310 KiB
310 KiB
| 1 | mutationinformation | wild_type | position | mutant_type | chain | ligand_id | ligand_distance | duet_stability_change | duet_outcome | ligand_affinity_change | ligand_outcome | duet_scaled | affinity_scaled | wild_pos | wild_chain_pos | ddg_foldx | contacts | electro_rr | electro_mm | electro_sm | electro_ss | disulfide_rr | disulfide_mm | disulfide_sm | disulfide_ss | hbonds_rr | hbonds_mm | hbonds_sm | hbonds_ss | partcov_rr | partcov_mm | partcov_sm | partcov_ss | vdwclashes_rr | vdwclashes_mm | vdwclashes_sm | vdwclashes_ss | volumetric_rr | volumetric_mm | volumetric_sm | volumetric_ss | foldx_scaled | foldx_outcome | deepddg | deepddg_outcome | deepddg_scaled | asa | rsa | ss | ss_class | kd_values | rd_values | wt_3upper | consurf_score | consurf_scaled | consurf_colour | consurf_colour_rev | consurf_ci_upper | consurf_ci_lower | consurf_ci_colour | consurf_msa_data | consurf_aa_variety | snap2_score | snap2_scaled | snap2_accuracy_pc | snap2_outcome | mutation | af | beta_logistic | or_logistic | pval_logistic | se_logistic | zval_logistic | ci_low_logistic | ci_hi_logistic | or_mychisq | log10_or_mychisq | or_fisher | pval_fisher | neglog_pval_fisher | ci_low_fisher | ci_hi_fisher | est_chisq | pval_chisq | ddg_dynamut2 | ddg_dynamut2_scaled | ddg_dynamut2_outcome | mut_3upper | seq_offset4pdb | pdb_file |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 2 | M1T | M | 1 | T | A | PZA | 23.978 | 0.109 | Stabilising | 0.344 | Stabilising | 0.0926870748299319 | 0.1542600896860986 | M1 | MA1 | 0.867771 | 10.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.0 | 0.0 | 0.0 | 2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.031606108727481985 | Destabilising | -1.096 | Destabilising | -0.18687127024722933 | 88 | 0.3928571428571428 | - | loop | 0.6333333333333333 | 4.12 | MET | -1.048 | -0.8632619439868204 | 9 | 9 | -1.178 | -0.993 | 9:9 | 21/150 | V:M | 52 | 0.5473684210526316 | 75 | effect | pnca_p.met1thr | 0.0007187005893344 | 14.1489809714062 | 1395803.74890195 | 0.890414731995374 | 102.692976014008 | 0.137779442378573 | 507.712885368923 | 97.3828619670747 | 1.98848253379833 | inf | 2.1018584548314e-08 | 7.67739653395739 | 10.9022485555592 | inf | 42.8452490786805 | 5.924579267292849e-11 | 0.51 | 0.2865168539325842 | Stabilising | THR | 0 | pnca_complex.pdb | |
| 3 | M1R | M | 1 | R | A | PZA | 23.978 | 0.6940000000000001 | Stabilising | -0.16 | Destabilising | 0.5901360544217688 | -0.0405268490374873 | M1 | MA1 | -0.00977971 | -14.0 | 0.0 | 0.0 | 0.0 | -20.0 | 0.0 | 0.0 | 0.0 | 0.0 | -2.0 | 0.0 | -2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 1.0 | 0.0 | -1.0 | 1.0 | 0.0 | 0.0 | -2.0 | -2.0 | -0.0018802795508728756 | Stabilising | -0.78 | Destabilising | -0.1329923273657289 | 88 | 0.3928571428571428 | - | loop | 0.6333333333333333 | 4.12 | MET | -1.048 | -0.8632619439868204 | 9 | 9 | -1.178 | -0.993 | 9:9 | 21/150 | V:M | 44 | 0.4631578947368421 | 71 | effect | 1.21 | 0.6797752808988764 | Stabilising | ARG | 0 | pnca_complex.pdb | ||||||||||||||||||
| 4 | M1I | M | 1 | I | A | PZA | 23.978 | -0.347 | Destabilising | -0.294 | Destabilising | -0.0896640826873385 | -0.0744680851063829 | M1 | MA1 | -0.0549615 | 6.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -3.0 | 0.0 | -3.0 | -3.0 | 0.0 | 0.0 | 0.0 | 0.0 | -0.010567080673690688 | Stabilising | -0.407 | Destabilising | -0.06939471440750213 | 88 | 0.3928571428571428 | - | loop | 0.6333333333333333 | 4.12 | MET | -1.048 | -0.8632619439868204 | 9 | 9 | -1.178 | -0.993 | 9:9 | 21/150 | V:M | 7 | 0.07368421052631578 | 53 | effect | pnca_p.met1ile | 0.0001437401178668 | -9.98752126245056 | 4.59700131334276e-05 | 0.942832958100734 | 139.277183325397 | -0.0717096729269464 | 144471.706314837 | 1.2119588062211 | 0.0834878586628579 | 0.0 | 1.0 | 0.0 | 0.0 | 25.8386585962163 | 1.0105682238915901e-25 | 0.999999999999746 | -0.79 | -0.2068062827225131 | Destabilising | ILE | 0 | pnca_complex.pdb | |
| 5 | M1K | M | 1 | K | A | PZA | 23.978 | 0.296 | Stabilising | 0.215 | Stabilising | 0.2517006802721089 | 0.0964125560538116 | M1 | MA1 | 0.0794895 | -6.0 | -2.0 | 0.0 | 0.0 | -18.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -2.0 | 0.0 | 0.0 | 0.0 | 0.0 | -1.0 | 0.0 | -1.0 | -1.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.002895180617574429 | Destabilising | -1.017 | Destabilising | -0.1734015345268542 | 88 | 0.3928571428571428 | - | loop | 0.6333333333333333 | 4.12 | MET | -1.048 | -0.8632619439868204 | 9 | 9 | -1.178 | -0.993 | 9:9 | 21/150 | V:M | 70 | 0.7368421052631579 | 85 | effect | pnca_p.met1lys | 7.18700589334483e-05 | -8.98740878149642 | 0.0001249735077034 | 0.940032862253633 | 119.468044435492 | -0.0752285585987748 | 4692673.51081395 | 2.42412778478352 | 0.384555509373631 | 0.0 | 1.0 | 0.0 | 0.0 | 188.544222231268 | 1.0341007080334399e-29 | 0.999999999999997 | -0.34 | -0.0890052356020942 | Destabilising | LYS | 0 | pnca_complex.pdb | |
| 6 | R2W | R | 2 | W | A | PZA | 21.092 | -0.1639999999999999 | Destabilising | -1.147 | Destabilising | -0.0423772609819121 | -0.2905268490374873 | R2 | RA2 | 4.38565 | 8.0 | 30.0 | 0.0 | 4.0 | 26.0 | 0.0 | 0.0 | 0.0 | 0.0 | 4.0 | 0.0 | 2.0 | 2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -5.0 | 5.0 | 6.0 | 0.0 | 6.0 | 4.0 | 0.15973491939772289 | Destabilising | -0.74 | Destabilising | -0.12617220801364024 | 55 | 0.2007299270072992 | E | strand | -0.2666666666666666 | 4.74 | ARG | -0.015 | -0.012355848434925865 | 5 | 5 | -0.244 | 0.083 | 6:5 | 84/150 | R:K:N:H:T:S:E | 58 | 0.6105263157894737 | 75 | effect | -0.16 | -0.0418848167539267 | Destabilising | TRP | 0 | pnca_complex.pdb | ||||||||||||||||||
| 7 | R2P | R | 2 | P | A | PZA | 21.092 | -1.031 | Destabilising | -2.244 | Destabilising | -0.2664082687338501 | -0.56838905775076 | R2 | RA2 | 4.20376 | 48.0 | 28.0 | 0.0 | 4.0 | 24.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.0 | 0.0 | 4.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 4.0 | 2.0 | 1.0 | 1.0 | 4.0 | 0.0 | 6.0 | 0.0 | 0.1531100896713991 | Destabilising | -1.935 | Destabilising | -0.329923273657289 | 55 | 0.2007299270072992 | E | strand | -0.2666666666666666 | 4.74 | ARG | -0.015 | -0.012355848434925865 | 5 | 5 | -0.244 | 0.083 | 6:5 | 84/150 | R:K:N:H:T:S:E | 63 | 0.6631578947368421 | 80 | effect | -0.43 | -0.112565445026178 | Destabilising | PRO | 0 | pnca_complex.pdb | ||||||||||||||||||
| 8 | R2L | R | 2 | L | A | PZA | 21.092 | 0.062 | Stabilising | -2.083 | Destabilising | 0.0527210884353741 | -0.5276089159067883 | R2 | RA2 | 1.78755 | 38.0 | 30.0 | 0.0 | 4.0 | 26.0 | 0.0 | 0.0 | 0.0 | 0.0 | 4.0 | 0.0 | 2.0 | 2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 1.0 | 0.0 | -2.0 | 2.0 | 0.0 | 0.0 | 0.0 | -2.0 | 0.06510646202259632 | Destabilising | -0.708 | Destabilising | -0.1207161125319693 | 55 | 0.2007299270072992 | E | strand | -0.2666666666666666 | 4.74 | ARG | -0.015 | -0.012355848434925865 | 5 | 5 | -0.244 | 0.083 | 6:5 | 84/150 | R:K:N:H:T:S:E | 44 | 0.4631578947368421 | 71 | effect | pnca_p.arg2leu | 7.18700589334483e-05 | -8.9874087814964 | 0.0001249735077034 | 0.940032862253633 | 119.46804443549 | -0.0752285585987755 | 4692673.51081259 | 2.42412778478352 | 0.384555509373631 | 0.0 | 1.0 | 0.0 | 0.0 | 188.544222231268 | 1.0341007080334399e-29 | 0.999999999999997 | -0.24 | -0.06282722513089 | Destabilising | LEU | 0 | pnca_complex.pdb | |
| 9 | A3E | A | 3 | E | A | PZA | 18.028 | -2.829 | Destabilising | -1.5519999999999998 | Destabilising | -0.7310077519379844 | -0.3931104356636271 | A3 | AA3 | 2.75936 | -30.0 | -38.0 | 0.0 | -2.0 | -36.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -13.0 | 0.0 | -3.0 | -14.0 | -4.0 | 0.0 | -2.0 | -9.0 | 0.1005018975954079 | Destabilising | -5.34 | Destabilising | -0.9104859335038362 | 0 | 0.0 | E | strand | 0.3666666666666666 | 8.38 | ALA | -0.873 | -0.7191103789126854 | 8 | 8 | -0.993 | -0.827 | 9:8 | 141/150 | A:G:T:V:C | 56 | 0.5894736842105263 | 75 | effect | pnca_p.ala3glu | 0.0002874802357337 | 14.1464514590954 | 1392277.50785087 | 0.930573112990226 | 162.371849599086 | 0.0871237932808215 | 0.011399544335555 | 38.8547368421053 | 1.58944397188817 | inf | 0.0008528275207519 | 3.06913879340442 | 3.20302487654751 | inf | 13.9909822352959 | 0.0001836895199759 | -1.11 | -0.2905759162303665 | Destabilising | GLU | 0 | pnca_complex.pdb | |
| 10 | A3P | A | 3 | P | A | PZA | 18.028 | -1.124 | Destabilising | -2.664 | Destabilising | -0.2904392764857881 | -0.6747720364741641 | A3 | AA3 | -0.155697 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -7.0 | 2.0 | -7.0 | -4.0 | -2.0 | 0.0 | -2.0 | -1.0 | -0.029934822733215412 | Stabilising | -3.837 | Destabilising | -0.6542199488491048 | 0 | 0.0 | E | strand | 0.3666666666666666 | 8.38 | ALA | -0.873 | -0.7191103789126854 | 8 | 8 | -0.993 | -0.827 | 9:8 | 141/150 | A:G:T:V:C | 66 | 0.6947368421052632 | 80 | effect | pnca_p.ala3pro | 7.18700589334483e-05 | 12.1451538387263 | 188179.926264599 | 0.919026337424228 | 119.468044436222 | 0.101660271548263 | 5.01153666063644e-06 | 9.70142977291842 | 0.986835744238421 | inf | 0.170978870202674 | 0.767057556984365 | 0.124324963210678 | inf | 0.763784339928386 | 0.382146811758261 | -0.13 | -0.0340314136125654 | Destabilising | PRO | 0 | pnca_complex.pdb | |
| 11 | L4S | L | 4 | S | A | PZA | 15.328 | -3.87 | Destabilising | -1.078 | Destabilising | -1.0 | -0.2730496453900709 | L4 | LA4 | 5.57838 | 22.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -3.0 | 0.0 | -1.0 | -2.0 | 6.0 | 0.0 | 4.0 | 6.0 | 0.20317674225482413 | Destabilising | -2.638 | Destabilising | -0.4497868712702472 | 0 | 0.0 | E | strand | 3.3666666666666667 | 8.8 | LEU | -1.075 | -0.8855024711696869 | 9 | 9 | -1.152 | -1.028 | 9:9 | 146/150 | F:V:L:I | 63 | 0.6631578947368421 | 80 | effect | pnca_p.leu4ser | 0.0024435820037372 | 3.34839479820379 | 28.4570177059942 | 4.89069202996555e-12 | 0.484662577645081 | 6.90871330415739 | 12.0071584873314 | 83.7151686983107 | 28.4570212765957 | 1.4541894385859 | 28.4308865607855 | 5.6263316435115e-18 | 17.2497746719749 | 10.8739157094292 | 94.2522723934353 | 107.057952768928 | 4.32340113554558e-25 | -3.7 | -0.968586387434555 | Destabilising | SER | 0 | pnca_complex.pdb |
| 12 | L4W | L | 4 | W | A | PZA | 15.328 | -2.169 | Destabilising | -2.216 | Destabilising | -0.5604651162790698 | -0.5612968591691996 | L4 | LA4 | 1.63111 | -46.0 | 6.0 | 0.0 | 0.0 | 6.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -15.0 | 0.0 | -7.0 | -8.0 | 0.0 | 0.0 | -16.0 | 2.0 | 0.05940857669417755 | Destabilising | -2.168 | Destabilising | -0.36965046888320546 | 0 | 0.0 | E | strand | 3.3666666666666667 | 8.8 | LEU | -1.075 | -0.8855024711696869 | 9 | 9 | -1.152 | -1.028 | 9:9 | 146/150 | F:V:L:I | 70 | 0.7368421052631579 | 85 | effect | pnca_p.leu4trp | 0.0012217910018686 | 3.12479275069714 | 22.7551786098964 | 9.15103299018708e-07 | 0.636534850451638 | 4.90906782005734 | 7.42096527532349 | 98.7712876576624 | 22.7551797040169 | 1.35708026960092 | 22.7463684762183 | 7.157958206418241e-09 | 8.14521084167875 | 6.3414443600848 | 123.179124931302 | 46.6274188614457 | 8.58505795592483e-12 | -1.93 | -0.5052356020942408 | Destabilising | TRP | 0 | pnca_complex.pdb |
| 13 | L4V | L | 4 | V | A | PZA | 15.328 | -1.717 | Destabilising | -2.8280000000000003 | Destabilising | -0.4436692506459948 | -0.7163120567375887 | L4 | LA4 | 1.19624 | 22.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -3.0 | 0.0 | -1.0 | -2.0 | 2.0 | 0.0 | 0.0 | 0.0 | 0.043569664697440974 | Destabilising | -1.68 | Destabilising | -0.2864450127877238 | 0 | 0.0 | E | strand | 3.3666666666666667 | 8.8 | LEU | -1.075 | -0.8855024711696869 | 9 | 9 | -1.152 | -1.028 | 9:9 | 146/150 | F:V:L:I | 22 | 0.23157894736842105 | 63 | effect | -1.95 | -0.5104712041884817 | Destabilising | VAL | 0 | pnca_complex.pdb | ||||||||||||||||||
| 14 | I5T | I | 5 | T | A | PZA | 11.437 | -3.43 | Destabilising | -0.945 | Destabilising | -0.8863049095607235 | -0.2393617021276595 | I5 | IA5 | 3.67776 | 32.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -4.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 4.0 | 0.0 | 2.0 | 2.0 | 0.0 | 0.0 | 4.0 | 0.0 | 0.1339520247088047 | Destabilising | -2.709 | Destabilising | -0.4618925831202046 | 0 | 0.0 | E | strand | 4.266666666666667 | 12.6 | ILE | -0.011 | -0.009060955518945634 | 5 | 5 | -0.244 | 0.083 | 6:5 | 146/150 | G:F:I:L:V | 63 | 0.6631578947368421 | 80 | effect | pnca_p.ile5thr | 0.0002874802357337 | 2.67848962960141 | 14.5630810302278 | 0.0202679102821362 | 1.15384949648317 | 2.3213509541454 | 1.86363317860697 | 294.488177946116 | 14.5631313131313 | 1.16325476548539 | 14.5631012253236 | 0.0174140488202037 | 1.75910024233227 | 1.16837785201846 | 760.989759542733 | 5.81873994206135 | 0.0158563003544608 | -3.3 | -0.8638743455497382 | Destabilising | THR | 0 | pnca_complex.pdb |
| 15 | I5S | I | 5 | S | A | PZA | 11.437 | -3.843 | Destabilising | -0.778 | Destabilising | -0.9930232558139536 | -0.1970618034447821 | I5 | IA5 | 5.83176 | 30.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -4.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 4.0 | 0.0 | 2.0 | 2.0 | 0.0 | 0.0 | 4.0 | 0.0 | 0.21240539339593092 | Destabilising | -3.518 | Destabilising | -0.5998294970161977 | 0 | 0.0 | E | strand | 4.266666666666667 | 12.6 | ILE | -0.011 | -0.009060955518945634 | 5 | 5 | -0.244 | 0.083 | 6:5 | 146/150 | G:F:I:L:V | 63 | 0.6631578947368421 | 80 | effect | pnca_p.ile5ser | 7.18700589334483e-05 | 12.1451538387253 | 188179.92626441 | 0.919026337424193 | 119.46804443616 | 0.101660271548307 | 5.0115366606943e-06 | 9.70142977291842 | 0.986835744238421 | inf | 0.170978870202674 | 0.767057556984365 | 0.124324963210678 | inf | 0.763784339928386 | 0.382146811758261 | -3.58 | -0.93717277486911 | Destabilising | SER | 0 | pnca_complex.pdb | |
| 16 | I6L | I | 6 | L | A | PZA | 9.258 | -0.5479999999999999 | Destabilising | -3.018 | Destabilising | -0.1416020671834625 | -0.7644376899696049 | I6 | IA6 | 0.267883 | -6.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -7.0 | 0.0 | -2.0 | -5.0 | 2.0 | 0.0 | -2.0 | -2.0 | 0.009756881970294073 | Destabilising | -1.616 | Destabilising | -0.27553282182438193 | 1 | 0.0050761421319796 | E | strand | 4.4 | 11.36 | ILE | -0.6 | -0.4942339373970346 | 7 | 7 | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | 5 | 0.05263157894736842 | 53 | effect | pnca_p.ile6leu | 0.0097024579560155 | -0.953704270146009 | 0.385311080310026 | 0.0037560422096937 | 0.329095586242593 | -2.89795521427317 | 0.189089468462042 | 0.697385389891155 | 0.385310257492613 | -0.414189429312607 | 0.385326683377145 | 0.0017355697972772 | 2.76055791615401 | 0.180049643960023 | 0.733980750878148 | 8.35414540919546 | 0.0038480840706912 | -0.58 | -0.1518324607329843 | Destabilising | LEU | 0 | pnca_complex.pdb |
| 17 | I6V | I | 6 | V | A | PZA | 9.258 | -1.528 | Destabilising | -2.761 | Destabilising | -0.3948320413436692 | -0.6993414387031409 | I6 | IA6 | 1.3314700000000002 | 24.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -1.0 | 0.0 | -1.0 | 0.0 | 2.0 | 0.0 | 2.0 | 0.0 | 0.04849503565731103 | Destabilising | -1.511 | Destabilising | -0.25763000852514917 | 1 | 0.0050761421319796 | E | strand | 4.4 | 11.36 | ILE | -0.6 | -0.4942339373970346 | 7 | 7 | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | -86 | -0.9247311827956989 | 93 | neutral | -1.35 | -0.3534031413612565 | Destabilising | VAL | 0 | pnca_complex.pdb | ||||||||||||||||||
| 18 | I6T | I | 6 | T | A | PZA | 9.258 | -3.089 | Destabilising | -1.244 | Destabilising | -0.7981912144702842 | -0.315096251266464 | I6 | IA6 | 3.71452 | 24.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -1.0 | 0.0 | -1.0 | 0.0 | 2.0 | 0.0 | 0.0 | 0.0 | 0.1352909039255822 | Destabilising | -3.589 | Destabilising | -0.6119352088661552 | 1 | 0.0050761421319796 | E | strand | 4.4 | 11.36 | ILE | -0.6 | -0.4942339373970346 | 7 | 7 | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | 62 | 0.6526315789473685 | 80 | effect | pnca_p.ile6thr | 0.000646830530401 | 14.148558941436 | 1395214.80217275 | 0.896008552350165 | 108.247901039825 | 0.130705157379733 | 226.474535586036 | 87.6075949367089 | 1.94254175795031 | inf | 1.23317897951184e-07 | 6.90897388676731 | 9.59561062779463 | inf | 38.0099632572142 | 7.038428913028e-10 | -3.14 | -0.8219895287958116 | Destabilising | THR | 0 | pnca_complex.pdb | |
| 19 | I6S | I | 6 | S | A | PZA | 9.258 | -3.585 | Destabilising | -1.047 | Destabilising | -0.9263565891472868 | -0.2651975683890577 | I6 | IA6 | 6.01751 | 24.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -1.0 | 0.0 | -1.0 | 0.0 | 2.0 | 0.0 | 4.0 | 0.0 | 0.21917081272445166 | Destabilising | -4.149 | Destabilising | -0.7074168797953964 | 1 | 0.0050761421319796 | E | strand | 4.4 | 11.36 | ILE | -0.6 | -0.4942339373970346 | 7 | 7 | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | 64 | 0.6736842105263158 | 80 | effect | pnca_p.ile6ser | 0.0001437401178668 | 13.1456002256205 | 511754.463552573 | 0.924803768446996 | 139.277183326562 | 0.094384449136928 | 0.0001628371344453 | 19.411022297013 | 1.28804840845689 | inf | 0.0292235860951597 | 1.53426649183163 | 0.91081598550184 | inf | 4.73122070382274 | 0.0296198560706035 | -3.42 | -0.8952879581151832 | Destabilising | SER | 0 | pnca_complex.pdb | |
| 20 | I6M | I | 6 | M | A | PZA | 9.258 | -1.021 | Destabilising | -3.085 | Destabilising | -0.2638242894056847 | -0.7814083080040527 | I6 | IA6 | 0.24349 | -32.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -3.0 | 0.0 | 0.0 | -3.0 | -2.0 | 0.0 | -4.0 | -2.0 | 0.00886843581319794 | Destabilising | -2.364 | Destabilising | -0.4030690537084399 | 1 | 0.0050761421319796 | E | strand | 4.4 | 11.36 | ILE | -0.6 | -0.4942339373970346 | 7 | 7 | -0.728 | -0.553 | 8:7 | 146/150 | M:A:I:L:V | 10 | 0.10526315789473684 | 59 | effect | 0.14 | 0.0786516853932584 | Stabilising | MET | 0 | pnca_complex.pdb | ||||||||||||||||||
| 21 | V7G | V | 7 | G | A | PZA | 5.336 | -3.114 | Destabilising | -1.062 | Destabilising | -0.8046511627906976 | -0.2689969604863222 | V7 | VA7 | 5.26226 | 12.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 3.0 | 0.0 | 1.0 | 2.0 | 8.0 | 0.0 | 11.0 | 21.0 | 0.1916629637453653 | Destabilising | -4.33 | Destabilising | -0.7382779198635976 | 0 | 0.0 | E | strand | 1.7333333333333334 | 11.02 | VAL | -0.66 | -0.5436573311367381 | 7 | 7 | -0.779 | -0.615 | 8:7 | 146/150 | V:I:A | 86 | 0.9052631578947369 | 91 | effect | pnca_p.val7gly | 0.001293661060802 | 3.6647220332212 | 39.0452813634446 | 1.03849290922087e-06 | 0.750321763717271 | 4.88420063289289 | 11.103639297077 | 247.090478887866 | 39.0452814219213 | 1.59156855738766 | 39.0430804499264 | 5.5226464423210094e-11 | 10.2578527592503 | 9.16748833639401 | 349.97982252054 | 60.5607562088978 | 7.134219647799371e-15 | -2.58 | -0.6753926701570682 | Destabilising | GLY | 0 | pnca_complex.pdb |
| 22 | V7L | V | 7 | L | A | PZA | 5.336 | -1.137 | Destabilising | -0.589 | Destabilising | -0.2937984496124031 | -0.1491894630192502 | V7 | VA7 | -0.847275 | -26.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -3.0 | 0.0 | 1.0 | -4.0 | -2.0 | 0.0 | -2.0 | 2.0 | -0.16289990771360455 | Stabilising | -2.289 | Destabilising | -0.3902813299232737 | 0 | 0.0 | E | strand | 1.7333333333333334 | 11.02 | VAL | -0.66 | -0.5436573311367381 | 7 | 7 | -0.779 | -0.615 | 8:7 | 146/150 | V:I:A | 83 | 0.8736842105263158 | 91 | effect | pnca_p.val7leu | 0.0009343107661348 | 2.39307722351576 | 10.9471289278841 | 6.83262964849249e-05 | 0.600967660910521 | 3.98203993188257 | 3.56185012264106 | 40.4315613280321 | 10.9471518987342 | 1.03930114423982 | 10.9440461901209 | 4.53835196843674e-05 | 4.34310182576657 | 3.05117591386949 | 48.6969925271007 | 21.4040928993518 | 3.71976276752962e-06 | -0.99 | -0.2591623036649215 | Destabilising | LEU | 0 | pnca_complex.pdb |
| 23 | V7A | V | 7 | A | A | PZA | 5.336 | -2.592 | Destabilising | -0.97 | Destabilising | -0.6697674418604651 | -0.2456940222897669 | V7 | VA7 | 3.42668 | 2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 5.0 | 0.0 | 3.0 | 2.0 | 4.0 | 0.0 | 6.0 | 3.0 | 0.12480714457418834 | Destabilising | -3.043 | Destabilising | -0.518840579710145 | 0 | 0.0 | E | strand | 1.7333333333333334 | 11.02 | VAL | -0.66 | -0.5436573311367381 | 7 | 7 | -0.779 | -0.615 | 8:7 | 146/150 | V:I:A | 64 | 0.6736842105263158 | 80 | effect | pnca_p.val7ala | 7.18700589334483e-05 | -8.98740878149641 | 0.0001249735077034 | 0.940032862253633 | 119.468044435491 | -0.075228558598775 | 4692673.51081185 | 2.42412778478352 | 0.384555509373631 | 0.0 | 1.0 | 0.0 | 0.0 | 188.544222231268 | 1.0341007080334399e-29 | 0.999999999999997 | -1.9 | -0.4973821989528796 | Destabilising | ALA | 0 | pnca_complex.pdb | |
| 24 | V7F | V | 7 | F | A | PZA | 5.336 | -1.877 | Destabilising | 0.042 | Stabilising | -0.4850129198966407 | 0.0188340807174887 | V7 | VA7 | 4.86315 | -54.0 | -2.0 | 0.0 | 0.0 | -2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -3.0 | 0.0 | 1.0 | -4.0 | -8.0 | 0.0 | -6.0 | -4.0 | 0.17712650878867126 | Destabilising | -2.949 | Destabilising | -0.5028132992327365 | 0 | 0.0 | E | strand | 1.7333333333333334 | 11.02 | VAL | -0.66 | -0.5436573311367381 | 7 | 7 | -0.779 | -0.615 | 8:7 | 146/150 | V:I:A | 83 | 0.8736842105263158 | 91 | effect | pnca_p.val7phe | 0.0002156101768003 | 2.27260607808817 | 9.70465898653049 | 0.06344559022609 | 1.22442760158496 | 1.8560559033024 | 0.929172866365903 | 208.881603004777 | 9.70466975178797 | 0.986980761010679 | 9.70194990589383 | 0.0776844925942494 | 1.10966566656461 | 0.504888890842109 | 570.372842410328 | 2.29168245016684 | 0.130068862702538 | -1.55 | -0.4057591623036649 | Destabilising | PHE | 0 | pnca_complex.pdb |
| 25 | V7I | V | 7 | I | A | PZA | 5.336 | -0.898 | Destabilising | -0.635 | Destabilising | -0.2320413436692506 | -0.1608409321175278 | V7 | VA7 | -1.10338 | -24.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -4.0 | 0.0 | 2.0 | -7.0 | 0.0 | 0.0 | 2.0 | -2.0 | -0.21213950626778436 | Stabilising | -0.738 | Destabilising | -0.1258312020460358 | 0 | 0.0 | E | strand | 1.7333333333333334 | 11.02 | VAL | -0.66 | -0.5436573311367381 | 7 | 7 | -0.779 | -0.615 | 8:7 | 146/150 | V:I:A | 46 | 0.4842105263157895 | 71 | effect | -0.73 | -0.1910994764397905 | Destabilising | ILE | 0 | pnca_complex.pdb | ||||||||||||||||||
| 26 | D8E | D | 8 | E | A | PZA | 3.22 | -0.7859999999999999 | Destabilising | 0.012 | Stabilising | -0.2031007751937984 | 0.0053811659192825 | D8 | DA8 | 1.90122 | -24.0 | -28.0 | 0.0 | 0.0 | -28.0 | 0.0 | 0.0 | 0.0 | 0.0 | -2.0 | 0.0 | -2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.0 | 0.0 | 2.0 | -1.0 | -8.0 | 0.0 | -10.0 | -6.0 | 0.0692465708520604 | Destabilising | -1.417 | Destabilising | -0.24160272804774083 | 5 | 0.0259067357512953 | - | loop | 1.6333333333333335 | 9.48 | ASP | -1.187 | -0.9777594728171335 | 9 | 9 | -1.221 | -1.178 | 9:9 | 146/150 | D:H | 90 | 0.9473684210526315 | 95 | effect | pnca_p.asp8glu | 0.0002874802357337 | 2.67848962960141 | 14.5630810302278 | 0.0202679102821361 | 1.15384949648317 | 2.3213509541454 | 1.86363317860697 | 294.488177945815 | 14.5631313131313 | 1.16325476548539 | 14.5631012253236 | 0.0174140488202037 | 1.75910024233227 | 1.16837785201846 | 760.989759542733 | 5.81873994206135 | 0.0158563003544608 | -0.4 | -0.1047120418848167 | Destabilising | GLU | 0 | pnca_complex.pdb |
| 27 | D8A | D | 8 | A | A | PZA | 3.22 | -0.511 | Destabilising | -3.268 | Destabilising | -0.1320413436692506 | -0.8277608915906789 | D8 | DA8 | 0.541028 | 26.0 | 36.0 | 0.0 | 0.0 | 36.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 4.0 | 0.0 | 0.0 | 0.0 | 0.0 | -5.0 | 0.0 | -4.0 | -1.0 | 0.0 | 0.0 | 6.0 | 1.0 | 0.01970541743456756 | Destabilising | -1.125 | Destabilising | -0.1918158567774936 | 5 | 0.0259067357512953 | - | loop | 1.6333333333333335 | 9.48 | ASP | -1.187 | -0.9777594728171335 | 9 | 9 | -1.221 | -1.178 | 9:9 | 146/150 | D:H | 87 | 0.9157894736842105 | 91 | effect | pnca_p.asp8ala | 0.0001437401178668 | 13.1456002256206 | 511754.463552623 | 0.924803768447001 | 139.277183326572 | 0.094384449136922 | 0.0001628371344451 | 19.411022297013 | 1.28804840845689 | inf | 0.0292235860951597 | 1.53426649183163 | 0.91081598550184 | inf | 4.73122070382274 | 0.0296198560706035 | 0.4 | 0.2247191011235955 | Stabilising | ALA | 0 | pnca_complex.pdb | |
| 28 | D8N | D | 8 | N | A | PZA | 3.22 | -1.182 | Destabilising | -1.655 | Destabilising | -0.3054263565891472 | -0.4191995947315096 | D8 | DA8 | -1.26057 | 0.0 | 34.0 | 0.0 | 0.0 | 34.0 | 0.0 | 0.0 | 0.0 | 0.0 | -4.0 | 0.0 | -2.0 | -2.0 | 0.0 | 0.0 | 0.0 | 0.0 | -7.0 | 0.0 | -5.0 | -4.0 | 0.0 | 0.0 | -4.0 | 2.0 | -0.24236137814350533 | Stabilising | -1.022 | Destabilising | -0.1742540494458653 | 5 | 0.0259067357512953 | - | loop | 1.6333333333333335 | 9.48 | ASP | -1.187 | -0.9777594728171335 | 9 | 9 | -1.221 | -1.178 | 9:9 | 146/150 | D:H | 92 | 0.968421052631579 | 95 | effect | pnca_p.asp8asn | 0.0005030904125341 | 3.37290329402598 | 29.1630732435187 | 0.001789077082818 | 1.07995768762031 | 3.12318096596746 | 4.97876379054103 | 550.894323519252 | 29.1630847029077 | 1.46483345924118 | 29.1293325978315 | 0.0001485295621003 | 3.828187099348 | 3.53443753556636 | 1331.56873199938 | 18.6717493808583 | 1.55265977742841e-05 | -1.29 | -0.3376963350785341 | Destabilising | ASN | 0 | pnca_complex.pdb |
| 29 | D8G | D | 8 | G | A | PZA | 3.22 | -0.851 | Destabilising | -3.445 | Destabilising | -0.2198966408268733 | -0.8725937183383992 | D8 | DA8 | 1.89305 | 34.0 | 38.0 | 0.0 | 0.0 | 38.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -8.0 | -1.0 | -3.0 | -5.0 | 6.0 | 0.0 | 9.0 | 17.0 | 0.0689490016681357 | Destabilising | -1.078 | Destabilising | -0.18380221653878942 | 5 | 0.0259067357512953 | - | loop | 1.6333333333333335 | 9.48 | ASP | -1.187 | -0.9777594728171335 | 9 | 9 | -1.221 | -1.178 | 9:9 | 146/150 | D:H | 92 | 0.968421052631579 | 95 | effect | pnca_p.asp8gly | 0.0007905706482679 | 3.88541626053988 | 48.6872048041474 | 0.0002118075877291 | 1.0488367141091 | 3.70450062271154 | 9.3197738725557 | 893.78337229237 | 48.6872097931617 | 1.68741488635211 | 48.6746878162623 | 1.95392414212297e-07 | 6.70909230105579 | 6.91781679568266 | 2088.84994220519 | 37.2619168572472 | 1.03281930722422e-09 | -0.82 | -0.2146596858638743 | Destabilising | GLY | 0 | pnca_complex.pdb |
| 30 | V9G | V | 9 | G | A | PZA | 6.555 | -3.236 | Destabilising | -1.063 | Destabilising | -0.8361757105943153 | -0.2692502532928065 | V9 | VA9 | 3.70952 | 8.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.0 | -2.0 | 4.0 | 0.0 | 3.0 | 21.0 | 0.13510879304190734 | Destabilising | -3.636 | Destabilising | -0.6199488491048594 | 0 | 0.0 | - | loop | -0.9333333333333332 | 9.57 | VAL | -0.711 | -0.585667215815486 | 8 | 8 | -0.827 | -0.615 | 8:7 | 146/150 | I:C:L:V:M | 83 | 0.8736842105263158 | 91 | effect | pnca_p.val9gly | 0.0003593502946672 | 2.96659528728018 | 19.4256680571767 | 0.0079500503166053 | 1.11770528264822 | 2.65418382943607 | 2.87215213651501 | 380.097158975938 | 19.4256842105263 | 1.28837632444196 | 19.4169790983636 | 0.0036816889015929 | 2.43395291165754 | 1.92061868691892 | 951.403114304703 | 9.87561363723508 | 0.0016748373055023 | -3.48 | -0.9109947643979058 | Destabilising | GLY | 0 | pnca_complex.pdb |
| 31 | V9A | V | 9 | A | A | PZA | 6.555 | -2.467 | Destabilising | -1.286 | Destabilising | -0.6374677002583979 | -0.3257345491388044 | V9 | VA9 | 2.03689 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.0 | 0.0 | 0.0 | 2.0 | 6.0 | 0.0 | 6.0 | 5.0 | 0.07418796756969384 | Destabilising | -2.068 | Destabilising | -0.3526001705029838 | 0 | 0.0 | - | loop | -0.9333333333333332 | 9.57 | VAL | -0.711 | -0.585667215815486 | 8 | 8 | -0.827 | -0.615 | 8:7 | 146/150 | I:C:L:V:M | 61 | 0.6421052631578947 | 80 | effect | pnca_p.val9ala | 0.0002156101768003 | -9.98760797391819 | 4.59660271789382e-05 | 0.930014323968985 | 113.719344729607 | -0.0878268160765962 | 127.948735098955 | 0.807902480033628 | -0.0926410587047397 | 0.0 | 1.0 | 0.0 | 0.0 | 11.7369754738005 | 0.000393645565148 | 0.984170607395186 | -2.01 | -0.5261780104712042 | Destabilising | ALA | 0 | pnca_complex.pdb | |
| 32 | Q10P | Q | 10 | P | A | PZA | 6.02 | -0.631 | Destabilising | -1.771 | Destabilising | -0.1630490956072351 | -0.4485815602836879 | Q10 | QA10 | 6.78299 | 38.0 | -2.0 | 0.0 | 0.0 | -2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 6.0 | 2.0 | 4.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -8.0 | 2.0 | -6.0 | -4.0 | 0.0 | 0.0 | 2.0 | 0.0 | 0.24705126057153678 | Destabilising | -2.963 | Destabilising | -0.5052003410059676 | 0 | 0.0 | B | strand | -0.9333333333333332 | 8.14 | GLN | -1.214 | -1.0 | 9 | 9 | -1.229 | -1.201 | 9:9 | 147/150 | Q | 95 | 1.0 | 95 | effect | pnca_p.gln10pro | 0.0211297973264338 | 5.05135310548255 | 156.233722233267 | 2.4956221564878496e-55 | 0.322395320006857 | 15.6681961306855 | 87.7376148601903 | 314.979076956589 | 156.233890214797 | 2.19377524680641 | 156.382472756358 | 1.2782291871021599e-207 | 206.893391269988 | 83.6783303393677 | 330.782028899935 | 1333.51093453962 | 5.90060424845557e-292 | -0.11 | -0.0287958115183246 | Destabilising | PRO | 0 | pnca_complex.pdb |
| 33 | Q10H | Q | 10 | H | A | PZA | 6.02 | -1.024 | Destabilising | -0.636 | Destabilising | -0.2645994832041343 | -0.1610942249240121 | Q10 | QA10 | 3.94633 | 4.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.0 | 0.0 | 2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -11.0 | 0.0 | -8.0 | -3.0 | 0.0 | 0.0 | 2.0 | 2.0 | 0.1437339287145157 | Destabilising | -1.814 | Destabilising | -0.3092924126172208 | 0 | 0.0 | B | strand | -0.9333333333333332 | 8.14 | GLN | -1.214 | -1.0 | 9 | 9 | -1.229 | -1.201 | 9:9 | 147/150 | Q | 91 | 0.9578947368421052 | 95 | effect | pnca_p.gln10his | 0.0007905706482679 | 15.1494066679727 | 3795803.48336072 | 0.925233417916174 | 161.432542878774 | 0.0938435732834176 | 24.1993753469043 | 107.166385135135 | 2.03005858162844 | inf | 3.5812015819156903e-09 | 8.44597123233921 | 12.2081619622864 | inf | 47.6847963834956 | 5.0055851012886495e-12 | -0.97 | -0.2539267015706806 | Destabilising | HIS | 0 | pnca_complex.pdb | |
| 34 | Q10E | Q | 10 | E | A | PZA | 6.02 | -2.051 | Destabilising | -0.537 | Destabilising | -0.5299741602067184 | -0.1360182370820668 | Q10 | QA10 | 3.84692 | 0.0 | -56.0 | 0.0 | 0.0 | -56.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.0 | -2.0 | 0.0 | 0.0 | 0.0 | 0.0 | -4.0 | 0.0 | -6.0 | 1.0 | 0.0 | 0.0 | 0.0 | 4.0 | 0.1401132001252923 | Destabilising | -1.976 | Destabilising | -0.3369138959931799 | 0 | 0.0 | B | strand | -0.9333333333333332 | 8.14 | GLN | -1.214 | -1.0 | 9 | 9 | -1.229 | -1.201 | 9:9 | 147/150 | Q | 88 | 0.9263157894736842 | 91 | effect | -0.13 | -0.0340314136125654 | Destabilising | GLU | 0 | pnca_complex.pdb | ||||||||||||||||||
| 35 | Q10R | Q | 10 | R | A | PZA | 6.02 | -1.078 | Destabilising | -0.833 | Destabilising | -0.2785529715762274 | -0.2109929078014184 | Q10 | QA10 | 8.553410000000001 | -48.0 | -32.0 | 0.0 | 0.0 | -32.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.0 | 0.0 | 2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -5.0 | 0.0 | -5.0 | -5.0 | 0.0 | 0.0 | 6.0 | -4.0 | 0.31153381070666314 | Destabilising | -2.07 | Destabilising | -0.3529411764705882 | 0 | 0.0 | B | strand | -0.9333333333333332 | 8.14 | GLN | -1.214 | -1.0 | 9 | 9 | -1.229 | -1.201 | 9:9 | 147/150 | Q | 94 | 0.9894736842105263 | 95 | effect | pnca_p.gln10arg | 0.001293661060802 | 4.41895722469024 | 83.0096797665738 | 1.61039699449321e-05 | 1.02456224249978 | 4.31301978678098 | 17.0476857395373 | 1496.24228456829 | 83.0135478408129 | 1.91914897517566 | 82.9817212776157 | 1.31421065040623e-12 | 11.8813350175945 | 12.9924324330291 | 3402.15298704802 | 70.7034697627924 | 4.15161653132659e-17 | -0.42 | -0.1099476439790576 | Destabilising | ARG | 0 | pnca_complex.pdb |
| 36 | Q10L | Q | 10 | L | A | PZA | 6.02 | 0.6409999999999999 | Stabilising | -1.694 | Destabilising | 0.5450680272108843 | -0.4290780141843971 | Q10 | QA10 | 0.169275 | 20.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 4.0 | 0.0 | 4.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -3.0 | 0.0 | -3.0 | -3.0 | 2.0 | 0.0 | 6.0 | 4.0 | 0.006165363966812113 | Destabilising | -0.188 | Destabilising | -0.03205456095481671 | 0 | 0.0 | B | strand | -0.9333333333333332 | 8.14 | GLN | -1.214 | -1.0 | 9 | 9 | -1.229 | -1.201 | 9:9 | 147/150 | Q | 91 | 0.9578947368421052 | 95 | effect | 0.05 | 0.0280898876404494 | Stabilising | LEU | 0 | pnca_complex.pdb | ||||||||||||||||||
| 37 | N11S | N | 11 | S | A | PZA | 9.599 | 0.315 | Stabilising | -1.515 | Destabilising | 0.2678571428571428 | -0.3837386018237081 | N11 | NA11 | 2.58536 | 4.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.0 | 0.0 | 2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -2.0 | 0.0 | 0.0 | -2.0 | 0.0 | 0.0 | -2.0 | 0.0 | 0.09416443884352305 | Destabilising | -1.389 | Destabilising | -0.23682864450127877 | 42 | 0.2153846153846154 | G | helix | -3.5 | 4.28 | ASN | -0.682 | -0.5617792421746294 | 8 | 8 | -0.827 | -0.615 | 8:7 | 147/150 | T:P:L:N:V:I:R:K:Y:E:H:Q | 69 | 0.7263157894736842 | 80 | effect | pnca_p.asn11ser | 7.18700589334483e-05 | -8.98740878149641 | 0.0001249735077034 | 0.940032862253633 | 119.46804443549 | -0.0752285585987755 | 4692673.51081015 | 2.42412778478352 | 0.384555509373631 | 0.0 | 1.0 | 0.0 | 0.0 | 188.544222231268 | 1.0341007080334399e-29 | 0.999999999999997 | 0.57 | 0.3202247191011235 | Stabilising | SER | 0 | pnca_complex.pdb | |
| 38 | D12E | D | 12 | E | A | PZA | 7.825 | -0.21 | Destabilising | -0.42 | Destabilising | -0.0542635658914728 | -0.1063829787234042 | D12 | DA12 | 2.1586 | -8.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.0 | 0.0 | 2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -3.0 | 0.0 | -3.0 | -2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.07862091070010707 | Destabilising | -2.035 | Destabilising | -0.34697357203751067 | 22 | 0.1139896373056994 | G | helix | -1.4 | 5.01 | ASP | -1.058 | -0.8714991762767711 | 9 | 9 | -1.124 | -1.028 | 9:9 | 147/150 | C:D:T:G | 69 | 0.7263157894736842 | 80 | effect | pnca_p.asp12glu | 0.0005749604714675 | 3.52746542085928 | 34.0375872334386 | 0.0009482725856347 | 1.06716956280854 | 3.30544043214259 | 6.05331233477717 | 636.464952477748 | 34.0379426644182 | 1.53196330239691 | 34.0436365315203 | 2.88610345466244e-05 | 4.53968810533409 | 4.36820226973726 | 1521.29182901896 | 23.2409378193551 | 1.42922316872435e-06 | -0.02 | -0.0052356020942408 | Destabilising | GLU | 0 | pnca_complex.pdb |
| 39 | D12Y | D | 12 | Y | A | PZA | 7.825 | -0.794 | Destabilising | -1.94 | Destabilising | -0.2051679586563307 | -0.4913880445795339 | D12 | DA12 | 4.93098 | -30.0 | 16.0 | 0.0 | 0.0 | 16.0 | 0.0 | 0.0 | 0.0 | 0.0 | 4.0 | 0.0 | 4.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -7.0 | 0.0 | -7.0 | -2.0 | 0.0 | 0.0 | 0.0 | -6.0 | 0.1795970250366043 | Destabilising | -1.092 | Destabilising | -0.18618925831202046 | 22 | 0.1139896373056994 | G | helix | -1.4 | 5.01 | ASP | -1.058 | -0.8714991762767711 | 9 | 9 | -1.124 | -1.028 | 9:9 | 147/150 | C:D:T:G | 82 | 0.8631578947368421 | 91 | effect | -0.59 | -0.1544502617801047 | Destabilising | TYR | 0 | pnca_complex.pdb | ||||||||||||||||||
| 40 | D12G | D | 12 | G | A | PZA | 7.825 | 0.079 | Stabilising | -3.008 | Destabilising | 0.0671768707482993 | -0.7619047619047619 | D12 | DA12 | 2.26095 | 20.0 | 16.0 | 0.0 | 0.0 | 16.0 | 0.0 | 0.0 | 0.0 | 0.0 | 4.0 | 0.0 | 4.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 6.0 | 0.0 | 15.0 | 17.0 | 0.0823487204889313 | Destabilising | -1.546 | Destabilising | -0.26359761295822676 | 22 | 0.1139896373056994 | G | helix | -1.4 | 5.01 | ASP | -1.058 | -0.8714991762767711 | 9 | 9 | -1.124 | -1.028 | 9:9 | 147/150 | C:D:T:G | 67 | 0.7052631578947368 | 80 | effect | pnca_p.asp12gly | 0.0005030904125341 | 3.37290329402598 | 29.1630732435187 | 0.001789077082818 | 1.07995768762031 | 3.12318096596747 | 4.97876379053956 | 550.894323519286 | 29.1630847029077 | 1.46483345924118 | 29.1293325978315 | 0.0001485295621003 | 3.828187099348 | 3.53443753556636 | 1331.56873199938 | 18.6717493808583 | 1.55265977742841e-05 | 0.46 | 0.2584269662921348 | Stabilising | GLY | 0 | pnca_complex.pdb |
| 41 | D12A | D | 12 | A | A | PZA | 7.825 | 0.904 | Stabilising | -2.924 | Destabilising | 0.7687074829931974 | -0.7406281661600811 | D12 | DA12 | 0.896575 | 14.0 | 16.0 | 0.0 | 0.0 | 16.0 | 0.0 | 0.0 | 0.0 | 0.0 | 4.0 | 0.0 | 4.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 4.0 | 0.0 | 6.0 | 3.0 | 0.03265521310615608 | Destabilising | -1.267 | Destabilising | -0.21602728047740832 | 22 | 0.1139896373056994 | G | helix | -1.4 | 5.01 | ASP | -1.058 | -0.8714991762767711 | 9 | 9 | -1.124 | -1.028 | 9:9 | 147/150 | C:D:T:G | 64 | 0.6736842105263158 | 80 | effect | pnca_p.asp12ala | 0.0017967514733362 | 1.66318697401976 | 5.27609886875925 | 3.35314758209503e-05 | 0.400956055116994 | 4.14805301676878 | 2.39021356042842 | 11.7435962131774 | 5.2760989010989 | 0.722312927852139 | 5.2752786493537 | 6.93631068428177e-05 | 4.15887146261268 | 2.21601547098056 | 12.6651520546836 | 19.1276037177328 | 1.22263744860911e-05 | 1.36 | 0.7640449438202248 | Stabilising | ALA | 0 | pnca_complex.pdb |
| 42 | D12N | D | 12 | N | A | PZA | 7.825 | 0.018 | Stabilising | -1.928 | Destabilising | 0.0153061224489795 | -0.4883485309017224 | D12 | DA12 | 1.58277 | 0.0 | 16.0 | 0.0 | 0.0 | 16.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.0 | 0.0 | 2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -7.0 | 0.0 | -5.0 | -2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.05764792867080908 | Destabilising | -2.236 | Destabilising | -0.3812446717817562 | 22 | 0.1139896373056994 | G | helix | -1.4 | 5.01 | ASP | -1.058 | -0.8714991762767711 | 9 | 9 | -1.124 | -1.028 | 9:9 | 147/150 | C:D:T:G | 79 | 0.8315789473684211 | 85 | effect | pnca_p.asp12asn | 0.000646830530401 | 2.83423972614077 | 17.0174574529133 | 0.0004057565735776 | 0.801467871651648 | 3.53631109416779 | 4.11022012991606 | 114.25813127402 | 17.0174957841484 | 1.23089565168614 | 17.0076332291246 | 0.0001105447439914 | 3.95646190174896 | 3.23648804294829 | 167.757055506696 | 19.306440114962 | 1.11330211002346e-05 | 0.09 | 0.0505617977528089 | Stabilising | ASN | 0 | pnca_complex.pdb |
| 43 | F13C | F | 13 | C | A | PZA | 3.551 | -2.32 | Destabilising | -0.485 | Destabilising | -0.5994832041343668 | -0.1228470111448834 | F13 | FA13 | 2.69734 | 42.0 | 4.0 | 0.0 | 0.0 | 4.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -7.0 | 0.0 | -5.0 | -2.0 | -2.0 | 0.0 | -2.0 | 0.0 | 0.09824299419430503 | Destabilising | -2.036 | Destabilising | -0.3471440750213129 | 24 | 0.1 | G | helix | 0.6 | 6.93 | PHE | -1.201 | -0.9892915980230643 | 9 | 9 | -1.229 | -1.201 | 9:9 | 147/150 | F | 79 | 0.8315789473684211 | 85 | effect | pnca_p.phe13cys | 0.0001437401178668 | -9.98752126245058 | 4.59700131334268e-05 | 0.942832958100734 | 139.277183325397 | -0.0717096729269463 | 144471.706314842 | 1.2119588062211 | 0.0834878586628579 | 0.0 | 1.0 | 0.0 | 0.0 | 25.8386585962163 | 1.0105682238915901e-25 | 0.999999999999746 | -2.68 | -0.7015706806282723 | Destabilising | CYS | 0 | pnca_complex.pdb | |
| 44 | F13L | F | 13 | L | A | PZA | 3.551 | -2.033 | Destabilising | -0.427 | Destabilising | -0.5253229974160206 | -0.1081560283687943 | F13 | FA13 | 1.0968 | 8.0 | 6.0 | 0.0 | 0.0 | 6.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -4.0 | 0.0 | -2.0 | -4.0 | -4.0 | 0.0 | -2.0 | 0.0 | 0.03994784344291552 | Destabilising | -1.283 | Destabilising | -0.2187553282182438 | 24 | 0.1 | G | helix | 0.6 | 6.93 | PHE | -1.201 | -0.9892915980230643 | 9 | 9 | -1.229 | -1.201 | 9:9 | 147/150 | F | 84 | 0.8842105263157894 | 91 | effect | pnca_p.phe13leu | 0.0005749604714675 | 3.52746542085928 | 34.0375872334388 | 0.0009482725856346 | 1.06716956280854 | 3.3054404321426 | 6.05331233477459 | 636.464952476757 | 34.0379426644182 | 1.53196330239691 | 34.0436365315203 | 2.88610345466244e-05 | 4.53968810533409 | 4.36820226973726 | 1521.29182901896 | 23.2409378193551 | 1.42922316872435e-06 | -2.06 | -0.5392670157068064 | Destabilising | LEU | 0 | pnca_complex.pdb |
| 45 | F13I | F | 13 | I | A | PZA | 3.551 | -1.7619999999999998 | Destabilising | -0.45 | Destabilising | -0.4552971576227389 | -0.1139817629179331 | F13 | FA13 | 0.8872450000000001 | 12.0 | 8.0 | 0.0 | 0.0 | 8.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -7.0 | 0.0 | -3.0 | -4.0 | 4.0 | 0.0 | 2.0 | 4.0 | 0.03231539419721881 | Destabilising | -1.241 | Destabilising | -0.21159420289855074 | 24 | 0.1 | G | helix | 0.6 | 6.93 | PHE | -1.201 | -0.9892915980230643 | 9 | 9 | -1.229 | -1.201 | 9:9 | 147/150 | F | 83 | 0.8736842105263158 | 91 | effect | pnca_p.phe13ile | 0.0002874802357337 | 2.67848962960141 | 14.5630810302277 | 0.0202679102821363 | 1.15384949648317 | 2.3213509541454 | 1.86363317860665 | 294.488177945996 | 14.5631313131313 | 1.16325476548539 | 14.5631012253236 | 0.0174140488202037 | 1.75910024233227 | 1.16837785201846 | 760.989759542733 | 5.81873994206135 | 0.0158563003544608 | -2.3 | -0.6020942408376964 | Destabilising | ILE | 0 | pnca_complex.pdb |
| 46 | F13S | F | 13 | S | A | PZA | 3.551 | -3.104 | Destabilising | 0.218 | Stabilising | -0.8020671834625321 | 0.0977578475336322 | F13 | FA13 | 2.59174 | 44.0 | 6.0 | 0.0 | 0.0 | 6.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -9.0 | 0.0 | -5.0 | -4.0 | -2.0 | 0.0 | 2.0 | 6.0 | 0.09439681233109216 | Destabilising | -2.032 | Destabilising | -0.346462063086104 | 24 | 0.1 | G | helix | 0.6 | 6.93 | PHE | -1.201 | -0.9892915980230643 | 9 | 9 | -1.229 | -1.201 | 9:9 | 147/150 | F | 88 | 0.9263157894736842 | 91 | effect | pnca_p.phe13ser | 0.0002874802357337 | 0.480257130287146 | 1.61648999729673 | 0.677247786834331 | 1.1538493489906 | 0.416221693678883 | 0.0799389646160496 | 12.6318165284589 | 1.61648444070648 | 0.208571528713835 | 1.61641362774286 | 0.527693668101443 | 0.277618116975238 | 0.0307788891197694 | 20.1401594005 | 5.751485287704321e-25 | 0.999999999999395 | -3.54 | -0.9267015706806284 | Destabilising | SER | 0 | pnca_complex.pdb |
| 47 | F13V | F | 13 | V | A | PZA | 3.551 | -2.57 | Destabilising | -0.562 | Destabilising | -0.6640826873385013 | -0.1423505572441742 | F13 | FA13 | 1.40193 | 44.0 | 8.0 | 0.0 | 0.0 | 8.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.0 | 0.0 | 2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -1.0 | 0.0 | -1.0 | 0.0 | 0.0 | 0.0 | -4.0 | 0.0 | 0.05106134223005703 | Destabilising | -2.51 | Destabilising | -0.42796248934356346 | 24 | 0.1 | G | helix | 0.6 | 6.93 | PHE | -1.201 | -0.9892915980230643 | 9 | 9 | -1.229 | -1.201 | 9:9 | 147/150 | F | 84 | 0.8842105263157894 | 91 | effect | pnca_p.phe13val | 0.0001437401178668 | -9.98752126245058 | 4.59700131334268e-05 | 0.942832958100734 | 139.277183325397 | -0.0717096729269463 | 144471.706314842 | 1.2119588062211 | 0.0834878586628579 | 0.0 | 1.0 | 0.0 | 0.0 | 25.8386585962163 | 1.0105682238915901e-25 | 0.999999999999746 | -2.34 | -0.612565445026178 | Destabilising | VAL | 0 | pnca_complex.pdb | |
| 48 | C14Y | C | 14 | Y | A | PZA | 8.493 | -0.931 | Destabilising | -0.604 | Destabilising | -0.2405684754521963 | -0.1529888551165147 | C14 | CA14 | -0.852908 | -40.0 | -2.0 | 0.0 | 0.0 | -2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -5.0 | 0.0 | -3.0 | -2.0 | 0.0 | 0.0 | 0.0 | -2.0 | -0.16398292701684228 | Stabilising | -1.613 | Destabilising | -0.27502131287297527 | 1 | 0.0059880239520958 | S | loop | 0.6 | 5.76 | CYS | 0.013 | 0.004166666666666667 | 5 | 5 | -0.244 | 0.225 | 6:4 | 147/150 | L:V:C:I:M:A:T | 73 | 0.7684210526315789 | 85 | effect | pnca_p.cys14tyr | 0.0001437401178668 | 1.57903938912402 | 4.85029432717734 | 0.264247566376723 | 1.41439286276584 | 1.11640791656443 | 0.191756076673665 | 122.683760399245 | 4.85029436501262 | 0.685768096792206 | 4.84956447904112 | 0.312734154310187 | 0.504824686014995 | 0.061763864579114 | 379.558337204203 | 0.0881192621863332 | 0.766581879696361 | -0.51 | -0.1335078534031413 | Destabilising | TYR | 0 | pnca_complex.pdb |
| 49 | C14G | C | 14 | G | A | PZA | 8.493 | -0.534 | Destabilising | -1.214 | Destabilising | -0.137984496124031 | -0.3074974670719351 | C14 | CA14 | 1.40101 | 10.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.0 | -2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 4.0 | 0.0 | 4.0 | 2.0 | 4.0 | 0.0 | 13.0 | 15.0 | 0.051027833827460865 | Destabilising | -2.618 | Destabilising | -0.44637681159420284 | 1 | 0.0059880239520958 | S | loop | 0.6 | 5.76 | CYS | 0.013 | 0.004166666666666667 | 5 | 5 | -0.244 | 0.225 | 6:4 | 147/150 | L:V:C:I:M:A:T | 82 | 0.8631578947368421 | 91 | effect | pnca_p.cys14gly | 0.0009343107661348 | 1.42647319438274 | 4.16398768969361 | 0.0104102993024226 | 0.556804076010637 | 2.56189431047824 | 1.33944091330526 | 12.5461379903288 | 4.1639877189814 | 0.619509439957981 | 4.16339464867528 | 0.0142886927095374 | 1.84500750353971 | 1.15481122214044 | 14.4829286214949 | 5.83418569155344 | 0.0157176829434794 | 1.21 | 0.6797752808988764 | Stabilising | GLY | 0 | pnca_complex.pdb |
| 50 | C14R | C | 14 | R | A | PZA | 8.493 | -0.3329999999999999 | Destabilising | -1.215 | Destabilising | -0.0860465116279069 | -0.3077507598784195 | C14 | CA14 | -1.79171 | -58.0 | -18.0 | 0.0 | 0.0 | -18.0 | 0.0 | 0.0 | 0.0 | 0.0 | -4.0 | 0.0 | -2.0 | -2.0 | 0.0 | 0.0 | 0.0 | 0.0 | -5.0 | 0.0 | -2.0 | -3.0 | 0.0 | 0.0 | -2.0 | -2.0 | -0.34448011997231404 | Stabilising | -2.708 | Destabilising | -0.4617220801364024 | 1 | 0.0059880239520958 | S | loop | 0.6 | 5.76 | CYS | 0.013 | 0.004166666666666667 | 5 | 5 | -0.244 | 0.225 | 6:4 | 147/150 | L:V:C:I:M:A:T | 81 | 0.8526315789473684 | 91 | effect | pnca_p.cys14arg | 0.0034497628288055 | 3.74827446550197 | 42.4477736723918 | 2.29709370000913e-15 | 0.473019029416408 | 7.92415152964658 | 18.4724160727947 | 122.828725767578 | 42.4477739726027 | 1.6278549200979 | 42.4422996313437 | 5.27268754098056e-28 | 27.2779679641604 | 16.8169087404394 | 137.378365631042 | 173.445422378416 | 1.30826250297363e-39 | 0.11 | 0.0617977528089887 | Stabilising | ARG | 0 | pnca_complex.pdb |
| 51 | C14W | C | 14 | W | A | PZA | 8.493 | -1.426 | Destabilising | -0.421 | Destabilising | -0.3684754521963824 | -0.1066362715298885 | C14 | CA14 | 3.5671800000000005 | -40.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -2.0 | 0.0 | -2.0 | -4.0 | 0.0 | 0.0 | 0.0 | -2.0 | 0.1299244604054517 | Destabilising | -1.443 | Destabilising | -0.24603580562659846 | 1 | 0.0059880239520958 | S | loop | 0.6 | 5.76 | CYS | 0.013 | 0.004166666666666667 | 5 | 5 | -0.244 | 0.225 | 6:4 | 147/150 | L:V:C:I:M:A:T | 81 | 0.8526315789473684 | 91 | effect | pnca_p.cys14trp | 0.0002156101768003 | 2.27260607808817 | 9.70465898653051 | 0.0634455902260898 | 1.22442760158496 | 1.8560559033024 | 0.929172866365548 | 208.881603004778 | 9.70466975178797 | 0.986980761010679 | 9.70194990589383 | 0.0776844925942494 | 1.10966566656461 | 0.504888890842109 | 570.372842410328 | 2.29168245016684 | 0.130068862702538 | -1.01 | -0.2643979057591623 | Destabilising | TRP | 0 | pnca_complex.pdb |
| 52 | E15D | E | 15 | D | A | PZA | 11.854 | -0.135 | Destabilising | 0.146 | Stabilising | -0.0348837209302325 | 0.0654708520179372 | E15 | EA15 | 2.38936 | 10.0 | 4.0 | 0.0 | 0.0 | 4.0 | 0.0 | 0.0 | 0.0 | 0.0 | 7.0 | 0.0 | 7.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 4.0 | 0.0 | 2.0 | 2.0 | 0.0 | 0.0 | 2.0 | -4.0 | 0.08702569220346884 | Destabilising | -0.543 | Destabilising | -0.09258312020460359 | 92 | 0.4125560538116592 | T | loop | -0.4666666666666666 | 3.7 | GLU | -0.898 | -0.7397034596375618 | 8 | 8 | -0.993 | -0.827 | 9:8 | 146/150 | H:A:S:E:P:D | -31 | -0.3333333333333333 | 66 | neutral | -0.05 | -0.013089005235602 | Destabilising | ASP | 0 | pnca_complex.pdb | ||||||||||||||||||
| 53 | E15G | E | 15 | G | A | PZA | 11.854 | 0.063 | Stabilising | -0.81 | Destabilising | 0.0535714285714285 | -0.2051671732522796 | E15 | EA15 | 2.82636 | 16.0 | 10.0 | 0.0 | 0.0 | 10.0 | 0.0 | 0.0 | 0.0 | 0.0 | 7.0 | 0.0 | 7.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 4.0 | 0.0 | 2.0 | 2.0 | 0.0 | 0.0 | 11.0 | 5.0 | 0.10294218343665092 | Destabilising | -0.925 | Destabilising | -0.1577152600170503 | 92 | 0.4125560538116592 | T | loop | -0.4666666666666666 | 3.7 | GLU | -0.898 | -0.7397034596375618 | 8 | 8 | -0.993 | -0.827 | 9:8 | 146/150 | H:A:S:E:P:D | 66 | 0.6947368421052632 | 80 | effect | pnca_p.glu15gly | 0.0003593502946672 | -10.9877909019995 | 1.69068633684896e-05 | 0.939691219428539 | 145.22979768191 | -0.075657964669658 | 60.3389082676129 | 0.484657419083649 | -0.314565134742567 | 0.0 | 0.596111875058711 | 0.224672226566594 | 0.0 | 5.29224350433385 | 0.177777263899814 | 0.673290424524484 | 0.47 | 0.2640449438202247 | Stabilising | GLY | 0 | pnca_complex.pdb | |
| 54 | G17A | G | 17 | A | A | PZA | 11.288 | -0.03 | Destabilising | -0.016 | Destabilising | -0.0077519379844961 | -0.0040526849037487 | G17 | GA17 | 4.40656 | -6.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.0 | 0.0 | 2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -2.0 | 0.0 | -4.0 | 2.0 | -6.0 | 0.0 | -13.0 | -18.0 | 0.1604965071132511 | Destabilising | -1.942 | Destabilising | -0.3311167945439045 | 18 | 0.173076923076923 | S | loop | -0.5333333333333333 | 3.87 | GLY | -1.147 | -0.9448105436573312 | 9 | 9 | -1.221 | -1.124 | 9:9 | 147/150 | R:G | 66 | 0.6947368421052632 | 80 | effect | pnca_p.gly17ala | 7.18700589334483e-05 | 12.1451538387262 | 188179.926264583 | 0.919026337424224 | 119.468044436215 | 0.101660271548268 | 5.01153666064308e-06 | 9.70142977291842 | 0.986835744238421 | inf | 0.170978870202674 | 0.767057556984365 | 0.124324963210678 | inf | 0.763784339928386 | 0.382146811758261 | -0.17 | -0.0445026178010471 | Destabilising | ALA | 0 | pnca_complex.pdb | |
| 55 | G17R | G | 17 | R | A | PZA | 11.288 | -0.0579999999999999 | Destabilising | 0.099 | Stabilising | -0.0149870801033591 | 0.0443946188340807 | G17 | GA17 | 13.8675 | -74.0 | -16.0 | 0.0 | 0.0 | -16.0 | 0.0 | 0.0 | 0.0 | 0.0 | -2.0 | 0.0 | -2.0 | -2.0 | 0.0 | 0.0 | 0.0 | 0.0 | -7.0 | 0.0 | -7.0 | -5.0 | -10.0 | 0.0 | -13.0 | -21.0 | 0.5050845358722018 | Destabilising | -2.189 | Destabilising | -0.373231031543052 | 18 | 0.173076923076923 | S | loop | -0.5333333333333333 | 3.87 | GLY | -1.147 | -0.9448105436573312 | 9 | 9 | -1.221 | -1.124 | 9:9 | 147/150 | R:G | 86 | 0.9052631578947369 | 91 | effect | pnca_p.gly17arg | 7.18700589334483e-05 | 12.1451538387266 | 188179.926264663 | 0.919026337424239 | 119.468044436241 | 0.10166027154825 | 5.0115366606189e-06 | 9.70142977291842 | 0.986835744238421 | inf | 0.170978870202674 | 0.767057556984365 | 0.124324963210678 | inf | 0.763784339928386 | 0.382146811758261 | 0.01 | 0.0056179775280898 | Stabilising | ARG | 0 | pnca_complex.pdb | |
| 56 | G17D | G | 17 | D | A | PZA | 11.288 | -0.552 | Destabilising | 1.6780000000000002 | Stabilising | -0.1426356589147286 | 0.7524663677130046 | G17 | GA17 | 15.5901 | -26.0 | -26.0 | 0.0 | 0.0 | -26.0 | 0.0 | 0.0 | 0.0 | 0.0 | -2.0 | 0.0 | -4.0 | -2.0 | 0.0 | 0.0 | 0.0 | 0.0 | -6.0 | 0.0 | -6.0 | -2.0 | -6.0 | 0.0 | -11.0 | -21.0 | 0.5678253775158618 | Destabilising | -2.984 | Destabilising | -0.5087809036658141 | 18 | 0.173076923076923 | S | loop | -0.5333333333333333 | 3.87 | GLY | -1.147 | -0.9448105436573312 | 9 | 9 | -1.221 | -1.124 | 9:9 | 147/150 | R:G | 78 | 0.8210526315789474 | 85 | effect | pnca_p.gly17asp | 0.0003593502946672 | 2.96659528728018 | 19.4256680571767 | 0.0079500503166054 | 1.11770528264822 | 2.65418382943607 | 2.87215213651461 | 380.0971589756 | 19.4256842105263 | 1.28837632444196 | 19.4169790983636 | 0.0036816889015929 | 2.43395291165754 | 1.92061868691892 | 951.403114304703 | 9.87561363723508 | 0.0016748373055023 | -0.05 | -0.013089005235602 | Destabilising | ASP | 0 | pnca_complex.pdb |
| 57 | G17S | G | 17 | S | A | PZA | 11.288 | -0.437 | Destabilising | 0.598 | Stabilising | -0.1129198966408268 | 0.2681614349775785 | G17 | GA17 | 8.97262 | -6.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -2.0 | 0.0 | -2.0 | -2.0 | 0.0 | 0.0 | 0.0 | 0.0 | -7.0 | 0.0 | -7.0 | 0.0 | -4.0 | 0.0 | -11.0 | -19.0 | 0.32680235141573 | Destabilising | -1.946 | Destabilising | -0.33179880647911336 | 18 | 0.173076923076923 | S | loop | -0.5333333333333333 | 3.87 | GLY | -1.147 | -0.9448105436573312 | 9 | 9 | -1.221 | -1.124 | 9:9 | 147/150 | R:G | 68 | 0.7157894736842105 | 80 | effect | pnca_p.gly17ser | 0.0002156101768003 | 0.885806606247281 | 2.4249395742581 | 0.469406216824826 | 1.22442753211922 | 0.723445514749362 | 0.112662937620391 | 25.327054747117 | 2.42493692178301 | 0.384700446081433 | 2.42473736947533 | 0.430258985168156 | 0.366270051463612 | 0.0410854444106247 | 46.5881472867033 | 4.31445715363782e-25 | 0.999999999999476 | -0.26 | -0.0680628272251308 | Destabilising | SER | 0 | pnca_complex.pdb |
| 58 | S18P | S | 18 | P | A | PZA | 9.173 | -0.521 | Destabilising | -1.13 | Destabilising | -0.134625322997416 | -0.2862208713272542 | S18 | SA18 | 1.09268 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 4.0 | 0.0 | 4.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -4.0 | 2.0 | -6.0 | -2.0 | -2.0 | 0.0 | -8.0 | 0.0 | 0.039797784074767445 | Destabilising | 0.064 | Stabilising | 0.05405405405405406 | 53 | 0.3419354838709677 | T | loop | 0.8666666666666666 | 3.72 | SER | -0.553 | -0.4555189456342669 | 7 | 7 | -0.674 | -0.485 | 7:7 | 147/150 | T:S:A:R:K:N:H:E | 53 | 0.5578947368421052 | 75 | effect | pnca_p.ser18pro | 7.18700589334483e-05 | -8.9874087814964 | 0.0001249735077034 | 0.940032862253632 | 119.468044435489 | -0.0752285585987761 | 4692673.51081157 | 2.42412778478352 | 0.384555509373631 | 0.0 | 1.0 | 0.0 | 0.0 | 188.544222231268 | 1.0341007080334399e-29 | 0.999999999999997 | -0.16 | -0.0418848167539267 | Destabilising | PRO | 0 | pnca_complex.pdb | |
| 59 | L19V | L | 19 | V | A | PZA | 5.113 | -2.048 | Destabilising | -1.722 | Destabilising | -0.5291989664082687 | -0.4361702127659574 | L19 | LA19 | 1.25265 | 26.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -2.0 | 0.0 | -2.0 | -1.0 | -2.0 | 0.0 | 0.0 | -2.0 | 0.04562423968706066 | Destabilising | -1.307 | Destabilising | -0.222847399829497 | 27 | 0.1343283582089552 | T | loop | 1.6 | 4.47 | LEU | -1.173 | -0.9662273476112027 | 9 | 9 | -1.221 | -1.152 | 9:9 | 147/150 | L:V | 7 | 0.07368421052631578 | 53 | effect | pnca_p.leu19val | 7.18700589334483e-05 | -8.98740878149641 | 0.0001249735077034 | 0.940032862253633 | 119.46804443549 | -0.0752285585987759 | 4692673.51081035 | 2.42412778478352 | 0.384555509373631 | 0.0 | 1.0 | 0.0 | 0.0 | 188.544222231268 | 1.0341007080334399e-29 | 0.999999999999997 | -2.23 | -0.5837696335078534 | Destabilising | VAL | 0 | pnca_complex.pdb | |
| 60 | L19R | L | 19 | R | A | PZA | 5.113 | -1.418 | Destabilising | -0.665 | Destabilising | -0.3664082687338502 | -0.1684397163120567 | L19 | LA19 | 2.62574 | -54.0 | -30.0 | 0.0 | 0.0 | -30.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.0 | 0.0 | -1.0 | 2.0 | -4.0 | 0.0 | 0.0 | -8.0 | 0.09563516634008115 | Destabilising | -1.398 | Destabilising | -0.2383631713554987 | 27 | 0.1343283582089552 | T | loop | 1.6 | 4.47 | LEU | -1.173 | -0.9662273476112027 | 9 | 9 | -1.221 | -1.152 | 9:9 | 147/150 | L:V | 81 | 0.8526315789473684 | 91 | effect | pnca_p.leu19arg | 0.0002156101768003 | 2.27260607808817 | 9.70465898653051 | 0.0634455902260897 | 1.22442760158496 | 1.8560559033024 | 0.929172866364976 | 208.881603004981 | 9.70466975178797 | 0.986980761010679 | 9.70194990589383 | 0.0776844925942494 | 1.10966566656461 | 0.504888890842109 | 570.372842410328 | 2.29168245016684 | 0.130068862702538 | -0.57 | -0.1492146596858638 | Destabilising | ARG | 0 | pnca_complex.pdb |
| 61 | L19P | L | 19 | P | A | PZA | 5.113 | -1.791 | Destabilising | -1.723 | Destabilising | -0.4627906976744185 | -0.4364235055724417 | L19 | LA19 | 2.98164 | 26.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 7.0 | 6.0 | -1.0 | 1.0 | -4.0 | 0.0 | -2.0 | 0.0 | 0.10859781904005711 | Destabilising | -1.477 | Destabilising | -0.25183290707587386 | 27 | 0.1343283582089552 | T | loop | 1.6 | 4.47 | LEU | -1.173 | -0.9662273476112027 | 9 | 9 | -1.221 | -1.152 | 9:9 | 147/150 | L:V | 83 | 0.8736842105263158 | 91 | effect | pnca_p.leu19pro | 0.0003593502946672 | 2.96659528728018 | 19.4256680571767 | 0.0079500503166053 | 1.11770528264822 | 2.65418382943607 | 2.87215213651493 | 380.09715897553 | 19.4256842105263 | 1.28837632444196 | 19.4169790983636 | 0.0036816889015929 | 2.43395291165754 | 1.92061868691892 | 951.403114304703 | 9.87561363723508 | 0.0016748373055023 | -1.37 | -0.3586387434554974 | Destabilising | PRO | 0 | pnca_complex.pdb |
| 62 | A20P | A | 20 | P | A | PZA | 9.104 | -0.313 | Destabilising | -0.318 | Destabilising | -0.0808785529715762 | -0.080547112462006 | A20 | AA20 | -1.37798 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -4.0 | 2.0 | -6.0 | 0.0 | 0.0 | 0.0 | 0.0 | -3.0 | -0.26493501499653926 | Stabilising | -0.07 | Destabilising | -0.011935208866155159 | 52 | 0.4031007751937984 | - | loop | 3.266666666666667 | 3.81 | ALA | -0.39 | -0.3212520593080725 | 6 | 6 | -0.553 | -0.332 | 7:6 | 147/150 | P:A:S:Y:E:G:H | -76 | -0.8172043010752689 | 87 | neutral | 0.06 | 0.0337078651685393 | Stabilising | PRO | 0 | pnca_complex.pdb | ||||||||||||||||||
| 63 | A20S | A | 20 | S | A | PZA | 9.104 | -0.846 | Destabilising | 0.467 | Stabilising | -0.2186046511627906 | 0.2094170403587444 | A20 | AA20 | -0.127919 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -4.0 | 0.0 | -4.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -3.0 | 0.0 | -3.0 | 0.0 | 0.0 | 0.0 | 0.0 | -1.0 | -0.02459413212335615 | Stabilising | -0.376 | Destabilising | -0.06410912190963342 | 52 | 0.4031007751937984 | - | loop | 3.266666666666667 | 3.81 | ALA | -0.39 | -0.3212520593080725 | 6 | 6 | -0.553 | -0.332 | 7:6 | 147/150 | P:A:S:Y:E:G:H | -46 | -0.4946236559139785 | 72 | neutral | -0.16 | -0.0418848167539267 | Destabilising | SER | 0 | pnca_complex.pdb | ||||||||||||||||||
| 64 | V21G | V | 21 | G | A | PZA | 6.521 | -2.004 | Destabilising | -0.391 | Destabilising | -0.517829457364341 | -0.0990374873353596 | V21 | VA21 | 2.3728700000000003 | 16.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.0 | 0.0 | 11.0 | 15.0 | 0.0864250905091092 | Destabilising | -2.469 | Destabilising | -0.4209718670076726 | 9 | 0.0517241379310344 | - | loop | 1.7666666666666668 | 4.94 | VAL | -1.104 | -0.9093904448105438 | 9 | 9 | -1.178 | -1.062 | 9:9 | 147/150 | T:V:C:I | 70 | 0.7368421052631579 | 85 | effect | pnca_p.val21gly | 0.0004312203536006 | 3.19016080361872 | 24.29233342416 | 0.0035954281300594 | 1.09565968954933 | 2.91163472932996 | 3.91551977432241 | 465.531063220335 | 24.2923336141533 | 1.38546923679232 | 24.2833096922897 | 0.0007494070007895 | 3.12528225414311 | 2.71567844828345 | 1141.60089496884 | 14.1977442691074 | 0.0001645676755807 | -2.8 | -0.7329842931937173 | Destabilising | GLY | 0 | pnca_complex.pdb |
| 65 | V21A | V | 21 | A | A | PZA | 6.521 | -1.742 | Destabilising | -0.327 | Destabilising | -0.4501291989664082 | -0.0828267477203647 | V21 | VA21 | 1.43401 | 4.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -1.0 | 0.0 | -1.0 | 0.0 | 2.0 | 0.0 | 4.0 | 1.0 | 0.052229765659714884 | Destabilising | -1.866 | Destabilising | -0.31815856777493606 | 9 | 0.0517241379310344 | - | loop | 1.7666666666666668 | 4.94 | VAL | -1.104 | -0.9093904448105438 | 9 | 9 | -1.178 | -1.062 | 9:9 | 147/150 | T:V:C:I | 60 | 0.631578947368421 | 80 | effect | pnca_p.val21ala | 0.0001437401178668 | 1.57903938912402 | 4.85029432717736 | 0.264247566376722 | 1.41439286276584 | 1.11640791656443 | 0.191756076673664 | 122.683760399233 | 4.85029436501262 | 0.685768096792206 | 4.84956447904112 | 0.312734154310187 | 0.504824686014995 | 0.061763864579114 | 379.558337204203 | 0.0881192621863332 | 0.766581879696361 | -1.79 | -0.468586387434555 | Destabilising | ALA | 0 | pnca_complex.pdb |
| 66 | V21I | V | 21 | I | A | PZA | 6.521 | -0.748 | Destabilising | -0.188 | Destabilising | -0.19328165374677 | -0.0476190476190476 | V21 | VA21 | -0.568333 | -14.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -2.0 | 0.0 | -2.0 | 0.0 | 0.0 | 0.0 | -2.0 | -2.0 | -0.10926959163270014 | Stabilising | -0.271 | Destabilising | -0.04620630861040068 | 9 | 0.0517241379310344 | - | loop | 1.7666666666666668 | 4.94 | VAL | -1.104 | -0.9093904448105438 | 9 | 9 | -1.178 | -1.062 | 9:9 | 147/150 | T:V:C:I | 30 | 0.3157894736842105 | 66 | effect | -0.56 | -0.1465968586387434 | Destabilising | ILE | 0 | pnca_complex.pdb | ||||||||||||||||||
| 67 | T22P | T | 22 | P | A | PZA | 11.195 | 0.063 | Stabilising | -0.353 | Destabilising | 0.0535714285714285 | -0.0894123606889564 | T22 | TA22 | -1.50027 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -4.0 | -0.28844689686995306 | Stabilising | 0.006 | Stabilising | 0.005067567567567568 | 127 | 0.7383720930232558 | T | loop | 1.0333333333333334 | 3.6 | THR | 1.546 | 0.49551282051282053 | 1 | 1 | 0.842 | 1.712 | 2:1 | 147/150 | T:A:S:G:P:D:H:E:Q:N:K:I:R | -77 | -0.8279569892473119 | 87 | neutral | -0.0 | -0.0 | Stabilising | PRO | 0 | pnca_complex.pdb | ||||||||||||||||||
| 68 | T22A | T | 22 | A | A | PZA | 11.195 | 0.118 | Stabilising | -0.361 | Destabilising | 0.1003401360544217 | -0.0914387031408308 | T22 | TA22 | -0.193269 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.0 | 0.0 | 4.0 | 1.0 | -0.03715854033684534 | Stabilising | 0.057 | Stabilising | 0.04814189189189189 | 127 | 0.7383720930232558 | T | loop | 1.0333333333333334 | 3.6 | THR | 1.546 | 0.49551282051282053 | 1 | 1 | 0.842 | 1.712 | 2:1 | 147/150 | T:A:S:G:P:D:H:E:Q:N:K:I:R | -93 | -1.0 | 97 | neutral | -0.37 | -0.0968586387434555 | Destabilising | ALA | 0 | pnca_complex.pdb | ||||||||||||||||||
| 69 | G23V | G | 23 | V | A | PZA | 11.963 | -0.7809999999999999 | Destabilising | -0.147 | Destabilising | -0.2018087855297157 | -0.0372340425531914 | G23 | GA23 | 2.85361 | -2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -3.0 | 0.0 | -3.0 | 0.0 | -2.0 | 0.0 | -5.0 | -13.0 | 0.10393468775267886 | Destabilising | -2.833 | Destabilising | -0.4830349531116795 | 28 | 0.2692307692307692 | T | loop | -0.5 | 3.83 | GLY | 0.492 | 0.1576923076923077 | 3 | 3 | 0.083 | 0.59 | 5:3 | 147/150 | G:D:H:Y:E:Q:N:R:K | 53 | 0.5578947368421052 | 75 | effect | pnca_p.gly23val | 7.18700589334483e-05 | -8.98740878149641 | 0.0001249735077034 | 0.940032862253633 | 119.468044435491 | -0.0752285585987751 | 4692673.51081314 | 2.42412778478352 | 0.384555509373631 | 0.0 | 1.0 | 0.0 | 0.0 | 188.544222231268 | 1.0341007080334399e-29 | 0.999999999999997 | -1.41 | -0.369109947643979 | Destabilising | VAL | 0 | pnca_complex.pdb | |
| 70 | G24S | G | 24 | S | A | PZA | 10.19 | -1.524 | Destabilising | -0.034 | Destabilising | -0.3937984496124031 | -0.008611955420466 | G24 | GA24 | -0.205598 | -8.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -2.0 | 0.0 | -2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -8.0 | 0.0 | -6.0 | -4.0 | -4.0 | 0.0 | -9.0 | -17.0 | -0.03952895485657156 | Stabilising | -2.078 | Destabilising | -0.35430520034100593 | 0 | 0.0 | H | helix | 0.3333333333333333 | 5.96 | GLY | -0.971 | -0.799835255354201 | 9 | 9 | -1.094 | -0.914 | 9:8 | 147/150 | G:S:A | 41 | 0.43157894736842106 | 71 | effect | pnca_p.gly24ser | 7.18700589334483e-05 | 12.1451538387267 | 188179.926264687 | 0.919026337424243 | 119.468044436249 | 0.101660271548244 | 5.01153666061174e-06 | 9.70142977291842 | 0.986835744238421 | inf | 0.170978870202674 | 0.767057556984365 | 0.124324963210678 | inf | 0.763784339928386 | 0.382146811758261 | -1.03 | -0.2696335078534032 | Destabilising | SER | 0 | pnca_complex.pdb | |
| 71 | G24R | G | 24 | R | A | PZA | 10.19 | -1.19 | Destabilising | -0.978 | Destabilising | -0.3074935400516795 | -0.2477203647416413 | G24 | GA24 | 6.837089999999999 | -64.0 | -30.0 | 0.0 | 0.0 | -30.0 | 0.0 | 0.0 | 0.0 | 0.0 | -2.0 | 0.0 | 0.0 | -2.0 | 0.0 | 0.0 | 0.0 | 0.0 | -9.0 | 0.0 | -3.0 | -11.0 | -14.0 | 0.0 | -17.0 | -29.0 | 0.24902170033289867 | Destabilising | -3.44 | Destabilising | -0.5865302642796248 | 0 | 0.0 | H | helix | 0.3333333333333333 | 5.96 | GLY | -0.971 | -0.799835255354201 | 9 | 9 | -1.094 | -0.914 | 9:8 | 147/150 | G:S:A | 82 | 0.8631578947368421 | 91 | effect | pnca_p.gly24arg | 7.18700589334483e-05 | 12.1451538387262 | 188179.926264595 | 0.919026337424226 | 119.468044436218 | 0.101660271548266 | 5.01153666064e-06 | 9.70142977291842 | 0.986835744238421 | inf | 0.170978870202674 | 0.767057556984365 | 0.124324963210678 | inf | 0.763784339928386 | 0.382146811758261 | -0.67 | -0.175392670157068 | Destabilising | ARG | 0 | pnca_complex.pdb | |
| 72 | G24D | G | 24 | D | A | PZA | 10.19 | -2.197 | Destabilising | 1.138 | Stabilising | -0.5677002583979328 | 0.5103139013452914 | G24 | GA24 | 4.32448 | -20.0 | -28.0 | 0.0 | 0.0 | -28.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -10.0 | 0.0 | -6.0 | -6.0 | -6.0 | 0.0 | -9.0 | -23.0 | 0.15750697484684476 | Destabilising | -3.803 | Destabilising | -0.6484228473998295 | 0 | 0.0 | H | helix | 0.3333333333333333 | 5.96 | GLY | -0.971 | -0.799835255354201 | 9 | 9 | -1.094 | -0.914 | 9:8 | 147/150 | G:S:A | 80 | 0.8421052631578947 | 91 | effect | pnca_p.gly24asp | 0.0005030904125341 | 3.37290329402598 | 29.1630732435189 | 0.001789077082818 | 1.07995768762031 | 3.12318096596746 | 4.97876379054099 | 550.894323519243 | 29.1630847029077 | 1.46483345924118 | 29.1293325978315 | 0.0001485295621003 | 3.828187099348 | 3.53443753556636 | 1331.56873199938 | 18.6717493808583 | 1.55265977742841e-05 | -1.77 | -0.4633507853403141 | Destabilising | ASP | 0 | pnca_complex.pdb |
| 73 | G24V | G | 24 | V | A | PZA | 10.19 | -0.186 | Destabilising | -1.361 | Destabilising | -0.0480620155038759 | -0.3447315096251266 | G24 | GA24 | 2.33197 | -8.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -9.0 | 0.0 | -7.0 | -6.0 | -6.0 | 0.0 | -11.0 | -23.0 | 0.0849354234806489 | Destabilising | -2.591 | Destabilising | -0.4417732310315431 | 0 | 0.0 | H | helix | 0.3333333333333333 | 5.96 | GLY | -0.971 | -0.799835255354201 | 9 | 9 | -1.094 | -0.914 | 9:8 | 147/150 | G:S:A | 70 | 0.7368421052631579 | 85 | effect | pnca_p.gly24val | 7.18700589334483e-05 | -8.98740878149641 | 0.0001249735077034 | 0.940032862253632 | 119.46804443549 | -0.0752285585987761 | 4692673.51081173 | 2.42412778478352 | 0.384555509373631 | 0.0 | 1.0 | 0.0 | 0.0 | 188.544222231268 | 1.0341007080334399e-29 | 0.999999999999997 | -1.1 | -0.2879581151832461 | Destabilising | VAL | 0 | pnca_complex.pdb | |
| 74 | A25V | A | 25 | V | A | PZA | 12.121 | -0.514 | Destabilising | -0.995 | Destabilising | -0.1328165374677002 | -0.2520263424518744 | A25 | AA25 | -0.280715 | -2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.0 | -2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 1.0 | 0.0 | 3.0 | -1.0 | 0.0 | 0.0 | 0.0 | 3.0 | -0.053971198954087515 | Stabilising | -0.778 | Destabilising | -0.13265132139812447 | 26 | 0.2015503875968992 | H | helix | 1.0666666666666669 | 4.5 | ALA | -0.242 | -0.19934102141680396 | 6 | 6 | -0.411 | -0.147 | 7:6 | 147/150 | R:K:N:H:E:Y:D:T:S:G:A | -66 | -0.7096774193548387 | 82 | neutral | -0.65 | -0.1701570680628272 | Destabilising | VAL | 0 | pnca_complex.pdb | ||||||||||||||||||
| 75 | L27P | L | 27 | P | A | PZA | 9.548 | -1.624 | Destabilising | -1.558 | Destabilising | -0.4196382428940569 | -0.3946301925025329 | L27 | LA27 | 4.6599 | 22.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.0 | 2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -2.0 | 4.0 | -4.0 | -2.0 | 2.0 | 0.0 | 6.0 | 2.0 | 0.16972370136728854 | Destabilising | -3.919 | Destabilising | -0.6682011935208866 | 11 | 0.0547263681592039 | H | helix | 2.466666666666667 | 5.14 | LEU | -0.385 | -0.3171334431630972 | 6 | 6 | -0.553 | -0.332 | 7:6 | 147/150 | R:C:I:V:L:T:M | 71 | 0.7473684210526316 | 85 | effect | pnca_p.leu27pro | 0.0007187005893344 | 2.96819421438473 | 19.4567531291168 | 0.000173451696941 | 0.790498020917702 | 3.75484079130129 | 4.8718075812224 | 128.958907982956 | 19.4567692956558 | 1.28907072937786 | 19.4480067941443 | 2.34381123661905e-05 | 4.63007736799346 | 3.87828374077737 | 187.779865627687 | 23.6697146258566 | 1.14368245582331e-06 | -1.07 | -0.2801047120418848 | Destabilising | PRO | 0 | pnca_complex.pdb |
| 76 | L27R | L | 27 | R | A | PZA | 9.548 | -0.738 | Destabilising | -1.016 | Destabilising | -0.1906976744186046 | -0.2573454913880446 | L27 | LA27 | 2.15593 | -46.0 | -20.0 | 0.0 | -2.0 | -18.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -3.0 | 0.0 | -3.0 | -1.0 | 0.0 | 0.0 | 2.0 | 4.0 | 0.07852366348822472 | Destabilising | -3.558 | Destabilising | -0.6066496163682864 | 11 | 0.0547263681592039 | H | helix | 2.466666666666667 | 5.14 | LEU | -0.385 | -0.3171334431630972 | 6 | 6 | -0.553 | -0.332 | 7:6 | 147/150 | R:C:I:V:L:T:M | 69 | 0.7263157894736842 | 80 | effect | pnca_p.leu27arg | 0.0001437401178668 | 1.57903938912402 | 4.85029432717734 | 0.264247566376723 | 1.41439286276584 | 1.11640791656443 | 0.191756076673649 | 122.683760399218 | 4.85029436501262 | 0.685768096792206 | 4.84956447904112 | 0.312734154310187 | 0.504824686014995 | 0.061763864579114 | 379.558337204203 | 0.0881192621863332 | 0.766581879696361 | -0.1 | -0.0261780104712041 | Destabilising | ARG | 0 | pnca_complex.pdb |
| 77 | L27Q | L | 27 | Q | A | PZA | 9.548 | -1.081 | Destabilising | 0.134 | Stabilising | -0.279328165374677 | 0.0600896860986547 | L27 | LA27 | 2.24048 | -8.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -2.0 | 0.0 | -2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -10.0 | 0.0 | -6.0 | -4.0 | 2.0 | 0.0 | 2.0 | -2.0 | 0.08160315853116645 | Destabilising | -3.309 | Destabilising | -0.5641943734015346 | 11 | 0.0547263681592039 | H | helix | 2.466666666666667 | 5.14 | LEU | -0.385 | -0.3171334431630972 | 6 | 6 | -0.553 | -0.332 | 7:6 | 147/150 | R:C:I:V:L:T:M | 45 | 0.47368421052631576 | 71 | effect | -0.81 | -0.2120418848167539 | Destabilising | GLN | 0 | pnca_complex.pdb | ||||||||||||||||||
| 78 | A28T | A | 28 | T | A | PZA | 12.7 | -1.901 | Destabilising | -0.289 | Destabilising | -0.4912144702842377 | -0.0732016210739615 | A28 | AA28 | -0.611286 | -2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -2.0 | 0.0 | -2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -8.0 | 0.0 | -2.0 | -6.0 | -8.0 | 0.0 | -4.0 | -5.0 | -0.117527878181958 | Stabilising | -2.577 | Destabilising | -0.439386189258312 | 0 | 0.0 | H | helix | 0.3666666666666666 | 6.48 | ALA | -0.564 | -0.4645799011532125 | 7 | 7 | -0.728 | -0.485 | 8:7 | 147/150 | P:A:I:V:L | 41 | 0.43157894736842106 | 71 | effect | -1.74 | -0.4554973821989529 | Destabilising | THR | 0 | pnca_complex.pdb | ||||||||||||||||||
| 79 | A28D | A | 28 | D | A | PZA | 12.7 | -2.8 | Destabilising | 0.5539999999999999 | Stabilising | -0.7235142118863048 | 0.2484304932735425 | A28 | AA28 | 3.01687 | -8.0 | -52.0 | 0.0 | 0.0 | -52.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 4.0 | -4.0 | 0.0 | 0.0 | 0.0 | 0.0 | -7.0 | 0.0 | -3.0 | -2.0 | -8.0 | 0.0 | -10.0 | -5.0 | 0.10988097232643011 | Destabilising | -4.44 | Destabilising | -0.7570332480818415 | 0 | 0.0 | H | helix | 0.3666666666666666 | 6.48 | ALA | -0.564 | -0.4645799011532125 | 7 | 7 | -0.728 | -0.485 | 8:7 | 147/150 | P:A:I:V:L | 67 | 0.7052631578947368 | 80 | effect | pnca_p.ala28asp | 7.18700589334483e-05 | 12.1451538387266 | 188179.926264663 | 0.91902633742424 | 119.468044436242 | 0.101660271548249 | 5.01153666061778e-06 | 9.70142977291842 | 0.986835744238421 | inf | 0.170978870202674 | 0.767057556984365 | 0.124324963210678 | inf | 0.763784339928386 | 0.382146811758261 | -1.38 | -0.3612565445026178 | Destabilising | ASP | 0 | pnca_complex.pdb | |
| 80 | A30V | A | 30 | V | A | PZA | 16.46 | -0.401 | Destabilising | -0.846 | Destabilising | -0.1036175710594315 | -0.2142857142857142 | A30 | AA30 | -0.154342 | -4.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -5.0 | 0.0 | -5.0 | -4.0 | 0.0 | 0.0 | 0.0 | -3.0 | -0.02967430592940091 | Stabilising | -0.442 | Destabilising | -0.07536231884057971 | 37 | 0.2868217054263566 | H | helix | 0.6 | 3.88 | ALA | 1.207 | 0.3868589743589744 | 1 | 1 | 0.59 | 1.183 | 3:1 | 147/150 | Q:E:Y:K:I:R:V:L:N:P:M:A:G:T:D | -76 | -0.8172043010752689 | 87 | neutral | pnca_p.ala30val | 7.18700589334483e-05 | 12.1451538387263 | 188179.9262646 | 0.919026337424228 | 119.468044436221 | 0.101660271548264 | 5.01153666063734e-06 | 9.70142977291842 | 0.986835744238421 | inf | 0.170978870202674 | 0.767057556984365 | 0.124324963210678 | inf | 0.763784339928386 | 0.382146811758261 | -0.7 | -0.1832460732984293 | Destabilising | VAL | 0 | pnca_complex.pdb | |
| 81 | I31T | I | 31 | T | A | PZA | 11.654000000000002 | -3.12 | Destabilising | -0.358 | Destabilising | -0.8062015503875969 | -0.0906788247213779 | I31 | IA31 | 3.06922 | 24.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -2.0 | 0.0 | -2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -5.0 | 0.0 | -5.0 | 0.0 | 2.0 | 0.0 | 2.0 | 0.0 | 0.11178767327850582 | Destabilising | -3.102 | Destabilising | -0.5289002557544756 | 0 | 0.0 | H | helix | 1.8333333333333333 | 6.99 | ILE | -0.562 | -0.4629324546952225 | 7 | 7 | -0.728 | -0.485 | 8:7 | 147/150 | I:L:V:T:A | 62 | 0.6526315789473685 | 80 | effect | pnca_p.ile31thr | 7.18700589334483e-05 | -8.98740878149641 | 0.0001249735077034 | 0.940032862253633 | 119.46804443549 | -0.0752285585987758 | 4692673.51081066 | 2.42412778478352 | 0.384555509373631 | 0.0 | 1.0 | 0.0 | 0.0 | 188.544222231268 | 1.0341007080334399e-29 | 0.999999999999997 | -3.05 | -0.7984293193717278 | Destabilising | THR | 0 | pnca_complex.pdb | |
| 82 | I31S | I | 31 | S | A | PZA | 11.654000000000002 | -3.608 | Destabilising | -0.3289999999999999 | Destabilising | -0.9322997416020672 | -0.0833333333333333 | I31 | IA31 | 4.81248 | 28.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.0 | 0.0 | 2.0 | 2.0 | 0.1752809970935103 | Destabilising | -3.395 | Destabilising | -0.5788576300085251 | 0 | 0.0 | H | helix | 1.8333333333333333 | 6.99 | ILE | -0.562 | -0.4629324546952225 | 7 | 7 | -0.728 | -0.485 | 8:7 | 147/150 | I:L:V:T:A | 60 | 0.631578947368421 | 80 | effect | pnca_p.ile31ser | 0.0004312203536006 | 14.1472939191279 | 1393450.94022095 | 0.915018435774967 | 132.576060676205 | 0.106710773023195 | 4.17896182050295 | 58.3312262958281 | 1.7659011066874 | inf | 2.48532104922106e-05 | 4.60461750194108 | 5.71767556863798 | inf | 23.547488635408 | 1.21868387173808e-06 | -3.34 | -0.8743455497382199 | Destabilising | SER | 0 | pnca_complex.pdb | |
| 83 | S32I | S | 32 | I | A | PZA | 16.787 | 0.018 | Stabilising | -1.207 | Destabilising | 0.0153061224489795 | -0.3057244174265451 | S32 | SA32 | 0.86851 | -10.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.0 | 0.0 | 4.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -2.0 | -3.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.031633024716089135 | Destabilising | -0.677 | Destabilising | -0.1154305200341006 | 7 | 0.0451612903225806 | T | loop | 0.0666666666666666 | 4.62 | SER | -0.647 | -0.5329489291598023 | 7 | 7 | -0.779 | -0.553 | 8:7 | 147/150 | D:T:S:G:A:V:N:R:Q | 29 | 0.30526315789473685 | 63 | effect | pnca_p.ser32ile | 7.18700589334483e-05 | 12.1451538387266 | 188179.926264664 | 0.919026337424239 | 119.468044436241 | 0.101660271548249 | 5.01153666061844e-06 | 9.70142977291842 | 0.986835744238421 | inf | 0.170978870202674 | 0.767057556984365 | 0.124324963210678 | inf | 0.763784339928386 | 0.382146811758261 | -0.41 | -0.1073298429319371 | Destabilising | ILE | 0 | pnca_complex.pdb | |
| 84 | S32G | S | 32 | G | A | PZA | 16.787 | -0.875 | Destabilising | -1.334 | Destabilising | -0.2260981912144702 | -0.3378926038500506 | S32 | SA32 | 0.0485615999999999 | 4.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.0 | 0.0 | 4.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 3.0 | 0.0 | 3.0 | 0.0 | 2.0 | 0.0 | 5.0 | 17.0 | 0.0017687191777329345 | Destabilising | -0.992 | Destabilising | -0.1691389599317988 | 7 | 0.0451612903225806 | T | loop | 0.0666666666666666 | 4.62 | SER | -0.647 | -0.5329489291598023 | 7 | 7 | -0.779 | -0.553 | 8:7 | 147/150 | D:T:S:G:A:V:N:R:Q | -32 | -0.34408602150537637 | 66 | neutral | -0.43 | -0.112565445026178 | Destabilising | GLY | 0 | pnca_complex.pdb | ||||||||||||||||||
| 85 | D33V | D | 33 | V | A | PZA | 20.313 | 0.276 | Stabilising | -0.795 | Destabilising | 0.2346938775510204 | -0.2013677811550152 | D33 | DA33 | 1.48114 | 4.0 | 14.0 | 0.0 | 2.0 | 12.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -2.0 | 0.05394634284923404 | Destabilising | -0.022 | Destabilising | -0.0037510656436487637 | 77 | 0.3989637305699481 | T | loop | -1.8666666666666665 | 3.72 | ASP | 1.213 | 0.3887820512820513 | 1 | 1 | 0.842 | 1.183 | 2:1 | 147/150 | N:L:V:K:R:H:E:Q:D:T:A:S:G | -5 | -0.053763440860215055 | 53 | neutral | pnca_p.asp33val | 7.18700589334483e-05 | 12.1451538387263 | 188179.9262646 | 0.919026337424228 | 119.468044436221 | 0.101660271548264 | 5.01153666063734e-06 | 9.70142977291842 | 0.986835744238421 | inf | 0.170978870202674 | 0.767057556984365 | 0.124324963210678 | inf | 0.763784339928386 | 0.382146811758261 | -0.3 | -0.0785340314136125 | Destabilising | VAL | 0 | pnca_complex.pdb | |
| 86 | Y34C | Y | 34 | C | A | PZA | 18.259 | -1.829 | Destabilising | -0.635 | Destabilising | -0.472609819121447 | -0.1608409321175278 | Y34 | YA34 | 1.92562 | 48.0 | 10.0 | 0.0 | 2.0 | 8.0 | 0.0 | 0.0 | 0.0 | 0.0 | -2.0 | 0.0 | -4.0 | 2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.0 | 0.0 | 0.0 | 2.0 | 6.0 | 0.0 | 2.0 | 6.0 | 0.07013527196439369 | Destabilising | -0.861 | Destabilising | -0.14680306905370843 | 26 | 0.0988593155893536 | T | loop | -0.3333333333333334 | 4.65 | TYR | 0.42 | 0.1346153846153846 | 3 | 3 | 0.083 | 0.59 | 5:3 | 147/150 | M:A:W:Y:E:F:H:Q:V:L:R:C:I | -2 | -0.021505376344086023 | 53 | neutral | -1.94 | -0.5078534031413613 | Destabilising | CYS | 0 | pnca_complex.pdb | ||||||||||||||||||
| 87 | Y34D | Y | 34 | D | A | PZA | 18.259 | -1.857 | Destabilising | 0.124 | Stabilising | -0.47984496124031 | 0.0556053811659192 | Y34 | YA34 | 2.0881 | 38.0 | -18.0 | 0.0 | 0.0 | -18.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.0 | 0.0 | 0.0 | 2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 3.0 | 0.0 | 0.0 | 3.0 | 8.0 | 0.0 | 2.0 | 6.0 | 0.07605314724029166 | Destabilising | -1.484 | Destabilising | -0.2530264279624893 | 26 | 0.0988593155893536 | T | loop | -0.3333333333333334 | 4.65 | TYR | 0.42 | 0.1346153846153846 | 3 | 3 | 0.083 | 0.59 | 5:3 | 147/150 | M:A:W:Y:E:F:H:Q:V:L:R:C:I | 30 | 0.3157894736842105 | 66 | effect | pnca_p.tyr34asp | 0.0005749604714675 | 2.6796663501904 | 14.5802277940117 | 0.0010245352377104 | 0.816050632122416 | 3.28370108999367 | 3.35697961122125 | 99.553869259241 | 14.5802781289507 | 1.16376580853041 | 14.5801759034061 | 0.0005075351447614 | 3.29453387923245 | 2.60435121163486 | 147.676327006136 | 15.0663448164144 | 0.0001037975122989 | -1.99 | -0.5209424083769634 | Destabilising | ASP | 0 | pnca_complex.pdb |
| 88 | Y34S | Y | 34 | S | A | PZA | 18.259 | -3.224 | Destabilising | -0.316 | Destabilising | -0.8330749354005167 | -0.0800405268490375 | Y34 | YA34 | 0.32836 | 48.0 | 10.0 | 0.0 | 2.0 | 8.0 | 0.0 | 0.0 | 0.0 | 0.0 | -2.0 | 0.0 | -4.0 | 2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.0 | 0.0 | 0.0 | 2.0 | 10.0 | 0.0 | 2.0 | 10.0 | 0.011959585952694876 | Destabilising | -1.692 | Destabilising | -0.28849104859335034 | 26 | 0.0988593155893536 | T | loop | -0.3333333333333334 | 4.65 | TYR | 0.42 | 0.1346153846153846 | 3 | 3 | 0.083 | 0.59 | 5:3 | 147/150 | M:A:W:Y:E:F:H:Q:V:L:R:C:I | 13 | 0.1368421052631579 | 59 | effect | pnca_p.tyr34ser | 0.0001437401178668 | -9.98752126245062 | 4.5970013133425e-05 | 0.942832958100734 | 139.277183325398 | -0.071709672926946 | 144471.706314878 | 1.2119588062211 | 0.0834878586628579 | 0.0 | 1.0 | 0.0 | 0.0 | 25.8386585962163 | 1.0105682238915901e-25 | 0.999999999999746 | -3.31 | -0.8664921465968587 | Destabilising | SER | 0 | pnca_complex.pdb | |
| 89 | L35R | L | 35 | R | A | PZA | 17.42 | -1.493 | Destabilising | -0.653 | Destabilising | -0.3857881136950905 | -0.1654002026342452 | L35 | LA35 | -2.11958 | -30.0 | -32.0 | 0.0 | -2.0 | -30.0 | 0.0 | 0.0 | 0.0 | 0.0 | -2.0 | 0.0 | -2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -6.0 | 0.0 | -6.0 | -2.0 | -2.0 | 0.0 | -8.0 | -2.0 | -0.4075174959624702 | Stabilising | -2.016 | Destabilising | -0.34373401534526854 | 35 | 0.1741293532338308 | T | loop | 1.4333333333333331 | 4.69 | LEU | 0.183 | 0.058653846153846154 | 4 | 4 | -0.038 | 0.389 | 5:4 | 147/150 | G:A:S:M:T:Q:V:L:I | 64 | 0.6736842105263158 | 80 | effect | pnca_p.leu35arg | 0.0025873221216041 | -1.25661854335884 | 0.28461481380629 | 0.0842996990557667 | 0.727940577686249 | -1.72626527752167 | 0.0461651045270816 | 0.934717733973448 | 0.284614813531639 | -0.545742499657136 | 0.284630509244736 | 0.0746087863378038 | 1.1272100246275 | 0.033101827382896 | 1.11162498496942 | 2.62510215004498 | 0.105185735611338 | -0.88 | -0.2303664921465968 | Destabilising | ARG | 0 | pnca_complex.pdb |
| 90 | L35P | L | 35 | P | A | PZA | 17.42 | -2.0540000000000003 | Destabilising | -0.954 | Destabilising | -0.530749354005168 | -0.2416413373860182 | L35 | LA35 | 8.91998 | 24.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.0 | -5.0 | 1.0 | 8.0 | 0.0 | 0.0 | 8.0 | 0.3248850880324012 | Destabilising | -2.108 | Destabilising | -0.35942028985507246 | 35 | 0.1741293532338308 | T | loop | 1.4333333333333331 | 4.69 | LEU | 0.183 | 0.058653846153846154 | 4 | 4 | -0.038 | 0.389 | 5:4 | 147/150 | G:A:S:M:T:Q:V:L:I | 82 | 0.8631578947368421 | 91 | effect | pnca_p.leu35pro | 0.0005749604714675 | 1.58004161593687 | 4.85515785897614 | 0.0255237229775361 | 0.70746570614631 | 2.23338262506551 | 1.14726850666833 | 20.5466864308597 | 4.85515789473684 | 0.686203358177678 | 4.85442845338892 | 0.033386534669467 | 1.47642865587913 | 0.903495684237988 | 26.0627135254866 | 4.01139112494925 | 0.0451938468216249 | -1.48 | -0.387434554973822 | Destabilising | PRO | 0 | pnca_complex.pdb |
| 91 | L35M | L | 35 | M | A | PZA | 17.42 | -1.162 | Destabilising | -1.12 | Destabilising | -0.3002583979328165 | -0.2836879432624113 | L35 | LA35 | -0.61263 | -10.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -1.0 | 0.0 | 2.0 | 0.0 | -2.0 | 2.0 | -0.11778628008921019 | Stabilising | -0.928 | Destabilising | -0.15822676896845694 | 35 | 0.1741293532338308 | T | loop | 1.4333333333333331 | 4.69 | LEU | 0.183 | 0.058653846153846154 | 4 | 4 | -0.038 | 0.389 | 5:4 | 147/150 | G:A:S:M:T:Q:V:L:I | -4 | -0.043010752688172046 | 53 | neutral | -0.38 | -0.0994764397905759 | Destabilising | MET | 0 | pnca_complex.pdb | ||||||||||||||||||
| 92 | E37V | E | 37 | V | A | PZA | 24.08 | -0.033 | Destabilising | -0.519 | Destabilising | -0.0085271317829457 | -0.1314589665653495 | E37 | EA37 | 0.085964 | 12.0 | 18.0 | 0.0 | 2.0 | 16.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.0 | 0.0 | 2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -1.0 | 0.0 | -2.0 | 1.0 | 2.0 | 0.0 | 2.0 | -2.0 | 0.0031309960008449943 | Destabilising | -0.065 | Destabilising | -0.011082693947144074 | 138 | 0.6188340807174888 | S | loop | 0.0333333333333333 | 3.58 | GLU | 2.736 | 0.8769230769230769 | 1 | 1 | 1.183 | 3.125 | 1:1 | 95/150 | F:E:Q:V:N:L:I:R:T:W:H:Y:M:G:A:S:P:D | -32 | -0.34408602150537637 | 66 | neutral | pnca_p.glu37val | 7.18700589334483e-05 | -8.9874087814964 | 0.0001249735077034 | 0.940032862253632 | 119.468044435489 | -0.0752285585987761 | 4692673.51081157 | 2.42412778478352 | 0.384555509373631 | 0.0 | 1.0 | 0.0 | 0.0 | 188.544222231268 | 1.0341007080334399e-29 | 0.999999999999997 | -0.26 | -0.0680628272251308 | Destabilising | VAL | 0 | pnca_complex.pdb | |
| 93 | Y41D | Y | 41 | D | A | PZA | 19.063 | -2.11 | Destabilising | -0.298 | Destabilising | -0.545219638242894 | -0.0754812563323201 | Y41 | YA41 | 5.35024 | 36.0 | -28.0 | 0.0 | -4.0 | -24.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -2.0 | 2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.0 | 0.0 | -2.0 | 4.0 | 4.0 | 0.0 | 0.0 | 4.0 | 0.194867386854508 | Destabilising | -3.198 | Destabilising | -0.5452685421994885 | 35 | 0.1330798479087452 | - | loop | -2.6666666666666665 | 4.97 | TYR | -0.477 | -0.3929159802306425 | 7 | 7 | -0.674 | -0.411 | 7:7 | 147/150 | L:N:R:F:H:Y:W:A:G | 70 | 0.7368421052631579 | 85 | effect | pnca_p.tyr41asp | 7.18700589334483e-05 | 12.1451538387252 | 188179.926264407 | 0.919026337424193 | 119.468044436159 | 0.101660271548308 | 5.01153666069528e-06 | 9.70142977291842 | 0.986835744238421 | inf | 0.170978870202674 | 0.767057556984365 | 0.124324963210678 | inf | 0.763784339928386 | 0.382146811758261 | -1.85 | -0.4842931937172775 | Destabilising | ASP | 0 | pnca_complex.pdb | |
| 94 | Y41C | Y | 41 | C | A | PZA | 19.063 | -1.057 | Destabilising | -1.07 | Destabilising | -0.2731266149870801 | -0.2710233029381966 | Y41 | YA41 | 4.03027 | 46.0 | 8.0 | 0.0 | 0.0 | 8.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.0 | 0.0 | -2.0 | 4.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.0 | 0.0 | -2.0 | 4.0 | 10.0 | 0.0 | 2.0 | 10.0 | 0.1467912062296491 | Destabilising | -1.836 | Destabilising | -0.3130434782608696 | 35 | 0.1330798479087452 | - | loop | -2.6666666666666665 | 4.97 | TYR | -0.477 | -0.3929159802306425 | 7 | 7 | -0.674 | -0.411 | 7:7 | 147/150 | L:N:R:F:H:Y:W:A:G | 37 | 0.3894736842105263 | 66 | effect | pnca_p.tyr41cys | 7.18700589334483e-05 | -8.98740878149643 | 0.0001249735077034 | 0.940032862253634 | 119.468044435493 | -0.0752285585987739 | 4692673.51081287 | 2.42412778478352 | 0.384555509373631 | 0.0 | 1.0 | 0.0 | 0.0 | 188.544222231268 | 1.0341007080334399e-29 | 0.999999999999997 | 0.19 | 0.1067415730337078 | Stabilising | CYS | 0 | pnca_complex.pdb | |
| 95 | H43D | H | 43 | D | A | PZA | 19.543 | -1.596 | Destabilising | -0.912 | Destabilising | -0.4124031007751937 | -0.2310030395136778 | H43 | HA43 | 3.54222 | 6.0 | -24.0 | 0.0 | -2.0 | -22.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -2.0 | 0.0 | -2.0 | -6.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.1290153628741468 | Destabilising | -0.971 | Destabilising | -0.16555839727195226 | 40 | 0.1785714285714285 | E | strand | -0.7333333333333334 | 4.75 | HIS | 1.071 | 0.3432692307692307 | 1 | 1 | 0.59 | 1.183 | 3:1 | 147/150 | Y:F:H:Q:L:N:V:R:I:C:A:M:T:P:D | 27 | 0.28421052631578947 | 63 | effect | pnca_p.his43asp | 7.18700589334483e-05 | -8.98740878149641 | 0.0001249735077034 | 0.940032862253634 | 119.468044435492 | -0.0752285585987746 | 4692673.51081392 | 2.42412778478352 | 0.384555509373631 | 0.0 | 1.0 | 0.0 | 0.0 | 188.544222231268 | 1.0341007080334399e-29 | 0.999999999999997 | -1.78 | -0.4659685863874346 | Destabilising | ASP | 0 | pnca_complex.pdb | |
| 96 | H43Y | H | 43 | Y | A | PZA | 19.543 | 0.984 | Stabilising | -1.341 | Destabilising | 0.8367346938775512 | -0.3396656534954407 | H43 | HA43 | -0.653353 | -22.0 | -6.0 | 0.0 | -2.0 | -4.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -2.0 | 2.0 | 0.0 | 0.0 | 0.0 | 0.0 | -1.0 | 0.0 | -2.0 | 0.0 | 4.0 | 0.0 | -2.0 | 2.0 | -0.12561581942628625 | Stabilising | -0.455 | Destabilising | -0.07757885763000852 | 40 | 0.1785714285714285 | E | strand | -0.7333333333333334 | 4.75 | HIS | 1.071 | 0.3432692307692307 | 1 | 1 | 0.59 | 1.183 | 3:1 | 147/150 | Y:F:H:Q:L:N:V:R:I:C:A:M:T:P:D | -33 | -0.3548387096774194 | 66 | neutral | 1.37 | 0.7696629213483147 | Stabilising | TYR | 0 | pnca_complex.pdb | ||||||||||||||||||
| 97 | H43P | H | 43 | P | A | PZA | 19.543 | -0.892 | Destabilising | -1.878 | Destabilising | -0.2304909560723514 | -0.4756838905775076 | H43 | HA43 | 2.10447 | 18.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.0 | 0.0 | 0.0 | 2.0 | 0.0 | 0.0 | 0.0 | 0.0 | -4.0 | 2.0 | -3.0 | -4.0 | 4.0 | 0.0 | 4.0 | -4.0 | 0.07664937827344313 | Destabilising | -1.154 | Destabilising | -0.19676044330775785 | 40 | 0.1785714285714285 | E | strand | -0.7333333333333334 | 4.75 | HIS | 1.071 | 0.3432692307692307 | 1 | 1 | 0.59 | 1.183 | 3:1 | 147/150 | Y:F:H:Q:L:N:V:R:I:C:A:M:T:P:D | 30 | 0.3157894736842105 | 66 | effect | 0.4 | 0.2247191011235955 | Stabilising | PRO | 0 | pnca_complex.pdb | ||||||||||||||||||
| 98 | V44A | V | 44 | A | A | PZA | 17.073 | -2.343 | Destabilising | -1.246 | Destabilising | -0.6054263565891472 | -0.3156028368794326 | V44 | VA44 | 3.40395 | 2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.0 | 1.0 | 0.12397926849700246 | Destabilising | -1.839 | Destabilising | -0.3135549872122762 | 13 | 0.0747126436781609 | E | strand | 1.7333333333333334 | 5.57 | VAL | -0.194 | -0.1598023064250412 | 6 | 6 | -0.411 | -0.038 | 7:5 | 149/150 | T:A:Q:C:R:I:L:V | 57 | 0.6 | 75 | effect | pnca_p.val44ala | 7.18700589334483e-05 | 12.1451538387265 | 188179.926264644 | 0.919026337424235 | 119.468044436235 | 0.101660271548254 | 5.01153666062486e-06 | 9.70142977291842 | 0.986835744238421 | inf | 0.170978870202674 | 0.767057556984365 | 0.124324963210678 | inf | 0.763784339928386 | 0.382146811758261 | -2.01 | -0.5261780104712042 | Destabilising | ALA | 0 | pnca_complex.pdb | |
| 99 | V44G | V | 44 | G | A | PZA | 17.073 | -2.975 | Destabilising | -1.136 | Destabilising | -0.7687338501291989 | -0.2877406281661601 | V44 | VA44 | 5.19527 | 8.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -2.0 | 0.0 | -2.0 | 0.0 | 4.0 | 0.0 | 5.0 | 19.0 | 0.1892230421258896 | Destabilising | -3.88 | Destabilising | -0.6615515771526002 | 13 | 0.0747126436781609 | E | strand | 1.7333333333333334 | 5.57 | VAL | -0.194 | -0.1598023064250412 | 6 | 6 | -0.411 | -0.038 | 7:5 | 149/150 | T:A:Q:C:R:I:L:V | 74 | 0.7789473684210526 | 85 | effect | pnca_p.val44gly | 0.0005030904125341 | 2.4969239337312 | 12.1450773794064 | 0.0028293218857323 | 0.83629495944555 | 2.98569769616526 | 2.61610833082893 | 84.8371270838078 | 12.1451137320977 | 1.08440158608155 | 12.1416664151504 | 0.0022516005975125 | 2.64750864476206 | 1.98635523014012 | 127.719946645636 | 11.0019205274607 | 0.0009101752788745 | -2.43 | -0.6361256544502618 | Destabilising | GLY | 0 | pnca_complex.pdb |
| 100 | V45E | V | 45 | E | A | PZA | 13.521 | -3.389 | Destabilising | -1.5930000000000002 | Destabilising | -0.8757105943152454 | -0.4034954407294833 | V45 | VA45 | 4.7083900000000005 | -32.0 | -34.0 | 0.0 | -2.0 | -32.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.0 | 0.0 | 2.0 | -1.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.17148981271716726 | Destabilising | -4.817 | Destabilising | -0.8213128729752771 | 0 | 0.0 | E | strand | 3.4 | 8.66 | VAL | -0.375 | -0.3088962108731466 | 6 | 6 | -0.553 | -0.244 | 7:6 | 149/150 | F:A:Y:M:I:V:L | 80 | 0.8421052631578947 | 91 | effect | -1.92 | -0.5026178010471204 | Destabilising | GLU | 0 | pnca_complex.pdb | ||||||||||||||||||
| 101 | V45G | V | 45 | G | A | PZA | 13.521 | -3.523 | Destabilising | -1.938 | Destabilising | -0.9103359173126616 | -0.4908814589665654 | V45 | VA45 | 5.16465 | 10.0 | 2.0 | 0.0 | 0.0 | 2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 4.0 | 0.0 | 2.0 | 1.0 | 4.0 | 0.0 | 5.0 | 25.0 | 0.1881077950742648 | Destabilising | -3.509 | Destabilising | -0.5982949701619777 | 0 | 0.0 | E | strand | 3.4 | 8.66 | VAL | -0.375 | -0.3088962108731466 | 6 | 6 | -0.553 | -0.244 | 7:6 | 149/150 | F:A:Y:M:I:V:L | 80 | 0.8421052631578947 | 91 | effect | pnca_p.val45gly | 7.18700589334483e-05 | -8.98740878149642 | 0.0001249735077034 | 0.940032862253634 | 119.468044435493 | -0.0752285585987741 | 4692673.51081481 | 2.42412778478352 | 0.384555509373631 | 0.0 | 1.0 | 0.0 | 0.0 | 188.544222231268 | 1.0341007080334399e-29 | 0.999999999999997 | -3.55 | -0.9293193717277488 | Destabilising | GLY | 0 | pnca_complex.pdb | |
| 102 | V45A | V | 45 | A | A | PZA | 13.521 | -2.783 | Destabilising | -2.228 | Destabilising | -0.7191214470284237 | -0.5643363728470112 | V45 | VA45 | 3.60576 | 6.0 | 2.0 | 0.0 | 0.0 | 2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.0 | 0.0 | 0.0 | 1.0 | 2.0 | 0.0 | 0.0 | 7.0 | 0.13132962798388684 | Destabilising | -1.973 | Destabilising | -0.3364023870417732 | 0 | 0.0 | E | strand | 3.4 | 8.66 | VAL | -0.375 | -0.3088962108731466 | 6 | 6 | -0.553 | -0.244 | 7:6 | 149/150 | F:A:Y:M:I:V:L | 39 | 0.4105263157894737 | 66 | effect | pnca_p.val45ala | 7.18700589334483e-05 | -8.98740878149641 | 0.0001249735077034 | 0.940032862253633 | 119.46804443549 | -0.0752285585987758 | 4692673.5108122 | 2.42412778478352 | 0.384555509373631 | 0.0 | 1.0 | 0.0 | 0.0 | 188.544222231268 | 1.0341007080334399e-29 | 0.999999999999997 | -2.23 | -0.5837696335078534 | Destabilising | ALA | 0 | pnca_complex.pdb | |
| 103 | A46E | A | 46 | E | A | PZA | 11.322 | -1.747 | Destabilising | -1.749 | Destabilising | -0.4514211886304909 | -0.4430091185410335 | A46 | AA46 | 2.18089 | -36.0 | -32.0 | 0.0 | 0.0 | -32.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -4.0 | 0.0 | 1.0 | -5.0 | -8.0 | 0.0 | -8.0 | -7.0 | 0.07943276101952958 | Destabilising | -5.096 | Destabilising | -0.8688832054560954 | 0 | 0.0 | E | strand | 1.7666666666666666 | 8.13 | ALA | -0.822 | -0.6771004942339374 | 8 | 8 | -0.914 | -0.779 | 8:8 | 149/150 | Q:F:Y:I:V:L:T:A:S:G | 79 | 0.8315789473684211 | 85 | effect | pnca_p.ala46glu | 7.18700589334483e-05 | 12.1451538387253 | 188179.926264417 | 0.919026337424195 | 119.468044436163 | 0.101660271548305 | 5.01153666069207e-06 | 9.70142977291842 | 0.986835744238421 | inf | 0.170978870202674 | 0.767057556984365 | 0.124324963210678 | inf | 0.763784339928386 | 0.382146811758261 | -1.21 | -0.3167539267015707 | Destabilising | GLU | 0 | pnca_complex.pdb | |
| 104 | A46V | A | 46 | V | A | PZA | 11.322 | 1.017 | Stabilising | -2.718 | Destabilising | 0.8647959183673471 | -0.6884498480243161 | A46 | AA46 | -2.38862 | -2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -7.0 | 0.0 | 1.0 | -8.0 | -2.0 | 0.0 | 2.0 | -7.0 | -0.4592440206106283 | Stabilising | -1.487 | Destabilising | -0.253537936913896 | 0 | 0.0 | E | strand | 1.7666666666666666 | 8.13 | ALA | -0.822 | -0.6771004942339374 | 8 | 8 | -0.914 | -0.779 | 8:8 | 149/150 | Q:F:Y:I:V:L:T:A:S:G | 59 | 0.6210526315789474 | 75 | effect | pnca_p.ala46val | 0.0004312203536006 | 2.27336112535402 | 9.7119892297561 | 0.0086576033028962 | 0.865947753893075 | 2.62528670480821 | 1.89450831676925 | 70.0912742677304 | 9.712 | 0.987308673731182 | 9.70929820233251 | 0.0095462527031996 | 2.02016707341074 | 1.39065774214338 | 107.435987551185 | 7.20065367726982 | 0.0072877030810549 | 0.44 | 0.247191011235955 | Stabilising | VAL | 0 | pnca_complex.pdb |
| 105 | A46P | A | 46 | P | A | PZA | 11.322 | -0.221 | Destabilising | -2.408 | Destabilising | -0.0571059431524547 | -0.6099290780141844 | A46 | AA46 | 2.09234 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.0 | 2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -10.0 | 0.0 | -8.0 | -4.0 | -2.0 | 0.0 | 0.0 | -3.0 | 0.07620757726964794 | Destabilising | -4.42 | Destabilising | -0.753623188405797 | 0 | 0.0 | E | strand | 1.7666666666666666 | 8.13 | ALA | -0.822 | -0.6771004942339374 | 8 | 8 | -0.914 | -0.779 | 8:8 | 149/150 | Q:F:Y:I:V:L:T:A:S:G | 81 | 0.8526315789473684 | 91 | effect | pnca_p.ala46pro | 0.0001437401178668 | 13.1456002256206 | 511754.463552641 | 0.924803768447002 | 139.277183326574 | 0.0943844491369209 | 0.0001628371344451 | 19.411022297013 | 1.28804840845689 | inf | 0.0292235860951597 | 1.53426649183163 | 0.91081598550184 | inf | 4.73122070382274 | 0.0296198560706035 | 0.65 | 0.3651685393258427 | Stabilising | PRO | 0 | pnca_complex.pdb | |
| 106 | A46T | A | 46 | T | A | PZA | 11.322 | -1.192 | Destabilising | -1.355 | Destabilising | -0.3080103359173126 | -0.3432117527862208 | A46 | AA46 | -1.34478 | -2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -2.0 | 0.0 | -2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -9.0 | 0.0 | -2.0 | -7.0 | -2.0 | 0.0 | -2.0 | -3.0 | -0.2585518726447743 | Stabilising | -2.283 | Destabilising | -0.38925831202046035 | 0 | 0.0 | E | strand | 1.7666666666666666 | 8.13 | ALA | -0.822 | -0.6771004942339374 | 8 | 8 | -0.914 | -0.779 | 8:8 | 149/150 | Q:F:Y:I:V:L:T:A:S:G | -6 | -0.06451612903225806 | 53 | neutral | pnca_p.ala46thr | 0.0001437401178668 | 1.57903938912402 | 4.85029432717733 | 0.264247566376724 | 1.41439286276584 | 1.11640791656443 | 0.191756076673846 | 122.683760398934 | 4.85029436501262 | 0.685768096792206 | 4.84956447904112 | 0.312734154310187 | 0.504824686014995 | 0.061763864579114 | 379.558337204203 | 0.0881192621863332 | 0.766581879696361 | -0.62 | -0.1623036649214659 | Destabilising | THR | 0 | pnca_complex.pdb |
| 107 | T47N | T | 47 | N | A | PZA | 7.502999999999999 | -1.831 | Destabilising | -0.208 | Destabilising | -0.4731266149870801 | -0.0526849037487335 | T47 | TA47 | 0.956982 | -26.0 | 2.0 | 0.0 | 0.0 | 2.0 | 0.0 | 0.0 | 0.0 | 0.0 | -4.0 | 0.0 | -2.0 | 2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 1.0 | -1.0 | -4.0 | 0.0 | -6.0 | 2.0 | 0.034855367536185435 | Destabilising | -5.182 | Destabilising | -0.8835464620630862 | 0 | 0.0 | E | strand | -0.9333333333333332 | 10.3 | THR | -0.925 | -0.7619439868204284 | 8 | 8 | -1.028 | -0.872 | 9:8 | 149/150 | C:K:I:T:S | 77 | 0.8105263157894737 | 85 | effect | pnca_p.thr47asn | 7.18700589334483e-05 | -8.98740878149641 | 0.0001249735077034 | 0.940032862253634 | 119.468044435492 | -0.0752285585987742 | 4692673.51081218 | 2.42412778478352 | 0.384555509373631 | 0.0 | 1.0 | 0.0 | 0.0 | 188.544222231268 | 1.0341007080334399e-29 | 0.999999999999997 | -1.29 | -0.3376963350785341 | Destabilising | ASN | 0 | pnca_complex.pdb | |
| 108 | T47I | T | 47 | I | A | PZA | 7.502999999999999 | -0.155 | Destabilising | -2.112 | Destabilising | -0.0400516795865633 | -0.5349544072948329 | T47 | TA47 | -1.0395 | -32.0 | 2.0 | 0.0 | 0.0 | 2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.0 | 0.0 | 0.0 | 0.0 | 0.0 | -2.0 | 0.0 | -3.0 | -1.0 | 2.0 | 0.0 | 0.0 | 4.0 | -0.19985772514035224 | Stabilising | -1.52 | Destabilising | -0.2591645353793691 | 0 | 0.0 | E | strand | -0.9333333333333332 | 10.3 | THR | -0.925 | -0.7619439868204284 | 8 | 8 | -1.028 | -0.872 | 9:8 | 149/150 | C:K:I:T:S | 72 | 0.7578947368421053 | 85 | effect | pnca_p.thr47ile | 0.0003593502946672 | 0.192485717774877 | 1.21225918982515 | 0.863268405978747 | 1.11770505415734 | 0.172215126932566 | 0.061955084955231 | 8.19905671742341 | 1.21225820016821 | 0.083595130527928 | 1.212214074125 | 1.0 | 0.0 | 0.0246053772172713 | 12.260612593354 | 7.1929763849897505e-25 | 0.999999999999323 | -0.62 | -0.1623036649214659 | Destabilising | ILE | 0 | pnca_complex.pdb |
| 109 | T47P | T | 47 | P | A | PZA | 7.502999999999999 | -1.493 | Destabilising | -1.892 | Destabilising | -0.3857881136950905 | -0.4792299898682877 | T47 | TA47 | 1.93613 | 4.0 | 2.0 | 0.0 | 0.0 | 2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.0 | 2.0 | 0.0 | 2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 4.0 | 0.0 | 2.0 | 2.0 | 8.0 | 0.0 | 6.0 | 0.0 | 0.07051806904187821 | Destabilising | -5.056 | Destabilising | -0.8620630861040068 | 0 | 0.0 | E | strand | -0.9333333333333332 | 10.3 | THR | -0.925 | -0.7619439868204284 | 8 | 8 | -1.028 | -0.872 | 9:8 | 149/150 | C:K:I:T:S | 87 | 0.9157894736842105 | 91 | effect | pnca_p.thr47pro | 0.0001437401178668 | -9.98752126245062 | 4.5970013133425e-05 | 0.942832958100734 | 139.277183325398 | -0.071709672926946 | 144471.70631486 | 1.2119588062211 | 0.0834878586628579 | 0.0 | 1.0 | 0.0 | 0.0 | 25.8386585962163 | 1.0105682238915901e-25 | 0.999999999999746 | -1.52 | -0.3979057591623037 | Destabilising | PRO | 0 | pnca_complex.pdb | |
| 110 | T47A | T | 47 | A | A | PZA | 7.502999999999999 | -1.71 | Destabilising | -2.172 | Destabilising | -0.441860465116279 | -0.5501519756838905 | T47 | TA47 | 2.87617 | 4.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 6.0 | 0.0 | 4.0 | 2.0 | 12.0 | 0.0 | 6.0 | 9.0 | 0.10475637205981979 | Destabilising | -2.276 | Destabilising | -0.3880647911338448 | 0 | 0.0 | E | strand | -0.9333333333333332 | 10.3 | THR | -0.925 | -0.7619439868204284 | 8 | 8 | -1.028 | -0.872 | 9:8 | 149/150 | C:K:I:T:S | 58 | 0.6105263157894737 | 75 | effect | pnca_p.thr47ala | 0.0008624407072013 | 1.58071061571228 | 4.85840704522462 | 0.0062231325401172 | 0.577790125858072 | 2.73578682807148 | 1.51864513964879 | 15.5428887748675 | 4.85840707964602 | 0.686493900966672 | 4.85767795624558 | 0.0089768751657447 | 2.04687481416212 | 1.29740576993775 | 18.1865471788576 | 6.99654790120219 | 0.0081667056971109 | -0.77 | -0.2015706806282722 | Destabilising | ALA | 0 | pnca_complex.pdb |
| 111 | K48E | K | 48 | E | A | PZA | 7.546 | -1.833 | Destabilising | -1.91 | Destabilising | -0.4736434108527132 | -0.483789260385005 | K48 | KA48 | 2.3862 | 28.0 | -28.0 | 0.0 | 0.0 | -28.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.0 | 0.0 | 2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 1.0 | 0.0 | 0.0 | 1.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.08691059812498635 | Destabilising | -1.921 | Destabilising | -0.32753623188405795 | 19 | 0.0805084745762711 | E | strand | -2.7 | 6.78 | LYS | -0.823 | -0.6779242174629324 | 8 | 8 | -0.914 | -0.779 | 8:8 | 149/150 | I:K:R:L:Q:A | 53 | 0.5578947368421052 | 75 | effect | pnca_p.lys48glu | 0.000646830530401 | 1.80360630763137 | 6.07150374077153 | 0.00720618942243 | 0.671193623356544 | 2.68716245933892 | 1.60530087074952 | 24.5460966015952 | 6.07150379106992 | 0.783296270528047 | 6.07036843596735 | 0.0099794518593429 | 2.00089331252028 | 1.30550120941319 | 30.6177596174465 | 6.87801392972404 | 0.0087262477054536 | -1.95 | -0.5104712041884817 | Destabilising | GLU | 0 | pnca_complex.pdb |
| 112 | K48T | K | 48 | T | A | PZA | 7.546 | -1.92 | Destabilising | -2.085 | Destabilising | -0.4961240310077519 | -0.5281155015197568 | K48 | KA48 | 2.8148 | 58.0 | 24.0 | 0.0 | 0.0 | 24.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.0 | 0.0 | 2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 1.0 | 0.0 | -1.0 | 2.0 | 0.0 | 0.0 | 4.0 | -2.0 | 0.10252114307359465 | Destabilising | 0.126 | Stabilising | 0.10641891891891893 | 19 | 0.0805084745762711 | E | strand | -2.7 | 6.78 | LYS | -0.823 | -0.6779242174629324 | 8 | 8 | -0.914 | -0.779 | 8:8 | 149/150 | I:K:R:L:Q:A | 63 | 0.6631578947368421 | 80 | effect | pnca_p.lys48thr | 0.0011499209429351 | 1.32955743902485 | 3.77937041554348 | 0.0083975040006128 | 0.504450465587511 | 2.6356550934617 | 1.34958413760038 | 10.1533105792859 | 3.77937043282743 | 0.577419461128044 | 3.77886521261346 | 0.0115372080052907 | 1.93789927736761 | 1.1946979725449 | 11.4155701668003 | 6.25531101162114 | 0.0123821507399189 | -1.82 | -0.4764397905759163 | Destabilising | THR | 0 | pnca_complex.pdb |
| 113 | K48Q | K | 48 | Q | A | PZA | 7.546 | -1.537 | Destabilising | -1.653 | Destabilising | -0.397157622739018 | -0.418693009118541 | K48 | KA48 | 1.3897700000000002 | 28.0 | 24.0 | 0.0 | 0.0 | 24.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.0 | -2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.0 | 0.0 | 1.0 | 1.0 | 2.0 | 0.0 | 2.0 | -4.0 | 0.0506184485609598 | Destabilising | -0.028 | Destabilising | -0.004774083546462063 | 19 | 0.0805084745762711 | E | strand | -2.7 | 6.78 | LYS | -0.823 | -0.6779242174629324 | 8 | 8 | -0.914 | -0.779 | 8:8 | 149/150 | I:K:R:L:Q:A | -61 | -0.6559139784946236 | 82 | neutral | -1.89 | -0.4947643979057591 | Destabilising | GLN | 0 | pnca_complex.pdb | ||||||||||||||||||
| 114 | K48N | K | 48 | N | A | PZA | 7.546 | -2.178 | Destabilising | -1.168 | Destabilising | -0.5627906976744186 | -0.2958459979736575 | K48 | KA48 | 2.2078 | 46.0 | 24.0 | 0.0 | 0.0 | 24.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -2.0 | 1.0 | 2.0 | 0.0 | 0.0 | -2.0 | 0.08041288179546763 | Destabilising | -2.869 | Destabilising | -0.48917306052855924 | 19 | 0.0805084745762711 | E | strand | -2.7 | 6.78 | LYS | -0.823 | -0.6779242174629324 | 8 | 8 | -0.914 | -0.779 | 8:8 | 149/150 | I:K:R:L:Q:A | 67 | 0.7052631578947368 | 80 | effect | pnca_p.lys48asn | 0.0001437401178668 | -9.9875212624506 | 4.59700131334259e-05 | 0.942832958100734 | 139.277183325398 | -0.0717096729269463 | 144471.706314829 | 1.2119588062211 | 0.0834878586628579 | 0.0 | 1.0 | 0.0 | 0.0 | 25.8386585962163 | 1.0105682238915901e-25 | 0.999999999999746 | -1.86 | -0.486910994764398 | Destabilising | ASN | 0 | pnca_complex.pdb | |
| 115 | D49G | D | 49 | G | A | PZA | 3.452 | -1.157 | Destabilising | -3.463 | Destabilising | -0.2989664082687338 | -0.8771529888551165 | D49 | DA49 | 0.460983 | 28.0 | 30.0 | 0.0 | 0.0 | 30.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -1.0 | 6.0 | 0.0 | 9.0 | 19.0 | 0.016790004297816855 | Destabilising | -2.415 | Destabilising | -0.4117647058823529 | 7 | 0.0362694300518134 | E | strand | -1.5333333333333332 | 7.89 | ASP | -1.188 | -0.9785831960461285 | 9 | 9 | -1.221 | -1.178 | 9:9 | 149/150 | T:D | 83 | 0.8736842105263158 | 91 | effect | pnca_p.asp49gly | 0.0005030904125341 | 3.37290329402599 | 29.1630732435189 | 0.0017890770828182 | 1.07995768762032 | 3.12318096596744 | 4.97876379054023 | 550.894323518622 | 29.1630847029077 | 1.46483345924118 | 29.1293325978315 | 0.0001485295621003 | 3.828187099348 | 3.53443753556636 | 1331.56873199938 | 18.6717493808583 | 1.55265977742841e-05 | -1.08 | -0.2827225130890052 | Destabilising | GLY | 0 | pnca_complex.pdb |
| 116 | D49N | D | 49 | N | A | PZA | 3.452 | -1.6840000000000002 | Destabilising | -1.932 | Destabilising | -0.4351421188630491 | -0.4893617021276595 | D49 | DA49 | -0.334669 | 0.0 | 32.0 | 0.0 | 0.0 | 32.0 | 0.0 | 0.0 | 0.0 | 0.0 | -2.0 | 0.0 | 0.0 | -2.0 | 0.0 | 0.0 | 0.0 | 0.0 | -6.0 | 0.0 | 0.0 | -6.0 | -2.0 | 0.0 | 0.0 | 0.0 | -0.064344574329001 | Stabilising | -2.857 | Destabilising | -0.4871270247229327 | 7 | 0.0362694300518134 | E | strand | -1.5333333333333332 | 7.89 | ASP | -1.188 | -0.9785831960461285 | 9 | 9 | -1.221 | -1.178 | 9:9 | 149/150 | T:D | 76 | 0.8 | 85 | effect | pnca_p.asp49asn | 0.0005749604714675 | 14.148137089499 | 1394626.35223403 | 0.901927875940367 | 114.814237034002 | 0.123226330244298 | 82.9586021424457 | 77.8405735976381 | 1.89120602753485 | inf | 7.2326389241213e-07 | 6.1407032156959 | 8.29603358299821 | inf | 33.1802749271012 | 8.399830460993881e-09 | -1.45 | -0.3795811518324607 | Destabilising | ASN | 0 | pnca_complex.pdb | |
| 117 | D49A | D | 49 | A | A | PZA | 3.452 | -0.451 | Destabilising | -3.3480000000000003 | Destabilising | -0.1165374677002584 | -0.8480243161094225 | D49 | DA49 | -2.06724 | 20.0 | 28.0 | 0.0 | 0.0 | 28.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -5.0 | 0.0 | 0.0 | -5.0 | 0.0 | 0.0 | 2.0 | 3.0 | -0.3974544335922479 | Stabilising | -1.72 | Destabilising | -0.2932651321398124 | 7 | 0.0362694300518134 | E | strand | -1.5333333333333332 | 7.89 | ASP | -1.188 | -0.9785831960461285 | 9 | 9 | -1.221 | -1.178 | 9:9 | 149/150 | T:D | 73 | 0.7684210526315789 | 85 | effect | pnca_p.asp49ala | 0.0004312203536006 | 14.1472939191285 | 1393450.9402217 | 0.915018435774987 | 132.576060676241 | 0.106710773023171 | 4.17896182049081 | 58.3312262958281 | 1.7659011066874 | inf | 2.48532104922106e-05 | 4.60461750194108 | 5.71767556863798 | inf | 23.547488635408 | 1.21868387173808e-06 | -1.56 | -0.4083769633507854 | Destabilising | ALA | 0 | pnca_complex.pdb | |
| 118 | D49E | D | 49 | E | A | PZA | 3.452 | -0.472 | Destabilising | 0.251 | Stabilising | -0.1219638242894056 | 0.1125560538116591 | D49 | DA49 | -0.696543 | -22.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -5.0 | 0.0 | -1.0 | -6.0 | -10.0 | 0.0 | -6.0 | -8.0 | -0.13391967238329616 | Stabilising | -2.35 | Destabilising | -0.40068201193520886 | 7 | 0.0362694300518134 | E | strand | -1.5333333333333332 | 7.89 | ASP | -1.188 | -0.9785831960461285 | 9 | 9 | -1.221 | -1.178 | 9:9 | 149/150 | T:D | 75 | 0.7894736842105263 | 85 | effect | pnca_p.asp49glu | 0.0002156101768003 | 2.27260607808817 | 9.70465898653052 | 0.0634455902260897 | 1.22442760158496 | 1.8560559033024 | 0.929172866365932 | 208.881603004782 | 9.70466975178797 | 0.986980761010679 | 9.70194990589383 | 0.0776844925942494 | 1.10966566656461 | 0.504888890842109 | 570.372842410328 | 2.29168245016684 | 0.130068862702538 | -0.28 | -0.0732984293193717 | Destabilising | GLU | 0 | pnca_complex.pdb |
| 119 | D49Y | D | 49 | Y | A | PZA | 3.452 | -0.7390000000000001 | Destabilising | -1.855 | Destabilising | -0.1909560723514212 | -0.4698581560283688 | D49 | DA49 | -2.66914 | -42.0 | 20.0 | 0.0 | 0.0 | 20.0 | 0.0 | 0.0 | 0.0 | 0.0 | -2.0 | 0.0 | 0.0 | -4.0 | 0.0 | 0.0 | 0.0 | 0.0 | -14.0 | 0.0 | -4.0 | -10.0 | -14.0 | 0.0 | -12.0 | -12.0 | -0.5131777282165654 | Stabilising | -0.988 | Destabilising | -0.16845694799658995 | 7 | 0.0362694300518134 | E | strand | -1.5333333333333332 | 7.89 | ASP | -1.188 | -0.9785831960461285 | 9 | 9 | -1.221 | -1.178 | 9:9 | 149/150 | T:D | 85 | 0.8947368421052632 | 91 | effect | pnca_p.asp49tyr | 7.18700589334483e-05 | 12.1451538387266 | 188179.926264654 | 0.919026337424238 | 119.468044436239 | 0.10166027154825 | 5.0115366606202e-06 | 9.70142977291842 | 0.986835744238421 | inf | 0.170978870202674 | 0.767057556984365 | 0.124324963210678 | inf | 0.763784339928386 | 0.382146811758261 | -1.64 | -0.4293193717277487 | Destabilising | TYR | 0 | pnca_complex.pdb | |
| 120 | H51P | H | 51 | P | A | PZA | 5.6610000000000005 | -1.7619999999999998 | Destabilising | -2.624 | Destabilising | -0.4552971576227389 | -0.6646403242147922 | H51 | HA51 | 2.82591 | 28.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 4.0 | 2.0 | 2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -2.0 | 2.0 | 4.0 | 0.0 | 6.0 | 2.0 | 0.10292579345712016 | Destabilising | -1.529 | Destabilising | -0.2606990622335891 | 1 | 0.0044642857142857 | B | strand | 1.3666666666666665 | 6.97 | HIS | -1.189 | -0.9794069192751236 | 9 | 9 | -1.221 | -1.178 | 9:9 | 149/150 | H:Y | 82 | 0.8631578947368421 | 91 | effect | pnca_p.his51pro | 0.0002156101768003 | 0.885806606247285 | 2.42493957425811 | 0.469406216824825 | 1.22442753211922 | 0.723445514749364 | 0.112662937620387 | 25.3270547471172 | 2.42493692178301 | 0.384700446081433 | 2.42473736947533 | 0.430258985168156 | 0.366270051463612 | 0.0410854444106247 | 46.5881472867033 | 4.31445715363782e-25 | 0.999999999999476 | -0.98 | -0.256544502617801 | Destabilising | PRO | 0 | pnca_complex.pdb |
| 121 | H51N | H | 51 | N | A | PZA | 5.6610000000000005 | -2.215 | Destabilising | -1.063 | Destabilising | -0.5723514211886305 | -0.2692502532928065 | H51 | HA51 | 1.03208 | 14.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -4.0 | 0.0 | 2.0 | 0.0 | 0.03759060016462824 | Destabilising | -2.201 | Destabilising | -0.3752770673486786 | 1 | 0.0044642857142857 | B | strand | 1.3666666666666665 | 6.97 | HIS | -1.189 | -0.9794069192751236 | 9 | 9 | -1.221 | -1.178 | 9:9 | 149/150 | H:Y | 70 | 0.7368421052631579 | 85 | effect | -1.83 | -0.4790575916230367 | Destabilising | ASN | 0 | pnca_complex.pdb | ||||||||||||||||||
| 122 | H51Q | H | 51 | Q | A | PZA | 5.6610000000000005 | -1.714 | Destabilising | -1.42 | Destabilising | -0.4428940568475452 | -0.3596757852077001 | H51 | HA51 | -1.10489 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -4.0 | 0.0 | -2.0 | -2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.0 | 0.0 | 2.0 | 0.0 | -6.0 | 0.0 | -2.0 | -4.0 | -0.21242982388679535 | Stabilising | -1.18 | Destabilising | -0.2011935208866155 | 1 | 0.0044642857142857 | B | strand | 1.3666666666666665 | 6.97 | HIS | -1.189 | -0.9794069192751236 | 9 | 9 | -1.221 | -1.178 | 9:9 | 149/150 | H:Y | 65 | 0.6842105263157895 | 80 | effect | pnca_p.his51gln | 0.0004312203536006 | 3.19016080361872 | 24.29233342416 | 0.0035954281300595 | 1.09565968954934 | 2.91163472932995 | 3.91551977432275 | 465.531063220863 | 24.2923336141533 | 1.38546923679232 | 24.2833096922897 | 0.0007494070007895 | 3.12528225414311 | 2.71567844828345 | 1141.60089496884 | 14.1977442691074 | 0.0001645676755807 | -1.75 | -0.4581151832460733 | Destabilising | GLN | 0 | pnca_complex.pdb |
| 123 | H51D | H | 51 | D | A | PZA | 5.6610000000000005 | -2.198 | Destabilising | -1.821 | Destabilising | -0.5679586563307494 | -0.4612462006079027 | H51 | HA51 | 4.34022 | 16.0 | -28.0 | 0.0 | 0.0 | -28.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.0 | 0.0 | 2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 4.0 | 0.0 | 2.0 | 2.0 | 2.0 | 0.0 | 4.0 | 4.0 | 0.1580802599086532 | Destabilising | -1.814 | Destabilising | -0.3092924126172208 | 1 | 0.0044642857142857 | B | strand | 1.3666666666666665 | 6.97 | HIS | -1.189 | -0.9794069192751236 | 9 | 9 | -1.221 | -1.178 | 9:9 | 149/150 | H:Y | 82 | 0.8631578947368421 | 91 | effect | pnca_p.his51asp | 0.0030185424752048 | 16.1625856127882 | 10454944.8180635 | 0.905545449550291 | 136.210261834263 | 0.118659089228199 | 26043.5577250657 | 1.23987518604392e+26 | 414.608472400514 | 2.61763817252677 | inf | 4.4914140361843e-33 | 32.347616908121 | 53.6831618314533 | inf | 198.436695636911 | 4.58127580776551e-45 | -1.67 | -0.4371727748691099 | Destabilising | ASP | 0 | pnca_complex.pdb |
| 124 | H51Y | H | 51 | Y | A | PZA | 5.6610000000000005 | 0.122 | Stabilising | -2.046 | Destabilising | 0.1037414965986394 | -0.5182370820668692 | H51 | HA51 | -1.10156 | -18.0 | -6.0 | 0.0 | 0.0 | -6.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.0 | 0.0 | 2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -4.0 | 0.0 | 2.0 | -6.0 | -2.0 | 0.0 | 4.0 | -4.0 | -0.21178958701838038 | Stabilising | -0.891 | Destabilising | -0.15191815856777494 | 1 | 0.0044642857142857 | B | strand | 1.3666666666666665 | 6.97 | HIS | -1.189 | -0.9794069192751236 | 9 | 9 | -1.221 | -1.178 | 9:9 | 149/150 | H:Y | 60 | 0.631578947368421 | 80 | effect | pnca_p.his51tyr | 0.0002156101768003 | 2.27260607808817 | 9.70465898653051 | 0.0634455902260897 | 1.22442760158496 | 1.8560559033024 | 0.929172866365331 | 208.881603005168 | 9.70466975178797 | 0.986980761010679 | 9.70194990589383 | 0.0776844925942494 | 1.10966566656461 | 0.504888890842109 | 570.372842410328 | 2.29168245016684 | 0.130068862702538 | 0.41 | 0.2303370786516853 | Stabilising | TYR | 0 | pnca_complex.pdb |
| 125 | H51R | H | 51 | R | A | PZA | 5.6610000000000005 | -1.766 | Destabilising | -0.862 | Destabilising | -0.4563307493540051 | -0.218338399189463 | H51 | HA51 | 2.7037 | -32.0 | -2.0 | 0.0 | 0.0 | -2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.0 | -2.0 | 0.0 | 0.0 | 0.0 | 0.0 | -10.0 | 0.0 | -2.0 | -9.0 | 0.0 | 0.0 | 2.0 | -2.0 | 0.09847463923833943 | Destabilising | -1.252 | Destabilising | -0.2134697357203751 | 1 | 0.0044642857142857 | B | strand | 1.3666666666666665 | 6.97 | HIS | -1.189 | -0.9794069192751236 | 9 | 9 | -1.221 | -1.178 | 9:9 | 149/150 | H:Y | 74 | 0.7789473684210526 | 85 | effect | pnca_p.his51arg | 0.001293661060802 | 3.19420858638167 | 24.3908627908724 | 4.47975895465189e-07 | 0.632848408547862 | 5.04735185115046 | 8.04148719104289 | 105.368248724156 | 24.3908629441624 | 1.38722716584297 | 24.3817411979725 | 1.4579789128422702e-09 | 8.83624875729546 | 6.89001106760784 | 131.337835841673 | 51.2029377973759 | 8.32938806400108e-13 | -1.48 | -0.387434554973822 | Destabilising | ARG | 0 | pnca_complex.pdb |
| 126 | I52T | I | 52 | T | A | PZA | 12.353 | -1.196 | Destabilising | 0.529 | Stabilising | -0.3090439276485788 | 0.237219730941704 | I52 | IA52 | 0.950846 | 6.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -2.0 | 0.0 | 0.0 | -2.0 | 0.0 | 0.0 | 0.0 | 0.0 | -1.0 | 0.0 | -3.0 | 0.0 | 0.0 | 0.0 | 0.0 | -2.0 | 0.034631881059739654 | Destabilising | -1.262 | Destabilising | -0.21517476555839726 | 82 | 0.416243654822335 | S | loop | -0.7333333333333334 | 4.09 | ILE | -0.518 | -0.4266886326194399 | 7 | 7 | -0.674 | -0.411 | 7:7 | 149/150 | N:L:V:I:S:T:P:D | 26 | 0.2736842105263158 | 63 | effect | -1.33 | -0.3481675392670157 | Destabilising | THR | 0 | pnca_complex.pdb | ||||||||||||||||||
| 127 | D53E | D | 53 | E | A | PZA | 13.16 | -0.145 | Destabilising | -0.123 | Destabilising | -0.0374677002583979 | -0.0311550151975683 | D53 | DA53 | 0.906346 | -6.0 | 2.0 | 0.0 | 0.0 | 2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -1.0 | 0.0 | -1.0 | 0.0 | -2.0 | 0.0 | -2.0 | 0.0 | 0.03301109419503347 | Destabilising | -0.467 | Destabilising | -0.07962489343563513 | 103 | 0.533678756476684 | - | loop | -0.2 | 3.83 | ASP | 0.498 | 0.1596153846153846 | 3 | 3 | 0.225 | 0.59 | 4:3 | 148/150 | D:P:S:G:A:I:R:L:N:V:Q:E:H | -39 | -0.41935483870967744 | 66 | neutral | pnca_p.asp53glu | 7.18700589334483e-05 | -8.9874087814964 | 0.0001249735077034 | 0.940032862253633 | 119.468044435491 | -0.0752285585987752 | 4692673.51081297 | 2.42412778478352 | 0.384555509373631 | 0.0 | 1.0 | 0.0 | 0.0 | 188.544222231268 | 1.0341007080334399e-29 | 0.999999999999997 | 0.14 | 0.0786516853932584 | Stabilising | GLU | 0 | pnca_complex.pdb | |
| 128 | P54A | P | 54 | A | A | PZA | 9.765 | -1.416 | Destabilising | -1.785 | Destabilising | -0.365891472868217 | -0.452127659574468 | P54 | PA54 | 2.25796 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -1.0 | 0.0 | -1.0 | 0.0 | 0.0 | 0.0 | 0.0 | 1.0 | 0.08223981818049375 | Destabilising | -1.236 | Destabilising | -0.21074168797953963 | 8 | 0.050314465408805 | - | loop | -1.8333333333333333 | 4.91 | PRO | -0.129 | -0.10626029654036244 | 5 | 5 | -0.332 | -0.038 | 6:5 | 148/150 | Q:E:H:K:V:N:P:A:G:S:D | 25 | 0.2631578947368421 | 63 | effect | pnca_p.pro54ala | 7.18700589334483e-05 | -8.98740878149641 | 0.0001249735077034 | 0.940032862253633 | 119.468044435491 | -0.0752285585987755 | 4692673.51081266 | 2.42412778478352 | 0.384555509373631 | 0.0 | 1.0 | 0.0 | 0.0 | 188.544222231268 | 1.0341007080334399e-29 | 0.999999999999997 | -1.58 | -0.4136125654450262 | Destabilising | ALA | 0 | pnca_complex.pdb | |
| 129 | P54L | P | 54 | L | A | PZA | 9.765 | -0.0969999999999999 | Destabilising | -1.77 | Destabilising | -0.0250645994832041 | -0.4483282674772036 | P54 | PA54 | 3.46567 | -16.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -10.0 | 0.0 | -6.0 | -4.0 | -2.0 | 0.0 | -2.0 | -2.0 | 0.12622724524508483 | Destabilising | -0.95 | Destabilising | -0.1619778346121057 | 8 | 0.050314465408805 | - | loop | -1.8333333333333333 | 4.91 | PRO | -0.129 | -0.10626029654036244 | 5 | 5 | -0.332 | -0.038 | 6:5 | 148/150 | Q:E:H:K:V:N:P:A:G:S:D | 33 | 0.3473684210526316 | 66 | effect | pnca_p.pro54leu | 0.0023717119448037 | 3.09367684201887 | 22.0580329576526 | 7.52888191547387e-12 | 0.451813758844646 | 6.84723911447463 | 9.73717599077908 | 59.1593944160241 | 22.0580357142857 | 1.34356683555525 | 22.0491621136906 | 6.54726814958295e-16 | 15.1839398717709 | 8.90776823243485 | 65.3653818513773 | 93.2270586345296 | 4.6626285706706e-22 | -0.4 | -0.1047120418848167 | Destabilising | LEU | 0 | pnca_complex.pdb |
| 130 | P54S | P | 54 | S | A | PZA | 9.765 | -1.837 | Destabilising | -0.307 | Destabilising | -0.4746770025839793 | -0.0777608915906788 | P54 | PA54 | 1.58683 | 0.0 | -4.0 | 0.0 | 0.0 | -4.0 | 0.0 | 0.0 | 0.0 | 0.0 | -6.0 | 0.0 | 2.0 | -8.0 | 0.0 | 0.0 | 0.0 | 0.0 | -7.0 | 0.0 | -3.0 | -2.0 | -6.0 | 0.0 | -6.0 | -4.0 | 0.057795802708353064 | Destabilising | -1.286 | Destabilising | -0.21926683716965045 | 8 | 0.050314465408805 | - | loop | -1.8333333333333333 | 4.91 | PRO | -0.129 | -0.10626029654036244 | 5 | 5 | -0.332 | -0.038 | 6:5 | 148/150 | Q:E:H:K:V:N:P:A:G:S:D | 26 | 0.2736842105263158 | 63 | effect | pnca_p.pro54ser | 0.0002156101768003 | 2.27260607808816 | 9.70465898653047 | 0.0634455902260904 | 1.22442760158496 | 1.8560559033024 | 0.929172866366028 | 208.88160300516 | 9.70466975178797 | 0.986980761010679 | 9.70194990589383 | 0.0776844925942494 | 1.10966566656461 | 0.504888890842109 | 570.372842410328 | 2.29168245016684 | 0.130068862702538 | -1.76 | -0.4607329842931937 | Destabilising | SER | 0 | pnca_complex.pdb |
| 131 | P54Q | P | 54 | Q | A | PZA | 9.765 | -1.251 | Destabilising | -0.084 | Destabilising | -0.3232558139534883 | -0.0212765957446808 | P54 | PA54 | 9.94224 | -16.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -3.0 | 0.0 | -1.0 | -2.0 | 0.0 | 0.0 | 0.0 | 0.0 | -8.0 | 0.0 | -8.0 | -4.0 | -10.0 | 0.0 | -8.0 | -6.0 | 0.362118022421492 | Destabilising | -1.258 | Destabilising | -0.2144927536231884 | 8 | 0.050314465408805 | - | loop | -1.8333333333333333 | 4.91 | PRO | -0.129 | -0.10626029654036244 | 5 | 5 | -0.332 | -0.038 | 6:5 | 148/150 | Q:E:H:K:V:N:P:A:G:S:D | 8 | 0.08421052631578947 | 53 | effect | pnca_p.pro54gln | 0.0003593502946672 | 2.96659528728018 | 19.4256680571768 | 0.0079500503166053 | 1.11770528264822 | 2.65418382943607 | 2.872152136516 | 380.097158975598 | 19.4256842105263 | 1.28837632444196 | 19.4169790983636 | 0.0036816889015929 | 2.43395291165754 | 1.92061868691892 | 951.403114304703 | 9.87561363723508 | 0.0016748373055023 | -1.64 | -0.4293193717277487 | Destabilising | GLN | 0 | pnca_complex.pdb |
| 132 | P54R | P | 54 | R | A | PZA | 9.765 | -0.884 | Destabilising | -0.957 | Destabilising | -0.2284237726098191 | -0.2424012158054711 | P54 | PA54 | 7.062289999999999 | -40.0 | -24.0 | 0.0 | 0.0 | -24.0 | 0.0 | 0.0 | 0.0 | 0.0 | -4.0 | 0.0 | 0.0 | -4.0 | 0.0 | 0.0 | 0.0 | 0.0 | -19.0 | 0.0 | -8.0 | -16.0 | -12.0 | 0.0 | -12.0 | -12.0 | 0.257223974533614 | Destabilising | -1.269 | Destabilising | -0.21636828644501277 | 8 | 0.050314465408805 | - | loop | -1.8333333333333333 | 4.91 | PRO | -0.129 | -0.10626029654036244 | 5 | 5 | -0.332 | -0.038 | 6:5 | 148/150 | Q:E:H:K:V:N:P:A:G:S:D | 33 | 0.3473684210526316 | 66 | effect | pnca_p.pro54arg | 0.0001437401178668 | 13.14560022562 | 511754.463552342 | 0.924803768446982 | 139.27718332653 | 0.0943844491369463 | 0.0001628371344461 | 19.411022297013 | 1.28804840845689 | inf | 0.0292235860951597 | 1.53426649183163 | 0.91081598550184 | inf | 4.73122070382274 | 0.0296198560706035 | -0.35 | -0.0916230366492146 | Destabilising | ARG | 0 | pnca_complex.pdb | |
| 133 | G55S | G | 55 | S | A | PZA | 12.27 | -0.912 | Destabilising | 0.5589999999999999 | Stabilising | -0.2356589147286821 | 0.2506726457399102 | G55 | GA55 | 0.441313 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -2.0 | 0.0 | -2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -2.0 | 0.0 | -4.0 | 0.0 | 0.0 | 0.0 | -3.0 | -7.0 | 0.016073580081439987 | Destabilising | -1.035 | Destabilising | -0.1764705882352941 | 36 | 0.3461538461538461 | G | helix | -1.8333333333333333 | 3.54 | GLY | -1.036 | -0.8533772652388798 | 9 | 9 | -1.124 | -0.993 | 9:9 | 148/150 | T:H:S:A:G | 5 | 0.05263157894736842 | 53 | effect | 0.06 | 0.0337078651685393 | Stabilising | SER | 0 | pnca_complex.pdb | ||||||||||||||||||
| 134 | D56E | D | 56 | E | A | PZA | 11.133 | 0.434 | Stabilising | -0.01 | Destabilising | 0.369047619047619 | -0.0025329280648429 | D56 | DA56 | -0.915918 | -8.0 | -4.0 | 0.0 | 0.0 | -4.0 | 0.0 | 0.0 | 0.0 | 0.0 | -1.0 | 0.0 | -1.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -1.0 | 0.0 | 0.0 | 0.0 | 0.0 | -0.17609743905252634 | Stabilising | -0.032 | Destabilising | -0.005456095481670929 | 148 | 0.7668393782383419 | G | helix | -2.3666666666666667 | 3.47 | ASP | 2.366 | 0.7583333333333333 | 1 | 1 | 1.183 | 3.125 | 1:1 | 148/150 | D:P:S:A:G:T:K:C:R:I:L:V:E:Y | -78 | -0.8387096774193549 | 87 | neutral | 0.09 | 0.0505617977528089 | Stabilising | GLU | 0 | pnca_complex.pdb | ||||||||||||||||||
| 135 | H57Q | H | 57 | Q | A | PZA | 4.561 | -1.29 | Destabilising | -0.949 | Destabilising | -0.3333333333333333 | -0.2403748733535967 | H57 | HA57 | 0.8493200000000001 | -2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 1.0 | 0.0 | -1.0 | 2.0 | 0.0 | 0.0 | 0.0 | 0.0 | -2.0 | 0.0 | -2.0 | 2.0 | 0.0 | 0.0 | -2.0 | -2.0 | 0.030934083144545054 | Destabilising | -0.454 | Destabilising | -0.07740835464620631 | 16 | 0.0714285714285714 | G | helix | -1.3 | 5.63 | HIS | -1.177 | -0.9695222405271829 | 9 | 9 | -1.221 | -1.152 | 9:9 | 148/150 | H:S | 63 | 0.6631578947368421 | 80 | effect | -0.3 | -0.0785340314136125 | Destabilising | GLN | 0 | pnca_complex.pdb | ||||||||||||||||||
| 136 | H57L | H | 57 | L | A | PZA | 4.561 | -0.06 | Destabilising | -1.924 | Destabilising | -0.0155038759689922 | -0.4873353596757852 | H57 | HA57 | -1.11406 | 2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.0 | 0.0 | 0.0 | 2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -2.0 | 1.0 | 0.0 | 0.0 | -2.0 | 0.0 | -0.21419287856648467 | Stabilising | -0.541 | Destabilising | -0.09224211423699916 | 16 | 0.0714285714285714 | G | helix | -1.3 | 5.63 | HIS | -1.177 | -0.9695222405271829 | 9 | 9 | -1.221 | -1.152 | 9:9 | 148/150 | H:S | 68 | 0.7157894736842105 | 80 | effect | -0.64 | -0.1675392670157068 | Destabilising | LEU | 0 | pnca_complex.pdb | ||||||||||||||||||
| 137 | H57R | H | 57 | R | A | PZA | 4.561 | -1.171 | Destabilising | -0.281 | Destabilising | -0.3025839793281654 | -0.0711752786220871 | H57 | HA57 | 1.25273 | -20.0 | -28.0 | 0.0 | 0.0 | -28.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.0 | 0.0 | 0.0 | 2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -2.0 | 3.0 | 0.0 | 0.0 | -2.0 | 0.0 | 0.04562715346119945 | Destabilising | -0.843 | Destabilising | -0.14373401534526853 | 16 | 0.0714285714285714 | G | helix | -1.3 | 5.63 | HIS | -1.177 | -0.9695222405271829 | 9 | 9 | -1.221 | -1.152 | 9:9 | 148/150 | H:S | 76 | 0.8 | 85 | effect | pnca_p.his57arg | 0.0018686215322696 | 15.1557612752498 | 3820001.12562827 | 0.885234541058947 | 105.0027715034 | 0.144336773765625 | 15316.7789338948 | 2.0462689243807308e+16 | 254.917127071823 | 2.40639901531589 | inf | 1.0165082312418301e-20 | 19.9928891002838 | 32.1173872780919 | inf | 120.509921037495 | 4.89215110948636e-28 | -0.28 | -0.0732984293193717 | Destabilising | ARG | 0 | pnca_complex.pdb |
| 138 | H57D | H | 57 | D | A | PZA | 4.561 | -1.854 | Destabilising | -1.283 | Destabilising | -0.4790697674418605 | -0.3249746707193516 | H57 | HA57 | 1.83315 | 12.0 | -52.0 | 0.0 | 0.0 | -52.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.0 | 0.0 | 0.0 | 2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.0 | -2.0 | 0.0 | 0.0 | 0.0 | 0.06676731328171097 | Destabilising | -1.011 | Destabilising | -0.17237851662404088 | 16 | 0.0714285714285714 | G | helix | -1.3 | 5.63 | HIS | -1.177 | -0.9695222405271829 | 9 | 9 | -1.221 | -1.152 | 9:9 | 148/150 | H:S | 75 | 0.7894736842105263 | 85 | effect | pnca_p.his57asp | 0.0073307460112117 | 5.11745293904149 | 166.909698569351 | 2.3513585122013e-18 | 0.585586418334624 | 8.73902259139692 | 62.7783116073746 | 679.19417378895 | 166.910526315789 | 2.2224837265936 | 166.066117054134 | 2.0766131992924198e-72 | 71.6826443898669 | 55.3332327668776 | 812.938834180501 | 457.827712322676 | 1.42764749548143e-101 | -1.24 | -0.3246073298429319 | Destabilising | ASP | 0 | pnca_complex.pdb |
| 139 | H57P | H | 57 | P | A | PZA | 4.561 | -1.226 | Destabilising | -2.115 | Destabilising | -0.3167958656330749 | -0.5357142857142858 | H57 | HA57 | 0.15002 | 22.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 4.0 | 2.0 | 0.0 | 2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 3.0 | 4.0 | -3.0 | 4.0 | 2.0 | 0.0 | 0.0 | 4.0 | 0.005464054953780257 | Destabilising | -0.75 | Destabilising | -0.1278772378516624 | 16 | 0.0714285714285714 | G | helix | -1.3 | 5.63 | HIS | -1.177 | -0.9695222405271829 | 9 | 9 | -1.221 | -1.152 | 9:9 | 148/150 | H:S | 78 | 0.8210526315789474 | 85 | effect | pnca_p.his57pro | 0.0002874802357337 | 14.1464514590952 | 1392277.50785055 | 0.930573112990219 | 162.371849599067 | 0.0871237932808301 | 0.0113995443355766 | 38.8547368421053 | 1.58944397188817 | inf | 0.0008528275207519 | 3.06913879340442 | 3.20302487654751 | inf | 13.9909822352959 | 0.0001836895199759 | -0.33 | -0.0863874345549738 | Destabilising | PRO | 0 | pnca_complex.pdb | |
| 140 | H57Y | H | 57 | Y | A | PZA | 4.561 | 0.405 | Stabilising | -1.155 | Destabilising | 0.3443877551020408 | -0.2925531914893617 | H57 | HA57 | -0.147464 | -10.0 | -6.0 | 0.0 | 0.0 | -6.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -4.0 | 0.0 | -2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -0.028351918787972007 | Stabilising | -0.488 | Destabilising | -0.08320545609548166 | 16 | 0.0714285714285714 | G | helix | -1.3 | 5.63 | HIS | -1.177 | -0.9695222405271829 | 9 | 9 | -1.221 | -1.152 | 9:9 | 148/150 | H:S | 63 | 0.6631578947368421 | 80 | effect | pnca_p.his57tyr | 0.0002156101768003 | 13.1460210124991 | 511969.848428296 | 0.907969111549563 | 113.719344731871 | 0.115600569485296 | 0.183926936278874 | 29.1287878787879 | 1.4643224129316 | inf | 0.0049931328456149 | 2.3016268790981 | 2.00455510251839 | inf | 9.2872640727157 | 0.0023075254069185 | 0.9 | 0.5056179775280899 | Stabilising | TYR | 0 | pnca_complex.pdb | |
| 141 | F58L | F | 58 | L | A | PZA | 8.072000000000001 | -1.639 | Destabilising | -2.337 | Destabilising | -0.4235142118863049 | -0.5919452887537994 | F58 | FA58 | 0.155134 | 10.0 | 2.0 | 0.0 | 0.0 | 2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -3.0 | 0.0 | -3.0 | 1.0 | 2.0 | 0.0 | 6.0 | 0.0 | 0.0056503179656028964 | Destabilising | -0.746 | Destabilising | -0.12719522591645352 | 43 | 0.1791666666666666 | B | strand | -0.4000000000000001 | 4.41 | PHE | -1.108 | -0.9126853377265239 | 9 | 9 | -1.178 | -1.062 | 9:9 | 148/150 | W:I:F | 74 | 0.7789473684210526 | 85 | effect | pnca_p.phe58leu | 0.000646830530401 | 1.80360630763137 | 6.0715037407715 | 0.0072061894224301 | 0.671193623356544 | 2.68716245933892 | 1.60530087074952 | 24.5460966015953 | 6.07150379106992 | 0.783296270528047 | 6.07036843596735 | 0.0099794518593429 | 2.00089331252028 | 1.30550120941319 | 30.6177596174465 | 6.87801392972404 | 0.0087262477054536 | -1.43 | -0.3743455497382199 | Destabilising | LEU | 0 | pnca_complex.pdb |
| 142 | F58S | F | 58 | S | A | PZA | 8.072000000000001 | -2.784 | Destabilising | -0.8059999999999999 | Destabilising | -0.7193798449612402 | -0.2041540020263424 | F58 | FA58 | 2.9435 | 28.0 | 2.0 | 0.0 | 0.0 | 2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.0 | 6.0 | 0.0 | 10.0 | 2.0 | 0.10720867721938533 | Destabilising | -1.022 | Destabilising | -0.1742540494458653 | 43 | 0.1791666666666666 | B | strand | -0.4000000000000001 | 4.41 | PHE | -1.108 | -0.9126853377265239 | 9 | 9 | -1.178 | -1.062 | 9:9 | 148/150 | W:I:F | 78 | 0.8210526315789474 | 85 | effect | pnca_p.phe58ser | 0.0001437401178668 | 1.57903938912402 | 4.85029432717734 | 0.264247566376723 | 1.41439286276584 | 1.11640791656443 | 0.191756076673649 | 122.683760399218 | 4.85029436501262 | 0.685768096792206 | 4.84956447904112 | 0.312734154310187 | 0.504824686014995 | 0.061763864579114 | 379.558337204203 | 0.0881192621863332 | 0.766581879696361 | -3.0 | -0.7853403141361257 | Destabilising | SER | 0 | pnca_complex.pdb |
| 143 | F58V | F | 58 | V | A | PZA | 8.072000000000001 | -1.927 | Destabilising | -2.319 | Destabilising | -0.4979328165374676 | -0.587386018237082 | F58 | FA58 | 1.56433 | 28.0 | 2.0 | 0.0 | 0.0 | 2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.0 | -2.0 | 0.0 | 0.0 | 0.0 | 0.0 | -2.0 | 0.0 | -2.0 | 2.0 | 4.0 | 0.0 | 8.0 | -2.0 | 0.05697630373181623 | Destabilising | -1.103 | Destabilising | -0.18806479113384483 | 43 | 0.1791666666666666 | B | strand | -0.4000000000000001 | 4.41 | PHE | -1.108 | -0.9126853377265239 | 9 | 9 | -1.178 | -1.062 | 9:9 | 148/150 | W:I:F | 71 | 0.7473684210526316 | 85 | effect | pnca_p.phe58val | 7.18700589334483e-05 | -8.98740878149641 | 0.0001249735077034 | 0.940032862253633 | 119.468044435491 | -0.0752285585987755 | 4692673.51081266 | 2.42412778478352 | 0.384555509373631 | 0.0 | 1.0 | 0.0 | 0.0 | 188.544222231268 | 1.0341007080334399e-29 | 0.999999999999997 | -1.7 | -0.4450261780104712 | Destabilising | VAL | 0 | pnca_complex.pdb | |
| 144 | S59P | S | 59 | P | A | PZA | 11.829 | -0.594 | Destabilising | -1.097 | Destabilising | -0.1534883720930232 | -0.2778622087132725 | S59 | SA59 | 3.6058 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 4.0 | 2.0 | 2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -6.0 | 0.0 | -4.0 | -2.0 | -2.0 | 0.0 | -4.0 | -6.0 | 0.1313310848709562 | Destabilising | -1.13 | Destabilising | -0.19266837169650466 | 38 | 0.2451612903225806 | - | loop | 0.5333333333333333 | 3.86 | SER | -0.671 | -0.5527182866556838 | 7 | 7 | -0.779 | -0.615 | 8:7 | 148/150 | T:G:A:S:Q:H:E:K:R:L:V | 62 | 0.6526315789473685 | 80 | effect | pnca_p.ser59pro | 0.0004312203536006 | 14.1472939191327 | 1393450.94022764 | 0.915018435775139 | 132.57606067652 | 0.106710773022978 | 4.17896182039693 | 58.3312262958281 | 1.7659011066874 | inf | 2.48532104922106e-05 | 4.60461750194108 | 5.71767556863798 | inf | 23.547488635408 | 1.21868387173808e-06 | -0.16 | -0.0418848167539267 | Destabilising | PRO | 0 | pnca_complex.pdb | |
| 145 | S59F | S | 59 | F | A | PZA | 11.829 | -0.905 | Destabilising | -0.598 | Destabilising | -0.2338501291989664 | -0.1514690982776089 | S59 | SA59 | 0.176045 | -14.0 | -2.0 | 0.0 | 0.0 | -2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.0 | 0.0 | 2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -3.0 | 0.0 | -1.0 | -2.0 | -2.0 | 0.0 | -4.0 | -2.0 | 0.006411942103307863 | Destabilising | -1.083 | Destabilising | -0.1846547314578005 | 38 | 0.2451612903225806 | - | loop | 0.5333333333333333 | 3.86 | SER | -0.671 | -0.5527182866556838 | 7 | 7 | -0.779 | -0.615 | 8:7 | 148/150 | T:G:A:S:Q:H:E:K:R:L:V | 56 | 0.5894736842105263 | 75 | effect | pnca_p.ser59phe | 7.18700589334483e-05 | 12.1451538387252 | 188179.926264404 | 0.919026337424193 | 119.468044436159 | 0.101660271548307 | 5.01153666069521e-06 | 9.70142977291842 | 0.986835744238421 | inf | 0.170978870202674 | 0.767057556984365 | 0.124324963210678 | inf | 0.763784339928386 | 0.382146811758261 | -0.74 | -0.193717277486911 | Destabilising | PHE | 0 | pnca_complex.pdb | |
| 146 | S59Y | S | 59 | Y | A | PZA | 11.829 | -0.542 | Destabilising | -0.5529999999999999 | Destabilising | -0.1400516795865633 | -0.1400709219858155 | S59 | SA59 | 0.447426 | -22.0 | -2.0 | 0.0 | 0.0 | -2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.0 | 0.0 | 2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -1.0 | 0.0 | -1.0 | 0.0 | 0.0 | 0.0 | -2.0 | -2.0 | 0.01629622884782086 | Destabilising | -0.986 | Destabilising | -0.1681159420289855 | 38 | 0.2451612903225806 | - | loop | 0.5333333333333333 | 3.86 | SER | -0.671 | -0.5527182866556838 | 7 | 7 | -0.779 | -0.615 | 8:7 | 148/150 | T:G:A:S:Q:H:E:K:R:L:V | 58 | 0.6105263157894737 | 75 | effect | pnca_p.ser59tyr | 7.18700589334483e-05 | 12.1451538387264 | 188179.926264634 | 0.919026337424234 | 119.468044436232 | 0.101660271548256 | 5.0115366606273e-06 | 9.70142977291842 | 0.986835744238421 | inf | 0.170978870202674 | 0.767057556984365 | 0.124324963210678 | inf | 0.763784339928386 | 0.382146811758261 | -0.66 | -0.1727748691099476 | Destabilising | TYR | 0 | pnca_complex.pdb | |
| 147 | G60D | G | 60 | D | A | PZA | 14.904000000000002 | -0.161 | Destabilising | 0.52 | Stabilising | -0.0416020671834625 | 0.2331838565022421 | G60 | GA60 | -2.08267 | 0.0 | -8.0 | 0.0 | 0.0 | -8.0 | 0.0 | 0.0 | 0.0 | 0.0 | -4.0 | 0.0 | 0.0 | -4.0 | 0.0 | 0.0 | 0.0 | 0.0 | -1.0 | 0.0 | -1.0 | 0.0 | 0.0 | 0.0 | -1.0 | -7.0 | -0.40042105667922784 | Stabilising | 0.187 | Stabilising | 0.1579391891891892 | 80 | 0.7692307692307693 | S | loop | -0.6333333333333333 | 3.26 | GLY | 0.72 | 0.23076923076923075 | 2 | 2 | 0.389 | 0.842 | 4:2 | 148/150 | H:E:Q:N:L:V:K:I:T:A:S:G:P:D | -38 | -0.40860215053763443 | 66 | neutral | pnca_p.gly60asp | 7.18700589334483e-05 | -8.98740878149641 | 0.0001249735077034 | 0.940032862253634 | 119.468044435492 | -0.0752285585987745 | 4692673.51081424 | 2.42412778478352 | 0.384555509373631 | 0.0 | 1.0 | 0.0 | 0.0 | 188.544222231268 | 1.0341007080334399e-29 | 0.999999999999997 | -0.13 | -0.0340314136125654 | Destabilising | ASP | 0 | pnca_complex.pdb | |
| 148 | T61P | T | 61 | P | A | PZA | 14.618 | -0.204 | Destabilising | -0.472 | Destabilising | -0.0527131782945736 | -0.1195542046605876 | T61 | TA61 | 1.58134 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.0 | -2.0 | 0.0 | 0.0 | 0.0 | 0.0 | -2.0 | 0.057595844958078075 | Destabilising | -0.158 | Destabilising | -0.026939471440750214 | 130 | 0.7558139534883721 | S | loop | -0.9 | 3.48 | THR | 1.323 | 0.42403846153846153 | 1 | 1 | 0.842 | 1.712 | 2:1 | 124/150 | R:K:N:L:V:Q:H:E:D:P:T:A:G:S | -13 | -0.13978494623655913 | 57 | neutral | pnca_p.thr61pro | 7.18700589334483e-05 | -8.98740878149644 | 0.0001249735077034 | 0.940032862253633 | 119.468044435491 | -0.0752285585987752 | 4692673.51081345 | 2.42412778478352 | 0.384555509373631 | 0.0 | 1.0 | 0.0 | 0.0 | 188.544222231268 | 1.0341007080334399e-29 | 0.999999999999997 | 0.02 | 0.0112359550561797 | Stabilising | PRO | 0 | pnca_complex.pdb | |
| 149 | T61R | T | 61 | R | A | PZA | 14.618 | 0.174 | Stabilising | -0.01 | Destabilising | 0.1479591836734693 | -0.0025329280648429 | T61 | TA61 | -0.3629409999999999 | -8.0 | -4.0 | 0.0 | 0.0 | -4.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -1.0 | 0.0 | -1.0 | -1.0 | 0.0 | 0.0 | 0.0 | 0.0 | -0.06978024302084132 | Stabilising | -0.011 | Destabilising | -0.0018755328218243818 | 130 | 0.7558139534883721 | S | loop | -0.9 | 3.48 | THR | 1.323 | 0.42403846153846153 | 1 | 1 | 0.842 | 1.712 | 2:1 | 124/150 | R:K:N:L:V:Q:H:E:D:P:T:A:G:S | -37 | -0.3978494623655914 | 66 | neutral | -0.02 | -0.0052356020942408 | Destabilising | ARG | 0 | pnca_complex.pdb | ||||||||||||||||||
| 150 | P62L | P | 62 | L | A | PZA | 11.121 | -0.504 | Destabilising | -0.276 | Destabilising | -0.1302325581395348 | -0.0699088145896656 | P62 | PA62 | 1.7765799999999998 | 0.0 | -2.0 | 0.0 | 0.0 | -2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -1.0 | -2.0 | -7.0 | 1.0 | 2.0 | 0.0 | 4.0 | 2.0 | 0.06470691074381368 | Destabilising | -1.127 | Destabilising | -0.19215686274509802 | 34 | 0.2138364779874214 | - | loop | -1.9333333333333336 | 3.99 | PRO | -0.599 | -0.49341021416803954 | 7 | 7 | -0.779 | -0.485 | 8:7 | 125/150 | I:V:P:A:E | 54 | 0.5684210526315789 | 75 | effect | pnca_p.pro62leu | 0.0007905706482679 | 3.88541626053988 | 48.6872048041474 | 0.0002118075877292 | 1.0488367141091 | 3.70450062271154 | 9.31977387255173 | 893.783372292271 | 48.6872097931617 | 1.68741488635211 | 48.6746878162623 | 1.95392414212297e-07 | 6.70909230105579 | 6.91781679568266 | 2088.84994220519 | 37.2619168572472 | 1.03281930722422e-09 | -0.59 | -0.1544502617801047 | Destabilising | LEU | 0 | pnca_complex.pdb |
| 151 | P62S | P | 62 | S | A | PZA | 11.121 | -1.342 | Destabilising | 0.534 | Stabilising | -0.3467700258397932 | 0.2394618834080717 | P62 | PA62 | 1.54135 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -2.0 | 0.0 | -2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -3.0 | -2.0 | -1.0 | 0.0 | -4.0 | 0.0 | -4.0 | 0.0 | 0.05613932211044661 | Destabilising | -1.161 | Destabilising | -0.1979539641943734 | 34 | 0.2138364779874214 | - | loop | -1.9333333333333336 | 3.99 | PRO | -0.599 | -0.49341021416803954 | 7 | 7 | -0.779 | -0.485 | 8:7 | 125/150 | I:V:P:A:E | 50 | 0.5263157894736842 | 75 | effect | pnca_p.pro62ser | 0.0003593502946672 | 0.192485717774876 | 1.21225918982515 | 0.863268405978748 | 1.11770505415734 | 0.172215126932565 | 0.0619550849552706 | 8.19905671742343 | 1.21225820016821 | 0.083595130527928 | 1.212214074125 | 1.0 | 0.0 | 0.0246053772172713 | 12.260612593354 | 7.1929763849897505e-25 | 0.999999999999323 | -1.23 | -0.3219895287958115 | Destabilising | SER | 0 | pnca_complex.pdb |
| 152 | P62Q | P | 62 | Q | A | PZA | 11.121 | -0.763 | Destabilising | 0.708 | Stabilising | -0.197157622739018 | 0.3174887892376681 | P62 | PA62 | 1.97038 | -6.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -3.0 | 0.0 | -1.0 | -2.0 | 0.0 | 0.0 | 0.0 | 0.0 | -7.0 | -2.0 | -3.0 | -3.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.07176552859505096 | Destabilising | -0.98 | Destabilising | -0.1670929241261722 | 34 | 0.2138364779874214 | - | loop | -1.9333333333333336 | 3.99 | PRO | -0.599 | -0.49341021416803954 | 7 | 7 | -0.779 | -0.485 | 8:7 | 125/150 | I:V:P:A:E | 50 | 0.5263157894736842 | 75 | effect | -0.28 | -0.0732984293193717 | Destabilising | GLN | 0 | pnca_complex.pdb | ||||||||||||||||||
| 153 | P62T | P | 62 | T | A | PZA | 11.121 | -1.056 | Destabilising | 0.522 | Stabilising | -0.2728682170542635 | 0.2340807174887892 | P62 | PA62 | 2.20908 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -9.0 | -2.0 | -5.0 | -2.0 | -4.0 | 0.0 | -4.0 | 0.0 | 0.08045950218168839 | Destabilising | -1.242 | Destabilising | -0.21176470588235294 | 34 | 0.2138364779874214 | - | loop | -1.9333333333333336 | 3.99 | PRO | -0.599 | -0.49341021416803954 | 7 | 7 | -0.779 | -0.485 | 8:7 | 125/150 | I:V:P:A:E | 55 | 0.5789473684210527 | 75 | effect | pnca_p.pro62thr | 0.0002156101768003 | 13.1460210125009 | 511969.848429208 | 0.907969111549634 | 113.719344731975 | 0.115600569485207 | 0.183926936276724 | 29.1287878787879 | 1.4643224129316 | inf | 0.0049931328456149 | 2.3016268790981 | 2.00455510251839 | inf | 9.2872640727157 | 0.0023075254069185 | -0.58 | -0.1518324607329843 | Destabilising | THR | 0 | pnca_complex.pdb | |
| 154 | P62R | P | 62 | R | A | PZA | 11.121 | -0.186 | Destabilising | 0.023 | Stabilising | -0.0480620155038759 | 0.0103139013452914 | P62 | PA62 | 2.51854 | -20.0 | -14.0 | 0.0 | 0.0 | -14.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -7.0 | -2.0 | -1.0 | -5.0 | -2.0 | 0.0 | 0.0 | 0.0 | 0.09173070899409232 | Destabilising | -1.078 | Destabilising | -0.18380221653878942 | 34 | 0.2138364779874214 | - | loop | -1.9333333333333336 | 3.99 | PRO | -0.599 | -0.49341021416803954 | 7 | 7 | -0.779 | -0.485 | 8:7 | 125/150 | I:V:P:A:E | 61 | 0.6421052631578947 | 80 | effect | -0.18 | -0.0471204188481675 | Destabilising | ARG | 0 | pnca_complex.pdb | ||||||||||||||||||
| 155 | D63E | D | 63 | E | A | PZA | 10.737 | -0.2189999999999999 | Destabilising | -0.0139999999999999 | Destabilising | -0.0565891472868217 | -0.0035460992907801 | D63 | DA63 | 3.8992 | -4.0 | 6.0 | 0.0 | 0.0 | 6.0 | 0.0 | 0.0 | 0.0 | 0.0 | 4.0 | 0.0 | 6.0 | 2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.0 | 0.0 | 2.0 | 0.0 | 0.0 | 0.0 | 2.0 | 2.0 | 0.14201735152499653 | Destabilising | -0.86 | Destabilising | -0.1466325660699062 | 84 | 0.4352331606217616 | - | loop | -2.1333333333333333 | 3.62 | ASP | -0.741 | -0.6103789126853377 | 8 | 8 | -0.872 | -0.674 | 8:7 | 125/150 | W:D:M:G:N:F:Y:E | 32 | 0.3368421052631579 | 66 | effect | 0.02 | 0.0112359550561797 | Stabilising | GLU | 0 | pnca_complex.pdb | ||||||||||||||||||
| 156 | D63G | D | 63 | G | A | PZA | 10.737 | -1.153 | Destabilising | -0.799 | Destabilising | -0.2979328165374677 | -0.2023809523809523 | D63 | DA63 | 4.616219999999999 | 4.0 | 12.0 | 0.0 | 0.0 | 12.0 | 0.0 | 0.0 | 0.0 | 0.0 | 4.0 | 0.0 | 4.0 | 6.0 | 0.0 | 0.0 | 0.0 | 0.0 | 3.0 | 0.0 | 1.0 | 0.0 | 0.0 | 0.0 | 7.0 | 11.0 | 0.16813278068750498 | Destabilising | -0.964 | Destabilising | -0.16436487638533673 | 84 | 0.4352331606217616 | - | loop | -2.1333333333333333 | 3.62 | ASP | -0.741 | -0.6103789126853377 | 8 | 8 | -0.872 | -0.674 | 8:7 | 125/150 | W:D:M:G:N:F:Y:E | 33 | 0.3473684210526316 | 66 | effect | pnca_p.asp63gly | 0.0005749604714675 | 1.58004161593687 | 4.85515785897614 | 0.0255237229775361 | 0.70746570614631 | 2.23338262506551 | 1.14726850666831 | 20.5466864308595 | 4.85515789473684 | 0.686203358177678 | 4.85442845338892 | 0.033386534669467 | 1.47642865587913 | 0.903495684237988 | 26.0627135254866 | 4.01139112494925 | 0.0451938468216249 | -0.66 | -0.1727748691099476 | Destabilising | GLY | 0 | pnca_complex.pdb |
| 157 | D63Y | D | 63 | Y | A | PZA | 10.737 | 0.07 | Stabilising | -0.4379999999999999 | Destabilising | 0.0595238095238095 | -0.1109422492401215 | D63 | DA63 | 4.37717 | -6.0 | 12.0 | 0.0 | 0.0 | 12.0 | 0.0 | 0.0 | 0.0 | 0.0 | 4.0 | 0.0 | 4.0 | 6.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.0 | 0.0 | 2.0 | -2.0 | 0.0 | 0.0 | 2.0 | 0.0 | 0.15942605933901033 | Destabilising | -0.53 | Destabilising | -0.09036658141517477 | 84 | 0.4352331606217616 | - | loop | -2.1333333333333333 | 3.62 | ASP | -0.741 | -0.6103789126853377 | 8 | 8 | -0.872 | -0.674 | 8:7 | 125/150 | W:D:M:G:N:F:Y:E | 35 | 0.3684210526315789 | 66 | effect | pnca_p.asp63tyr | 7.18700589334483e-05 | -8.98740878149641 | 0.0001249735077034 | 0.940032862253634 | 119.468044435492 | -0.0752285585987744 | 4692673.51081431 | 2.42412778478352 | 0.384555509373631 | 0.0 | 1.0 | 0.0 | 0.0 | 188.544222231268 | 1.0341007080334399e-29 | 0.999999999999997 | 0.23 | 0.1292134831460674 | Stabilising | TYR | 0 | pnca_complex.pdb | |
| 158 | D63A | D | 63 | A | A | PZA | 10.737 | -0.7140000000000001 | Destabilising | -0.769 | Destabilising | -0.1844961240310077 | -0.1947821681864235 | D63 | DA63 | 4.4472 | 2.0 | 12.0 | 0.0 | 0.0 | 12.0 | 0.0 | 0.0 | 0.0 | 0.0 | 4.0 | 0.0 | 4.0 | 6.0 | 0.0 | 0.0 | 0.0 | 0.0 | 3.0 | 0.0 | 3.0 | 0.0 | 0.0 | 0.0 | 2.0 | 1.0 | 0.1619767043757603 | Destabilising | -0.704 | Destabilising | -0.12003410059676044 | 84 | 0.4352331606217616 | - | loop | -2.1333333333333333 | 3.62 | ASP | -0.741 | -0.6103789126853377 | 8 | 8 | -0.872 | -0.674 | 8:7 | 125/150 | W:D:M:G:N:F:Y:E | 40 | 0.42105263157894735 | 71 | effect | pnca_p.asp63ala | 0.0009343107661348 | 3.28791485229524 | 26.7869506340703 | 1.90630753051068e-05 | 0.768996545261043 | 4.275591187707 | 7.18677177005967 | 173.199151011581 | 26.7869510135135 | 1.42792328347145 | 26.7708032978517 | 1.9896368453757e-07 | 6.70122618511891 | 5.83859157504838 | 247.443798048456 | 37.2159659891988 | 1.0574446237829601e-09 | 0.12 | 0.0674157303370786 | Stabilising | ALA | 0 | pnca_complex.pdb |
| 159 | D63H | D | 63 | H | A | PZA | 10.737 | -0.085 | Destabilising | -0.456 | Destabilising | -0.0219638242894056 | -0.1155015197568389 | D63 | DA63 | 4.0904300000000005 | -4.0 | 6.0 | 0.0 | 0.0 | 6.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.0 | 0.0 | 2.0 | 6.0 | 0.0 | 0.0 | 0.0 | 0.0 | 3.0 | 0.0 | 3.0 | 0.0 | 0.0 | 0.0 | 2.0 | -2.0 | 0.14898236438202495 | Destabilising | -0.703 | Destabilising | -0.11986359761295821 | 84 | 0.4352331606217616 | - | loop | -2.1333333333333333 | 3.62 | ASP | -0.741 | -0.6103789126853377 | 8 | 8 | -0.872 | -0.674 | 8:7 | 125/150 | W:D:M:G:N:F:Y:E | 35 | 0.3684210526315789 | 66 | effect | pnca_p.asp63his | 0.0002156101768003 | 0.885806606247284 | 2.42493957425811 | 0.469406216824826 | 1.22442753211922 | 0.723445514749363 | 0.112662937620386 | 25.3270547471305 | 2.42493692178301 | 0.384700446081433 | 2.42473736947533 | 0.430258985168156 | 0.366270051463612 | 0.0410854444106247 | 46.5881472867033 | 4.31445715363782e-25 | 0.999999999999476 | 0.25 | 0.1404494382022472 | Stabilising | HIS | 0 | pnca_complex.pdb |
| 160 | D63V | D | 63 | V | A | PZA | 10.737 | 0.0279999999999999 | Stabilising | -0.722 | Destabilising | 0.0238095238095238 | -0.1828774062816616 | D63 | DA63 | 4.48687 | 0.0 | 12.0 | 0.0 | 0.0 | 12.0 | 0.0 | 0.0 | 0.0 | 0.0 | 4.0 | 0.0 | 4.0 | 6.0 | 0.0 | 0.0 | 0.0 | 0.0 | 1.0 | 0.0 | 1.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.16342157212683658 | Destabilising | -0.842 | Destabilising | -0.1435635123614663 | 84 | 0.4352331606217616 | - | loop | -2.1333333333333333 | 3.62 | ASP | -0.741 | -0.6103789126853377 | 8 | 8 | -0.872 | -0.674 | 8:7 | 125/150 | W:D:M:G:N:F:Y:E | 40 | 0.42105263157894735 | 71 | effect | -0.12 | -0.031413612565445 | Destabilising | VAL | 0 | pnca_complex.pdb | ||||||||||||||||||
| 161 | Y64D | Y | 64 | D | A | PZA | 8.434 | -0.392 | Destabilising | 0.546 | Stabilising | -0.1012919896640826 | 0.2448430493273543 | Y64 | YA64 | 2.59866 | 32.0 | -18.0 | 0.0 | 0.0 | -18.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 3.0 | 0.0 | -3.0 | 4.0 | 6.0 | 0.0 | 6.0 | 4.0 | 0.09464885379409815 | Destabilising | -0.33 | Destabilising | -0.05626598465473146 | 135 | 0.5133079847908745 | S | loop | -1.8666666666666665 | 3.61 | TYR | 0.947 | 0.303525641025641 | 1 | 1 | 0.59 | 1.183 | 3:1 | 146/150 | E:Y:H:F:Q:N:R:K:S:G:A:T:P:W:D | 69 | 0.7263157894736842 | 80 | effect | pnca_p.tyr64asp | 0.0002874802357337 | 1.57937329521209 | 4.85191414039982 | 0.114342297004304 | 1.0002536454007 | 1.57897279602454 | 0.581889091311512 | 40.4562911075298 | 4.85191417753471 | 0.685913110299906 | 4.85118443551178 | 0.137954936368295 | 0.860262754777729 | 0.351471331417763 | 67.0421060419706 | 1.17497090855698 | 0.278382201819561 | 0.17 | 0.0955056179775281 | Stabilising | ASP | 0 | pnca_complex.pdb |
| 162 | S65P | S | 65 | P | A | PZA | 8.267999999999999 | -0.032 | Destabilising | -0.499 | Destabilising | -0.0082687338501291 | -0.1263931104356636 | S65 | SA65 | 3.33753 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 4.0 | 0.0 | 4.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 4.0 | -4.0 | -2.0 | 0.0 | 0.0 | -2.0 | -2.0 | 0.12156010751826572 | Destabilising | -0.186 | Destabilising | -0.031713554987212275 | 97 | 0.6258064516129033 | S | loop | -0.9666666666666668 | 3.79 | SER | -0.697 | -0.5741350906095551 | 8 | 8 | -0.827 | -0.615 | 8:7 | 147/150 | L:V:R:K:I:E:Q:D:G:S:A:T | 21 | 0.22105263157894736 | 63 | effect | pnca_p.ser65pro | 0.0001437401178668 | -9.98752126245058 | 4.59700131334264e-05 | 0.942832958100734 | 139.277183325397 | -0.0717096729269463 | 144471.706314841 | 1.2119588062211 | 0.0834878586628579 | 0.0 | 1.0 | 0.0 | 0.0 | 25.8386585962163 | 1.0105682238915901e-25 | 0.999999999999746 | -0.19 | -0.0497382198952879 | Destabilising | PRO | 0 | pnca_complex.pdb | |
| 163 | S66L | S | 66 | L | A | PZA | 9.005 | 0.201 | Stabilising | -0.6629999999999999 | Destabilising | 0.1709183673469388 | -0.1679331306990881 | S66 | SA66 | 1.22464 | -10.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.0 | 0.0 | 0.0 | 4.0 | 0.0 | 0.0 | 0.0 | 0.0 | -1.0 | 0.0 | 0.0 | -5.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.044604054516714134 | Destabilising | 0.084 | Stabilising | 0.07094594594594596 | 71 | 0.4580645161290322 | S | loop | -0.8000000000000002 | 3.87 | SER | -0.098 | -0.08072487644151566 | 5 | 5 | -0.332 | -0.038 | 6:5 | 147/150 | N:V:I:R:H:F:E:Q:D:T:G:M:S:A | 32 | 0.3368421052631579 | 66 | effect | pnca_p.ser66leu | 0.0005030904125341 | -10.9879643775828 | 1.69039306948873e-05 | 0.928667766494711 | 122.741582014466 | -0.0895211239520097 | 1.02643587095793 | 0.346123821533658 | -0.460768509909571 | 0.0 | 0.611380301705926 | 0.213688558083325 | 0.0 | 3.36442927964707 | 0.489658927611485 | 0.484079488471969 | -0.57 | -0.1492146596858638 | Destabilising | LEU | 0 | pnca_complex.pdb | |
| 164 | S66P | S | 66 | P | A | PZA | 9.005 | -0.248 | Destabilising | -0.726 | Destabilising | -0.0640826873385013 | -0.1838905775075987 | S66 | SA66 | 1.91796 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 4.0 | 0.0 | 2.0 | 4.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.0 | 4.0 | -2.0 | -4.0 | 0.0 | 0.0 | -2.0 | 0.0 | 0.06985627809060381 | Destabilising | -0.165 | Destabilising | -0.02813299232736573 | 71 | 0.4580645161290322 | S | loop | -0.8000000000000002 | 3.87 | SER | -0.098 | -0.08072487644151566 | 5 | 5 | -0.332 | -0.038 | 6:5 | 147/150 | N:V:I:R:H:F:E:Q:D:T:G:M:S:A | 46 | 0.4842105263157895 | 71 | effect | pnca_p.ser66pro | 7.18700589334483e-05 | 12.1451538387261 | 188179.926264563 | 0.919026337424221 | 119.468044436209 | 0.101660271548273 | 5.01153666064915e-06 | 9.70142977291842 | 0.986835744238421 | inf | 0.170978870202674 | 0.767057556984365 | 0.124324963210678 | inf | 0.763784339928386 | 0.382146811758261 | -0.07 | -0.0183246073298429 | Destabilising | PRO | 0 | pnca_complex.pdb | |
| 165 | S67P | S | 67 | P | A | PZA | 8.658 | -0.228 | Destabilising | -1.699 | Destabilising | -0.0589147286821705 | -0.4303444782168186 | S67 | SA67 | 3.29311 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.0 | 0.0 | 2.0 | 4.0 | 0.0 | 0.0 | 0.0 | 0.0 | -2.0 | 2.0 | -2.0 | -4.0 | 0.0 | 0.0 | 0.0 | -4.0 | 0.11994223442769833 | Destabilising | -0.86 | Destabilising | -0.1466325660699062 | 15 | 0.0967741935483871 | - | loop | -0.8333333333333334 | 5.15 | SER | -0.355 | -0.29242174629324547 | 6 | 6 | -0.553 | -0.244 | 7:6 | 148/150 | N:L:V:I:F:Q:W:T:A:M:S:P | 40 | 0.42105263157894735 | 71 | effect | pnca_p.ser67pro | 0.0009343107661348 | 4.06858121107736 | 58.4739415306308 | 9.19336449861209e-05 | 1.04030498364652 | 3.91095041842055 | 11.5166635599536 | 1065.61332397634 | 58.4740177439797 | 1.76696293519342 | 58.4547574725378 | 6.68324361543955e-09 | 8.17501270782547 | 8.64086529870195 | 2465.74647273772 | 46.7514830195167 | 8.05839318437163e-12 | -0.0 | -0.0 | Stabilising | PRO | 0 | pnca_complex.pdb |
| 166 | S67L | S | 67 | L | A | PZA | 8.658 | 0.61 | Stabilising | -1.544 | Destabilising | 0.5187074829931972 | -0.3910840932117528 | S67 | SA67 | 0.0243891 | -8.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.0 | 0.0 | 0.0 | 4.0 | 0.0 | 0.0 | 0.0 | 0.0 | -5.0 | 0.0 | -2.0 | -5.0 | 0.0 | 0.0 | 0.0 | -2.0 | 0.0008883041106068664 | Destabilising | -0.207 | Destabilising | -0.03529411764705882 | 15 | 0.0967741935483871 | - | loop | -0.8333333333333334 | 5.15 | SER | -0.355 | -0.29242174629324547 | 6 | 6 | -0.553 | -0.244 | 7:6 | 148/150 | N:L:V:I:F:Q:W:T:A:M:S:P | 33 | 0.3473684210526316 | 66 | effect | 0.22 | 0.1235955056179775 | Stabilising | LEU | 0 | pnca_complex.pdb | ||||||||||||||||||
| 167 | S67W | S | 67 | W | A | PZA | 8.658 | -0.8320000000000001 | Destabilising | -0.833 | Destabilising | -0.2149870801033591 | -0.2109929078014184 | S67 | SA67 | 0.2013579999999999 | -10.0 | -4.0 | 0.0 | 0.0 | -4.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.0 | 0.0 | 0.0 | 0.0 | 0.0 | -4.0 | 0.0 | -4.0 | -4.0 | 0.0 | 0.0 | 0.0 | -6.0 | 0.007333896663000164 | Destabilising | -0.082 | Destabilising | -0.013981244671781756 | 15 | 0.0967741935483871 | - | loop | -0.8333333333333334 | 5.15 | SER | -0.355 | -0.29242174629324547 | 6 | 6 | -0.553 | -0.244 | 7:6 | 148/150 | N:L:V:I:F:Q:W:T:A:M:S:P | 39 | 0.4105263157894737 | 66 | effect | pnca_p.ser67trp | 7.18700589334483e-05 | 12.145153838726 | 188179.926264541 | 0.919026337424218 | 119.468044436204 | 0.101660271548276 | 5.01153666065335e-06 | 9.70142977291842 | 0.986835744238421 | inf | 0.170978870202674 | 0.767057556984365 | 0.124324963210678 | inf | 0.763784339928386 | 0.382146811758261 | -0.65 | -0.1701570680628272 | Destabilising | TRP | 0 | pnca_complex.pdb | |
| 168 | S67T | S | 67 | T | A | PZA | 8.658 | -0.129 | Destabilising | -1.3019999999999998 | Destabilising | -0.0333333333333333 | -0.3297872340425531 | S67 | SA67 | -0.265321 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -8.0 | 0.0 | -6.0 | -2.0 | 0.0 | 0.0 | 0.0 | -4.0 | -0.051011497346766126 | Stabilising | -0.27 | Destabilising | -0.04603580562659847 | 15 | 0.0967741935483871 | - | loop | -0.8333333333333334 | 5.15 | SER | -0.355 | -0.29242174629324547 | 6 | 6 | -0.553 | -0.244 | 7:6 | 148/150 | N:L:V:I:F:Q:W:T:A:M:S:P | -47 | -0.5053763440860215 | 72 | neutral | -0.1 | -0.0261780104712041 | Destabilising | THR | 0 | pnca_complex.pdb | ||||||||||||||||||
| 169 | W68C | W | 68 | C | A | PZA | 4.974 | -1.453 | Destabilising | -1.575 | Destabilising | -0.3754521963824289 | -0.3989361702127659 | W68 | WA68 | 2.68091 | 46.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 4.0 | 0.0 | 0.0 | 4.0 | 2.0 | 0.0 | 0.0 | 4.0 | 0.09764457783054946 | Destabilising | -1.561 | Destabilising | -0.26615515771526 | 45 | 0.1578947368421052 | B | strand | -1.1 | 5.49 | TRP | -1.146 | -0.943986820428336 | 9 | 9 | -1.221 | -1.124 | 9:9 | 150/150 | F:W | 78 | 0.8210526315789474 | 85 | effect | pnca_p.trp68cys | 0.0004312203536006 | 3.19016080361872 | 24.2923334241599 | 0.0035954281300595 | 1.09565968954934 | 2.91163472932995 | 3.91551977432164 | 465.531063220521 | 24.2923336141533 | 1.38546923679232 | 24.2833096922897 | 0.0007494070007895 | 3.12528225414311 | 2.71567844828345 | 1141.60089496884 | 14.1977442691074 | 0.0001645676755807 | -1.46 | -0.3821989528795811 | Destabilising | CYS | 0 | pnca_complex.pdb |
| 170 | W68G | W | 68 | G | A | PZA | 4.974 | -2.572 | Destabilising | -2.125 | Destabilising | -0.6645994832041343 | -0.5382472137791287 | W68 | WA68 | 4.03792 | 52.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 4.0 | 0.0 | 0.0 | 4.0 | 4.0 | 0.0 | 5.0 | 21.0 | 0.14706983588167163 | Destabilising | -1.882 | Destabilising | -0.3208866155157715 | 45 | 0.1578947368421052 | B | strand | -1.1 | 5.49 | TRP | -1.146 | -0.943986820428336 | 9 | 9 | -1.221 | -1.124 | 9:9 | 150/150 | F:W | 86 | 0.9052631578947369 | 91 | effect | pnca_p.trp68gly | 0.0013655311197355 | 4.47658569248055 | 87.9339260820995 | 1.32290566590749e-05 | 1.02761623592683 | 4.35628159226488 | 18.1565285172187 | 1582.53238090538 | 87.9339263024142 | 1.94415646509946 | 87.8998400324811 | 2.3565519928076e-13 | 12.6277229739224 | 13.8702072448497 | 3588.35734387119 | 75.5173867602406 | 3.62203368500016e-18 | -3.08 | -0.8062827225130891 | Destabilising | GLY | 0 | pnca_complex.pdb |
| 171 | W68R | W | 68 | R | A | PZA | 4.974 | -1.608 | Destabilising | -0.5760000000000001 | Destabilising | -0.4155038759689922 | -0.1458966565349544 | W68 | WA68 | 0.0790982 | -18.0 | -32.0 | 0.0 | 0.0 | -32.0 | 0.0 | 0.0 | 0.0 | 0.0 | -2.0 | 0.0 | -2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -1.0 | 0.0 | -4.0 | 3.0 | 2.0 | 0.0 | 0.0 | -2.0 | 0.0028809286198180346 | Destabilising | -1.263 | Destabilising | -0.21534526854219946 | 45 | 0.1578947368421052 | B | strand | -1.1 | 5.49 | TRP | -1.146 | -0.943986820428336 | 9 | 9 | -1.221 | -1.124 | 9:9 | 150/150 | F:W | 89 | 0.9368421052631579 | 91 | effect | pnca_p.trp68arg | 0.0020123616501365 | 4.88586941655608 | 132.40553086776 | 1.59295080619135e-06 | 1.01805765099734 | 4.79920701128237 | 28.2126225203342 | 2362.8544732838 | 132.405612244898 | 2.12190639382976 | 132.608758225219 | 4.03470202806197e-20 | 19.3941885333947 | 21.793565475171 | 5246.53379470447 | 119.023328875182 | 1.03505008297772e-27 | -1.5 | -0.3926701570680628 | Destabilising | ARG | 0 | pnca_complex.pdb |
| 172 | W68S | W | 68 | S | A | PZA | 4.974 | -2.673 | Destabilising | -1.036 | Destabilising | -0.6906976744186046 | -0.2624113475177305 | W68 | WA68 | 2.64788 | 48.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -2.0 | 0.0 | -2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 4.0 | 0.0 | 2.0 | 4.0 | 0.09644155333299338 | Destabilising | -1.343 | Destabilising | -0.22898550724637678 | 45 | 0.1578947368421052 | B | strand | -1.1 | 5.49 | TRP | -1.146 | -0.943986820428336 | 9 | 9 | -1.221 | -1.124 | 9:9 | 150/150 | F:W | 86 | 0.9052631578947369 | 91 | effect | pnca_p.trp68ser | 7.18700589334483e-05 | 12.1451538387252 | 188179.926264399 | 0.919026337424192 | 119.468044436157 | 0.101660271548309 | 5.01153666069715e-06 | 9.70142977291842 | 0.986835744238421 | inf | 0.170978870202674 | 0.767057556984365 | 0.124324963210678 | inf | 0.763784339928386 | 0.382146811758261 | -3.09 | -0.8089005235602095 | Destabilising | SER | 0 | pnca_complex.pdb | |
| 173 | W68L | W | 68 | L | A | PZA | 4.974 | -1.622 | Destabilising | -2.242 | Destabilising | -0.4191214470284237 | -0.5678824721377913 | W68 | WA68 | 0.192132 | 30.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -3.0 | 0.0 | -1.0 | -3.0 | 0.0 | 0.0 | 0.0 | 2.0 | 0.006997865660443331 | Destabilising | -1.096 | Destabilising | -0.18687127024722933 | 45 | 0.1578947368421052 | B | strand | -1.1 | 5.49 | TRP | -1.146 | -0.943986820428336 | 9 | 9 | -1.221 | -1.124 | 9:9 | 150/150 | F:W | 84 | 0.8842105263157894 | 91 | effect | -1.35 | -0.3534031413612565 | Destabilising | LEU | 0 | pnca_complex.pdb | ||||||||||||||||||
| 174 | P69R | P | 69 | R | A | PZA | 7.994 | -1.258 | Destabilising | -0.966 | Destabilising | -0.3250645994832041 | -0.2446808510638297 | P69 | PA69 | 2.33826 | -46.0 | -14.0 | 0.0 | 0.0 | -14.0 | 0.0 | 0.0 | 0.0 | 0.0 | -2.0 | 0.0 | -2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -8.0 | 0.0 | -2.0 | -7.0 | -6.0 | 0.0 | 0.0 | -2.0 | 0.08516451897231186 | Destabilising | -1.319 | Destabilising | -0.2248934356351236 | 23 | 0.1446540880503144 | - | loop | -1.3666666666666665 | 4.65 | PRO | -1.198 | -0.9868204283360791 | 9 | 9 | -1.229 | -1.178 | 9:9 | 150/150 | P | 77 | 0.8105263157894737 | 85 | effect | pnca_p.pro69arg | 7.18700589334483e-05 | -8.98740878149642 | 0.0001249735077034 | 0.940032862253634 | 119.468044435493 | -0.0752285585987743 | 4692673.51081303 | 2.42412778478352 | 0.384555509373631 | 0.0 | 1.0 | 0.0 | 0.0 | 188.544222231268 | 1.0341007080334399e-29 | 0.999999999999997 | -1.24 | -0.3246073298429319 | Destabilising | ARG | 0 | pnca_complex.pdb | |
| 175 | P69Q | P | 69 | Q | A | PZA | 7.994 | -1.59 | Destabilising | -0.293 | Destabilising | -0.4108527131782946 | -0.0742147922998986 | P69 | PA69 | 2.83344 | -12.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -2.0 | 0.0 | -2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -6.0 | 0.0 | -2.0 | -5.0 | -8.0 | 0.0 | -2.0 | -2.0 | 0.1032000524479345 | Destabilising | -1.339 | Destabilising | -0.22830349531116792 | 23 | 0.1446540880503144 | - | loop | -1.3666666666666665 | 4.65 | PRO | -1.198 | -0.9868204283360791 | 9 | 9 | -1.229 | -1.178 | 9:9 | 150/150 | P | 71 | 0.7473684210526316 | 85 | effect | pnca_p.pro69gln | 7.18700589334483e-05 | -8.98740878149641 | 0.0001249735077034 | 0.940032862253634 | 119.468044435492 | -0.0752285585987744 | 4692673.51081431 | 2.42412778478352 | 0.384555509373631 | 0.0 | 1.0 | 0.0 | 0.0 | 188.544222231268 | 1.0341007080334399e-29 | 0.999999999999997 | -0.94 | -0.2460732984293193 | Destabilising | GLN | 0 | pnca_complex.pdb | |
| 176 | P69L | P | 69 | L | A | PZA | 7.994 | 0.046 | Stabilising | -1.774 | Destabilising | 0.0391156462585034 | -0.4493414387031408 | P69 | PA69 | 2.773 | -12.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -1.0 | 0.0 | -1.0 | 0.0 | -4.0 | 0.0 | -2.0 | 0.0 | 0.1009986960860729 | Destabilising | -1.421 | Destabilising | -0.2422847399829497 | 23 | 0.1446540880503144 | - | loop | -1.3666666666666665 | 4.65 | PRO | -1.198 | -0.9868204283360791 | 9 | 9 | -1.229 | -1.178 | 9:9 | 150/150 | P | 71 | 0.7473684210526316 | 85 | effect | pnca_p.pro69leu | 0.0004312203536006 | 3.19016080361873 | 24.2923334241601 | 0.0035954281300594 | 1.09565968954934 | 2.91163472932996 | 3.91551977432241 | 465.531063220338 | 24.2923336141533 | 1.38546923679232 | 24.2833096922897 | 0.0007494070007895 | 3.12528225414311 | 2.71567844828345 | 1141.60089496884 | 14.1977442691074 | 0.0001645676755807 | -0.28 | -0.0732984293193717 | Destabilising | LEU | 0 | pnca_complex.pdb |
| 177 | P69S | P | 69 | S | A | PZA | 7.994 | -2.477 | Destabilising | -0.353 | Destabilising | -0.6400516795865633 | -0.0894123606889564 | P69 | PA69 | 3.28838 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -2.0 | 0.0 | 0.0 | 0.0 | 0.0 | -1.0 | 0.0 | -1.0 | 0.0 | 2.0 | 0.0 | 2.0 | 2.0 | 0.11976995753174192 | Destabilising | -1.447 | Destabilising | -0.24671781756180733 | 23 | 0.1446540880503144 | - | loop | -1.3666666666666665 | 4.65 | PRO | -1.198 | -0.9868204283360791 | 9 | 9 | -1.229 | -1.178 | 9:9 | 150/150 | P | 73 | 0.7684210526315789 | 85 | effect | pnca_p.pro69ser | 0.0001437401178668 | -9.98752126245059 | 4.59700131334263e-05 | 0.942832958100734 | 139.277183325398 | -0.0717096729269462 | 144471.706314845 | 1.2119588062211 | 0.0834878586628579 | 0.0 | 1.0 | 0.0 | 0.0 | 25.8386585962163 | 1.0105682238915901e-25 | 0.999999999999746 | -1.93 | -0.5052356020942408 | Destabilising | SER | 0 | pnca_complex.pdb | |
| 178 | P69T | P | 69 | T | A | PZA | 7.994 | -1.905 | Destabilising | -0.377 | Destabilising | -0.4922480620155038 | -0.0954913880445795 | P69 | PA69 | 2.7518700000000003 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -2.0 | 0.0 | -2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -1.0 | 0.0 | -1.0 | 0.0 | 0.0 | 0.0 | 2.0 | 0.0 | 0.10022909549166298 | Destabilising | -1.735 | Destabilising | -0.2958226768968457 | 23 | 0.1446540880503144 | - | loop | -1.3666666666666665 | 4.65 | PRO | -1.198 | -0.9868204283360791 | 9 | 9 | -1.229 | -1.178 | 9:9 | 150/150 | P | 72 | 0.7578947368421053 | 85 | effect | pnca_p.pro69thr | 7.18700589334483e-05 | 12.1451538387252 | 188179.926264408 | 0.919026337424193 | 119.46804443616 | 0.101660271548307 | 5.01153666069443e-06 | 9.70142977291842 | 0.986835744238421 | inf | 0.170978870202674 | 0.767057556984365 | 0.124324963210678 | inf | 0.763784339928386 | 0.382146811758261 | -1.08 | -0.2827225130890052 | Destabilising | THR | 0 | pnca_complex.pdb | |
| 179 | H71Y | H | 71 | Y | A | PZA | 4.184 | -0.461 | Destabilising | -1.955 | Destabilising | -0.1191214470284237 | -0.4951874366767984 | H71 | HA71 | -1.77532 | -26.0 | -6.0 | 0.0 | 0.0 | -6.0 | 0.0 | 0.0 | 0.0 | 0.0 | -2.0 | 0.0 | 2.0 | -4.0 | 0.0 | 0.0 | 0.0 | 0.0 | -8.0 | 0.0 | -3.0 | -5.0 | -12.0 | 0.0 | -12.0 | -6.0 | -0.34132892409443977 | Stabilising | -0.84 | Destabilising | -0.1432225063938619 | 5 | 0.0223214285714285 | - | loop | -0.7666666666666667 | 6.25 | HIS | -1.209 | -0.9958813838550248 | 9 | 9 | -1.229 | -1.201 | 9:9 | 150/150 | H | 61 | 0.6421052631578947 | 80 | effect | pnca_p.his71tyr | 0.0017967514733362 | 3.24545333052325 | 25.6733459339263 | 2.7826871320661e-09 | 0.546011377839736 | 5.94392985612077 | 9.76352440503871 | 88.06998811648 | 25.6733460559796 | 1.40948247478545 | 25.6638623299459 | 4.51976315688199e-13 | 12.3448843223466 | 8.64707452935555 | 102.96388402837 | 74.4270249019608 | 6.2921718497543394e-18 | -0.23 | -0.0602094240837696 | Destabilising | TYR | 0 | pnca_complex.pdb |
| 180 | H71R | H | 71 | R | A | PZA | 4.184 | -1.93 | Destabilising | -0.831 | Destabilising | -0.4987080103359173 | -0.2104863221884498 | H71 | HA71 | -1.52387 | -36.0 | -2.0 | 0.0 | 0.0 | -2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.0 | -2.0 | 0.0 | 0.0 | 0.0 | 0.0 | -1.0 | 0.0 | -1.0 | 1.0 | -4.0 | 0.0 | -4.0 | 0.0 | -0.29298431131277397 | Stabilising | -1.26 | Destabilising | -0.21483375959079284 | 5 | 0.0223214285714285 | - | loop | -0.7666666666666667 | 6.25 | HIS | -1.209 | -0.9958813838550248 | 9 | 9 | -1.229 | -1.201 | 9:9 | 150/150 | H | 77 | 0.8105263157894737 | 85 | effect | pnca_p.his71arg | 0.0005030904125341 | 0.662825392344309 | 1.94026661170037 | 0.428026066477985 | 0.836294653807202 | 0.792573992105318 | 0.27776402289494 | 9.00753289954653 | 1.94026083298275 | 0.287860116894481 | 1.94003614333864 | 0.342335895194644 | 0.465547561079344 | 0.184637933513187 | 11.8604663966297 | 0.0926662555126122 | 0.760814539944039 | -1.58 | -0.4136125654450262 | Destabilising | ARG | 0 | pnca_complex.pdb |
| 181 | H71P | H | 71 | P | A | PZA | 4.184 | -2.362 | Destabilising | -2.885 | Destabilising | -0.6103359173126615 | -0.7307497467071935 | H71 | HA71 | 3.26218 | 32.0 | 8.0 | 0.0 | 0.0 | 8.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.0 | 0.0 | 2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -2.0 | 0.0 | -4.0 | 2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.11881569650128569 | Destabilising | -1.555 | Destabilising | -0.2651321398124467 | 5 | 0.0223214285714285 | - | loop | -0.7666666666666667 | 6.25 | HIS | -1.209 | -0.9958813838550248 | 9 | 9 | -1.229 | -1.201 | 9:9 | 150/150 | H | 84 | 0.8842105263157894 | 91 | effect | pnca_p.his71pro | 0.0001437401178668 | 1.57903938912402 | 4.85029432717734 | 0.264247566376723 | 1.41439286276584 | 1.11640791656443 | 0.191756076673778 | 122.683760399245 | 4.85029436501262 | 0.685768096792206 | 4.84956447904112 | 0.312734154310187 | 0.504824686014995 | 0.061763864579114 | 379.558337204203 | 0.0881192621863332 | 0.766581879696361 | -2.44 | -0.6387434554973822 | Destabilising | PRO | 0 | pnca_complex.pdb |
| 182 | H71D | H | 71 | D | A | PZA | 4.184 | -2.685 | Destabilising | -2.498 | Destabilising | -0.6937984496124031 | -0.6327254305977711 | H71 | HA71 | 5.74525 | 18.0 | -24.0 | 0.0 | 0.0 | -24.0 | 0.0 | 0.0 | 0.0 | 0.0 | 4.0 | 0.0 | 2.0 | 2.0 | 0.0 | 0.0 | 0.0 | 0.0 | -3.0 | 0.0 | -7.0 | 4.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.20925451088658864 | Destabilising | -1.66 | Destabilising | -0.2830349531116794 | 5 | 0.0223214285714285 | - | loop | -0.7666666666666667 | 6.25 | HIS | -1.209 | -0.9958813838550248 | 9 | 9 | -1.229 | -1.201 | 9:9 | 150/150 | H | 82 | 0.8631578947368421 | 91 | effect | pnca_p.his71asp | 7.18700589334483e-05 | 12.1451538387264 | 188179.926264626 | 0.919026337424233 | 119.468044436231 | 0.101660271548257 | 5.01153666062825e-06 | 9.70142977291842 | 0.986835744238421 | inf | 0.170978870202674 | 0.767057556984365 | 0.124324963210678 | inf | 0.763784339928386 | 0.382146811758261 | -2.6 | -0.680628272251309 | Destabilising | ASP | 0 | pnca_complex.pdb | |
| 183 | H71Q | H | 71 | Q | A | PZA | 4.184 | -2.294 | Destabilising | -1.733 | Destabilising | -0.592764857881137 | -0.4389564336372847 | H71 | HA71 | 1.12335 | -4.0 | 6.0 | 0.0 | 0.0 | 6.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.0 | -2.0 | 0.0 | 0.0 | 0.0 | 0.0 | -5.0 | 0.0 | -5.0 | -1.0 | 0.0 | 0.0 | 0.0 | 2.0 | 0.04091485223522899 | Destabilising | -1.091 | Destabilising | -0.18601875532821824 | 5 | 0.0223214285714285 | - | loop | -0.7666666666666667 | 6.25 | HIS | -1.209 | -0.9958813838550248 | 9 | 9 | -1.229 | -1.201 | 9:9 | 150/150 | H | 67 | 0.7052631578947368 | 80 | effect | pnca_p.his71gln | 0.0001437401178668 | 13.1456002256222 | 511754.463553472 | 0.924803768447052 | 139.277183326685 | 0.0943844491368574 | 0.0001628371344425 | 19.411022297013 | 1.28804840845689 | inf | 0.0292235860951597 | 1.53426649183163 | 0.91081598550184 | inf | 4.73122070382274 | 0.0296198560706035 | -1.86 | -0.486910994764398 | Destabilising | GLN | 0 | pnca_complex.pdb | |
| 184 | H71N | H | 71 | N | A | PZA | 4.184 | -2.6710000000000003 | Destabilising | -1.335 | Destabilising | -0.6901808785529716 | -0.3381458966565349 | H71 | HA71 | 0.64378 | 16.0 | 6.0 | 0.0 | 0.0 | 6.0 | 0.0 | 0.0 | 0.0 | 0.0 | -2.0 | 0.0 | 2.0 | -4.0 | 0.0 | 0.0 | 0.0 | 0.0 | 1.0 | 0.0 | -2.0 | 5.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.023447868938439236 | Destabilising | -1.764 | Destabilising | -0.30076726342710997 | 5 | 0.0223214285714285 | - | loop | -0.7666666666666667 | 6.25 | HIS | -1.209 | -0.9958813838550248 | 9 | 9 | -1.229 | -1.201 | 9:9 | 150/150 | H | 70 | 0.7368421052631579 | 85 | effect | -2.6 | -0.680628272251309 | Destabilising | ASN | 0 | pnca_complex.pdb | ||||||||||||||||||
| 185 | C72W | C | 72 | W | A | PZA | 7.053 | -1.725 | Destabilising | 0.265 | Stabilising | -0.4457364341085271 | 0.1188340807174888 | C72 | CA72 | 27.4558 | -46.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -2.0 | 0.0 | 0.0 | -2.0 | 0.0 | 0.0 | 0.0 | 0.0 | -12.0 | 0.0 | -12.0 | -6.0 | -16.0 | 0.0 | -14.0 | -8.0 | 1.0 | Destabilising | -1.622 | Destabilising | -0.2765558397271952 | 0 | 0.0 | S | loop | 1.1666666666666667 | 7.01 | CYS | -1.104 | -0.9093904448105438 | 9 | 9 | -1.178 | -1.062 | 9:9 | 150/150 | G:A:C | 85 | 0.8947368421052632 | 91 | effect | pnca_p.cys72trp | 0.0001437401178668 | 13.14560022562 | 511754.463552333 | 0.924803768446981 | 139.277183326528 | 0.0943844491369478 | 0.0001628371344461 | 19.411022297013 | 1.28804840845689 | inf | 0.0292235860951597 | 1.53426649183163 | 0.91081598550184 | inf | 4.73122070382274 | 0.0296198560706035 | -1.13 | -0.2958115183246073 | Destabilising | TRP | 0 | pnca_complex.pdb | |
| 186 | C72R | C | 72 | R | A | PZA | 7.053 | -1.639 | Destabilising | 0.152 | Stabilising | -0.4235142118863049 | 0.0681614349775784 | C72 | CA72 | 7.93343 | -68.0 | -32.0 | 0.0 | 0.0 | -32.0 | 0.0 | 0.0 | 0.0 | 0.0 | -6.0 | 0.0 | -6.0 | -2.0 | 0.0 | 0.0 | 0.0 | 0.0 | -16.0 | 0.0 | -5.0 | -13.0 | -20.0 | 0.0 | -8.0 | -12.0 | 0.28895278957451614 | Destabilising | -2.368 | Destabilising | -0.4037510656436487 | 0 | 0.0 | S | loop | 1.1666666666666667 | 7.01 | CYS | -1.104 | -0.9093904448105438 | 9 | 9 | -1.178 | -1.062 | 9:9 | 150/150 | G:A:C | 87 | 0.9157894736842105 | 91 | effect | pnca_p.cys72arg | 0.0002156101768003 | 2.27260607808817 | 9.70465898653054 | 0.0634455902260893 | 1.22442760158496 | 1.8560559033024 | 0.929172866365108 | 208.881603005161 | 9.70466975178797 | 0.986980761010679 | 9.70194990589383 | 0.0776844925942494 | 1.10966566656461 | 0.504888890842109 | 570.372842410328 | 2.29168245016684 | 0.130068862702538 | -1.28 | -0.3350785340314136 | Destabilising | ARG | 0 | pnca_complex.pdb |
| 187 | C72Y | C | 72 | Y | A | PZA | 7.053 | -1.564 | Destabilising | 0.154 | Stabilising | -0.4041343669250646 | 0.0690582959641255 | C72 | CA72 | 15.4245 | -46.0 | -12.0 | 0.0 | 0.0 | -12.0 | 0.0 | 0.0 | 0.0 | 0.0 | -2.0 | 0.0 | -2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -15.0 | 0.0 | -4.0 | -13.0 | -18.0 | 0.0 | -16.0 | -14.0 | 0.5617938650485508 | Destabilising | -1.249 | Destabilising | -0.21295822676896847 | 0 | 0.0 | S | loop | 1.1666666666666667 | 7.01 | CYS | -1.104 | -0.9093904448105438 | 9 | 9 | -1.178 | -1.062 | 9:9 | 150/150 | G:A:C | 83 | 0.8736842105263158 | 91 | effect | pnca_p.cys72tyr | 7.18700589334483e-05 | 12.1451538387253 | 188179.92626441 | 0.919026337424193 | 119.46804443616 | 0.101660271548307 | 5.0115366606943e-06 | 9.70142977291842 | 0.986835744238421 | inf | 0.170978870202674 | 0.767057556984365 | 0.124324963210678 | inf | 0.763784339928386 | 0.382146811758261 | -1.05 | -0.274869109947644 | Destabilising | TYR | 0 | pnca_complex.pdb | |
| 188 | C72G | C | 72 | G | A | PZA | 7.053 | -1.759 | Destabilising | -0.725 | Destabilising | -0.4545219638242894 | -0.1836372847011144 | C72 | CA72 | 1.3326 | 10.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -2.0 | 0.0 | 0.0 | -2.0 | 0.0 | 0.0 | 3.0 | 17.0 | 0.04853619271702154 | Destabilising | -1.459 | Destabilising | -0.24876385336743392 | 0 | 0.0 | S | loop | 1.1666666666666667 | 7.01 | CYS | -1.104 | -0.9093904448105438 | 9 | 9 | -1.178 | -1.062 | 9:9 | 150/150 | G:A:C | 54 | 0.5684210526315789 | 75 | effect | -1.55 | -0.4057591623036649 | Destabilising | GLY | 0 | pnca_complex.pdb | ||||||||||||||||||
| 189 | V73D | V | 73 | D | A | PZA | 10.768 | -1.148 | Destabilising | 1.153 | Stabilising | -0.296640826873385 | 0.5170403587443946 | V73 | VA73 | 1.11169 | -6.0 | -50.0 | 0.0 | 0.0 | -50.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -2.0 | 0.0 | -4.0 | 2.0 | 2.0 | 0.0 | 2.0 | -2.0 | 0.04049016965449923 | Destabilising | -2.613 | Destabilising | -0.4455242966751918 | 46 | 0.264367816091954 | B | strand | 1.9666666666666668 | 4.66 | VAL | -0.743 | -0.6120263591433278 | 8 | 8 | -0.872 | -0.674 | 8:7 | 150/150 | I:R:K:L:V:E:T:M | 87 | 0.9157894736842105 | 91 | effect | -1.37 | -0.3586387434554974 | Destabilising | ASP | 0 | pnca_complex.pdb | ||||||||||||||||||
| 190 | T76P | T | 76 | P | A | PZA | 14.032 | -0.519 | Destabilising | -0.382 | Destabilising | -0.1341085271317829 | -0.096757852077001 | T76 | TA76 | 1.15155 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.0 | 0.0 | 2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -4.0 | 2.0 | -6.0 | -2.0 | 4.0 | 0.0 | 2.0 | 0.0 | 0.04194195761915515 | Destabilising | -1.623 | Destabilising | -0.27672634271099744 | 56 | 0.3255813953488372 | S | loop | -0.9 | 3.94 | THR | -0.548 | -0.45140032948929165 | 7 | 7 | -0.674 | -0.485 | 7:7 | 150/150 | Q:T:S:D | 78 | 0.8210526315789474 | 85 | effect | pnca_p.thr76pro | 0.0017248814144027 | 3.19623916718558 | 24.4404407276145 | 5.521534264615841e-09 | 0.548179859875324 | 5.83063954212496 | 9.23910743126347 | 84.0861153416749 | 24.4404408647732 | 1.38810903558899 | 24.4312693653994 | 2.2395302438185697e-12 | 11.6498430682339 | 8.17279939949528 | 98.407580019827 | 69.8031277140286 | 6.55288933297668e-17 | -0.09 | -0.0235602094240837 | Destabilising | PRO | 0 | pnca_complex.pdb |
| 191 | T76I | T | 76 | I | A | PZA | 14.032 | 0.311 | Stabilising | -0.319 | Destabilising | 0.2644557823129251 | -0.0808004052684903 | T76 | TA76 | -0.781308 | -10.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.0 | 0.0 | 2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -6.0 | 0.0 | -6.0 | 0.0 | 0.0 | 0.0 | 0.0 | -4.0 | -0.15021687302930092 | Stabilising | -0.733 | Destabilising | -0.12497868712702472 | 56 | 0.3255813953488372 | S | loop | -0.9 | 3.94 | THR | -0.548 | -0.45140032948929165 | 7 | 7 | -0.674 | -0.485 | 7:7 | 150/150 | Q:T:S:D | 69 | 0.7263157894736842 | 80 | effect | pnca_p.thr76ile | 0.0002156101768003 | 13.1460210125007 | 511969.848429101 | 0.907969111549626 | 113.719344731963 | 0.115600569485217 | 0.183926936276972 | 29.1287878787879 | 1.4643224129316 | inf | 0.0049931328456149 | 2.3016268790981 | 2.00455510251839 | inf | 9.2872640727157 | 0.0023075254069185 | -0.73 | -0.1910994764397905 | Destabilising | ILE | 0 | pnca_complex.pdb | |
| 192 | P77L | P | 77 | L | A | PZA | 13.235 | 0.544 | Stabilising | 0.067 | Stabilising | 0.4625850340136055 | 0.0300448430493273 | P77 | PA77 | 0.65747 | -10.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -5.0 | -2.0 | -3.0 | -1.0 | 0.0 | 0.0 | 0.0 | -2.0 | 0.023946488537940982 | Destabilising | -0.447 | Destabilising | -0.07621483375959079 | 94 | 0.5911949685534591 | G | helix | -0.9 | 3.75 | PRO | 3.113 | 0.9977564102564103 | 1 | 1 | 1.712 | 3.125 | 1:1 | 150/150 | T:W:Q:E:F:R:L:V:N:P:G:S:A:D:Y:H:K | 18 | 0.18947368421052632 | 59 | effect | pnca_p.pro77leu | 7.18700589334483e-05 | -8.98740878149639 | 0.0001249735077034 | 0.940032862253632 | 119.468044435489 | -0.075228558598776 | 4692673.51081001 | 2.42412778478352 | 0.384555509373631 | 0.0 | 1.0 | 0.0 | 0.0 | 188.544222231268 | 1.0341007080334399e-29 | 0.999999999999997 | -0.2 | -0.0523560209424083 | Destabilising | LEU | 0 | pnca_complex.pdb | |
| 193 | G78A | G | 78 | A | A | PZA | 9.84 | 0.335 | Stabilising | -0.912 | Destabilising | 0.2848639455782313 | -0.2310030395136778 | G78 | GA78 | 1.30582 | -4.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -2.0 | 0.0 | 0.0 | -2.0 | -2.0 | 0.0 | -7.0 | -16.0 | 0.04756080682405903 | Destabilising | -1.378 | Destabilising | -0.23495311167945437 | 8 | 0.0769230769230769 | G | helix | -0.0666666666666667 | 4.83 | GLY | -0.882 | -0.7265238879736409 | 8 | 8 | -0.993 | -0.827 | 9:8 | 150/150 | G:E:N:D | 67 | 0.7052631578947368 | 80 | effect | -0.01 | -0.0026178010471204 | Destabilising | ALA | 0 | pnca_complex.pdb | ||||||||||||||||||
| 194 | G78C | G | 78 | C | A | PZA | 9.84 | -1.038 | Destabilising | -0.281 | Destabilising | -0.2682170542635659 | -0.0711752786220871 | G78 | GA78 | 2.40156 | -10.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -2.0 | 0.0 | -2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -5.0 | 0.0 | -1.0 | -4.0 | -4.0 | 0.0 | -9.0 | -19.0 | 0.08747004275963548 | Destabilising | -1.186 | Destabilising | -0.2022165387894288 | 8 | 0.0769230769230769 | G | helix | -0.0666666666666667 | 4.83 | GLY | -0.882 | -0.7265238879736409 | 8 | 8 | -0.993 | -0.827 | 9:8 | 150/150 | G:E:N:D | 70 | 0.7368421052631579 | 85 | effect | pnca_p.gly78cys | 0.0002156101768003 | 2.27260607808816 | 9.70465898653048 | 0.0634455902260901 | 1.22442760158496 | 1.8560559033024 | 0.929172866365334 | 208.881603004981 | 9.70466975178797 | 0.986980761010679 | 9.70194990589383 | 0.0776844925942494 | 1.10966566656461 | 0.504888890842109 | 570.372842410328 | 2.29168245016684 | 0.130068862702538 | -0.68 | -0.1780104712041885 | Destabilising | CYS | 0 | pnca_complex.pdb |
| 195 | G78V | G | 78 | V | A | PZA | 9.84 | 0.114 | Stabilising | -0.8420000000000001 | Destabilising | 0.096938775510204 | -0.2132725430597771 | G78 | GA78 | 2.8237 | -8.0 | -2.0 | 0.0 | 0.0 | -2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.0 | 0.0 | 2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -17.0 | 0.0 | -11.0 | -10.0 | -8.0 | 0.0 | -9.0 | -21.0 | 0.10284530044653589 | Destabilising | -1.939 | Destabilising | -0.33060528559249786 | 8 | 0.0769230769230769 | G | helix | -0.0666666666666667 | 4.83 | GLY | -0.882 | -0.7265238879736409 | 8 | 8 | -0.993 | -0.827 | 9:8 | 150/150 | G:E:N:D | 77 | 0.8105263157894737 | 85 | effect | pnca_p.gly78val | 0.0001437401178668 | 13.1456002256219 | 511754.463553282 | 0.924803768447042 | 139.277183326662 | 0.0943844491368702 | 0.0001628371344429 | 19.411022297013 | 1.28804840845689 | inf | 0.0292235860951597 | 1.53426649183163 | 0.91081598550184 | inf | 4.73122070382274 | 0.0296198560706035 | -0.82 | -0.2146596858638743 | Destabilising | VAL | 0 | pnca_complex.pdb | |
| 196 | G78R | G | 78 | R | A | PZA | 9.84 | -0.272 | Destabilising | -0.84 | Destabilising | -0.0702842377260982 | -0.2127659574468085 | G78 | GA78 | 1.06499 | -42.0 | -20.0 | 0.0 | 0.0 | -20.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.0 | -4.0 | 0.0 | 0.0 | 0.0 | 0.0 | -9.0 | 0.0 | -5.0 | -7.0 | -6.0 | 0.0 | -11.0 | -13.0 | 0.03878925400097612 | Destabilising | -1.34 | Destabilising | -0.22847399829497017 | 8 | 0.0769230769230769 | G | helix | -0.0666666666666667 | 4.83 | GLY | -0.882 | -0.7265238879736409 | 8 | 8 | -0.993 | -0.827 | 9:8 | 150/150 | G:E:N:D | 84 | 0.8842105263157894 | 91 | effect | -0.13 | -0.0340314136125654 | Destabilising | ARG | 0 | pnca_complex.pdb | ||||||||||||||||||
| 197 | G78S | G | 78 | S | A | PZA | 9.84 | -0.8590000000000001 | Destabilising | 0.215 | Stabilising | -0.2219638242894057 | 0.0964125560538116 | G78 | GA78 | 0.982763 | -6.0 | -2.0 | 0.0 | 0.0 | -2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.0 | -2.0 | 0.0 | 0.0 | 0.0 | 0.0 | -10.0 | 0.0 | -8.0 | -2.0 | -2.0 | 0.0 | -5.0 | -19.0 | 0.035794367674589704 | Destabilising | -1.528 | Destabilising | -0.26052855924978685 | 8 | 0.0769230769230769 | G | helix | -0.0666666666666667 | 4.83 | GLY | -0.882 | -0.7265238879736409 | 8 | 8 | -0.993 | -0.827 | 9:8 | 150/150 | G:E:N:D | 65 | 0.6842105263157895 | 80 | effect | pnca_p.gly78ser | 0.0002156101768003 | 2.27260607808817 | 9.7046589865305 | 0.0634455902260898 | 1.22442760158496 | 1.8560559033024 | 0.929172866365337 | 208.881603004981 | 9.70466975178797 | 0.986980761010679 | 9.70194990589383 | 0.0776844925942494 | 1.10966566656461 | 0.504888890842109 | 570.372842410328 | 2.29168245016684 | 0.130068862702538 | -0.4 | -0.1047120418848167 | Destabilising | SER | 0 | pnca_complex.pdb |
| 198 | A79T | A | 79 | T | A | PZA | 10.663 | -1.881 | Destabilising | -0.176 | Destabilising | -0.4860465116279069 | -0.044579533941236 | A79 | AA79 | -0.0668707 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -2.0 | 0.0 | -2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -1.0 | 0.0 | -1.0 | 0.0 | -2.0 | 0.0 | -2.0 | -5.0 | -0.01285678305006537 | Stabilising | -2.659 | Destabilising | -0.4533674339300937 | 1 | 0.0077519379844961 | G | helix | -0.6999999999999998 | 5.8 | ALA | -0.886 | -0.7298187808896212 | 8 | 8 | -0.993 | -0.827 | 9:8 | 150/150 | Q:G:S:E:A:C:V | 69 | 0.7263157894736842 | 80 | effect | pnca_p.ala79thr | 0.0001437401178668 | -9.98752126245055 | 4.59700131334282e-05 | 0.942832958100734 | 139.277183325396 | -0.0717096729269465 | 144471.70631481 | 1.2119588062211 | 0.0834878586628579 | 0.0 | 1.0 | 0.0 | 0.0 | 25.8386585962163 | 1.0105682238915901e-25 | 0.999999999999746 | -1.58 | -0.4136125654450262 | Destabilising | THR | 0 | pnca_complex.pdb | |
| 199 | A79V | A | 79 | V | A | PZA | 10.663 | -0.186 | Destabilising | -1.403 | Destabilising | -0.0480620155038759 | -0.3553698074974671 | A79 | AA79 | -0.825109 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -1.0 | 0.0 | -1.0 | 0.0 | -2.0 | 0.0 | -2.0 | -5.0 | -0.1586381988771822 | Stabilising | -1.839 | Destabilising | -0.3135549872122762 | 1 | 0.0077519379844961 | G | helix | -0.6999999999999998 | 5.8 | ALA | -0.886 | -0.7298187808896212 | 8 | 8 | -0.993 | -0.827 | 9:8 | 150/150 | Q:G:S:E:A:C:V | 25 | 0.2631578947368421 | 63 | effect | pnca_p.ala79val | 0.0003593502946672 | -10.9877909019996 | 1.69068633684892e-05 | 0.939691219428539 | 145.229797681911 | -0.0756579646696576 | 60.3389082676172 | 0.484657419083649 | -0.314565134742567 | 0.0 | 0.596111875058711 | 0.224672226566594 | 0.0 | 5.29224350433385 | 0.177777263899814 | 0.673290424524484 | -0.64 | -0.1675392670157068 | Destabilising | VAL | 0 | pnca_complex.pdb | |
| 200 | F81S | F | 81 | S | A | PZA | 11.313 | -2.584 | Destabilising | -0.596 | Destabilising | -0.6677002583979327 | -0.1509625126646403 | F81 | FA81 | 2.44385 | 32.0 | 4.0 | 0.0 | 0.0 | 4.0 | 0.0 | 0.0 | 0.0 | 0.0 | -2.0 | 0.0 | -2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 6.0 | 0.0 | 2.0 | 4.0 | 12.0 | 0.0 | 10.0 | 8.0 | 0.08901033661375737 | Destabilising | -1.725 | Destabilising | -0.29411764705882354 | 40 | 0.1666666666666666 | B | strand | -1.3 | 4.56 | PHE | -0.082 | -0.06754530477759474 | 5 | 5 | -0.332 | 0.083 | 6:5 | 150/150 | F:M:Y:P:V:L:I | 31 | 0.3263157894736842 | 66 | effect | pnca_p.phe81ser | 0.0001437401178668 | -9.98752126245058 | 4.59700131334266e-05 | 0.942832958100734 | 139.277183325397 | -0.0717096729269465 | 144471.70631483 | 1.2119588062211 | 0.0834878586628579 | 0.0 | 1.0 | 0.0 | 0.0 | 25.8386585962163 | 1.0105682238915901e-25 | 0.999999999999746 | -2.58 | -0.6753926701570682 | Destabilising | SER | 0 | pnca_complex.pdb | |
| 201 | F81C | F | 81 | C | A | PZA | 11.313 | -1.592 | Destabilising | -1.003 | Destabilising | -0.4113695090439276 | -0.2540526849037487 | F81 | FA81 | 2.56753 | 26.0 | 4.0 | 0.0 | 0.0 | 4.0 | 0.0 | 0.0 | 0.0 | 0.0 | -2.0 | 0.0 | -2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.0 | 0.0 | 2.0 | 0.0 | 10.0 | 0.0 | 10.0 | 6.0 | 0.09351503143233852 | Destabilising | -1.315 | Destabilising | -0.22421142369991473 | 40 | 0.1666666666666666 | B | strand | -1.3 | 4.56 | PHE | -0.082 | -0.06754530477759474 | 5 | 5 | -0.332 | 0.083 | 6:5 | 150/150 | F:M:Y:P:V:L:I | 55 | 0.5789473684210527 | 75 | effect | pnca_p.phe81cys | 7.18700589334483e-05 | 12.1451538387266 | 188179.926264665 | 0.919026337424239 | 119.468044436241 | 0.101660271548249 | 5.01153666061863e-06 | 9.70142977291842 | 0.986835744238421 | inf | 0.170978870202674 | 0.767057556984365 | 0.124324963210678 | inf | 0.763784339928386 | 0.382146811758261 | -1.85 | -0.4842931937172775 | Destabilising | CYS | 0 | pnca_complex.pdb | |
| 202 | F81V | F | 81 | V | A | PZA | 11.313 | -1.5630000000000002 | Destabilising | -1.967 | Destabilising | -0.4038759689922481 | -0.4982269503546099 | F81 | FA81 | 2.08972 | 32.0 | 4.0 | 0.0 | 0.0 | 4.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 4.0 | 0.0 | 2.0 | 2.0 | 10.0 | 0.0 | 8.0 | 6.0 | 0.07611215116660232 | Destabilising | -1.962 | Destabilising | -0.3345268542199488 | 40 | 0.1666666666666666 | B | strand | -1.3 | 4.56 | PHE | -0.082 | -0.06754530477759474 | 5 | 5 | -0.332 | 0.083 | 6:5 | 150/150 | F:M:Y:P:V:L:I | 56 | 0.5894736842105263 | 75 | effect | pnca_p.phe81val | 0.0003593502946672 | 0.192485717774876 | 1.21225918982515 | 0.863268405978748 | 1.11770505415734 | 0.172215126932565 | 0.0619550849552711 | 8.1990567174233 | 1.21225820016821 | 0.083595130527928 | 1.212214074125 | 1.0 | 0.0 | 0.0246053772172713 | 12.260612593354 | 7.1929763849897505e-25 | 0.999999999999323 | -1.92 | -0.5026178010471204 | Destabilising | VAL | 0 | pnca_complex.pdb |
| 203 | H82R | H | 82 | R | A | PZA | 11.736 | -0.6629999999999999 | Destabilising | -0.111 | Destabilising | -0.1713178294573643 | -0.0281155015197568 | H82 | HA82 | -0.0040868 | -34.0 | -18.0 | 0.0 | 0.0 | -18.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.0 | -2.0 | 0.0 | 0.0 | 0.0 | 0.0 | -5.0 | 0.0 | 2.0 | -5.0 | 2.0 | 0.0 | 2.0 | -2.0 | -0.0007857417519034069 | Stabilising | -0.923 | Destabilising | -0.15737425404944586 | 33 | 0.1473214285714285 | - | loop | -0.6666666666666669 | 4.73 | HIS | -0.684 | -0.5634266886326195 | 8 | 8 | -0.827 | -0.615 | 8:7 | 150/150 | D:P:S:A:I:R:V:H | 52 | 0.5473684210526316 | 75 | effect | pnca_p.his82arg | 0.0004312203536006 | 3.19016080361873 | 24.2923334241601 | 0.0035954281300594 | 1.09565968954934 | 2.91163472932996 | 3.915519774324 | 465.531063220231 | 24.2923336141533 | 1.38546923679232 | 24.2833096922897 | 0.0007494070007895 | 3.12528225414311 | 2.71567844828345 | 1141.60089496884 | 14.1977442691074 | 0.0001645676755807 | -0.05 | -0.013089005235602 | Destabilising | ARG | 0 | pnca_complex.pdb |
| 204 | H82D | H | 82 | D | A | PZA | 11.736 | -0.198 | Destabilising | 0.013 | Stabilising | -0.0511627906976744 | 0.005829596412556 | H82 | HA82 | 1.78228 | 26.0 | -20.0 | 0.0 | 0.0 | -20.0 | 0.0 | 0.0 | 0.0 | 0.0 | -2.0 | 0.0 | -2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -1.0 | 0.0 | 1.0 | 0.0 | 4.0 | 0.0 | 4.0 | -2.0 | 0.06491451715120303 | Destabilising | -1.413 | Destabilising | -0.24092071611253196 | 33 | 0.1473214285714285 | - | loop | -0.6666666666666669 | 4.73 | HIS | -0.684 | -0.5634266886326195 | 8 | 8 | -0.827 | -0.615 | 8:7 | 150/150 | D:P:S:A:I:R:V:H | 63 | 0.6631578947368421 | 80 | effect | pnca_p.his82asp | 0.0001437401178668 | 1.57903938912402 | 4.85029432717735 | 0.264247566376723 | 1.41439286276584 | 1.11640791656443 | 0.191756076673665 | 122.683760399245 | 4.85029436501262 | 0.685768096792206 | 4.84956447904112 | 0.312734154310187 | 0.504824686014995 | 0.061763864579114 | 379.558337204203 | 0.0881192621863332 | 0.766581879696361 | 0.3 | 0.1685393258426966 | Stabilising | ASP | 0 | pnca_complex.pdb |
| 205 | H82Y | H | 82 | Y | A | PZA | 11.736 | 0.591 | Stabilising | -0.973 | Destabilising | 0.5025510204081632 | -0.2464539007092198 | H82 | HA82 | -0.6673020000000001 | -26.0 | -4.0 | 0.0 | 0.0 | -4.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -4.0 | 0.0 | 0.0 | -6.0 | -2.0 | 0.0 | -2.0 | -4.0 | -0.1282977005306468 | Stabilising | -0.819 | Destabilising | -0.13964194373401534 | 33 | 0.1473214285714285 | - | loop | -0.6666666666666669 | 4.73 | HIS | -0.684 | -0.5634266886326195 | 8 | 8 | -0.827 | -0.615 | 8:7 | 150/150 | D:P:S:A:I:R:V:H | 62 | 0.6526315789473685 | 80 | effect | 1.23 | 0.6910112359550562 | Stabilising | TYR | 0 | pnca_complex.pdb | ||||||||||||||||||
| 206 | L85R | L | 85 | R | A | PZA | 12.428 | -1.371 | Destabilising | -0.8079999999999999 | Destabilising | -0.3542635658914728 | -0.204660587639311 | L85 | LA85 | 2.99904 | -50.0 | -32.0 | 0.0 | 0.0 | -32.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -3.0 | 0.0 | 1.0 | -5.0 | -8.0 | 0.0 | -6.0 | -6.0 | 0.10923156491524559 | Destabilising | -1.503 | Destabilising | -0.25626598465473144 | 9 | 0.044776119402985 | S | loop | -0.1666666666666666 | 5.61 | LEU | -0.734 | -0.6046128500823723 | 8 | 8 | -0.872 | -0.674 | 8:7 | 150/150 | F:V:L:I | 84 | 0.8842105263157894 | 91 | effect | pnca_p.leu85arg | 0.0009343107661348 | 3.28791485229524 | 26.7869506340703 | 1.90630753051074e-05 | 0.768996545261044 | 4.27559118770699 | 7.18677177006371 | 173.199151011595 | 26.7869510135135 | 1.42792328347145 | 26.7708032978517 | 1.9896368453757e-07 | 6.70122618511891 | 5.83859157504838 | 247.443798048456 | 37.2159659891988 | 1.0574446237829601e-09 | -0.82 | -0.2146596858638743 | Destabilising | ARG | 0 | pnca_complex.pdb |
| 207 | L85P | L | 85 | P | A | PZA | 12.428 | -1.891 | Destabilising | -1.426 | Destabilising | -0.4886304909560723 | -0.3611955420466058 | L85 | LA85 | 8.82868 | 18.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 1.0 | 0.0 | -1.0 | -2.0 | 4.0 | 0.0 | -2.0 | 8.0 | 0.3215597432964984 | Destabilising | -1.285 | Destabilising | -0.21909633418584823 | 9 | 0.044776119402985 | S | loop | -0.1666666666666666 | 5.61 | LEU | -0.734 | -0.6046128500823723 | 8 | 8 | -0.872 | -0.674 | 8:7 | 150/150 | F:V:L:I | 85 | 0.8947368421052632 | 91 | effect | pnca_p.leu85pro | 0.0005030904125341 | 3.37290329402598 | 29.1630732435189 | 0.001789077082818 | 1.07995768762031 | 3.12318096596747 | 4.97876379054104 | 550.894323518834 | 29.1630847029077 | 1.46483345924118 | 29.1293325978315 | 0.0001485295621003 | 3.828187099348 | 3.53443753556636 | 1331.56873199938 | 18.6717493808583 | 1.55265977742841e-05 | -1.32 | -0.3455497382198953 | Destabilising | PRO | 0 | pnca_complex.pdb |
| 208 | D86G | D | 86 | G | A | PZA | 17.129 | -0.094 | Destabilising | -1.107 | Destabilising | -0.0242894056847545 | -0.2803951367781155 | D86 | DA86 | 2.19531 | 4.0 | 14.0 | 0.0 | 0.0 | 14.0 | 0.0 | 0.0 | 0.0 | 0.0 | 4.0 | 0.0 | 2.0 | 2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 3.0 | 0.0 | 1.0 | 2.0 | 2.0 | 0.0 | 3.0 | 13.0 | 0.07995796880804784 | Destabilising | -0.796 | Destabilising | -0.13572037510656437 | 97 | 0.5025906735751295 | - | loop | -0.1333333333333334 | 3.88 | ASP | 1.31 | 0.4198717948717949 | 1 | 1 | 0.842 | 1.712 | 2:1 | 150/150 | D:P:A:G:S:T:K:R:N:L:V:Q:E:F:H | 15 | 0.15789473684210525 | 59 | effect | pnca_p.asp86gly | 7.18700589334483e-05 | -8.98740878149642 | 0.0001249735077034 | 0.940032862253633 | 119.468044435491 | -0.0752285585987753 | 4692673.51081135 | 2.42412778478352 | 0.384555509373631 | 0.0 | 1.0 | 0.0 | 0.0 | 188.544222231268 | 1.0341007080334399e-29 | 0.999999999999997 | 0.24 | 0.1348314606741573 | Stabilising | GLY | 0 | pnca_complex.pdb | |
| 209 | T87M | T | 87 | M | A | PZA | 17.594 | -0.4 | Destabilising | -0.6920000000000001 | Destabilising | -0.103359173126615 | -0.1752786220871327 | T87 | TA87 | -1.95982 | -22.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.0 | 0.0 | 2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -5.0 | 0.0 | -1.0 | -4.0 | -2.0 | 0.0 | -2.0 | 0.0 | -0.37680150734445894 | Stabilising | -0.061 | Destabilising | -0.010400682011935208 | 86 | 0.5 | - | loop | -1.6666666666666667 | 3.72 | THR | 1.003 | 0.32147435897435894 | 1 | 1 | 0.59 | 1.183 | 3:1 | 150/150 | I:R:L:V:N:Q:F:E:W:T:K:H:Y:D:P:G:M:A:S | -47 | -0.5053763440860215 | 72 | neutral | pnca_p.thr87met | 0.0007905706482679 | -11.9883149074727 | 6.21642915145485e-06 | 0.940801856882948 | 161.432542873449 | -0.0742620706710335 | 0.975080220739854 | 0.220184187397302 | -0.657213873251097 | 0.0 | 0.23001103975255 | 0.638251318814789 | 0.0 | 1.93160031351699 | 1.2237252074576 | 0.268630815579749 | -0.37 | -0.0968586387434555 | Destabilising | MET | 0 | pnca_complex.pdb | |
| 210 | I90T | I | 90 | T | A | PZA | 14.878 | -1.983 | Destabilising | 0.462 | Stabilising | -0.5124031007751938 | 0.2071748878923767 | I90 | IA90 | 2.28269 | 10.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -1.0 | 0.0 | -1.0 | 0.0 | 2.0 | 0.0 | 0.0 | 2.0 | 0.08314053861114956 | Destabilising | -2.457 | Destabilising | -0.418925831202046 | 24 | 0.1218274111675127 | - | loop | 0.9333333333333332 | 4.88 | ILE | 0.151 | 0.04839743589743589 | 4 | 4 | -0.147 | 0.225 | 6:4 | 147/150 | P:S:G:A:W:D:E:F:C:I:L:V:N | 42 | 0.4421052631578947 | 71 | effect | pnca_p.ile90thr | 0.0002874802357337 | 2.67848962960141 | 14.5630810302278 | 0.0202679102821363 | 1.15384949648317 | 2.3213509541454 | 1.8636331786073 | 294.488177945833 | 14.5631313131313 | 1.16325476548539 | 14.5631012253236 | 0.0174140488202037 | 1.75910024233227 | 1.16837785201846 | 760.989759542733 | 5.81873994206135 | 0.0158563003544608 | -1.55 | -0.4057591623036649 | Destabilising | THR | 0 | pnca_complex.pdb |
| 211 | I90S | I | 90 | S | A | PZA | 14.878 | -2.286 | Destabilising | 0.447 | Stabilising | -0.5906976744186047 | 0.2004484304932735 | I90 | IA90 | 4.11572 | 12.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -1.0 | 0.0 | -1.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.1499034812316523 | Destabilising | -2.665 | Destabilising | -0.45439045183290705 | 24 | 0.1218274111675127 | - | loop | 0.9333333333333332 | 4.88 | ILE | 0.151 | 0.04839743589743589 | 4 | 4 | -0.147 | 0.225 | 6:4 | 147/150 | P:S:G:A:W:D:E:F:C:I:L:V:N | 38 | 0.4 | 66 | effect | pnca_p.ile90ser | 0.0005030904125341 | 1.86781040138793 | 6.47410517670655 | 0.0145043045254535 | 0.764079088633845 | 2.44452495713176 | 1.42623754737829 | 32.8877353882374 | 6.47410526315789 | 0.811179756363585 | 6.47281975099898 | 0.0192724555107824 | 1.71506294819644 | 1.09429403734416 | 44.2397805449942 | 5.34879705543722 | 0.0207365726835135 | -1.93 | -0.5052356020942408 | Destabilising | SER | 0 | pnca_complex.pdb |
| 212 | A92V | A | 92 | V | A | PZA | 15.57 | 0.941 | Stabilising | -1.7819999999999998 | Destabilising | 0.8001700680272109 | -0.4513677811550151 | A92 | AA92 | -1.35941 | 0.0 | 2.0 | 0.0 | 0.0 | 2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -6.0 | 0.0 | 0.0 | -6.0 | -4.0 | 0.0 | -2.0 | -3.0 | -0.2613646850726755 | Stabilising | -0.312 | Destabilising | -0.053196930946291555 | 11 | 0.0852713178294573 | E | strand | 0.8333333333333334 | 4.62 | ALA | 0.318 | 0.10192307692307692 | 4 | 4 | 0.083 | 0.389 | 5:4 | 150/150 | I:R:V:L:Q:E:F:W:T:K:Y:H:P:M:S:A:G | -40 | -0.43010752688172044 | 66 | neutral | 0.55 | 0.3089887640449438 | Stabilising | VAL | 0 | pnca_complex.pdb | ||||||||||||||||||
| 213 | A92G | A | 92 | G | A | PZA | 15.57 | -0.574 | Destabilising | -1.692 | Destabilising | -0.1483204134366925 | -0.4285714285714285 | A92 | AA92 | 1.40665 | 6.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.0 | 0.0 | 0.0 | 0.0 | 3.0 | 12.0 | 0.051233254904246094 | Destabilising | -1.618 | Destabilising | -0.2758738277919864 | 11 | 0.0852713178294573 | E | strand | 0.8333333333333334 | 4.62 | ALA | 0.318 | 0.10192307692307692 | 4 | 4 | 0.083 | 0.389 | 5:4 | 150/150 | I:R:V:L:Q:E:F:W:T:K:Y:H:P:M:S:A:G | 12 | 0.12631578947368421 | 59 | effect | -0.96 | -0.2513089005235602 | Destabilising | GLY | 0 | pnca_complex.pdb | ||||||||||||||||||
| 214 | A92P | A | 92 | P | A | PZA | 15.57 | 0.14 | Stabilising | -1.787 | Destabilising | 0.119047619047619 | -0.4526342451874366 | A92 | AA92 | 0.275359 | 0.0 | 2.0 | 0.0 | 0.0 | 2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -6.0 | 2.0 | -2.0 | -6.0 | 2.0 | 0.0 | 0.0 | -3.0 | 0.010029174163564712 | Destabilising | -2.918 | Destabilising | -0.49752770673486785 | 11 | 0.0852713178294573 | E | strand | 0.8333333333333334 | 4.62 | ALA | 0.318 | 0.10192307692307692 | 4 | 4 | 0.083 | 0.389 | 5:4 | 150/150 | I:R:V:L:Q:E:F:W:T:K:Y:H:P:M:S:A:G | 9 | 0.09473684210526316 | 53 | effect | pnca_p.ala92pro | 7.18700589334483e-05 | -8.98740878149641 | 0.0001249735077034 | 0.940032862253633 | 119.46804443549 | -0.0752285585987756 | 4692673.5108108 | 2.42412778478352 | 0.384555509373631 | 0.0 | 1.0 | 0.0 | 0.0 | 188.544222231268 | 1.0341007080334399e-29 | 0.999999999999997 | 0.76 | 0.4269662921348314 | Stabilising | PRO | 0 | pnca_complex.pdb | |
| 215 | V93G | V | 93 | G | A | PZA | 13.206 | -2.333 | Destabilising | -0.958 | Destabilising | -0.602842377260982 | -0.2426545086119554 | V93 | VA93 | 3.06107 | 4.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.0 | 0.0 | 0.0 | 1.0 | 4.0 | 0.0 | 13.0 | 15.0 | 0.1114908325381158 | Destabilising | -2.536 | Destabilising | -0.43239556692242115 | 27 | 0.1551724137931034 | E | strand | 2.9333333333333336 | 4.76 | VAL | -0.095 | -0.07825370675453049 | 5 | 5 | -0.332 | -0.038 | 6:5 | 150/150 | W:T:A:S:K:I:C:R:L:V:Q:H:Y:E | 41 | 0.43157894736842106 | 71 | effect | -2.72 | -0.712041884816754 | Destabilising | GLY | 0 | pnca_complex.pdb | ||||||||||||||||||
| 216 | V93L | V | 93 | L | A | PZA | 13.206 | -0.015 | Destabilising | -1.213 | Destabilising | -0.003875968992248 | -0.3072441742654508 | V93 | VA93 | -1.8226 | -14.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -2.0 | 0.0 | 0.0 | -2.0 | 0.0 | 0.0 | 0.0 | 0.0 | -8.0 | 0.0 | -5.0 | -4.0 | 0.0 | 0.0 | 2.0 | -2.0 | -0.3504191340459894 | Stabilising | -0.026 | Destabilising | -0.00443307757885763 | 27 | 0.1551724137931034 | E | strand | 2.9333333333333336 | 4.76 | VAL | -0.095 | -0.07825370675453049 | 5 | 5 | -0.332 | -0.038 | 6:5 | 150/150 | W:T:A:S:K:I:C:R:L:V:Q:H:Y:E | -1 | -0.010752688172043012 | 53 | neutral | -0.52 | -0.1361256544502617 | Destabilising | LEU | 0 | pnca_complex.pdb | ||||||||||||||||||
| 217 | F94V | F | 94 | V | A | PZA | 10.621 | -1.995 | Destabilising | -1.681 | Destabilising | -0.5155038759689923 | -0.4257852077001013 | F94 | FA94 | 2.56655 | 30.0 | 4.0 | 0.0 | 0.0 | 4.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -1.0 | 0.0 | -3.0 | 2.0 | 4.0 | 0.0 | 6.0 | 2.0 | 0.09347933769913824 | Destabilising | -2.927 | Destabilising | -0.4990622335890878 | 0 | 0.0 | E | strand | 1.9 | 7.59 | PHE | -0.13 | -0.1070840197693575 | 5 | 5 | -0.332 | -0.038 | 6:5 | 150/150 | A:F:Q:V:L:I | -5 | -0.053763440860215055 | 53 | neutral | pnca_p.phe94val | 7.18700589334483e-05 | -8.9874087814964 | 0.0001249735077034 | 0.940032862253633 | 119.46804443549 | -0.0752285585987757 | 4692673.51081231 | 2.42412778478352 | 0.384555509373631 | 0.0 | 1.0 | 0.0 | 0.0 | 188.544222231268 | 1.0341007080334399e-29 | 0.999999999999997 | -1.82 | -0.4764397905759163 | Destabilising | VAL | 0 | pnca_complex.pdb | |
| 218 | F94S | F | 94 | S | A | PZA | 10.621 | -3.027 | Destabilising | -0.449 | Destabilising | -0.7821705426356588 | -0.1137284701114488 | F94 | FA94 | 5.85272 | 32.0 | 4.0 | 0.0 | 0.0 | 4.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -1.0 | 0.0 | -3.0 | 0.0 | 6.0 | 0.0 | 10.0 | 6.0 | 0.21316880222029588 | Destabilising | -3.24 | Destabilising | -0.5524296675191817 | 0 | 0.0 | E | strand | 1.9 | 7.59 | PHE | -0.13 | -0.1070840197693575 | 5 | 5 | -0.332 | -0.038 | 6:5 | 150/150 | A:F:Q:V:L:I | 69 | 0.7263157894736842 | 80 | effect | pnca_p.phe94ser | 0.0001437401178668 | 13.1456002256206 | 511754.463552622 | 0.924803768446999 | 139.277183326568 | 0.0943844491369244 | 0.0001628371344452 | 19.411022297013 | 1.28804840845689 | inf | 0.0292235860951597 | 1.53426649183163 | 0.91081598550184 | inf | 4.73122070382274 | 0.0296198560706035 | -2.74 | -0.7172774869109948 | Destabilising | SER | 0 | pnca_complex.pdb | |
| 219 | F94C | F | 94 | C | A | PZA | 10.621 | -1.595 | Destabilising | -1.615 | Destabilising | -0.4121447028423772 | -0.4090678824721377 | F94 | FA94 | 4.52813 | 28.0 | 4.0 | 0.0 | 0.0 | 4.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.0 | 0.0 | 0.0 | 2.0 | 8.0 | 0.0 | 8.0 | 6.0 | 0.16492435113892145 | Destabilising | -3.58 | Destabilising | -0.6104006820119352 | 0 | 0.0 | E | strand | 1.9 | 7.59 | PHE | -0.13 | -0.1070840197693575 | 5 | 5 | -0.332 | -0.038 | 6:5 | 150/150 | A:F:Q:V:L:I | 49 | 0.5157894736842106 | 71 | effect | pnca_p.phe94cys | 0.0002874802357337 | 2.67848962960141 | 14.5630810302278 | 0.0202679102821361 | 1.15384949648317 | 2.3213509541454 | 1.86363317860726 | 294.488177945833 | 14.5631313131313 | 1.16325476548539 | 14.5631012253236 | 0.0174140488202037 | 1.75910024233227 | 1.16837785201846 | 760.989759542733 | 5.81873994206135 | 0.0158563003544608 | -1.42 | -0.3717277486910995 | Destabilising | CYS | 0 | pnca_complex.pdb |
| 220 | F94L | F | 94 | L | A | PZA | 10.621 | -1.582 | Destabilising | -1.712 | Destabilising | -0.4087855297157622 | -0.4336372847011145 | F94 | FA94 | 1.1796 | 16.0 | 4.0 | 0.0 | 0.0 | 4.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -3.0 | 0.0 | -1.0 | -3.0 | 2.0 | 0.0 | 6.0 | 2.0 | 0.04296359967657107 | Destabilising | -2.563 | Destabilising | -0.436999147485081 | 0 | 0.0 | E | strand | 1.9 | 7.59 | PHE | -0.13 | -0.1070840197693575 | 5 | 5 | -0.332 | -0.038 | 6:5 | 150/150 | A:F:Q:V:L:I | 24 | 0.25263157894736843 | 63 | effect | pnca_p.phe94leu | 0.0005030904125341 | 1.86781040138793 | 6.47410517670654 | 0.0145043045254536 | 0.764079088633845 | 2.44452495713176 | 1.42623754737775 | 32.8877353882363 | 6.47410526315789 | 0.811179756363585 | 6.47281975099898 | 0.0192724555107824 | 1.71506294819644 | 1.09429403734416 | 44.2397805449942 | 5.34879705543722 | 0.0207365726835135 | -1.99 | -0.5209424083769634 | Destabilising | LEU | 0 | pnca_complex.pdb |
| 221 | Y95D | Y | 95 | D | A | PZA | 10.528 | -0.772 | Destabilising | 0.071 | Stabilising | -0.1994832041343669 | 0.0318385650224215 | Y95 | YA95 | 4.78106 | 38.0 | -12.0 | 0.0 | 0.0 | -12.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.0 | 0.0 | 0.0 | 2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 1.0 | 0.0 | 1.0 | 1.0 | 4.0 | 0.0 | 2.0 | 2.0 | 0.17413661230049754 | Destabilising | -2.558 | Destabilising | -0.43614663256606984 | 75 | 0.2851711026615969 | E | strand | -0.8000000000000002 | 4.15 | TYR | -0.013 | -0.010708401976935749 | 5 | 5 | -0.244 | 0.083 | 6:5 | 150/150 | K:Y:H:D:G:S:M:P:L:N:C:R:E:F:Q:T | 46 | 0.4842105263157895 | 71 | effect | pnca_p.tyr95asp | 7.18700589334483e-05 | 12.1451538387253 | 188179.926264427 | 0.919026337424197 | 119.468044436166 | 0.101660271548303 | 5.01153666068889e-06 | 9.70142977291842 | 0.986835744238421 | inf | 0.170978870202674 | 0.767057556984365 | 0.124324963210678 | inf | 0.763784339928386 | 0.382146811758261 | -0.4 | -0.1047120418848167 | Destabilising | ASP | 0 | pnca_complex.pdb | |
| 222 | K96M | K | 96 | M | A | PZA | 3.977 | 0.413 | Stabilising | -1.026 | Destabilising | 0.3511904761904761 | -0.2598784194528875 | K96 | KA96 | 0.273257 | 24.0 | 32.0 | 0.0 | 0.0 | 32.0 | 0.0 | 0.0 | 0.0 | 0.0 | 4.0 | 0.0 | 0.0 | 4.0 | 0.0 | 0.0 | 0.0 | 0.0 | -5.0 | 0.0 | -5.0 | 0.0 | -2.0 | 0.0 | -2.0 | -4.0 | 0.009952614748067804 | Destabilising | -0.457 | Destabilising | -0.07791986359761296 | 8 | 0.0338983050847457 | E | strand | -1.8666666666666665 | 5.96 | LYS | -1.194 | -0.9835255354200988 | 9 | 9 | -1.229 | -1.178 | 9:9 | 150/150 | K:Q | 84 | 0.8842105263157894 | 91 | effect | pnca_p.lys96met | 0.0001437401178668 | 13.1456002256221 | 511754.463553382 | 0.924803768447045 | 139.277183326669 | 0.0943844491368667 | 0.0001628371344428 | 19.411022297013 | 1.28804840845689 | inf | 0.0292235860951597 | 1.53426649183163 | 0.91081598550184 | inf | 4.73122070382274 | 0.0296198560706035 | 1.02 | 0.5730337078651685 | Stabilising | MET | 0 | pnca_complex.pdb | |
| 223 | K96N | K | 96 | N | A | PZA | 3.977 | -1.156 | Destabilising | 0.325 | Stabilising | -0.2987080103359172 | 0.1457399103139013 | K96 | KA96 | 2.61245 | 52.0 | 6.0 | 0.0 | 0.0 | 6.0 | 0.0 | 0.0 | 0.0 | 0.0 | 4.0 | 0.0 | 2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -3.0 | 0.0 | -1.0 | -3.0 | 6.0 | 0.0 | 4.0 | -2.0 | 0.09515111561127339 | Destabilising | -3.151 | Destabilising | -0.5372549019607843 | 8 | 0.0338983050847457 | E | strand | -1.8666666666666665 | 5.96 | LYS | -1.194 | -0.9835255354200988 | 9 | 9 | -1.229 | -1.178 | 9:9 | 150/150 | K:Q | 90 | 0.9473684210526315 | 95 | effect | pnca_p.lys96asn | 7.18700589334483e-05 | -8.98740878149641 | 0.0001249735077034 | 0.940032862253633 | 119.468044435491 | -0.0752285585987751 | 4692673.51081327 | 2.42412778478352 | 0.384555509373631 | 0.0 | 1.0 | 0.0 | 0.0 | 188.544222231268 | 1.0341007080334399e-29 | 0.999999999999997 | -0.85 | -0.2225130890052356 | Destabilising | ASN | 0 | pnca_complex.pdb | |
| 224 | K96T | K | 96 | T | A | PZA | 3.977 | -0.86 | Destabilising | -0.57 | Destabilising | -0.2222222222222222 | -0.1443768996960486 | K96 | KA96 | 3.53764 | 72.0 | 8.0 | 0.0 | 0.0 | 8.0 | 0.0 | 0.0 | 0.0 | 0.0 | 4.0 | 0.0 | 0.0 | 4.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 8.0 | 0.0 | 6.0 | 4.0 | 0.12884854930470066 | Destabilising | -0.932 | Destabilising | -0.1589087809036658 | 8 | 0.0338983050847457 | E | strand | -1.8666666666666665 | 5.96 | LYS | -1.194 | -0.9835255354200988 | 9 | 9 | -1.229 | -1.178 | 9:9 | 150/150 | K:Q | 85 | 0.8947368421052632 | 91 | effect | pnca_p.lys96thr | 0.0009343107661348 | 4.06858121107736 | 58.473941530631 | 9.193364498612e-05 | 1.04030498364652 | 3.91095041842056 | 11.5166635599539 | 1065.61332397744 | 58.4740177439797 | 1.76696293519342 | 58.4547574725378 | 6.68324361543955e-09 | 8.17501270782547 | 8.64086529870195 | 2465.74647273772 | 46.7514830195167 | 8.05839318437163e-12 | -0.61 | -0.1596858638743455 | Destabilising | THR | 0 | pnca_complex.pdb |
| 225 | K96R | K | 96 | R | A | PZA | 3.977 | -0.1689999999999999 | Destabilising | 0.083 | Stabilising | -0.0436692506459948 | 0.037219730941704 | K96 | KA96 | -0.740521 | -12.0 | -4.0 | 0.0 | 0.0 | -4.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -2.0 | 2.0 | 0.0 | 0.0 | 0.0 | 0.0 | -5.0 | 0.0 | -3.0 | -5.0 | -8.0 | 0.0 | -6.0 | -8.0 | -0.14237502883949857 | Stabilising | -2.045 | Destabilising | -0.3486786018755328 | 8 | 0.0338983050847457 | E | strand | -1.8666666666666665 | 5.96 | LYS | -1.194 | -0.9835255354200988 | 9 | 9 | -1.229 | -1.178 | 9:9 | 150/150 | K:Q | 85 | 0.8947368421052632 | 91 | effect | pnca_p.lys96arg | 0.0010780508840017 | 2.9697959800773 | 19.4879432617414 | 4.2195571364394e-06 | 0.645570763650269 | 4.60026405670093 | 6.18542852926305 | 85.5881348249979 | 19.4879594423321 | 1.28976636711505 | 19.4791388432651 | 1.66262776179573e-07 | 6.77920497212353 | 5.25121653678864 | 107.844057222035 | 37.591449001387 | 8.72260296739213e-10 | -0.35 | -0.0916230366492146 | Destabilising | ARG | 0 | pnca_complex.pdb |
| 226 | K96Q | K | 96 | Q | A | PZA | 3.977 | -1.318 | Destabilising | -0.08 | Destabilising | -0.3405684754521964 | -0.0202634245187436 | K96 | KA96 | 1.04409 | 26.0 | 8.0 | 0.0 | 0.0 | 8.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -2.0 | 0.0 | -2.0 | -1.0 | 2.0 | 0.0 | 2.0 | -2.0 | 0.03802803050721523 | Destabilising | -1.359 | Destabilising | -0.23171355498721227 | 8 | 0.0338983050847457 | E | strand | -1.8666666666666665 | 5.96 | LYS | -1.194 | -0.9835255354200988 | 9 | 9 | -1.229 | -1.178 | 9:9 | 150/150 | K:Q | 78 | 0.8210526315789474 | 85 | effect | pnca_p.lys96gln | 0.0002874802357337 | 1.57937329521209 | 4.85191414039981 | 0.114342297004304 | 1.0002536454007 | 1.57897279602454 | 0.58188909131153 | 40.4562911075298 | 4.85191417753471 | 0.685913110299906 | 4.85118443551178 | 0.137954936368295 | 0.860262754777729 | 0.351471331417763 | 67.0421060419706 | 1.17497090855698 | 0.278382201819561 | -0.86 | -0.225130890052356 | Destabilising | GLN | 0 | pnca_complex.pdb |
| 227 | K96E | K | 96 | E | A | PZA | 3.977 | -2.119 | Destabilising | -0.6729999999999999 | Destabilising | -0.547545219638243 | -0.1704660587639311 | K96 | KA96 | 6.924869999999999 | 26.0 | -2.0 | 0.0 | 0.0 | -2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 4.0 | 0.0 | -4.0 | 4.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -2.0 | 1.0 | -2.0 | 0.0 | 0.0 | -2.0 | 0.2522188390066944 | Destabilising | -2.7 | Destabilising | -0.4603580562659847 | 8 | 0.0338983050847457 | E | strand | -1.8666666666666665 | 5.96 | LYS | -1.194 | -0.9835255354200988 | 9 | 9 | -1.229 | -1.178 | 9:9 | 150/150 | K:Q | 89 | 0.9368421052631579 | 91 | effect | pnca_p.lys96glu | 0.0007905706482679 | 15.1494066679806 | 3795803.48339079 | 0.925233417916433 | 161.43254287942 | 0.0938435732830911 | 24.1993753459371 | 107.166385135135 | 2.03005858162844 | inf | 3.5812015819156903e-09 | 8.44597123233921 | 12.2081619622864 | inf | 47.6847963834956 | 5.0055851012886495e-12 | -1.84 | -0.4816753926701571 | Destabilising | GLU | 0 | pnca_complex.pdb | |
| 228 | G97D | G | 97 | D | A | PZA | 8.236 | -2.974 | Destabilising | -0.248 | Destabilising | -0.7684754521963824 | -0.0628166160081053 | G97 | GA97 | 12.1049 | -16.0 | -66.0 | 0.0 | 0.0 | -66.0 | 0.0 | 0.0 | 0.0 | 0.0 | -6.0 | 0.0 | 0.0 | -6.0 | 0.0 | 0.0 | 0.0 | 0.0 | -13.0 | 0.0 | -9.0 | -13.0 | -8.0 | 0.0 | -15.0 | -23.0 | 0.4408868071591431 | Destabilising | -2.263 | Destabilising | -0.385848252344416 | 7 | 0.0673076923076923 | - | loop | -0.8333333333333331 | 4.92 | GLY | -1.026 | -0.8451400329489293 | 9 | 9 | -1.124 | -0.993 | 9:9 | 150/150 | A:G | 83 | 0.8736842105263158 | 91 | effect | pnca_p.gly97asp | 0.0025154520626706 | 3.38272170811945 | 29.4508186631222 | 2.5998520960761497e-12 | 0.483396852654822 | 6.9978149206837 | 12.4656214812387 | 86.4946048523286 | 29.4508301404853 | 1.46909754090074 | 29.4177544871982 | 1.1100950551901799e-18 | 17.9546398318646 | 11.2940206861184 | 97.32420575844 | 111.74678026952 | 4.05989172191837e-26 | -1.49 | -0.3900523560209424 | Destabilising | ASP | 0 | pnca_complex.pdb |
| 229 | G97C | G | 97 | C | A | PZA | 8.236 | -1.635 | Destabilising | -1.158 | Destabilising | -0.4224806201550387 | -0.2933130699088145 | G97 | GA97 | 4.47159 | -10.0 | -2.0 | 0.0 | 0.0 | -2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.0 | -2.0 | 0.0 | 0.0 | 0.0 | 0.0 | -9.0 | 0.0 | -3.0 | -11.0 | -8.0 | 0.0 | -7.0 | -21.0 | 0.16286504126632623 | Destabilising | -1.484 | Destabilising | -0.2530264279624893 | 7 | 0.0673076923076923 | - | loop | -0.8333333333333331 | 4.92 | GLY | -1.026 | -0.8451400329489293 | 9 | 9 | -1.124 | -0.993 | 9:9 | 150/150 | A:G | 69 | 0.7263157894736842 | 80 | effect | pnca_p.gly97cys | 0.0007187005893344 | 14.1489809714057 | 1395803.74890115 | 0.890414731995348 | 102.692976013979 | 0.137779442378606 | 507.712885369765 | 97.3828619670747 | 1.98848253379833 | inf | 2.1018584548314e-08 | 7.67739653395739 | 10.9022485555592 | inf | 42.8452490786805 | 5.924579267292849e-11 | -0.7 | -0.1832460732984293 | Destabilising | CYS | 0 | pnca_complex.pdb | |
| 230 | G97S | G | 97 | S | A | PZA | 8.236 | -1.999 | Destabilising | -0.309 | Destabilising | -0.5165374677002584 | -0.0782674772036474 | G97 | GA97 | 5.99386 | -6.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -4.0 | 0.0 | -2.0 | -2.0 | 0.0 | 0.0 | 0.0 | 0.0 | -7.0 | 0.0 | -3.0 | -4.0 | -4.0 | 0.0 | -7.0 | -19.0 | 0.21830942824466962 | Destabilising | -2.075 | Destabilising | -0.3537936913895993 | 7 | 0.0673076923076923 | - | loop | -0.8333333333333331 | 4.92 | GLY | -1.026 | -0.8451400329489293 | 9 | 9 | -1.124 | -0.993 | 9:9 | 150/150 | A:G | 72 | 0.7578947368421053 | 85 | effect | pnca_p.gly97ser | 0.000646830530401 | 14.1485589414412 | 1395214.80217992 | 0.896008552350388 | 108.247901040098 | 0.130705157379451 | 226.474535582214 | 87.6075949367089 | 1.94254175795031 | inf | 1.23317897951184e-07 | 6.90897388676731 | 9.59561062779463 | inf | 38.0099632572142 | 7.038428913028e-10 | -1.28 | -0.3350785340314136 | Destabilising | SER | 0 | pnca_complex.pdb | |
| 231 | G97R | G | 97 | R | A | PZA | 8.236 | -1.252 | Destabilising | -0.89 | Destabilising | -0.3235142118863049 | -0.2254305977710233 | G97 | GA97 | 4.89479 | -78.0 | -34.0 | 0.0 | 0.0 | -34.0 | 0.0 | 0.0 | 0.0 | 0.0 | -4.0 | 0.0 | 0.0 | -6.0 | 0.0 | 0.0 | 0.0 | 0.0 | -16.0 | 0.0 | -10.0 | -15.0 | -16.0 | 0.0 | -13.0 | -27.0 | 0.1782789064605657 | Destabilising | -2.091 | Destabilising | -0.3565217391304348 | 7 | 0.0673076923076923 | - | loop | -0.8333333333333331 | 4.92 | GLY | -1.026 | -0.8451400329489293 | 9 | 9 | -1.124 | -0.993 | 9:9 | 150/150 | A:G | 82 | 0.8631578947368421 | 91 | effect | pnca_p.gly97arg | 0.0001437401178668 | 13.1456002256219 | 511754.463553323 | 0.924803768447043 | 139.277183326664 | 0.0943844491368691 | 0.0001628371344429 | 19.411022297013 | 1.28804840845689 | inf | 0.0292235860951597 | 1.53426649183163 | 0.91081598550184 | inf | 4.73122070382274 | 0.0296198560706035 | -0.79 | -0.2068062827225131 | Destabilising | ARG | 0 | pnca_complex.pdb | |
| 232 | G97A | G | 97 | A | A | PZA | 8.236 | -1.126 | Destabilising | -1.721 | Destabilising | -0.2909560723514211 | -0.4359169199594731 | G97 | GA97 | 3.72826 | -6.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.0 | -2.0 | 0.0 | 0.0 | 0.0 | 0.0 | -4.0 | 0.0 | 0.0 | -4.0 | -2.0 | 0.0 | -1.0 | -16.0 | 0.1357913446339207 | Destabilising | -1.921 | Destabilising | -0.32753623188405795 | 7 | 0.0673076923076923 | - | loop | -0.8333333333333331 | 4.92 | GLY | -1.026 | -0.8451400329489293 | 9 | 9 | -1.124 | -0.993 | 9:9 | 150/150 | A:G | 66 | 0.6947368421052632 | 80 | effect | -0.73 | -0.1910994764397905 | Destabilising | ALA | 0 | pnca_complex.pdb | ||||||||||||||||||
| 233 | G97V | G | 97 | V | A | PZA | 8.236 | -0.588 | Destabilising | -1.664 | Destabilising | -0.151937984496124 | -0.4214792299898683 | G97 | GA97 | 6.12241 | -8.0 | -2.0 | 0.0 | 0.0 | -2.0 | 0.0 | 0.0 | 0.0 | 0.0 | -2.0 | 0.0 | 0.0 | -2.0 | 0.0 | 0.0 | 0.0 | 0.0 | -14.0 | 0.0 | -8.0 | -9.0 | -12.0 | 0.0 | -11.0 | -23.0 | 0.22299149906395008 | Destabilising | -2.616 | Destabilising | -0.44603580562659845 | 7 | 0.0673076923076923 | - | loop | -0.8333333333333331 | 4.92 | GLY | -1.026 | -0.8451400329489293 | 9 | 9 | -1.124 | -0.993 | 9:9 | 150/150 | A:G | 77 | 0.8105263157894737 | 85 | effect | pnca_p.gly97val | 7.18700589334483e-05 | 12.1451538387264 | 188179.926264625 | 0.919026337424232 | 119.468044436229 | 0.101660271548258 | 5.01153666063045e-06 | 9.70142977291842 | 0.986835744238421 | inf | 0.170978870202674 | 0.767057556984365 | 0.124324963210678 | inf | 0.763784339928386 | 0.382146811758261 | -1.24 | -0.3246073298429319 | Destabilising | VAL | 0 | pnca_complex.pdb | |
| 234 | T100A | T | 100 | A | A | PZA | 8.272 | -0.5429999999999999 | Destabilising | -1.759 | Destabilising | -0.1403100775193798 | -0.4455420466058764 | T100 | TA100 | 0.408316 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.0 | 0.0 | 2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.0 | 0.0 | 2.0 | 5.0 | 0.01487175751571617 | Destabilising | 0.129 | Stabilising | 0.10895270270270271 | 81 | 0.4709302325581395 | S | loop | -0.8000000000000002 | 4.18 | THR | 1.347 | 0.4317307692307692 | 1 | 1 | 0.842 | 1.712 | 2:1 | 150/150 | K:Y:D:P:A:G:S:R:I:V:L:N:Q:F:E:T | -36 | -0.3870967741935484 | 66 | neutral | pnca_p.thr100ala | 0.0002874802357337 | 1.57937329521209 | 4.85191414039982 | 0.114342297004304 | 1.0002536454007 | 1.57897279602454 | 0.581889091312076 | 40.456291107557 | 4.85191417753471 | 0.685913110299906 | 4.85118443551178 | 0.137954936368295 | 0.860262754777729 | 0.351471331417763 | 67.0421060419706 | 1.17497090855698 | 0.278382201819561 | -0.1 | -0.0261780104712041 | Destabilising | ALA | 0 | pnca_complex.pdb |
| 235 | T100I | T | 100 | I | A | PZA | 8.272 | 0.379 | Stabilising | -1.537 | Destabilising | 0.3222789115646258 | -0.3893110435663627 | T100 | TA100 | 0.8080149999999999 | -6.0 | 2.0 | 0.0 | 0.0 | 2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.0 | 0.0 | 2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -1.0 | 0.0 | -3.0 | 0.0 | 0.0 | 0.0 | 0.0 | -2.0 | 0.029429665134507097 | Destabilising | -0.042 | Destabilising | -0.007161125319693095 | 81 | 0.4709302325581395 | S | loop | -0.8000000000000002 | 4.18 | THR | 1.347 | 0.4317307692307692 | 1 | 1 | 0.842 | 1.712 | 2:1 | 150/150 | K:Y:D:P:A:G:S:R:I:V:L:N:Q:F:E:T | 14 | 0.14736842105263157 | 59 | effect | pnca_p.thr100ile | 0.000646830530401 | 3.66142892829214 | 38.9169126367816 | 0.0005578275078108 | 1.06087424525349 | 3.45133171502081 | 7.13685172054609 | 722.165073757354 | 38.9169126950654 | 1.59013838008863 | 38.9145296299157 | 5.5228318480997e-06 | 5.25783817940065 | 5.21074959149254 | 1710.75565736304 | 27.8738145664613 | 1.29490403629991e-07 | -0.36 | -0.094240837696335 | Destabilising | ILE | 0 | pnca_complex.pdb |
| 236 | T100P | T | 100 | P | A | PZA | 8.272 | -0.488 | Destabilising | -1.685 | Destabilising | -0.1260981912144702 | -0.4267983789260385 | T100 | TA100 | 1.6514099999999998 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.0 | 0.0 | 2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.0 | 0.0 | -2.0 | 0.0 | 0.0 | -2.0 | -4.0 | 0.060147946881897445 | Destabilising | -0.412 | Destabilising | -0.07024722932651321 | 81 | 0.4709302325581395 | S | loop | -0.8000000000000002 | 4.18 | THR | 1.347 | 0.4317307692307692 | 1 | 1 | 0.842 | 1.712 | 2:1 | 150/150 | K:Y:D:P:A:G:S:R:I:V:L:N:Q:F:E:T | 18 | 0.18947368421052632 | 59 | effect | pnca_p.thr100pro | 0.0005030904125341 | 14.1477154154513 | 1394038.39846607 | 0.908235680148 | 122.741582019402 | 0.115264242017142 | 22.9578143501725 | 68.0817875210792 | 1.83303094984313 | inf | 4.24048522418865e-06 | 5.37258444573496 | 7.00237574052121 | inf | 28.35828361563 | 1.00814491180914e-07 | 0.03 | 0.0168539325842696 | Stabilising | PRO | 0 | pnca_complex.pdb | |
| 237 | A102T | A | 102 | T | A | PZA | 3.5 | -0.7190000000000001 | Destabilising | 0.8809999999999999 | Stabilising | -0.1857881136950904 | 0.395067264573991 | A102 | AA102 | -2.02927 | -2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -2.0 | 0.0 | 0.0 | -2.0 | 0.0 | 0.0 | 0.0 | 0.0 | -5.0 | 0.0 | -3.0 | -3.0 | -4.0 | 0.0 | -2.0 | -5.0 | -0.39015419518572636 | Stabilising | -1.769 | Destabilising | -0.301619778346121 | 10 | 0.0775193798449612 | - | loop | 0.0333333333333332 | 5.51 | ALA | -0.862 | -0.7100494233937397 | 8 | 8 | -0.955 | -0.827 | 9:8 | 150/150 | M:E:S:G:A:H:Q | 71 | 0.7473684210526316 | 85 | effect | pnca_p.ala102thr | 0.0001437401178668 | 13.1456002256202 | 511754.463552419 | 0.924803768446987 | 139.277183326542 | 0.0943844491369395 | 0.0001628371344458 | 19.411022297013 | 1.28804840845689 | inf | 0.0292235860951597 | 1.53426649183163 | 0.91081598550184 | inf | 4.73122070382274 | 0.0296198560706035 | -0.2 | -0.0523560209424083 | Destabilising | THR | 0 | pnca_complex.pdb | |
| 238 | A102P | A | 102 | P | A | PZA | 3.5 | -1.249 | Destabilising | -0.23 | Destabilising | -0.3227390180878553 | -0.058257345491388 | A102 | AA102 | -0.6167819999999999 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.0 | -2.0 | 0.0 | 0.0 | 0.0 | 0.0 | -8.0 | 0.0 | -2.0 | -6.0 | -6.0 | 0.0 | -2.0 | -5.0 | -0.11858455740982848 | Stabilising | -2.115 | Destabilising | -0.360613810741688 | 10 | 0.0775193798449612 | - | loop | 0.0333333333333332 | 5.51 | ALA | -0.862 | -0.7100494233937397 | 8 | 8 | -0.955 | -0.827 | 9:8 | 150/150 | M:E:S:G:A:H:Q | 83 | 0.8736842105263158 | 91 | effect | pnca_p.ala102pro | 0.0005749604714675 | 2.6796663501904 | 14.5802277940116 | 0.0010245352377103 | 0.816050632122414 | 3.28370108999368 | 3.35697961122126 | 99.5538692592317 | 14.5802781289507 | 1.16376580853041 | 14.5801759034061 | 0.0005075351447614 | 3.29453387923245 | 2.60435121163486 | 147.676327006136 | 15.0663448164144 | 0.0001037975122989 | 0.13 | 0.0730337078651685 | Stabilising | PRO | 0 | pnca_complex.pdb |
| 239 | A102V | A | 102 | V | A | PZA | 3.5 | -0.251 | Destabilising | -0.162 | Destabilising | -0.0648578811369509 | -0.0410334346504559 | A102 | AA102 | -1.90987 | -2.0 | -26.0 | 0.0 | 0.0 | -26.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -5.0 | 0.0 | -3.0 | -2.0 | -4.0 | 0.0 | -4.0 | -3.0 | -0.36719795431823427 | Stabilising | -1.389 | Destabilising | -0.23682864450127877 | 10 | 0.0775193798449612 | - | loop | 0.0333333333333332 | 5.51 | ALA | -0.862 | -0.7100494233937397 | 8 | 8 | -0.955 | -0.827 | 9:8 | 150/150 | M:E:S:G:A:H:Q | 73 | 0.7684210526315789 | 85 | effect | pnca_p.ala102val | 0.000646830530401 | 0.886301112240174 | 2.42613901795158 | 0.210089452509977 | 0.707162944655621 | 1.25331950569298 | 0.511701209936356 | 9.20262713399942 | 2.42613636363636 | 0.384915207210874 | 2.42593660187249 | 0.188417082130056 | 0.724879726073294 | 0.392299288705794 | 11.3662890368022 | 0.724684701500429 | 0.394611528192705 | -0.73 | -0.1910994764397905 | Destabilising | VAL | 0 | pnca_complex.pdb |
| 240 | A102R | A | 102 | R | A | PZA | 3.5 | -0.696 | Destabilising | 0.174 | Stabilising | -0.17984496124031 | 0.0780269058295964 | A102 | AA102 | 4.1344 | -76.0 | -30.0 | 0.0 | 0.0 | -30.0 | 0.0 | 0.0 | 0.0 | 0.0 | -2.0 | 0.0 | 0.0 | -2.0 | 0.0 | 0.0 | 0.0 | 0.0 | -12.0 | 0.0 | -4.0 | -10.0 | -16.0 | 0.0 | -12.0 | -7.0 | 0.15058384749306158 | Destabilising | -2.095 | Destabilising | -0.35720375106564367 | 10 | 0.0775193798449612 | - | loop | 0.0333333333333332 | 5.51 | ALA | -0.862 | -0.7100494233937397 | 8 | 8 | -0.955 | -0.827 | 9:8 | 150/150 | M:E:S:G:A:H:Q | 81 | 0.8526315789473684 | 91 | effect | pnca_p.ala102arg | 7.18700589334483e-05 | -8.98740878149642 | 0.0001249735077034 | 0.940032862253633 | 119.468044435492 | -0.0752285585987749 | 4692673.51081367 | 2.42412778478352 | 0.384555509373631 | 0.0 | 1.0 | 0.0 | 0.0 | 188.544222231268 | 1.0341007080334399e-29 | 0.999999999999997 | -0.28 | -0.0732984293193717 | Destabilising | ARG | 0 | pnca_complex.pdb | |
| 241 | Y103D | Y | 103 | D | A | PZA | 5.416 | 1.176 | Stabilising | 0.851 | Stabilising | 1.0 | 0.3816143497757847 | Y103 | YA103 | 1.18458 | 34.0 | -24.0 | 0.0 | 0.0 | -24.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.0 | 0.0 | -2.0 | 4.0 | -2.0 | 0.0 | -2.0 | -2.0 | 0.04314498211671122 | Destabilising | -0.578 | Destabilising | -0.09855072463768115 | 138 | 0.5247148288973384 | - | loop | -0.1 | 3.94 | TYR | -1.175 | -0.9678747940691929 | 9 | 9 | -1.221 | -1.152 | 9:9 | 150/150 | Y:K | 88 | 0.9263157894736842 | 91 | effect | pnca_p.tyr103asp | 0.0021561017680034 | 4.95817835126683 | 142.334276537658 | 1.0743991920355e-06 | 1.01654133277845 | 4.87749803317387 | 30.4620917601388 | 2537.05252258235 | 142.334468085106 | 2.1533100827021 | 142.74783870505 | 1.2391666921776101e-21 | 20.9068702685848 | 23.5556923218963 | 5610.51758528632 | 128.720903887203 | 7.80576752108032e-30 | 1.51 | 0.848314606741573 | Stabilising | ASP | 0 | pnca_complex.pdb |
| 242 | Y103C | Y | 103 | C | A | PZA | 5.416 | 0.606 | Stabilising | -0.48 | Destabilising | 0.5153061224489796 | -0.121580547112462 | Y103 | YA103 | 1.02924 | 42.0 | 4.0 | 0.0 | 0.0 | 4.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -2.0 | 2.0 | 0.0 | 0.0 | -2.0 | 0.0 | 0.03748716118270092 | Destabilising | -0.498 | Destabilising | -0.08491048593350384 | 138 | 0.5247148288973384 | - | loop | -0.1 | 3.94 | TYR | -1.175 | -0.9678747940691929 | 9 | 9 | -1.221 | -1.152 | 9:9 | 150/150 | Y:K | 68 | 0.7157894736842105 | 80 | effect | pnca_p.tyr103cys | 0.0007187005893344 | 1.17440310243918 | 3.23621068095208 | 0.0690022741521524 | 0.64584247435876 | 1.8184048728062 | 0.826804878959969 | 11.3377530375619 | 3.23621052631579 | 0.510036766167445 | 3.23583471755484 | 0.0754031320762053 | 1.12261061414134 | 0.671078964694216 | 13.6617156135614 | 2.2626260572101 | 0.132529157572648 | 1.43 | 0.8033707865168539 | Stabilising | CYS | 0 | pnca_complex.pdb |
| 243 | Y103S | Y | 103 | S | A | PZA | 5.416 | 0.233 | Stabilising | -0.062 | Destabilising | 0.1981292517006803 | -0.0157041540020263 | Y103 | YA103 | 1.16175 | 44.0 | 4.0 | 0.0 | 0.0 | 4.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 4.0 | 0.0 | 0.0 | 4.0 | 2.0 | 0.0 | 0.0 | 2.0 | 0.04231346382185185 | Destabilising | -0.796 | Destabilising | -0.13572037510656437 | 138 | 0.5247148288973384 | - | loop | -0.1 | 3.94 | TYR | -1.175 | -0.9678747940691929 | 9 | 9 | -1.221 | -1.152 | 9:9 | 150/150 | Y:K | 85 | 0.8947368421052632 | 91 | effect | pnca_p.tyr103ser | 7.18700589334483e-05 | 12.1451538387267 | 188179.926264673 | 0.919026337424241 | 119.468044436244 | 0.101660271548247 | 5.01153666061564e-06 | 9.70142977291842 | 0.986835744238421 | inf | 0.170978870202674 | 0.767057556984365 | 0.124324963210678 | inf | 0.763784339928386 | 0.382146811758261 | 0.42 | 0.2359550561797752 | Stabilising | SER | 0 | pnca_complex.pdb | |
| 244 | Y103H | Y | 103 | H | A | PZA | 5.416 | 0.779 | Stabilising | -0.046 | Destabilising | 0.6624149659863946 | -0.0116514690982776 | Y103 | YA103 | 0.909501 | 22.0 | -22.0 | 0.0 | 0.0 | -22.0 | 0.0 | 0.0 | 0.0 | 0.0 | -2.0 | 0.0 | -2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 3.0 | 0.0 | -1.0 | 4.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0331260061626323 | Destabilising | -0.683 | Destabilising | -0.1164535379369139 | 138 | 0.5247148288973384 | - | loop | -0.1 | 3.94 | TYR | -1.175 | -0.9678747940691929 | 9 | 9 | -1.221 | -1.152 | 9:9 | 150/150 | Y:K | 81 | 0.8526315789473684 | 91 | effect | pnca_p.tyr103his | 0.0001437401178668 | 13.1456002256202 | 511754.463552419 | 0.924803768446986 | 139.27718332654 | 0.0943844491369405 | 0.0001628371344458 | 19.411022297013 | 1.28804840845689 | inf | 0.0292235860951597 | 1.53426649183163 | 0.91081598550184 | inf | 4.73122070382274 | 0.0296198560706035 | 1.21 | 0.6797752808988764 | Stabilising | HIS | 0 | pnca_complex.pdb | |
| 245 | S104R | S | 104 | R | A | PZA | 6.519 | -0.525 | Destabilising | -0.4379999999999999 | Destabilising | -0.1356589147286821 | -0.1109422492401215 | S104 | SA104 | -0.736092 | -68.0 | -30.0 | 0.0 | 0.0 | -30.0 | 0.0 | 0.0 | 0.0 | 0.0 | 4.0 | 0.0 | 0.0 | 4.0 | 0.0 | 0.0 | 0.0 | 0.0 | -8.0 | 0.0 | -4.0 | -9.0 | -2.0 | 0.0 | -4.0 | -2.0 | -0.14152349457817426 | Stabilising | -2.325 | Destabilising | -0.39641943734015345 | 1 | 0.0064516129032258 | - | loop | -0.8333333333333334 | 5.37 | SER | -1.214 | -1.0 | 9 | 9 | -1.229 | -1.201 | 9:9 | 150/150 | S | 85 | 0.8947368421052632 | 91 | effect | pnca_p.ser104arg | 0.0005749604714675 | 2.6796663501904 | 14.5802277940117 | 0.0010245352377103 | 0.816050632122416 | 3.28370108999367 | 3.35697961122126 | 99.5538692592611 | 14.5802781289507 | 1.16376580853041 | 14.5801759034061 | 0.0005075351447614 | 3.29453387923245 | 2.60435121163486 | 147.676327006136 | 15.0663448164144 | 0.0001037975122989 | -0.47 | -0.1230366492146596 | Destabilising | ARG | 0 | pnca_complex.pdb |
| 246 | S104G | S | 104 | G | A | PZA | 6.519 | -0.6709999999999999 | Destabilising | -0.7 | Destabilising | -0.1733850129198966 | -0.177304964539007 | S104 | SA104 | 3.32695 | 4.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 4.0 | 0.0 | 2.0 | 2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 1.0 | 0.0 | 1.0 | 0.0 | 2.0 | 0.0 | 5.0 | 15.0 | 0.12117476088840974 | Destabilising | -2.163 | Destabilising | -0.36879795396419435 | 1 | 0.0064516129032258 | - | loop | -0.8333333333333334 | 5.37 | SER | -1.214 | -1.0 | 9 | 9 | -1.229 | -1.201 | 9:9 | 150/150 | S | 81 | 0.8526315789473684 | 91 | effect | pnca_p.ser104gly | 0.0002156101768003 | 0.885806606247283 | 2.42493957425811 | 0.469406216824825 | 1.22442753211922 | 0.723445514749363 | 0.112662937620391 | 25.327054747104 | 2.42493692178301 | 0.384700446081433 | 2.42473736947533 | 0.430258985168156 | 0.366270051463612 | 0.0410854444106247 | 46.5881472867033 | 4.31445715363782e-25 | 0.999999999999476 | -0.68 | -0.1780104712041885 | Destabilising | GLY | 0 | pnca_complex.pdb |
| 247 | S104I | S | 104 | I | A | PZA | 6.519 | 0.284 | Stabilising | -0.295 | Destabilising | 0.2414965986394557 | -0.0747213779128672 | S104 | SA104 | 0.982352 | -18.0 | 2.0 | 0.0 | 0.0 | 2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.0 | 0.0 | 0.0 | 2.0 | 0.0 | 0.0 | 0.0 | 0.0 | -7.0 | 0.0 | -11.0 | 0.0 | -10.0 | 0.0 | -6.0 | -6.0 | 0.03577939815995163 | Destabilising | -1.713 | Destabilising | -0.2920716112531969 | 1 | 0.0064516129032258 | - | loop | -0.8333333333333334 | 5.37 | SER | -1.214 | -1.0 | 9 | 9 | -1.229 | -1.201 | 9:9 | 150/150 | S | 82 | 0.8631578947368421 | 91 | effect | -0.39 | -0.1020942408376963 | Destabilising | ILE | 0 | pnca_complex.pdb | ||||||||||||||||||
| 248 | G105R | G | 105 | R | A | PZA | 7.858 | -0.974 | Destabilising | -0.634 | Destabilising | -0.2516795865633075 | -0.1605876393110435 | G105 | GA105 | 5.20362 | -98.0 | -50.0 | 0.0 | -2.0 | -48.0 | 0.0 | 0.0 | 0.0 | 0.0 | -4.0 | 0.0 | 0.0 | -4.0 | 0.0 | 0.0 | 0.0 | 0.0 | -23.0 | 0.0 | -8.0 | -21.0 | -22.0 | 0.0 | -27.0 | -39.0 | 0.1895271673016266 | Destabilising | -1.727 | Destabilising | -0.294458653026428 | 0 | 0.0 | G | helix | 0.5333333333333332 | 7.04 | GLY | -0.506 | -0.4168039538714992 | 7 | 7 | -0.674 | -0.411 | 7:7 | 150/150 | A:S:M:G:I:V:L | 81 | 0.8526315789473684 | 91 | effect | pnca_p.gly105arg | 7.18700589334483e-05 | 12.1451538387267 | 188179.926264685 | 0.919026337424243 | 119.468044436248 | 0.101660271548245 | 5.01153666061226e-06 | 9.70142977291842 | 0.986835744238421 | inf | 0.170978870202674 | 0.767057556984365 | 0.124324963210678 | inf | 0.763784339928386 | 0.382146811758261 | -0.66 | -0.1727748691099476 | Destabilising | ARG | 0 | pnca_complex.pdb | |
| 249 | G105V | G | 105 | V | A | PZA | 7.858 | 0.1169999999999999 | Stabilising | -0.85 | Destabilising | 0.0994897959183673 | -0.2152988855116514 | G105 | GA105 | -2.03856 | -2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -2.0 | 0.0 | -2.0 | 2.0 | 0.0 | 0.0 | 0.0 | 0.0 | -9.0 | 0.0 | -1.0 | -10.0 | -8.0 | 0.0 | -9.0 | -21.0 | -0.39194032146427743 | Stabilising | -1.183 | Destabilising | -0.20170502983802216 | 0 | 0.0 | G | helix | 0.5333333333333332 | 7.04 | GLY | -0.506 | -0.4168039538714992 | 7 | 7 | -0.674 | -0.411 | 7:7 | 150/150 | A:S:M:G:I:V:L | 68 | 0.7157894736842105 | 80 | effect | pnca_p.gly105val | 7.18700589334483e-05 | 12.1451538387264 | 188179.926264631 | 0.919026337424233 | 119.468044436231 | 0.101660271548256 | 5.01153666062796e-06 | 9.70142977291842 | 0.986835744238421 | inf | 0.170978870202674 | 0.767057556984365 | 0.124324963210678 | inf | 0.763784339928386 | 0.382146811758261 | -0.86 | -0.225130890052356 | Destabilising | VAL | 0 | pnca_complex.pdb | |
| 250 | G105D | G | 105 | D | A | PZA | 7.858 | -1.651 | Destabilising | 0.7090000000000001 | Stabilising | -0.4266149870801033 | 0.3179372197309417 | G105 | GA105 | 2.15123 | -20.0 | -32.0 | 0.0 | 0.0 | -32.0 | 0.0 | 0.0 | 0.0 | 0.0 | -2.0 | 0.0 | 2.0 | -2.0 | 0.0 | 0.0 | 0.0 | 0.0 | -5.0 | 0.0 | 0.0 | -5.0 | -18.0 | 0.0 | -15.0 | -25.0 | 0.07835247925757034 | Destabilising | -2.29 | Destabilising | -0.39045183290707586 | 0 | 0.0 | G | helix | 0.5333333333333332 | 7.04 | GLY | -0.506 | -0.4168039538714992 | 7 | 7 | -0.674 | -0.411 | 7:7 | 150/150 | A:S:M:G:I:V:L | 79 | 0.8315789473684211 | 85 | effect | pnca_p.gly105asp | 0.0001437401178668 | 13.1456002256223 | 511754.463553489 | 0.924803768447052 | 139.277183326685 | 0.0943844491368573 | 0.0001628371344425 | 19.411022297013 | 1.28804840845689 | inf | 0.0292235860951597 | 1.53426649183163 | 0.91081598550184 | inf | 4.73122070382274 | 0.0296198560706035 | -1.54 | -0.4031413612565445 | Destabilising | ASP | 0 | pnca_complex.pdb | |
| 251 | F106S | F | 106 | S | A | PZA | 10.466 | -2.455 | Destabilising | -0.439 | Destabilising | -0.6343669250645995 | -0.1111955420466058 | F106 | FA106 | 4.863980000000001 | 32.0 | 2.0 | 0.0 | 0.0 | 2.0 | 0.0 | 0.0 | 0.0 | 0.0 | -2.0 | 0.0 | -2.0 | -4.0 | 0.0 | 0.0 | 0.0 | 0.0 | 8.0 | 0.0 | 4.0 | 5.0 | 6.0 | 0.0 | -2.0 | 6.0 | 0.1771567391953613 | Destabilising | -1.914 | Destabilising | -0.32634271099744244 | 29 | 0.1208333333333333 | G | helix | -0.3666666666666667 | 5.05 | PHE | -1.174 | -0.9670510708401977 | 9 | 9 | -1.221 | -1.152 | 9:9 | 150/150 | F:L | 73 | 0.7684210526315789 | 85 | effect | pnca_p.phe106ser | 7.18700589334483e-05 | 12.1451538387255 | 188179.926264447 | 0.9190263374242 | 119.468044436172 | 0.101660271548299 | 5.01153666068353e-06 | 9.70142977291842 | 0.986835744238421 | inf | 0.170978870202674 | 0.767057556984365 | 0.124324963210678 | inf | 0.763784339928386 | 0.382146811758261 | -2.08 | -0.5445026178010471 | Destabilising | SER | 0 | pnca_complex.pdb | |
| 252 | F106C | F | 106 | C | A | PZA | 10.466 | -1.594 | Destabilising | -1.068 | Destabilising | -0.4118863049095607 | -0.270516717325228 | F106 | FA106 | 3.977 | 30.0 | -2.0 | 0.0 | 0.0 | -2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -2.0 | -2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 8.0 | 0.0 | 7.0 | 2.0 | 10.0 | 0.0 | 2.0 | 12.0 | 0.14485099687497724 | Destabilising | -1.577 | Destabilising | -0.26888320545609545 | 29 | 0.1208333333333333 | G | helix | -0.3666666666666667 | 5.05 | PHE | -1.174 | -0.9670510708401977 | 9 | 9 | -1.221 | -1.152 | 9:9 | 150/150 | F:L | 59 | 0.6210526315789474 | 75 | effect | pnca_p.phe106cys | 7.18700589334483e-05 | -8.98740878149641 | 0.0001249735077034 | 0.940032862253633 | 119.468044435491 | -0.0752285585987749 | 4692673.51081193 | 2.42412778478352 | 0.384555509373631 | 0.0 | 1.0 | 0.0 | 0.0 | 188.544222231268 | 1.0341007080334399e-29 | 0.999999999999997 | -2.12 | -0.5549738219895288 | Destabilising | CYS | 0 | pnca_complex.pdb | |
| 253 | F106V | F | 106 | V | A | PZA | 10.466 | -1.933 | Destabilising | -1.625 | Destabilising | -0.4994832041343669 | -0.4116008105369808 | F106 | FA106 | 3.73767 | 30.0 | 4.0 | 0.0 | 0.0 | 4.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 6.0 | 0.0 | 4.0 | 3.0 | 10.0 | 0.0 | 2.0 | 8.0 | 0.13613407731699678 | Destabilising | -2.02 | Destabilising | -0.3444160272804774 | 29 | 0.1208333333333333 | G | helix | -0.3666666666666667 | 5.05 | PHE | -1.174 | -0.9670510708401977 | 9 | 9 | -1.221 | -1.152 | 9:9 | 150/150 | F:L | 69 | 0.7263157894736842 | 80 | effect | pnca_p.phe106val | 7.18700589334483e-05 | 12.1451538387261 | 188179.926264574 | 0.919026337424223 | 119.468044436213 | 0.101660271548269 | 5.01153666064512e-06 | 9.70142977291842 | 0.986835744238421 | inf | 0.170978870202674 | 0.767057556984365 | 0.124324963210678 | inf | 0.763784339928386 | 0.382146811758261 | -2.1 | -0.549738219895288 | Destabilising | VAL | 0 | pnca_complex.pdb | |
| 254 | F106L | F | 106 | L | A | PZA | 10.466 | -1.425 | Destabilising | -1.7080000000000002 | Destabilising | -0.3682170542635659 | -0.4326241134751774 | F106 | FA106 | 1.92858 | 10.0 | 4.0 | 0.0 | 0.0 | 4.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.0 | 0.0 | 0.0 | 2.0 | 6.0 | 0.0 | 2.0 | 4.0 | 0.07024308160752919 | Destabilising | -0.947 | Destabilising | -0.16146632566069904 | 29 | 0.1208333333333333 | G | helix | -0.3666666666666667 | 5.05 | PHE | -1.174 | -0.9670510708401977 | 9 | 9 | -1.221 | -1.152 | 9:9 | 150/150 | F:L | 66 | 0.6947368421052632 | 80 | effect | pnca_p.phe106leu | 0.0002156101768003 | 0.885806606247283 | 2.42493957425811 | 0.469406216824826 | 1.22442753211922 | 0.723445514749363 | 0.112662937620387 | 25.3270547471038 | 2.42493692178301 | 0.384700446081433 | 2.42473736947533 | 0.430258985168156 | 0.366270051463612 | 0.0410854444106247 | 46.5881472867033 | 4.31445715363782e-25 | 0.999999999999476 | -1.96 | -0.5130890052356021 | Destabilising | LEU | 0 | pnca_complex.pdb |
| 255 | E107D | E | 107 | D | A | PZA | 8.13 | -0.2239999999999999 | Destabilising | -0.6559999999999999 | Destabilising | -0.0578811369509043 | -0.166160081053698 | E107 | EA107 | 0.965668 | 14.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -2.0 | 0.0 | -2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 3.0 | 0.0 | -1.0 | 4.0 | -6.0 | 0.0 | -4.0 | -4.0 | 0.03517173056330539 | Destabilising | -0.917 | Destabilising | -0.15635123614663257 | 88 | 0.3946188340807174 | G | helix | -0.3666666666666667 | 3.69 | GLU | -0.068 | -0.05601317957166393 | 5 | 5 | -0.244 | 0.083 | 6:5 | 150/150 | T:S:G:A:M:D:Q:F:H:Y:E:R:V:L | 7 | 0.07368421052631578 | 53 | effect | -0.02 | -0.0052356020942408 | Destabilising | ASP | 0 | pnca_complex.pdb | ||||||||||||||||||
| 256 | G108R | G | 108 | R | A | PZA | 10.939 | -0.972 | Destabilising | -1.199 | Destabilising | -0.2511627906976744 | -0.3036980749746707 | G108 | GA108 | 8.65723 | -90.0 | -46.0 | 0.0 | 0.0 | -46.0 | 0.0 | 0.0 | 0.0 | 0.0 | -4.0 | 0.0 | -2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -22.0 | 0.0 | -10.0 | -18.0 | -18.0 | 0.0 | -17.0 | -31.0 | 0.31531516109528773 | Destabilising | -2.025 | Destabilising | -0.34526854219948844 | 0 | 0.0 | - | loop | 0.1 | 5.18 | GLY | -0.947 | -0.7800658978583196 | 9 | 9 | -1.062 | -0.872 | 9:8 | 136/150 | N:V:D:G:E:A:P | 53 | 0.5578947368421052 | 75 | effect | pnca_p.gly108arg | 0.0002874802357337 | 1.57937329521209 | 4.85191414039983 | 0.114342297004303 | 1.0002536454007 | 1.57897279602454 | 0.581889091312071 | 40.456291107579 | 4.85191417753471 | 0.685913110299906 | 4.85118443551178 | 0.137954936368295 | 0.860262754777729 | 0.351471331417763 | 67.0421060419706 | 1.17497090855698 | 0.278382201819561 | -0.81 | -0.2120418848167539 | Destabilising | ARG | 0 | pnca_complex.pdb |
| 257 | G108E | G | 108 | E | A | PZA | 10.939 | -1.423 | Destabilising | 0.303 | Stabilising | -0.3677002583979328 | 0.1358744394618834 | G108 | GA108 | 3.72313 | -44.0 | -66.0 | 0.0 | 0.0 | -66.0 | 0.0 | 0.0 | 0.0 | 0.0 | -2.0 | 0.0 | -2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -13.0 | 0.0 | -8.0 | -9.0 | -12.0 | 0.0 | -15.0 | -23.0 | 0.1356044988672703 | Destabilising | -3.566 | Destabilising | -0.6080136402387041 | 0 | 0.0 | - | loop | 0.1 | 5.18 | GLY | -0.947 | -0.7800658978583196 | 9 | 9 | -1.062 | -0.872 | 9:8 | 136/150 | N:V:D:G:E:A:P | 39 | 0.4105263157894737 | 66 | effect | -0.78 | -0.2041884816753927 | Destabilising | GLU | 0 | pnca_complex.pdb | ||||||||||||||||||
| 258 | D110H | D | 110 | H | A | PZA | 16.281 | -0.7609999999999999 | Destabilising | -1.3 | Destabilising | -0.196640826873385 | -0.3292806484295846 | D110 | DA110 | 3.05477 | -10.0 | 20.0 | 0.0 | 0.0 | 20.0 | 0.0 | 0.0 | 0.0 | 0.0 | -2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -3.0 | 0.0 | -3.0 | -1.0 | 0.0 | 0.0 | 2.0 | 0.0 | 0.1112613728246855 | Destabilising | -0.614 | Destabilising | -0.10468883205456095 | 17 | 0.0880829015544041 | - | loop | -0.9333333333333332 | 4.81 | ASP | 0.526 | 0.1685897435897436 | 3 | 3 | 0.225 | 0.59 | 4:3 | 128/150 | Q:H:E:K:R:L:N:T:A:G:S:D | -18 | -0.1935483870967742 | 57 | neutral | -0.26 | -0.0680628272251308 | Destabilising | HIS | 0 | pnca_complex.pdb | ||||||||||||||||||
| 259 | E111D | E | 111 | D | A | PZA | 18.382 | 0.156 | Stabilising | 0.103 | Stabilising | 0.1326530612244898 | 0.0461883408071748 | E111 | EA111 | 0.183196 | 10.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 1.0 | 0.0 | 1.0 | 1.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.006672397089139635 | Destabilising | -0.053 | Destabilising | -0.009036658141517476 | 167 | 0.7488789237668162 | S | loop | -3.5 | 3.55 | GLU | 1.616 | 0.517948717948718 | 1 | 1 | 1.183 | 1.712 | 1:1 | 132/150 | T:M:S:G:A:P:D:F:E:Q:L:V:N:R:K | -55 | -0.5913978494623656 | 78 | neutral | pnca_p.glu111asp | 7.18700589334483e-05 | -8.98740878149641 | 0.0001249735077034 | 0.940032862253633 | 119.46804443549 | -0.0752285585987759 | 4692673.51081035 | 2.42412778478352 | 0.384555509373631 | 0.0 | 1.0 | 0.0 | 0.0 | 188.544222231268 | 1.0341007080334399e-29 | 0.999999999999997 | -0.32 | -0.0837696335078534 | Destabilising | ASP | 0 | pnca_complex.pdb | |
| 260 | N112Y | N | 112 | Y | A | PZA | 19.93 | -0.3779999999999999 | Destabilising | -0.261 | Destabilising | -0.0976744186046511 | -0.0661094224924012 | N112 | NA112 | 4.97901 | -10.0 | 2.0 | 0.0 | 0.0 | 2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.0 | 0.0 | 2.0 | 4.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.0 | 1.0 | 4.0 | 0.0 | 0.0 | 4.0 | 0.1813463821851849 | Destabilising | -0.297 | Destabilising | -0.050639386189258305 | 109 | 0.558974358974359 | S | loop | -2.466666666666667 | 3.54 | ASN | 0.77 | 0.24679487179487178 | 2 | 2 | 0.389 | 0.842 | 4:2 | 131/150 | K:R:N:V:Q:E:H:D:P:S:M:G:A:T | 26 | 0.2736842105263158 | 63 | effect | -0.25 | -0.0654450261780104 | Destabilising | TYR | 0 | pnca_complex.pdb | ||||||||||||||||||
| 261 | T114M | T | 114 | M | A | PZA | 17.491 | 0.246 | Stabilising | -1.152 | Destabilising | 0.2091836734693878 | -0.2917933130699088 | T114 | TA114 | -0.0405939 | -8.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -2.0 | 0.0 | -2.0 | 2.0 | 0.0 | 0.0 | 0.0 | 0.0 | -6.0 | 0.0 | 0.0 | -6.0 | 0.0 | 0.0 | 0.0 | 2.0 | -0.007804718141967239 | Stabilising | -0.077 | Destabilising | -0.013128729752770673 | 29 | 0.1686046511627907 | - | loop | -0.9 | 4.57 | THR | -0.224 | -0.18451400329489293 | 6 | 6 | -0.411 | -0.147 | 7:6 | 148/150 | S:A:P:D:H:K:T:W:E:Q:V:N:L:I:R:C | 25 | 0.2631578947368421 | 63 | effect | pnca_p.thr114met | 7.18700589334483e-05 | -8.98740878149641 | 0.0001249735077034 | 0.940032862253633 | 119.468044435491 | -0.0752285585987751 | 4692673.51081327 | 2.42412778478352 | 0.384555509373631 | 0.0 | 1.0 | 0.0 | 0.0 | 188.544222231268 | 1.0341007080334399e-29 | 0.999999999999997 | 0.38 | 0.2134831460674157 | Stabilising | MET | 0 | pnca_complex.pdb | |
| 262 | T114P | T | 114 | P | A | PZA | 17.491 | -0.6509999999999999 | Destabilising | -1.3219999999999998 | Destabilising | -0.1682170542635658 | -0.3348530901722391 | T114 | TA114 | 5.39158 | 4.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 4.0 | 0.0 | 0.0 | 0.0 | 0.0 | -2.0 | 2.0 | -4.0 | 0.0 | 4.0 | 0.0 | -2.0 | 6.0 | 0.19637307964073167 | Destabilising | -2.268 | Destabilising | -0.38670076726342706 | 29 | 0.1686046511627907 | - | loop | -0.9 | 4.57 | THR | -0.224 | -0.18451400329489293 | 6 | 6 | -0.411 | -0.147 | 7:6 | 148/150 | S:A:P:D:H:K:T:W:E:Q:V:N:L:I:R:C | 34 | 0.35789473684210527 | 66 | effect | pnca_p.thr114pro | 7.18700589334483e-05 | 12.1451538387266 | 188179.926264667 | 0.91902633742424 | 119.468044436242 | 0.101660271548248 | 5.01153666061746e-06 | 9.70142977291842 | 0.986835744238421 | inf | 0.170978870202674 | 0.767057556984365 | 0.124324963210678 | inf | 0.763784339928386 | 0.382146811758261 | -0.1 | -0.0261780104712041 | Destabilising | PRO | 0 | pnca_complex.pdb | |
| 263 | P115L | P | 115 | L | A | PZA | 16.985 | -0.4479999999999999 | Destabilising | -0.972 | Destabilising | -0.1157622739018087 | -0.2462006079027355 | P115 | PA115 | 0.979724 | -14.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -2.0 | 0.0 | -2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -8.0 | 0.0 | -4.0 | -5.0 | -2.0 | 0.0 | -2.0 | 0.0 | 0.03568368067949213 | Destabilising | -0.8 | Destabilising | -0.13640238704177324 | 50 | 0.3144654088050314 | B | strand | 0.4999999999999998 | 4.3 | PRO | 0.774 | 0.24807692307692308 | 2 | 2 | 0.389 | 0.842 | 4:2 | 147/150 | T:G:A:S:P:D:E:Q:L:N:K:R | 8 | 0.08421052631578947 | 53 | effect | pnca_p.pro115leu | 7.18700589334483e-05 | -8.98740878149641 | 0.0001249735077034 | 0.940032862253632 | 119.46804443549 | -0.0752285585987761 | 4692673.51081015 | 2.42412778478352 | 0.384555509373631 | 0.0 | 1.0 | 0.0 | 0.0 | 188.544222231268 | 1.0341007080334399e-29 | 0.999999999999997 | -0.55 | -0.143979057591623 | Destabilising | LEU | 0 | pnca_complex.pdb | |
| 264 | L116V | L | 116 | V | A | PZA | 13.071 | -1.084 | Destabilising | -1.648 | Destabilising | -0.2801033591731266 | -0.4174265450861196 | L116 | LA116 | 1.87491 | 20.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.0 | 0.0 | 2.0 | 0.0 | 2.0 | 0.0 | 0.0 | 2.0 | 0.06828830338216334 | Destabilising | -1.706 | Destabilising | -0.2908780903665814 | 0 | 0.0 | H | helix | 2.0 | 6.86 | LEU | -0.924 | -0.7611202635914334 | 8 | 8 | -1.028 | -0.872 | 9:8 | 147/150 | I:V:L:M:A:T:F | 48 | 0.5052631578947369 | 71 | effect | pnca_p.leu116val | 7.18700589334483e-05 | -8.98740878149641 | 0.0001249735077034 | 0.940032862253634 | 119.468044435492 | -0.0752285585987746 | 4692673.510814 | 2.42412778478352 | 0.384555509373631 | 0.0 | 1.0 | 0.0 | 0.0 | 188.544222231268 | 1.0341007080334399e-29 | 0.999999999999997 | 0.62 | 0.348314606741573 | Stabilising | VAL | 0 | pnca_complex.pdb | |
| 265 | L116R | L | 116 | R | A | PZA | 13.071 | -1.733 | Destabilising | -0.78 | Destabilising | -0.4478036175710594 | -0.1975683890577507 | L116 | LA116 | 4.65552 | -54.0 | -52.0 | 0.0 | -2.0 | -50.0 | 0.0 | 0.0 | 0.0 | 0.0 | -2.0 | 0.0 | -2.0 | -2.0 | 0.0 | 0.0 | 0.0 | 0.0 | -6.0 | 0.0 | 1.0 | -7.0 | -4.0 | 0.0 | -12.0 | 0.0 | 0.16956417223318934 | Destabilising | -4.189 | Destabilising | -0.7142369991474851 | 0 | 0.0 | H | helix | 2.0 | 6.86 | LEU | -0.924 | -0.7611202635914334 | 8 | 8 | -1.028 | -0.872 | 9:8 | 147/150 | I:V:L:M:A:T:F | 85 | 0.8947368421052632 | 91 | effect | pnca_p.leu116arg | 7.18700589334483e-05 | 12.1451538387266 | 188179.926264668 | 0.91902633742424 | 119.468044436243 | 0.101660271548248 | 5.01153666061721e-06 | 9.70142977291842 | 0.986835744238421 | inf | 0.170978870202674 | 0.767057556984365 | 0.124324963210678 | inf | 0.763784339928386 | 0.382146811758261 | -1.89 | -0.4947643979057591 | Destabilising | ARG | 0 | pnca_complex.pdb | |
| 266 | L116P | L | 116 | P | A | PZA | 13.071 | -1.386 | Destabilising | -1.504 | Destabilising | -0.3581395348837209 | -0.3809523809523809 | L116 | LA116 | 3.74372 | 18.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.0 | 2.0 | -2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -3.0 | 2.0 | -3.0 | -2.0 | 8.0 | 0.0 | 0.0 | 8.0 | 0.13635443148624335 | Destabilising | -2.595 | Destabilising | -0.4424552429667519 | 0 | 0.0 | H | helix | 2.0 | 6.86 | LEU | -0.924 | -0.7611202635914334 | 8 | 8 | -1.028 | -0.872 | 9:8 | 147/150 | I:V:L:M:A:T:F | 89 | 0.9368421052631579 | 91 | effect | pnca_p.leu116pro | 0.0002156101768003 | 2.27260607808816 | 9.70465898653047 | 0.0634455902260904 | 1.22442760158496 | 1.8560559033024 | 0.929172866365899 | 208.881603004966 | 9.70466975178797 | 0.986980761010679 | 9.70194990589383 | 0.0776844925942494 | 1.10966566656461 | 0.504888890842109 | 570.372842410328 | 2.29168245016684 | 0.130068862702538 | 0.06 | 0.0337078651685393 | Stabilising | PRO | 0 | pnca_complex.pdb |
| 267 | L117R | L | 117 | R | A | PZA | 17.11 | -0.6779999999999999 | Destabilising | -0.585 | Destabilising | -0.1751937984496124 | -0.148176291793313 | L117 | LA117 | 0.0947913 | -28.0 | -26.0 | 0.0 | -2.0 | -24.0 | 0.0 | 0.0 | 0.0 | 0.0 | -2.0 | 0.0 | -2.0 | -2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 4.0 | 0.0 | 1.0 | 4.0 | 2.0 | 0.0 | 2.0 | 0.0 | 0.0034525054815375982 | Destabilising | -1.884 | Destabilising | -0.3212276214833759 | 50 | 0.2487562189054726 | H | helix | 1.3666666666666665 | 4.46 | LEU | 0.447 | 0.14326923076923076 | 3 | 3 | 0.083 | 0.59 | 5:3 | 147/150 | D:P:G:S:A:T:K:V:L:E:H | 9 | 0.09473684210526316 | 53 | effect | pnca_p.leu117arg | 7.18700589334483e-05 | -8.98740878149642 | 0.0001249735077034 | 0.940032862253633 | 119.468044435491 | -0.0752285585987753 | 4692673.51081308 | 2.42412778478352 | 0.384555509373631 | 0.0 | 1.0 | 0.0 | 0.0 | 188.544222231268 | 1.0341007080334399e-29 | 0.999999999999997 | -0.23 | -0.0602094240837696 | Destabilising | ARG | 0 | pnca_complex.pdb | |
| 268 | N118E | N | 118 | E | A | PZA | 19.738 | 0.78 | Stabilising | -0.713 | Destabilising | 0.663265306122449 | -0.1805977710233029 | N118 | NA118 | -2.32726 | -6.0 | -14.0 | 0.0 | 0.0 | -14.0 | 0.0 | 0.0 | 0.0 | 0.0 | -2.0 | 0.0 | 0.0 | -4.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -2.0 | -2.0 | 0.0 | 0.0 | 0.0 | -0.447446743059294 | Stabilising | 0.371 | Stabilising | 0.3133445945945946 | 80 | 0.4102564102564102 | H | helix | -0.2 | 4.06 | ASN | 0.692 | 0.22179487179487178 | 2 | 2 | 0.389 | 0.842 | 4:2 | 146/150 | N:R:K:E:Y:Q:D:A:M:S:G:T | -29 | -0.3118279569892473 | 61 | neutral | -0.19 | -0.0497382198952879 | Destabilising | GLU | 0 | pnca_complex.pdb | ||||||||||||||||||
| 269 | W119C | W | 119 | C | A | PZA | 19.722 | -1.743 | Destabilising | -1.4980000000000002 | Destabilising | -0.4503875968992248 | -0.3794326241134752 | W119 | WA119 | 4.0665 | 42.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -2.0 | 0.0 | -2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 3.0 | 0.0 | -1.0 | 4.0 | 12.0 | 0.0 | 10.0 | 10.0 | 0.14811078169275707 | Destabilising | -2.343 | Destabilising | -0.39948849104859335 | 14 | 0.0491228070175438 | H | helix | -0.2 | 5.7 | TRP | 0.224 | 0.07179487179487179 | 4 | 4 | -0.038 | 0.389 | 5:4 | 146/150 | T:G:S:M:A:W:Q:F:E:Y:I:R:L:V | 48 | 0.5052631578947369 | 71 | effect | pnca_p.trp119cys | 7.18700589334483e-05 | 12.1451538387261 | 188179.926264578 | 0.919026337424224 | 119.468044436214 | 0.101660271548269 | 5.01153666064432e-06 | 9.70142977291842 | 0.986835744238421 | inf | 0.170978870202674 | 0.767057556984365 | 0.124324963210678 | inf | 0.763784339928386 | 0.382146811758261 | -1.91 | -0.5 | Destabilising | CYS | 0 | pnca_complex.pdb | |
| 270 | W119R | W | 119 | R | A | PZA | 19.722 | -1.874 | Destabilising | -0.807 | Destabilising | -0.4842377260981912 | -0.2044072948328267 | W119 | WA119 | 3.612130000000001 | -4.0 | -30.0 | 0.0 | -2.0 | -28.0 | 0.0 | 0.0 | 0.0 | 0.0 | -2.0 | 0.0 | 0.0 | -2.0 | 0.0 | 0.0 | 0.0 | 0.0 | -2.0 | 0.0 | -5.0 | -1.0 | 0.0 | 0.0 | 2.0 | 0.0 | 0.1315616372496886 | Destabilising | -2.916 | Destabilising | -0.4971867007672634 | 14 | 0.0491228070175438 | H | helix | -0.2 | 5.7 | TRP | 0.224 | 0.07179487179487179 | 4 | 4 | -0.038 | 0.389 | 5:4 | 146/150 | T:G:S:M:A:W:Q:F:E:Y:I:R:L:V | 70 | 0.7368421052631579 | 85 | effect | pnca_p.trp119arg | 0.0005030904125341 | 1.86781040138793 | 6.47410517670654 | 0.0145043045254536 | 0.764079088633846 | 2.44452495713176 | 1.4262375473788 | 32.8877353882417 | 6.47410526315789 | 0.811179756363585 | 6.47281975099898 | 0.0192724555107824 | 1.71506294819644 | 1.09429403734416 | 44.2397805449942 | 5.34879705543722 | 0.0207365726835135 | -1.89 | -0.4947643979057591 | Destabilising | ARG | 0 | pnca_complex.pdb |
| 271 | W119G | W | 119 | G | A | PZA | 19.722 | -2.983 | Destabilising | -1.84 | Destabilising | -0.7708010335917312 | -0.4660587639311044 | W119 | WA119 | 5.88168 | 52.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 5.0 | 0.0 | -3.0 | 6.0 | 18.0 | 0.0 | 15.0 | 31.0 | 0.21422358845854064 | Destabilising | -3.318 | Destabilising | -0.5657289002557545 | 14 | 0.0491228070175438 | H | helix | -0.2 | 5.7 | TRP | 0.224 | 0.07179487179487179 | 4 | 4 | -0.038 | 0.389 | 5:4 | 146/150 | T:G:S:M:A:W:Q:F:E:Y:I:R:L:V | 70 | 0.7368421052631579 | 85 | effect | pnca_p.trp119gly | 0.0001437401178668 | 13.1456002256201 | 511754.463552391 | 0.924803768446985 | 139.277183326538 | 0.0943844491369419 | 0.0001628371344459 | 19.411022297013 | 1.28804840845689 | inf | 0.0292235860951597 | 1.53426649183163 | 0.91081598550184 | inf | 4.73122070382274 | 0.0296198560706035 | -3.39 | -0.8874345549738221 | Destabilising | GLY | 0 | pnca_complex.pdb | |
| 272 | W119S | W | 119 | S | A | PZA | 19.722 | -3.136 | Destabilising | -0.995 | Destabilising | -0.8103359173126615 | -0.2520263424518744 | W119 | WA119 | 4.6385 | 44.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -2.0 | 0.0 | -2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 6.0 | 0.0 | 0.0 | 6.0 | 14.0 | 0.0 | 10.0 | 12.0 | 0.16894426678516014 | Destabilising | -2.258 | Destabilising | -0.38499573742540494 | 14 | 0.0491228070175438 | H | helix | -0.2 | 5.7 | TRP | 0.224 | 0.07179487179487179 | 4 | 4 | -0.038 | 0.389 | 5:4 | 146/150 | T:G:S:M:A:W:Q:F:E:Y:I:R:L:V | 66 | 0.6947368421052632 | 80 | effect | pnca_p.trp119ser | 0.0001437401178668 | 13.1456002256241 | 511754.463554449 | 0.924803768447112 | 139.277183326815 | 0.0943844491367826 | 0.0001628371344395 | 19.411022297013 | 1.28804840845689 | inf | 0.0292235860951597 | 1.53426649183163 | 0.91081598550184 | inf | 4.73122070382274 | 0.0296198560706035 | -3.44 | -0.9005235602094241 | Destabilising | SER | 0 | pnca_complex.pdb | |
| 273 | W119L | W | 119 | L | A | PZA | 19.722 | -1.981 | Destabilising | -2.11 | Destabilising | -0.5118863049095607 | -0.5344478216818642 | W119 | WA119 | 2.39227 | 22.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 1.0 | 0.0 | 1.0 | 1.0 | 12.0 | 0.0 | 6.0 | 8.0 | 0.08713168073776761 | Destabilising | -1.186 | Destabilising | -0.2022165387894288 | 14 | 0.0491228070175438 | H | helix | -0.2 | 5.7 | TRP | 0.224 | 0.07179487179487179 | 4 | 4 | -0.038 | 0.389 | 5:4 | 146/150 | T:G:S:M:A:W:Q:F:E:Y:I:R:L:V | 32 | 0.3368421052631579 | 66 | effect | -1.92 | -0.5026178010471204 | Destabilising | LEU | 0 | pnca_complex.pdb | ||||||||||||||||||
| 274 | L120P | L | 120 | P | A | PZA | 17.55 | -2.181 | Destabilising | -1.644 | Destabilising | -0.5635658914728682 | -0.4164133738601824 | L120 | LA120 | 7.59698 | 16.0 | 16.0 | 0.0 | 0.0 | 16.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.0 | 2.0 | 2.0 | -2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 4.0 | -4.0 | -2.0 | 8.0 | 0.0 | 2.0 | 4.0 | 0.2766985482120354 | Destabilising | -4.748 | Destabilising | -0.8095481670929241 | 0 | 0.0 | H | helix | -0.5333333333333335 | 8.07 | LEU | -1.142 | -0.9406919275123558 | 9 | 9 | -1.201 | -1.124 | 9:9 | 147/150 | F:V:L | 79 | 0.8315789473684211 | 85 | effect | pnca_p.leu120pro | 0.0018686215322696 | 15.1557612752458 | 3820001.12561286 | 0.885234541058746 | 105.002771503186 | 0.14433677376588 | 15316.7789340045 | 2.0462689242793896e+16 | 254.917127071823 | 2.40639901531589 | inf | 1.0165082312418301e-20 | 19.9928891002838 | 32.1173872780919 | inf | 120.509921037495 | 4.89215110948636e-28 | -1.51 | -0.3952879581151832 | Destabilising | PRO | 0 | pnca_complex.pdb |
| 275 | L120R | L | 120 | R | A | PZA | 17.55 | -2.51 | Destabilising | -0.772 | Destabilising | -0.648578811369509 | -0.1955420466058764 | L120 | LA120 | 5.6624 | -44.0 | -32.0 | 0.0 | -2.0 | -30.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -8.0 | 0.0 | 0.0 | -13.0 | -8.0 | 0.0 | -12.0 | -4.0 | 0.20623693354409633 | Destabilising | -4.716 | Destabilising | -0.8040920716112532 | 0 | 0.0 | H | helix | -0.5333333333333335 | 8.07 | LEU | -1.142 | -0.9406919275123558 | 9 | 9 | -1.201 | -1.124 | 9:9 | 147/150 | F:V:L | 74 | 0.7789473684210526 | 85 | effect | pnca_p.leu120arg | 0.0005030904125341 | 2.4969239337312 | 12.1450773794065 | 0.0028293218857323 | 0.83629495944555 | 2.98569769616526 | 2.61610833083038 | 84.8371270839259 | 12.1451137320977 | 1.08440158608155 | 12.1416664151504 | 0.0022516005975125 | 2.64750864476206 | 1.98635523014012 | 127.719946645636 | 11.0019205274607 | 0.0009101752788745 | -1.93 | -0.5052356020942408 | Destabilising | ARG | 0 | pnca_complex.pdb |
| 276 | R121W | R | 121 | W | A | PZA | 22.533 | -0.5379999999999999 | Destabilising | -0.426 | Destabilising | -0.1390180878552971 | -0.10790273556231 | R121 | RA121 | 1.95975 | 6.0 | 18.0 | 0.0 | 2.0 | 16.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.0 | 0.0 | 2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -4.0 | 0.0 | -6.0 | -2.0 | 0.07137836085635822 | Destabilising | -0.442 | Destabilising | -0.07536231884057971 | 125 | 0.4562043795620438 | H | helix | -1.4 | 3.76 | ARG | 0.506 | 0.1621794871794872 | 3 | 3 | 0.225 | 0.59 | 4:3 | 147/150 | D:T:A:S:G:L:N:C:R:K:I:H:E:Q | 70 | 0.7368421052631579 | 85 | effect | -0.5 | -0.1308900523560209 | Destabilising | TRP | 0 | pnca_complex.pdb | ||||||||||||||||||
| 277 | R121Q | R | 121 | Q | A | PZA | 22.533 | -0.1689999999999999 | Destabilising | -0.674 | Destabilising | -0.0436692506459948 | -0.1707193515704154 | R121 | RA121 | 1.41722 | 22.0 | 18.0 | 0.0 | 2.0 | 16.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -1.0 | 0.0 | 0.0 | -1.0 | -2.0 | 0.0 | -2.0 | 2.0 | 0.05161823731233473 | Destabilising | -0.286 | Destabilising | -0.048763853367433926 | 125 | 0.4562043795620438 | H | helix | -1.4 | 3.76 | ARG | 0.506 | 0.1621794871794872 | 3 | 3 | 0.225 | 0.59 | 4:3 | 147/150 | D:T:A:S:G:L:N:C:R:K:I:H:E:Q | 1 | 0.010526315789473684 | 53 | effect | pnca_p.arg121gln | 7.18700589334483e-05 | -8.98740878149641 | 0.0001249735077034 | 0.940032862253633 | 119.46804443549 | -0.0752285585987758 | 4692673.51080988 | 2.42412778478352 | 0.384555509373631 | 0.0 | 1.0 | 0.0 | 0.0 | 188.544222231268 | 1.0341007080334399e-29 | 0.999999999999997 | -0.53 | -0.1387434554973822 | Destabilising | GLN | 0 | pnca_complex.pdb | |
| 278 | R121P | R | 121 | P | A | PZA | 22.533 | -0.46 | Destabilising | -1.047 | Destabilising | -0.1188630490956072 | -0.2651975683890577 | R121 | RA121 | 4.90155 | 40.0 | 20.0 | 0.0 | 2.0 | 18.0 | 0.0 | 0.0 | 0.0 | 0.0 | 4.0 | 2.0 | 2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 4.0 | -3.0 | -2.0 | 4.0 | 0.0 | 4.0 | 0.0 | 0.1785251203752941 | Destabilising | -1.076 | Destabilising | -0.183461210571185 | 125 | 0.4562043795620438 | H | helix | -1.4 | 3.76 | ARG | 0.506 | 0.1621794871794872 | 3 | 3 | 0.225 | 0.59 | 4:3 | 147/150 | D:T:A:S:G:L:N:C:R:K:I:H:E:Q | 77 | 0.8105263157894737 | 85 | effect | pnca_p.arg121pro | 7.18700589334483e-05 | 12.1451538387264 | 188179.926264617 | 0.919026337424231 | 119.468044436227 | 0.101660271548259 | 5.01153666063191e-06 | 9.70142977291842 | 0.986835744238421 | inf | 0.170978870202674 | 0.767057556984365 | 0.124324963210678 | inf | 0.763784339928386 | 0.382146811758261 | -0.11 | -0.0287958115183246 | Destabilising | PRO | 0 | pnca_complex.pdb | |
| 279 | Q122R | Q | 122 | R | A | PZA | 24.683000000000003 | 0.113 | Stabilising | -0.114 | Destabilising | 0.0960884353741496 | -0.0288753799392097 | Q122 | QA122 | -1.69455 | -24.0 | -1.0 | 0.0 | 0.0 | -1.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.0 | 0.0 | -2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.0 | 0.0 | 3.0 | -1.0 | 2.0 | 0.0 | 0.0 | 2.0 | -0.3257998154272091 | Stabilising | -0.152 | Destabilising | -0.025916453537936913 | 132 | 0.5866666666666667 | T | loop | -4.166666666666667 | 3.49 | GLN | 1.334 | 0.4275641025641026 | 1 | 1 | 0.842 | 1.712 | 2:1 | 147/150 | D:T:S:M:A:G:K:R:N:Q:H:E:Y | -41 | -0.44086021505376344 | 72 | neutral | -0.16 | -0.0418848167539267 | Destabilising | ARG | 0 | pnca_complex.pdb | ||||||||||||||||||
| 280 | R123P | R | 123 | P | A | PZA | 23.59 | -0.348 | Destabilising | -0.955 | Destabilising | -0.089922480620155 | -0.2418946301925025 | R123 | RA123 | 3.5335300000000003 | 42.0 | 16.0 | 0.0 | 2.0 | 14.0 | 0.0 | 0.0 | 0.0 | 0.0 | 3.0 | 0.0 | 1.0 | 2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 4.0 | 2.0 | -2.0 | 0.0 | 6.0 | 0.0 | 2.0 | 4.0 | 0.12869885415831994 | Destabilising | -1.065 | Destabilising | -0.1815856777493606 | 98 | 0.3576642335766423 | T | loop | -2.8000000000000003 | 3.81 | ARG | 0.659 | 0.21121794871794872 | 3 | 3 | 0.389 | 0.842 | 4:2 | 147/150 | Q:H:F:Y:E:K:I:C:R:N:V:L:T:A:M | 54 | 0.5684210526315789 | 75 | effect | pnca_p.arg123pro | 0.0001437401178668 | 13.1456002256242 | 511754.463554485 | 0.924803768447114 | 139.27718332682 | 0.0943844491367796 | 0.0001628371344393 | 19.411022297013 | 1.28804840845689 | inf | 0.0292235860951597 | 1.53426649183163 | 0.91081598550184 | inf | 4.73122070382274 | 0.0296198560706035 | -0.23 | -0.0602094240837696 | Destabilising | PRO | 0 | pnca_complex.pdb | |
| 281 | R123G | R | 123 | G | A | PZA | 23.59 | -1.212 | Destabilising | -1.129 | Destabilising | -0.3131782945736434 | -0.28596757852077 | R123 | RA123 | 2.77078 | 50.0 | 16.0 | 0.0 | 2.0 | 14.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.0 | 0.0 | 0.0 | 2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 1.0 | 0.0 | 3.0 | -3.0 | 6.0 | 0.0 | 11.0 | 17.0 | 0.10091783885372124 | Destabilising | -1.005 | Destabilising | -0.1713554987212276 | 98 | 0.3576642335766423 | T | loop | -2.8000000000000003 | 3.81 | ARG | 0.659 | 0.21121794871794872 | 3 | 3 | 0.389 | 0.842 | 4:2 | 147/150 | Q:H:F:Y:E:K:I:C:R:N:V:L:T:A:M | 51 | 0.5368421052631579 | 75 | effect | -0.9 | -0.2356020942408377 | Destabilising | GLY | 0 | pnca_complex.pdb | ||||||||||||||||||
| 282 | G124R | G | 124 | R | A | PZA | 26.025 | -0.757 | Destabilising | -0.075 | Destabilising | -0.1956072351421188 | -0.0189969604863221 | G124 | GA124 | -0.489243 | -20.0 | -14.0 | 0.0 | -2.0 | -12.0 | 0.0 | 0.0 | 0.0 | 0.0 | -2.0 | 0.0 | 0.0 | -2.0 | 0.0 | 0.0 | 0.0 | 0.0 | -2.0 | 0.0 | -5.0 | -2.0 | 4.0 | 0.0 | -1.0 | 1.0 | -0.09406348534953472 | Stabilising | -0.439 | Destabilising | -0.07485080988917306 | 36 | 0.3461538461538461 | T | loop | -0.2333333333333332 | 3.58 | GLY | 1.071 | 0.3432692307692307 | 1 | 1 | 0.59 | 1.183 | 3:1 | 147/150 | A:S:G:D:Q:E:R:K:N | 28 | 0.29473684210526313 | 63 | effect | -0.47 | -0.1230366492146596 | Destabilising | ARG | 0 | pnca_complex.pdb | ||||||||||||||||||
| 283 | G124S | G | 124 | S | A | PZA | 26.025 | -1.24 | Destabilising | 0.612 | Stabilising | -0.3204134366925064 | 0.274439461883408 | G124 | GA124 | 1.1133 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -2.0 | 0.0 | -2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -1.0 | 0.0 | -3.0 | 0.0 | 0.0 | 0.0 | -3.0 | -9.0 | 0.04054880935904253 | Destabilising | -0.85 | Destabilising | -0.14492753623188404 | 36 | 0.3461538461538461 | T | loop | -0.2333333333333332 | 3.58 | GLY | 1.071 | 0.3432692307692307 | 1 | 1 | 0.59 | 1.183 | 3:1 | 147/150 | A:S:G:D:Q:E:R:K:N | -22 | -0.23655913978494625 | 61 | neutral | pnca_p.gly124ser | 7.18700589334483e-05 | -8.98740878149641 | 0.0001249735077034 | 0.940032862253633 | 119.46804443549 | -0.0752285585987759 | 4692673.51081215 | 2.42412778478352 | 0.384555509373631 | 0.0 | 1.0 | 0.0 | 0.0 | 188.544222231268 | 1.0341007080334399e-29 | 0.999999999999997 | -0.39 | -0.1020942408376963 | Destabilising | SER | 0 | pnca_complex.pdb | |
| 284 | V125G | V | 125 | G | A | PZA | 21.367 | -3.005 | Destabilising | -1.814 | Destabilising | -0.7764857881136951 | -0.4594731509625127 | V125 | VA125 | 3.83404 | 8.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -2.0 | 0.0 | -1.0 | 0.0 | 8.0 | 0.0 | 13.0 | 21.0 | 0.13964408248894586 | Destabilising | -3.24 | Destabilising | -0.5524296675191817 | 0 | 0.0 | - | loop | 0.1 | 6.12 | VAL | -0.095 | -0.07825370675453049 | 5 | 5 | -0.332 | -0.038 | 6:5 | 147/150 | I:L:V:Q:F:A:E | 70 | 0.7368421052631579 | 85 | effect | pnca_p.val125gly | 0.0031622825930717 | 4.21078388085649 | 67.4093600119011 | 1.83664466117051e-12 | 0.597583217500306 | 7.04635564979589 | 24.5112444006964 | 278.636893097378 | 67.409751924722 | 1.82872272889042 | 67.3855171102593 | 2.05851007546474e-28 | 27.6864470029886 | 21.4729050424094 | 338.090551978209 | 174.918303180059 | 6.238026108181269e-40 | -2.63 | -0.6884816753926701 | Destabilising | GLY | 0 | pnca_complex.pdb |
| 285 | V125D | V | 125 | D | A | PZA | 21.367 | -3.013 | Destabilising | -0.358 | Destabilising | -0.7785529715762274 | -0.0906788247213779 | V125 | VA125 | 3.9883 | -8.0 | -32.0 | 0.0 | -2.0 | -30.0 | 0.0 | 0.0 | 0.0 | 0.0 | -2.0 | 0.0 | -2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -8.0 | 0.0 | -6.0 | -1.0 | 2.0 | 0.0 | 2.0 | -2.0 | 0.1452625674720824 | Destabilising | -4.507 | Destabilising | -0.7684569479965898 | 0 | 0.0 | - | loop | 0.1 | 6.12 | VAL | -0.095 | -0.07825370675453049 | 5 | 5 | -0.332 | -0.038 | 6:5 | 147/150 | I:L:V:Q:F:A:E | 74 | 0.7789473684210526 | 85 | effect | pnca_p.val125asp | 0.0002156101768003 | -9.98760797391818 | 4.5966027178939e-05 | 0.930014323968984 | 113.719344729606 | -0.0878268160765965 | 127.948735098941 | 0.807902480033628 | -0.0926410587047397 | 0.0 | 1.0 | 0.0 | 0.0 | 11.7369754738005 | 0.000393645565148 | 0.984170607395186 | -2.67 | -0.6989528795811518 | Destabilising | ASP | 0 | pnca_complex.pdb | |
| 286 | V125F | V | 125 | F | A | PZA | 21.367 | -1.739 | Destabilising | -1.707 | Destabilising | -0.4493540051679586 | -0.432370820668693 | V125 | VA125 | 4.56 | -20.0 | -4.0 | 0.0 | -2.0 | -2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -11.0 | 0.0 | -6.0 | -10.0 | -2.0 | 0.0 | -6.0 | -2.0 | 0.16608512591146496 | Destabilising | -1.65 | Destabilising | -0.28132992327365725 | 0 | 0.0 | - | loop | 0.1 | 6.12 | VAL | -0.095 | -0.07825370675453049 | 5 | 5 | -0.332 | -0.038 | 6:5 | 147/150 | I:L:V:Q:F:A:E | 48 | 0.5052631578947369 | 71 | effect | pnca_p.val125phe | 0.0001437401178668 | -9.98752126245059 | 4.59700131334263e-05 | 0.942832958100734 | 139.277183325398 | -0.0717096729269461 | 144471.706314848 | 1.2119588062211 | 0.0834878586628579 | 0.0 | 1.0 | 0.0 | 0.0 | 25.8386585962163 | 1.0105682238915901e-25 | 0.999999999999746 | -1.72 | -0.4502617801047121 | Destabilising | PHE | 0 | pnca_complex.pdb | |
| 287 | V125A | V | 125 | A | A | PZA | 21.367 | -2.449 | Destabilising | -1.941 | Destabilising | -0.6328165374677002 | -0.4916413373860182 | V125 | VA125 | 2.08114 | 4.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -1.0 | 2.0 | 4.0 | 0.0 | 4.0 | 5.0 | 0.07579964889021627 | Destabilising | -2.189 | Destabilising | -0.373231031543052 | 0 | 0.0 | - | loop | 0.1 | 6.12 | VAL | -0.095 | -0.07825370675453049 | 5 | 5 | -0.332 | -0.038 | 6:5 | 147/150 | I:L:V:Q:F:A:E | 49 | 0.5157894736842106 | 71 | effect | -1.89 | -0.4947643979057591 | Destabilising | ALA | 0 | pnca_complex.pdb | ||||||||||||||||||
| 288 | D126E | D | 126 | E | A | PZA | 23.083 | -0.157 | Destabilising | 0.035 | Stabilising | -0.0405684754521963 | 0.0156950672645739 | D126 | DA126 | -0.5659569999999999 | -2.0 | 2.0 | 0.0 | 0.0 | 2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -1.0 | 0.0 | 0.0 | -1.0 | 0.0 | 0.0 | 0.0 | -2.0 | -0.10881277397523648 | Stabilising | -0.068 | Destabilising | -0.011594202898550725 | 66 | 0.3419689119170984 | - | loop | -0.9333333333333332 | 4.35 | ASP | 3.12 | 1.0 | 1 | 1 | 1.712 | 3.125 | 1:1 | 147/150 | D:T:M:S:A:G:L:N:V:K:R:H:E:Y:Q | -71 | -0.7634408602150538 | 87 | neutral | -0.55 | -0.143979057591623 | Destabilising | GLU | 0 | pnca_complex.pdb | ||||||||||||||||||
| 289 | E127D | E | 127 | D | A | PZA | 20.54 | -1.341 | Destabilising | -1.005 | Destabilising | -0.3465116279069767 | -0.2545592705167173 | E127 | EA127 | 2.77841 | 6.0 | -2.0 | 0.0 | 0.0 | -2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.0 | 0.0 | 0.0 | 2.0 | 0.0 | 0.0 | 0.0 | 0.0 | -3.0 | 0.0 | -2.0 | -3.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.10119574006220908 | Destabilising | -0.674 | Destabilising | -0.11491901108269395 | 55 | 0.2466367713004484 | E | strand | -0.9333333333333332 | 5.17 | GLU | 0.916 | 0.2935897435897436 | 2 | 2 | 0.59 | 1.183 | 3:1 | 147/150 | D:T:S:G:A:R:K:N:L:Q:H:E | -42 | -0.45161290322580644 | 72 | neutral | -1.29 | -0.3376963350785341 | Destabilising | ASP | 0 | pnca_complex.pdb | ||||||||||||||||||
| 290 | E127V | E | 127 | V | A | PZA | 20.54 | 0.4539999999999999 | Stabilising | -2.247 | Destabilising | 0.3860544217687074 | -0.5691489361702128 | E127 | EA127 | -0.8679600000000001 | 14.0 | 24.0 | 0.0 | 4.0 | 20.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.0 | 0.0 | 0.0 | 2.0 | 0.0 | 0.0 | 0.0 | 0.0 | -3.0 | 0.0 | -3.0 | 0.0 | -2.0 | 0.0 | -2.0 | -2.0 | -0.16687687456740755 | Stabilising | -0.221 | Destabilising | -0.03768115942028986 | 55 | 0.2466367713004484 | E | strand | -0.9333333333333332 | 5.17 | GLU | 0.916 | 0.2935897435897436 | 2 | 2 | 0.59 | 1.183 | 3:1 | 147/150 | D:T:S:G:A:R:K:N:L:Q:H:E | 12 | 0.12631578947368421 | 59 | effect | -0.33 | -0.0863874345549738 | Destabilising | VAL | 0 | pnca_complex.pdb | ||||||||||||||||||
| 291 | V128F | V | 128 | F | A | PZA | 16.575 | -1.849 | Destabilising | -2.082 | Destabilising | -0.4777777777777777 | -0.5273556231003039 | V128 | VA128 | 2.63855 | -34.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -11.0 | 0.0 | -3.0 | -10.0 | -4.0 | 0.0 | -2.0 | -8.0 | 0.09610173442405612 | Destabilising | -1.167 | Destabilising | -0.1989769820971867 | 0 | 0.0 | E | strand | -0.9333333333333332 | 8.31 | VAL | -0.394 | -0.3245469522240527 | 6 | 6 | -0.553 | -0.332 | 7:6 | 147/150 | V:L:I:A | 58 | 0.6105263157894737 | 75 | effect | pnca_p.val128phe | 7.18700589334483e-05 | 12.1451538387252 | 188179.926264397 | 0.919026337424191 | 119.468044436157 | 0.101660271548309 | 5.01153666069775e-06 | 9.70142977291842 | 0.986835744238421 | inf | 0.170978870202674 | 0.767057556984365 | 0.124324963210678 | inf | 0.763784339928386 | 0.382146811758261 | -1.73 | -0.4528795811518324 | Destabilising | PHE | 0 | pnca_complex.pdb | |
| 292 | V128G | V | 128 | G | A | PZA | 16.575 | -3.564 | Destabilising | -1.823 | Destabilising | -0.9209302325581394 | -0.4617527862208714 | V128 | VA128 | 4.66562 | 16.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 6.0 | 0.0 | 7.0 | 23.0 | 0.16993203621821254 | Destabilising | -4.952 | Destabilising | -0.8443307757885763 | 0 | 0.0 | E | strand | -0.9333333333333332 | 8.31 | VAL | -0.394 | -0.3245469522240527 | 6 | 6 | -0.553 | -0.332 | 7:6 | 147/150 | V:L:I:A | 75 | 0.7894736842105263 | 85 | effect | pnca_p.val128gly | 0.0010061808250682 | 3.37534823794128 | 29.2344625578696 | 9.91219225447489e-06 | 0.763812419492775 | 4.41908006704415 | 7.9656644717311 | 187.959563815878 | 29.234474017744 | 1.46589528448265 | 29.200882251631 | 3.94377277607243e-08 | 7.40408811526751 | 6.49943487243223 | 267.206211303594 | 41.8296883276733 | 9.95798685333635e-11 | -3.82 | -1.0 | Destabilising | GLY | 0 | pnca_complex.pdb |
| 293 | D129N | D | 129 | N | A | PZA | 14.781 | -0.735 | Destabilising | -3.245 | Destabilising | -0.189922480620155 | -0.8219351570415401 | D129 | DA129 | 1.83782 | -2.0 | 38.0 | 0.0 | 4.0 | 34.0 | 0.0 | 0.0 | 0.0 | 0.0 | -2.0 | 0.0 | -2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -1.0 | 0.0 | 0.0 | 0.0 | 2.0 | 0.0 | 0.06693740484706329 | Destabilising | -2.127 | Destabilising | -0.36265984654731453 | 0 | 0.0 | E | strand | 1.6333333333333335 | 7.77 | ASP | 0.074 | 0.023717948717948717 | 5 | 5 | -0.147 | 0.225 | 6:4 | 147/150 | I:V:L:E:Y:H:F:D:W:S:A:T | 72 | 0.7578947368421053 | 85 | effect | pnca_p.asp129asn | 7.18700589334483e-05 | -8.98740878149641 | 0.0001249735077034 | 0.940032862253634 | 119.468044435493 | -0.0752285585987741 | 4692673.51081231 | 2.42412778478352 | 0.384555509373631 | 0.0 | 1.0 | 0.0 | 0.0 | 188.544222231268 | 1.0341007080334399e-29 | 0.999999999999997 | -0.87 | -0.2277486910994764 | Destabilising | ASN | 0 | pnca_complex.pdb | |
| 294 | D129G | D | 129 | G | A | PZA | 14.781 | -0.65 | Destabilising | -3.948 | Destabilising | -0.1679586563307493 | -1.0 | D129 | DA129 | 4.68356 | 34.0 | 36.0 | 0.0 | 4.0 | 32.0 | 0.0 | 0.0 | 0.0 | 0.0 | 4.0 | 0.0 | 0.0 | 4.0 | 0.0 | 0.0 | 0.0 | 0.0 | 4.0 | 0.0 | 0.0 | 4.0 | 4.0 | 0.0 | 11.0 | 19.0 | 0.1705854500688379 | Destabilising | -2.685 | Destabilising | -0.4578005115089514 | 0 | 0.0 | E | strand | 1.6333333333333335 | 7.77 | ASP | 0.074 | 0.023717948717948717 | 5 | 5 | -0.147 | 0.225 | 6:4 | 147/150 | I:V:L:E:Y:H:F:D:W:S:A:T | 77 | 0.8105263157894737 | 85 | effect | pnca_p.asp129gly | 7.18700589334483e-05 | -8.98740878149641 | 0.0001249735077034 | 0.940032862253633 | 119.468044435492 | -0.0752285585987749 | 4692673.51081121 | 2.42412778478352 | 0.384555509373631 | 0.0 | 1.0 | 0.0 | 0.0 | 188.544222231268 | 1.0341007080334399e-29 | 0.999999999999997 | -0.43 | -0.112565445026178 | Destabilising | GLY | 0 | pnca_complex.pdb | |
| 295 | D129Y | D | 129 | Y | A | PZA | 14.781 | 0.187 | Stabilising | -2.832 | Destabilising | 0.1590136054421768 | -0.7173252279635258 | D129 | DA129 | 3.80937 | -40.0 | 34.0 | 0.0 | 4.0 | 30.0 | 0.0 | 0.0 | 0.0 | 0.0 | 4.0 | 0.0 | 0.0 | 2.0 | 0.0 | 0.0 | 0.0 | 0.0 | -8.0 | 0.0 | -3.0 | -5.0 | 8.0 | 0.0 | 4.0 | 2.0 | 0.13874554738889414 | Destabilising | 0.436 | Stabilising | 0.36824324324324326 | 0 | 0.0 | E | strand | 1.6333333333333335 | 7.77 | ASP | 0.074 | 0.023717948717948717 | 5 | 5 | -0.147 | 0.225 | 6:4 | 147/150 | I:V:L:E:Y:H:F:D:W:S:A:T | 42 | 0.4421052631578947 | 71 | effect | pnca_p.asp129tyr | 7.18700589334483e-05 | 12.1451538387262 | 188179.926264589 | 0.919026337424226 | 119.468044436217 | 0.101660271548266 | 5.0115366606409e-06 | 9.70142977291842 | 0.986835744238421 | inf | 0.170978870202674 | 0.767057556984365 | 0.124324963210678 | inf | 0.763784339928386 | 0.382146811758261 | 0.12 | 0.0674157303370786 | Stabilising | TYR | 0 | pnca_complex.pdb | |
| 296 | V130A | V | 130 | A | A | PZA | 10.402 | -2.827 | Destabilising | -1.3769999999999998 | Destabilising | -0.7304909560723514 | -0.3487841945288753 | V130 | VA130 | 3.70939 | 2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 3.0 | 0.0 | 3.0 | 0.0 | 4.0 | 0.0 | 4.0 | 3.0 | 0.1351040581589318 | Destabilising | -2.959 | Destabilising | -0.5045183290707588 | 0 | 0.0 | E | strand | 1.6333333333333335 | 11.27 | VAL | 0.064 | 0.020512820512820513 | 5 | 5 | -0.147 | 0.225 | 6:4 | 147/150 | M:F:D:C:I:L:V | 51 | 0.5368421052631579 | 75 | effect | pnca_p.val130ala | 7.18700589334483e-05 | -8.98740878149641 | 0.0001249735077034 | 0.940032862253633 | 119.468044435491 | -0.0752285585987751 | 4692673.51081327 | 2.42412778478352 | 0.384555509373631 | 0.0 | 1.0 | 0.0 | 0.0 | 188.544222231268 | 1.0341007080334399e-29 | 0.999999999999997 | -2.32 | -0.6073298429319371 | Destabilising | ALA | 0 | pnca_complex.pdb | |
| 297 | V130M | V | 130 | M | A | PZA | 10.402 | -1.539 | Destabilising | -2.265 | Destabilising | -0.3976744186046512 | -0.5737082066869301 | V130 | VA130 | -0.7073020000000001 | -58.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -2.0 | 0.0 | 3.0 | -5.0 | -4.0 | 0.0 | 2.0 | -6.0 | -0.1359882334845805 | Stabilising | -2.385 | Destabilising | -0.4066496163682864 | 0 | 0.0 | E | strand | 1.6333333333333335 | 11.27 | VAL | 0.064 | 0.020512820512820513 | 5 | 5 | -0.147 | 0.225 | 6:4 | 147/150 | M:F:D:C:I:L:V | 34 | 0.35789473684210527 | 66 | effect | pnca_p.val130met | 7.18700589334483e-05 | -8.98740878149642 | 0.0001249735077034 | 0.940032862253634 | 119.468044435493 | -0.0752285585987741 | 4692673.5108132 | 2.42412778478352 | 0.384555509373631 | 0.0 | 1.0 | 0.0 | 0.0 | 188.544222231268 | 1.0341007080334399e-29 | 0.999999999999997 | -1.31 | -0.3429319371727748 | Destabilising | MET | 0 | pnca_complex.pdb | |
| 298 | V130G | V | 130 | G | A | PZA | 10.402 | -3.429 | Destabilising | -1.126 | Destabilising | -0.8860465116279069 | -0.2852077001013171 | V130 | VA130 | 5.77612 | 20.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 3.0 | 0.0 | 3.0 | 0.0 | 8.0 | 0.0 | 9.0 | 23.0 | 0.21037886348239715 | Destabilising | -4.805 | Destabilising | -0.8192668371696504 | 0 | 0.0 | E | strand | 1.6333333333333335 | 11.27 | VAL | 0.064 | 0.020512820512820513 | 5 | 5 | -0.147 | 0.225 | 6:4 | 147/150 | M:F:D:C:I:L:V | 73 | 0.7684210526315789 | 85 | effect | pnca_p.val130gly | 0.0001437401178668 | 13.1456002256202 | 511754.463552424 | 0.924803768446987 | 139.277183326542 | 0.0943844491369394 | 0.0001628371344458 | 19.411022297013 | 1.28804840845689 | inf | 0.0292235860951597 | 1.53426649183163 | 0.91081598550184 | inf | 4.73122070382274 | 0.0296198560706035 | -3.46 | -0.9057591623036648 | Destabilising | GLY | 0 | pnca_complex.pdb | |
| 299 | V130E | V | 130 | E | A | PZA | 10.402 | -3.207 | Destabilising | -0.292 | Destabilising | -0.8286821705426356 | -0.0739614994934143 | V130 | VA130 | 5.05456 | -46.0 | -56.0 | 0.0 | -4.0 | -52.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -5.0 | 0.0 | 0.0 | -5.0 | -2.0 | 0.0 | 2.0 | -4.0 | 0.18409807763751193 | Destabilising | -5.67 | Destabilising | -0.9667519181585678 | 0 | 0.0 | E | strand | 1.6333333333333335 | 11.27 | VAL | 0.064 | 0.020512820512820513 | 5 | 5 | -0.147 | 0.225 | 6:4 | 147/150 | M:F:D:C:I:L:V | 75 | 0.7894736842105263 | 85 | effect | pnca_p.val130glu | 0.0001437401178668 | 13.1456002256204 | 511754.46355254 | 0.924803768446994 | 139.277183326557 | 0.0943844491369309 | 0.0001628371344454 | 19.411022297013 | 1.28804840845689 | inf | 0.0292235860951597 | 1.53426649183163 | 0.91081598550184 | inf | 4.73122070382274 | 0.0296198560706035 | -1.74 | -0.4554973821989529 | Destabilising | GLU | 0 | pnca_complex.pdb | |
| 300 | V131G | V | 131 | G | A | PZA | 9.063 | -3.182 | Destabilising | -1.774 | Destabilising | -0.8222222222222222 | -0.4493414387031408 | V131 | VA131 | 5.35345 | 6.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.0 | 0.0 | 3.0 | 19.0 | 0.1949843020418272 | Destabilising | -3.989 | Destabilising | -0.6801364023870418 | 1 | 0.0057471264367816 | E | strand | 2.6666666666666665 | 10.36 | VAL | 0.204 | 0.06538461538461537 | 4 | 4 | -0.038 | 0.389 | 5:4 | 147/150 | D:M:S:A:G:T:C:V:L | 54 | 0.5684210526315789 | 75 | effect | pnca_p.val131gly | 0.0001437401178668 | 13.145600225622 | 511754.463553338 | 0.924803768447044 | 139.277183326667 | 0.0943844491368676 | 0.0001628371344429 | 19.411022297013 | 1.28804840845689 | inf | 0.0292235860951597 | 1.53426649183163 | 0.91081598550184 | inf | 4.73122070382274 | 0.0296198560706035 | -2.53 | -0.662303664921466 | Destabilising | GLY | 0 | pnca_complex.pdb | |
| 301 | V131F | V | 131 | F | A | PZA | 9.063 | -1.59 | Destabilising | -2.323 | Destabilising | -0.4108527131782946 | -0.5883991894630193 | V131 | VA131 | 1.54666 | -44.0 | -4.0 | 0.0 | 0.0 | -4.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -15.0 | 0.0 | -7.0 | -8.0 | -6.0 | 0.0 | -8.0 | -8.0 | 0.0563327238689093 | Destabilising | -1.786 | Destabilising | -0.3045183290707587 | 1 | 0.0057471264367816 | E | strand | 2.6666666666666665 | 10.36 | VAL | 0.204 | 0.06538461538461537 | 4 | 4 | -0.038 | 0.389 | 5:4 | 147/150 | D:M:S:A:G:T:C:V:L | 72 | 0.7578947368421053 | 85 | effect | pnca_p.val131phe | 0.0001437401178668 | 13.1456002256219 | 511754.463553315 | 0.924803768447041 | 139.277183326661 | 0.0943844491368713 | 0.000162837134443 | 19.411022297013 | 1.28804840845689 | inf | 0.0292235860951597 | 1.53426649183163 | 0.91081598550184 | inf | 4.73122070382274 | 0.0296198560706035 | -1.52 | -0.3979057591623037 | Destabilising | PHE | 0 | pnca_complex.pdb | |
| 302 | G132D | G | 132 | D | A | PZA | 6.912000000000001 | -2.518 | Destabilising | -0.8220000000000001 | Destabilising | -0.6506459948320414 | -0.2082066869300912 | G132 | GA132 | 18.6426 | -22.0 | -42.0 | 0.0 | -2.0 | -40.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -11.0 | 0.0 | -9.0 | -6.0 | -4.0 | 0.0 | -9.0 | -23.0 | 0.6790040719993591 | Destabilising | -3.507 | Destabilising | -0.5979539641943734 | 0 | 0.0 | E | strand | 2.766666666666666 | 8.75 | GLY | -1.191 | -0.9810543657331138 | 9 | 9 | -1.229 | -1.178 | 9:9 | 147/150 | G | 92 | 0.968421052631579 | 95 | effect | pnca_p.gly132asp | 0.0004312203536006 | 14.1472939191334 | 1393450.94022859 | 0.915018435775164 | 132.576060676564 | 0.106710773022948 | 4.17896182038204 | 58.3312262958281 | 1.7659011066874 | inf | 2.48532104922106e-05 | 4.60461750194108 | 5.71767556863798 | inf | 23.547488635408 | 1.21868387173808e-06 | -1.46 | -0.3821989528795811 | Destabilising | ASP | 0 | pnca_complex.pdb | |
| 303 | G132A | G | 132 | A | A | PZA | 6.912000000000001 | -0.8290000000000001 | Destabilising | -1.92 | Destabilising | -0.2142118863049095 | -0.486322188449848 | G132 | GA132 | 5.5504 | -4.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -6.0 | 0.0 | -6.0 | -2.0 | 0.0 | 0.0 | -7.0 | -18.0 | 0.20215764974977965 | Destabilising | -2.927 | Destabilising | -0.4990622335890878 | 0 | 0.0 | E | strand | 2.766666666666666 | 8.75 | GLY | -1.191 | -0.9810543657331138 | 9 | 9 | -1.229 | -1.178 | 9:9 | 147/150 | G | 80 | 0.8421052631578947 | 91 | effect | pnca_p.gly132ala | 0.0005749604714675 | 2.6796663501904 | 14.5802277940117 | 0.0010245352377104 | 0.816050632122417 | 3.28370108999367 | 3.35697961122016 | 99.5538692591549 | 14.5802781289507 | 1.16376580853041 | 14.5801759034061 | 0.0005075351447614 | 3.29453387923245 | 2.60435121163486 | 147.676327006136 | 15.0663448164144 | 0.0001037975122989 | -0.28 | -0.0732984293193717 | Destabilising | ALA | 0 | pnca_complex.pdb |
| 304 | G132S | G | 132 | S | A | PZA | 6.912000000000001 | -2.061 | Destabilising | -0.312 | Destabilising | -0.5325581395348837 | -0.0790273556231003 | G132 | GA132 | 10.5344 | -4.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -8.0 | 0.0 | -8.0 | -4.0 | 0.0 | 0.0 | -7.0 | -19.0 | 0.38368577859687203 | Destabilising | -3.165 | Destabilising | -0.5396419437340153 | 0 | 0.0 | E | strand | 2.766666666666666 | 8.75 | GLY | -1.191 | -0.9810543657331138 | 9 | 9 | -1.229 | -1.178 | 9:9 | 147/150 | G | 85 | 0.8947368421052632 | 91 | effect | pnca_p.gly132ser | 0.0005749604714675 | 14.1481370895088 | 1394626.35224766 | 0.901927875940771 | 114.814237034556 | 0.123226330243789 | 82.9586021393604 | 77.8405735976381 | 1.89120602753485 | inf | 7.2326389241213e-07 | 6.1407032156959 | 8.29603358299821 | inf | 33.1802749271012 | 8.399830460993881e-09 | -1.17 | -0.306282722513089 | Destabilising | SER | 0 | pnca_complex.pdb | |
| 305 | I133T | I | 133 | T | A | PZA | 3.05 | -2.7880000000000003 | Destabilising | 0.703 | Stabilising | -0.7204134366925065 | 0.3152466367713004 | I133 | IA133 | 1.57844 | 34.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -2.0 | 0.0 | -2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 4.0 | 0.0 | 4.0 | 0.0 | 0.05749022064554666 | Destabilising | -1.862 | Destabilising | -0.3174765558397272 | 3 | 0.015228426395939 | E | strand | 1.9666666666666668 | 7.9 | ILE | -0.739 | -0.6087314662273476 | 8 | 8 | -0.872 | -0.674 | 8:7 | 147/150 | V:L:I:M:F | 68 | 0.7157894736842105 | 80 | effect | pnca_p.ile133thr | 0.0031622825930717 | 1.86205820059201 | 6.43697172567821 | 1.0518317723875602e-09 | 0.305188422646507 | 6.10133957390906 | 3.55222271070208 | 11.8555583489231 | 6.43697178374994 | 0.808681605417837 | 6.43569721125883 | 2.90039620895666e-09 | 8.53754267120101 | 3.39739251160169 | 12.3875045168727 | 46.3588997045238 | 9.845927533322829e-12 | -2.56 | -0.6701570680628273 | Destabilising | THR | 0 | pnca_complex.pdb |
| 306 | I133S | I | 133 | S | A | PZA | 3.05 | -3.219 | Destabilising | 0.578 | Stabilising | -0.8317829457364341 | 0.2591928251121076 | I133 | IA133 | 3.30196 | 34.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -2.0 | 0.0 | -2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 6.0 | 0.0 | 8.0 | 0.0 | 0.12026457069180281 | Destabilising | -2.461 | Destabilising | -0.41960784313725485 | 3 | 0.015228426395939 | E | strand | 1.9666666666666668 | 7.9 | ILE | -0.739 | -0.6087314662273476 | 8 | 8 | -0.872 | -0.674 | 8:7 | 147/150 | V:L:I:M:F | 70 | 0.7368421052631579 | 85 | effect | pnca_p.ile133ser | 7.18700589334483e-05 | 12.1451538387262 | 188179.926264589 | 0.919026337424226 | 119.468044436218 | 0.101660271548266 | 5.01153666064073e-06 | 9.70142977291842 | 0.986835744238421 | inf | 0.170978870202674 | 0.767057556984365 | 0.124324963210678 | inf | 0.763784339928386 | 0.382146811758261 | -3.47 | -0.9083769633507854 | Destabilising | SER | 0 | pnca_complex.pdb | |
| 307 | A134V | A | 134 | V | A | PZA | 3.047 | -0.414 | Destabilising | 0.118 | Stabilising | -0.1069767441860465 | 0.052914798206278 | A134 | AA134 | -1.46184 | -6.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -2.0 | 0.0 | -2.0 | -6.0 | -2.0 | 0.0 | -2.0 | -3.0 | -0.2810582173344613 | Stabilising | -1.64 | Destabilising | -0.27962489343563507 | 10 | 0.0775193798449612 | - | loop | 1.8666666666666665 | 6.77 | ALA | -1.111 | -0.9151565074135091 | 9 | 9 | -1.178 | -1.094 | 9:9 | 147/150 | V:T:S:A | 74 | 0.7789473684210526 | 85 | effect | pnca_p.ala134val | 0.0003593502946672 | 2.96659528728018 | 19.4256680571767 | 0.0079500503166053 | 1.11770528264822 | 2.65418382943607 | 2.87215213651462 | 380.097158975588 | 19.4256842105263 | 1.28837632444196 | 19.4169790983636 | 0.0036816889015929 | 2.43395291165754 | 1.92061868691892 | 951.403114304703 | 9.87561363723508 | 0.0016748373055023 | -0.88 | -0.2303664921465968 | Destabilising | VAL | 0 | pnca_complex.pdb |
| 308 | A134T | A | 134 | T | A | PZA | 3.047 | -1.925 | Destabilising | 0.875 | Stabilising | -0.4974160206718346 | 0.3923766816143498 | A134 | AA134 | -0.943073 | -6.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -2.0 | 0.0 | -2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -2.0 | 0.0 | 0.0 | -4.0 | -2.0 | 0.0 | -2.0 | -3.0 | -0.1813183496116281 | Stabilising | -1.723 | Destabilising | -0.2937766410912191 | 10 | 0.0775193798449612 | - | loop | 1.8666666666666665 | 6.77 | ALA | -1.111 | -0.9151565074135091 | 9 | 9 | -1.178 | -1.094 | 9:9 | 147/150 | V:T:S:A | 61 | 0.6421052631578947 | 80 | effect | -1.44 | -0.3769633507853403 | Destabilising | THR | 0 | pnca_complex.pdb | ||||||||||||||||||
| 309 | A134G | A | 134 | G | A | PZA | 3.047 | -1.618 | Destabilising | -0.3779999999999999 | Destabilising | -0.4180878552971576 | -0.0957446808510638 | A134 | AA134 | -1.28536 | 2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 1.0 | 0.0 | 0.0 | 0.0 | 3.0 | 14.0 | -0.24712758594170578 | Stabilising | -2.508 | Destabilising | -0.42762148337595907 | 10 | 0.0775193798449612 | - | loop | 1.8666666666666665 | 6.77 | ALA | -1.111 | -0.9151565074135091 | 9 | 9 | -1.178 | -1.094 | 9:9 | 147/150 | V:T:S:A | 79 | 0.8315789473684211 | 85 | effect | -1.88 | -0.4921465968586387 | Destabilising | GLY | 0 | pnca_complex.pdb | ||||||||||||||||||
| 310 | A134P | A | 134 | P | A | PZA | 3.047 | -1.426 | Destabilising | 0.077 | Stabilising | -0.3684754521963824 | 0.0345291479820627 | A134 | AA134 | -5.2012 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 1.0 | 1.0 | -1.0 | -2.0 | -2.0 | 0.0 | 0.0 | -9.0 | -1.0 | Stabilising | -2.503 | Destabilising | -0.426768968456948 | 10 | 0.0775193798449612 | - | loop | 1.8666666666666665 | 6.77 | ALA | -1.111 | -0.9151565074135091 | 9 | 9 | -1.178 | -1.094 | 9:9 | 147/150 | V:T:S:A | 88 | 0.9263157894736842 | 91 | effect | pnca_p.ala134pro | 7.18700589334483e-05 | 12.1451538387265 | 188179.92626465 | 0.919026337424237 | 119.468044436237 | 0.101660271548252 | 5.01153666062244e-06 | 9.70142977291842 | 0.986835744238421 | inf | 0.170978870202674 | 0.767057556984365 | 0.124324963210678 | inf | 0.763784339928386 | 0.382146811758261 | -0.19 | -0.0497382198952879 | Destabilising | PRO | 0 | pnca_complex.pdb | |
| 311 | A134D | A | 134 | D | A | PZA | 3.047 | -2.98 | Destabilising | 0.5820000000000001 | Stabilising | -0.7700258397932817 | 0.2609865470852018 | A134 | AA134 | 1.03055 | -24.0 | -34.0 | 0.0 | 0.0 | -34.0 | 0.0 | 0.0 | 0.0 | 0.0 | -2.0 | 0.0 | -2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -2.0 | -4.0 | 0.0 | -2.0 | -3.0 | 0.03753487423422374 | Destabilising | -3.856 | Destabilising | -0.6574595055413469 | 10 | 0.0775193798449612 | - | loop | 1.8666666666666665 | 6.77 | ALA | -1.111 | -0.9151565074135091 | 9 | 9 | -1.178 | -1.094 | 9:9 | 147/150 | V:T:S:A | 85 | 0.8947368421052632 | 91 | effect | pnca_p.ala134asp | 7.18700589334483e-05 | -8.98740878149643 | 0.0001249735077034 | 0.940032862253634 | 119.468044435494 | -0.0752285585987736 | 4692673.510814 | 2.42412778478352 | 0.384555509373631 | 0.0 | 1.0 | 0.0 | 0.0 | 188.544222231268 | 1.0341007080334399e-29 | 0.999999999999997 | -1.13 | -0.2958115183246073 | Destabilising | ASP | 0 | pnca_complex.pdb | |
| 312 | T135I | T | 135 | I | A | PZA | 6.021 | 0.442 | Stabilising | -1.039 | Destabilising | 0.3758503401360544 | -0.2631712259371834 | T135 | TA135 | -0.624872 | -10.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 4.0 | 0.0 | -2.0 | 4.0 | 0.0 | 0.0 | 0.0 | 0.0 | -3.0 | 0.0 | -1.0 | 0.0 | 2.0 | 0.0 | 2.0 | -4.0 | -0.12013996769976158 | Stabilising | -0.279 | Destabilising | -0.04757033248081842 | 3 | 0.0174418604651162 | T | loop | -0.7999999999999999 | 5.97 | THR | -0.612 | -0.5041186161449753 | 7 | 7 | -0.728 | -0.553 | 8:7 | 147/150 | G:S:M:A:T:L:R:E:Y:F:Q | 86 | 0.9052631578947369 | 91 | effect | pnca_p.thr135ile | 7.18700589334483e-05 | -8.9874087814964 | 0.0001249735077034 | 0.940032862253633 | 119.46804443549 | -0.0752285585987755 | 4692673.5108109 | 2.42412778478352 | 0.384555509373631 | 0.0 | 1.0 | 0.0 | 0.0 | 188.544222231268 | 1.0341007080334399e-29 | 0.999999999999997 | 0.66 | 0.3707865168539326 | Stabilising | ILE | 0 | pnca_complex.pdb | |
| 313 | T135P | T | 135 | P | A | PZA | 6.021 | -0.141 | Destabilising | -1.103 | Destabilising | -0.0364341085271317 | -0.2793819655521783 | T135 | TA135 | 4.22994 | 4.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 6.0 | 2.0 | -2.0 | 4.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.0 | 0.0 | 0.0 | 4.0 | 0.0 | 4.0 | -2.0 | 0.15406362225832065 | Destabilising | -2.513 | Destabilising | -0.4284739982949701 | 3 | 0.0174418604651162 | T | loop | -0.7999999999999999 | 5.97 | THR | -0.612 | -0.5041186161449753 | 7 | 7 | -0.728 | -0.553 | 8:7 | 147/150 | G:S:M:A:T:L:R:E:Y:F:Q | 93 | 0.9789473684210527 | 95 | effect | pnca_p.thr135pro | 0.0019404915912031 | 4.84770422501703 | 127.447463030391 | 1.95563371409724e-06 | 1.01886282652061 | 4.75795573146171 | 27.0895053611136 | 2275.86435679243 | 127.447513812155 | 2.10533136786968 | 127.547977311481 | 2.29679039420522e-19 | 18.638878636844 | 20.9103539725502 | 5063.91643152716 | 114.177692609973 | 1.1913921230384099e-26 | 0.5 | 0.2808988764044944 | Stabilising | PRO | 0 | pnca_complex.pdb |
| 314 | T135A | T | 135 | A | A | PZA | 6.021 | -0.347 | Destabilising | -1.324 | Destabilising | -0.0896640826873385 | -0.3353596757852077 | T135 | TA135 | 0.939971 | 4.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 4.0 | 0.0 | -2.0 | 4.0 | 0.0 | 0.0 | 0.0 | 0.0 | 4.0 | 0.0 | 4.0 | 2.0 | 6.0 | 0.0 | 6.0 | 3.0 | 0.03423578988774685 | Destabilising | -1.151 | Destabilising | -0.19624893435635124 | 3 | 0.0174418604651162 | T | loop | -0.7999999999999999 | 5.97 | THR | -0.612 | -0.5041186161449753 | 7 | 7 | -0.728 | -0.553 | 8:7 | 147/150 | G:S:M:A:T:L:R:E:Y:F:Q | 72 | 0.7578947368421053 | 85 | effect | -0.32 | -0.0837696335078534 | Destabilising | ALA | 0 | pnca_complex.pdb | ||||||||||||||||||
| 315 | T135S | T | 135 | S | A | PZA | 6.021 | -1.605 | Destabilising | -0.7090000000000001 | Destabilising | -0.4147286821705426 | -0.1795845997973657 | T135 | TA135 | 0.77889 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 3.0 | 0.0 | 1.0 | 2.0 | 2.0 | 0.0 | 2.0 | 2.0 | 0.028368869237101087 | Destabilising | -1.567 | Destabilising | -0.2671781756180733 | 3 | 0.0174418604651162 | T | loop | -0.7999999999999999 | 5.97 | THR | -0.612 | -0.5041186161449753 | 7 | 7 | -0.728 | -0.553 | 8:7 | 147/150 | G:S:M:A:T:L:R:E:Y:F:Q | 65 | 0.6842105263157895 | 80 | effect | pnca_p.thr135ser | 7.18700589334483e-05 | -8.98740878149641 | 0.0001249735077034 | 0.940032862253632 | 119.46804443549 | -0.075228558598776 | 4692673.51081184 | 2.42412778478352 | 0.384555509373631 | 0.0 | 1.0 | 0.0 | 0.0 | 188.544222231268 | 1.0341007080334399e-29 | 0.999999999999997 | -0.71 | -0.1858638743455497 | Destabilising | SER | 0 | pnca_complex.pdb | |
| 316 | D136Y | D | 136 | Y | A | PZA | 6.178999999999999 | -0.96 | Destabilising | -1.662 | Destabilising | -0.2480620155038759 | -0.4209726443768997 | D136 | DA136 | 6.12929 | -32.0 | 25.0 | 0.0 | 0.0 | 25.0 | 0.0 | 0.0 | 0.0 | 0.0 | 6.0 | 0.0 | 2.0 | 4.0 | 0.0 | 0.0 | 0.0 | 0.0 | -6.0 | 0.0 | -4.0 | -4.0 | -2.0 | 0.0 | 2.0 | -2.0 | 0.22324208363988665 | Destabilising | -1.07 | Destabilising | -0.1824381926683717 | 6 | 0.0310880829015544 | T | loop | -2.466666666666667 | 5.37 | ASP | -1.076 | -0.8863261943986821 | 9 | 9 | -1.152 | -1.028 | 9:9 | 147/150 | S:E:D | 86 | 0.9052631578947369 | 91 | effect | pnca_p.asp136tyr | 0.0002156101768003 | 13.1460210125005 | 511969.848429002 | 0.907969111549614 | 113.719344731947 | 0.115600569485232 | 0.183926936277317 | 29.1287878787879 | 1.4643224129316 | inf | 0.0049931328456149 | 2.3016268790981 | 2.00455510251839 | inf | 9.2872640727157 | 0.0023075254069185 | -0.23 | -0.0602094240837696 | Destabilising | TYR | 0 | pnca_complex.pdb | |
| 317 | D136A | D | 136 | A | A | PZA | 6.178999999999999 | 0.66 | Stabilising | -2.506 | Destabilising | 0.5612244897959184 | -0.6347517730496454 | D136 | DA136 | 1.50112 | 4.0 | 29.0 | 0.0 | 0.0 | 29.0 | 0.0 | 0.0 | 0.0 | 0.0 | 8.0 | 0.0 | 2.0 | 2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 4.0 | 0.0 | 0.0 | 4.0 | 6.0 | 0.0 | 10.0 | -3.0 | 0.05467405794039875 | Destabilising | -0.993 | Destabilising | -0.169309462915601 | 6 | 0.0310880829015544 | T | loop | -2.466666666666667 | 5.37 | ASP | -1.076 | -0.8863261943986821 | 9 | 9 | -1.152 | -1.028 | 9:9 | 147/150 | S:E:D | 73 | 0.7684210526315789 | 85 | effect | pnca_p.asp136ala | 7.18700589334483e-05 | 12.1451538387252 | 188179.926264403 | 0.919026337424193 | 119.468044436159 | 0.101660271548308 | 5.01153666069587e-06 | 9.70142977291842 | 0.986835744238421 | inf | 0.170978870202674 | 0.767057556984365 | 0.124324963210678 | inf | 0.763784339928386 | 0.382146811758261 | 1.78 | 1.0 | Stabilising | ALA | 0 | pnca_complex.pdb | |
| 318 | D136N | D | 136 | N | A | PZA | 6.178999999999999 | 0.216 | Stabilising | -1.58 | Destabilising | 0.1836734693877551 | -0.4002026342451875 | D136 | DA136 | 0.961088 | 0.0 | 29.0 | 0.0 | 0.0 | 29.0 | 0.0 | 0.0 | 0.0 | 0.0 | 4.0 | 0.0 | 0.0 | 2.0 | 0.0 | 0.0 | 0.0 | 0.0 | -5.0 | 0.0 | 3.0 | -9.0 | 4.0 | 0.0 | 2.0 | -4.0 | 0.03500491699385922 | Destabilising | -1.377 | Destabilising | -0.23478260869565218 | 6 | 0.0310880829015544 | T | loop | -2.466666666666667 | 5.37 | ASP | -1.076 | -0.8863261943986821 | 9 | 9 | -1.152 | -1.028 | 9:9 | 147/150 | S:E:D | 79 | 0.8315789473684211 | 85 | effect | pnca_p.asp136asn | 0.0005030904125341 | 1.29193858531542 | 3.63983585304829 | 0.0908665432562708 | 0.764078977125449 | 1.69084430273928 | 0.716519099632433 | 16.5222710930887 | 3.63983585858586 | 0.561081799221107 | 3.63936365398778 | 0.101883776579733 | 0.99189496518722 | 0.532738756693438 | 21.52594647947 | 1.71237896478786 | 0.190677002690395 | 0.48 | 0.2696629213483146 | Stabilising | ASN | 0 | pnca_complex.pdb |
| 319 | D136G | D | 136 | G | A | PZA | 6.178999999999999 | 0.314 | Stabilising | -2.5780000000000003 | Destabilising | 0.2670068027210884 | -0.6529888551165147 | D136 | DA136 | 2.04991 | 6.0 | 29.0 | 0.0 | 0.0 | 29.0 | 0.0 | 0.0 | 0.0 | 0.0 | 8.0 | 0.0 | 2.0 | 2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 5.0 | 0.0 | 5.0 | 2.0 | 8.0 | 0.0 | 13.0 | 15.0 | 0.07466218431078316 | Destabilising | -1.455 | Destabilising | -0.24808184143222506 | 6 | 0.0310880829015544 | T | loop | -2.466666666666667 | 5.37 | ASP | -1.076 | -0.8863261943986821 | 9 | 9 | -1.152 | -1.028 | 9:9 | 147/150 | S:E:D | 79 | 0.8315789473684211 | 85 | effect | pnca_p.asp136gly | 0.0008624407072013 | 1.24373033542254 | 3.46852813512699 | 0.0337889223820885 | 0.585951699076682 | 2.12258166907334 | 1.02578380758221 | 10.8758695145359 | 3.46852810205801 | 0.540145217509122 | 3.46809703626328 | 0.0400825565026472 | 1.39704458655237 | 0.867177455332643 | 12.7072994899286 | 3.5269411605584 | 0.0603790832350862 | 0.52 | 0.2921348314606741 | Stabilising | GLY | 0 | pnca_complex.pdb |
| 320 | H137N | H | 137 | N | A | PZA | 3.419 | 0.1889999999999999 | Stabilising | -0.124 | Destabilising | 0.1607142857142857 | -0.0314083080040526 | H137 | HA137 | 0.40144 | 14.0 | 3.0 | 0.0 | 0.0 | 3.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -1.0 | 0.0 | 1.0 | -1.0 | 4.0 | 0.0 | 2.0 | 2.0 | 0.014621318628486514 | Destabilising | -0.475 | Destabilising | -0.08098891730605284 | 84 | 0.375 | T | loop | -1.4 | 4.6 | HIS | -0.415 | -0.3418451400329489 | 7 | 7 | -0.615 | -0.332 | 7:6 | 147/150 | Q:H:F:E:Y:I:V:W | 65 | 0.6842105263157895 | 80 | effect | pnca_p.his137asn | 7.18700589334483e-05 | -8.98740878149642 | 0.0001249735077034 | 0.940032862253634 | 119.468044435493 | -0.075228558598774 | 4692673.51081254 | 2.42412778478352 | 0.384555509373631 | 0.0 | 1.0 | 0.0 | 0.0 | 188.544222231268 | 1.0341007080334399e-29 | 0.999999999999997 | 0.6 | 0.3370786516853932 | Stabilising | ASN | 0 | pnca_complex.pdb | |
| 321 | H137R | H | 137 | R | A | PZA | 3.419 | -0.272 | Destabilising | 0.466 | Stabilising | -0.0702842377260982 | 0.2089686098654708 | H137 | HA137 | 0.4886649999999999 | -52.0 | -2.0 | 0.0 | 0.0 | -2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 1.0 | 0.0 | 4.0 | -1.0 | -2.0 | 0.0 | -2.0 | -4.0 | 0.017798242994194302 | Destabilising | -0.317 | Destabilising | -0.054049445865302644 | 84 | 0.375 | T | loop | -1.4 | 4.6 | HIS | -0.415 | -0.3418451400329489 | 7 | 7 | -0.615 | -0.332 | 7:6 | 147/150 | Q:H:F:E:Y:I:V:W | 76 | 0.8 | 85 | effect | pnca_p.his137arg | 0.0002874802357337 | 1.57937329521209 | 4.85191414039981 | 0.114342297004304 | 1.0002536454007 | 1.57897279602454 | 0.581889091312819 | 40.4562911075324 | 4.85191417753471 | 0.685913110299906 | 4.85118443551178 | 0.137954936368295 | 0.860262754777729 | 0.351471331417763 | 67.0421060419706 | 1.17497090855698 | 0.278382201819561 | 0.21 | 0.1179775280898876 | Stabilising | ARG | 0 | pnca_complex.pdb |
| 322 | H137Y | H | 137 | Y | A | PZA | 3.419 | 0.8590000000000001 | Stabilising | -0.005 | Destabilising | 0.7304421768707484 | -0.0012664640324214 | H137 | HA137 | 0.344473 | -42.0 | 3.0 | 0.0 | 0.0 | 3.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.0 | 0.0 | 2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -1.0 | 0.0 | 1.0 | -4.0 | -2.0 | 0.0 | -2.0 | 0.0 | 0.012546456486425453 | Destabilising | -0.394 | Destabilising | -0.06717817561807332 | 84 | 0.375 | T | loop | -1.4 | 4.6 | HIS | -0.415 | -0.3418451400329489 | 7 | 7 | -0.615 | -0.332 | 7:6 | 147/150 | Q:H:F:E:Y:I:V:W | -7 | -0.07526881720430108 | 53 | neutral | pnca_p.his137tyr | 7.18700589334483e-05 | -8.98740878149642 | 0.0001249735077034 | 0.940032862253633 | 119.468044435491 | -0.0752285585987755 | 4692673.51081285 | 2.42412778478352 | 0.384555509373631 | 0.0 | 1.0 | 0.0 | 0.0 | 188.544222231268 | 1.0341007080334399e-29 | 0.999999999999997 | 1.72 | 0.9662921348314606 | Stabilising | TYR | 0 | pnca_complex.pdb | |
| 323 | H137P | H | 137 | P | A | PZA | 3.419 | 0.366 | Stabilising | -0.765 | Destabilising | 0.3112244897959184 | -0.1937689969604863 | H137 | HA137 | 2.19045 | 34.0 | 3.0 | 0.0 | 0.0 | 3.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.0 | 0.0 | 2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 4.0 | -2.0 | -4.0 | 2.0 | 0.0 | -4.0 | 0.0 | 0.07978095702911588 | Destabilising | -0.882 | Destabilising | -0.15038363171355498 | 84 | 0.375 | T | loop | -1.4 | 4.6 | HIS | -0.415 | -0.3418451400329489 | 7 | 7 | -0.615 | -0.332 | 7:6 | 147/150 | Q:H:F:E:Y:I:V:W | 86 | 0.9052631578947369 | 91 | effect | 1.03 | 0.5786516853932584 | Stabilising | PRO | 0 | pnca_complex.pdb | ||||||||||||||||||
| 324 | C138R | C | 138 | R | A | PZA | 3.282 | 0.099 | Stabilising | 0.35 | Stabilising | 0.0841836734693877 | 0.1569506726457399 | C138 | CA138 | -2.11829 | -86.0 | -32.0 | 0.0 | 0.0 | -32.0 | 0.0 | 0.0 | 0.0 | 0.0 | -2.0 | 0.0 | -2.0 | -2.0 | 0.0 | 0.0 | 0.0 | 0.0 | -5.0 | 0.0 | -1.0 | -6.0 | -14.0 | 0.0 | -6.0 | -12.0 | -0.40726947627470583 | Stabilising | -2.383 | Destabilising | -0.406308610400682 | 12 | 0.0718562874251497 | H | helix | 1.1666666666666667 | 6.7 | CYS | -1.148 | -0.9456342668863261 | 9 | 9 | -1.221 | -1.124 | 9:9 | 147/150 | C:S | 91 | 0.9578947368421052 | 95 | effect | pnca_p.cys138arg | 0.0008624407072013 | 15.1498290544778 | 3797407.11818115 | 0.921917088417709 | 154.559892765108 | 0.0980191483278375 | 60.4370486597206 | 116.958174904943 | 2.06803058263964 | inf | 6.09960824712391e-10 | 9.21469805705084 | 13.5248372165465 | inf | 52.5277145499225 | 4.2421933164431297e-13 | 0.53 | 0.297752808988764 | Stabilising | ARG | 0 | pnca_complex.pdb | |
| 325 | C138Y | C | 138 | Y | A | PZA | 3.282 | -0.518 | Destabilising | 0.914 | Stabilising | -0.1338501291989664 | 0.4098654708520179 | C138 | CA138 | -0.565013 | -72.0 | -40.0 | 0.0 | 0.0 | -40.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 1.0 | 0.0 | 0.0 | 1.0 | -12.0 | 0.0 | -2.0 | -14.0 | -0.10863127739752365 | Stabilising | -1.271 | Destabilising | -0.2167092924126172 | 12 | 0.0718562874251497 | H | helix | 1.1666666666666667 | 6.7 | CYS | -1.148 | -0.9456342668863261 | 9 | 9 | -1.221 | -1.124 | 9:9 | 147/150 | C:S | 90 | 0.9473684210526315 | 95 | effect | -0.44 | -0.1151832460732984 | Destabilising | TYR | 0 | pnca_complex.pdb | ||||||||||||||||||
| 326 | C138G | C | 138 | G | A | PZA | 3.282 | -0.015 | Destabilising | -0.012 | Destabilising | -0.003875968992248 | -0.0030395136778115 | C138 | CA138 | 1.12063 | 16.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 3.0 | 0.0 | 3.0 | 0.0 | 6.0 | 0.0 | 9.0 | 19.0 | 0.040815783914509865 | Destabilising | -2.578 | Destabilising | -0.4395566922421142 | 12 | 0.0718562874251497 | H | helix | 1.1666666666666667 | 6.7 | CYS | -1.148 | -0.9456342668863261 | 9 | 9 | -1.221 | -1.124 | 9:9 | 147/150 | C:S | 90 | 0.9473684210526315 | 95 | effect | 1.06 | 0.5955056179775281 | Stabilising | GLY | 0 | pnca_complex.pdb | ||||||||||||||||||
| 327 | C138S | C | 138 | S | A | PZA | 3.282 | -0.002 | Destabilising | 0.8140000000000001 | Stabilising | -0.000516795865633 | 0.3650224215246637 | C138 | CA138 | -0.229289 | 4.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 3.0 | 0.0 | 3.0 | 0.0 | 2.0 | 0.0 | 0.0 | 2.0 | -0.04408386526186264 | Stabilising | -1.639 | Destabilising | -0.2794543904518329 | 12 | 0.0718562874251497 | H | helix | 1.1666666666666667 | 6.7 | CYS | -1.148 | -0.9456342668863261 | 9 | 9 | -1.221 | -1.124 | 9:9 | 147/150 | C:S | 87 | 0.9157894736842105 | 91 | effect | 1.02 | 0.5730337078651685 | Stabilising | SER | 0 | pnca_complex.pdb | ||||||||||||||||||
| 328 | C138W | C | 138 | W | A | PZA | 3.282 | -1.048 | Destabilising | 0.943 | Stabilising | -0.2708010335917312 | 0.4228699551569506 | C138 | CA138 | -1.71951 | -72.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -2.0 | 0.0 | 0.0 | -3.0 | -12.0 | 0.0 | -2.0 | -16.0 | -0.33059870799046376 | Stabilising | -1.165 | Destabilising | -0.19863597612958225 | 12 | 0.0718562874251497 | H | helix | 1.1666666666666667 | 6.7 | CYS | -1.148 | -0.9456342668863261 | 9 | 9 | -1.221 | -1.124 | 9:9 | 147/150 | C:S | 91 | 0.9578947368421052 | 95 | effect | -0.99 | -0.2591623036649215 | Destabilising | TRP | 0 | pnca_complex.pdb | ||||||||||||||||||
| 329 | V139L | V | 139 | L | A | PZA | 5.113 | -0.462 | Destabilising | -0.504 | Destabilising | -0.1193798449612403 | -0.1276595744680851 | V139 | VA139 | -1.24107 | -28.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -4.0 | 0.0 | -1.0 | -3.0 | -2.0 | 0.0 | 0.0 | 0.0 | -0.23861224332846265 | Stabilising | -0.518 | Destabilising | -0.08832054560954816 | 0 | 0.0 | H | helix | 0.7333333333333334 | 9.18 | VAL | -1.171 | -0.9645799011532126 | 9 | 9 | -1.221 | -1.152 | 9:9 | 147/150 | I:V:A | 79 | 0.8315789473684211 | 85 | effect | pnca_p.val139leu | 0.0007905706482679 | 3.08639980550335 | 21.8980984766686 | 7.90481988040462e-05 | 0.781907928411257 | 3.9472675661117 | 5.63934469685405 | 143.700732785851 | 21.8981012658228 | 1.34040645979333 | 21.8894347089025 | 4.86279858821822e-06 | 5.31311371806022 | 4.52710002121826 | 207.736204499878 | 28.1227645329198 | 1.13858693465794e-07 | -0.59 | -0.1544502617801047 | Destabilising | LEU | 0 | pnca_complex.pdb |
| 330 | V139G | V | 139 | G | A | PZA | 5.113 | -2.377 | Destabilising | -0.4 | Destabilising | -0.6142118863049095 | -0.1013171225937183 | V139 | VA139 | 4.03008 | 12.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 1.0 | 0.0 | 1.0 | 0.0 | 6.0 | 0.0 | 17.0 | 25.0 | 0.14678428601606947 | Destabilising | -4.222 | Destabilising | -0.7198635976129583 | 0 | 0.0 | H | helix | 0.7333333333333334 | 9.18 | VAL | -1.171 | -0.9645799011532126 | 9 | 9 | -1.221 | -1.152 | 9:9 | 147/150 | I:V:A | 84 | 0.8842105263157894 | 91 | effect | pnca_p.val139gly | 0.000646830530401 | 3.66142892829214 | 38.9169126367817 | 0.0005578275078108 | 1.06087424525349 | 3.45133171502081 | 7.13685172053903 | 722.165073758294 | 38.9169126950654 | 1.59013838008863 | 38.9145296299157 | 5.5228318480997e-06 | 5.25783817940065 | 5.21074959149254 | 1710.75565736304 | 27.8738145664613 | 1.29490403629991e-07 | -2.37 | -0.6204188481675393 | Destabilising | GLY | 0 | pnca_complex.pdb |
| 331 | V139A | V | 139 | A | A | PZA | 5.113 | -1.598 | Destabilising | -0.537 | Destabilising | -0.4129198966408269 | -0.1360182370820668 | V139 | VA139 | 2.24246 | 2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 1.0 | 0.0 | 1.0 | 0.0 | 2.0 | 0.0 | 4.0 | 7.0 | 0.08167527444110169 | Destabilising | -2.438 | Destabilising | -0.41568627450980394 | 0 | 0.0 | H | helix | 0.7333333333333334 | 9.18 | VAL | -1.171 | -0.9645799011532126 | 9 | 9 | -1.221 | -1.152 | 9:9 | 147/150 | I:V:A | 52 | 0.5473684210526316 | 75 | effect | pnca_p.val139ala | 0.0018686215322696 | 1.58305747959306 | 4.86982245520442 | 5.59300498642966e-05 | 0.392881092301541 | 4.02935521869819 | 2.23340951898872 | 10.6183850984524 | 4.8698224852071 | 0.687513130598596 | 4.86909461472896 | 0.0001170700255588 | 3.93155428682984 | 2.07661167855124 | 11.4195822840533 | 17.6365403604529 | 2.67400952353788e-05 | -1.84 | -0.4816753926701571 | Destabilising | ALA | 0 | pnca_complex.pdb |
| 332 | V139M | V | 139 | M | A | PZA | 5.113 | -0.944 | Destabilising | -1.067 | Destabilising | -0.2439276485788113 | -0.2702634245187436 | V139 | VA139 | -0.8750100000000001 | -44.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -6.0 | 0.0 | -1.0 | -5.0 | -2.0 | 0.0 | 0.0 | 0.0 | -0.16823233100053836 | Stabilising | -1.235 | Destabilising | -0.21057118499573743 | 0 | 0.0 | H | helix | 0.7333333333333334 | 9.18 | VAL | -1.171 | -0.9645799011532126 | 9 | 9 | -1.221 | -1.152 | 9:9 | 147/150 | I:V:A | 69 | 0.7263157894736842 | 80 | effect | pnca_p.val139met | 0.000646830530401 | 3.66142892829214 | 38.9169126367816 | 0.0005578275078108 | 1.06087424525349 | 3.4513317150208 | 7.13685172054607 | 722.165073756559 | 38.9169126950654 | 1.59013838008863 | 38.9145296299157 | 5.5228318480997e-06 | 5.25783817940065 | 5.21074959149254 | 1710.75565736304 | 27.8738145664613 | 1.29490403629991e-07 | -1.0 | -0.2617801047120419 | Destabilising | MET | 0 | pnca_complex.pdb |
| 333 | R140P | R | 140 | P | A | PZA | 7.347 | -0.818 | Destabilising | -1.466 | Destabilising | -0.2113695090439276 | -0.3713272543059777 | R140 | RA140 | 6.542009999999999 | 66.0 | 36.0 | 0.0 | 0.0 | 36.0 | 0.0 | 0.0 | 0.0 | 0.0 | 6.0 | 2.0 | 2.0 | 4.0 | 0.0 | 0.0 | 0.0 | 0.0 | -3.0 | 2.0 | -8.0 | -1.0 | 6.0 | 0.0 | 6.0 | -2.0 | 0.23827424442194362 | Destabilising | -1.939 | Destabilising | -0.33060528559249786 | 58 | 0.2116788321167883 | H | helix | -1.2666666666666666 | 5.39 | ARG | -0.185 | -0.15238879736408567 | 6 | 6 | -0.411 | -0.038 | 7:5 | 147/150 | G:A:T:N:L:V:K:R:E:Y:H:F:Q | 86 | 0.9052631578947369 | 91 | effect | pnca_p.arg140pro | 0.0002156101768003 | 13.1460210125008 | 511969.848429156 | 0.90796911154963 | 113.719344731969 | 0.115600569485212 | 0.183926936276834 | 29.1287878787879 | 1.4643224129316 | inf | 0.0049931328456149 | 2.3016268790981 | 2.00455510251839 | inf | 9.2872640727157 | 0.0023075254069185 | -0.18 | -0.0471204188481675 | Destabilising | PRO | 0 | pnca_complex.pdb | |
| 334 | R140S | R | 140 | S | A | PZA | 7.347 | -1.705 | Destabilising | -1.646 | Destabilising | -0.4405684754521964 | -0.4169199594731509 | R140 | RA140 | 4.37186 | 64.0 | 36.0 | 0.0 | 0.0 | 36.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.0 | 0.0 | 0.0 | 4.0 | 0.0 | 0.0 | 0.0 | 0.0 | 1.0 | 0.0 | -3.0 | 2.0 | 6.0 | 0.0 | 6.0 | 6.0 | 0.15923265758054764 | Destabilising | -0.933 | Destabilising | -0.15907928388746803 | 58 | 0.2116788321167883 | H | helix | -1.2666666666666666 | 5.39 | ARG | -0.185 | -0.15238879736408567 | 6 | 6 | -0.411 | -0.038 | 7:5 | 147/150 | G:A:T:N:L:V:K:R:E:Y:H:F:Q | 53 | 0.5578947368421052 | 75 | effect | pnca_p.arg140ser | 7.18700589334483e-05 | -8.98740878149641 | 0.0001249735077034 | 0.940032862253634 | 119.468044435492 | -0.0752285585987745 | 4692673.51081424 | 2.42412778478352 | 0.384555509373631 | 0.0 | 1.0 | 0.0 | 0.0 | 188.544222231268 | 1.0341007080334399e-29 | 0.999999999999997 | -1.49 | -0.3900523560209424 | Destabilising | SER | 0 | pnca_complex.pdb | |
| 335 | R140G | R | 140 | G | A | PZA | 7.347 | -1.398 | Destabilising | -1.735 | Destabilising | -0.3612403100775194 | -0.4394630192502533 | R140 | RA140 | 5.02413 | 70.0 | 36.0 | 0.0 | 0.0 | 36.0 | 0.0 | 0.0 | 0.0 | 0.0 | 4.0 | 0.0 | 2.0 | 4.0 | 0.0 | 0.0 | 0.0 | 0.0 | 1.0 | 0.0 | 0.0 | 1.0 | 6.0 | 0.0 | 15.0 | 17.0 | 0.1829897507994668 | Destabilising | -1.666 | Destabilising | -0.2840579710144927 | 58 | 0.2116788321167883 | H | helix | -1.2666666666666666 | 5.39 | ARG | -0.185 | -0.15238879736408567 | 6 | 6 | -0.411 | -0.038 | 7:5 | 147/150 | G:A:T:N:L:V:K:R:E:Y:H:F:Q | 71 | 0.7473684210526316 | 85 | effect | -1.21 | -0.3167539267015707 | Destabilising | GLY | 0 | pnca_complex.pdb | ||||||||||||||||||
| 336 | R140H | R | 140 | H | A | PZA | 7.347 | -1.041 | Destabilising | -1.013 | Destabilising | -0.2689922480620155 | -0.2565856129685916 | R140 | RA140 | 2.29767 | 38.0 | 6.0 | 0.0 | 0.0 | 6.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.0 | 0.0 | 0.0 | 2.0 | 0.0 | 0.0 | 0.0 | 0.0 | -4.0 | 0.0 | -4.0 | -4.0 | -2.0 | 0.0 | -2.0 | 4.0 | 0.08368614281863941 | Destabilising | -1.276 | Destabilising | -0.2175618073316283 | 58 | 0.2116788321167883 | H | helix | -1.2666666666666666 | 5.39 | ARG | -0.185 | -0.15238879736408567 | 6 | 6 | -0.411 | -0.038 | 7:5 | 147/150 | G:A:T:N:L:V:K:R:E:Y:H:F:Q | 53 | 0.5578947368421052 | 75 | effect | -1.42 | -0.3717277486910995 | Destabilising | HIS | 0 | pnca_complex.pdb | ||||||||||||||||||
| 337 | Q141P | Q | 141 | P | A | PZA | 8.107999999999999 | 0.901 | Stabilising | -1.656 | Destabilising | 0.766156462585034 | -0.4194528875379939 | Q141 | QA141 | 5.02461 | 30.0 | -31.0 | 0.0 | 0.0 | -31.0 | 0.0 | 0.0 | 0.0 | 0.0 | 4.0 | 2.0 | 0.0 | 4.0 | 0.0 | 0.0 | 0.0 | 0.0 | 3.0 | 4.0 | -1.0 | -2.0 | -8.0 | 0.0 | -10.0 | -6.0 | 0.18300723344429956 | Destabilising | -1.835 | Destabilising | -0.3128729752770673 | 41 | 0.1822222222222222 | H | helix | -2.9 | 5.08 | GLN | -0.137 | -0.11285008237232291 | 6 | 6 | -0.332 | -0.038 | 6:5 | 147/150 | N:C:R:F:H:E:Y:Q:W:D:A:S | 79 | 0.8315789473684211 | 85 | effect | pnca_p.gln141pro | 0.0019404915912031 | 3.33727355927796 | 28.1422937171073 | 7.45865029764653e-10 | 0.542113710503027 | 6.15603976549737 | 10.8149160259451 | 96.0464157669383 | 28.1422962648557 | 1.44935953071313 | 28.1176868093208 | 1.80101596312758e-14 | 13.744482437837 | 9.60105095933572 | 112.1508500808 | 83.7298318312042 | 5.67227891121513e-20 | 1.14 | 0.6404494382022471 | Stabilising | PRO | 0 | pnca_complex.pdb |
| 338 | Q141R | Q | 141 | R | A | PZA | 8.107999999999999 | 0.765 | Stabilising | -1.581 | Destabilising | 0.6505102040816327 | -0.4004559270516717 | Q141 | QA141 | 1.88305 | -58.0 | -30.0 | 0.0 | 0.0 | -30.0 | 0.0 | 0.0 | 0.0 | 0.0 | 4.0 | 0.0 | 0.0 | 4.0 | 0.0 | 0.0 | 0.0 | 0.0 | -3.0 | 0.0 | 1.0 | -5.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.06858477990078599 | Destabilising | -0.131 | Destabilising | -0.02233589087809037 | 41 | 0.1822222222222222 | H | helix | -2.9 | 5.08 | GLN | -0.137 | -0.11285008237232291 | 6 | 6 | -0.332 | -0.038 | 6:5 | 147/150 | N:C:R:F:H:E:Y:Q:W:D:A:S | 36 | 0.37894736842105264 | 66 | effect | pnca_p.gln141arg | 0.0001437401178668 | -9.98752126245058 | 4.59700131334267e-05 | 0.942832958100734 | 139.277183325398 | -0.0717096729269461 | 144471.706314847 | 1.2119588062211 | 0.0834878586628579 | 0.0 | 1.0 | 0.0 | 0.0 | 25.8386585962163 | 1.0105682238915901e-25 | 0.999999999999746 | 0.13 | 0.0730337078651685 | Stabilising | ARG | 0 | pnca_complex.pdb | |
| 339 | T142K | T | 142 | K | A | PZA | 8.097999999999999 | -0.83 | Destabilising | -1.238 | Destabilising | -0.214470284237726 | -0.3135764944275582 | T142 | TA142 | 3.49705 | -82.0 | -48.0 | 0.0 | -2.0 | -46.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.0 | 0.0 | 2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 1.0 | 0.0 | 3.0 | -2.0 | -6.0 | 0.0 | -4.0 | -6.0 | 0.1273701731510282 | Destabilising | -5.128 | Destabilising | -0.8743393009377664 | 0 | 0.0 | H | helix | -0.7999999999999999 | 8.33 | THR | -0.892 | -0.7347611202635914 | 8 | 8 | -0.993 | -0.827 | 9:8 | 147/150 | S:E:T | 91 | 0.9578947368421052 | 95 | effect | pnca_p.thr142lys | 0.0002156101768003 | 13.1460210125009 | 511969.848429232 | 0.907969111549634 | 113.719344731975 | 0.115600569485207 | 0.183926936276726 | 29.1287878787879 | 1.4643224129316 | inf | 0.0049931328456149 | 2.3016268790981 | 2.00455510251839 | inf | 9.2872640727157 | 0.0023075254069185 | -0.82 | -0.2146596858638743 | Destabilising | LYS | 0 | pnca_complex.pdb | |
| 340 | T142A | T | 142 | A | A | PZA | 8.097999999999999 | -0.5720000000000001 | Destabilising | -1.983 | Destabilising | -0.1478036175710594 | -0.5022796352583587 | T142 | TA142 | 2.85915 | 4.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.0 | 0.0 | 2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 4.0 | 0.0 | 4.0 | 0.0 | 6.0 | 0.0 | 2.0 | 9.0 | 0.10413646661179059 | Destabilising | -2.289 | Destabilising | -0.3902813299232737 | 0 | 0.0 | H | helix | -0.7999999999999999 | 8.33 | THR | -0.892 | -0.7347611202635914 | 8 | 8 | -0.993 | -0.827 | 9:8 | 147/150 | S:E:T | 80 | 0.8421052631578947 | 91 | effect | pnca_p.thr142ala | 0.0005749604714675 | 2.6796663501904 | 14.5802277940117 | 0.0010245352377103 | 0.816050632122411 | 3.28370108999369 | 3.35697961122189 | 99.5538692592404 | 14.5802781289507 | 1.16376580853041 | 14.5801759034061 | 0.0005075351447614 | 3.29453387923245 | 2.60435121163486 | 147.676327006136 | 15.0663448164144 | 0.0001037975122989 | -0.73 | -0.1910994764397905 | Destabilising | ALA | 0 | pnca_complex.pdb |
| 341 | T142R | T | 142 | R | A | PZA | 8.097999999999999 | -0.733 | Destabilising | -1.267 | Destabilising | -0.1894056847545219 | -0.3209219858156029 | T142 | TA142 | 5.15889 | -106.0 | -34.0 | 0.0 | 0.0 | -34.0 | 0.0 | 0.0 | 0.0 | 0.0 | -2.0 | 0.0 | 4.0 | -4.0 | 0.0 | 0.0 | 0.0 | 0.0 | -9.0 | 0.0 | 0.0 | -9.0 | -10.0 | 0.0 | -14.0 | -4.0 | 0.1878980033362714 | Destabilising | -4.739 | Destabilising | -0.8080136402387041 | 0 | 0.0 | H | helix | -0.7999999999999999 | 8.33 | THR | -0.892 | -0.7347611202635914 | 8 | 8 | -0.993 | -0.827 | 9:8 | 147/150 | S:E:T | 91 | 0.9578947368421052 | 95 | effect | -0.89 | -0.2329842931937173 | Destabilising | ARG | 0 | pnca_complex.pdb | ||||||||||||||||||
| 342 | T142P | T | 142 | P | A | PZA | 8.097999999999999 | -0.706 | Destabilising | -1.638 | Destabilising | -0.1824289405684754 | -0.4148936170212766 | T142 | TA142 | 6.72536 | 4.0 | -25.0 | 0.0 | 0.0 | -25.0 | 0.0 | 0.0 | 0.0 | 0.0 | 4.0 | 2.0 | 2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 4.0 | 4.0 | 0.0 | -2.0 | 6.0 | 0.0 | -2.0 | 4.0 | 0.24495225052630046 | Destabilising | -4.677 | Destabilising | -0.7974424552429666 | 0 | 0.0 | H | helix | -0.7999999999999999 | 8.33 | THR | -0.892 | -0.7347611202635914 | 8 | 8 | -0.993 | -0.827 | 9:8 | 147/150 | S:E:T | 92 | 0.968421052631579 | 95 | effect | pnca_p.thr142pro | 0.0001437401178668 | 13.1456002256242 | 511754.463554492 | 0.924803768447115 | 139.277183326822 | 0.0943844491367787 | 0.0001628371344392 | 19.411022297013 | 1.28804840845689 | inf | 0.0292235860951597 | 1.53426649183163 | 0.91081598550184 | inf | 4.73122070382274 | 0.0296198560706035 | -0.54 | -0.1413612565445026 | Destabilising | PRO | 0 | pnca_complex.pdb | |
| 343 | T142M | T | 142 | M | A | PZA | 8.097999999999999 | 0.175 | Stabilising | -1.836 | Destabilising | 0.1488095238095238 | -0.4650455927051671 | T142 | TA142 | -0.8869389999999999 | -56.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.0 | 0.0 | 2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -3.0 | 0.0 | 1.0 | -4.0 | 0.0 | 0.0 | 0.0 | 0.0 | -0.1705258401907252 | Stabilising | -1.977 | Destabilising | -0.3370843989769821 | 0 | 0.0 | H | helix | -0.7999999999999999 | 8.33 | THR | -0.892 | -0.7347611202635914 | 8 | 8 | -0.993 | -0.827 | 9:8 | 147/150 | S:E:T | 85 | 0.8947368421052632 | 91 | effect | pnca_p.thr142met | 0.0002156101768003 | 2.27260607808817 | 9.70465898653051 | 0.0634455902260899 | 1.22442760158496 | 1.8560559033024 | 0.929172866365547 | 208.881603004778 | 9.70466975178797 | 0.986980761010679 | 9.70194990589383 | 0.0776844925942494 | 1.10966566656461 | 0.504888890842109 | 570.372842410328 | 2.29168245016684 | 0.130068862702538 | -0.23 | -0.0602094240837696 | Destabilising | MET | 0 | pnca_complex.pdb |
| 344 | A143V | A | 143 | V | A | PZA | 10.807 | -0.622 | Destabilising | -1.168 | Destabilising | -0.1607235142118863 | -0.2958459979736575 | A143 | AA143 | 0.113853 | -8.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -12.0 | 0.0 | -6.0 | -6.0 | -2.0 | 0.0 | -2.0 | -7.0 | 0.004146774087806584 | Destabilising | -1.998 | Destabilising | -0.34066496163682863 | 0 | 0.0 | H | helix | -0.8000000000000002 | 8.82 | ALA | -0.834 | -0.6869851729818781 | 8 | 8 | -0.955 | -0.779 | 9:8 | 147/150 | I:C:V:S:A:T | -16 | -0.17204301075268819 | 57 | neutral | pnca_p.ala143val | 0.0003593502946672 | -10.9877909019996 | 1.69068633684891e-05 | 0.939691219428539 | 145.229797681912 | -0.0756579646696575 | 60.3389082676124 | 0.484657419083649 | -0.314565134742567 | 0.0 | 0.596111875058711 | 0.224672226566594 | 0.0 | 5.29224350433385 | 0.177777263899814 | 0.673290424524484 | -0.56 | -0.1465968586387434 | Destabilising | VAL | 0 | pnca_complex.pdb | |
| 345 | A143D | A | 143 | D | A | PZA | 10.807 | -3.46 | Destabilising | 0.346 | Stabilising | -0.8940568475452196 | 0.1551569506726457 | A143 | AA143 | 5.46827 | -14.0 | -46.0 | 0.0 | -2.0 | -44.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -9.0 | 0.0 | -1.0 | -8.0 | -6.0 | 0.0 | -4.0 | -3.0 | 0.19916629637453653 | Destabilising | -5.865 | Destabilising | -1.0 | 0 | 0.0 | H | helix | -0.8000000000000002 | 8.82 | ALA | -0.834 | -0.6869851729818781 | 8 | 8 | -0.955 | -0.779 | 9:8 | 147/150 | I:C:V:S:A:T | 84 | 0.8842105263157894 | 91 | effect | pnca_p.ala143asp | 0.0001437401178668 | 1.57903938912402 | 4.85029432717734 | 0.264247566376723 | 1.41439286276584 | 1.11640791656443 | 0.191756076673654 | 122.683760399096 | 4.85029436501262 | 0.685768096792206 | 4.84956447904112 | 0.312734154310187 | 0.504824686014995 | 0.061763864579114 | 379.558337204203 | 0.0881192621863332 | 0.766581879696361 | -1.17 | -0.306282722513089 | Destabilising | ASP | 0 | pnca_complex.pdb |
| 346 | A143G | A | 143 | G | A | PZA | 10.807 | -2.08 | Destabilising | -0.868 | Destabilising | -0.537467700258398 | -0.2198581560283688 | A143 | AA143 | 2.31533 | 2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.0 | 0.0 | 5.0 | 18.0 | 0.08432935845977899 | Destabilising | -3.708 | Destabilising | -0.6322250639386189 | 0 | 0.0 | H | helix | -0.8000000000000002 | 8.82 | ALA | -0.834 | -0.6869851729818781 | 8 | 8 | -0.955 | -0.779 | 9:8 | 147/150 | I:C:V:S:A:T | 72 | 0.7578947368421053 | 85 | effect | pnca_p.ala143gly | 0.0003593502946672 | 14.1468726004037 | 1392863.97690657 | 0.922400595820385 | 145.229797685252 | 0.0974102617085742 | 0.390278156381537 | 48.5888795282224 | 1.68653688423854 | inf | 0.0001456121755417 | 3.83680230943558 | 4.44801917882778 | inf | 18.7541888696359 | 1.4869638142509e-05 | -2.04 | -0.5340314136125655 | Destabilising | GLY | 0 | pnca_complex.pdb | |
| 347 | A143T | A | 143 | T | A | PZA | 10.807 | -2.359 | Destabilising | 0.07 | Stabilising | -0.6095607235142119 | 0.0313901345291479 | A143 | AA143 | 0.4067679999999999 | -8.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -10.0 | 0.0 | -4.0 | -8.0 | -6.0 | 0.0 | -6.0 | -5.0 | 0.014815375986130431 | Destabilising | -2.811 | Destabilising | -0.4792838874680307 | 0 | 0.0 | H | helix | -0.8000000000000002 | 8.82 | ALA | -0.834 | -0.6869851729818781 | 8 | 8 | -0.955 | -0.779 | 9:8 | 147/150 | I:C:V:S:A:T | 47 | 0.49473684210526314 | 71 | effect | pnca_p.ala143thr | 0.0001437401178668 | 1.57903938912401 | 4.85029432717732 | 0.264247566376724 | 1.41439286276584 | 1.11640791656443 | 0.191756076673653 | 122.683760399095 | 4.85029436501262 | 0.685768096792206 | 4.84956447904112 | 0.312734154310187 | 0.504824686014995 | 0.061763864579114 | 379.558337204203 | 0.0881192621863332 | 0.766581879696361 | -1.46 | -0.3821989528795811 | Destabilising | THR | 0 | pnca_complex.pdb |
| 348 | A143P | A | 143 | P | A | PZA | 10.807 | -1.416 | Destabilising | -0.732 | Destabilising | -0.365891472868217 | -0.1854103343465045 | A143 | AA143 | 2.35082 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.0 | 2.0 | -2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 3.0 | 4.0 | 1.0 | -2.0 | -2.0 | 0.0 | -2.0 | -5.0 | 0.0856219815121031 | Destabilising | -3.997 | Destabilising | -0.6815004262574594 | 0 | 0.0 | H | helix | -0.8000000000000002 | 8.82 | ALA | -0.834 | -0.6869851729818781 | 8 | 8 | -0.955 | -0.779 | 9:8 | 147/150 | I:C:V:S:A:T | 85 | 0.8947368421052632 | 91 | effect | -0.21 | -0.0549738219895288 | Destabilising | PRO | 0 | pnca_complex.pdb | ||||||||||||||||||
| 349 | D145E | D | 145 | E | A | PZA | 11.649 | -0.148 | Destabilising | -1.031 | Destabilising | -0.0382428940568475 | -0.261144883485309 | D145 | DA145 | -0.4769 | -10.0 | 4.0 | 0.0 | 0.0 | 4.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.0 | 0.0 | -2.0 | 4.0 | 0.0 | 0.0 | 0.0 | 0.0 | -3.0 | 0.0 | -2.0 | -1.0 | 0.0 | 0.0 | 2.0 | -2.0 | -0.09169037914327463 | Stabilising | -0.323 | Destabilising | -0.05507246376811594 | 33 | 0.1709844559585492 | H | helix | -1.7333333333333334 | 4.71 | ASP | -1.092 | -0.899505766062603 | 9 | 9 | -1.152 | -1.062 | 9:9 | 147/150 | S:E:A:D:K | 70 | 0.7368421052631579 | 85 | effect | pnca_p.asp145glu | 7.18700589334483e-05 | 12.145153838726 | 188179.926264557 | 0.919026337424219 | 119.468044436206 | 0.101660271548274 | 5.01153666065157e-06 | 9.70142977291842 | 0.986835744238421 | inf | 0.170978870202674 | 0.767057556984365 | 0.124324963210678 | inf | 0.763784339928386 | 0.382146811758261 | -0.78 | -0.2041884816753927 | Destabilising | GLU | 0 | pnca_complex.pdb | |
| 350 | D145Y | D | 145 | Y | A | PZA | 11.649 | -0.409 | Destabilising | -1.689 | Destabilising | -0.1056847545219638 | -0.4278115501519757 | D145 | DA145 | -0.814413 | -38.0 | 28.0 | 0.0 | 0.0 | 28.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -4.0 | 6.0 | 0.0 | 0.0 | 0.0 | 0.0 | -1.0 | 0.0 | 0.0 | -2.0 | -2.0 | 0.0 | -2.0 | -2.0 | -0.15658175036530034 | Stabilising | -0.858 | Destabilising | -0.1462915601023018 | 33 | 0.1709844559585492 | H | helix | -1.7333333333333334 | 4.71 | ASP | -1.092 | -0.899505766062603 | 9 | 9 | -1.152 | -1.062 | 9:9 | 147/150 | S:E:A:D:K | 82 | 0.8631578947368421 | 91 | effect | pnca_p.asp145tyr | 7.18700589334483e-05 | 12.1451538387265 | 188179.926264644 | 0.919026337424236 | 119.468044436235 | 0.101660271548254 | 5.01153666062444e-06 | 9.70142977291842 | 0.986835744238421 | inf | 0.170978870202674 | 0.767057556984365 | 0.124324963210678 | inf | 0.763784339928386 | 0.382146811758261 | -1.05 | -0.274869109947644 | Destabilising | TYR | 0 | pnca_complex.pdb | |
| 351 | A146V | A | 146 | V | A | PZA | 14.858 | -0.425 | Destabilising | -1.712 | Destabilising | -0.1098191214470284 | -0.4336372847011145 | A146 | AA146 | 0.463909 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -9.0 | 0.0 | -3.0 | -8.0 | -4.0 | 0.0 | -2.0 | -5.0 | 0.01689657558694338 | Destabilising | -2.215 | Destabilising | -0.3776641091219096 | 0 | 0.0 | H | helix | 0.8333333333333334 | 7.08 | ALA | -0.895 | -0.7372322899505767 | 8 | 8 | -0.993 | -0.827 | 9:8 | 147/150 | G:S:A | 63 | 0.6631578947368421 | 80 | effect | pnca_p.ala146val | 0.0010061808250682 | 4.14904442894259 | 63.3734135554618 | 6.28168511875833e-05 | 1.03675010392783 | 4.0019715582603 | 12.6188969963258 | 1151.617862186 | 63.3736263736264 | 1.8019085590898 | 63.3515540724066 | 1.2241629245587202e-09 | 8.91216077783748 | 9.50473092944164 | 2653.71554384332 | 51.5211006732107 | 7.08317026236427e-13 | -0.75 | -0.1963350785340314 | Destabilising | VAL | 0 | pnca_complex.pdb |
| 352 | A146E | A | 146 | E | A | PZA | 14.858 | -2.184 | Destabilising | 0.284 | Stabilising | -0.5643410852713179 | 0.1273542600896861 | A146 | AA146 | 3.30206 | -36.0 | -46.0 | 0.0 | -2.0 | -44.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -6.0 | 0.0 | -2.0 | -7.0 | -10.0 | 0.0 | -8.0 | -9.0 | 0.12026821290947633 | Destabilising | -5.327 | Destabilising | -0.9082693947144075 | 0 | 0.0 | H | helix | 0.8333333333333334 | 7.08 | ALA | -0.895 | -0.7372322899505767 | 8 | 8 | -0.993 | -0.827 | 9:8 | 147/150 | G:S:A | 75 | 0.7894736842105263 | 85 | effect | pnca_p.ala146glu | 0.0001437401178668 | 13.1456002256226 | 511754.463553649 | 0.924803768447062 | 139.277183326707 | 0.0943844491368447 | 0.0001628371344419 | 19.411022297013 | 1.28804840845689 | inf | 0.0292235860951597 | 1.53426649183163 | 0.91081598550184 | inf | 4.73122070382274 | 0.0296198560706035 | -0.93 | -0.243455497382199 | Destabilising | GLU | 0 | pnca_complex.pdb | |
| 353 | A146T | A | 146 | T | A | PZA | 14.858 | -2.074 | Destabilising | -0.252 | Destabilising | -0.5359173126614987 | -0.0638297872340425 | A146 | AA146 | 1.48094 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -2.0 | 0.0 | -4.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -5.0 | 0.0 | -1.0 | -4.0 | -6.0 | 0.0 | -2.0 | -7.0 | 0.05393905841388705 | Destabilising | -2.71 | Destabilising | -0.4620630861040068 | 0 | 0.0 | H | helix | 0.8333333333333334 | 7.08 | ALA | -0.895 | -0.7372322899505767 | 8 | 8 | -0.993 | -0.827 | 9:8 | 147/150 | G:S:A | 53 | 0.5578947368421052 | 75 | effect | pnca_p.ala146thr | 0.0007187005893344 | 1.9863491292074 | 7.28887438834092 | 0.0021008470164788 | 0.645842738542518 | 3.07559257179235 | 2.08051219809968 | 28.5295272509804 | 7.28887484197219 | 0.862660492976905 | 7.28728068125885 | 0.0027830995390782 | 2.55547126060833 | 1.72659076531017 | 35.1741774538487 | 10.1421736186998 | 0.0014491518456837 | -1.44 | -0.3769633507853403 | Destabilising | THR | 0 | pnca_complex.pdb |
| 354 | A146P | A | 146 | P | A | PZA | 14.858 | -1.233 | Destabilising | -1.497 | Destabilising | -0.3186046511627906 | -0.3791793313069908 | A146 | AA146 | 3.10964 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.0 | 2.0 | -2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -1.0 | 4.0 | -5.0 | -4.0 | -4.0 | 0.0 | -2.0 | -5.0 | 0.11325985766213333 | Destabilising | -3.961 | Destabilising | -0.6753623188405796 | 0 | 0.0 | H | helix | 0.8333333333333334 | 7.08 | ALA | -0.895 | -0.7372322899505767 | 8 | 8 | -0.993 | -0.827 | 9:8 | 147/150 | G:S:A | 79 | 0.8315789473684211 | 85 | effect | pnca_p.ala146pro | 7.18700589334483e-05 | 12.1451538387267 | 188179.926264681 | 0.919026337424242 | 119.468044436246 | 0.101660271548246 | 5.01153666061373e-06 | 9.70142977291842 | 0.986835744238421 | inf | 0.170978870202674 | 0.767057556984365 | 0.124324963210678 | inf | 0.763784339928386 | 0.382146811758261 | 0.02 | 0.0112359550561797 | Stabilising | PRO | 0 | pnca_complex.pdb | |
| 355 | R148C | R | 148 | C | A | PZA | 14.673 | -0.2769999999999999 | Destabilising | -0.94 | Destabilising | -0.0715762273901808 | -0.238095238095238 | R148 | RA148 | 1.80299 | 38.0 | 22.0 | 0.0 | 0.0 | 22.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.0 | 0.0 | 0.0 | 0.0 | 0.0 | -3.0 | 0.0 | -7.0 | 3.0 | 6.0 | 0.0 | 6.0 | 4.0 | 0.06566882043138426 | Destabilising | -0.806 | Destabilising | -0.13742540494458652 | 156 | 0.5693430656934306 | H | helix | -1.2666666666666666 | 3.5 | ARG | 1.306 | 0.4185897435897436 | 1 | 1 | 0.842 | 1.712 | 2:1 | 146/150 | I:R:K:N:L:Q:E:H:W:D:M:S:A:G:T | 39 | 0.4105263157894737 | 66 | effect | 0.84 | 0.4719101123595505 | Stabilising | CYS | 0 | pnca_complex.pdb | ||||||||||||||||||
| 356 | N149V | N | 149 | V | A | PZA | 16.469 | -0.064 | Destabilising | -0.706 | Destabilising | -0.0165374677002583 | -0.1788247213779128 | N149 | NA149 | 0.446809 | 16.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -3.0 | 0.0 | -3.0 | 0.0 | 0.0 | 0.0 | 0.0 | -2.0 | 0.016273756364775384 | Destabilising | -0.317 | Destabilising | -0.054049445865302644 | 71 | 0.3641025641025641 | T | loop | -2.8000000000000003 | 3.68 | ASN | 0.97 | 0.3108974358974359 | 1 | 1 | 0.59 | 1.183 | 3:1 | 146/150 | Q:E:Y:H:F:C:R:K:L:N:G:M:S:A:D | -28 | -0.3010752688172043 | 61 | neutral | pnca_p.asn149val | 7.18700589334483e-05 | 12.1451538387265 | 188179.926264649 | 0.919026337424236 | 119.468044436237 | 0.101660271548253 | 5.01153666062283e-06 | 9.70142977291842 | 0.986835744238421 | inf | 0.170978870202674 | 0.767057556984365 | 0.124324963210678 | inf | 0.763784339928386 | 0.382146811758261 | -0.26 | -0.0680628272251308 | Destabilising | VAL | 0 | pnca_complex.pdb | |
| 357 | N149S | N | 149 | S | A | PZA | 16.469 | -0.42 | Destabilising | -0.233 | Destabilising | -0.1085271317829457 | -0.0590172239108409 | N149 | NA149 | 0.889156 | 18.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.03238499697695933 | Destabilising | -0.206 | Destabilising | -0.03512361466325661 | 71 | 0.3641025641025641 | T | loop | -2.8000000000000003 | 3.68 | ASN | 0.97 | 0.3108974358974359 | 1 | 1 | 0.59 | 1.183 | 3:1 | 146/150 | Q:E:Y:H:F:C:R:K:L:N:G:M:S:A:D | -76 | -0.8172043010752689 | 87 | neutral | 0.47 | 0.2640449438202247 | Stabilising | SER | 0 | pnca_complex.pdb | ||||||||||||||||||
| 358 | N149D | N | 149 | D | A | PZA | 16.469 | 0.469 | Stabilising | -0.043 | Destabilising | 0.3988095238095238 | -0.0108915906788247 | N149 | NA149 | 1.84951 | 0.0 | -5.0 | 0.0 | 0.0 | -5.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.0 | 0.06736318009309508 | Destabilising | -0.656 | Destabilising | -0.11184995737425404 | 71 | 0.3641025641025641 | T | loop | -2.8000000000000003 | 3.68 | ASN | 0.97 | 0.3108974358974359 | 1 | 1 | 0.59 | 1.183 | 3:1 | 146/150 | Q:E:Y:H:F:C:R:K:L:N:G:M:S:A:D | -34 | -0.3655913978494624 | 66 | neutral | 0.16 | 0.0898876404494382 | Stabilising | ASP | 0 | pnca_complex.pdb | ||||||||||||||||||
| 359 | G150D | G | 150 | D | A | PZA | 21.16 | -0.785 | Destabilising | 1.269 | Stabilising | -0.2028423772609819 | 0.5690582959641256 | G150 | GA150 | 3.5588800000000003 | -12.0 | -18.0 | 0.0 | -2.0 | -16.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -1.0 | 0.0 | -3.0 | 0.0 | -2.0 | 0.0 | -3.0 | -9.0 | 0.12962215633855143 | Destabilising | -0.949 | Destabilising | -0.1618073316283035 | 63 | 0.6057692307692307 | T | loop | -0.0333333333333334 | 3.34 | GLY | -0.715 | -0.5889621087314663 | 8 | 8 | -0.872 | -0.615 | 8:7 | 146/150 | G:E:H:Q:L:D:R | 51 | 0.5368421052631579 | 75 | effect | pnca_p.gly150asp | 7.18700589334483e-05 | 12.1451538387254 | 188179.926264446 | 0.9190263374242 | 119.468044436172 | 0.101660271548298 | 5.01153666068333e-06 | 9.70142977291842 | 0.986835744238421 | inf | 0.170978870202674 | 0.767057556984365 | 0.124324963210678 | inf | 0.763784339928386 | 0.382146811758261 | -0.34 | -0.0890052356020942 | Destabilising | ASP | 0 | pnca_complex.pdb | |
| 360 | L151S | L | 151 | S | A | PZA | 18.507 | -2.523 | Destabilising | 0.079 | Stabilising | -0.6519379844961241 | 0.0354260089686098 | L151 | LA151 | 3.86505 | 18.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -2.0 | 0.0 | 0.0 | 0.0 | 0.0 | -3.0 | 0.0 | -3.0 | 0.0 | 10.0 | 0.0 | 4.0 | 8.0 | 0.1407735341894973 | Destabilising | -2.175 | Destabilising | -0.3708439897698209 | 10 | 0.0497512437810945 | - | loop | 1.7333333333333332 | 5.31 | LEU | -0.04 | -0.032948929159802305 | 5 | 5 | -0.244 | 0.083 | 6:5 | 145/150 | Q:F:Y:I:R:L:V:M:W | 57 | 0.6 | 75 | effect | pnca_p.leu151ser | 0.0010061808250682 | 2.16984855308098 | 8.7569577260426 | 0.0001010560982854 | 0.558082575591327 | 3.888042106998 | 3.02252426488638 | 28.523060095548 | 8.75696202531646 | 0.942353466387901 | 8.75484033225151 | 0.0001077244819236 | 3.96768558587492 | 2.63211458386555 | 33.2911283333248 | 18.8086142562631 | 1.44512946670157e-05 | -2.07 | -0.5418848167539266 | Destabilising | SER | 0 | pnca_complex.pdb |
| 361 | L151W | L | 151 | W | A | PZA | 18.507 | -1.831 | Destabilising | -0.7140000000000001 | Destabilising | -0.4731266149870801 | -0.1808510638297872 | L151 | LA151 | 2.01402 | -22.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -11.0 | 0.0 | -3.0 | -10.0 | -10.0 | 0.0 | -16.0 | -2.0 | 0.07335499238776506 | Destabilising | -0.33 | Destabilising | -0.05626598465473146 | 10 | 0.0497512437810945 | - | loop | 1.7333333333333332 | 5.31 | LEU | -0.04 | -0.032948929159802305 | 5 | 5 | -0.244 | 0.083 | 6:5 | 145/150 | Q:F:Y:I:R:L:V:M:W | 20 | 0.21052631578947367 | 63 | effect | pnca_p.leu151trp | 7.18700589334483e-05 | 12.1451538387255 | 188179.926264453 | 0.919026337424201 | 119.468044436174 | 0.101660271548297 | 5.01153666068148e-06 | 9.70142977291842 | 0.986835744238421 | inf | 0.170978870202674 | 0.767057556984365 | 0.124324963210678 | inf | 0.763784339928386 | 0.382146811758261 | -2.26 | -0.5916230366492147 | Destabilising | TRP | 0 | pnca_complex.pdb | |
| 362 | L151V | L | 151 | V | A | PZA | 18.507 | -1.74 | Destabilising | -1.269 | Destabilising | -0.4496124031007751 | -0.3214285714285714 | L151 | LA151 | 1.09305 | 18.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -5.0 | 0.0 | -1.0 | -4.0 | -2.0 | 0.0 | -2.0 | 2.0 | 0.03981126028015938 | Destabilising | -1.108 | Destabilising | -0.18891730605285592 | 10 | 0.0497512437810945 | - | loop | 1.7333333333333332 | 5.31 | LEU | -0.04 | -0.032948929159802305 | 5 | 5 | -0.244 | 0.083 | 6:5 | 145/150 | Q:F:Y:I:R:L:V:M:W | 31 | 0.3263157894736842 | 66 | effect | -1.93 | -0.5052356020942408 | Destabilising | VAL | 0 | pnca_complex.pdb | ||||||||||||||||||
| 363 | T153I | T | 153 | I | A | PZA | 15.544 | 0.532 | Stabilising | -2.111 | Destabilising | 0.4523809523809524 | -0.5347011144883485 | T153 | TA153 | -0.698929 | -20.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.0 | 0.0 | 2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -11.0 | 0.0 | -5.0 | -8.0 | -2.0 | 0.0 | -4.0 | -2.0 | -0.1343784126739983 | Stabilising | -1.456 | Destabilising | -0.24825234441602725 | 12 | 0.0697674418604651 | E | strand | -1.1333333333333335 | 5.38 | THR | -0.188 | -0.15485996705107086 | 6 | 6 | -0.411 | -0.038 | 7:5 | 144/150 | V:C:A:S:T | 43 | 0.45263157894736844 | 71 | effect | -0.46 | -0.1204188481675392 | Destabilising | ILE | 0 | pnca_complex.pdb | ||||||||||||||||||
| 364 | T153P | T | 153 | P | A | PZA | 15.544 | -0.926 | Destabilising | -2.212 | Destabilising | -0.2392764857881136 | -0.5602836879432623 | T153 | TA153 | 3.60938 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.0 | 0.0 | 2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -6.0 | 0.0 | -6.0 | -2.0 | 6.0 | 0.0 | 8.0 | 0.0 | 0.13146147626366742 | Destabilising | -4.405 | Destabilising | -0.7510656436487638 | 12 | 0.0697674418604651 | E | strand | -1.1333333333333335 | 5.38 | THR | -0.188 | -0.15485996705107086 | 6 | 6 | -0.411 | -0.038 | 7:5 | 144/150 | V:C:A:S:T | 70 | 0.7368421052631579 | 85 | effect | pnca_p.thr153pro | 7.18700589334483e-05 | 12.1451538387264 | 188179.926264634 | 0.919026337424234 | 119.468044436232 | 0.101660271548256 | 5.0115366606273e-06 | 9.70142977291842 | 0.986835744238421 | inf | 0.170978870202674 | 0.767057556984365 | 0.124324963210678 | inf | 0.763784339928386 | 0.382146811758261 | -0.6 | -0.1570680628272251 | Destabilising | PRO | 0 | pnca_complex.pdb | |
| 365 | R154G | R | 154 | G | A | PZA | 15.259 | -1.337 | Destabilising | -2.707 | Destabilising | -0.3454780361757106 | -0.6856636271529888 | R154 | RA154 | 4.31639 | 66.0 | 28.0 | 0.0 | 4.0 | 24.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.0 | 0.0 | 0.0 | 2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -1.0 | 1.0 | 10.0 | 0.0 | 11.0 | 21.0 | 0.15721231943705885 | Destabilising | -1.992 | Destabilising | -0.33964194373401535 | 60 | 0.218978102189781 | E | strand | -0.3333333333333333 | 5.21 | ARG | 1.542 | 0.49423076923076925 | 1 | 1 | 0.842 | 1.712 | 2:1 | 144/150 | T:W:E:F:Q:V:N:L:R:I:C:S:A:D:Y:H | 73 | 0.7684210526315789 | 85 | effect | pnca_p.arg154gly | 0.0011499209429351 | 3.530334177178 | 34.1353729715529 | 2.90603701922833e-06 | 0.754772029037902 | 4.6773516258652 | 9.53076902254824 | 217.507266299408 | 34.1357293868922 | 1.53320918696851 | 34.1417078158954 | 1.5011843627935802e-09 | 8.82356596809844 | 7.82937374234326 | 309.275011521707 | 51.1500808664409 | 8.55671558873616e-13 | -1.71 | -0.4476439790575916 | Destabilising | GLY | 0 | pnca_complex.pdb |
| 366 | R154W | R | 154 | W | A | PZA | 15.259 | -0.436 | Destabilising | -1.381 | Destabilising | -0.1126614987080103 | -0.3497973657548126 | R154 | RA154 | 2.7463 | 10.0 | 28.0 | 0.0 | 4.0 | 24.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.0 | 0.0 | 0.0 | 2.0 | 0.0 | 0.0 | 0.0 | 0.0 | -4.0 | 0.0 | -3.0 | -1.0 | 10.0 | 0.0 | 4.0 | 6.0 | 0.10002622396724918 | Destabilising | -0.368 | Destabilising | -0.06274509803921569 | 60 | 0.218978102189781 | E | strand | -0.3333333333333333 | 5.21 | ARG | 1.542 | 0.49423076923076925 | 1 | 1 | 0.842 | 1.712 | 2:1 | 144/150 | T:W:E:F:Q:V:N:L:R:I:C:S:A:D:Y:H | 56 | 0.5894736842105263 | 75 | effect | -0.6 | -0.1570680628272251 | Destabilising | TRP | 0 | pnca_complex.pdb | ||||||||||||||||||
| 367 | R154S | R | 154 | S | A | PZA | 15.259 | -2.044 | Destabilising | -2.614 | Destabilising | -0.5281653746770025 | -0.6621073961499493 | R154 | RA154 | 2.37151 | 60.0 | 28.0 | 0.0 | 4.0 | 24.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 3.0 | 0.0 | 0.0 | 3.0 | 10.0 | 0.0 | 4.0 | 6.0 | 0.08637555634874962 | Destabilising | -1.076 | Destabilising | -0.183461210571185 | 60 | 0.218978102189781 | E | strand | -0.3333333333333333 | 5.21 | ARG | 1.542 | 0.49423076923076925 | 1 | 1 | 0.842 | 1.712 | 2:1 | 144/150 | T:W:E:F:Q:V:N:L:R:I:C:S:A:D:Y:H | 55 | 0.5789473684210527 | 75 | effect | -1.74 | -0.4554973821989529 | Destabilising | SER | 0 | pnca_complex.pdb | ||||||||||||||||||
| 368 | V155L | V | 155 | L | A | PZA | 12.302 | -1.141 | Destabilising | -2.349 | Destabilising | -0.2948320413436692 | -0.594984802431611 | V155 | VA155 | -0.756754 | -34.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -6.0 | 0.0 | -2.0 | -4.0 | -8.0 | 0.0 | -8.0 | -2.0 | -0.14549603937552874 | Stabilising | -1.463 | Destabilising | -0.2494458653026428 | 0 | 0.0 | E | strand | 1.1666666666666667 | 7.97 | VAL | -0.482 | -0.3970345963756178 | 7 | 7 | -0.615 | -0.411 | 7:7 | 144/150 | F:Y:I:L:V | -14 | -0.15053763440860216 | 57 | neutral | pnca_p.val155leu | 7.18700589334483e-05 | 12.1451538387262 | 188179.926264586 | 0.919026337424224 | 119.468044436215 | 0.101660271548268 | 5.01153666064309e-06 | 9.70142977291842 | 0.986835744238421 | inf | 0.170978870202674 | 0.767057556984365 | 0.124324963210678 | inf | 0.763784339928386 | 0.382146811758261 | -1.05 | -0.274869109947644 | Destabilising | LEU | 0 | pnca_complex.pdb | |
| 369 | V155A | V | 155 | A | A | PZA | 12.302 | -3.049 | Destabilising | -1.886 | Destabilising | -0.7878552971576227 | -0.4777102330293819 | V155 | VA155 | 3.6527 | 2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.0 | 3.0 | 0.13303928495982634 | Destabilising | -2.972 | Destabilising | -0.5067348678601875 | 0 | 0.0 | E | strand | 1.1666666666666667 | 7.97 | VAL | -0.482 | -0.3970345963756178 | 7 | 7 | -0.615 | -0.411 | 7:7 | 144/150 | F:Y:I:L:V | 54 | 0.5684210526315789 | 75 | effect | pnca_p.val155ala | 7.18700589334483e-05 | 12.1451538387262 | 188179.926264589 | 0.919026337424226 | 119.468044436217 | 0.101660271548266 | 5.0115366606409e-06 | 9.70142977291842 | 0.986835744238421 | inf | 0.170978870202674 | 0.767057556984365 | 0.124324963210678 | inf | 0.763784339928386 | 0.382146811758261 | -2.61 | -0.6832460732984293 | Destabilising | ALA | 0 | pnca_complex.pdb | |
| 370 | V155M | V | 155 | M | A | PZA | 12.302 | -1.505 | Destabilising | -2.486 | Destabilising | -0.3888888888888888 | -0.6296859169199595 | V155 | VA155 | -0.575554 | -48.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -8.0 | 0.0 | 0.0 | -8.0 | -4.0 | 0.0 | -4.0 | 0.0 | -0.11065792509420903 | Stabilising | -2.196 | Destabilising | -0.37442455242966755 | 0 | 0.0 | E | strand | 1.1666666666666667 | 7.97 | VAL | -0.482 | -0.3970345963756178 | 7 | 7 | -0.615 | -0.411 | 7:7 | 144/150 | F:Y:I:L:V | 51 | 0.5368421052631579 | 75 | effect | pnca_p.val155met | 0.0004312203536006 | 14.1472939191273 | 1393450.94022009 | 0.915018435774946 | 132.576060676167 | 0.106710773023222 | 4.1789618205157 | 58.3312262958281 | 1.7659011066874 | inf | 2.48532104922106e-05 | 4.60461750194108 | 5.71767556863798 | inf | 23.547488635408 | 1.21868387173808e-06 | -1.23 | -0.3219895287958115 | Destabilising | MET | 0 | pnca_complex.pdb | |
| 371 | V155G | V | 155 | G | A | PZA | 12.302 | -3.675 | Destabilising | -1.655 | Destabilising | -0.9496124031007752 | -0.4191995947315096 | V155 | VA155 | 5.87683 | 4.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 6.0 | 0.0 | 3.0 | 25.0 | 0.21404694090137602 | Destabilising | -4.368 | Destabilising | -0.7447570332480818 | 0 | 0.0 | E | strand | 1.1666666666666667 | 7.97 | VAL | -0.482 | -0.3970345963756178 | 7 | 7 | -0.615 | -0.411 | 7:7 | 144/150 | F:Y:I:L:V | 72 | 0.7578947368421053 | 85 | effect | pnca_p.val155gly | 0.0004312203536006 | 3.19016080361873 | 24.2923334241601 | 0.0035954281300594 | 1.09565968954934 | 2.91163472932996 | 3.91551977432402 | 465.531063220228 | 24.2923336141533 | 1.38546923679232 | 24.2833096922897 | 0.0007494070007895 | 3.12528225414311 | 2.71567844828345 | 1141.60089496884 | 14.1977442691074 | 0.0001645676755807 | -3.48 | -0.9109947643979058 | Destabilising | GLY | 0 | pnca_complex.pdb |
| 372 | L156P | L | 156 | P | A | PZA | 13.994000000000002 | -2.813 | Destabilising | -1.81 | Destabilising | -0.7268733850129199 | -0.4584599797365755 | L156 | LA156 | 2.74955 | 18.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.0 | 2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 4.0 | 2.0 | 0.0 | 2.0 | 0.0 | 0.0 | -2.0 | -2.0 | 0.10014459604163783 | Destabilising | -3.96 | Destabilising | -0.6751918158567775 | 0 | 0.0 | E | strand | 4.066666666666666 | 6.53 | LEU | 0.122 | 0.0391025641025641 | 5 | 5 | -0.147 | 0.225 | 6:4 | 144/150 | L:V:N:R:I:K:F:H:P | 63 | 0.6631578947368421 | 80 | effect | pnca_p.leu156pro | 0.0001437401178668 | 13.1456002256219 | 511754.463553313 | 0.924803768447042 | 139.277183326662 | 0.0943844491368703 | 0.000162837134443 | 19.411022297013 | 1.28804840845689 | inf | 0.0292235860951597 | 1.53426649183163 | 0.91081598550184 | inf | 4.73122070382274 | 0.0296198560706035 | -1.74 | -0.4554973821989529 | Destabilising | PRO | 0 | pnca_complex.pdb | |
| 373 | L156Q | L | 156 | Q | A | PZA | 13.994000000000002 | -2.863 | Destabilising | -0.36 | Destabilising | -0.7397932816537467 | -0.0911854103343465 | L156 | LA156 | 2.4113900000000004 | -14.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -2.0 | 0.0 | 0.0 | -2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 3.0 | 0.0 | -2.0 | 5.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.08782807275694025 | Destabilising | -4.191 | Destabilising | -0.7145780051150895 | 0 | 0.0 | E | strand | 4.066666666666666 | 6.53 | LEU | 0.122 | 0.0391025641025641 | 5 | 5 | -0.147 | 0.225 | 6:4 | 144/150 | L:V:N:R:I:K:F:H:P | 41 | 0.43157894736842106 | 71 | effect | pnca_p.leu156gln | 7.18700589334483e-05 | 12.1451538387267 | 188179.92626469 | 0.919026337424244 | 119.46804443625 | 0.101660271548243 | 5.01153666061033e-06 | 9.70142977291842 | 0.986835744238421 | inf | 0.170978870202674 | 0.767057556984365 | 0.124324963210678 | inf | 0.763784339928386 | 0.382146811758261 | -2.69 | -0.7041884816753927 | Destabilising | GLN | 0 | pnca_complex.pdb | |
| 374 | V157G | V | 157 | G | A | PZA | 13.632 | -1.896 | Destabilising | -0.926 | Destabilising | -0.489922480620155 | -0.2345491388044579 | V157 | VA157 | 1.97999 | -2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 3.0 | 0.0 | 3.0 | 0.0 | 2.0 | 0.0 | 3.0 | 17.0 | 0.07211554571347402 | Destabilising | -1.919 | Destabilising | -0.32719522591645356 | 45 | 0.2586206896551724 | E | strand | 1.5 | 4.12 | VAL | 0.579 | 0.18557692307692306 | 3 | 3 | 0.225 | 0.842 | 4:2 | 144/150 | Q:F:E:I:R:L:V:T:W:K:P:S:M:G:A:D | -7 | -0.07526881720430108 | 53 | neutral | pnca_p.val157gly | 7.18700589334483e-05 | 12.1451538387252 | 188179.926264401 | 0.919026337424192 | 119.468044436158 | 0.101660271548309 | 5.01153666069661e-06 | 9.70142977291842 | 0.986835744238421 | inf | 0.170978870202674 | 0.767057556984365 | 0.124324963210678 | inf | 0.763784339928386 | 0.382146811758261 | -2.35 | -0.6151832460732984 | Destabilising | GLY | 0 | pnca_complex.pdb | |
| 375 | V157L | V | 157 | L | A | PZA | 13.632 | -0.484 | Destabilising | -0.972 | Destabilising | -0.1250645994832041 | -0.2462006079027355 | V157 | VA157 | -2.04339 | -18.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.0 | 0.0 | -2.0 | 2.0 | 0.0 | 0.0 | 0.0 | 0.0 | -3.0 | 0.0 | 1.0 | -4.0 | -4.0 | 0.0 | -2.0 | -2.0 | -0.392868953318465 | Stabilising | 1.184 | Stabilising | 1.0 | 45 | 0.2586206896551724 | E | strand | 1.5 | 4.12 | VAL | 0.579 | 0.18557692307692306 | 3 | 3 | 0.225 | 0.842 | 4:2 | 144/150 | Q:F:E:I:R:L:V:T:W:K:P:S:M:G:A:D | -43 | -0.46236559139784944 | 72 | neutral | -0.57 | -0.1492146596858638 | Destabilising | LEU | 0 | pnca_complex.pdb | ||||||||||||||||||
| 376 | V157A | V | 157 | A | A | PZA | 13.632 | -1.625 | Destabilising | -0.931 | Destabilising | -0.4198966408268734 | -0.2358156028368794 | V157 | VA157 | 0.858959 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 3.0 | 0.0 | 3.0 | 0.0 | 2.0 | 0.0 | 0.0 | 5.0 | 0.03128515650609343 | Destabilising | -1.03 | Destabilising | -0.17561807331628304 | 45 | 0.2586206896551724 | E | strand | 1.5 | 4.12 | VAL | 0.579 | 0.18557692307692306 | 3 | 3 | 0.225 | 0.842 | 4:2 | 144/150 | Q:F:E:I:R:L:V:T:W:K:P:S:M:G:A:D | -36 | -0.3870967741935484 | 66 | neutral | pnca_p.val157ala | 7.18700589334483e-05 | 12.1451538387253 | 188179.926264427 | 0.919026337424197 | 119.468044436166 | 0.101660271548303 | 5.01153666068889e-06 | 9.70142977291842 | 0.986835744238421 | inf | 0.170978870202674 | 0.767057556984365 | 0.124324963210678 | inf | 0.763784339928386 | 0.382146811758261 | -1.74 | -0.4554973821989529 | Destabilising | ALA | 0 | pnca_complex.pdb | |
| 377 | L159P | L | 159 | P | A | PZA | 11.435 | -1.412 | Destabilising | -1.7519999999999998 | Destabilising | -0.3648578811369509 | -0.4437689969604863 | L159 | LA159 | 6.08412 | 24.0 | 4.0 | 0.0 | 0.0 | 4.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.0 | 2.0 | 2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.0 | 4.0 | -4.0 | 0.0 | -4.0 | 0.0 | -2.0 | -2.0 | 0.22159689391676807 | Destabilising | -4.496 | Destabilising | -0.7665814151747656 | 6 | 0.0298507462686567 | E | strand | -0.1333333333333334 | 5.42 | LEU | -0.599 | -0.49341021416803954 | 7 | 7 | -0.728 | -0.485 | 8:7 | 141/150 | G:A:M:H:F:Y:L:V | 92 | 0.968421052631579 | 95 | effect | -0.94 | -0.2460732984293193 | Destabilising | PRO | 0 | pnca_complex.pdb | ||||||||||||||||||
| 378 | L159R | L | 159 | R | A | PZA | 11.435 | -0.753 | Destabilising | -1.154 | Destabilising | -0.1945736434108527 | -0.2922998986828774 | L159 | LA159 | 0.0571381999999999 | -56.0 | -26.0 | 0.0 | -2.0 | -24.0 | 0.0 | 0.0 | 0.0 | 0.0 | -4.0 | 0.0 | -2.0 | -2.0 | 0.0 | 0.0 | 0.0 | 0.0 | -3.0 | 0.0 | 0.0 | -5.0 | -4.0 | 0.0 | -4.0 | 0.0 | 0.0020810976187180816 | Destabilising | -4.133 | Destabilising | -0.7046888320545609 | 6 | 0.0298507462686567 | E | strand | -0.1333333333333334 | 5.42 | LEU | -0.599 | -0.49341021416803954 | 7 | 7 | -0.728 | -0.485 | 8:7 | 141/150 | G:A:M:H:F:Y:L:V | 89 | 0.9368421052631579 | 91 | effect | pnca_p.leu159arg | 0.0005030904125341 | 14.1477154154513 | 1394038.39846606 | 0.908235680147999 | 122.741582019401 | 0.115264242017143 | 22.9578143501753 | 68.0817875210792 | 1.83303094984313 | inf | 4.24048522418865e-06 | 5.37258444573496 | 7.00237574052121 | inf | 28.35828361563 | 1.00814491180914e-07 | -0.41 | -0.1073298429319371 | Destabilising | ARG | 0 | pnca_complex.pdb | |
| 379 | L159V | L | 159 | V | A | PZA | 11.435 | -1.126 | Destabilising | -1.82 | Destabilising | -0.2909560723514211 | -0.4609929078014184 | L159 | LA159 | 2.84083 | 22.0 | 4.0 | 0.0 | 0.0 | 4.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -8.0 | 0.0 | -2.0 | -6.0 | 10.0 | 0.0 | -2.0 | 8.0 | 0.10346921233400592 | Destabilising | -2.332 | Destabilising | -0.39761295822676895 | 6 | 0.0298507462686567 | E | strand | -0.1333333333333334 | 5.42 | LEU | -0.599 | -0.49341021416803954 | 7 | 7 | -0.728 | -0.485 | 8:7 | 141/150 | G:A:M:H:F:Y:L:V | 60 | 0.631578947368421 | 80 | effect | pnca_p.leu159val | 0.0001437401178668 | 1.57903938912402 | 4.85029432717735 | 0.264247566376723 | 1.41439286276584 | 1.11640791656443 | 0.191756076673846 | 122.683760399179 | 4.85029436501262 | 0.685768096792206 | 4.84956447904112 | 0.312734154310187 | 0.504824686014995 | 0.061763864579114 | 379.558337204203 | 0.0881192621863332 | 0.766581879696361 | -1.09 | -0.2853403141361257 | Destabilising | VAL | 0 | pnca_complex.pdb |
| 380 | T160P | T | 160 | P | A | PZA | 9.847 | -0.79 | Destabilising | -2.375 | Destabilising | -0.2041343669250646 | -0.6015704154002026 | T160 | TA160 | 3.37194 | 6.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.0 | 0.0 | 2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -4.0 | 2.0 | -6.0 | 0.0 | 0.0 | 0.0 | 0.0 | -4.0 | 0.12281339461971605 | Destabilising | -3.753 | Destabilising | -0.6398976982097186 | 22 | 0.127906976744186 | E | strand | 1.633333333333333 | 4.98 | THR | -0.228 | -0.18780889621087316 | 6 | 6 | -0.411 | -0.147 | 7:6 | 141/150 | V:C:I:M:S:T | 91 | 0.9578947368421052 | 95 | effect | pnca_p.thr160pro | 0.0002156101768003 | 13.1460210124992 | 511969.848428359 | 0.907969111549571 | 113.719344731883 | 0.115600569485286 | 0.183926936278634 | 29.1287878787879 | 1.4643224129316 | inf | 0.0049931328456149 | 2.3016268790981 | 2.00455510251839 | inf | 9.2872640727157 | 0.0023075254069185 | -0.23 | -0.0602094240837696 | Destabilising | PRO | 0 | pnca_complex.pdb | |
| 381 | T160R | T | 160 | R | A | PZA | 9.847 | -0.456 | Destabilising | -2.007 | Destabilising | -0.117829457364341 | -0.5083586626139817 | T160 | TA160 | 2.8141 | -80.0 | -36.0 | 0.0 | -2.0 | -34.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -5.0 | 0.0 | -2.0 | -3.0 | -8.0 | 0.0 | -2.0 | -4.0 | 0.10249564754988016 | Destabilising | -2.869 | Destabilising | -0.48917306052855924 | 22 | 0.127906976744186 | E | strand | 1.633333333333333 | 4.98 | THR | -0.228 | -0.18780889621087316 | 6 | 6 | -0.411 | -0.147 | 7:6 | 141/150 | V:C:I:M:S:T | 83 | 0.8736842105263158 | 91 | effect | pnca_p.thr160arg | 0.0001437401178668 | 13.14560022562 | 511754.463552351 | 0.924803768446983 | 139.277183326532 | 0.0943844491369454 | 0.000162837134446 | 19.411022297013 | 1.28804840845689 | inf | 0.0292235860951597 | 1.53426649183163 | 0.91081598550184 | inf | 4.73122070382274 | 0.0296198560706035 | -0.29 | -0.0759162303664921 | Destabilising | ARG | 0 | pnca_complex.pdb | |
| 382 | T160A | T | 160 | A | A | PZA | 9.847 | -0.8420000000000001 | Destabilising | -2.509 | Destabilising | -0.2175710594315245 | -0.6355116514690983 | T160 | TA160 | 2.1045 | 8.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.0 | 0.0 | 2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.0 | 0.0 | 4.0 | 3.0 | 0.07665047093874518 | Destabilising | -1.519 | Destabilising | -0.2589940323955669 | 22 | 0.127906976744186 | E | strand | 1.633333333333333 | 4.98 | THR | -0.228 | -0.18780889621087316 | 6 | 6 | -0.411 | -0.147 | 7:6 | 141/150 | V:C:I:M:S:T | 57 | 0.6 | 75 | effect | pnca_p.thr160ala | 0.0005749604714675 | 14.1481370895081 | 1394626.35224664 | 0.901927875940744 | 114.814237034519 | 0.123226330243822 | 82.9586021395589 | 77.8405735976381 | 1.89120602753485 | inf | 7.2326389241213e-07 | 6.1407032156959 | 8.29603358299821 | inf | 33.1802749271012 | 8.399830460993881e-09 | -0.73 | -0.1910994764397905 | Destabilising | ALA | 0 | pnca_complex.pdb | |
| 383 | A161V | A | 161 | V | A | PZA | 7.033 | 0.043 | Stabilising | -0.846 | Destabilising | 0.0365646258503401 | -0.2142857142857142 | A161 | AA161 | -2.66025 | -2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -5.0 | 0.0 | -1.0 | -4.0 | -2.0 | 0.0 | -4.0 | -3.0 | -0.5114685072675537 | Stabilising | 0.125 | Stabilising | 0.10557432432432433 | 11 | 0.0852713178294573 | E | strand | 0.2333333333333333 | 4.53 | ALA | -0.773 | -0.6367380560131796 | 8 | 8 | -0.872 | -0.728 | 8:8 | 141/150 | E:Q:V:I:R:K:S:A | 21 | 0.22105263157894736 | 63 | effect | -0.2 | -0.0523560209424083 | Destabilising | VAL | 0 | pnca_complex.pdb | ||||||||||||||||||
| 384 | A161G | A | 161 | G | A | PZA | 7.033 | -0.745 | Destabilising | -0.925 | Destabilising | -0.1925064599483204 | -0.2342958459979736 | A161 | AA161 | 2.35053 | 10.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.0 | 0.0 | 11.0 | 10.0 | 0.08561141908084995 | Destabilising | -1.432 | Destabilising | -0.24416027280477406 | 11 | 0.0852713178294573 | E | strand | 0.2333333333333333 | 4.53 | ALA | -0.773 | -0.6367380560131796 | 8 | 8 | -0.872 | -0.728 | 8:8 | 141/150 | E:Q:V:I:R:K:S:A | 50 | 0.5263157894736842 | 75 | effect | -1.02 | -0.2670157068062827 | Destabilising | GLY | 0 | pnca_complex.pdb | ||||||||||||||||||
| 385 | G162S | G | 162 | S | A | PZA | 8.315 | -0.866 | Destabilising | 0.821 | Stabilising | -0.2237726098191214 | 0.3681614349775785 | G162 | GA162 | 0.905309 | -6.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -6.0 | 0.0 | -2.0 | -4.0 | 0.0 | 0.0 | -3.0 | -13.0 | 0.03297332439775931 | Destabilising | -1.14 | Destabilising | -0.19437340153452684 | 26 | 0.25 | - | loop | 1.8666666666666665 | 3.93 | GLY | -0.02 | -0.016474464579901153 | 5 | 5 | -0.244 | 0.083 | 6:5 | 141/150 | F:S:G:A:P | 21 | 0.22105263157894736 | 63 | effect | -0.55 | -0.143979057591623 | Destabilising | SER | 0 | pnca_complex.pdb | ||||||||||||||||||
| 386 | G162V | G | 162 | V | A | PZA | 8.315 | -0.386 | Destabilising | -0.162 | Destabilising | -0.0997416020671834 | -0.0410334346504559 | G162 | GA162 | 2.07181 | -6.0 | -2.0 | 0.0 | 0.0 | -2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 6.0 | 0.0 | 2.0 | 2.0 | 0.0 | 0.0 | 0.0 | 0.0 | -10.0 | 0.0 | -2.0 | -8.0 | 4.0 | 0.0 | 3.0 | -19.0 | 0.07545982998127901 | Destabilising | -1.467 | Destabilising | -0.2501278772378517 | 26 | 0.25 | - | loop | 1.8666666666666665 | 3.93 | GLY | -0.02 | -0.016474464579901153 | 5 | 5 | -0.244 | 0.083 | 6:5 | 141/150 | F:S:G:A:P | 66 | 0.6947368421052632 | 80 | effect | -1.39 | -0.3638743455497382 | Destabilising | VAL | 0 | pnca_complex.pdb | ||||||||||||||||||
| 387 | G162A | G | 162 | A | A | PZA | 8.315 | -0.551 | Destabilising | -0.1639999999999999 | Destabilising | -0.1423772609819121 | -0.0415400202634245 | G162 | GA162 | 0.560964 | -6.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -4.0 | 0.0 | -2.0 | -2.0 | 0.0 | 0.0 | -1.0 | -12.0 | 0.02043152994995593 | Destabilising | -1.074 | Destabilising | -0.18312020460358056 | 26 | 0.25 | - | loop | 1.8666666666666665 | 3.93 | GLY | -0.02 | -0.016474464579901153 | 5 | 5 | -0.244 | 0.083 | 6:5 | 141/150 | F:S:G:A:P | 10 | 0.10526315789473684 | 59 | effect | -0.09 | -0.0235602094240837 | Destabilising | ALA | 0 | pnca_complex.pdb | ||||||||||||||||||
| 388 | G162R | G | 162 | R | A | PZA | 8.315 | -0.44 | Destabilising | -0.04 | Destabilising | -0.1136950904392764 | -0.0101317122593718 | G162 | GA162 | 3.4246300000000005 | -68.0 | -22.0 | 0.0 | 0.0 | -22.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -7.0 | 0.0 | -3.0 | -5.0 | -2.0 | 0.0 | -5.0 | -17.0 | 0.12473247911188166 | Destabilising | -0.961 | Destabilising | -0.16385336743393009 | 26 | 0.25 | - | loop | 1.8666666666666665 | 3.93 | GLY | -0.02 | -0.016474464579901153 | 5 | 5 | -0.244 | 0.083 | 6:5 | 141/150 | F:S:G:A:P | 87 | 0.9157894736842105 | 91 | effect | -0.15 | -0.0392670157068062 | Destabilising | ARG | 0 | pnca_complex.pdb | ||||||||||||||||||
| 389 | G162D | G | 162 | D | A | PZA | 8.315 | -1.037 | Destabilising | 2.23 | Stabilising | -0.2679586563307493 | 1.0 | G162 | GA162 | 3.4317800000000003 | -20.0 | -24.0 | 0.0 | 0.0 | -24.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -6.0 | 0.0 | 0.0 | -4.0 | -4.0 | 0.0 | -5.0 | -19.0 | 0.12499289767553669 | Destabilising | -1.558 | Destabilising | -0.2656436487638534 | 26 | 0.25 | - | loop | 1.8666666666666665 | 3.93 | GLY | -0.02 | -0.016474464579901153 | 5 | 5 | -0.244 | 0.083 | 6:5 | 141/150 | F:S:G:A:P | 79 | 0.8315789473684211 | 85 | effect | pnca_p.gly162asp | 0.0002874802357337 | 14.146451459095 | 1392277.5078503 | 0.930573112990214 | 162.371849599053 | 0.0871237932808364 | 0.0113995443355929 | 38.8547368421053 | 1.58944397188817 | inf | 0.0008528275207519 | 3.06913879340442 | 3.20302487654751 | inf | 13.9909822352959 | 0.0001836895199759 | -0.94 | -0.2460732984293193 | Destabilising | ASP | 0 | pnca_complex.pdb | |
| 390 | V163A | V | 163 | A | A | PZA | 6.662999999999999 | -0.478 | Destabilising | 0.052 | Stabilising | -0.1235142118863049 | 0.0233183856502242 | V163 | VA163 | 0.471406 | 2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.0 | 0.0 | 6.0 | 1.0 | 0.01716963264592545 | Destabilising | -0.834 | Destabilising | -0.14219948849104858 | 87 | 0.5 | S | loop | 1.0 | 4.02 | VAL | -1.017 | -0.8377265238879735 | 9 | 9 | -1.094 | -0.993 | 9:9 | 141/150 | V:L:I:M | 65 | 0.6842105263157895 | 80 | effect | pnca_p.val163ala | 0.0002156101768003 | -9.98760797391822 | 4.5966027178937e-05 | 0.930014323968985 | 113.719344729607 | -0.087826816076596 | 127.94873509896 | 0.807902480033628 | -0.0926410587047397 | 0.0 | 1.0 | 0.0 | 0.0 | 11.7369754738005 | 0.000393645565148 | 0.984170607395186 | -0.36 | -0.094240837696335 | Destabilising | ALA | 0 | pnca_complex.pdb | |
| 391 | V163G | V | 163 | G | A | PZA | 6.662999999999999 | -0.815 | Destabilising | 0.031 | Stabilising | -0.210594315245478 | 0.0139013452914798 | V163 | VA163 | 1.14986 | 2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -1.0 | -1.0 | 2.0 | 6.0 | 0.0 | 11.0 | 13.0 | 0.04188040414047305 | Destabilising | -1.019 | Destabilising | -0.17374254049445864 | 87 | 0.5 | S | loop | 1.0 | 4.02 | VAL | -1.017 | -0.8377265238879735 | 9 | 9 | -1.094 | -0.993 | 9:9 | 141/150 | V:L:I:M | 75 | 0.7894736842105263 | 85 | effect | pnca_p.val163gly | 0.0001437401178668 | -9.98752126245061 | 4.59700131334254e-05 | 0.942832958100734 | 139.277183325398 | -0.0717096729269461 | 144471.706314857 | 1.2119588062211 | 0.0834878586628579 | 0.0 | 1.0 | 0.0 | 0.0 | 25.8386585962163 | 1.0105682238915901e-25 | 0.999999999999746 | -0.88 | -0.2303664921465968 | Destabilising | GLY | 0 | pnca_complex.pdb | |
| 392 | V163L | V | 163 | L | A | PZA | 6.662999999999999 | -0.098 | Destabilising | 0.072 | Stabilising | -0.0253229974160206 | 0.032286995515695 | V163 | VA163 | -0.813595 | -20.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -4.0 | 0.0 | 0.0 | -4.0 | -6.0 | 0.0 | 0.0 | -4.0 | -0.15642447896639236 | Stabilising | -0.458 | Destabilising | -0.07809036658141517 | 87 | 0.5 | S | loop | 1.0 | 4.02 | VAL | -1.017 | -0.8377265238879735 | 9 | 9 | -1.094 | -0.993 | 9:9 | 141/150 | V:L:I:M | 67 | 0.7052631578947368 | 80 | effect | pnca_p.val163leu | 7.18700589334483e-05 | -8.98740878149642 | 0.0001249735077034 | 0.940032862253634 | 119.468044435493 | -0.0752285585987741 | 4692673.5108124 | 2.42412778478352 | 0.384555509373631 | 0.0 | 1.0 | 0.0 | 0.0 | 188.544222231268 | 1.0341007080334399e-29 | 0.999999999999997 | -0.37 | -0.0968586387434555 | Destabilising | LEU | 0 | pnca_complex.pdb | |
| 393 | S164P | S | 164 | P | A | PZA | 10.588 | -0.304 | Destabilising | -0.348 | Destabilising | -0.0785529715762273 | -0.0881458966565349 | S164 | SA164 | 4.82419 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 4.0 | 0.0 | 4.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -4.0 | 2.0 | -2.0 | -6.0 | -2.0 | 0.0 | 0.0 | -2.0 | 0.1757075007830768 | Destabilising | -1.323 | Destabilising | -0.22557544757033246 | 46 | 0.2967741935483871 | - | loop | 1.7333333333333334 | 3.92 | SER | -0.033 | -0.027182866556836906 | 5 | 5 | -0.244 | 0.083 | 6:5 | 140/150 | N:V:Q:H:F:E:D:T:G:A:S | -23 | -0.24731182795698925 | 61 | neutral | pnca_p.ser164pro | 0.0004312203536006 | 14.1472939191292 | 1393450.9402227 | 0.915018435775013 | 132.576060676288 | 0.106710773023138 | 4.17896182047499 | 58.3312262958281 | 1.7659011066874 | inf | 2.48532104922106e-05 | 4.60461750194108 | 5.71767556863798 | inf | 23.547488635408 | 1.21868387173808e-06 | -0.03 | -0.0078534031413612 | Destabilising | PRO | 0 | pnca_complex.pdb | |
| 394 | T167I | T | 167 | I | A | PZA | 10.663 | 0.627 | Stabilising | -0.489 | Destabilising | 0.5331632653061225 | -0.1238601823708206 | T167 | TA167 | 0.429573 | -6.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.0 | 0.0 | 0.0 | 2.0 | 0.0 | 0.0 | 0.0 | 0.0 | -3.0 | 0.0 | 1.0 | -2.0 | 0.0 | 0.0 | 0.0 | -2.0 | 0.015645983726571434 | Destabilising | -0.058 | Destabilising | -0.009889173060528559 | 57 | 0.3313953488372093 | H | helix | -1.6333333333333335 | 4.06 | THR | 0.303 | 0.0971153846153846 | 4 | 4 | -0.038 | 0.389 | 5:4 | 129/150 | L:N:R:E:Q:D:G:A:S:T:P | 19 | 0.2 | 59 | effect | pnca_p.thr167ile | 0.0001437401178668 | 1.57903938912402 | 4.85029432717736 | 0.264247566376722 | 1.41439286276584 | 1.11640791656443 | 0.191756076673841 | 122.683760399237 | 4.85029436501262 | 0.685768096792206 | 4.84956447904112 | 0.312734154310187 | 0.504824686014995 | 0.061763864579114 | 379.558337204203 | 0.0881192621863332 | 0.766581879696361 | -0.04 | -0.0104712041884816 | Destabilising | ILE | 0 | pnca_complex.pdb |
| 395 | T168N | T | 168 | N | A | PZA | 10.468 | -0.505 | Destabilising | -0.341 | Destabilising | -0.1304909560723514 | -0.0863728470111449 | T168 | TA168 | 0.148032 | -10.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -1.0 | 0.0 | 1.0 | -2.0 | -2.0 | 0.0 | 0.0 | 2.0 | 0.005391647666431136 | Destabilising | -1.149 | Destabilising | -0.1959079283887468 | 24 | 0.1395348837209302 | H | helix | 0.9333333333333332 | 4.77 | THR | 0.703 | 0.2253205128205128 | 2 | 2 | 0.389 | 0.842 | 4:2 | 124/150 | L:N:V:C:R:Y:H:F:W:G:S:A:T:P | 3 | 0.031578947368421054 | 53 | effect | -0.45 | -0.1178010471204188 | Destabilising | ASN | 0 | pnca_complex.pdb | ||||||||||||||||||
| 396 | T168I | T | 168 | I | A | PZA | 10.468 | 0.963 | Stabilising | -1.2009999999999998 | Destabilising | 0.8188775510204082 | -0.3042046605876393 | T168 | TA168 | -0.7812 | -12.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.0 | 0.0 | 0.0 | 2.0 | 0.0 | 0.0 | 0.0 | 0.0 | -3.0 | 0.0 | -3.0 | -2.0 | 0.0 | 0.0 | 0.0 | 0.0 | -0.1501961085903253 | Stabilising | -0.018 | Destabilising | -0.0030690537084398974 | 24 | 0.1395348837209302 | H | helix | 0.9333333333333332 | 4.77 | THR | 0.703 | 0.2253205128205128 | 2 | 2 | 0.389 | 0.842 | 4:2 | 124/150 | L:N:V:C:R:Y:H:F:W:G:S:A:T:P | 11 | 0.11578947368421053 | 59 | effect | pnca_p.thr168ile | 0.0002874802357337 | -10.9877041754913 | 1.69083297052993e-05 | 0.946048325624975 | 162.371849597271 | -0.0676700068561389 | 2065.08997177458 | 0.605874316939891 | -0.217617456890647 | 0.0 | 1.0 | 0.0 | 0.0 | 7.34660540805975 | 0.0596751347828363 | 0.807010141806273 | 0.69 | 0.3876404494382022 | Stabilising | ILE | 0 | pnca_complex.pdb | |
| 397 | T168S | T | 168 | S | A | PZA | 10.468 | -0.382 | Destabilising | -0.83 | Destabilising | -0.0987080103359173 | -0.2102330293819655 | T168 | TA168 | 0.4742399999999999 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.0 | 0.0 | 2.0 | 0.0 | 2.0 | 0.0 | 2.0 | 4.0 | 0.017272853094792352 | Destabilising | -0.28 | Destabilising | -0.047740835464620636 | 24 | 0.1395348837209302 | H | helix | 0.9333333333333332 | 4.77 | THR | 0.703 | 0.2253205128205128 | 2 | 2 | 0.389 | 0.842 | 4:2 | 124/150 | L:N:V:C:R:Y:H:F:W:G:S:A:T:P | -71 | -0.7634408602150538 | 87 | neutral | pnca_p.thr168ser | 0.0002874802357337 | 0.480257130287145 | 1.61648999729673 | 0.677247786834332 | 1.1538493489906 | 0.416221693678882 | 0.0799389646162879 | 12.6318165284439 | 1.61648444070648 | 0.208571528713835 | 1.61641362774286 | 0.527693668101443 | 0.277618116975238 | 0.0307788891197694 | 20.1401594005 | 5.751485287704321e-25 | 0.999999999999395 | 0.09 | 0.0505617977528089 | Stabilising | SER | 0 | pnca_complex.pdb |
| 398 | T168P | T | 168 | P | A | PZA | 10.468 | 0.151 | Stabilising | -1.31 | Destabilising | 0.1284013605442177 | -0.3318135764944275 | T168 | TA168 | 3.22365 | 0.0 | -2.0 | 0.0 | 0.0 | -2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 4.0 | 2.0 | 0.0 | 2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 4.0 | 0.0 | -4.0 | 2.0 | 0.0 | 2.0 | -2.0 | 0.1174123500316873 | Destabilising | -1.21 | Destabilising | -0.206308610400682 | 24 | 0.1395348837209302 | H | helix | 0.9333333333333332 | 4.77 | THR | 0.703 | 0.2253205128205128 | 2 | 2 | 0.389 | 0.842 | 4:2 | 124/150 | L:N:V:C:R:Y:H:F:W:G:S:A:T:P | 49 | 0.5157894736842106 | 71 | effect | 0.61 | 0.3426966292134831 | Stabilising | PRO | 0 | pnca_complex.pdb | ||||||||||||||||||
| 399 | A171T | A | 171 | T | A | PZA | 10.476 | -1.816 | Destabilising | 0.043 | Stabilising | -0.4692506459948319 | 0.0192825112107623 | A171 | AA171 | 0.486585 | -2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -3.0 | 0.0 | -1.0 | -2.0 | 0.0 | 0.0 | 0.0 | -5.0 | 0.017722484866585567 | Destabilising | -1.914 | Destabilising | -0.32634271099744244 | 5 | 0.0387596899224806 | H | helix | 2.4666666666666663 | 5.33 | ALA | -0.872 | -0.7182866556836903 | 8 | 8 | -0.993 | -0.827 | 9:8 | 122/150 | R:C:V:T:E:A | 25 | 0.2631578947368421 | 63 | effect | pnca_p.ala171thr | 0.0003593502946672 | -10.9877909019996 | 1.69068633684891e-05 | 0.93969121942854 | 145.229797681913 | -0.075657964669657 | 60.3389082676185 | 0.484657419083649 | -0.314565134742567 | 0.0 | 0.596111875058711 | 0.224672226566594 | 0.0 | 5.29224350433385 | 0.177777263899814 | 0.673290424524484 | -1.47 | -0.3848167539267015 | Destabilising | THR | 0 | pnca_complex.pdb | |
| 400 | A171V | A | 171 | V | A | PZA | 10.476 | -0.659 | Destabilising | -1.298 | Destabilising | -0.1702842377260982 | -0.328774062816616 | A171 | AA171 | 0.499158 | -2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -7.0 | 0.0 | -5.0 | -6.0 | 2.0 | 0.0 | 2.0 | -1.0 | 0.018180420894674348 | Destabilising | -1.528 | Destabilising | -0.26052855924978685 | 5 | 0.0387596899224806 | H | helix | 2.4666666666666663 | 5.33 | ALA | -0.872 | -0.7182866556836903 | 8 | 8 | -0.993 | -0.827 | 9:8 | 122/150 | R:C:V:T:E:A | 38 | 0.4 | 66 | effect | pnca_p.ala171val | 0.0001437401178668 | 1.57903938912402 | 4.85029432717736 | 0.264247566376722 | 1.41439286276584 | 1.11640791656443 | 0.191756076673654 | 122.683760399096 | 4.85029436501262 | 0.685768096792206 | 4.84956447904112 | 0.312734154310187 | 0.504824686014995 | 0.061763864579114 | 379.558337204203 | 0.0881192621863332 | 0.766581879696361 | -0.62 | -0.1623036649214659 | Destabilising | VAL | 0 | pnca_complex.pdb |
| 401 | A171E | A | 171 | E | A | PZA | 10.476 | -2.6710000000000003 | Destabilising | 1.116 | Stabilising | -0.6901808785529716 | 0.5004484304932735 | A171 | AA171 | 3.52921 | -36.0 | -26.0 | 0.0 | 0.0 | -26.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -1.0 | 0.0 | -3.0 | -3.0 | 0.0 | 0.0 | 0.0 | -5.0 | 0.12854151035482483 | Destabilising | -3.951 | Destabilising | -0.6736572890025575 | 5 | 0.0387596899224806 | H | helix | 2.4666666666666663 | 5.33 | ALA | -0.872 | -0.7182866556836903 | 8 | 8 | -0.993 | -0.827 | 9:8 | 122/150 | R:C:V:T:E:A | 75 | 0.7894736842105263 | 85 | effect | pnca_p.ala171glu | 0.0001437401178668 | -9.98752126245058 | 4.59700131334266e-05 | 0.942832958100734 | 139.277183325398 | -0.0717096729269461 | 144471.706314849 | 1.2119588062211 | 0.0834878586628579 | 0.0 | 1.0 | 0.0 | 0.0 | 25.8386585962163 | 1.0105682238915901e-25 | 0.999999999999746 | -0.69 | -0.1806282722513089 | Destabilising | GLU | 0 | pnca_complex.pdb | |
| 402 | A171P | A | 171 | P | A | PZA | 10.476 | -1.241 | Destabilising | -1.239 | Destabilising | -0.3206718346253229 | -0.3138297872340426 | A171 | AA171 | 4.26761 | -2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 4.0 | 2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -3.0 | 4.0 | -5.0 | -4.0 | 4.0 | 0.0 | 2.0 | 1.0 | 0.155435645655927 | Destabilising | -3.012 | Destabilising | -0.5135549872122762 | 5 | 0.0387596899224806 | H | helix | 2.4666666666666663 | 5.33 | ALA | -0.872 | -0.7182866556836903 | 8 | 8 | -0.993 | -0.827 | 9:8 | 122/150 | R:C:V:T:E:A | 80 | 0.8421052631578947 | 91 | effect | -0.05 | -0.013089005235602 | Destabilising | PRO | 0 | pnca_complex.pdb | ||||||||||||||||||
| 403 | L172P | L | 172 | P | A | PZA | 13.187 | -1.821 | Destabilising | -1.3530000000000002 | Destabilising | -0.4705426356589147 | -0.3427051671732523 | L172 | LA172 | 4.7117 | 14.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.0 | 2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 3.0 | 4.0 | 1.0 | -1.0 | 2.0 | 0.0 | -2.0 | 4.0 | 0.17161037012216 | Destabilising | -2.793 | Destabilising | -0.4762148337595908 | 51 | 0.2537313432835821 | H | helix | 0.6999999999999998 | 4.4 | LEU | 1.192 | 0.382051282051282 | 1 | 1 | 0.59 | 1.183 | 3:1 | 122/150 | H:F:E:L:V:K:R:C:I:T:A:M:D:W | 79 | 0.8315789473684211 | 85 | effect | pnca_p.leu172pro | 0.0007187005893344 | 3.77963380040362 | 43.7999992563294 | 0.000336884092116 | 1.0542469487651 | 3.58515033392406 | 8.22614212186537 | 807.950983717549 | 43.8 | 1.6414741105041 | 43.791882510185 | 1.04401171857701e-06 | 5.98129462653992 | 6.06119169154248 | 1899.94618136838 | 32.5514826715601 | 1.16076545932747e-08 | -1.44 | -0.3769633507853403 | Destabilising | PRO | 0 | pnca_complex.pdb |
| 404 | L172R | L | 172 | R | A | PZA | 13.187 | -0.848 | Destabilising | -0.7040000000000001 | Destabilising | -0.2191214470284237 | -0.1783181357649443 | L172 | LA172 | -0.385063 | -32.0 | -36.0 | 0.0 | -2.0 | -34.0 | 0.0 | 0.0 | 0.0 | 0.0 | -2.0 | 0.0 | 0.0 | -4.0 | 0.0 | 0.0 | 0.0 | 0.0 | -8.0 | 0.0 | -1.0 | -6.0 | -8.0 | 0.0 | -8.0 | 0.0 | -0.07403349227101438 | Stabilising | -1.797 | Destabilising | -0.3063938618925831 | 51 | 0.2537313432835821 | H | helix | 0.6999999999999998 | 4.4 | LEU | 1.192 | 0.382051282051282 | 1 | 1 | 0.59 | 1.183 | 3:1 | 122/150 | H:F:E:L:V:K:R:C:I:T:A:M:D:W | 33 | 0.3473684210526316 | 66 | effect | pnca_p.leu172arg | 0.0001437401178668 | 13.1456002256205 | 511754.463552565 | 0.924803768446996 | 139.277183326561 | 0.0943844491369283 | 0.0001628371344453 | 19.411022297013 | 1.28804840845689 | inf | 0.0292235860951597 | 1.53426649183163 | 0.91081598550184 | inf | 4.73122070382274 | 0.0296198560706035 | -0.43 | -0.112565445026178 | Destabilising | ARG | 0 | pnca_complex.pdb | |
| 405 | E173G | E | 173 | G | A | PZA | 15.936 | -1.172 | Destabilising | -0.78 | Destabilising | -0.3028423772609819 | -0.1975683890577507 | E173 | EA173 | 0.769667 | 6.0 | 18.0 | 0.0 | 0.0 | 18.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 3.0 | 0.0 | 3.0 | 1.0 | 0.0 | 0.0 | 3.0 | 13.0 | 0.028032947501074455 | Destabilising | -0.869 | Destabilising | -0.14816709292412616 | 114 | 0.5112107623318386 | H | helix | -1.0666666666666669 | 3.82 | GLU | 1.516 | 0.4858974358974359 | 1 | 1 | 0.842 | 1.712 | 2:1 | 122/150 | Q:E:F:H:K:R:L:V:S:M:G:A:T:D | -5 | -0.053763440860215055 | 53 | neutral | -1.04 | -0.2722513089005235 | Destabilising | GLY | 0 | pnca_complex.pdb | ||||||||||||||||||
| 406 | E174D | E | 174 | D | A | PZA | 14.835 | -0.698 | Destabilising | -0.016 | Destabilising | -0.1803617571059431 | -0.0040526849037487 | E174 | EA174 | 0.557649 | 14.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.0 | 0.0 | 2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0203107904340795 | Destabilising | -0.445 | Destabilising | -0.07587382779198636 | 104 | 0.4663677130044843 | H | helix | -1.7 | 3.93 | GLU | -0.292 | -0.24052718286655683 | 6 | 6 | -0.485 | -0.147 | 7:6 | 122/150 | D:T:A:G:S:K:R:Q:E | -14 | -0.15053763440860216 | 57 | neutral | pnca_p.glu174asp | 7.18700589334483e-05 | 12.1451538387268 | 188179.926264691 | 0.919026337424243 | 119.468044436249 | 0.101660271548244 | 5.01153666061119e-06 | 9.70142977291842 | 0.986835744238421 | inf | 0.170978870202674 | 0.767057556984365 | 0.124324963210678 | inf | 0.763784339928386 | 0.382146811758261 | -0.43 | -0.112565445026178 | Destabilising | ASP | 0 | pnca_complex.pdb | |
| 407 | E174G | E | 174 | G | A | PZA | 14.835 | -0.868 | Destabilising | -1.181 | Destabilising | -0.2242894056847545 | -0.2991388044579534 | E174 | EA174 | 0.8340420000000001 | 22.0 | 22.0 | 0.0 | 0.0 | 22.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.0 | 0.0 | 2.0 | 0.0 | 0.0 | 0.0 | 3.0 | 15.0 | 0.030377625128388177 | Destabilising | -0.968 | Destabilising | -0.1650468883205456 | 104 | 0.4663677130044843 | H | helix | -1.7 | 3.93 | GLU | -0.292 | -0.24052718286655683 | 6 | 6 | -0.485 | -0.147 | 7:6 | 122/150 | D:T:A:G:S:K:R:Q:E | 54 | 0.5684210526315789 | 75 | effect | pnca_p.glu174gly | 0.0001437401178668 | -9.98752126245053 | 4.59700131334288e-05 | 0.942832958100734 | 139.277183325396 | -0.0717096729269466 | 144471.706314838 | 1.2119588062211 | 0.0834878586628579 | 0.0 | 1.0 | 0.0 | 0.0 | 25.8386585962163 | 1.0105682238915901e-25 | 0.999999999999746 | -0.01 | -0.0026178010471204 | Destabilising | GLY | 0 | pnca_complex.pdb | |
| 408 | E174K | E | 174 | K | A | PZA | 14.835 | 0.204 | Stabilising | -0.8190000000000001 | Destabilising | 0.173469387755102 | -0.2074468085106383 | E174 | EA174 | -0.813418 | -6.0 | 4.0 | 0.0 | 0.0 | 4.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.0 | -2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -1.0 | 0.0 | 0.0 | 0.0 | 0.0 | -0.1563904483580712 | Stabilising | -0.452 | Destabilising | -0.07706734867860188 | 104 | 0.4663677130044843 | H | helix | -1.7 | 3.93 | GLU | -0.292 | -0.24052718286655683 | 6 | 6 | -0.485 | -0.147 | 7:6 | 122/150 | D:T:A:G:S:K:R:Q:E | 26 | 0.2736842105263158 | 63 | effect | -0.16 | -0.0418848167539267 | Destabilising | LYS | 0 | pnca_complex.pdb | ||||||||||||||||||
| 409 | M175K | M | 175 | K | A | PZA | 11.015999999999998 | -1.311 | Destabilising | -0.207 | Destabilising | -0.3387596899224806 | -0.0524316109422492 | M175 | MA175 | 2.59826 | -16.0 | -36.0 | 0.0 | 0.0 | -36.0 | 0.0 | 0.0 | 0.0 | 0.0 | -2.0 | 0.0 | -2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -5.0 | 0.0 | -4.0 | -1.0 | -2.0 | 0.0 | 2.0 | -2.0 | 0.09463428492340416 | Destabilising | -4.252 | Destabilising | -0.7249786871270246 | 0 | 0.0 | H | helix | -2.033333333333333 | 6.81 | MET | -0.521 | -0.4291598023064251 | 7 | 7 | -0.674 | -0.411 | 7:7 | 120/150 | F:M:I:W:C:L:V | 78 | 0.8210526315789474 | 85 | effect | pnca_p.met175lys | 7.18700589334483e-05 | 12.1451538387265 | 188179.926264637 | 0.919026337424235 | 119.468044436234 | 0.101660271548255 | 5.01153666062558e-06 | 9.70142977291842 | 0.986835744238421 | inf | 0.170978870202674 | 0.767057556984365 | 0.124324963210678 | inf | 0.763784339928386 | 0.382146811758261 | -0.95 | -0.2486910994764398 | Destabilising | LYS | 0 | pnca_complex.pdb | |
| 410 | M175R | M | 175 | R | A | PZA | 11.015999999999998 | -1.175 | Destabilising | -0.698 | Destabilising | -0.3036175710594315 | -0.1767983789260385 | M175 | MA175 | 2.37207 | -36.0 | -40.0 | 0.0 | -2.0 | -38.0 | 0.0 | 0.0 | 0.0 | 0.0 | -2.0 | 0.0 | -2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -9.0 | 0.0 | -4.0 | -5.0 | -4.0 | 0.0 | -6.0 | 0.0 | 0.0863959527677212 | Destabilising | -3.407 | Destabilising | -0.5809036658141518 | 0 | 0.0 | H | helix | -2.033333333333333 | 6.81 | MET | -0.521 | -0.4291598023064251 | 7 | 7 | -0.674 | -0.411 | 7:7 | 120/150 | F:M:I:W:C:L:V | 74 | 0.7789473684210526 | 85 | effect | pnca_p.met175arg | 7.18700589334483e-05 | 12.1451538387266 | 188179.92626466 | 0.919026337424239 | 119.46804443624 | 0.10166027154825 | 5.01153666061918e-06 | 9.70142977291842 | 0.986835744238421 | inf | 0.170978870202674 | 0.767057556984365 | 0.124324963210678 | inf | 0.763784339928386 | 0.382146811758261 | -0.8 | -0.2094240837696335 | Destabilising | ARG | 0 | pnca_complex.pdb | |
| 411 | M175T | M | 175 | T | A | PZA | 11.015999999999998 | -2.131 | Destabilising | 0.1159999999999999 | Stabilising | -0.5506459948320412 | 0.0520179372197309 | M175 | MA175 | 2.83612 | 24.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -2.0 | 0.0 | -2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -4.0 | 0.0 | -4.0 | 0.0 | 10.0 | 0.0 | 10.0 | 8.0 | 0.10329766388158422 | Destabilising | -3.057 | Destabilising | -0.521227621483376 | 0 | 0.0 | H | helix | -2.033333333333333 | 6.81 | MET | -0.521 | -0.4291598023064251 | 7 | 7 | -0.674 | -0.411 | 7:7 | 120/150 | F:M:I:W:C:L:V | 72 | 0.7578947368421053 | 85 | effect | pnca_p.met175thr | 0.0002156101768003 | 13.1460210124993 | 511969.848428383 | 0.907969111549572 | 113.719344731884 | 0.115600569485285 | 0.183926936278602 | 29.1287878787879 | 1.4643224129316 | inf | 0.0049931328456149 | 2.3016268790981 | 2.00455510251839 | inf | 9.2872640727157 | 0.0023075254069185 | -1.73 | -0.4528795811518324 | Destabilising | THR | 0 | pnca_complex.pdb | |
| 412 | M175I | M | 175 | I | A | PZA | 11.015999999999998 | -0.6759999999999999 | Destabilising | -1.143 | Destabilising | -0.1746770025839793 | -0.2895136778115502 | M175 | MA175 | 1.6779700000000002 | 14.0 | 2.0 | 0.0 | 0.0 | 2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -5.0 | 0.0 | -1.0 | -4.0 | 6.0 | 0.0 | 4.0 | 4.0 | 0.06111531989597827 | Destabilising | -1.272 | Destabilising | -0.21687979539641944 | 0 | 0.0 | H | helix | -2.033333333333333 | 6.81 | MET | -0.521 | -0.4291598023064251 | 7 | 7 | -0.674 | -0.411 | 7:7 | 120/150 | F:M:I:W:C:L:V | 19 | 0.2 | 59 | effect | pnca_p.met175ile | 0.0002874802357337 | 0.480257130287143 | 1.61648999729673 | 0.677247786834333 | 1.1538493489906 | 0.416221693678881 | 0.0799389646162787 | 12.6318165284426 | 1.61648444070648 | 0.208571528713835 | 1.61641362774286 | 0.527693668101443 | 0.277618116975238 | 0.0307788891197694 | 20.1401594005 | 5.751485287704321e-25 | 0.999999999999395 | -0.65 | -0.1701570680628272 | Destabilising | ILE | 0 | pnca_complex.pdb |
| 413 | M175V | M | 175 | V | A | PZA | 11.015999999999998 | -1.251 | Destabilising | -1.081 | Destabilising | -0.3232558139534883 | -0.2738095238095238 | M175 | MA175 | 2.7460000000000004 | 24.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -2.0 | 0.0 | -4.0 | 0.0 | 8.0 | 0.0 | 8.0 | 8.0 | 0.1000152973142287 | Destabilising | -2.087 | Destabilising | -0.35583972719522594 | 0 | 0.0 | H | helix | -2.033333333333333 | 6.81 | MET | -0.521 | -0.4291598023064251 | 7 | 7 | -0.674 | -0.411 | 7:7 | 120/150 | F:M:I:W:C:L:V | 52 | 0.5473684210526316 | 75 | effect | pnca_p.met175val | 0.0007187005893344 | 2.42868773335338 | 11.3439859738742 | 0.0004314327258942 | 0.689954362035746 | 3.52007011911253 | 3.15129211999938 | 52.6672541515188 | 11.3440134907251 | 1.05476673431854 | 11.3408060961982 | 0.000313793551117 | 3.50335598599778 | 2.58674701617199 | 67.9086927550226 | 16.1999449415698 | 5.69957727561539e-05 | -1.13 | -0.2958115183246073 | Destabilising | VAL | 0 | pnca_complex.pdb |
| 414 | R176C | R | 176 | C | A | PZA | 17.132 | -0.417 | Destabilising | -0.8809999999999999 | Destabilising | -0.1077519379844961 | -0.2231509625126646 | R176 | RA176 | 1.53676 | 32.0 | 22.0 | 0.0 | 0.0 | 22.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -3.0 | 3.0 | 2.0 | 0.0 | 2.0 | 4.0 | 0.05597214431923309 | Destabilising | -0.701 | Destabilising | -0.11952259164535378 | 188 | 0.6861313868613139 | H | helix | -1.1 | 3.67 | ARG | 1.185 | 0.3798076923076923 | 1 | 1 | 0.59 | 1.183 | 3:1 | 116/150 | S:M:A:G:T:D:E:Q:N:L:V:K:I:R | 55 | 0.5789473684210527 | 75 | effect | 0.75 | 0.4213483146067415 | Stabilising | CYS | 0 | pnca_complex.pdb | ||||||||||||||||||
| 415 | T177P | T | 177 | P | A | PZA | 19.207 | -0.045 | Destabilising | -0.36 | Destabilising | -0.0116279069767441 | -0.0911854103343465 | T177 | TA177 | 0.790967 | 0.0 | 13.0 | 0.0 | -2.0 | 15.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.0 | 2.0 | 2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 4.0 | 4.0 | -1.0 | 0.0 | -2.0 | 0.0 | -4.0 | -2.0 | 0.02880873986552932 | Destabilising | -0.444 | Destabilising | -0.07570332480818415 | 126 | 0.7325581395348837 | H | helix | -1.1333333333333335 | 3.45 | THR | 1.87 | 0.5993589743589743 | 1 | 1 | 1.183 | 1.712 | 1:1 | 114/150 | N:L:R:K:H:E:Q:D:T:S:M:G:A | 21 | 0.22105263157894736 | 63 | effect | pnca_p.thr177pro | 0.0002874802357337 | 1.57937329521209 | 4.85191414039982 | 0.114342297004304 | 1.0002536454007 | 1.57897279602454 | 0.581889091312676 | 40.456291107532 | 4.85191417753471 | 0.685913110299906 | 4.85118443551178 | 0.137954936368295 | 0.860262754777729 | 0.351471331417763 | 67.0421060419706 | 1.17497090855698 | 0.278382201819561 | -0.19 | -0.0497382198952879 | Destabilising | PRO | 0 | pnca_complex.pdb |
| 416 | A178P | A | 178 | P | A | PZA | 17.128 | -0.485 | Destabilising | -0.05 | Destabilising | -0.1253229974160206 | -0.0126646403242147 | A178 | AA178 | 2.01949 | 0.0 | -2.0 | 0.0 | 0.0 | -2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.0 | 2.0 | 2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -6.0 | 2.0 | -8.0 | -2.0 | 0.0 | 0.0 | -2.0 | -5.0 | 0.07355422169450535 | Destabilising | -1.803 | Destabilising | -0.3074168797953964 | 32 | 0.2480620155038759 | T | loop | 0.1 | 3.71 | ALA | -0.496 | -0.4085667215815486 | 7 | 7 | -0.674 | -0.411 | 7:7 | 110/150 | G:M:A:S:C:K:V:Q:H:E | 60 | 0.631578947368421 | 80 | effect | -0.09 | -0.0235602094240837 | Destabilising | PRO | 0 | pnca_complex.pdb | ||||||||||||||||||
| 417 | S179I | S | 179 | I | A | PZA | 19.449 | 0.381 | Stabilising | -0.451 | Destabilising | 0.3239795918367347 | -0.1142350557244174 | S179 | SA179 | 1.25588 | -8.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.0 | 0.0 | 2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.0 | 0.045741883317914615 | Destabilising | 0.395 | Stabilising | 0.3336148648648649 | 87 | 0.5612903225806452 | T | loop | 1.7333333333333334 | 3.5 | SER | -0.876 | -0.7215815485996705 | 8 | 8 | -1.028 | -0.779 | 9:8 | 107/150 | W:R:D:Q:S:G | 35 | 0.3684210526315789 | 66 | effect | pnca_p.ser179ile | 7.18700589334483e-05 | -8.98740878149641 | 0.0001249735077034 | 0.940032862253634 | 119.468044435492 | -0.0752285585987746 | 4692673.510814 | 2.42412778478352 | 0.384555509373631 | 0.0 | 1.0 | 0.0 | 0.0 | 188.544222231268 | 1.0341007080334399e-29 | 0.999999999999997 | -0.66 | -0.1727748691099476 | Destabilising | ILE | 0 | pnca_complex.pdb | |
| 418 | V180A | V | 180 | A | A | PZA | 15.436 | -2.048 | Destabilising | -1.661 | Destabilising | -0.5291989664082687 | -0.4207193515704154 | V180 | VA180 | 2.8049 | 2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -2.0 | 0.0 | -4.0 | 0.0 | 2.0 | 0.0 | 2.0 | 5.0 | 0.10216056352391845 | Destabilising | -2.408 | Destabilising | -0.4105711849957374 | 6 | 0.0344827586206896 | - | loop | -0.0333333333333332 | 5.26 | VAL | -0.509 | -0.41927512355848434 | 7 | 7 | -0.674 | -0.411 | 7:7 | 102/150 | I:L:V:S:A:G | -8 | -0.08602150537634409 | 53 | neutral | pnca_p.val180ala | 0.0001437401178668 | 13.14560022562 | 511754.463552312 | 0.92480376844698 | 139.277183326525 | 0.094384449136949 | 0.0001628371344461 | 19.411022297013 | 1.28804840845689 | inf | 0.0292235860951597 | 1.53426649183163 | 0.91081598550184 | inf | 4.73122070382274 | 0.0296198560706035 | -1.98 | -0.518324607329843 | Destabilising | ALA | 0 | pnca_complex.pdb | |
| 419 | V180G | V | 180 | G | A | PZA | 15.436 | -2.785 | Destabilising | -1.577 | Destabilising | -0.7196382428940569 | -0.3994427558257345 | V180 | VA180 | 4.93179 | 12.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -4.0 | 0.0 | -6.0 | 0.0 | 6.0 | 0.0 | 13.0 | 23.0 | 0.17962652699975962 | Destabilising | -3.447 | Destabilising | -0.5877237851662404 | 6 | 0.0344827586206896 | - | loop | -0.0333333333333332 | 5.26 | VAL | -0.509 | -0.41927512355848434 | 7 | 7 | -0.674 | -0.411 | 7:7 | 102/150 | I:L:V:S:A:G | 61 | 0.6421052631578947 | 80 | effect | pnca_p.val180gly | 0.0007905706482679 | 15.1494066679809 | 3795803.48339175 | 0.92523341791644 | 161.432542879438 | 0.0938435732830823 | 24.1993753459118 | 107.166385135135 | 2.03005858162844 | inf | 3.5812015819156903e-09 | 8.44597123233921 | 12.2081619622864 | inf | 47.6847963834956 | 5.0055851012886495e-12 | -2.32 | -0.6073298429319371 | Destabilising | GLY | 0 | pnca_complex.pdb | |
| 420 | V180F | V | 180 | F | A | PZA | 15.436 | -1.808 | Destabilising | -1.073 | Destabilising | -0.4671834625322997 | -0.2717831813576494 | V180 | VA180 | 10.5926 | -22.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -10.0 | 0.0 | -6.0 | -8.0 | -12.0 | 0.0 | -12.0 | -4.0 | 0.3858055492828473 | Destabilising | -3.033 | Destabilising | -0.5171355498721227 | 6 | 0.0344827586206896 | - | loop | -0.0333333333333332 | 5.26 | VAL | -0.509 | -0.41927512355848434 | 7 | 7 | -0.674 | -0.411 | 7:7 | 102/150 | I:L:V:S:A:G | 57 | 0.6 | 75 | effect | pnca_p.val180phe | 0.0005749604714675 | 2.6796663501904 | 14.5802277940117 | 0.0010245352377103 | 0.816050632122415 | 3.28370108999367 | 3.35697961122208 | 99.5538692592325 | 14.5802781289507 | 1.16376580853041 | 14.5801759034061 | 0.0005075351447614 | 3.29453387923245 | 2.60435121163486 | 147.676327006136 | 15.0663448164144 | 0.0001037975122989 | -1.23 | -0.3219895287958115 | Destabilising | PHE | 0 | pnca_complex.pdb |
| 421 | V180L | V | 180 | L | A | PZA | 15.436 | -0.877 | Destabilising | -1.664 | Destabilising | -0.2266149870801033 | -0.4214792299898683 | V180 | VA180 | -0.0108685 | -16.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -9.0 | 0.0 | -2.0 | -9.0 | -10.0 | 0.0 | -10.0 | -2.0 | -0.0020896139352457126 | Stabilising | -2.269 | Destabilising | -0.38687127024722934 | 6 | 0.0344827586206896 | - | loop | -0.0333333333333332 | 5.26 | VAL | -0.509 | -0.41927512355848434 | 7 | 7 | -0.674 | -0.411 | 7:7 | 102/150 | I:L:V:S:A:G | 56 | 0.5894736842105263 | 75 | effect | -0.8 | -0.2094240837696335 | Destabilising | LEU | 0 | pnca_complex.pdb | ||||||||||||||||||
| 422 | L182W | L | 182 | W | A | PZA | 15.184 | -1.318 | Destabilising | -0.228 | Destabilising | -0.3405684754521964 | -0.0577507598784194 | L182 | LA182 | 4.86413 | -20.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -1.0 | 0.0 | -1.0 | 0.0 | 4.0 | 0.0 | 4.0 | 2.0 | 0.17716220252187154 | Destabilising | -1.198 | Destabilising | -0.2042625745950554 | 50 | 0.2487562189054726 | E | strand | 1.5 | 4.17 | LEU | 0.281 | 0.09006410256410256 | 4 | 4 | -0.038 | 0.389 | 5:4 | 87/150 | F:Q:L:V:R:I | 75 | 0.7894736842105263 | 85 | effect | -1.15 | -0.3010471204188482 | Destabilising | TRP | 0 | pnca_complex.pdb | ||||||||||||||||||
| 423 | L182F | L | 182 | F | A | PZA | 15.184 | -1.168 | Destabilising | -0.294 | Destabilising | -0.3018087855297157 | -0.0744680851063829 | L182 | LA182 | 4.99445 | -6.0 | -2.0 | 0.0 | 0.0 | -2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 1.0 | 0.0 | 1.0 | 1.0 | 2.0 | 0.0 | 4.0 | 0.0 | 0.18190874059397286 | Destabilising | -0.804 | Destabilising | -0.1370843989769821 | 50 | 0.2487562189054726 | E | strand | 1.5 | 4.17 | LEU | 0.281 | 0.09006410256410256 | 4 | 4 | -0.038 | 0.389 | 5:4 | 87/150 | F:Q:L:V:R:I | 47 | 0.49473684210526314 | 71 | effect | pnca_p.leu182phe | 7.18700589334483e-05 | -8.98740878149642 | 0.0001249735077034 | 0.940032862253634 | 119.468044435493 | -0.0752285585987741 | 4692673.5108132 | 2.42412778478352 | 0.384555509373631 | 0.0 | 1.0 | 0.0 | 0.0 | 188.544222231268 | 1.0341007080334399e-29 | 0.999999999999997 | -1.0 | -0.2617801047120419 | Destabilising | PHE | 0 | pnca_complex.pdb | |
| 424 | L182S | L | 182 | S | A | PZA | 15.184 | -2.349 | Destabilising | 0.38 | Stabilising | -0.6069767441860465 | 0.1704035874439461 | L182 | LA182 | 5.37676 | 22.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -1.0 | 0.0 | -1.0 | 0.0 | 4.0 | 0.0 | 4.0 | 2.0 | 0.19583330298151938 | Destabilising | -1.864 | Destabilising | -0.3178175618073316 | 50 | 0.2487562189054726 | E | strand | 1.5 | 4.17 | LEU | 0.281 | 0.09006410256410256 | 4 | 4 | -0.038 | 0.389 | 5:4 | 87/150 | F:Q:L:V:R:I | 71 | 0.7473684210526316 | 85 | effect | pnca_p.leu182ser | 0.0007187005893344 | 1.58037603086922 | 4.85678176777767 | 0.0125175169650379 | 0.632856943325042 | 2.49720896252777 | 1.34977418228528 | 17.4757677148671 | 4.85678180286436 | 0.686348592676127 | 4.85605251831648 | 0.0171758041796076 | 1.76508291991092 | 1.11658950345066 | 21.1173440246382 | 5.49640065724654 | 0.0190556572462216 | -1.98 | -0.518324607329843 | Destabilising | SER | 0 | pnca_complex.pdb |
| 425 | V183L | V | 183 | L | A | PZA | 17.921 | -0.423 | Destabilising | -0.108 | Destabilising | -0.1093023255813953 | -0.0273556231003039 | V183 | VA183 | -0.102908 | -10.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -3.0 | 0.0 | -1.0 | -2.0 | -2.0 | 0.0 | 0.0 | -4.0 | -0.01978543413058525 | Stabilising | -0.776 | Destabilising | -0.13231031543052002 | 34 | 0.1954022988505747 | E | strand | 3.5 | 4.1 | VAL | 0.4 | 0.12820512820512822 | 4 | 4 | 0.083 | 0.59 | 5:3 | 59/150 | L:V:I:R:C:T:A:G | -6 | -0.06451612903225806 | 53 | neutral | pnca_p.val183leu | 0.0001437401178668 | -9.98752126245063 | 4.59700131334244e-05 | 0.942832958100734 | 139.277183325399 | -0.0717096729269459 | 144471.706314865 | 1.2119588062211 | 0.0834878586628579 | 0.0 | 1.0 | 0.0 | 0.0 | 25.8386585962163 | 1.0105682238915901e-25 | 0.999999999999746 | -0.67 | -0.175392670157068 | Destabilising | LEU | 0 | pnca_complex.pdb |