02461,-1.835,1.14,79,85,-0.137,6,6,41,0.182222222222222,"helix",-2.9,5.08,0.0019404915912031,28.1422962648557,28.1422937171073,28.1176868093208,83.7298318312042,30,-31,0,0,-31,0,0,0,0,4,2,0,4,0,0,0,0,3,4,-1,-2,-8,0,-10,-6,-0.419452887537994,0.766156462585034,0.1830072334443,-0.312872975277067,0.640449438202247,0.831578947368421,-0.112850082372323,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-0.332,-0.038,"6:5","147/150","N:C:R:F:H:E:Y:Q:W:D:A:S",3.33727355927796,7.45865029764653e-10,0.542113710503027,6.15603976549737,10.8149160259451,96.0464157669383,1.44935953071313,1.80101596312758e-14,13.744482437837,9.60105095933572,112.1508500808,5.67227891121513e-20,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR163958","ERR163958","lineage4.3.4.2.1","mw","Malawi","pnca_p.gln141pro","A","H","GLN","QA141","pnca_complex.pdb"
|
|
"Q141P","L2","PZA","Q","Q141",141,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",8.108,-1.656,0.901,5.02461,-1.835,1.14,79,85,-0.137,6,6,41,0.182222222222222,"helix",-2.9,5.08,0.0019404915912031,28.1422962648557,28.1422937171073,28.1176868093208,83.7298318312042,30,-31,0,0,-31,0,0,0,0,4,2,0,4,0,0,0,0,3,4,-1,-2,-8,0,-10,-6,-0.419452887537994,0.766156462585034,0.1830072334443,-0.312872975277067,0.640449438202247,0.831578947368421,-0.112850082372323,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-0.332,-0.038,"6:5","147/150","N:C:R:F:H:E:Y:Q:W:D:A:S",3.33727355927796,7.45865029764653e-10,0.542113710503027,6.15603976549737,10.8149160259451,96.0464157669383,1.44935953071313,1.80101596312758e-14,13.744482437837,9.60105095933572,112.1508500808,5.67227891121513e-20,"lineage2","dr_mutations_pyrazinamide","PRO",0,"SAMN10961345","SRR8651589","lineage2.2.1","cn","China:Wenzhou","pnca_p.gln141pro","A","H","GLN","QA141","pnca_complex.pdb"
|
|
"Q141P","L1;L4","PZA","Q","Q141",141,"P",0,"MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",8.108,-1.656,0.901,5.02461,-1.835,1.14,79,85,-0.137,6,6,41,0.182222222222222,"helix",-2.9,5.08,0.0019404915912031,28.1422962648557,28.1422937171073,28.1176868093208,83.7298318312042,30,-31,0,0,-31,0,0,0,0,4,2,0,4,0,0,0,0,3,4,-1,-2,-8,0,-10,-6,-0.419452887537994,0.766156462585034,0.1830072334443,-0.312872975277067,0.640449438202247,0.831578947368421,-0.112850082372323,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-0.332,-0.038,"6:5","147/150","N:C:R:F:H:E:Y:Q:W:D:A:S",3.33727355927796,7.45865029764653e-10,0.542113710503027,6.15603976549737,10.8149160259451,96.0464157669383,1.44935953071313,1.80101596312758e-14,13.744482437837,9.60105095933572,112.1508500808,5.67227891121513e-20,"lineage1;lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR176616","ERR176616","lineage4.3.4.2.1;lineage1.1.3","mw","Malawi","pnca_p.gln141pro","A","H","GLN","QA141","pnca_complex.pdb"
|
|
"Q141P","L1;L2","PZA","Q","Q141",141,"P",1,"MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",8.108,-1.656,0.901,5.02461,-1.835,1.14,79,85,-0.137,6,6,41,0.182222222222222,"helix",-2.9,5.08,0.0019404915912031,28.1422962648557,28.1422937171073,28.1176868093208,83.7298318312042,30,-31,0,0,-31,0,0,0,0,4,2,0,4,0,0,0,0,3,4,-1,-2,-8,0,-10,-6,-0.419452887537994,0.766156462585034,0.1830072334443,-0.312872975277067,0.640449438202247,0.831578947368421,-0.112850082372323,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-0.332,-0.038,"6:5","147/150","N:C:R:F:H:E:Y:Q:W:D:A:S",3.33727355927796,7.45865029764653e-10,0.542113710503027,6.15603976549737,10.8149160259451,96.0464157669383,1.44935953071313,1.80101596312758e-14,13.744482437837,9.60105095933572,112.1508500808,5.67227891121513e-20,"lineage1;lineage2","dr_mutations_pyrazinamide","PRO",0,"ERR2516801","ERR2516801","lineage2.2.1;lineage1.1.2","gb","UK","pnca_p.gln141pro","A","H","GLN","QA141","pnca_complex.pdb"
|
|
"Q141P","L4","PZA","Q","Q141",141,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",8.108,-1.656,0.901,5.02461,-1.835,1.14,79,85,-0.137,6,6,41,0.182222222222222,"helix",-2.9,5.08,0.0019404915912031,28.1422962648557,28.1422937171073,28.1176868093208,83.7298318312042,30,-31,0,0,-31,0,0,0,0,4,2,0,4,0,0,0,0,3,4,-1,-2,-8,0,-10,-6,-0.419452887537994,0.766156462585034,0.1830072334443,-0.312872975277067,0.640449438202247,0.831578947368421,-0.112850082372323,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-0.332,-0.038,"6:5","147/150","N:C:R:F:H:E:Y:Q:W:D:A:S",3.33727355927796,7.45865029764653e-10,0.542113710503027,6.15603976549737,10.8149160259451,96.0464157669383,1.44935953071313,1.80101596312758e-14,13.744482437837,9.60105095933572,112.1508500808,5.67227891121513e-20,"lineage4","dr_mutations_pyrazinamide","PRO",0,"7255","ERR3014592","lineage4.6.1.2","","Democratic Republic of the Congo","pnca_p.gln141pro","A","H","GLN","QA141","pnca_complex.pdb"
|
|
"Q141P","L2","PZA","Q","Q141",141,"P",NA,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",8.108,-1.656,0.901,5.02461,-1.835,1.14,79,85,-0.137,6,6,41,0.182222222222222,"helix",-2.9,5.08,0.0019404915912031,28.1422962648557,28.1422937171073,28.1176868093208,83.7298318312042,30,-31,0,0,-31,0,0,0,0,4,2,0,4,0,0,0,0,3,4,-1,-2,-8,0,-10,-6,-0.419452887537994,0.766156462585034,0.1830072334443,-0.312872975277067,0.640449438202247,0.831578947368421,-0.112850082372323,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-0.332,-0.038,"6:5","147/150","N:C:R:F:H:E:Y:Q:W:D:A:S",3.33727355927796,7.45865029764653e-10,0.542113710503027,6.15603976549737,10.8149160259451,96.0464157669383,1.44935953071313,1.80101596312758e-14,13.744482437837,9.60105095933572,112.1508500808,5.67227891121513e-20,"lineage2","dr_mutations_pyrazinamide","PRO",0,"BGI_LN018,SRR671855","SRR671855","lineage2.2.2","cn","China","pnca_p.gln141pro","A","H","GLN","QA141","pnca_complex.pdb"
|
|
"Q141P","L2","PZA","Q","Q141",141,"P",1,"MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",8.108,-1.656,0.901,5.02461,-1.835,1.14,79,85,-0.137,6,6,41,0.182222222222222,"helix",-2.9,5.08,0.0019404915912031,28.1422962648557,28.1422937171073,28.1176868093208,83.7298318312042,30,-31,0,0,-31,0,0,0,0,4,2,0,4,0,0,0,0,3,4,-1,-2,-8,0,-10,-6,-0.419452887537994,0.766156462585034,0.1830072334443,-0.312872975277067,0.640449438202247,0.831578947368421,-0.112850082372323,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-0.332,-0.038,"6:5","147/150","N:C:R:F:H:E:Y:Q:W:D:A:S",3.33727355927796,7.45865029764653e-10,0.542113710503027,6.15603976549737,10.8149160259451,96.0464157669383,1.44935953071313,1.80101596312758e-14,13.744482437837,9.60105095933572,112.1508500808,5.67227891121513e-20,"lineage2","dr_mutations_pyrazinamide","PRO",0,"SAMEA2533838,ERS457240,ERR551290","ERR551290","lineage2.2.1","uz","Nukus","pnca_p.gln141pro","A","H","GLN","QA141","pnca_complex.pdb"
|
|
"Q141P","L4","PZA","Q","Q141",141,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",8.108,-1.656,0.901,5.02461,-1.835,1.14,79,85,-0.137,6,6,41,0.182222222222222,"helix",-2.9,5.08,0.0019404915912031,28.1422962648557,28.1422937171073,28.1176868093208,83.7298318312042,30,-31,0,0,-31,0,0,0,0,4,2,0,4,0,0,0,0,3,4,-1,-2,-8,0,-10,-6,-0.419452887537994,0.766156462585034,0.1830072334443,-0.312872975277067,0.640449438202247,0.831578947368421,-0.112850082372323,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-0.332,-0.038,"6:5","147/150","N:C:R:F:H:E:Y:Q:W:D:A:S",3.33727355927796,7.45865029764653e-10,0.542113710503027,6.15603976549737,10.8149160259451,96.0464157669383,1.44935953071313,1.80101596312758e-14,13.744482437837,9.60105095933572,112.1508500808,5.67227891121513e-20,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERS457670,SAMEA2534268","ERR551887_ERR551888","lineage4.8","uz","Nukus","pnca_p.gln141pro","A","H","GLN","QA141","pnca_complex.pdb"
|
|
"Q141P","L3","PZA","Q","Q141",141,"P",NA,"MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",8.108,-1.656,0.901,5.02461,-1.835,1.14,79,85,-0.137,6,6,41,0.182222222222222,"helix",-2.9,5.08,0.0019404915912031,28.1422962648557,28.1422937171073,28.1176868093208,83.7298318312042,30,-31,0,0,-31,0,0,0,0,4,2,0,4,0,0,0,0,3,4,-1,-2,-8,0,-10,-6,-0.419452887537994,0.766156462585034,0.1830072334443,-0.312872975277067,0.640449438202247,0.831578947368421,-0.112850082372323,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-0.332,-0.038,"6:5","147/150","N:C:R:F:H:E:Y:Q:W:D:A:S",3.33727355927796,7.45865029764653e-10,0.542113710503027,6.15603976549737,10.8149160259451,96.0464157669383,1.44935953071313,1.80101596312758e-14,13.744482437837,9.60105095933572,112.1508500808,5.67227891121513e-20,"lineage3","dr_mutations_pyrazinamide","PRO",0,"ERR2516883","ERR2516883","lineage3","gb","UK","pnca_p.gln141pro","A","H","GLN","QA141","pnca_complex.pdb"
|
|
"Q141P","L2","PZA","Q","Q141",141,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",8.108,-1.656,0.901,5.02461,-1.835,1.14,79,85,-0.137,6,6,41,0.182222222222222,"helix",-2.9,5.08,0.0019404915912031,28.1422962648557,28.1422937171073,28.1176868093208,83.7298318312042,30,-31,0,0,-31,0,0,0,0,4,2,0,4,0,0,0,0,3,4,-1,-2,-8,0,-10,-6,-0.419452887537994,0.766156462585034,0.1830072334443,-0.312872975277067,0.640449438202247,0.831578947368421,-0.112850082372323,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-0.332,-0.038,"6:5","147/150","N:C:R:F:H:E:Y:Q:W:D:A:S",3.33727355927796,7.45865029764653e-10,0.542113710503027,6.15603976549737,10.8149160259451,96.0464157669383,1.44935953071313,1.80101596312758e-14,13.744482437837,9.60105095933572,112.1508500808,5.67227891121513e-20,"lineage2","dr_mutations_pyrazinamide","PRO",0,"ERS458375","ERR552873_ERR552872_ERR552874","lineage2.2.1","uz","Nukus","pnca_p.gln141pro","A","H","GLN","QA141","pnca_complex.pdb"
|
|
"Q141P","L4","PZA","Q","Q141",141,"P",1,"MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",8.108,-1.656,0.901,5.02461,-1.835,1.14,79,85,-0.137,6,6,41,0.182222222222222,"helix",-2.9,5.08,0.0019404915912031,28.1422962648557,28.1422937171073,28.1176868093208,83.7298318312042,30,-31,0,0,-31,0,0,0,0,4,2,0,4,0,0,0,0,3,4,-1,-2,-8,0,-10,-6,-0.419452887537994,0.766156462585034,0.1830072334443,-0.312872975277067,0.640449438202247,0.831578947368421,-0.112850082372323,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-0.332,-0.038,"6:5","147/150","N:C:R:F:H:E:Y:Q:W:D:A:S",3.33727355927796,7.45865029764653e-10,0.542113710503027,6.15603976549737,10.8149160259451,96.0464157669383,1.44935953071313,1.80101596312758e-14,13.744482437837,9.60105095933572,112.1508500808,5.67227891121513e-20,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR037486","ERR037486","lineage4.3.4.2.1","mw","Malawi","pnca_p.gln141pro","A","H","GLN","QA141","pnca_complex.pdb"
|
|
"Q141P","L4","PZA","Q","Q141",141,"P",NA,"MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",8.108,-1.656,0.901,5.02461,-1.835,1.14,79,85,-0.137,6,6,41,0.182222222222222,"helix",-2.9,5.08,0.0019404915912031,28.1422962648557,28.1422937171073,28.1176868093208,83.7298318312042,30,-31,0,0,-31,0,0,0,0,4,2,0,4,0,0,0,0,3,4,-1,-2,-8,0,-10,-6,-0.419452887537994,0.766156462585034,0.1830072334443,-0.312872975277067,0.640449438202247,0.831578947368421,-0.112850082372323,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-0.332,-0.038,"6:5","147/150","N:C:R:F:H:E:Y:Q:W:D:A:S",3.33727355927796,7.45865029764653e-10,0.542113710503027,6.15603976549737,10.8149160259451,96.0464157669383,1.44935953071313,1.80101596312758e-14,13.744482437837,9.60105095933572,112.1508500808,5.67227891121513e-20,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR221618","ERR221618","lineage4.3.4.2.1","mw","Malawi","pnca_p.gln141pro","A","H","GLN","QA141","pnca_complex.pdb"
|
|
"Q141P","L2","PZA","Q","Q141",141,"P",NA,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",8.108,-1.656,0.901,5.02461,-1.835,1.14,79,85,-0.137,6,6,41,0.182222222222222,"helix",-2.9,5.08,0.0019404915912031,28.1422962648557,28.1422937171073,28.1176868093208,83.7298318312042,30,-31,0,0,-31,0,0,0,0,4,2,0,4,0,0,0,0,3,4,-1,-2,-8,0,-10,-6,-0.419452887537994,0.766156462585034,0.1830072334443,-0.312872975277067,0.640449438202247,0.831578947368421,-0.112850082372323,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-0.332,-0.038,"6:5","147/150","N:C:R:F:H:E:Y:Q:W:D:A:S",3.33727355927796,7.45865029764653e-10,0.542113710503027,6.15603976549737,10.8149160259451,96.0464157669383,1.44935953071313,1.80101596312758e-14,13.744482437837,9.60105095933572,112.1508500808,5.67227891121513e-20,"lineage2","dr_mutations_pyrazinamide","PRO",0,"ETB0052","SRR6257101","lineage2.2.1","ru","Russia:Leningrad Region","pnca_p.gln141pro","A","H","GLN","QA141","pnca_complex.pdb"
|
|
"Q141P","L5","PZA","Q","Q141",141,"P",NA,"MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",8.108,-1.656,0.901,5.02461,-1.835,1.14,79,85,-0.137,6,6,41,0.182222222222222,"helix",-2.9,5.08,0.0019404915912031,28.1422962648557,28.1422937171073,28.1176868093208,83.7298318312042,30,-31,0,0,-31,0,0,0,0,4,2,0,4,0,0,0,0,3,4,-1,-2,-8,0,-10,-6,-0.419452887537994,0.766156462585034,0.1830072334443,-0.312872975277067,0.640449438202247,0.831578947368421,-0.112850082372323,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-0.332,-0.038,"6:5","147/150","N:C:R:F:H:E:Y:Q:W:D:A:S",3.33727355927796,7.45865029764653e-10,0.542113710503027,6.15603976549737,10.8149160259451,96.0464157669383,1.44935953071313,1.80101596312758e-14,13.744482437837,9.60105095933572,112.1508500808,5.67227891121513e-20,"lineage5","dr_mutations_pyrazinamide","PRO",0,"ERR751313","ERR751313","lineage5","gh","Ghana","pnca_p.gln141pro","A","H","GLN","QA141","pnca_complex.pdb"
|
|
"Q141P","L4","PZA","Q","Q141",141,"P",NA,"MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",8.108,-1.656,0.901,5.02461,-1.835,1.14,79,85,-0.137,6,6,41,0.182222222222222,"helix",-2.9,5.08,0.0019404915912031,28.1422962648557,28.1422937171073,28.1176868093208,83.7298318312042,30,-31,0,0,-31,0,0,0,0,4,2,0,4,0,0,0,0,3,4,-1,-2,-8,0,-10,-6,-0.419452887537994,0.766156462585034,0.1830072334443,-0.312872975277067,0.640449438202247,0.831578947368421,-0.112850082372323,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-0.332,-0.038,"6:5","147/150","N:C:R:F:H:E:Y:Q:W:D:A:S",3.33727355927796,7.45865029764653e-10,0.542113710503027,6.15603976549737,10.8149160259451,96.0464157669383,1.44935953071313,1.80101596312758e-14,13.744482437837,9.60105095933572,112.1508500808,5.67227891121513e-20,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR2707132","ERR2707132","lineage4.6.1.2","cd","Democratic Republic of Congo","pnca_p.gln141pro","A","H","GLN","QA141","pnca_complex.pdb"
|
|
"Q141P","L3","PZA","Q","Q141",141,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",8.108,-1.656,0.901,5.02461,-1.835,1.14,79,85,-0.137,6,6,41,0.182222222222222,"helix",-2.9,5.08,0.0019404915912031,28.1422962648557,28.1422937171073,28.1176868093208,83.7298318312042,30,-31,0,0,-31,0,0,0,0,4,2,0,4,0,0,0,0,3,4,-1,-2,-8,0,-10,-6,-0.419452887537994,0.766156462585034,0.1830072334443,-0.312872975277067,0.640449438202247,0.831578947368421,-0.112850082372323,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-0.332,-0.038,"6:5","147/150","N:C:R:F:H:E:Y:Q:W:D:A:S",3.33727355927796,7.45865029764653e-10,0.542113710503027,6.15603976549737,10.8149160259451,96.0464157669383,1.44935953071313,1.80101596312758e-14,13.744482437837,9.60105095933572,112.1508500808,5.67227891121513e-20,"lineage3","dr_mutations_pyrazinamide","PRO",0,"ERR2510441","ERR2510441","lineage3","pk","Pakistan","pnca_p.gln141pro","A","H","GLN","QA141","pnca_complex.pdb"
|
|
"Q141P","L2","PZA","Q","Q141",141,"P",NA,"MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",8.108,-1.656,0.901,5.02461,-1.835,1.14,79,85,-0.137,6,6,41,0.182222222222222,"helix",-2.9,5.08,0.0019404915912031,28.1422962648557,28.1422937171073,28.1176868093208,83.7298318312042,30,-31,0,0,-31,0,0,0,0,4,2,0,4,0,0,0,0,3,4,-1,-2,-8,0,-10,-6,-0.419452887537994,0.766156462585034,0.1830072334443,-0.312872975277067,0.640449438202247,0.831578947368421,-0.112850082372323,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-0.332,-0.038,"6:5","147/150","N:C:R:F:H:E:Y:Q:W:D:A:S",3.33727355927796,7.45865029764653e-10,0.542113710503027,6.15603976549737,10.8149160259451,96.0464157669383,1.44935953071313,1.80101596312758e-14,13.744482437837,9.60105095933572,112.1508500808,5.67227891121513e-20,"lineage2","dr_mutations_pyrazinamide","PRO",0,"ERR1036287","ERR1036287","lineage2.2.1","pt","Portugal","pnca_p.gln141pro","A","H","GLN","QA141","pnca_complex.pdb"
|
|
"Q141P","L2","PZA","Q","Q141",141,"P",1,"MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",8.108,-1.656,0.901,5.02461,-1.835,1.14,79,85,-0.137,6,6,41,0.182222222222222,"helix",-2.9,5.08,0.0019404915912031,28.1422962648557,28.1422937171073,28.1176868093208,83.7298318312042,30,-31,0,0,-31,0,0,0,0,4,2,0,4,0,0,0,0,3,4,-1,-2,-8,0,-10,-6,-0.419452887537994,0.766156462585034,0.1830072334443,-0.312872975277067,0.640449438202247,0.831578947368421,-0.112850082372323,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-0.332,-0.038,"6:5","147/150","N:C:R:F:H:E:Y:Q:W:D:A:S",3.33727355927796,7.45865029764653e-10,0.542113710503027,6.15603976549737,10.8149160259451,96.0464157669383,1.44935953071313,1.80101596312758e-14,13.744482437837,9.60105095933572,112.1508500808,5.67227891121513e-20,"lineage2","dr_mutations_pyrazinamide","PRO",0,"ERR2516784","ERR2516784","lineage2.2.1","gb","UK","pnca_p.gln141pro","A","H","GLN","QA141","pnca_complex.pdb"
|
|
"Q141R","L4","PZA","Q","Q141",141,"R",0,"Sensitive","OM","hydrophilic","hydrophilic","neutral","basic","polar","pos",8.108,-1.581,0.765,1.88305,-0.131,0.13,36,66,-0.137,6,6,41,0.182222222222222,"helix",-2.9,5.08,0.0001437401178668,1.2119588062211,4.59700131334267e-05,0,1.01056822389159e-25,-58,-30,0,0,-30,0,0,0,0,4,0,0,4,0,0,0,0,-3,0,1,-5,0,0,0,0,-0.400455927051672,0.650510204081633,0.068584779900786,-0.0223358908780904,0.0730337078651685,0.378947368421053,-0.112850082372323,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-0.332,-0.038,"6:5","147/150","N:C:R:F:H:E:Y:Q:W:D:A:S",-9.98752126245058,0.942832958100734,139.277183325398,-0.0717096729269461,NA,144471.706314847,0.0834878586628579,1,0,0,25.8386585962163,0.999999999999746,"lineage4","other_mutations_pyrazinamide","ARG",0,"ERR2510802","ERR2510802","lineage4.1.2.1","it","Italy","pnca_p.gln141arg","A","H","GLN","QA141","pnca_complex.pdb"
|
|
"Q141R","L4","PZA","Q","Q141",141,"R",NA,"Pre-MDR","OM","hydrophilic","hydrophilic","neutral","basic","polar","pos",8.108,-1.581,0.765,1.88305,-0.131,0.13,36,66,-0.137,6,6,41,0.182222222222222,"helix",-2.9,5.08,0.0001437401178668,1.2119588062211,4.59700131334267e-05,0,1.01056822389159e-25,-58,-30,0,0,-30,0,0,0,0,4,0,0,4,0,0,0,0,-3,0,1,-5,0,0,0,0,-0.400455927051672,0.650510204081633,0.068584779900786,-0.0223358908780904,0.0730337078651685,0.378947368421053,-0.112850082372323,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-0.332,-0.038,"6:5","147/150","N:C:R:F:H:E:Y:Q:W:D:A:S",-9.98752126245058,0.942832958100734,139.277183325398,-0.0717096729269461,NA,144471.706314847,0.0834878586628579,1,0,0,25.8386585962163,0.999999999999746,"lineage4","other_mutations_pyrazinamide","ARG",0,"SRR6325445","SRR6325445","lineage4.3","us","","pnca_p.gln141arg","A","H","GLN","QA141","pnca_complex.pdb"
|
|
"Q141R","","PZA","Q","Q141",141,"R",0,"Pre-MDR","OM","hydrophilic","hydrophilic","neutral","basic","polar","pos",8.108,-1.581,0.765,1.88305,-0.131,0.13,36,66,-0.137,6,6,41,0.182222222222222,"helix",-2.9,5.08,0.0001437401178668,1.2119588062211,4.59700131334267e-05,0,1.01056822389159e-25,-58,-30,0,0,-30,0,0,0,0,4,0,0,4,0,0,0,0,-3,0,1,-5,0,0,0,0,-0.400455927051672,0.650510204081633,0.068584779900786,-0.0223358908780904,0.0730337078651685,0.378947368421053,-0.112850082372323,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-0.332,-0.038,"6:5","147/150","N:C:R:F:H:E:Y:Q:W:D:A:S",-9.98752126245058,0.942832958100734,139.277183325398,-0.0717096729269461,NA,144471.706314847,0.0834878586628579,1,0,0,25.8386585962163,0.999999999999746,"","other_mutations_pyrazinamide","ARG",0,"ERR1035239","ERR1035239","","pt","Portugal","pnca_p.gln141arg","A","H","GLN","QA141","pnca_complex.pdb"
|
|
"Q141R","L4","PZA","Q","Q141",141,"R",NA,"Pre-MDR","OM","hydrophilic","hydrophilic","neutral","basic","polar","pos",8.108,-1.581,0.765,1.88305,-0.131,0.13,36,66,-0.137,6,6,41,0.182222222222222,"helix",-2.9,5.08,0.0001437401178668,1.2119588062211,4.59700131334267e-05,0,1.01056822389159e-25,-58,-30,0,0,-30,0,0,0,0,4,0,0,4,0,0,0,0,-3,0,1,-5,0,0,0,0,-0.400455927051672,0.650510204081633,0.068584779900786,-0.0223358908780904,0.0730337078651685,0.378947368421053,-0.112850082372323,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-0.332,-0.038,"6:5","147/150","N:C:R:F:H:E:Y:Q:W:D:A:S",-9.98752126245058,0.942832958100734,139.277183325398,-0.0717096729269461,NA,144471.706314847,0.0834878586628579,1,0,0,25.8386585962163,0.999999999999746,"lineage4","other_mutations_pyrazinamide","ARG",0,"SRR6325448","SRR6325448","lineage4.3","us","","pnca_p.gln141arg","A","H","GLN","QA141","pnca_complex.pdb"
|
|
"Q141R","L3;L4","PZA","Q","Q141",141,"R",NA,"Pre-MDR","OM","hydrophilic","hydrophilic","neutral","basic","polar","pos",8.108,-1.581,0.765,1.88305,-0.131,0.13,36,66,-0.137,6,6,41,0.182222222222222,"helix",-2.9,5.08,0.0001437401178668,1.2119588062211,4.59700131334267e-05,0,1.01056822389159e-25,-58,-30,0,0,-30,0,0,0,0,4,0,0,4,0,0,0,0,-3,0,1,-5,0,0,0,0,-0.400455927051672,0.650510204081633,0.068584779900786,-0.0223358908780904,0.0730337078651685,0.378947368421053,-0.112850082372323,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",-0.332,-0.038,"6:5","147/150","N:C:R:F:H:E:Y:Q:W:D:A:S",-9.98752126245058,0.942832958100734,139.277183325398,-0.0717096729269461,NA,144471.706314847,0.0834878586628579,1,0,0,25.8386585962163,0.999999999999746,"lineage3;lineage4","other_mutations_pyrazinamide","ARG",0,"SRR6325444","SRR6325444","lineage4.3;lineage3","us","","pnca_p.gln141arg","A","H","GLN","QA141","pnca_complex.pdb"
|
|
"T142A","L4","PZA","T","T142",142,"A",1,"MDR","DM","hydrophobic","hydrophobic","neutral","non-polar","polar","non-polar",8.098,-1.983,-0.572,2.85915,-2.289,-0.73,80,91,-0.892,8,8,0,0,"helix",-0.8,8.33,0.0005749604714675,14.5802781289507,14.5802277940117,14.5801759034061,15.0663448164144,4,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,4,0,4,0,6,0,2,9,-0.502279635258359,-0.147803617571059,0.104136466611791,-0.390281329923274,-0.19109947643979,0.842105263157895,-0.734761120263591,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","147/150","S:E:T",2.6796663501904,0.0010245352377103,0.816050632122411,3.28370108999369,3.35697961122189,99.5538692592404,1.16376580853041,0.0005075351447614,3.29453387923245,2.60435121163486,147.676327006136,0.0001037975122989,"lineage4","dr_mutations_pyrazinamide","ALA",0,"364","ERR3014580","lineage4.8","tn","Tunisia:Sousse","pnca_p.thr142ala","A","H","THR","TA142","pnca_complex.pdb"
|
|
"T142A","L2","PZA","T","T142",142,"A",0,"MDR","DM","hydrophobic","hydrophobic","neutral","non-polar","polar","non-polar",8.098,-1.983,-0.572,2.85915,-2.289,-0.73,80,91,-0.892,8,8,0,0,"helix",-0.8,8.33,0.0005749604714675,14.5802781289507,14.5802277940117,14.5801759034061,15.0663448164144,4,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,4,0,4,0,6,0,2,9,-0.502279635258359,-0.147803617571059,0.104136466611791,-0.390281329923274,-0.19109947643979,0.842105263157895,-0.734761120263591,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","147/150","S:E:T",2.6796663501904,0.0010245352377103,0.816050632122411,3.28370108999369,3.35697961122189,99.5538692592404,1.16376580853041,0.0005075351447614,3.29453387923245,2.60435121163486,147.676327006136,0.0001037975122989,"lineage2","dr_mutations_pyrazinamide","ALA",0,"MDR_5102","SRR6824648","lineage2.2.1","cn","China: Huimin District, Huhhot City, Inner Mongolia Province","pnca_p.thr142ala","A","H","THR","TA142","pnca_complex.pdb"
|
|
"T142A","L2","PZA","T","T142",142,"A",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","neutral","non-polar","polar","non-polar",8.098,-1.983,-0.572,2.85915,-2.289,-0.73,80,91,-0.892,8,8,0,0,"helix",-0.8,8.33,0.0005749604714675,14.5802781289507,14.5802277940117,14.5801759034061,15.0663448164144,4,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,4,0,4,0,6,0,2,9,-0.502279635258359,-0.147803617571059,0.104136466611791,-0.390281329923274,-0.19109947643979,0.842105263157895,-0.734761120263591,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","147/150","S:E:T",2.6796663501904,0.0010245352377103,0.816050632122411,3.28370108999369,3.35697961122189,99.5538692592404,1.16376580853041,0.0005075351447614,3.29453387923245,2.60435121163486,147.676327006136,0.0001037975122989,"lineage2","dr_mutations_pyrazinamide","ALA",0,"ERR502927","ERR502927","lineage2.2.1","","","pnca_p.thr142ala","A","H","THR","TA142","pnca_complex.pdb"
|
|
"T142A","L2","PZA","T","T142",142,"A",1,"MDR","DM","hydrophobic","hydrophobic","neutral","non-polar","polar","non-polar",8.098,-1.983,-0.572,2.85915,-2.289,-0.73,80,91,-0.892,8,8,0,0,"helix",-0.8,8.33,0.0005749604714675,14.5802781289507,14.5802277940117,14.5801759034061,15.0663448164144,4,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,4,0,4,0,6,0,2,9,-0.502279635258359,-0.147803617571059,0.104136466611791,-0.390281329923274,-0.19109947643979,0.842105263157895,-0.734761120263591,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","147/150","S:E:T",2.6796663501904,0.0010245352377103,0.816050632122411,3.28370108999369,3.35697961122189,99.5538692592404,1.16376580853041,0.0005075351447614,3.29453387923245,2.60435121163486,147.676327006136,0.0001037975122989,"lineage2","dr_mutations_pyrazinamide","ALA",0,"ERR2516978","ERR2516978","lineage2.2.1","gb","UK","pnca_p.thr142ala","A","H","THR","TA142","pnca_complex.pdb"
|
|
"T142A","L2","PZA","T","T142",142,"A",NA,"MDR","DM","hydrophobic","hydrophobic","neutral","non-polar","polar","non-polar",8.098,-1.983,-0.572,2.85915,-2.289,-0.73,80,91,-0.892,8,8,0,0,"helix",-0.8,8.33,0.0005749604714675,14.5802781289507,14.5802277940117,14.5801759034061,15.0663448164144,4,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,4,0,4,0,6,0,2,9,-0.502279635258359,-0.147803617571059,0.104136466611791,-0.390281329923274,-0.19109947643979,0.842105263157895,-0.734761120263591,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","147/150","S:E:T",2.6796663501904,0.0010245352377103,0.816050632122411,3.28370108999369,3.35697961122189,99.5538692592404,1.16376580853041,0.0005075351447614,3.29453387923245,2.60435121163486,147.676327006136,0.0001037975122989,"lineage2","dr_mutations_pyrazinamide","ALA",0,"SRS797129","SRR1723639","lineage2.2.1","cn","China:InnerMongolia","pnca_p.thr142ala","A","H","THR","TA142","pnca_complex.pdb"
|
|
"T142A","L2","PZA","T","T142",142,"A",NA,"Pre-MDR","DM","hydrophobic","hydrophobic","neutral","non-polar","polar","non-polar",8.098,-1.983,-0.572,2.85915,-2.289,-0.73,80,91,-0.892,8,8,0,0,"helix",-0.8,8.33,0.0005749604714675,14.5802781289507,14.5802277940117,14.5801759034061,15.0663448164144,4,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,4,0,4,0,6,0,2,9,-0.502279635258359,-0.147803617571059,0.104136466611791,-0.390281329923274,-0.19109947643979,0.842105263157895,-0.734761120263591,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","147/150","S:E:T",2.6796663501904,0.0010245352377103,0.816050632122411,3.28370108999369,3.35697961122189,99.5538692592404,1.16376580853041,0.0005075351447614,3.29453387923245,2.60435121163486,147.676327006136,0.0001037975122989,"lineage2","dr_mutations_pyrazinamide","ALA",0,"SRR5709892,SAMN07236519","SRR5709892","lineage2.2.1.1","th","Thailand","pnca_p.thr142ala","A","H","THR","TA142","pnca_complex.pdb"
|
|
"T142A","L2","PZA","T","T142",142,"A",1,"Pre-XDR","DM","hydrophobic","hydrophobic","neutral","non-polar","polar","non-polar",8.098,-1.983,-0.572,2.85915,-2.289,-0.73,80,91,-0.892,8,8,0,0,"helix",-0.8,8.33,0.0005749604714675,14.5802781289507,14.5802277940117,14.5801759034061,15.0663448164144,4,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,4,0,4,0,6,0,2,9,-0.502279635258359,-0.147803617571059,0.104136466611791,-0.390281329923274,-0.19109947643979,0.842105263157895,-0.734761120263591,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","147/150","S:E:T",2.6796663501904,0.0010245352377103,0.816050632122411,3.28370108999369,3.35697961122189,99.5538692592404,1.16376580853041,0.0005075351447614,3.29453387923245,2.60435121163486,147.676327006136,0.0001037975122989,"lineage2","dr_mutations_pyrazinamide","ALA",0,"SAMN10961358","SRR8651599","lineage2.2.1","cn","China:Wenzhou","pnca_p.thr142ala","A","H","THR","TA142","pnca_complex.pdb"
|
|
"T142A","L2","PZA","T","T142",142,"A",1,"Pre-XDR","DM","hydrophobic","hydrophobic","neutral","non-polar","polar","non-polar",8.098,-1.983,-0.572,2.85915,-2.289,-0.73,80,91,-0.892,8,8,0,0,"helix",-0.8,8.33,0.0005749604714675,14.5802781289507,14.5802277940117,14.5801759034061,15.0663448164144,4,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,4,0,4,0,6,0,2,9,-0.502279635258359,-0.147803617571059,0.104136466611791,-0.390281329923274,-0.19109947643979,0.842105263157895,-0.734761120263591,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","147/150","S:E:T",2.6796663501904,0.0010245352377103,0.816050632122411,3.28370108999369,3.35697961122189,99.5538692592404,1.16376580853041,0.0005075351447614,3.29453387923245,2.60435121163486,147.676327006136,0.0001037975122989,"lineage2","dr_mutations_pyrazinamide","ALA",0,"ERR2516697","ERR2516697","lineage2.2.1","pe","Peru","pnca_p.thr142ala","A","H","THR","TA142","pnca_complex.pdb"
|
|
"T142A","L3","PZA","T","T142",142,"A",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","neutral","non-polar","polar","non-polar",8.098,-1.983,-0.572,2.85915,-2.289,-0.73,80,91,-0.892,8,8,0,0,"helix",-0.8,8.33,0.0005749604714675,14.5802781289507,14.5802277940117,14.5801759034061,15.0663448164144,4,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,4,0,4,0,6,0,2,9,-0.502279635258359,-0.147803617571059,0.104136466611791,-0.390281329923274,-0.19109947643979,0.842105263157895,-0.734761120263591,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","147/150","S:E:T",2.6796663501904,0.0010245352377103,0.816050632122411,3.28370108999369,3.35697961122189,99.5538692592404,1.16376580853041,0.0005075351447614,3.29453387923245,2.60435121163486,147.676327006136,0.0001037975122989,"lineage3","dr_mutations_pyrazinamide","ALA",0,"ERR3335741","ERR3335741","lineage3","pk","Pakistan","pnca_p.thr142ala","A","H","THR","TA142","pnca_complex.pdb"
|
|
"T142A","L2","PZA","T","T142",142,"A",0,"MDR","DM","hydrophobic","hydrophobic","neutral","non-polar","polar","non-polar",8.098,-1.983,-0.572,2.85915,-2.289,-0.73,80,91,-0.892,8,8,0,0,"helix",-0.8,8.33,0.0005749604714675,14.5802781289507,14.5802277940117,14.5801759034061,15.0663448164144,4,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,4,0,4,0,6,0,2,9,-0.502279635258359,-0.147803617571059,0.104136466611791,-0.390281329923274,-0.19109947643979,0.842105263157895,-0.734761120263591,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","147/150","S:E:T",2.6796663501904,0.0010245352377103,0.816050632122411,3.28370108999369,3.35697961122189,99.5538692592404,1.16376580853041,0.0005075351447614,3.29453387923245,2.60435121163486,147.676327006136,0.0001037975122989,"lineage2","dr_mutations_pyrazinamide","ALA",0,"MDR_5105","SRR6824655","lineage2.2.1","cn","China: Huimin District, Huhhot City, Inner Mongolia Province","pnca_p.thr142ala","A","H","THR","TA142","pnca_complex.pdb"
|
|
"T142A","L2","PZA","T","T142",142,"A",NA,"XDR","DM","hydrophobic","hydrophobic","neutral","non-polar","polar","non-polar",8.098,-1.983,-0.572,2.85915,-2.289,-0.73,80,91,-0.892,8,8,0,0,"helix",-0.8,8.33,0.0005749604714675,14.5802781289507,14.5802277940117,14.5801759034061,15.0663448164144,4,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,4,0,4,0,6,0,2,9,-0.502279635258359,-0.147803617571059,0.104136466611791,-0.390281329923274,-0.19109947643979,0.842105263157895,-0.734761120263591,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","147/150","S:E:T",2.6796663501904,0.0010245352377103,0.816050632122411,3.28370108999369,3.35697961122189,99.5538692592404,1.16376580853041,0.0005075351447614,3.29453387923245,2.60435121163486,147.676327006136,0.0001037975122989,"lineage2","dr_mutations_pyrazinamide","ALA",0,"ERR775382","ERR775382","lineage2.2.1","pe","","pnca_p.thr142ala","A","H","THR","TA142","pnca_complex.pdb"
|
|
"T142A","L4","PZA","T","T142",142,"A",NA,"MDR","DM","hydrophobic","hydrophobic","neutral","non-polar","polar","non-polar",8.098,-1.983,-0.572,2.85915,-2.289,-0.73,80,91,-0.892,8,8,0,0,"helix",-0.8,8.33,0.0005749604714675,14.5802781289507,14.5802277940117,14.5801759034061,15.0663448164144,4,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,4,0,4,0,6,0,2,9,-0.502279635258359,-0.147803617571059,0.104136466611791,-0.390281329923274,-0.19109947643979,0.842105263157895,-0.734761120263591,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","147/150","S:E:T",2.6796663501904,0.0010245352377103,0.816050632122411,3.28370108999369,3.35697961122189,99.5538692592404,1.16376580853041,0.0005075351447614,3.29453387923245,2.60435121163486,147.676327006136,0.0001037975122989,"lineage4","dr_mutations_pyrazinamide","ALA",0,"ERR2707051","ERR2707051","lineage4.6.1.2","cd","Democratic Republic of Congo","pnca_p.thr142ala","A","H","THR","TA142","pnca_complex.pdb"
|
|
"T142A","L2","PZA","T","T142",142,"A",NA,"MDR","DM","hydrophobic","hydrophobic","neutral","non-polar","polar","non-polar",8.098,-1.983,-0.572,2.85915,-2.289,-0.73,80,91,-0.892,8,8,0,0,"helix",-0.8,8.33,0.0005749604714675,14.5802781289507,14.5802277940117,14.5801759034061,15.0663448164144,4,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,4,0,4,0,6,0,2,9,-0.502279635258359,-0.147803617571059,0.104136466611791,-0.390281329923274,-0.19109947643979,0.842105263157895,-0.734761120263591,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","147/150","S:E:T",2.6796663501904,0.0010245352377103,0.816050632122411,3.28370108999369,3.35697961122189,99.5538692592404,1.16376580853041,0.0005075351447614,3.29453387923245,2.60435121163486,147.676327006136,0.0001037975122989,"lineage2","dr_mutations_pyrazinamide","ALA",0,"SRS797130","SRR1723640","lineage2.2.1","cn","China:InnerMongolia","pnca_p.thr142ala","A","H","THR","TA142","pnca_complex.pdb"
|
|
"T142A","L4","PZA","T","T142",142,"A",NA,"MDR","DM","hydrophobic","hydrophobic","neutral","non-polar","polar","non-polar",8.098,-1.983,-0.572,2.85915,-2.289,-0.73,80,91,-0.892,8,8,0,0,"helix",-0.8,8.33,0.0005749604714675,14.5802781289507,14.5802277940117,14.5801759034061,15.0663448164144,4,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,4,0,4,0,6,0,2,9,-0.502279635258359,-0.147803617571059,0.104136466611791,-0.390281329923274,-0.19109947643979,0.842105263157895,-0.734761120263591,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","147/150","S:E:T",2.6796663501904,0.0010245352377103,0.816050632122411,3.28370108999369,3.35697961122189,99.5538692592404,1.16376580853041,0.0005075351447614,3.29453387923245,2.60435121163486,147.676327006136,0.0001037975122989,"lineage4","dr_mutations_pyrazinamide","ALA",0,"ERR779919","ERR779919","lineage4.1.1","pe","","pnca_p.thr142ala","A","H","THR","TA142","pnca_complex.pdb"
|
|
"T142A","L4","PZA","T","T142",142,"A",NA,"MDR","DM","hydrophobic","hydrophobic","neutral","non-polar","polar","non-polar",8.098,-1.983,-0.572,2.85915,-2.289,-0.73,80,91,-0.892,8,8,0,0,"helix",-0.8,8.33,0.0005749604714675,14.5802781289507,14.5802277940117,14.5801759034061,15.0663448164144,4,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,4,0,4,0,6,0,2,9,-0.502279635258359,-0.147803617571059,0.104136466611791,-0.390281329923274,-0.19109947643979,0.842105263157895,-0.734761120263591,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","147/150","S:E:T",2.6796663501904,0.0010245352377103,0.816050632122411,3.28370108999369,3.35697961122189,99.5538692592404,1.16376580853041,0.0005075351447614,3.29453387923245,2.60435121163486,147.676327006136,0.0001037975122989,"lineage4","dr_mutations_pyrazinamide","ALA",0,"ERR1199106","ERR1199106","lineage4.6.1.2","cd","Democratic Republic of the Congo","pnca_p.thr142ala","A","H","THR","TA142","pnca_complex.pdb"
|
|
"T142A","L2","PZA","T","T142",142,"A",1,"MDR","DM","hydrophobic","hydrophobic","neutral","non-polar","polar","non-polar",8.098,-1.983,-0.572,2.85915,-2.289,-0.73,80,91,-0.892,8,8,0,0,"helix",-0.8,8.33,0.0005749604714675,14.5802781289507,14.5802277940117,14.5801759034061,15.0663448164144,4,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,4,0,4,0,6,0,2,9,-0.502279635258359,-0.147803617571059,0.104136466611791,-0.390281329923274,-0.19109947643979,0.842105263157895,-0.734761120263591,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","147/150","S:E:T",2.6796663501904,0.0010245352377103,0.816050632122411,3.28370108999369,3.35697961122189,99.5538692592404,1.16376580853041,0.0005075351447614,3.29453387923245,2.60435121163486,147.676327006136,0.0001037975122989,"lineage2","dr_mutations_pyrazinamide","ALA",0,"ERR2516845","ERR2516845","lineage2.2.1","gb","UK","pnca_p.thr142ala","A","H","THR","TA142","pnca_complex.pdb"
|
|
"T142A","L4","PZA","T","T142",142,"A",1,"MDR","DM","hydrophobic","hydrophobic","neutral","non-polar","polar","non-polar",8.098,-1.983,-0.572,2.85915,-2.289,-0.73,80,91,-0.892,8,8,0,0,"helix",-0.8,8.33,0.0005749604714675,14.5802781289507,14.5802277940117,14.5801759034061,15.0663448164144,4,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,4,0,4,0,6,0,2,9,-0.502279635258359,-0.147803617571059,0.104136466611791,-0.390281329923274,-0.19109947643979,0.842105263157895,-0.734761120263591,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","147/150","S:E:T",2.6796663501904,0.0010245352377103,0.816050632122411,3.28370108999369,3.35697961122189,99.5538692592404,1.16376580853041,0.0005075351447614,3.29453387923245,2.60435121163486,147.676327006136,0.0001037975122989,"lineage4","dr_mutations_pyrazinamide","ALA",0,"ERR2516517","ERR2516517","lineage4.1.1","pe","Peru","pnca_p.thr142ala","A","H","THR","TA142","pnca_complex.pdb"
|
|
"T142K","L6","PZA","T","T142",142,"K",1,"MDR","DM","hydrophobic","hydrophobic","neutral","basic","polar","pos",8.098,-1.238,-0.83,3.49705,-5.128,-0.82,91,95,-0.892,8,8,0,0,"helix",-0.8,8.33,0.0002156101768003,29.1287878787879,511969.848429232,Inf,9.2872640727157,-82,-48,0,-2,-46,0,0,0,0,2,0,2,0,0,0,0,0,1,0,3,-2,-6,0,-4,-6,-0.313576494427558,-0.214470284237726,0.127370173151028,-0.874339300937766,-0.214659685863874,0.957894736842105,-0.734761120263591,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","147/150","S:E:T",13.1460210125009,0.907969111549634,113.719344731975,0.115600569485207,0.183926936276726,NA,1.4643224129316,0.0049931328456149,2.3016268790981,2.00455510251839,Inf,0.0023075254069185,"lineage6","dr_mutations_pyrazinamide","LYS",0,"ERR2516338","ERR2516338","lineage6","be","Belgium","pnca_p.thr142lys","A","H","THR","TA142","pnca_complex.pdb"
|
|
"T142K","L4","PZA","T","T142",142,"K",NA,"MDR","DM","hydrophobic","hydrophobic","neutral","basic","polar","pos",8.098,-1.238,-0.83,3.49705,-5.128,-0.82,91,95,-0.892,8,8,0,0,"helix",-0.8,8.33,0.0002156101768003,29.1287878787879,511969.848429232,Inf,9.2872640727157,-82,-48,0,-2,-46,0,0,0,0,2,0,2,0,0,0,0,0,1,0,3,-2,-6,0,-4,-6,-0.313576494427558,-0.214470284237726,0.127370173151028,-0.874339300937766,-0.214659685863874,0.957894736842105,-0.734761120263591,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","147/150","S:E:T",13.1460210125009,0.907969111549634,113.719344731975,0.115600569485207,0.183926936276726,NA,1.4643224129316,0.0049931328456149,2.3016268790981,2.00455510251839,Inf,0.0023075254069185,"lineage4","dr_mutations_pyrazinamide","LYS",0,"SAMN02414877","SRR1165592_SRR1165512_SRR1162828_SRR1166922","lineage4.8","se","Sweden","pnca_p.thr142lys","A","H","THR","TA142","pnca_complex.pdb"
|
|
"T142K","L4","PZA","T","T142",142,"K",NA,"MDR","DM","hydrophobic","hydrophobic","neutral","basic","polar","pos",8.098,-1.238,-0.83,3.49705,-5.128,-0.82,91,95,-0.892,8,8,0,0,"helix",-0.8,8.33,0.0002156101768003,29.1287878787879,511969.848429232,Inf,9.2872640727157,-82,-48,0,-2,-46,0,0,0,0,2,0,2,0,0,0,0,0,1,0,3,-2,-6,0,-4,-6,-0.313576494427558,-0.214470284237726,0.127370173151028,-0.874339300937766,-0.214659685863874,0.957894736842105,-0.734761120263591,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","147/150","S:E:T",13.1460210125009,0.907969111549634,113.719344731975,0.115600569485207,0.183926936276726,NA,1.4643224129316,0.0049931328456149,2.3016268790981,2.00455510251839,Inf,0.0023075254069185,"lineage4","dr_mutations_pyrazinamide","LYS",0,"SAMN02414844","SRR1166710_SRR1162720_SRR1165600_SRR1165544","lineage4.8","se","Sweden","pnca_p.thr142lys","A","H","THR","TA142","pnca_complex.pdb"
|
|
"T142K","L2","PZA","T","T142",142,"K",1,"Pre-XDR","DM","hydrophobic","hydrophobic","neutral","basic","polar","pos",8.098,-1.238,-0.83,3.49705,-5.128,-0.82,91,95,-0.892,8,8,0,0,"helix",-0.8,8.33,0.0002156101768003,29.1287878787879,511969.848429232,Inf,9.2872640727157,-82,-48,0,-2,-46,0,0,0,0,2,0,2,0,0,0,0,0,1,0,3,-2,-6,0,-4,-6,-0.313576494427558,-0.214470284237726,0.127370173151028,-0.874339300937766,-0.214659685863874,0.957894736842105,-0.734761120263591,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","147/150","S:E:T",13.1460210125009,0.907969111549634,113.719344731975,0.115600569485207,0.183926936276726,NA,1.4643224129316,0.0049931328456149,2.3016268790981,2.00455510251839,Inf,0.0023075254069185,"lineage2","dr_mutations_pyrazinamide","LYS",0,"MDR_4204","SRR6824584","lineage2.2.2","cn","China: Yaodu District, Linfen City, Shanxi Province ","pnca_p.thr142lys","A","H","THR","TA142","pnca_complex.pdb"
|
|
"T142K","L1","PZA","T","T142",142,"K",NA,"MDR","DM","hydrophobic","hydrophobic","neutral","basic","polar","pos",8.098,-1.238,-0.83,3.49705,-5.128,-0.82,91,95,-0.892,8,8,0,0,"helix",-0.8,8.33,0.0002156101768003,29.1287878787879,511969.848429232,Inf,9.2872640727157,-82,-48,0,-2,-46,0,0,0,0,2,0,2,0,0,0,0,0,1,0,3,-2,-6,0,-4,-6,-0.313576494427558,-0.214470284237726,0.127370173151028,-0.874339300937766,-0.214659685863874,0.957894736842105,-0.734761120263591,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","147/150","S:E:T",13.1460210125009,0.907969111549634,113.719344731975,0.115600569485207,0.183926936276726,NA,1.4643224129316,0.0049931328456149,2.3016268790981,2.00455510251839,Inf,0.0023075254069185,"lineage1","dr_mutations_pyrazinamide","LYS",0,"SAMN07236334,SRR5709819","SRR5709819","lineage1.1.1","th","Thailand","pnca_p.thr142lys","A","H","THR","TA142","pnca_complex.pdb"
|
|
"T142K","L6","PZA","T","T142",142,"K",1,"MDR","DM","hydrophobic","hydrophobic","neutral","basic","polar","pos",8.098,-1.238,-0.83,3.49705,-5.128,-0.82,91,95,-0.892,8,8,0,0,"helix",-0.8,8.33,0.0002156101768003,29.1287878787879,511969.848429232,Inf,9.2872640727157,-82,-48,0,-2,-46,0,0,0,0,2,0,2,0,0,0,0,0,1,0,3,-2,-6,0,-4,-6,-0.313576494427558,-0.214470284237726,0.127370173151028,-0.874339300937766,-0.214659685863874,0.957894736842105,-0.734761120263591,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","147/150","S:E:T",13.1460210125009,0.907969111549634,113.719344731975,0.115600569485207,0.183926936276726,NA,1.4643224129316,0.0049931328456149,2.3016268790981,2.00455510251839,Inf,0.0023075254069185,"lineage6","dr_mutations_pyrazinamide","LYS",0,"ERR2516316","ERR2516316","lineage6","be","Belgium","pnca_p.thr142lys","A","H","THR","TA142","pnca_complex.pdb"
|
|
"T142M","L2","PZA","T","T142",142,"M",1,"MDR","DM","hydrophobic","hydrophobic","neutral","non-polar","polar","non-polar",8.098,-1.836,0.175,-0.886939,-1.977,-0.23,85,91,-0.892,8,8,0,0,"helix",-0.8,8.33,0.0002156101768003,9.70466975178797,9.70465898653051,9.70194990589383,2.29168245016684,-56,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,-3,0,1,-4,0,0,0,0,-0.465045592705167,0.148809523809524,-0.170525840190725,-0.337084398976982,-0.0602094240837696,0.894736842105263,-0.734761120263591,"Destabilising","Stabilising","Stabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","147/150","S:E:T",2.27260607808817,0.0634455902260899,1.22442760158496,1.8560559033024,0.929172866365547,208.881603004778,0.986980761010679,0.0776844925942494,1.10966566656461,0.504888890842109,570.372842410328,0.130068862702538,"lineage2","dr_mutations_pyrazinamide","MET",0,"MDR_2167","SRR6824708","lineage2.2.1","cn","China: Heping District, Tianjin","pnca_p.thr142met","A","H","THR","TA142","pnca_complex.pdb"
|
|
"T142M","L4","PZA","T","T142",142,"M",1,"MDR","DM","hydrophobic","hydrophobic","neutral","non-polar","polar","non-polar",8.098,-1.836,0.175,-0.886939,-1.977,-0.23,85,91,-0.892,8,8,0,0,"helix",-0.8,8.33,0.0002156101768003,9.70466975178797,9.70465898653051,9.70194990589383,2.29168245016684,-56,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,-3,0,1,-4,0,0,0,0,-0.465045592705167,0.148809523809524,-0.170525840190725,-0.337084398976982,-0.0602094240837696,0.894736842105263,-0.734761120263591,"Destabilising","Stabilising","Stabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","147/150","S:E:T",2.27260607808817,0.0634455902260899,1.22442760158496,1.8560559033024,0.929172866365547,208.881603004778,0.986980761010679,0.0776844925942494,1.10966566656461,0.504888890842109,570.372842410328,0.130068862702538,"lineage4","dr_mutations_pyrazinamide","MET",0,"ERR2510698","ERR2510698","lineage4.5","pk","Pakistan","pnca_p.thr142met","A","H","THR","TA142","pnca_complex.pdb"
|
|
"T142M","L3","PZA","T","T142",142,"M",0,"Other","DM","hydrophobic","hydrophobic","neutral","non-polar","polar","non-polar",8.098,-1.836,0.175,-0.886939,-1.977,-0.23,85,91,-0.892,8,8,0,0,"helix",-0.8,8.33,0.0002156101768003,9.70466975178797,9.70465898653051,9.70194990589383,2.29168245016684,-56,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,-3,0,1,-4,0,0,0,0,-0.465045592705167,0.148809523809524,-0.170525840190725,-0.337084398976982,-0.0602094240837696,0.894736842105263,-0.734761120263591,"Destabilising","Stabilising","Stabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","147/150","S:E:T",2.27260607808817,0.0634455902260899,1.22442760158496,1.8560559033024,0.929172866365547,208.881603004778,0.986980761010679,0.0776844925942494,1.10966566656461,0.504888890842109,570.372842410328,0.130068862702538,"lineage3","dr_mutations_pyrazinamide","MET",0,"ERR2514151","ERR2514151","lineage3","gb","UK","pnca_p.thr142met","A","H","THR","TA142","pnca_complex.pdb"
|
|
"T142M","L2","PZA","T","T142",142,"M",NA,"MDR","DM","hydrophobic","hydrophobic","neutral","non-polar","polar","non-polar",8.098,-1.836,0.175,-0.886939,-1.977,-0.23,85,91,-0.892,8,8,0,0,"helix",-0.8,8.33,0.0002156101768003,9.70466975178797,9.70465898653051,9.70194990589383,2.29168245016684,-56,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,-3,0,1,-4,0,0,0,0,-0.465045592705167,0.148809523809524,-0.170525840190725,-0.337084398976982,-0.0602094240837696,0.894736842105263,-0.734761120263591,"Destabilising","Stabilising","Stabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","147/150","S:E:T",2.27260607808817,0.0634455902260899,1.22442760158496,1.8560559033024,0.929172866365547,208.881603004778,0.986980761010679,0.0776844925942494,1.10966566656461,0.504888890842109,570.372842410328,0.130068862702538,"lineage2","dr_mutations_pyrazinamide","MET",0,"ERR137259,1693R-sc-2012-02-21T11:37:01Z-1364751","ERR137259","lineage2.2.1","ru","Russia","pnca_p.thr142met","A","H","THR","TA142","pnca_complex.pdb"
|
|
"T142M","L4","PZA","T","T142",142,"M",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","neutral","non-polar","polar","non-polar",8.098,-1.836,0.175,-0.886939,-1.977,-0.23,85,91,-0.892,8,8,0,0,"helix",-0.8,8.33,0.0002156101768003,9.70466975178797,9.70465898653051,9.70194990589383,2.29168245016684,-56,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,-3,0,1,-4,0,0,0,0,-0.465045592705167,0.148809523809524,-0.170525840190725,-0.337084398976982,-0.0602094240837696,0.894736842105263,-0.734761120263591,"Destabilising","Stabilising","Stabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","147/150","S:E:T",2.27260607808817,0.0634455902260899,1.22442760158496,1.8560559033024,0.929172866365547,208.881603004778,0.986980761010679,0.0776844925942494,1.10966566656461,0.504888890842109,570.372842410328,0.130068862702538,"lineage4","dr_mutations_pyrazinamide","MET",0,"SAMN02231153","SRR1049968_SRR998750_SRR998749_SRR998751_SRR998748","lineage4.1","ml","Mali","pnca_p.thr142met","A","H","THR","TA142","pnca_complex.pdb"
|
|
"T142M","L2","PZA","T","T142",142,"M",NA,"MDR","DM","hydrophobic","hydrophobic","neutral","non-polar","polar","non-polar",8.098,-1.836,0.175,-0.886939,-1.977,-0.23,85,91,-0.892,8,8,0,0,"helix",-0.8,8.33,0.0002156101768003,9.70466975178797,9.70465898653051,9.70194990589383,2.29168245016684,-56,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,-3,0,1,-4,0,0,0,0,-0.465045592705167,0.148809523809524,-0.170525840190725,-0.337084398976982,-0.0602094240837696,0.894736842105263,-0.734761120263591,"Destabilising","Stabilising","Stabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","147/150","S:E:T",2.27260607808817,0.0634455902260899,1.22442760158496,1.8560559033024,0.929172866365547,208.881603004778,0.986980761010679,0.0776844925942494,1.10966566656461,0.504888890842109,570.372842410328,0.130068862702538,"lineage2","dr_mutations_pyrazinamide","MET",0,"SRR6397962","SRR6397962","lineage2.2.1.2","ca","Canada","pnca_p.thr142met","A","H","THR","TA142","pnca_complex.pdb"
|
|
"T142M","L3","PZA","T","T142",142,"M",NA,"Other","DM","hydrophobic","hydrophobic","neutral","non-polar","polar","non-polar",8.098,-1.836,0.175,-0.886939,-1.977,-0.23,85,91,-0.892,8,8,0,0,"helix",-0.8,8.33,0.0002156101768003,9.70466975178797,9.70465898653051,9.70194990589383,2.29168245016684,-56,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,-3,0,1,-4,0,0,0,0,-0.465045592705167,0.148809523809524,-0.170525840190725,-0.337084398976982,-0.0602094240837696,0.894736842105263,-0.734761120263591,"Destabilising","Stabilising","Stabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","147/150","S:E:T",2.27260607808817,0.0634455902260899,1.22442760158496,1.8560559033024,0.929172866365547,208.881603004778,0.986980761010679,0.0776844925942494,1.10966566656461,0.504888890842109,570.372842410328,0.130068862702538,"lineage3","dr_mutations_pyrazinamide","MET",0,"SAMN07659069","SRR6044963","lineage3","gb","UK","pnca_p.thr142met","A","H","THR","TA142","pnca_complex.pdb"
|
|
"T142M","L2","PZA","T","T142",142,"M",NA,"Pre-MDR","DM","hydrophobic","hydrophobic","neutral","non-polar","polar","non-polar",8.098,-1.836,0.175,-0.886939,-1.977,-0.23,85,91,-0.892,8,8,0,0,"helix",-0.8,8.33,0.0002156101768003,9.70466975178797,9.70465898653051,9.70194990589383,2.29168245016684,-56,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,-3,0,1,-4,0,0,0,0,-0.465045592705167,0.148809523809524,-0.170525840190725,-0.337084398976982,-0.0602094240837696,0.894736842105263,-0.734761120263591,"Destabilising","Stabilising","Stabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","147/150","S:E:T",2.27260607808817,0.0634455902260899,1.22442760158496,1.8560559033024,0.929172866365547,208.881603004778,0.986980761010679,0.0776844925942494,1.10966566656461,0.504888890842109,570.372842410328,0.130068862702538,"lineage2","dr_mutations_pyrazinamide","MET",0,"SRR6152674","SRR6152674","lineage2.2.1","ca","Canada","pnca_p.thr142met","A","H","THR","TA142","pnca_complex.pdb"
|
|
"T142M","L4","PZA","T","T142",142,"M",NA,"XDR","DM","hydrophobic","hydrophobic","neutral","non-polar","polar","non-polar",8.098,-1.836,0.175,-0.886939,-1.977,-0.23,85,91,-0.892,8,8,0,0,"helix",-0.8,8.33,0.0002156101768003,9.70466975178797,9.70465898653051,9.70194990589383,2.29168245016684,-56,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,-3,0,1,-4,0,0,0,0,-0.465045592705167,0.148809523809524,-0.170525840190725,-0.337084398976982,-0.0602094240837696,0.894736842105263,-0.734761120263591,"Destabilising","Stabilising","Stabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","147/150","S:E:T",2.27260607808817,0.0634455902260899,1.22442760158496,1.8560559033024,0.929172866365547,208.881603004778,0.986980761010679,0.0776844925942494,1.10966566656461,0.504888890842109,570.372842410328,0.130068862702538,"lineage4","dr_mutations_pyrazinamide","MET",0,"SAMN02567727","SRR1166137","lineage4.8","ro","Romania","pnca_p.thr142met","A","H","THR","TA142","pnca_complex.pdb"
|
|
"T142P","L2","PZA","T","T142",142,"P",NA,"XDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",8.098,-1.638,-0.706,6.72536,-4.677,-0.54,92,95,-0.892,8,8,0,0,"helix",-0.8,8.33,0.0001437401178668,19.411022297013,511754.463554492,Inf,4.73122070382274,4,-25,0,0,-25,0,0,0,0,4,2,2,0,0,0,0,0,4,4,0,-2,6,0,-2,4,-0.414893617021277,-0.182428940568475,0.2449522505263,-0.797442455242967,-0.141361256544503,0.968421052631579,-0.734761120263591,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","147/150","S:E:T",13.1456002256242,0.924803768447115,139.277183326822,0.0943844491367787,0.0001628371344392,NA,1.28804840845689,0.0292235860951597,1.53426649183163,0.91081598550184,Inf,0.0296198560706035,"lineage2","dr_mutations_pyrazinamide","PRO",0,"SAMN02584649","SRR1169151_SRR1166145","lineage2.2.1","md","Moldova","pnca_p.thr142pro","A","H","THR","TA142","pnca_complex.pdb"
|
|
"T142P","L4","PZA","T","T142",142,"P",1,"MDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",8.098,-1.638,-0.706,6.72536,-4.677,-0.54,92,95,-0.892,8,8,0,0,"helix",-0.8,8.33,0.0001437401178668,19.411022297013,511754.463554492,Inf,4.73122070382274,4,-25,0,0,-25,0,0,0,0,4,2,2,0,0,0,0,0,4,4,0,-2,6,0,-2,4,-0.414893617021277,-0.182428940568475,0.2449522505263,-0.797442455242967,-0.141361256544503,0.968421052631579,-0.734761120263591,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","147/150","S:E:T",13.1456002256242,0.924803768447115,139.277183326822,0.0943844491367787,0.0001628371344392,NA,1.28804840845689,0.0292235860951597,1.53426649183163,0.91081598550184,Inf,0.0296198560706035,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR2516599","ERR2516599","lineage4","pe","Peru","pnca_p.thr142pro","A","H","THR","TA142","pnca_complex.pdb"
|
|
"T142P","L4","PZA","T","T142",142,"P",NA,"MDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",8.098,-1.638,-0.706,6.72536,-4.677,-0.54,92,95,-0.892,8,8,0,0,"helix",-0.8,8.33,0.0001437401178668,19.411022297013,511754.463554492,Inf,4.73122070382274,4,-25,0,0,-25,0,0,0,0,4,2,2,0,0,0,0,0,4,4,0,-2,6,0,-2,4,-0.414893617021277,-0.182428940568475,0.2449522505263,-0.797442455242967,-0.141361256544503,0.968421052631579,-0.734761120263591,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","147/150","S:E:T",13.1456002256242,0.924803768447115,139.277183326822,0.0943844491367787,0.0001628371344392,NA,1.28804840845689,0.0292235860951597,1.53426649183163,0.91081598550184,Inf,0.0296198560706035,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR2707133","ERR2707133","lineage4.3.3","cd","Democratic Republic of Congo","pnca_p.thr142pro","A","H","THR","TA142","pnca_complex.pdb"
|
|
"T142P","L2","PZA","T","T142",142,"P",1,"MDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",8.098,-1.638,-0.706,6.72536,-4.677,-0.54,92,95,-0.892,8,8,0,0,"helix",-0.8,8.33,0.0001437401178668,19.411022297013,511754.463554492,Inf,4.73122070382274,4,-25,0,0,-25,0,0,0,0,4,2,2,0,0,0,0,0,4,4,0,-2,6,0,-2,4,-0.414893617021277,-0.182428940568475,0.2449522505263,-0.797442455242967,-0.141361256544503,0.968421052631579,-0.734761120263591,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","147/150","S:E:T",13.1456002256242,0.924803768447115,139.277183326822,0.0943844491367787,0.0001628371344392,NA,1.28804840845689,0.0292235860951597,1.53426649183163,0.91081598550184,Inf,0.0296198560706035,"lineage2","dr_mutations_pyrazinamide","PRO",0,"ERR2041720","ERR2041720","lineage2.2.1","rs","Serbia","pnca_p.thr142pro","A","H","THR","TA142","pnca_complex.pdb"
|
|
"T142R","L4","PZA","T","T142",142,"R",NA,"MDR","OM","hydrophobic","hydrophilic","neutral","basic","polar","pos",8.098,-1.267,-0.733,5.15889,-4.739,-0.89,91,95,-0.892,8,8,0,0,"helix",-0.8,8.33,NA,NA,NA,NA,NA,-106,-34,0,0,-34,0,0,0,0,-2,0,4,-4,0,0,0,0,-9,0,0,-9,-10,0,-14,-4,-0.320921985815603,-0.189405684754522,0.187898003336271,-0.808013640238704,-0.232984293193717,0.957894736842105,-0.734761120263591,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","147/150","S:E:T",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage4","other_mutations_pyrazinamide","ARG",0,"ERR1199137","ERR1199137","lineage4.6.1.2","ug","Uganda","pnca_p.thr142arg","A","H","THR","TA142","pnca_complex.pdb"
|
|
"A143D","L3","PZA","A","A143",143,"D",0,"MDR","DM","hydrophobic","hydrophilic","non-polar","acidic","non-polar","neg",10.807,0.346,-3.46,5.46827,-5.865,-1.17,84,91,-0.834,8,8,0,0,"helix",-0.8,8.82,0.0001437401178668,4.85029436501262,4.85029432717734,4.84956447904112,0.0881192621863332,-14,-46,0,-2,-44,0,0,0,0,0,0,0,0,0,0,0,0,-9,0,-1,-8,-6,0,-4,-3,0.155156950672646,-0.89405684754522,0.199166296374537,-1,-0.306282722513089,0.884210526315789,-0.686985172981878,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.955,-0.779,"9:8","147/150","I:C:V:S:A:T",1.57903938912402,0.264247566376723,1.41439286276584,1.11640791656443,0.191756076673654,122.683760399096,0.685768096792206,0.312734154310187,0.504824686014995,0.061763864579114,379.558337204203,0.766581879696361,"lineage3","dr_mutations_pyrazinamide","ASP",0,"ERR2517002","ERR2517002","lineage3.1.2.1","gb","UK","pnca_p.ala143asp","A","H","ALA","AA143","pnca_complex.pdb"
|
|
"A143D","L3","PZA","A","A143",143,"D",1,"MDR","DM","hydrophobic","hydrophilic","non-polar","acidic","non-polar","neg",10.807,0.346,-3.46,5.46827,-5.865,-1.17,84,91,-0.834,8,8,0,0,"helix",-0.8,8.82,0.0001437401178668,4.85029436501262,4.85029432717734,4.84956447904112,0.0881192621863332,-14,-46,0,-2,-44,0,0,0,0,0,0,0,0,0,0,0,0,-9,0,-1,-8,-6,0,-4,-3,0.155156950672646,-0.89405684754522,0.199166296374537,-1,-0.306282722513089,0.884210526315789,-0.686985172981878,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.955,-0.779,"9:8","147/150","I:C:V:S:A:T",1.57903938912402,0.264247566376723,1.41439286276584,1.11640791656443,0.191756076673654,122.683760399096,0.685768096792206,0.312734154310187,0.504824686014995,0.061763864579114,379.558337204203,0.766581879696361,"lineage3","dr_mutations_pyrazinamide","ASP",0,"ERR2510524","ERR2510524","lineage3","pk","Pakistan","pnca_p.ala143asp","A","H","ALA","AA143","pnca_complex.pdb"
|
|
"A143D","L2","PZA","A","A143",143,"D",NA,"MDR","DM","hydrophobic","hydrophilic","non-polar","acidic","non-polar","neg",10.807,0.346,-3.46,5.46827,-5.865,-1.17,84,91,-0.834,8,8,0,0,"helix",-0.8,8.82,0.0001437401178668,4.85029436501262,4.85029432717734,4.84956447904112,0.0881192621863332,-14,-46,0,-2,-44,0,0,0,0,0,0,0,0,0,0,0,0,-9,0,-1,-8,-6,0,-4,-3,0.155156950672646,-0.89405684754522,0.199166296374537,-1,-0.306282722513089,0.884210526315789,-0.686985172981878,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.955,-0.779,"9:8","147/150","I:C:V:S:A:T",1.57903938912402,0.264247566376723,1.41439286276584,1.11640791656443,0.191756076673654,122.683760399096,0.685768096792206,0.312734154310187,0.504824686014995,0.061763864579114,379.558337204203,0.766581879696361,"lineage2","dr_mutations_pyrazinamide","ASP",0,"SRR5065228","SRR5065228","lineage2.2.1","vn","Vietnam","pnca_p.ala143asp","A","H","ALA","AA143","pnca_complex.pdb"
|
|
"A143G","L4","PZA","A","A143",143,"G",1,"XDR","OM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",10.807,-0.868,-2.08,2.31533,-3.708,-2.04,72,85,-0.834,8,8,0,0,"helix",-0.8,8.82,0.0003593502946672,48.5888795282224,1392863.97690657,Inf,18.7541888696359,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,2,0,5,18,-0.219858156028369,-0.537467700258398,0.084329358459779,-0.632225063938619,-0.534031413612565,0.757894736842105,-0.686985172981878,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.955,-0.779,"9:8","147/150","I:C:V:S:A:T",14.1468726004037,0.922400595820385,145.229797685252,0.0974102617085742,0.390278156381537,NA,1.68653688423854,0.0001456121755417,3.83680230943558,4.44801917882778,Inf,1.4869638142509e-05,"lineage4","other_mutations_pyrazinamide","GLY",0,"ERR2510826","ERR2510826","lineage4.1.2.1","it","Italy","pnca_p.ala143gly","A","H","ALA","AA143","pnca_complex.pdb"
|
|
"A143G","L4","PZA","A","A143",143,"G",1,"XDR","OM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",10.807,-0.868,-2.08,2.31533,-3.708,-2.04,72,85,-0.834,8,8,0,0,"helix",-0.8,8.82,0.0003593502946672,48.5888795282224,1392863.97690657,Inf,18.7541888696359,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,2,0,5,18,-0.219858156028369,-0.537467700258398,0.084329358459779,-0.632225063938619,-0.534031413612565,0.757894736842105,-0.686985172981878,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.955,-0.779,"9:8","147/150","I:C:V:S:A:T",14.1468726004037,0.922400595820385,145.229797685252,0.0974102617085742,0.390278156381537,NA,1.68653688423854,0.0001456121755417,3.83680230943558,4.44801917882778,Inf,1.4869638142509e-05,"lineage4","other_mutations_pyrazinamide","GLY",0,"ERR2510827","ERR2510827","lineage4.1.2.1","it","Italy","pnca_p.ala143gly","A","H","ALA","AA143","pnca_complex.pdb"
|
|
"A143G","L4","PZA","A","A143",143,"G",1,"XDR","OM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",10.807,-0.868,-2.08,2.31533,-3.708,-2.04,72,85,-0.834,8,8,0,0,"helix",-0.8,8.82,0.0003593502946672,48.5888795282224,1392863.97690657,Inf,18.7541888696359,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,2,0,5,18,-0.219858156028369,-0.537467700258398,0.084329358459779,-0.632225063938619,-0.534031413612565,0.757894736842105,-0.686985172981878,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.955,-0.779,"9:8","147/150","I:C:V:S:A:T",14.1468726004037,0.922400595820385,145.229797685252,0.0974102617085742,0.390278156381537,NA,1.68653688423854,0.0001456121755417,3.83680230943558,4.44801917882778,Inf,1.4869638142509e-05,"lineage4","other_mutations_pyrazinamide","GLY",0,"ERR2510844","ERR2510844","lineage4.1.2.1","it","Italy","pnca_p.ala143gly","A","H","ALA","AA143","pnca_complex.pdb"
|
|
"A143G","L4","PZA","A","A143",143,"G",1,"XDR","OM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",10.807,-0.868,-2.08,2.31533,-3.708,-2.04,72,85,-0.834,8,8,0,0,"helix",-0.8,8.82,0.0003593502946672,48.5888795282224,1392863.97690657,Inf,18.7541888696359,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,2,0,5,18,-0.219858156028369,-0.537467700258398,0.084329358459779,-0.632225063938619,-0.534031413612565,0.757894736842105,-0.686985172981878,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.955,-0.779,"9:8","147/150","I:C:V:S:A:T",14.1468726004037,0.922400595820385,145.229797685252,0.0974102617085742,0.390278156381537,NA,1.68653688423854,0.0001456121755417,3.83680230943558,4.44801917882778,Inf,1.4869638142509e-05,"lineage4","other_mutations_pyrazinamide","GLY",0,"ERR2510671","ERR2510671","lineage4.1.2.1","it","Italy","pnca_p.ala143gly","A","H","ALA","AA143","pnca_complex.pdb"
|
|
"A143G","L4","PZA","A","A143",143,"G",1,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",10.807,-0.868,-2.08,2.31533,-3.708,-2.04,72,85,-0.834,8,8,0,0,"helix",-0.8,8.82,0.0003593502946672,48.5888795282224,1392863.97690657,Inf,18.7541888696359,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,2,0,5,18,-0.219858156028369,-0.537467700258398,0.084329358459779,-0.632225063938619,-0.534031413612565,0.757894736842105,-0.686985172981878,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.955,-0.779,"9:8","147/150","I:C:V:S:A:T",14.1468726004037,0.922400595820385,145.229797685252,0.0974102617085742,0.390278156381537,NA,1.68653688423854,0.0001456121755417,3.83680230943558,4.44801917882778,Inf,1.4869638142509e-05,"lineage4","other_mutations_pyrazinamide","GLY",0,"ERR2510864","ERR2510864","lineage4.1.2.1","it","Italy","pnca_p.ala143gly","A","H","ALA","AA143","pnca_complex.pdb"
|
|
"A143P","L1","PZA","A","A143",143,"P",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",10.807,-0.732,-1.416,2.35082,-3.997,-0.21,85,91,-0.834,8,8,0,0,"helix",-0.8,8.82,NA,NA,NA,NA,NA,0,0,0,0,0,0,0,0,0,2,2,-2,0,0,0,0,0,3,4,1,-2,-2,0,-2,-5,-0.185410334346505,-0.365891472868217,0.0856219815121031,-0.681500426257459,-0.0549738219895288,0.894736842105263,-0.686985172981878,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.955,-0.779,"9:8","147/150","I:C:V:S:A:T",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage1","dr_mutations_pyrazinamide","PRO",0,"SAMN07236269,SRR5709755","SRR5709755","lineage1.1.1","th","Thailand","pnca_p.ala143pro","A","H","ALA","AA143","pnca_complex.pdb"
|
|
"A143T","L2","PZA","A","A143",143,"T",1,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",10.807,0.07,-2.359,0.406768,-2.811,-1.46,47,71,-0.834,8,8,0,0,"helix",-0.8,8.82,0.0001437401178668,4.85029436501262,4.85029432717732,4.84956447904112,0.0881192621863332,-8,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,-10,0,-4,-8,-6,0,-6,-5,0.0313901345291479,-0.609560723514212,0.0148153759861304,-0.479283887468031,-0.382198952879581,0.494736842105263,-0.686985172981878,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.955,-0.779,"9:8","147/150","I:C:V:S:A:T",1.57903938912401,0.264247566376724,1.41439286276584,1.11640791656443,0.191756076673653,122.683760399095,0.685768096792206,0.312734154310187,0.504824686014995,0.061763864579114,379.558337204203,0.766581879696361,"lineage2","dr_mutations_pyrazinamide","THR",0,"0802Y-sc-2012-02-09T18:57:12Z-1355278,ERR133945","ERR133945","lineage2.2.1","ru","Russia","pnca_p.ala143thr","A","H","ALA","AA143","pnca_complex.pdb"
|
|
"A143T","L2","PZA","A","A143",143,"T",0,"XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",10.807,0.07,-2.359,0.406768,-2.811,-1.46,47,71,-0.834,8,8,0,0,"helix",-0.8,8.82,0.0001437401178668,4.85029436501262,4.85029432717732,4.84956447904112,0.0881192621863332,-8,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,-10,0,-4,-8,-6,0,-6,-5,0.0313901345291479,-0.609560723514212,0.0148153759861304,-0.479283887468031,-0.382198952879581,0.494736842105263,-0.686985172981878,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.955,-0.779,"9:8","147/150","I:C:V:S:A:T",1.57903938912401,0.264247566376724,1.41439286276584,1.11640791656443,0.191756076673653,122.683760399095,0.685768096792206,0.312734154310187,0.504824686014995,0.061763864579114,379.558337204203,0.766581879696361,"lineage2","dr_mutations_pyrazinamide","THR",0,"ERR144574,1858W-sc-2012-02-21T11:37:45Z-1364811","ERR144574","lineage2.2.1","ru","Russia,Samara","pnca_p.ala143thr","A","H","ALA","AA143","pnca_complex.pdb"
|
|
"A143V","L2","PZA","A","A143",143,"V",0,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",10.807,-1.168,-0.622,0.113853,-1.998,-0.56,-16,57,-0.834,8,8,0,0,"helix",-0.8,8.82,0.0003593502946672,0.484657419083649,1.69068633684891e-05,0,0.177777263899814,-8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-12,0,-6,-6,-2,0,-2,-7,-0.295845997973658,-0.160723514211886,0.00414677408780658,-0.340664961636829,-0.146596858638743,-0.172043010752688,-0.686985172981878,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","neutral",-0.955,-0.779,"9:8","147/150","I:C:V:S:A:T",-10.9877909019996,0.939691219428539,145.229797681912,-0.0756579646696575,NA,60.3389082676124,-0.314565134742567,0.596111875058711,0.224672226566594,0,5.29224350433385,0.673290424524484,"lineage2","other_mutations_pyrazinamide","VAL",0,"SRR2100911,SAMN03648084","SRR2100911","lineage2.2.1","","","pnca_p.ala143val","A","H","ALA","AA143","pnca_complex.pdb"
|
|
"A143V","L2","PZA","A","A143",143,"V",0,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",10.807,-1.168,-0.622,0.113853,-1.998,-0.56,-16,57,-0.834,8,8,0,0,"helix",-0.8,8.82,0.0003593502946672,0.484657419083649,1.69068633684891e-05,0,0.177777263899814,-8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-12,0,-6,-6,-2,0,-2,-7,-0.295845997973658,-0.160723514211886,0.00414677408780658,-0.340664961636829,-0.146596858638743,-0.172043010752688,-0.686985172981878,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","neutral",-0.955,-0.779,"9:8","147/150","I:C:V:S:A:T",-10.9877909019996,0.939691219428539,145.229797681912,-0.0756579646696575,NA,60.3389082676124,-0.314565134742567,0.596111875058711,0.224672226566594,0,5.29224350433385,0.673290424524484,"lineage2","other_mutations_pyrazinamide","VAL",0,"SRR2100870,SAMN03648043","SRR2100870","lineage2.2.1","","","pnca_p.ala143val","A","H","ALA","AA143","pnca_complex.pdb"
|
|
"A143V","L2","PZA","A","A143",143,"V",0,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",10.807,-1.168,-0.622,0.113853,-1.998,-0.56,-16,57,-0.834,8,8,0,0,"helix",-0.8,8.82,0.0003593502946672,0.484657419083649,1.69068633684891e-05,0,0.177777263899814,-8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-12,0,-6,-6,-2,0,-2,-7,-0.295845997973658,-0.160723514211886,0.00414677408780658,-0.340664961636829,-0.146596858638743,-0.172043010752688,-0.686985172981878,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","neutral",-0.955,-0.779,"9:8","147/150","I:C:V:S:A:T",-10.9877909019996,0.939691219428539,145.229797681912,-0.0756579646696575,NA,60.3389082676124,-0.314565134742567,0.596111875058711,0.224672226566594,0,5.29224350433385,0.673290424524484,"lineage2","other_mutations_pyrazinamide","VAL",0,"SRR2100889,SAMN03648062","SRR2100889","lineage2.2.1","","","pnca_p.ala143val","A","H","ALA","AA143","pnca_complex.pdb"
|
|
"A143V","L2","PZA","A","A143",143,"V",NA,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",10.807,-1.168,-0.622,0.113853,-1.998,-0.56,-16,57,-0.834,8,8,0,0,"helix",-0.8,8.82,0.0003593502946672,0.484657419083649,1.69068633684891e-05,0,0.177777263899814,-8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-12,0,-6,-6,-2,0,-2,-7,-0.295845997973658,-0.160723514211886,0.00414677408780658,-0.340664961636829,-0.146596858638743,-0.172043010752688,-0.686985172981878,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","neutral",-0.955,-0.779,"9:8","147/150","I:C:V:S:A:T",-10.9877909019996,0.939691219428539,145.229797681912,-0.0756579646696575,NA,60.3389082676124,-0.314565134742567,0.596111875058711,0.224672226566594,0,5.29224350433385,0.673290424524484,"lineage2","other_mutations_pyrazinamide","VAL",0,"ERR2516858","ERR2516858","lineage2.2.1","gb","UK","pnca_p.ala143val","A","H","ALA","AA143","pnca_complex.pdb"
|
|
"A143V","L2","PZA","A","A143",143,"V",NA,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",10.807,-1.168,-0.622,0.113853,-1.998,-0.56,-16,57,-0.834,8,8,0,0,"helix",-0.8,8.82,0.0003593502946672,0.484657419083649,1.69068633684891e-05,0,0.177777263899814,-8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-12,0,-6,-6,-2,0,-2,-7,-0.295845997973658,-0.160723514211886,0.00414677408780658,-0.340664961636829,-0.146596858638743,-0.172043010752688,-0.686985172981878,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","neutral",-0.955,-0.779,"9:8","147/150","I:C:V:S:A:T",-10.9877909019996,0.939691219428539,145.229797681912,-0.0756579646696575,NA,60.3389082676124,-0.314565134742567,0.596111875058711,0.224672226566594,0,5.29224350433385,0.673290424524484,"lineage2","other_mutations_pyrazinamide","VAL",0,"ERR2516897","ERR2516897","lineage2.2.1","gb","UK","pnca_p.ala143val","A","H","ALA","AA143","pnca_complex.pdb"
|
|
"A143V","L2","PZA","A","A143",143,"V",0,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",10.807,-1.168,-0.622,0.113853,-1.998,-0.56,-16,57,-0.834,8,8,0,0,"helix",-0.8,8.82,0.0003593502946672,0.484657419083649,1.69068633684891e-05,0,0.177777263899814,-8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-12,0,-6,-6,-2,0,-2,-7,-0.295845997973658,-0.160723514211886,0.00414677408780658,-0.340664961636829,-0.146596858638743,-0.172043010752688,-0.686985172981878,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","neutral",-0.955,-0.779,"9:8","147/150","I:C:V:S:A:T",-10.9877909019996,0.939691219428539,145.229797681912,-0.0756579646696575,NA,60.3389082676124,-0.314565134742567,0.596111875058711,0.224672226566594,0,5.29224350433385,0.673290424524484,"lineage2","other_mutations_pyrazinamide","VAL",0,"SRR2100873,SAMN03648046","SRR2100873","lineage2.2.1","","","pnca_p.ala143val","A","H","ALA","AA143","pnca_complex.pdb"
|
|
"A143V","L2","PZA","A","A143",143,"V",0,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",10.807,-1.168,-0.622,0.113853,-1.998,-0.56,-16,57,-0.834,8,8,0,0,"helix",-0.8,8.82,0.0003593502946672,0.484657419083649,1.69068633684891e-05,0,0.177777263899814,-8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-12,0,-6,-6,-2,0,-2,-7,-0.295845997973658,-0.160723514211886,0.00414677408780658,-0.340664961636829,-0.146596858638743,-0.172043010752688,-0.686985172981878,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","neutral",-0.955,-0.779,"9:8","147/150","I:C:V:S:A:T",-10.9877909019996,0.939691219428539,145.229797681912,-0.0756579646696575,NA,60.3389082676124,-0.314565134742567,0.596111875058711,0.224672226566594,0,5.29224350433385,0.673290424524484,"lineage2","other_mutations_pyrazinamide","VAL",0,"ERR2516863","ERR2516863","lineage2.2.1","gb","UK","pnca_p.ala143val","A","H","ALA","AA143","pnca_complex.pdb"
|
|
"D145E","L2","PZA","D","D145",145,"E",NA,"MDR","DM","hydrophilic","hydrophilic","acidic","acidic","neg","neg",11.649,-1.031,-0.148,-0.4769,-0.323,-0.78,70,85,-1.092,9,9,33,0.170984455958549,"helix",-1.73333333333333,4.71,7.18700589334483e-05,9.70142977291842,188179.926264557,Inf,0.763784339928386,-10,4,0,0,4,0,0,0,0,2,0,-2,4,0,0,0,0,-3,0,-2,-1,0,0,2,-2,-0.261144883485309,-0.0382428940568475,-0.0916903791432746,-0.0550724637681159,-0.204188481675393,0.736842105263158,-0.899505766062603,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.152,-1.062,"9:9","147/150","S:E:A:D:K",12.145153838726,0.919026337424219,119.468044436206,0.101660271548274,5.01153666065157e-06,NA,0.986835744238421,0.170978870202674,0.767057556984365,0.124324963210678,Inf,0.382146811758261,"lineage2","dr_mutations_pyrazinamide","GLU",0,"SAMN02360576","SRR1013594_SRR1048979_SRR1013593_SRR1048978","lineage2.2.2","kr","South Korea","pnca_p.asp145glu","A","H","ASP","DA145","pnca_complex.pdb"
|
|
"D145E","L4","PZA","D","D145",145,"E",1,"XDR","DM","hydrophilic","hydrophilic","acidic","acidic","neg","neg",11.649,-1.031,-0.148,-0.4769,-0.323,-0.78,70,85,-1.092,9,9,33,0.170984455958549,"helix",-1.73333333333333,4.71,7.18700589334483e-05,9.70142977291842,188179.926264557,Inf,0.763784339928386,-10,4,0,0,4,0,0,0,0,2,0,-2,4,0,0,0,0,-3,0,-2,-1,0,0,2,-2,-0.261144883485309,-0.0382428940568475,-0.0916903791432746,-0.0550724637681159,-0.204188481675393,0.736842105263158,-0.899505766062603,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.152,-1.062,"9:9","147/150","S:E:A:D:K",12.145153838726,0.919026337424219,119.468044436206,0.101660271548274,5.01153666065157e-06,NA,0.986835744238421,0.170978870202674,0.767057556984365,0.124324963210678,Inf,0.382146811758261,"lineage4","dr_mutations_pyrazinamide","GLU",0,"ERR2510867","ERR2510867","lineage4.1.2.1","it","Italy","pnca_p.asp145glu","A","H","ASP","DA145","pnca_complex.pdb"
|
|
"D145Y","L4","PZA","D","D145",145,"Y",1,"Pre-MDR","OM","hydrophilic","hydrophobic","acidic","neutral","neg","polar",11.649,-1.689,-0.409,-0.814413,-0.858,-1.05,82,91,-1.092,9,9,33,0.170984455958549,"helix",-1.73333333333333,4.71,7.18700589334483e-05,9.70142977291842,188179.926264644,Inf,0.763784339928386,-38,28,0,0,28,0,0,0,0,0,0,-4,6,0,0,0,0,-1,0,0,-2,-2,0,-2,-2,-0.427811550151976,-0.105684754521964,-0.1565817503653,-0.146291560102302,-0.274869109947644,0.863157894736842,-0.899505766062603,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.152,-1.062,"9:9","147/150","S:E:A:D:K",12.1451538387265,0.919026337424236,119.468044436235,0.101660271548254,5.01153666062444e-06,NA,0.986835744238421,0.170978870202674,0.767057556984365,0.124324963210678,Inf,0.382146811758261,"lineage4","other_mutations_pyrazinamide","TYR",0,"ERR2515552","ERR2515552","lineage4.1.1.3","za","South Africa","pnca_p.asp145tyr","A","H","ASP","DA145","pnca_complex.pdb"
|
|
"A146E","L2","PZA","A","A146",146,"E",NA,"XDR","DM","hydrophobic","hydrophilic","non-polar","acidic","non-polar","neg",14.858,0.284,-2.184,3.30206,-5.327,-0.93,75,85,-0.895,8,8,0,0,"helix",0.833333333333333,7.08,0.0001437401178668,19.411022297013,511754.463553649,Inf,4.73122070382274,-36,-46,0,-2,-44,0,0,0,0,0,0,-2,0,0,0,0,0,-6,0,-2,-7,-10,0,-8,-9,0.127354260089686,-0.564341085271318,0.120268212909476,-0.908269394714407,-0.243455497382199,0.789473684210526,-0.737232289950577,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","147/150","G:S:A",13.1456002256226,0.924803768447062,139.277183326707,0.0943844491368447,0.0001628371344419,NA,1.28804840845689,0.0292235860951597,1.53426649183163,0.91081598550184,Inf,0.0296198560706035,"lineage2","dr_mutations_pyrazinamide","GLU",0,"SAMN02628508","SRR1174308_SRR1173552","lineage2.2.1","ir","Iran","pnca_p.ala146glu","A","H","ALA","AA146","pnca_complex.pdb"
|
|
"A146E","L4","PZA","A","A146",146,"E",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","non-polar","acidic","non-polar","neg",14.858,0.284,-2.184,3.30206,-5.327,-0.93,75,85,-0.895,8,8,0,0,"helix",0.833333333333333,7.08,0.0001437401178668,19.411022297013,511754.463553649,Inf,4.73122070382274,-36,-46,0,-2,-44,0,0,0,0,0,0,-2,0,0,0,0,0,-6,0,-2,-7,-10,0,-8,-9,0.127354260089686,-0.564341085271318,0.120268212909476,-0.908269394714407,-0.243455497382199,0.789473684210526,-0.737232289950577,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","147/150","G:S:A",13.1456002256226,0.924803768447062,139.277183326707,0.0943844491368447,0.0001628371344419,NA,1.28804840845689,0.0292235860951597,1.53426649183163,0.91081598550184,Inf,0.0296198560706035,"lineage4","dr_mutations_pyrazinamide","GLU",0,"ERR751440","ERR751440","lineage4.1.2.1","pe","","pnca_p.ala146glu","A","H","ALA","AA146","pnca_complex.pdb"
|
|
"A146E","L4","PZA","A","A146",146,"E",NA,"MDR","DM","hydrophobic","hydrophilic","non-polar","acidic","non-polar","neg",14.858,0.284,-2.184,3.30206,-5.327,-0.93,75,85,-0.895,8,8,0,0,"helix",0.833333333333333,7.08,0.0001437401178668,19.411022297013,511754.463553649,Inf,4.73122070382274,-36,-46,0,-2,-44,0,0,0,0,0,0,-2,0,0,0,0,0,-6,0,-2,-7,-10,0,-8,-9,0.127354260089686,-0.564341085271318,0.120268212909476,-0.908269394714407,-0.243455497382199,0.789473684210526,-0.737232289950577,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","147/150","G:S:A",13.1456002256226,0.924803768447062,139.277183326707,0.0943844491368447,0.0001628371344419,NA,1.28804840845689,0.0292235860951597,1.53426649183163,0.91081598550184,Inf,0.0296198560706035,"lineage4","dr_mutations_pyrazinamide","GLU",0,"SRR7517794","SRR7517794","lineage4.1","ci","Ivory_Coast","pnca_p.ala146glu","A","H","ALA","AA146","pnca_complex.pdb"
|
|
"A146E","L2","PZA","A","A146",146,"E",NA,"XDR","DM","hydrophobic","hydrophilic","non-polar","acidic","non-polar","neg",14.858,0.284,-2.184,3.30206,-5.327,-0.93,75,85,-0.895,8,8,0,0,"helix",0.833333333333333,7.08,0.0001437401178668,19.411022297013,511754.463553649,Inf,4.73122070382274,-36,-46,0,-2,-44,0,0,0,0,0,0,-2,0,0,0,0,0,-6,0,-2,-7,-10,0,-8,-9,0.127354260089686,-0.564341085271318,0.120268212909476,-0.908269394714407,-0.243455497382199,0.789473684210526,-0.737232289950577,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","147/150","G:S:A",13.1456002256226,0.924803768447062,139.277183326707,0.0943844491368447,0.0001628371344419,NA,1.28804840845689,0.0292235860951597,1.53426649183163,0.91081598550184,Inf,0.0296198560706035,"lineage2","dr_mutations_pyrazinamide","GLU",0,"SAMN02628485","SRR1172091_SRR1183088_SRR1172034_SRR1180166","lineage2.2.1","ir","Iran","pnca_p.ala146glu","A","H","ALA","AA146","pnca_complex.pdb"
|
|
"A146E","L4","PZA","A","A146",146,"E",1,"MDR","DM","hydrophobic","hydrophilic","non-polar","acidic","non-polar","neg",14.858,0.284,-2.184,3.30206,-5.327,-0.93,75,85,-0.895,8,8,0,0,"helix",0.833333333333333,7.08,0.0001437401178668,19.411022297013,511754.463553649,Inf,4.73122070382274,-36,-46,0,-2,-44,0,0,0,0,0,0,-2,0,0,0,0,0,-6,0,-2,-7,-10,0,-8,-9,0.127354260089686,-0.564341085271318,0.120268212909476,-0.908269394714407,-0.243455497382199,0.789473684210526,-0.737232289950577,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","147/150","G:S:A",13.1456002256226,0.924803768447062,139.277183326707,0.0943844491368447,0.0001628371344419,NA,1.28804840845689,0.0292235860951597,1.53426649183163,0.91081598550184,Inf,0.0296198560706035,"lineage4","dr_mutations_pyrazinamide","GLU",0,"10350-03,ERR551807","ERR551807","lineage4.1.2.1","","","pnca_p.ala146glu","A","H","ALA","AA146","pnca_complex.pdb"
|
|
"A146E","L4","PZA","A","A146",146,"E",NA,"MDR","DM","hydrophobic","hydrophilic","non-polar","acidic","non-polar","neg",14.858,0.284,-2.184,3.30206,-5.327,-0.93,75,85,-0.895,8,8,0,0,"helix",0.833333333333333,7.08,0.0001437401178668,19.411022297013,511754.463553649,Inf,4.73122070382274,-36,-46,0,-2,-44,0,0,0,0,0,0,-2,0,0,0,0,0,-6,0,-2,-7,-10,0,-8,-9,0.127354260089686,-0.564341085271318,0.120268212909476,-0.908269394714407,-0.243455497382199,0.789473684210526,-0.737232289950577,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","147/150","G:S:A",13.1456002256226,0.924803768447062,139.277183326707,0.0943844491368447,0.0001628371344419,NA,1.28804840845689,0.0292235860951597,1.53426649183163,0.91081598550184,Inf,0.0296198560706035,"lineage4","dr_mutations_pyrazinamide","GLU",0,"SRS935943,SAMN03653318","SRR2024901","lineage4.4.2","cn","China","pnca_p.ala146glu","A","H","ALA","AA146","pnca_complex.pdb"
|
|
"A146E","L4","PZA","A","A146",146,"E",NA,"MDR","DM","hydrophobic","hydrophilic","non-polar","acidic","non-polar","neg",14.858,0.284,-2.184,3.30206,-5.327,-0.93,75,85,-0.895,8,8,0,0,"helix",0.833333333333333,7.08,0.0001437401178668,19.411022297013,511754.463553649,Inf,4.73122070382274,-36,-46,0,-2,-44,0,0,0,0,0,0,-2,0,0,0,0,0,-6,0,-2,-7,-10,0,-8,-9,0.127354260089686,-0.564341085271318,0.120268212909476,-0.908269394714407,-0.243455497382199,0.789473684210526,-0.737232289950577,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","147/150","G:S:A",13.1456002256226,0.924803768447062,139.277183326707,0.0943844491368447,0.0001628371344419,NA,1.28804840845689,0.0292235860951597,1.53426649183163,0.91081598550184,Inf,0.0296198560706035,"lineage4","dr_mutations_pyrazinamide","GLU",0,"SAMN03653313,SRS935924","SRR2024896","lineage4.4.2","cn","China","pnca_p.ala146glu","A","H","ALA","AA146","pnca_complex.pdb"
|
|
"A146E","L4","PZA","A","A146",146,"E",1,"Pre-XDR","DM","hydrophobic","hydrophilic","non-polar","acidic","non-polar","neg",14.858,0.284,-2.184,3.30206,-5.327,-0.93,75,85,-0.895,8,8,0,0,"helix",0.833333333333333,7.08,0.0001437401178668,19.411022297013,511754.463553649,Inf,4.73122070382274,-36,-46,0,-2,-44,0,0,0,0,0,0,-2,0,0,0,0,0,-6,0,-2,-7,-10,0,-8,-9,0.127354260089686,-0.564341085271318,0.120268212909476,-0.908269394714407,-0.243455497382199,0.789473684210526,-0.737232289950577,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","147/150","G:S:A",13.1456002256226,0.924803768447062,139.277183326707,0.0943844491368447,0.0001628371344419,NA,1.28804840845689,0.0292235860951597,1.53426649183163,0.91081598550184,Inf,0.0296198560706035,"lineage4","dr_mutations_pyrazinamide","GLU",0,"ERR2510880","ERR2510880","lineage4.2.1","it","Italy","pnca_p.ala146glu","A","H","ALA","AA146","pnca_complex.pdb"
|
|
"A146E","L2","PZA","A","A146",146,"E",NA,"XDR","DM","hydrophobic","hydrophilic","non-polar","acidic","non-polar","neg",14.858,0.284,-2.184,3.30206,-5.327,-0.93,75,85,-0.895,8,8,0,0,"helix",0.833333333333333,7.08,0.0001437401178668,19.411022297013,511754.463553649,Inf,4.73122070382274,-36,-46,0,-2,-44,0,0,0,0,0,0,-2,0,0,0,0,0,-6,0,-2,-7,-10,0,-8,-9,0.127354260089686,-0.564341085271318,0.120268212909476,-0.908269394714407,-0.243455497382199,0.789473684210526,-0.737232289950577,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","147/150","G:S:A",13.1456002256226,0.924803768447062,139.277183326707,0.0943844491368447,0.0001628371344419,NA,1.28804840845689,0.0292235860951597,1.53426649183163,0.91081598550184,Inf,0.0296198560706035,"lineage2","dr_mutations_pyrazinamide","GLU",0,"SAMN02628483","SRR1173684_SRR1174328","lineage2.2.1","ir","Iran","pnca_p.ala146glu","A","H","ALA","AA146","pnca_complex.pdb"
|
|
"A146E","L2","PZA","A","A146",146,"E",NA,"XDR","DM","hydrophobic","hydrophilic","non-polar","acidic","non-polar","neg",14.858,0.284,-2.184,3.30206,-5.327,-0.93,75,85,-0.895,8,8,0,0,"helix",0.833333333333333,7.08,0.0001437401178668,19.411022297013,511754.463553649,Inf,4.73122070382274,-36,-46,0,-2,-44,0,0,0,0,0,0,-2,0,0,0,0,0,-6,0,-2,-7,-10,0,-8,-9,0.127354260089686,-0.564341085271318,0.120268212909476,-0.908269394714407,-0.243455497382199,0.789473684210526,-0.737232289950577,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","147/150","G:S:A",13.1456002256226,0.924803768447062,139.277183326707,0.0943844491368447,0.0001628371344419,NA,1.28804840845689,0.0292235860951597,1.53426649183163,0.91081598550184,Inf,0.0296198560706035,"lineage2","dr_mutations_pyrazinamide","GLU",0,"SAMN02628484","SRR1173868_SRR1173347","lineage2.2.1","ir","Iran","pnca_p.ala146glu","A","H","ALA","AA146","pnca_complex.pdb"
|
|
"A146P","L4","PZA","A","A146",146,"P",NA,"Pre-MDR","OM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",14.858,-1.497,-1.233,3.10964,-3.961,0.02,79,85,-0.895,8,8,0,0,"helix",0.833333333333333,7.08,7.18700589334483e-05,9.70142977291842,188179.926264681,Inf,0.763784339928386,0,0,0,0,0,0,0,0,0,2,2,-2,0,0,0,0,0,-1,4,-5,-4,-4,0,-2,-5,-0.379179331306991,-0.318604651162791,0.113259857662133,-0.67536231884058,0.0112359550561797,0.831578947368421,-0.737232289950577,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.993,-0.827,"9:8","147/150","G:S:A",12.1451538387267,0.919026337424242,119.468044436246,0.101660271548246,5.01153666061373e-06,NA,0.986835744238421,0.170978870202674,0.767057556984365,0.124324963210678,Inf,0.382146811758261,"lineage4","other_mutations_pyrazinamide","PRO",0,"NG70","ERR1679638","lineage4.6","ng","Nigeria","pnca_p.ala146pro","A","H","ALA","AA146","pnca_complex.pdb"
|
|
"A146P","L2","PZA","A","A146",146,"P",1,"MDR","OM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",14.858,-1.497,-1.233,3.10964,-3.961,0.02,79,85,-0.895,8,8,0,0,"helix",0.833333333333333,7.08,7.18700589334483e-05,9.70142977291842,188179.926264681,Inf,0.763784339928386,0,0,0,0,0,0,0,0,0,2,2,-2,0,0,0,0,0,-1,4,-5,-4,-4,0,-2,-5,-0.379179331306991,-0.318604651162791,0.113259857662133,-0.67536231884058,0.0112359550561797,0.831578947368421,-0.737232289950577,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.993,-0.827,"9:8","147/150","G:S:A",12.1451538387267,0.919026337424242,119.468044436246,0.101660271548246,5.01153666061373e-06,NA,0.986835744238421,0.170978870202674,0.767057556984365,0.124324963210678,Inf,0.382146811758261,"lineage2","other_mutations_pyrazinamide","PRO",0,"ERR133970,0906L-sc-2012-02-09T18:57:30Z-1355303","ERR133970","lineage2.2.1","ru","Russia","pnca_p.ala146pro","A","H","ALA","AA146","pnca_complex.pdb"
|
|
"A146P","L2","PZA","A","A146",146,"P",NA,"MDR","OM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",14.858,-1.497,-1.233,3.10964,-3.961,0.02,79,85,-0.895,8,8,0,0,"helix",0.833333333333333,7.08,7.18700589334483e-05,9.70142977291842,188179.926264681,Inf,0.763784339928386,0,0,0,0,0,0,0,0,0,2,2,-2,0,0,0,0,0,-1,4,-5,-4,-4,0,-2,-5,-0.379179331306991,-0.318604651162791,0.113259857662133,-0.67536231884058,0.0112359550561797,0.831578947368421,-0.737232289950577,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",-0.993,-0.827,"9:8","147/150","G:S:A",12.1451538387267,0.919026337424242,119.468044436246,0.101660271548246,5.01153666061373e-06,NA,0.986835744238421,0.170978870202674,0.767057556984365,0.124324963210678,Inf,0.382146811758261,"lineage2","other_mutations_pyrazinamide","PRO",0,"0926H-sc-2011-10-12T14:59:48Z-1289193,ERR117459","ERR117459","lineage2.2.1","ru","Russia","pnca_p.ala146pro","A","H","ALA","AA146","pnca_complex.pdb"
|
|
"A146T","L4","PZA","A","A146",146,"T",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",14.858,-0.252,-2.074,1.48094,-2.71,-1.44,53,75,-0.895,8,8,0,0,"helix",0.833333333333333,7.08,0.0007187005893344,7.28887484197219,7.28887438834092,7.28728068125885,10.1421736186998,0,0,0,0,0,0,0,0,0,-2,0,-4,0,0,0,0,0,-5,0,-1,-4,-6,0,-2,-7,-0.0638297872340425,-0.535917312661499,0.053939058413887,-0.462063086104007,-0.37696335078534,0.557894736842105,-0.737232289950577,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","147/150","G:S:A",1.9863491292074,0.0021008470164788,0.645842738542518,3.07559257179235,2.08051219809968,28.5295272509804,0.862660492976905,0.0027830995390782,2.55547126060833,1.72659076531017,35.1741774538487,0.0014491518456837,"lineage4","dr_mutations_pyrazinamide","THR",0,"SRR3724799","SRR3724799","lineage4.3.4.2.1","cd","DRC","pnca_p.ala146thr","A","H","ALA","AA146","pnca_complex.pdb"
|
|
"A146T","L2","PZA","A","A146",146,"T",0,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",14.858,-0.252,-2.074,1.48094,-2.71,-1.44,53,75,-0.895,8,8,0,0,"helix",0.833333333333333,7.08,0.0007187005893344,7.28887484197219,7.28887438834092,7.28728068125885,10.1421736186998,0,0,0,0,0,0,0,0,0,-2,0,-4,0,0,0,0,0,-5,0,-1,-4,-6,0,-2,-7,-0.0638297872340425,-0.535917312661499,0.053939058413887,-0.462063086104007,-0.37696335078534,0.557894736842105,-0.737232289950577,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","147/150","G:S:A",1.9863491292074,0.0021008470164788,0.645842738542518,3.07559257179235,2.08051219809968,28.5295272509804,0.862660492976905,0.0027830995390782,2.55547126060833,1.72659076531017,35.1741774538487,0.0014491518456837,"lineage2","dr_mutations_pyrazinamide","THR",0,"MDR_5102","SRR6824648","lineage2.2.1","cn","China: Huimin District, Huhhot City, Inner Mongolia Province","pnca_p.ala146thr","A","H","ALA","AA146","pnca_complex.pdb"
|
|
"A146T","L4","PZA","A","A146",146,"T",1,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",14.858,-0.252,-2.074,1.48094,-2.71,-1.44,53,75,-0.895,8,8,0,0,"helix",0.833333333333333,7.08,0.0007187005893344,7.28887484197219,7.28887438834092,7.28728068125885,10.1421736186998,0,0,0,0,0,0,0,0,0,-2,0,-4,0,0,0,0,0,-5,0,-1,-4,-6,0,-2,-7,-0.0638297872340425,-0.535917312661499,0.053939058413887,-0.462063086104007,-0.37696335078534,0.557894736842105,-0.737232289950577,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","147/150","G:S:A",1.9863491292074,0.0021008470164788,0.645842738542518,3.07559257179235,2.08051219809968,28.5295272509804,0.862660492976905,0.0027830995390782,2.55547126060833,1.72659076531017,35.1741774538487,0.0014491518456837,"lineage4","dr_mutations_pyrazinamide","THR",0,"ERR2510729","ERR2510729","lineage4.1.2.1","it","Italy","pnca_p.ala146thr","A","H","ALA","AA146","pnca_complex.pdb"
|
|
"A146T","L2","PZA","A","A146",146,"T",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",14.858,-0.252,-2.074,1.48094,-2.71,-1.44,53,75,-0.895,8,8,0,0,"helix",0.833333333333333,7.08,0.0007187005893344,7.28887484197219,7.28887438834092,7.28728068125885,10.1421736186998,0,0,0,0,0,0,0,0,0,-2,0,-4,0,0,0,0,0,-5,0,-1,-4,-6,0,-2,-7,-0.0638297872340425,-0.535917312661499,0.053939058413887,-0.462063086104007,-0.37696335078534,0.557894736842105,-0.737232289950577,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","147/150","G:S:A",1.9863491292074,0.0021008470164788,0.645842738542518,3.07559257179235,2.08051219809968,28.5295272509804,0.862660492976905,0.0027830995390782,2.55547126060833,1.72659076531017,35.1741774538487,0.0014491518456837,"lineage2","dr_mutations_pyrazinamide","THR",0,"SRS797132","SRR1723642","lineage2.2.1","cn","China:InnerMongolia","pnca_p.ala146thr","A","H","ALA","AA146","pnca_complex.pdb"
|
|
"A146T","L2","PZA","A","A146",146,"T",1,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",14.858,-0.252,-2.074,1.48094,-2.71,-1.44,53,75,-0.895,8,8,0,0,"helix",0.833333333333333,7.08,0.0007187005893344,7.28887484197219,7.28887438834092,7.28728068125885,10.1421736186998,0,0,0,0,0,0,0,0,0,-2,0,-4,0,0,0,0,0,-5,0,-1,-4,-6,0,-2,-7,-0.0638297872340425,-0.535917312661499,0.053939058413887,-0.462063086104007,-0.37696335078534,0.557894736842105,-0.737232289950577,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","147/150","G:S:A",1.9863491292074,0.0021008470164788,0.645842738542518,3.07559257179235,2.08051219809968,28.5295272509804,0.862660492976905,0.0027830995390782,2.55547126060833,1.72659076531017,35.1741774538487,0.0014491518456837,"lineage2","dr_mutations_pyrazinamide","THR",0,"MDR_5107","SRR6824653","lineage2.2.1","cn","China: Huimin District, Huhhot City, Inner Mongolia Province","pnca_p.ala146thr","A","H","ALA","AA146","pnca_complex.pdb"
|
|
"A146T","L4","PZA","A","A146",146,"T",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",14.858,-0.252,-2.074,1.48094,-2.71,-1.44,53,75,-0.895,8,8,0,0,"helix",0.833333333333333,7.08,0.0007187005893344,7.28887484197219,7.28887438834092,7.28728068125885,10.1421736186998,0,0,0,0,0,0,0,0,0,-2,0,-4,0,0,0,0,0,-5,0,-1,-4,-6,0,-2,-7,-0.0638297872340425,-0.535917312661499,0.053939058413887,-0.462063086104007,-0.37696335078534,0.557894736842105,-0.737232289950577,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","147/150","G:S:A",1.9863491292074,0.0021008470164788,0.645842738542518,3.07559257179235,2.08051219809968,28.5295272509804,0.862660492976905,0.0027830995390782,2.55547126060833,1.72659076531017,35.1741774538487,0.0014491518456837,"lineage4","dr_mutations_pyrazinamide","THR",0,"ERR1193763","ERR1193763","lineage4.3","np","Nepal","pnca_p.ala146thr","A","H","ALA","AA146","pnca_complex.pdb"
|
|
"A146T","L4","PZA","A","A146",146,"T",NA,"Pre-MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",14.858,-0.252,-2.074,1.48094,-2.71,-1.44,53,75,-0.895,8,8,0,0,"helix",0.833333333333333,7.08,0.0007187005893344,7.28887484197219,7.28887438834092,7.28728068125885,10.1421736186998,0,0,0,0,0,0,0,0,0,-2,0,-4,0,0,0,0,0,-5,0,-1,-4,-6,0,-2,-7,-0.0638297872340425,-0.535917312661499,0.053939058413887,-0.462063086104007,-0.37696335078534,0.557894736842105,-0.737232289950577,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","147/150","G:S:A",1.9863491292074,0.0021008470164788,0.645842738542518,3.07559257179235,2.08051219809968,28.5295272509804,0.862660492976905,0.0027830995390782,2.55547126060833,1.72659076531017,35.1741774538487,0.0014491518456837,"lineage4","dr_mutations_pyrazinamide","THR",0,"ERR2706941","ERR2706941","lineage4","cd","Democratic Republic of Congo","pnca_p.ala146thr","A","H","ALA","AA146","pnca_complex.pdb"
|
|
"A146T","L2","PZA","A","A146",146,"T",1,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",14.858,-0.252,-2.074,1.48094,-2.71,-1.44,53,75,-0.895,8,8,0,0,"helix",0.833333333333333,7.08,0.0007187005893344,7.28887484197219,7.28887438834092,7.28728068125885,10.1421736186998,0,0,0,0,0,0,0,0,0,-2,0,-4,0,0,0,0,0,-5,0,-1,-4,-6,0,-2,-7,-0.0638297872340425,-0.535917312661499,0.053939058413887,-0.462063086104007,-0.37696335078534,0.557894736842105,-0.737232289950577,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","147/150","G:S:A",1.9863491292074,0.0021008470164788,0.645842738542518,3.07559257179235,2.08051219809968,28.5295272509804,0.862660492976905,0.0027830995390782,2.55547126060833,1.72659076531017,35.1741774538487,0.0014491518456837,"lineage2","dr_mutations_pyrazinamide","THR",0,"MDR_16527","SRR6824567","lineage2.2.2","cn","China: Nanyang City, Henan Province","pnca_p.ala146thr","A","H","ALA","AA146","pnca_complex.pdb"
|
|
"A146T","L2","PZA","A","A146",146,"T",0,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",14.858,-0.252,-2.074,1.48094,-2.71,-1.44,53,75,-0.895,8,8,0,0,"helix",0.833333333333333,7.08,0.0007187005893344,7.28887484197219,7.28887438834092,7.28728068125885,10.1421736186998,0,0,0,0,0,0,0,0,0,-2,0,-4,0,0,0,0,0,-5,0,-1,-4,-6,0,-2,-7,-0.0638297872340425,-0.535917312661499,0.053939058413887,-0.462063086104007,-0.37696335078534,0.557894736842105,-0.737232289950577,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","147/150","G:S:A",1.9863491292074,0.0021008470164788,0.645842738542518,3.07559257179235,2.08051219809968,28.5295272509804,0.862660492976905,0.0027830995390782,2.55547126060833,1.72659076531017,35.1741774538487,0.0014491518456837,"lineage2","dr_mutations_pyrazinamide","THR",0,"ERR2516474","ERR2516474","lineage2.2.1","nl","Netherlands","pnca_p.ala146thr","A","H","ALA","AA146","pnca_complex.pdb"
|
|
"A146T","L2","PZA","A","A146",146,"T",0,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",14.858,-0.252,-2.074,1.48094,-2.71,-1.44,53,75,-0.895,8,8,0,0,"helix",0.833333333333333,7.08,0.0007187005893344,7.28887484197219,7.28887438834092,7.28728068125885,10.1421736186998,0,0,0,0,0,0,0,0,0,-2,0,-4,0,0,0,0,0,-5,0,-1,-4,-6,0,-2,-7,-0.0638297872340425,-0.535917312661499,0.053939058413887,-0.462063086104007,-0.37696335078534,0.557894736842105,-0.737232289950577,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","147/150","G:S:A",1.9863491292074,0.0021008470164788,0.645842738542518,3.07559257179235,2.08051219809968,28.5295272509804,0.862660492976905,0.0027830995390782,2.55547126060833,1.72659076531017,35.1741774538487,0.0014491518456837,"lineage2","dr_mutations_pyrazinamide","THR",0,"MDR_5105","SRR6824655","lineage2.2.1","cn","China: Huimin District, Huhhot City, Inner Mongolia Province","pnca_p.ala146thr","A","H","ALA","AA146","pnca_complex.pdb"
|
|
"A146T","L2","PZA","A","A146",146,"T",0,"XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",14.858,-0.252,-2.074,1.48094,-2.71,-1.44,53,75,-0.895,8,8,0,0,"helix",0.833333333333333,7.08,0.0007187005893344,7.28887484197219,7.28887438834092,7.28728068125885,10.1421736186998,0,0,0,0,0,0,0,0,0,-2,0,-4,0,0,0,0,0,-5,0,-1,-4,-6,0,-2,-7,-0.0638297872340425,-0.535917312661499,0.053939058413887,-0.462063086104007,-0.37696335078534,0.557894736842105,-0.737232289950577,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","147/150","G:S:A",1.9863491292074,0.0021008470164788,0.645842738542518,3.07559257179235,2.08051219809968,28.5295272509804,0.862660492976905,0.0027830995390782,2.55547126060833,1.72659076531017,35.1741774538487,0.0014491518456837,"lineage2","dr_mutations_pyrazinamide","THR",0,"SAMEA2297088,ERR400517,ERS389475","ERR400517","lineage2.2.1","gb","United Kingdom","pnca_p.ala146thr","A","H","ALA","AA146","pnca_complex.pdb"
|
|
"A146T","L2","PZA","A","A146",146,"T",1,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",14.858,-0.252,-2.074,1.48094,-2.71,-1.44,53,75,-0.895,8,8,0,0,"helix",0.833333333333333,7.08,0.0007187005893344,7.28887484197219,7.28887438834092,7.28728068125885,10.1421736186998,0,0,0,0,0,0,0,0,0,-2,0,-4,0,0,0,0,0,-5,0,-1,-4,-6,0,-2,-7,-0.0638297872340425,-0.535917312661499,0.053939058413887,-0.462063086104007,-0.37696335078534,0.557894736842105,-0.737232289950577,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","147/150","G:S:A",1.9863491292074,0.0021008470164788,0.645842738542518,3.07559257179235,2.08051219809968,28.5295272509804,0.862660492976905,0.0027830995390782,2.55547126060833,1.72659076531017,35.1741774538487,0.0014491518456837,"lineage2","dr_mutations_pyrazinamide","THR",0,"MDR_5149","SRR6824533","lineage2.2.1","cn","China: Huimin District, Huhhot City, Inner Mongolia Province","pnca_p.ala146thr","A","H","ALA","AA146","pnca_complex.pdb"
|
|
"A146T","L4","PZA","A","A146",146,"T",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",14.858,-0.252,-2.074,1.48094,-2.71,-1.44,53,75,-0.895,8,8,0,0,"helix",0.833333333333333,7.08,0.0007187005893344,7.28887484197219,7.28887438834092,7.28728068125885,10.1421736186998,0,0,0,0,0,0,0,0,0,-2,0,-4,0,0,0,0,0,-5,0,-1,-4,-6,0,-2,-7,-0.0638297872340425,-0.535917312661499,0.053939058413887,-0.462063086104007,-0.37696335078534,0.557894736842105,-0.737232289950577,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","147/150","G:S:A",1.9863491292074,0.0021008470164788,0.645842738542518,3.07559257179235,2.08051219809968,28.5295272509804,0.862660492976905,0.0027830995390782,2.55547126060833,1.72659076531017,35.1741774538487,0.0014491518456837,"lineage4","dr_mutations_pyrazinamide","THR",0,"ERR1465929","ERR1465929","lineage4.8","do","Dominican Republic","pnca_p.ala146thr","A","H","ALA","AA146","pnca_complex.pdb"
|
|
"A146T","L2","PZA","A","A146",146,"T",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",14.858,-0.252,-2.074,1.48094,-2.71,-1.44,53,75,-0.895,8,8,0,0,"helix",0.833333333333333,7.08,0.0007187005893344,7.28887484197219,7.28887438834092,7.28728068125885,10.1421736186998,0,0,0,0,0,0,0,0,0,-2,0,-4,0,0,0,0,0,-5,0,-1,-4,-6,0,-2,-7,-0.0638297872340425,-0.535917312661499,0.053939058413887,-0.462063086104007,-0.37696335078534,0.557894736842105,-0.737232289950577,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","147/150","G:S:A",1.9863491292074,0.0021008470164788,0.645842738542518,3.07559257179235,2.08051219809968,28.5295272509804,0.862660492976905,0.0027830995390782,2.55547126060833,1.72659076531017,35.1741774538487,0.0014491518456837,"lineage2","dr_mutations_pyrazinamide","THR",0,"SRS797130","SRR1723640","lineage2.2.1","cn","China:InnerMongolia","pnca_p.ala146thr","A","H","ALA","AA146","pnca_complex.pdb"
|
|
"A146T","L2","PZA","A","A146",146,"T",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",14.858,-0.252,-2.074,1.48094,-2.71,-1.44,53,75,-0.895,8,8,0,0,"helix",0.833333333333333,7.08,0.0007187005893344,7.28887484197219,7.28887438834092,7.28728068125885,10.1421736186998,0,0,0,0,0,0,0,0,0,-2,0,-4,0,0,0,0,0,-5,0,-1,-4,-6,0,-2,-7,-0.0638297872340425,-0.535917312661499,0.053939058413887,-0.462063086104007,-0.37696335078534,0.557894736842105,-0.737232289950577,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","147/150","G:S:A",1.9863491292074,0.0021008470164788,0.645842738542518,3.07559257179235,2.08051219809968,28.5295272509804,0.862660492976905,0.0027830995390782,2.55547126060833,1.72659076531017,35.1741774538487,0.0014491518456837,"lineage2","dr_mutations_pyrazinamide","THR",0,"BGI_M-xz06013,SRR671737","SRR671737","lineage2.2.1","cn","China","pnca_p.ala146thr","A","H","ALA","AA146","pnca_complex.pdb"
|
|
"A146T","L2","PZA","A","A146",146,"T",1,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",14.858,-0.252,-2.074,1.48094,-2.71,-1.44,53,75,-0.895,8,8,0,0,"helix",0.833333333333333,7.08,0.0007187005893344,7.28887484197219,7.28887438834092,7.28728068125885,10.1421736186998,0,0,0,0,0,0,0,0,0,-2,0,-4,0,0,0,0,0,-5,0,-1,-4,-6,0,-2,-7,-0.0638297872340425,-0.535917312661499,0.053939058413887,-0.462063086104007,-0.37696335078534,0.557894736842105,-0.737232289950577,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","147/150","G:S:A",1.9863491292074,0.0021008470164788,0.645842738542518,3.07559257179235,2.08051219809968,28.5295272509804,0.862660492976905,0.0027830995390782,2.55547126060833,1.72659076531017,35.1741774538487,0.0014491518456837,"lineage2","dr_mutations_pyrazinamide","THR",0,"non-MDR_5148","SRR6824317","lineage2.2.1","cn","China: Huimin District, Huhhot City, Inner Mongolia Province","pnca_p.ala146thr","A","H","ALA","AA146","pnca_complex.pdb"
|
|
"A146T","L2","PZA","A","A146",146,"T",1,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",14.858,-0.252,-2.074,1.48094,-2.71,-1.44,53,75,-0.895,8,8,0,0,"helix",0.833333333333333,7.08,0.0007187005893344,7.28887484197219,7.28887438834092,7.28728068125885,10.1421736186998,0,0,0,0,0,0,0,0,0,-2,0,-4,0,0,0,0,0,-5,0,-1,-4,-6,0,-2,-7,-0.0638297872340425,-0.535917312661499,0.053939058413887,-0.462063086104007,-0.37696335078534,0.557894736842105,-0.737232289950577,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","147/150","G:S:A",1.9863491292074,0.0021008470164788,0.645842738542518,3.07559257179235,2.08051219809968,28.5295272509804,0.862660492976905,0.0027830995390782,2.55547126060833,1.72659076531017,35.1741774538487,0.0014491518456837,"lineage2","dr_mutations_pyrazinamide","THR",0,"MDR_5128","SRR6824536","lineage2.2.1","cn","China: Huimin District, Huhhot City, Inner Mongolia Province","pnca_p.ala146thr","A","H","ALA","AA146","pnca_complex.pdb"
|
|
"A146T","L2","PZA","A","A146",146,"T",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",14.858,-0.252,-2.074,1.48094,-2.71,-1.44,53,75,-0.895,8,8,0,0,"helix",0.833333333333333,7.08,0.0007187005893344,7.28887484197219,7.28887438834092,7.28728068125885,10.1421736186998,0,0,0,0,0,0,0,0,0,-2,0,-4,0,0,0,0,0,-5,0,-1,-4,-6,0,-2,-7,-0.0638297872340425,-0.535917312661499,0.053939058413887,-0.462063086104007,-0.37696335078534,0.557894736842105,-0.737232289950577,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","147/150","G:S:A",1.9863491292074,0.0021008470164788,0.645842738542518,3.07559257179235,2.08051219809968,28.5295272509804,0.862660492976905,0.0027830995390782,2.55547126060833,1.72659076531017,35.1741774538487,0.0014491518456837,"lineage2","dr_mutations_pyrazinamide","THR",0,"SRS797131","SRR1723641","lineage2.2.1","cn","China:InnerMongolia","pnca_p.ala146thr","A","H","ALA","AA146","pnca_complex.pdb"
|
|
"A146T","L4","PZA","A","A146",146,"T",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",14.858,-0.252,-2.074,1.48094,-2.71,-1.44,53,75,-0.895,8,8,0,0,"helix",0.833333333333333,7.08,0.0007187005893344,7.28887484197219,7.28887438834092,7.28728068125885,10.1421736186998,0,0,0,0,0,0,0,0,0,-2,0,-4,0,0,0,0,0,-5,0,-1,-4,-6,0,-2,-7,-0.0638297872340425,-0.535917312661499,0.053939058413887,-0.462063086104007,-0.37696335078534,0.557894736842105,-0.737232289950577,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","147/150","G:S:A",1.9863491292074,0.0021008470164788,0.645842738542518,3.07559257179235,2.08051219809968,28.5295272509804,0.862660492976905,0.0027830995390782,2.55547126060833,1.72659076531017,35.1741774538487,0.0014491518456837,"lineage4","dr_mutations_pyrazinamide","THR",0,"ERR2707190","ERR2707190","lineage4.3.4.2.1","cd","Democratic Republic of Congo","pnca_p.ala146thr","A","H","ALA","AA146","pnca_complex.pdb"
|
|
"A146T","L2","PZA","A","A146",146,"T",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",14.858,-0.252,-2.074,1.48094,-2.71,-1.44,53,75,-0.895,8,8,0,0,"helix",0.833333333333333,7.08,0.0007187005893344,7.28887484197219,7.28887438834092,7.28728068125885,10.1421736186998,0,0,0,0,0,0,0,0,0,-2,0,-4,0,0,0,0,0,-5,0,-1,-4,-6,0,-2,-7,-0.0638297872340425,-0.535917312661499,0.053939058413887,-0.462063086104007,-0.37696335078534,0.557894736842105,-0.737232289950577,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","147/150","G:S:A",1.9863491292074,0.0021008470164788,0.645842738542518,3.07559257179235,2.08051219809968,28.5295272509804,0.862660492976905,0.0027830995390782,2.55547126060833,1.72659076531017,35.1741774538487,0.0014491518456837,"lineage2","dr_mutations_pyrazinamide","THR",0,"SRS797129","SRR1723639","lineage2.2.1","cn","China:InnerMongolia","pnca_p.ala146thr","A","H","ALA","AA146","pnca_complex.pdb"
|
|
"A146T","L2","PZA","A","A146",146,"T",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",14.858,-0.252,-2.074,1.48094,-2.71,-1.44,53,75,-0.895,8,8,0,0,"helix",0.833333333333333,7.08,0.0007187005893344,7.28887484197219,7.28887438834092,7.28728068125885,10.1421736186998,0,0,0,0,0,0,0,0,0,-2,0,-4,0,0,0,0,0,-5,0,-1,-4,-6,0,-2,-7,-0.0638297872340425,-0.535917312661499,0.053939058413887,-0.462063086104007,-0.37696335078534,0.557894736842105,-0.737232289950577,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","147/150","G:S:A",1.9863491292074,0.0021008470164788,0.645842738542518,3.07559257179235,2.08051219809968,28.5295272509804,0.862660492976905,0.0027830995390782,2.55547126060833,1.72659076531017,35.1741774538487,0.0014491518456837,"lineage2","dr_mutations_pyrazinamide","THR",0,"SRR6280209","SRR6280209","lineage2.2.1","cn","China","pnca_p.ala146thr","A","H","ALA","AA146","pnca_complex.pdb"
|
|
"A146V","L4","PZA","A","A146",146,"V",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",14.858,-1.712,-0.425,0.463909,-2.215,-0.75,63,80,-0.895,8,8,0,0,"helix",0.833333333333333,7.08,0.0010061808250682,63.3736263736264,63.3734135554618,63.3515540724066,51.5211006732107,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-9,0,-3,-8,-4,0,-2,-5,-0.433637284701115,-0.109819121447028,0.0168965755869434,-0.37766410912191,-0.196335078534031,0.663157894736842,-0.737232289950577,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","147/150","G:S:A",4.14904442894259,6.28168511875833e-05,1.03675010392783,4.0019715582603,12.6188969963258,1151.617862186,1.8019085590898,1.22416292455872e-09,8.91216077783748,9.50473092944164,2653.71554384332,7.08317026236427e-13,"lineage4","dr_mutations_pyrazinamide","VAL",0,"SAMN02567715","SRR1166171","lineage4.8","ro","Romania","pnca_p.ala146val","A","H","ALA","AA146","pnca_complex.pdb"
|
|
"A146V","L4","PZA","A","A146",146,"V",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",14.858,-1.712,-0.425,0.463909,-2.215,-0.75,63,80,-0.895,8,8,0,0,"helix",0.833333333333333,7.08,0.0010061808250682,63.3736263736264,63.3734135554618,63.3515540724066,51.5211006732107,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-9,0,-3,-8,-4,0,-2,-5,-0.433637284701115,-0.109819121447028,0.0168965755869434,-0.37766410912191,-0.196335078534031,0.663157894736842,-0.737232289950577,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","147/150","G:S:A",4.14904442894259,6.28168511875833e-05,1.03675010392783,4.0019715582603,12.6188969963258,1151.617862186,1.8019085590898,1.22416292455872e-09,8.91216077783748,9.50473092944164,2653.71554384332,7.08317026236427e-13,"lineage4","dr_mutations_pyrazinamide","VAL",0,"SRR7341645","SRR7341645","lineage4.8","ro","Romania","pnca_p.ala146val","A","H","ALA","AA146","pnca_complex.pdb"
|
|
"A146V","L4","PZA","A","A146",146,"V",1,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",14.858,-1.712,-0.425,0.463909,-2.215,-0.75,63,80,-0.895,8,8,0,0,"helix",0.833333333333333,7.08,0.0010061808250682,63.3736263736264,63.3734135554618,63.3515540724066,51.5211006732107,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-9,0,-3,-8,-4,0,-2,-5,-0.433637284701115,-0.109819121447028,0.0168965755869434,-0.37766410912191,-0.196335078534031,0.663157894736842,-0.737232289950577,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","147/150","G:S:A",4.14904442894259,6.28168511875833e-05,1.03675010392783,4.0019715582603,12.6188969963258,1151.617862186,1.8019085590898,1.22416292455872e-09,8.91216077783748,9.50473092944164,2653.71554384332,7.08317026236427e-13,"lineage4","dr_mutations_pyrazinamide","VAL",0,"ERR2516478","ERR2516478","lineage4.3.4.2","pe","Peru","pnca_p.ala146val","A","H","ALA","AA146","pnca_complex.pdb"
|
|
"A146V","L4","PZA","A","A146",146,"V",1,"MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",14.858,-1.712,-0.425,0.463909,-2.215,-0.75,63,80,-0.895,8,8,0,0,"helix",0.833333333333333,7.08,0.0010061808250682,63.3736263736264,63.3734135554618,63.3515540724066,51.5211006732107,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-9,0,-3,-8,-4,0,-2,-5,-0.433637284701115,-0.109819121447028,0.0168965755869434,-0.37766410912191,-0.196335078534031,0.663157894736842,-0.737232289950577,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","147/150","G:S:A",4.14904442894259,6.28168511875833e-05,1.03675010392783,4.0019715582603,12.6188969963258,1151.617862186,1.8019085590898,1.22416292455872e-09,8.91216077783748,9.50473092944164,2653.71554384332,7.08317026236427e-13,"lineage4","dr_mutations_pyrazinamide","VAL",0,"ERR2510685","ERR2510685","lineage4.8","it","Italy","pnca_p.ala146val","A","H","ALA","AA146","pnca_complex.pdb"
|
|
"A146V","L4","PZA","A","A146",146,"V",1,"MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",14.858,-1.712,-0.425,0.463909,-2.215,-0.75,63,80,-0.895,8,8,0,0,"helix",0.833333333333333,7.08,0.0010061808250682,63.3736263736264,63.3734135554618,63.3515540724066,51.5211006732107,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-9,0,-3,-8,-4,0,-2,-5,-0.433637284701115,-0.109819121447028,0.0168965755869434,-0.37766410912191,-0.196335078534031,0.663157894736842,-0.737232289950577,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","147/150","G:S:A",4.14904442894259,6.28168511875833e-05,1.03675010392783,4.0019715582603,12.6188969963258,1151.617862186,1.8019085590898,1.22416292455872e-09,8.91216077783748,9.50473092944164,2653.71554384332,7.08317026236427e-13,"lineage4","dr_mutations_pyrazinamide","VAL",0,"ERR2510832","ERR2510832","lineage4.8","it","Italy","pnca_p.ala146val","A","H","ALA","AA146","pnca_complex.pdb"
|
|
"A146V","L4","PZA","A","A146",146,"V",NA,"XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",14.858,-1.712,-0.425,0.463909,-2.215,-0.75,63,80,-0.895,8,8,0,0,"helix",0.833333333333333,7.08,0.0010061808250682,63.3736263736264,63.3734135554618,63.3515540724066,51.5211006732107,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-9,0,-3,-8,-4,0,-2,-5,-0.433637284701115,-0.109819121447028,0.0168965755869434,-0.37766410912191,-0.196335078534031,0.663157894736842,-0.737232289950577,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","147/150","G:S:A",4.14904442894259,6.28168511875833e-05,1.03675010392783,4.0019715582603,12.6188969963258,1151.617862186,1.8019085590898,1.22416292455872e-09,8.91216077783748,9.50473092944164,2653.71554384332,7.08317026236427e-13,"lineage4","dr_mutations_pyrazinamide","VAL",0,"SAMN02567723","SRR1166321","lineage4.8","ro","Romania","pnca_p.ala146val","A","H","ALA","AA146","pnca_complex.pdb"
|
|
"A146V","L2","PZA","A","A146",146,"V",1,"XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",14.858,-1.712,-0.425,0.463909,-2.215,-0.75,63,80,-0.895,8,8,0,0,"helix",0.833333333333333,7.08,0.0010061808250682,63.3736263736264,63.3734135554618,63.3515540724066,51.5211006732107,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-9,0,-3,-8,-4,0,-2,-5,-0.433637284701115,-0.109819121447028,0.0168965755869434,-0.37766410912191,-0.196335078534031,0.663157894736842,-0.737232289950577,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","147/150","G:S:A",4.14904442894259,6.28168511875833e-05,1.03675010392783,4.0019715582603,12.6188969963258,1151.617862186,1.8019085590898,1.22416292455872e-09,8.91216077783748,9.50473092944164,2653.71554384332,7.08317026236427e-13,"lineage2","dr_mutations_pyrazinamide","VAL",0,"ERR228062,2162B-sc-2012-10-11T13:38:48Z-1494226","ERR228062","lineage2.2.1","ru","Russia,Samara","pnca_p.ala146val","A","H","ALA","AA146","pnca_complex.pdb"
|
|
"A146V","L4","PZA","A","A146",146,"V",1,"MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",14.858,-1.712,-0.425,0.463909,-2.215,-0.75,63,80,-0.895,8,8,0,0,"helix",0.833333333333333,7.08,0.0010061808250682,63.3736263736264,63.3734135554618,63.3515540724066,51.5211006732107,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-9,0,-3,-8,-4,0,-2,-5,-0.433637284701115,-0.109819121447028,0.0168965755869434,-0.37766410912191,-0.196335078534031,0.663157894736842,-0.737232289950577,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","147/150","G:S:A",4.14904442894259,6.28168511875833e-05,1.03675010392783,4.0019715582603,12.6188969963258,1151.617862186,1.8019085590898,1.22416292455872e-09,8.91216077783748,9.50473092944164,2653.71554384332,7.08317026236427e-13,"lineage4","dr_mutations_pyrazinamide","VAL",0,"ERR2510706","ERR2510706","lineage4.8","it","Italy","pnca_p.ala146val","A","H","ALA","AA146","pnca_complex.pdb"
|
|
"A146V","L4","PZA","A","A146",146,"V",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",14.858,-1.712,-0.425,0.463909,-2.215,-0.75,63,80,-0.895,8,8,0,0,"helix",0.833333333333333,7.08,0.0010061808250682,63.3736263736264,63.3734135554618,63.3515540724066,51.5211006732107,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-9,0,-3,-8,-4,0,-2,-5,-0.433637284701115,-0.109819121447028,0.0168965755869434,-0.37766410912191,-0.196335078534031,0.663157894736842,-0.737232289950577,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","147/150","G:S:A",4.14904442894259,6.28168511875833e-05,1.03675010392783,4.0019715582603,12.6188969963258,1151.617862186,1.8019085590898,1.22416292455872e-09,8.91216077783748,9.50473092944164,2653.71554384332,7.08317026236427e-13,"lineage4","dr_mutations_pyrazinamide","VAL",0,"SRR7341697","SRR7341697","lineage4.8","ro","Romania","pnca_p.ala146val","A","H","ALA","AA146","pnca_complex.pdb"
|
|
"A146V","L2","PZA","A","A146",146,"V",0,"MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",14.858,-1.712,-0.425,0.463909,-2.215,-0.75,63,80,-0.895,8,8,0,0,"helix",0.833333333333333,7.08,0.0010061808250682,63.3736263736264,63.3734135554618,63.3515540724066,51.5211006732107,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-9,0,-3,-8,-4,0,-2,-5,-0.433637284701115,-0.109819121447028,0.0168965755869434,-0.37766410912191,-0.196335078534031,0.663157894736842,-0.737232289950577,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","147/150","G:S:A",4.14904442894259,6.28168511875833e-05,1.03675010392783,4.0019715582603,12.6188969963258,1151.617862186,1.8019085590898,1.22416292455872e-09,8.91216077783748,9.50473092944164,2653.71554384332,7.08317026236427e-13,"lineage2","dr_mutations_pyrazinamide","VAL",0,"MDR_27149","SRR6824547","lineage2.2.1","cn","China: Weiyang District, Xi'an City, Shaanxi Province","pnca_p.ala146val","A","H","ALA","AA146","pnca_complex.pdb"
|
|
"A146V","L4","PZA","A","A146",146,"V",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",14.858,-1.712,-0.425,0.463909,-2.215,-0.75,63,80,-0.895,8,8,0,0,"helix",0.833333333333333,7.08,0.0010061808250682,63.3736263736264,63.3734135554618,63.3515540724066,51.5211006732107,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-9,0,-3,-8,-4,0,-2,-5,-0.433637284701115,-0.109819121447028,0.0168965755869434,-0.37766410912191,-0.196335078534031,0.663157894736842,-0.737232289950577,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","147/150","G:S:A",4.14904442894259,6.28168511875833e-05,1.03675010392783,4.0019715582603,12.6188969963258,1151.617862186,1.8019085590898,1.22416292455872e-09,8.91216077783748,9.50473092944164,2653.71554384332,7.08317026236427e-13,"lineage4","dr_mutations_pyrazinamide","VAL",0,"SAMN02567720","SRR1166190","lineage4.8","ro","Romania","pnca_p.ala146val","A","H","ALA","AA146","pnca_complex.pdb"
|
|
"A146V","L2","PZA","A","A146",146,"V",NA,"Pre-MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",14.858,-1.712,-0.425,0.463909,-2.215,-0.75,63,80,-0.895,8,8,0,0,"helix",0.833333333333333,7.08,0.0010061808250682,63.3736263736264,63.3734135554618,63.3515540724066,51.5211006732107,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-9,0,-3,-8,-4,0,-2,-5,-0.433637284701115,-0.109819121447028,0.0168965755869434,-0.37766410912191,-0.196335078534031,0.663157894736842,-0.737232289950577,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","147/150","G:S:A",4.14904442894259,6.28168511875833e-05,1.03675010392783,4.0019715582603,12.6188969963258,1151.617862186,1.8019085590898,1.22416292455872e-09,8.91216077783748,9.50473092944164,2653.71554384332,7.08317026236427e-13,"lineage2","dr_mutations_pyrazinamide","VAL",0,"SRR5067438","SRR5067438","lineage2.2.1.1","vn","Vietnam","pnca_p.ala146val","A","H","ALA","AA146","pnca_complex.pdb"
|
|
"A146V","L4","PZA","A","A146",146,"V",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",14.858,-1.712,-0.425,0.463909,-2.215,-0.75,63,80,-0.895,8,8,0,0,"helix",0.833333333333333,7.08,0.0010061808250682,63.3736263736264,63.3734135554618,63.3515540724066,51.5211006732107,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-9,0,-3,-8,-4,0,-2,-5,-0.433637284701115,-0.109819121447028,0.0168965755869434,-0.37766410912191,-0.196335078534031,0.663157894736842,-0.737232289950577,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","147/150","G:S:A",4.14904442894259,6.28168511875833e-05,1.03675010392783,4.0019715582603,12.6188969963258,1151.617862186,1.8019085590898,1.22416292455872e-09,8.91216077783748,9.50473092944164,2653.71554384332,7.08317026236427e-13,"lineage4","dr_mutations_pyrazinamide","VAL",0,"SRR7341688","SRR7341688","lineage4.8","ro","Romania","pnca_p.ala146val","A","H","ALA","AA146","pnca_complex.pdb"
|
|
"A146V","L4","PZA","A","A146",146,"V",1,"XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",14.858,-1.712,-0.425,0.463909,-2.215,-0.75,63,80,-0.895,8,8,0,0,"helix",0.833333333333333,7.08,0.0010061808250682,63.3736263736264,63.3734135554618,63.3515540724066,51.5211006732107,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-9,0,-3,-8,-4,0,-2,-5,-0.433637284701115,-0.109819121447028,0.0168965755869434,-0.37766410912191,-0.196335078534031,0.663157894736842,-0.737232289950577,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","147/150","G:S:A",4.14904442894259,6.28168511875833e-05,1.03675010392783,4.0019715582603,12.6188969963258,1151.617862186,1.8019085590898,1.22416292455872e-09,8.91216077783748,9.50473092944164,2653.71554384332,7.08317026236427e-13,"lineage4","dr_mutations_pyrazinamide","VAL",0,"ERR2517008","ERR2517008","lineage4.8","gb","UK","pnca_p.ala146val","A","H","ALA","AA146","pnca_complex.pdb"
|
|
"A146V","L4","PZA","A","A146",146,"V",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",14.858,-1.712,-0.425,0.463909,-2.215,-0.75,63,80,-0.895,8,8,0,0,"helix",0.833333333333333,7.08,0.0010061808250682,63.3736263736264,63.3734135554618,63.3515540724066,51.5211006732107,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-9,0,-3,-8,-4,0,-2,-5,-0.433637284701115,-0.109819121447028,0.0168965755869434,-0.37766410912191,-0.196335078534031,0.663157894736842,-0.737232289950577,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","147/150","G:S:A",4.14904442894259,6.28168511875833e-05,1.03675010392783,4.0019715582603,12.6188969963258,1151.617862186,1.8019085590898,1.22416292455872e-09,8.91216077783748,9.50473092944164,2653.71554384332,7.08317026236427e-13,"lineage4","dr_mutations_pyrazinamide","VAL",0,"SRR7341666","SRR7341666","lineage4.8","ro","Romania","pnca_p.ala146val","A","H","ALA","AA146","pnca_complex.pdb"
|
|
"A146V","L4","PZA","A","A146",146,"V",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",14.858,-1.712,-0.425,0.463909,-2.215,-0.75,63,80,-0.895,8,8,0,0,"helix",0.833333333333333,7.08,0.0010061808250682,63.3736263736264,63.3734135554618,63.3515540724066,51.5211006732107,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-9,0,-3,-8,-4,0,-2,-5,-0.433637284701115,-0.109819121447028,0.0168965755869434,-0.37766410912191,-0.196335078534031,0.663157894736842,-0.737232289950577,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","147/150","G:S:A",4.14904442894259,6.28168511875833e-05,1.03675010392783,4.0019715582603,12.6188969963258,1151.617862186,1.8019085590898,1.22416292455872e-09,8.91216077783748,9.50473092944164,2653.71554384332,7.08317026236427e-13,"lineage4","dr_mutations_pyrazinamide","VAL",0,"SAMN02567714","SRR1166121","lineage4.8","ro","Romania","pnca_p.ala146val","A","H","ALA","AA146","pnca_complex.pdb"
|
|
"A146V","L4","PZA","A","A146",146,"V",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",14.858,-1.712,-0.425,0.463909,-2.215,-0.75,63,80,-0.895,8,8,0,0,"helix",0.833333333333333,7.08,0.0010061808250682,63.3736263736264,63.3734135554618,63.3515540724066,51.5211006732107,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-9,0,-3,-8,-4,0,-2,-5,-0.433637284701115,-0.109819121447028,0.0168965755869434,-0.37766410912191,-0.196335078534031,0.663157894736842,-0.737232289950577,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","147/150","G:S:A",4.14904442894259,6.28168511875833e-05,1.03675010392783,4.0019715582603,12.6188969963258,1151.617862186,1.8019085590898,1.22416292455872e-09,8.91216077783748,9.50473092944164,2653.71554384332,7.08317026236427e-13,"lineage4","dr_mutations_pyrazinamide","VAL",0,"SRR7341638","SRR7341638","lineage4.8","ro","Romania","pnca_p.ala146val","A","H","ALA","AA146","pnca_complex.pdb"
|
|
"A146V","L4","PZA","A","A146",146,"V",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",14.858,-1.712,-0.425,0.463909,-2.215,-0.75,63,80,-0.895,8,8,0,0,"helix",0.833333333333333,7.08,0.0010061808250682,63.3736263736264,63.3734135554618,63.3515540724066,51.5211006732107,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-9,0,-3,-8,-4,0,-2,-5,-0.433637284701115,-0.109819121447028,0.0168965755869434,-0.37766410912191,-0.196335078534031,0.663157894736842,-0.737232289950577,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","147/150","G:S:A",4.14904442894259,6.28168511875833e-05,1.03675010392783,4.0019715582603,12.6188969963258,1151.617862186,1.8019085590898,1.22416292455872e-09,8.91216077783748,9.50473092944164,2653.71554384332,7.08317026236427e-13,"lineage4","dr_mutations_pyrazinamide","VAL",0,"ERR2679271","ERR2679271","lineage4.6.2.2","","","pnca_p.ala146val","A","H","ALA","AA146","pnca_complex.pdb"
|
|
"A146V","L4","PZA","A","A146",146,"V",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",14.858,-1.712,-0.425,0.463909,-2.215,-0.75,63,80,-0.895,8,8,0,0,"helix",0.833333333333333,7.08,0.0010061808250682,63.3736263736264,63.3734135554618,63.3515540724066,51.5211006732107,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-9,0,-3,-8,-4,0,-2,-5,-0.433637284701115,-0.109819121447028,0.0168965755869434,-0.37766410912191,-0.196335078534031,0.663157894736842,-0.737232289950577,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","147/150","G:S:A",4.14904442894259,6.28168511875833e-05,1.03675010392783,4.0019715582603,12.6188969963258,1151.617862186,1.8019085590898,1.22416292455872e-09,8.91216077783748,9.50473092944164,2653.71554384332,7.08317026236427e-13,"lineage4","dr_mutations_pyrazinamide","VAL",0,"SRR7341642","SRR7341642","lineage4.8","ro","Romania","pnca_p.ala146val","A","H","ALA","AA146","pnca_complex.pdb"
|
|
"A146V","L4","PZA","A","A146",146,"V",1,"MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",14.858,-1.712,-0.425,0.463909,-2.215,-0.75,63,80,-0.895,8,8,0,0,"helix",0.833333333333333,7.08,0.0010061808250682,63.3736263736264,63.3734135554618,63.3515540724066,51.5211006732107,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-9,0,-3,-8,-4,0,-2,-5,-0.433637284701115,-0.109819121447028,0.0168965755869434,-0.37766410912191,-0.196335078534031,0.663157894736842,-0.737232289950577,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","147/150","G:S:A",4.14904442894259,6.28168511875833e-05,1.03675010392783,4.0019715582603,12.6188969963258,1151.617862186,1.8019085590898,1.22416292455872e-09,8.91216077783748,9.50473092944164,2653.71554384332,7.08317026236427e-13,"lineage4","dr_mutations_pyrazinamide","VAL",0,"ERR2864236","ERR2864236","lineage4.3.4.1","pt","Portugal","pnca_p.ala146val","A","H","ALA","AA146","pnca_complex.pdb"
|
|
"A146V","L4","PZA","A","A146",146,"V",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",14.858,-1.712,-0.425,0.463909,-2.215,-0.75,63,80,-0.895,8,8,0,0,"helix",0.833333333333333,7.08,0.0010061808250682,63.3736263736264,63.3734135554618,63.3515540724066,51.5211006732107,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-9,0,-3,-8,-4,0,-2,-5,-0.433637284701115,-0.109819121447028,0.0168965755869434,-0.37766410912191,-0.196335078534031,0.663157894736842,-0.737232289950577,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","147/150","G:S:A",4.14904442894259,6.28168511875833e-05,1.03675010392783,4.0019715582603,12.6188969963258,1151.617862186,1.8019085590898,1.22416292455872e-09,8.91216077783748,9.50473092944164,2653.71554384332,7.08317026236427e-13,"lineage4","dr_mutations_pyrazinamide","VAL",0,"SRR7341696","SRR7341696","lineage4.8","ro","Romania","pnca_p.ala146val","A","H","ALA","AA146","pnca_complex.pdb"
|
|
"A146V","L4","PZA","A","A146",146,"V",1,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",14.858,-1.712,-0.425,0.463909,-2.215,-0.75,63,80,-0.895,8,8,0,0,"helix",0.833333333333333,7.08,0.0010061808250682,63.3736263736264,63.3734135554618,63.3515540724066,51.5211006732107,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-9,0,-3,-8,-4,0,-2,-5,-0.433637284701115,-0.109819121447028,0.0168965755869434,-0.37766410912191,-0.196335078534031,0.663157894736842,-0.737232289950577,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","147/150","G:S:A",4.14904442894259,6.28168511875833e-05,1.03675010392783,4.0019715582603,12.6188969963258,1151.617862186,1.8019085590898,1.22416292455872e-09,8.91216077783748,9.50473092944164,2653.71554384332,7.08317026236427e-13,"lineage4","dr_mutations_pyrazinamide","VAL",0,"ERR3335734","ERR3335734","lineage4","pk","Pakistan","pnca_p.ala146val","A","H","ALA","AA146","pnca_complex.pdb"
|
|
"A146V","L2","PZA","A","A146",146,"V",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",14.858,-1.712,-0.425,0.463909,-2.215,-0.75,63,80,-0.895,8,8,0,0,"helix",0.833333333333333,7.08,0.0010061808250682,63.3736263736264,63.3734135554618,63.3515540724066,51.5211006732107,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-9,0,-3,-8,-4,0,-2,-5,-0.433637284701115,-0.109819121447028,0.0168965755869434,-0.37766410912191,-0.196335078534031,0.663157894736842,-0.737232289950577,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","147/150","G:S:A",4.14904442894259,6.28168511875833e-05,1.03675010392783,4.0019715582603,12.6188969963258,1151.617862186,1.8019085590898,1.22416292455872e-09,8.91216077783748,9.50473092944164,2653.71554384332,7.08317026236427e-13,"lineage2","dr_mutations_pyrazinamide","VAL",0,"SRS796973","SRR1723461","lineage2.2.1","cn","China:Shaanxi","pnca_p.ala146val","A","H","ALA","AA146","pnca_complex.pdb"
|
|
"A146V","L4","PZA","A","A146",146,"V",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",14.858,-1.712,-0.425,0.463909,-2.215,-0.75,63,80,-0.895,8,8,0,0,"helix",0.833333333333333,7.08,0.0010061808250682,63.3736263736264,63.3734135554618,63.3515540724066,51.5211006732107,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-9,0,-3,-8,-4,0,-2,-5,-0.433637284701115,-0.109819121447028,0.0168965755869434,-0.37766410912191,-0.196335078534031,0.663157894736842,-0.737232289950577,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","147/150","G:S:A",4.14904442894259,6.28168511875833e-05,1.03675010392783,4.0019715582603,12.6188969963258,1151.617862186,1.8019085590898,1.22416292455872e-09,8.91216077783748,9.50473092944164,2653.71554384332,7.08317026236427e-13,"lineage4","dr_mutations_pyrazinamide","VAL",0,"SRR7341665","SRR7341665","lineage4.8","ro","Romania","pnca_p.ala146val","A","H","ALA","AA146","pnca_complex.pdb"
|
|
"A146V","L4","PZA","A","A146",146,"V",1,"MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",14.858,-1.712,-0.425,0.463909,-2.215,-0.75,63,80,-0.895,8,8,0,0,"helix",0.833333333333333,7.08,0.0010061808250682,63.3736263736264,63.3734135554618,63.3515540724066,51.5211006732107,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-9,0,-3,-8,-4,0,-2,-5,-0.433637284701115,-0.109819121447028,0.0168965755869434,-0.37766410912191,-0.196335078534031,0.663157894736842,-0.737232289950577,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","147/150","G:S:A",4.14904442894259,6.28168511875833e-05,1.03675010392783,4.0019715582603,12.6188969963258,1151.617862186,1.8019085590898,1.22416292455872e-09,8.91216077783748,9.50473092944164,2653.71554384332,7.08317026236427e-13,"lineage4","dr_mutations_pyrazinamide","VAL",0,"ERR2510657","ERR2510657","lineage4.8","it","Italy","pnca_p.ala146val","A","H","ALA","AA146","pnca_complex.pdb"
|
|
"A146V","L4","PZA","A","A146",146,"V",1,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",14.858,-1.712,-0.425,0.463909,-2.215,-0.75,63,80,-0.895,8,8,0,0,"helix",0.833333333333333,7.08,0.0010061808250682,63.3736263736264,63.3734135554618,63.3515540724066,51.5211006732107,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-9,0,-3,-8,-4,0,-2,-5,-0.433637284701115,-0.109819121447028,0.0168965755869434,-0.37766410912191,-0.196335078534031,0.663157894736842,-0.737232289950577,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","147/150","G:S:A",4.14904442894259,6.28168511875833e-05,1.03675010392783,4.0019715582603,12.6188969963258,1151.617862186,1.8019085590898,1.22416292455872e-09,8.91216077783748,9.50473092944164,2653.71554384332,7.08317026236427e-13,"lineage4","dr_mutations_pyrazinamide","VAL",0,"ERR2516463","ERR2516463","lineage4.3.4.2","pe","Peru","pnca_p.ala146val","A","H","ALA","AA146","pnca_complex.pdb"
|
|
"A146V","L4","PZA","A","A146",146,"V",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",14.858,-1.712,-0.425,0.463909,-2.215,-0.75,63,80,-0.895,8,8,0,0,"helix",0.833333333333333,7.08,0.0010061808250682,63.3736263736264,63.3734135554618,63.3515540724066,51.5211006732107,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-9,0,-3,-8,-4,0,-2,-5,-0.433637284701115,-0.109819121447028,0.0168965755869434,-0.37766410912191,-0.196335078534031,0.663157894736842,-0.737232289950577,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","147/150","G:S:A",4.14904442894259,6.28168511875833e-05,1.03675010392783,4.0019715582603,12.6188969963258,1151.617862186,1.8019085590898,1.22416292455872e-09,8.91216077783748,9.50473092944164,2653.71554384332,7.08317026236427e-13,"lineage4","dr_mutations_pyrazinamide","VAL",0,"SRR7341670","SRR7341670","lineage4.8","ro","Romania","pnca_p.ala146val","A","H","ALA","AA146","pnca_complex.pdb"
|
|
"A146V","L4","PZA","A","A146",146,"V",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",14.858,-1.712,-0.425,0.463909,-2.215,-0.75,63,80,-0.895,8,8,0,0,"helix",0.833333333333333,7.08,0.0010061808250682,63.3736263736264,63.3734135554618,63.3515540724066,51.5211006732107,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-9,0,-3,-8,-4,0,-2,-5,-0.433637284701115,-0.109819121447028,0.0168965755869434,-0.37766410912191,-0.196335078534031,0.663157894736842,-0.737232289950577,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","147/150","G:S:A",4.14904442894259,6.28168511875833e-05,1.03675010392783,4.0019715582603,12.6188969963258,1151.617862186,1.8019085590898,1.22416292455872e-09,8.91216077783748,9.50473092944164,2653.71554384332,7.08317026236427e-13,"lineage4","dr_mutations_pyrazinamide","VAL",0,"SRR7341662","SRR7341662","lineage4.8","ro","Romania","pnca_p.ala146val","A","H","ALA","AA146","pnca_complex.pdb"
|
|
"A146V","L4","PZA","A","A146",146,"V",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",14.858,-1.712,-0.425,0.463909,-2.215,-0.75,63,80,-0.895,8,8,0,0,"helix",0.833333333333333,7.08,0.0010061808250682,63.3736263736264,63.3734135554618,63.3515540724066,51.5211006732107,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-9,0,-3,-8,-4,0,-2,-5,-0.433637284701115,-0.109819121447028,0.0168965755869434,-0.37766410912191,-0.196335078534031,0.663157894736842,-0.737232289950577,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","147/150","G:S:A",4.14904442894259,6.28168511875833e-05,1.03675010392783,4.0019715582603,12.6188969963258,1151.617862186,1.8019085590898,1.22416292455872e-09,8.91216077783748,9.50473092944164,2653.71554384332,7.08317026236427e-13,"lineage4","dr_mutations_pyrazinamide","VAL",0,"SAMN02567698","SRR1175470","lineage4.8","ro","Romania","pnca_p.ala146val","A","H","ALA","AA146","pnca_complex.pdb"
|
|
"A146V","L4","PZA","A","A146",146,"V",1,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",14.858,-1.712,-0.425,0.463909,-2.215,-0.75,63,80,-0.895,8,8,0,0,"helix",0.833333333333333,7.08,0.0010061808250682,63.3736263736264,63.3734135554618,63.3515540724066,51.5211006732107,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-9,0,-3,-8,-4,0,-2,-5,-0.433637284701115,-0.109819121447028,0.0168965755869434,-0.37766410912191,-0.196335078534031,0.663157894736842,-0.737232289950577,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","147/150","G:S:A",4.14904442894259,6.28168511875833e-05,1.03675010392783,4.0019715582603,12.6188969963258,1151.617862186,1.8019085590898,1.22416292455872e-09,8.91216077783748,9.50473092944164,2653.71554384332,7.08317026236427e-13,"lineage4","dr_mutations_pyrazinamide","VAL",0,"ERR3335747","ERR3335747","lineage4","pk","Pakistan","pnca_p.ala146val","A","H","ALA","AA146","pnca_complex.pdb"
|
|
"A146V","L4","PZA","A","A146",146,"V",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",14.858,-1.712,-0.425,0.463909,-2.215,-0.75,63,80,-0.895,8,8,0,0,"helix",0.833333333333333,7.08,0.0010061808250682,63.3736263736264,63.3734135554618,63.3515540724066,51.5211006732107,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-9,0,-3,-8,-4,0,-2,-5,-0.433637284701115,-0.109819121447028,0.0168965755869434,-0.37766410912191,-0.196335078534031,0.663157894736842,-0.737232289950577,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","147/150","G:S:A",4.14904442894259,6.28168511875833e-05,1.03675010392783,4.0019715582603,12.6188969963258,1151.617862186,1.8019085590898,1.22416292455872e-09,8.91216077783748,9.50473092944164,2653.71554384332,7.08317026236427e-13,"lineage4","dr_mutations_pyrazinamide","VAL",0,"SRR7341679","SRR7341679","lineage4.8","ro","Romania","pnca_p.ala146val","A","H","ALA","AA146","pnca_complex.pdb"
|
|
"A146V","L2","PZA","A","A146",146,"V",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",14.858,-1.712,-0.425,0.463909,-2.215,-0.75,63,80,-0.895,8,8,0,0,"helix",0.833333333333333,7.08,0.0010061808250682,63.3736263736264,63.3734135554618,63.3515540724066,51.5211006732107,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-9,0,-3,-8,-4,0,-2,-5,-0.433637284701115,-0.109819121447028,0.0168965755869434,-0.37766410912191,-0.196335078534031,0.663157894736842,-0.737232289950577,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","147/150","G:S:A",4.14904442894259,6.28168511875833e-05,1.03675010392783,4.0019715582603,12.6188969963258,1151.617862186,1.8019085590898,1.22416292455872e-09,8.91216077783748,9.50473092944164,2653.71554384332,7.08317026236427e-13,"lineage2","dr_mutations_pyrazinamide","VAL",0,"SAMN02360608","SRR1049055_SRR1013659_SRR1049054_SRR1013658","lineage2.2.2","kr","South Korea","pnca_p.ala146val","A","H","ALA","AA146","pnca_complex.pdb"
|
|
"A146V","L4","PZA","A","A146",146,"V",1,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",14.858,-1.712,-0.425,0.463909,-2.215,-0.75,63,80,-0.895,8,8,0,0,"helix",0.833333333333333,7.08,0.0010061808250682,63.3736263736264,63.3734135554618,63.3515540724066,51.5211006732107,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-9,0,-3,-8,-4,0,-2,-5,-0.433637284701115,-0.109819121447028,0.0168965755869434,-0.37766410912191,-0.196335078534031,0.663157894736842,-0.737232289950577,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","147/150","G:S:A",4.14904442894259,6.28168511875833e-05,1.03675010392783,4.0019715582603,12.6188969963258,1151.617862186,1.8019085590898,1.22416292455872e-09,8.91216077783748,9.50473092944164,2653.71554384332,7.08317026236427e-13,"lineage4","dr_mutations_pyrazinamide","VAL",0,"ERR2516136","ERR2516136","lineage4.8","es","Spain","pnca_p.ala146val","A","H","ALA","AA146","pnca_complex.pdb"
|
|
"A146V","L4","PZA","A","A146",146,"V",1,"MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",14.858,-1.712,-0.425,0.463909,-2.215,-0.75,63,80,-0.895,8,8,0,0,"helix",0.833333333333333,7.08,0.0010061808250682,63.3736263736264,63.3734135554618,63.3515540724066,51.5211006732107,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-9,0,-3,-8,-4,0,-2,-5,-0.433637284701115,-0.109819121447028,0.0168965755869434,-0.37766410912191,-0.196335078534031,0.663157894736842,-0.737232289950577,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","147/150","G:S:A",4.14904442894259,6.28168511875833e-05,1.03675010392783,4.0019715582603,12.6188969963258,1151.617862186,1.8019085590898,1.22416292455872e-09,8.91216077783748,9.50473092944164,2653.71554384332,7.08317026236427e-13,"lineage4","dr_mutations_pyrazinamide","VAL",0,"ERR2510689","ERR2510689","lineage4.8","it","Italy","pnca_p.ala146val","A","H","ALA","AA146","pnca_complex.pdb"
|
|
"A146V","L4","PZA","A","A146",146,"V",NA,"XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",14.858,-1.712,-0.425,0.463909,-2.215,-0.75,63,80,-0.895,8,8,0,0,"helix",0.833333333333333,7.08,0.0010061808250682,63.3736263736264,63.3734135554618,63.3515540724066,51.5211006732107,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-9,0,-3,-8,-4,0,-2,-5,-0.433637284701115,-0.109819121447028,0.0168965755869434,-0.37766410912191,-0.196335078534031,0.663157894736842,-0.737232289950577,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","147/150","G:S:A",4.14904442894259,6.28168511875833e-05,1.03675010392783,4.0019715582603,12.6188969963258,1151.617862186,1.8019085590898,1.22416292455872e-09,8.91216077783748,9.50473092944164,2653.71554384332,7.08317026236427e-13,"lineage4","dr_mutations_pyrazinamide","VAL",0,"SAMN02567700","SRR1166094","lineage4.8","ro","Romania","pnca_p.ala146val","A","H","ALA","AA146","pnca_complex.pdb"
|
|
"A146V","L2","PZA","A","A146",146,"V",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",14.858,-1.712,-0.425,0.463909,-2.215,-0.75,63,80,-0.895,8,8,0,0,"helix",0.833333333333333,7.08,0.0010061808250682,63.3736263736264,63.3734135554618,63.3515540724066,51.5211006732107,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-9,0,-3,-8,-4,0,-2,-5,-0.433637284701115,-0.109819121447028,0.0168965755869434,-0.37766410912191,-0.196335078534031,0.663157894736842,-0.737232289950577,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","147/150","G:S:A",4.14904442894259,6.28168511875833e-05,1.03675010392783,4.0019715582603,12.6188969963258,1151.617862186,1.8019085590898,1.22416292455872e-09,8.91216077783748,9.50473092944164,2653.71554384332,7.08317026236427e-13,"lineage2","dr_mutations_pyrazinamide","VAL",0,"SRR5073998","SRR5073998","lineage2.2.1.1","vn","Vietnam","pnca_p.ala146val","A","H","ALA","AA146","pnca_complex.pdb"
|
|
"A146V","L4","PZA","A","A146",146,"V",NA,"XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",14.858,-1.712,-0.425,0.463909,-2.215,-0.75,63,80,-0.895,8,8,0,0,"helix",0.833333333333333,7.08,0.0010061808250682,63.3736263736264,63.3734135554618,63.3515540724066,51.5211006732107,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-9,0,-3,-8,-4,0,-2,-5,-0.433637284701115,-0.109819121447028,0.0168965755869434,-0.37766410912191,-0.196335078534031,0.663157894736842,-0.737232289950577,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","147/150","G:S:A",4.14904442894259,6.28168511875833e-05,1.03675010392783,4.0019715582603,12.6188969963258,1151.617862186,1.8019085590898,1.22416292455872e-09,8.91216077783748,9.50473092944164,2653.71554384332,7.08317026236427e-13,"lineage4","dr_mutations_pyrazinamide","VAL",0,"SRR7341687","SRR7341687","lineage4.8","ro","Romania","pnca_p.ala146val","A","H","ALA","AA146","pnca_complex.pdb"
|
|
"A146V","L4","PZA","A","A146",146,"V",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",14.858,-1.712,-0.425,0.463909,-2.215,-0.75,63,80,-0.895,8,8,0,0,"helix",0.833333333333333,7.08,0.0010061808250682,63.3736263736264,63.3734135554618,63.3515540724066,51.5211006732107,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-9,0,-3,-8,-4,0,-2,-5,-0.433637284701115,-0.109819121447028,0.0168965755869434,-0.37766410912191,-0.196335078534031,0.663157894736842,-0.737232289950577,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","147/150","G:S:A",4.14904442894259,6.28168511875833e-05,1.03675010392783,4.0019715582603,12.6188969963258,1151.617862186,1.8019085590898,1.22416292455872e-09,8.91216077783748,9.50473092944164,2653.71554384332,7.08317026236427e-13,"lineage4","dr_mutations_pyrazinamide","VAL",0,"SRR7341656","SRR7341656","lineage4.8","ro","Romania","pnca_p.ala146val","A","H","ALA","AA146","pnca_complex.pdb"
|
|
"A146V","L4","PZA","A","A146",146,"V",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",14.858,-1.712,-0.425,0.463909,-2.215,-0.75,63,80,-0.895,8,8,0,0,"helix",0.833333333333333,7.08,0.0010061808250682,63.3736263736264,63.3734135554618,63.3515540724066,51.5211006732107,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-9,0,-3,-8,-4,0,-2,-5,-0.433637284701115,-0.109819121447028,0.0168965755869434,-0.37766410912191,-0.196335078534031,0.663157894736842,-0.737232289950577,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","147/150","G:S:A",4.14904442894259,6.28168511875833e-05,1.03675010392783,4.0019715582603,12.6188969963258,1151.617862186,1.8019085590898,1.22416292455872e-09,8.91216077783748,9.50473092944164,2653.71554384332,7.08317026236427e-13,"lineage4","dr_mutations_pyrazinamide","VAL",0,"SAMN02567707","SRR1166130","lineage4.8","ro","Romania","pnca_p.ala146val","A","H","ALA","AA146","pnca_complex.pdb"
|
|
"A146V","L4","PZA","A","A146",146,"V",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",14.858,-1.712,-0.425,0.463909,-2.215,-0.75,63,80,-0.895,8,8,0,0,"helix",0.833333333333333,7.08,0.0010061808250682,63.3736263736264,63.3734135554618,63.3515540724066,51.5211006732107,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-9,0,-3,-8,-4,0,-2,-5,-0.433637284701115,-0.109819121447028,0.0168965755869434,-0.37766410912191,-0.196335078534031,0.663157894736842,-0.737232289950577,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","147/150","G:S:A",4.14904442894259,6.28168511875833e-05,1.03675010392783,4.0019715582603,12.6188969963258,1151.617862186,1.8019085590898,1.22416292455872e-09,8.91216077783748,9.50473092944164,2653.71554384332,7.08317026236427e-13,"lineage4","dr_mutations_pyrazinamide","VAL",0,"SRR7341677","SRR7341677","lineage4.8","ro","Romania","pnca_p.ala146val","A","H","ALA","AA146","pnca_complex.pdb"
|
|
"A146V","L4","PZA","A","A146",146,"V",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",14.858,-1.712,-0.425,0.463909,-2.215,-0.75,63,80,-0.895,8,8,0,0,"helix",0.833333333333333,7.08,0.0010061808250682,63.3736263736264,63.3734135554618,63.3515540724066,51.5211006732107,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-9,0,-3,-8,-4,0,-2,-5,-0.433637284701115,-0.109819121447028,0.0168965755869434,-0.37766410912191,-0.196335078534031,0.663157894736842,-0.737232289950577,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","147/150","G:S:A",4.14904442894259,6.28168511875833e-05,1.03675010392783,4.0019715582603,12.6188969963258,1151.617862186,1.8019085590898,1.22416292455872e-09,8.91216077783748,9.50473092944164,2653.71554384332,7.08317026236427e-13,"lineage4","dr_mutations_pyrazinamide","VAL",0,"SAMN02414911","SRR1146384_SRR1166818_SRR1144821_SRR1162814","lineage4.8","se","Sweden","pnca_p.ala146val","A","H","ALA","AA146","pnca_complex.pdb"
|
|
"R148C","L2","PZA","R","R148",148,"C",NA,"Pre-XDR","OM","hydrophilic","hydrophobic","basic","neutral","pos","non-polar",14.673,-0.94,-0.277,1.80299,-0.806,0.84,39,66,1.306,1,1,156,0.569343065693431,"helix",-1.26666666666667,3.5,NA,NA,NA,NA,NA,38,22,0,0,22,0,0,0,0,0,0,0,2,0,0,0,0,-3,0,-7,3,6,0,6,4,-0.238095238095238,-0.0715762273901808,0.0656688204313843,-0.137425404944587,0.47191011235955,0.410526315789474,0.418589743589744,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",0.842,1.712,"2:1","146/150","I:R:K:N:L:Q:E:H:W:D:M:S:A:G:T",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage2","other_mutations_pyrazinamide","CYS",0,"SAMN02414984","SRR1166878_SRR1162765_SRR1165490_SRR1165550","lineage2.2.1","se","Sweden","pnca_p.arg148cys","A","H","ARG","RA148","pnca_complex.pdb"
|
|
"R148C","L5","PZA","R","R148",148,"C",NA,"MDR","OM","hydrophilic","hydrophobic","basic","neutral","pos","non-polar",14.673,-0.94,-0.277,1.80299,-0.806,0.84,39,66,1.306,1,1,156,0.569343065693431,"helix",-1.26666666666667,3.5,NA,NA,NA,NA,NA,38,22,0,0,22,0,0,0,0,0,0,0,2,0,0,0,0,-3,0,-7,3,6,0,6,4,-0.238095238095238,-0.0715762273901808,0.0656688204313843,-0.137425404944587,0.47191011235955,0.410526315789474,0.418589743589744,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",0.842,1.712,"2:1","146/150","I:R:K:N:L:Q:E:H:W:D:M:S:A:G:T",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage5","other_mutations_pyrazinamide","CYS",0,"ERR2706914","ERR2706914","lineage5","cd","Democratic Republic of Congo","pnca_p.arg148cys","A","H","ARG","RA148","pnca_complex.pdb"
|
|
"R148C","L5","PZA","R","R148",148,"C",NA,"MDR","OM","hydrophilic","hydrophobic","basic","neutral","pos","non-polar",14.673,-0.94,-0.277,1.80299,-0.806,0.84,39,66,1.306,1,1,156,0.569343065693431,"helix",-1.26666666666667,3.5,NA,NA,NA,NA,NA,38,22,0,0,22,0,0,0,0,0,0,0,2,0,0,0,0,-3,0,-7,3,6,0,6,4,-0.238095238095238,-0.0715762273901808,0.0656688204313843,-0.137425404944587,0.47191011235955,0.410526315789474,0.418589743589744,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",0.842,1.712,"2:1","146/150","I:R:K:N:L:Q:E:H:W:D:M:S:A:G:T",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage5","other_mutations_pyrazinamide","CYS",0,"ERR2706930","ERR2706930","lineage5","cd","Democratic Republic of Congo","pnca_p.arg148cys","A","H","ARG","RA148","pnca_complex.pdb"
|
|
"N149D","L4","PZA","N","N149",149,"D",NA,"Sensitive","OM","hydrophilic","hydrophilic","neutral","acidic","polar","neg",16.469,-0.043,0.469,1.84951,-0.656,0.16,-34,66,0.97,1,1,71,0.364102564102564,"loop",-2.8,3.68,NA,NA,NA,NA,NA,0,-5,0,0,-5,0,0,0,0,0,0,2,0,0,0,0,0,0,0,0,0,0,0,0,2,-0.0108915906788247,0.398809523809524,0.0673631800930951,-0.111849957374254,0.0898876404494382,-0.365591397849462,0.310897435897436,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","neutral",0.59,1.183,"3:1","146/150","Q:E:Y:H:F:C:R:K:L:N:G:M:S:A:D",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage4","other_mutations_pyrazinamide","ASP",0,"SRR5065677","SRR5065677","lineage4.1.2.1","vn","Vietnam","pnca_p.asn149asp","A","T","ASN","NA149","pnca_complex.pdb"
|
|
"N149S","L2","PZA","N","N149",149,"S",NA,"Pre-MDR","OM","hydrophilic","hydrophilic","neutral","neutral","polar","polar",16.469,-0.233,-0.42,0.889156,-0.206,0.47,-76,87,0.97,1,1,71,0.364102564102564,"loop",-2.8,3.68,NA,NA,NA,NA,NA,18,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-0.0590172239108409,-0.108527131782946,0.0323849969769593,-0.0351236146632566,0.264044943820225,-0.817204301075269,0.310897435897436,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","neutral",0.59,1.183,"3:1","146/150","Q:E:Y:H:F:C:R:K:L:N:G:M:S:A:D",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage2","other_mutations_pyrazinamide","SER",0,"SRR5074122","SRR5074122","lineage2.2.2","vn","Vietnam","pnca_p.asn149ser","A","T","ASN","NA149","pnca_complex.pdb"
|
|
"N149V","L2","PZA","N","N149",149,"V",1,"Pre-XDR","OM","hydrophilic","hydrophobic","neutral","non-polar","polar","non-polar",16.469,-0.706,-0.064,0.446809,-0.317,-0.26,-28,61,0.97,1,1,71,0.364102564102564,"loop",-2.8,3.68,7.18700589334483e-05,9.70142977291842,188179.926264649,Inf,0.763784339928386,16,0,0,0,0,0,0,0,0,0,0,2,0,0,0,0,0,-3,0,-3,0,0,0,0,-2,-0.178824721377913,-0.0165374677002583,0.0162737563647754,-0.0540494458653026,-0.0680628272251308,-0.301075268817204,0.310897435897436,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","neutral",0.59,1.183,"3:1","146/150","Q:E:Y:H:F:C:R:K:L:N:G:M:S:A:D",12.1451538387265,0.919026337424236,119.468044436237,0.101660271548253,5.01153666062283e-06,NA,0.986835744238421,0.170978870202674,0.767057556984365,0.124324963210678,Inf,0.382146811758261,"lineage2","other_mutations_pyrazinamide","VAL",0,"MDR_12332","SRR6824501","lineage2.2.1","cn","China: Xuanzhou District, Xuancheng City, Anhui Province","pnca_p.asn149val","A","T","ASN","NA149","pnca_complex.pdb"
|
|
"N149V","L2","PZA","N","N149",149,"V",NA,"XDR","OM","hydrophilic","hydrophobic","neutral","non-polar","polar","non-polar",16.469,-0.706,-0.064,0.446809,-0.317,-0.26,-28,61,0.97,1,1,71,0.364102564102564,"loop",-2.8,3.68,7.18700589334483e-05,9.70142977291842,188179.926264649,Inf,0.763784339928386,16,0,0,0,0,0,0,0,0,0,0,2,0,0,0,0,0,-3,0,-3,0,0,0,0,-2,-0.178824721377913,-0.0165374677002583,0.0162737563647754,-0.0540494458653026,-0.0680628272251308,-0.301075268817204,0.310897435897436,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","neutral",0.59,1.183,"3:1","146/150","Q:E:Y:H:F:C:R:K:L:N:G:M:S:A:D",12.1451538387265,0.919026337424236,119.468044436237,0.101660271548253,5.01153666062283e-06,NA,0.986835744238421,0.170978870202674,0.767057556984365,0.124324963210678,Inf,0.382146811758261,"lineage2","other_mutations_pyrazinamide","VAL",0,"SRS797163","SRR1723676_SRR1723677","lineage2.2.1","cn","China:Anhui","pnca_p.asn149val","A","T","ASN","NA149","pnca_complex.pdb"
|
|
"G150D","L4","PZA","G","G150",150,"D",NA,"MDR","OM","hydrophobic","hydrophilic","neutral","acidic","non-polar","neg",21.16,1.269,-0.785,3.55888,-0.949,-0.34,51,75,-0.715,8,8,63,0.605769230769231,"loop",-0.0333333333333334,3.34,7.18700589334483e-05,9.70142977291842,188179.926264446,Inf,0.763784339928386,-12,-18,0,-2,-16,0,0,0,0,0,0,0,0,0,0,0,0,-1,0,-3,0,-2,0,-3,-9,0.569058295964126,-0.202842377260982,0.129622156338551,-0.161807331628303,-0.0890052356020942,0.536842105263158,-0.588962108731466,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.872,-0.615,"8:7","146/150","G:E:H:Q:L:D:R",12.1451538387254,0.9190263374242,119.468044436172,0.101660271548298,5.01153666068333e-06,NA,0.986835744238421,0.170978870202674,0.767057556984365,0.124324963210678,Inf,0.382146811758261,"lineage4","other_mutations_pyrazinamide","ASP",0,"ERR2179651","ERR2179651","lineage4.4.2","cn","China","pnca_p.gly150asp","A","T","GLY","GA150","pnca_complex.pdb"
|
|
"G150D","L4","PZA","G","G150",150,"D",1,"MDR","OM","hydrophobic","hydrophilic","neutral","acidic","non-polar","neg",21.16,1.269,-0.785,3.55888,-0.949,-0.34,51,75,-0.715,8,8,63,0.605769230769231,"loop",-0.0333333333333334,3.34,7.18700589334483e-05,9.70142977291842,188179.926264446,Inf,0.763784339928386,-12,-18,0,-2,-16,0,0,0,0,0,0,0,0,0,0,0,0,-1,0,-3,0,-2,0,-3,-9,0.569058295964126,-0.202842377260982,0.129622156338551,-0.161807331628303,-0.0890052356020942,0.536842105263158,-0.588962108731466,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.872,-0.615,"8:7","146/150","G:E:H:Q:L:D:R",12.1451538387254,0.9190263374242,119.468044436172,0.101660271548298,5.01153666068333e-06,NA,0.986835744238421,0.170978870202674,0.767057556984365,0.124324963210678,Inf,0.382146811758261,"lineage4","other_mutations_pyrazinamide","ASP",0,"MDR_11110","SRR6824683","lineage4.4.2","cn","China: Luqiao District, Taizhou City, Zhejiang Province","pnca_p.gly150asp","A","T","GLY","GA150","pnca_complex.pdb"
|
|
"G150D","L4","PZA","G","G150",150,"D",NA,"MDR","OM","hydrophobic","hydrophilic","neutral","acidic","non-polar","neg",21.16,1.269,-0.785,3.55888,-0.949,-0.34,51,75,-0.715,8,8,63,0.605769230769231,"loop",-0.0333333333333334,3.34,7.18700589334483e-05,9.70142977291842,188179.926264446,Inf,0.763784339928386,-12,-18,0,-2,-16,0,0,0,0,0,0,0,0,0,0,0,0,-1,0,-3,0,-2,0,-3,-9,0.569058295964126,-0.202842377260982,0.129622156338551,-0.161807331628303,-0.0890052356020942,0.536842105263158,-0.588962108731466,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.872,-0.615,"8:7","146/150","G:E:H:Q:L:D:R",12.1451538387254,0.9190263374242,119.468044436172,0.101660271548298,5.01153666068333e-06,NA,0.986835744238421,0.170978870202674,0.767057556984365,0.124324963210678,Inf,0.382146811758261,"lineage4","other_mutations_pyrazinamide","ASP",0,"SRS797443","SRR1723983","lineage4.4.2","cn","China:Zhejiang","pnca_p.gly150asp","A","T","GLY","GA150","pnca_complex.pdb"
|
|
"L151S","L4","PZA","L","L151",151,"S",NA,"MDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",18.507,0.079,-2.523,3.86505,-2.175,-2.07,57,75,-0.04,5,5,10,0.0497512437810945,"loop",1.73333333333333,5.31,0.0010061808250682,8.75696202531646,8.7569577260426,8.75484033225151,18.8086142562631,18,0,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,-3,0,-3,0,10,0,4,8,0.0354260089686098,-0.651937984496124,0.140773534189497,-0.370843989769821,-0.541884816753927,0.6,-0.0329489291598023,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.244,0.083,"6:5","145/150","Q:F:Y:I:R:L:V:M:W",2.16984855308098,0.0001010560982854,0.558082575591327,3.888042106998,3.02252426488638,28.523060095548,0.942353466387901,0.0001077244819236,3.96768558587492,2.63211458386555,33.2911283333248,1.44512946670157e-05,"lineage4","dr_mutations_pyrazinamide","SER",0,"SAMN02403582","SRR1169250_SRR1167347_SRR1165654_SRR1169315","lineage4.8","za","South Africa","pnca_p.leu151ser","A","-","LEU","LA151","pnca_complex.pdb"
|
|
"L151S","L4","PZA","L","L151",151,"S",NA,"MDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",18.507,0.079,-2.523,3.86505,-2.175,-2.07,57,75,-0.04,5,5,10,0.0497512437810945,"loop",1.73333333333333,5.31,0.0010061808250682,8.75696202531646,8.7569577260426,8.75484033225151,18.8086142562631,18,0,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,-3,0,-3,0,10,0,4,8,0.0354260089686098,-0.651937984496124,0.140773534189497,-0.370843989769821,-0.541884816753927,0.6,-0.0329489291598023,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.244,0.083,"6:5","145/150","Q:F:Y:I:R:L:V:M:W",2.16984855308098,0.0001010560982854,0.558082575591327,3.888042106998,3.02252426488638,28.523060095548,0.942353466387901,0.0001077244819236,3.96768558587492,2.63211458386555,33.2911283333248,1.44512946670157e-05,"lineage4","dr_mutations_pyrazinamide","SER",0,"SAMN02350463","SRR1140930_SRR1019137","lineage4.8","za","South Africa","pnca_p.leu151ser","A","-","LEU","LA151","pnca_complex.pdb"
|
|
"L151S","L4","PZA","L","L151",151,"S",NA,"MDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",18.507,0.079,-2.523,3.86505,-2.175,-2.07,57,75,-0.04,5,5,10,0.0497512437810945,"loop",1.73333333333333,5.31,0.0010061808250682,8.75696202531646,8.7569577260426,8.75484033225151,18.8086142562631,18,0,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,-3,0,-3,0,10,0,4,8,0.0354260089686098,-0.651937984496124,0.140773534189497,-0.370843989769821,-0.541884816753927,0.6,-0.0329489291598023,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.244,0.083,"6:5","145/150","Q:F:Y:I:R:L:V:M:W",2.16984855308098,0.0001010560982854,0.558082575591327,3.888042106998,3.02252426488638,28.523060095548,0.942353466387901,0.0001077244819236,3.96768558587492,2.63211458386555,33.2911283333248,1.44512946670157e-05,"lineage4","dr_mutations_pyrazinamide","SER",0,"SAMN02403554","SRR1169161_SRR1172067_SRR1165670_SRR1165680","lineage4.8","sz","Swaziland","pnca_p.leu151ser","A","-","LEU","LA151","pnca_complex.pdb"
|
|
"L151S","L4","PZA","L","L151",151,"S",NA,"MDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",18.507,0.079,-2.523,3.86505,-2.175,-2.07,57,75,-0.04,5,5,10,0.0497512437810945,"loop",1.73333333333333,5.31,0.0010061808250682,8.75696202531646,8.7569577260426,8.75484033225151,18.8086142562631,18,0,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,-3,0,-3,0,10,0,4,8,0.0354260089686098,-0.651937984496124,0.140773534189497,-0.370843989769821,-0.541884816753927,0.6,-0.0329489291598023,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.244,0.083,"6:5","145/150","Q:F:Y:I:R:L:V:M:W",2.16984855308098,0.0001010560982854,0.558082575591327,3.888042106998,3.02252426488638,28.523060095548,0.942353466387901,0.0001077244819236,3.96768558587492,2.63211458386555,33.2911283333248,1.44512946670157e-05,"lineage4","dr_mutations_pyrazinamide","SER",0,"SAMN02585993","SRR1172782_SRR1196517_SRR1184371_SRR1173081","lineage4.8","za","South Africa","pnca_p.leu151ser","A","-","LEU","LA151","pnca_complex.pdb"
|
|
"L151S","L4","PZA","L","L151",151,"S",1,"Pre-XDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",18.507,0.079,-2.523,3.86505,-2.175,-2.07,57,75,-0.04,5,5,10,0.0497512437810945,"loop",1.73333333333333,5.31,0.0010061808250682,8.75696202531646,8.7569577260426,8.75484033225151,18.8086142562631,18,0,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,-3,0,-3,0,10,0,4,8,0.0354260089686098,-0.651937984496124,0.140773534189497,-0.370843989769821,-0.541884816753927,0.6,-0.0329489291598023,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.244,0.083,"6:5","145/150","Q:F:Y:I:R:L:V:M:W",2.16984855308098,0.0001010560982854,0.558082575591327,3.888042106998,3.02252426488638,28.523060095548,0.942353466387901,0.0001077244819236,3.96768558587492,2.63211458386555,33.2911283333248,1.44512946670157e-05,"lineage4","dr_mutations_pyrazinamide","SER",0,"ERR551953","ERR551953","lineage4.8","sz","Swaziland","pnca_p.leu151ser","A","-","LEU","LA151","pnca_complex.pdb"
|
|
"L151S","L4","PZA","L","L151",151,"S",0,"MDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",18.507,0.079,-2.523,3.86505,-2.175,-2.07,57,75,-0.04,5,5,10,0.0497512437810945,"loop",1.73333333333333,5.31,0.0010061808250682,8.75696202531646,8.7569577260426,8.75484033225151,18.8086142562631,18,0,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,-3,0,-3,0,10,0,4,8,0.0354260089686098,-0.651937984496124,0.140773534189497,-0.370843989769821,-0.541884816753927,0.6,-0.0329489291598023,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.244,0.083,"6:5","145/150","Q:F:Y:I:R:L:V:M:W",2.16984855308098,0.0001010560982854,0.558082575591327,3.888042106998,3.02252426488638,28.523060095548,0.942353466387901,0.0001077244819236,3.96768558587492,2.63211458386555,33.2911283333248,1.44512946670157e-05,"lineage4","dr_mutations_pyrazinamide","SER",0,"ERR2515353","ERR2515353","lineage4.8","za","South Africa","pnca_p.leu151ser","A","-","LEU","LA151","pnca_complex.pdb"
|
|
"L151S","L4","PZA","L","L151",151,"S",NA,"MDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",18.507,0.079,-2.523,3.86505,-2.175,-2.07,57,75,-0.04,5,5,10,0.0497512437810945,"loop",1.73333333333333,5.31,0.0010061808250682,8.75696202531646,8.7569577260426,8.75484033225151,18.8086142562631,18,0,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,-3,0,-3,0,10,0,4,8,0.0354260089686098,-0.651937984496124,0.140773534189497,-0.370843989769821,-0.541884816753927,0.6,-0.0329489291598023,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.244,0.083,"6:5","145/150","Q:F:Y:I:R:L:V:M:W",2.16984855308098,0.0001010560982854,0.558082575591327,3.888042106998,3.02252426488638,28.523060095548,0.942353466387901,0.0001077244819236,3.96768558587492,2.63211458386555,33.2911283333248,1.44512946670157e-05,"lineage4","dr_mutations_pyrazinamide","SER",0,"SAMN02403597","SRR1172089_SRR1169169","lineage4.8","za","South Africa","pnca_p.leu151ser","A","-","LEU","LA151","pnca_complex.pdb"
|
|
"L151S","L4","PZA","L","L151",151,"S",0,"Pre-XDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",18.507,0.079,-2.523,3.86505,-2.175,-2.07,57,75,-0.04,5,5,10,0.0497512437810945,"loop",1.73333333333333,5.31,0.0010061808250682,8.75696202531646,8.7569577260426,8.75484033225151,18.8086142562631,18,0,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,-3,0,-3,0,10,0,4,8,0.0354260089686098,-0.651937984496124,0.140773534189497,-0.370843989769821,-0.541884816753927,0.6,-0.0329489291598023,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.244,0.083,"6:5","145/150","Q:F:Y:I:R:L:V:M:W",2.16984855308098,0.0001010560982854,0.558082575591327,3.888042106998,3.02252426488638,28.523060095548,0.942353466387901,0.0001077244819236,3.96768558587492,2.63211458386555,33.2911283333248,1.44512946670157e-05,"lineage4","dr_mutations_pyrazinamide","SER",0,"ERR2041729","ERR2041729","lineage4.2.2.1","rs","Serbia","pnca_p.leu151ser","A","-","LEU","LA151","pnca_complex.pdb"
|
|
"L151S","L4","PZA","L","L151",151,"S",NA,"MDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",18.507,0.079,-2.523,3.86505,-2.175,-2.07,57,75,-0.04,5,5,10,0.0497512437810945,"loop",1.73333333333333,5.31,0.0010061808250682,8.75696202531646,8.7569577260426,8.75484033225151,18.8086142562631,18,0,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,-3,0,-3,0,10,0,4,8,0.0354260089686098,-0.651937984496124,0.140773534189497,-0.370843989769821,-0.541884816753927,0.6,-0.0329489291598023,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.244,0.083,"6:5","145/150","Q:F:Y:I:R:L:V:M:W",2.16984855308098,0.0001010560982854,0.558082575591327,3.888042106998,3.02252426488638,28.523060095548,0.942353466387901,0.0001077244819236,3.96768558587492,2.63211458386555,33.2911283333248,1.44512946670157e-05,"lineage4","dr_mutations_pyrazinamide","SER",0,"SAMN02403529","SRR1165335_SRR1173424_SRR1173271_SRR1167278","lineage4.8","za","South Africa","pnca_p.leu151ser","A","-","LEU","LA151","pnca_complex.pdb"
|
|
"L151S","L4","PZA","L","L151",151,"S",1,"MDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",18.507,0.079,-2.523,3.86505,-2.175,-2.07,57,75,-0.04,5,5,10,0.0497512437810945,"loop",1.73333333333333,5.31,0.0010061808250682,8.75696202531646,8.7569577260426,8.75484033225151,18.8086142562631,18,0,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,-3,0,-3,0,10,0,4,8,0.0354260089686098,-0.651937984496124,0.140773534189497,-0.370843989769821,-0.541884816753927,0.6,-0.0329489291598023,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.244,0.083,"6:5","145/150","Q:F:Y:I:R:L:V:M:W",2.16984855308098,0.0001010560982854,0.558082575591327,3.888042106998,3.02252426488638,28.523060095548,0.942353466387901,0.0001077244819236,3.96768558587492,2.63211458386555,33.2911283333248,1.44512946670157e-05,"lineage4","dr_mutations_pyrazinamide","SER",0,"ERR2516070","ERR2516070","lineage4.8","za","South Africa","pnca_p.leu151ser","A","-","LEU","LA151","pnca_complex.pdb"
|
|
"L151S","L4","PZA","L","L151",151,"S",1,"MDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",18.507,0.079,-2.523,3.86505,-2.175,-2.07,57,75,-0.04,5,5,10,0.0497512437810945,"loop",1.73333333333333,5.31,0.0010061808250682,8.75696202531646,8.7569577260426,8.75484033225151,18.8086142562631,18,0,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,-3,0,-3,0,10,0,4,8,0.0354260089686098,-0.651937984496124,0.140773534189497,-0.370843989769821,-0.541884816753927,0.6,-0.0329489291598023,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.244,0.083,"6:5","145/150","Q:F:Y:I:R:L:V:M:W",2.16984855308098,0.0001010560982854,0.558082575591327,3.888042106998,3.02252426488638,28.523060095548,0.942353466387901,0.0001077244819236,3.96768558587492,2.63211458386555,33.2911283333248,1.44512946670157e-05,"lineage4","dr_mutations_pyrazinamide","SER",0,"ERR552415","ERR552415","lineage4.8","sz","Swaziland","pnca_p.leu151ser","A","-","LEU","LA151","pnca_complex.pdb"
|
|
"L151S","L2","PZA","L","L151",151,"S",0,"MDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",18.507,0.079,-2.523,3.86505,-2.175,-2.07,57,75,-0.04,5,5,10,0.0497512437810945,"loop",1.73333333333333,5.31,0.0010061808250682,8.75696202531646,8.7569577260426,8.75484033225151,18.8086142562631,18,0,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,-3,0,-3,0,10,0,4,8,0.0354260089686098,-0.651937984496124,0.140773534189497,-0.370843989769821,-0.541884816753927,0.6,-0.0329489291598023,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.244,0.083,"6:5","145/150","Q:F:Y:I:R:L:V:M:W",2.16984855308098,0.0001010560982854,0.558082575591327,3.888042106998,3.02252426488638,28.523060095548,0.942353466387901,0.0001077244819236,3.96768558587492,2.63211458386555,33.2911283333248,1.44512946670157e-05,"lineage2","dr_mutations_pyrazinamide","SER",0,"ERR2516718","ERR2516718","lineage2.2.1","nl","Netherlands","pnca_p.leu151ser","A","-","LEU","LA151","pnca_complex.pdb"
|
|
"L151S","L4","PZA","L","L151",151,"S",NA,"MDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",18.507,0.079,-2.523,3.86505,-2.175,-2.07,57,75,-0.04,5,5,10,0.0497512437810945,"loop",1.73333333333333,5.31,0.0010061808250682,8.75696202531646,8.7569577260426,8.75484033225151,18.8086142562631,18,0,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,-3,0,-3,0,10,0,4,8,0.0354260089686098,-0.651937984496124,0.140773534189497,-0.370843989769821,-0.541884816753927,0.6,-0.0329489291598023,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.244,0.083,"6:5","145/150","Q:F:Y:I:R:L:V:M:W",2.16984855308098,0.0001010560982854,0.558082575591327,3.888042106998,3.02252426488638,28.523060095548,0.942353466387901,0.0001077244819236,3.96768558587492,2.63211458386555,33.2911283333248,1.44512946670157e-05,"lineage4","dr_mutations_pyrazinamide","SER",0,"SAMN02403593","SRR1169205_SRR1165626_SRR1172260_SRR1167375","lineage4.8","za","South Africa","pnca_p.leu151ser","A","-","LEU","LA151","pnca_complex.pdb"
|
|
"L151S","L4","PZA","L","L151",151,"S",0,"MDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",18.507,0.079,-2.523,3.86505,-2.175,-2.07,57,75,-0.04,5,5,10,0.0497512437810945,"loop",1.73333333333333,5.31,0.0010061808250682,8.75696202531646,8.7569577260426,8.75484033225151,18.8086142562631,18,0,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,-3,0,-3,0,10,0,4,8,0.0354260089686098,-0.651937984496124,0.140773534189497,-0.370843989769821,-0.541884816753927,0.6,-0.0329489291598023,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.244,0.083,"6:5","145/150","Q:F:Y:I:R:L:V:M:W",2.16984855308098,0.0001010560982854,0.558082575591327,3.888042106998,3.02252426488638,28.523060095548,0.942353466387901,0.0001077244819236,3.96768558587492,2.63211458386555,33.2911283333248,1.44512946670157e-05,"lineage4","dr_mutations_pyrazinamide","SER",0,"ERR551289","ERR551289","lineage4.8","sz","Swaziland","pnca_p.leu151ser","A","-","LEU","LA151","pnca_complex.pdb"
|
|
"L151S","L2","PZA","L","L151",151,"S",NA,"MDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",18.507,0.079,-2.523,3.86505,-2.175,-2.07,57,75,-0.04,5,5,10,0.0497512437810945,"loop",1.73333333333333,5.31,0.0010061808250682,8.75696202531646,8.7569577260426,8.75484033225151,18.8086142562631,18,0,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,-3,0,-3,0,10,0,4,8,0.0354260089686098,-0.651937984496124,0.140773534189497,-0.370843989769821,-0.541884816753927,0.6,-0.0329489291598023,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.244,0.083,"6:5","145/150","Q:F:Y:I:R:L:V:M:W",2.16984855308098,0.0001010560982854,0.558082575591327,3.888042106998,3.02252426488638,28.523060095548,0.942353466387901,0.0001077244819236,3.96768558587492,2.63211458386555,33.2911283333248,1.44512946670157e-05,"lineage2","dr_mutations_pyrazinamide","SER",0,"SAMN02628489","SRR1173695_SRR1174314","lineage2.2.1","ir","Iran","pnca_p.leu151ser","A","-","LEU","LA151","pnca_complex.pdb"
|
|
"L151S","L4","PZA","L","L151",151,"S",1,"MDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",18.507,0.079,-2.523,3.86505,-2.175,-2.07,57,75,-0.04,5,5,10,0.0497512437810945,"loop",1.73333333333333,5.31,0.0010061808250682,8.75696202531646,8.7569577260426,8.75484033225151,18.8086142562631,18,0,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,-3,0,-3,0,10,0,4,8,0.0354260089686098,-0.651937984496124,0.140773534189497,-0.370843989769821,-0.541884816753927,0.6,-0.0329489291598023,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.244,0.083,"6:5","145/150","Q:F:Y:I:R:L:V:M:W",2.16984855308098,0.0001010560982854,0.558082575591327,3.888042106998,3.02252426488638,28.523060095548,0.942353466387901,0.0001077244819236,3.96768558587492,2.63211458386555,33.2911283333248,1.44512946670157e-05,"lineage4","dr_mutations_pyrazinamide","SER",0,"ERR552463","ERR552463","lineage4.8","sz","Swaziland","pnca_p.leu151ser","A","-","LEU","LA151","pnca_complex.pdb"
|
|
"L151S","L4","PZA","L","L151",151,"S",1,"XDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",18.507,0.079,-2.523,3.86505,-2.175,-2.07,57,75,-0.04,5,5,10,0.0497512437810945,"loop",1.73333333333333,5.31,0.0010061808250682,8.75696202531646,8.7569577260426,8.75484033225151,18.8086142562631,18,0,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,-3,0,-3,0,10,0,4,8,0.0354260089686098,-0.651937984496124,0.140773534189497,-0.370843989769821,-0.541884816753927,0.6,-0.0329489291598023,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.244,0.083,"6:5","145/150","Q:F:Y:I:R:L:V:M:W",2.16984855308098,0.0001010560982854,0.558082575591327,3.888042106998,3.02252426488638,28.523060095548,0.942353466387901,0.0001077244819236,3.96768558587492,2.63211458386555,33.2911283333248,1.44512946670157e-05,"lineage4","dr_mutations_pyrazinamide","SER",0,"ERR552809","ERR552809","lineage4.8","sz","Swaziland","pnca_p.leu151ser","A","-","LEU","LA151","pnca_complex.pdb"
|
|
"L151S","L4","PZA","L","L151",151,"S",NA,"MDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",18.507,0.079,-2.523,3.86505,-2.175,-2.07,57,75,-0.04,5,5,10,0.0497512437810945,"loop",1.73333333333333,5.31,0.0010061808250682,8.75696202531646,8.7569577260426,8.75484033225151,18.8086142562631,18,0,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,-3,0,-3,0,10,0,4,8,0.0354260089686098,-0.651937984496124,0.140773534189497,-0.370843989769821,-0.541884816753927,0.6,-0.0329489291598023,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.244,0.083,"6:5","145/150","Q:F:Y:I:R:L:V:M:W",2.16984855308098,0.0001010560982854,0.558082575591327,3.888042106998,3.02252426488638,28.523060095548,0.942353466387901,0.0001077244819236,3.96768558587492,2.63211458386555,33.2911283333248,1.44512946670157e-05,"lineage4","dr_mutations_pyrazinamide","SER",0,"SAMN02403594","SRR1172069_SRR1169003_SRR1165688_SRR1167355","lineage4.8","za","South Africa","pnca_p.leu151ser","A","-","LEU","LA151","pnca_complex.pdb"
|
|
"L151S","L4","PZA","L","L151",151,"S",NA,"MDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",18.507,0.079,-2.523,3.86505,-2.175,-2.07,57,75,-0.04,5,5,10,0.0497512437810945,"loop",1.73333333333333,5.31,0.0010061808250682,8.75696202531646,8.7569577260426,8.75484033225151,18.8086142562631,18,0,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,-3,0,-3,0,10,0,4,8,0.0354260089686098,-0.651937984496124,0.140773534189497,-0.370843989769821,-0.541884816753927,0.6,-0.0329489291598023,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.244,0.083,"6:5","145/150","Q:F:Y:I:R:L:V:M:W",2.16984855308098,0.0001010560982854,0.558082575591327,3.888042106998,3.02252426488638,28.523060095548,0.942353466387901,0.0001077244819236,3.96768558587492,2.63211458386555,33.2911283333248,1.44512946670157e-05,"lineage4","dr_mutations_pyrazinamide","SER",0,"ERR552780","ERR552780","lineage4.8","sz","Swaziland","pnca_p.leu151ser","A","-","LEU","LA151","pnca_complex.pdb"
|
|
"L151S","L4","PZA","L","L151",151,"S",1,"MDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",18.507,0.079,-2.523,3.86505,-2.175,-2.07,57,75,-0.04,5,5,10,0.0497512437810945,"loop",1.73333333333333,5.31,0.0010061808250682,8.75696202531646,8.7569577260426,8.75484033225151,18.8086142562631,18,0,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,-3,0,-3,0,10,0,4,8,0.0354260089686098,-0.651937984496124,0.140773534189497,-0.370843989769821,-0.541884816753927,0.6,-0.0329489291598023,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.244,0.083,"6:5","145/150","Q:F:Y:I:R:L:V:M:W",2.16984855308098,0.0001010560982854,0.558082575591327,3.888042106998,3.02252426488638,28.523060095548,0.942353466387901,0.0001077244819236,3.96768558587492,2.63211458386555,33.2911283333248,1.44512946670157e-05,"lineage4","dr_mutations_pyrazinamide","SER",0,"ERR2516043","ERR2516043","lineage4.8","za","South Africa","pnca_p.leu151ser","A","-","LEU","LA151","pnca_complex.pdb"
|
|
"L151S","L4","PZA","L","L151",151,"S",1,"MDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",18.507,0.079,-2.523,3.86505,-2.175,-2.07,57,75,-0.04,5,5,10,0.0497512437810945,"loop",1.73333333333333,5.31,0.0010061808250682,8.75696202531646,8.7569577260426,8.75484033225151,18.8086142562631,18,0,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,-3,0,-3,0,10,0,4,8,0.0354260089686098,-0.651937984496124,0.140773534189497,-0.370843989769821,-0.541884816753927,0.6,-0.0329489291598023,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.244,0.083,"6:5","145/150","Q:F:Y:I:R:L:V:M:W",2.16984855308098,0.0001010560982854,0.558082575591327,3.888042106998,3.02252426488638,28.523060095548,0.942353466387901,0.0001077244819236,3.96768558587492,2.63211458386555,33.2911283333248,1.44512946670157e-05,"lineage4","dr_mutations_pyrazinamide","SER",0,"ERR2041717","ERR2041717","lineage4.2.2.1","rs","Serbia","pnca_p.leu151ser","A","-","LEU","LA151","pnca_complex.pdb"
|
|
"L151S","L4","PZA","L","L151",151,"S",NA,"MDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",18.507,0.079,-2.523,3.86505,-2.175,-2.07,57,75,-0.04,5,5,10,0.0497512437810945,"loop",1.73333333333333,5.31,0.0010061808250682,8.75696202531646,8.7569577260426,8.75484033225151,18.8086142562631,18,0,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,-3,0,-3,0,10,0,4,8,0.0354260089686098,-0.651937984496124,0.140773534189497,-0.370843989769821,-0.541884816753927,0.6,-0.0329489291598023,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.244,0.083,"6:5","145/150","Q:F:Y:I:R:L:V:M:W",2.16984855308098,0.0001010560982854,0.558082575591327,3.888042106998,3.02252426488638,28.523060095548,0.942353466387901,0.0001077244819236,3.96768558587492,2.63211458386555,33.2911283333248,1.44512946670157e-05,"lineage4","dr_mutations_pyrazinamide","SER",0,"SAMN02586029","SRR1173033_SRR1173167","lineage4.8","za","South Africa","pnca_p.leu151ser","A","-","LEU","LA151","pnca_complex.pdb"
|
|
"L151S","L4","PZA","L","L151",151,"S",1,"MDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",18.507,0.079,-2.523,3.86505,-2.175,-2.07,57,75,-0.04,5,5,10,0.0497512437810945,"loop",1.73333333333333,5.31,0.0010061808250682,8.75696202531646,8.7569577260426,8.75484033225151,18.8086142562631,18,0,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,-3,0,-3,0,10,0,4,8,0.0354260089686098,-0.651937984496124,0.140773534189497,-0.370843989769821,-0.541884816753927,0.6,-0.0329489291598023,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.244,0.083,"6:5","145/150","Q:F:Y:I:R:L:V:M:W",2.16984855308098,0.0001010560982854,0.558082575591327,3.888042106998,3.02252426488638,28.523060095548,0.942353466387901,0.0001077244819236,3.96768558587492,2.63211458386555,33.2911283333248,1.44512946670157e-05,"lineage4","dr_mutations_pyrazinamide","SER",0,"SRR2101555,SAMN03648802","SRR2101555","lineage4.8","","","pnca_p.leu151ser","A","-","LEU","LA151","pnca_complex.pdb"
|
|
"L151S","L2","PZA","L","L151",151,"S",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",18.507,0.079,-2.523,3.86505,-2.175,-2.07,57,75,-0.04,5,5,10,0.0497512437810945,"loop",1.73333333333333,5.31,0.0010061808250682,8.75696202531646,8.7569577260426,8.75484033225151,18.8086142562631,18,0,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,-3,0,-3,0,10,0,4,8,0.0354260089686098,-0.651937984496124,0.140773534189497,-0.370843989769821,-0.541884816753927,0.6,-0.0329489291598023,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.244,0.083,"6:5","145/150","Q:F:Y:I:R:L:V:M:W",2.16984855308098,0.0001010560982854,0.558082575591327,3.888042106998,3.02252426488638,28.523060095548,0.942353466387901,0.0001077244819236,3.96768558587492,2.63211458386555,33.2911283333248,1.44512946670157e-05,"lineage2","dr_mutations_pyrazinamide","SER",0,"ERR552482","ERR552482","lineage2.2.1","","Abkhazia,Georgia","pnca_p.leu151ser","A","-","LEU","LA151","pnca_complex.pdb"
|
|
"L151S","L4","PZA","L","L151",151,"S",NA,"MDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",18.507,0.079,-2.523,3.86505,-2.175,-2.07,57,75,-0.04,5,5,10,0.0497512437810945,"loop",1.73333333333333,5.31,0.0010061808250682,8.75696202531646,8.7569577260426,8.75484033225151,18.8086142562631,18,0,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,-3,0,-3,0,10,0,4,8,0.0354260089686098,-0.651937984496124,0.140773534189497,-0.370843989769821,-0.541884816753927,0.6,-0.0329489291598023,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.244,0.083,"6:5","145/150","Q:F:Y:I:R:L:V:M:W",2.16984855308098,0.0001010560982854,0.558082575591327,3.888042106998,3.02252426488638,28.523060095548,0.942353466387901,0.0001077244819236,3.96768558587492,2.63211458386555,33.2911283333248,1.44512946670157e-05,"lineage4","dr_mutations_pyrazinamide","SER",0,"SAMN02403596","SRR1181049_SRR1180953","lineage4.8","za","South Africa","pnca_p.leu151ser","A","-","LEU","LA151","pnca_complex.pdb"
|
|
"L151S","L4","PZA","L","L151",151,"S",NA,"XDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",18.507,0.079,-2.523,3.86505,-2.175,-2.07,57,75,-0.04,5,5,10,0.0497512437810945,"loop",1.73333333333333,5.31,0.0010061808250682,8.75696202531646,8.7569577260426,8.75484033225151,18.8086142562631,18,0,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,-3,0,-3,0,10,0,4,8,0.0354260089686098,-0.651937984496124,0.140773534189497,-0.370843989769821,-0.541884816753927,0.6,-0.0329489291598023,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.244,0.083,"6:5","145/150","Q:F:Y:I:R:L:V:M:W",2.16984855308098,0.0001010560982854,0.558082575591327,3.888042106998,3.02252426488638,28.523060095548,0.942353466387901,0.0001077244819236,3.96768558587492,2.63211458386555,33.2911283333248,1.44512946670157e-05,"lineage4","dr_mutations_pyrazinamide","SER",0,"SAMN02586019","SRR1172749_SRR1196497_SRR1173120_SRR1184340","lineage4.8","za","South Africa","pnca_p.leu151ser","A","-","LEU","LA151","pnca_complex.pdb"
|
|
"L151S","L4","PZA","L","L151",151,"S",NA,"MDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",18.507,0.079,-2.523,3.86505,-2.175,-2.07,57,75,-0.04,5,5,10,0.0497512437810945,"loop",1.73333333333333,5.31,0.0010061808250682,8.75696202531646,8.7569577260426,8.75484033225151,18.8086142562631,18,0,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,-3,0,-3,0,10,0,4,8,0.0354260089686098,-0.651937984496124,0.140773534189497,-0.370843989769821,-0.541884816753927,0.6,-0.0329489291598023,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.244,0.083,"6:5","145/150","Q:F:Y:I:R:L:V:M:W",2.16984855308098,0.0001010560982854,0.558082575591327,3.888042106998,3.02252426488638,28.523060095548,0.942353466387901,0.0001077244819236,3.96768558587492,2.63211458386555,33.2911283333248,1.44512946670157e-05,"lineage4","dr_mutations_pyrazinamide","SER",0,"SAMN02403528","SRR1173296_SRR1167283_SRR1173328_SRR1165212","lineage4.8","za","South Africa","pnca_p.leu151ser","A","-","LEU","LA151","pnca_complex.pdb"
|
|
"L151S","L4","PZA","L","L151",151,"S",NA,"MDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",18.507,0.079,-2.523,3.86505,-2.175,-2.07,57,75,-0.04,5,5,10,0.0497512437810945,"loop",1.73333333333333,5.31,0.0010061808250682,8.75696202531646,8.7569577260426,8.75484033225151,18.8086142562631,18,0,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,-3,0,-3,0,10,0,4,8,0.0354260089686098,-0.651937984496124,0.140773534189497,-0.370843989769821,-0.541884816753927,0.6,-0.0329489291598023,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.244,0.083,"6:5","145/150","Q:F:Y:I:R:L:V:M:W",2.16984855308098,0.0001010560982854,0.558082575591327,3.888042106998,3.02252426488638,28.523060095548,0.942353466387901,0.0001077244819236,3.96768558587492,2.63211458386555,33.2911283333248,1.44512946670157e-05,"lineage4","dr_mutations_pyrazinamide","SER",0,"SAMN02586049","SRR1175058_SRR1184377_SRR1196475_SRR1172732","lineage4.8","za","South Africa","pnca_p.leu151ser","A","-","LEU","LA151","pnca_complex.pdb"
|
|
"L151S","L4","PZA","L","L151",151,"S",NA,"MDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",18.507,0.079,-2.523,3.86505,-2.175,-2.07,57,75,-0.04,5,5,10,0.0497512437810945,"loop",1.73333333333333,5.31,0.0010061808250682,8.75696202531646,8.7569577260426,8.75484033225151,18.8086142562631,18,0,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,-3,0,-3,0,10,0,4,8,0.0354260089686098,-0.651937984496124,0.140773534189497,-0.370843989769821,-0.541884816753927,0.6,-0.0329489291598023,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.244,0.083,"6:5","145/150","Q:F:Y:I:R:L:V:M:W",2.16984855308098,0.0001010560982854,0.558082575591327,3.888042106998,3.02252426488638,28.523060095548,0.942353466387901,0.0001077244819236,3.96768558587492,2.63211458386555,33.2911283333248,1.44512946670157e-05,"lineage4","dr_mutations_pyrazinamide","SER",0,"SAMN02403585","SRR1165638_SRR1167349_SRR1169185_SRR1172141","lineage4.8","za","South Africa","pnca_p.leu151ser","A","-","LEU","LA151","pnca_complex.pdb"
|
|
"L151S","L4","PZA","L","L151",151,"S",NA,"MDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",18.507,0.079,-2.523,3.86505,-2.175,-2.07,57,75,-0.04,5,5,10,0.0497512437810945,"loop",1.73333333333333,5.31,0.0010061808250682,8.75696202531646,8.7569577260426,8.75484033225151,18.8086142562631,18,0,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,-3,0,-3,0,10,0,4,8,0.0354260089686098,-0.651937984496124,0.140773534189497,-0.370843989769821,-0.541884816753927,0.6,-0.0329489291598023,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.244,0.083,"6:5","145/150","Q:F:Y:I:R:L:V:M:W",2.16984855308098,0.0001010560982854,0.558082575591327,3.888042106998,3.02252426488638,28.523060095548,0.942353466387901,0.0001077244819236,3.96768558587492,2.63211458386555,33.2911283333248,1.44512946670157e-05,"lineage4","dr_mutations_pyrazinamide","SER",0,"SAMN02403536","SRR1165641_SRR1169255_SRR1167381_SRR1169302","lineage4.8","za","South Africa","pnca_p.leu151ser","A","-","LEU","LA151","pnca_complex.pdb"
|
|
"L151S","L4","PZA","L","L151",151,"S",0,"MDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",18.507,0.079,-2.523,3.86505,-2.175,-2.07,57,75,-0.04,5,5,10,0.0497512437810945,"loop",1.73333333333333,5.31,0.0010061808250682,8.75696202531646,8.7569577260426,8.75484033225151,18.8086142562631,18,0,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,-3,0,-3,0,10,0,4,8,0.0354260089686098,-0.651937984496124,0.140773534189497,-0.370843989769821,-0.541884816753927,0.6,-0.0329489291598023,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.244,0.083,"6:5","145/150","Q:F:Y:I:R:L:V:M:W",2.16984855308098,0.0001010560982854,0.558082575591327,3.888042106998,3.02252426488638,28.523060095548,0.942353466387901,0.0001077244819236,3.96768558587492,2.63211458386555,33.2911283333248,1.44512946670157e-05,"lineage4","dr_mutations_pyrazinamide","SER",0,"SAMN02053763","SRR833082_SRR832994_SRR832986","lineage4.8","za","South Africa","pnca_p.leu151ser","A","-","LEU","LA151","pnca_complex.pdb"
|
|
"L151S","L4","PZA","L","L151",151,"S",NA,"MDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",18.507,0.079,-2.523,3.86505,-2.175,-2.07,57,75,-0.04,5,5,10,0.0497512437810945,"loop",1.73333333333333,5.31,0.0010061808250682,8.75696202531646,8.7569577260426,8.75484033225151,18.8086142562631,18,0,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,-3,0,-3,0,10,0,4,8,0.0354260089686098,-0.651937984496124,0.140773534189497,-0.370843989769821,-0.541884816753927,0.6,-0.0329489291598023,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.244,0.083,"6:5","145/150","Q:F:Y:I:R:L:V:M:W",2.16984855308098,0.0001010560982854,0.558082575591327,3.888042106998,3.02252426488638,28.523060095548,0.942353466387901,0.0001077244819236,3.96768558587492,2.63211458386555,33.2911283333248,1.44512946670157e-05,"lineage4","dr_mutations_pyrazinamide","SER",0,"SAMN02403592","SRR1167337_SRR1169125_SRR1165659_SRR1172311","lineage4.8","za","South Africa","pnca_p.leu151ser","A","-","LEU","LA151","pnca_complex.pdb"
|
|
"L151S","L4","PZA","L","L151",151,"S",NA,"MDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",18.507,0.079,-2.523,3.86505,-2.175,-2.07,57,75,-0.04,5,5,10,0.0497512437810945,"loop",1.73333333333333,5.31,0.0010061808250682,8.75696202531646,8.7569577260426,8.75484033225151,18.8086142562631,18,0,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,-3,0,-3,0,10,0,4,8,0.0354260089686098,-0.651937984496124,0.140773534189497,-0.370843989769821,-0.541884816753927,0.6,-0.0329489291598023,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.244,0.083,"6:5","145/150","Q:F:Y:I:R:L:V:M:W",2.16984855308098,0.0001010560982854,0.558082575591327,3.888042106998,3.02252426488638,28.523060095548,0.942353466387901,0.0001077244819236,3.96768558587492,2.63211458386555,33.2911283333248,1.44512946670157e-05,"lineage4","dr_mutations_pyrazinamide","SER",0,"SAMN02403584","SRR1165677_SRR1169226_SRR1167343_SRR1169323","lineage4.8","za","South Africa","pnca_p.leu151ser","A","-","LEU","LA151","pnca_complex.pdb"
|
|
"L151S","L4","PZA","L","L151",151,"S",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",18.507,0.079,-2.523,3.86505,-2.175,-2.07,57,75,-0.04,5,5,10,0.0497512437810945,"loop",1.73333333333333,5.31,0.0010061808250682,8.75696202531646,8.7569577260426,8.75484033225151,18.8086142562631,18,0,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,-3,0,-3,0,10,0,4,8,0.0354260089686098,-0.651937984496124,0.140773534189497,-0.370843989769821,-0.541884816753927,0.6,-0.0329489291598023,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.244,0.083,"6:5","145/150","Q:F:Y:I:R:L:V:M:W",2.16984855308098,0.0001010560982854,0.558082575591327,3.888042106998,3.02252426488638,28.523060095548,0.942353466387901,0.0001077244819236,3.96768558587492,2.63211458386555,33.2911283333248,1.44512946670157e-05,"lineage4","dr_mutations_pyrazinamide","SER",0,"SAMN02586082","SRR1180336_SRR1184041_SRR1181003_SRR1180364","lineage4.8","za","South Africa","pnca_p.leu151ser","A","-","LEU","LA151","pnca_complex.pdb"
|
|
"L151S","L4","PZA","L","L151",151,"S",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",18.507,0.079,-2.523,3.86505,-2.175,-2.07,57,75,-0.04,5,5,10,0.0497512437810945,"loop",1.73333333333333,5.31,0.0010061808250682,8.75696202531646,8.7569577260426,8.75484033225151,18.8086142562631,18,0,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,-3,0,-3,0,10,0,4,8,0.0354260089686098,-0.651937984496124,0.140773534189497,-0.370843989769821,-0.541884816753927,0.6,-0.0329489291598023,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.244,0.083,"6:5","145/150","Q:F:Y:I:R:L:V:M:W",2.16984855308098,0.0001010560982854,0.558082575591327,3.888042106998,3.02252426488638,28.523060095548,0.942353466387901,0.0001077244819236,3.96768558587492,2.63211458386555,33.2911283333248,1.44512946670157e-05,"lineage4","dr_mutations_pyrazinamide","SER",0,"SAMN02053754","SRR833028_SRR833188","lineage4.8","za","South Africa","pnca_p.leu151ser","A","-","LEU","LA151","pnca_complex.pdb"
|
|
"L151S","L4","PZA","L","L151",151,"S",1,"MDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",18.507,0.079,-2.523,3.86505,-2.175,-2.07,57,75,-0.04,5,5,10,0.0497512437810945,"loop",1.73333333333333,5.31,0.0010061808250682,8.75696202531646,8.7569577260426,8.75484033225151,18.8086142562631,18,0,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,-3,0,-3,0,10,0,4,8,0.0354260089686098,-0.651937984496124,0.140773534189497,-0.370843989769821,-0.541884816753927,0.6,-0.0329489291598023,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.244,0.083,"6:5","145/150","Q:F:Y:I:R:L:V:M:W",2.16984855308098,0.0001010560982854,0.558082575591327,3.888042106998,3.02252426488638,28.523060095548,0.942353466387901,0.0001077244819236,3.96768558587492,2.63211458386555,33.2911283333248,1.44512946670157e-05,"lineage4","dr_mutations_pyrazinamide","SER",0,"ERR2515612","ERR2515612","lineage4.8","za","South Africa","pnca_p.leu151ser","A","-","LEU","LA151","pnca_complex.pdb"
|
|
"L151S","L2","PZA","L","L151",151,"S",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",18.507,0.079,-2.523,3.86505,-2.175,-2.07,57,75,-0.04,5,5,10,0.0497512437810945,"loop",1.73333333333333,5.31,0.0010061808250682,8.75696202531646,8.7569577260426,8.75484033225151,18.8086142562631,18,0,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,-3,0,-3,0,10,0,4,8,0.0354260089686098,-0.651937984496124,0.140773534189497,-0.370843989769821,-0.541884816753927,0.6,-0.0329489291598023,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.244,0.083,"6:5","145/150","Q:F:Y:I:R:L:V:M:W",2.16984855308098,0.0001010560982854,0.558082575591327,3.888042106998,3.02252426488638,28.523060095548,0.942353466387901,0.0001077244819236,3.96768558587492,2.63211458386555,33.2911283333248,1.44512946670157e-05,"lineage2","dr_mutations_pyrazinamide","SER",0,"BGI_LN081,SRR671785","SRR671785","lineage2.2.1","cn","China","pnca_p.leu151ser","A","-","LEU","LA151","pnca_complex.pdb"
|
|
"L151S","L4","PZA","L","L151",151,"S",NA,"MDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",18.507,0.079,-2.523,3.86505,-2.175,-2.07,57,75,-0.04,5,5,10,0.0497512437810945,"loop",1.73333333333333,5.31,0.0010061808250682,8.75696202531646,8.7569577260426,8.75484033225151,18.8086142562631,18,0,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,-3,0,-3,0,10,0,4,8,0.0354260089686098,-0.651937984496124,0.140773534189497,-0.370843989769821,-0.541884816753927,0.6,-0.0329489291598023,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.244,0.083,"6:5","145/150","Q:F:Y:I:R:L:V:M:W",2.16984855308098,0.0001010560982854,0.558082575591327,3.888042106998,3.02252426488638,28.523060095548,0.942353466387901,0.0001077244819236,3.96768558587492,2.63211458386555,33.2911283333248,1.44512946670157e-05,"lineage4","dr_mutations_pyrazinamide","SER",0,"SAMN02403595","SRR1172096_SRR1169163_SRR1165718_SRR1165696","lineage4.8","za","South Africa","pnca_p.leu151ser","A","-","LEU","LA151","pnca_complex.pdb"
|
|
"L151V","L2","PZA","L","L151",151,"V",NA,"Other","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",18.507,-1.269,-1.74,1.09305,-1.108,-1.93,31,66,-0.04,5,5,10,0.0497512437810945,"loop",1.73333333333333,5.31,NA,NA,NA,NA,NA,18,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-5,0,-1,-4,-2,0,-2,2,-0.321428571428571,-0.449612403100775,0.0398112602801594,-0.188917306052856,-0.505235602094241,0.326315789473684,-0.0329489291598023,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.244,0.083,"6:5","145/150","Q:F:Y:I:R:L:V:M:W",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage2","other_mutations_pyrazinamide","VAL",0,"SRR5067646","SRR5067646","lineage2.2.1.1","vn","Vietnam","pnca_p.leu151val","A","-","LEU","LA151","pnca_complex.pdb"
|
|
"L151W","L2;L4","PZA","L","L151",151,"W",1,"XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",18.507,-0.714,-1.831,2.01402,-0.33,-2.26,20,63,-0.04,5,5,10,0.0497512437810945,"loop",1.73333333333333,5.31,7.18700589334483e-05,9.70142977291842,188179.926264453,Inf,0.763784339928386,-22,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-11,0,-3,-10,-10,0,-16,-2,-0.180851063829787,-0.47312661498708,0.0733549923877651,-0.0562659846547315,-0.591623036649215,0.210526315789474,-0.0329489291598023,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.244,0.083,"6:5","145/150","Q:F:Y:I:R:L:V:M:W",12.1451538387255,0.919026337424201,119.468044436174,0.101660271548297,5.01153666068148e-06,NA,0.986835744238421,0.170978870202674,0.767057556984365,0.124324963210678,Inf,0.382146811758261,"lineage2;lineage4","other_mutations_pyrazinamide","TRP",0,"XTB13-245","SRR1172073_SRR1163374_SRR1163172_SRR1169046","lineage4.3.3;lineage2.2.1","by","Belarus","pnca_p.leu151trp","A","-","LEU","LA151","pnca_complex.pdb"
|
|
"T153I","L4","PZA","T","T153",153,"I",NA,"Pre-MDR","OM","hydrophobic","hydrophobic","neutral","non-polar","polar","non-polar",15.544,-2.111,0.532,-0.698929,-1.456,-0.46,43,71,-0.188,6,6,12,0.0697674418604651,"strand",-1.13333333333333,5.38,NA,NA,NA,NA,NA,-20,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,-11,0,-5,-8,-2,0,-4,-2,-0.534701114488348,0.452380952380952,-0.134378412673998,-0.248252344416027,-0.120418848167539,0.452631578947368,-0.154859967051071,"Destabilising","Stabilising","Stabilising","Destabilising","Destabilising","effect",-0.411,-0.038,"7:5","144/150","V:C:A:S:T",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage4","other_mutations_pyrazinamide","ILE",0,"SRR5067274","SRR5067274","lineage4.2.2","vn","Vietnam","pnca_p.thr153ile","A","E","THR","TA153","pnca_complex.pdb"
|
|
"T153I","L4","PZA","T","T153",153,"I",NA,"MDR","OM","hydrophobic","hydrophobic","neutral","non-polar","polar","non-polar",15.544,-2.111,0.532,-0.698929,-1.456,-0.46,43,71,-0.188,6,6,12,0.0697674418604651,"strand",-1.13333333333333,5.38,NA,NA,NA,NA,NA,-20,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,-11,0,-5,-8,-2,0,-4,-2,-0.534701114488348,0.452380952380952,-0.134378412673998,-0.248252344416027,-0.120418848167539,0.452631578947368,-0.154859967051071,"Destabilising","Stabilising","Stabilising","Destabilising","Destabilising","effect",-0.411,-0.038,"7:5","144/150","V:C:A:S:T",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage4","other_mutations_pyrazinamide","ILE",0,"SAMN02381037","SRR1049723_SRR1062927_SRR1049724_SRR1140677","lineage4.6.1","ug","Uganda","pnca_p.thr153ile","A","E","THR","TA153","pnca_complex.pdb"
|
|
"T153P","L2","PZA","T","T153",153,"P",1,"Pre-XDR","OM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",15.544,-2.212,-0.926,3.60938,-4.405,-0.6,70,85,-0.188,6,6,12,0.0697674418604651,"strand",-1.13333333333333,5.38,7.18700589334483e-05,9.70142977291842,188179.926264634,Inf,0.763784339928386,0,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,-6,0,-6,-2,6,0,8,0,-0.560283687943262,-0.239276485788114,0.131461476263667,-0.751065643648764,-0.157068062827225,0.736842105263158,-0.154859967051071,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.411,-0.038,"7:5","144/150","V:C:A:S:T",12.1451538387264,0.919026337424234,119.468044436232,0.101660271548256,5.0115366606273e-06,NA,0.986835744238421,0.170978870202674,0.767057556984365,0.124324963210678,Inf,0.382146811758261,"lineage2","other_mutations_pyrazinamide","PRO",0,"SAMN10961392","SRR8651662","lineage2.2.1","cn","China:Wenzhou","pnca_p.thr153pro","A","E","THR","TA153","pnca_complex.pdb"
|
|
"R154G","L4","PZA","R","R154",154,"G",NA,"XDR","DM","hydrophilic","hydrophobic","basic","neutral","pos","non-polar",15.259,-2.707,-1.337,4.31639,-1.992,-1.71,73,85,1.542,1,1,60,0.218978102189781,"strand",-0.333333333333333,5.21,0.0011499209429351,34.1357293868922,34.1353729715529,34.1417078158954,51.1500808664409,66,28,0,4,24,0,0,0,0,2,0,0,2,0,0,0,0,0,0,-1,1,10,0,11,21,-0.685663627152989,-0.345478036175711,0.157212319437059,-0.339641943734015,-0.447643979057592,0.768421052631579,0.494230769230769,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.842,1.712,"2:1","144/150","T:W:E:F:Q:V:N:L:R:I:C:S:A:D:Y:H",3.530334177178,2.90603701922833e-06,0.754772029037902,4.6773516258652,9.53076902254824,217.507266299408,1.53320918696851,1.50118436279358e-09,8.82356596809844,7.82937374234326,309.275011521707,8.55671558873616e-13,"lineage4","dr_mutations_pyrazinamide","GLY",0,"SAMN02403532","SRR1165336_SRR1167260_SRR1173456_SRR1173876","lineage4.1.1.3","za","South Africa","pnca_p.arg154gly","A","E","ARG","RA154","pnca_complex.pdb"
|
|
"R154G","L4","PZA","R","R154",154,"G",NA,"XDR","DM","hydrophilic","hydrophobic","basic","neutral","pos","non-polar",15.259,-2.707,-1.337,4.31639,-1.992,-1.71,73,85,1.542,1,1,60,0.218978102189781,"strand",-0.333333333333333,5.21,0.0011499209429351,34.1357293868922,34.1353729715529,34.1417078158954,51.1500808664409,66,28,0,4,24,0,0,0,0,2,0,0,2,0,0,0,0,0,0,-1,1,10,0,11,21,-0.685663627152989,-0.345478036175711,0.157212319437059,-0.339641943734015,-0.447643979057592,0.768421052631579,0.494230769230769,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.842,1.712,"2:1","144/150","T:W:E:F:Q:V:N:L:R:I:C:S:A:D:Y:H",3.530334177178,2.90603701922833e-06,0.754772029037902,4.6773516258652,9.53076902254824,217.507266299408,1.53320918696851,1.50118436279358e-09,8.82356596809844,7.82937374234326,309.275011521707,8.55671558873616e-13,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR2515826","ERR2515826","lineage4.1.1.3","za","South Africa","pnca_p.arg154gly","A","E","ARG","RA154","pnca_complex.pdb"
|
|
"R154G","L4","PZA","R","R154",154,"G",NA,"MDR","DM","hydrophilic","hydrophobic","basic","neutral","pos","non-polar",15.259,-2.707,-1.337,4.31639,-1.992,-1.71,73,85,1.542,1,1,60,0.218978102189781,"strand",-0.333333333333333,5.21,0.0011499209429351,34.1357293868922,34.1353729715529,34.1417078158954,51.1500808664409,66,28,0,4,24,0,0,0,0,2,0,0,2,0,0,0,0,0,0,-1,1,10,0,11,21,-0.685663627152989,-0.345478036175711,0.157212319437059,-0.339641943734015,-0.447643979057592,0.768421052631579,0.494230769230769,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.842,1.712,"2:1","144/150","T:W:E:F:Q:V:N:L:R:I:C:S:A:D:Y:H",3.530334177178,2.90603701922833e-06,0.754772029037902,4.6773516258652,9.53076902254824,217.507266299408,1.53320918696851,1.50118436279358e-09,8.82356596809844,7.82937374234326,309.275011521707,8.55671558873616e-13,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR550959","ERR550959","lineage4.1.1.3","sz","Swaziland","pnca_p.arg154gly","A","E","ARG","RA154","pnca_complex.pdb"
|
|
"R154G","L4","PZA","R","R154",154,"G",NA,"Pre-XDR","DM","hydrophilic","hydrophobic","basic","neutral","pos","non-polar",15.259,-2.707,-1.337,4.31639,-1.992,-1.71,73,85,1.542,1,1,60,0.218978102189781,"strand",-0.333333333333333,5.21,0.0011499209429351,34.1357293868922,34.1353729715529,34.1417078158954,51.1500808664409,66,28,0,4,24,0,0,0,0,2,0,0,2,0,0,0,0,0,0,-1,1,10,0,11,21,-0.685663627152989,-0.345478036175711,0.157212319437059,-0.339641943734015,-0.447643979057592,0.768421052631579,0.494230769230769,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.842,1.712,"2:1","144/150","T:W:E:F:Q:V:N:L:R:I:C:S:A:D:Y:H",3.530334177178,2.90603701922833e-06,0.754772029037902,4.6773516258652,9.53076902254824,217.507266299408,1.53320918696851,1.50118436279358e-09,8.82356596809844,7.82937374234326,309.275011521707,8.55671558873616e-13,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR2515990","ERR2515990","lineage4.1.1.3","za","South Africa","pnca_p.arg154gly","A","E","ARG","RA154","pnca_complex.pdb"
|
|
"R154G","L4","PZA","R","R154",154,"G",0,"MDR","DM","hydrophilic","hydrophobic","basic","neutral","pos","non-polar",15.259,-2.707,-1.337,4.31639,-1.992,-1.71,73,85,1.542,1,1,60,0.218978102189781,"strand",-0.333333333333333,5.21,0.0011499209429351,34.1357293868922,34.1353729715529,34.1417078158954,51.1500808664409,66,28,0,4,24,0,0,0,0,2,0,0,2,0,0,0,0,0,0,-1,1,10,0,11,21,-0.685663627152989,-0.345478036175711,0.157212319437059,-0.339641943734015,-0.447643979057592,0.768421052631579,0.494230769230769,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.842,1.712,"2:1","144/150","T:W:E:F:Q:V:N:L:R:I:C:S:A:D:Y:H",3.530334177178,2.90603701922833e-06,0.754772029037902,4.6773516258652,9.53076902254824,217.507266299408,1.53320918696851,1.50118436279358e-09,8.82356596809844,7.82937374234326,309.275011521707,8.55671558873616e-13,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR2515346","ERR2515346","lineage4.1.1.3","za","South Africa","pnca_p.arg154gly","A","E","ARG","RA154","pnca_complex.pdb"
|
|
"R154G","L4","PZA","R","R154",154,"G",1,"MDR","DM","hydrophilic","hydrophobic","basic","neutral","pos","non-polar",15.259,-2.707,-1.337,4.31639,-1.992,-1.71,73,85,1.542,1,1,60,0.218978102189781,"strand",-0.333333333333333,5.21,0.0011499209429351,34.1357293868922,34.1353729715529,34.1417078158954,51.1500808664409,66,28,0,4,24,0,0,0,0,2,0,0,2,0,0,0,0,0,0,-1,1,10,0,11,21,-0.685663627152989,-0.345478036175711,0.157212319437059,-0.339641943734015,-0.447643979057592,0.768421052631579,0.494230769230769,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.842,1.712,"2:1","144/150","T:W:E:F:Q:V:N:L:R:I:C:S:A:D:Y:H",3.530334177178,2.90603701922833e-06,0.754772029037902,4.6773516258652,9.53076902254824,217.507266299408,1.53320918696851,1.50118436279358e-09,8.82356596809844,7.82937374234326,309.275011521707,8.55671558873616e-13,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR550864","ERR550864","lineage4.1.1.3","sz","Swaziland","pnca_p.arg154gly","A","E","ARG","RA154","pnca_complex.pdb"
|
|
"R154G","L4","PZA","R","R154",154,"G",NA,"Pre-XDR","DM","hydrophilic","hydrophobic","basic","neutral","pos","non-polar",15.259,-2.707,-1.337,4.31639,-1.992,-1.71,73,85,1.542,1,1,60,0.218978102189781,"strand",-0.333333333333333,5.21,0.0011499209429351,34.1357293868922,34.1353729715529,34.1417078158954,51.1500808664409,66,28,0,4,24,0,0,0,0,2,0,0,2,0,0,0,0,0,0,-1,1,10,0,11,21,-0.685663627152989,-0.345478036175711,0.157212319437059,-0.339641943734015,-0.447643979057592,0.768421052631579,0.494230769230769,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.842,1.712,"2:1","144/150","T:W:E:F:Q:V:N:L:R:I:C:S:A:D:Y:H",3.530334177178,2.90603701922833e-06,0.754772029037902,4.6773516258652,9.53076902254824,217.507266299408,1.53320918696851,1.50118436279358e-09,8.82356596809844,7.82937374234326,309.275011521707,8.55671558873616e-13,"lineage4","dr_mutations_pyrazinamide","GLY",0,"SAMN02350483","SRR1019158_SRR1140951","lineage4.1.1.3","za","South Africa","pnca_p.arg154gly","A","E","ARG","RA154","pnca_complex.pdb"
|
|
"R154G","L4","PZA","R","R154",154,"G",1,"MDR","DM","hydrophilic","hydrophobic","basic","neutral","pos","non-polar",15.259,-2.707,-1.337,4.31639,-1.992,-1.71,73,85,1.542,1,1,60,0.218978102189781,"strand",-0.333333333333333,5.21,0.0011499209429351,34.1357293868922,34.1353729715529,34.1417078158954,51.1500808664409,66,28,0,4,24,0,0,0,0,2,0,0,2,0,0,0,0,0,0,-1,1,10,0,11,21,-0.685663627152989,-0.345478036175711,0.157212319437059,-0.339641943734015,-0.447643979057592,0.768421052631579,0.494230769230769,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.842,1.712,"2:1","144/150","T:W:E:F:Q:V:N:L:R:I:C:S:A:D:Y:H",3.530334177178,2.90603701922833e-06,0.754772029037902,4.6773516258652,9.53076902254824,217.507266299408,1.53320918696851,1.50118436279358e-09,8.82356596809844,7.82937374234326,309.275011521707,8.55671558873616e-13,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR552994","ERR552994","lineage4.1.1.3","sz","Swaziland","pnca_p.arg154gly","A","E","ARG","RA154","pnca_complex.pdb"
|
|
"R154G","L4","PZA","R","R154",154,"G",1,"MDR","DM","hydrophilic","hydrophobic","basic","neutral","pos","non-polar",15.259,-2.707,-1.337,4.31639,-1.992,-1.71,73,85,1.542,1,1,60,0.218978102189781,"strand",-0.333333333333333,5.21,0.0011499209429351,34.1357293868922,34.1353729715529,34.1417078158954,51.1500808664409,66,28,0,4,24,0,0,0,0,2,0,0,2,0,0,0,0,0,0,-1,1,10,0,11,21,-0.685663627152989,-0.345478036175711,0.157212319437059,-0.339641943734015,-0.447643979057592,0.768421052631579,0.494230769230769,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.842,1.712,"2:1","144/150","T:W:E:F:Q:V:N:L:R:I:C:S:A:D:Y:H",3.530334177178,2.90603701922833e-06,0.754772029037902,4.6773516258652,9.53076902254824,217.507266299408,1.53320918696851,1.50118436279358e-09,8.82356596809844,7.82937374234326,309.275011521707,8.55671558873616e-13,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR552288","ERR552288","lineage4.1.1.3","sz","Swaziland","pnca_p.arg154gly","A","E","ARG","RA154","pnca_complex.pdb"
|
|
"R154G","L4","PZA","R","R154",154,"G",NA,"MDR","DM","hydrophilic","hydrophobic","basic","neutral","pos","non-polar",15.259,-2.707,-1.337,4.31639,-1.992,-1.71,73,85,1.542,1,1,60,0.218978102189781,"strand",-0.333333333333333,5.21,0.0011499209429351,34.1357293868922,34.1353729715529,34.1417078158954,51.1500808664409,66,28,0,4,24,0,0,0,0,2,0,0,2,0,0,0,0,0,0,-1,1,10,0,11,21,-0.685663627152989,-0.345478036175711,0.157212319437059,-0.339641943734015,-0.447643979057592,0.768421052631579,0.494230769230769,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.842,1.712,"2:1","144/150","T:W:E:F:Q:V:N:L:R:I:C:S:A:D:Y:H",3.530334177178,2.90603701922833e-06,0.754772029037902,4.6773516258652,9.53076902254824,217.507266299408,1.53320918696851,1.50118436279358e-09,8.82356596809844,7.82937374234326,309.275011521707,8.55671558873616e-13,"lineage4","dr_mutations_pyrazinamide","GLY",0,"SAMN02403542","SRR1172247_SRR1167338_SRR1169190_SRR1165691","lineage4.1.1.3","za","South Africa","pnca_p.arg154gly","A","E","ARG","RA154","pnca_complex.pdb"
|
|
"R154G","L2","PZA","R","R154",154,"G",NA,"Pre-XDR","DM","hydrophilic","hydrophobic","basic","neutral","pos","non-polar",15.259,-2.707,-1.337,4.31639,-1.992,-1.71,73,85,1.542,1,1,60,0.218978102189781,"strand",-0.333333333333333,5.21,0.0011499209429351,34.1357293868922,34.1353729715529,34.1417078158954,51.1500808664409,66,28,0,4,24,0,0,0,0,2,0,0,2,0,0,0,0,0,0,-1,1,10,0,11,21,-0.685663627152989,-0.345478036175711,0.157212319437059,-0.339641943734015,-0.447643979057592,0.768421052631579,0.494230769230769,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.842,1.712,"2:1","144/150","T:W:E:F:Q:V:N:L:R:I:C:S:A:D:Y:H",3.530334177178,2.90603701922833e-06,0.754772029037902,4.6773516258652,9.53076902254824,217.507266299408,1.53320918696851,1.50118436279358e-09,8.82356596809844,7.82937374234326,309.275011521707,8.55671558873616e-13,"lineage2","dr_mutations_pyrazinamide","GLY",0,"BGI_FJ07036,SRR671755","SRR671755","lineage2.2.1","cn","China","pnca_p.arg154gly","A","E","ARG","RA154","pnca_complex.pdb"
|
|
"R154G","L4","PZA","R","R154",154,"G",NA,"MDR","DM","hydrophilic","hydrophobic","basic","neutral","pos","non-polar",15.259,-2.707,-1.337,4.31639,-1.992,-1.71,73,85,1.542,1,1,60,0.218978102189781,"strand",-0.333333333333333,5.21,0.0011499209429351,34.1357293868922,34.1353729715529,34.1417078158954,51.1500808664409,66,28,0,4,24,0,0,0,0,2,0,0,2,0,0,0,0,0,0,-1,1,10,0,11,21,-0.685663627152989,-0.345478036175711,0.157212319437059,-0.339641943734015,-0.447643979057592,0.768421052631579,0.494230769230769,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.842,1.712,"2:1","144/150","T:W:E:F:Q:V:N:L:R:I:C:S:A:D:Y:H",3.530334177178,2.90603701922833e-06,0.754772029037902,4.6773516258652,9.53076902254824,217.507266299408,1.53320918696851,1.50118436279358e-09,8.82356596809844,7.82937374234326,309.275011521707,8.55671558873616e-13,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR551393","ERR551393","lineage4.1.1.3","sz","Swaziland","pnca_p.arg154gly","A","E","ARG","RA154","pnca_complex.pdb"
|
|
"R154G","L4","PZA","R","R154",154,"G",1,"XDR","DM","hydrophilic","hydrophobic","basic","neutral","pos","non-polar",15.259,-2.707,-1.337,4.31639,-1.992,-1.71,73,85,1.542,1,1,60,0.218978102189781,"strand",-0.333333333333333,5.21,0.0011499209429351,34.1357293868922,34.1353729715529,34.1417078158954,51.1500808664409,66,28,0,4,24,0,0,0,0,2,0,0,2,0,0,0,0,0,0,-1,1,10,0,11,21,-0.685663627152989,-0.345478036175711,0.157212319437059,-0.339641943734015,-0.447643979057592,0.768421052631579,0.494230769230769,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.842,1.712,"2:1","144/150","T:W:E:F:Q:V:N:L:R:I:C:S:A:D:Y:H",3.530334177178,2.90603701922833e-06,0.754772029037902,4.6773516258652,9.53076902254824,217.507266299408,1.53320918696851,1.50118436279358e-09,8.82356596809844,7.82937374234326,309.275011521707,8.55671558873616e-13,"lineage4","dr_mutations_pyrazinamide","GLY",0,"SAMN02350424","SRR1062837_SRR1011465","lineage4.1.1.3","za","South Africa","pnca_p.arg154gly","A","E","ARG","RA154","pnca_complex.pdb"
|
|
"R154G","L4","PZA","R","R154",154,"G",1,"MDR","DM","hydrophilic","hydrophobic","basic","neutral","pos","non-polar",15.259,-2.707,-1.337,4.31639,-1.992,-1.71,73,85,1.542,1,1,60,0.218978102189781,"strand",-0.333333333333333,5.21,0.0011499209429351,34.1357293868922,34.1353729715529,34.1417078158954,51.1500808664409,66,28,0,4,24,0,0,0,0,2,0,0,2,0,0,0,0,0,0,-1,1,10,0,11,21,-0.685663627152989,-0.345478036175711,0.157212319437059,-0.339641943734015,-0.447643979057592,0.768421052631579,0.494230769230769,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.842,1.712,"2:1","144/150","T:W:E:F:Q:V:N:L:R:I:C:S:A:D:Y:H",3.530334177178,2.90603701922833e-06,0.754772029037902,4.6773516258652,9.53076902254824,217.507266299408,1.53320918696851,1.50118436279358e-09,8.82356596809844,7.82937374234326,309.275011521707,8.55671558873616e-13,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR553354","ERR553354","lineage4.1.1.3","sz","Swaziland","pnca_p.arg154gly","A","E","ARG","RA154","pnca_complex.pdb"
|
|
"R154G","L4","PZA","R","R154",154,"G",NA,"MDR","DM","hydrophilic","hydrophobic","basic","neutral","pos","non-polar",15.259,-2.707,-1.337,4.31639,-1.992,-1.71,73,85,1.542,1,1,60,0.218978102189781,"strand",-0.333333333333333,5.21,0.0011499209429351,34.1357293868922,34.1353729715529,34.1417078158954,51.1500808664409,66,28,0,4,24,0,0,0,0,2,0,0,2,0,0,0,0,0,0,-1,1,10,0,11,21,-0.685663627152989,-0.345478036175711,0.157212319437059,-0.339641943734015,-0.447643979057592,0.768421052631579,0.494230769230769,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.842,1.712,"2:1","144/150","T:W:E:F:Q:V:N:L:R:I:C:S:A:D:Y:H",3.530334177178,2.90603701922833e-06,0.754772029037902,4.6773516258652,9.53076902254824,217.507266299408,1.53320918696851,1.50118436279358e-09,8.82356596809844,7.82937374234326,309.275011521707,8.55671558873616e-13,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR552361","ERR552361","lineage4.1.1.3","sz","Swaziland","pnca_p.arg154gly","A","E","ARG","RA154","pnca_complex.pdb"
|
|
"R154G","L4","PZA","R","R154",154,"G",NA,"Pre-XDR","DM","hydrophilic","hydrophobic","basic","neutral","pos","non-polar",15.259,-2.707,-1.337,4.31639,-1.992,-1.71,73,85,1.542,1,1,60,0.218978102189781,"strand",-0.333333333333333,5.21,0.0011499209429351,34.1357293868922,34.1353729715529,34.1417078158954,51.1500808664409,66,28,0,4,24,0,0,0,0,2,0,0,2,0,0,0,0,0,0,-1,1,10,0,11,21,-0.685663627152989,-0.345478036175711,0.157212319437059,-0.339641943734015,-0.447643979057592,0.768421052631579,0.494230769230769,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.842,1.712,"2:1","144/150","T:W:E:F:Q:V:N:L:R:I:C:S:A:D:Y:H",3.530334177178,2.90603701922833e-06,0.754772029037902,4.6773516258652,9.53076902254824,217.507266299408,1.53320918696851,1.50118436279358e-09,8.82356596809844,7.82937374234326,309.275011521707,8.55671558873616e-13,"lineage4","dr_mutations_pyrazinamide","GLY",0,"SAMN02403523","SRR1165209_SRR1167307_SRR1173624_SRR1173407","lineage4.1.1.3","za","South Africa","pnca_p.arg154gly","A","E","ARG","RA154","pnca_complex.pdb"
|
|
"R154G","L4","PZA","R","R154",154,"G",NA,"Pre-XDR","DM","hydrophilic","hydrophobic","basic","neutral","pos","non-polar",15.259,-2.707,-1.337,4.31639,-1.992,-1.71,73,85,1.542,1,1,60,0.218978102189781,"strand",-0.333333333333333,5.21,0.0011499209429351,34.1357293868922,34.1353729715529,34.1417078158954,51.1500808664409,66,28,0,4,24,0,0,0,0,2,0,0,2,0,0,0,0,0,0,-1,1,10,0,11,21,-0.685663627152989,-0.345478036175711,0.157212319437059,-0.339641943734015,-0.447643979057592,0.768421052631579,0.494230769230769,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.842,1.712,"2:1","144/150","T:W:E:F:Q:V:N:L:R:I:C:S:A:D:Y:H",3.530334177178,2.90603701922833e-06,0.754772029037902,4.6773516258652,9.53076902254824,217.507266299408,1.53320918696851,1.50118436279358e-09,8.82356596809844,7.82937374234326,309.275011521707,8.55671558873616e-13,"lineage4","dr_mutations_pyrazinamide","GLY",0,"SAMN02350428","SRR1011469_SRR1062841","lineage4.1.1.3","za","South Africa","pnca_p.arg154gly","A","E","ARG","RA154","pnca_complex.pdb"
|
|
"R154G","L2","PZA","R","R154",154,"G",NA,"MDR","DM","hydrophilic","hydrophobic","basic","neutral","pos","non-polar",15.259,-2.707,-1.337,4.31639,-1.992,-1.71,73,85,1.542,1,1,60,0.218978102189781,"strand",-0.333333333333333,5.21,0.0011499209429351,34.1357293868922,34.1353729715529,34.1417078158954,51.1500808664409,66,28,0,4,24,0,0,0,0,2,0,0,2,0,0,0,0,0,0,-1,1,10,0,11,21,-0.685663627152989,-0.345478036175711,0.157212319437059,-0.339641943734015,-0.447643979057592,0.768421052631579,0.494230769230769,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.842,1.712,"2:1","144/150","T:W:E:F:Q:V:N:L:R:I:C:S:A:D:Y:H",3.530334177178,2.90603701922833e-06,0.754772029037902,4.6773516258652,9.53076902254824,217.507266299408,1.53320918696851,1.50118436279358e-09,8.82356596809844,7.82937374234326,309.275011521707,8.55671558873616e-13,"lineage2","dr_mutations_pyrazinamide","GLY",0,"SRR5067704","SRR5067704","lineage2.2.1","vn","Vietnam","pnca_p.arg154gly","A","E","ARG","RA154","pnca_complex.pdb"
|
|
"R154G","L4","PZA","R","R154",154,"G",NA,"XDR","DM","hydrophilic","hydrophobic","basic","neutral","pos","non-polar",15.259,-2.707,-1.337,4.31639,-1.992,-1.71,73,85,1.542,1,1,60,0.218978102189781,"strand",-0.333333333333333,5.21,0.0011499209429351,34.1357293868922,34.1353729715529,34.1417078158954,51.1500808664409,66,28,0,4,24,0,0,0,0,2,0,0,2,0,0,0,0,0,0,-1,1,10,0,11,21,-0.685663627152989,-0.345478036175711,0.157212319437059,-0.339641943734015,-0.447643979057592,0.768421052631579,0.494230769230769,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.842,1.712,"2:1","144/150","T:W:E:F:Q:V:N:L:R:I:C:S:A:D:Y:H",3.530334177178,2.90603701922833e-06,0.754772029037902,4.6773516258652,9.53076902254824,217.507266299408,1.53320918696851,1.50118436279358e-09,8.82356596809844,7.82937374234326,309.275011521707,8.55671558873616e-13,"lineage4","dr_mutations_pyrazinamide","GLY",0,"SAMN02586027","SRR1172836_SRR1173032","lineage4.1.1.3","za","South Africa","pnca_p.arg154gly","A","E","ARG","RA154","pnca_complex.pdb"
|
|
"R154G","L4","PZA","R","R154",154,"G",1,"XDR","DM","hydrophilic","hydrophobic","basic","neutral","pos","non-polar",15.259,-2.707,-1.337,4.31639,-1.992,-1.71,73,85,1.542,1,1,60,0.218978102189781,"strand",-0.333333333333333,5.21,0.0011499209429351,34.1357293868922,34.1353729715529,34.1417078158954,51.1500808664409,66,28,0,4,24,0,0,0,0,2,0,0,2,0,0,0,0,0,0,-1,1,10,0,11,21,-0.685663627152989,-0.345478036175711,0.157212319437059,-0.339641943734015,-0.447643979057592,0.768421052631579,0.494230769230769,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.842,1.712,"2:1","144/150","T:W:E:F:Q:V:N:L:R:I:C:S:A:D:Y:H",3.530334177178,2.90603701922833e-06,0.754772029037902,4.6773516258652,9.53076902254824,217.507266299408,1.53320918696851,1.50118436279358e-09,8.82356596809844,7.82937374234326,309.275011521707,8.55671558873616e-13,"lineage4","dr_mutations_pyrazinamide","GLY",0,"SAMN01925645","SRR924217_SRR847790","lineage4.1.1.3","za","South Africa","pnca_p.arg154gly","A","E","ARG","RA154","pnca_complex.pdb"
|
|
"R154G","L4","PZA","R","R154",154,"G",NA,"MDR","DM","hydrophilic","hydrophobic","basic","neutral","pos","non-polar",15.259,-2.707,-1.337,4.31639,-1.992,-1.71,73,85,1.542,1,1,60,0.218978102189781,"strand",-0.333333333333333,5.21,0.0011499209429351,34.1357293868922,34.1353729715529,34.1417078158954,51.1500808664409,66,28,0,4,24,0,0,0,0,2,0,0,2,0,0,0,0,0,0,-1,1,10,0,11,21,-0.685663627152989,-0.345478036175711,0.157212319437059,-0.339641943734015,-0.447643979057592,0.768421052631579,0.494230769230769,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.842,1.712,"2:1","144/150","T:W:E:F:Q:V:N:L:R:I:C:S:A:D:Y:H",3.530334177178,2.90603701922833e-06,0.754772029037902,4.6773516258652,9.53076902254824,217.507266299408,1.53320918696851,1.50118436279358e-09,8.82356596809844,7.82937374234326,309.275011521707,8.55671558873616e-13,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR553343","ERR553343","lineage4.1.1.3","sz","Swaziland","pnca_p.arg154gly","A","E","ARG","RA154","pnca_complex.pdb"
|
|
"R154G","L4","PZA","R","R154",154,"G",0,"Pre-XDR","DM","hydrophilic","hydrophobic","basic","neutral","pos","non-polar",15.259,-2.707,-1.337,4.31639,-1.992,-1.71,73,85,1.542,1,1,60,0.218978102189781,"strand",-0.333333333333333,5.21,0.0011499209429351,34.1357293868922,34.1353729715529,34.1417078158954,51.1500808664409,66,28,0,4,24,0,0,0,0,2,0,0,2,0,0,0,0,0,0,-1,1,10,0,11,21,-0.685663627152989,-0.345478036175711,0.157212319437059,-0.339641943734015,-0.447643979057592,0.768421052631579,0.494230769230769,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.842,1.712,"2:1","144/150","T:W:E:F:Q:V:N:L:R:I:C:S:A:D:Y:H",3.530334177178,2.90603701922833e-06,0.754772029037902,4.6773516258652,9.53076902254824,217.507266299408,1.53320918696851,1.50118436279358e-09,8.82356596809844,7.82937374234326,309.275011521707,8.55671558873616e-13,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR2515262","ERR2515262","lineage4.1.1.3","za","South Africa","pnca_p.arg154gly","A","E","ARG","RA154","pnca_complex.pdb"
|
|
"R154G","L4","PZA","R","R154",154,"G",NA,"MDR","DM","hydrophilic","hydrophobic","basic","neutral","pos","non-polar",15.259,-2.707,-1.337,4.31639,-1.992,-1.71,73,85,1.542,1,1,60,0.218978102189781,"strand",-0.333333333333333,5.21,0.0011499209429351,34.1357293868922,34.1353729715529,34.1417078158954,51.1500808664409,66,28,0,4,24,0,0,0,0,2,0,0,2,0,0,0,0,0,0,-1,1,10,0,11,21,-0.685663627152989,-0.345478036175711,0.157212319437059,-0.339641943734015,-0.447643979057592,0.768421052631579,0.494230769230769,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.842,1.712,"2:1","144/150","T:W:E:F:Q:V:N:L:R:I:C:S:A:D:Y:H",3.530334177178,2.90603701922833e-06,0.754772029037902,4.6773516258652,9.53076902254824,217.507266299408,1.53320918696851,1.50118436279358e-09,8.82356596809844,7.82937374234326,309.275011521707,8.55671558873616e-13,"lineage4","dr_mutations_pyrazinamide","GLY",0,"SAMN02403525","SRR1167271_SRR1173213_SRR1173587_SRR1165306","lineage4.1.1.3","za","South Africa","pnca_p.arg154gly","A","E","ARG","RA154","pnca_complex.pdb"
|
|
"R154G","L4","PZA","R","R154",154,"G",NA,"MDR","DM","hydrophilic","hydrophobic","basic","neutral","pos","non-polar",15.259,-2.707,-1.337,4.31639,-1.992,-1.71,73,85,1.542,1,1,60,0.218978102189781,"strand",-0.333333333333333,5.21,0.0011499209429351,34.1357293868922,34.1353729715529,34.1417078158954,51.1500808664409,66,28,0,4,24,0,0,0,0,2,0,0,2,0,0,0,0,0,0,-1,1,10,0,11,21,-0.685663627152989,-0.345478036175711,0.157212319437059,-0.339641943734015,-0.447643979057592,0.768421052631579,0.494230769230769,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.842,1.712,"2:1","144/150","T:W:E:F:Q:V:N:L:R:I:C:S:A:D:Y:H",3.530334177178,2.90603701922833e-06,0.754772029037902,4.6773516258652,9.53076902254824,217.507266299408,1.53320918696851,1.50118436279358e-09,8.82356596809844,7.82937374234326,309.275011521707,8.55671558873616e-13,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR552075","ERR552075","lineage4.1.1.3","sz","Swaziland","pnca_p.arg154gly","A","E","ARG","RA154","pnca_complex.pdb"
|
|
"R154G","L4","PZA","R","R154",154,"G",NA,"MDR","DM","hydrophilic","hydrophobic","basic","neutral","pos","non-polar",15.259,-2.707,-1.337,4.31639,-1.992,-1.71,73,85,1.542,1,1,60,0.218978102189781,"strand",-0.333333333333333,5.21,0.0011499209429351,34.1357293868922,34.1353729715529,34.1417078158954,51.1500808664409,66,28,0,4,24,0,0,0,0,2,0,0,2,0,0,0,0,0,0,-1,1,10,0,11,21,-0.685663627152989,-0.345478036175711,0.157212319437059,-0.339641943734015,-0.447643979057592,0.768421052631579,0.494230769230769,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.842,1.712,"2:1","144/150","T:W:E:F:Q:V:N:L:R:I:C:S:A:D:Y:H",3.530334177178,2.90603701922833e-06,0.754772029037902,4.6773516258652,9.53076902254824,217.507266299408,1.53320918696851,1.50118436279358e-09,8.82356596809844,7.82937374234326,309.275011521707,8.55671558873616e-13,"lineage4","dr_mutations_pyrazinamide","GLY",0,"SAMN02403541","SRR1172330_SRR1165675_SRR1169189_SRR1167368","lineage4.1.1.3","za","South Africa","pnca_p.arg154gly","A","E","ARG","RA154","pnca_complex.pdb"
|
|
"R154G","L4","PZA","R","R154",154,"G",NA,"XDR","DM","hydrophilic","hydrophobic","basic","neutral","pos","non-polar",15.259,-2.707,-1.337,4.31639,-1.992,-1.71,73,85,1.542,1,1,60,0.218978102189781,"strand",-0.333333333333333,5.21,0.0011499209429351,34.1357293868922,34.1353729715529,34.1417078158954,51.1500808664409,66,28,0,4,24,0,0,0,0,2,0,0,2,0,0,0,0,0,0,-1,1,10,0,11,21,-0.685663627152989,-0.345478036175711,0.157212319437059,-0.339641943734015,-0.447643979057592,0.768421052631579,0.494230769230769,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.842,1.712,"2:1","144/150","T:W:E:F:Q:V:N:L:R:I:C:S:A:D:Y:H",3.530334177178,2.90603701922833e-06,0.754772029037902,4.6773516258652,9.53076902254824,217.507266299408,1.53320918696851,1.50118436279358e-09,8.82356596809844,7.82937374234326,309.275011521707,8.55671558873616e-13,"lineage4","dr_mutations_pyrazinamide","GLY",0,"SAMN02403576","SRR1165713_SRR1165683_SRR1172306_SRR1169167","lineage4.1.1.3","za","South Africa","pnca_p.arg154gly","A","E","ARG","RA154","pnca_complex.pdb"
|
|
"R154G","L4","PZA","R","R154",154,"G",1,"MDR","DM","hydrophilic","hydrophobic","basic","neutral","pos","non-polar",15.259,-2.707,-1.337,4.31639,-1.992,-1.71,73,85,1.542,1,1,60,0.218978102189781,"strand",-0.333333333333333,5.21,0.0011499209429351,34.1357293868922,34.1353729715529,34.1417078158954,51.1500808664409,66,28,0,4,24,0,0,0,0,2,0,0,2,0,0,0,0,0,0,-1,1,10,0,11,21,-0.685663627152989,-0.345478036175711,0.157212319437059,-0.339641943734015,-0.447643979057592,0.768421052631579,0.494230769230769,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.842,1.712,"2:1","144/150","T:W:E:F:Q:V:N:L:R:I:C:S:A:D:Y:H",3.530334177178,2.90603701922833e-06,0.754772029037902,4.6773516258652,9.53076902254824,217.507266299408,1.53320918696851,1.50118436279358e-09,8.82356596809844,7.82937374234326,309.275011521707,8.55671558873616e-13,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR550636","ERR550636","lineage4.6.1;lineage4.3;lineage4.1.1.3","sz","Swaziland","pnca_p.arg154gly","A","E","ARG","RA154","pnca_complex.pdb"
|
|
"R154G","L4","PZA","R","R154",154,"G",1,"MDR","DM","hydrophilic","hydrophobic","basic","neutral","pos","non-polar",15.259,-2.707,-1.337,4.31639,-1.992,-1.71,73,85,1.542,1,1,60,0.218978102189781,"strand",-0.333333333333333,5.21,0.0011499209429351,34.1357293868922,34.1353729715529,34.1417078158954,51.1500808664409,66,28,0,4,24,0,0,0,0,2,0,0,2,0,0,0,0,0,0,-1,1,10,0,11,21,-0.685663627152989,-0.345478036175711,0.157212319437059,-0.339641943734015,-0.447643979057592,0.768421052631579,0.494230769230769,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.842,1.712,"2:1","144/150","T:W:E:F:Q:V:N:L:R:I:C:S:A:D:Y:H",3.530334177178,2.90603701922833e-06,0.754772029037902,4.6773516258652,9.53076902254824,217.507266299408,1.53320918696851,1.50118436279358e-09,8.82356596809844,7.82937374234326,309.275011521707,8.55671558873616e-13,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR551938","ERR551938","lineage4.1.1.3","sz","Swaziland","pnca_p.arg154gly","A","E","ARG","RA154","pnca_complex.pdb"
|
|
"R154G","L4","PZA","R","R154",154,"G",NA,"XDR","DM","hydrophilic","hydrophobic","basic","neutral","pos","non-polar",15.259,-2.707,-1.337,4.31639,-1.992,-1.71,73,85,1.542,1,1,60,0.218978102189781,"strand",-0.333333333333333,5.21,0.0011499209429351,34.1357293868922,34.1353729715529,34.1417078158954,51.1500808664409,66,28,0,4,24,0,0,0,0,2,0,0,2,0,0,0,0,0,0,-1,1,10,0,11,21,-0.685663627152989,-0.345478036175711,0.157212319437059,-0.339641943734015,-0.447643979057592,0.768421052631579,0.494230769230769,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.842,1.712,"2:1","144/150","T:W:E:F:Q:V:N:L:R:I:C:S:A:D:Y:H",3.530334177178,2.90603701922833e-06,0.754772029037902,4.6773516258652,9.53076902254824,217.507266299408,1.53320918696851,1.50118436279358e-09,8.82356596809844,7.82937374234326,309.275011521707,8.55671558873616e-13,"lineage4","dr_mutations_pyrazinamide","GLY",0,"2368","ERR2433008","lineage4.1.1.3","br","Momazbique","pnca_p.arg154gly","A","E","ARG","RA154","pnca_complex.pdb"
|
|
"R154G","L4","PZA","R","R154",154,"G",NA,"XDR","DM","hydrophilic","hydrophobic","basic","neutral","pos","non-polar",15.259,-2.707,-1.337,4.31639,-1.992,-1.71,73,85,1.542,1,1,60,0.218978102189781,"strand",-0.333333333333333,5.21,0.0011499209429351,34.1357293868922,34.1353729715529,34.1417078158954,51.1500808664409,66,28,0,4,24,0,0,0,0,2,0,0,2,0,0,0,0,0,0,-1,1,10,0,11,21,-0.685663627152989,-0.345478036175711,0.157212319437059,-0.339641943734015,-0.447643979057592,0.768421052631579,0.494230769230769,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.842,1.712,"2:1","144/150","T:W:E:F:Q:V:N:L:R:I:C:S:A:D:Y:H",3.530334177178,2.90603701922833e-06,0.754772029037902,4.6773516258652,9.53076902254824,217.507266299408,1.53320918696851,1.50118436279358e-09,8.82356596809844,7.82937374234326,309.275011521707,8.55671558873616e-13,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR2515794","ERR2515794","lineage4.1.1.3","za","South Africa","pnca_p.arg154gly","A","E","ARG","RA154","pnca_complex.pdb"
|
|
"R154G","L4","PZA","R","R154",154,"G",NA,"Pre-XDR","DM","hydrophilic","hydrophobic","basic","neutral","pos","non-polar",15.259,-2.707,-1.337,4.31639,-1.992,-1.71,73,85,1.542,1,1,60,0.218978102189781,"strand",-0.333333333333333,5.21,0.0011499209429351,34.1357293868922,34.1353729715529,34.1417078158954,51.1500808664409,66,28,0,4,24,0,0,0,0,2,0,0,2,0,0,0,0,0,0,-1,1,10,0,11,21,-0.685663627152989,-0.345478036175711,0.157212319437059,-0.339641943734015,-0.447643979057592,0.768421052631579,0.494230769230769,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.842,1.712,"2:1","144/150","T:W:E:F:Q:V:N:L:R:I:C:S:A:D:Y:H",3.530334177178,2.90603701922833e-06,0.754772029037902,4.6773516258652,9.53076902254824,217.507266299408,1.53320918696851,1.50118436279358e-09,8.82356596809844,7.82937374234326,309.275011521707,8.55671558873616e-13,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR552720","ERR552720","lineage4.1.1.3","sz","Swaziland","pnca_p.arg154gly","A","E","ARG","RA154","pnca_complex.pdb"
|
|
"R154G","L4","PZA","R","R154",154,"G",NA,"MDR","DM","hydrophilic","hydrophobic","basic","neutral","pos","non-polar",15.259,-2.707,-1.337,4.31639,-1.992,-1.71,73,85,1.542,1,1,60,0.218978102189781,"strand",-0.333333333333333,5.21,0.0011499209429351,34.1357293868922,34.1353729715529,34.1417078158954,51.1500808664409,66,28,0,4,24,0,0,0,0,2,0,0,2,0,0,0,0,0,0,-1,1,10,0,11,21,-0.685663627152989,-0.345478036175711,0.157212319437059,-0.339641943734015,-0.447643979057592,0.768421052631579,0.494230769230769,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.842,1.712,"2:1","144/150","T:W:E:F:Q:V:N:L:R:I:C:S:A:D:Y:H",3.530334177178,2.90603701922833e-06,0.754772029037902,4.6773516258652,9.53076902254824,217.507266299408,1.53320918696851,1.50118436279358e-09,8.82356596809844,7.82937374234326,309.275011521707,8.55671558873616e-13,"lineage4","dr_mutations_pyrazinamide","GLY",0,"SAMN02053765","SRR833056_SRR833068","lineage4.1.1.3","za","South Africa","pnca_p.arg154gly","A","E","ARG","RA154","pnca_complex.pdb"
|
|
"R154G","L4","PZA","R","R154",154,"G",NA,"MDR","DM","hydrophilic","hydrophobic","basic","neutral","pos","non-polar",15.259,-2.707,-1.337,4.31639,-1.992,-1.71,73,85,1.542,1,1,60,0.218978102189781,"strand",-0.333333333333333,5.21,0.0011499209429351,34.1357293868922,34.1353729715529,34.1417078158954,51.1500808664409,66,28,0,4,24,0,0,0,0,2,0,0,2,0,0,0,0,0,0,-1,1,10,0,11,21,-0.685663627152989,-0.345478036175711,0.157212319437059,-0.339641943734015,-0.447643979057592,0.768421052631579,0.494230769230769,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.842,1.712,"2:1","144/150","T:W:E:F:Q:V:N:L:R:I:C:S:A:D:Y:H",3.530334177178,2.90603701922833e-06,0.754772029037902,4.6773516258652,9.53076902254824,217.507266299408,1.53320918696851,1.50118436279358e-09,8.82356596809844,7.82937374234326,309.275011521707,8.55671558873616e-13,"lineage4","dr_mutations_pyrazinamide","GLY",0,"SAMN02403522","SRR1165274_SRR1173737_SRR1173736_SRR1167266","lineage4.1.1.3","za","South Africa","pnca_p.arg154gly","A","E","ARG","RA154","pnca_complex.pdb"
|
|
"R154G","L4","PZA","R","R154",154,"G",NA,"MDR","DM","hydrophilic","hydrophobic","basic","neutral","pos","non-polar",15.259,-2.707,-1.337,4.31639,-1.992,-1.71,73,85,1.542,1,1,60,0.218978102189781,"strand",-0.333333333333333,5.21,0.0011499209429351,34.1357293868922,34.1353729715529,34.1417078158954,51.1500808664409,66,28,0,4,24,0,0,0,0,2,0,0,2,0,0,0,0,0,0,-1,1,10,0,11,21,-0.685663627152989,-0.345478036175711,0.157212319437059,-0.339641943734015,-0.447643979057592,0.768421052631579,0.494230769230769,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.842,1.712,"2:1","144/150","T:W:E:F:Q:V:N:L:R:I:C:S:A:D:Y:H",3.530334177178,2.90603701922833e-06,0.754772029037902,4.6773516258652,9.53076902254824,217.507266299408,1.53320918696851,1.50118436279358e-09,8.82356596809844,7.82937374234326,309.275011521707,8.55671558873616e-13,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR553105","ERR553105","lineage4.1.1.3","sz","Swaziland","pnca_p.arg154gly","A","E","ARG","RA154","pnca_complex.pdb"
|
|
"R154G","L4","PZA","R","R154",154,"G",1,"MDR","DM","hydrophilic","hydrophobic","basic","neutral","pos","non-polar",15.259,-2.707,-1.337,4.31639,-1.992,-1.71,73,85,1.542,1,1,60,0.218978102189781,"strand",-0.333333333333333,5.21,0.0011499209429351,34.1357293868922,34.1353729715529,34.1417078158954,51.1500808664409,66,28,0,4,24,0,0,0,0,2,0,0,2,0,0,0,0,0,0,-1,1,10,0,11,21,-0.685663627152989,-0.345478036175711,0.157212319437059,-0.339641943734015,-0.447643979057592,0.768421052631579,0.494230769230769,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.842,1.712,"2:1","144/150","T:W:E:F:Q:V:N:L:R:I:C:S:A:D:Y:H",3.530334177178,2.90603701922833e-06,0.754772029037902,4.6773516258652,9.53076902254824,217.507266299408,1.53320918696851,1.50118436279358e-09,8.82356596809844,7.82937374234326,309.275011521707,8.55671558873616e-13,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR552073","ERR552073","lineage4.1.1.3","sz","Swaziland","pnca_p.arg154gly","A","E","ARG","RA154","pnca_complex.pdb"
|
|
"R154G","L2","PZA","R","R154",154,"G",1,"MDR","DM","hydrophilic","hydrophobic","basic","neutral","pos","non-polar",15.259,-2.707,-1.337,4.31639,-1.992,-1.71,73,85,1.542,1,1,60,0.218978102189781,"strand",-0.333333333333333,5.21,0.0011499209429351,34.1357293868922,34.1353729715529,34.1417078158954,51.1500808664409,66,28,0,4,24,0,0,0,0,2,0,0,2,0,0,0,0,0,0,-1,1,10,0,11,21,-0.685663627152989,-0.345478036175711,0.157212319437059,-0.339641943734015,-0.447643979057592,0.768421052631579,0.494230769230769,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.842,1.712,"2:1","144/150","T:W:E:F:Q:V:N:L:R:I:C:S:A:D:Y:H",3.530334177178,2.90603701922833e-06,0.754772029037902,4.6773516258652,9.53076902254824,217.507266299408,1.53320918696851,1.50118436279358e-09,8.82356596809844,7.82937374234326,309.275011521707,8.55671558873616e-13,"lineage2","dr_mutations_pyrazinamide","GLY",0,"ERR230005,2382Q-sc-2012-10-11T13:40:23Z-1494324","ERR230005","lineage2.2.1","ru","Russia,Samara","pnca_p.arg154gly","A","E","ARG","RA154","pnca_complex.pdb"
|
|
"R154G","L4","PZA","R","R154",154,"G",NA,"MDR","DM","hydrophilic","hydrophobic","basic","neutral","pos","non-polar",15.259,-2.707,-1.337,4.31639,-1.992,-1.71,73,85,1.542,1,1,60,0.218978102189781,"strand",-0.333333333333333,5.21,0.0011499209429351,34.1357293868922,34.1353729715529,34.1417078158954,51.1500808664409,66,28,0,4,24,0,0,0,0,2,0,0,2,0,0,0,0,0,0,-1,1,10,0,11,21,-0.685663627152989,-0.345478036175711,0.157212319437059,-0.339641943734015,-0.447643979057592,0.768421052631579,0.494230769230769,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.842,1.712,"2:1","144/150","T:W:E:F:Q:V:N:L:R:I:C:S:A:D:Y:H",3.530334177178,2.90603701922833e-06,0.754772029037902,4.6773516258652,9.53076902254824,217.507266299408,1.53320918696851,1.50118436279358e-09,8.82356596809844,7.82937374234326,309.275011521707,8.55671558873616e-13,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR552751","ERR552751","lineage4.1.1.3","sz","Swaziland","pnca_p.arg154gly","A","E","ARG","RA154","pnca_complex.pdb"
|
|
"R154G","L4","PZA","R","R154",154,"G",NA,"MDR","DM","hydrophilic","hydrophobic","basic","neutral","pos","non-polar",15.259,-2.707,-1.337,4.31639,-1.992,-1.71,73,85,1.542,1,1,60,0.218978102189781,"strand",-0.333333333333333,5.21,0.0011499209429351,34.1357293868922,34.1353729715529,34.1417078158954,51.1500808664409,66,28,0,4,24,0,0,0,0,2,0,0,2,0,0,0,0,0,0,-1,1,10,0,11,21,-0.685663627152989,-0.345478036175711,0.157212319437059,-0.339641943734015,-0.447643979057592,0.768421052631579,0.494230769230769,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.842,1.712,"2:1","144/150","T:W:E:F:Q:V:N:L:R:I:C:S:A:D:Y:H",3.530334177178,2.90603701922833e-06,0.754772029037902,4.6773516258652,9.53076902254824,217.507266299408,1.53320918696851,1.50118436279358e-09,8.82356596809844,7.82937374234326,309.275011521707,8.55671558873616e-13,"lineage4","dr_mutations_pyrazinamide","GLY",0,"SAMN02403577","SRR1165673_SRR1165714_SRR1169241_SRR1169272","lineage4.1.1.3","za","South Africa","pnca_p.arg154gly","A","E","ARG","RA154","pnca_complex.pdb"
|
|
"R154G","L4","PZA","R","R154",154,"G",NA,"XDR","DM","hydrophilic","hydrophobic","basic","neutral","pos","non-polar",15.259,-2.707,-1.337,4.31639,-1.992,-1.71,73,85,1.542,1,1,60,0.218978102189781,"strand",-0.333333333333333,5.21,0.0011499209429351,34.1357293868922,34.1353729715529,34.1417078158954,51.1500808664409,66,28,0,4,24,0,0,0,0,2,0,0,2,0,0,0,0,0,0,-1,1,10,0,11,21,-0.685663627152989,-0.345478036175711,0.157212319437059,-0.339641943734015,-0.447643979057592,0.768421052631579,0.494230769230769,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.842,1.712,"2:1","144/150","T:W:E:F:Q:V:N:L:R:I:C:S:A:D:Y:H",3.530334177178,2.90603701922833e-06,0.754772029037902,4.6773516258652,9.53076902254824,217.507266299408,1.53320918696851,1.50118436279358e-09,8.82356596809844,7.82937374234326,309.275011521707,8.55671558873616e-13,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR2515479","ERR2515479","lineage4.1.1.3","za","South Africa","pnca_p.arg154gly","A","E","ARG","RA154","pnca_complex.pdb"
|
|
"R154G","L4","PZA","R","R154",154,"G",1,"MDR","DM","hydrophilic","hydrophobic","basic","neutral","pos","non-polar",15.259,-2.707,-1.337,4.31639,-1.992,-1.71,73,85,1.542,1,1,60,0.218978102189781,"strand",-0.333333333333333,5.21,0.0011499209429351,34.1357293868922,34.1353729715529,34.1417078158954,51.1500808664409,66,28,0,4,24,0,0,0,0,2,0,0,2,0,0,0,0,0,0,-1,1,10,0,11,21,-0.685663627152989,-0.345478036175711,0.157212319437059,-0.339641943734015,-0.447643979057592,0.768421052631579,0.494230769230769,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.842,1.712,"2:1","144/150","T:W:E:F:Q:V:N:L:R:I:C:S:A:D:Y:H",3.530334177178,2.90603701922833e-06,0.754772029037902,4.6773516258652,9.53076902254824,217.507266299408,1.53320918696851,1.50118436279358e-09,8.82356596809844,7.82937374234326,309.275011521707,8.55671558873616e-13,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR552151","ERR552151","lineage4.1.1.3","sz","Swaziland","pnca_p.arg154gly","A","E","ARG","RA154","pnca_complex.pdb"
|
|
"R154G","L4","PZA","R","R154",154,"G",NA,"MDR","DM","hydrophilic","hydrophobic","basic","neutral","pos","non-polar",15.259,-2.707,-1.337,4.31639,-1.992,-1.71,73,85,1.542,1,1,60,0.218978102189781,"strand",-0.333333333333333,5.21,0.0011499209429351,34.1357293868922,34.1353729715529,34.1417078158954,51.1500808664409,66,28,0,4,24,0,0,0,0,2,0,0,2,0,0,0,0,0,0,-1,1,10,0,11,21,-0.685663627152989,-0.345478036175711,0.157212319437059,-0.339641943734015,-0.447643979057592,0.768421052631579,0.494230769230769,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.842,1.712,"2:1","144/150","T:W:E:F:Q:V:N:L:R:I:C:S:A:D:Y:H",3.530334177178,2.90603701922833e-06,0.754772029037902,4.6773516258652,9.53076902254824,217.507266299408,1.53320918696851,1.50118436279358e-09,8.82356596809844,7.82937374234326,309.275011521707,8.55671558873616e-13,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR551246","ERR551246","lineage4.1.1.3","sz","Swaziland","pnca_p.arg154gly","A","E","ARG","RA154","pnca_complex.pdb"
|
|
"R154G","L4","PZA","R","R154",154,"G",NA,"MDR","DM","hydrophilic","hydrophobic","basic","neutral","pos","non-polar",15.259,-2.707,-1.337,4.31639,-1.992,-1.71,73,85,1.542,1,1,60,0.218978102189781,"strand",-0.333333333333333,5.21,0.0011499209429351,34.1357293868922,34.1353729715529,34.1417078158954,51.1500808664409,66,28,0,4,24,0,0,0,0,2,0,0,2,0,0,0,0,0,0,-1,1,10,0,11,21,-0.685663627152989,-0.345478036175711,0.157212319437059,-0.339641943734015,-0.447643979057592,0.768421052631579,0.494230769230769,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.842,1.712,"2:1","144/150","T:W:E:F:Q:V:N:L:R:I:C:S:A:D:Y:H",3.530334177178,2.90603701922833e-06,0.754772029037902,4.6773516258652,9.53076902254824,217.507266299408,1.53320918696851,1.50118436279358e-09,8.82356596809844,7.82937374234326,309.275011521707,8.55671558873616e-13,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR553186","ERR553186","lineage4.1.1.3","sz","Swaziland","pnca_p.arg154gly","A","E","ARG","RA154","pnca_complex.pdb"
|
|
"R154G","L4","PZA","R","R154",154,"G",NA,"MDR","DM","hydrophilic","hydrophobic","basic","neutral","pos","non-polar",15.259,-2.707,-1.337,4.31639,-1.992,-1.71,73,85,1.542,1,1,60,0.218978102189781,"strand",-0.333333333333333,5.21,0.0011499209429351,34.1357293868922,34.1353729715529,34.1417078158954,51.1500808664409,66,28,0,4,24,0,0,0,0,2,0,0,2,0,0,0,0,0,0,-1,1,10,0,11,21,-0.685663627152989,-0.345478036175711,0.157212319437059,-0.339641943734015,-0.447643979057592,0.768421052631579,0.494230769230769,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.842,1.712,"2:1","144/150","T:W:E:F:Q:V:N:L:R:I:C:S:A:D:Y:H",3.530334177178,2.90603701922833e-06,0.754772029037902,4.6773516258652,9.53076902254824,217.507266299408,1.53320918696851,1.50118436279358e-09,8.82356596809844,7.82937374234326,309.275011521707,8.55671558873616e-13,"lineage4","dr_mutations_pyrazinamide","GLY",0,"SAMN02350472","SRR1019151_SRR1140965","lineage4.1.1.3","za","South Africa","pnca_p.arg154gly","A","E","ARG","RA154","pnca_complex.pdb"
|
|
"R154G","L4","PZA","R","R154",154,"G",NA,"MDR","DM","hydrophilic","hydrophobic","basic","neutral","pos","non-polar",15.259,-2.707,-1.337,4.31639,-1.992,-1.71,73,85,1.542,1,1,60,0.218978102189781,"strand",-0.333333333333333,5.21,0.0011499209429351,34.1357293868922,34.1353729715529,34.1417078158954,51.1500808664409,66,28,0,4,24,0,0,0,0,2,0,0,2,0,0,0,0,0,0,-1,1,10,0,11,21,-0.685663627152989,-0.345478036175711,0.157212319437059,-0.339641943734015,-0.447643979057592,0.768421052631579,0.494230769230769,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.842,1.712,"2:1","144/150","T:W:E:F:Q:V:N:L:R:I:C:S:A:D:Y:H",3.530334177178,2.90603701922833e-06,0.754772029037902,4.6773516258652,9.53076902254824,217.507266299408,1.53320918696851,1.50118436279358e-09,8.82356596809844,7.82937374234326,309.275011521707,8.55671558873616e-13,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR2516454","ERR2516454","lineage4.1.2.1","nl","Netherlands","pnca_p.arg154gly","A","E","ARG","RA154","pnca_complex.pdb"
|
|
"R154G","L4","PZA","R","R154",154,"G",1,"MDR","DM","hydrophilic","hydrophobic","basic","neutral","pos","non-polar",15.259,-2.707,-1.337,4.31639,-1.992,-1.71,73,85,1.542,1,1,60,0.218978102189781,"strand",-0.333333333333333,5.21,0.0011499209429351,34.1357293868922,34.1353729715529,34.1417078158954,51.1500808664409,66,28,0,4,24,0,0,0,0,2,0,0,2,0,0,0,0,0,0,-1,1,10,0,11,21,-0.685663627152989,-0.345478036175711,0.157212319437059,-0.339641943734015,-0.447643979057592,0.768421052631579,0.494230769230769,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.842,1.712,"2:1","144/150","T:W:E:F:Q:V:N:L:R:I:C:S:A:D:Y:H",3.530334177178,2.90603701922833e-06,0.754772029037902,4.6773516258652,9.53076902254824,217.507266299408,1.53320918696851,1.50118436279358e-09,8.82356596809844,7.82937374234326,309.275011521707,8.55671558873616e-13,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR550734","ERR550734","lineage4.1.1.3","sz","Swaziland","pnca_p.arg154gly","A","E","ARG","RA154","pnca_complex.pdb"
|
|
"R154G","L4","PZA","R","R154",154,"G",NA,"MDR","DM","hydrophilic","hydrophobic","basic","neutral","pos","non-polar",15.259,-2.707,-1.337,4.31639,-1.992,-1.71,73,85,1.542,1,1,60,0.218978102189781,"strand",-0.333333333333333,5.21,0.0011499209429351,34.1357293868922,34.1353729715529,34.1417078158954,51.1500808664409,66,28,0,4,24,0,0,0,0,2,0,0,2,0,0,0,0,0,0,-1,1,10,0,11,21,-0.685663627152989,-0.345478036175711,0.157212319437059,-0.339641943734015,-0.447643979057592,0.768421052631579,0.494230769230769,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.842,1.712,"2:1","144/150","T:W:E:F:Q:V:N:L:R:I:C:S:A:D:Y:H",3.530334177178,2.90603701922833e-06,0.754772029037902,4.6773516258652,9.53076902254824,217.507266299408,1.53320918696851,1.50118436279358e-09,8.82356596809844,7.82937374234326,309.275011521707,8.55671558873616e-13,"lineage4","dr_mutations_pyrazinamide","GLY",0,"SAMN02403533","SRR1169289_SRR1169256_SRR1165663_SRR1167333","lineage4.1.1.3","za","South Africa","pnca_p.arg154gly","A","E","ARG","RA154","pnca_complex.pdb"
|
|
"R154G","L4","PZA","R","R154",154,"G",1,"MDR","DM","hydrophilic","hydrophobic","basic","neutral","pos","non-polar",15.259,-2.707,-1.337,4.31639,-1.992,-1.71,73,85,1.542,1,1,60,0.218978102189781,"strand",-0.333333333333333,5.21,0.0011499209429351,34.1357293868922,34.1353729715529,34.1417078158954,51.1500808664409,66,28,0,4,24,0,0,0,0,2,0,0,2,0,0,0,0,0,0,-1,1,10,0,11,21,-0.685663627152989,-0.345478036175711,0.157212319437059,-0.339641943734015,-0.447643979057592,0.768421052631579,0.494230769230769,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.842,1.712,"2:1","144/150","T:W:E:F:Q:V:N:L:R:I:C:S:A:D:Y:H",3.530334177178,2.90603701922833e-06,0.754772029037902,4.6773516258652,9.53076902254824,217.507266299408,1.53320918696851,1.50118436279358e-09,8.82356596809844,7.82937374234326,309.275011521707,8.55671558873616e-13,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR553328","ERR553328","lineage4.1.1.3","sz","Swaziland","pnca_p.arg154gly","A","E","ARG","RA154","pnca_complex.pdb"
|
|
"R154G","L4","PZA","R","R154",154,"G",NA,"XDR","DM","hydrophilic","hydrophobic","basic","neutral","pos","non-polar",15.259,-2.707,-1.337,4.31639,-1.992,-1.71,73,85,1.542,1,1,60,0.218978102189781,"strand",-0.333333333333333,5.21,0.0011499209429351,34.1357293868922,34.1353729715529,34.1417078158954,51.1500808664409,66,28,0,4,24,0,0,0,0,2,0,0,2,0,0,0,0,0,0,-1,1,10,0,11,21,-0.685663627152989,-0.345478036175711,0.157212319437059,-0.339641943734015,-0.447643979057592,0.768421052631579,0.494230769230769,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.842,1.712,"2:1","144/150","T:W:E:F:Q:V:N:L:R:I:C:S:A:D:Y:H",3.530334177178,2.90603701922833e-06,0.754772029037902,4.6773516258652,9.53076902254824,217.507266299408,1.53320918696851,1.50118436279358e-09,8.82356596809844,7.82937374234326,309.275011521707,8.55671558873616e-13,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR2515597","ERR2515597","lineage4.1.1.3","za","South Africa","pnca_p.arg154gly","A","E","ARG","RA154","pnca_complex.pdb"
|
|
"R154G","L4","PZA","R","R154",154,"G",NA,"Pre-XDR","DM","hydrophilic","hydrophobic","basic","neutral","pos","non-polar",15.259,-2.707,-1.337,4.31639,-1.992,-1.71,73,85,1.542,1,1,60,0.218978102189781,"strand",-0.333333333333333,5.21,0.0011499209429351,34.1357293868922,34.1353729715529,34.1417078158954,51.1500808664409,66,28,0,4,24,0,0,0,0,2,0,0,2,0,0,0,0,0,0,-1,1,10,0,11,21,-0.685663627152989,-0.345478036175711,0.157212319437059,-0.339641943734015,-0.447643979057592,0.768421052631579,0.494230769230769,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.842,1.712,"2:1","144/150","T:W:E:F:Q:V:N:L:R:I:C:S:A:D:Y:H",3.530334177178,2.90603701922833e-06,0.754772029037902,4.6773516258652,9.53076902254824,217.507266299408,1.53320918696851,1.50118436279358e-09,8.82356596809844,7.82937374234326,309.275011521707,8.55671558873616e-13,"lineage4","dr_mutations_pyrazinamide","GLY",0,"SAMN02585970","SRR1181322_SRR1180232_SRR1183001_SRR1181086","lineage4.1.1.3","za","South Africa","pnca_p.arg154gly","A","E","ARG","RA154","pnca_complex.pdb"
|
|
"R154G","L4","PZA","R","R154",154,"G",NA,"XDR","DM","hydrophilic","hydrophobic","basic","neutral","pos","non-polar",15.259,-2.707,-1.337,4.31639,-1.992,-1.71,73,85,1.542,1,1,60,0.218978102189781,"strand",-0.333333333333333,5.21,0.0011499209429351,34.1357293868922,34.1353729715529,34.1417078158954,51.1500808664409,66,28,0,4,24,0,0,0,0,2,0,0,2,0,0,0,0,0,0,-1,1,10,0,11,21,-0.685663627152989,-0.345478036175711,0.157212319437059,-0.339641943734015,-0.447643979057592,0.768421052631579,0.494230769230769,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.842,1.712,"2:1","144/150","T:W:E:F:Q:V:N:L:R:I:C:S:A:D:Y:H",3.530334177178,2.90603701922833e-06,0.754772029037902,4.6773516258652,9.53076902254824,217.507266299408,1.53320918696851,1.50118436279358e-09,8.82356596809844,7.82937374234326,309.275011521707,8.55671558873616e-13,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR552296","ERR552296","lineage4.1.1.3","sz","Swaziland","pnca_p.arg154gly","A","E","ARG","RA154","pnca_complex.pdb"
|
|
"R154G","L4","PZA","R","R154",154,"G",NA,"XDR","DM","hydrophilic","hydrophobic","basic","neutral","pos","non-polar",15.259,-2.707,-1.337,4.31639,-1.992,-1.71,73,85,1.542,1,1,60,0.218978102189781,"strand",-0.333333333333333,5.21,0.0011499209429351,34.1357293868922,34.1353729715529,34.1417078158954,51.1500808664409,66,28,0,4,24,0,0,0,0,2,0,0,2,0,0,0,0,0,0,-1,1,10,0,11,21,-0.685663627152989,-0.345478036175711,0.157212319437059,-0.339641943734015,-0.447643979057592,0.768421052631579,0.494230769230769,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.842,1.712,"2:1","144/150","T:W:E:F:Q:V:N:L:R:I:C:S:A:D:Y:H",3.530334177178,2.90603701922833e-06,0.754772029037902,4.6773516258652,9.53076902254824,217.507266299408,1.53320918696851,1.50118436279358e-09,8.82356596809844,7.82937374234326,309.275011521707,8.55671558873616e-13,"lineage4","dr_mutations_pyrazinamide","GLY",0,"SAMN02403545","SRR1165695_SRR1169203_SRR1169301_SRR1165669","lineage4.1.1.3","za","South Africa","pnca_p.arg154gly","A","E","ARG","RA154","pnca_complex.pdb"
|
|
"R154G","L4","PZA","R","R154",154,"G",1,"MDR","DM","hydrophilic","hydrophobic","basic","neutral","pos","non-polar",15.259,-2.707,-1.337,4.31639,-1.992,-1.71,73,85,1.542,1,1,60,0.218978102189781,"strand",-0.333333333333333,5.21,0.0011499209429351,34.1357293868922,34.1353729715529,34.1417078158954,51.1500808664409,66,28,0,4,24,0,0,0,0,2,0,0,2,0,0,0,0,0,0,-1,1,10,0,11,21,-0.685663627152989,-0.345478036175711,0.157212319437059,-0.339641943734015,-0.447643979057592,0.768421052631579,0.494230769230769,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.842,1.712,"2:1","144/150","T:W:E:F:Q:V:N:L:R:I:C:S:A:D:Y:H",3.530334177178,2.90603701922833e-06,0.754772029037902,4.6773516258652,9.53076902254824,217.507266299408,1.53320918696851,1.50118436279358e-09,8.82356596809844,7.82937374234326,309.275011521707,8.55671558873616e-13,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR553204","ERR553204","lineage4.1.1.3","sz","Swaziland","pnca_p.arg154gly","A","E","ARG","RA154","pnca_complex.pdb"
|
|
"R154G","L4","PZA","R","R154",154,"G",NA,"MDR","DM","hydrophilic","hydrophobic","basic","neutral","pos","non-polar",15.259,-2.707,-1.337,4.31639,-1.992,-1.71,73,85,1.542,1,1,60,0.218978102189781,"strand",-0.333333333333333,5.21,0.0011499209429351,34.1357293868922,34.1353729715529,34.1417078158954,51.1500808664409,66,28,0,4,24,0,0,0,0,2,0,0,2,0,0,0,0,0,0,-1,1,10,0,11,21,-0.685663627152989,-0.345478036175711,0.157212319437059,-0.339641943734015,-0.447643979057592,0.768421052631579,0.494230769230769,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.842,1.712,"2:1","144/150","T:W:E:F:Q:V:N:L:R:I:C:S:A:D:Y:H",3.530334177178,2.90603701922833e-06,0.754772029037902,4.6773516258652,9.53076902254824,217.507266299408,1.53320918696851,1.50118436279358e-09,8.82356596809844,7.82937374234326,309.275011521707,8.55671558873616e-13,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR553264","ERR553264","lineage4.1.1.3","sz","Swaziland","pnca_p.arg154gly","A","E","ARG","RA154","pnca_complex.pdb"
|
|
"R154G","L4","PZA","R","R154",154,"G",NA,"MDR","DM","hydrophilic","hydrophobic","basic","neutral","pos","non-polar",15.259,-2.707,-1.337,4.31639,-1.992,-1.71,73,85,1.542,1,1,60,0.218978102189781,"strand",-0.333333333333333,5.21,0.0011499209429351,34.1357293868922,34.1353729715529,34.1417078158954,51.1500808664409,66,28,0,4,24,0,0,0,0,2,0,0,2,0,0,0,0,0,0,-1,1,10,0,11,21,-0.685663627152989,-0.345478036175711,0.157212319437059,-0.339641943734015,-0.447643979057592,0.768421052631579,0.494230769230769,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.842,1.712,"2:1","144/150","T:W:E:F:Q:V:N:L:R:I:C:S:A:D:Y:H",3.530334177178,2.90603701922833e-06,0.754772029037902,4.6773516258652,9.53076902254824,217.507266299408,1.53320918696851,1.50118436279358e-09,8.82356596809844,7.82937374234326,309.275011521707,8.55671558873616e-13,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR2515386","ERR2515386","lineage4.1.1.3","za","South Africa","pnca_p.arg154gly","A","E","ARG","RA154","pnca_complex.pdb"
|
|
"R154G","L4","PZA","R","R154",154,"G",NA,"MDR","DM","hydrophilic","hydrophobic","basic","neutral","pos","non-polar",15.259,-2.707,-1.337,4.31639,-1.992,-1.71,73,85,1.542,1,1,60,0.218978102189781,"strand",-0.333333333333333,5.21,0.0011499209429351,34.1357293868922,34.1353729715529,34.1417078158954,51.1500808664409,66,28,0,4,24,0,0,0,0,2,0,0,2,0,0,0,0,0,0,-1,1,10,0,11,21,-0.685663627152989,-0.345478036175711,0.157212319437059,-0.339641943734015,-0.447643979057592,0.768421052631579,0.494230769230769,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.842,1.712,"2:1","144/150","T:W:E:F:Q:V:N:L:R:I:C:S:A:D:Y:H",3.530334177178,2.90603701922833e-06,0.754772029037902,4.6773516258652,9.53076902254824,217.507266299408,1.53320918696851,1.50118436279358e-09,8.82356596809844,7.82937374234326,309.275011521707,8.55671558873616e-13,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR552917","ERR552917","lineage4.1.1.3","sz","Swaziland","pnca_p.arg154gly","A","E","ARG","RA154","pnca_complex.pdb"
|
|
"R154G","L4","PZA","R","R154",154,"G",NA,"MDR","DM","hydrophilic","hydrophobic","basic","neutral","pos","non-polar",15.259,-2.707,-1.337,4.31639,-1.992,-1.71,73,85,1.542,1,1,60,0.218978102189781,"strand",-0.333333333333333,5.21,0.0011499209429351,34.1357293868922,34.1353729715529,34.1417078158954,51.1500808664409,66,28,0,4,24,0,0,0,0,2,0,0,2,0,0,0,0,0,0,-1,1,10,0,11,21,-0.685663627152989,-0.345478036175711,0.157212319437059,-0.339641943734015,-0.447643979057592,0.768421052631579,0.494230769230769,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.842,1.712,"2:1","144/150","T:W:E:F:Q:V:N:L:R:I:C:S:A:D:Y:H",3.530334177178,2.90603701922833e-06,0.754772029037902,4.6773516258652,9.53076902254824,217.507266299408,1.53320918696851,1.50118436279358e-09,8.82356596809844,7.82937374234326,309.275011521707,8.55671558873616e-13,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR553028","ERR553028","lineage4.1.1.3","sz","Swaziland","pnca_p.arg154gly","A","E","ARG","RA154","pnca_complex.pdb"
|
|
"R154G","L4","PZA","R","R154",154,"G",NA,"XDR","DM","hydrophilic","hydrophobic","basic","neutral","pos","non-polar",15.259,-2.707,-1.337,4.31639,-1.992,-1.71,73,85,1.542,1,1,60,0.218978102189781,"strand",-0.333333333333333,5.21,0.0011499209429351,34.1357293868922,34.1353729715529,34.1417078158954,51.1500808664409,66,28,0,4,24,0,0,0,0,2,0,0,2,0,0,0,0,0,0,-1,1,10,0,11,21,-0.685663627152989,-0.345478036175711,0.157212319437059,-0.339641943734015,-0.447643979057592,0.768421052631579,0.494230769230769,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.842,1.712,"2:1","144/150","T:W:E:F:Q:V:N:L:R:I:C:S:A:D:Y:H",3.530334177178,2.90603701922833e-06,0.754772029037902,4.6773516258652,9.53076902254824,217.507266299408,1.53320918696851,1.50118436279358e-09,8.82356596809844,7.82937374234326,309.275011521707,8.55671558873616e-13,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR2515425","ERR2515425","lineage4.1.1.3","za","South Africa","pnca_p.arg154gly","A","E","ARG","RA154","pnca_complex.pdb"
|
|
"R154G","L4","PZA","R","R154",154,"G",NA,"MDR","DM","hydrophilic","hydrophobic","basic","neutral","pos","non-polar",15.259,-2.707,-1.337,4.31639,-1.992,-1.71,73,85,1.542,1,1,60,0.218978102189781,"strand",-0.333333333333333,5.21,0.0011499209429351,34.1357293868922,34.1353729715529,34.1417078158954,51.1500808664409,66,28,0,4,24,0,0,0,0,2,0,0,2,0,0,0,0,0,0,-1,1,10,0,11,21,-0.685663627152989,-0.345478036175711,0.157212319437059,-0.339641943734015,-0.447643979057592,0.768421052631579,0.494230769230769,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.842,1.712,"2:1","144/150","T:W:E:F:Q:V:N:L:R:I:C:S:A:D:Y:H",3.530334177178,2.90603701922833e-06,0.754772029037902,4.6773516258652,9.53076902254824,217.507266299408,1.53320918696851,1.50118436279358e-09,8.82356596809844,7.82937374234326,309.275011521707,8.55671558873616e-13,"lineage4","dr_mutations_pyrazinamide","GLY",0,"SAMN02403546","SRR1167366_SRR1165631_SRR1169261_SRR1169204","lineage4.1.1.3","za","South Africa","pnca_p.arg154gly","A","E","ARG","RA154","pnca_complex.pdb"
|
|
"R154G","L4","PZA","R","R154",154,"G",NA,"MDR","DM","hydrophilic","hydrophobic","basic","neutral","pos","non-polar",15.259,-2.707,-1.337,4.31639,-1.992,-1.71,73,85,1.542,1,1,60,0.218978102189781,"strand",-0.333333333333333,5.21,0.0011499209429351,34.1357293868922,34.1353729715529,34.1417078158954,51.1500808664409,66,28,0,4,24,0,0,0,0,2,0,0,2,0,0,0,0,0,0,-1,1,10,0,11,21,-0.685663627152989,-0.345478036175711,0.157212319437059,-0.339641943734015,-0.447643979057592,0.768421052631579,0.494230769230769,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.842,1.712,"2:1","144/150","T:W:E:F:Q:V:N:L:R:I:C:S:A:D:Y:H",3.530334177178,2.90603701922833e-06,0.754772029037902,4.6773516258652,9.53076902254824,217.507266299408,1.53320918696851,1.50118436279358e-09,8.82356596809844,7.82937374234326,309.275011521707,8.55671558873616e-13,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR551241","ERR551241","lineage4.1.1.3","sz","Swaziland","pnca_p.arg154gly","A","E","ARG","RA154","pnca_complex.pdb"
|
|
"R154G","L2","PZA","R","R154",154,"G",NA,"MDR","DM","hydrophilic","hydrophobic","basic","neutral","pos","non-polar",15.259,-2.707,-1.337,4.31639,-1.992,-1.71,73,85,1.542,1,1,60,0.218978102189781,"strand",-0.333333333333333,5.21,0.0011499209429351,34.1357293868922,34.1353729715529,34.1417078158954,51.1500808664409,66,28,0,4,24,0,0,0,0,2,0,0,2,0,0,0,0,0,0,-1,1,10,0,11,21,-0.685663627152989,-0.345478036175711,0.157212319437059,-0.339641943734015,-0.447643979057592,0.768421052631579,0.494230769230769,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.842,1.712,"2:1","144/150","T:W:E:F:Q:V:N:L:R:I:C:S:A:D:Y:H",3.530334177178,2.90603701922833e-06,0.754772029037902,4.6773516258652,9.53076902254824,217.507266299408,1.53320918696851,1.50118436279358e-09,8.82356596809844,7.82937374234326,309.275011521707,8.55671558873616e-13,"lineage2","dr_mutations_pyrazinamide","GLY",0,"ERR502886","ERR502886","lineage2.2.1","","","pnca_p.arg154gly","A","E","ARG","RA154","pnca_complex.pdb"
|
|
"R154G","L4","PZA","R","R154",154,"G",NA,"XDR","DM","hydrophilic","hydrophobic","basic","neutral","pos","non-polar",15.259,-2.707,-1.337,4.31639,-1.992,-1.71,73,85,1.542,1,1,60,0.218978102189781,"strand",-0.333333333333333,5.21,0.0011499209429351,34.1357293868922,34.1353729715529,34.1417078158954,51.1500808664409,66,28,0,4,24,0,0,0,0,2,0,0,2,0,0,0,0,0,0,-1,1,10,0,11,21,-0.685663627152989,-0.345478036175711,0.157212319437059,-0.339641943734015,-0.447643979057592,0.768421052631579,0.494230769230769,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.842,1.712,"2:1","144/150","T:W:E:F:Q:V:N:L:R:I:C:S:A:D:Y:H",3.530334177178,2.90603701922833e-06,0.754772029037902,4.6773516258652,9.53076902254824,217.507266299408,1.53320918696851,1.50118436279358e-09,8.82356596809844,7.82937374234326,309.275011521707,8.55671558873616e-13,"lineage4","dr_mutations_pyrazinamide","GLY",0,"SAMN02585992","SRR1173554_SRR1173441_SRR1184339_SRR1196541","lineage4.1.1.3","za","South Africa","pnca_p.arg154gly","A","E","ARG","RA154","pnca_complex.pdb"
|
|
"R154G","L4","PZA","R","R154",154,"G",NA,"MDR","DM","hydrophilic","hydrophobic","basic","neutral","pos","non-polar",15.259,-2.707,-1.337,4.31639,-1.992,-1.71,73,85,1.542,1,1,60,0.218978102189781,"strand",-0.333333333333333,5.21,0.0011499209429351,34.1357293868922,34.1353729715529,34.1417078158954,51.1500808664409,66,28,0,4,24,0,0,0,0,2,0,0,2,0,0,0,0,0,0,-1,1,10,0,11,21,-0.685663627152989,-0.345478036175711,0.157212319437059,-0.339641943734015,-0.447643979057592,0.768421052631579,0.494230769230769,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.842,1.712,"2:1","144/150","T:W:E:F:Q:V:N:L:R:I:C:S:A:D:Y:H",3.530334177178,2.90603701922833e-06,0.754772029037902,4.6773516258652,9.53076902254824,217.507266299408,1.53320918696851,1.50118436279358e-09,8.82356596809844,7.82937374234326,309.275011521707,8.55671558873616e-13,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR550813","ERR550813","lineage4.1.1.3","sz","Swaziland","pnca_p.arg154gly","A","E","ARG","RA154","pnca_complex.pdb"
|
|
"R154G","L4","PZA","R","R154",154,"G",NA,"Pre-XDR","DM","hydrophilic","hydrophobic","basic","neutral","pos","non-polar",15.259,-2.707,-1.337,4.31639,-1.992,-1.71,73,85,1.542,1,1,60,0.218978102189781,"strand",-0.333333333333333,5.21,0.0011499209429351,34.1357293868922,34.1353729715529,34.1417078158954,51.1500808664409,66,28,0,4,24,0,0,0,0,2,0,0,2,0,0,0,0,0,0,-1,1,10,0,11,21,-0.685663627152989,-0.345478036175711,0.157212319437059,-0.339641943734015,-0.447643979057592,0.768421052631579,0.494230769230769,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.842,1.712,"2:1","144/150","T:W:E:F:Q:V:N:L:R:I:C:S:A:D:Y:H",3.530334177178,2.90603701922833e-06,0.754772029037902,4.6773516258652,9.53076902254824,217.507266299408,1.53320918696851,1.50118436279358e-09,8.82356596809844,7.82937374234326,309.275011521707,8.55671558873616e-13,"lineage4","dr_mutations_pyrazinamide","GLY",0,"SAMN02585963","SRR1180152_SRR1180940_SRR1183090_SRR1184019","lineage4.1.1.3","za","South Africa","pnca_p.arg154gly","A","E","ARG","RA154","pnca_complex.pdb"
|
|
"R154S","L2","PZA","R","R154",154,"S",NA,"MDR","OM","hydrophilic","hydrophilic","basic","neutral","pos","polar",15.259,-2.614,-2.044,2.37151,-1.076,-1.74,55,75,1.542,1,1,60,0.218978102189781,"strand",-0.333333333333333,5.21,NA,NA,NA,NA,NA,60,28,0,4,24,0,0,0,0,0,0,0,0,0,0,0,0,3,0,0,3,10,0,4,6,-0.662107396149949,-0.528165374677003,0.0863755563487496,-0.183461210571185,-0.455497382198953,0.578947368421053,0.494230769230769,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.842,1.712,"2:1","144/150","T:W:E:F:Q:V:N:L:R:I:C:S:A:D:Y:H",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage2","other_mutations_pyrazinamide","SER",0,"ERR1023404","ERR1023404","lineage2.2.1","","","pnca_p.arg154ser","A","E","ARG","RA154","pnca_complex.pdb"
|
|
"R154S","L2","PZA","R","R154",154,"S",NA,"MDR","OM","hydrophilic","hydrophilic","basic","neutral","pos","polar",15.259,-2.614,-2.044,2.37151,-1.076,-1.74,55,75,1.542,1,1,60,0.218978102189781,"strand",-0.333333333333333,5.21,NA,NA,NA,NA,NA,60,28,0,4,24,0,0,0,0,0,0,0,0,0,0,0,0,3,0,0,3,10,0,4,6,-0.662107396149949,-0.528165374677003,0.0863755563487496,-0.183461210571185,-0.455497382198953,0.578947368421053,0.494230769230769,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.842,1.712,"2:1","144/150","T:W:E:F:Q:V:N:L:R:I:C:S:A:D:Y:H",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage2","other_mutations_pyrazinamide","SER",0,"SAMN02414922","SRR1144728_SRR1166867_SRR1162860_SRR1146272","lineage2.2.1","se","Sweden","pnca_p.arg154ser","A","E","ARG","RA154","pnca_complex.pdb"
|
|
"R154S","L2","PZA","R","R154",154,"S",NA,"MDR","OM","hydrophilic","hydrophilic","basic","neutral","pos","polar",15.259,-2.614,-2.044,2.37151,-1.076,-1.74,55,75,1.542,1,1,60,0.218978102189781,"strand",-0.333333333333333,5.21,NA,NA,NA,NA,NA,60,28,0,4,24,0,0,0,0,0,0,0,0,0,0,0,0,3,0,0,3,10,0,4,6,-0.662107396149949,-0.528165374677003,0.0863755563487496,-0.183461210571185,-0.455497382198953,0.578947368421053,0.494230769230769,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.842,1.712,"2:1","144/150","T:W:E:F:Q:V:N:L:R:I:C:S:A:D:Y:H",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage2","other_mutations_pyrazinamide","SER",0,"SAMN02414920","SRR1163321_SRR1144802_SRR1146413_SRR1163418","lineage2.2.1","se","Sweden","pnca_p.arg154ser","A","E","ARG","RA154","pnca_complex.pdb"
|
|
"R154W","L2","PZA","R","R154",154,"W",NA,"MDR","OM","hydrophilic","hydrophobic","basic","non-polar","pos","non-polar",15.259,-1.381,-0.436,2.7463,-0.368,-0.6,56,75,1.542,1,1,60,0.218978102189781,"strand",-0.333333333333333,5.21,NA,NA,NA,NA,NA,10,28,0,4,24,0,0,0,0,2,0,0,2,0,0,0,0,-4,0,-3,-1,10,0,4,6,-0.349797365754813,-0.11266149870801,0.100026223967249,-0.0627450980392157,-0.157068062827225,0.589473684210526,0.494230769230769,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.842,1.712,"2:1","144/150","T:W:E:F:Q:V:N:L:R:I:C:S:A:D:Y:H",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage2","other_mutations_pyrazinamide","TRP",0,"SRS796973","SRR1723461","lineage2.2.1","cn","China:Shaanxi","pnca_p.arg154trp","A","E","ARG","RA154","pnca_complex.pdb"
|
|
"V155A","L2;L4","PZA","V","V155",155,"A",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",12.302,-1.886,-3.049,3.6527,-2.972,-2.61,54,75,-0.482,7,7,0,0,"strand",1.16666666666667,7.97,7.18700589334483e-05,9.70142977291842,188179.926264589,Inf,0.763784339928386,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,2,3,-0.477710233029382,-0.787855297157623,0.133039284959826,-0.506734867860188,-0.683246073298429,0.568421052631579,-0.397034596375618,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.615,-0.411,"7:7","144/150","F:Y:I:L:V",12.1451538387262,0.919026337424226,119.468044436217,0.101660271548266,5.0115366606409e-06,NA,0.986835744238421,0.170978870202674,0.767057556984365,0.124324963210678,Inf,0.382146811758261,"lineage2;lineage4","dr_mutations_pyrazinamide","ALA",0,"ERR1213939","ERR1213939","lineage4.3;lineage2.2.1","pe","Peru","pnca_p.val155ala","A","E","VAL","VA155","pnca_complex.pdb"
|
|
"V155A","L4","PZA","V","V155",155,"A",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",12.302,-1.886,-3.049,3.6527,-2.972,-2.61,54,75,-0.482,7,7,0,0,"strand",1.16666666666667,7.97,7.18700589334483e-05,9.70142977291842,188179.926264589,Inf,0.763784339928386,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,2,3,-0.477710233029382,-0.787855297157623,0.133039284959826,-0.506734867860188,-0.683246073298429,0.568421052631579,-0.397034596375618,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.615,-0.411,"7:7","144/150","F:Y:I:L:V",12.1451538387262,0.919026337424226,119.468044436217,0.101660271548266,5.0115366606409e-06,NA,0.986835744238421,0.170978870202674,0.767057556984365,0.124324963210678,Inf,0.382146811758261,"lineage4","dr_mutations_pyrazinamide","ALA",0,"ERR1035335","ERR1035335","lineage4.3.3","br","Brazil","pnca_p.val155ala","A","E","VAL","VA155","pnca_complex.pdb"
|
|
"V155A","L4","PZA","V","V155",155,"A",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",12.302,-1.886,-3.049,3.6527,-2.972,-2.61,54,75,-0.482,7,7,0,0,"strand",1.16666666666667,7.97,7.18700589334483e-05,9.70142977291842,188179.926264589,Inf,0.763784339928386,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,2,3,-0.477710233029382,-0.787855297157623,0.133039284959826,-0.506734867860188,-0.683246073298429,0.568421052631579,-0.397034596375618,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.615,-0.411,"7:7","144/150","F:Y:I:L:V",12.1451538387262,0.919026337424226,119.468044436217,0.101660271548266,5.0115366606409e-06,NA,0.986835744238421,0.170978870202674,0.767057556984365,0.124324963210678,Inf,0.382146811758261,"lineage4","dr_mutations_pyrazinamide","ALA",0,"ERR1035263","ERR1035263","lineage4.3.3","br","Brazil","pnca_p.val155ala","A","E","VAL","VA155","pnca_complex.pdb"
|
|
"V155A","L2","PZA","V","V155",155,"A",NA,"Pre-MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",12.302,-1.886,-3.049,3.6527,-2.972,-2.61,54,75,-0.482,7,7,0,0,"strand",1.16666666666667,7.97,7.18700589334483e-05,9.70142977291842,188179.926264589,Inf,0.763784339928386,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,2,3,-0.477710233029382,-0.787855297157623,0.133039284959826,-0.506734867860188,-0.683246073298429,0.568421052631579,-0.397034596375618,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.615,-0.411,"7:7","144/150","F:Y:I:L:V",12.1451538387262,0.919026337424226,119.468044436217,0.101660271548266,5.0115366606409e-06,NA,0.986835744238421,0.170978870202674,0.767057556984365,0.124324963210678,Inf,0.382146811758261,"lineage2","dr_mutations_pyrazinamide","ALA",0,"BGI_SH292,SRR671813","SRR671813","lineage2.2.2","cn","China","pnca_p.val155ala","A","E","VAL","VA155","pnca_complex.pdb"
|
|
"V155A","L4","PZA","V","V155",155,"A",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",12.302,-1.886,-3.049,3.6527,-2.972,-2.61,54,75,-0.482,7,7,0,0,"strand",1.16666666666667,7.97,7.18700589334483e-05,9.70142977291842,188179.926264589,Inf,0.763784339928386,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,2,3,-0.477710233029382,-0.787855297157623,0.133039284959826,-0.506734867860188,-0.683246073298429,0.568421052631579,-0.397034596375618,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.615,-0.411,"7:7","144/150","F:Y:I:L:V",12.1451538387262,0.919026337424226,119.468044436217,0.101660271548266,5.0115366606409e-06,NA,0.986835744238421,0.170978870202674,0.767057556984365,0.124324963210678,Inf,0.382146811758261,"lineage4","dr_mutations_pyrazinamide","ALA",0,"ERR2517044","ERR2517044","lineage4.3.3","gb","UK","pnca_p.val155ala","A","E","VAL","VA155","pnca_complex.pdb"
|
|
"V155A","L2","PZA","V","V155",155,"A",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",12.302,-1.886,-3.049,3.6527,-2.972,-2.61,54,75,-0.482,7,7,0,0,"strand",1.16666666666667,7.97,7.18700589334483e-05,9.70142977291842,188179.926264589,Inf,0.763784339928386,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,2,3,-0.477710233029382,-0.787855297157623,0.133039284959826,-0.506734867860188,-0.683246073298429,0.568421052631579,-0.397034596375618,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.615,-0.411,"7:7","144/150","F:Y:I:L:V",12.1451538387262,0.919026337424226,119.468044436217,0.101660271548266,5.0115366606409e-06,NA,0.986835744238421,0.170978870202674,0.767057556984365,0.124324963210678,Inf,0.382146811758261,"lineage2","dr_mutations_pyrazinamide","ALA",0,"SRR8237402","SRR8237402","lineage2.2.1","us","","pnca_p.val155ala","A","E","VAL","VA155","pnca_complex.pdb"
|
|
"V155A","L2","PZA","V","V155",155,"A",1,"Pre-MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",12.302,-1.886,-3.049,3.6527,-2.972,-2.61,54,75,-0.482,7,7,0,0,"strand",1.16666666666667,7.97,7.18700589334483e-05,9.70142977291842,188179.926264589,Inf,0.763784339928386,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,2,3,-0.477710233029382,-0.787855297157623,0.133039284959826,-0.506734867860188,-0.683246073298429,0.568421052631579,-0.397034596375618,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.615,-0.411,"7:7","144/150","F:Y:I:L:V",12.1451538387262,0.919026337424226,119.468044436217,0.101660271548266,5.0115366606409e-06,NA,0.986835744238421,0.170978870202674,0.767057556984365,0.124324963210678,Inf,0.382146811758261,"lineage2","dr_mutations_pyrazinamide","ALA",0,"ERR551196,SAMEA2533767","ERR551196","lineage2.2.1","","","pnca_p.val155ala","A","E","VAL","VA155","pnca_complex.pdb"
|
|
"V155A","L4","PZA","V","V155",155,"A",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",12.302,-1.886,-3.049,3.6527,-2.972,-2.61,54,75,-0.482,7,7,0,0,"strand",1.16666666666667,7.97,7.18700589334483e-05,9.70142977291842,188179.926264589,Inf,0.763784339928386,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,2,3,-0.477710233029382,-0.787855297157623,0.133039284959826,-0.506734867860188,-0.683246073298429,0.568421052631579,-0.397034596375618,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.615,-0.411,"7:7","144/150","F:Y:I:L:V",12.1451538387262,0.919026337424226,119.468044436217,0.101660271548266,5.0115366606409e-06,NA,0.986835744238421,0.170978870202674,0.767057556984365,0.124324963210678,Inf,0.382146811758261,"lineage4","dr_mutations_pyrazinamide","ALA",0,"ERR3148225","ERR3148225","lineage4.1.2","mx","Mexico","pnca_p.val155ala","A","E","VAL","VA155","pnca_complex.pdb"
|
|
"V155G","L2","PZA","V","V155",155,"G",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",12.302,-1.655,-3.675,5.87683,-4.368,-3.48,72,85,-0.482,7,7,0,0,"strand",1.16666666666667,7.97,0.0004312203536006,24.2923336141533,24.2923334241601,24.2833096922897,14.1977442691074,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,6,0,3,25,-0.41919959473151,-0.949612403100775,0.214046940901376,-0.744757033248082,-0.910994764397906,0.757894736842105,-0.397034596375618,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.615,-0.411,"7:7","144/150","F:Y:I:L:V",3.19016080361873,0.0035954281300594,1.09565968954934,2.91163472932996,3.91551977432402,465.531063220228,1.38546923679232,0.0007494070007895,3.12528225414311,2.71567844828345,1141.60089496884,0.0001645676755807,"lineage2","dr_mutations_pyrazinamide","GLY",0,"SAMN03653311,SRS935922","SRR2024894","lineage2.2.1","cn","China","pnca_p.val155gly","A","E","VAL","VA155","pnca_complex.pdb"
|
|
"V155G","L2","PZA","V","V155",155,"G",0,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",12.302,-1.655,-3.675,5.87683,-4.368,-3.48,72,85,-0.482,7,7,0,0,"strand",1.16666666666667,7.97,0.0004312203536006,24.2923336141533,24.2923334241601,24.2833096922897,14.1977442691074,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,6,0,3,25,-0.41919959473151,-0.949612403100775,0.214046940901376,-0.744757033248082,-0.910994764397906,0.757894736842105,-0.397034596375618,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.615,-0.411,"7:7","144/150","F:Y:I:L:V",3.19016080361873,0.0035954281300594,1.09565968954934,2.91163472932996,3.91551977432402,465.531063220228,1.38546923679232,0.0007494070007895,3.12528225414311,2.71567844828345,1141.60089496884,0.0001645676755807,"lineage2","dr_mutations_pyrazinamide","GLY",0,"ERS458446","ERR552978_ERR552977","lineage2.2.1","uz","Nukus","pnca_p.val155gly","A","E","VAL","VA155","pnca_complex.pdb"
|
|
"V155G","L2","PZA","V","V155",155,"G",1,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",12.302,-1.655,-3.675,5.87683,-4.368,-3.48,72,85,-0.482,7,7,0,0,"strand",1.16666666666667,7.97,0.0004312203536006,24.2923336141533,24.2923334241601,24.2833096922897,14.1977442691074,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,6,0,3,25,-0.41919959473151,-0.949612403100775,0.214046940901376,-0.744757033248082,-0.910994764397906,0.757894736842105,-0.397034596375618,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.615,-0.411,"7:7","144/150","F:Y:I:L:V",3.19016080361873,0.0035954281300594,1.09565968954934,2.91163472932996,3.91551977432402,465.531063220228,1.38546923679232,0.0007494070007895,3.12528225414311,2.71567844828345,1141.60089496884,0.0001645676755807,"lineage2","dr_mutations_pyrazinamide","GLY",0,"ERR2510680","ERR2510680","lineage2.2.1","it","Italy","pnca_p.val155gly","A","E","VAL","VA155","pnca_complex.pdb"
|
|
"V155G","L2","PZA","V","V155",155,"G",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",12.302,-1.655,-3.675,5.87683,-4.368,-3.48,72,85,-0.482,7,7,0,0,"strand",1.16666666666667,7.97,0.0004312203536006,24.2923336141533,24.2923334241601,24.2833096922897,14.1977442691074,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,6,0,3,25,-0.41919959473151,-0.949612403100775,0.214046940901376,-0.744757033248082,-0.910994764397906,0.757894736842105,-0.397034596375618,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.615,-0.411,"7:7","144/150","F:Y:I:L:V",3.19016080361873,0.0035954281300594,1.09565968954934,2.91163472932996,3.91551977432402,465.531063220228,1.38546923679232,0.0007494070007895,3.12528225414311,2.71567844828345,1141.60089496884,0.0001645676755807,"lineage2","dr_mutations_pyrazinamide","GLY",0,"SAMN03653307,SRS935930","SRR2024889","lineage2.2.1","cn","China","pnca_p.val155gly","A","E","VAL","VA155","pnca_complex.pdb"
|
|
"V155G","L2","PZA","V","V155",155,"G",1,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",12.302,-1.655,-3.675,5.87683,-4.368,-3.48,72,85,-0.482,7,7,0,0,"strand",1.16666666666667,7.97,0.0004312203536006,24.2923336141533,24.2923334241601,24.2833096922897,14.1977442691074,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,6,0,3,25,-0.41919959473151,-0.949612403100775,0.214046940901376,-0.744757033248082,-0.910994764397906,0.757894736842105,-0.397034596375618,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.615,-0.411,"7:7","144/150","F:Y:I:L:V",3.19016080361873,0.0035954281300594,1.09565968954934,2.91163472932996,3.91551977432402,465.531063220228,1.38546923679232,0.0007494070007895,3.12528225414311,2.71567844828345,1141.60089496884,0.0001645676755807,"lineage2","dr_mutations_pyrazinamide","GLY",0,"1048Q-sc-2012-02-09T18:57:40Z-1355317,ERR133984","ERR133984","lineage2.2.1","ru","Russia,Samara","pnca_p.val155gly","A","E","VAL","VA155","pnca_complex.pdb"
|
|
"V155G","L2","PZA","V","V155",155,"G",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",12.302,-1.655,-3.675,5.87683,-4.368,-3.48,72,85,-0.482,7,7,0,0,"strand",1.16666666666667,7.97,0.0004312203536006,24.2923336141533,24.2923334241601,24.2833096922897,14.1977442691074,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,6,0,3,25,-0.41919959473151,-0.949612403100775,0.214046940901376,-0.744757033248082,-0.910994764397906,0.757894736842105,-0.397034596375618,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.615,-0.411,"7:7","144/150","F:Y:I:L:V",3.19016080361873,0.0035954281300594,1.09565968954934,2.91163472932996,3.91551977432402,465.531063220228,1.38546923679232,0.0007494070007895,3.12528225414311,2.71567844828345,1141.60089496884,0.0001645676755807,"lineage2","dr_mutations_pyrazinamide","GLY",0,"BGI_SH390,SRR671822","SRR671822","lineage2.2.1","cn","China","pnca_p.val155gly","A","E","VAL","VA155","pnca_complex.pdb"
|
|
"V155G","L4","PZA","V","V155",155,"G",1,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",12.302,-1.655,-3.675,5.87683,-4.368,-3.48,72,85,-0.482,7,7,0,0,"strand",1.16666666666667,7.97,0.0004312203536006,24.2923336141533,24.2923334241601,24.2833096922897,14.1977442691074,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,6,0,3,25,-0.41919959473151,-0.949612403100775,0.214046940901376,-0.744757033248082,-0.910994764397906,0.757894736842105,-0.397034596375618,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.615,-0.411,"7:7","144/150","F:Y:I:L:V",3.19016080361873,0.0035954281300594,1.09565968954934,2.91163472932996,3.91551977432402,465.531063220228,1.38546923679232,0.0007494070007895,3.12528225414311,2.71567844828345,1141.60089496884,0.0001645676755807,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR2516496","ERR2516496","lineage4.3.3","pe","Peru","pnca_p.val155gly","A","E","VAL","VA155","pnca_complex.pdb"
|
|
"V155G","L4","PZA","V","V155",155,"G",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",12.302,-1.655,-3.675,5.87683,-4.368,-3.48,72,85,-0.482,7,7,0,0,"strand",1.16666666666667,7.97,0.0004312203536006,24.2923336141533,24.2923334241601,24.2833096922897,14.1977442691074,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,6,0,3,25,-0.41919959473151,-0.949612403100775,0.214046940901376,-0.744757033248082,-0.910994764397906,0.757894736842105,-0.397034596375618,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.615,-0.411,"7:7","144/150","F:Y:I:L:V",3.19016080361873,0.0035954281300594,1.09565968954934,2.91163472932996,3.91551977432402,465.531063220228,1.38546923679232,0.0007494070007895,3.12528225414311,2.71567844828345,1141.60089496884,0.0001645676755807,"lineage4","dr_mutations_pyrazinamide","GLY",0,"OU17-FMR346","SRR5341253","lineage4.2.2","in","India","pnca_p.val155gly","A","E","VAL","VA155","pnca_complex.pdb"
|
|
"V155G","L2","PZA","V","V155",155,"G",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",12.302,-1.655,-3.675,5.87683,-4.368,-3.48,72,85,-0.482,7,7,0,0,"strand",1.16666666666667,7.97,0.0004312203536006,24.2923336141533,24.2923334241601,24.2833096922897,14.1977442691074,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,6,0,3,25,-0.41919959473151,-0.949612403100775,0.214046940901376,-0.744757033248082,-0.910994764397906,0.757894736842105,-0.397034596375618,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.615,-0.411,"7:7","144/150","F:Y:I:L:V",3.19016080361873,0.0035954281300594,1.09565968954934,2.91163472932996,3.91551977432402,465.531063220228,1.38546923679232,0.0007494070007895,3.12528225414311,2.71567844828345,1141.60089496884,0.0001645676755807,"lineage2","dr_mutations_pyrazinamide","GLY",0,"ERR1034877","ERR1034877","lineage2.2.1","pt","Portugal","pnca_p.val155gly","A","E","VAL","VA155","pnca_complex.pdb"
|
|
"V155G","L2","PZA","V","V155",155,"G",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",12.302,-1.655,-3.675,5.87683,-4.368,-3.48,72,85,-0.482,7,7,0,0,"strand",1.16666666666667,7.97,0.0004312203536006,24.2923336141533,24.2923334241601,24.2833096922897,14.1977442691074,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,6,0,3,25,-0.41919959473151,-0.949612403100775,0.214046940901376,-0.744757033248082,-0.910994764397906,0.757894736842105,-0.397034596375618,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.615,-0.411,"7:7","144/150","F:Y:I:L:V",3.19016080361873,0.0035954281300594,1.09565968954934,2.91163472932996,3.91551977432402,465.531063220228,1.38546923679232,0.0007494070007895,3.12528225414311,2.71567844828345,1141.60089496884,0.0001645676755807,"lineage2","dr_mutations_pyrazinamide","GLY",0,"SRS936010,SAMN03653257","SRR2024954","lineage2.2.1","cn","China","pnca_p.val155gly","A","E","VAL","VA155","pnca_complex.pdb"
|
|
"V155G","L2","PZA","V","V155",155,"G",1,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",12.302,-1.655,-3.675,5.87683,-4.368,-3.48,72,85,-0.482,7,7,0,0,"strand",1.16666666666667,7.97,0.0004312203536006,24.2923336141533,24.2923334241601,24.2833096922897,14.1977442691074,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,6,0,3,25,-0.41919959473151,-0.949612403100775,0.214046940901376,-0.744757033248082,-0.910994764397906,0.757894736842105,-0.397034596375618,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.615,-0.411,"7:7","144/150","F:Y:I:L:V",3.19016080361873,0.0035954281300594,1.09565968954934,2.91163472932996,3.91551977432402,465.531063220228,1.38546923679232,0.0007494070007895,3.12528225414311,2.71567844828345,1141.60089496884,0.0001645676755807,"lineage2","dr_mutations_pyrazinamide","GLY",0,"ERR551494","ERR551494","lineage2.2.1","tm","Turkmenistan","pnca_p.val155gly","A","E","VAL","VA155","pnca_complex.pdb"
|
|
"V155G","L2","PZA","V","V155",155,"G",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",12.302,-1.655,-3.675,5.87683,-4.368,-3.48,72,85,-0.482,7,7,0,0,"strand",1.16666666666667,7.97,0.0004312203536006,24.2923336141533,24.2923334241601,24.2833096922897,14.1977442691074,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,6,0,3,25,-0.41919959473151,-0.949612403100775,0.214046940901376,-0.744757033248082,-0.910994764397906,0.757894736842105,-0.397034596375618,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.615,-0.411,"7:7","144/150","F:Y:I:L:V",3.19016080361873,0.0035954281300594,1.09565968954934,2.91163472932996,3.91551977432402,465.531063220228,1.38546923679232,0.0007494070007895,3.12528225414311,2.71567844828345,1141.60089496884,0.0001645676755807,"lineage2","dr_mutations_pyrazinamide","GLY",0,"SAMN03653239,SRS935968","SRR2024934","lineage2.2.1","cn","China","pnca_p.val155gly","A","E","VAL","VA155","pnca_complex.pdb"
|
|
"V155G","L2","PZA","V","V155",155,"G",1,"XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",12.302,-1.655,-3.675,5.87683,-4.368,-3.48,72,85,-0.482,7,7,0,0,"strand",1.16666666666667,7.97,0.0004312203536006,24.2923336141533,24.2923334241601,24.2833096922897,14.1977442691074,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,6,0,3,25,-0.41919959473151,-0.949612403100775,0.214046940901376,-0.744757033248082,-0.910994764397906,0.757894736842105,-0.397034596375618,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.615,-0.411,"7:7","144/150","F:Y:I:L:V",3.19016080361873,0.0035954281300594,1.09565968954934,2.91163472932996,3.91551977432402,465.531063220228,1.38546923679232,0.0007494070007895,3.12528225414311,2.71567844828345,1141.60089496884,0.0001645676755807,"lineage2","dr_mutations_pyrazinamide","GLY",0,"ERR2516352","ERR2516352","lineage2.2.1","be","Belgium","pnca_p.val155gly","A","E","VAL","VA155","pnca_complex.pdb"
|
|
"V155L","L4","PZA","V","V155",155,"L",1,"MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",12.302,-2.349,-1.141,-0.756754,-1.463,-1.05,-14,57,-0.482,7,7,0,0,"strand",1.16666666666667,7.97,7.18700589334483e-05,9.70142977291842,188179.926264586,Inf,0.763784339928386,-34,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-6,0,-2,-4,-8,0,-8,-2,-0.594984802431611,-0.294832041343669,-0.145496039375529,-0.249445865302643,-0.274869109947644,-0.150537634408602,-0.397034596375618,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","neutral",-0.615,-0.411,"7:7","144/150","F:Y:I:L:V",12.1451538387262,0.919026337424224,119.468044436215,0.101660271548268,5.01153666064309e-06,NA,0.986835744238421,0.170978870202674,0.767057556984365,0.124324963210678,Inf,0.382146811758261,"lineage4","dr_mutations_pyrazinamide","LEU",0,"ERR2864270","ERR2864270","lineage4.1","pt","Portugal","pnca_p.val155leu","A","E","VAL","VA155","pnca_complex.pdb"
|
|
"V155M","L2","PZA","V","V155",155,"M",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",12.302,-2.486,-1.505,-0.575554,-2.196,-1.23,51,75,-0.482,7,7,0,0,"strand",1.16666666666667,7.97,0.0004312203536006,58.3312262958281,1393450.94022009,Inf,23.547488635408,-48,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-8,0,0,-8,-4,0,-4,0,-0.629685916919959,-0.388888888888889,-0.110657925094209,-0.374424552429668,-0.321989528795811,0.536842105263158,-0.397034596375618,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.615,-0.411,"7:7","144/150","F:Y:I:L:V",14.1472939191273,0.915018435774946,132.576060676167,0.106710773023222,4.1789618205157,NA,1.7659011066874,2.48532104922106e-05,4.60461750194108,5.71767556863798,Inf,1.21868387173808e-06,"lineage2","dr_mutations_pyrazinamide","MET",0,"SRS797250","SRR1723776","lineage2.2.1","cn","China:Heilongjiang","pnca_p.val155met","A","E","VAL","VA155","pnca_complex.pdb"
|
|
"V155M","L5","PZA","V","V155",155,"M",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",12.302,-2.486,-1.505,-0.575554,-2.196,-1.23,51,75,-0.482,7,7,0,0,"strand",1.16666666666667,7.97,0.0004312203536006,58.3312262958281,1393450.94022009,Inf,23.547488635408,-48,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-8,0,0,-8,-4,0,-4,0,-0.629685916919959,-0.388888888888889,-0.110657925094209,-0.374424552429668,-0.321989528795811,0.536842105263158,-0.397034596375618,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.615,-0.411,"7:7","144/150","F:Y:I:L:V",14.1472939191273,0.915018435774946,132.576060676167,0.106710773023222,4.1789618205157,NA,1.7659011066874,2.48532104922106e-05,4.60461750194108,5.71767556863798,Inf,1.21868387173808e-06,"lineage5","dr_mutations_pyrazinamide","MET",0,"ERR3170404","ERR3170404","lineage5","gh","Ghana","pnca_p.val155met","A","E","VAL","VA155","pnca_complex.pdb"
|
|
"V155M","L4","PZA","V","V155",155,"M",1,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",12.302,-2.486,-1.505,-0.575554,-2.196,-1.23,51,75,-0.482,7,7,0,0,"strand",1.16666666666667,7.97,0.0004312203536006,58.3312262958281,1393450.94022009,Inf,23.547488635408,-48,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-8,0,0,-8,-4,0,-4,0,-0.629685916919959,-0.388888888888889,-0.110657925094209,-0.374424552429668,-0.321989528795811,0.536842105263158,-0.397034596375618,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.615,-0.411,"7:7","144/150","F:Y:I:L:V",14.1472939191273,0.915018435774946,132.576060676167,0.106710773023222,4.1789618205157,NA,1.7659011066874,2.48532104922106e-05,4.60461750194108,5.71767556863798,Inf,1.21868387173808e-06,"lineage4","dr_mutations_pyrazinamide","MET",0,"ERR228001,2225V-sc-2012-10-11T13:37:49Z-1494165","ERR228001","lineage4.2.1","ru","Russia,Samara","pnca_p.val155met","A","E","VAL","VA155","pnca_complex.pdb"
|
|
"V155M","L4","PZA","V","V155",155,"M",NA,"XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",12.302,-2.486,-1.505,-0.575554,-2.196,-1.23,51,75,-0.482,7,7,0,0,"strand",1.16666666666667,7.97,0.0004312203536006,58.3312262958281,1393450.94022009,Inf,23.547488635408,-48,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-8,0,0,-8,-4,0,-4,0,-0.629685916919959,-0.388888888888889,-0.110657925094209,-0.374424552429668,-0.321989528795811,0.536842105263158,-0.397034596375618,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.615,-0.411,"7:7","144/150","F:Y:I:L:V",14.1472939191273,0.915018435774946,132.576060676167,0.106710773023222,4.1789618205157,NA,1.7659011066874,2.48532104922106e-05,4.60461750194108,5.71767556863798,Inf,1.21868387173808e-06,"lineage4","dr_mutations_pyrazinamide","MET",0,"ERR067752,0472P-sc-2011-08-25T12:38:42Z-1262351","ERR067752","lineage4.2.1","ru","Russia","pnca_p.val155met","A","E","VAL","VA155","pnca_complex.pdb"
|
|
"V155M","L4","PZA","V","V155",155,"M",1,"MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",12.302,-2.486,-1.505,-0.575554,-2.196,-1.23,51,75,-0.482,7,7,0,0,"strand",1.16666666666667,7.97,0.0004312203536006,58.3312262958281,1393450.94022009,Inf,23.547488635408,-48,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-8,0,0,-8,-4,0,-4,0,-0.629685916919959,-0.388888888888889,-0.110657925094209,-0.374424552429668,-0.321989528795811,0.536842105263158,-0.397034596375618,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.615,-0.411,"7:7","144/150","F:Y:I:L:V",14.1472939191273,0.915018435774946,132.576060676167,0.106710773023222,4.1789618205157,NA,1.7659011066874,2.48532104922106e-05,4.60461750194108,5.71767556863798,Inf,1.21868387173808e-06,"lineage4","dr_mutations_pyrazinamide","MET",0,"ERS2592736","ERR2677470","lineage4.3.4.2","de","Germany","pnca_p.val155met","A","E","VAL","VA155","pnca_complex.pdb"
|
|
"V155M","L4","PZA","V","V155",155,"M",1,"XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",12.302,-2.486,-1.505,-0.575554,-2.196,-1.23,51,75,-0.482,7,7,0,0,"strand",1.16666666666667,7.97,0.0004312203536006,58.3312262958281,1393450.94022009,Inf,23.547488635408,-48,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-8,0,0,-8,-4,0,-4,0,-0.629685916919959,-0.388888888888889,-0.110657925094209,-0.374424552429668,-0.321989528795811,0.536842105263158,-0.397034596375618,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.615,-0.411,"7:7","144/150","F:Y:I:L:V",14.1472939191273,0.915018435774946,132.576060676167,0.106710773023222,4.1789618205157,NA,1.7659011066874,2.48532104922106e-05,4.60461750194108,5.71767556863798,Inf,1.21868387173808e-06,"lineage4","dr_mutations_pyrazinamide","MET",0,"ERR234669,2565P-sc-2012-10-11T13:40:44Z-1494347","ERR234669","lineage4.2.1","ru","Russia,Samara","pnca_p.val155met","A","E","VAL","VA155","pnca_complex.pdb"
|
|
"V155M","L2","PZA","V","V155",155,"M",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",12.302,-2.486,-1.505,-0.575554,-2.196,-1.23,51,75,-0.482,7,7,0,0,"strand",1.16666666666667,7.97,0.0004312203536006,58.3312262958281,1393450.94022009,Inf,23.547488635408,-48,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-8,0,0,-8,-4,0,-4,0,-0.629685916919959,-0.388888888888889,-0.110657925094209,-0.374424552429668,-0.321989528795811,0.536842105263158,-0.397034596375618,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.615,-0.411,"7:7","144/150","F:Y:I:L:V",14.1472939191273,0.915018435774946,132.576060676167,0.106710773023222,4.1789618205157,NA,1.7659011066874,2.48532104922106e-05,4.60461750194108,5.71767556863798,Inf,1.21868387173808e-06,"lineage2","dr_mutations_pyrazinamide","MET",0,"SRR1710099","SRR1710099","lineage2.2.1","cn","","pnca_p.val155met","A","E","VAL","VA155","pnca_complex.pdb"
|
|
"V155M","L4","PZA","V","V155",155,"M",1,"MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",12.302,-2.486,-1.505,-0.575554,-2.196,-1.23,51,75,-0.482,7,7,0,0,"strand",1.16666666666667,7.97,0.0004312203536006,58.3312262958281,1393450.94022009,Inf,23.547488635408,-48,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-8,0,0,-8,-4,0,-4,0,-0.629685916919959,-0.388888888888889,-0.110657925094209,-0.374424552429668,-0.321989528795811,0.536842105263158,-0.397034596375618,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.615,-0.411,"7:7","144/150","F:Y:I:L:V",14.1472939191273,0.915018435774946,132.576060676167,0.106710773023222,4.1789618205157,NA,1.7659011066874,2.48532104922106e-05,4.60461750194108,5.71767556863798,Inf,1.21868387173808e-06,"lineage4","dr_mutations_pyrazinamide","MET",0,"ERS2592761","ERR2677413","lineage4.2.1","de","Germany","pnca_p.val155met","A","E","VAL","VA155","pnca_complex.pdb"
|
|
"V155M","L2","PZA","V","V155",155,"M",1,"XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",12.302,-2.486,-1.505,-0.575554,-2.196,-1.23,51,75,-0.482,7,7,0,0,"strand",1.16666666666667,7.97,0.0004312203536006,58.3312262958281,1393450.94022009,Inf,23.547488635408,-48,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-8,0,0,-8,-4,0,-4,0,-0.629685916919959,-0.388888888888889,-0.110657925094209,-0.374424552429668,-0.321989528795811,0.536842105263158,-0.397034596375618,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.615,-0.411,"7:7","144/150","F:Y:I:L:V",14.1472939191273,0.915018435774946,132.576060676167,0.106710773023222,4.1789618205157,NA,1.7659011066874,2.48532104922106e-05,4.60461750194108,5.71767556863798,Inf,1.21868387173808e-06,"lineage2","dr_mutations_pyrazinamide","MET",0,"ERR2510669","ERR2510669","lineage2.2.1","it","Italy","pnca_p.val155met","A","E","VAL","VA155","pnca_complex.pdb"
|
|
"V155M","L2","PZA","V","V155",155,"M",1,"MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",12.302,-2.486,-1.505,-0.575554,-2.196,-1.23,51,75,-0.482,7,7,0,0,"strand",1.16666666666667,7.97,0.0004312203536006,58.3312262958281,1393450.94022009,Inf,23.547488635408,-48,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-8,0,0,-8,-4,0,-4,0,-0.629685916919959,-0.388888888888889,-0.110657925094209,-0.374424552429668,-0.321989528795811,0.536842105263158,-0.397034596375618,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.615,-0.411,"7:7","144/150","F:Y:I:L:V",14.1472939191273,0.915018435774946,132.576060676167,0.106710773023222,4.1789618205157,NA,1.7659011066874,2.48532104922106e-05,4.60461750194108,5.71767556863798,Inf,1.21868387173808e-06,"lineage2","dr_mutations_pyrazinamide","MET",0,"MDR_8213","SRR6824586","lineage2.2.1","cn","China: Bin County, Harbin City, Heilongjiang Province","pnca_p.val155met","A","E","VAL","VA155","pnca_complex.pdb"
|
|
"L156P","L2","PZA","L","L156",156,"P",1,"XDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",13.994,-1.81,-2.813,2.74955,-3.96,-1.74,63,80,0.122,5,5,0,0,"strand",4.06666666666667,6.53,0.0001437401178668,19.411022297013,511754.463553313,Inf,4.73122070382274,18,0,0,0,0,0,0,0,0,2,2,0,0,0,0,0,0,4,2,0,2,0,0,-2,-2,-0.458459979736575,-0.72687338501292,0.100144596041638,-0.675191815856777,-0.455497382198953,0.663157894736842,0.0391025641025641,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.147,0.225,"6:4","144/150","L:V:N:R:I:K:F:H:P",13.1456002256219,0.924803768447042,139.277183326662,0.0943844491368703,0.000162837134443,NA,1.28804840845689,0.0292235860951597,1.53426649183163,0.91081598550184,Inf,0.0296198560706035,"lineage2","dr_mutations_pyrazinamide","PRO",0,"ERR108455,0716E-sc-2011-10-12T14:58:55Z-1289120","ERR108455","lineage2.2.1","ru","Russia,Samara","pnca_p.leu156pro","A","E","LEU","LA156","pnca_complex.pdb"
|
|
"L156P","L2","PZA","L","L156",156,"P",NA,"XDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",13.994,-1.81,-2.813,2.74955,-3.96,-1.74,63,80,0.122,5,5,0,0,"strand",4.06666666666667,6.53,0.0001437401178668,19.411022297013,511754.463553313,Inf,4.73122070382274,18,0,0,0,0,0,0,0,0,2,2,0,0,0,0,0,0,4,2,0,2,0,0,-2,-2,-0.458459979736575,-0.72687338501292,0.100144596041638,-0.675191815856777,-0.455497382198953,0.663157894736842,0.0391025641025641,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.147,0.225,"6:4","144/150","L:V:N:R:I:K:F:H:P",13.1456002256219,0.924803768447042,139.277183326662,0.0943844491368703,0.000162837134443,NA,1.28804840845689,0.0292235860951597,1.53426649183163,0.91081598550184,Inf,0.0296198560706035,"lineage2","dr_mutations_pyrazinamide","PRO",0,"SAMN02419574","SRR1181135_SRR1159361_SRR1159877_SRR1180922","lineage2.2.1","by","Belarus","pnca_p.leu156pro","A","E","LEU","LA156","pnca_complex.pdb"
|
|
"L156P","L3","PZA","L","L156",156,"P",1,"Pre-XDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",13.994,-1.81,-2.813,2.74955,-3.96,-1.74,63,80,0.122,5,5,0,0,"strand",4.06666666666667,6.53,0.0001437401178668,19.411022297013,511754.463553313,Inf,4.73122070382274,18,0,0,0,0,0,0,0,0,2,2,0,0,0,0,0,0,4,2,0,2,0,0,-2,-2,-0.458459979736575,-0.72687338501292,0.100144596041638,-0.675191815856777,-0.455497382198953,0.663157894736842,0.0391025641025641,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.147,0.225,"6:4","144/150","L:V:N:R:I:K:F:H:P",13.1456002256219,0.924803768447042,139.277183326662,0.0943844491368703,0.000162837134443,NA,1.28804840845689,0.0292235860951597,1.53426649183163,0.91081598550184,Inf,0.0296198560706035,"lineage3","dr_mutations_pyrazinamide","PRO",0,"ERR2510294","ERR2510294","lineage3","pk","Pakistan","pnca_p.leu156pro","A","E","LEU","LA156","pnca_complex.pdb"
|
|
"L156P","L2","PZA","L","L156",156,"P",NA,"XDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",13.994,-1.81,-2.813,2.74955,-3.96,-1.74,63,80,0.122,5,5,0,0,"strand",4.06666666666667,6.53,0.0001437401178668,19.411022297013,511754.463553313,Inf,4.73122070382274,18,0,0,0,0,0,0,0,0,2,2,0,0,0,0,0,0,4,2,0,2,0,0,-2,-2,-0.458459979736575,-0.72687338501292,0.100144596041638,-0.675191815856777,-0.455497382198953,0.663157894736842,0.0391025641025641,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.147,0.225,"6:4","144/150","L:V:N:R:I:K:F:H:P",13.1456002256219,0.924803768447042,139.277183326662,0.0943844491368703,0.000162837134443,NA,1.28804840845689,0.0292235860951597,1.53426649183163,0.91081598550184,Inf,0.0296198560706035,"lineage2","dr_mutations_pyrazinamide","PRO",0,"SAMN02419643","SRR1163415_SRR1169001_SRR1172144_SRR1163022","lineage2.2.1","by","Belarus","pnca_p.leu156pro","A","E","LEU","LA156","pnca_complex.pdb"
|
|
"L156Q","L4","PZA","L","L156",156,"Q",1,"Pre-MDR","OM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",13.994,-0.36,-2.863,2.41139,-4.191,-2.69,41,71,0.122,5,5,0,0,"strand",4.06666666666667,6.53,7.18700589334483e-05,9.70142977291842,188179.92626469,Inf,0.763784339928386,-14,0,0,0,0,0,0,0,0,-2,0,0,-2,0,0,0,0,3,0,-2,5,0,0,0,0,-0.0911854103343465,-0.739793281653747,0.0878280727569403,-0.71457800511509,-0.704188481675393,0.431578947368421,0.0391025641025641,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.147,0.225,"6:4","144/150","L:V:N:R:I:K:F:H:P",12.1451538387267,0.919026337424244,119.46804443625,0.101660271548243,5.01153666061033e-06,NA,0.986835744238421,0.170978870202674,0.767057556984365,0.124324963210678,Inf,0.382146811758261,"lineage4","other_mutations_pyrazinamide","GLN",0,"ERR038749","ERR038749","lineage4.6.1.2","ug","Uganda","pnca_p.leu156gln","A","E","LEU","LA156","pnca_complex.pdb"
|
|
"V157A","L2","PZA","V","V157",157,"A",1,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",13.632,-0.931,-1.625,0.858959,-1.03,-1.74,-36,66,0.579,3,3,45,0.258620689655172,"strand",1.5,4.12,7.18700589334483e-05,9.70142977291842,188179.926264427,Inf,0.763784339928386,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,3,0,3,0,2,0,0,5,-0.235815602836879,-0.419896640826873,0.0312851565060934,-0.175618073316283,-0.455497382198953,-0.387096774193548,0.185576923076923,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","neutral",0.225,0.842,"4:2","144/150","Q:F:E:I:R:L:V:T:W:K:P:S:M:G:A:D",12.1451538387253,0.919026337424197,119.468044436166,0.101660271548303,5.01153666068889e-06,NA,0.986835744238421,0.170978870202674,0.767057556984365,0.124324963210678,Inf,0.382146811758261,"lineage2","other_mutations_pyrazinamide","ALA",0,"ERR2516727","ERR2516727","lineage2.2.1.1","pe","Peru","pnca_p.val157ala","A","E","VAL","VA157","pnca_complex.pdb"
|
|
"V157G","L2","PZA","V","V157",157,"G",1,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",13.632,-0.926,-1.896,1.97999,-1.919,-2.35,-7,53,0.579,3,3,45,0.258620689655172,"strand",1.5,4.12,7.18700589334483e-05,9.70142977291842,188179.926264401,Inf,0.763784339928386,-2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,3,0,3,0,2,0,3,17,-0.234549138804458,-0.489922480620155,0.072115545713474,-0.327195225916454,-0.615183246073298,-0.0752688172043011,0.185576923076923,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","neutral",0.225,0.842,"4:2","144/150","Q:F:E:I:R:L:V:T:W:K:P:S:M:G:A:D",12.1451538387252,0.919026337424192,119.468044436158,0.101660271548309,5.01153666069661e-06,NA,0.986835744238421,0.170978870202674,0.767057556984365,0.124324963210678,Inf,0.382146811758261,"lineage2","other_mutations_pyrazinamide","GLY",0,"MDR_12366","SRR6824636","lineage2.2.1","cn","China: Xuanzhou District, Xuancheng City, Anhui Province","pnca_p.val157gly","A","E","VAL","VA157","pnca_complex.pdb"
|
|
"V157G","L2","PZA","V","V157",157,"G",NA,"XDR","OM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",13.632,-0.926,-1.896,1.97999,-1.919,-2.35,-7,53,0.579,3,3,45,0.258620689655172,"strand",1.5,4.12,7.18700589334483e-05,9.70142977291842,188179.926264401,Inf,0.763784339928386,-2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,3,0,3,0,2,0,3,17,-0.234549138804458,-0.489922480620155,0.072115545713474,-0.327195225916454,-0.615183246073298,-0.0752688172043011,0.185576923076923,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","neutral",0.225,0.842,"4:2","144/150","Q:F:E:I:R:L:V:T:W:K:P:S:M:G:A:D",12.1451538387252,0.919026337424192,119.468044436158,0.101660271548309,5.01153666069661e-06,NA,0.986835744238421,0.170978870202674,0.767057556984365,0.124324963210678,Inf,0.382146811758261,"lineage2","other_mutations_pyrazinamide","GLY",0,"SAMN02398716","SRR1144725_SRR1048011","lineage2.2.2","kr","South Korea","pnca_p.val157gly","A","E","VAL","VA157","pnca_complex.pdb"
|
|
"V157G","L4","PZA","V","V157",157,"G",NA,"MDR","OM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",13.632,-0.926,-1.896,1.97999,-1.919,-2.35,-7,53,0.579,3,3,45,0.258620689655172,"strand",1.5,4.12,7.18700589334483e-05,9.70142977291842,188179.926264401,Inf,0.763784339928386,-2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,3,0,3,0,2,0,3,17,-0.234549138804458,-0.489922480620155,0.072115545713474,-0.327195225916454,-0.615183246073298,-0.0752688172043011,0.185576923076923,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","neutral",0.225,0.842,"4:2","144/150","Q:F:E:I:R:L:V:T:W:K:P:S:M:G:A:D",12.1451538387252,0.919026337424192,119.468044436158,0.101660271548309,5.01153666069661e-06,NA,0.986835744238421,0.170978870202674,0.767057556984365,0.124324963210678,Inf,0.382146811758261,"lineage4","other_mutations_pyrazinamide","GLY",0,"SRR3724928","SRR3724928","lineage4.1","ci","Ivory_Coast","pnca_p.val157gly","A","E","VAL","VA157","pnca_complex.pdb"
|
|
"V157G","L2","PZA","V","V157",157,"G",NA,"MDR","OM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",13.632,-0.926,-1.896,1.97999,-1.919,-2.35,-7,53,0.579,3,3,45,0.258620689655172,"strand",1.5,4.12,7.18700589334483e-05,9.70142977291842,188179.926264401,Inf,0.763784339928386,-2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,3,0,3,0,2,0,3,17,-0.234549138804458,-0.489922480620155,0.072115545713474,-0.327195225916454,-0.615183246073298,-0.0752688172043011,0.185576923076923,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","neutral",0.225,0.842,"4:2","144/150","Q:F:E:I:R:L:V:T:W:K:P:S:M:G:A:D",12.1451538387252,0.919026337424192,119.468044436158,0.101660271548309,5.01153666069661e-06,NA,0.986835744238421,0.170978870202674,0.767057556984365,0.124324963210678,Inf,0.382146811758261,"lineage2","other_mutations_pyrazinamide","GLY",0,"SRS797042","SRR1723544","lineage2.2.1","cn","China:Anhui","pnca_p.val157gly","A","E","VAL","VA157","pnca_complex.pdb"
|
|
"V157G","L2","PZA","V","V157",157,"G",NA,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",13.632,-0.926,-1.896,1.97999,-1.919,-2.35,-7,53,0.579,3,3,45,0.258620689655172,"strand",1.5,4.12,7.18700589334483e-05,9.70142977291842,188179.926264401,Inf,0.763784339928386,-2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,3,0,3,0,2,0,3,17,-0.234549138804458,-0.489922480620155,0.072115545713474,-0.327195225916454,-0.615183246073298,-0.0752688172043011,0.185576923076923,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","neutral",0.225,0.842,"4:2","144/150","Q:F:E:I:R:L:V:T:W:K:P:S:M:G:A:D",12.1451538387252,0.919026337424192,119.468044436158,0.101660271548309,5.01153666069661e-06,NA,0.986835744238421,0.170978870202674,0.767057556984365,0.124324963210678,Inf,0.382146811758261,"lineage2","other_mutations_pyrazinamide","GLY",0,"SRS797212","SRR1723734_SRR1723735","lineage2.2.1","cn","China:Anhui","pnca_p.val157gly","A","E","VAL","VA157","pnca_complex.pdb"
|
|
"V157G","L4","PZA","V","V157",157,"G",NA,"MDR","OM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",13.632,-0.926,-1.896,1.97999,-1.919,-2.35,-7,53,0.579,3,3,45,0.258620689655172,"strand",1.5,4.12,7.18700589334483e-05,9.70142977291842,188179.926264401,Inf,0.763784339928386,-2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,3,0,3,0,2,0,3,17,-0.234549138804458,-0.489922480620155,0.072115545713474,-0.327195225916454,-0.615183246073298,-0.0752688172043011,0.185576923076923,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","neutral",0.225,0.842,"4:2","144/150","Q:F:E:I:R:L:V:T:W:K:P:S:M:G:A:D",12.1451538387252,0.919026337424192,119.468044436158,0.101660271548309,5.01153666069661e-06,NA,0.986835744238421,0.170978870202674,0.767057556984365,0.124324963210678,Inf,0.382146811758261,"lineage4","other_mutations_pyrazinamide","GLY",0,"SRR3725718","SRR3725718","lineage4.1","ci","Ivory_Coast","pnca_p.val157gly","A","E","VAL","VA157","pnca_complex.pdb"
|
|
"V157L","L4","PZA","V","V157",157,"L",NA,"Sensitive","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",13.632,-0.972,-0.484,-2.04339,1.184,-0.57,-43,72,0.579,3,3,45,0.258620689655172,"strand",1.5,4.12,NA,NA,NA,NA,NA,-18,0,0,0,0,0,0,0,0,2,0,-2,2,0,0,0,0,-3,0,1,-4,-4,0,-2,-2,-0.246200607902736,-0.125064599483204,-0.392868953318465,1,-0.149214659685864,-0.462365591397849,0.185576923076923,"Destabilising","Destabilising","Stabilising","Stabilising","Destabilising","neutral",0.225,0.842,"4:2","144/150","Q:F:E:I:R:L:V:T:W:K:P:S:M:G:A:D",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage4","other_mutations_pyrazinamide","LEU",0,"ERR1198987","ERR1198987","lineage4.6.1.1","ug","Uganda","pnca_p.val157leu","A","E","VAL","VA157","pnca_complex.pdb"
|
|
"L159P","L4","PZA","L","L159",159,"P",NA,"MDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",11.435,-1.752,-1.412,6.08412,-4.496,-0.94,92,95,-0.599,7,7,6,0.0298507462686567,"strand",-0.133333333333333,5.42,NA,NA,NA,NA,NA,24,4,0,0,4,0,0,0,0,2,2,2,0,0,0,0,0,2,4,-4,0,-4,0,-2,-2,-0.443768996960486,-0.364857881136951,0.221596893916768,-0.766581415174766,-0.246073298429319,0.968421052631579,-0.49341021416804,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.485,"8:7","141/150","G:A:M:H:F:Y:L:V",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR1034843","ERR1034843","lineage4.7","pt","Portugal","pnca_p.leu159pro","A","E","LEU","LA159","pnca_complex.pdb"
|
|
"L159P","L2","PZA","L","L159",159,"P",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",11.435,-1.752,-1.412,6.08412,-4.496,-0.94,92,95,-0.599,7,7,6,0.0298507462686567,"strand",-0.133333333333333,5.42,NA,NA,NA,NA,NA,24,4,0,0,4,0,0,0,0,2,2,2,0,0,0,0,0,2,4,-4,0,-4,0,-2,-2,-0.443768996960486,-0.364857881136951,0.221596893916768,-0.766581415174766,-0.246073298429319,0.968421052631579,-0.49341021416804,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.485,"8:7","141/150","G:A:M:H:F:Y:L:V",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage2","dr_mutations_pyrazinamide","PRO",0,"BGI_252,SRR671867","SRR671867","lineage2.2.1","cn","China","pnca_p.leu159pro","A","E","LEU","LA159","pnca_complex.pdb"
|
|
"L159R","L2","PZA","L","L159",159,"R",NA,"MDR","DM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",11.435,-1.154,-0.753,0.0571381999999999,-4.133,-0.41,89,91,-0.599,7,7,6,0.0298507462686567,"strand",-0.133333333333333,5.42,0.0005030904125341,68.0817875210792,1394038.39846606,Inf,28.35828361563,-56,-26,0,-2,-24,0,0,0,0,-4,0,-2,-2,0,0,0,0,-3,0,0,-5,-4,0,-4,0,-0.292299898682877,-0.194573643410853,0.00208109761871808,-0.704688832054561,-0.107329842931937,0.936842105263158,-0.49341021416804,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.485,"8:7","141/150","G:A:M:H:F:Y:L:V",14.1477154154513,0.908235680147999,122.741582019401,0.115264242017143,22.9578143501753,NA,1.83303094984313,4.24048522418865e-06,5.37258444573496,7.00237574052121,Inf,1.00814491180914e-07,"lineage2","dr_mutations_pyrazinamide","ARG",0,"SRR5065596","SRR5065596","lineage2.2.1","vn","Vietnam","pnca_p.leu159arg","A","E","LEU","LA159","pnca_complex.pdb"
|
|
"L159R","L2","PZA","L","L159",159,"R",NA,"Pre-MDR","DM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",11.435,-1.154,-0.753,0.0571381999999999,-4.133,-0.41,89,91,-0.599,7,7,6,0.0298507462686567,"strand",-0.133333333333333,5.42,0.0005030904125341,68.0817875210792,1394038.39846606,Inf,28.35828361563,-56,-26,0,-2,-24,0,0,0,0,-4,0,-2,-2,0,0,0,0,-3,0,0,-5,-4,0,-4,0,-0.292299898682877,-0.194573643410853,0.00208109761871808,-0.704688832054561,-0.107329842931937,0.936842105263158,-0.49341021416804,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.485,"8:7","141/150","G:A:M:H:F:Y:L:V",14.1477154154513,0.908235680147999,122.741582019401,0.115264242017143,22.9578143501753,NA,1.83303094984313,4.24048522418865e-06,5.37258444573496,7.00237574052121,Inf,1.00814491180914e-07,"lineage2","dr_mutations_pyrazinamide","ARG",0,"DRR184610","DRR184610","lineage2.2.1","vn","Vietnam","pnca_p.leu159arg","A","E","LEU","LA159","pnca_complex.pdb"
|
|
"L159R","L3","PZA","L","L159",159,"R",1,"MDR","DM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",11.435,-1.154,-0.753,0.0571381999999999,-4.133,-0.41,89,91,-0.599,7,7,6,0.0298507462686567,"strand",-0.133333333333333,5.42,0.0005030904125341,68.0817875210792,1394038.39846606,Inf,28.35828361563,-56,-26,0,-2,-24,0,0,0,0,-4,0,-2,-2,0,0,0,0,-3,0,0,-5,-4,0,-4,0,-0.292299898682877,-0.194573643410853,0.00208109761871808,-0.704688832054561,-0.107329842931937,0.936842105263158,-0.49341021416804,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.485,"8:7","141/150","G:A:M:H:F:Y:L:V",14.1477154154513,0.908235680147999,122.741582019401,0.115264242017143,22.9578143501753,NA,1.83303094984313,4.24048522418865e-06,5.37258444573496,7.00237574052121,Inf,1.00814491180914e-07,"lineage3","dr_mutations_pyrazinamide","ARG",0,"ERR2510529","ERR2510529","lineage3","pk","Pakistan","pnca_p.leu159arg","A","E","LEU","LA159","pnca_complex.pdb"
|
|
"L159R","L4","PZA","L","L159",159,"R",1,"Pre-XDR","DM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",11.435,-1.154,-0.753,0.0571381999999999,-4.133,-0.41,89,91,-0.599,7,7,6,0.0298507462686567,"strand",-0.133333333333333,5.42,0.0005030904125341,68.0817875210792,1394038.39846606,Inf,28.35828361563,-56,-26,0,-2,-24,0,0,0,0,-4,0,-2,-2,0,0,0,0,-3,0,0,-5,-4,0,-4,0,-0.292299898682877,-0.194573643410853,0.00208109761871808,-0.704688832054561,-0.107329842931937,0.936842105263158,-0.49341021416804,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.485,"8:7","141/150","G:A:M:H:F:Y:L:V",14.1477154154513,0.908235680147999,122.741582019401,0.115264242017143,22.9578143501753,NA,1.83303094984313,4.24048522418865e-06,5.37258444573496,7.00237574052121,Inf,1.00814491180914e-07,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ETB0008","SRR6256976","lineage4.2.1","ru","Russia:Kalmykia","pnca_p.leu159arg","A","E","LEU","LA159","pnca_complex.pdb"
|
|
"L159R","L4","PZA","L","L159",159,"R",1,"MDR","DM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",11.435,-1.154,-0.753,0.0571381999999999,-4.133,-0.41,89,91,-0.599,7,7,6,0.0298507462686567,"strand",-0.133333333333333,5.42,0.0005030904125341,68.0817875210792,1394038.39846606,Inf,28.35828361563,-56,-26,0,-2,-24,0,0,0,0,-4,0,-2,-2,0,0,0,0,-3,0,0,-5,-4,0,-4,0,-0.292299898682877,-0.194573643410853,0.00208109761871808,-0.704688832054561,-0.107329842931937,0.936842105263158,-0.49341021416804,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.485,"8:7","141/150","G:A:M:H:F:Y:L:V",14.1477154154513,0.908235680147999,122.741582019401,0.115264242017143,22.9578143501753,NA,1.83303094984313,4.24048522418865e-06,5.37258444573496,7.00237574052121,Inf,1.00814491180914e-07,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERR2512878","ERR2512878","lineage4.2.1","gb","UK","pnca_p.leu159arg","A","E","LEU","LA159","pnca_complex.pdb"
|
|
"L159R","L4","PZA","L","L159",159,"R",1,"MDR","DM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",11.435,-1.154,-0.753,0.0571381999999999,-4.133,-0.41,89,91,-0.599,7,7,6,0.0298507462686567,"strand",-0.133333333333333,5.42,0.0005030904125341,68.0817875210792,1394038.39846606,Inf,28.35828361563,-56,-26,0,-2,-24,0,0,0,0,-4,0,-2,-2,0,0,0,0,-3,0,0,-5,-4,0,-4,0,-0.292299898682877,-0.194573643410853,0.00208109761871808,-0.704688832054561,-0.107329842931937,0.936842105263158,-0.49341021416804,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.485,"8:7","141/150","G:A:M:H:F:Y:L:V",14.1477154154513,0.908235680147999,122.741582019401,0.115264242017143,22.9578143501753,NA,1.83303094984313,4.24048522418865e-06,5.37258444573496,7.00237574052121,Inf,1.00814491180914e-07,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERR2512440","ERR2512440","lineage4.2.1","gb","UK","pnca_p.leu159arg","A","E","LEU","LA159","pnca_complex.pdb"
|
|
"L159R","L2","PZA","L","L159",159,"R",NA,"MDR","DM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",11.435,-1.154,-0.753,0.0571381999999999,-4.133,-0.41,89,91,-0.599,7,7,6,0.0298507462686567,"strand",-0.133333333333333,5.42,0.0005030904125341,68.0817875210792,1394038.39846606,Inf,28.35828361563,-56,-26,0,-2,-24,0,0,0,0,-4,0,-2,-2,0,0,0,0,-3,0,0,-5,-4,0,-4,0,-0.292299898682877,-0.194573643410853,0.00208109761871808,-0.704688832054561,-0.107329842931937,0.936842105263158,-0.49341021416804,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.485,"8:7","141/150","G:A:M:H:F:Y:L:V",14.1477154154513,0.908235680147999,122.741582019401,0.115264242017143,22.9578143501753,NA,1.83303094984313,4.24048522418865e-06,5.37258444573496,7.00237574052121,Inf,1.00814491180914e-07,"lineage2","dr_mutations_pyrazinamide","ARG",0,"SRR5065588","SRR5065588","lineage2.2.1","vn","Vietnam","pnca_p.leu159arg","A","E","LEU","LA159","pnca_complex.pdb"
|
|
"L159R","L2","PZA","L","L159",159,"R",1,"Pre-XDR","DM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",11.435,-1.154,-0.753,0.0571381999999999,-4.133,-0.41,89,91,-0.599,7,7,6,0.0298507462686567,"strand",-0.133333333333333,5.42,0.0005030904125341,68.0817875210792,1394038.39846606,Inf,28.35828361563,-56,-26,0,-2,-24,0,0,0,0,-4,0,-2,-2,0,0,0,0,-3,0,0,-5,-4,0,-4,0,-0.292299898682877,-0.194573643410853,0.00208109761871808,-0.704688832054561,-0.107329842931937,0.936842105263158,-0.49341021416804,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.485,"8:7","141/150","G:A:M:H:F:Y:L:V",14.1477154154513,0.908235680147999,122.741582019401,0.115264242017143,22.9578143501753,NA,1.83303094984313,4.24048522418865e-06,5.37258444573496,7.00237574052121,Inf,1.00814491180914e-07,"lineage2","dr_mutations_pyrazinamide","ARG",0,"ERR1035100","ERR1035100","lineage2.2.1.1","vn","Vietnam","pnca_p.leu159arg","A","E","LEU","LA159","pnca_complex.pdb"
|
|
"L159R","L2","PZA","L","L159",159,"R",NA,"MDR","DM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",11.435,-1.154,-0.753,0.0571381999999999,-4.133,-0.41,89,91,-0.599,7,7,6,0.0298507462686567,"strand",-0.133333333333333,5.42,0.0005030904125341,68.0817875210792,1394038.39846606,Inf,28.35828361563,-56,-26,0,-2,-24,0,0,0,0,-4,0,-2,-2,0,0,0,0,-3,0,0,-5,-4,0,-4,0,-0.292299898682877,-0.194573643410853,0.00208109761871808,-0.704688832054561,-0.107329842931937,0.936842105263158,-0.49341021416804,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.485,"8:7","141/150","G:A:M:H:F:Y:L:V",14.1477154154513,0.908235680147999,122.741582019401,0.115264242017143,22.9578143501753,NA,1.83303094984313,4.24048522418865e-06,5.37258444573496,7.00237574052121,Inf,1.00814491180914e-07,"lineage2","dr_mutations_pyrazinamide","ARG",0,"SRR5073854","SRR5073854","lineage2.2.1","vn","Vietnam","pnca_p.leu159arg","A","E","LEU","LA159","pnca_complex.pdb"
|
|
"L159R","L3","PZA","L","L159",159,"R",1,"Pre-XDR","DM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",11.435,-1.154,-0.753,0.0571381999999999,-4.133,-0.41,89,91,-0.599,7,7,6,0.0298507462686567,"strand",-0.133333333333333,5.42,0.0005030904125341,68.0817875210792,1394038.39846606,Inf,28.35828361563,-56,-26,0,-2,-24,0,0,0,0,-4,0,-2,-2,0,0,0,0,-3,0,0,-5,-4,0,-4,0,-0.292299898682877,-0.194573643410853,0.00208109761871808,-0.704688832054561,-0.107329842931937,0.936842105263158,-0.49341021416804,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.485,"8:7","141/150","G:A:M:H:F:Y:L:V",14.1477154154513,0.908235680147999,122.741582019401,0.115264242017143,22.9578143501753,NA,1.83303094984313,4.24048522418865e-06,5.37258444573496,7.00237574052121,Inf,1.00814491180914e-07,"lineage3","dr_mutations_pyrazinamide","ARG",0,"ERR2510496","ERR2510496","lineage3","pk","Pakistan","pnca_p.leu159arg","A","E","LEU","LA159","pnca_complex.pdb"
|
|
"L159R","L4","PZA","L","L159",159,"R",1,"MDR","DM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",11.435,-1.154,-0.753,0.0571381999999999,-4.133,-0.41,89,91,-0.599,7,7,6,0.0298507462686567,"strand",-0.133333333333333,5.42,0.0005030904125341,68.0817875210792,1394038.39846606,Inf,28.35828361563,-56,-26,0,-2,-24,0,0,0,0,-4,0,-2,-2,0,0,0,0,-3,0,0,-5,-4,0,-4,0,-0.292299898682877,-0.194573643410853,0.00208109761871808,-0.704688832054561,-0.107329842931937,0.936842105263158,-0.49341021416804,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.485,"8:7","141/150","G:A:M:H:F:Y:L:V",14.1477154154513,0.908235680147999,122.741582019401,0.115264242017143,22.9578143501753,NA,1.83303094984313,4.24048522418865e-06,5.37258444573496,7.00237574052121,Inf,1.00814491180914e-07,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERR2513608","ERR2513608","lineage4.2.1","gb","UK","pnca_p.leu159arg","A","E","LEU","LA159","pnca_complex.pdb"
|
|
"L159V","L2","PZA","L","L159",159,"V",0,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",11.435,-1.82,-1.126,2.84083,-2.332,-1.09,60,80,-0.599,7,7,6,0.0298507462686567,"strand",-0.133333333333333,5.42,0.0001437401178668,4.85029436501262,4.85029432717735,4.84956447904112,0.0881192621863332,22,4,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,-8,0,-2,-6,10,0,-2,8,-0.460992907801418,-0.290956072351421,0.103469212334006,-0.397612958226769,-0.285340314136126,0.631578947368421,-0.49341021416804,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.485,"8:7","141/150","G:A:M:H:F:Y:L:V",1.57903938912402,0.264247566376723,1.41439286276584,1.11640791656443,0.191756076673846,122.683760399179,0.685768096792206,0.312734154310187,0.504824686014995,0.061763864579114,379.558337204203,0.766581879696361,"lineage2","dr_mutations_pyrazinamide","VAL",0,"ERS458597,SAMEA2535195","ERR553180_ERR553181","lineage2.2.1","uz","Nukus","pnca_p.leu159val","A","E","LEU","LA159","pnca_complex.pdb"
|
|
"L159V","L2","PZA","L","L159",159,"V",1,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",11.435,-1.82,-1.126,2.84083,-2.332,-1.09,60,80,-0.599,7,7,6,0.0298507462686567,"strand",-0.133333333333333,5.42,0.0001437401178668,4.85029436501262,4.85029432717735,4.84956447904112,0.0881192621863332,22,4,0,0,4,0,0,0,0,0,0,0,0,0,0,0,0,-8,0,-2,-6,10,0,-2,8,-0.460992907801418,-0.290956072351421,0.103469212334006,-0.397612958226769,-0.285340314136126,0.631578947368421,-0.49341021416804,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.728,-0.485,"8:7","141/150","G:A:M:H:F:Y:L:V",1.57903938912402,0.264247566376723,1.41439286276584,1.11640791656443,0.191756076673846,122.683760399179,0.685768096792206,0.312734154310187,0.504824686014995,0.061763864579114,379.558337204203,0.766581879696361,"lineage2","dr_mutations_pyrazinamide","VAL",0,"SAMEA2534699,ERS458101","ERR552513_ERR552514","lineage2.2.1","uz","Nukus","pnca_p.leu159val","A","E","LEU","LA159","pnca_complex.pdb"
|
|
"T160A","L2","PZA","T","T160",160,"A",1,"XDR","DM","hydrophobic","hydrophobic","neutral","non-polar","polar","non-polar",9.847,-2.509,-0.842,2.1045,-1.519,-0.73,57,75,-0.228,6,6,22,0.127906976744186,"strand",1.63333333333333,4.98,0.0005749604714675,77.8405735976381,1394626.35224664,Inf,33.1802749271012,8,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,0,0,0,0,2,0,4,3,-0.635511651469098,-0.217571059431524,0.0766504709387452,-0.258994032395567,-0.19109947643979,0.6,-0.187808896210873,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.411,-0.147,"7:6","141/150","V:C:I:M:S:T",14.1481370895081,0.901927875940744,114.814237034519,0.123226330243822,82.9586021395589,NA,1.89120602753485,7.2326389241213e-07,6.1407032156959,8.29603358299821,Inf,8.39983046099388e-09,"lineage2","dr_mutations_pyrazinamide","ALA",0,"ERR1873556","ERR1873556","lineage2.2.1","za","South Africa","pnca_p.thr160ala","A","E","THR","TA160","pnca_complex.pdb"
|
|
"T160A","L2","PZA","T","T160",160,"A",NA,"MDR","DM","hydrophobic","hydrophobic","neutral","non-polar","polar","non-polar",9.847,-2.509,-0.842,2.1045,-1.519,-0.73,57,75,-0.228,6,6,22,0.127906976744186,"strand",1.63333333333333,4.98,0.0005749604714675,77.8405735976381,1394626.35224664,Inf,33.1802749271012,8,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,0,0,0,0,2,0,4,3,-0.635511651469098,-0.217571059431524,0.0766504709387452,-0.258994032395567,-0.19109947643979,0.6,-0.187808896210873,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.411,-0.147,"7:6","141/150","V:C:I:M:S:T",14.1481370895081,0.901927875940744,114.814237034519,0.123226330243822,82.9586021395589,NA,1.89120602753485,7.2326389241213e-07,6.1407032156959,8.29603358299821,Inf,8.39983046099388e-09,"lineage2","dr_mutations_pyrazinamide","ALA",0,"SAMN02584597","SRR1168994_SRR1166227","lineage2.2.1","md","Moldova","pnca_p.thr160ala","A","E","THR","TA160","pnca_complex.pdb"
|
|
"T160A","L4","PZA","T","T160",160,"A",NA,"MDR","DM","hydrophobic","hydrophobic","neutral","non-polar","polar","non-polar",9.847,-2.509,-0.842,2.1045,-1.519,-0.73,57,75,-0.228,6,6,22,0.127906976744186,"strand",1.63333333333333,4.98,0.0005749604714675,77.8405735976381,1394626.35224664,Inf,33.1802749271012,8,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,0,0,0,0,2,0,4,3,-0.635511651469098,-0.217571059431524,0.0766504709387452,-0.258994032395567,-0.19109947643979,0.6,-0.187808896210873,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.411,-0.147,"7:6","141/150","V:C:I:M:S:T",14.1481370895081,0.901927875940744,114.814237034519,0.123226330243822,82.9586021395589,NA,1.89120602753485,7.2326389241213e-07,6.1407032156959,8.29603358299821,Inf,8.39983046099388e-09,"lineage4","dr_mutations_pyrazinamide","ALA",0,"SRR5818581","SRR5818581","lineage4.2.2","dj","Djibouti","pnca_p.thr160ala","A","E","THR","TA160","pnca_complex.pdb"
|
|
"T160A","L2","PZA","T","T160",160,"A",1,"Pre-XDR","DM","hydrophobic","hydrophobic","neutral","non-polar","polar","non-polar",9.847,-2.509,-0.842,2.1045,-1.519,-0.73,57,75,-0.228,6,6,22,0.127906976744186,"strand",1.63333333333333,4.98,0.0005749604714675,77.8405735976381,1394626.35224664,Inf,33.1802749271012,8,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,0,0,0,0,2,0,4,3,-0.635511651469098,-0.217571059431524,0.0766504709387452,-0.258994032395567,-0.19109947643979,0.6,-0.187808896210873,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.411,-0.147,"7:6","141/150","V:C:I:M:S:T",14.1481370895081,0.901927875940744,114.814237034519,0.123226330243822,82.9586021395589,NA,1.89120602753485,7.2326389241213e-07,6.1407032156959,8.29603358299821,Inf,8.39983046099388e-09,"lineage2","dr_mutations_pyrazinamide","ALA",0,"ERR1873560","ERR1873560","lineage2.2.1","za","South Africa","pnca_p.thr160ala","A","E","THR","TA160","pnca_complex.pdb"
|
|
"T160A","L2","PZA","T","T160",160,"A",1,"XDR","DM","hydrophobic","hydrophobic","neutral","non-polar","polar","non-polar",9.847,-2.509,-0.842,2.1045,-1.519,-0.73,57,75,-0.228,6,6,22,0.127906976744186,"strand",1.63333333333333,4.98,0.0005749604714675,77.8405735976381,1394626.35224664,Inf,33.1802749271012,8,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,0,0,0,0,2,0,4,3,-0.635511651469098,-0.217571059431524,0.0766504709387452,-0.258994032395567,-0.19109947643979,0.6,-0.187808896210873,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.411,-0.147,"7:6","141/150","V:C:I:M:S:T",14.1481370895081,0.901927875940744,114.814237034519,0.123226330243822,82.9586021395589,NA,1.89120602753485,7.2326389241213e-07,6.1407032156959,8.29603358299821,Inf,8.39983046099388e-09,"lineage2","dr_mutations_pyrazinamide","ALA",0,"ERR1873447","ERR1873447","lineage2.2.1","za","South Africa","pnca_p.thr160ala","A","E","THR","TA160","pnca_complex.pdb"
|
|
"T160A","L2","PZA","T","T160",160,"A",1,"XDR","DM","hydrophobic","hydrophobic","neutral","non-polar","polar","non-polar",9.847,-2.509,-0.842,2.1045,-1.519,-0.73,57,75,-0.228,6,6,22,0.127906976744186,"strand",1.63333333333333,4.98,0.0005749604714675,77.8405735976381,1394626.35224664,Inf,33.1802749271012,8,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,0,0,0,0,2,0,4,3,-0.635511651469098,-0.217571059431524,0.0766504709387452,-0.258994032395567,-0.19109947643979,0.6,-0.187808896210873,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.411,-0.147,"7:6","141/150","V:C:I:M:S:T",14.1481370895081,0.901927875940744,114.814237034519,0.123226330243822,82.9586021395589,NA,1.89120602753485,7.2326389241213e-07,6.1407032156959,8.29603358299821,Inf,8.39983046099388e-09,"lineage2","dr_mutations_pyrazinamide","ALA",0,"ERR1873470","ERR1873470","lineage2.2.1","za","South Africa","pnca_p.thr160ala","A","E","THR","TA160","pnca_complex.pdb"
|
|
"T160A","L4","PZA","T","T160",160,"A",NA,"MDR","DM","hydrophobic","hydrophobic","neutral","non-polar","polar","non-polar",9.847,-2.509,-0.842,2.1045,-1.519,-0.73,57,75,-0.228,6,6,22,0.127906976744186,"strand",1.63333333333333,4.98,0.0005749604714675,77.8405735976381,1394626.35224664,Inf,33.1802749271012,8,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,0,0,0,0,2,0,4,3,-0.635511651469098,-0.217571059431524,0.0766504709387452,-0.258994032395567,-0.19109947643979,0.6,-0.187808896210873,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.411,-0.147,"7:6","141/150","V:C:I:M:S:T",14.1481370895081,0.901927875940744,114.814237034519,0.123226330243822,82.9586021395589,NA,1.89120602753485,7.2326389241213e-07,6.1407032156959,8.29603358299821,Inf,8.39983046099388e-09,"lineage4","dr_mutations_pyrazinamide","ALA",0,"SRR5818638","SRR5818638","lineage4.2.2","dj","Djibouti","pnca_p.thr160ala","A","E","THR","TA160","pnca_complex.pdb"
|
|
"T160A","L4","PZA","T","T160",160,"A",NA,"MDR","DM","hydrophobic","hydrophobic","neutral","non-polar","polar","non-polar",9.847,-2.509,-0.842,2.1045,-1.519,-0.73,57,75,-0.228,6,6,22,0.127906976744186,"strand",1.63333333333333,4.98,0.0005749604714675,77.8405735976381,1394626.35224664,Inf,33.1802749271012,8,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,0,0,0,0,2,0,4,3,-0.635511651469098,-0.217571059431524,0.0766504709387452,-0.258994032395567,-0.19109947643979,0.6,-0.187808896210873,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.411,-0.147,"7:6","141/150","V:C:I:M:S:T",14.1481370895081,0.901927875940744,114.814237034519,0.123226330243822,82.9586021395589,NA,1.89120602753485,7.2326389241213e-07,6.1407032156959,8.29603358299821,Inf,8.39983046099388e-09,"lineage4","dr_mutations_pyrazinamide","ALA",0,"ERR1034724","ERR1034724","lineage4.1.2.1","pe","Peru","pnca_p.thr160ala","A","E","THR","TA160","pnca_complex.pdb"
|
|
"T160A","L4","PZA","T","T160",160,"A",NA,"MDR","DM","hydrophobic","hydrophobic","neutral","non-polar","polar","non-polar",9.847,-2.509,-0.842,2.1045,-1.519,-0.73,57,75,-0.228,6,6,22,0.127906976744186,"strand",1.63333333333333,4.98,0.0005749604714675,77.8405735976381,1394626.35224664,Inf,33.1802749271012,8,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,0,0,0,0,2,0,4,3,-0.635511651469098,-0.217571059431524,0.0766504709387452,-0.258994032395567,-0.19109947643979,0.6,-0.187808896210873,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.411,-0.147,"7:6","141/150","V:C:I:M:S:T",14.1481370895081,0.901927875940744,114.814237034519,0.123226330243822,82.9586021395589,NA,1.89120602753485,7.2326389241213e-07,6.1407032156959,8.29603358299821,Inf,8.39983046099388e-09,"lineage4","dr_mutations_pyrazinamide","ALA",0,"BGI_GZ10103,SRR671767","SRR671767","lineage4.5","cn","China","pnca_p.thr160ala","A","E","THR","TA160","pnca_complex.pdb"
|
|
"T160A","L2","PZA","T","T160",160,"A",1,"XDR","DM","hydrophobic","hydrophobic","neutral","non-polar","polar","non-polar",9.847,-2.509,-0.842,2.1045,-1.519,-0.73,57,75,-0.228,6,6,22,0.127906976744186,"strand",1.63333333333333,4.98,0.0005749604714675,77.8405735976381,1394626.35224664,Inf,33.1802749271012,8,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,0,0,0,0,2,0,4,3,-0.635511651469098,-0.217571059431524,0.0766504709387452,-0.258994032395567,-0.19109947643979,0.6,-0.187808896210873,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.411,-0.147,"7:6","141/150","V:C:I:M:S:T",14.1481370895081,0.901927875940744,114.814237034519,0.123226330243822,82.9586021395589,NA,1.89120602753485,7.2326389241213e-07,6.1407032156959,8.29603358299821,Inf,8.39983046099388e-09,"lineage2","dr_mutations_pyrazinamide","ALA",0,"ERR1873562","ERR1873562","lineage2.2.1","za","South Africa","pnca_p.thr160ala","A","E","THR","TA160","pnca_complex.pdb"
|
|
"T160A","L2","PZA","T","T160",160,"A",1,"Pre-XDR","DM","hydrophobic","hydrophobic","neutral","non-polar","polar","non-polar",9.847,-2.509,-0.842,2.1045,-1.519,-0.73,57,75,-0.228,6,6,22,0.127906976744186,"strand",1.63333333333333,4.98,0.0005749604714675,77.8405735976381,1394626.35224664,Inf,33.1802749271012,8,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,0,0,0,0,2,0,4,3,-0.635511651469098,-0.217571059431524,0.0766504709387452,-0.258994032395567,-0.19109947643979,0.6,-0.187808896210873,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.411,-0.147,"7:6","141/150","V:C:I:M:S:T",14.1481370895081,0.901927875940744,114.814237034519,0.123226330243822,82.9586021395589,NA,1.89120602753485,7.2326389241213e-07,6.1407032156959,8.29603358299821,Inf,8.39983046099388e-09,"lineage2","dr_mutations_pyrazinamide","ALA",0,"ERR2515371","ERR2515371","lineage2.2.1","za","South Africa","pnca_p.thr160ala","A","E","THR","TA160","pnca_complex.pdb"
|
|
"T160A","L2","PZA","T","T160",160,"A",1,"XDR","DM","hydrophobic","hydrophobic","neutral","non-polar","polar","non-polar",9.847,-2.509,-0.842,2.1045,-1.519,-0.73,57,75,-0.228,6,6,22,0.127906976744186,"strand",1.63333333333333,4.98,0.0005749604714675,77.8405735976381,1394626.35224664,Inf,33.1802749271012,8,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,0,0,0,0,2,0,4,3,-0.635511651469098,-0.217571059431524,0.0766504709387452,-0.258994032395567,-0.19109947643979,0.6,-0.187808896210873,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.411,-0.147,"7:6","141/150","V:C:I:M:S:T",14.1481370895081,0.901927875940744,114.814237034519,0.123226330243822,82.9586021395589,NA,1.89120602753485,7.2326389241213e-07,6.1407032156959,8.29603358299821,Inf,8.39983046099388e-09,"lineage2","dr_mutations_pyrazinamide","ALA",0,"ERR1873474","ERR1873474","lineage2.2.1","za","South Africa","pnca_p.thr160ala","A","E","THR","TA160","pnca_complex.pdb"
|
|
"T160A","L2","PZA","T","T160",160,"A",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","neutral","non-polar","polar","non-polar",9.847,-2.509,-0.842,2.1045,-1.519,-0.73,57,75,-0.228,6,6,22,0.127906976744186,"strand",1.63333333333333,4.98,0.0005749604714675,77.8405735976381,1394626.35224664,Inf,33.1802749271012,8,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,0,0,0,0,2,0,4,3,-0.635511651469098,-0.217571059431524,0.0766504709387452,-0.258994032395567,-0.19109947643979,0.6,-0.187808896210873,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.411,-0.147,"7:6","141/150","V:C:I:M:S:T",14.1481370895081,0.901927875940744,114.814237034519,0.123226330243822,82.9586021395589,NA,1.89120602753485,7.2326389241213e-07,6.1407032156959,8.29603358299821,Inf,8.39983046099388e-09,"lineage2","dr_mutations_pyrazinamide","ALA",0,"ERR1023465","ERR1023465","lineage2.2.1","","","pnca_p.thr160ala","A","E","THR","TA160","pnca_complex.pdb"
|
|
"T160A","L2","PZA","T","T160",160,"A",1,"XDR","DM","hydrophobic","hydrophobic","neutral","non-polar","polar","non-polar",9.847,-2.509,-0.842,2.1045,-1.519,-0.73,57,75,-0.228,6,6,22,0.127906976744186,"strand",1.63333333333333,4.98,0.0005749604714675,77.8405735976381,1394626.35224664,Inf,33.1802749271012,8,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,0,0,0,0,2,0,4,3,-0.635511651469098,-0.217571059431524,0.0766504709387452,-0.258994032395567,-0.19109947643979,0.6,-0.187808896210873,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.411,-0.147,"7:6","141/150","V:C:I:M:S:T",14.1481370895081,0.901927875940744,114.814237034519,0.123226330243822,82.9586021395589,NA,1.89120602753485,7.2326389241213e-07,6.1407032156959,8.29603358299821,Inf,8.39983046099388e-09,"lineage2","dr_mutations_pyrazinamide","ALA",0,"ERR1873509","ERR1873509","lineage2.2.1","za","South Africa","pnca_p.thr160ala","A","E","THR","TA160","pnca_complex.pdb"
|
|
"T160A","L2","PZA","T","T160",160,"A",NA,"MDR","DM","hydrophobic","hydrophobic","neutral","non-polar","polar","non-polar",9.847,-2.509,-0.842,2.1045,-1.519,-0.73,57,75,-0.228,6,6,22,0.127906976744186,"strand",1.63333333333333,4.98,0.0005749604714675,77.8405735976381,1394626.35224664,Inf,33.1802749271012,8,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,0,0,0,0,2,0,4,3,-0.635511651469098,-0.217571059431524,0.0766504709387452,-0.258994032395567,-0.19109947643979,0.6,-0.187808896210873,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.411,-0.147,"7:6","141/150","V:C:I:M:S:T",14.1481370895081,0.901927875940744,114.814237034519,0.123226330243822,82.9586021395589,NA,1.89120602753485,7.2326389241213e-07,6.1407032156959,8.29603358299821,Inf,8.39983046099388e-09,"lineage2","dr_mutations_pyrazinamide","ALA",0,"SRR5065497","SRR5065497","lineage2.2.1","vn","Vietnam","pnca_p.thr160ala","A","E","THR","TA160","pnca_complex.pdb"
|
|
"T160A","L2;L4","PZA","T","T160",160,"A",NA,"MDR","DM","hydrophobic","hydrophobic","neutral","non-polar","polar","non-polar",9.847,-2.509,-0.842,2.1045,-1.519,-0.73,57,75,-0.228,6,6,22,0.127906976744186,"strand",1.63333333333333,4.98,0.0005749604714675,77.8405735976381,1394626.35224664,Inf,33.1802749271012,8,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,0,0,0,0,2,0,4,3,-0.635511651469098,-0.217571059431524,0.0766504709387452,-0.258994032395567,-0.19109947643979,0.6,-0.187808896210873,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.411,-0.147,"7:6","141/150","V:C:I:M:S:T",14.1481370895081,0.901927875940744,114.814237034519,0.123226330243822,82.9586021395589,NA,1.89120602753485,7.2326389241213e-07,6.1407032156959,8.29603358299821,Inf,8.39983046099388e-09,"lineage2;lineage4","dr_mutations_pyrazinamide","ALA",0,"ERS3466682","ERR3340710","lineage4.1.1.3;lineage2.2.1","za","","pnca_p.thr160ala","A","E","THR","TA160","pnca_complex.pdb"
|
|
"T160P","L2","PZA","T","T160",160,"P",NA,"XDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",9.847,-2.375,-0.79,3.37194,-3.753,-0.23,91,95,-0.228,6,6,22,0.127906976744186,"strand",1.63333333333333,4.98,0.0002156101768003,29.1287878787879,511969.848428359,Inf,9.2872640727157,6,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,-4,2,-6,0,0,0,0,-4,-0.601570415400203,-0.204134366925065,0.122813394619716,-0.639897698209719,-0.0602094240837696,0.957894736842105,-0.187808896210873,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.411,-0.147,"7:6","141/150","V:C:I:M:S:T",13.1460210124992,0.907969111549571,113.719344731883,0.115600569485286,0.183926936278634,NA,1.4643224129316,0.0049931328456149,2.3016268790981,2.00455510251839,Inf,0.0023075254069185,"lineage2","dr_mutations_pyrazinamide","PRO",0,"SRR5710026,SAMN07236538","SRR5710026","lineage2.2.1","th","Thailand","pnca_p.thr160pro","A","E","THR","TA160","pnca_complex.pdb"
|
|
"T160P","L2","PZA","T","T160",160,"P",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",9.847,-2.375,-0.79,3.37194,-3.753,-0.23,91,95,-0.228,6,6,22,0.127906976744186,"strand",1.63333333333333,4.98,0.0002156101768003,29.1287878787879,511969.848428359,Inf,9.2872640727157,6,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,-4,2,-6,0,0,0,0,-4,-0.601570415400203,-0.204134366925065,0.122813394619716,-0.639897698209719,-0.0602094240837696,0.957894736842105,-0.187808896210873,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.411,-0.147,"7:6","141/150","V:C:I:M:S:T",13.1460210124992,0.907969111549571,113.719344731883,0.115600569485286,0.183926936278634,NA,1.4643224129316,0.0049931328456149,2.3016268790981,2.00455510251839,Inf,0.0023075254069185,"lineage2","dr_mutations_pyrazinamide","PRO",0,"SAMN02584642","SRR1168998_SRR1166106","lineage2.2.1","md","Moldova","pnca_p.thr160pro","A","E","THR","TA160","pnca_complex.pdb"
|
|
"T160P","L4","PZA","T","T160",160,"P",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",9.847,-2.375,-0.79,3.37194,-3.753,-0.23,91,95,-0.228,6,6,22,0.127906976744186,"strand",1.63333333333333,4.98,0.0002156101768003,29.1287878787879,511969.848428359,Inf,9.2872640727157,6,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,-4,2,-6,0,0,0,0,-4,-0.601570415400203,-0.204134366925065,0.122813394619716,-0.639897698209719,-0.0602094240837696,0.957894736842105,-0.187808896210873,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.411,-0.147,"7:6","141/150","V:C:I:M:S:T",13.1460210124992,0.907969111549571,113.719344731883,0.115600569485286,0.183926936278634,NA,1.4643224129316,0.0049931328456149,2.3016268790981,2.00455510251839,Inf,0.0023075254069185,"lineage4","dr_mutations_pyrazinamide","PRO",0,"SAMN02584675","SRR1169110_SRR1166177","lineage4.2.1","md","Moldova","pnca_p.thr160pro","A","E","THR","TA160","pnca_complex.pdb"
|
|
"T160P","L2","PZA","T","T160",160,"P",1,"XDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",9.847,-2.375,-0.79,3.37194,-3.753,-0.23,91,95,-0.228,6,6,22,0.127906976744186,"strand",1.63333333333333,4.98,0.0002156101768003,29.1287878787879,511969.848428359,Inf,9.2872640727157,6,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,-4,2,-6,0,0,0,0,-4,-0.601570415400203,-0.204134366925065,0.122813394619716,-0.639897698209719,-0.0602094240837696,0.957894736842105,-0.187808896210873,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.411,-0.147,"7:6","141/150","V:C:I:M:S:T",13.1460210124992,0.907969111549571,113.719344731883,0.115600569485286,0.183926936278634,NA,1.4643224129316,0.0049931328456149,2.3016268790981,2.00455510251839,Inf,0.0023075254069185,"lineage2","dr_mutations_pyrazinamide","PRO",0,"ERR067618,0044Z-sc-2011-09-07T13:19:12Z-1276465","ERR067618","lineage2.2.1","ru","Russia,Samara","pnca_p.thr160pro","A","E","THR","TA160","pnca_complex.pdb"
|
|
"T160P","L4","PZA","T","T160",160,"P",NA,"Pre-MDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",9.847,-2.375,-0.79,3.37194,-3.753,-0.23,91,95,-0.228,6,6,22,0.127906976744186,"strand",1.63333333333333,4.98,0.0002156101768003,29.1287878787879,511969.848428359,Inf,9.2872640727157,6,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,-4,2,-6,0,0,0,0,-4,-0.601570415400203,-0.204134366925065,0.122813394619716,-0.639897698209719,-0.0602094240837696,0.957894736842105,-0.187808896210873,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.411,-0.147,"7:6","141/150","V:C:I:M:S:T",13.1460210124992,0.907969111549571,113.719344731883,0.115600569485286,0.183926936278634,NA,1.4643224129316,0.0049931328456149,2.3016268790981,2.00455510251839,Inf,0.0023075254069185,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR2516756","ERR2516756","lineage4.1.2","gb","UK","pnca_p.thr160pro","A","E","THR","TA160","pnca_complex.pdb"
|
|
"T160P","L2","PZA","T","T160",160,"P",1,"MDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",9.847,-2.375,-0.79,3.37194,-3.753,-0.23,91,95,-0.228,6,6,22,0.127906976744186,"strand",1.63333333333333,4.98,0.0002156101768003,29.1287878787879,511969.848428359,Inf,9.2872640727157,6,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,-4,2,-6,0,0,0,0,-4,-0.601570415400203,-0.204134366925065,0.122813394619716,-0.639897698209719,-0.0602094240837696,0.957894736842105,-0.187808896210873,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.411,-0.147,"7:6","141/150","V:C:I:M:S:T",13.1460210124992,0.907969111549571,113.719344731883,0.115600569485286,0.183926936278634,NA,1.4643224129316,0.0049931328456149,2.3016268790981,2.00455510251839,Inf,0.0023075254069185,"lineage2","dr_mutations_pyrazinamide","PRO",0,"SAMEA2535049,ERS458451","ERR552982_ERR552983","lineage2.2.1","uz","Nukus","pnca_p.thr160pro","A","E","THR","TA160","pnca_complex.pdb"
|
|
"T160P","L2","PZA","T","T160",160,"P",1,"MDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",9.847,-2.375,-0.79,3.37194,-3.753,-0.23,91,95,-0.228,6,6,22,0.127906976744186,"strand",1.63333333333333,4.98,0.0002156101768003,29.1287878787879,511969.848428359,Inf,9.2872640727157,6,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,-4,2,-6,0,0,0,0,-4,-0.601570415400203,-0.204134366925065,0.122813394619716,-0.639897698209719,-0.0602094240837696,0.957894736842105,-0.187808896210873,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.411,-0.147,"7:6","141/150","V:C:I:M:S:T",13.1460210124992,0.907969111549571,113.719344731883,0.115600569485286,0.183926936278634,NA,1.4643224129316,0.0049931328456149,2.3016268790981,2.00455510251839,Inf,0.0023075254069185,"lineage2","dr_mutations_pyrazinamide","PRO",0,"ERR2864290","ERR2864290","lineage2.2.1","pt","Portugal","pnca_p.thr160pro","A","E","THR","TA160","pnca_complex.pdb"
|
|
"T160P","L4","PZA","T","T160",160,"P",NA,"MDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",9.847,-2.375,-0.79,3.37194,-3.753,-0.23,91,95,-0.228,6,6,22,0.127906976744186,"strand",1.63333333333333,4.98,0.0002156101768003,29.1287878787879,511969.848428359,Inf,9.2872640727157,6,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,-4,2,-6,0,0,0,0,-4,-0.601570415400203,-0.204134366925065,0.122813394619716,-0.639897698209719,-0.0602094240837696,0.957894736842105,-0.187808896210873,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.411,-0.147,"7:6","141/150","V:C:I:M:S:T",13.1460210124992,0.907969111549571,113.719344731883,0.115600569485286,0.183926936278634,NA,1.4643224129316,0.0049931328456149,2.3016268790981,2.00455510251839,Inf,0.0023075254069185,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR2707130","ERR2707130","lineage4.3.2","cd","Democratic Republic of Congo","pnca_p.thr160pro","A","E","THR","TA160","pnca_complex.pdb"
|
|
"T160P","L4","PZA","T","T160",160,"P",NA,"MDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",9.847,-2.375,-0.79,3.37194,-3.753,-0.23,91,95,-0.228,6,6,22,0.127906976744186,"strand",1.63333333333333,4.98,0.0002156101768003,29.1287878787879,511969.848428359,Inf,9.2872640727157,6,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,-4,2,-6,0,0,0,0,-4,-0.601570415400203,-0.204134366925065,0.122813394619716,-0.639897698209719,-0.0602094240837696,0.957894736842105,-0.187808896210873,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.411,-0.147,"7:6","141/150","V:C:I:M:S:T",13.1460210124992,0.907969111549571,113.719344731883,0.115600569485286,0.183926936278634,NA,1.4643224129316,0.0049931328456149,2.3016268790981,2.00455510251839,Inf,0.0023075254069185,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR1035353","ERR1035353","lineage4.4.1.2","br","Brazil","pnca_p.thr160pro","A","E","THR","TA160","pnca_complex.pdb"
|
|
"T160P","L2","PZA","T","T160",160,"P",NA,"MDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",9.847,-2.375,-0.79,3.37194,-3.753,-0.23,91,95,-0.228,6,6,22,0.127906976744186,"strand",1.63333333333333,4.98,0.0002156101768003,29.1287878787879,511969.848428359,Inf,9.2872640727157,6,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,-4,2,-6,0,0,0,0,-4,-0.601570415400203,-0.204134366925065,0.122813394619716,-0.639897698209719,-0.0602094240837696,0.957894736842105,-0.187808896210873,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.411,-0.147,"7:6","141/150","V:C:I:M:S:T",13.1460210124992,0.907969111549571,113.719344731883,0.115600569485286,0.183926936278634,NA,1.4643224129316,0.0049931328456149,2.3016268790981,2.00455510251839,Inf,0.0023075254069185,"lineage2","dr_mutations_pyrazinamide","PRO",0,"SAMN02585979","SRR1180315_SRR1181371_SRR1181356_SRR1180396","lineage2.2.1","za","South Africa","pnca_p.thr160pro","A","E","THR","TA160","pnca_complex.pdb"
|
|
"T160P","L4","PZA","T","T160",160,"P",NA,"MDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",9.847,-2.375,-0.79,3.37194,-3.753,-0.23,91,95,-0.228,6,6,22,0.127906976744186,"strand",1.63333333333333,4.98,0.0002156101768003,29.1287878787879,511969.848428359,Inf,9.2872640727157,6,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,-4,2,-6,0,0,0,0,-4,-0.601570415400203,-0.204134366925065,0.122813394619716,-0.639897698209719,-0.0602094240837696,0.957894736842105,-0.187808896210873,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.411,-0.147,"7:6","141/150","V:C:I:M:S:T",13.1460210124992,0.907969111549571,113.719344731883,0.115600569485286,0.183926936278634,NA,1.4643224129316,0.0049931328456149,2.3016268790981,2.00455510251839,Inf,0.0023075254069185,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR2707101","ERR2707101","lineage4.6","cd","Democratic Republic of Congo","pnca_p.thr160pro","A","E","THR","TA160","pnca_complex.pdb"
|
|
"T160P","L4","PZA","T","T160",160,"P",NA,"MDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",9.847,-2.375,-0.79,3.37194,-3.753,-0.23,91,95,-0.228,6,6,22,0.127906976744186,"strand",1.63333333333333,4.98,0.0002156101768003,29.1287878787879,511969.848428359,Inf,9.2872640727157,6,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,-4,2,-6,0,0,0,0,-4,-0.601570415400203,-0.204134366925065,0.122813394619716,-0.639897698209719,-0.0602094240837696,0.957894736842105,-0.187808896210873,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.411,-0.147,"7:6","141/150","V:C:I:M:S:T",13.1460210124992,0.907969111549571,113.719344731883,0.115600569485286,0.183926936278634,NA,1.4643224129316,0.0049931328456149,2.3016268790981,2.00455510251839,Inf,0.0023075254069185,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR1034704","ERR1034704","lineage4.3.2","pe","Peru","pnca_p.thr160pro","A","E","THR","TA160","pnca_complex.pdb"
|
|
"T160P","L4","PZA","T","T160",160,"P",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",9.847,-2.375,-0.79,3.37194,-3.753,-0.23,91,95,-0.228,6,6,22,0.127906976744186,"strand",1.63333333333333,4.98,0.0002156101768003,29.1287878787879,511969.848428359,Inf,9.2872640727157,6,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,-4,2,-6,0,0,0,0,-4,-0.601570415400203,-0.204134366925065,0.122813394619716,-0.639897698209719,-0.0602094240837696,0.957894736842105,-0.187808896210873,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.411,-0.147,"7:6","141/150","V:C:I:M:S:T",13.1460210124992,0.907969111549571,113.719344731883,0.115600569485286,0.183926936278634,NA,1.4643224129316,0.0049931328456149,2.3016268790981,2.00455510251839,Inf,0.0023075254069185,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR1035306","ERR1035306","lineage4.3.3","br","Brazil","pnca_p.thr160pro","A","E","THR","TA160","pnca_complex.pdb"
|
|
"T160P","L2","PZA","T","T160",160,"P",NA,"MDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",9.847,-2.375,-0.79,3.37194,-3.753,-0.23,91,95,-0.228,6,6,22,0.127906976744186,"strand",1.63333333333333,4.98,0.0002156101768003,29.1287878787879,511969.848428359,Inf,9.2872640727157,6,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,-4,2,-6,0,0,0,0,-4,-0.601570415400203,-0.204134366925065,0.122813394619716,-0.639897698209719,-0.0602094240837696,0.957894736842105,-0.187808896210873,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.411,-0.147,"7:6","141/150","V:C:I:M:S:T",13.1460210124992,0.907969111549571,113.719344731883,0.115600569485286,0.183926936278634,NA,1.4643224129316,0.0049931328456149,2.3016268790981,2.00455510251839,Inf,0.0023075254069185,"lineage2","dr_mutations_pyrazinamide","PRO",0,"SAMN02350465","SRR1019140_SRR1140901","lineage2.2.1","za","South Africa","pnca_p.thr160pro","A","E","THR","TA160","pnca_complex.pdb"
|
|
"T160P","L2","PZA","T","T160",160,"P",NA,"MDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",9.847,-2.375,-0.79,3.37194,-3.753,-0.23,91,95,-0.228,6,6,22,0.127906976744186,"strand",1.63333333333333,4.98,0.0002156101768003,29.1287878787879,511969.848428359,Inf,9.2872640727157,6,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,-4,2,-6,0,0,0,0,-4,-0.601570415400203,-0.204134366925065,0.122813394619716,-0.639897698209719,-0.0602094240837696,0.957894736842105,-0.187808896210873,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.411,-0.147,"7:6","141/150","V:C:I:M:S:T",13.1460210124992,0.907969111549571,113.719344731883,0.115600569485286,0.183926936278634,NA,1.4643224129316,0.0049931328456149,2.3016268790981,2.00455510251839,Inf,0.0023075254069185,"lineage2","dr_mutations_pyrazinamide","PRO",0,"SRS797064","SRR1723567","lineage2.2.1","cn","China:Heilongjiang","pnca_p.thr160pro","A","E","THR","TA160","pnca_complex.pdb"
|
|
"T160P","L2","PZA","T","T160",160,"P",NA,"XDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",9.847,-2.375,-0.79,3.37194,-3.753,-0.23,91,95,-0.228,6,6,22,0.127906976744186,"strand",1.63333333333333,4.98,0.0002156101768003,29.1287878787879,511969.848428359,Inf,9.2872640727157,6,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,-4,2,-6,0,0,0,0,-4,-0.601570415400203,-0.204134366925065,0.122813394619716,-0.639897698209719,-0.0602094240837696,0.957894736842105,-0.187808896210873,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.411,-0.147,"7:6","141/150","V:C:I:M:S:T",13.1460210124992,0.907969111549571,113.719344731883,0.115600569485286,0.183926936278634,NA,1.4643224129316,0.0049931328456149,2.3016268790981,2.00455510251839,Inf,0.0023075254069185,"lineage2","dr_mutations_pyrazinamide","PRO",0,"SAMN07236534,SRR5709763","SRR5709763","lineage2.2.1","th","Thailand","pnca_p.thr160pro","A","E","THR","TA160","pnca_complex.pdb"
|
|
"T160R","L4","PZA","T","T160",160,"R",NA,"MDR","DM","hydrophobic","hydrophilic","neutral","basic","polar","pos",9.847,-2.007,-0.456,2.8141,-2.869,-0.29,83,91,-0.228,6,6,22,0.127906976744186,"strand",1.63333333333333,4.98,0.0001437401178668,19.411022297013,511754.463552351,Inf,4.73122070382274,-80,-36,0,-2,-34,0,0,0,0,0,0,-2,0,0,0,0,0,-5,0,-2,-3,-8,0,-2,-4,-0.508358662613982,-0.117829457364341,0.10249564754988,-0.489173060528559,-0.0759162303664921,0.873684210526316,-0.187808896210873,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.411,-0.147,"7:6","141/150","V:C:I:M:S:T",13.14560022562,0.924803768446983,139.277183326532,0.0943844491369454,0.000162837134446,NA,1.28804840845689,0.0292235860951597,1.53426649183163,0.91081598550184,Inf,0.0296198560706035,"lineage4","dr_mutations_pyrazinamide","ARG",0,"SRR4034747","SRR4034747","lineage4.4.1.1","za","South Africa: Kwazulu-Natal","pnca_p.thr160arg","A","E","THR","TA160","pnca_complex.pdb"
|
|
"T160R","L2","PZA","T","T160",160,"R",NA,"MDR","DM","hydrophobic","hydrophilic","neutral","basic","polar","pos",9.847,-2.007,-0.456,2.8141,-2.869,-0.29,83,91,-0.228,6,6,22,0.127906976744186,"strand",1.63333333333333,4.98,0.0001437401178668,19.411022297013,511754.463552351,Inf,4.73122070382274,-80,-36,0,-2,-34,0,0,0,0,0,0,-2,0,0,0,0,0,-5,0,-2,-3,-8,0,-2,-4,-0.508358662613982,-0.117829457364341,0.10249564754988,-0.489173060528559,-0.0759162303664921,0.873684210526316,-0.187808896210873,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.411,-0.147,"7:6","141/150","V:C:I:M:S:T",13.14560022562,0.924803768446983,139.277183326532,0.0943844491369454,0.000162837134446,NA,1.28804840845689,0.0292235860951597,1.53426649183163,0.91081598550184,Inf,0.0296198560706035,"lineage2","dr_mutations_pyrazinamide","ARG",0,"ERR502890","ERR502890","lineage2.2.1","","","pnca_p.thr160arg","A","E","THR","TA160","pnca_complex.pdb"
|
|
"T160R","L4","PZA","T","T160",160,"R",NA,"MDR","DM","hydrophobic","hydrophilic","neutral","basic","polar","pos",9.847,-2.007,-0.456,2.8141,-2.869,-0.29,83,91,-0.228,6,6,22,0.127906976744186,"strand",1.63333333333333,4.98,0.0001437401178668,19.411022297013,511754.463552351,Inf,4.73122070382274,-80,-36,0,-2,-34,0,0,0,0,0,0,-2,0,0,0,0,0,-5,0,-2,-3,-8,0,-2,-4,-0.508358662613982,-0.117829457364341,0.10249564754988,-0.489173060528559,-0.0759162303664921,0.873684210526316,-0.187808896210873,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.411,-0.147,"7:6","141/150","V:C:I:M:S:T",13.14560022562,0.924803768446983,139.277183326532,0.0943844491369454,0.000162837134446,NA,1.28804840845689,0.0292235860951597,1.53426649183163,0.91081598550184,Inf,0.0296198560706035,"lineage4","dr_mutations_pyrazinamide","ARG",0,"SRR4034749","SRR4034749","lineage4.4.1.1","za","South Africa: Kwazulu-Natal","pnca_p.thr160arg","A","E","THR","TA160","pnca_complex.pdb"
|
|
"T160R","L4","PZA","T","T160",160,"R",NA,"MDR","DM","hydrophobic","hydrophilic","neutral","basic","polar","pos",9.847,-2.007,-0.456,2.8141,-2.869,-0.29,83,91,-0.228,6,6,22,0.127906976744186,"strand",1.63333333333333,4.98,0.0001437401178668,19.411022297013,511754.463552351,Inf,4.73122070382274,-80,-36,0,-2,-34,0,0,0,0,0,0,-2,0,0,0,0,0,-5,0,-2,-3,-8,0,-2,-4,-0.508358662613982,-0.117829457364341,0.10249564754988,-0.489173060528559,-0.0759162303664921,0.873684210526316,-0.187808896210873,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.411,-0.147,"7:6","141/150","V:C:I:M:S:T",13.14560022562,0.924803768446983,139.277183326532,0.0943844491369454,0.000162837134446,NA,1.28804840845689,0.0292235860951597,1.53426649183163,0.91081598550184,Inf,0.0296198560706035,"lineage4","dr_mutations_pyrazinamide","ARG",0,"SRR4034755","SRR4034755","lineage4.4.1.1","za","South Africa: Kwazulu-Natal","pnca_p.thr160arg","A","E","THR","TA160","pnca_complex.pdb"
|
|
"T160R","L4","PZA","T","T160",160,"R",NA,"MDR","DM","hydrophobic","hydrophilic","neutral","basic","polar","pos",9.847,-2.007,-0.456,2.8141,-2.869,-0.29,83,91,-0.228,6,6,22,0.127906976744186,"strand",1.63333333333333,4.98,0.0001437401178668,19.411022297013,511754.463552351,Inf,4.73122070382274,-80,-36,0,-2,-34,0,0,0,0,0,0,-2,0,0,0,0,0,-5,0,-2,-3,-8,0,-2,-4,-0.508358662613982,-0.117829457364341,0.10249564754988,-0.489173060528559,-0.0759162303664921,0.873684210526316,-0.187808896210873,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.411,-0.147,"7:6","141/150","V:C:I:M:S:T",13.14560022562,0.924803768446983,139.277183326532,0.0943844491369454,0.000162837134446,NA,1.28804840845689,0.0292235860951597,1.53426649183163,0.91081598550184,Inf,0.0296198560706035,"lineage4","dr_mutations_pyrazinamide","ARG",0,"SRR4034751","SRR4034751","lineage4.4.1.1","za","South Africa: Kwazulu-Natal","pnca_p.thr160arg","A","E","THR","TA160","pnca_complex.pdb"
|
|
"T160R","L4","PZA","T","T160",160,"R",NA,"MDR","DM","hydrophobic","hydrophilic","neutral","basic","polar","pos",9.847,-2.007,-0.456,2.8141,-2.869,-0.29,83,91,-0.228,6,6,22,0.127906976744186,"strand",1.63333333333333,4.98,0.0001437401178668,19.411022297013,511754.463552351,Inf,4.73122070382274,-80,-36,0,-2,-34,0,0,0,0,0,0,-2,0,0,0,0,0,-5,0,-2,-3,-8,0,-2,-4,-0.508358662613982,-0.117829457364341,0.10249564754988,-0.489173060528559,-0.0759162303664921,0.873684210526316,-0.187808896210873,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.411,-0.147,"7:6","141/150","V:C:I:M:S:T",13.14560022562,0.924803768446983,139.277183326532,0.0943844491369454,0.000162837134446,NA,1.28804840845689,0.0292235860951597,1.53426649183163,0.91081598550184,Inf,0.0296198560706035,"lineage4","dr_mutations_pyrazinamide","ARG",0,"SRR4034756","SRR4034756","lineage4.4.1.1","za","South Africa: Kwazulu-Natal","pnca_p.thr160arg","A","E","THR","TA160","pnca_complex.pdb"
|
|
"T160R","L4","PZA","T","T160",160,"R",1,"MDR","DM","hydrophobic","hydrophilic","neutral","basic","polar","pos",9.847,-2.007,-0.456,2.8141,-2.869,-0.29,83,91,-0.228,6,6,22,0.127906976744186,"strand",1.63333333333333,4.98,0.0001437401178668,19.411022297013,511754.463552351,Inf,4.73122070382274,-80,-36,0,-2,-34,0,0,0,0,0,0,-2,0,0,0,0,0,-5,0,-2,-3,-8,0,-2,-4,-0.508358662613982,-0.117829457364341,0.10249564754988,-0.489173060528559,-0.0759162303664921,0.873684210526316,-0.187808896210873,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.411,-0.147,"7:6","141/150","V:C:I:M:S:T",13.14560022562,0.924803768446983,139.277183326532,0.0943844491369454,0.000162837134446,NA,1.28804840845689,0.0292235860951597,1.53426649183163,0.91081598550184,Inf,0.0296198560706035,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERR2515952","ERR2515952","lineage4.4.1.1","za","South Africa","pnca_p.thr160arg","A","E","THR","TA160","pnca_complex.pdb"
|
|
"T160R","L4","PZA","T","T160",160,"R",NA,"MDR","DM","hydrophobic","hydrophilic","neutral","basic","polar","pos",9.847,-2.007,-0.456,2.8141,-2.869,-0.29,83,91,-0.228,6,6,22,0.127906976744186,"strand",1.63333333333333,4.98,0.0001437401178668,19.411022297013,511754.463552351,Inf,4.73122070382274,-80,-36,0,-2,-34,0,0,0,0,0,0,-2,0,0,0,0,0,-5,0,-2,-3,-8,0,-2,-4,-0.508358662613982,-0.117829457364341,0.10249564754988,-0.489173060528559,-0.0759162303664921,0.873684210526316,-0.187808896210873,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.411,-0.147,"7:6","141/150","V:C:I:M:S:T",13.14560022562,0.924803768446983,139.277183326532,0.0943844491369454,0.000162837134446,NA,1.28804840845689,0.0292235860951597,1.53426649183163,0.91081598550184,Inf,0.0296198560706035,"lineage4","dr_mutations_pyrazinamide","ARG",0,"SRR4034753","SRR4034753","lineage4.4.1.1","za","South Africa: Kwazulu-Natal","pnca_p.thr160arg","A","E","THR","TA160","pnca_complex.pdb"
|
|
"T160R","L4","PZA","T","T160",160,"R",NA,"MDR","DM","hydrophobic","hydrophilic","neutral","basic","polar","pos",9.847,-2.007,-0.456,2.8141,-2.869,-0.29,83,91,-0.228,6,6,22,0.127906976744186,"strand",1.63333333333333,4.98,0.0001437401178668,19.411022297013,511754.463552351,Inf,4.73122070382274,-80,-36,0,-2,-34,0,0,0,0,0,0,-2,0,0,0,0,0,-5,0,-2,-3,-8,0,-2,-4,-0.508358662613982,-0.117829457364341,0.10249564754988,-0.489173060528559,-0.0759162303664921,0.873684210526316,-0.187808896210873,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.411,-0.147,"7:6","141/150","V:C:I:M:S:T",13.14560022562,0.924803768446983,139.277183326532,0.0943844491369454,0.000162837134446,NA,1.28804840845689,0.0292235860951597,1.53426649183163,0.91081598550184,Inf,0.0296198560706035,"lineage4","dr_mutations_pyrazinamide","ARG",0,"SRR4034750","SRR4034750","lineage4.4.1.1","za","South Africa: Kwazulu-Natal","pnca_p.thr160arg","A","E","THR","TA160","pnca_complex.pdb"
|
|
"T160R","L4","PZA","T","T160",160,"R",1,"MDR","DM","hydrophobic","hydrophilic","neutral","basic","polar","pos",9.847,-2.007,-0.456,2.8141,-2.869,-0.29,83,91,-0.228,6,6,22,0.127906976744186,"strand",1.63333333333333,4.98,0.0001437401178668,19.411022297013,511754.463552351,Inf,4.73122070382274,-80,-36,0,-2,-34,0,0,0,0,0,0,-2,0,0,0,0,0,-5,0,-2,-3,-8,0,-2,-4,-0.508358662613982,-0.117829457364341,0.10249564754988,-0.489173060528559,-0.0759162303664921,0.873684210526316,-0.187808896210873,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.411,-0.147,"7:6","141/150","V:C:I:M:S:T",13.14560022562,0.924803768446983,139.277183326532,0.0943844491369454,0.000162837134446,NA,1.28804840845689,0.0292235860951597,1.53426649183163,0.91081598550184,Inf,0.0296198560706035,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERR2041765","ERR2041765","lineage4.1.2.1","rs","Serbia","pnca_p.thr160arg","A","E","THR","TA160","pnca_complex.pdb"
|
|
"T160R","L4","PZA","T","T160",160,"R",NA,"MDR","DM","hydrophobic","hydrophilic","neutral","basic","polar","pos",9.847,-2.007,-0.456,2.8141,-2.869,-0.29,83,91,-0.228,6,6,22,0.127906976744186,"strand",1.63333333333333,4.98,0.0001437401178668,19.411022297013,511754.463552351,Inf,4.73122070382274,-80,-36,0,-2,-34,0,0,0,0,0,0,-2,0,0,0,0,0,-5,0,-2,-3,-8,0,-2,-4,-0.508358662613982,-0.117829457364341,0.10249564754988,-0.489173060528559,-0.0759162303664921,0.873684210526316,-0.187808896210873,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.411,-0.147,"7:6","141/150","V:C:I:M:S:T",13.14560022562,0.924803768446983,139.277183326532,0.0943844491369454,0.000162837134446,NA,1.28804840845689,0.0292235860951597,1.53426649183163,0.91081598550184,Inf,0.0296198560706035,"lineage4","dr_mutations_pyrazinamide","ARG",0,"SRR4034752","SRR4034752","lineage4.4.1.1","za","South Africa: Kwazulu-Natal","pnca_p.thr160arg","A","E","THR","TA160","pnca_complex.pdb"
|
|
"T160R","L4","PZA","T","T160",160,"R",NA,"MDR","DM","hydrophobic","hydrophilic","neutral","basic","polar","pos",9.847,-2.007,-0.456,2.8141,-2.869,-0.29,83,91,-0.228,6,6,22,0.127906976744186,"strand",1.63333333333333,4.98,0.0001437401178668,19.411022297013,511754.463552351,Inf,4.73122070382274,-80,-36,0,-2,-34,0,0,0,0,0,0,-2,0,0,0,0,0,-5,0,-2,-3,-8,0,-2,-4,-0.508358662613982,-0.117829457364341,0.10249564754988,-0.489173060528559,-0.0759162303664921,0.873684210526316,-0.187808896210873,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.411,-0.147,"7:6","141/150","V:C:I:M:S:T",13.14560022562,0.924803768446983,139.277183326532,0.0943844491369454,0.000162837134446,NA,1.28804840845689,0.0292235860951597,1.53426649183163,0.91081598550184,Inf,0.0296198560706035,"lineage4","dr_mutations_pyrazinamide","ARG",0,"SRR4034754","SRR4034754","lineage4.4.1.1","za","South Africa: Kwazulu-Natal","pnca_p.thr160arg","A","E","THR","TA160","pnca_complex.pdb"
|
|
"A161G","L2","PZA","A","A161",161,"G",NA,"MDR","OM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",7.033,-0.925,-0.745,2.35053,-1.432,-1.02,50,75,-0.773,8,8,11,0.0852713178294573,"strand",0.233333333333333,4.53,NA,NA,NA,NA,NA,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,2,0,11,10,-0.234295845997974,-0.19250645994832,0.0856114190808499,-0.244160272804774,-0.267015706806283,0.526315789473684,-0.63673805601318,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.872,-0.728,"8:8","141/150","E:Q:V:I:R:K:S:A",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage2","other_mutations_pyrazinamide","GLY",0,"SRS797195","SRR1723714","lineage2.2.1","cn","China:Shanxi","pnca_p.ala161gly","A","E","ALA","AA161","pnca_complex.pdb"
|
|
"A161V","L1","PZA","A","A161",161,"V",NA,"Sensitive","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",7.033,-0.846,0.043,-2.66025,0.125,-0.2,21,63,-0.773,8,8,11,0.0852713178294573,"strand",0.233333333333333,4.53,NA,NA,NA,NA,NA,-2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-5,0,-1,-4,-2,0,-4,-3,-0.214285714285714,0.0365646258503401,-0.511468507267554,0.105574324324324,-0.0523560209424083,0.221052631578947,-0.63673805601318,"Destabilising","Stabilising","Stabilising","Stabilising","Destabilising","effect",-0.872,-0.728,"8:8","141/150","E:Q:V:I:R:K:S:A",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage1","other_mutations_pyrazinamide","VAL",0,"ERR752069","ERR752069","lineage1.1.1","th","Thailand","pnca_p.ala161val","A","E","ALA","AA161","pnca_complex.pdb"
|
|
"G162A","L4","PZA","G","G162",162,"A",NA,"Pre-XDR","OM","hydrophobic","hydrophobic","neutral","non-polar","non-polar","non-polar",8.315,-0.164,-0.551,0.560964,-1.074,-0.09,10,59,-0.02,5,5,26,0.25,"loop",1.86666666666667,3.93,NA,NA,NA,NA,NA,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-4,0,-2,-2,0,0,-1,-12,-0.0415400202634245,-0.142377260981912,0.0204315299499559,-0.183120204603581,-0.0235602094240837,0.105263157894737,-0.0164744645799012,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.244,0.083,"6:5","141/150","F:S:G:A:P",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage4","other_mutations_pyrazinamide","ALA",0,"SAMN02584635","SRR1166166_SRR1169042","lineage4.2.1","md","Moldova","pnca_p.gly162ala","A","-","GLY","GA162","pnca_complex.pdb"
|
|
"G162D","L4","PZA","G","G162",162,"D",1,"MDR","DM","hydrophobic","hydrophilic","neutral","acidic","non-polar","neg",8.315,2.23,-1.037,3.43178,-1.558,-0.94,79,85,-0.02,5,5,26,0.25,"loop",1.86666666666667,3.93,0.0002874802357337,38.8547368421053,1392277.5078503,Inf,13.9909822352959,-20,-24,0,0,-24,0,0,0,0,0,0,0,0,0,0,0,0,-6,0,0,-4,-4,0,-5,-19,1,-0.267958656330749,0.124992897675537,-0.265643648763853,-0.246073298429319,0.831578947368421,-0.0164744645799012,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.244,0.083,"6:5","141/150","F:S:G:A:P",14.146451459095,0.930573112990214,162.371849599053,0.0871237932808364,0.0113995443355929,NA,1.58944397188817,0.0008528275207519,3.06913879340442,3.20302487654751,Inf,0.0001836895199759,"lineage4","dr_mutations_pyrazinamide","ASP",0,"ERR038742","ERR038742","lineage4.8","ug","Uganda","pnca_p.gly162asp","A","-","GLY","GA162","pnca_complex.pdb"
|
|
"G162D","L2","PZA","G","G162",162,"D",1,"MDR","DM","hydrophobic","hydrophilic","neutral","acidic","non-polar","neg",8.315,2.23,-1.037,3.43178,-1.558,-0.94,79,85,-0.02,5,5,26,0.25,"loop",1.86666666666667,3.93,0.0002874802357337,38.8547368421053,1392277.5078503,Inf,13.9909822352959,-20,-24,0,0,-24,0,0,0,0,0,0,0,0,0,0,0,0,-6,0,0,-4,-4,0,-5,-19,1,-0.267958656330749,0.124992897675537,-0.265643648763853,-0.246073298429319,0.831578947368421,-0.0164744645799012,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.244,0.083,"6:5","141/150","F:S:G:A:P",14.146451459095,0.930573112990214,162.371849599053,0.0871237932808364,0.0113995443355929,NA,1.58944397188817,0.0008528275207519,3.06913879340442,3.20302487654751,Inf,0.0001836895199759,"lineage2","dr_mutations_pyrazinamide","ASP",0,"ERR2517548","ERR2517548","lineage2.2.1","nl","Netherlands","pnca_p.gly162asp","A","-","GLY","GA162","pnca_complex.pdb"
|
|
"G162D","L2","PZA","G","G162",162,"D",NA,"MDR","DM","hydrophobic","hydrophilic","neutral","acidic","non-polar","neg",8.315,2.23,-1.037,3.43178,-1.558,-0.94,79,85,-0.02,5,5,26,0.25,"loop",1.86666666666667,3.93,0.0002874802357337,38.8547368421053,1392277.5078503,Inf,13.9909822352959,-20,-24,0,0,-24,0,0,0,0,0,0,0,0,0,0,0,0,-6,0,0,-4,-4,0,-5,-19,1,-0.267958656330749,0.124992897675537,-0.265643648763853,-0.246073298429319,0.831578947368421,-0.0164744645799012,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.244,0.083,"6:5","141/150","F:S:G:A:P",14.146451459095,0.930573112990214,162.371849599053,0.0871237932808364,0.0113995443355929,NA,1.58944397188817,0.0008528275207519,3.06913879340442,3.20302487654751,Inf,0.0001836895199759,"lineage2","dr_mutations_pyrazinamide","ASP",0,"ERR2446459","ERR2446459","lineage2.2.1","nl","Netherlands","pnca_p.gly162asp","A","-","GLY","GA162","pnca_complex.pdb"
|
|
"G162D","L2","PZA","G","G162",162,"D",1,"Pre-XDR","DM","hydrophobic","hydrophilic","neutral","acidic","non-polar","neg",8.315,2.23,-1.037,3.43178,-1.558,-0.94,79,85,-0.02,5,5,26,0.25,"loop",1.86666666666667,3.93,0.0002874802357337,38.8547368421053,1392277.5078503,Inf,13.9909822352959,-20,-24,0,0,-24,0,0,0,0,0,0,0,0,0,0,0,0,-6,0,0,-4,-4,0,-5,-19,1,-0.267958656330749,0.124992897675537,-0.265643648763853,-0.246073298429319,0.831578947368421,-0.0164744645799012,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.244,0.083,"6:5","141/150","F:S:G:A:P",14.146451459095,0.930573112990214,162.371849599053,0.0871237932808364,0.0113995443355929,NA,1.58944397188817,0.0008528275207519,3.06913879340442,3.20302487654751,Inf,0.0001836895199759,"lineage2","dr_mutations_pyrazinamide","ASP",0,"ERR2516230","ERR2516230","lineage2.2.1","be","Belgium","pnca_p.gly162asp","A","-","GLY","GA162","pnca_complex.pdb"
|
|
"G162D","L2","PZA","G","G162",162,"D",NA,"XDR","DM","hydrophobic","hydrophilic","neutral","acidic","non-polar","neg",8.315,2.23,-1.037,3.43178,-1.558,-0.94,79,85,-0.02,5,5,26,0.25,"loop",1.86666666666667,3.93,0.0002874802357337,38.8547368421053,1392277.5078503,Inf,13.9909822352959,-20,-24,0,0,-24,0,0,0,0,0,0,0,0,0,0,0,0,-6,0,0,-4,-4,0,-5,-19,1,-0.267958656330749,0.124992897675537,-0.265643648763853,-0.246073298429319,0.831578947368421,-0.0164744645799012,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.244,0.083,"6:5","141/150","F:S:G:A:P",14.146451459095,0.930573112990214,162.371849599053,0.0871237932808364,0.0113995443355929,NA,1.58944397188817,0.0008528275207519,3.06913879340442,3.20302487654751,Inf,0.0001836895199759,"lineage2","dr_mutations_pyrazinamide","ASP",0,"SRR8237371","SRR8237371","lineage2.2.1","us","","pnca_p.gly162asp","A","-","GLY","GA162","pnca_complex.pdb"
|
|
"G162D","L4","PZA","G","G162",162,"D",1,"MDR","DM","hydrophobic","hydrophilic","neutral","acidic","non-polar","neg",8.315,2.23,-1.037,3.43178,-1.558,-0.94,79,85,-0.02,5,5,26,0.25,"loop",1.86666666666667,3.93,0.0002874802357337,38.8547368421053,1392277.5078503,Inf,13.9909822352959,-20,-24,0,0,-24,0,0,0,0,0,0,0,0,0,0,0,0,-6,0,0,-4,-4,0,-5,-19,1,-0.267958656330749,0.124992897675537,-0.265643648763853,-0.246073298429319,0.831578947368421,-0.0164744645799012,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.244,0.083,"6:5","141/150","F:S:G:A:P",14.146451459095,0.930573112990214,162.371849599053,0.0871237932808364,0.0113995443355929,NA,1.58944397188817,0.0008528275207519,3.06913879340442,3.20302487654751,Inf,0.0001836895199759,"lineage4","dr_mutations_pyrazinamide","ASP",0,"ERS458627,ERR553226,12657-03","ERR553226","lineage4.1","","","pnca_p.gly162asp","A","-","GLY","GA162","pnca_complex.pdb"
|
|
"G162D","L2","PZA","G","G162",162,"D",NA,"MDR","DM","hydrophobic","hydrophilic","neutral","acidic","non-polar","neg",8.315,2.23,-1.037,3.43178,-1.558,-0.94,79,85,-0.02,5,5,26,0.25,"loop",1.86666666666667,3.93,0.0002874802357337,38.8547368421053,1392277.5078503,Inf,13.9909822352959,-20,-24,0,0,-24,0,0,0,0,0,0,0,0,0,0,0,0,-6,0,0,-4,-4,0,-5,-19,1,-0.267958656330749,0.124992897675537,-0.265643648763853,-0.246073298429319,0.831578947368421,-0.0164744645799012,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.244,0.083,"6:5","141/150","F:S:G:A:P",14.146451459095,0.930573112990214,162.371849599053,0.0871237932808364,0.0113995443355929,NA,1.58944397188817,0.0008528275207519,3.06913879340442,3.20302487654751,Inf,0.0001836895199759,"lineage2","dr_mutations_pyrazinamide","ASP",0,"ERR3275447","ERR3275447","lineage2.2.1","nl","Netherlands","pnca_p.gly162asp","A","-","GLY","GA162","pnca_complex.pdb"
|
|
"G162R","L5","PZA","G","G162",162,"R",NA,"Sensitive","OM","hydrophobic","hydrophilic","neutral","basic","non-polar","pos",8.315,-0.04,-0.44,3.42463,-0.961,-0.15,87,91,-0.02,5,5,26,0.25,"loop",1.86666666666667,3.93,NA,NA,NA,NA,NA,-68,-22,0,0,-22,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-3,-5,-2,0,-5,-17,-0.0101317122593718,-0.113695090439276,0.124732479111882,-0.16385336743393,-0.0392670157068062,0.91578947368421,-0.0164744645799012,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.244,0.083,"6:5","141/150","F:S:G:A:P",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage5","other_mutations_pyrazinamide","ARG",0,"ERR702413","ERR702413","lineage5","gh","Ghana","pnca_p.gly162arg","A","-","GLY","GA162","pnca_complex.pdb"
|
|
"G162R","L5","PZA","G","G162",162,"R",NA,"Sensitive","OM","hydrophobic","hydrophilic","neutral","basic","non-polar","pos",8.315,-0.04,-0.44,3.42463,-0.961,-0.15,87,91,-0.02,5,5,26,0.25,"loop",1.86666666666667,3.93,NA,NA,NA,NA,NA,-68,-22,0,0,-22,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-3,-5,-2,0,-5,-17,-0.0101317122593718,-0.113695090439276,0.124732479111882,-0.16385336743393,-0.0392670157068062,0.91578947368421,-0.0164744645799012,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.244,0.083,"6:5","141/150","F:S:G:A:P",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage5","other_mutations_pyrazinamide","ARG",0,"ERR3170403","ERR3170403","lineage5","gh","Ghana","pnca_p.gly162arg","A","-","GLY","GA162","pnca_complex.pdb"
|
|
"G162R","L5","PZA","G","G162",162,"R",NA,"Sensitive","OM","hydrophobic","hydrophilic","neutral","basic","non-polar","pos",8.315,-0.04,-0.44,3.42463,-0.961,-0.15,87,91,-0.02,5,5,26,0.25,"loop",1.86666666666667,3.93,NA,NA,NA,NA,NA,-68,-22,0,0,-22,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-3,-5,-2,0,-5,-17,-0.0101317122593718,-0.113695090439276,0.124732479111882,-0.16385336743393,-0.0392670157068062,0.91578947368421,-0.0164744645799012,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.244,0.083,"6:5","141/150","F:S:G:A:P",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage5","other_mutations_pyrazinamide","ARG",0,"ERR751343","ERR751343","lineage5","gh","Ghana","pnca_p.gly162arg","A","-","GLY","GA162","pnca_complex.pdb"
|
|
"G162R","L5","PZA","G","G162",162,"R",NA,"Sensitive","OM","hydrophobic","hydrophilic","neutral","basic","non-polar","pos",8.315,-0.04,-0.44,3.42463,-0.961,-0.15,87,91,-0.02,5,5,26,0.25,"loop",1.86666666666667,3.93,NA,NA,NA,NA,NA,-68,-22,0,0,-22,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-3,-5,-2,0,-5,-17,-0.0101317122593718,-0.113695090439276,0.124732479111882,-0.16385336743393,-0.0392670157068062,0.91578947368421,-0.0164744645799012,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.244,0.083,"6:5","141/150","F:S:G:A:P",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage5","other_mutations_pyrazinamide","ARG",0,"ERR751322","ERR751322","lineage5","gh","Ghana","pnca_p.gly162arg","A","-","GLY","GA162","pnca_complex.pdb"
|
|
"G162R","L5","PZA","G","G162",162,"R",NA,"Sensitive","OM","hydrophobic","hydrophilic","neutral","basic","non-polar","pos",8.315,-0.04,-0.44,3.42463,-0.961,-0.15,87,91,-0.02,5,5,26,0.25,"loop",1.86666666666667,3.93,NA,NA,NA,NA,NA,-68,-22,0,0,-22,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-3,-5,-2,0,-5,-17,-0.0101317122593718,-0.113695090439276,0.124732479111882,-0.16385336743393,-0.0392670157068062,0.91578947368421,-0.0164744645799012,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.244,0.083,"6:5","141/150","F:S:G:A:P",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage5","other_mutations_pyrazinamide","ARG",0,"ERR751290","ERR751290","lineage5","gh","Ghana","pnca_p.gly162arg","A","-","GLY","GA162","pnca_complex.pdb"
|
|
"G162R","L5","PZA","G","G162",162,"R",NA,"Sensitive","OM","hydrophobic","hydrophilic","neutral","basic","non-polar","pos",8.315,-0.04,-0.44,3.42463,-0.961,-0.15,87,91,-0.02,5,5,26,0.25,"loop",1.86666666666667,3.93,NA,NA,NA,NA,NA,-68,-22,0,0,-22,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-3,-5,-2,0,-5,-17,-0.0101317122593718,-0.113695090439276,0.124732479111882,-0.16385336743393,-0.0392670157068062,0.91578947368421,-0.0164744645799012,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.244,0.083,"6:5","141/150","F:S:G:A:P",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage5","other_mutations_pyrazinamide","ARG",0,"ERR841438","ERR841438","lineage5","gh","Ghana","pnca_p.gly162arg","A","-","GLY","GA162","pnca_complex.pdb"
|
|
"G162S","LBOV","PZA","G","G162",162,"S",NA,"Other","OM","hydrophobic","hydrophilic","neutral","neutral","non-polar","polar",8.315,0.821,-0.866,0.905309,-1.14,-0.55,21,63,-0.02,5,5,26,0.25,"loop",1.86666666666667,3.93,NA,NA,NA,NA,NA,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-6,0,-2,-4,0,0,-3,-13,0.368161434977578,-0.223772609819121,0.0329733243977593,-0.194373401534527,-0.143979057591623,0.221052631578947,-0.0164744645799012,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.244,0.083,"6:5","141/150","F:S:G:A:P",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineageBOV","other_mutations_pyrazinamide","SER",0,"SRR5657412","SRR5657412","lineageBOV","mx","","pnca_p.gly162ser","A","-","GLY","GA162","pnca_complex.pdb"
|
|
"G162S","LBOV","PZA","G","G162",162,"S",NA,"Other","OM","hydrophobic","hydrophilic","neutral","neutral","non-polar","polar",8.315,0.821,-0.866,0.905309,-1.14,-0.55,21,63,-0.02,5,5,26,0.25,"loop",1.86666666666667,3.93,NA,NA,NA,NA,NA,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-6,0,-2,-4,0,0,-3,-13,0.368161434977578,-0.223772609819121,0.0329733243977593,-0.194373401534527,-0.143979057591623,0.221052631578947,-0.0164744645799012,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.244,0.083,"6:5","141/150","F:S:G:A:P",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineageBOV","other_mutations_pyrazinamide","SER",0,"SRR5657431","SRR5657431","lineageBOV","mx","","pnca_p.gly162ser","A","-","GLY","GA162","pnca_complex.pdb"
|
|
"G162S","LBOV","PZA","G","G162",162,"S",NA,"Other","OM","hydrophobic","hydrophilic","neutral","neutral","non-polar","polar",8.315,0.821,-0.866,0.905309,-1.14,-0.55,21,63,-0.02,5,5,26,0.25,"loop",1.86666666666667,3.93,NA,NA,NA,NA,NA,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-6,0,-2,-4,0,0,-3,-13,0.368161434977578,-0.223772609819121,0.0329733243977593,-0.194373401534527,-0.143979057591623,0.221052631578947,-0.0164744645799012,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.244,0.083,"6:5","141/150","F:S:G:A:P",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineageBOV","other_mutations_pyrazinamide","SER",0,"SRR5657421","SRR5657421","lineageBOV","mx","","pnca_p.gly162ser","A","-","GLY","GA162","pnca_complex.pdb"
|
|
"G162S","LBOV","PZA","G","G162",162,"S",NA,"Other","OM","hydrophobic","hydrophilic","neutral","neutral","non-polar","polar",8.315,0.821,-0.866,0.905309,-1.14,-0.55,21,63,-0.02,5,5,26,0.25,"loop",1.86666666666667,3.93,NA,NA,NA,NA,NA,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-6,0,-2,-4,0,0,-3,-13,0.368161434977578,-0.223772609819121,0.0329733243977593,-0.194373401534527,-0.143979057591623,0.221052631578947,-0.0164744645799012,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.244,0.083,"6:5","141/150","F:S:G:A:P",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineageBOV","other_mutations_pyrazinamide","SER",0,"SRR5657454","SRR5657454","lineageBOV","mx","","pnca_p.gly162ser","A","-","GLY","GA162","pnca_complex.pdb"
|
|
"G162S","LBOV","PZA","G","G162",162,"S",NA,"Other","OM","hydrophobic","hydrophilic","neutral","neutral","non-polar","polar",8.315,0.821,-0.866,0.905309,-1.14,-0.55,21,63,-0.02,5,5,26,0.25,"loop",1.86666666666667,3.93,NA,NA,NA,NA,NA,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-6,0,-2,-4,0,0,-3,-13,0.368161434977578,-0.223772609819121,0.0329733243977593,-0.194373401534527,-0.143979057591623,0.221052631578947,-0.0164744645799012,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.244,0.083,"6:5","141/150","F:S:G:A:P",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineageBOV","other_mutations_pyrazinamide","SER",0,"SRR5657406","SRR5657406","lineageBOV","mx","","pnca_p.gly162ser","A","-","GLY","GA162","pnca_complex.pdb"
|
|
"G162S","LBOV","PZA","G","G162",162,"S",NA,"Other","OM","hydrophobic","hydrophilic","neutral","neutral","non-polar","polar",8.315,0.821,-0.866,0.905309,-1.14,-0.55,21,63,-0.02,5,5,26,0.25,"loop",1.86666666666667,3.93,NA,NA,NA,NA,NA,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-6,0,-2,-4,0,0,-3,-13,0.368161434977578,-0.223772609819121,0.0329733243977593,-0.194373401534527,-0.143979057591623,0.221052631578947,-0.0164744645799012,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.244,0.083,"6:5","141/150","F:S:G:A:P",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineageBOV","other_mutations_pyrazinamide","SER",0,"SRR5657371","SRR5657371","lineageBOV","mx","","pnca_p.gly162ser","A","-","GLY","GA162","pnca_complex.pdb"
|
|
"G162S","L4","PZA","G","G162",162,"S",NA,"Sensitive","OM","hydrophobic","hydrophilic","neutral","neutral","non-polar","polar",8.315,0.821,-0.866,0.905309,-1.14,-0.55,21,63,-0.02,5,5,26,0.25,"loop",1.86666666666667,3.93,NA,NA,NA,NA,NA,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-6,0,-2,-4,0,0,-3,-13,0.368161434977578,-0.223772609819121,0.0329733243977593,-0.194373401534527,-0.143979057591623,0.221052631578947,-0.0164744645799012,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.244,0.083,"6:5","141/150","F:S:G:A:P",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage4","other_mutations_pyrazinamide","SER",0,"ERR1213927","ERR1213927","lineage4.3.2","pe","Peru","pnca_p.gly162ser","A","-","GLY","GA162","pnca_complex.pdb"
|
|
"G162S","LBOV","PZA","G","G162",162,"S",NA,"Other","OM","hydrophobic","hydrophilic","neutral","neutral","non-polar","polar",8.315,0.821,-0.866,0.905309,-1.14,-0.55,21,63,-0.02,5,5,26,0.25,"loop",1.86666666666667,3.93,NA,NA,NA,NA,NA,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-6,0,-2,-4,0,0,-3,-13,0.368161434977578,-0.223772609819121,0.0329733243977593,-0.194373401534527,-0.143979057591623,0.221052631578947,-0.0164744645799012,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.244,0.083,"6:5","141/150","F:S:G:A:P",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineageBOV","other_mutations_pyrazinamide","SER",0,"SRR5657460","SRR5657460","lineageBOV","mx","","pnca_p.gly162ser","A","-","GLY","GA162","pnca_complex.pdb"
|
|
"G162S","LBOV","PZA","G","G162",162,"S",NA,"Other","OM","hydrophobic","hydrophilic","neutral","neutral","non-polar","polar",8.315,0.821,-0.866,0.905309,-1.14,-0.55,21,63,-0.02,5,5,26,0.25,"loop",1.86666666666667,3.93,NA,NA,NA,NA,NA,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-6,0,-2,-4,0,0,-3,-13,0.368161434977578,-0.223772609819121,0.0329733243977593,-0.194373401534527,-0.143979057591623,0.221052631578947,-0.0164744645799012,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.244,0.083,"6:5","141/150","F:S:G:A:P",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineageBOV","other_mutations_pyrazinamide","SER",0,"SRR5657472","SRR5657472","lineageBOV","mx","","pnca_p.gly162ser","A","-","GLY","GA162","pnca_complex.pdb"
|
|
"G162S","LBOV","PZA","G","G162",162,"S",NA,"Other","OM","hydrophobic","hydrophilic","neutral","neutral","non-polar","polar",8.315,0.821,-0.866,0.905309,-1.14,-0.55,21,63,-0.02,5,5,26,0.25,"loop",1.86666666666667,3.93,NA,NA,NA,NA,NA,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-6,0,-2,-4,0,0,-3,-13,0.368161434977578,-0.223772609819121,0.0329733243977593,-0.194373401534527,-0.143979057591623,0.221052631578947,-0.0164744645799012,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.244,0.083,"6:5","141/150","F:S:G:A:P",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineageBOV","other_mutations_pyrazinamide","SER",0,"SRR5657508","SRR5657508","lineageBOV","mx","","pnca_p.gly162ser","A","-","GLY","GA162","pnca_complex.pdb"
|
|
"G162S","LBOV","PZA","G","G162",162,"S",NA,"Other","OM","hydrophobic","hydrophilic","neutral","neutral","non-polar","polar",8.315,0.821,-0.866,0.905309,-1.14,-0.55,21,63,-0.02,5,5,26,0.25,"loop",1.86666666666667,3.93,NA,NA,NA,NA,NA,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-6,0,-2,-4,0,0,-3,-13,0.368161434977578,-0.223772609819121,0.0329733243977593,-0.194373401534527,-0.143979057591623,0.221052631578947,-0.0164744645799012,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.244,0.083,"6:5","141/150","F:S:G:A:P",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineageBOV","other_mutations_pyrazinamide","SER",0,"SRR5657374","SRR5657374","lineageBOV","mx","","pnca_p.gly162ser","A","-","GLY","GA162","pnca_complex.pdb"
|
|
"G162S","LBOV","PZA","G","G162",162,"S",NA,"Other","OM","hydrophobic","hydrophilic","neutral","neutral","non-polar","polar",8.315,0.821,-0.866,0.905309,-1.14,-0.55,21,63,-0.02,5,5,26,0.25,"loop",1.86666666666667,3.93,NA,NA,NA,NA,NA,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-6,0,-2,-4,0,0,-3,-13,0.368161434977578,-0.223772609819121,0.0329733243977593,-0.194373401534527,-0.143979057591623,0.221052631578947,-0.0164744645799012,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.244,0.083,"6:5","141/150","F:S:G:A:P",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineageBOV","other_mutations_pyrazinamide","SER",0,"SRR5657496","SRR5657496","lineageBOV","mx","","pnca_p.gly162ser","A","-","GLY","GA162","pnca_complex.pdb"
|
|
"G162S","LBOV","PZA","G","G162",162,"S",NA,"Other","OM","hydrophobic","hydrophilic","neutral","neutral","non-polar","polar",8.315,0.821,-0.866,0.905309,-1.14,-0.55,21,63,-0.02,5,5,26,0.25,"loop",1.86666666666667,3.93,NA,NA,NA,NA,NA,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-6,0,-2,-4,0,0,-3,-13,0.368161434977578,-0.223772609819121,0.0329733243977593,-0.194373401534527,-0.143979057591623,0.221052631578947,-0.0164744645799012,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.244,0.083,"6:5","141/150","F:S:G:A:P",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineageBOV","other_mutations_pyrazinamide","SER",0,"SRR5657502","SRR5657502","lineageBOV","mx","","pnca_p.gly162ser","A","-","GLY","GA162","pnca_complex.pdb"
|
|
"G162S","LBOV","PZA","G","G162",162,"S",NA,"Other","OM","hydrophobic","hydrophilic","neutral","neutral","non-polar","polar",8.315,0.821,-0.866,0.905309,-1.14,-0.55,21,63,-0.02,5,5,26,0.25,"loop",1.86666666666667,3.93,NA,NA,NA,NA,NA,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-6,0,-2,-4,0,0,-3,-13,0.368161434977578,-0.223772609819121,0.0329733243977593,-0.194373401534527,-0.143979057591623,0.221052631578947,-0.0164744645799012,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.244,0.083,"6:5","141/150","F:S:G:A:P",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineageBOV","other_mutations_pyrazinamide","SER",0,"SRR5657423","SRR5657423","lineageBOV","mx","","pnca_p.gly162ser","A","-","GLY","GA162","pnca_complex.pdb"
|
|
"G162S","LBOV","PZA","G","G162",162,"S",NA,"Other","OM","hydrophobic","hydrophilic","neutral","neutral","non-polar","polar",8.315,0.821,-0.866,0.905309,-1.14,-0.55,21,63,-0.02,5,5,26,0.25,"loop",1.86666666666667,3.93,NA,NA,NA,NA,NA,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-6,0,-2,-4,0,0,-3,-13,0.368161434977578,-0.223772609819121,0.0329733243977593,-0.194373401534527,-0.143979057591623,0.221052631578947,-0.0164744645799012,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.244,0.083,"6:5","141/150","F:S:G:A:P",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineageBOV","other_mutations_pyrazinamide","SER",0,"SRR5657523","SRR5657523","lineageBOV","mx","","pnca_p.gly162ser","A","-","GLY","GA162","pnca_complex.pdb"
|
|
"G162S","LBOV","PZA","G","G162",162,"S",NA,"Other","OM","hydrophobic","hydrophilic","neutral","neutral","non-polar","polar",8.315,0.821,-0.866,0.905309,-1.14,-0.55,21,63,-0.02,5,5,26,0.25,"loop",1.86666666666667,3.93,NA,NA,NA,NA,NA,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-6,0,-2,-4,0,0,-3,-13,0.368161434977578,-0.223772609819121,0.0329733243977593,-0.194373401534527,-0.143979057591623,0.221052631578947,-0.0164744645799012,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.244,0.083,"6:5","141/150","F:S:G:A:P",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineageBOV","other_mutations_pyrazinamide","SER",0,"SRR5657426","SRR5657426","lineageBOV","mx","","pnca_p.gly162ser","A","-","GLY","GA162","pnca_complex.pdb"
|
|
"G162S","LBOV","PZA","G","G162",162,"S",NA,"Other","OM","hydrophobic","hydrophilic","neutral","neutral","non-polar","polar",8.315,0.821,-0.866,0.905309,-1.14,-0.55,21,63,-0.02,5,5,26,0.25,"loop",1.86666666666667,3.93,NA,NA,NA,NA,NA,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-6,0,-2,-4,0,0,-3,-13,0.368161434977578,-0.223772609819121,0.0329733243977593,-0.194373401534527,-0.143979057591623,0.221052631578947,-0.0164744645799012,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.244,0.083,"6:5","141/150","F:S:G:A:P",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineageBOV","other_mutations_pyrazinamide","SER",0,"SRR5657373","SRR5657373","lineageBOV","mx","","pnca_p.gly162ser","A","-","GLY","GA162","pnca_complex.pdb"
|
|
"G162S","LBOV","PZA","G","G162",162,"S",NA,"Other","OM","hydrophobic","hydrophilic","neutral","neutral","non-polar","polar",8.315,0.821,-0.866,0.905309,-1.14,-0.55,21,63,-0.02,5,5,26,0.25,"loop",1.86666666666667,3.93,NA,NA,NA,NA,NA,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-6,0,-2,-4,0,0,-3,-13,0.368161434977578,-0.223772609819121,0.0329733243977593,-0.194373401534527,-0.143979057591623,0.221052631578947,-0.0164744645799012,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.244,0.083,"6:5","141/150","F:S:G:A:P",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineageBOV","other_mutations_pyrazinamide","SER",0,"SRR5657389","SRR5657389","lineageBOV","mx","","pnca_p.gly162ser","A","-","GLY","GA162","pnca_complex.pdb"
|
|
"G162S","LBOV","PZA","G","G162",162,"S",NA,"Other","OM","hydrophobic","hydrophilic","neutral","neutral","non-polar","polar",8.315,0.821,-0.866,0.905309,-1.14,-0.55,21,63,-0.02,5,5,26,0.25,"loop",1.86666666666667,3.93,NA,NA,NA,NA,NA,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-6,0,-2,-4,0,0,-3,-13,0.368161434977578,-0.223772609819121,0.0329733243977593,-0.194373401534527,-0.143979057591623,0.221052631578947,-0.0164744645799012,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.244,0.083,"6:5","141/150","F:S:G:A:P",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineageBOV","other_mutations_pyrazinamide","SER",0,"SRR5657492","SRR5657492","lineageBOV","mx","","pnca_p.gly162ser","A","-","GLY","GA162","pnca_complex.pdb"
|
|
"G162S","LBOV","PZA","G","G162",162,"S",NA,"Other","OM","hydrophobic","hydrophilic","neutral","neutral","non-polar","polar",8.315,0.821,-0.866,0.905309,-1.14,-0.55,21,63,-0.02,5,5,26,0.25,"loop",1.86666666666667,3.93,NA,NA,NA,NA,NA,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-6,0,-2,-4,0,0,-3,-13,0.368161434977578,-0.223772609819121,0.0329733243977593,-0.194373401534527,-0.143979057591623,0.221052631578947,-0.0164744645799012,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.244,0.083,"6:5","141/150","F:S:G:A:P",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineageBOV","other_mutations_pyrazinamide","SER",0,"SRR5657453","SRR5657453","lineageBOV","mx","","pnca_p.gly162ser","A","-","GLY","GA162","pnca_complex.pdb"
|
|
"G162S","LBOV","PZA","G","G162",162,"S",NA,"Other","OM","hydrophobic","hydrophilic","neutral","neutral","non-polar","polar",8.315,0.821,-0.866,0.905309,-1.14,-0.55,21,63,-0.02,5,5,26,0.25,"loop",1.86666666666667,3.93,NA,NA,NA,NA,NA,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-6,0,-2,-4,0,0,-3,-13,0.368161434977578,-0.223772609819121,0.0329733243977593,-0.194373401534527,-0.143979057591623,0.221052631578947,-0.0164744645799012,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.244,0.083,"6:5","141/150","F:S:G:A:P",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineageBOV","other_mutations_pyrazinamide","SER",0,"SRR5657411","SRR5657411","lineageBOV","mx","","pnca_p.gly162ser","A","-","GLY","GA162","pnca_complex.pdb"
|
|
"G162S","LBOV","PZA","G","G162",162,"S",NA,"Other","OM","hydrophobic","hydrophilic","neutral","neutral","non-polar","polar",8.315,0.821,-0.866,0.905309,-1.14,-0.55,21,63,-0.02,5,5,26,0.25,"loop",1.86666666666667,3.93,NA,NA,NA,NA,NA,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-6,0,-2,-4,0,0,-3,-13,0.368161434977578,-0.223772609819121,0.0329733243977593,-0.194373401534527,-0.143979057591623,0.221052631578947,-0.0164744645799012,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.244,0.083,"6:5","141/150","F:S:G:A:P",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineageBOV","other_mutations_pyrazinamide","SER",0,"SRR5657522","SRR5657522","lineageBOV","mx","","pnca_p.gly162ser","A","-","GLY","GA162","pnca_complex.pdb"
|
|
"G162S","LBOV","PZA","G","G162",162,"S",NA,"Other","OM","hydrophobic","hydrophilic","neutral","neutral","non-polar","polar",8.315,0.821,-0.866,0.905309,-1.14,-0.55,21,63,-0.02,5,5,26,0.25,"loop",1.86666666666667,3.93,NA,NA,NA,NA,NA,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-6,0,-2,-4,0,0,-3,-13,0.368161434977578,-0.223772609819121,0.0329733243977593,-0.194373401534527,-0.143979057591623,0.221052631578947,-0.0164744645799012,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.244,0.083,"6:5","141/150","F:S:G:A:P",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineageBOV","other_mutations_pyrazinamide","SER",0,"SRR5657450","SRR5657450","lineageBOV","mx","","pnca_p.gly162ser","A","-","GLY","GA162","pnca_complex.pdb"
|
|
"G162S","LBOV","PZA","G","G162",162,"S",NA,"Other","OM","hydrophobic","hydrophilic","neutral","neutral","non-polar","polar",8.315,0.821,-0.866,0.905309,-1.14,-0.55,21,63,-0.02,5,5,26,0.25,"loop",1.86666666666667,3.93,NA,NA,NA,NA,NA,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-6,0,-2,-4,0,0,-3,-13,0.368161434977578,-0.223772609819121,0.0329733243977593,-0.194373401534527,-0.143979057591623,0.221052631578947,-0.0164744645799012,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.244,0.083,"6:5","141/150","F:S:G:A:P",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineageBOV","other_mutations_pyrazinamide","SER",0,"SRR5657467","SRR5657467","lineageBOV","mx","","pnca_p.gly162ser","A","-","GLY","GA162","pnca_complex.pdb"
|
|
"G162S","LBOV","PZA","G","G162",162,"S",NA,"Other","OM","hydrophobic","hydrophilic","neutral","neutral","non-polar","polar",8.315,0.821,-0.866,0.905309,-1.14,-0.55,21,63,-0.02,5,5,26,0.25,"loop",1.86666666666667,3.93,NA,NA,NA,NA,NA,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-6,0,-2,-4,0,0,-3,-13,0.368161434977578,-0.223772609819121,0.0329733243977593,-0.194373401534527,-0.143979057591623,0.221052631578947,-0.0164744645799012,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.244,0.083,"6:5","141/150","F:S:G:A:P",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineageBOV","other_mutations_pyrazinamide","SER",0,"SRR5657503","SRR5657503","lineageBOV","mx","","pnca_p.gly162ser","A","-","GLY","GA162","pnca_complex.pdb"
|
|
"G162S","LBOV","PZA","G","G162",162,"S",NA,"Other","OM","hydrophobic","hydrophilic","neutral","neutral","non-polar","polar",8.315,0.821,-0.866,0.905309,-1.14,-0.55,21,63,-0.02,5,5,26,0.25,"loop",1.86666666666667,3.93,NA,NA,NA,NA,NA,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-6,0,-2,-4,0,0,-3,-13,0.368161434977578,-0.223772609819121,0.0329733243977593,-0.194373401534527,-0.143979057591623,0.221052631578947,-0.0164744645799012,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.244,0.083,"6:5","141/150","F:S:G:A:P",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineageBOV","other_mutations_pyrazinamide","SER",0,"SRR5657370","SRR5657370","lineageBOV","mx","","pnca_p.gly162ser","A","-","GLY","GA162","pnca_complex.pdb"
|
|
"G162S","LBOV","PZA","G","G162",162,"S",NA,"Other","OM","hydrophobic","hydrophilic","neutral","neutral","non-polar","polar",8.315,0.821,-0.866,0.905309,-1.14,-0.55,21,63,-0.02,5,5,26,0.25,"loop",1.86666666666667,3.93,NA,NA,NA,NA,NA,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-6,0,-2,-4,0,0,-3,-13,0.368161434977578,-0.223772609819121,0.0329733243977593,-0.194373401534527,-0.143979057591623,0.221052631578947,-0.0164744645799012,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.244,0.083,"6:5","141/150","F:S:G:A:P",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineageBOV","other_mutations_pyrazinamide","SER",0,"SRR5657414","SRR5657414","lineageBOV","mx","","pnca_p.gly162ser","A","-","GLY","GA162","pnca_complex.pdb"
|
|
"G162S","LBOV","PZA","G","G162",162,"S",NA,"Other","OM","hydrophobic","hydrophilic","neutral","neutral","non-polar","polar",8.315,0.821,-0.866,0.905309,-1.14,-0.55,21,63,-0.02,5,5,26,0.25,"loop",1.86666666666667,3.93,NA,NA,NA,NA,NA,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-6,0,-2,-4,0,0,-3,-13,0.368161434977578,-0.223772609819121,0.0329733243977593,-0.194373401534527,-0.143979057591623,0.221052631578947,-0.0164744645799012,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.244,0.083,"6:5","141/150","F:S:G:A:P",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineageBOV","other_mutations_pyrazinamide","SER",0,"SRR5657415","SRR5657415","lineageBOV","mx","","pnca_p.gly162ser","A","-","GLY","GA162","pnca_complex.pdb"
|
|
"G162S","LBOV","PZA","G","G162",162,"S",NA,"Other","OM","hydrophobic","hydrophilic","neutral","neutral","non-polar","polar",8.315,0.821,-0.866,0.905309,-1.14,-0.55,21,63,-0.02,5,5,26,0.25,"loop",1.86666666666667,3.93,NA,NA,NA,NA,NA,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-6,0,-2,-4,0,0,-3,-13,0.368161434977578,-0.223772609819121,0.0329733243977593,-0.194373401534527,-0.143979057591623,0.221052631578947,-0.0164744645799012,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.244,0.083,"6:5","141/150","F:S:G:A:P",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineageBOV","other_mutations_pyrazinamide","SER",0,"SRR5657519","SRR5657519","lineageBOV","mx","","pnca_p.gly162ser","A","-","GLY","GA162","pnca_complex.pdb"
|
|
"G162S","LBOV","PZA","G","G162",162,"S",NA,"Other","OM","hydrophobic","hydrophilic","neutral","neutral","non-polar","polar",8.315,0.821,-0.866,0.905309,-1.14,-0.55,21,63,-0.02,5,5,26,0.25,"loop",1.86666666666667,3.93,NA,NA,NA,NA,NA,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-6,0,-2,-4,0,0,-3,-13,0.368161434977578,-0.223772609819121,0.0329733243977593,-0.194373401534527,-0.143979057591623,0.221052631578947,-0.0164744645799012,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.244,0.083,"6:5","141/150","F:S:G:A:P",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineageBOV","other_mutations_pyrazinamide","SER",0,"SRR5657507","SRR5657507","lineageBOV","mx","","pnca_p.gly162ser","A","-","GLY","GA162","pnca_complex.pdb"
|
|
"G162S","LBOV","PZA","G","G162",162,"S",NA,"Other","OM","hydrophobic","hydrophilic","neutral","neutral","non-polar","polar",8.315,0.821,-0.866,0.905309,-1.14,-0.55,21,63,-0.02,5,5,26,0.25,"loop",1.86666666666667,3.93,NA,NA,NA,NA,NA,-6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-6,0,-2,-4,0,0,-3,-13,0.368161434977578,-0.223772609819121,0.0329733243977593,-0.194373401534527,-0.143979057591623,0.221052631578947,-0.0164744645799012,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.244,0.083,"6:5","141/150","F:S:G:A:P",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineageBOV","other_mutations_pyrazinamide","SER",0,"SRR5657498","SRR5657498","lineageBOV","mx","","pnca_p.gly162ser","A","-","GLY","GA162","pnca_complex.pdb"
|
|
"G162V","L3","PZA","G","G162",162,"V",NA,"XDR","OM","hydrophobic","hydrophobic","neutral","non-polar","non-polar","non-polar",8.315,-0.162,-0.386,2.07181,-1.467,-1.39,66,80,-0.02,5,5,26,0.25,"loop",1.86666666666667,3.93,NA,NA,NA,NA,NA,-6,-2,0,0,-2,0,0,0,0,6,0,2,2,0,0,0,0,-10,0,-2,-8,4,0,3,-19,-0.0410334346504559,-0.0997416020671834,0.075459829981279,-0.250127877237852,-0.363874345549738,0.694736842105263,-0.0164744645799012,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.244,0.083,"6:5","141/150","F:S:G:A:P",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage3","other_mutations_pyrazinamide","VAL",0,"ERR3335739","ERR3335739","lineage3","pk","Pakistan","pnca_p.gly162val","A","-","GLY","GA162","pnca_complex.pdb"
|
|
"G162V","L3","PZA","G","G162",162,"V",NA,"XDR","OM","hydrophobic","hydrophobic","neutral","non-polar","non-polar","non-polar",8.315,-0.162,-0.386,2.07181,-1.467,-1.39,66,80,-0.02,5,5,26,0.25,"loop",1.86666666666667,3.93,NA,NA,NA,NA,NA,-6,-2,0,0,-2,0,0,0,0,6,0,2,2,0,0,0,0,-10,0,-2,-8,4,0,3,-19,-0.0410334346504559,-0.0997416020671834,0.075459829981279,-0.250127877237852,-0.363874345549738,0.694736842105263,-0.0164744645799012,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.244,0.083,"6:5","141/150","F:S:G:A:P",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage3","other_mutations_pyrazinamide","VAL",0,"ERR3335743","ERR3335743","lineage3","pk","Pakistan","pnca_p.gly162val","A","-","GLY","GA162","pnca_complex.pdb"
|
|
"V163A","L2","PZA","V","V163",163,"A",NA,"MDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",6.663,0.052,-0.478,0.471406,-0.834,-0.36,65,80,-1.017,9,9,87,0.5,"loop",1,4.02,0.0002156101768003,0.807902480033628,4.5966027178937e-05,0,0.000393645565148,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,2,0,6,1,0.0233183856502242,-0.123514211886305,0.0171696326459254,-0.142199488491049,-0.094240837696335,0.684210526315789,-0.837726523887974,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.094,-0.993,"9:9","141/150","V:L:I:M",-9.98760797391822,0.930014323968985,113.719344729607,-0.087826816076596,NA,127.94873509896,-0.0926410587047397,1,0,0,11.7369754738005,0.984170607395186,"lineage2","other_mutations_pyrazinamide","ALA",0,"DRR185076","DRR185076","lineage2.2.1","vn","Vietnam","pnca_p.val163ala","A","S","VAL","VA163","pnca_complex.pdb"
|
|
"V163A","L3","PZA","V","V163",163,"A",0,"Pre-MDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",6.663,0.052,-0.478,0.471406,-0.834,-0.36,65,80,-1.017,9,9,87,0.5,"loop",1,4.02,0.0002156101768003,0.807902480033628,4.5966027178937e-05,0,0.000393645565148,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,2,0,6,1,0.0233183856502242,-0.123514211886305,0.0171696326459254,-0.142199488491049,-0.094240837696335,0.684210526315789,-0.837726523887974,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.094,-0.993,"9:9","141/150","V:L:I:M",-9.98760797391822,0.930014323968985,113.719344729607,-0.087826816076596,NA,127.94873509896,-0.0926410587047397,1,0,0,11.7369754738005,0.984170607395186,"lineage3","other_mutations_pyrazinamide","ALA",0,"ERR2510501","ERR2510501","lineage3","pk","Pakistan","pnca_p.val163ala","A","S","VAL","VA163","pnca_complex.pdb"
|
|
"V163A","L4","PZA","V","V163",163,"A",NA,"MDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",6.663,0.052,-0.478,0.471406,-0.834,-0.36,65,80,-1.017,9,9,87,0.5,"loop",1,4.02,0.0002156101768003,0.807902480033628,4.5966027178937e-05,0,0.000393645565148,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,2,0,6,1,0.0233183856502242,-0.123514211886305,0.0171696326459254,-0.142199488491049,-0.094240837696335,0.684210526315789,-0.837726523887974,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.094,-0.993,"9:9","141/150","V:L:I:M",-9.98760797391822,0.930014323968985,113.719344729607,-0.087826816076596,NA,127.94873509896,-0.0926410587047397,1,0,0,11.7369754738005,0.984170607395186,"lineage4","other_mutations_pyrazinamide","ALA",0,"SAMN02628477","SRR1172713","lineage4.4","ir","Iran","pnca_p.val163ala","A","S","VAL","VA163","pnca_complex.pdb"
|
|
"V163A","L1","PZA","V","V163",163,"A",NA,"MDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",6.663,0.052,-0.478,0.471406,-0.834,-0.36,65,80,-1.017,9,9,87,0.5,"loop",1,4.02,0.0002156101768003,0.807902480033628,4.5966027178937e-05,0,0.000393645565148,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,2,0,6,1,0.0233183856502242,-0.123514211886305,0.0171696326459254,-0.142199488491049,-0.094240837696335,0.684210526315789,-0.837726523887974,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.094,-0.993,"9:9","141/150","V:L:I:M",-9.98760797391822,0.930014323968985,113.719344729607,-0.087826816076596,NA,127.94873509896,-0.0926410587047397,1,0,0,11.7369754738005,0.984170607395186,"lineage1","other_mutations_pyrazinamide","ALA",0,"ERR718287","ERR718287","lineage1.1.1.1","th","Thailand","pnca_p.val163ala","A","S","VAL","VA163","pnca_complex.pdb"
|
|
"V163A","L4","PZA","V","V163",163,"A",NA,"MDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",6.663,0.052,-0.478,0.471406,-0.834,-0.36,65,80,-1.017,9,9,87,0.5,"loop",1,4.02,0.0002156101768003,0.807902480033628,4.5966027178937e-05,0,0.000393645565148,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,2,0,6,1,0.0233183856502242,-0.123514211886305,0.0171696326459254,-0.142199488491049,-0.094240837696335,0.684210526315789,-0.837726523887974,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.094,-0.993,"9:9","141/150","V:L:I:M",-9.98760797391822,0.930014323968985,113.719344729607,-0.087826816076596,NA,127.94873509896,-0.0926410587047397,1,0,0,11.7369754738005,0.984170607395186,"lineage4","other_mutations_pyrazinamide","ALA",0,"ERR1193864","ERR1193864","lineage4.3.3","uz","Uzbekistan","pnca_p.val163ala","A","S","VAL","VA163","pnca_complex.pdb"
|
|
"V163A","L4","PZA","V","V163",163,"A",NA,"MDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",6.663,0.052,-0.478,0.471406,-0.834,-0.36,65,80,-1.017,9,9,87,0.5,"loop",1,4.02,0.0002156101768003,0.807902480033628,4.5966027178937e-05,0,0.000393645565148,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,2,0,6,1,0.0233183856502242,-0.123514211886305,0.0171696326459254,-0.142199488491049,-0.094240837696335,0.684210526315789,-0.837726523887974,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.094,-0.993,"9:9","141/150","V:L:I:M",-9.98760797391822,0.930014323968985,113.719344729607,-0.087826816076596,NA,127.94873509896,-0.0926410587047397,1,0,0,11.7369754738005,0.984170607395186,"lineage4","other_mutations_pyrazinamide","ALA",0,"SRR5709821","SRR5709821","lineage4.4.2","th","Thailand","pnca_p.val163ala","A","S","VAL","VA163","pnca_complex.pdb"
|
|
"V163A","L3","PZA","V","V163",163,"A",0,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",6.663,0.052,-0.478,0.471406,-0.834,-0.36,65,80,-1.017,9,9,87,0.5,"loop",1,4.02,0.0002156101768003,0.807902480033628,4.5966027178937e-05,0,0.000393645565148,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,2,0,6,1,0.0233183856502242,-0.123514211886305,0.0171696326459254,-0.142199488491049,-0.094240837696335,0.684210526315789,-0.837726523887974,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.094,-0.993,"9:9","141/150","V:L:I:M",-9.98760797391822,0.930014323968985,113.719344729607,-0.087826816076596,NA,127.94873509896,-0.0926410587047397,1,0,0,11.7369754738005,0.984170607395186,"lineage3","other_mutations_pyrazinamide","ALA",0,"ERR2510587","ERR2510587","lineage3","pk","Pakistan","pnca_p.val163ala","A","S","VAL","VA163","pnca_complex.pdb"
|
|
"V163A","L4","PZA","V","V163",163,"A",NA,"MDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",6.663,0.052,-0.478,0.471406,-0.834,-0.36,65,80,-1.017,9,9,87,0.5,"loop",1,4.02,0.0002156101768003,0.807902480033628,4.5966027178937e-05,0,0.000393645565148,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,2,0,6,1,0.0233183856502242,-0.123514211886305,0.0171696326459254,-0.142199488491049,-0.094240837696335,0.684210526315789,-0.837726523887974,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.094,-0.993,"9:9","141/150","V:L:I:M",-9.98760797391822,0.930014323968985,113.719344729607,-0.087826816076596,NA,127.94873509896,-0.0926410587047397,1,0,0,11.7369754738005,0.984170607395186,"lineage4","other_mutations_pyrazinamide","ALA",0,"SAMN02231156","SRR998759_SRR998758_SRR998757_SRR998756","lineage4.1","ml","Mali","pnca_p.val163ala","A","S","VAL","VA163","pnca_complex.pdb"
|
|
"V163A","L4","PZA","V","V163",163,"A",NA,"MDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",6.663,0.052,-0.478,0.471406,-0.834,-0.36,65,80,-1.017,9,9,87,0.5,"loop",1,4.02,0.0002156101768003,0.807902480033628,4.5966027178937e-05,0,0.000393645565148,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,2,0,6,1,0.0233183856502242,-0.123514211886305,0.0171696326459254,-0.142199488491049,-0.094240837696335,0.684210526315789,-0.837726523887974,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.094,-0.993,"9:9","141/150","V:L:I:M",-9.98760797391822,0.930014323968985,113.719344729607,-0.087826816076596,NA,127.94873509896,-0.0926410587047397,1,0,0,11.7369754738005,0.984170607395186,"lineage4","other_mutations_pyrazinamide","ALA",0,"SAMN07236417,SRR5709915","SRR5709915","lineage4.4.2","th","Thailand","pnca_p.val163ala","A","S","VAL","VA163","pnca_complex.pdb"
|
|
"V163A","L4","PZA","V","V163",163,"A",0,"MDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",6.663,0.052,-0.478,0.471406,-0.834,-0.36,65,80,-1.017,9,9,87,0.5,"loop",1,4.02,0.0002156101768003,0.807902480033628,4.5966027178937e-05,0,0.000393645565148,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,2,0,6,1,0.0233183856502242,-0.123514211886305,0.0171696326459254,-0.142199488491049,-0.094240837696335,0.684210526315789,-0.837726523887974,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.094,-0.993,"9:9","141/150","V:L:I:M",-9.98760797391822,0.930014323968985,113.719344729607,-0.087826816076596,NA,127.94873509896,-0.0926410587047397,1,0,0,11.7369754738005,0.984170607395186,"lineage4","other_mutations_pyrazinamide","ALA",0,"ERS457767,SAMEA2534365","ERR552032_ERR552033","lineage4.3.3","uz","Nukus","pnca_p.val163ala","A","S","VAL","VA163","pnca_complex.pdb"
|
|
"V163A","L6","PZA","V","V163",163,"A",NA,"MDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",6.663,0.052,-0.478,0.471406,-0.834,-0.36,65,80,-1.017,9,9,87,0.5,"loop",1,4.02,0.0002156101768003,0.807902480033628,4.5966027178937e-05,0,0.000393645565148,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,2,0,6,1,0.0233183856502242,-0.123514211886305,0.0171696326459254,-0.142199488491049,-0.094240837696335,0.684210526315789,-0.837726523887974,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.094,-0.993,"9:9","141/150","V:L:I:M",-9.98760797391822,0.930014323968985,113.719344729607,-0.087826816076596,NA,127.94873509896,-0.0926410587047397,1,0,0,11.7369754738005,0.984170607395186,"lineage6","other_mutations_pyrazinamide","ALA",0,"ERR502506","ERR502506","lineage6","gh","Ghana","pnca_p.val163ala","A","S","VAL","VA163","pnca_complex.pdb"
|
|
"V163A","L2","PZA","V","V163",163,"A",NA,"XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",6.663,0.052,-0.478,0.471406,-0.834,-0.36,65,80,-1.017,9,9,87,0.5,"loop",1,4.02,0.0002156101768003,0.807902480033628,4.5966027178937e-05,0,0.000393645565148,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,2,0,6,1,0.0233183856502242,-0.123514211886305,0.0171696326459254,-0.142199488491049,-0.094240837696335,0.684210526315789,-0.837726523887974,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.094,-0.993,"9:9","141/150","V:L:I:M",-9.98760797391822,0.930014323968985,113.719344729607,-0.087826816076596,NA,127.94873509896,-0.0926410587047397,1,0,0,11.7369754738005,0.984170607395186,"lineage2","other_mutations_pyrazinamide","ALA",0,"ERR502893","ERR502893","lineage2.2.1","","","pnca_p.val163ala","A","S","VAL","VA163","pnca_complex.pdb"
|
|
"V163A","L4","PZA","V","V163",163,"A",NA,"MDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",6.663,0.052,-0.478,0.471406,-0.834,-0.36,65,80,-1.017,9,9,87,0.5,"loop",1,4.02,0.0002156101768003,0.807902480033628,4.5966027178937e-05,0,0.000393645565148,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,2,0,6,1,0.0233183856502242,-0.123514211886305,0.0171696326459254,-0.142199488491049,-0.094240837696335,0.684210526315789,-0.837726523887974,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.094,-0.993,"9:9","141/150","V:L:I:M",-9.98760797391822,0.930014323968985,113.719344729607,-0.087826816076596,NA,127.94873509896,-0.0926410587047397,1,0,0,11.7369754738005,0.984170607395186,"lineage4","other_mutations_pyrazinamide","ALA",0,"SAMN02628478","SRR1174323_SRR1172944","lineage4.4","ir","Iran","pnca_p.val163ala","A","S","VAL","VA163","pnca_complex.pdb"
|
|
"V163G","L3","PZA","V","V163",163,"G",0,"MDR","OM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",6.663,0.031,-0.815,1.14986,-1.019,-0.88,75,85,-1.017,9,9,87,0.5,"loop",1,4.02,0.0001437401178668,1.2119588062211,4.59700131334254e-05,0,1.01056822389159e-25,2,0,0,0,0,0,0,0,0,2,0,0,0,0,0,0,0,0,-1,-1,2,6,0,11,13,0.0139013452914798,-0.210594315245478,0.0418804041404731,-0.173742540494459,-0.230366492146597,0.789473684210526,-0.837726523887974,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.094,-0.993,"9:9","141/150","V:L:I:M",-9.98752126245061,0.942832958100734,139.277183325398,-0.0717096729269461,NA,144471.706314857,0.0834878586628579,1,0,0,25.8386585962163,0.999999999999746,"lineage3","other_mutations_pyrazinamide","GLY",0,"ERR2510439","ERR2510439","lineage3","pk","Pakistan","pnca_p.val163gly","A","S","VAL","VA163","pnca_complex.pdb"
|
|
"V163G","L2","PZA","V","V163",163,"G",0,"MDR","OM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",6.663,0.031,-0.815,1.14986,-1.019,-0.88,75,85,-1.017,9,9,87,0.5,"loop",1,4.02,0.0001437401178668,1.2119588062211,4.59700131334254e-05,0,1.01056822389159e-25,2,0,0,0,0,0,0,0,0,2,0,0,0,0,0,0,0,0,-1,-1,2,6,0,11,13,0.0139013452914798,-0.210594315245478,0.0418804041404731,-0.173742540494459,-0.230366492146597,0.789473684210526,-0.837726523887974,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.094,-0.993,"9:9","141/150","V:L:I:M",-9.98752126245061,0.942832958100734,139.277183325398,-0.0717096729269461,NA,144471.706314857,0.0834878586628579,1,0,0,25.8386585962163,0.999999999999746,"lineage2","other_mutations_pyrazinamide","GLY",0,"ERS457552,SAMEA2534150","ERR551726_ERR551727","lineage2.2.1","uz","Nukus","pnca_p.val163gly","A","S","VAL","VA163","pnca_complex.pdb"
|
|
"V163G","L3","PZA","V","V163",163,"G",NA,"XDR","OM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",6.663,0.031,-0.815,1.14986,-1.019,-0.88,75,85,-1.017,9,9,87,0.5,"loop",1,4.02,0.0001437401178668,1.2119588062211,4.59700131334254e-05,0,1.01056822389159e-25,2,0,0,0,0,0,0,0,0,2,0,0,0,0,0,0,0,0,-1,-1,2,6,0,11,13,0.0139013452914798,-0.210594315245478,0.0418804041404731,-0.173742540494459,-0.230366492146597,0.789473684210526,-0.837726523887974,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-1.094,-0.993,"9:9","141/150","V:L:I:M",-9.98752126245061,0.942832958100734,139.277183325398,-0.0717096729269461,NA,144471.706314857,0.0834878586628579,1,0,0,25.8386585962163,0.999999999999746,"lineage3","other_mutations_pyrazinamide","GLY",0,"SAMN09708356","SRR7585431","lineage3","in","India","pnca_p.val163gly","A","S","VAL","VA163","pnca_complex.pdb"
|
|
"V163L","L4","PZA","V","V163",163,"L",0,"Sensitive","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",6.663,0.072,-0.098,-0.813595,-0.458,-0.37,67,80,-1.017,9,9,87,0.5,"loop",1,4.02,7.18700589334483e-05,2.42412778478352,0.0001249735077034,0,1.03410070803344e-29,-20,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-4,0,0,-4,-6,0,0,-4,0.032286995515695,-0.0253229974160206,-0.156424478966392,-0.0780903665814152,-0.0968586387434555,0.705263157894737,-0.837726523887974,"Stabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-1.094,-0.993,"9:9","141/150","V:L:I:M",-8.98740878149642,0.940032862253634,119.468044435493,-0.0752285585987741,NA,4692673.5108124,0.384555509373631,1,0,0,188.544222231268,0.999999999999997,"lineage4","other_mutations_pyrazinamide","LEU",0,"ERR2515073","ERR2515073","lineage4.1.1.3","gb","UK","pnca_p.val163leu","A","S","VAL","VA163","pnca_complex.pdb"
|
|
"S164P","L4","PZA","S","S164",164,"P",NA,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",10.588,-0.348,-0.304,4.82419,-1.323,-0.03,-23,61,-0.033,5,5,46,0.296774193548387,"loop",1.73333333333333,3.92,0.0004312203536006,58.3312262958281,1393450.9402227,Inf,23.547488635408,0,0,0,0,0,0,0,0,0,4,0,4,0,0,0,0,0,-4,2,-2,-6,-2,0,0,-2,-0.0881458966565349,-0.0785529715762273,0.175707500783077,-0.225575447570332,-0.0078534031413612,-0.247311827956989,-0.0271828665568369,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","neutral",-0.244,0.083,"6:5","140/150","N:V:Q:H:F:E:D:T:G:A:S",14.1472939191292,0.915018435775013,132.576060676288,0.106710773023138,4.17896182047499,NA,1.7659011066874,2.48532104922106e-05,4.60461750194108,5.71767556863798,Inf,1.21868387173808e-06,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR2516576","ERR2516576","lineage4","pe","Peru","pnca_p.ser164pro","A","-","SER","SA164","pnca_complex.pdb"
|
|
"S164P","L2","PZA","S","S164",164,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",10.588,-0.348,-0.304,4.82419,-1.323,-0.03,-23,61,-0.033,5,5,46,0.296774193548387,"loop",1.73333333333333,3.92,0.0004312203536006,58.3312262958281,1393450.9402227,Inf,23.547488635408,0,0,0,0,0,0,0,0,0,4,0,4,0,0,0,0,0,-4,2,-2,-6,-2,0,0,-2,-0.0881458966565349,-0.0785529715762273,0.175707500783077,-0.225575447570332,-0.0078534031413612,-0.247311827956989,-0.0271828665568369,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","neutral",-0.244,0.083,"6:5","140/150","N:V:Q:H:F:E:D:T:G:A:S",14.1472939191292,0.915018435775013,132.576060676288,0.106710773023138,4.17896182047499,NA,1.7659011066874,2.48532104922106e-05,4.60461750194108,5.71767556863798,Inf,1.21868387173808e-06,"lineage2","dr_mutations_pyrazinamide","PRO",0,"ERR1873559","ERR1873559","lineage2.2.1","za","South Africa","pnca_p.ser164pro","A","-","SER","SA164","pnca_complex.pdb"
|
|
"S164P","L4","PZA","S","S164",164,"P",NA,"MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",10.588,-0.348,-0.304,4.82419,-1.323,-0.03,-23,61,-0.033,5,5,46,0.296774193548387,"loop",1.73333333333333,3.92,0.0004312203536006,58.3312262958281,1393450.9402227,Inf,23.547488635408,0,0,0,0,0,0,0,0,0,4,0,4,0,0,0,0,0,-4,2,-2,-6,-2,0,0,-2,-0.0881458966565349,-0.0785529715762273,0.175707500783077,-0.225575447570332,-0.0078534031413612,-0.247311827956989,-0.0271828665568369,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","neutral",-0.244,0.083,"6:5","140/150","N:V:Q:H:F:E:D:T:G:A:S",14.1472939191292,0.915018435775013,132.576060676288,0.106710773023138,4.17896182047499,NA,1.7659011066874,2.48532104922106e-05,4.60461750194108,5.71767556863798,Inf,1.21868387173808e-06,"lineage4","dr_mutations_pyrazinamide","PRO",0,"1245","ERR2432988","lineage4.1.2.1","br","Brazil","pnca_p.ser164pro","A","-","SER","SA164","pnca_complex.pdb"
|
|
"S164P","L2","PZA","S","S164",164,"P",1,"XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",10.588,-0.348,-0.304,4.82419,-1.323,-0.03,-23,61,-0.033,5,5,46,0.296774193548387,"loop",1.73333333333333,3.92,0.0004312203536006,58.3312262958281,1393450.9402227,Inf,23.547488635408,0,0,0,0,0,0,0,0,0,4,0,4,0,0,0,0,0,-4,2,-2,-6,-2,0,0,-2,-0.0881458966565349,-0.0785529715762273,0.175707500783077,-0.225575447570332,-0.0078534031413612,-0.247311827956989,-0.0271828665568369,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","neutral",-0.244,0.083,"6:5","140/150","N:V:Q:H:F:E:D:T:G:A:S",14.1472939191292,0.915018435775013,132.576060676288,0.106710773023138,4.17896182047499,NA,1.7659011066874,2.48532104922106e-05,4.60461750194108,5.71767556863798,Inf,1.21868387173808e-06,"lineage2","dr_mutations_pyrazinamide","PRO",0,"ERR1873558","ERR1873558","lineage2.2.1","za","South Africa","pnca_p.ser164pro","A","-","SER","SA164","pnca_complex.pdb"
|
|
"S164P","L4","PZA","S","S164",164,"P",1,"MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",10.588,-0.348,-0.304,4.82419,-1.323,-0.03,-23,61,-0.033,5,5,46,0.296774193548387,"loop",1.73333333333333,3.92,0.0004312203536006,58.3312262958281,1393450.9402227,Inf,23.547488635408,0,0,0,0,0,0,0,0,0,4,0,4,0,0,0,0,0,-4,2,-2,-6,-2,0,0,-2,-0.0881458966565349,-0.0785529715762273,0.175707500783077,-0.225575447570332,-0.0078534031413612,-0.247311827956989,-0.0271828665568369,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","neutral",-0.244,0.083,"6:5","140/150","N:V:Q:H:F:E:D:T:G:A:S",14.1472939191292,0.915018435775013,132.576060676288,0.106710773023138,4.17896182047499,NA,1.7659011066874,2.48532104922106e-05,4.60461750194108,5.71767556863798,Inf,1.21868387173808e-06,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR2041746","ERR2041746","lineage4.2.2.1","rs","Serbia","pnca_p.ser164pro","A","-","SER","SA164","pnca_complex.pdb"
|
|
"S164P","L3","PZA","S","S164",164,"P",NA,"MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",10.588,-0.348,-0.304,4.82419,-1.323,-0.03,-23,61,-0.033,5,5,46,0.296774193548387,"loop",1.73333333333333,3.92,0.0004312203536006,58.3312262958281,1393450.9402227,Inf,23.547488635408,0,0,0,0,0,0,0,0,0,4,0,4,0,0,0,0,0,-4,2,-2,-6,-2,0,0,-2,-0.0881458966565349,-0.0785529715762273,0.175707500783077,-0.225575447570332,-0.0078534031413612,-0.247311827956989,-0.0271828665568369,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","neutral",-0.244,0.083,"6:5","140/150","N:V:Q:H:F:E:D:T:G:A:S",14.1472939191292,0.915018435775013,132.576060676288,0.106710773023138,4.17896182047499,NA,1.7659011066874,2.48532104922106e-05,4.60461750194108,5.71767556863798,Inf,1.21868387173808e-06,"lineage3","dr_mutations_pyrazinamide","PRO",0,"ERR2245301","ERR2245301","lineage3.1.1","no","","pnca_p.ser164pro","A","-","SER","SA164","pnca_complex.pdb"
|
|
"S164P","L2","PZA","S","S164",164,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",10.588,-0.348,-0.304,4.82419,-1.323,-0.03,-23,61,-0.033,5,5,46,0.296774193548387,"loop",1.73333333333333,3.92,0.0004312203536006,58.3312262958281,1393450.9402227,Inf,23.547488635408,0,0,0,0,0,0,0,0,0,4,0,4,0,0,0,0,0,-4,2,-2,-6,-2,0,0,-2,-0.0881458966565349,-0.0785529715762273,0.175707500783077,-0.225575447570332,-0.0078534031413612,-0.247311827956989,-0.0271828665568369,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","neutral",-0.244,0.083,"6:5","140/150","N:V:Q:H:F:E:D:T:G:A:S",14.1472939191292,0.915018435775013,132.576060676288,0.106710773023138,4.17896182047499,NA,1.7659011066874,2.48532104922106e-05,4.60461750194108,5.71767556863798,Inf,1.21868387173808e-06,"lineage2","dr_mutations_pyrazinamide","PRO",0,"ERR1873450","ERR1873450","lineage2.2.1","za","South Africa","pnca_p.ser164pro","A","-","SER","SA164","pnca_complex.pdb"
|
|
"S164P","L3","PZA","S","S164",164,"P",1,"MDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",10.588,-0.348,-0.304,4.82419,-1.323,-0.03,-23,61,-0.033,5,5,46,0.296774193548387,"loop",1.73333333333333,3.92,0.0004312203536006,58.3312262958281,1393450.9402227,Inf,23.547488635408,0,0,0,0,0,0,0,0,0,4,0,4,0,0,0,0,0,-4,2,-2,-6,-2,0,0,-2,-0.0881458966565349,-0.0785529715762273,0.175707500783077,-0.225575447570332,-0.0078534031413612,-0.247311827956989,-0.0271828665568369,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","neutral",-0.244,0.083,"6:5","140/150","N:V:Q:H:F:E:D:T:G:A:S",14.1472939191292,0.915018435775013,132.576060676288,0.106710773023138,4.17896182047499,NA,1.7659011066874,2.48532104922106e-05,4.60461750194108,5.71767556863798,Inf,1.21868387173808e-06,"lineage3","dr_mutations_pyrazinamide","PRO",0,"ERR3335767","ERR3335767","lineage3","pk","Pakistan","pnca_p.ser164pro","A","-","SER","SA164","pnca_complex.pdb"
|
|
"S164P","L2","PZA","S","S164",164,"P",NA,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",10.588,-0.348,-0.304,4.82419,-1.323,-0.03,-23,61,-0.033,5,5,46,0.296774193548387,"loop",1.73333333333333,3.92,0.0004312203536006,58.3312262958281,1393450.9402227,Inf,23.547488635408,0,0,0,0,0,0,0,0,0,4,0,4,0,0,0,0,0,-4,2,-2,-6,-2,0,0,-2,-0.0881458966565349,-0.0785529715762273,0.175707500783077,-0.225575447570332,-0.0078534031413612,-0.247311827956989,-0.0271828665568369,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","neutral",-0.244,0.083,"6:5","140/150","N:V:Q:H:F:E:D:T:G:A:S",14.1472939191292,0.915018435775013,132.576060676288,0.106710773023138,4.17896182047499,NA,1.7659011066874,2.48532104922106e-05,4.60461750194108,5.71767556863798,Inf,1.21868387173808e-06,"lineage2","dr_mutations_pyrazinamide","PRO",0,"ERR2515322","ERR2515322","lineage2.2.1","za","South Africa","pnca_p.ser164pro","A","-","SER","SA164","pnca_complex.pdb"
|
|
"S164P","L2","PZA","S","S164",164,"P",1,"Pre-XDR","DM","hydrophilic","hydrophilic","neutral","non-polar","polar","non-polar",10.588,-0.348,-0.304,4.82419,-1.323,-0.03,-23,61,-0.033,5,5,46,0.296774193548387,"loop",1.73333333333333,3.92,0.0004312203536006,58.3312262958281,1393450.9402227,Inf,23.547488635408,0,0,0,0,0,0,0,0,0,4,0,4,0,0,0,0,0,-4,2,-2,-6,-2,0,0,-2,-0.0881458966565349,-0.0785529715762273,0.175707500783077,-0.225575447570332,-0.0078534031413612,-0.247311827956989,-0.0271828665568369,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","neutral",-0.244,0.083,"6:5","140/150","N:V:Q:H:F:E:D:T:G:A:S",14.1472939191292,0.915018435775013,132.576060676288,0.106710773023138,4.17896182047499,NA,1.7659011066874,2.48532104922106e-05,4.60461750194108,5.71767556863798,Inf,1.21868387173808e-06,"lineage2","dr_mutations_pyrazinamide","PRO",0,"ERS2592786","ERR2677440","lineage2.2.1","de","Germany","pnca_p.ser164pro","A","-","SER","SA164","pnca_complex.pdb"
|
|
"T167I","L2","PZA","T","T167",167,"I",1,"Pre-XDR","OM","hydrophobic","hydrophobic","neutral","non-polar","polar","non-polar",10.663,-0.489,0.627,0.429573,-0.058,-0.04,19,59,0.303,4,4,57,0.331395348837209,"helix",-1.63333333333333,4.06,0.0001437401178668,4.85029436501262,4.85029432717736,4.84956447904112,0.0881192621863332,-6,0,0,0,0,0,0,0,0,2,0,0,2,0,0,0,0,-3,0,1,-2,0,0,0,-2,-0.123860182370821,0.533163265306122,0.0156459837265714,-0.00988917306052856,-0.0104712041884816,0.2,0.0971153846153846,"Destabilising","Stabilising","Destabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","129/150","L:N:R:E:Q:D:G:A:S:T:P",1.57903938912402,0.264247566376722,1.41439286276584,1.11640791656443,0.191756076673841,122.683760399237,0.685768096792206,0.312734154310187,0.504824686014995,0.061763864579114,379.558337204203,0.766581879696361,"lineage2","other_mutations_pyrazinamide","ILE",0,"ERS458430,SAMEA2535028","ERR552955_ERR552956","lineage2.2.1","uz","Nukus","pnca_p.thr167ile","A","H","THR","TA167","pnca_complex.pdb"
|
|
"T167I","L4","PZA","T","T167",167,"I",NA,"MDR","OM","hydrophobic","hydrophobic","neutral","non-polar","polar","non-polar",10.663,-0.489,0.627,0.429573,-0.058,-0.04,19,59,0.303,4,4,57,0.331395348837209,"helix",-1.63333333333333,4.06,0.0001437401178668,4.85029436501262,4.85029432717736,4.84956447904112,0.0881192621863332,-6,0,0,0,0,0,0,0,0,2,0,0,2,0,0,0,0,-3,0,1,-2,0,0,0,-2,-0.123860182370821,0.533163265306122,0.0156459837265714,-0.00988917306052856,-0.0104712041884816,0.2,0.0971153846153846,"Destabilising","Stabilising","Destabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","129/150","L:N:R:E:Q:D:G:A:S:T:P",1.57903938912402,0.264247566376722,1.41439286276584,1.11640791656443,0.191756076673841,122.683760399237,0.685768096792206,0.312734154310187,0.504824686014995,0.061763864579114,379.558337204203,0.766581879696361,"lineage4","other_mutations_pyrazinamide","ILE",0,"ERR2706934","ERR2706934","lineage4.3.2","cd","Democratic Republic of Congo","pnca_p.thr167ile","A","H","THR","TA167","pnca_complex.pdb"
|
|
"T167I","L2","PZA","T","T167",167,"I",NA,"Pre-XDR","OM","hydrophobic","hydrophobic","neutral","non-polar","polar","non-polar",10.663,-0.489,0.627,0.429573,-0.058,-0.04,19,59,0.303,4,4,57,0.331395348837209,"helix",-1.63333333333333,4.06,0.0001437401178668,4.85029436501262,4.85029432717736,4.84956447904112,0.0881192621863332,-6,0,0,0,0,0,0,0,0,2,0,0,2,0,0,0,0,-3,0,1,-2,0,0,0,-2,-0.123860182370821,0.533163265306122,0.0156459837265714,-0.00988917306052856,-0.0104712041884816,0.2,0.0971153846153846,"Destabilising","Stabilising","Destabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","129/150","L:N:R:E:Q:D:G:A:S:T:P",1.57903938912402,0.264247566376722,1.41439286276584,1.11640791656443,0.191756076673841,122.683760399237,0.685768096792206,0.312734154310187,0.504824686014995,0.061763864579114,379.558337204203,0.766581879696361,"lineage2","other_mutations_pyrazinamide","ILE",0,"SRR7341676","SRR7341676","lineage2.2.1","ro","Romania","pnca_p.thr167ile","A","H","THR","TA167","pnca_complex.pdb"
|
|
"T167I","L3","PZA","T","T167",167,"I",NA,"XDR","OM","hydrophobic","hydrophobic","neutral","non-polar","polar","non-polar",10.663,-0.489,0.627,0.429573,-0.058,-0.04,19,59,0.303,4,4,57,0.331395348837209,"helix",-1.63333333333333,4.06,0.0001437401178668,4.85029436501262,4.85029432717736,4.84956447904112,0.0881192621863332,-6,0,0,0,0,0,0,0,0,2,0,0,2,0,0,0,0,-3,0,1,-2,0,0,0,-2,-0.123860182370821,0.533163265306122,0.0156459837265714,-0.00988917306052856,-0.0104712041884816,0.2,0.0971153846153846,"Destabilising","Stabilising","Destabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","129/150","L:N:R:E:Q:D:G:A:S:T:P",1.57903938912402,0.264247566376722,1.41439286276584,1.11640791656443,0.191756076673841,122.683760399237,0.685768096792206,0.312734154310187,0.504824686014995,0.061763864579114,379.558337204203,0.766581879696361,"lineage3","other_mutations_pyrazinamide","ILE",0,"SRR7898219","SRR7898219","lineage3.1.2","in","India","pnca_p.thr167ile","A","H","THR","TA167","pnca_complex.pdb"
|
|
"T167I","L5","PZA","T","T167",167,"I",NA,"MDR","OM","hydrophobic","hydrophobic","neutral","non-polar","polar","non-polar",10.663,-0.489,0.627,0.429573,-0.058,-0.04,19,59,0.303,4,4,57,0.331395348837209,"helix",-1.63333333333333,4.06,0.0001437401178668,4.85029436501262,4.85029432717736,4.84956447904112,0.0881192621863332,-6,0,0,0,0,0,0,0,0,2,0,0,2,0,0,0,0,-3,0,1,-2,0,0,0,-2,-0.123860182370821,0.533163265306122,0.0156459837265714,-0.00988917306052856,-0.0104712041884816,0.2,0.0971153846153846,"Destabilising","Stabilising","Destabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","129/150","L:N:R:E:Q:D:G:A:S:T:P",1.57903938912402,0.264247566376722,1.41439286276584,1.11640791656443,0.191756076673841,122.683760399237,0.685768096792206,0.312734154310187,0.504824686014995,0.061763864579114,379.558337204203,0.766581879696361,"lineage5","other_mutations_pyrazinamide","ILE",0,"ERR3170471","ERR3170471","lineage5","gh","Ghana","pnca_p.thr167ile","A","H","THR","TA167","pnca_complex.pdb"
|
|
"T167I","L4","PZA","T","T167",167,"I",0,"MDR","OM","hydrophobic","hydrophobic","neutral","non-polar","polar","non-polar",10.663,-0.489,0.627,0.429573,-0.058,-0.04,19,59,0.303,4,4,57,0.331395348837209,"helix",-1.63333333333333,4.06,0.0001437401178668,4.85029436501262,4.85029432717736,4.84956447904112,0.0881192621863332,-6,0,0,0,0,0,0,0,0,2,0,0,2,0,0,0,0,-3,0,1,-2,0,0,0,-2,-0.123860182370821,0.533163265306122,0.0156459837265714,-0.00988917306052856,-0.0104712041884816,0.2,0.0971153846153846,"Destabilising","Stabilising","Destabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","129/150","L:N:R:E:Q:D:G:A:S:T:P",1.57903938912402,0.264247566376722,1.41439286276584,1.11640791656443,0.191756076673841,122.683760399237,0.685768096792206,0.312734154310187,0.504824686014995,0.061763864579114,379.558337204203,0.766581879696361,"lineage4","other_mutations_pyrazinamide","ILE",0,"ERR2515801","ERR2515801","lineage4.3.4.2","za","South Africa","pnca_p.thr167ile","A","H","THR","TA167","pnca_complex.pdb"
|
|
"T167I","L2","PZA","T","T167",167,"I",NA,"Pre-MDR","OM","hydrophobic","hydrophobic","neutral","non-polar","polar","non-polar",10.663,-0.489,0.627,0.429573,-0.058,-0.04,19,59,0.303,4,4,57,0.331395348837209,"helix",-1.63333333333333,4.06,0.0001437401178668,4.85029436501262,4.85029432717736,4.84956447904112,0.0881192621863332,-6,0,0,0,0,0,0,0,0,2,0,0,2,0,0,0,0,-3,0,1,-2,0,0,0,-2,-0.123860182370821,0.533163265306122,0.0156459837265714,-0.00988917306052856,-0.0104712041884816,0.2,0.0971153846153846,"Destabilising","Stabilising","Destabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","129/150","L:N:R:E:Q:D:G:A:S:T:P",1.57903938912402,0.264247566376722,1.41439286276584,1.11640791656443,0.191756076673841,122.683760399237,0.685768096792206,0.312734154310187,0.504824686014995,0.061763864579114,379.558337204203,0.766581879696361,"lineage2","other_mutations_pyrazinamide","ILE",0,"SRR5709750,SAMN07236304","SRR5709750","lineage2.2.1","th","Thailand","pnca_p.thr167ile","A","H","THR","TA167","pnca_complex.pdb"
|
|
"T168I","L1","PZA","T","T168",168,"I",NA,"Sensitive","OM","hydrophobic","hydrophobic","neutral","non-polar","polar","non-polar",10.468,-1.201,0.963,-0.7812,-0.018,0.69,11,59,0.703,2,2,24,0.13953488372093,"helix",0.933333333333333,4.77,0.0002874802357337,0.605874316939891,1.69083297052993e-05,0,0.0596751347828363,-12,0,0,0,0,0,0,0,0,2,0,0,2,0,0,0,0,-3,0,-3,-2,0,0,0,0,-0.304204660587639,0.818877551020408,-0.150196108590325,-0.0030690537084399,0.387640449438202,0.115789473684211,0.225320512820513,"Destabilising","Stabilising","Stabilising","Destabilising","Stabilising","effect",0.389,0.842,"4:2","124/150","L:N:V:C:R:Y:H:F:W:G:S:A:T:P",-10.9877041754913,0.946048325624975,162.371849597271,-0.0676700068561389,NA,2065.08997177458,-0.217617456890647,1,0,0,7.34660540805975,0.807010141806273,"lineage1","other_mutations_pyrazinamide","ILE",0,"ERR768038","ERR768038","lineage1.1","th","Thailand","pnca_p.thr168ile","A","H","THR","TA168","pnca_complex.pdb"
|
|
"T168I","L4","PZA","T","T168",168,"I",0,"Sensitive","OM","hydrophobic","hydrophobic","neutral","non-polar","polar","non-polar",10.468,-1.201,0.963,-0.7812,-0.018,0.69,11,59,0.703,2,2,24,0.13953488372093,"helix",0.933333333333333,4.77,0.0002874802357337,0.605874316939891,1.69083297052993e-05,0,0.0596751347828363,-12,0,0,0,0,0,0,0,0,2,0,0,2,0,0,0,0,-3,0,-3,-2,0,0,0,0,-0.304204660587639,0.818877551020408,-0.150196108590325,-0.0030690537084399,0.387640449438202,0.115789473684211,0.225320512820513,"Destabilising","Stabilising","Stabilising","Destabilising","Stabilising","effect",0.389,0.842,"4:2","124/150","L:N:V:C:R:Y:H:F:W:G:S:A:T:P",-10.9877041754913,0.946048325624975,162.371849597271,-0.0676700068561389,NA,2065.08997177458,-0.217617456890647,1,0,0,7.34660540805975,0.807010141806273,"lineage4","other_mutations_pyrazinamide","ILE",0,"2636R-sc-2012-10-11T13:41:11Z-1494375,ERR234697","ERR234697","lineage4.2.1","ru","Russia","pnca_p.thr168ile","A","H","THR","TA168","pnca_complex.pdb"
|
|
"T168I","L4","PZA","T","T168",168,"I",0,"Sensitive","OM","hydrophobic","hydrophobic","neutral","non-polar","polar","non-polar",10.468,-1.201,0.963,-0.7812,-0.018,0.69,11,59,0.703,2,2,24,0.13953488372093,"helix",0.933333333333333,4.77,0.0002874802357337,0.605874316939891,1.69083297052993e-05,0,0.0596751347828363,-12,0,0,0,0,0,0,0,0,2,0,0,2,0,0,0,0,-3,0,-3,-2,0,0,0,0,-0.304204660587639,0.818877551020408,-0.150196108590325,-0.0030690537084399,0.387640449438202,0.115789473684211,0.225320512820513,"Destabilising","Stabilising","Stabilising","Destabilising","Stabilising","effect",0.389,0.842,"4:2","124/150","L:N:V:C:R:Y:H:F:W:G:S:A:T:P",-10.9877041754913,0.946048325624975,162.371849597271,-0.0676700068561389,NA,2065.08997177458,-0.217617456890647,1,0,0,7.34660540805975,0.807010141806273,"lineage4","other_mutations_pyrazinamide","ILE",0,"2433W-sc-2012-10-11T13:39:23Z-1494262,ERR229943","ERR229943","lineage4.3.3","ru","Russia","pnca_p.thr168ile","A","H","THR","TA168","pnca_complex.pdb"
|
|
"T168I","L4","PZA","T","T168",168,"I",0,"Pre-XDR","OM","hydrophobic","hydrophobic","neutral","non-polar","polar","non-polar",10.468,-1.201,0.963,-0.7812,-0.018,0.69,11,59,0.703,2,2,24,0.13953488372093,"helix",0.933333333333333,4.77,0.0002874802357337,0.605874316939891,1.69083297052993e-05,0,0.0596751347828363,-12,0,0,0,0,0,0,0,0,2,0,0,2,0,0,0,0,-3,0,-3,-2,0,0,0,0,-0.304204660587639,0.818877551020408,-0.150196108590325,-0.0030690537084399,0.387640449438202,0.115789473684211,0.225320512820513,"Destabilising","Stabilising","Stabilising","Destabilising","Stabilising","effect",0.389,0.842,"4:2","124/150","L:N:V:C:R:Y:H:F:W:G:S:A:T:P",-10.9877041754913,0.946048325624975,162.371849597271,-0.0676700068561389,NA,2065.08997177458,-0.217617456890647,1,0,0,7.34660540805975,0.807010141806273,"lineage4","other_mutations_pyrazinamide","ILE",0,"ERS456792","ERR550685_ERR550684","lineage4.2.1","uz","Nukus","pnca_p.thr168ile","A","H","THR","TA168","pnca_complex.pdb"
|
|
"T168I","L4","PZA","T","T168",168,"I",0,"Pre-XDR","OM","hydrophobic","hydrophobic","neutral","non-polar","polar","non-polar",10.468,-1.201,0.963,-0.7812,-0.018,0.69,11,59,0.703,2,2,24,0.13953488372093,"helix",0.933333333333333,4.77,0.0002874802357337,0.605874316939891,1.69083297052993e-05,0,0.0596751347828363,-12,0,0,0,0,0,0,0,0,2,0,0,2,0,0,0,0,-3,0,-3,-2,0,0,0,0,-0.304204660587639,0.818877551020408,-0.150196108590325,-0.0030690537084399,0.387640449438202,0.115789473684211,0.225320512820513,"Destabilising","Stabilising","Stabilising","Destabilising","Stabilising","effect",0.389,0.842,"4:2","124/150","L:N:V:C:R:Y:H:F:W:G:S:A:T:P",-10.9877041754913,0.946048325624975,162.371849597271,-0.0676700068561389,NA,2065.08997177458,-0.217617456890647,1,0,0,7.34660540805975,0.807010141806273,"lineage4","other_mutations_pyrazinamide","ILE",0,"ERS457710,SAMEA2534308","ERR551948_ERR551949","lineage4.2.1","uz","Nukus","pnca_p.thr168ile","A","H","THR","TA168","pnca_complex.pdb"
|
|
"T168N","L4","PZA","T","T168",168,"N",NA,"MDR","DM","hydrophobic","hydrophilic","neutral","neutral","polar","polar",10.468,-0.341,-0.505,0.148032,-1.149,-0.45,3,53,0.703,2,2,24,0.13953488372093,"helix",0.933333333333333,4.77,NA,NA,NA,NA,NA,-10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-1,0,1,-2,-2,0,0,2,-0.0863728470111449,-0.130490956072351,0.00539164766643114,-0.195907928388747,-0.117801047120419,0.0315789473684211,0.225320512820513,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.389,0.842,"4:2","124/150","L:N:V:C:R:Y:H:F:W:G:S:A:T:P",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage4","dr_mutations_pyrazinamide","ASN",0,"ERR1035323","ERR1035323","lineage4.3.3","br","Brazil","pnca_p.thr168asn","A","H","THR","TA168","pnca_complex.pdb"
|
|
"T168P","L2","PZA","T","T168",168,"P",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",10.468,-1.31,0.151,3.22365,-1.21,0.61,49,71,0.703,2,2,24,0.13953488372093,"helix",0.933333333333333,4.77,NA,NA,NA,NA,NA,0,-2,0,0,-2,0,0,0,0,4,2,0,2,0,0,0,0,0,4,0,-4,2,0,2,-2,-0.331813576494427,0.128401360544218,0.117412350031687,-0.206308610400682,0.342696629213483,0.515789473684211,0.225320512820513,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",0.389,0.842,"4:2","124/150","L:N:V:C:R:Y:H:F:W:G:S:A:T:P",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage2","dr_mutations_pyrazinamide","PRO",0,"SAMN02414858","SRR1162695_SRR1166879_SRR1165549_SRR1165524","lineage2.2.1","se","Sweden","pnca_p.thr168pro","A","H","THR","TA168","pnca_complex.pdb"
|
|
"T168P","L2","PZA","T","T168",168,"P",NA,"Pre-MDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",10.468,-1.31,0.151,3.22365,-1.21,0.61,49,71,0.703,2,2,24,0.13953488372093,"helix",0.933333333333333,4.77,NA,NA,NA,NA,NA,0,-2,0,0,-2,0,0,0,0,4,2,0,2,0,0,0,0,0,4,0,-4,2,0,2,-2,-0.331813576494427,0.128401360544218,0.117412350031687,-0.206308610400682,0.342696629213483,0.515789473684211,0.225320512820513,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",0.389,0.842,"4:2","124/150","L:N:V:C:R:Y:H:F:W:G:S:A:T:P",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage2","dr_mutations_pyrazinamide","PRO",0,"ERR1023296","ERR1023296","lineage2.2.1","","","pnca_p.thr168pro","A","H","THR","TA168","pnca_complex.pdb"
|
|
"T168P","L2","PZA","T","T168",168,"P",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",10.468,-1.31,0.151,3.22365,-1.21,0.61,49,71,0.703,2,2,24,0.13953488372093,"helix",0.933333333333333,4.77,NA,NA,NA,NA,NA,0,-2,0,0,-2,0,0,0,0,4,2,0,2,0,0,0,0,0,4,0,-4,2,0,2,-2,-0.331813576494427,0.128401360544218,0.117412350031687,-0.206308610400682,0.342696629213483,0.515789473684211,0.225320512820513,"Destabilising","Stabilising","Destabilising","Destabilising","Stabilising","effect",0.389,0.842,"4:2","124/150","L:N:V:C:R:Y:H:F:W:G:S:A:T:P",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage2","dr_mutations_pyrazinamide","PRO",0,"ERR1035012","ERR1035012","lineage2.2.1","za","South Africa","pnca_p.thr168pro","A","H","THR","TA168","pnca_complex.pdb"
|
|
"T168S","L3","PZA","T","T168",168,"S",1,"Pre-XDR","OM","hydrophobic","hydrophilic","neutral","neutral","polar","polar",10.468,-0.83,-0.382,0.47424,-0.28,0.09,-71,87,0.703,2,2,24,0.13953488372093,"helix",0.933333333333333,4.77,0.0002874802357337,1.61648444070648,1.61648999729673,1.61641362774286,5.75148528770432e-25,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,2,0,2,0,2,0,2,4,-0.210233029381966,-0.0987080103359173,0.0172728530947924,-0.0477408354646206,0.0505617977528089,-0.763440860215054,0.225320512820513,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","neutral",0.389,0.842,"4:2","124/150","L:N:V:C:R:Y:H:F:W:G:S:A:T:P",0.480257130287145,0.677247786834332,1.1538493489906,0.416221693678882,0.0799389646162879,12.6318165284439,0.208571528713835,0.527693668101443,0.277618116975238,0.0307788891197694,20.1401594005,0.999999999999395,"lineage3","other_mutations_pyrazinamide","SER",0,"ERR2510560","ERR2510560","lineage3","pk","Pakistan","pnca_p.thr168ser","A","H","THR","TA168","pnca_complex.pdb"
|
|
"T168S","L3","PZA","T","T168",168,"S",0,"MDR","OM","hydrophobic","hydrophilic","neutral","neutral","polar","polar",10.468,-0.83,-0.382,0.47424,-0.28,0.09,-71,87,0.703,2,2,24,0.13953488372093,"helix",0.933333333333333,4.77,0.0002874802357337,1.61648444070648,1.61648999729673,1.61641362774286,5.75148528770432e-25,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,2,0,2,0,2,0,2,4,-0.210233029381966,-0.0987080103359173,0.0172728530947924,-0.0477408354646206,0.0505617977528089,-0.763440860215054,0.225320512820513,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","neutral",0.389,0.842,"4:2","124/150","L:N:V:C:R:Y:H:F:W:G:S:A:T:P",0.480257130287145,0.677247786834332,1.1538493489906,0.416221693678882,0.0799389646162879,12.6318165284439,0.208571528713835,0.527693668101443,0.277618116975238,0.0307788891197694,20.1401594005,0.999999999999395,"lineage3","other_mutations_pyrazinamide","SER",0,"SAMN03648011,SRR2100838","SRR2100838","lineage3","","","pnca_p.thr168ser","A","H","THR","TA168","pnca_complex.pdb"
|
|
"T168S","L3","PZA","T","T168",168,"S",0,"MDR","OM","hydrophobic","hydrophilic","neutral","neutral","polar","polar",10.468,-0.83,-0.382,0.47424,-0.28,0.09,-71,87,0.703,2,2,24,0.13953488372093,"helix",0.933333333333333,4.77,0.0002874802357337,1.61648444070648,1.61648999729673,1.61641362774286,5.75148528770432e-25,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,2,0,2,0,2,0,2,4,-0.210233029381966,-0.0987080103359173,0.0172728530947924,-0.0477408354646206,0.0505617977528089,-0.763440860215054,0.225320512820513,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","neutral",0.389,0.842,"4:2","124/150","L:N:V:C:R:Y:H:F:W:G:S:A:T:P",0.480257130287145,0.677247786834332,1.1538493489906,0.416221693678882,0.0799389646162879,12.6318165284439,0.208571528713835,0.527693668101443,0.277618116975238,0.0307788891197694,20.1401594005,0.999999999999395,"lineage3","other_mutations_pyrazinamide","SER",0,"ERR2510439","ERR2510439","lineage3","pk","Pakistan","pnca_p.thr168ser","A","H","THR","TA168","pnca_complex.pdb"
|
|
"T168S","L3","PZA","T","T168",168,"S",0,"MDR","OM","hydrophobic","hydrophilic","neutral","neutral","polar","polar",10.468,-0.83,-0.382,0.47424,-0.28,0.09,-71,87,0.703,2,2,24,0.13953488372093,"helix",0.933333333333333,4.77,0.0002874802357337,1.61648444070648,1.61648999729673,1.61641362774286,5.75148528770432e-25,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,2,0,2,0,2,0,2,4,-0.210233029381966,-0.0987080103359173,0.0172728530947924,-0.0477408354646206,0.0505617977528089,-0.763440860215054,0.225320512820513,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","neutral",0.389,0.842,"4:2","124/150","L:N:V:C:R:Y:H:F:W:G:S:A:T:P",0.480257130287145,0.677247786834332,1.1538493489906,0.416221693678882,0.0799389646162879,12.6318165284439,0.208571528713835,0.527693668101443,0.277618116975238,0.0307788891197694,20.1401594005,0.999999999999395,"lineage3","other_mutations_pyrazinamide","SER",0,"ERR2517093","ERR2517093","lineage3","gb","UK","pnca_p.thr168ser","A","H","THR","TA168","pnca_complex.pdb"
|
|
"A171E","L2","PZA","A","A171",171,"E",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","non-polar","acidic","non-polar","neg",10.476,1.116,-2.671,3.52921,-3.951,-0.69,75,85,-0.872,8,8,5,0.0387596899224806,"helix",2.46666666666667,5.33,0.0001437401178668,1.2119588062211,4.59700131334266e-05,0,1.01056822389159e-25,-36,-26,0,0,-26,0,0,0,0,0,0,0,0,0,0,0,0,-1,0,-3,-3,0,0,0,-5,0.500448430493273,-0.690180878552972,0.128541510354825,-0.673657289002558,-0.180628272251309,0.789473684210526,-0.71828665568369,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","122/150","R:C:V:T:E:A",-9.98752126245058,0.942832958100734,139.277183325398,-0.0717096729269461,NA,144471.706314849,0.0834878586628579,1,0,0,25.8386585962163,0.999999999999746,"lineage2","dr_mutations_pyrazinamide","GLU",0,"SAMN02584620","SRR1169146_SRR1166097","lineage2.2.1","md","Moldova","pnca_p.ala171glu","A","H","ALA","AA171","pnca_complex.pdb"
|
|
"A171E","L2","PZA","A","A171",171,"E",NA,"Pre-MDR","DM","hydrophobic","hydrophilic","non-polar","acidic","non-polar","neg",10.476,1.116,-2.671,3.52921,-3.951,-0.69,75,85,-0.872,8,8,5,0.0387596899224806,"helix",2.46666666666667,5.33,0.0001437401178668,1.2119588062211,4.59700131334266e-05,0,1.01056822389159e-25,-36,-26,0,0,-26,0,0,0,0,0,0,0,0,0,0,0,0,-1,0,-3,-3,0,0,0,-5,0.500448430493273,-0.690180878552972,0.128541510354825,-0.673657289002558,-0.180628272251309,0.789473684210526,-0.71828665568369,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","122/150","R:C:V:T:E:A",-9.98752126245058,0.942832958100734,139.277183325398,-0.0717096729269461,NA,144471.706314849,0.0834878586628579,1,0,0,25.8386585962163,0.999999999999746,"lineage2","dr_mutations_pyrazinamide","GLU",0,"SRR5073723","SRR5073723","lineage2.2.1","vn","Vietnam","pnca_p.ala171glu","A","H","ALA","AA171","pnca_complex.pdb"
|
|
"A171E","L2","PZA","A","A171",171,"E",NA,"Pre-MDR","DM","hydrophobic","hydrophilic","non-polar","acidic","non-polar","neg",10.476,1.116,-2.671,3.52921,-3.951,-0.69,75,85,-0.872,8,8,5,0.0387596899224806,"helix",2.46666666666667,5.33,0.0001437401178668,1.2119588062211,4.59700131334266e-05,0,1.01056822389159e-25,-36,-26,0,0,-26,0,0,0,0,0,0,0,0,0,0,0,0,-1,0,-3,-3,0,0,0,-5,0.500448430493273,-0.690180878552972,0.128541510354825,-0.673657289002558,-0.180628272251309,0.789473684210526,-0.71828665568369,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","122/150","R:C:V:T:E:A",-9.98752126245058,0.942832958100734,139.277183325398,-0.0717096729269461,NA,144471.706314849,0.0834878586628579,1,0,0,25.8386585962163,0.999999999999746,"lineage2","dr_mutations_pyrazinamide","GLU",0,"SRR5073505","SRR5073505","lineage2.2.1","vn","Vietnam","pnca_p.ala171glu","A","H","ALA","AA171","pnca_complex.pdb"
|
|
"A171E","L2","PZA","A","A171",171,"E",0,"XDR","DM","hydrophobic","hydrophilic","non-polar","acidic","non-polar","neg",10.476,1.116,-2.671,3.52921,-3.951,-0.69,75,85,-0.872,8,8,5,0.0387596899224806,"helix",2.46666666666667,5.33,0.0001437401178668,1.2119588062211,4.59700131334266e-05,0,1.01056822389159e-25,-36,-26,0,0,-26,0,0,0,0,0,0,0,0,0,0,0,0,-1,0,-3,-3,0,0,0,-5,0.500448430493273,-0.690180878552972,0.128541510354825,-0.673657289002558,-0.180628272251309,0.789473684210526,-0.71828665568369,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","122/150","R:C:V:T:E:A",-9.98752126245058,0.942832958100734,139.277183325398,-0.0717096729269461,NA,144471.706314849,0.0834878586628579,1,0,0,25.8386585962163,0.999999999999746,"lineage2","dr_mutations_pyrazinamide","GLU",0,"ERR553196,SAMEA2535204","ERR553196","lineage2.2.1","","","pnca_p.ala171glu","A","H","ALA","AA171","pnca_complex.pdb"
|
|
"A171E","L2","PZA","A","A171",171,"E",0,"XDR","DM","hydrophobic","hydrophilic","non-polar","acidic","non-polar","neg",10.476,1.116,-2.671,3.52921,-3.951,-0.69,75,85,-0.872,8,8,5,0.0387596899224806,"helix",2.46666666666667,5.33,0.0001437401178668,1.2119588062211,4.59700131334266e-05,0,1.01056822389159e-25,-36,-26,0,0,-26,0,0,0,0,0,0,0,0,0,0,0,0,-1,0,-3,-3,0,0,0,-5,0.500448430493273,-0.690180878552972,0.128541510354825,-0.673657289002558,-0.180628272251309,0.789473684210526,-0.71828665568369,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","122/150","R:C:V:T:E:A",-9.98752126245058,0.942832958100734,139.277183325398,-0.0717096729269461,NA,144471.706314849,0.0834878586628579,1,0,0,25.8386585962163,0.999999999999746,"lineage2","dr_mutations_pyrazinamide","GLU",0,"ERR2517070","ERR2517070","lineage2.2.1","gb","UK","pnca_p.ala171glu","A","H","ALA","AA171","pnca_complex.pdb"
|
|
"A171P","L4","PZA","A","A171",171,"P",NA,"MDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",10.476,-1.239,-1.241,4.26761,-3.012,-0.05,80,91,-0.872,8,8,5,0.0387596899224806,"helix",2.46666666666667,5.33,NA,NA,NA,NA,NA,-2,0,0,0,0,0,0,0,0,4,2,0,0,0,0,0,0,-3,4,-5,-4,4,0,2,1,-0.313829787234043,-0.320671834625323,0.155435645655927,-0.513554987212276,-0.013089005235602,0.842105263157895,-0.71828665568369,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","122/150","R:C:V:T:E:A",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR1213889","ERR1213889","lineage4.3.4.2.1","rw","Rwanda","pnca_p.ala171pro","A","H","ALA","AA171","pnca_complex.pdb"
|
|
"A171P","L4","PZA","A","A171",171,"P",NA,"MDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",10.476,-1.239,-1.241,4.26761,-3.012,-0.05,80,91,-0.872,8,8,5,0.0387596899224806,"helix",2.46666666666667,5.33,NA,NA,NA,NA,NA,-2,0,0,0,0,0,0,0,0,4,2,0,0,0,0,0,0,-3,4,-5,-4,4,0,2,1,-0.313829787234043,-0.320671834625323,0.155435645655927,-0.513554987212276,-0.013089005235602,0.842105263157895,-0.71828665568369,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","122/150","R:C:V:T:E:A",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR1035270","ERR1035270","lineage4.3.4.2","br","Brazil","pnca_p.ala171pro","A","H","ALA","AA171","pnca_complex.pdb"
|
|
"A171T","L3","PZA","A","A171",171,"T",0,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",10.476,0.043,-1.816,0.486585,-1.914,-1.47,25,63,-0.872,8,8,5,0.0387596899224806,"helix",2.46666666666667,5.33,0.0003593502946672,0.484657419083649,1.69068633684891e-05,0,0.177777263899814,-2,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,-3,0,-1,-2,0,0,0,-5,0.0192825112107623,-0.469250645994832,0.0177224848665856,-0.326342710997442,-0.384816753926702,0.263157894736842,-0.71828665568369,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","122/150","R:C:V:T:E:A",-10.9877909019996,0.93969121942854,145.229797681913,-0.075657964669657,NA,60.3389082676185,-0.314565134742567,0.596111875058711,0.224672226566594,0,5.29224350433385,0.673290424524484,"lineage3","dr_mutations_pyrazinamide","THR",0,"ERR2510582","ERR2510582","lineage3","pk","Pakistan","pnca_p.ala171thr","A","H","ALA","AA171","pnca_complex.pdb"
|
|
"A171T","L3","PZA","A","A171",171,"T",0,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",10.476,0.043,-1.816,0.486585,-1.914,-1.47,25,63,-0.872,8,8,5,0.0387596899224806,"helix",2.46666666666667,5.33,0.0003593502946672,0.484657419083649,1.69068633684891e-05,0,0.177777263899814,-2,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,-3,0,-1,-2,0,0,0,-5,0.0192825112107623,-0.469250645994832,0.0177224848665856,-0.326342710997442,-0.384816753926702,0.263157894736842,-0.71828665568369,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","122/150","R:C:V:T:E:A",-10.9877909019996,0.93969121942854,145.229797681913,-0.075657964669657,NA,60.3389082676185,-0.314565134742567,0.596111875058711,0.224672226566594,0,5.29224350433385,0.673290424524484,"lineage3","dr_mutations_pyrazinamide","THR",0,"ERR2510581","ERR2510581","lineage3","pk","Pakistan","pnca_p.ala171thr","A","H","ALA","AA171","pnca_complex.pdb"
|
|
"A171T","L2","PZA","A","A171",171,"T",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",10.476,0.043,-1.816,0.486585,-1.914,-1.47,25,63,-0.872,8,8,5,0.0387596899224806,"helix",2.46666666666667,5.33,0.0003593502946672,0.484657419083649,1.69068633684891e-05,0,0.177777263899814,-2,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,-3,0,-1,-2,0,0,0,-5,0.0192825112107623,-0.469250645994832,0.0177224848665856,-0.326342710997442,-0.384816753926702,0.263157894736842,-0.71828665568369,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","122/150","R:C:V:T:E:A",-10.9877909019996,0.93969121942854,145.229797681913,-0.075657964669657,NA,60.3389082676185,-0.314565134742567,0.596111875058711,0.224672226566594,0,5.29224350433385,0.673290424524484,"lineage2","dr_mutations_pyrazinamide","THR",0,"SRR6397947","SRR6397947","lineage2.2.1","ca","Canada","pnca_p.ala171thr","A","H","ALA","AA171","pnca_complex.pdb"
|
|
"A171T","L3","PZA","A","A171",171,"T",0,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",10.476,0.043,-1.816,0.486585,-1.914,-1.47,25,63,-0.872,8,8,5,0.0387596899224806,"helix",2.46666666666667,5.33,0.0003593502946672,0.484657419083649,1.69068633684891e-05,0,0.177777263899814,-2,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,-3,0,-1,-2,0,0,0,-5,0.0192825112107623,-0.469250645994832,0.0177224848665856,-0.326342710997442,-0.384816753926702,0.263157894736842,-0.71828665568369,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","122/150","R:C:V:T:E:A",-10.9877909019996,0.93969121942854,145.229797681913,-0.075657964669657,NA,60.3389082676185,-0.314565134742567,0.596111875058711,0.224672226566594,0,5.29224350433385,0.673290424524484,"lineage3","dr_mutations_pyrazinamide","THR",0,"ERR2510415","ERR2510415","lineage3","pk","Pakistan","pnca_p.ala171thr","A","H","ALA","AA171","pnca_complex.pdb"
|
|
"A171T","L4","PZA","A","A171",171,"T",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",10.476,0.043,-1.816,0.486585,-1.914,-1.47,25,63,-0.872,8,8,5,0.0387596899224806,"helix",2.46666666666667,5.33,0.0003593502946672,0.484657419083649,1.69068633684891e-05,0,0.177777263899814,-2,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,-3,0,-1,-2,0,0,0,-5,0.0192825112107623,-0.469250645994832,0.0177224848665856,-0.326342710997442,-0.384816753926702,0.263157894736842,-0.71828665568369,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","122/150","R:C:V:T:E:A",-10.9877909019996,0.93969121942854,145.229797681913,-0.075657964669657,NA,60.3389082676185,-0.314565134742567,0.596111875058711,0.224672226566594,0,5.29224350433385,0.673290424524484,"lineage4","dr_mutations_pyrazinamide","THR",0,"ERR751470","ERR751470","lineage4.1.1.3","pe","","pnca_p.ala171thr","A","H","ALA","AA171","pnca_complex.pdb"
|
|
"A171T","L4","PZA","A","A171",171,"T",0,"XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",10.476,0.043,-1.816,0.486585,-1.914,-1.47,25,63,-0.872,8,8,5,0.0387596899224806,"helix",2.46666666666667,5.33,0.0003593502946672,0.484657419083649,1.69068633684891e-05,0,0.177777263899814,-2,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,-3,0,-1,-2,0,0,0,-5,0.0192825112107623,-0.469250645994832,0.0177224848665856,-0.326342710997442,-0.384816753926702,0.263157894736842,-0.71828665568369,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","122/150","R:C:V:T:E:A",-10.9877909019996,0.93969121942854,145.229797681913,-0.075657964669657,NA,60.3389082676185,-0.314565134742567,0.596111875058711,0.224672226566594,0,5.29224350433385,0.673290424524484,"lineage4","dr_mutations_pyrazinamide","THR",0,"ERR2510705","ERR2510705","lineage4.8","it","Italy","pnca_p.ala171thr","A","H","ALA","AA171","pnca_complex.pdb"
|
|
"A171T","L3","PZA","A","A171",171,"T",0,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",10.476,0.043,-1.816,0.486585,-1.914,-1.47,25,63,-0.872,8,8,5,0.0387596899224806,"helix",2.46666666666667,5.33,0.0003593502946672,0.484657419083649,1.69068633684891e-05,0,0.177777263899814,-2,0,0,0,0,0,0,0,0,0,0,-2,0,0,0,0,0,-3,0,-1,-2,0,0,0,-5,0.0192825112107623,-0.469250645994832,0.0177224848665856,-0.326342710997442,-0.384816753926702,0.263157894736842,-0.71828665568369,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","122/150","R:C:V:T:E:A",-10.9877909019996,0.93969121942854,145.229797681913,-0.075657964669657,NA,60.3389082676185,-0.314565134742567,0.596111875058711,0.224672226566594,0,5.29224350433385,0.673290424524484,"lineage3","dr_mutations_pyrazinamide","THR",0,"ERR2510573","ERR2510573","lineage3","pk","Pakistan","pnca_p.ala171thr","A","H","ALA","AA171","pnca_complex.pdb"
|
|
"A171V","L2","PZA","A","A171",171,"V",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",10.476,-1.298,-0.659,0.499158,-1.528,-0.62,38,66,-0.872,8,8,5,0.0387596899224806,"helix",2.46666666666667,5.33,0.0001437401178668,4.85029436501262,4.85029432717736,4.84956447904112,0.0881192621863332,-2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-5,-6,2,0,2,-1,-0.328774062816616,-0.170284237726098,0.0181804208946743,-0.260528559249787,-0.162303664921466,0.4,-0.71828665568369,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","122/150","R:C:V:T:E:A",1.57903938912402,0.264247566376722,1.41439286276584,1.11640791656443,0.191756076673654,122.683760399096,0.685768096792206,0.312734154310187,0.504824686014995,0.061763864579114,379.558337204203,0.766581879696361,"lineage2","dr_mutations_pyrazinamide","VAL",0,"ERR502955","ERR502955","lineage2.2.1","","","pnca_p.ala171val","A","H","ALA","AA171","pnca_complex.pdb"
|
|
"A171V","L2","PZA","A","A171",171,"V",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",10.476,-1.298,-0.659,0.499158,-1.528,-0.62,38,66,-0.872,8,8,5,0.0387596899224806,"helix",2.46666666666667,5.33,0.0001437401178668,4.85029436501262,4.85029432717736,4.84956447904112,0.0881192621863332,-2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-5,-6,2,0,2,-1,-0.328774062816616,-0.170284237726098,0.0181804208946743,-0.260528559249787,-0.162303664921466,0.4,-0.71828665568369,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","122/150","R:C:V:T:E:A",1.57903938912402,0.264247566376722,1.41439286276584,1.11640791656443,0.191756076673654,122.683760399096,0.685768096792206,0.312734154310187,0.504824686014995,0.061763864579114,379.558337204203,0.766581879696361,"lineage2","dr_mutations_pyrazinamide","VAL",0,"ERR1352337","ERR1352337","lineage2.2.1","cn","China","pnca_p.ala171val","A","H","ALA","AA171","pnca_complex.pdb"
|
|
"A171V","L4","PZA","A","A171",171,"V",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",10.476,-1.298,-0.659,0.499158,-1.528,-0.62,38,66,-0.872,8,8,5,0.0387596899224806,"helix",2.46666666666667,5.33,0.0001437401178668,4.85029436501262,4.85029432717736,4.84956447904112,0.0881192621863332,-2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-5,-6,2,0,2,-1,-0.328774062816616,-0.170284237726098,0.0181804208946743,-0.260528559249787,-0.162303664921466,0.4,-0.71828665568369,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","122/150","R:C:V:T:E:A",1.57903938912402,0.264247566376722,1.41439286276584,1.11640791656443,0.191756076673654,122.683760399096,0.685768096792206,0.312734154310187,0.504824686014995,0.061763864579114,379.558337204203,0.766581879696361,"lineage4","dr_mutations_pyrazinamide","VAL",0,"ERR751626","ERR751626","lineage4.3.4.1","pe","","pnca_p.ala171val","A","H","ALA","AA171","pnca_complex.pdb"
|
|
"A171V","L4","PZA","A","A171",171,"V",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",10.476,-1.298,-0.659,0.499158,-1.528,-0.62,38,66,-0.872,8,8,5,0.0387596899224806,"helix",2.46666666666667,5.33,0.0001437401178668,4.85029436501262,4.85029432717736,4.84956447904112,0.0881192621863332,-2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-5,-6,2,0,2,-1,-0.328774062816616,-0.170284237726098,0.0181804208946743,-0.260528559249787,-0.162303664921466,0.4,-0.71828665568369,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","122/150","R:C:V:T:E:A",1.57903938912402,0.264247566376722,1.41439286276584,1.11640791656443,0.191756076673654,122.683760399096,0.685768096792206,0.312734154310187,0.504824686014995,0.061763864579114,379.558337204203,0.766581879696361,"lineage4","dr_mutations_pyrazinamide","VAL",0,"ERR751401","ERR751401","lineage4.3.3","pe","","pnca_p.ala171val","A","H","ALA","AA171","pnca_complex.pdb"
|
|
"A171V","L4","PZA","A","A171",171,"V",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",10.476,-1.298,-0.659,0.499158,-1.528,-0.62,38,66,-0.872,8,8,5,0.0387596899224806,"helix",2.46666666666667,5.33,0.0001437401178668,4.85029436501262,4.85029432717736,4.84956447904112,0.0881192621863332,-2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-5,-6,2,0,2,-1,-0.328774062816616,-0.170284237726098,0.0181804208946743,-0.260528559249787,-0.162303664921466,0.4,-0.71828665568369,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","122/150","R:C:V:T:E:A",1.57903938912402,0.264247566376722,1.41439286276584,1.11640791656443,0.191756076673654,122.683760399096,0.685768096792206,0.312734154310187,0.504824686014995,0.061763864579114,379.558337204203,0.766581879696361,"lineage4","dr_mutations_pyrazinamide","VAL",0,"ERR1035359","ERR1035359","lineage4.3.4.1","br","Brazil","pnca_p.ala171val","A","H","ALA","AA171","pnca_complex.pdb"
|
|
"A171V","L2","PZA","A","A171",171,"V",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",10.476,-1.298,-0.659,0.499158,-1.528,-0.62,38,66,-0.872,8,8,5,0.0387596899224806,"helix",2.46666666666667,5.33,0.0001437401178668,4.85029436501262,4.85029432717736,4.84956447904112,0.0881192621863332,-2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-5,-6,2,0,2,-1,-0.328774062816616,-0.170284237726098,0.0181804208946743,-0.260528559249787,-0.162303664921466,0.4,-0.71828665568369,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","122/150","R:C:V:T:E:A",1.57903938912402,0.264247566376722,1.41439286276584,1.11640791656443,0.191756076673654,122.683760399096,0.685768096792206,0.312734154310187,0.504824686014995,0.061763864579114,379.558337204203,0.766581879696361,"lineage2","dr_mutations_pyrazinamide","VAL",0,"SAMN02414972","SRR1167080_SRR1162848_SRR1166870_SRR1165437","lineage2.2.1","se","Sweden","pnca_p.ala171val","A","H","ALA","AA171","pnca_complex.pdb"
|
|
"A171V","L2","PZA","A","A171",171,"V",0,"XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",10.476,-1.298,-0.659,0.499158,-1.528,-0.62,38,66,-0.872,8,8,5,0.0387596899224806,"helix",2.46666666666667,5.33,0.0001437401178668,4.85029436501262,4.85029432717736,4.84956447904112,0.0881192621863332,-2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-5,-6,2,0,2,-1,-0.328774062816616,-0.170284237726098,0.0181804208946743,-0.260528559249787,-0.162303664921466,0.4,-0.71828665568369,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","122/150","R:C:V:T:E:A",1.57903938912402,0.264247566376722,1.41439286276584,1.11640791656443,0.191756076673654,122.683760399096,0.685768096792206,0.312734154310187,0.504824686014995,0.061763864579114,379.558337204203,0.766581879696361,"lineage2","dr_mutations_pyrazinamide","VAL",0,"ERR2510840","ERR2510840","lineage2.2.1","it","Italy","pnca_p.ala171val","A","H","ALA","AA171","pnca_complex.pdb"
|
|
"A171V","L2","PZA","A","A171",171,"V",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",10.476,-1.298,-0.659,0.499158,-1.528,-0.62,38,66,-0.872,8,8,5,0.0387596899224806,"helix",2.46666666666667,5.33,0.0001437401178668,4.85029436501262,4.85029432717736,4.84956447904112,0.0881192621863332,-2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-5,-6,2,0,2,-1,-0.328774062816616,-0.170284237726098,0.0181804208946743,-0.260528559249787,-0.162303664921466,0.4,-0.71828665568369,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","122/150","R:C:V:T:E:A",1.57903938912402,0.264247566376722,1.41439286276584,1.11640791656443,0.191756076673654,122.683760399096,0.685768096792206,0.312734154310187,0.504824686014995,0.061763864579114,379.558337204203,0.766581879696361,"lineage2","dr_mutations_pyrazinamide","VAL",0,"SRS796987","SRR1723476","lineage2.2.1","cn","China:Guizhou","pnca_p.ala171val","A","H","ALA","AA171","pnca_complex.pdb"
|
|
"A171V","L2","PZA","A","A171",171,"V",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",10.476,-1.298,-0.659,0.499158,-1.528,-0.62,38,66,-0.872,8,8,5,0.0387596899224806,"helix",2.46666666666667,5.33,0.0001437401178668,4.85029436501262,4.85029432717736,4.84956447904112,0.0881192621863332,-2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-5,-6,2,0,2,-1,-0.328774062816616,-0.170284237726098,0.0181804208946743,-0.260528559249787,-0.162303664921466,0.4,-0.71828665568369,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","122/150","R:C:V:T:E:A",1.57903938912402,0.264247566376722,1.41439286276584,1.11640791656443,0.191756076673654,122.683760399096,0.685768096792206,0.312734154310187,0.504824686014995,0.061763864579114,379.558337204203,0.766581879696361,"lineage2","dr_mutations_pyrazinamide","VAL",0,"ERR1352334","ERR1352334","lineage2.2.1","cn","China","pnca_p.ala171val","A","H","ALA","AA171","pnca_complex.pdb"
|
|
"A171V","L2","PZA","A","A171",171,"V",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",10.476,-1.298,-0.659,0.499158,-1.528,-0.62,38,66,-0.872,8,8,5,0.0387596899224806,"helix",2.46666666666667,5.33,0.0001437401178668,4.85029436501262,4.85029432717736,4.84956447904112,0.0881192621863332,-2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-5,-6,2,0,2,-1,-0.328774062816616,-0.170284237726098,0.0181804208946743,-0.260528559249787,-0.162303664921466,0.4,-0.71828665568369,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","122/150","R:C:V:T:E:A",1.57903938912402,0.264247566376722,1.41439286276584,1.11640791656443,0.191756076673654,122.683760399096,0.685768096792206,0.312734154310187,0.504824686014995,0.061763864579114,379.558337204203,0.766581879696361,"lineage2","dr_mutations_pyrazinamide","VAL",0,"SRS797333","SRR1723865_SRR1723864","lineage2.2.1","cn","China:Jiangxi","pnca_p.ala171val","A","H","ALA","AA171","pnca_complex.pdb"
|
|
"A171V","L2","PZA","A","A171",171,"V",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",10.476,-1.298,-0.659,0.499158,-1.528,-0.62,38,66,-0.872,8,8,5,0.0387596899224806,"helix",2.46666666666667,5.33,0.0001437401178668,4.85029436501262,4.85029432717736,4.84956447904112,0.0881192621863332,-2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-5,-6,2,0,2,-1,-0.328774062816616,-0.170284237726098,0.0181804208946743,-0.260528559249787,-0.162303664921466,0.4,-0.71828665568369,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","122/150","R:C:V:T:E:A",1.57903938912402,0.264247566376722,1.41439286276584,1.11640791656443,0.191756076673654,122.683760399096,0.685768096792206,0.312734154310187,0.504824686014995,0.061763864579114,379.558337204203,0.766581879696361,"lineage2","dr_mutations_pyrazinamide","VAL",0,"ERR1352339","ERR1352339","lineage2.2.1","cn","China","pnca_p.ala171val","A","H","ALA","AA171","pnca_complex.pdb"
|
|
"A171V","L2","PZA","A","A171",171,"V",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",10.476,-1.298,-0.659,0.499158,-1.528,-0.62,38,66,-0.872,8,8,5,0.0387596899224806,"helix",2.46666666666667,5.33,0.0001437401178668,4.85029436501262,4.85029432717736,4.84956447904112,0.0881192621863332,-2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-5,-6,2,0,2,-1,-0.328774062816616,-0.170284237726098,0.0181804208946743,-0.260528559249787,-0.162303664921466,0.4,-0.71828665568369,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","122/150","R:C:V:T:E:A",1.57903938912402,0.264247566376722,1.41439286276584,1.11640791656443,0.191756076673654,122.683760399096,0.685768096792206,0.312734154310187,0.504824686014995,0.061763864579114,379.558337204203,0.766581879696361,"lineage2","dr_mutations_pyrazinamide","VAL",0,"ERR1352338","ERR1352338","lineage2.2.1","cn","China","pnca_p.ala171val","A","H","ALA","AA171","pnca_complex.pdb"
|
|
"A171V","L2","PZA","A","A171",171,"V",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",10.476,-1.298,-0.659,0.499158,-1.528,-0.62,38,66,-0.872,8,8,5,0.0387596899224806,"helix",2.46666666666667,5.33,0.0001437401178668,4.85029436501262,4.85029432717736,4.84956447904112,0.0881192621863332,-2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-5,-6,2,0,2,-1,-0.328774062816616,-0.170284237726098,0.0181804208946743,-0.260528559249787,-0.162303664921466,0.4,-0.71828665568369,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","122/150","R:C:V:T:E:A",1.57903938912402,0.264247566376722,1.41439286276584,1.11640791656443,0.191756076673654,122.683760399096,0.685768096792206,0.312734154310187,0.504824686014995,0.061763864579114,379.558337204203,0.766581879696361,"lineage2","dr_mutations_pyrazinamide","VAL",0,"ERR1352336","ERR1352336","lineage2.2.1","cn","China","pnca_p.ala171val","A","H","ALA","AA171","pnca_complex.pdb"
|
|
"A171V","L2","PZA","A","A171",171,"V",1,"Pre-MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",10.476,-1.298,-0.659,0.499158,-1.528,-0.62,38,66,-0.872,8,8,5,0.0387596899224806,"helix",2.46666666666667,5.33,0.0001437401178668,4.85029436501262,4.85029432717736,4.84956447904112,0.0881192621863332,-2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-5,-6,2,0,2,-1,-0.328774062816616,-0.170284237726098,0.0181804208946743,-0.260528559249787,-0.162303664921466,0.4,-0.71828665568369,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","122/150","R:C:V:T:E:A",1.57903938912402,0.264247566376722,1.41439286276584,1.11640791656443,0.191756076673654,122.683760399096,0.685768096792206,0.312734154310187,0.504824686014995,0.061763864579114,379.558337204203,0.766581879696361,"lineage2","dr_mutations_pyrazinamide","VAL",0,"MDR_14236","SRR6824369","lineage2.2.1","cn","China: Jinxian County, Nanchang City, Jiangxi Province","pnca_p.ala171val","A","H","ALA","AA171","pnca_complex.pdb"
|
|
"A171V","L2","PZA","A","A171",171,"V",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",10.476,-1.298,-0.659,0.499158,-1.528,-0.62,38,66,-0.872,8,8,5,0.0387596899224806,"helix",2.46666666666667,5.33,0.0001437401178668,4.85029436501262,4.85029432717736,4.84956447904112,0.0881192621863332,-2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7,0,-5,-6,2,0,2,-1,-0.328774062816616,-0.170284237726098,0.0181804208946743,-0.260528559249787,-0.162303664921466,0.4,-0.71828665568369,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.993,-0.827,"9:8","122/150","R:C:V:T:E:A",1.57903938912402,0.264247566376722,1.41439286276584,1.11640791656443,0.191756076673654,122.683760399096,0.685768096792206,0.312734154310187,0.504824686014995,0.061763864579114,379.558337204203,0.766581879696361,"lineage2","dr_mutations_pyrazinamide","VAL",0,"ERR1352335","ERR1352335","lineage2.2.1","cn","China","pnca_p.ala171val","A","H","ALA","AA171","pnca_complex.pdb"
|
|
"L172P","L4","PZA","L","L172",172,"P",NA,"MDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",13.187,-1.353,-1.821,4.7117,-2.793,-1.44,79,85,1.192,1,1,51,0.253731343283582,"helix",0.7,4.4,0.0007187005893344,43.8,43.7999992563294,43.791882510185,32.5514826715601,14,0,0,0,0,0,0,0,0,2,2,0,0,0,0,0,0,3,4,1,-1,2,0,-2,4,-0.342705167173252,-0.470542635658915,0.17161037012216,-0.476214833759591,-0.37696335078534,0.831578947368421,0.382051282051282,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.59,1.183,"3:1","122/150","H:F:E:L:V:K:R:C:I:T:A:M:D:W",3.77963380040362,0.000336884092116,1.0542469487651,3.58515033392406,8.22614212186537,807.950983717549,1.6414741105041,1.04401171857701e-06,5.98129462653992,6.06119169154248,1899.94618136838,1.16076545932747e-08,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR751403","ERR751403","lineage4.3.3","pe","","pnca_p.leu172pro","A","H","LEU","LA172","pnca_complex.pdb"
|
|
"L172P","L2","PZA","L","L172",172,"P",NA,"XDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",13.187,-1.353,-1.821,4.7117,-2.793,-1.44,79,85,1.192,1,1,51,0.253731343283582,"helix",0.7,4.4,0.0007187005893344,43.8,43.7999992563294,43.791882510185,32.5514826715601,14,0,0,0,0,0,0,0,0,2,2,0,0,0,0,0,0,3,4,1,-1,2,0,-2,4,-0.342705167173252,-0.470542635658915,0.17161037012216,-0.476214833759591,-0.37696335078534,0.831578947368421,0.382051282051282,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.59,1.183,"3:1","122/150","H:F:E:L:V:K:R:C:I:T:A:M:D:W",3.77963380040362,0.000336884092116,1.0542469487651,3.58515033392406,8.22614212186537,807.950983717549,1.6414741105041,1.04401171857701e-06,5.98129462653992,6.06119169154248,1899.94618136838,1.16076545932747e-08,"lineage2","dr_mutations_pyrazinamide","PRO",0,"SAMN02419606","SRR1172387_SRR1169050_SRR1163429_SRR1163025","lineage2.2.1","by","Belarus","pnca_p.leu172pro","A","H","LEU","LA172","pnca_complex.pdb"
|
|
"L172P","L4","PZA","L","L172",172,"P",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",13.187,-1.353,-1.821,4.7117,-2.793,-1.44,79,85,1.192,1,1,51,0.253731343283582,"helix",0.7,4.4,0.0007187005893344,43.8,43.7999992563294,43.791882510185,32.5514826715601,14,0,0,0,0,0,0,0,0,2,2,0,0,0,0,0,0,3,4,1,-1,2,0,-2,4,-0.342705167173252,-0.470542635658915,0.17161037012216,-0.476214833759591,-0.37696335078534,0.831578947368421,0.382051282051282,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.59,1.183,"3:1","122/150","H:F:E:L:V:K:R:C:I:T:A:M:D:W",3.77963380040362,0.000336884092116,1.0542469487651,3.58515033392406,8.22614212186537,807.950983717549,1.6414741105041,1.04401171857701e-06,5.98129462653992,6.06119169154248,1899.94618136838,1.16076545932747e-08,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR3256255","ERR3256255","lineage4.3.4.1","ph","Philippines","pnca_p.leu172pro","A","H","LEU","LA172","pnca_complex.pdb"
|
|
"L172P","L4","PZA","L","L172",172,"P",NA,"MDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",13.187,-1.353,-1.821,4.7117,-2.793,-1.44,79,85,1.192,1,1,51,0.253731343283582,"helix",0.7,4.4,0.0007187005893344,43.8,43.7999992563294,43.791882510185,32.5514826715601,14,0,0,0,0,0,0,0,0,2,2,0,0,0,0,0,0,3,4,1,-1,2,0,-2,4,-0.342705167173252,-0.470542635658915,0.17161037012216,-0.476214833759591,-0.37696335078534,0.831578947368421,0.382051282051282,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.59,1.183,"3:1","122/150","H:F:E:L:V:K:R:C:I:T:A:M:D:W",3.77963380040362,0.000336884092116,1.0542469487651,3.58515033392406,8.22614212186537,807.950983717549,1.6414741105041,1.04401171857701e-06,5.98129462653992,6.06119169154248,1899.94618136838,1.16076545932747e-08,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR1555044","ERR1555044","lineage4.3.4.2","","","pnca_p.leu172pro","A","H","LEU","LA172","pnca_complex.pdb"
|
|
"L172P","L4","PZA","L","L172",172,"P",1,"MDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",13.187,-1.353,-1.821,4.7117,-2.793,-1.44,79,85,1.192,1,1,51,0.253731343283582,"helix",0.7,4.4,0.0007187005893344,43.8,43.7999992563294,43.791882510185,32.5514826715601,14,0,0,0,0,0,0,0,0,2,2,0,0,0,0,0,0,3,4,1,-1,2,0,-2,4,-0.342705167173252,-0.470542635658915,0.17161037012216,-0.476214833759591,-0.37696335078534,0.831578947368421,0.382051282051282,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.59,1.183,"3:1","122/150","H:F:E:L:V:K:R:C:I:T:A:M:D:W",3.77963380040362,0.000336884092116,1.0542469487651,3.58515033392406,8.22614212186537,807.950983717549,1.6414741105041,1.04401171857701e-06,5.98129462653992,6.06119169154248,1899.94618136838,1.16076545932747e-08,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR1034832","ERR1034832","lineage4.8","pt","Portugal","pnca_p.leu172pro","A","H","LEU","LA172","pnca_complex.pdb"
|
|
"L172P","L2","PZA","L","L172",172,"P",1,"Pre-XDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",13.187,-1.353,-1.821,4.7117,-2.793,-1.44,79,85,1.192,1,1,51,0.253731343283582,"helix",0.7,4.4,0.0007187005893344,43.8,43.7999992563294,43.791882510185,32.5514826715601,14,0,0,0,0,0,0,0,0,2,2,0,0,0,0,0,0,3,4,1,-1,2,0,-2,4,-0.342705167173252,-0.470542635658915,0.17161037012216,-0.476214833759591,-0.37696335078534,0.831578947368421,0.382051282051282,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.59,1.183,"3:1","122/150","H:F:E:L:V:K:R:C:I:T:A:M:D:W",3.77963380040362,0.000336884092116,1.0542469487651,3.58515033392406,8.22614212186537,807.950983717549,1.6414741105041,1.04401171857701e-06,5.98129462653992,6.06119169154248,1899.94618136838,1.16076545932747e-08,"lineage2","dr_mutations_pyrazinamide","PRO",0,"ERR067709,1473C-sc-2011-09-07T13:20:07Z-1276556","ERR067709","lineage2.2.1","ru","Russia,Samara","pnca_p.leu172pro","A","H","LEU","LA172","pnca_complex.pdb"
|
|
"L172P","L4","PZA","L","L172",172,"P",1,"MDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",13.187,-1.353,-1.821,4.7117,-2.793,-1.44,79,85,1.192,1,1,51,0.253731343283582,"helix",0.7,4.4,0.0007187005893344,43.8,43.7999992563294,43.791882510185,32.5514826715601,14,0,0,0,0,0,0,0,0,2,2,0,0,0,0,0,0,3,4,1,-1,2,0,-2,4,-0.342705167173252,-0.470542635658915,0.17161037012216,-0.476214833759591,-0.37696335078534,0.831578947368421,0.382051282051282,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.59,1.183,"3:1","122/150","H:F:E:L:V:K:R:C:I:T:A:M:D:W",3.77963380040362,0.000336884092116,1.0542469487651,3.58515033392406,8.22614212186537,807.950983717549,1.6414741105041,1.04401171857701e-06,5.98129462653992,6.06119169154248,1899.94618136838,1.16076545932747e-08,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR1034839","ERR1034839","lineage4.8","pt","Portugal","pnca_p.leu172pro","A","H","LEU","LA172","pnca_complex.pdb"
|
|
"L172P","L2","PZA","L","L172",172,"P",NA,"XDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",13.187,-1.353,-1.821,4.7117,-2.793,-1.44,79,85,1.192,1,1,51,0.253731343283582,"helix",0.7,4.4,0.0007187005893344,43.8,43.7999992563294,43.791882510185,32.5514826715601,14,0,0,0,0,0,0,0,0,2,2,0,0,0,0,0,0,3,4,1,-1,2,0,-2,4,-0.342705167173252,-0.470542635658915,0.17161037012216,-0.476214833759591,-0.37696335078534,0.831578947368421,0.382051282051282,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.59,1.183,"3:1","122/150","H:F:E:L:V:K:R:C:I:T:A:M:D:W",3.77963380040362,0.000336884092116,1.0542469487651,3.58515033392406,8.22614212186537,807.950983717549,1.6414741105041,1.04401171857701e-06,5.98129462653992,6.06119169154248,1899.94618136838,1.16076545932747e-08,"lineage2","dr_mutations_pyrazinamide","PRO",0,"SAMN02419570","SRR1181196_SRR1159286_SRR1162517_SRR1181155","lineage2.2.1","by","Belarus","pnca_p.leu172pro","A","H","LEU","LA172","pnca_complex.pdb"
|
|
"L172P","L4","PZA","L","L172",172,"P",NA,"MDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",13.187,-1.353,-1.821,4.7117,-2.793,-1.44,79,85,1.192,1,1,51,0.253731343283582,"helix",0.7,4.4,0.0007187005893344,43.8,43.7999992563294,43.791882510185,32.5514826715601,14,0,0,0,0,0,0,0,0,2,2,0,0,0,0,0,0,3,4,1,-1,2,0,-2,4,-0.342705167173252,-0.470542635658915,0.17161037012216,-0.476214833759591,-0.37696335078534,0.831578947368421,0.382051282051282,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.59,1.183,"3:1","122/150","H:F:E:L:V:K:R:C:I:T:A:M:D:W",3.77963380040362,0.000336884092116,1.0542469487651,3.58515033392406,8.22614212186537,807.950983717549,1.6414741105041,1.04401171857701e-06,5.98129462653992,6.06119169154248,1899.94618136838,1.16076545932747e-08,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR751541","ERR751541","lineage4.3.4.1","pe","","pnca_p.leu172pro","A","H","LEU","LA172","pnca_complex.pdb"
|
|
"L172P","L4","PZA","L","L172",172,"P",NA,"MDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",13.187,-1.353,-1.821,4.7117,-2.793,-1.44,79,85,1.192,1,1,51,0.253731343283582,"helix",0.7,4.4,0.0007187005893344,43.8,43.7999992563294,43.791882510185,32.5514826715601,14,0,0,0,0,0,0,0,0,2,2,0,0,0,0,0,0,3,4,1,-1,2,0,-2,4,-0.342705167173252,-0.470542635658915,0.17161037012216,-0.476214833759591,-0.37696335078534,0.831578947368421,0.382051282051282,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.59,1.183,"3:1","122/150","H:F:E:L:V:K:R:C:I:T:A:M:D:W",3.77963380040362,0.000336884092116,1.0542469487651,3.58515033392406,8.22614212186537,807.950983717549,1.6414741105041,1.04401171857701e-06,5.98129462653992,6.06119169154248,1899.94618136838,1.16076545932747e-08,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR2510242","ERR2510242","lineage4.3.3","pe","Peru","pnca_p.leu172pro","A","H","LEU","LA172","pnca_complex.pdb"
|
|
"L172P","L2","PZA","L","L172",172,"P",1,"MDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",13.187,-1.353,-1.821,4.7117,-2.793,-1.44,79,85,1.192,1,1,51,0.253731343283582,"helix",0.7,4.4,0.0007187005893344,43.8,43.7999992563294,43.791882510185,32.5514826715601,14,0,0,0,0,0,0,0,0,2,2,0,0,0,0,0,0,3,4,1,-1,2,0,-2,4,-0.342705167173252,-0.470542635658915,0.17161037012216,-0.476214833759591,-0.37696335078534,0.831578947368421,0.382051282051282,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.59,1.183,"3:1","122/150","H:F:E:L:V:K:R:C:I:T:A:M:D:W",3.77963380040362,0.000336884092116,1.0542469487651,3.58515033392406,8.22614212186537,807.950983717549,1.6414741105041,1.04401171857701e-06,5.98129462653992,6.06119169154248,1899.94618136838,1.16076545932747e-08,"lineage2","dr_mutations_pyrazinamide","PRO",0,"ERR2516365","ERR2516365","lineage2.2.1","be","Belgium","pnca_p.leu172pro","A","H","LEU","LA172","pnca_complex.pdb"
|
|
"L172P","L2","PZA","L","L172",172,"P",NA,"XDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",13.187,-1.353,-1.821,4.7117,-2.793,-1.44,79,85,1.192,1,1,51,0.253731343283582,"helix",0.7,4.4,0.0007187005893344,43.8,43.7999992563294,43.791882510185,32.5514826715601,14,0,0,0,0,0,0,0,0,2,2,0,0,0,0,0,0,3,4,1,-1,2,0,-2,4,-0.342705167173252,-0.470542635658915,0.17161037012216,-0.476214833759591,-0.37696335078534,0.831578947368421,0.382051282051282,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.59,1.183,"3:1","122/150","H:F:E:L:V:K:R:C:I:T:A:M:D:W",3.77963380040362,0.000336884092116,1.0542469487651,3.58515033392406,8.22614212186537,807.950983717549,1.6414741105041,1.04401171857701e-06,5.98129462653992,6.06119169154248,1899.94618136838,1.16076545932747e-08,"lineage2","dr_mutations_pyrazinamide","PRO",0,"SAMN02419629","SRR1163336_SRR1174857_SRR1169129_SRR1162952","lineage2.2.1","by","Belarus","pnca_p.leu172pro","A","H","LEU","LA172","pnca_complex.pdb"
|
|
"L172P","L2","PZA","L","L172",172,"P",NA,"XDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",13.187,-1.353,-1.821,4.7117,-2.793,-1.44,79,85,1.192,1,1,51,0.253731343283582,"helix",0.7,4.4,0.0007187005893344,43.8,43.7999992563294,43.791882510185,32.5514826715601,14,0,0,0,0,0,0,0,0,2,2,0,0,0,0,0,0,3,4,1,-1,2,0,-2,4,-0.342705167173252,-0.470542635658915,0.17161037012216,-0.476214833759591,-0.37696335078534,0.831578947368421,0.382051282051282,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.59,1.183,"3:1","122/150","H:F:E:L:V:K:R:C:I:T:A:M:D:W",3.77963380040362,0.000336884092116,1.0542469487651,3.58515033392406,8.22614212186537,807.950983717549,1.6414741105041,1.04401171857701e-06,5.98129462653992,6.06119169154248,1899.94618136838,1.16076545932747e-08,"lineage2","dr_mutations_pyrazinamide","PRO",0,"SAMN02419640","SRR1169120_SRR1162978_SRR1163364_SRR1172101","lineage2.2.1","by","Belarus","pnca_p.leu172pro","A","H","LEU","LA172","pnca_complex.pdb"
|
|
"L172P","L2","PZA","L","L172",172,"P",0,"MDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",13.187,-1.353,-1.821,4.7117,-2.793,-1.44,79,85,1.192,1,1,51,0.253731343283582,"helix",0.7,4.4,0.0007187005893344,43.8,43.7999992563294,43.791882510185,32.5514826715601,14,0,0,0,0,0,0,0,0,2,2,0,0,0,0,0,0,3,4,1,-1,2,0,-2,4,-0.342705167173252,-0.470542635658915,0.17161037012216,-0.476214833759591,-0.37696335078534,0.831578947368421,0.382051282051282,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.59,1.183,"3:1","122/150","H:F:E:L:V:K:R:C:I:T:A:M:D:W",3.77963380040362,0.000336884092116,1.0542469487651,3.58515033392406,8.22614212186537,807.950983717549,1.6414741105041,1.04401171857701e-06,5.98129462653992,6.06119169154248,1899.94618136838,1.16076545932747e-08,"lineage2","dr_mutations_pyrazinamide","PRO",0,"ERR144566,1833T-sc-2012-02-21T11:37:39Z-1364803","ERR144566","lineage2.2.1","ru","Russia,Samara","pnca_p.leu172pro","A","H","LEU","LA172","pnca_complex.pdb"
|
|
"L172P","L5","PZA","L","L172",172,"P",NA,"MDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",13.187,-1.353,-1.821,4.7117,-2.793,-1.44,79,85,1.192,1,1,51,0.253731343283582,"helix",0.7,4.4,0.0007187005893344,43.8,43.7999992563294,43.791882510185,32.5514826715601,14,0,0,0,0,0,0,0,0,2,2,0,0,0,0,0,0,3,4,1,-1,2,0,-2,4,-0.342705167173252,-0.470542635658915,0.17161037012216,-0.476214833759591,-0.37696335078534,0.831578947368421,0.382051282051282,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.59,1.183,"3:1","122/150","H:F:E:L:V:K:R:C:I:T:A:M:D:W",3.77963380040362,0.000336884092116,1.0542469487651,3.58515033392406,8.22614212186537,807.950983717549,1.6414741105041,1.04401171857701e-06,5.98129462653992,6.06119169154248,1899.94618136838,1.16076545932747e-08,"lineage5","dr_mutations_pyrazinamide","PRO",0,"ERR2706928","ERR2706928","lineage5","cd","Democratic Republic of Congo","pnca_p.leu172pro","A","H","LEU","LA172","pnca_complex.pdb"
|
|
"L172P","L2","PZA","L","L172",172,"P",NA,"XDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",13.187,-1.353,-1.821,4.7117,-2.793,-1.44,79,85,1.192,1,1,51,0.253731343283582,"helix",0.7,4.4,0.0007187005893344,43.8,43.7999992563294,43.791882510185,32.5514826715601,14,0,0,0,0,0,0,0,0,2,2,0,0,0,0,0,0,3,4,1,-1,2,0,-2,4,-0.342705167173252,-0.470542635658915,0.17161037012216,-0.476214833759591,-0.37696335078534,0.831578947368421,0.382051282051282,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.59,1.183,"3:1","122/150","H:F:E:L:V:K:R:C:I:T:A:M:D:W",3.77963380040362,0.000336884092116,1.0542469487651,3.58515033392406,8.22614212186537,807.950983717549,1.6414741105041,1.04401171857701e-06,5.98129462653992,6.06119169154248,1899.94618136838,1.16076545932747e-08,"lineage2","dr_mutations_pyrazinamide","PRO",0,"SAMN02419609","SRR1163050_SRR1172155_SRR1163348_SRR1169118","lineage2.2.1","by","Belarus","pnca_p.leu172pro","A","H","LEU","LA172","pnca_complex.pdb"
|
|
"L172P","L4","PZA","L","L172",172,"P",1,"XDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",13.187,-1.353,-1.821,4.7117,-2.793,-1.44,79,85,1.192,1,1,51,0.253731343283582,"helix",0.7,4.4,0.0007187005893344,43.8,43.7999992563294,43.791882510185,32.5514826715601,14,0,0,0,0,0,0,0,0,2,2,0,0,0,0,0,0,3,4,1,-1,2,0,-2,4,-0.342705167173252,-0.470542635658915,0.17161037012216,-0.476214833759591,-0.37696335078534,0.831578947368421,0.382051282051282,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.59,1.183,"3:1","122/150","H:F:E:L:V:K:R:C:I:T:A:M:D:W",3.77963380040362,0.000336884092116,1.0542469487651,3.58515033392406,8.22614212186537,807.950983717549,1.6414741105041,1.04401171857701e-06,5.98129462653992,6.06119169154248,1899.94618136838,1.16076545932747e-08,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR2041785","ERR2041785","lineage4.2.2.1","rs","Serbia","pnca_p.leu172pro","A","H","LEU","LA172","pnca_complex.pdb"
|
|
"L172P","L2","PZA","L","L172",172,"P",NA,"XDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",13.187,-1.353,-1.821,4.7117,-2.793,-1.44,79,85,1.192,1,1,51,0.253731343283582,"helix",0.7,4.4,0.0007187005893344,43.8,43.7999992563294,43.791882510185,32.5514826715601,14,0,0,0,0,0,0,0,0,2,2,0,0,0,0,0,0,3,4,1,-1,2,0,-2,4,-0.342705167173252,-0.470542635658915,0.17161037012216,-0.476214833759591,-0.37696335078534,0.831578947368421,0.382051282051282,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.59,1.183,"3:1","122/150","H:F:E:L:V:K:R:C:I:T:A:M:D:W",3.77963380040362,0.000336884092116,1.0542469487651,3.58515033392406,8.22614212186537,807.950983717549,1.6414741105041,1.04401171857701e-06,5.98129462653992,6.06119169154248,1899.94618136838,1.16076545932747e-08,"lineage2","dr_mutations_pyrazinamide","PRO",0,"SAMN02419597","SRR1180963_SRR1159861_SRR1159986_SRR1183959","lineage2.2.1","by","Belarus","pnca_p.leu172pro","A","H","LEU","LA172","pnca_complex.pdb"
|
|
"L172P","L2","PZA","L","L172",172,"P",NA,"XDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",13.187,-1.353,-1.821,4.7117,-2.793,-1.44,79,85,1.192,1,1,51,0.253731343283582,"helix",0.7,4.4,0.0007187005893344,43.8,43.7999992563294,43.791882510185,32.5514826715601,14,0,0,0,0,0,0,0,0,2,2,0,0,0,0,0,0,3,4,1,-1,2,0,-2,4,-0.342705167173252,-0.470542635658915,0.17161037012216,-0.476214833759591,-0.37696335078534,0.831578947368421,0.382051282051282,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.59,1.183,"3:1","122/150","H:F:E:L:V:K:R:C:I:T:A:M:D:W",3.77963380040362,0.000336884092116,1.0542469487651,3.58515033392406,8.22614212186537,807.950983717549,1.6414741105041,1.04401171857701e-06,5.98129462653992,6.06119169154248,1899.94618136838,1.16076545932747e-08,"lineage2","dr_mutations_pyrazinamide","PRO",0,"SAMN02419533","SRR1181149_SRR1162529_SRR1159349_SRR1181103","lineage2.2.1","by","Belarus","pnca_p.leu172pro","A","H","LEU","LA172","pnca_complex.pdb"
|
|
"L172P","L4","PZA","L","L172",172,"P",1,"Pre-XDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",13.187,-1.353,-1.821,4.7117,-2.793,-1.44,79,85,1.192,1,1,51,0.253731343283582,"helix",0.7,4.4,0.0007187005893344,43.8,43.7999992563294,43.791882510185,32.5514826715601,14,0,0,0,0,0,0,0,0,2,2,0,0,0,0,0,0,3,4,1,-1,2,0,-2,4,-0.342705167173252,-0.470542635658915,0.17161037012216,-0.476214833759591,-0.37696335078534,0.831578947368421,0.382051282051282,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.59,1.183,"3:1","122/150","H:F:E:L:V:K:R:C:I:T:A:M:D:W",3.77963380040362,0.000336884092116,1.0542469487651,3.58515033392406,8.22614212186537,807.950983717549,1.6414741105041,1.04401171857701e-06,5.98129462653992,6.06119169154248,1899.94618136838,1.16076545932747e-08,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR2516868","ERR2516868","lineage4.2.2","gb","UK","pnca_p.leu172pro","A","H","LEU","LA172","pnca_complex.pdb"
|
|
"L172P","L4","PZA","L","L172",172,"P",NA,"MDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",13.187,-1.353,-1.821,4.7117,-2.793,-1.44,79,85,1.192,1,1,51,0.253731343283582,"helix",0.7,4.4,0.0007187005893344,43.8,43.7999992563294,43.791882510185,32.5514826715601,14,0,0,0,0,0,0,0,0,2,2,0,0,0,0,0,0,3,4,1,-1,2,0,-2,4,-0.342705167173252,-0.470542635658915,0.17161037012216,-0.476214833759591,-0.37696335078534,0.831578947368421,0.382051282051282,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.59,1.183,"3:1","122/150","H:F:E:L:V:K:R:C:I:T:A:M:D:W",3.77963380040362,0.000336884092116,1.0542469487651,3.58515033392406,8.22614212186537,807.950983717549,1.6414741105041,1.04401171857701e-06,5.98129462653992,6.06119169154248,1899.94618136838,1.16076545932747e-08,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR2515594","ERR2515594","lineage4.1.1.3","za","South Africa","pnca_p.leu172pro","A","H","LEU","LA172","pnca_complex.pdb"
|
|
"L172P","L2","PZA","L","L172",172,"P",NA,"XDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",13.187,-1.353,-1.821,4.7117,-2.793,-1.44,79,85,1.192,1,1,51,0.253731343283582,"helix",0.7,4.4,0.0007187005893344,43.8,43.7999992563294,43.791882510185,32.5514826715601,14,0,0,0,0,0,0,0,0,2,2,0,0,0,0,0,0,3,4,1,-1,2,0,-2,4,-0.342705167173252,-0.470542635658915,0.17161037012216,-0.476214833759591,-0.37696335078534,0.831578947368421,0.382051282051282,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.59,1.183,"3:1","122/150","H:F:E:L:V:K:R:C:I:T:A:M:D:W",3.77963380040362,0.000336884092116,1.0542469487651,3.58515033392406,8.22614212186537,807.950983717549,1.6414741105041,1.04401171857701e-06,5.98129462653992,6.06119169154248,1899.94618136838,1.16076545932747e-08,"lineage2","dr_mutations_pyrazinamide","PRO",0,"SAMN02419612","SRR1172238_SRR1163404_SRR1168958_SRR1163121","lineage2.2.1","by","Belarus","pnca_p.leu172pro","A","H","LEU","LA172","pnca_complex.pdb"
|
|
"L172P","L4","PZA","L","L172",172,"P",NA,"Other","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",13.187,-1.353,-1.821,4.7117,-2.793,-1.44,79,85,1.192,1,1,51,0.253731343283582,"helix",0.7,4.4,0.0007187005893344,43.8,43.7999992563294,43.791882510185,32.5514826715601,14,0,0,0,0,0,0,0,0,2,2,0,0,0,0,0,0,3,4,1,-1,2,0,-2,4,-0.342705167173252,-0.470542635658915,0.17161037012216,-0.476214833759591,-0.37696335078534,0.831578947368421,0.382051282051282,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.59,1.183,"3:1","122/150","H:F:E:L:V:K:R:C:I:T:A:M:D:W",3.77963380040362,0.000336884092116,1.0542469487651,3.58515033392406,8.22614212186537,807.950983717549,1.6414741105041,1.04401171857701e-06,5.98129462653992,6.06119169154248,1899.94618136838,1.16076545932747e-08,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR182035","ERR182035","lineage4.3.3","mw","Malawi","pnca_p.leu172pro","A","H","LEU","LA172","pnca_complex.pdb"
|
|
"L172P","L1","PZA","L","L172",172,"P",NA,"Other","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",13.187,-1.353,-1.821,4.7117,-2.793,-1.44,79,85,1.192,1,1,51,0.253731343283582,"helix",0.7,4.4,0.0007187005893344,43.8,43.7999992563294,43.791882510185,32.5514826715601,14,0,0,0,0,0,0,0,0,2,2,0,0,0,0,0,0,3,4,1,-1,2,0,-2,4,-0.342705167173252,-0.470542635658915,0.17161037012216,-0.476214833759591,-0.37696335078534,0.831578947368421,0.382051282051282,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.59,1.183,"3:1","122/150","H:F:E:L:V:K:R:C:I:T:A:M:D:W",3.77963380040362,0.000336884092116,1.0542469487651,3.58515033392406,8.22614212186537,807.950983717549,1.6414741105041,1.04401171857701e-06,5.98129462653992,6.06119169154248,1899.94618136838,1.16076545932747e-08,"lineage1","dr_mutations_pyrazinamide","PRO",0,"SRR5073726","SRR5073726","lineage1.1.1.1","vn","Vietnam","pnca_p.leu172pro","A","H","LEU","LA172","pnca_complex.pdb"
|
|
"L172P","L2","PZA","L","L172",172,"P",NA,"XDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",13.187,-1.353,-1.821,4.7117,-2.793,-1.44,79,85,1.192,1,1,51,0.253731343283582,"helix",0.7,4.4,0.0007187005893344,43.8,43.7999992563294,43.791882510185,32.5514826715601,14,0,0,0,0,0,0,0,0,2,2,0,0,0,0,0,0,3,4,1,-1,2,0,-2,4,-0.342705167173252,-0.470542635658915,0.17161037012216,-0.476214833759591,-0.37696335078534,0.831578947368421,0.382051282051282,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.59,1.183,"3:1","122/150","H:F:E:L:V:K:R:C:I:T:A:M:D:W",3.77963380040362,0.000336884092116,1.0542469487651,3.58515033392406,8.22614212186537,807.950983717549,1.6414741105041,1.04401171857701e-06,5.98129462653992,6.06119169154248,1899.94618136838,1.16076545932747e-08,"lineage2","dr_mutations_pyrazinamide","PRO",0,"SAMN02419558","SRR1159066_SRR1181093_SRR1162530_SRR1181152","lineage2.2.1","by","Belarus","pnca_p.leu172pro","A","H","LEU","LA172","pnca_complex.pdb"
|
|
"L172P","L2","PZA","L","L172",172,"P",NA,"XDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",13.187,-1.353,-1.821,4.7117,-2.793,-1.44,79,85,1.192,1,1,51,0.253731343283582,"helix",0.7,4.4,0.0007187005893344,43.8,43.7999992563294,43.791882510185,32.5514826715601,14,0,0,0,0,0,0,0,0,2,2,0,0,0,0,0,0,3,4,1,-1,2,0,-2,4,-0.342705167173252,-0.470542635658915,0.17161037012216,-0.476214833759591,-0.37696335078534,0.831578947368421,0.382051282051282,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.59,1.183,"3:1","122/150","H:F:E:L:V:K:R:C:I:T:A:M:D:W",3.77963380040362,0.000336884092116,1.0542469487651,3.58515033392406,8.22614212186537,807.950983717549,1.6414741105041,1.04401171857701e-06,5.98129462653992,6.06119169154248,1899.94618136838,1.16076545932747e-08,"lineage2","dr_mutations_pyrazinamide","PRO",0,"SAMN02419590","SRR1180923_SRR1159294_SRR1159384_SRR1181080","lineage2.2.1","by","Belarus","pnca_p.leu172pro","A","H","LEU","LA172","pnca_complex.pdb"
|
|
"L172P","L2","PZA","L","L172",172,"P",NA,"XDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",13.187,-1.353,-1.821,4.7117,-2.793,-1.44,79,85,1.192,1,1,51,0.253731343283582,"helix",0.7,4.4,0.0007187005893344,43.8,43.7999992563294,43.791882510185,32.5514826715601,14,0,0,0,0,0,0,0,0,2,2,0,0,0,0,0,0,3,4,1,-1,2,0,-2,4,-0.342705167173252,-0.470542635658915,0.17161037012216,-0.476214833759591,-0.37696335078534,0.831578947368421,0.382051282051282,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.59,1.183,"3:1","122/150","H:F:E:L:V:K:R:C:I:T:A:M:D:W",3.77963380040362,0.000336884092116,1.0542469487651,3.58515033392406,8.22614212186537,807.950983717549,1.6414741105041,1.04401171857701e-06,5.98129462653992,6.06119169154248,1899.94618136838,1.16076545932747e-08,"lineage2","dr_mutations_pyrazinamide","PRO",0,"SAMN02419628","SRR1163101_SRR1169027_SRR1172368_SRR1163313","lineage2.2.1","by","Belarus","pnca_p.leu172pro","A","H","LEU","LA172","pnca_complex.pdb"
|
|
"L172P","L4","PZA","L","L172",172,"P",1,"MDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",13.187,-1.353,-1.821,4.7117,-2.793,-1.44,79,85,1.192,1,1,51,0.253731343283582,"helix",0.7,4.4,0.0007187005893344,43.8,43.7999992563294,43.791882510185,32.5514826715601,14,0,0,0,0,0,0,0,0,2,2,0,0,0,0,0,0,3,4,1,-1,2,0,-2,4,-0.342705167173252,-0.470542635658915,0.17161037012216,-0.476214833759591,-0.37696335078534,0.831578947368421,0.382051282051282,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.59,1.183,"3:1","122/150","H:F:E:L:V:K:R:C:I:T:A:M:D:W",3.77963380040362,0.000336884092116,1.0542469487651,3.58515033392406,8.22614212186537,807.950983717549,1.6414741105041,1.04401171857701e-06,5.98129462653992,6.06119169154248,1899.94618136838,1.16076545932747e-08,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR1034811","ERR1034811","lineage4.8","pt","Portugal","pnca_p.leu172pro","A","H","LEU","LA172","pnca_complex.pdb"
|
|
"L172P","L4","PZA","L","L172",172,"P",NA,"MDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",13.187,-1.353,-1.821,4.7117,-2.793,-1.44,79,85,1.192,1,1,51,0.253731343283582,"helix",0.7,4.4,0.0007187005893344,43.8,43.7999992563294,43.791882510185,32.5514826715601,14,0,0,0,0,0,0,0,0,2,2,0,0,0,0,0,0,3,4,1,-1,2,0,-2,4,-0.342705167173252,-0.470542635658915,0.17161037012216,-0.476214833759591,-0.37696335078534,0.831578947368421,0.382051282051282,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.59,1.183,"3:1","122/150","H:F:E:L:V:K:R:C:I:T:A:M:D:W",3.77963380040362,0.000336884092116,1.0542469487651,3.58515033392406,8.22614212186537,807.950983717549,1.6414741105041,1.04401171857701e-06,5.98129462653992,6.06119169154248,1899.94618136838,1.16076545932747e-08,"lineage4","dr_mutations_pyrazinamide","PRO",0,"SRR3725719","SRR3725719","lineage4.1","ci","Ivory_Coast","pnca_p.leu172pro","A","H","LEU","LA172","pnca_complex.pdb"
|
|
"L172P","L4","PZA","L","L172",172,"P",1,"MDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",13.187,-1.353,-1.821,4.7117,-2.793,-1.44,79,85,1.192,1,1,51,0.253731343283582,"helix",0.7,4.4,0.0007187005893344,43.8,43.7999992563294,43.791882510185,32.5514826715601,14,0,0,0,0,0,0,0,0,2,2,0,0,0,0,0,0,3,4,1,-1,2,0,-2,4,-0.342705167173252,-0.470542635658915,0.17161037012216,-0.476214833759591,-0.37696335078534,0.831578947368421,0.382051282051282,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.59,1.183,"3:1","122/150","H:F:E:L:V:K:R:C:I:T:A:M:D:W",3.77963380040362,0.000336884092116,1.0542469487651,3.58515033392406,8.22614212186537,807.950983717549,1.6414741105041,1.04401171857701e-06,5.98129462653992,6.06119169154248,1899.94618136838,1.16076545932747e-08,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERR2041802","ERR2041802","lineage4.8","rs","Serbia","pnca_p.leu172pro","A","H","LEU","LA172","pnca_complex.pdb"
|
|
"L172P","L4","PZA","L","L172",172,"P",1,"MDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",13.187,-1.353,-1.821,4.7117,-2.793,-1.44,79,85,1.192,1,1,51,0.253731343283582,"helix",0.7,4.4,0.0007187005893344,43.8,43.7999992563294,43.791882510185,32.5514826715601,14,0,0,0,0,0,0,0,0,2,2,0,0,0,0,0,0,3,4,1,-1,2,0,-2,4,-0.342705167173252,-0.470542635658915,0.17161037012216,-0.476214833759591,-0.37696335078534,0.831578947368421,0.382051282051282,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.59,1.183,"3:1","122/150","H:F:E:L:V:K:R:C:I:T:A:M:D:W",3.77963380040362,0.000336884092116,1.0542469487651,3.58515033392406,8.22614212186537,807.950983717549,1.6414741105041,1.04401171857701e-06,5.98129462653992,6.06119169154248,1899.94618136838,1.16076545932747e-08,"lineage4","dr_mutations_pyrazinamide","PRO",0,"ERS456778,ERR550665,1599-04","ERR550665","lineage4.1.2.1","","","pnca_p.leu172pro","A","H","LEU","LA172","pnca_complex.pdb"
|
|
"L172P","L2","PZA","L","L172",172,"P",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",13.187,-1.353,-1.821,4.7117,-2.793,-1.44,79,85,1.192,1,1,51,0.253731343283582,"helix",0.7,4.4,0.0007187005893344,43.8,43.7999992563294,43.791882510185,32.5514826715601,14,0,0,0,0,0,0,0,0,2,2,0,0,0,0,0,0,3,4,1,-1,2,0,-2,4,-0.342705167173252,-0.470542635658915,0.17161037012216,-0.476214833759591,-0.37696335078534,0.831578947368421,0.382051282051282,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.59,1.183,"3:1","122/150","H:F:E:L:V:K:R:C:I:T:A:M:D:W",3.77963380040362,0.000336884092116,1.0542469487651,3.58515033392406,8.22614212186537,807.950983717549,1.6414741105041,1.04401171857701e-06,5.98129462653992,6.06119169154248,1899.94618136838,1.16076545932747e-08,"lineage2","dr_mutations_pyrazinamide","PRO",0,"SAMN02419588","SRR1159389_SRR1184125_SRR1159262_SRR1180976","lineage2.2.1","by","Belarus","pnca_p.leu172pro","A","H","LEU","LA172","pnca_complex.pdb"
|
|
"L172P","L2","PZA","L","L172",172,"P",NA,"XDR","DM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",13.187,-1.353,-1.821,4.7117,-2.793,-1.44,79,85,1.192,1,1,51,0.253731343283582,"helix",0.7,4.4,0.0007187005893344,43.8,43.7999992563294,43.791882510185,32.5514826715601,14,0,0,0,0,0,0,0,0,2,2,0,0,0,0,0,0,3,4,1,-1,2,0,-2,4,-0.342705167173252,-0.470542635658915,0.17161037012216,-0.476214833759591,-0.37696335078534,0.831578947368421,0.382051282051282,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",0.59,1.183,"3:1","122/150","H:F:E:L:V:K:R:C:I:T:A:M:D:W",3.77963380040362,0.000336884092116,1.0542469487651,3.58515033392406,8.22614212186537,807.950983717549,1.6414741105041,1.04401171857701e-06,5.98129462653992,6.06119169154248,1899.94618136838,1.16076545932747e-08,"lineage2","dr_mutations_pyrazinamide","PRO",0,"SAMN02419569","SRR1158898_SRR1184036_SRR1181025_SRR1162541","lineage2.2.1","by","Belarus","pnca_p.leu172pro","A","H","LEU","LA172","pnca_complex.pdb"
|
|
"L172R","L4","PZA","L","L172",172,"R",NA,"MDR","DM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",13.187,-0.704,-0.848,-0.385063,-1.797,-0.43,33,66,1.192,1,1,51,0.253731343283582,"helix",0.7,4.4,0.0001437401178668,19.411022297013,511754.463552565,Inf,4.73122070382274,-32,-36,0,-2,-34,0,0,0,0,-2,0,0,-4,0,0,0,0,-8,0,-1,-6,-8,0,-8,0,-0.178318135764944,-0.219121447028424,-0.0740334922710144,-0.306393861892583,-0.112565445026178,0.347368421052632,0.382051282051282,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",0.59,1.183,"3:1","122/150","H:F:E:L:V:K:R:C:I:T:A:M:D:W",13.1456002256205,0.924803768446996,139.277183326561,0.0943844491369283,0.0001628371344453,NA,1.28804840845689,0.0292235860951597,1.53426649183163,0.91081598550184,Inf,0.0296198560706035,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERR1035063","ERR1035063","lineage4.3.2.1","za","South Africa","pnca_p.leu172arg","A","H","LEU","LA172","pnca_complex.pdb"
|
|
"L172R","L4","PZA","L","L172",172,"R",NA,"MDR","DM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",13.187,-0.704,-0.848,-0.385063,-1.797,-0.43,33,66,1.192,1,1,51,0.253731343283582,"helix",0.7,4.4,0.0001437401178668,19.411022297013,511754.463552565,Inf,4.73122070382274,-32,-36,0,-2,-34,0,0,0,0,-2,0,0,-4,0,0,0,0,-8,0,-1,-6,-8,0,-8,0,-0.178318135764944,-0.219121447028424,-0.0740334922710144,-0.306393861892583,-0.112565445026178,0.347368421052632,0.382051282051282,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",0.59,1.183,"3:1","122/150","H:F:E:L:V:K:R:C:I:T:A:M:D:W",13.1456002256205,0.924803768446996,139.277183326561,0.0943844491369283,0.0001628371344453,NA,1.28804840845689,0.0292235860951597,1.53426649183163,0.91081598550184,Inf,0.0296198560706035,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERR2516344","ERR2516344","lineage4.1","be","Belgium","pnca_p.leu172arg","A","H","LEU","LA172","pnca_complex.pdb"
|
|
"L172R","L4","PZA","L","L172",172,"R",NA,"MDR","DM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",13.187,-0.704,-0.848,-0.385063,-1.797,-0.43,33,66,1.192,1,1,51,0.253731343283582,"helix",0.7,4.4,0.0001437401178668,19.411022297013,511754.463552565,Inf,4.73122070382274,-32,-36,0,-2,-34,0,0,0,0,-2,0,0,-4,0,0,0,0,-8,0,-1,-6,-8,0,-8,0,-0.178318135764944,-0.219121447028424,-0.0740334922710144,-0.306393861892583,-0.112565445026178,0.347368421052632,0.382051282051282,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",0.59,1.183,"3:1","122/150","H:F:E:L:V:K:R:C:I:T:A:M:D:W",13.1456002256205,0.924803768446996,139.277183326561,0.0943844491369283,0.0001628371344453,NA,1.28804840845689,0.0292235860951597,1.53426649183163,0.91081598550184,Inf,0.0296198560706035,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERR2679269","ERR2679269","lineage4.1","","","pnca_p.leu172arg","A","H","LEU","LA172","pnca_complex.pdb"
|
|
"L172R","L4","PZA","L","L172",172,"R",1,"MDR","DM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",13.187,-0.704,-0.848,-0.385063,-1.797,-0.43,33,66,1.192,1,1,51,0.253731343283582,"helix",0.7,4.4,0.0001437401178668,19.411022297013,511754.463552565,Inf,4.73122070382274,-32,-36,0,-2,-34,0,0,0,0,-2,0,0,-4,0,0,0,0,-8,0,-1,-6,-8,0,-8,0,-0.178318135764944,-0.219121447028424,-0.0740334922710144,-0.306393861892583,-0.112565445026178,0.347368421052632,0.382051282051282,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",0.59,1.183,"3:1","122/150","H:F:E:L:V:K:R:C:I:T:A:M:D:W",13.1456002256205,0.924803768446996,139.277183326561,0.0943844491369283,0.0001628371344453,NA,1.28804840845689,0.0292235860951597,1.53426649183163,0.91081598550184,Inf,0.0296198560706035,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERR2515664","ERR2515664","lineage4.3.2.1","za","South Africa","pnca_p.leu172arg","A","H","LEU","LA172","pnca_complex.pdb"
|
|
"L172R","L4","PZA","L","L172",172,"R",1,"MDR","DM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",13.187,-0.704,-0.848,-0.385063,-1.797,-0.43,33,66,1.192,1,1,51,0.253731343283582,"helix",0.7,4.4,0.0001437401178668,19.411022297013,511754.463552565,Inf,4.73122070382274,-32,-36,0,-2,-34,0,0,0,0,-2,0,0,-4,0,0,0,0,-8,0,-1,-6,-8,0,-8,0,-0.178318135764944,-0.219121447028424,-0.0740334922710144,-0.306393861892583,-0.112565445026178,0.347368421052632,0.382051282051282,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",0.59,1.183,"3:1","122/150","H:F:E:L:V:K:R:C:I:T:A:M:D:W",13.1456002256205,0.924803768446996,139.277183326561,0.0943844491369283,0.0001628371344453,NA,1.28804840845689,0.0292235860951597,1.53426649183163,0.91081598550184,Inf,0.0296198560706035,"lineage4","dr_mutations_pyrazinamide","ARG",0,"ERR2516255","ERR2516255","lineage4.1","be","Belgium","pnca_p.leu172arg","A","H","LEU","LA172","pnca_complex.pdb"
|
|
"E173G","L4","PZA","E","E173",173,"G",NA,"Sensitive","OM","hydrophilic","hydrophobic","acidic","neutral","neg","non-polar",15.936,-0.78,-1.172,0.769667,-0.869,-1.04,-5,53,1.516,1,1,114,0.511210762331839,"helix",-1.06666666666667,3.82,NA,NA,NA,NA,NA,6,18,0,0,18,0,0,0,0,0,0,0,0,0,0,0,0,3,0,3,1,0,0,3,13,-0.197568389057751,-0.302842377260982,0.0280329475010745,-0.148167092924126,-0.272251308900524,-0.0537634408602151,0.485897435897436,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","neutral",0.842,1.712,"2:1","122/150","Q:E:F:H:K:R:L:V:S:M:G:A:T:D",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage4","other_mutations_pyrazinamide","GLY",0,"ERR126622","ERR126622","lineage4.3.4.2.1","mw","Malawi","pnca_p.glu173gly","A","H","GLU","EA173","pnca_complex.pdb"
|
|
"E173G","L1;L4","PZA","E","E173",173,"G",NA,"Sensitive","OM","hydrophilic","hydrophobic","acidic","neutral","neg","non-polar",15.936,-0.78,-1.172,0.769667,-0.869,-1.04,-5,53,1.516,1,1,114,0.511210762331839,"helix",-1.06666666666667,3.82,NA,NA,NA,NA,NA,6,18,0,0,18,0,0,0,0,0,0,0,0,0,0,0,0,3,0,3,1,0,0,3,13,-0.197568389057751,-0.302842377260982,0.0280329475010745,-0.148167092924126,-0.272251308900524,-0.0537634408602151,0.485897435897436,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","neutral",0.842,1.712,"2:1","122/150","Q:E:F:H:K:R:L:V:S:M:G:A:T:D",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage1;lineage4","other_mutations_pyrazinamide","GLY",0,"ERR163943","ERR163943","lineage4.3.4.2.1;lineage1","mw","Malawi","pnca_p.glu173gly","A","H","GLU","EA173","pnca_complex.pdb"
|
|
"E173G","L4","PZA","E","E173",173,"G",NA,"Sensitive","OM","hydrophilic","hydrophobic","acidic","neutral","neg","non-polar",15.936,-0.78,-1.172,0.769667,-0.869,-1.04,-5,53,1.516,1,1,114,0.511210762331839,"helix",-1.06666666666667,3.82,NA,NA,NA,NA,NA,6,18,0,0,18,0,0,0,0,0,0,0,0,0,0,0,0,3,0,3,1,0,0,3,13,-0.197568389057751,-0.302842377260982,0.0280329475010745,-0.148167092924126,-0.272251308900524,-0.0537634408602151,0.485897435897436,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","neutral",0.842,1.712,"2:1","122/150","Q:E:F:H:K:R:L:V:S:M:G:A:T:D",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage4","other_mutations_pyrazinamide","GLY",0,"ERR181839","ERR181839","lineage4.3.4.2.1","mw","Malawi","pnca_p.glu173gly","A","H","GLU","EA173","pnca_complex.pdb"
|
|
"E173G","L4","PZA","E","E173",173,"G",NA,"Sensitive","OM","hydrophilic","hydrophobic","acidic","neutral","neg","non-polar",15.936,-0.78,-1.172,0.769667,-0.869,-1.04,-5,53,1.516,1,1,114,0.511210762331839,"helix",-1.06666666666667,3.82,NA,NA,NA,NA,NA,6,18,0,0,18,0,0,0,0,0,0,0,0,0,0,0,0,3,0,3,1,0,0,3,13,-0.197568389057751,-0.302842377260982,0.0280329475010745,-0.148167092924126,-0.272251308900524,-0.0537634408602151,0.485897435897436,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","neutral",0.842,1.712,"2:1","122/150","Q:E:F:H:K:R:L:V:S:M:G:A:T:D",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage4","other_mutations_pyrazinamide","GLY",0,"ERR212141","ERR212141","lineage4.3.4.2.1","mw","Malawi","pnca_p.glu173gly","A","H","GLU","EA173","pnca_complex.pdb"
|
|
"E174D","L2","PZA","E","E174",174,"D",1,"MDR","OM","hydrophilic","hydrophilic","acidic","acidic","neg","neg",14.835,-0.016,-0.698,0.557649,-0.445,-0.43,-14,57,-0.292,6,6,104,0.466367713004484,"helix",-1.7,3.93,7.18700589334483e-05,9.70142977291842,188179.926264691,Inf,0.763784339928386,14,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,-0.0040526849037487,-0.180361757105943,0.0203107904340795,-0.0758738277919864,-0.112565445026178,-0.150537634408602,-0.240527182866557,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","neutral",-0.485,-0.147,"7:6","122/150","D:T:A:G:S:K:R:Q:E",12.1451538387268,0.919026337424243,119.468044436249,0.101660271548244,5.01153666061119e-06,NA,0.986835744238421,0.170978870202674,0.767057556984365,0.124324963210678,Inf,0.382146811758261,"lineage2","other_mutations_pyrazinamide","ASP",0,"ERS2592796","ERR2677451","lineage2.2.1","de","Germany","pnca_p.glu174asp","A","H","GLU","EA174","pnca_complex.pdb"
|
|
"E174G","L2","PZA","E","E174",174,"G",0,"MDR","DM","hydrophilic","hydrophobic","acidic","neutral","neg","non-polar",14.835,-1.181,-0.868,0.834042,-0.968,-0.01,54,75,-0.292,6,6,104,0.466367713004484,"helix",-1.7,3.93,0.0001437401178668,1.2119588062211,4.59700131334288e-05,0,1.01056822389159e-25,22,22,0,0,22,0,0,0,0,0,0,0,0,0,0,0,0,2,0,2,0,0,0,3,15,-0.299138804457953,-0.224289405684755,0.0303776251283882,-0.165046888320546,-0.0026178010471204,0.568421052631579,-0.240527182866557,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.485,-0.147,"7:6","122/150","D:T:A:G:S:K:R:Q:E",-9.98752126245053,0.942832958100734,139.277183325396,-0.0717096729269466,NA,144471.706314838,0.0834878586628579,1,0,0,25.8386585962163,0.999999999999746,"lineage2","dr_mutations_pyrazinamide","GLY",0,"MDR_11151","SRR6824687","lineage2.2.1","cn","China: Luqiao District, Taizhou City, Zhejiang Province","pnca_p.glu174gly","A","H","GLU","EA174","pnca_complex.pdb"
|
|
"E174G","L4","PZA","E","E174",174,"G",0,"Other","DM","hydrophilic","hydrophobic","acidic","neutral","neg","non-polar",14.835,-1.181,-0.868,0.834042,-0.968,-0.01,54,75,-0.292,6,6,104,0.466367713004484,"helix",-1.7,3.93,0.0001437401178668,1.2119588062211,4.59700131334288e-05,0,1.01056822389159e-25,22,22,0,0,22,0,0,0,0,0,0,0,0,0,0,0,0,2,0,2,0,0,0,3,15,-0.299138804457953,-0.224289405684755,0.0303776251283882,-0.165046888320546,-0.0026178010471204,0.568421052631579,-0.240527182866557,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.485,-0.147,"7:6","122/150","D:T:A:G:S:K:R:Q:E",-9.98752126245053,0.942832958100734,139.277183325396,-0.0717096729269466,NA,144471.706314838,0.0834878586628579,1,0,0,25.8386585962163,0.999999999999746,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR2515154","ERR2515154","lineage4.1.1.3","za","South Africa","pnca_p.glu174gly","A","H","GLU","EA174","pnca_complex.pdb"
|
|
"E174G","L2","PZA","E","E174",174,"G",NA,"MDR","DM","hydrophilic","hydrophobic","acidic","neutral","neg","non-polar",14.835,-1.181,-0.868,0.834042,-0.968,-0.01,54,75,-0.292,6,6,104,0.466367713004484,"helix",-1.7,3.93,0.0001437401178668,1.2119588062211,4.59700131334288e-05,0,1.01056822389159e-25,22,22,0,0,22,0,0,0,0,0,0,0,0,0,0,0,0,2,0,2,0,0,0,3,15,-0.299138804457953,-0.224289405684755,0.0303776251283882,-0.165046888320546,-0.0026178010471204,0.568421052631579,-0.240527182866557,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.485,-0.147,"7:6","122/150","D:T:A:G:S:K:R:Q:E",-9.98752126245053,0.942832958100734,139.277183325396,-0.0717096729269466,NA,144471.706314838,0.0834878586628579,1,0,0,25.8386585962163,0.999999999999746,"lineage2","dr_mutations_pyrazinamide","GLY",0,"SRS797209","SRR1723730","lineage2.2.1","cn","China:Zhejiang","pnca_p.glu174gly","A","H","GLU","EA174","pnca_complex.pdb"
|
|
"E174K","L1","PZA","E","E174",174,"K",NA,"Sensitive","OM","hydrophilic","hydrophobic","acidic","basic","neg","pos",14.835,-0.819,0.204,-0.813418,-0.452,-0.16,26,63,-0.292,6,6,104,0.466367713004484,"helix",-1.7,3.93,NA,NA,NA,NA,NA,-6,4,0,0,4,0,0,0,0,0,0,2,-2,0,0,0,0,0,0,0,-1,0,0,0,0,-0.207446808510638,0.173469387755102,-0.156390448358071,-0.0770673486786019,-0.0418848167539267,0.273684210526316,-0.240527182866557,"Destabilising","Stabilising","Stabilising","Destabilising","Destabilising","effect",-0.485,-0.147,"7:6","122/150","D:T:A:G:S:K:R:Q:E",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage1","other_mutations_pyrazinamide","LYS",0,"SRR5067256","SRR5067256","lineage1.1.1","vn","Vietnam","pnca_p.glu174lys","A","H","GLU","EA174","pnca_complex.pdb"
|
|
"E174K","L1","PZA","E","E174",174,"K",NA,"Sensitive","OM","hydrophilic","hydrophobic","acidic","basic","neg","pos",14.835,-0.819,0.204,-0.813418,-0.452,-0.16,26,63,-0.292,6,6,104,0.466367713004484,"helix",-1.7,3.93,NA,NA,NA,NA,NA,-6,4,0,0,4,0,0,0,0,0,0,2,-2,0,0,0,0,0,0,0,-1,0,0,0,0,-0.207446808510638,0.173469387755102,-0.156390448358071,-0.0770673486786019,-0.0418848167539267,0.273684210526316,-0.240527182866557,"Destabilising","Stabilising","Stabilising","Destabilising","Destabilising","effect",-0.485,-0.147,"7:6","122/150","D:T:A:G:S:K:R:Q:E",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage1","other_mutations_pyrazinamide","LYS",0,"SRR5067397","SRR5067397","lineage1.1.1","vn","Vietnam","pnca_p.glu174lys","A","H","GLU","EA174","pnca_complex.pdb"
|
|
"M175I","L2","PZA","M","M175",175,"I",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",11.016,-1.143,-0.676,1.67797,-1.272,-0.65,19,59,-0.521,7,7,0,0,"helix",-2.03333333333333,6.81,0.0002874802357337,1.61648444070648,1.61648999729673,1.61641362774286,5.75148528770432e-25,14,2,0,0,2,0,0,0,0,0,0,0,0,0,0,0,0,-5,0,-1,-4,6,0,4,4,-0.28951367781155,-0.174677002583979,0.0611153198959783,-0.216879795396419,-0.170157068062827,0.2,-0.429159802306425,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.674,-0.411,"7:7","120/150","F:M:I:W:C:L:V",0.480257130287143,0.677247786834333,1.1538493489906,0.416221693678881,0.0799389646162787,12.6318165284426,0.208571528713835,0.527693668101443,0.277618116975238,0.0307788891197694,20.1401594005,0.999999999999395,"lineage2","dr_mutations_pyrazinamide","ILE",0,"ERR2516249","ERR2516249","lineage2.2.1","be","Belgium","pnca_p.met175ile","A","H","MET","MA175","pnca_complex.pdb"
|
|
"M175I","L1","PZA","M","M175",175,"I",0,"MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",11.016,-1.143,-0.676,1.67797,-1.272,-0.65,19,59,-0.521,7,7,0,0,"helix",-2.03333333333333,6.81,0.0002874802357337,1.61648444070648,1.61648999729673,1.61641362774286,5.75148528770432e-25,14,2,0,0,2,0,0,0,0,0,0,0,0,0,0,0,0,-5,0,-1,-4,6,0,4,4,-0.28951367781155,-0.174677002583979,0.0611153198959783,-0.216879795396419,-0.170157068062827,0.2,-0.429159802306425,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.674,-0.411,"7:7","120/150","F:M:I:W:C:L:V",0.480257130287143,0.677247786834333,1.1538493489906,0.416221693678881,0.0799389646162787,12.6318165284426,0.208571528713835,0.527693668101443,0.277618116975238,0.0307788891197694,20.1401594005,0.999999999999395,"lineage1","dr_mutations_pyrazinamide","ILE",0,"ERR2516786","ERR2516786","lineage1.1.2","gb","UK","pnca_p.met175ile","A","H","MET","MA175","pnca_complex.pdb"
|
|
"M175I","L4","PZA","M","M175",175,"I",0,"MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",11.016,-1.143,-0.676,1.67797,-1.272,-0.65,19,59,-0.521,7,7,0,0,"helix",-2.03333333333333,6.81,0.0002874802357337,1.61648444070648,1.61648999729673,1.61641362774286,5.75148528770432e-25,14,2,0,0,2,0,0,0,0,0,0,0,0,0,0,0,0,-5,0,-1,-4,6,0,4,4,-0.28951367781155,-0.174677002583979,0.0611153198959783,-0.216879795396419,-0.170157068062827,0.2,-0.429159802306425,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.674,-0.411,"7:7","120/150","F:M:I:W:C:L:V",0.480257130287143,0.677247786834333,1.1538493489906,0.416221693678881,0.0799389646162787,12.6318165284426,0.208571528713835,0.527693668101443,0.277618116975238,0.0307788891197694,20.1401594005,0.999999999999395,"lineage4","dr_mutations_pyrazinamide","ILE",0,"ERR2516811","ERR2516811","lineage4.2.1","gb","UK","pnca_p.met175ile","A","H","MET","MA175","pnca_complex.pdb"
|
|
"M175I","L2","PZA","M","M175",175,"I",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",11.016,-1.143,-0.676,1.67797,-1.272,-0.65,19,59,-0.521,7,7,0,0,"helix",-2.03333333333333,6.81,0.0002874802357337,1.61648444070648,1.61648999729673,1.61641362774286,5.75148528770432e-25,14,2,0,0,2,0,0,0,0,0,0,0,0,0,0,0,0,-5,0,-1,-4,6,0,4,4,-0.28951367781155,-0.174677002583979,0.0611153198959783,-0.216879795396419,-0.170157068062827,0.2,-0.429159802306425,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.674,-0.411,"7:7","120/150","F:M:I:W:C:L:V",0.480257130287143,0.677247786834333,1.1538493489906,0.416221693678881,0.0799389646162787,12.6318165284426,0.208571528713835,0.527693668101443,0.277618116975238,0.0307788891197694,20.1401594005,0.999999999999395,"lineage2","dr_mutations_pyrazinamide","ILE",0,"SRS797277","SRR1723803","lineage2.2.1","cn","China:Sichuan","pnca_p.met175ile","A","H","MET","MA175","pnca_complex.pdb"
|
|
"M175I","L4","PZA","M","M175",175,"I",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",11.016,-1.143,-0.676,1.67797,-1.272,-0.65,19,59,-0.521,7,7,0,0,"helix",-2.03333333333333,6.81,0.0002874802357337,1.61648444070648,1.61648999729673,1.61641362774286,5.75148528770432e-25,14,2,0,0,2,0,0,0,0,0,0,0,0,0,0,0,0,-5,0,-1,-4,6,0,4,4,-0.28951367781155,-0.174677002583979,0.0611153198959783,-0.216879795396419,-0.170157068062827,0.2,-0.429159802306425,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.674,-0.411,"7:7","120/150","F:M:I:W:C:L:V",0.480257130287143,0.677247786834333,1.1538493489906,0.416221693678881,0.0799389646162787,12.6318165284426,0.208571528713835,0.527693668101443,0.277618116975238,0.0307788891197694,20.1401594005,0.999999999999395,"lineage4","dr_mutations_pyrazinamide","ILE",0,"ERR2516232","ERR2516232","lineage4.6.1.2","be","Belgium","pnca_p.met175ile","A","H","MET","MA175","pnca_complex.pdb"
|
|
"M175I","L4","PZA","M","M175",175,"I",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",11.016,-1.143,-0.676,1.67797,-1.272,-0.65,19,59,-0.521,7,7,0,0,"helix",-2.03333333333333,6.81,0.0002874802357337,1.61648444070648,1.61648999729673,1.61641362774286,5.75148528770432e-25,14,2,0,0,2,0,0,0,0,0,0,0,0,0,0,0,0,-5,0,-1,-4,6,0,4,4,-0.28951367781155,-0.174677002583979,0.0611153198959783,-0.216879795396419,-0.170157068062827,0.2,-0.429159802306425,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.674,-0.411,"7:7","120/150","F:M:I:W:C:L:V",0.480257130287143,0.677247786834333,1.1538493489906,0.416221693678881,0.0799389646162787,12.6318165284426,0.208571528713835,0.527693668101443,0.277618116975238,0.0307788891197694,20.1401594005,0.999999999999395,"lineage4","dr_mutations_pyrazinamide","ILE",0,"ERR2516720","ERR2516720","lineage4.6.1.2","nl","Netherlands","pnca_p.met175ile","A","H","MET","MA175","pnca_complex.pdb"
|
|
"M175I","L4","PZA","M","M175",175,"I",0,"MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",11.016,-1.143,-0.676,1.67797,-1.272,-0.65,19,59,-0.521,7,7,0,0,"helix",-2.03333333333333,6.81,0.0002874802357337,1.61648444070648,1.61648999729673,1.61641362774286,5.75148528770432e-25,14,2,0,0,2,0,0,0,0,0,0,0,0,0,0,0,0,-5,0,-1,-4,6,0,4,4,-0.28951367781155,-0.174677002583979,0.0611153198959783,-0.216879795396419,-0.170157068062827,0.2,-0.429159802306425,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.674,-0.411,"7:7","120/150","F:M:I:W:C:L:V",0.480257130287143,0.677247786834333,1.1538493489906,0.416221693678881,0.0799389646162787,12.6318165284426,0.208571528713835,0.527693668101443,0.277618116975238,0.0307788891197694,20.1401594005,0.999999999999395,"lineage4","dr_mutations_pyrazinamide","ILE",0,"ERR040131","ERR040131","lineage4.6.1.2","ug","Uganda","pnca_p.met175ile","A","H","MET","MA175","pnca_complex.pdb"
|
|
"M175I","L2","PZA","M","M175",175,"I",1,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",11.016,-1.143,-0.676,1.67797,-1.272,-0.65,19,59,-0.521,7,7,0,0,"helix",-2.03333333333333,6.81,0.0002874802357337,1.61648444070648,1.61648999729673,1.61641362774286,5.75148528770432e-25,14,2,0,0,2,0,0,0,0,0,0,0,0,0,0,0,0,-5,0,-1,-4,6,0,4,4,-0.28951367781155,-0.174677002583979,0.0611153198959783,-0.216879795396419,-0.170157068062827,0.2,-0.429159802306425,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.674,-0.411,"7:7","120/150","F:M:I:W:C:L:V",0.480257130287143,0.677247786834333,1.1538493489906,0.416221693678881,0.0799389646162787,12.6318165284426,0.208571528713835,0.527693668101443,0.277618116975238,0.0307788891197694,20.1401594005,0.999999999999395,"lineage2","dr_mutations_pyrazinamide","ILE",0,"MDR_23557","SRR6824483","lineage2.2.1","cn","China: Jiangyou City, Mianyang City, Sichuan Province","pnca_p.met175ile","A","H","MET","MA175","pnca_complex.pdb"
|
|
"M175I","L2","PZA","M","M175",175,"I",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",11.016,-1.143,-0.676,1.67797,-1.272,-0.65,19,59,-0.521,7,7,0,0,"helix",-2.03333333333333,6.81,0.0002874802357337,1.61648444070648,1.61648999729673,1.61641362774286,5.75148528770432e-25,14,2,0,0,2,0,0,0,0,0,0,0,0,0,0,0,0,-5,0,-1,-4,6,0,4,4,-0.28951367781155,-0.174677002583979,0.0611153198959783,-0.216879795396419,-0.170157068062827,0.2,-0.429159802306425,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.674,-0.411,"7:7","120/150","F:M:I:W:C:L:V",0.480257130287143,0.677247786834333,1.1538493489906,0.416221693678881,0.0799389646162787,12.6318165284426,0.208571528713835,0.527693668101443,0.277618116975238,0.0307788891197694,20.1401594005,0.999999999999395,"lineage2","dr_mutations_pyrazinamide","ILE",0,"SRS935985,SAMN03653250","SRR2024947","lineage2.2.1","cn","China","pnca_p.met175ile","A","H","MET","MA175","pnca_complex.pdb"
|
|
"M175K","L4","PZA","M","M175",175,"K",1,"MDR","DM","hydrophobic","hydrophobic","non-polar","basic","non-polar","pos",11.016,-0.207,-1.311,2.59826,-4.252,-0.95,78,85,-0.521,7,7,0,0,"helix",-2.03333333333333,6.81,7.18700589334483e-05,9.70142977291842,188179.926264637,Inf,0.763784339928386,-16,-36,0,0,-36,0,0,0,0,-2,0,-2,0,0,0,0,0,-5,0,-4,-1,-2,0,2,-2,-0.0524316109422492,-0.338759689922481,0.0946342849234042,-0.724978687127025,-0.24869109947644,0.821052631578947,-0.429159802306425,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.674,-0.411,"7:7","120/150","F:M:I:W:C:L:V",12.1451538387265,0.919026337424235,119.468044436234,0.101660271548255,5.01153666062558e-06,NA,0.986835744238421,0.170978870202674,0.767057556984365,0.124324963210678,Inf,0.382146811758261,"lineage4","dr_mutations_pyrazinamide","LYS",0,"ERR040122","ERR040122","lineage4.8","ug","Uganda","pnca_p.met175lys","A","H","MET","MA175","pnca_complex.pdb"
|
|
"M175K","L4","PZA","M","M175",175,"K",NA,"Pre-MDR","DM","hydrophobic","hydrophobic","non-polar","basic","non-polar","pos",11.016,-0.207,-1.311,2.59826,-4.252,-0.95,78,85,-0.521,7,7,0,0,"helix",-2.03333333333333,6.81,7.18700589334483e-05,9.70142977291842,188179.926264637,Inf,0.763784339928386,-16,-36,0,0,-36,0,0,0,0,-2,0,-2,0,0,0,0,0,-5,0,-4,-1,-2,0,2,-2,-0.0524316109422492,-0.338759689922481,0.0946342849234042,-0.724978687127025,-0.24869109947644,0.821052631578947,-0.429159802306425,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.674,-0.411,"7:7","120/150","F:M:I:W:C:L:V",12.1451538387265,0.919026337424235,119.468044436234,0.101660271548255,5.01153666062558e-06,NA,0.986835744238421,0.170978870202674,0.767057556984365,0.124324963210678,Inf,0.382146811758261,"lineage4","dr_mutations_pyrazinamide","LYS",0,"SRR5065492","SRR5065492","lineage4.8","vn","Vietnam","pnca_p.met175lys","A","H","MET","MA175","pnca_complex.pdb"
|
|
"M175R","L4","PZA","M","M175",175,"R",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",11.016,-0.698,-1.175,2.37207,-3.407,-0.8,74,85,-0.521,7,7,0,0,"helix",-2.03333333333333,6.81,7.18700589334483e-05,9.70142977291842,188179.92626466,Inf,0.763784339928386,-36,-40,0,-2,-38,0,0,0,0,-2,0,-2,0,0,0,0,0,-9,0,-4,-5,-4,0,-6,0,-0.176798378926039,-0.303617571059431,0.0863959527677212,-0.580903665814152,-0.209424083769634,0.778947368421053,-0.429159802306425,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.674,-0.411,"7:7","120/150","F:M:I:W:C:L:V",12.1451538387266,0.919026337424239,119.46804443624,0.10166027154825,5.01153666061918e-06,NA,0.986835744238421,0.170978870202674,0.767057556984365,0.124324963210678,Inf,0.382146811758261,"lineage4","dr_mutations_pyrazinamide","ARG",0,"SAMN02628523","SRR1172252_SRR1180184_SRR1183085_SRR1172151","lineage4.8","ir","Iran","pnca_p.met175arg","A","H","MET","MA175","pnca_complex.pdb"
|
|
"M175R","L2","PZA","M","M175",175,"R",1,"XDR","DM","hydrophobic","hydrophilic","non-polar","basic","non-polar","pos",11.016,-0.698,-1.175,2.37207,-3.407,-0.8,74,85,-0.521,7,7,0,0,"helix",-2.03333333333333,6.81,7.18700589334483e-05,9.70142977291842,188179.92626466,Inf,0.763784339928386,-36,-40,0,-2,-38,0,0,0,0,-2,0,-2,0,0,0,0,0,-9,0,-4,-5,-4,0,-6,0,-0.176798378926039,-0.303617571059431,0.0863959527677212,-0.580903665814152,-0.209424083769634,0.778947368421053,-0.429159802306425,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.674,-0.411,"7:7","120/150","F:M:I:W:C:L:V",12.1451538387266,0.919026337424239,119.46804443624,0.10166027154825,5.01153666061918e-06,NA,0.986835744238421,0.170978870202674,0.767057556984365,0.124324963210678,Inf,0.382146811758261,"lineage2","dr_mutations_pyrazinamide","ARG",0,"SAMN10961305","SRR8651558","lineage2.2.2","cn","China:Wenzhou","pnca_p.met175arg","A","H","MET","MA175","pnca_complex.pdb"
|
|
"M175T","L1","PZA","M","M175",175,"T",NA,"Pre-MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",11.016,0.116,-2.131,2.83612,-3.057,-1.73,72,85,-0.521,7,7,0,0,"helix",-2.03333333333333,6.81,0.0002156101768003,29.1287878787879,511969.848428383,Inf,9.2872640727157,24,0,0,0,0,0,0,0,0,-2,0,-2,0,0,0,0,0,-4,0,-4,0,10,0,10,8,0.0520179372197309,-0.550645994832041,0.103297663881584,-0.521227621483376,-0.452879581151832,0.757894736842105,-0.429159802306425,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.674,-0.411,"7:7","120/150","F:M:I:W:C:L:V",13.1460210124993,0.907969111549572,113.719344731884,0.115600569485285,0.183926936278602,NA,1.4643224129316,0.0049931328456149,2.3016268790981,2.00455510251839,Inf,0.0023075254069185,"lineage1","dr_mutations_pyrazinamide","THR",0,"ERR1213948","ERR1213948","lineage1.2.2","bd","Bangladesh","pnca_p.met175thr","A","H","MET","MA175","pnca_complex.pdb"
|
|
"M175T","L4","PZA","M","M175",175,"T",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",11.016,0.116,-2.131,2.83612,-3.057,-1.73,72,85,-0.521,7,7,0,0,"helix",-2.03333333333333,6.81,0.0002156101768003,29.1287878787879,511969.848428383,Inf,9.2872640727157,24,0,0,0,0,0,0,0,0,-2,0,-2,0,0,0,0,0,-4,0,-4,0,10,0,10,8,0.0520179372197309,-0.550645994832041,0.103297663881584,-0.521227621483376,-0.452879581151832,0.757894736842105,-0.429159802306425,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.674,-0.411,"7:7","120/150","F:M:I:W:C:L:V",13.1460210124993,0.907969111549572,113.719344731884,0.115600569485285,0.183926936278602,NA,1.4643224129316,0.0049931328456149,2.3016268790981,2.00455510251839,Inf,0.0023075254069185,"lineage4","dr_mutations_pyrazinamide","THR",0,"SAMN02584584","SRR1168995_SRR1166305","lineage4.3.3","md","Moldova","pnca_p.met175thr","A","H","MET","MA175","pnca_complex.pdb"
|
|
"M175T","L2","PZA","M","M175",175,"T",1,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",11.016,0.116,-2.131,2.83612,-3.057,-1.73,72,85,-0.521,7,7,0,0,"helix",-2.03333333333333,6.81,0.0002156101768003,29.1287878787879,511969.848428383,Inf,9.2872640727157,24,0,0,0,0,0,0,0,0,-2,0,-2,0,0,0,0,0,-4,0,-4,0,10,0,10,8,0.0520179372197309,-0.550645994832041,0.103297663881584,-0.521227621483376,-0.452879581151832,0.757894736842105,-0.429159802306425,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.674,-0.411,"7:7","120/150","F:M:I:W:C:L:V",13.1460210124993,0.907969111549572,113.719344731884,0.115600569485285,0.183926936278602,NA,1.4643224129316,0.0049931328456149,2.3016268790981,2.00455510251839,Inf,0.0023075254069185,"lineage2","dr_mutations_pyrazinamide","THR",0,"SAMN10961356","SRR8651597","lineage2.2.1","cn","China:Wenzhou","pnca_p.met175thr","A","H","MET","MA175","pnca_complex.pdb"
|
|
"M175T","L4","PZA","M","M175",175,"T",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",11.016,0.116,-2.131,2.83612,-3.057,-1.73,72,85,-0.521,7,7,0,0,"helix",-2.03333333333333,6.81,0.0002156101768003,29.1287878787879,511969.848428383,Inf,9.2872640727157,24,0,0,0,0,0,0,0,0,-2,0,-2,0,0,0,0,0,-4,0,-4,0,10,0,10,8,0.0520179372197309,-0.550645994832041,0.103297663881584,-0.521227621483376,-0.452879581151832,0.757894736842105,-0.429159802306425,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.674,-0.411,"7:7","120/150","F:M:I:W:C:L:V",13.1460210124993,0.907969111549572,113.719344731884,0.115600569485285,0.183926936278602,NA,1.4643224129316,0.0049931328456149,2.3016268790981,2.00455510251839,Inf,0.0023075254069185,"lineage4","dr_mutations_pyrazinamide","THR",0,"ERR3335757","ERR3335757","lineage4.5","pk","Pakistan","pnca_p.met175thr","A","H","MET","MA175","pnca_complex.pdb"
|
|
"M175T","L4","PZA","M","M175",175,"T",NA,"Pre-MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",11.016,0.116,-2.131,2.83612,-3.057,-1.73,72,85,-0.521,7,7,0,0,"helix",-2.03333333333333,6.81,0.0002156101768003,29.1287878787879,511969.848428383,Inf,9.2872640727157,24,0,0,0,0,0,0,0,0,-2,0,-2,0,0,0,0,0,-4,0,-4,0,10,0,10,8,0.0520179372197309,-0.550645994832041,0.103297663881584,-0.521227621483376,-0.452879581151832,0.757894736842105,-0.429159802306425,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.674,-0.411,"7:7","120/150","F:M:I:W:C:L:V",13.1460210124993,0.907969111549572,113.719344731884,0.115600569485285,0.183926936278602,NA,1.4643224129316,0.0049931328456149,2.3016268790981,2.00455510251839,Inf,0.0023075254069185,"lineage4","dr_mutations_pyrazinamide","THR",0,"ERR1193894","ERR1193894","lineage4.3.4.2.1","sz","Swaziland","pnca_p.met175thr","A","H","MET","MA175","pnca_complex.pdb"
|
|
"M175T","L2","PZA","M","M175",175,"T",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",11.016,0.116,-2.131,2.83612,-3.057,-1.73,72,85,-0.521,7,7,0,0,"helix",-2.03333333333333,6.81,0.0002156101768003,29.1287878787879,511969.848428383,Inf,9.2872640727157,24,0,0,0,0,0,0,0,0,-2,0,-2,0,0,0,0,0,-4,0,-4,0,10,0,10,8,0.0520179372197309,-0.550645994832041,0.103297663881584,-0.521227621483376,-0.452879581151832,0.757894736842105,-0.429159802306425,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.674,-0.411,"7:7","120/150","F:M:I:W:C:L:V",13.1460210124993,0.907969111549572,113.719344731884,0.115600569485285,0.183926936278602,NA,1.4643224129316,0.0049931328456149,2.3016268790981,2.00455510251839,Inf,0.0023075254069185,"lineage2","dr_mutations_pyrazinamide","THR",0,"SAMN02403489","SRR1173382_SRR1165271_SRR1173168_SRR1167177","lineage2.2.2","za","South Africa","pnca_p.met175thr","A","H","MET","MA175","pnca_complex.pdb"
|
|
"M175T","L2","PZA","M","M175",175,"T",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",11.016,0.116,-2.131,2.83612,-3.057,-1.73,72,85,-0.521,7,7,0,0,"helix",-2.03333333333333,6.81,0.0002156101768003,29.1287878787879,511969.848428383,Inf,9.2872640727157,24,0,0,0,0,0,0,0,0,-2,0,-2,0,0,0,0,0,-4,0,-4,0,10,0,10,8,0.0520179372197309,-0.550645994832041,0.103297663881584,-0.521227621483376,-0.452879581151832,0.757894736842105,-0.429159802306425,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.674,-0.411,"7:7","120/150","F:M:I:W:C:L:V",13.1460210124993,0.907969111549572,113.719344731884,0.115600569485285,0.183926936278602,NA,1.4643224129316,0.0049931328456149,2.3016268790981,2.00455510251839,Inf,0.0023075254069185,"lineage2","dr_mutations_pyrazinamide","THR",0,"ERR3276277","ERR3276277","lineage2.2.1","nl","Netherlands","pnca_p.met175thr","A","H","MET","MA175","pnca_complex.pdb"
|
|
"M175T","L2","PZA","M","M175",175,"T",NA,"Pre-MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",11.016,0.116,-2.131,2.83612,-3.057,-1.73,72,85,-0.521,7,7,0,0,"helix",-2.03333333333333,6.81,0.0002156101768003,29.1287878787879,511969.848428383,Inf,9.2872640727157,24,0,0,0,0,0,0,0,0,-2,0,-2,0,0,0,0,0,-4,0,-4,0,10,0,10,8,0.0520179372197309,-0.550645994832041,0.103297663881584,-0.521227621483376,-0.452879581151832,0.757894736842105,-0.429159802306425,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.674,-0.411,"7:7","120/150","F:M:I:W:C:L:V",13.1460210124993,0.907969111549572,113.719344731884,0.115600569485285,0.183926936278602,NA,1.4643224129316,0.0049931328456149,2.3016268790981,2.00455510251839,Inf,0.0023075254069185,"lineage2","dr_mutations_pyrazinamide","THR",0,"SRS797257","SRR1723783","lineage2.2.1","cn","China:Guangdong","pnca_p.met175thr","A","H","MET","MA175","pnca_complex.pdb"
|
|
"M175T","L2","PZA","M","M175",175,"T",1,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",11.016,0.116,-2.131,2.83612,-3.057,-1.73,72,85,-0.521,7,7,0,0,"helix",-2.03333333333333,6.81,0.0002156101768003,29.1287878787879,511969.848428383,Inf,9.2872640727157,24,0,0,0,0,0,0,0,0,-2,0,-2,0,0,0,0,0,-4,0,-4,0,10,0,10,8,0.0520179372197309,-0.550645994832041,0.103297663881584,-0.521227621483376,-0.452879581151832,0.757894736842105,-0.429159802306425,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.674,-0.411,"7:7","120/150","F:M:I:W:C:L:V",13.1460210124993,0.907969111549572,113.719344731884,0.115600569485285,0.183926936278602,NA,1.4643224129316,0.0049931328456149,2.3016268790981,2.00455510251839,Inf,0.0023075254069185,"lineage2","dr_mutations_pyrazinamide","THR",0,"MDR_19261","SRR6824406","lineage2.2.1","cn","China: Luoding City, Yunfu City, Guangdong Province","pnca_p.met175thr","A","H","MET","MA175","pnca_complex.pdb"
|
|
"M175T","L4","PZA","M","M175",175,"T",1,"Pre-MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",11.016,0.116,-2.131,2.83612,-3.057,-1.73,72,85,-0.521,7,7,0,0,"helix",-2.03333333333333,6.81,0.0002156101768003,29.1287878787879,511969.848428383,Inf,9.2872640727157,24,0,0,0,0,0,0,0,0,-2,0,-2,0,0,0,0,0,-4,0,-4,0,10,0,10,8,0.0520179372197309,-0.550645994832041,0.103297663881584,-0.521227621483376,-0.452879581151832,0.757894736842105,-0.429159802306425,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.674,-0.411,"7:7","120/150","F:M:I:W:C:L:V",13.1460210124993,0.907969111549572,113.719344731884,0.115600569485285,0.183926936278602,NA,1.4643224129316,0.0049931328456149,2.3016268790981,2.00455510251839,Inf,0.0023075254069185,"lineage4","dr_mutations_pyrazinamide","THR",0,"ERR552352","ERR552352","lineage4.3.4.2.1","sz","Swaziland","pnca_p.met175thr","A","H","MET","MA175","pnca_complex.pdb"
|
|
"M175T","L4","PZA","M","M175",175,"T",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",11.016,0.116,-2.131,2.83612,-3.057,-1.73,72,85,-0.521,7,7,0,0,"helix",-2.03333333333333,6.81,0.0002156101768003,29.1287878787879,511969.848428383,Inf,9.2872640727157,24,0,0,0,0,0,0,0,0,-2,0,-2,0,0,0,0,0,-4,0,-4,0,10,0,10,8,0.0520179372197309,-0.550645994832041,0.103297663881584,-0.521227621483376,-0.452879581151832,0.757894736842105,-0.429159802306425,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.674,-0.411,"7:7","120/150","F:M:I:W:C:L:V",13.1460210124993,0.907969111549572,113.719344731884,0.115600569485285,0.183926936278602,NA,1.4643224129316,0.0049931328456149,2.3016268790981,2.00455510251839,Inf,0.0023075254069185,"lineage4","dr_mutations_pyrazinamide","THR",0,"SRR671831,BGI_ShX321","SRR671831","lineage4.4.2","cn","China","pnca_p.met175thr","A","H","MET","MA175","pnca_complex.pdb"
|
|
"M175T","L2","PZA","M","M175",175,"T",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",11.016,0.116,-2.131,2.83612,-3.057,-1.73,72,85,-0.521,7,7,0,0,"helix",-2.03333333333333,6.81,0.0002156101768003,29.1287878787879,511969.848428383,Inf,9.2872640727157,24,0,0,0,0,0,0,0,0,-2,0,-2,0,0,0,0,0,-4,0,-4,0,10,0,10,8,0.0520179372197309,-0.550645994832041,0.103297663881584,-0.521227621483376,-0.452879581151832,0.757894736842105,-0.429159802306425,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.674,-0.411,"7:7","120/150","F:M:I:W:C:L:V",13.1460210124993,0.907969111549572,113.719344731884,0.115600569485285,0.183926936278602,NA,1.4643224129316,0.0049931328456149,2.3016268790981,2.00455510251839,Inf,0.0023075254069185,"lineage2","dr_mutations_pyrazinamide","THR",0,"ERR502941","ERR502941","lineage2.2.1","","","pnca_p.met175thr","A","H","MET","MA175","pnca_complex.pdb"
|
|
"M175T","L4","PZA","M","M175",175,"T",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","polar",11.016,0.116,-2.131,2.83612,-3.057,-1.73,72,85,-0.521,7,7,0,0,"helix",-2.03333333333333,6.81,0.0002156101768003,29.1287878787879,511969.848428383,Inf,9.2872640727157,24,0,0,0,0,0,0,0,0,-2,0,-2,0,0,0,0,0,-4,0,-4,0,10,0,10,8,0.0520179372197309,-0.550645994832041,0.103297663881584,-0.521227621483376,-0.452879581151832,0.757894736842105,-0.429159802306425,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.674,-0.411,"7:7","120/150","F:M:I:W:C:L:V",13.1460210124993,0.907969111549572,113.719344731884,0.115600569485285,0.183926936278602,NA,1.4643224129316,0.0049931328456149,2.3016268790981,2.00455510251839,Inf,0.0023075254069185,"lineage4","dr_mutations_pyrazinamide","THR",0,"SAMN02584648","SRR1166116_SRR1169082","lineage4.3.3","md","Moldova","pnca_p.met175thr","A","H","MET","MA175","pnca_complex.pdb"
|
|
"M175V","L4","PZA","M","M175",175,"V",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",11.016,-1.081,-1.251,2.746,-2.087,-1.13,52,75,-0.521,7,7,0,0,"helix",-2.03333333333333,6.81,0.0007187005893344,11.3440134907251,11.3439859738742,11.3408060961982,16.1999449415698,24,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-2,0,-4,0,8,0,8,8,-0.273809523809524,-0.323255813953488,0.100015297314229,-0.355839727195226,-0.295811518324607,0.547368421052632,-0.429159802306425,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.674,-0.411,"7:7","120/150","F:M:I:W:C:L:V",2.42868773335338,0.0004314327258942,0.689954362035746,3.52007011911253,3.15129211999938,52.6672541515188,1.05476673431854,0.000313793551117,3.50335598599778,2.58674701617199,67.9086927550226,5.69957727561539e-05,"lineage4","dr_mutations_pyrazinamide","VAL",0,"ERR2707135","ERR2707135","lineage4.3.3","cd","Democratic Republic of Congo","pnca_p.met175val","A","H","MET","MA175","pnca_complex.pdb"
|
|
"M175V","L4","PZA","M","M175",175,"V",1,"Pre-MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",11.016,-1.081,-1.251,2.746,-2.087,-1.13,52,75,-0.521,7,7,0,0,"helix",-2.03333333333333,6.81,0.0007187005893344,11.3440134907251,11.3439859738742,11.3408060961982,16.1999449415698,24,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-2,0,-4,0,8,0,8,8,-0.273809523809524,-0.323255813953488,0.100015297314229,-0.355839727195226,-0.295811518324607,0.547368421052632,-0.429159802306425,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.674,-0.411,"7:7","120/150","F:M:I:W:C:L:V",2.42868773335338,0.0004314327258942,0.689954362035746,3.52007011911253,3.15129211999938,52.6672541515188,1.05476673431854,0.000313793551117,3.50335598599778,2.58674701617199,67.9086927550226,5.69957727561539e-05,"lineage4","dr_mutations_pyrazinamide","VAL",0,"SRR6339666","SRR6339666","lineage4.8","au","Australia","pnca_p.met175val","A","H","MET","MA175","pnca_complex.pdb"
|
|
"M175V","L4","PZA","M","M175",175,"V",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",11.016,-1.081,-1.251,2.746,-2.087,-1.13,52,75,-0.521,7,7,0,0,"helix",-2.03333333333333,6.81,0.0007187005893344,11.3440134907251,11.3439859738742,11.3408060961982,16.1999449415698,24,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-2,0,-4,0,8,0,8,8,-0.273809523809524,-0.323255813953488,0.100015297314229,-0.355839727195226,-0.295811518324607,0.547368421052632,-0.429159802306425,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.674,-0.411,"7:7","120/150","F:M:I:W:C:L:V",2.42868773335338,0.0004314327258942,0.689954362035746,3.52007011911253,3.15129211999938,52.6672541515188,1.05476673431854,0.000313793551117,3.50335598599778,2.58674701617199,67.9086927550226,5.69957727561539e-05,"lineage4","dr_mutations_pyrazinamide","VAL",0,"ERR775385","ERR775385","lineage4.1.1.3","pe","","pnca_p.met175val","A","H","MET","MA175","pnca_complex.pdb"
|
|
"M175V","L2","PZA","M","M175",175,"V",1,"XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",11.016,-1.081,-1.251,2.746,-2.087,-1.13,52,75,-0.521,7,7,0,0,"helix",-2.03333333333333,6.81,0.0007187005893344,11.3440134907251,11.3439859738742,11.3408060961982,16.1999449415698,24,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-2,0,-4,0,8,0,8,8,-0.273809523809524,-0.323255813953488,0.100015297314229,-0.355839727195226,-0.295811518324607,0.547368421052632,-0.429159802306425,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.674,-0.411,"7:7","120/150","F:M:I:W:C:L:V",2.42868773335338,0.0004314327258942,0.689954362035746,3.52007011911253,3.15129211999938,52.6672541515188,1.05476673431854,0.000313793551117,3.50335598599778,2.58674701617199,67.9086927550226,5.69957727561539e-05,"lineage2","dr_mutations_pyrazinamide","VAL",0,"ERR2516291","ERR2516291","lineage2.2.1","be","Belgium","pnca_p.met175val","A","H","MET","MA175","pnca_complex.pdb"
|
|
"M175V","L2","PZA","M","M175",175,"V",1,"XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",11.016,-1.081,-1.251,2.746,-2.087,-1.13,52,75,-0.521,7,7,0,0,"helix",-2.03333333333333,6.81,0.0007187005893344,11.3440134907251,11.3439859738742,11.3408060961982,16.1999449415698,24,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-2,0,-4,0,8,0,8,8,-0.273809523809524,-0.323255813953488,0.100015297314229,-0.355839727195226,-0.295811518324607,0.547368421052632,-0.429159802306425,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.674,-0.411,"7:7","120/150","F:M:I:W:C:L:V",2.42868773335338,0.0004314327258942,0.689954362035746,3.52007011911253,3.15129211999938,52.6672541515188,1.05476673431854,0.000313793551117,3.50335598599778,2.58674701617199,67.9086927550226,5.69957727561539e-05,"lineage2","dr_mutations_pyrazinamide","VAL",0,"ERR2516256","ERR2516256","lineage2.2.1","be","Belgium","pnca_p.met175val","A","H","MET","MA175","pnca_complex.pdb"
|
|
"M175V","L2","PZA","M","M175",175,"V",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",11.016,-1.081,-1.251,2.746,-2.087,-1.13,52,75,-0.521,7,7,0,0,"helix",-2.03333333333333,6.81,0.0007187005893344,11.3440134907251,11.3439859738742,11.3408060961982,16.1999449415698,24,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-2,0,-4,0,8,0,8,8,-0.273809523809524,-0.323255813953488,0.100015297314229,-0.355839727195226,-0.295811518324607,0.547368421052632,-0.429159802306425,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.674,-0.411,"7:7","120/150","F:M:I:W:C:L:V",2.42868773335338,0.0004314327258942,0.689954362035746,3.52007011911253,3.15129211999938,52.6672541515188,1.05476673431854,0.000313793551117,3.50335598599778,2.58674701617199,67.9086927550226,5.69957727561539e-05,"lineage2","dr_mutations_pyrazinamide","VAL",0,"SRS935971,SAMN03653236","SRR2024931","lineage2.2.1","cn","China","pnca_p.met175val","A","H","MET","MA175","pnca_complex.pdb"
|
|
"M175V","L2","PZA","M","M175",175,"V",NA,"XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",11.016,-1.081,-1.251,2.746,-2.087,-1.13,52,75,-0.521,7,7,0,0,"helix",-2.03333333333333,6.81,0.0007187005893344,11.3440134907251,11.3439859738742,11.3408060961982,16.1999449415698,24,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-2,0,-4,0,8,0,8,8,-0.273809523809524,-0.323255813953488,0.100015297314229,-0.355839727195226,-0.295811518324607,0.547368421052632,-0.429159802306425,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.674,-0.411,"7:7","120/150","F:M:I:W:C:L:V",2.42868773335338,0.0004314327258942,0.689954362035746,3.52007011911253,3.15129211999938,52.6672541515188,1.05476673431854,0.000313793551117,3.50335598599778,2.58674701617199,67.9086927550226,5.69957727561539e-05,"lineage2","dr_mutations_pyrazinamide","VAL",0,"ERR2516359","ERR2516359","lineage2.2.1","be","Belgium","pnca_p.met175val","A","H","MET","MA175","pnca_complex.pdb"
|
|
"M175V","L2","PZA","M","M175",175,"V",1,"XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",11.016,-1.081,-1.251,2.746,-2.087,-1.13,52,75,-0.521,7,7,0,0,"helix",-2.03333333333333,6.81,0.0007187005893344,11.3440134907251,11.3439859738742,11.3408060961982,16.1999449415698,24,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-2,0,-4,0,8,0,8,8,-0.273809523809524,-0.323255813953488,0.100015297314229,-0.355839727195226,-0.295811518324607,0.547368421052632,-0.429159802306425,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.674,-0.411,"7:7","120/150","F:M:I:W:C:L:V",2.42868773335338,0.0004314327258942,0.689954362035746,3.52007011911253,3.15129211999938,52.6672541515188,1.05476673431854,0.000313793551117,3.50335598599778,2.58674701617199,67.9086927550226,5.69957727561539e-05,"lineage2","dr_mutations_pyrazinamide","VAL",0,"MDR_12257","SRR6824505","lineage2.2.1","cn","China: Ma'anshan City, Anhui Province","pnca_p.met175val","A","H","MET","MA175","pnca_complex.pdb"
|
|
"M175V","L3","PZA","M","M175",175,"V",0,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",11.016,-1.081,-1.251,2.746,-2.087,-1.13,52,75,-0.521,7,7,0,0,"helix",-2.03333333333333,6.81,0.0007187005893344,11.3440134907251,11.3439859738742,11.3408060961982,16.1999449415698,24,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-2,0,-4,0,8,0,8,8,-0.273809523809524,-0.323255813953488,0.100015297314229,-0.355839727195226,-0.295811518324607,0.547368421052632,-0.429159802306425,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.674,-0.411,"7:7","120/150","F:M:I:W:C:L:V",2.42868773335338,0.0004314327258942,0.689954362035746,3.52007011911253,3.15129211999938,52.6672541515188,1.05476673431854,0.000313793551117,3.50335598599778,2.58674701617199,67.9086927550226,5.69957727561539e-05,"lineage3","dr_mutations_pyrazinamide","VAL",0,"ERR2517020","ERR2517020","lineage3","gb","UK","pnca_p.met175val","A","H","MET","MA175","pnca_complex.pdb"
|
|
"M175V","L2","PZA","M","M175",175,"V",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",11.016,-1.081,-1.251,2.746,-2.087,-1.13,52,75,-0.521,7,7,0,0,"helix",-2.03333333333333,6.81,0.0007187005893344,11.3440134907251,11.3439859738742,11.3408060961982,16.1999449415698,24,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-2,0,-4,0,8,0,8,8,-0.273809523809524,-0.323255813953488,0.100015297314229,-0.355839727195226,-0.295811518324607,0.547368421052632,-0.429159802306425,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.674,-0.411,"7:7","120/150","F:M:I:W:C:L:V",2.42868773335338,0.0004314327258942,0.689954362035746,3.52007011911253,3.15129211999938,52.6672541515188,1.05476673431854,0.000313793551117,3.50335598599778,2.58674701617199,67.9086927550226,5.69957727561539e-05,"lineage2","dr_mutations_pyrazinamide","VAL",0,"SAMN03653319,SRS935942","SRR2024902","lineage2.2.1","cn","China","pnca_p.met175val","A","H","MET","MA175","pnca_complex.pdb"
|
|
"M175V","L2","PZA","M","M175",175,"V",NA,"XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",11.016,-1.081,-1.251,2.746,-2.087,-1.13,52,75,-0.521,7,7,0,0,"helix",-2.03333333333333,6.81,0.0007187005893344,11.3440134907251,11.3439859738742,11.3408060961982,16.1999449415698,24,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-2,0,-4,0,8,0,8,8,-0.273809523809524,-0.323255813953488,0.100015297314229,-0.355839727195226,-0.295811518324607,0.547368421052632,-0.429159802306425,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.674,-0.411,"7:7","120/150","F:M:I:W:C:L:V",2.42868773335338,0.0004314327258942,0.689954362035746,3.52007011911253,3.15129211999938,52.6672541515188,1.05476673431854,0.000313793551117,3.50335598599778,2.58674701617199,67.9086927550226,5.69957727561539e-05,"lineage2","dr_mutations_pyrazinamide","VAL",0,"ERR502929","ERR502929","lineage2.2.1","","","pnca_p.met175val","A","H","MET","MA175","pnca_complex.pdb"
|
|
"M175V","L2","PZA","M","M175",175,"V",1,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",11.016,-1.081,-1.251,2.746,-2.087,-1.13,52,75,-0.521,7,7,0,0,"helix",-2.03333333333333,6.81,0.0007187005893344,11.3440134907251,11.3439859738742,11.3408060961982,16.1999449415698,24,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-2,0,-4,0,8,0,8,8,-0.273809523809524,-0.323255813953488,0.100015297314229,-0.355839727195226,-0.295811518324607,0.547368421052632,-0.429159802306425,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.674,-0.411,"7:7","120/150","F:M:I:W:C:L:V",2.42868773335338,0.0004314327258942,0.689954362035746,3.52007011911253,3.15129211999938,52.6672541515188,1.05476673431854,0.000313793551117,3.50335598599778,2.58674701617199,67.9086927550226,5.69957727561539e-05,"lineage2","dr_mutations_pyrazinamide","VAL",0,"ERR2516910","ERR2516910","lineage2.2.1","gb","UK","pnca_p.met175val","A","H","MET","MA175","pnca_complex.pdb"
|
|
"M175V","L2","PZA","M","M175",175,"V",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",11.016,-1.081,-1.251,2.746,-2.087,-1.13,52,75,-0.521,7,7,0,0,"helix",-2.03333333333333,6.81,0.0007187005893344,11.3440134907251,11.3439859738742,11.3408060961982,16.1999449415698,24,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-2,0,-4,0,8,0,8,8,-0.273809523809524,-0.323255813953488,0.100015297314229,-0.355839727195226,-0.295811518324607,0.547368421052632,-0.429159802306425,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.674,-0.411,"7:7","120/150","F:M:I:W:C:L:V",2.42868773335338,0.0004314327258942,0.689954362035746,3.52007011911253,3.15129211999938,52.6672541515188,1.05476673431854,0.000313793551117,3.50335598599778,2.58674701617199,67.9086927550226,5.69957727561539e-05,"lineage2","dr_mutations_pyrazinamide","VAL",0,"SAMN02628526","SRR1180141_SRR1172288_SRR1183064_SRR1172183","lineage2.2.1","ir","Iran","pnca_p.met175val","A","H","MET","MA175","pnca_complex.pdb"
|
|
"M175V","L4","PZA","M","M175",175,"V",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",11.016,-1.081,-1.251,2.746,-2.087,-1.13,52,75,-0.521,7,7,0,0,"helix",-2.03333333333333,6.81,0.0007187005893344,11.3440134907251,11.3439859738742,11.3408060961982,16.1999449415698,24,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-2,0,-4,0,8,0,8,8,-0.273809523809524,-0.323255813953488,0.100015297314229,-0.355839727195226,-0.295811518324607,0.547368421052632,-0.429159802306425,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.674,-0.411,"7:7","120/150","F:M:I:W:C:L:V",2.42868773335338,0.0004314327258942,0.689954362035746,3.52007011911253,3.15129211999938,52.6672541515188,1.05476673431854,0.000313793551117,3.50335598599778,2.58674701617199,67.9086927550226,5.69957727561539e-05,"lineage4","dr_mutations_pyrazinamide","VAL",0,"ERR751576","ERR751576","lineage4.1.2.1","pe","","pnca_p.met175val","A","H","MET","MA175","pnca_complex.pdb"
|
|
"M175V","L2","PZA","M","M175",175,"V",1,"MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",11.016,-1.081,-1.251,2.746,-2.087,-1.13,52,75,-0.521,7,7,0,0,"helix",-2.03333333333333,6.81,0.0007187005893344,11.3440134907251,11.3439859738742,11.3408060961982,16.1999449415698,24,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-2,0,-4,0,8,0,8,8,-0.273809523809524,-0.323255813953488,0.100015297314229,-0.355839727195226,-0.295811518324607,0.547368421052632,-0.429159802306425,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.674,-0.411,"7:7","120/150","F:M:I:W:C:L:V",2.42868773335338,0.0004314327258942,0.689954362035746,3.52007011911253,3.15129211999938,52.6672541515188,1.05476673431854,0.000313793551117,3.50335598599778,2.58674701617199,67.9086927550226,5.69957727561539e-05,"lineage2","dr_mutations_pyrazinamide","VAL",0,"ERS2592796","ERR2677451","lineage2.2.1","de","Germany","pnca_p.met175val","A","H","MET","MA175","pnca_complex.pdb"
|
|
"M175V","L4","PZA","M","M175",175,"V",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",11.016,-1.081,-1.251,2.746,-2.087,-1.13,52,75,-0.521,7,7,0,0,"helix",-2.03333333333333,6.81,0.0007187005893344,11.3440134907251,11.3439859738742,11.3408060961982,16.1999449415698,24,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-2,0,-4,0,8,0,8,8,-0.273809523809524,-0.323255813953488,0.100015297314229,-0.355839727195226,-0.295811518324607,0.547368421052632,-0.429159802306425,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.674,-0.411,"7:7","120/150","F:M:I:W:C:L:V",2.42868773335338,0.0004314327258942,0.689954362035746,3.52007011911253,3.15129211999938,52.6672541515188,1.05476673431854,0.000313793551117,3.50335598599778,2.58674701617199,67.9086927550226,5.69957727561539e-05,"lineage4","dr_mutations_pyrazinamide","VAL",0,"ERR775386","ERR775386","lineage4.1.2.1","pe","","pnca_p.met175val","A","H","MET","MA175","pnca_complex.pdb"
|
|
"M175V","L2","PZA","M","M175",175,"V",0,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",11.016,-1.081,-1.251,2.746,-2.087,-1.13,52,75,-0.521,7,7,0,0,"helix",-2.03333333333333,6.81,0.0007187005893344,11.3440134907251,11.3439859738742,11.3408060961982,16.1999449415698,24,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-2,0,-4,0,8,0,8,8,-0.273809523809524,-0.323255813953488,0.100015297314229,-0.355839727195226,-0.295811518324607,0.547368421052632,-0.429159802306425,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.674,-0.411,"7:7","120/150","F:M:I:W:C:L:V",2.42868773335338,0.0004314327258942,0.689954362035746,3.52007011911253,3.15129211999938,52.6672541515188,1.05476673431854,0.000313793551117,3.50335598599778,2.58674701617199,67.9086927550226,5.69957727561539e-05,"lineage2","dr_mutations_pyrazinamide","VAL",0,"ERS458602","ERR553192_ERR553191","lineage2.2.1","uz","Nukus","pnca_p.met175val","A","H","MET","MA175","pnca_complex.pdb"
|
|
"M175V","L2","PZA","M","M175",175,"V",1,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",11.016,-1.081,-1.251,2.746,-2.087,-1.13,52,75,-0.521,7,7,0,0,"helix",-2.03333333333333,6.81,0.0007187005893344,11.3440134907251,11.3439859738742,11.3408060961982,16.1999449415698,24,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-2,0,-4,0,8,0,8,8,-0.273809523809524,-0.323255813953488,0.100015297314229,-0.355839727195226,-0.295811518324607,0.547368421052632,-0.429159802306425,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.674,-0.411,"7:7","120/150","F:M:I:W:C:L:V",2.42868773335338,0.0004314327258942,0.689954362035746,3.52007011911253,3.15129211999938,52.6672541515188,1.05476673431854,0.000313793551117,3.50335598599778,2.58674701617199,67.9086927550226,5.69957727561539e-05,"lineage2","dr_mutations_pyrazinamide","VAL",0,"ERS458134","ERR552560_ERR552561_ERR552559","lineage2.2.1","uz","Nukus","pnca_p.met175val","A","H","MET","MA175","pnca_complex.pdb"
|
|
"M175V","L3","PZA","M","M175",175,"V",0,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",11.016,-1.081,-1.251,2.746,-2.087,-1.13,52,75,-0.521,7,7,0,0,"helix",-2.03333333333333,6.81,0.0007187005893344,11.3440134907251,11.3439859738742,11.3408060961982,16.1999449415698,24,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-2,0,-4,0,8,0,8,8,-0.273809523809524,-0.323255813953488,0.100015297314229,-0.355839727195226,-0.295811518324607,0.547368421052632,-0.429159802306425,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.674,-0.411,"7:7","120/150","F:M:I:W:C:L:V",2.42868773335338,0.0004314327258942,0.689954362035746,3.52007011911253,3.15129211999938,52.6672541515188,1.05476673431854,0.000313793551117,3.50335598599778,2.58674701617199,67.9086927550226,5.69957727561539e-05,"lineage3","dr_mutations_pyrazinamide","VAL",0,"140603481,SAMN05276311","SRR3675217","lineage3","gb","UK","pnca_p.met175val","A","H","MET","MA175","pnca_complex.pdb"
|
|
"R176C","L4","PZA","R","R176",176,"C",NA,"Sensitive","OM","hydrophilic","hydrophobic","basic","neutral","pos","non-polar",17.132,-0.881,-0.417,1.53676,-0.701,0.75,55,75,1.185,1,1,188,0.686131386861314,"helix",-1.1,3.67,NA,NA,NA,NA,NA,32,22,0,0,22,0,0,0,0,0,0,2,0,0,0,0,0,0,0,-3,3,2,0,2,4,-0.223150962512665,-0.107751937984496,0.0559721443192331,-0.119522591645354,0.421348314606741,0.578947368421053,0.379807692307692,"Destabilising","Destabilising","Destabilising","Destabilising","Stabilising","effect",0.59,1.183,"3:1","116/150","S:M:A:G:T:D:E:Q:N:L:V:K:I:R",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage4","other_mutations_pyrazinamide","CYS",0,"ERR1193718","ERR1193718","lineage4.3","id","Indonesia","pnca_p.arg176cys","A","H","ARG","RA176","pnca_complex.pdb"
|
|
"T177P","L3","PZA","T","T177",177,"P",0,"MDR","OM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",19.207,-0.36,-0.045,0.790967,-0.444,-0.19,21,63,1.87,1,1,126,0.732558139534884,"helix",-1.13333333333333,3.45,0.0002874802357337,4.85191417753471,4.85191414039982,4.85118443551178,1.17497090855698,0,13,0,-2,15,0,0,0,0,2,2,2,0,0,0,0,0,4,4,-1,0,-2,0,-4,-2,-0.0911854103343465,-0.0116279069767441,0.0288087398655293,-0.0757033248081841,-0.0497382198952879,0.221052631578947,0.599358974358974,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",1.183,1.712,"1:1","114/150","N:L:R:K:H:E:Q:D:T:S:M:G:A",1.57937329521209,0.114342297004304,1.0002536454007,1.57897279602454,0.581889091312676,40.456291107532,0.685913110299906,0.137954936368295,0.860262754777729,0.351471331417763,67.0421060419706,0.278382201819561,"lineage3","other_mutations_pyrazinamide","PRO",0,"ERR2510450","ERR2510450","lineage3","pk","Pakistan","pnca_p.thr177pro","A","H","THR","TA177","pnca_complex.pdb"
|
|
"T177P","L2","PZA","T","T177",177,"P",NA,"Pre-XDR","OM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",19.207,-0.36,-0.045,0.790967,-0.444,-0.19,21,63,1.87,1,1,126,0.732558139534884,"helix",-1.13333333333333,3.45,0.0002874802357337,4.85191417753471,4.85191414039982,4.85118443551178,1.17497090855698,0,13,0,-2,15,0,0,0,0,2,2,2,0,0,0,0,0,4,4,-1,0,-2,0,-4,-2,-0.0911854103343465,-0.0116279069767441,0.0288087398655293,-0.0757033248081841,-0.0497382198952879,0.221052631578947,0.599358974358974,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",1.183,1.712,"1:1","114/150","N:L:R:K:H:E:Q:D:T:S:M:G:A",1.57937329521209,0.114342297004304,1.0002536454007,1.57897279602454,0.581889091312676,40.456291107532,0.685913110299906,0.137954936368295,0.860262754777729,0.351471331417763,67.0421060419706,0.278382201819561,"lineage2","other_mutations_pyrazinamide","PRO",0,"OU68-FMRHH25","SRR5341210","lineage2.2.1","in","India","pnca_p.thr177pro","A","H","THR","TA177","pnca_complex.pdb"
|
|
"T177P","L2","PZA","T","T177",177,"P",0,"Pre-XDR","OM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",19.207,-0.36,-0.045,0.790967,-0.444,-0.19,21,63,1.87,1,1,126,0.732558139534884,"helix",-1.13333333333333,3.45,0.0002874802357337,4.85191417753471,4.85191414039982,4.85118443551178,1.17497090855698,0,13,0,-2,15,0,0,0,0,2,2,2,0,0,0,0,0,4,4,-1,0,-2,0,-4,-2,-0.0911854103343465,-0.0116279069767441,0.0288087398655293,-0.0757033248081841,-0.0497382198952879,0.221052631578947,0.599358974358974,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",1.183,1.712,"1:1","114/150","N:L:R:K:H:E:Q:D:T:S:M:G:A",1.57937329521209,0.114342297004304,1.0002536454007,1.57897279602454,0.581889091312676,40.456291107532,0.685913110299906,0.137954936368295,0.860262754777729,0.351471331417763,67.0421060419706,0.278382201819561,"lineage2","other_mutations_pyrazinamide","PRO",0,"ERR2516423","ERR2516423","lineage2.2.1","nl","Netherlands","pnca_p.thr177pro","A","H","THR","TA177","pnca_complex.pdb"
|
|
"T177P","L2","PZA","T","T177",177,"P",1,"Pre-XDR","OM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",19.207,-0.36,-0.045,0.790967,-0.444,-0.19,21,63,1.87,1,1,126,0.732558139534884,"helix",-1.13333333333333,3.45,0.0002874802357337,4.85191417753471,4.85191414039982,4.85118443551178,1.17497090855698,0,13,0,-2,15,0,0,0,0,2,2,2,0,0,0,0,0,4,4,-1,0,-2,0,-4,-2,-0.0911854103343465,-0.0116279069767441,0.0288087398655293,-0.0757033248081841,-0.0497382198952879,0.221052631578947,0.599358974358974,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",1.183,1.712,"1:1","114/150","N:L:R:K:H:E:Q:D:T:S:M:G:A",1.57937329521209,0.114342297004304,1.0002536454007,1.57897279602454,0.581889091312676,40.456291107532,0.685913110299906,0.137954936368295,0.860262754777729,0.351471331417763,67.0421060419706,0.278382201819561,"lineage2","other_mutations_pyrazinamide","PRO",0,"SAMN10961320","SRR8651647","lineage2.2.2","cn","China:Wenzhou","pnca_p.thr177pro","A","H","THR","TA177","pnca_complex.pdb"
|
|
"T177P","L2","PZA","T","T177",177,"P",1,"Pre-XDR","OM","hydrophobic","hydrophilic","neutral","non-polar","polar","non-polar",19.207,-0.36,-0.045,0.790967,-0.444,-0.19,21,63,1.87,1,1,126,0.732558139534884,"helix",-1.13333333333333,3.45,0.0002874802357337,4.85191417753471,4.85191414039982,4.85118443551178,1.17497090855698,0,13,0,-2,15,0,0,0,0,2,2,2,0,0,0,0,0,4,4,-1,0,-2,0,-4,-2,-0.0911854103343465,-0.0116279069767441,0.0288087398655293,-0.0757033248081841,-0.0497382198952879,0.221052631578947,0.599358974358974,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",1.183,1.712,"1:1","114/150","N:L:R:K:H:E:Q:D:T:S:M:G:A",1.57937329521209,0.114342297004304,1.0002536454007,1.57897279602454,0.581889091312676,40.456291107532,0.685913110299906,0.137954936368295,0.860262754777729,0.351471331417763,67.0421060419706,0.278382201819561,"lineage2","other_mutations_pyrazinamide","PRO",0,"ERR2510713","ERR2510713","lineage2.2.1","it","Italy","pnca_p.thr177pro","A","H","THR","TA177","pnca_complex.pdb"
|
|
"A178P","L4","PZA","A","A178",178,"P",NA,"MDR","OM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",17.128,-0.05,-0.485,2.01949,-1.803,-0.09,60,80,-0.496,7,7,32,0.248062015503876,"loop",0.1,3.71,NA,NA,NA,NA,NA,0,-2,0,0,-2,0,0,0,0,2,2,2,0,0,0,0,0,-6,2,-8,-2,0,0,-2,-5,-0.0126646403242147,-0.125322997416021,0.0735542216945053,-0.307416879795396,-0.0235602094240837,0.631578947368421,-0.408566721581549,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.674,-0.411,"7:7","110/150","G:M:A:S:C:K:V:Q:H:E",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage4","other_mutations_pyrazinamide","PRO",0,"ERR1213826","ERR1213826","lineage4.3.4.2.1","rw","Rwanda","pnca_p.ala178pro","A","T","ALA","AA178","pnca_complex.pdb"
|
|
"A178P","L4","PZA","A","A178",178,"P",NA,"MDR","OM","hydrophobic","hydrophilic","non-polar","non-polar","non-polar","non-polar",17.128,-0.05,-0.485,2.01949,-1.803,-0.09,60,80,-0.496,7,7,32,0.248062015503876,"loop",0.1,3.71,NA,NA,NA,NA,NA,0,-2,0,0,-2,0,0,0,0,2,2,2,0,0,0,0,0,-6,2,-8,-2,0,0,-2,-5,-0.0126646403242147,-0.125322997416021,0.0735542216945053,-0.307416879795396,-0.0235602094240837,0.631578947368421,-0.408566721581549,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.674,-0.411,"7:7","110/150","G:M:A:S:C:K:V:Q:H:E",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage4","other_mutations_pyrazinamide","PRO",0,"ERR1213850","ERR1213850","lineage4.3.4.2.1","rw","Rwanda","pnca_p.ala178pro","A","T","ALA","AA178","pnca_complex.pdb"
|
|
"S179I","L2","PZA","S","S179",179,"I",0,"Sensitive","OM","hydrophilic","hydrophobic","neutral","non-polar","polar","non-polar",19.449,-0.451,0.381,1.25588,0.395,-0.66,35,66,-0.876,8,8,87,0.561290322580645,"loop",1.73333333333333,3.5,7.18700589334483e-05,2.42412778478352,0.0001249735077034,0,1.03410070803344e-29,-8,0,0,0,0,0,0,0,0,2,0,2,0,0,0,0,0,0,0,0,0,0,0,0,2,-0.114235055724417,0.323979591836735,0.0457418833179146,0.333614864864865,-0.172774869109948,0.368421052631579,-0.72158154859967,"Destabilising","Stabilising","Destabilising","Stabilising","Destabilising","effect",-1.028,-0.779,"9:8","107/150","W:R:D:Q:S:G",-8.98740878149641,0.940032862253634,119.468044435492,-0.0752285585987746,NA,4692673.510814,0.384555509373631,1,0,0,188.544222231268,0.999999999999997,"lineage2","other_mutations_pyrazinamide","ILE",0,"ERR2514301","ERR2514301","lineage2.2.1","gb","UK","pnca_p.ser179ile","A","T","SER","SA179","pnca_complex.pdb"
|
|
"V180A","L2","PZA","V","V180",180,"A",1,"MDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",15.436,-1.661,-2.048,2.8049,-2.408,-1.98,-8,53,-0.509,7,7,6,0.0344827586206896,"loop",-0.0333333333333332,5.26,0.0001437401178668,19.411022297013,511754.463552312,Inf,4.73122070382274,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-2,0,-4,0,2,0,2,5,-0.420719351570415,-0.529198966408269,0.102160563523918,-0.410571184995737,-0.518324607329843,-0.0860215053763441,-0.419275123558484,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","neutral",-0.674,-0.411,"7:7","102/150","I:L:V:S:A:G",13.14560022562,0.92480376844698,139.277183326525,0.094384449136949,0.0001628371344461,NA,1.28804840845689,0.0292235860951597,1.53426649183163,0.91081598550184,Inf,0.0296198560706035,"lineage2","other_mutations_pyrazinamide","ALA",0,"ERR552136","ERR552136","lineage2.2.1","ru","Russia","pnca_p.val180ala","A","-","VAL","VA180","pnca_complex.pdb"
|
|
"V180A","L2","PZA","V","V180",180,"A",NA,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",15.436,-1.661,-2.048,2.8049,-2.408,-1.98,-8,53,-0.509,7,7,6,0.0344827586206896,"loop",-0.0333333333333332,5.26,0.0001437401178668,19.411022297013,511754.463552312,Inf,4.73122070382274,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-2,0,-4,0,2,0,2,5,-0.420719351570415,-0.529198966408269,0.102160563523918,-0.410571184995737,-0.518324607329843,-0.0860215053763441,-0.419275123558484,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","neutral",-0.674,-0.411,"7:7","102/150","I:L:V:S:A:G",13.14560022562,0.92480376844698,139.277183326525,0.094384449136949,0.0001628371344461,NA,1.28804840845689,0.0292235860951597,1.53426649183163,0.91081598550184,Inf,0.0296198560706035,"lineage2","other_mutations_pyrazinamide","ALA",0,"SAMN03653223,SRS935957","SRR2024917","lineage2.2.1","cn","China","pnca_p.val180ala","A","-","VAL","VA180","pnca_complex.pdb"
|
|
"V180A","L2","PZA","V","V180",180,"A",NA,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",15.436,-1.661,-2.048,2.8049,-2.408,-1.98,-8,53,-0.509,7,7,6,0.0344827586206896,"loop",-0.0333333333333332,5.26,0.0001437401178668,19.411022297013,511754.463552312,Inf,4.73122070382274,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-2,0,-4,0,2,0,2,5,-0.420719351570415,-0.529198966408269,0.102160563523918,-0.410571184995737,-0.518324607329843,-0.0860215053763441,-0.419275123558484,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","neutral",-0.674,-0.411,"7:7","102/150","I:L:V:S:A:G",13.14560022562,0.92480376844698,139.277183326525,0.094384449136949,0.0001628371344461,NA,1.28804840845689,0.0292235860951597,1.53426649183163,0.91081598550184,Inf,0.0296198560706035,"lineage2","other_mutations_pyrazinamide","ALA",0,"SRS935989,SAMN03653245","SRR2024941","lineage2.2.1","cn","China","pnca_p.val180ala","A","-","VAL","VA180","pnca_complex.pdb"
|
|
"V180A","L4","PZA","V","V180",180,"A",1,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",15.436,-1.661,-2.048,2.8049,-2.408,-1.98,-8,53,-0.509,7,7,6,0.0344827586206896,"loop",-0.0333333333333332,5.26,0.0001437401178668,19.411022297013,511754.463552312,Inf,4.73122070382274,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-2,0,-4,0,2,0,2,5,-0.420719351570415,-0.529198966408269,0.102160563523918,-0.410571184995737,-0.518324607329843,-0.0860215053763441,-0.419275123558484,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","neutral",-0.674,-0.411,"7:7","102/150","I:L:V:S:A:G",13.14560022562,0.92480376844698,139.277183326525,0.094384449136949,0.0001628371344461,NA,1.28804840845689,0.0292235860951597,1.53426649183163,0.91081598550184,Inf,0.0296198560706035,"lineage4","other_mutations_pyrazinamide","ALA",0,"ERR2510538","ERR2510538","lineage4.2.1","pk","Pakistan","pnca_p.val180ala","A","-","VAL","VA180","pnca_complex.pdb"
|
|
"V180A","L2","PZA","V","V180",180,"A",NA,"MDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",15.436,-1.661,-2.048,2.8049,-2.408,-1.98,-8,53,-0.509,7,7,6,0.0344827586206896,"loop",-0.0333333333333332,5.26,0.0001437401178668,19.411022297013,511754.463552312,Inf,4.73122070382274,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-2,0,-4,0,2,0,2,5,-0.420719351570415,-0.529198966408269,0.102160563523918,-0.410571184995737,-0.518324607329843,-0.0860215053763441,-0.419275123558484,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","neutral",-0.674,-0.411,"7:7","102/150","I:L:V:S:A:G",13.14560022562,0.92480376844698,139.277183326525,0.094384449136949,0.0001628371344461,NA,1.28804840845689,0.0292235860951597,1.53426649183163,0.91081598550184,Inf,0.0296198560706035,"lineage2","other_mutations_pyrazinamide","ALA",0,"ERR234115","ERR234115","lineage2.2.1","cn","China","pnca_p.val180ala","A","-","VAL","VA180","pnca_complex.pdb"
|
|
"V180F","L1","PZA","V","V180",180,"F",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",15.436,-1.073,-1.808,10.5926,-3.033,-1.23,57,75,-0.509,7,7,6,0.0344827586206896,"loop",-0.0333333333333332,5.26,0.0005749604714675,14.5802781289507,14.5802277940117,14.5801759034061,15.0663448164144,-22,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-10,0,-6,-8,-12,0,-12,-4,-0.271783181357649,-0.4671834625323,0.385805549282847,-0.517135549872123,-0.321989528795811,0.6,-0.419275123558484,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.674,-0.411,"7:7","102/150","I:L:V:S:A:G",2.6796663501904,0.0010245352377103,0.816050632122415,3.28370108999367,3.35697961122208,99.5538692592325,1.16376580853041,0.0005075351447614,3.29453387923245,2.60435121163486,147.676327006136,0.0001037975122989,"lineage1","dr_mutations_pyrazinamide","PHE",0,"SRR8380946","SRR8380946","lineage1.1.2","in","India","pnca_p.val180phe","A","-","VAL","VA180","pnca_complex.pdb"
|
|
"V180F","L4","PZA","V","V180",180,"F",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",15.436,-1.073,-1.808,10.5926,-3.033,-1.23,57,75,-0.509,7,7,6,0.0344827586206896,"loop",-0.0333333333333332,5.26,0.0005749604714675,14.5802781289507,14.5802277940117,14.5801759034061,15.0663448164144,-22,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-10,0,-6,-8,-12,0,-12,-4,-0.271783181357649,-0.4671834625323,0.385805549282847,-0.517135549872123,-0.321989528795811,0.6,-0.419275123558484,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.674,-0.411,"7:7","102/150","I:L:V:S:A:G",2.6796663501904,0.0010245352377103,0.816050632122415,3.28370108999367,3.35697961122208,99.5538692592325,1.16376580853041,0.0005075351447614,3.29453387923245,2.60435121163486,147.676327006136,0.0001037975122989,"lineage4","dr_mutations_pyrazinamide","PHE",0,"ERR751466","ERR751466","lineage4.1.1.3","pe","","pnca_p.val180phe","A","-","VAL","VA180","pnca_complex.pdb"
|
|
"V180F","L4","PZA","V","V180",180,"F",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",15.436,-1.073,-1.808,10.5926,-3.033,-1.23,57,75,-0.509,7,7,6,0.0344827586206896,"loop",-0.0333333333333332,5.26,0.0005749604714675,14.5802781289507,14.5802277940117,14.5801759034061,15.0663448164144,-22,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-10,0,-6,-8,-12,0,-12,-4,-0.271783181357649,-0.4671834625323,0.385805549282847,-0.517135549872123,-0.321989528795811,0.6,-0.419275123558484,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.674,-0.411,"7:7","102/150","I:L:V:S:A:G",2.6796663501904,0.0010245352377103,0.816050632122415,3.28370108999367,3.35697961122208,99.5538692592325,1.16376580853041,0.0005075351447614,3.29453387923245,2.60435121163486,147.676327006136,0.0001037975122989,"lineage4","dr_mutations_pyrazinamide","PHE",0,"ERR1199137","ERR1199137","lineage4.6.1.2","ug","Uganda","pnca_p.val180phe","A","-","VAL","VA180","pnca_complex.pdb"
|
|
"V180F","L5","PZA","V","V180",180,"F",1,"Pre-MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",15.436,-1.073,-1.808,10.5926,-3.033,-1.23,57,75,-0.509,7,7,6,0.0344827586206896,"loop",-0.0333333333333332,5.26,0.0005749604714675,14.5802781289507,14.5802277940117,14.5801759034061,15.0663448164144,-22,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-10,0,-6,-8,-12,0,-12,-4,-0.271783181357649,-0.4671834625323,0.385805549282847,-0.517135549872123,-0.321989528795811,0.6,-0.419275123558484,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.674,-0.411,"7:7","102/150","I:L:V:S:A:G",2.6796663501904,0.0010245352377103,0.816050632122415,3.28370108999367,3.35697961122208,99.5538692592325,1.16376580853041,0.0005075351447614,3.29453387923245,2.60435121163486,147.676327006136,0.0001037975122989,"lineage5","dr_mutations_pyrazinamide","PHE",0,"8868-03,ERS458043,ERR552427","ERR552427","lineage5","","","pnca_p.val180phe","A","-","VAL","VA180","pnca_complex.pdb"
|
|
"V180F","L2","PZA","V","V180",180,"F",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",15.436,-1.073,-1.808,10.5926,-3.033,-1.23,57,75,-0.509,7,7,6,0.0344827586206896,"loop",-0.0333333333333332,5.26,0.0005749604714675,14.5802781289507,14.5802277940117,14.5801759034061,15.0663448164144,-22,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-10,0,-6,-8,-12,0,-12,-4,-0.271783181357649,-0.4671834625323,0.385805549282847,-0.517135549872123,-0.321989528795811,0.6,-0.419275123558484,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.674,-0.411,"7:7","102/150","I:L:V:S:A:G",2.6796663501904,0.0010245352377103,0.816050632122415,3.28370108999367,3.35697961122208,99.5538692592325,1.16376580853041,0.0005075351447614,3.29453387923245,2.60435121163486,147.676327006136,0.0001037975122989,"lineage2","dr_mutations_pyrazinamide","PHE",0,"ERR3335742","ERR3335742","lineage2.2.1","pk","Pakistan","pnca_p.val180phe","A","-","VAL","VA180","pnca_complex.pdb"
|
|
"V180F","L2","PZA","V","V180",180,"F",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",15.436,-1.073,-1.808,10.5926,-3.033,-1.23,57,75,-0.509,7,7,6,0.0344827586206896,"loop",-0.0333333333333332,5.26,0.0005749604714675,14.5802781289507,14.5802277940117,14.5801759034061,15.0663448164144,-22,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-10,0,-6,-8,-12,0,-12,-4,-0.271783181357649,-0.4671834625323,0.385805549282847,-0.517135549872123,-0.321989528795811,0.6,-0.419275123558484,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.674,-0.411,"7:7","102/150","I:L:V:S:A:G",2.6796663501904,0.0010245352377103,0.816050632122415,3.28370108999367,3.35697961122208,99.5538692592325,1.16376580853041,0.0005075351447614,3.29453387923245,2.60435121163486,147.676327006136,0.0001037975122989,"lineage2","dr_mutations_pyrazinamide","PHE",0,"ERR3335738","ERR3335738","lineage2.2.1","pk","Pakistan","pnca_p.val180phe","A","-","VAL","VA180","pnca_complex.pdb"
|
|
"V180F","L2","PZA","V","V180",180,"F",1,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",15.436,-1.073,-1.808,10.5926,-3.033,-1.23,57,75,-0.509,7,7,6,0.0344827586206896,"loop",-0.0333333333333332,5.26,0.0005749604714675,14.5802781289507,14.5802277940117,14.5801759034061,15.0663448164144,-22,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-10,0,-6,-8,-12,0,-12,-4,-0.271783181357649,-0.4671834625323,0.385805549282847,-0.517135549872123,-0.321989528795811,0.6,-0.419275123558484,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.674,-0.411,"7:7","102/150","I:L:V:S:A:G",2.6796663501904,0.0010245352377103,0.816050632122415,3.28370108999367,3.35697961122208,99.5538692592325,1.16376580853041,0.0005075351447614,3.29453387923245,2.60435121163486,147.676327006136,0.0001037975122989,"lineage2","dr_mutations_pyrazinamide","PHE",0,"ERR3335791","ERR3335791","lineage2.2.1","pk","Pakistan","pnca_p.val180phe","A","-","VAL","VA180","pnca_complex.pdb"
|
|
"V180F","L3","PZA","V","V180",180,"F",1,"MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",15.436,-1.073,-1.808,10.5926,-3.033,-1.23,57,75,-0.509,7,7,6,0.0344827586206896,"loop",-0.0333333333333332,5.26,0.0005749604714675,14.5802781289507,14.5802277940117,14.5801759034061,15.0663448164144,-22,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-10,0,-6,-8,-12,0,-12,-4,-0.271783181357649,-0.4671834625323,0.385805549282847,-0.517135549872123,-0.321989528795811,0.6,-0.419275123558484,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.674,-0.411,"7:7","102/150","I:L:V:S:A:G",2.6796663501904,0.0010245352377103,0.816050632122415,3.28370108999367,3.35697961122208,99.5538692592325,1.16376580853041,0.0005075351447614,3.29453387923245,2.60435121163486,147.676327006136,0.0001037975122989,"lineage3","dr_mutations_pyrazinamide","PHE",0,"ERR2510503","ERR2510503","lineage3","pk","Pakistan","pnca_p.val180phe","A","-","VAL","VA180","pnca_complex.pdb"
|
|
"V180F","L4","PZA","V","V180",180,"F",0,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",15.436,-1.073,-1.808,10.5926,-3.033,-1.23,57,75,-0.509,7,7,6,0.0344827586206896,"loop",-0.0333333333333332,5.26,0.0005749604714675,14.5802781289507,14.5802277940117,14.5801759034061,15.0663448164144,-22,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-10,0,-6,-8,-12,0,-12,-4,-0.271783181357649,-0.4671834625323,0.385805549282847,-0.517135549872123,-0.321989528795811,0.6,-0.419275123558484,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.674,-0.411,"7:7","102/150","I:L:V:S:A:G",2.6796663501904,0.0010245352377103,0.816050632122415,3.28370108999367,3.35697961122208,99.5538692592325,1.16376580853041,0.0005075351447614,3.29453387923245,2.60435121163486,147.676327006136,0.0001037975122989,"lineage4","dr_mutations_pyrazinamide","PHE",0,"ERR2510306","ERR2510306","lineage4.2.2","pk","Pakistan","pnca_p.val180phe","A","-","VAL","VA180","pnca_complex.pdb"
|
|
"V180F","L2","PZA","V","V180",180,"F",NA,"MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",15.436,-1.073,-1.808,10.5926,-3.033,-1.23,57,75,-0.509,7,7,6,0.0344827586206896,"loop",-0.0333333333333332,5.26,0.0005749604714675,14.5802781289507,14.5802277940117,14.5801759034061,15.0663448164144,-22,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-10,0,-6,-8,-12,0,-12,-4,-0.271783181357649,-0.4671834625323,0.385805549282847,-0.517135549872123,-0.321989528795811,0.6,-0.419275123558484,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.674,-0.411,"7:7","102/150","I:L:V:S:A:G",2.6796663501904,0.0010245352377103,0.816050632122415,3.28370108999367,3.35697961122208,99.5538692592325,1.16376580853041,0.0005075351447614,3.29453387923245,2.60435121163486,147.676327006136,0.0001037975122989,"lineage2","dr_mutations_pyrazinamide","PHE",0,"ERR552934","ERR552934","lineage2.2.1","cg","Congo","pnca_p.val180phe","A","-","VAL","VA180","pnca_complex.pdb"
|
|
"V180F","L2","PZA","V","V180",180,"F",1,"MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",15.436,-1.073,-1.808,10.5926,-3.033,-1.23,57,75,-0.509,7,7,6,0.0344827586206896,"loop",-0.0333333333333332,5.26,0.0005749604714675,14.5802781289507,14.5802277940117,14.5801759034061,15.0663448164144,-22,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-10,0,-6,-8,-12,0,-12,-4,-0.271783181357649,-0.4671834625323,0.385805549282847,-0.517135549872123,-0.321989528795811,0.6,-0.419275123558484,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.674,-0.411,"7:7","102/150","I:L:V:S:A:G",2.6796663501904,0.0010245352377103,0.816050632122415,3.28370108999367,3.35697961122208,99.5538692592325,1.16376580853041,0.0005075351447614,3.29453387923245,2.60435121163486,147.676327006136,0.0001037975122989,"lineage2","dr_mutations_pyrazinamide","PHE",0,"ERR3335798","ERR3335798","lineage2.2.1","pk","Pakistan","pnca_p.val180phe","A","-","VAL","VA180","pnca_complex.pdb"
|
|
"V180F","L2","PZA","V","V180",180,"F",1,"MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",15.436,-1.073,-1.808,10.5926,-3.033,-1.23,57,75,-0.509,7,7,6,0.0344827586206896,"loop",-0.0333333333333332,5.26,0.0005749604714675,14.5802781289507,14.5802277940117,14.5801759034061,15.0663448164144,-22,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-10,0,-6,-8,-12,0,-12,-4,-0.271783181357649,-0.4671834625323,0.385805549282847,-0.517135549872123,-0.321989528795811,0.6,-0.419275123558484,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.674,-0.411,"7:7","102/150","I:L:V:S:A:G",2.6796663501904,0.0010245352377103,0.816050632122415,3.28370108999367,3.35697961122208,99.5538692592325,1.16376580853041,0.0005075351447614,3.29453387923245,2.60435121163486,147.676327006136,0.0001037975122989,"lineage2","dr_mutations_pyrazinamide","PHE",0,"ERR038746","ERR038746","lineage2.2.1","ug","Uganda","pnca_p.val180phe","A","-","VAL","VA180","pnca_complex.pdb"
|
|
"V180F","L2","PZA","V","V180",180,"F",0,"MDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",15.436,-1.073,-1.808,10.5926,-3.033,-1.23,57,75,-0.509,7,7,6,0.0344827586206896,"loop",-0.0333333333333332,5.26,0.0005749604714675,14.5802781289507,14.5802277940117,14.5801759034061,15.0663448164144,-22,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-10,0,-6,-8,-12,0,-12,-4,-0.271783181357649,-0.4671834625323,0.385805549282847,-0.517135549872123,-0.321989528795811,0.6,-0.419275123558484,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.674,-0.411,"7:7","102/150","I:L:V:S:A:G",2.6796663501904,0.0010245352377103,0.816050632122415,3.28370108999367,3.35697961122208,99.5538692592325,1.16376580853041,0.0005075351447614,3.29453387923245,2.60435121163486,147.676327006136,0.0001037975122989,"lineage2","dr_mutations_pyrazinamide","PHE",0,"MDR_1135","SRR6824447","lineage2.2.1","cn","China: Huairou District, Beijing","pnca_p.val180phe","A","-","VAL","VA180","pnca_complex.pdb"
|
|
"V180F","L3","PZA","V","V180",180,"F",1,"XDR","DM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",15.436,-1.073,-1.808,10.5926,-3.033,-1.23,57,75,-0.509,7,7,6,0.0344827586206896,"loop",-0.0333333333333332,5.26,0.0005749604714675,14.5802781289507,14.5802277940117,14.5801759034061,15.0663448164144,-22,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-10,0,-6,-8,-12,0,-12,-4,-0.271783181357649,-0.4671834625323,0.385805549282847,-0.517135549872123,-0.321989528795811,0.6,-0.419275123558484,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.674,-0.411,"7:7","102/150","I:L:V:S:A:G",2.6796663501904,0.0010245352377103,0.816050632122415,3.28370108999367,3.35697961122208,99.5538692592325,1.16376580853041,0.0005075351447614,3.29453387923245,2.60435121163486,147.676327006136,0.0001037975122989,"lineage3","dr_mutations_pyrazinamide","PHE",0,"ERR2510399","ERR2510399","lineage3","pk","Pakistan","pnca_p.val180phe","A","-","VAL","VA180","pnca_complex.pdb"
|
|
"V180G","L2","PZA","V","V180",180,"G",1,"XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",15.436,-1.577,-2.785,4.93179,-3.447,-2.32,61,80,-0.509,7,7,6,0.0344827586206896,"loop",-0.0333333333333332,5.26,0.0007905706482679,107.166385135135,3795803.48339175,Inf,47.6847963834956,12,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-4,0,-6,0,6,0,13,23,-0.399442755825735,-0.719638242894057,0.17962652699976,-0.58772378516624,-0.607329842931937,0.642105263157895,-0.419275123558484,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.674,-0.411,"7:7","102/150","I:L:V:S:A:G",15.1494066679809,0.92523341791644,161.432542879438,0.0938435732830823,24.1993753459118,NA,2.03005858162844,3.58120158191569e-09,8.44597123233921,12.2081619622864,Inf,5.00558510128865e-12,"lineage2","dr_mutations_pyrazinamide","GLY",0,"ERR229982,2395E-sc-2012-10-11T13:40:00Z-1494301","ERR229982","lineage2.2.1","ru","Russia,Samara","pnca_p.val180gly","A","-","VAL","VA180","pnca_complex.pdb"
|
|
"V180G","L2","PZA","V","V180",180,"G",1,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",15.436,-1.577,-2.785,4.93179,-3.447,-2.32,61,80,-0.509,7,7,6,0.0344827586206896,"loop",-0.0333333333333332,5.26,0.0007905706482679,107.166385135135,3795803.48339175,Inf,47.6847963834956,12,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-4,0,-6,0,6,0,13,23,-0.399442755825735,-0.719638242894057,0.17962652699976,-0.58772378516624,-0.607329842931937,0.642105263157895,-0.419275123558484,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.674,-0.411,"7:7","102/150","I:L:V:S:A:G",15.1494066679809,0.92523341791644,161.432542879438,0.0938435732830823,24.1993753459118,NA,2.03005858162844,3.58120158191569e-09,8.44597123233921,12.2081619622864,Inf,5.00558510128865e-12,"lineage2","dr_mutations_pyrazinamide","GLY",0,"ERS456865","ERR550779_ERR550777_ERR550778","lineage2.2.1","uz","Nukus","pnca_p.val180gly","A","-","VAL","VA180","pnca_complex.pdb"
|
|
"V180G","L4","PZA","V","V180",180,"G",1,"XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",15.436,-1.577,-2.785,4.93179,-3.447,-2.32,61,80,-0.509,7,7,6,0.0344827586206896,"loop",-0.0333333333333332,5.26,0.0007905706482679,107.166385135135,3795803.48339175,Inf,47.6847963834956,12,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-4,0,-6,0,6,0,13,23,-0.399442755825735,-0.719638242894057,0.17962652699976,-0.58772378516624,-0.607329842931937,0.642105263157895,-0.419275123558484,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.674,-0.411,"7:7","102/150","I:L:V:S:A:G",15.1494066679809,0.92523341791644,161.432542879438,0.0938435732830823,24.1993753459118,NA,2.03005858162844,3.58120158191569e-09,8.44597123233921,12.2081619622864,Inf,5.00558510128865e-12,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR2510730","ERR2510730","lineage4.8","it","Italy","pnca_p.val180gly","A","-","VAL","VA180","pnca_complex.pdb"
|
|
"V180G","L2","PZA","V","V180",180,"G",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",15.436,-1.577,-2.785,4.93179,-3.447,-2.32,61,80,-0.509,7,7,6,0.0344827586206896,"loop",-0.0333333333333332,5.26,0.0007905706482679,107.166385135135,3795803.48339175,Inf,47.6847963834956,12,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-4,0,-6,0,6,0,13,23,-0.399442755825735,-0.719638242894057,0.17962652699976,-0.58772378516624,-0.607329842931937,0.642105263157895,-0.419275123558484,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.674,-0.411,"7:7","102/150","I:L:V:S:A:G",15.1494066679809,0.92523341791644,161.432542879438,0.0938435732830823,24.1993753459118,NA,2.03005858162844,3.58120158191569e-09,8.44597123233921,12.2081619622864,Inf,5.00558510128865e-12,"lineage2","dr_mutations_pyrazinamide","GLY",0,"ERR230009","ERR230009","lineage2.2.1","ru","Russia","pnca_p.val180gly","A","-","VAL","VA180","pnca_complex.pdb"
|
|
"V180G","L4","PZA","V","V180",180,"G",1,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",15.436,-1.577,-2.785,4.93179,-3.447,-2.32,61,80,-0.509,7,7,6,0.0344827586206896,"loop",-0.0333333333333332,5.26,0.0007905706482679,107.166385135135,3795803.48339175,Inf,47.6847963834956,12,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-4,0,-6,0,6,0,13,23,-0.399442755825735,-0.719638242894057,0.17962652699976,-0.58772378516624,-0.607329842931937,0.642105263157895,-0.419275123558484,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.674,-0.411,"7:7","102/150","I:L:V:S:A:G",15.1494066679809,0.92523341791644,161.432542879438,0.0938435732830823,24.1993753459118,NA,2.03005858162844,3.58120158191569e-09,8.44597123233921,12.2081619622864,Inf,5.00558510128865e-12,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR2516650","ERR2516650","lineage4","pe","Peru","pnca_p.val180gly","A","-","VAL","VA180","pnca_complex.pdb"
|
|
"V180G","L1","PZA","V","V180",180,"G",1,"MDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",15.436,-1.577,-2.785,4.93179,-3.447,-2.32,61,80,-0.509,7,7,6,0.0344827586206896,"loop",-0.0333333333333332,5.26,0.0007905706482679,107.166385135135,3795803.48339175,Inf,47.6847963834956,12,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-4,0,-6,0,6,0,13,23,-0.399442755825735,-0.719638242894057,0.17962652699976,-0.58772378516624,-0.607329842931937,0.642105263157895,-0.419275123558484,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.674,-0.411,"7:7","102/150","I:L:V:S:A:G",15.1494066679809,0.92523341791644,161.432542879438,0.0938435732830823,24.1993753459118,NA,2.03005858162844,3.58120158191569e-09,8.44597123233921,12.2081619622864,Inf,5.00558510128865e-12,"lineage1","dr_mutations_pyrazinamide","GLY",0,"SRR6369876","SRR6369876","lineage1.1.1","au","Australia","pnca_p.val180gly","A","-","VAL","VA180","pnca_complex.pdb"
|
|
"V180G","L2","PZA","V","V180",180,"G",1,"XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",15.436,-1.577,-2.785,4.93179,-3.447,-2.32,61,80,-0.509,7,7,6,0.0344827586206896,"loop",-0.0333333333333332,5.26,0.0007905706482679,107.166385135135,3795803.48339175,Inf,47.6847963834956,12,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-4,0,-6,0,6,0,13,23,-0.399442755825735,-0.719638242894057,0.17962652699976,-0.58772378516624,-0.607329842931937,0.642105263157895,-0.419275123558484,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.674,-0.411,"7:7","102/150","I:L:V:S:A:G",15.1494066679809,0.92523341791644,161.432542879438,0.0938435732830823,24.1993753459118,NA,2.03005858162844,3.58120158191569e-09,8.44597123233921,12.2081619622864,Inf,5.00558510128865e-12,"lineage2","dr_mutations_pyrazinamide","GLY",0,"ERR234600,0539M-sc-2012-10-11T13:36:33Z-1494086","ERR234600","lineage2.2.1","ru","Russia,Samara","pnca_p.val180gly","A","-","VAL","VA180","pnca_complex.pdb"
|
|
"V180G","L2","PZA","V","V180",180,"G",1,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",15.436,-1.577,-2.785,4.93179,-3.447,-2.32,61,80,-0.509,7,7,6,0.0344827586206896,"loop",-0.0333333333333332,5.26,0.0007905706482679,107.166385135135,3795803.48339175,Inf,47.6847963834956,12,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-4,0,-6,0,6,0,13,23,-0.399442755825735,-0.719638242894057,0.17962652699976,-0.58772378516624,-0.607329842931937,0.642105263157895,-0.419275123558484,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.674,-0.411,"7:7","102/150","I:L:V:S:A:G",15.1494066679809,0.92523341791644,161.432542879438,0.0938435732830823,24.1993753459118,NA,2.03005858162844,3.58120158191569e-09,8.44597123233921,12.2081619622864,Inf,5.00558510128865e-12,"lineage2","dr_mutations_pyrazinamide","GLY",0,"SAMEA2534582,ERS457984","ERR552346_ERR552347","lineage2.2.1","uz","Nukus","pnca_p.val180gly","A","-","VAL","VA180","pnca_complex.pdb"
|
|
"V180G","L2","PZA","V","V180",180,"G",1,"XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",15.436,-1.577,-2.785,4.93179,-3.447,-2.32,61,80,-0.509,7,7,6,0.0344827586206896,"loop",-0.0333333333333332,5.26,0.0007905706482679,107.166385135135,3795803.48339175,Inf,47.6847963834956,12,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-4,0,-6,0,6,0,13,23,-0.399442755825735,-0.719638242894057,0.17962652699976,-0.58772378516624,-0.607329842931937,0.642105263157895,-0.419275123558484,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.674,-0.411,"7:7","102/150","I:L:V:S:A:G",15.1494066679809,0.92523341791644,161.432542879438,0.0938435732830823,24.1993753459118,NA,2.03005858162844,3.58120158191569e-09,8.44597123233921,12.2081619622864,Inf,5.00558510128865e-12,"lineage2","dr_mutations_pyrazinamide","GLY",0,"ERR133879,0530C-sc-2012-02-09T18:56:20Z-1355212","ERR133879","lineage2.2.1","ru","Russia,Samara","pnca_p.val180gly","A","-","VAL","VA180","pnca_complex.pdb"
|
|
"V180G","L4","PZA","V","V180",180,"G",1,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",15.436,-1.577,-2.785,4.93179,-3.447,-2.32,61,80,-0.509,7,7,6,0.0344827586206896,"loop",-0.0333333333333332,5.26,0.0007905706482679,107.166385135135,3795803.48339175,Inf,47.6847963834956,12,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-4,0,-6,0,6,0,13,23,-0.399442755825735,-0.719638242894057,0.17962652699976,-0.58772378516624,-0.607329842931937,0.642105263157895,-0.419275123558484,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.674,-0.411,"7:7","102/150","I:L:V:S:A:G",15.1494066679809,0.92523341791644,161.432542879438,0.0938435732830823,24.1993753459118,NA,2.03005858162844,3.58120158191569e-09,8.44597123233921,12.2081619622864,Inf,5.00558510128865e-12,"lineage4","dr_mutations_pyrazinamide","GLY",0,"ERR2516503","ERR2516503","lineage4","pe","Peru","pnca_p.val180gly","A","-","VAL","VA180","pnca_complex.pdb"
|
|
"V180G","L2","PZA","V","V180",180,"G",1,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",15.436,-1.577,-2.785,4.93179,-3.447,-2.32,61,80,-0.509,7,7,6,0.0344827586206896,"loop",-0.0333333333333332,5.26,0.0007905706482679,107.166385135135,3795803.48339175,Inf,47.6847963834956,12,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-4,0,-6,0,6,0,13,23,-0.399442755825735,-0.719638242894057,0.17962652699976,-0.58772378516624,-0.607329842931937,0.642105263157895,-0.419275123558484,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.674,-0.411,"7:7","102/150","I:L:V:S:A:G",15.1494066679809,0.92523341791644,161.432542879438,0.0938435732830823,24.1993753459118,NA,2.03005858162844,3.58120158191569e-09,8.44597123233921,12.2081619622864,Inf,5.00558510128865e-12,"lineage2","dr_mutations_pyrazinamide","GLY",0,"ERS2592782","ERR2677436","lineage2.2.1","de","Germany","pnca_p.val180gly","A","-","VAL","VA180","pnca_complex.pdb"
|
|
"V180G","L2","PZA","V","V180",180,"G",1,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",15.436,-1.577,-2.785,4.93179,-3.447,-2.32,61,80,-0.509,7,7,6,0.0344827586206896,"loop",-0.0333333333333332,5.26,0.0007905706482679,107.166385135135,3795803.48339175,Inf,47.6847963834956,12,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-4,0,-6,0,6,0,13,23,-0.399442755825735,-0.719638242894057,0.17962652699976,-0.58772378516624,-0.607329842931937,0.642105263157895,-0.419275123558484,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.674,-0.411,"7:7","102/150","I:L:V:S:A:G",15.1494066679809,0.92523341791644,161.432542879438,0.0938435732830823,24.1993753459118,NA,2.03005858162844,3.58120158191569e-09,8.44597123233921,12.2081619622864,Inf,5.00558510128865e-12,"lineage2","dr_mutations_pyrazinamide","GLY",0,"2498R-sc-2012-10-11T13:39:48Z-1494288,ERR229969","ERR229969","lineage2.2.1","ru","Russia,Samara","pnca_p.val180gly","A","-","VAL","VA180","pnca_complex.pdb"
|
|
"V180G","L2","PZA","V","V180",180,"G",NA,"Pre-XDR","DM","hydrophobic","hydrophobic","non-polar","neutral","non-polar","non-polar",15.436,-1.577,-2.785,4.93179,-3.447,-2.32,61,80,-0.509,7,7,6,0.0344827586206896,"loop",-0.0333333333333332,5.26,0.0007905706482679,107.166385135135,3795803.48339175,Inf,47.6847963834956,12,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-4,0,-6,0,6,0,13,23,-0.399442755825735,-0.719638242894057,0.17962652699976,-0.58772378516624,-0.607329842931937,0.642105263157895,-0.419275123558484,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.674,-0.411,"7:7","102/150","I:L:V:S:A:G",15.1494066679809,0.92523341791644,161.432542879438,0.0938435732830823,24.1993753459118,NA,2.03005858162844,3.58120158191569e-09,8.44597123233921,12.2081619622864,Inf,5.00558510128865e-12,"lineage2","dr_mutations_pyrazinamide","GLY",0,"ERR067628","ERR067628","lineage2.2.1","ru","Russia","pnca_p.val180gly","A","-","VAL","VA180","pnca_complex.pdb"
|
|
"V180L","L2","PZA","V","V180",180,"L",NA,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",15.436,-1.664,-0.877,-0.0108685,-2.269,-0.8,56,75,-0.509,7,7,6,0.0344827586206896,"loop",-0.0333333333333332,5.26,NA,NA,NA,NA,NA,-16,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-9,0,-2,-9,-10,0,-10,-2,-0.421479229989868,-0.226614987080103,-0.00208961393524571,-0.386871270247229,-0.209424083769634,0.589473684210526,-0.419275123558484,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.674,-0.411,"7:7","102/150","I:L:V:S:A:G",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage2","other_mutations_pyrazinamide","LEU",0,"1362G-sc-2012-02-21T11:36:33Z-1364711,ERR137219","ERR137219","lineage2.2.1","ru","Russia","pnca_p.val180leu","A","-","VAL","VA180","pnca_complex.pdb"
|
|
"V180L","L4","PZA","V","V180",180,"L",NA,"MDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",15.436,-1.664,-0.877,-0.0108685,-2.269,-0.8,56,75,-0.509,7,7,6,0.0344827586206896,"loop",-0.0333333333333332,5.26,NA,NA,NA,NA,NA,-16,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-9,0,-2,-9,-10,0,-10,-2,-0.421479229989868,-0.226614987080103,-0.00208961393524571,-0.386871270247229,-0.209424083769634,0.589473684210526,-0.419275123558484,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","effect",-0.674,-0.411,"7:7","102/150","I:L:V:S:A:G",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage4","other_mutations_pyrazinamide","LEU",0,"ERR1034897","ERR1034897","lineage4.2.2.1","pt","Portugal","pnca_p.val180leu","A","-","VAL","VA180","pnca_complex.pdb"
|
|
"L182F","L4","PZA","L","L182",182,"F",NA,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",15.184,-0.294,-1.168,4.99445,-0.804,-1,47,71,0.281,4,4,50,0.248756218905473,"strand",1.5,4.17,7.18700589334483e-05,2.42412778478352,0.0001249735077034,0,1.03410070803344e-29,-6,-2,0,0,-2,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,1,2,0,4,0,-0.0744680851063829,-0.301808785529716,0.181908740593973,-0.137084398976982,-0.261780104712042,0.494736842105263,0.0900641025641026,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","87/150","F:Q:L:V:R:I",-8.98740878149642,0.940032862253634,119.468044435493,-0.0752285585987741,NA,4692673.5108132,0.384555509373631,1,0,0,188.544222231268,0.999999999999997,"lineage4","other_mutations_pyrazinamide","PHE",0,"ERR2510225","ERR2510225","lineage4.3.4.2","pe","Peru","pnca_p.leu182phe","A","E","LEU","LA182","pnca_complex.pdb"
|
|
"L182F","L4","PZA","L","L182",182,"F",NA,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",15.184,-0.294,-1.168,4.99445,-0.804,-1,47,71,0.281,4,4,50,0.248756218905473,"strand",1.5,4.17,7.18700589334483e-05,2.42412778478352,0.0001249735077034,0,1.03410070803344e-29,-6,-2,0,0,-2,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,1,2,0,4,0,-0.0744680851063829,-0.301808785529716,0.181908740593973,-0.137084398976982,-0.261780104712042,0.494736842105263,0.0900641025641026,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","87/150","F:Q:L:V:R:I",-8.98740878149642,0.940032862253634,119.468044435493,-0.0752285585987741,NA,4692673.5108132,0.384555509373631,1,0,0,188.544222231268,0.999999999999997,"lineage4","other_mutations_pyrazinamide","PHE",0,"ERR751389","ERR751389","lineage4.3.4.2","pe","","pnca_p.leu182phe","A","E","LEU","LA182","pnca_complex.pdb"
|
|
"L182F","L4","PZA","L","L182",182,"F",NA,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",15.184,-0.294,-1.168,4.99445,-0.804,-1,47,71,0.281,4,4,50,0.248756218905473,"strand",1.5,4.17,7.18700589334483e-05,2.42412778478352,0.0001249735077034,0,1.03410070803344e-29,-6,-2,0,0,-2,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,1,2,0,4,0,-0.0744680851063829,-0.301808785529716,0.181908740593973,-0.137084398976982,-0.261780104712042,0.494736842105263,0.0900641025641026,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","87/150","F:Q:L:V:R:I",-8.98740878149642,0.940032862253634,119.468044435493,-0.0752285585987741,NA,4692673.5108132,0.384555509373631,1,0,0,188.544222231268,0.999999999999997,"lineage4","other_mutations_pyrazinamide","PHE",0,"ERR2510211","ERR2510211","lineage4.3.4.2","pe","Peru","pnca_p.leu182phe","A","E","LEU","LA182","pnca_complex.pdb"
|
|
"L182F","L4","PZA","L","L182",182,"F",NA,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",15.184,-0.294,-1.168,4.99445,-0.804,-1,47,71,0.281,4,4,50,0.248756218905473,"strand",1.5,4.17,7.18700589334483e-05,2.42412778478352,0.0001249735077034,0,1.03410070803344e-29,-6,-2,0,0,-2,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,1,2,0,4,0,-0.0744680851063829,-0.301808785529716,0.181908740593973,-0.137084398976982,-0.261780104712042,0.494736842105263,0.0900641025641026,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","87/150","F:Q:L:V:R:I",-8.98740878149642,0.940032862253634,119.468044435493,-0.0752285585987741,NA,4692673.5108132,0.384555509373631,1,0,0,188.544222231268,0.999999999999997,"lineage4","other_mutations_pyrazinamide","PHE",0,"ERR751544","ERR751544","lineage4.3.4.2","pe","","pnca_p.leu182phe","A","E","LEU","LA182","pnca_complex.pdb"
|
|
"L182F","L4","PZA","L","L182",182,"F",NA,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",15.184,-0.294,-1.168,4.99445,-0.804,-1,47,71,0.281,4,4,50,0.248756218905473,"strand",1.5,4.17,7.18700589334483e-05,2.42412778478352,0.0001249735077034,0,1.03410070803344e-29,-6,-2,0,0,-2,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,1,2,0,4,0,-0.0744680851063829,-0.301808785529716,0.181908740593973,-0.137084398976982,-0.261780104712042,0.494736842105263,0.0900641025641026,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","87/150","F:Q:L:V:R:I",-8.98740878149642,0.940032862253634,119.468044435493,-0.0752285585987741,NA,4692673.5108132,0.384555509373631,1,0,0,188.544222231268,0.999999999999997,"lineage4","other_mutations_pyrazinamide","PHE",0,"ERR775348","ERR775348","lineage4.3.4.2","pe","","pnca_p.leu182phe","A","E","LEU","LA182","pnca_complex.pdb"
|
|
"L182F","L4","PZA","L","L182",182,"F",NA,"MDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",15.184,-0.294,-1.168,4.99445,-0.804,-1,47,71,0.281,4,4,50,0.248756218905473,"strand",1.5,4.17,7.18700589334483e-05,2.42412778478352,0.0001249735077034,0,1.03410070803344e-29,-6,-2,0,0,-2,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,1,2,0,4,0,-0.0744680851063829,-0.301808785529716,0.181908740593973,-0.137084398976982,-0.261780104712042,0.494736842105263,0.0900641025641026,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","87/150","F:Q:L:V:R:I",-8.98740878149642,0.940032862253634,119.468044435493,-0.0752285585987741,NA,4692673.5108132,0.384555509373631,1,0,0,188.544222231268,0.999999999999997,"lineage4","other_mutations_pyrazinamide","PHE",0,"ERR779917","ERR779917","lineage4.3.4.2","pe","","pnca_p.leu182phe","A","E","LEU","LA182","pnca_complex.pdb"
|
|
"L182F","L4","PZA","L","L182",182,"F",NA,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",15.184,-0.294,-1.168,4.99445,-0.804,-1,47,71,0.281,4,4,50,0.248756218905473,"strand",1.5,4.17,7.18700589334483e-05,2.42412778478352,0.0001249735077034,0,1.03410070803344e-29,-6,-2,0,0,-2,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,1,2,0,4,0,-0.0744680851063829,-0.301808785529716,0.181908740593973,-0.137084398976982,-0.261780104712042,0.494736842105263,0.0900641025641026,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","87/150","F:Q:L:V:R:I",-8.98740878149642,0.940032862253634,119.468044435493,-0.0752285585987741,NA,4692673.5108132,0.384555509373631,1,0,0,188.544222231268,0.999999999999997,"lineage4","other_mutations_pyrazinamide","PHE",0,"ERR779908","ERR779908","lineage4.3.4.2","pe","","pnca_p.leu182phe","A","E","LEU","LA182","pnca_complex.pdb"
|
|
"L182F","L4","PZA","L","L182",182,"F",0,"XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",15.184,-0.294,-1.168,4.99445,-0.804,-1,47,71,0.281,4,4,50,0.248756218905473,"strand",1.5,4.17,7.18700589334483e-05,2.42412778478352,0.0001249735077034,0,1.03410070803344e-29,-6,-2,0,0,-2,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,1,2,0,4,0,-0.0744680851063829,-0.301808785529716,0.181908740593973,-0.137084398976982,-0.261780104712042,0.494736842105263,0.0900641025641026,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","87/150","F:Q:L:V:R:I",-8.98740878149642,0.940032862253634,119.468044435493,-0.0752285585987741,NA,4692673.5108132,0.384555509373631,1,0,0,188.544222231268,0.999999999999997,"lineage4","other_mutations_pyrazinamide","PHE",0,"ERR2516662","ERR2516662","lineage4.3.4.2","pe","Peru","pnca_p.leu182phe","A","E","LEU","LA182","pnca_complex.pdb"
|
|
"L182S","L2","PZA","L","L182",182,"S",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",15.184,0.38,-2.349,5.37676,-1.864,-1.98,71,85,0.281,4,4,50,0.248756218905473,"strand",1.5,4.17,0.0007187005893344,4.85678180286436,4.85678176777767,4.85605251831648,5.49640065724654,22,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-1,0,-1,0,4,0,4,2,0.170403587443946,-0.606976744186047,0.195833302981519,-0.317817561807332,-0.518324607329843,0.747368421052632,0.0900641025641026,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","87/150","F:Q:L:V:R:I",1.58037603086922,0.0125175169650379,0.632856943325042,2.49720896252777,1.34977418228528,17.4757677148671,0.686348592676127,0.0171758041796076,1.76508291991092,1.11658950345066,21.1173440246382,0.0190556572462216,"lineage2","dr_mutations_pyrazinamide","SER",0,"ERR2516229","ERR2516229","lineage2.2.1","be","Belgium","pnca_p.leu182ser","A","E","LEU","LA182","pnca_complex.pdb"
|
|
"L182S","L2","PZA","L","L182",182,"S",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",15.184,0.38,-2.349,5.37676,-1.864,-1.98,71,85,0.281,4,4,50,0.248756218905473,"strand",1.5,4.17,0.0007187005893344,4.85678180286436,4.85678176777767,4.85605251831648,5.49640065724654,22,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-1,0,-1,0,4,0,4,2,0.170403587443946,-0.606976744186047,0.195833302981519,-0.317817561807332,-0.518324607329843,0.747368421052632,0.0900641025641026,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","87/150","F:Q:L:V:R:I",1.58037603086922,0.0125175169650379,0.632856943325042,2.49720896252777,1.34977418228528,17.4757677148671,0.686348592676127,0.0171758041796076,1.76508291991092,1.11658950345066,21.1173440246382,0.0190556572462216,"lineage2","dr_mutations_pyrazinamide","SER",0,"ERR1023407","ERR1023407","lineage2.2.1","","","pnca_p.leu182ser","A","E","LEU","LA182","pnca_complex.pdb"
|
|
"L182S","L2","PZA","L","L182",182,"S",0,"Pre-XDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",15.184,0.38,-2.349,5.37676,-1.864,-1.98,71,85,0.281,4,4,50,0.248756218905473,"strand",1.5,4.17,0.0007187005893344,4.85678180286436,4.85678176777767,4.85605251831648,5.49640065724654,22,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-1,0,-1,0,4,0,4,2,0.170403587443946,-0.606976744186047,0.195833302981519,-0.317817561807332,-0.518324607329843,0.747368421052632,0.0900641025641026,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","87/150","F:Q:L:V:R:I",1.58037603086922,0.0125175169650379,0.632856943325042,2.49720896252777,1.34977418228528,17.4757677148671,0.686348592676127,0.0171758041796076,1.76508291991092,1.11658950345066,21.1173440246382,0.0190556572462216,"lineage2","dr_mutations_pyrazinamide","SER",0,"ERS457564","ERR551745_ERR551743_ERR551744","lineage2.2.1","uz","Nukus","pnca_p.leu182ser","A","E","LEU","LA182","pnca_complex.pdb"
|
|
"L182S","L2","PZA","L","L182",182,"S",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",15.184,0.38,-2.349,5.37676,-1.864,-1.98,71,85,0.281,4,4,50,0.248756218905473,"strand",1.5,4.17,0.0007187005893344,4.85678180286436,4.85678176777767,4.85605251831648,5.49640065724654,22,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-1,0,-1,0,4,0,4,2,0.170403587443946,-0.606976744186047,0.195833302981519,-0.317817561807332,-0.518324607329843,0.747368421052632,0.0900641025641026,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","87/150","F:Q:L:V:R:I",1.58037603086922,0.0125175169650379,0.632856943325042,2.49720896252777,1.34977418228528,17.4757677148671,0.686348592676127,0.0171758041796076,1.76508291991092,1.11658950345066,21.1173440246382,0.0190556572462216,"lineage2","dr_mutations_pyrazinamide","SER",0,"SAMN02414932","SRR1163306_SRR1163459_SRR1146339_SRR1144772","lineage2.2.1","se","Sweden","pnca_p.leu182ser","A","E","LEU","LA182","pnca_complex.pdb"
|
|
"L182S","L2","PZA","L","L182",182,"S",0,"Pre-MDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",15.184,0.38,-2.349,5.37676,-1.864,-1.98,71,85,0.281,4,4,50,0.248756218905473,"strand",1.5,4.17,0.0007187005893344,4.85678180286436,4.85678176777767,4.85605251831648,5.49640065724654,22,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-1,0,-1,0,4,0,4,2,0.170403587443946,-0.606976744186047,0.195833302981519,-0.317817561807332,-0.518324607329843,0.747368421052632,0.0900641025641026,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","87/150","F:Q:L:V:R:I",1.58037603086922,0.0125175169650379,0.632856943325042,2.49720896252777,1.34977418228528,17.4757677148671,0.686348592676127,0.0171758041796076,1.76508291991092,1.11658950345066,21.1173440246382,0.0190556572462216,"lineage2","dr_mutations_pyrazinamide","SER",0,"ERS457398","ERR551515_ERR551516_ERR551514","lineage2.2.1","uz","Nukus","pnca_p.leu182ser","A","E","LEU","LA182","pnca_complex.pdb"
|
|
"L182S","L2","PZA","L","L182",182,"S",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",15.184,0.38,-2.349,5.37676,-1.864,-1.98,71,85,0.281,4,4,50,0.248756218905473,"strand",1.5,4.17,0.0007187005893344,4.85678180286436,4.85678176777767,4.85605251831648,5.49640065724654,22,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-1,0,-1,0,4,0,4,2,0.170403587443946,-0.606976744186047,0.195833302981519,-0.317817561807332,-0.518324607329843,0.747368421052632,0.0900641025641026,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","87/150","F:Q:L:V:R:I",1.58037603086922,0.0125175169650379,0.632856943325042,2.49720896252777,1.34977418228528,17.4757677148671,0.686348592676127,0.0171758041796076,1.76508291991092,1.11658950345066,21.1173440246382,0.0190556572462216,"lineage2","dr_mutations_pyrazinamide","SER",0,"ERR1023413","ERR1023413","lineage2.2.1","","","pnca_p.leu182ser","A","E","LEU","LA182","pnca_complex.pdb"
|
|
"L182S","L2","PZA","L","L182",182,"S",1,"MDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",15.184,0.38,-2.349,5.37676,-1.864,-1.98,71,85,0.281,4,4,50,0.248756218905473,"strand",1.5,4.17,0.0007187005893344,4.85678180286436,4.85678176777767,4.85605251831648,5.49640065724654,22,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-1,0,-1,0,4,0,4,2,0.170403587443946,-0.606976744186047,0.195833302981519,-0.317817561807332,-0.518324607329843,0.747368421052632,0.0900641025641026,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","87/150","F:Q:L:V:R:I",1.58037603086922,0.0125175169650379,0.632856943325042,2.49720896252777,1.34977418228528,17.4757677148671,0.686348592676127,0.0171758041796076,1.76508291991092,1.11658950345066,21.1173440246382,0.0190556572462216,"lineage2","dr_mutations_pyrazinamide","SER",0,"MDR_19359","SRR6824403","lineage2.2.1","cn","China: Luoding City, Yunfu City, Guangdong Province","pnca_p.leu182ser","A","E","LEU","LA182","pnca_complex.pdb"
|
|
"L182S","L3","PZA","L","L182",182,"S",0,"Pre-XDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",15.184,0.38,-2.349,5.37676,-1.864,-1.98,71,85,0.281,4,4,50,0.248756218905473,"strand",1.5,4.17,0.0007187005893344,4.85678180286436,4.85678176777767,4.85605251831648,5.49640065724654,22,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-1,0,-1,0,4,0,4,2,0.170403587443946,-0.606976744186047,0.195833302981519,-0.317817561807332,-0.518324607329843,0.747368421052632,0.0900641025641026,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","87/150","F:Q:L:V:R:I",1.58037603086922,0.0125175169650379,0.632856943325042,2.49720896252777,1.34977418228528,17.4757677148671,0.686348592676127,0.0171758041796076,1.76508291991092,1.11658950345066,21.1173440246382,0.0190556572462216,"lineage3","dr_mutations_pyrazinamide","SER",0,"ERR2516750","ERR2516750","lineage3","gb","UK","pnca_p.leu182ser","A","E","LEU","LA182","pnca_complex.pdb"
|
|
"L182S","L2","PZA","L","L182",182,"S",1,"MDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",15.184,0.38,-2.349,5.37676,-1.864,-1.98,71,85,0.281,4,4,50,0.248756218905473,"strand",1.5,4.17,0.0007187005893344,4.85678180286436,4.85678176777767,4.85605251831648,5.49640065724654,22,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-1,0,-1,0,4,0,4,2,0.170403587443946,-0.606976744186047,0.195833302981519,-0.317817561807332,-0.518324607329843,0.747368421052632,0.0900641025641026,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","87/150","F:Q:L:V:R:I",1.58037603086922,0.0125175169650379,0.632856943325042,2.49720896252777,1.34977418228528,17.4757677148671,0.686348592676127,0.0171758041796076,1.76508291991092,1.11658950345066,21.1173440246382,0.0190556572462216,"lineage2","dr_mutations_pyrazinamide","SER",0,"ERR1034876","ERR1034876","lineage2.2.1","pt","Portugal","pnca_p.leu182ser","A","E","LEU","LA182","pnca_complex.pdb"
|
|
"L182S","L2","PZA","L","L182",182,"S",1,"Pre-XDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",15.184,0.38,-2.349,5.37676,-1.864,-1.98,71,85,0.281,4,4,50,0.248756218905473,"strand",1.5,4.17,0.0007187005893344,4.85678180286436,4.85678176777767,4.85605251831648,5.49640065724654,22,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-1,0,-1,0,4,0,4,2,0.170403587443946,-0.606976744186047,0.195833302981519,-0.317817561807332,-0.518324607329843,0.747368421052632,0.0900641025641026,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","87/150","F:Q:L:V:R:I",1.58037603086922,0.0125175169650379,0.632856943325042,2.49720896252777,1.34977418228528,17.4757677148671,0.686348592676127,0.0171758041796076,1.76508291991092,1.11658950345066,21.1173440246382,0.0190556572462216,"lineage2","dr_mutations_pyrazinamide","SER",0,"ERR2516183","ERR2516183","lineage2.2.1","be","Belgium","pnca_p.leu182ser","A","E","LEU","LA182","pnca_complex.pdb"
|
|
"L182S","L3","PZA","L","L182",182,"S",0,"Pre-XDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",15.184,0.38,-2.349,5.37676,-1.864,-1.98,71,85,0.281,4,4,50,0.248756218905473,"strand",1.5,4.17,0.0007187005893344,4.85678180286436,4.85678176777767,4.85605251831648,5.49640065724654,22,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-1,0,-1,0,4,0,4,2,0.170403587443946,-0.606976744186047,0.195833302981519,-0.317817561807332,-0.518324607329843,0.747368421052632,0.0900641025641026,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","87/150","F:Q:L:V:R:I",1.58037603086922,0.0125175169650379,0.632856943325042,2.49720896252777,1.34977418228528,17.4757677148671,0.686348592676127,0.0171758041796076,1.76508291991092,1.11658950345066,21.1173440246382,0.0190556572462216,"lineage3","dr_mutations_pyrazinamide","SER",0,"ERR2517023","ERR2517023","lineage3","gb","UK","pnca_p.leu182ser","A","E","LEU","LA182","pnca_complex.pdb"
|
|
"L182S","L3","PZA","L","L182",182,"S",0,"Pre-XDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",15.184,0.38,-2.349,5.37676,-1.864,-1.98,71,85,0.281,4,4,50,0.248756218905473,"strand",1.5,4.17,0.0007187005893344,4.85678180286436,4.85678176777767,4.85605251831648,5.49640065724654,22,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-1,0,-1,0,4,0,4,2,0.170403587443946,-0.606976744186047,0.195833302981519,-0.317817561807332,-0.518324607329843,0.747368421052632,0.0900641025641026,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","87/150","F:Q:L:V:R:I",1.58037603086922,0.0125175169650379,0.632856943325042,2.49720896252777,1.34977418228528,17.4757677148671,0.686348592676127,0.0171758041796076,1.76508291991092,1.11658950345066,21.1173440246382,0.0190556572462216,"lineage3","dr_mutations_pyrazinamide","SER",0,"ERR2516947","ERR2516947","lineage3","gb","UK","pnca_p.leu182ser","A","E","LEU","LA182","pnca_complex.pdb"
|
|
"L182S","L2","PZA","L","L182",182,"S",NA,"MDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",15.184,0.38,-2.349,5.37676,-1.864,-1.98,71,85,0.281,4,4,50,0.248756218905473,"strand",1.5,4.17,0.0007187005893344,4.85678180286436,4.85678176777767,4.85605251831648,5.49640065724654,22,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-1,0,-1,0,4,0,4,2,0.170403587443946,-0.606976744186047,0.195833302981519,-0.317817561807332,-0.518324607329843,0.747368421052632,0.0900641025641026,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","87/150","F:Q:L:V:R:I",1.58037603086922,0.0125175169650379,0.632856943325042,2.49720896252777,1.34977418228528,17.4757677148671,0.686348592676127,0.0171758041796076,1.76508291991092,1.11658950345066,21.1173440246382,0.0190556572462216,"lineage2","dr_mutations_pyrazinamide","SER",0,"SRS797266","SRR1723792","lineage2.2.1","cn","China:Guangdong","pnca_p.leu182ser","A","E","LEU","LA182","pnca_complex.pdb"
|
|
"L182S","L4","PZA","L","L182",182,"S",1,"Pre-XDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",15.184,0.38,-2.349,5.37676,-1.864,-1.98,71,85,0.281,4,4,50,0.248756218905473,"strand",1.5,4.17,0.0007187005893344,4.85678180286436,4.85678176777767,4.85605251831648,5.49640065724654,22,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-1,0,-1,0,4,0,4,2,0.170403587443946,-0.606976744186047,0.195833302981519,-0.317817561807332,-0.518324607329843,0.747368421052632,0.0900641025641026,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","87/150","F:Q:L:V:R:I",1.58037603086922,0.0125175169650379,0.632856943325042,2.49720896252777,1.34977418228528,17.4757677148671,0.686348592676127,0.0171758041796076,1.76508291991092,1.11658950345066,21.1173440246382,0.0190556572462216,"lineage4","dr_mutations_pyrazinamide","SER",0,"ERR2516485","ERR2516485","lineage4.3.4.2;lineage4.1.2.1","pe","Peru","pnca_p.leu182ser","A","E","LEU","LA182","pnca_complex.pdb"
|
|
"L182S","L2","PZA","L","L182",182,"S",1,"Pre-XDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",15.184,0.38,-2.349,5.37676,-1.864,-1.98,71,85,0.281,4,4,50,0.248756218905473,"strand",1.5,4.17,0.0007187005893344,4.85678180286436,4.85678176777767,4.85605251831648,5.49640065724654,22,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-1,0,-1,0,4,0,4,2,0.170403587443946,-0.606976744186047,0.195833302981519,-0.317817561807332,-0.518324607329843,0.747368421052632,0.0900641025641026,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","87/150","F:Q:L:V:R:I",1.58037603086922,0.0125175169650379,0.632856943325042,2.49720896252777,1.34977418228528,17.4757677148671,0.686348592676127,0.0171758041796076,1.76508291991092,1.11658950345066,21.1173440246382,0.0190556572462216,"lineage2","dr_mutations_pyrazinamide","SER",0,"ERS2592779","ERR2677433","lineage2.2.1","de","Germany","pnca_p.leu182ser","A","E","LEU","LA182","pnca_complex.pdb"
|
|
"L182S","L4","PZA","L","L182",182,"S",NA,"Pre-XDR","DM","hydrophobic","hydrophilic","non-polar","neutral","non-polar","polar",15.184,0.38,-2.349,5.37676,-1.864,-1.98,71,85,0.281,4,4,50,0.248756218905473,"strand",1.5,4.17,0.0007187005893344,4.85678180286436,4.85678176777767,4.85605251831648,5.49640065724654,22,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-1,0,-1,0,4,0,4,2,0.170403587443946,-0.606976744186047,0.195833302981519,-0.317817561807332,-0.518324607329843,0.747368421052632,0.0900641025641026,"Stabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","87/150","F:Q:L:V:R:I",1.58037603086922,0.0125175169650379,0.632856943325042,2.49720896252777,1.34977418228528,17.4757677148671,0.686348592676127,0.0171758041796076,1.76508291991092,1.11658950345066,21.1173440246382,0.0190556572462216,"lineage4","dr_mutations_pyrazinamide","SER",0,"ERR2515756","ERR2515756","lineage4.8","za","South Africa","pnca_p.leu182ser","A","E","LEU","LA182","pnca_complex.pdb"
|
|
"L182W","L4","PZA","L","L182",182,"W",NA,"MDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",15.184,-0.228,-1.318,4.86413,-1.198,-1.15,75,85,0.281,4,4,50,0.248756218905473,"strand",1.5,4.17,NA,NA,NA,NA,NA,-20,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-1,0,-1,0,4,0,4,2,-0.0577507598784194,-0.340568475452196,0.177162202521872,-0.204262574595055,-0.301047120418848,0.789473684210526,0.0900641025641026,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","87/150","F:Q:L:V:R:I",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage4","other_mutations_pyrazinamide","TRP",0,"ERR1034735","ERR1034735","lineage4.3.3","pe","Peru","pnca_p.leu182trp","A","E","LEU","LA182","pnca_complex.pdb"
|
|
"L182W","L2","PZA","L","L182",182,"W",NA,"Pre-XDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",15.184,-0.228,-1.318,4.86413,-1.198,-1.15,75,85,0.281,4,4,50,0.248756218905473,"strand",1.5,4.17,NA,NA,NA,NA,NA,-20,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-1,0,-1,0,4,0,4,2,-0.0577507598784194,-0.340568475452196,0.177162202521872,-0.204262574595055,-0.301047120418848,0.789473684210526,0.0900641025641026,"Destabilising","Destabilising","Destabilising","Destabilising","Destabilising","effect",-0.038,0.389,"5:4","87/150","F:Q:L:V:R:I",NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,"lineage2","other_mutations_pyrazinamide","TRP",0,"ERR133861","ERR133861","lineage2.2.1","ru","Russia","pnca_p.leu182trp","A","E","LEU","LA182","pnca_complex.pdb"
|
|
"V183L","L2","PZA","V","V183",183,"L",NA,"Pre-MDR","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",17.921,-0.108,-0.423,-0.102908,-0.776,-0.67,-6,53,0.4,4,4,34,0.195402298850575,"strand",3.5,4.1,0.0001437401178668,1.2119588062211,4.59700131334244e-05,0,1.01056822389159e-25,-10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-3,0,-1,-2,-2,0,0,-4,-0.0273556231003039,-0.109302325581395,-0.0197854341305852,-0.13231031543052,-0.175392670157068,-0.0645161290322581,0.128205128205128,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","neutral",0.083,0.59,"5:3","59/150","L:V:I:R:C:T:A:G",-9.98752126245063,0.942832958100734,139.277183325399,-0.0717096729269459,NA,144471.706314865,0.0834878586628579,1,0,0,25.8386585962163,0.999999999999746,"lineage2","other_mutations_pyrazinamide","LEU",0,"ERR751934","ERR751934","lineage2.2.1","th","Thailand","pnca_p.val183leu","A","E","VAL","VA183","pnca_complex.pdb"
|
|
"V183L","L2","PZA","V","V183",183,"L",0,"Sensitive","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",17.921,-0.108,-0.423,-0.102908,-0.776,-0.67,-6,53,0.4,4,4,34,0.195402298850575,"strand",3.5,4.1,0.0001437401178668,1.2119588062211,4.59700131334244e-05,0,1.01056822389159e-25,-10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-3,0,-1,-2,-2,0,0,-4,-0.0273556231003039,-0.109302325581395,-0.0197854341305852,-0.13231031543052,-0.175392670157068,-0.0645161290322581,0.128205128205128,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","neutral",0.083,0.59,"5:3","59/150","L:V:I:R:C:T:A:G",-9.98752126245063,0.942832958100734,139.277183325399,-0.0717096729269459,NA,144471.706314865,0.0834878586628579,1,0,0,25.8386585962163,0.999999999999746,"lineage2","other_mutations_pyrazinamide","LEU",0,"SAMN03647495,SRR2100322","SRR2100322","lineage2.2.1","","","pnca_p.val183leu","A","E","VAL","VA183","pnca_complex.pdb"
|
|
"V183L","L2","PZA","V","V183",183,"L",0,"Sensitive","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",17.921,-0.108,-0.423,-0.102908,-0.776,-0.67,-6,53,0.4,4,4,34,0.195402298850575,"strand",3.5,4.1,0.0001437401178668,1.2119588062211,4.59700131334244e-05,0,1.01056822389159e-25,-10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-3,0,-1,-2,-2,0,0,-4,-0.0273556231003039,-0.109302325581395,-0.0197854341305852,-0.13231031543052,-0.175392670157068,-0.0645161290322581,0.128205128205128,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","neutral",0.083,0.59,"5:3","59/150","L:V:I:R:C:T:A:G",-9.98752126245063,0.942832958100734,139.277183325399,-0.0717096729269459,NA,144471.706314865,0.0834878586628579,1,0,0,25.8386585962163,0.999999999999746,"lineage2","other_mutations_pyrazinamide","LEU",0,"ERS2286416","ERR2503489","lineage2.2.1","fi","Finland","pnca_p.val183leu","A","E","VAL","VA183","pnca_complex.pdb"
|
|
"V183L","L2","PZA","V","V183",183,"L",NA,"Sensitive","OM","hydrophobic","hydrophobic","non-polar","non-polar","non-polar","non-polar",17.921,-0.108,-0.423,-0.102908,-0.776,-0.67,-6,53,0.4,4,4,34,0.195402298850575,"strand",3.5,4.1,0.0001437401178668,1.2119588062211,4.59700131334244e-05,0,1.01056822389159e-25,-10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-3,0,-1,-2,-2,0,0,-4,-0.0273556231003039,-0.109302325581395,-0.0197854341305852,-0.13231031543052,-0.175392670157068,-0.0645161290322581,0.128205128205128,"Destabilising","Destabilising","Stabilising","Destabilising","Destabilising","neutral",0.083,0.59,"5:3","59/150","L:V:I:R:C:T:A:G",-9.98752126245063,0.942832958100734,139.277183325399,-0.0717096729269459,NA,144471.706314865,0.0834878586628579,1,0,0,25.8386585962163,0.999999999999746,"lineage2","other_mutations_pyrazinamide","LEU",0,"ERR752136","ERR752136","lineage2.2.1","th","Thailand","pnca_p.val183leu","A","E","VAL","VA183","pnca_complex.pdb"
|